Instruction: In the age group 80 years and older, what decreased the risk of CV events?

Output: intensive BPlowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the age group 80 years and older, what decreased the risk of CV events?. ### Response: intensive BPlowering.


Instruction: What is the risk factor for all-cause mortality?

Output: HR: 0.67

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk factor for all-cause mortality?. ### Response: HR: 0.67.


Instruction: What are the risk factors for adults with diabetes and CKD?

Output: mortality and kidney outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the risk factors for adults with diabetes and CKD?. ### Response: mortality and kidney outcomes.


Instruction: Are the benefits of intensive BPlowering more or less certain?

Output: less

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Are the benefits of intensive BPlowering more or less certain?. ### Response: less.


Instruction: What type of studies have favored more rather than less intensive BP reduction?

Output: All previous studies in diabetes with and without CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of studies have favored more rather than less intensive BP reduction?. ### Response: All previous studies in diabetes with and without CKD.


Instruction: What did Ettehad et al. report that the reduction in major CV events remained proportional to?

Output: the BP reduc-tion achieved among trial participants with diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Ettehad et al. report that the reduction in major CV events remained proportional to?. ### Response: the BP reduc-tion achieved among trial participants with diabetes.


Instruction: What proportional risk reductions were smaller than the re-ductions in those without diabetes?

Output: reductionin major CV events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What proportional risk reductions were smaller than the re-ductions in those without diabetes?. ### Response: reductionin major CV events.


Instruction: In themeta-analysis of intensive versus less-intensive BP-loweringtherapy among patients with CKD, Malhotra et al. found no evidence of heterogeneity in beneficial effects on mortality?

Output: diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In themeta-analysis of intensive versus less-intensive BP-loweringtherapy among patients with CKD, Malhotra et al. found no evidence of heterogeneity in beneficial effects on mortality?. ### Response: diabetes.


Instruction: Who conducted a systematic review and meta-analysis of RCTs that included at least 100 patients with diabetes?

Output: Brunström et al.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who conducted a systematic review and meta-analysis of RCTs that included at least 100 patients with diabetes?. ### Response: Brunström et al..


Instruction: What decreased MI, stroke,CV mortality, ESKD, and all-cause mortality if baseline SBPwas>150mm Hg?

Output: BP reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What decreased MI, stroke,CV mortality, ESKD, and all-cause mortality if baseline SBPwas>150mm Hg?. ### Response: BP reduction.


Instruction: What was decreased if baseline SBP was 140 to 150 mm Hg?

Output: MI, HF, and all-causemortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was decreased if baseline SBP was 140 to 150 mm Hg?. ### Response: MI, HF, and all-causemortality.


Instruction: What was increased when baselineSBP was 140 mmHg? What are the two major caveats regarding these meta-analyses in diabetes?

Output: these meta-analyses differ sub-stantially from each other in their respective inclusioncriteria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was increased when baselineSBP was 140 mmHg? What are the two major caveats regarding these meta-analyses in diabetes?. ### Response: these meta-analyses differ sub-stantially from each other in their respective inclusioncriteria.


Instruction: What did Brunström and Ettehad compare antihypertensives to?

Output: placebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Brunström and Ettehad compare antihypertensives to?. ### Response: placebo.


Instruction: What was the effect of 10mm Hg reduction in SBP on SBP?

Output: clinical outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the effect of 10mm Hg reduction in SBP on SBP?. ### Response: clinical outcomes.


Instruction: How many meta-analyses differ from each other?

Output: sub-stantially

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many meta-analyses differ from each other?. ### Response: sub-stantially.


Instruction: What is the effect of 10mm Hg reduction in SBP on clinical outcomes?

Output: decreases the CVevent rate and perhaps mortality and kidney outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of 10mm Hg reduction in SBP on clinical outcomes?. ### Response: decreases the CVevent rate and perhaps mortality and kidney outcomes.


Instruction: None of the trials conducted prior to ACCORD and SPRINTexamined an SBP target as low as what?

Output: <120 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: None of the trials conducted prior to ACCORD and SPRINTexamined an SBP target as low as what?. ### Response: <120 mm Hg.


Instruction: What was the prespeci fid primaryendpoint of composite CV events?

Output: all-cause death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the prespeci fid primaryendpoint of composite CV events?. ### Response: all-cause death.


Instruction: What did the ACCORD trial not show?

Output: a difference in the prespeci ﬁed primaryendpoint of composite CV events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the ACCORD trial not show?. ### Response: a difference in the prespeci ﬁed primaryendpoint of composite CV events.


Instruction: The intensive SBPtarget showed a difference in what?

Output: decreased the risk of CV events (HR: 0.66; 95% CI:0.49–0.90) and all-cause mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The intensive SBPtarget showed a difference in what?. ### Response: decreased the risk of CV events (HR: 0.66; 95% CI:0.49–0.90) and all-cause mortality.


Instruction: What did the study show?

Output: decreased the risk of CV events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the study show?. ### Response: decreased the risk of CV events.


Instruction: What was the HR of the study?

Output: 0.59

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the HR of the study?. ### Response: 0.59.


Instruction: How was the SBP lowered?

Output: intensive SBP lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the SBP lowered?. ### Response: intensive SBP lowering.


Instruction: Why did the committee decide to make a research reco mmendation to establish the added value of cardiac MRI?

Output: the clinical and cost effectiveness of adding cardiac MRI (either routinely or selectively) to echocardiography in all patients with HFREF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why did the committee decide to make a research reco mmendation to establish the added value of cardiac MRI?. ### Response: the clinical and cost effectiveness of adding cardiac MRI (either routinely or selectively) to echocardiography in all patients with HFREF.


Instruction: What was the purpose of mmendation?

Output: to establish the added value of cardiac MRI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the purpose of mmendation?. ### Response: to establish the added value of cardiac MRI.


Instruction: What did the committee discuss in the guideline scope?

Output: proposed review question

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee discuss in the guideline scope?. ### Response: proposed review question.


Instruction: What is a randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women?

Output: Evidence-based guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women?. ### Response: Evidence-based guidelines.


Instruction: What is the name of the person who was a part of the Banka CL team?

Output: Mosca L

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the person who was a part of the Banka CL team?. ### Response: Mosca L.


Instruction: What is another name for a person who is a member of the Berra K group?

Output: Benjamin EJ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for a person who is a member of the Berra K group?. ### Response: Benjamin EJ.


Instruction: Who is the other person that a group of people referred to as a banka CL?

Output: Mosca L

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the other person that a group of people referred to as a banka CL?. ### Response: Mosca L.


Instruction: Who is the Expert Panel/Writing Group?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Expert Panel/Writing Group?. ### Response: American Heart Association.


Instruction: What is the American College of Obstetricians and Gynecologists?

Output: American College of Card

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the American College of Obstetricians and Gynecologists?. ### Response: American College of Card.


Instruction: Who is the American College of Cardiology Foundation?

Output: American College of Obstetricians and Gynecologists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the American College of Cardiology Foundation?. ### Response: American College of Obstetricians and Gynecologists.


Instruction: What is the Society of Thoracic Surgeons?

Output: American College of Cardiology Foundation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Society of Thoracic Surgeons?. ### Response: American College of Cardiology Foundation.


