Instruction: When did Du ZM, Feinberg MS, and Shechter M publish their findings?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Du ZM, Feinberg MS, and Shechter M publish their findings?. ### Response: 2006.


Instruction: What is an improvement in endothelial function in patients with refractoryangina pectoris?

Output: External counterpulsationtherapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an improvement in endothelial function in patients with refractoryangina pectoris?. ### Response: External counterpulsationtherapy.


Instruction: What is the diagnostic value of advanced imaging mo-dalities for the detection of mitral annuloplasty ring and prosthetic valve dehiscence?

Output: 7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the diagnostic value of advanced imaging mo-dalities for the detection of mitral annuloplasty ring and prosthetic valve dehiscence?. ### Response: 7.


Instruction: What is real-time 3-dimensional trans-esophageal echocardiography for?

Output: evaluation of post-operative mitral annuloplasty ring and prosthetic valve dehiscence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is real-time 3-dimensional trans-esophageal echocardiography for?. ### Response: evaluation of post-operative mitral annuloplasty ring and prosthetic valve dehiscence.


Instruction: What is the diagnostic value of advanced imaging mo-dalities for the detection and differentiation of prosthetic valve obstruction?

Output: 8. Kim JY, Suh YJ, Han K, et al. Diagnostic value of advanced imaging mo-dalities for the detection and differentiation of prosthetic valve obstruc-tion: a systematic review and meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the diagnostic value of advanced imaging mo-dalities for the detection and differentiation of prosthetic valve obstruction?. ### Response: 8. Kim JY, Suh YJ, Han K, et al. Diagnostic value of advanced imaging mo-dalities for the detection and differentiation of prosthetic valve obstruc-tion: a systematic review and meta-analysis.


Instruction: When did JACC Cardiovasc Imaging issue 12:2182-92?

Output: 2019

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did JACC Cardiovasc Imaging issue 12:2182-92?. ### Response: 2019.


Instruction: What was the name of the systematic review and meta-analysis?

Output: Diagnostic value of advanced imaging mo-dalities for the detection and differentiation of prosthetic valve obstruc-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the systematic review and meta-analysis?. ### Response: Diagnostic value of advanced imaging mo-dalities for the detection and differentiation of prosthetic valve obstruc-tion.


Instruction: How was hemodynamic valve deterioration determined after bioprosthetic surgical aortic valve replacement?

Output: Rate, timing, correlates, and out-comes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was hemodynamic valve deterioration determined after bioprosthetic surgical aortic valve replacement?. ### Response: Rate, timing, correlates, and out-comes.


Instruction: What causes hemodynamic valve deterioration after bioprosthetic surgical aortic valve replacement?

Output: struc-tural valve degeneration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes hemodynamic valve deterioration after bioprosthetic surgical aortic valve replacement?. ### Response: struc-tural valve degeneration.


Instruction: What is Rahimtoola SH's job title?

Output: 10. Rahimtoola SH. Choice of prosthetic heart valve in adults an update

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Rahimtoola SH's job title?. ### Response: 10. Rahimtoola SH. Choice of prosthetic heart valve in adults an update.


Instruction: What is weighed against reoperation risk after aortic valve replacement?

Output: lifetime anticoagulant-related event risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is weighed against reoperation risk after aortic valve replacement?. ### Response: lifetime anticoagulant-related event risk.


Instruction: What is the risk of lifetime anticoagulant-related event?

Output: reopera-tion risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of lifetime anticoagulant-related event?. ### Response: reopera-tion risk.


Instruction: When was the J Thorac Cardiovasc Surg. 137:881–6, 866.e1–5?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Thorac Cardiovasc Surg. 137:881–6, 866.e1–5?. ### Response: 2009.


Instruction: What is the standard definition of struc-tural valve degeneration for surgical and transcatheter bioprosthetic aortic valves?

Output: Standardized

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the standard definition of struc-tural valve degeneration for surgical and transcatheter bioprosthetic aortic valves?. ### Response: Standardized.


Instruction: What does Douglas PS, Leon MB, Mack MJ, et al. study?

Output: Longitudinal hemodynamics of transcatheter and surgical aortic valves in the PARTNER trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Douglas PS, Leon MB, Mack MJ, et al. study?. ### Response: Longitudinal hemodynamics of transcatheter and surgical aortic valves in the PARTNER trial.


Instruction: How long did the PARTNER trial last?

Output: 5-Year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the PARTNER trial last?. ### Response: 5-Year.


Instruction: What is the name of the study that evaluated long-term outcomes of transcatheter and surgical aortic valve replacement?

Output: PARTNER trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated long-term outcomes of transcatheter and surgical aortic valve replacement?. ### Response: PARTNER trial.


Instruction: What is the name of the randomised controlled trial for high surgical risk patients with aortic stenosis?

Output: PARTNER 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised controlled trial for high surgical risk patients with aortic stenosis?. ### Response: PARTNER 1.


Instruction: How long does it take to replace a transcatheter valve?

Output: 5-Year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take to replace a transcatheter valve?. ### Response: 5-Year.


Instruction: What is PARTNER 1?

Output: a randomised controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PARTNER 1?. ### Response: a randomised controlled trial.


Instruction: What is stenosis?

Output: aortic stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is stenosis?. ### Response: aortic stenosis.


Instruction: What is the name of the randomised controlled trial?

Output: PARTNER 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised controlled trial?. ### Response: PARTNER 1.


Instruction: When did the Lancet issue 385:2485-91?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Lancet issue 385:2485-91?. ### Response: 2015.


Instruction: Who is the author of the study?

Output: Manoharan G

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of the study?. ### Response: Manoharan G.


Instruction: What is the name of the study that evaluated 1-Year outcomes with the Evolut R self-expanding transcatheter aortic valve?

Output: inter -national FORWARD study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated 1-Year outcomes with the Evolut R self-expanding transcatheter aortic valve?. ### Response: inter -national FORWARD study.