Instruction: Where is the Office of Research on Women's Health?

Output: Centers for Disease Control and Prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the Office of Research on Women's Health?. ### Response: Centers for Disease Control and Prevention.


Instruction: What is the acronym for the American College of Nurse Practitioners?

Output: National Heart, Lung, and Blood Institute

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the American College of Nurse Practitioners?. ### Response: National Heart, Lung, and Blood Institute.


Instruction: When was the 2007 update of guidelines for cardiovascular disease pre-vention in women?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the 2007 update of guidelines for cardiovascular disease pre-vention in women?. ### Response: 2007.


Instruction: What does VA/DoD CPG f stand for?

Output: Management of Dyslipidemia for Cardiovascular Risk Reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does VA/DoD CPG f stand for?. ### Response: Management of Dyslipidemia for Cardiovascular Risk Reduction.


Instruction: When is the Provider Summary?

Output: June 2020

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is the Provider Summary?. ### Response: June 2020.


Instruction: What is a STABLE CAD?

Output: angina or equivalent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a STABLE CAD?. ### Response: angina or equivalent.


Instruction: What does PAD stand for?

Output: peripheral arterial  disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does PAD stand for?. ### Response: peripheral arterial  disease.


Instruction: What is the acronym for a bdominal aortic aneurysm?

Output: AAA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for a bdominal aortic aneurysm?. ### Response: AAA.


Instruction: What does CABG stand for?

Output: coronary artery bypass grafting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CABG stand for?. ### Response: coronary artery bypass grafting.


Instruction: What is the acronym for coronary artery bypass grafting?

Output: CABG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for coronary artery bypass grafting?. ### Response: CABG.


Instruction: What is the acronym for acute coronary syndrome?

Output: ACS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for acute coronary syndrome?. ### Response: ACS.


Instruction: What is CABG?

Output: coronary artery bypass grafting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CABG?. ### Response: coronary artery bypass grafting.


Instruction: What is the name of the drug used for coronary intervention?

Output: PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used for coronary intervention?. ### Response: PCI.


Instruction: What is a high-dose drug called?

Output: Atorvastatin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a high-dose drug called?. ### Response: Atorvastatin.


Instruction: Atorvastatin 10 – 20 mg, 40 – 80 mg, what is another high dose drug?

Output: statin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atorvastatin 10 – 20 mg, 40 – 80 mg, what is another high dose drug?. ### Response: statin.


Instruction: Rosuva statin 5 – 10 mg, 20 – 40 mg Simvastatine 20 - 40 mg, N/A Pravastatastatin 20, 40, 80 mg What is an example of a drug that can be used to treat heart disease?

Output: Atorvastatin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Rosuva statin 5 – 10 mg, 20 – 40 mg Simvastatine 20 - 40 mg, N/A Pravastatastatin 20, 40, 80 mg What is an example of a drug that can be used to treat heart disease?. ### Response: Atorvastatin.


Instruction: Pravastatin 40 – 80 mg N/A What is the name of the drug that can be used to treat cancer?

Output: Lovastatin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Pravastatin 40 – 80 mg N/A What is the name of the drug that can be used to treat cancer?. ### Response: Lovastatin.


Instruction: What is XL?

Output: sustained release

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is XL?. ### Response: sustained release.


Instruction: How much BID does Pitava statin have?

Output: twice per day

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much BID does Pitava statin have?. ### Response: twice per day.


Instruction: How long does it take to washout statin intolerant patients?

Output: 1 month

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take to washout statin intolerant patients?. ### Response: 1 month.


Instruction: What is the term for intermittent dosing?

Output: nondaily

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for intermittent dosing?. ### Response: nondaily.


Instruction: How long is the time it takes to wash out statins?

Output: 1 month

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the time it takes to wash out statins?. ### Response: 1 month.


Instruction: Intensified patient care may improve adherenc e to what medications?

Output: lipid -lowering medications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Intensified patient care may improve adherenc e to what medications?. ### Response: lipid -lowering medications.


Instruction: Statin doses listed as “moderate” are equivalent to what?

Output: moderate intensity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Statin doses listed as “moderate” are equivalent to what?. ### Response: moderate intensity.


Instruction: What are statin doses listed as high equivalent to?

Output: high intensity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are statin doses listed as high equivalent to?. ### Response: high intensity.


Instruction: What is BID: twice per day; mg: milligrams; XL: sustained release Sidebar 1: High er Risk CVD Patients  MI or ACS in past 12 months; or  Recurrent ACS, MI, or CVA?

Output: Abbreviations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is BID: twice per day; mg: milligrams; XL: sustained release Sidebar 1: High er Risk CVD Patients  MI or ACS in past 12 months; or  Recurrent ACS, MI, or CVA?. ### Response: Abbreviations.


Instruction: What type of ACS is recurrent?

Output: acute coronary syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of ACS is recurrent?. ### Response: acute coronary syndrome.


Instruction: What is a known CVD?

Output: cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a known CVD?. ### Response: cardiovascular disease.


Instruction: What may cause prothrombotic effects?

Output: aspirin and by COX-2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may cause prothrombotic effects?. ### Response: aspirin and by COX-2.


Instruction: Why should enteric-coated aspirin be avoided?

Output: its delayed and reduced absorption

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why should enteric-coated aspirin be avoided?. ### Response: its delayed and reduced absorption.


Instruction: What should be avoided initially because of its delayed and reduced absorption?

Output: Enteric-coated aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be avoided initially because of its delayed and reduced absorption?. ### Response: Enteric-coated aspirin.


Instruction: See Section 5.1.2.1 for recommendations at the time of what?

Output: PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: See Section 5.1.2.1 for recommendations at the time of what?. ### Response: PCI.


Instruction: What is the recommended maintenance dose of aspirin to be used with ticagrelor?

Output: 81 mg daily

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommended maintenance dose of aspirin to be used with ticagrelor?. ### Response: 81 mg daily.


Instruction: What is the short title of the 2017 AHA/ACC STEMI/NSTEMI Measure Set?

Output: PM-4: High-Intensity Statin at Discharge

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the short title of the 2017 AHA/ACC STEMI/NSTEMI Measure Set?. ### Response: PM-4: High-Intensity Statin at Discharge.


Instruction: What is PM-4: AMI: High-Intensity Statin Prescribed at Discharge?

Output: Percentage of patients age ≥18 y, hospitalized with AMI, who were prescribed a high-intensity statin at hospital discharge

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PM-4: AMI: High-Intensity Statin Prescribed at Discharge?. ### Response: Percentage of patients age ≥18 y, hospitalized with AMI, who were prescribed a high-intensity statin at hospital discharge.


Instruction: What type of statin is prescribed to patients with AMI at hospital discharge?

Output: high-intensity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of statin is prescribed to patients with AMI at hospital discharge?. ### Response: high-intensity.


Instruction: What is the definition of high-intensity statin dose in the 2013 ACC/AHA Guideline?

Output: Table 5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the definition of high-intensity statin dose in the 2013 ACC/AHA Guideline?. ### Response: Table 5.


Instruction: All patients with AMIDenominator Exclusions Patients age 18 yPatients who leave against medical advicePatents who die during hospitalizationPatents who are discharged to hospice or who are on comfort care measures only?