Instruction: When was the JACC Cardiovasc Interv. 2018 11:2326–34?

Output: April 27, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the JACC Cardiovasc Interv. 2018 11:2326–34?. ### Response: April 27, 2023.


Instruction: What is one of the recommendations for drug-interaction management?

Output: recommen-dation 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the recommendations for drug-interaction management?. ### Response: recommen-dation 2.


Instruction: What is another recommendation for point-of-care international normalized ratio testing?

Output: 3 and 4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another recommendation for point-of-care international normalized ratio testing?. ### Response: 3 and 4.


Instruction: What are AMSs?

Output: specialized anticoagulation-managementservices

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are AMSs?. ### Response: specialized anticoagulation-managementservices.


Instruction: What are efforts to improve adherence to?

Output: anticoagulant-medication regimens

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are efforts to improve adherence to?. ### Response: anticoagulant-medication regimens.


Instruction: What are good practice statements?

Output: renal function monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are good practice statements?. ### Response: renal function monitoring.


Instruction: Who developed the guidelines for renal function monitoring?

Output: McMaster University GRADE Centre

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who developed the guidelines for renal function monitoring?. ### Response: McMaster University GRADE Centre.


Instruction: What was recommended by the Institute of Medicine?

Output: guideline development

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was recommended by the Institute of Medicine?. ### Response: guideline development.


Instruction: What approach was used to assess evidence and formulate recommendations?

Output: Grading of Recommendations Assessment,Development and Evaluation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What approach was used to assess evidence and formulate recommendations?. ### Response: Grading of Recommendations Assessment,Development and Evaluation.


Instruction: What is the strength of a recommendation expressed as?

Output: strong

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the strength of a recommendation expressed as?. ### Response: strong.


Instruction: What does guidelinepanel suggest?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does guidelinepanel suggest?. ### Response: ….


Instruction: What is not likely to be needed to help individual patients make decisions?

Output: Formal decision aids

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not likely to be needed to help individual patients make decisions?. ### Response: Formal decision aids.


Instruction: What is not likely to be neededto help individual patients make decisions consistent with their values and preferences?

Output: Formal decision aids

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not likely to be neededto help individual patients make decisions consistent with their values and preferences?. ### Response: Formal decision aids.


Instruction: What can be adopted as policy in most situations?

Output: The recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be adopted as policy in most situations?. ### Response: The recommendation.


Instruction: Adherence to the recommendation can be used as what?

Output: quality criterion orperformance indicator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Adherence to the recommendation can be used as what?. ### Response: quality criterion orperformance indicator.


Instruction: What is the term for a recommendation that is supported by credible research or other convincing judgments that make additional research unlikely to alter it?

Output: researchers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for a recommendation that is supported by credible research or other convincing judgments that make additional research unlikely to alter it?. ### Response: researchers.


Instruction: What may provide important information that alters the recommendations?

Output: further research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may provide important information that alters the recommendations?. ### Response: further research.


Instruction: What may be useful in helping patients to make decisions consistent with their individual risks, values, and preferences?

Output: Decision aids

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be useful in helping patients to make decisions consistent with their individual risks, values, and preferences?. ### Response: Decision aids.


Instruction: What do clinicians need to help each patient arrive at?

Output: commended course of action

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do clinicians need to help each patient arrive at?. ### Response: commended course of action.


Instruction: Who published the 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease?

Output: Arnett et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease?. ### Response: Arnett et al.


Instruction: What should clinicians and individuals focus attention on living a healthy lifestyle?

Output: evi-dence-based recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should clinicians and individuals focus attention on living a healthy lifestyle?. ### Response: evi-dence-based recommendations.


Instruction: What are these recommendations to help prevent?

Output: ASCVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are these recommendations to help prevent?. ### Response: ASCVD.


Instruction: What is the aim of this guideline?

Output: patient-centered approaches

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the aim of this guideline?. ### Response: patient-centered approaches.


Instruction: How does the ACC and AHA try to de-sign?

Output: a comprehensive yet succinct compilation of practi-cal guidance for the primary prevention of ASCVD and to promote optimal dissemination of information by us-ing concise language and formatting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does the ACC and AHA try to de-sign?. ### Response: a comprehensive yet succinct compilation of practi-cal guidance for the primary prevention of ASCVD and to promote optimal dissemination of information by us-ing concise language and formatting.


Instruction: How do we promote optimal dissemination of information?

Output: concise language and formatting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do we promote optimal dissemination of information?. ### Response: concise language and formatting.


Instruction: What are the recommen-dations listed in this guideline evidence based and supported by?

Output: an extensive evidence review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the recommen-dations listed in this guideline evidence based and supported by?. ### Response: an extensive evidence review.


Instruction: A search for literature derived from research involving human sub-jects published in English?

Output: Methodology and Evidence Review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A search for literature derived from research involving human sub-jects published in English?. ### Response: Methodology and Evidence Review.


Instruction: What is another name for National Institute for Health and Care Excellence?

Output: NICE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for National Institute for Health and Care Excellence?. ### Response: NICE.


Instruction: When was this study conducted?

Output: May and July 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this study conducted?. ### Response: May and July 2018.


Instruction: What are RCTs?

Output: Randomized controlled trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are RCTs?. ### Response: Randomized controlled trials.


Instruction: What are meta-analyses and large, United States-based, high-quality cohort studies evaluated for?

Output: their content on the preven-tion of ASCVD outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are meta-analyses and large, United States-based, high-quality cohort studies evaluated for?. ### Response: their content on the preven-tion of ASCVD outcomes.


Instruction: How many topic areas are related to ASCVD outcomes?

Output: 9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many topic areas are related to ASCVD outcomes?. ### Response: 9.


Instruction: What is type 2 diabetes mellitus?

Output: T2DM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is type 2 diabetes mellitus?. ### Response: T2DM.


Instruction: Blood cholesterol, hypertension, smoking cessation, and aspirin use are topics related to what?