Output: Exceptions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: All patients with AMIDenominator Exclusions Patients age 18 yPatients who leave against medical advicePatents who die during hospitalizationPatents who are discharged to hospice or who are on comfort care measures only?. ### Response: Exceptions.


Instruction: Patients who are transferred to another acute care hospitalDenominator Exceptions Documentation of a medical reason for not prescribing what?

Output: high-intensity statin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients who are transferred to another acute care hospitalDenominator Exceptions Documentation of a medical reason for not prescribing what?. ### Response: high-intensity statin.


Instruction: Documentation of a medical reason for not prescribing a high-intensity statin (eg, allergy, intolerance or contraindications to high intensity statin(s)), risk of interaction between drugs, or other medical reasons)Documentation of prescription for a moderate-intent statin for patients >75 y of age?

Output: patient refusal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Documentation of a medical reason for not prescribing a high-intensity statin (eg, allergy, intolerance or contraindications to high intensity statin(s)), risk of interaction between drugs, or other medical reasons)Documentation of prescription for a moderate-intent statin for patients >75 y of age?. ### Response: patient refusal.


Instruction: What is an example of a patient reason for not prescribing a statin?

Output: patient refusal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a patient reason for not prescribing a statin?. ### Response: patient refusal.


Instruction: What is the name of the patient currently enrolled in a clinical trial related to?

Output: lipid-lowering therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the patient currently enrolled in a clinical trial related to?. ### Response: lipid-lowering therapy.


Instruction: What is the rate-limiting step in cholesterol biosynthesis?

Output: HMG-CoA reductase enzyme

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the rate-limiting step in cholesterol biosynthesis?. ### Response: HMG-CoA reductase enzyme.


Instruction: What are patients with an MI at high risk for?

Output: recurrent cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients with an MI at high risk for?. ### Response: recurrent cardiovascular events.


Instruction: Statins inhibit what enzyme?

Output: HMG-CoA reductase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Statins inhibit what enzyme?. ### Response: HMG-CoA reductase.


Instruction: What are statins shown to reduce in secondary prevention trials?

Output: cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are statins shown to reduce in secondary prevention trials?. ### Response: cardiovascular events.


Instruction: Statins have been shown to delay what type of atherosclerosis progression?

Output: coronary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Statins have been shown to delay what type of atherosclerosis progression?. ### Response: coronary.


Instruction: What could delay coronary atherosclerosis progression and possibly induce plaque regression?

Output: Statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could delay coronary atherosclerosis progression and possibly induce plaque regression?. ### Response: Statins.


Instruction: What is not supported by the clinical evidence to achieve a proposed LDL-C target?

Output: titrating statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not supported by the clinical evidence to achieve a proposed LDL-C target?. ### Response: titrating statin therapy.


Instruction: What is the paradigm of treating patients to LDL-C targets largely abandoned?

Output: Given that the clinical evidence does not support the notion of titrating statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the paradigm of treating patients to LDL-C targets largely abandoned?. ### Response: Given that the clinical evidence does not support the notion of titrating statin therapy.


Instruction: High-intensity statin therapy appears to confer incremental clinical benefit compared with what?

Output: less intensive therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: High-intensity statin therapy appears to confer incremental clinical benefit compared with what?. ### Response: less intensive therapy.


Instruction: What did the Cholesterol Treatment Trialists conduct?

Output: meta-analyses of individual participant data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Cholesterol Treatment Trialists conduct?. ### Response: meta-analyses of individual participant data.


Instruction: What did The Cholesterol Treatment Trialists conduct meta-analyses of?

Output: individual participant data from randomized trials of more versus less intensive statin regimens

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did The Cholesterol Treatment Trialists conduct meta-analyses of?. ### Response: individual participant data from randomized trials of more versus less intensive statin regimens.


Instruction: How many trials were there?

Output: 5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many trials were there?. ### Response: 5.


Instruction: What is the name of the 2018 ACHD GuidelineCirculation. 2019;139:e698–e800?

Output: Stout et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2018 ACHD GuidelineCirculation. 2019;139:e698–e800?. ### Response: Stout et al.


Instruction: What is pulmonary atresia?

Output: These conduits may be homografts or prosthetic conduits with bioprosthetic valves used within the conduit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is pulmonary atresia?. ### Response: These conduits may be homografts or prosthetic conduits with bioprosthetic valves used within the conduit.


Instruction: How many conduits may show early dysfunction?

Output: A minority

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many conduits may show early dysfunction?. ### Response: A minority.


Instruction: What causes kinking or aneurysmal di-lation?

Output: dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes kinking or aneurysmal di-lation?. ### Response: dysfunction.


Instruction: What causes the remainder of the conduit to become dysfunctional over time and require replacement or intervention?

Output: progressive stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes the remainder of the conduit to become dysfunctional over time and require replacement or intervention?. ### Response: progressive stenosis.


Instruction: How long does it take for a conduit to be dysfunctional to be replaced?

Output: 10 to 15 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take for a conduit to be dysfunctional to be replaced?. ### Response: 10 to 15 years.


Instruction: How long does it take for conduits to be placed?

Output: 10 to 15 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take for conduits to be placed?. ### Response: 10 to 15 years.


Instruction: How long can conduits last?

Output: 10 to 15 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long can conduits last?. ### Response: 10 to 15 years.


Instruction: What section of the manual provides recommendations on who should perform surgeries?

Output: Section 3.3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What section of the manual provides recommendations on who should perform surgeries?. ### Response: Section 3.3.


Instruction: What is used for routine testing and follow-up intervals?

Output: Table 28

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used for routine testing and follow-up intervals?. ### Response: Table 28.


Instruction: What type of testing involves simultaneous selective coronary angiography or aortography and balloon dilation in the RVOT?

Output: Coronary compression

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of testing involves simultaneous selective coronary angiography or aortography and balloon dilation in the RVOT?. ### Response: Coronary compression.


Instruction: What percentage of patients with right ventricle-to-PA conduits have coronary artery compression with conduit balloon angioplasty or stenting?

Output: 5% to 6%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients with right ventricle-to-PA conduits have coronary artery compression with conduit balloon angioplasty or stenting?. ### Response: 5% to 6%.


Instruction: Patients with anomalous right or left coronary heart arteries are at risk of what?

Output: coronary com-pression

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with anomalous right or left coronary heart arteries are at risk of what?. ### Response: coronary com-pression.


Instruction: What is at risk of coronary com-pression?

Output: Patients with anomalous right or left coronary arteries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is at risk of coronary com-pression?. ### Response: Patients with anomalous right or left coronary arteries.


Instruction: What is common?

Output: Right ventricle–to-PA conduit stent fracture

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is common?. ### Response: Right ventricle–to-PA conduit stent fracture.


Instruction: How many patients had right ventricle-to-PA conduit stent fracture?

Output: 26%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had right ventricle-to-PA conduit stent fracture?. ### Response: 26%.


Instruction: What does stent fracture typically present with?

Output: progressive ste-nosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does stent fracture typically present with?. ### Response: progressive ste-nosis.


Instruction: Patients with transcatheter valves may also present with worsening what?

Output: PR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with transcatheter valves may also present with worsening what?. ### Response: PR.