Output: risk assessment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Blood cholesterol, hypertension, smoking cessation, and aspirin use are topics related to what?. ### Response: risk assessment.


Instruction: What is the USPSTF?

Output: US Preventive Services Task Force

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the USPSTF?. ### Response: US Preventive Services Task Force.


Instruction: What summarizes the evidence used to formulate recommendations?

Output: The final evidence tables included in the Online Data Supplement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What summarizes the evidence used to formulate recommendations?. ### Response: The final evidence tables included in the Online Data Supplement.


Instruction: Who is a healthcare advisory services firm?

Output: Avalere Health

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a healthcare advisory services firm?. ### Response: Avalere Health.


Instruction: Who served as the document manager for this guideline?

Output: Avalere Health

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who served as the document manager for this guideline?. ### Response: Avalere Health.


Instruction: What did Avalere Health facilitate the deliberations of the Writing Committee?

Output: document manager

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Avalere Health facilitate the deliberations of the Writing Committee?. ### Response: document manager.


Instruction: Who did the modified Delphi process for establishing the Class of Recommendation?

Output: Avalere Health

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who did the modified Delphi process for establishing the Class of Recommendation?. ### Response: Avalere Health.


Instruction: Who conducted a systematic evidence review for the key topic of exercise and physical activity?

Output: Lee Ann Prebil

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who conducted a systematic evidence review for the key topic of exercise and physical activity?. ### Response: Lee Ann Prebil.


Instruction: Who conducted targeted literature searches to support the document’s discussion of exercise?

Output: Lee Ann Prebil

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who conducted targeted literature searches to support the document’s discussion of exercise?. ### Response: Lee Ann Prebil.


Instruction: What did Lee Ann Prebil conduct in parallel?

Output: a systematic evidence review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Lee Ann Prebil conduct in parallel?. ### Response: a systematic evidence review.


Instruction: What type of care does this document focus on?

Output: living a healthy lifestyle

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of care does this document focus on?. ### Response: living a healthy lifestyle.


Instruction: What kind of care is the focus of this document?

Output: team-based care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What kind of care is the focus of this document?. ### Response: team-based care.


Instruction: In addition to team-based care, shared decision-making, and assessment of social determinants, what type of approach is discussed?

Output: patient-centered

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In addition to team-based care, shared decision-making, and assessment of social determinants, what type of approach is discussed?. ### Response: patient-centered.


Instruction: What is the name of the 2019 AHA/ACC High Blood Pressure Performance and Quality MeasuresCirc Cardiovasc Qual Outcomes. 2019;12:e000057?

Output: Casey et al;

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2019 AHA/ACC High Blood Pressure Performance and Quality MeasuresCirc Cardiovasc Qual Outcomes. 2019;12:e000057?. ### Response: Casey et al;.


Instruction: What does QM-1 stand for?

Output: Nonpharmacological Interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does QM-1 stand for?. ### Response: Nonpharmacological Interventions.


Instruction: What is the percentage of patients with ACC/AHA stage elevated BP who have a documented discussion of Intensive Lifestyle Modification in 1 visits During the Measurement Year?

Output: Percentage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the percentage of patients with ACC/AHA stage elevated BP who have a documented discussion of Intensive Lifestyle Modification in 1 visits During the Measurement Year?. ### Response: Percentage.


Instruction: How many visits during the measurement year are there for documented discussion of intensive lifestyle modification?

Output: ≥1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many visits during the measurement year are there for documented discussion of intensive lifestyle modification?. ### Response: ≥1.


Instruction: What is the name of the group of patients who have a documented discussion about intensive lifestyle change at least once in the performance year?

Output: Numerator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group of patients who have a documented discussion about intensive lifestyle change at least once in the performance year?. ### Response: Numerator.


Instruction: Whose guidelines on nonpharmacological therapy do patients follow?

Output: ACC/AHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Whose guidelines on nonpharmacological therapy do patients follow?. ### Response: ACC/AHA.


Instruction: Who had at least 1 outpatient encounter with a diagnosis of HBP during the first 6 mo of the measurement year or any time before the measurement period?

Output: All patients 18–85 y of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who had at least 1 outpatient encounter with a diagnosis of HBP during the first 6 mo of the measurement year or any time before the measurement period?. ### Response: All patients 18–85 y of age.


Instruction: Pregnancy, BP readings taken during an inpatient stayDenominator Exceptions NoneWhat is the number of patients 18-85 y of age with BP diagnosis?

Output: All patients 18–85 y of age who had at least 1 outpatient encounter with a diagnosis of HBP during the first 6 mo of the measurement year or any time before the measurement periodDenominator Exclusions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Pregnancy, BP readings taken during an inpatient stayDenominator Exceptions NoneWhat is the number of patients 18-85 y of age with BP diagnosis?. ### Response: All patients 18–85 y of age who had at least 1 outpatient encounter with a diagnosis of HBP during the first 6 mo of the measurement year or any time before the measurement periodDenominator Exclusions.


Instruction: What is the name of the medical record/prospective data collection flow sheet?

Output: Data Paper

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the medical record/prospective data collection flow sheet?. ### Response: Data Paper.


Instruction: What is another name for expanded administrative data?

Output: multiple source

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for expanded administrative data?. ### Response: multiple source.


Instruction: What type of organization is responsible for the management of elevated BP?

Output: accountable care organization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of organization is responsible for the management of elevated BP?. ### Response: accountable care organization.


Instruction: What is the name of the type of care setting?

Output: Outpatient

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the type of care setting?. ### Response: Outpatient.


Instruction: Which type of therapy is useful in preventing stage 1 or 2 hypertension?

Output: pharmacological

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which type of therapy is useful in preventing stage 1 or 2 hypertension?. ### Response: pharmacological.


Instruction: What is a fundamental approach to the prevention and management of elevated BP?

Output: Dietary modification

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a fundamental approach to the prevention and management of elevated BP?. ### Response: Dietary modification.


Instruction: What complements pharmacological management of hypertension?

Output: Dietary modification

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What complements pharmacological management of hypertension?. ### Response: Dietary modification.


Instruction: The DASH diet is high in what?

Output: fruits, vegetables, potassium, calcium, magnesium, and fiber

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The DASH diet is high in what?. ### Response: fruits, vegetables, potassium, calcium, magnesium, and fiber.


Instruction: What has been shown to be effective in lowering BP?

Output: The DASH diet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been shown to be effective in lowering BP?. ### Response: The DASH diet.


Instruction: What diet produces, on average, overall reductions in SBP among those diagnosed with hypertension?

Output: DASH diet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What diet produces, on average, overall reductions in SBP among those diagnosed with hypertension?. ### Response: DASH diet.


Instruction: What type of diet contributes to the disproportionate burden of hypertension among blacks?

Output: US Southern-style diet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diet contributes to the disproportionate burden of hypertension among blacks?. ### Response: US Southern-style diet.


Instruction: Low-carbohydrate, high-protein, and vegetarian dietary patterns have been shown to lower what?

Output: BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Low-carbohydrate, high-protein, and vegetarian dietary patterns have been shown to lower what?. ### Response: BP.


Instruction: What has been shown to lower BP?

Output: The DASH diet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been shown to lower BP?. ### Response: The DASH diet.


Instruction: What is a strong and dose-dependent association between?

Output: excessive alcohol consumption

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a strong and dose-dependent association between?. ### Response: excessive alcohol consumption.


Instruction: How many standard drinks per day are consumed?

Output: (>3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many standard drinks per day are consumed?. ### Response: (>3.


Instruction: What year was the Centers for Disease Control and Prevention founded?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the Centers for Disease Control and Prevention founded?. ### Response: 2015.


Instruction: What is the association of statin adherence with mortality in patients with atherosclerotic cardiovascular disease?

Output: 125

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association of statin adherence with mortality in patients with atherosclerotic cardiovascular disease?. ### Response: 125.


Instruction: What is the PMID for Mann DM, Woodward M, Muntner P, Falzon L, Kronish I. Predictors of nonadherence to statins: A systematic review and meta-analysis. Ann Pharmacother. Sep 2010;44( 9):1410 -1421. What is Pittman DG, Chen W, Bowlin SJ, Foody JM?

Output: 20702755

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the PMID for Mann DM, Woodward M, Muntner P, Falzon L, Kronish I. Predictors of nonadherence to statins: A systematic review and meta-analysis. Ann Pharmacother. Sep 2010;44( 9):1410 -1421. What is Pittman DG, Chen W, Bowlin SJ, Foody JM?. ### Response: 20702755.


Instruction: What are statins associated with?

Output: mortality in patients with atherosclerotic cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are statins associated with?. ### Response: mortality in patients with atherosclerotic cardiovascular disease.


Instruction: What is the name of the 2011 issue of Am J Cardiol?

Output: Jun 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2011 issue of Am J Cardiol?. ### Response: Jun 1.


Instruction: Who is the author of this article?

Output: Pittman DG, Chen W, Bowlin SJ, Foody JM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of this article?. ### Response: Pittman DG, Chen W, Bowlin SJ, Foody JM.


Instruction: What type of diet is recommended for primary and secondary prevention of cardiovascular disease?

Output: Mediterranean -style

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diet is recommended for primary and secondary prevention of cardiovascular disease?. ### Response: Mediterranean -style.


Instruction: When did Cochrane Database Syst Rev. Jun 10 2015(6):CD011737.

Output: Reduction in saturated fat intake

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Cochrane Database Syst Rev. Jun 10 2015(6):CD011737.. ### Response: Reduction in saturated fat intake.


Instruction: What did Rees K, Takeda A, Martin N, et al. recommend for the prevention of?

Output: Mediterranean -style diet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Rees K, Takeda A, Martin N, et al. recommend for the prevention of?. ### Response: Mediterranean -style diet.


Instruction: What is a guideline you can trust?

Output: Pharmacologic Treatment of Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a guideline you can trust?. ### Response: Pharmacologic Treatment of Hypertension.


Instruction: What is the name of the volume 95, Number 9 of American Family Physician?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the volume 95, Number 9 of American Family Physician?. ### Response: www.aafp.org/afp.


Instruction: Where is Paul A. James, MD from?

Output: Seattle, Washington

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Paul A. James, MD from?. ### Response: Seattle, Washington.


Instruction: What type of medications treat asymptomatic individuals at risk of a disease?

Output: Preventive

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of medications treat asymptomatic individuals at risk of a disease?. ### Response: Preventive.


Instruction: What must be met when guidelines recommend lifelong preventive medications?

Output: A high standard

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must be met when guidelines recommend lifelong preventive medications?. ### Response: A high standard.


Instruction: What should be informed by good evidence that the benefits outweigh the harms?

Output: Preventive medications treat asymptomatic individuals at risk of a disease, rather than those diagnosed with a disease. A high standard must be met when guidelines recommend lifelong preventive medications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be informed by good evidence that the benefits outweigh the harms?. ### Response: Preventive medications treat asymptomatic individuals at risk of a disease, rather than those diagnosed with a disease. A high standard must be met when guidelines recommend lifelong preventive medications.


Instruction: Clinical guidelines that inform those decisions should be rigorously what?

Output: developed, evidence based, and trustworthy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Clinical guidelines that inform those decisions should be rigorously what?. ### Response: developed, evidence based, and trustworthy.


Instruction: What should clinical guidelines that inform decisions be?

Output: rigorously developed, evidence based, and trustworthy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should clinical guidelines that inform decisions be?. ### Response: rigorously developed, evidence based, and trustworthy.


Instruction: What should guidelines for the management of hypertension be evaluated in?

Output: clinical guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should guidelines for the management of hypertension be evaluated in?. ### Response: clinical guidelines.


Instruction: Who collaborated on a clinical guideline for hypertension?