Instruction: What should patients with an increase in PR or PS have?

Output: fluoroscopic or x-ray assessment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients with an increase in PR or PS have?. ### Response: fluoroscopic or x-ray assessment.


Instruction: What is the annualized rate of IE in patients treated with Melody valve implantation?

Output: 2.4%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the annualized rate of IE in patients treated with Melody valve implantation?. ### Response: 2.4%.


Instruction: What type of valves are most commonly involved in in-fection?

Output: left-sided valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of valves are most commonly involved in in-fection?. ### Response: left-sided valves.


Instruction: Patients typically present with fever and malaise as well as worsening PS or PR.

Output: -sided valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients typically present with fever and malaise as well as worsening PS or PR.. ### Response: -sided valves.


Instruction: What are some symptoms of IE?

Output: fever and malaise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some symptoms of IE?. ### Response: fever and malaise.


Instruction: What can be used to treat IE if IE is identified and treatment initiated early in the disease course?

Output: intravenous antibiotics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be used to treat IE if IE is identified and treatment initiated early in the disease course?. ### Response: intravenous antibiotics.


Instruction: How is noninvasive imaging performed?

Output: echocardiog-raphy, CMR, or CTA provides a reasonably com-prehensive assessment of ventricular function, conduit function, and patency as well as pulmo-nary arterial anatomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is noninvasive imaging performed?. ### Response: echocardiog-raphy, CMR, or CTA provides a reasonably com-prehensive assessment of ventricular function, conduit function, and patency as well as pulmo-nary arterial anatomy.


Instruction: What type of imaging provides a reasonably comprehensive assessment of ventricular function, conduit function, and patency?

Output: noninvasive

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of imaging provides a reasonably comprehensive assessment of ventricular function, conduit function, and patency?. ### Response: noninvasive.


Instruction: What is reasonable to directly assess hemodynamics in the setting of clinical decompensation?

Output: cardiac catheterization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable to directly assess hemodynamics in the setting of clinical decompensation?. ### Response: cardiac catheterization.


Instruction: What is used in Work Group deliberationTopic 1: Low sodium diet or lifestyle modification and change in BPLifestyle interventions to reduce raised bloodpressure: a systematic review of randomizedcontrolled trials?

Output: Relevant systematic reviews and meta-analysesTitle ReferenceDatabases and cut-off dates ofliterature search Use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used in Work Group deliberationTopic 1: Low sodium diet or lifestyle modification and change in BPLifestyle interventions to reduce raised bloodpressure: a systematic review of randomizedcontrolled trials?. ### Response: Relevant systematic reviews and meta-analysesTitle ReferenceDatabases and cut-off dates ofliterature search Use.


Instruction: What was used to check andsupplement reference list of ERTsystematic reviewSystematic review of long term effects of adviceto reduce dietary salt in adultsHooper et al.62Cochrane CENTRALMEDLINEEmbaseCAB abstractsCVRCT registrySIGLE1982-1998Further search on sodiumrestriction and BP:

Output: References

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was used to check andsupplement reference list of ERTsystematic reviewSystematic review of long term effects of adviceto reduce dietary salt in adultsHooper et al.62Cochrane CENTRALMEDLINEEmbaseCAB abstractsCVRCT registrySIGLE1982-1998Further search on sodiumrestriction and BP:. ### Response: References.


Instruction: What does ACE-I or ARB do on CVD and CKD progressionRAS?

Output: blockade

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ACE-I or ARB do on CVD and CKD progressionRAS?. ### Response: blockade.


Instruction: What is the role of blood pressure control, proteinuria, and angiotensin-converting enzyme inhibition?

Output: chronic kidney disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of blood pressure control, proteinuria, and angiotensin-converting enzyme inhibition?. ### Response: chronic kidney disease.


Instruction: What does ACE-I or ARB blockade do?

Output: angiotensin-receptor blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ACE-I or ARB blockade do?. ### Response: angiotensin-receptor blocker.


Instruction: When did Balamuthusamy et al.97OVIDMEDLINEEmbase1975-2006References used to check andsupplement reference list of ERTsystematic review?

Output: July 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Balamuthusamy et al.97OVIDMEDLINEEmbase1975-2006References used to check andsupplement reference list of ERTsystematic review?. ### Response: July 2002.


Instruction: What is an anti-hypertensive treatment for patients with diabetes mellitus?

Output: Angiotensin receptor blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an anti-hypertensive treatment for patients with diabetes mellitus?. ### Response: Angiotensin receptor blockers.


Instruction: What is the name of the meta-analysis of controlled double-blindrandomized trials?

Output: Siebenhofer et al.450

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis of controlled double-blindrandomized trials?. ### Response: Siebenhofer et al.450.


Instruction: What are the references used to check andsupplement reference list of ERTsystematic reviewTopic 4: ACE-I or ARB on CKD progression?

Output: 1992–2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the references used to check andsupplement reference list of ERTsystematic reviewTopic 4: ACE-I or ARB on CKD progression?. ### Response: 1992–2002.


Instruction: What is ACE-I on CKD without DMAngiotensin-converting enzyme inhibitors andprogression of non-diabetic renal disease?

Output: CKD progression

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ACE-I on CKD without DMAngiotensin-converting enzyme inhibitors andprogression of non-diabetic renal disease?. ### Response: CKD progression.


Instruction: What is the name of the meta-analysis of patient-level data?

Output: Jafar et al.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis of patient-level data?. ### Response: Jafar et al..


Instruction: What is ACE-I angiotensin-converting enzyme inhibitor?

Output: ARB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ACE-I angiotensin-converting enzyme inhibitor?. ### Response: ARB.


Instruction: What is ARB?

Output: angiotensin-receptor blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ARB?. ### Response: angiotensin-receptor blocker.


Instruction: What is ACE-I?

Output: angiotensin-converting enzyme inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ACE-I?. ### Response: angiotensin-converting enzyme inhibitor.


Instruction: What is one of the largest RASi studies?

Output: The HOPE study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the largest RASi studies?. ### Response: The HOPE study.


Instruction: What did the HOPE study report in people at high CVrisk with or without high BP?

Output: CV bene ﬁts with an ACEi versus placebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the HOPE study report in people at high CVrisk with or without high BP?. ### Response: CV bene ﬁts with an ACEi versus placebo.


Instruction: How many patients with no or mildly increased albuminuria were in the prespeci fied CKD sub-group?

Output: 3394

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with no or mildly increased albuminuria were in the prespeci fied CKD sub-group?. ### Response: 3394.


Instruction: How much did ACEire reduce the risk for all-cause mortality?

Output: 20%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much did ACEire reduce the risk for all-cause mortality?. ### Response: 20%.


Instruction: What was the mean follow-up of patients with no or mildly increased albuminuria?

Output: 4.5 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean follow-up of patients with no or mildly increased albuminuria?. ### Response: 4.5 years.


Instruction: How long did the HOPEstudy last?

Output: 4.5 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the HOPEstudy last?. ### Response: 4.5 years.


Instruction: How many patients had diabetes in the overall study?

Output: 3577

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had diabetes in the overall study?. ### Response: 3577.


Instruction: What percentage of the patients with diabetes did not have albuminuria?