Output: The American Academy of Family Physicians (AAFP) and the American College of Physicians (ACP)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who collaborated on a clinical guideline for hypertension?. ### Response: The American Academy of Family Physicians (AAFP) and the American College of Physicians (ACP).


Instruction: Who collaborated on a clinical guideline for the treatment of hypertension in adults 60 years and older?

Output: The American Academy of Family Physicians (AAFP) and the American College of Physicians (ACP)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who collaborated on a clinical guideline for the treatment of hypertension in adults 60 years and older?. ### Response: The American Academy of Family Physicians (AAFP) and the American College of Physicians (ACP).


Instruction: What does ACP stand for?

Output: American College of Physicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ACP stand for?. ### Response: American College of Physicians.


Instruction: In what issue of American Family Physician are the recommendations summarized?

Output: Volume 95

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what issue of American Family Physician are the recommendations summarized?. ### Response: Volume 95.


Instruction: What was the name of the report that the AAFP/ACP guideline effort adhered to?

Output: Clinical Practice Guidelines We Can Trust

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the report that the AAFP/ACP guideline effort adhered to?. ### Response: Clinical Practice Guidelines We Can Trust.


Instruction: What did IOM refer to as a standard for clinical practice guidelines?

Output: We Can Trust

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did IOM refer to as a standard for clinical practice guidelines?. ### Response: We Can Trust.


Instruction: Whose standards were set by the IOM?

Output: Institute of Medicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Whose standards were set by the IOM?. ### Response: Institute of Medicine.


Instruction: What methodol -ogy was used to evaluate evidence and rate recommendations?

Output: GRADE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What methodol -ogy was used to evaluate evidence and rate recommendations?. ### Response: GRADE.


Instruction: General internal medicine and family medicine were represented on what panel?

Output: ACP Clinical Guidelines Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: General internal medicine and family medicine were represented on what panel?. ### Response: ACP Clinical Guidelines Committee.


Instruction: What is considered out of date after five years or if replaced earlier?

Output: ACP Clinical Guidelines Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is considered out of date after five years or if replaced earlier?. ### Response: ACP Clinical Guidelines Committee.


Instruction: What was external review provided through?

Output: the AAFP and ACP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was external review provided through?. ### Response: the AAFP and ACP.


Instruction: What should be commended for following the IOM standards?

Output: the guideline panel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be commended for following the IOM standards?. ### Response: the guideline panel.


Instruction: Who convened the guideline panel?

Output: National Heart, Lung, and Blood Institute

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who convened the guideline panel?. ### Response: National Heart, Lung, and Blood Institute.


Instruction: When was the Eighth Joint National Committee convened?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Eighth Joint National Committee convened?. ### Response: 2008.


Instruction: What was the target systolic blood pressure of adults 60 years and older?

Output: 150 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the target systolic blood pressure of adults 60 years and older?. ### Response: 150 mm Hg.


Instruction: What was the recommended systolic blood pressure of 150 mm Hg?

Output: BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the recommended systolic blood pressure of 150 mm Hg?. ### Response: BP.


Instruction: What did some in the hypertension and cardiovascular communities push back against?

Output: systolic blood pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did some in the hypertension and cardiovascular communities push back against?. ### Response: systolic blood pressure.


Instruction: SPRINT was a large randomized controlled trial since what publication?

Output: JNC 8 guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: SPRINT was a large randomized controlled trial since what publication?. ### Response: JNC 8 guideline.


Instruction: What did Rosendorff et al Treatment of Hypertension in Patients With CAD 1385improve compared with usual con-trol?

Output: cardiovascular outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Rosendorff et al Treatment of Hypertension in Patients With CAD 1385improve compared with usual con-trol?. ### Response: cardiovascular outcomes.


Instruction: What was the risk of all-cause mortality in an extended follow-up of 9 years?

Output: 22.8% versus 21.8%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk of all-cause mortality in an extended follow-up of 9 years?. ### Response: 22.8% versus 21.8%,.


Instruction: What was the mean BP achieved in the intensive group in the ABCD trial?

Output: 132/78 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean BP achieved in the intensive group in the ABCD trial?. ### Response: 132/78 mm Hg.


Instruction: What is uncertain about the small difference?

Output: whether this can be regarded as a contribution to clinical decision making

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is uncertain about the small difference?. ### Response: whether this can be regarded as a contribution to clinical decision making.


Instruction: What was the difference between intensive and moderate BP con-trol groups after 5 years?

Output: there was no difference

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the difference between intensive and moderate BP con-trol groups after 5 years?. ### Response: there was no difference.


Instruction: What did INVEST not show?

Output: the ABCD participants in the intensive group had a significant reduction in all-cause mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did INVEST not show?. ### Response: the ABCD participants in the intensive group had a significant reduction in all-cause mortality.


Instruction: How long did it take for the intensive group to see a difference in BP?

Output: 5 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for the intensive group to see a difference in BP?. ### Response: 5 years.


Instruction: What type of mortality did ABCD participants in the intensive group have a significant reduction in?

Output: all-cause

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of mortality did ABCD participants in the intensive group have a significant reduction in?. ### Response: all-cause.


Instruction: What is the goal BP for diabetes mellitus of the American Diabetes Association?

Output: <140/80 mm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the goal BP for diabetes mellitus of the American Diabetes Association?. ### Response: <140/80 mm.


Instruction: What should be included among those deemed to be appropriate for atherosclerotic stroke patients?

Output: Lower BP Goals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be included among those deemed to be appropriate for atherosclerotic stroke patients?. ### Response: Lower BP Goals.


Instruction: What is the goal BP of 140/80 mm Hg?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the goal BP of 140/80 mm Hg?. ### Response: <.


Instruction: What should be included among those deemed to be at high risk of?

Output: Lower BP Goals for the Prevention of Stroke Patients with atherosclerotic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be included among those deemed to be at high risk of?. ### Response: Lower BP Goals for the Prevention of Stroke Patients with atherosclerotic stroke.


Instruction: How much is the risk of atherosclerotic stroke over 10 years?

Output: ≥20%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much is the risk of atherosclerotic stroke over 10 years?. ### Response: ≥20%.


Instruction: What was the effect of intensive BP lowering on ACCORD?

Output: there was no excess MI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the effect of intensive BP lowering on ACCORD?. ### Response: there was no excess MI.


Instruction: What have other studies documented on stroke outcomes?

Output: the effects of BP lower -ing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have other studies documented on stroke outcomes?. ### Response: the effects of BP lower -ing.


Instruction: With how many excep-tion are reports consistent with supporting better stroke outcomes with BPs 130/80 mm Hg?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: With how many excep-tion are reports consistent with supporting better stroke outcomes with BPs 130/80 mm Hg?. ### Response: 1.


Instruction: What is the exception to the exception?

Output: a post hoc observational analysis of the Prevention Regimen for Effectively Avoiding Second Strokes (PROFESS) data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the exception to the exception?. ### Response: a post hoc observational analysis of the Prevention Regimen for Effectively Avoiding Second Strokes (PROFESS) data.


Instruction: How many patients had a recent ischemic stroke?

Output: 20 330

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had a recent ischemic stroke?. ### Response: 20 330.


Instruction: What was not an inclusion criterion for PROFESS?

Output: Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not an inclusion criterion for PROFESS?. ### Response: Hypertension.


Instruction: What is the primary focus of the study?

Output: cardiovascular

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary focus of the study?. ### Response: cardiovascular.


Instruction: What was the adjusted hazard ratio for subjects with an SBP in the 120- to 129-mm Hg range during the 2.5 years of follow-up?

Output: 1.10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the adjusted hazard ratio for subjects with an SBP in the 120- to 129-mm Hg range during the 2.5 years of follow-up?. ### Response: 1.10.


Instruction: What was the confidence interval for stroke in the 139-mm Hg range?

Output: 1.10 (95% confidence interval, 0.95–1.28

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the confidence interval for stroke in the 139-mm Hg range?. ### Response: 1.10 (95% confidence interval, 0.95–1.28.


Instruction: What percentage confidence interval was 1.01 for fatal stroke?

Output: 95%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage confidence interval was 1.01 for fatal stroke?. ### Response: 95%.


Instruction: How many randomized trials were included in the meta-analysis?

Output: 147

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many randomized trials were included in the meta-analysis?. ### Response: 147.


Instruction: How many randomized trials of antihypertensive therapy were included in the meta-analysis?

Output: 147

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many randomized trials of antihypertensive therapy were included in the meta-analysis?. ### Response: 147.


Instruction: What were the reductions in coro-nary heart disease events and stroke similar in people with and without CVD and regardless of BP before treatment?

Output: percentage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the reductions in coro-nary heart disease events and stroke similar in people with and without CVD and regardless of BP before treatment?. ### Response: percentage.


Instruction: How many intervention trials of BP were included in a meta-regression analysis?

Output: 31

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many intervention trials of BP were included in a meta-regression analysis?. ### Response: 31.


Instruction: What does QM-2 Inpatient Early Invasive Strategy (within 24 Hours) in High-Risk NSTEMI Patients seek to implement in the 2014 AHA/ACC NSTE-ACS guideline11?

Output: a Class I (Level of Evidence A) recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does QM-2 Inpatient Early Invasive Strategy (within 24 Hours) in High-Risk NSTEMI Patients seek to implement in the 2014 AHA/ACC NSTE-ACS guideline11?. ### Response: a Class I (Level of Evidence A) recommendation.


Instruction: What did the writing committee feel it was necessary to implement?

Output: therapeutic hypothermia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the writing committee feel it was necessary to implement?. ### Response: therapeutic hypothermia.


Instruction: What did the writing committee feel was best to keep as a quality measure for many reasons?

Output: QM-2 Inpatient Early Invasive Strategy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the writing committee feel was best to keep as a quality measure for many reasons?. ### Response: QM-2 Inpatient Early Invasive Strategy.


Instruction: What does early invasive strategy reduce more than delayed invasive strategies?

Output: recurrent ischemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does early invasive strategy reduce more than delayed invasive strategies?. ### Response: recurrent ischemia.


Instruction: What does this strategy reduce rather than the hard outcomes of recurrent MI or death?

Output: length of stay and costs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does this strategy reduce rather than the hard outcomes of recurrent MI or death?. ### Response: length of stay and costs.


Instruction: What is a logistical burden on cardiac catheterization labs?

Output: this strategy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a logistical burden on cardiac catheterization labs?. ### Response: this strategy.


Instruction: Why is objective risk stratification by risk scores usually not available in current registries?

Output: ascertaining which patients benefit from early invasive strategy may not be readily feasible

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is objective risk stratification by risk scores usually not available in current registries?. ### Response: ascertaining which patients benefit from early invasive strategy may not be readily feasible.


Instruction: What is usually not available in current registries?

Output: objective risk stratification by risk scores

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is usually not available in current registries?. ### Response: objective risk stratification by risk scores.


Instruction: Ascertaining which patients benefit from early invasive strategy may not be readily feasible what?

Output: objective risk stratification by risk scores is usually not available in current registries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Ascertaining which patients benefit from early invasive strategy may not be readily feasible what?. ### Response: objective risk stratification by risk scores is usually not available in current registries.


Instruction: What measure seeks to implement a Class I recommendation in the 2013 ACCF/AHA?

Output: QM-3 Inpatient Therapeutic Hypothermia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What measure seeks to implement a Class I recommendation in the 2013 ACCF/AHA?. ### Response: QM-3 Inpatient Therapeutic Hypothermia.


Instruction: What was the recommendation in the 2013 ACCF/AHA STEMI guideline12?

Output: therapeutic hypothermia should be started as soon as possible

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the recommendation in the 2013 ACCF/AHA STEMI guideline12?. ### Response: therapeutic hypothermia should be started as soon as possible.


Instruction: What should be started as soon as possible in comatose patients with STEMI and out-of-hospital cardiac arrest caused by VF or VT?