Output: 2437

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the patients with diabetes did not have albuminuria?. ### Response: 2437.


Instruction: What should beadministered using the highest approved dose that istolerated to achieve the bene fits described?

Output: RASi

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should beadministered using the highest approved dose that istolerated to achieve the bene fits described?. ### Response: RASi.


Instruction: The Work Group judged that a large majority of physicians would be comfortable initiating what?

Output: RAS blockade treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The Work Group judged that a large majority of physicians would be comfortable initiating what?. ### Response: RAS blockade treatment.


Instruction: What does RAS blockade do?

Output: in-hibits the action of aldosterone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does RAS blockade do?. ### Response: in-hibits the action of aldosterone.


Instruction: What is the benefit of RASi given in less than recommended doses?

Output: less certain

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the benefit of RASi given in less than recommended doses?. ### Response: less certain.


Instruction: Who is familiar with the drug?

Output: physicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is familiar with the drug?. ### Response: physicians.


Instruction: What are less certain in less thanmaximally recommended doses?

Output: bene ﬁts from RASi

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are less certain in less thanmaximally recommended doses?. ### Response: bene ﬁts from RASi.


Instruction: What may still be reasonable if the patient cannot tolerate the maximum dose?

Output: a smaller dose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may still be reasonable if the patient cannot tolerate the maximum dose?. ### Response: a smaller dose.


Instruction: The maximum dose of RASi allowed by theregulatory agency varies by what country?

Output: country

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The maximum dose of RASi allowed by theregulatory agency varies by what country?. ### Response: country.


Instruction: What are two potent antihypertensive drugs?

Output: ACEi and ARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are two potent antihypertensive drugs?. ### Response: ACEi and ARBs.


Instruction: When should changes in BP, serum creatinine, andserum potassium be checked?

Output: within 2 –4 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When should changes in BP, serum creatinine, andserum potassium be checked?. ### Response: within 2 –4 weeks.


Instruction: What are potent antihypertensive agents that counteract the vasoconstrictive effects of angiotensin II?

Output: ACEi and ARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are potent antihypertensive agents that counteract the vasoconstrictive effects of angiotensin II?. ### Response: ACEi and ARBs.


Instruction: What causes selec-tively greater vas-odilatation of the efferent arterioles of theglomeruli?

Output: blocking the action of angiotensin II

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes selec-tively greater vas-odilatation of the efferent arterioles of theglomeruli?. ### Response: blocking the action of angiotensin II.


Instruction: What causes a decrease in the GFR and a rise in the serum creatinine?

Output: blocking the action of angiotensin II

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes a decrease in the GFR and a rise in the serum creatinine?. ### Response: blocking the action of angiotensin II.


Instruction: What blockade inhibits the action of aldosterone?

Output: RAS blockade

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What blockade inhibits the action of aldosterone?. ### Response: RAS blockade.


Instruction: What is recommended before and at 1 – 2 weeks after initiation of RASi?

Output: measuring serum potassium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended before and at 1 – 2 weeks after initiation of RASi?. ### Response: measuring serum potassium.


Instruction: What will typically occur during the first 2 weeks of treatment initiation?

Output: An increase in serum creatinine level

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will typically occur during the first 2 weeks of treatment initiation?. ### Response: An increase in serum creatinine level.


Instruction: How long should patients be monitored for symptomatic hypotension, hyperkalemia, andserum creatinine after initiating or changing the dose of the drug?

Output: 2 –4 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long should patients be monitored for symptomatic hypotension, hyperkalemia, andserum creatinine after initiating or changing the dose of the drug?. ### Response: 2 –4 weeks.


Instruction: What type of abnor -malities occur in patients with hypertension?

Output: structural

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of abnor -malities occur in patients with hypertension?. ### Response: structural.


Instruction: What stage of hypertension is LV hypertrophy or MI?

Output: stage B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What stage of hypertension is LV hypertrophy or MI?. ### Response: stage B.


Instruction: On what date will ahajournals.org be available?

Output: May 3, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On what date will ahajournals.org be available?. ### Response: May 3, 2023.


Instruction: What are the nonpathogenic bacteria that are representative of hun-dreds of strains of aerobic and anaerobic species?

Output: 1491

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the nonpathogenic bacteria that are representative of hun-dreds of strains of aerobic and anaerobic species?. ### Response: 1491.


Instruction: What is a term for -hemolytic streptococci?

Output: VGS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a term for -hemolytic streptococci?. ### Response: VGS.


Instruction: Prevotella and Actinomyces spe-cies are examples of what?

Output: oral flora

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Prevotella and Actinomyces spe-cies are examples of what?. ### Response: oral flora.


Instruction: In health, the child's oral flora has a variety of which species?

Output: VGS, Neisseria species, Haemophilus species, and Staphylococcus species

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In health, the child's oral flora has a variety of which species?. ### Response: VGS, Neisseria species, Haemophilus species, and Staphylococcus species.


Instruction: What is the name of a species responsible for periodontal diseases in older children?

Output: Capnocytophaga

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of a species responsible for periodontal diseases in older children?. ### Response: Capnocytophaga.


Instruction: What type of plaque biofilm formation begins on the teeth of children at risk for IE?

Output: supragingival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of plaque biofilm formation begins on the teeth of children at risk for IE?. ### Response: supragingival.


Instruction: When does dental plaque biofilm formation begin?

Output: soon after a tooth surface is cleaned

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When does dental plaque biofilm formation begin?. ### Response: soon after a tooth surface is cleaned.


Instruction: In adults, plaque bacteria is what type of flora?

Output: bacte-rial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In adults, plaque bacteria is what type of flora?. ### Response: bacte-rial.


Instruction: What are the visible surfaces of the teeth called?

Output: supragingival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the visible surfaces of the teeth called?. ### Response: supragingival.


Instruction: What is the name of the crevice where there are more Gram-negative and anaerobic bacteria?

Output: gingival crevice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the crevice where there are more Gram-negative and anaerobic bacteria?. ### Response: gingival crevice.


Instruction: What is the host response to plaque called?

Output: gingival inflammation and enlargement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the host response to plaque called?. ### Response: gingival inflammation and enlargement.


Instruction: What can result in an increased depth to the shallow gingival crevice between the tooth surface and the mucosa?

Output: Gingivitis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can result in an increased depth to the shallow gingival crevice between the tooth surface and the mucosa?. ### Response: Gingivitis.


Instruction: What is difficult to clean with a toothbrush and floss?

Output: gingival crevicular mucosa

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is difficult to clean with a toothbrush and floss?. ### Response: gingival crevicular mucosa.


Instruction: What serves as a barrier to bacterial invasion?

Output: cre-vicular mucosa

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What serves as a barrier to bacterial invasion?. ### Response: cre-vicular mucosa.


Instruction: Where is the source of most transient bacteremia that occur from the mouth?

Output: the child’s gingival crevice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the source of most transient bacteremia that occur from the mouth?. ### Response: the child’s gingival crevice.


Instruction: What can lead to thinning and ulceration?

Output: Gingival inflam-mation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can lead to thinning and ulceration?. ### Response: Gingival inflam-mation.


Instruction: What may result from office-based dental procedures or routine activities of daily living?

Output: bacteremia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may result from office-based dental procedures or routine activities of daily living?. ### Response: bacteremia.