Output: therapeutic hypothermia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be started as soon as possible in comatose patients with STEMI and out-of-hospital cardiac arrest caused by VF or VT?. ### Response: therapeutic hypothermia.


Instruction: What was best to keep this as a quality measure because of newer controversial data pertinent to the effectiveness, timing, and implementation of therapeutic hypothermia?

Output: The writing committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was best to keep this as a quality measure because of newer controversial data pertinent to the effectiveness, timing, and implementation of therapeutic hypothermia?. ### Response: The writing committee.


Instruction: What do pr ofessionals and practitioners expect to tak when e xercising t heir judgement?

Output: this guideline fully int o account

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do pr ofessionals and practitioners expect to tak when e xercising t heir judgement?. ### Response: this guideline fully int o account.


Instruction: What are the r ecommendations in NICE?

Output: epresent t he view of NICE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the r ecommendations in NICE?. ### Response: epresent t he view of NICE.


Instruction: What are practitioners expected to tak e this guideline fully int o account?

Output: assess and r educe t he en vironmental impact

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are practitioners expected to tak e this guideline fully int o account?. ### Response: assess and r educe t he en vironmental impact.


Instruction: What is not mandatory to apply t he recommendations?

Output: It is not mandat ory

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not mandatory to apply t he recommendations?. ### Response: It is not mandat ory.


Instruction: What does not verride t he responsibility to make decisions appr opriat e to the cir cumstances of a person?

Output: t he guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not verride t he responsibility to make decisions appr opriat e to the cir cumstances of a person?. ### Response: t he guideline.


Instruction: What should all pr oblems related to a medicine or medical de vice be r eported to?

Output: Medicines and Healt hcare product s Regulat ory Agency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should all pr oblems related to a medicine or medical de vice be r eported to?. ### Response: Medicines and Healt hcare product s Regulat ory Agency.


Instruction: What does the Medicines and Healt hcare product s Regulat ory Agency use?

Output: Yellow Car

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Medicines and Healt hcare product s Regulat ory Agency use?. ### Response: Yellow Car.


Instruction: Who has a responsibility to enable t he guideline to be applied when individual pr ofessionals and people using sertaint h care use a guideline?

Output: Local commissioners and pr oviders of healt hcare

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who has a responsibility to enable t he guideline to be applied when individual pr ofessionals and people using sertaint h care use a guideline?. ### Response: Local commissioners and pr oviders of healt hcare.


Instruction: What should be applied when individual pr ofessionals and people using ser vices wish to use it?

Output: guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be applied when individual pr ofessionals and people using ser vices wish to use it?. ### Response: guideline.


Instruction: What should the y do in t he cont ext of local and national priorities?

Output: funding and developing ser vices

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should the y do in t he cont ext of local and national priorities?. ### Response: funding and developing ser vices.


Instruction: What should not be int erpreted in a wa y?

Output: guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not be int erpreted in a wa y?. ### Response: guideline.


Instruction: What should be eliminated in light of t heir duties?

Output: unlawful discrimination

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be eliminated in light of t heir duties?. ### Response: unlawful discrimination.


Instruction: Who has a responsibility to promote an environmentally sustainable healt h and car e syst em?

Output: Commissioners and pr oviders

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who has a responsibility to promote an environmentally sustainable healt h and car e syst em?. ### Response: Commissioners and pr oviders.


Instruction: What should be int erpreted in a wa y that would be inconsist ent wit h his duties?

Output: Not hing in t his guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be int erpreted in a wa y that would be inconsist ent wit h his duties?. ### Response: Not hing in t his guideline.


Instruction: What should assess and r educe the environmental impact of implementing NICE recommendations wher ever possible?

Output: Commissioners and pr oviders

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should assess and r educe the environmental impact of implementing NICE recommendations wher ever possible?. ### Response: Commissioners and pr oviders.


Instruction: Cardiovascular disease: risk assessment and reduction, including lipid modification(CG181)?

Output: NICE 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cardiovascular disease: risk assessment and reduction, including lipid modification(CG181)?. ### Response: NICE 2023.


Instruction: What is the subject t o Notice of right s?

Output: All right s reserved

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the subject t o Notice of right s?. ### Response: All right s reserved.


Instruction: Where is the last updat ed?

Output: 10 F ebruar y 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the last updat ed?. ### Response: 10 F ebruar y 2023.


Instruction: How many federally funded trials were included in the evidence review?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many federally funded trials were included in the evidence review?. ### Response: 3.


Instruction: What did the VA Cooperative Trial, HDFP, andSHEP demonstrate?

Output: treatment ofhypertensionwithantihypertensivemedicationsreducescardio-vascular or cerebrovascular events and/or mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the VA Cooperative Trial, HDFP, andSHEP demonstrate?. ### Response: treatment ofhypertensionwithantihypertensivemedicationsreducescardio-vascular or cerebrovascular events and/or mortality.


Instruction: How did the trials all use thiazide-type diuretics compared with placebo?

Output: Thesetrials all used thiazide-type diuretics compared with placebo orusual care as the basis of therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did the trials all use thiazide-type diuretics compared with placebo?. ### Response: Thesetrials all used thiazide-type diuretics compared with placebo orusual care as the basis of therapy.


Instruction: What reduces risk from BPlowering?

Output: trials of β-blocker vsplacebo16,27andCCBvsplacebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What reduces risk from BPlowering?. ### Response: trials of β-blocker vsplacebo16,27andCCBvsplacebo.


Instruction: What was more effective than aCCB orACEI?

Output: thiazide-type di-uretic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was more effective than aCCB orACEI?. ### Response: thiazide-type di-uretic.


Instruction: Why were -blockers not recommended as first line therapy?

Output: be-causeinonestudyinitialtreatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why were -blockers not recommended as first line therapy?. ### Response: be-causeinonestudyinitialtreatment.


Instruction: What is not satisf actorily contr olled wit h two anti-anginal drugs?