Instruction: What may result from minimal gingival manipulation?

Output: Bacteremia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may result from minimal gingival manipulation?. ### Response: Bacteremia.


Instruction: Children have a much lower prevalence and severity of what?

Output: gingivitis and periodon-titis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Children have a much lower prevalence and severity of what?. ### Response: gingivitis and periodon-titis.


Instruction: What is a frequent source of bacteremia?

Output: Dental procedures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a frequent source of bacteremia?. ### Response: Dental procedures.


Instruction: What are dental procedures a par ticular source of?

Output: bacteremia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are dental procedures a par ticular source of?. ### Response: bacteremia.


Instruction: How many clinical studies of chil-dren have focused on the impact of 1 of the following risks?

Output: Multiple

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many clinical studies of chil-dren have focused on the impact of 1 of the following risks?. ### Response: Multiple.


Instruction: Nature and invasiveness of dental procedures42,44,47,49,53

Output: acteremia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Nature and invasiveness of dental procedures42,44,47,49,53. ### Response: acteremia.


Instruction: What is a prophylactic antibiotic?

Output: drug

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a prophylactic antibiotic?. ### Response: drug.


Instruction: What is the nature and invasiveness of dental procedures42,44,47,49,53?

Output: indices of oral hygiene and dis-ease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the nature and invasiveness of dental procedures42,44,47,49,53?. ### Response: indices of oral hygiene and dis-ease.


Instruction: Indicators of oral hygiene and what else?

Output: dis-ease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Indicators of oral hygiene and what else?. ### Response: dis-ease.


Instruction: What is part 9 of the 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care?

Output: post-cardiac arrest care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is part 9 of the 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care?. ### Response: post-cardiac arrest care.


Instruction: What is the name of the seventh report of the Joint National Committee on Prevention, Detection, and Treatment of Cardiovascular Disease?

Output: JNC 7 report

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the seventh report of the Joint National Committee on Prevention, Detection, and Treatment of Cardiovascular Disease?. ### Response: JNC 7 report.


Instruction: What was the 7th report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure called?

Output: the JNC 7 report

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 7th report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure called?. ### Response: the JNC 7 report.


Instruction: When did the JNC 7 report come out?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the JNC 7 report come out?. ### Response: 2003.


Instruction: What is the name of the report?

Output: American College of Cardiology Foundation/American Heart Association Task Force on Clinical Data Standards

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the report?. ### Response: American College of Cardiology Foundation/American Heart Association Task Force on Clinical Data Standards.


Instruction: What is the name of the Task Force on Clinical Data Standards?

Output: American College of Cardiology Foundation/American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Clinical Data Standards?. ### Response: American College of Cardiology Foundation/American Heart Association.


Instruction: What is a report of the American College of Cardiology Foundation/American Heart Association?

Output: Task Force on Clinical Data Standards

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a report of the American College of Cardiology Foundation/American Heart Association?. ### Response: Task Force on Clinical Data Standards.


Instruction: What is the acronym for Syndromes and Coronary Artery Disease Clinical Data Standards?

Output: Acute Coronary Syndromes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Syndromes and Coronary Artery Disease Clinical Data Standards?. ### Response: Acute Coronary Syndromes.


Instruction: Circulation. 2013;127:1052–89.

Output: 34

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation. 2013;127:1052–89.. ### Response: 34.


Instruction: What was the name of the Task Force on Clinical Expert Consensus Documents in 2012?

Output: American College of Cardiology Foundation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the Task Force on Clinical Expert Consensus Documents in 2012?. ### Response: American College of Cardiology Foundation.


Instruction: What is the name of the Task Force on Clinical Expert Consensus Documents?

Output: American College of Cardiology Foundation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Clinical Expert Consensus Documents?. ### Response: American College of Cardiology Foundation.


Instruction: When was the J Am Coll Cardiol 60:2427-63?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol 60:2427-63?. ### Response: 2012.


Instruction: What is a scientific statement from the American Heart Association?

Output: Testing of low-risk patients presenting to the emergency department with chest pain

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a scientific statement from the American Heart Association?. ### Response: Testing of low-risk patients presenting to the emergency department with chest pain.


Instruction: What is the name of the scientific statement from the American Heart Association and the American Diabetes Association?

Output: mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the scientific statement from the American Heart Association and the American Diabetes Association?. ### Response: mellitus.


Instruction: When did Diabetes Care. 2007:30:162–72?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Diabetes Care. 2007:30:162–72?. ### Response: 2007.


Instruction: Who is Harper SA, Fukuda K, Uyeki TM, et al?

Output: 37

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Harper SA, Fukuda K, Uyeki TM, et al?. ### Response: 37.


Instruction: What is the acronym for the Advisory Committee on Immunization Practices?

Output: ACIP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the Advisory Committee on Immunization Practices?. ### Response: ACIP.


Instruction: When was MMWR Recomm Rep.54:1–40?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was MMWR Recomm Rep.54:1–40?. ### Response: 2005.


Instruction: What are the current concepts of the pathogenesis of the acute coronary syn-dromes called?

Output: Libby P

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the current concepts of the pathogenesis of the acute coronary syn-dromes called?. ### Response: Libby P.


Instruction: What type of angina is it time for a requiem?

Output: Unstable

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of angina is it time for a requiem?. ### Response: Unstable.


Instruction: What is the name of the journal that studies the association between hospital process performance and outcomes among acute coronary syndrome patients?

Output: JAMA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies the association between hospital process performance and outcomes among acute coronary syndrome patients?. ### Response: JAMA.


Instruction: What is the TIMI risk score for chest pain?

Output: low

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the TIMI risk score for chest pain?. ### Response: low.


Instruction: Who is the author of Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine?

Output: Benow RO, Braunwalk E

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine?. ### Response: Benow RO, Braunwalk E.


Instruction: What is the TIMI risk score for unstable angina/non-ST elevation MI?

Output: 42

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the TIMI risk score for unstable angina/non-ST elevation MI?. ### Response: 42.


Instruction: What is a method for prognostication and therapeutic decision making?

Output: The TIMI risk score for unstable angina/non-ST elevation MI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a method for prognostication and therapeutic decision making?. ### Response: The TIMI risk score for unstable angina/non-ST elevation MI.


Instruction: When was the JAMA 284:835-42 published?

Output: 2000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the JAMA 284:835-42 published?. ### Response: 2000.


Instruction: How many patients were enrolled in an international trial of ST-segment elevation?

Output: 9461

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were enrolled in an international trial of ST-segment elevation?. ### Response: 9461.


Instruction: What is the short-term risk of macrovas-cular events in type 2 diabetes mellitus?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the short-term risk of macrovas-cular events in type 2 diabetes mellitus?. ### Response: stroke.


Instruction: What has been rec-ommended by the American Diabetes Association to prevent long-term microangiopathic complications?

Output: A glycated hemoglobin goal of <7.0%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been rec-ommended by the American Diabetes Association to prevent long-term microangiopathic complications?. ### Response: A glycated hemoglobin goal of <7.0%.


Instruction: How much has been glycated hemoglobin goal?

Output: <7.0%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much has been glycated hemoglobin goal?. ### Response: <7.0%.


Instruction: What does the American Diabetes Association want to prevent in patients with type 2 diabetes mellitus?

Output: long-term microangiopathic complications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the American Diabetes Association want to prevent in patients with type 2 diabetes mellitus?. ### Response: long-term microangiopathic complications.


Instruction: What is another question that needs further study?

Output: Whether control to this level also reduces the long-term risk of stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another question that needs further study?. ### Response: Whether control to this level also reduces the long-term risk of stroke.


Instruction: In patients with recent-onset type I diabetes, how can intensive diabetes therapy be achieved?

Output: with good adherence but with more fre-quent episodes of severe hypoglycemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with recent-onset type I diabetes, how can intensive diabetes therapy be achieved?. ### Response: with good adherence but with more fre-quent episodes of severe hypoglycemia.


Instruction: What can be achieved with good adherence but with more frequent episodes of severe hypoglycemia?

Output: intensive diabetes therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be achieved with good adherence but with more frequent episodes of severe hypoglycemia?. ### Response: intensive diabetes therapy.


Instruction: What was similar between the groups over a mean 17 years of follow-up in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions?

Output: glyce-mia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was similar between the groups over a mean 17 years of follow-up in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions?. ### Response: glyce-mia.


Instruction: How much did intensive treatment reduce the risk of any CVD event?

Output: 42%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much did intensive treatment reduce the risk of any CVD event?. ### Response: 42%.


Instruction: What was the com-bined risk nonfatal MI, stroke, or death from CVD events by?

Output: 57%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the com-bined risk nonfatal MI, stroke, or death from CVD events by?. ### Response: 57%.


Instruction: The decrease in glycated hemoglobin was associated with what?

Output: the positive effects of inten-sive treatment on the overall risk of CVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The decrease in glycated hemoglobin was associated with what?. ### Response: the positive effects of inten-sive treatment on the overall risk of CVD.


Instruction: What was associated with the positive effects of inten-sive treatment on the overall risk of CVD?

Output: The decrease in glycated hemoglobin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with the positive effects of inten-sive treatment on the overall risk of CVD?. ### Response: The decrease in glycated hemoglobin.


Instruction: What was too few strokes to evaluate the effect of improved glycemia during the trial?

Output: There were too few strokes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was too few strokes to evaluate the effect of improved glycemia during the trial?. ### Response: There were too few strokes.


Instruction: What type of diabetes mellitus has no evidence that tight glycemic control reduces risk of stroke?

Output: type 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diabetes mellitus has no evidence that tight glycemic control reduces risk of stroke?. ### Response: type 2.


Instruction: What is the lack of convincing support from any individual clinical trial?

Output: intensified glycemic control to reduce stroke incidence in patients with diabetes mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the lack of convincing support from any individual clinical trial?. ### Response: intensified glycemic control to reduce stroke incidence in patients with diabetes mellitus.


Instruction: A recent meta-analysis provided some supportive evidence in a subgroup of what?

Output: patients with diabetes mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A recent meta-analysis provided some supportive evidence in a subgroup of what?. ### Response: patients with diabetes mellitus.


Instruction: What did a recent meta-analysis provide in a subgroup of patients with diabetes mellitus?

Output: supportive evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a recent meta-analysis provide in a subgroup of patients with diabetes mellitus?. ### Response: supportive evidence.


Instruction: How many studies were identified from 649 identified studies?

Output: 9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were identified from 649 identified studies?. ### Response: 9.


Instruction: The authors identified how many relevant trials?

Output: 9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The authors identified how many relevant trials?. ### Response: 9.


Instruction: Intensive control of glucose compared with usual care had no effect on what?

Output: incident stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Intensive control of glucose compared with usual care had no effect on what?. ### Response: incident stroke.


Instruction: What did glucose compared with usual care have no effect on?

Output: incident stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did glucose compared with usual care have no effect on?. ### Response: incident stroke.


Instruction: What was a beneficial effect seen in patients with diabetes mellitus and a BMI >30 kg/m2?

Output: in a stratified analyses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a beneficial effect seen in patients with diabetes mellitus and a BMI >30 kg/m2?. ### Response: in a stratified analyses.


Instruction: Diabetes Mellitus and Hypertension More aggressive lowering of what?

Output: BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Diabetes Mellitus and Hypertension More aggressive lowering of what?. ### Response: BP.


Instruction: What does more aggressive lowering of BP in diabetes mellitus and hypertension reduce?

Output: stroke incidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does more aggressive lowering of BP in diabetes mellitus and hypertension reduce?. ### Response: stroke incidence.


Instruction: What reduces stroke incidence in patients with diabetes mellitus?

Output: More aggressive lowering of BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What reduces stroke incidence in patients with diabetes mellitus?. ### Response: More aggressive lowering of BP.


Instruction: The UKPDS found that tight BP control reduces what?

Output: the risk of stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The UKPDS found that tight BP control reduces what?. ### Response: the risk of stroke.


Instruction: What did the UKPDS find about diabetes mellitus?

Output: tight BP control (mean BP, 144/82 mm Hg) resulted in a 44% reduction (95% CI, 11–65; P=0.013) in the risk of stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the UKPDS find about diabetes mellitus?. ### Response: tight BP control (mean BP, 144/82 mm Hg) resulted in a 44% reduction (95% CI, 11–65; P=0.013) in the risk of stroke.


Instruction: What did tight BP control result in?

Output: 44% reduction (95% CI, 11–65; P=0.013) in the risk of stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did tight BP control result in?. ### Response: 44% reduction (95% CI, 11–65; P=0.013) in the risk of stroke.


Instruction: How much reduction in the risk of stroke was there compared to more liberal control?

Output: 44%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much reduction in the risk of stroke was there compared to more liberal control?. ### Response: 44%.


Instruction: What was the nonsta-tistically significant 22% risk reduction with antihypertensive treatment in subjects with dia-betes mellitus in SHEP?

Output: 301

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the nonsta-tistically significant 22% risk reduction with antihypertensive treatment in subjects with dia-betes mellitus in SHEP?. ### Response: 301.


Instruction: How many patients with type 1 diabetes had type 2 diabetes in the UKPDS?

Output: 884

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with type 1 diabetes had type 2 diabetes in the UKPDS?. ### Response: 884.


Instruction: What is the North-American perspective on undergoing coronary stenting?

Output: Thromb Haemost. 2011;106(4):572-584

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the North-American perspective on undergoing coronary stenting?. ### Response: Thromb Haemost. 2011;106(4):572-584.


Instruction: When did Thromb Haemost publish it's 106(4):572-584?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Thromb Haemost publish it's 106(4):572-584?. ### Response: 2011.


Instruction: What is the name of the oral antiplatelet therapy used in patients undergoing coronary stenting?

Output: oral anticoagulant therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the oral antiplatelet therapy used in patients undergoing coronary stenting?. ### Response: oral anticoagulant therapy.


Instruction: What year did Am J Cardiol publish 102 ( 12): 1618 - 1623?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Am J Cardiol publish 102 ( 12): 1618 - 1623?. ### Response: 2008.


Instruction: Aspirin and clopid-ogrel with or without phenprocoumon after drug eluting coronary stent placement in patients on chronic oral antico-agulation?

Output: Warfarin plus aspirin after myocardial infarction or the acute coronary syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Aspirin and clopid-ogrel with or without phenprocoumon after drug eluting coronary stent placement in patients on chronic oral antico-agulation?. ### Response: Warfarin plus aspirin after myocardial infarction or the acute coronary syndrome.


Instruction: On chronic oral antico-agulation?

Output: Aspirin and clopid-ogrel with or without phenprocoumon after drug eluting coronary stent placement in patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On chronic oral antico-agulation?. ### Response: Aspirin and clopid-ogrel with or without phenprocoumon after drug eluting coronary stent placement in patients.


Instruction: What journal published 264 ( 5 ): 472 - 480 in 2008?

Output: J Intern Med

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What journal published 264 ( 5 ): 472 - 480 in 2008?. ### Response: J Intern Med.


Instruction: What is the name of the study that examined therapeutic strat-egies after coronary stenting in chronically anticoagulated patients?

Output: MUSICA study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined therapeutic strat-egies after coronary stenting in chronically anticoagulated patients?. ### Response: MUSICA study.


Instruction: 1488. 120. Gao F, Zhou YJ, Wang ZJ, et al. Comparison of different antithrombotic regimens for patients with atrial fi brilla-tion undergoing drug-eluting stent implantation?

Output: 1488

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: 1488. 120. Gao F, Zhou YJ, Wang ZJ, et al. Comparison of different antithrombotic regimens for patients with atrial fi brilla-tion undergoing drug-eluting stent implantation?. ### Response: 1488.


Instruction: Atrial fibrillation undergoing drug-eluting stent implantation?

Output: atrial ﬁ  brilla-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atrial fibrillation undergoing drug-eluting stent implantation?. ### Response: atrial ﬁ  brilla-tion.


Instruction: Circ J. 2010; 74 ( 4 ): 701-708.

Output: Comparison of different antithrombotic regimens for patients with atrial ﬁ  brilla-tion undergoing drug-eluting stent implantation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circ J. 2010; 74 ( 4 ): 701-708.. ### Response: Comparison of different antithrombotic regimens for patients with atrial ﬁ  brilla-tion undergoing drug-eluting stent implantation.


Instruction: Rothberg MB, Celestin C, Fiore.

Output: LD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Rothberg MB, Celestin C, Fiore.. ### Response: LD.


Instruction: What is the name of the meta-analysis with estimates of risk and benefi t?

Output: Ann Intern Med

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis with estimates of risk and benefi t?. ### Response: Ann Intern Med.


Instruction: What is Warfarin plus aspirin after myocardial infarction?

Output: acute coronary syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Warfarin plus aspirin after myocardial infarction?. ### Response: acute coronary syndrome.


Instruction: What is the 9th ed of the American College of Chest Physicians evidence-based clinical prac-tice guidelines?

Output: therapy and prevention of thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 9th ed of the American College of Chest Physicians evidence-based clinical prac-tice guidelines?. ### Response: therapy and prevention of thrombosis.


Instruction: What does Chest 141(2)(suppl):e152S-e184S do?

Output: 92

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Chest 141(2)(suppl):e152S-e184S do?. ### Response: 92.


Instruction: What is the effect of patient self-testing and self-management of long-term anticoagulation on major clinical outcomes?

Output: Meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of patient self-testing and self-management of long-term anticoagulation on major clinical outcomes?. ### Response: Meta-analysis.


Instruction: Patient self-testing and self-management of long-term anticoagulation on major clinical outcomes?

Output: Meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patient self-testing and self-management of long-term anticoagulation on major clinical outcomes?. ### Response: Meta-analysis.


Instruction: How many ( 7 ): 472-482?

Output: 154

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many ( 7 ): 472-482?. ### Response: 154.


Instruction: What is dabigatran compared to warfarin for?

Output: stroke preven-tion in atrial ﬁ  brillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is dabigatran compared to warfarin for?. ### Response: stroke preven-tion in atrial ﬁ  brillation.


Instruction: What is the difference in cost-effectiveness in atrial fibrillation?

Output: Cost-effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference in cost-effectiveness in atrial fibrillation?. ### Response: Cost-effectiveness.


Instruction: What is the NICE national clinical guideline for management of atrial fi brillation called?

Output: Guideline Development Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the NICE national clinical guideline for management of atrial fi brillation called?. ### Response: Guideline Development Group.


Instruction: How many ( 1 ): 1-11?

Output: 154

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many ( 1 ): 1-11?. ### Response: 154.


Instruction: What is the national clinical guideline for management of atrial fi brillation in primary and secondary care?

Output: NICE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the national clinical guideline for management of atrial fi brillation in primary and secondary care?. ### Response: NICE.


Instruction: What is a systematic review of risk fac-tors for anticoagulation-related bleeding complications in patients?

Output: MUSICA study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a systematic review of risk fac-tors for anticoagulation-related bleeding complications in patients?. ### Response: MUSICA study.


Instruction: When did QJM issue its 100 (10): 599 - 607?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did QJM issue its 100 (10): 599 - 607?. ### Response: 2007.


Instruction: What is the average age of a person in 2007?

Output: 119

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the average age of a person in 2007?. ### Response: 119.


Instruction: How many people in 2007 lived in poverty?

Output: 599 - 607

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people in 2007 lived in poverty?. ### Response: 599 - 607.


Instruction: What is a risk factor for major bleeding?

Output: Prospective evalua-tion of an index for predicting the risk of major bleeding in outpatients treated with warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for major bleeding?. ### Response: Prospective evalua-tion of an index for predicting the risk of major bleeding in outpatients treated with warfarin.


Instruction: What is an index for predicting the risk of major bleeding in outpatients treated with warfarin?

Output: Prospective evalua-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an index for predicting the risk of major bleeding in outpatients treated with warfarin?. ### Response: Prospective evalua-tion.


Instruction: What is the incidence of major bleeding in outpatients treated with warfarin?

Output: risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the incidence of major bleeding in outpatients treated with warfarin?. ### Response: risk.


Instruction: What is known at the start of outpatient therapy?

Output: Major bleeding in outpatients treated with warfarin: incidence and prediction by fac-tors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is known at the start of outpatient therapy?. ### Response: Major bleeding in outpatients treated with warfarin: incidence and prediction by fac-tors.


Instruction: How many ( 2 ): 144?

Output: 87

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many ( 2 ): 144?. ### Response: 87.


Instruction: 87 ( 2 ): 144 - 152?

Output: Am J Med

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: 87 ( 2 ): 144 - 152?. ### Response: Am J Med.


Instruction: What was the average age of the respondents in 1989?

Output: 144 - 152

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the average age of the respondents in 1989?. ### Response: 144 - 152.


Instruction: Who developed a contemporary bleeding risk model for elderly warfarin recipients?

Output: Ellerbeck

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who developed a contemporary bleeding risk model for elderly warfarin recipients?. ### Response: Ellerbeck.


Instruction: Atrial pacing is more commonly used in situations where atrial wires are already in place, such as in the postoperative setting or in patients with programmable cardiac implanted electrical devices?

Output: 364

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atrial pacing is more commonly used in situations where atrial wires are already in place, such as in the postoperative setting or in patients with programmable cardiac implanted electrical devices?. ### Response: 364.