Output: the person's sympt oms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not satisf actorily contr olled wit h two anti-anginal drugs?. ### Response: the person's sympt oms.


Instruction: The person is waiting for f or revascularisation or r evascularisation is not considered appr opriat e or acceptable?

Output: PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The person is waiting for f or revascularisation or r evascularisation is not considered appr opriat e or acceptable?. ### Response: PCI.


Instruction: What is a comorbidity, contraindications, t he person's pr eference and drug cost based on?

Output: Decide which drug t o use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a comorbidity, contraindications, t he person's pr eference and drug cost based on?. ### Response: Decide which drug t o use.


Instruction: What are people wi th stab le ang ina w hose sym ptoms ar e not sa tisfactoril y controlled wi the optimal me dical treatmen t?

Output: 1.5 Investig ation and r evascularisa tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are people wi th stab le ang ina w hose sym ptoms ar e not sa tisfactoril y controlled wi the optimal me dical treatmen t?. ### Response: 1.5 Investig ation and r evascularisa tion.


Instruction: What is another name for coronary artery bypass graft?

Output: coronar y artery bypass graft [CABG] or percutaneous cor onar y intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for coronary artery bypass graft?. ### Response: coronar y artery bypass graft [CABG] or percutaneous cor onar y intervention.


Instruction: What is the other name for percutaneous coronary intervention?

Output: PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the other name for percutaneous coronary intervention?. ### Response: PCI.


Instruction: What is satisf actorily contr olled wit h optimal medical treatment?

Output: revascularisation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is satisf actorily contr olled wit h optimal medical treatment?. ### Response: revascularisation.


Instruction: 1.5.2 Offer cor onar y angiograph y to guide tr eatment strat egy f or people wit stable angina whose sympt oms ar e not what?

Output: satisf actorily

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: 1.5.2 Offer cor onar y angiograph y to guide tr eatment strat egy f or people wit stable angina whose sympt oms ar e not what?. ### Response: satisf actorily.


Instruction: What type of testing can be used to guide treatment decisions?

Output: angiographic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of testing can be used to guide treatment decisions?. ### Response: angiographic.


Instruction: What is the NICE t echnology appraisal guidance on myocardial perfusion?

Output: scintigraph y

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the NICE t echnology appraisal guidance on myocardial perfusion?. ### Response: scintigraph y.


Instruction: What is the NICE t echnology appraisal guidance on?

Output: myocardial per fusion scintigraph y for the diagnosis and management of angina and m yocardial inf arction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the NICE t echnology appraisal guidance on?. ### Response: myocardial per fusion scintigraph y for the diagnosis and management of angina and m yocardial inf arction.


Instruction: What is a myocardial per fusion scintigraph for the diagnosis and management of?

Output: angina and m yocardial inf arction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a myocardial per fusion scintigraph for the diagnosis and management of?. ### Response: angina and m yocardial inf arction.


Instruction: What is not appr opriat e?

Output: PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not appr opriat e?. ### Response: PCI.


Instruction: What is Stable angina: management (CG126)?

Output: NICE 2022

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Stable angina: management (CG126)?. ### Response: NICE 2022.


Instruction: What is NICE 2022?

Output: Stable angina: management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE 2022?. ### Response: Stable angina: management.


Instruction: What is the subject of Notice of right s?

Output: Stable angina: management (CG126)© NICE 2022. All right s reserved

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the subject of Notice of right s?. ### Response: Stable angina: management (CG126)© NICE 2022. All right s reserved.


Instruction: When was the last updat?

Output: 25 August 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last updat?. ### Response: 25 August 2016.


Instruction: What type of discussions were convened to address the newer data?

Output: structured discussions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of discussions were convened to address the newer data?. ### Response: structured discussions.


Instruction: What did the College convene to address new thera-pies, unanswered questions, adherence, and imple-mentation strategies?

Output: structured discussions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the College convene to address new thera-pies, unanswered questions, adherence, and imple-mentation strategies?. ### Response: structured discussions.


Instruction: What was formed to provide practical guidance to address heart failure?

Output: awriting committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was formed to provide practical guidance to address heart failure?. ### Response: awriting committee.


Instruction: What was formed to address gaps in care related to optimal manage-ment of HF treatment?

Output: awriting committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was formed to address gaps in care related to optimal manage-ment of HF treatment?. ### Response: awriting committee.


Instruction: When did the writingcommittee convene for this update?

Output: mid-2020

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the writingcommittee convene for this update?. ### Response: mid-2020.


Instruction: Who attended the con fidential con-ference calls?

Output: writing committee mem-bers and ACC staff

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who attended the con fidential con-ference calls?. ### Response: writing committee mem-bers and ACC staff.


Instruction: What was implemented when consensus was deemed necessary by the Chair and Vice Chair?

Output: either a roll call vote or an email-generated ballot

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was implemented when consensus was deemed necessary by the Chair and Vice Chair?. ### Response: either a roll call vote or an email-generated ballot.


Instruction: What did the Chair's prerogative reconcile in the presence of a tie?

Output: theﬁnal decision

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Chair's prerogative reconcile in the presence of a tie?. ### Response: theﬁnal decision.


Instruction: The formal peer-review process was completed according to what?

Output: ACC policy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The formal peer-review process was completed according to what?. ### Response: ACC policy.


Instruction: What was the purpose of the peer-review process?

Output: to obtain further feedback

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the purpose of the peer-review process?. ### Response: to obtain further feedback.


Instruction: What committee approved the publication of the document?

Output: Clinical Policy ApprovalCommittee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What committee approved the publication of the document?. ### Response: Clinical Policy ApprovalCommittee.


Instruction: Who recognized the impo rtance of avoiding real orJACC VOL?

Output: The ACC and the Solution Set Oversight Committee(SSOC)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who recognized the impo rtance of avoiding real orJACC VOL?. ### Response: The ACC and the Solution Set Oversight Committee(SSOC).


Instruction: What is the impo rtance of avoiding?

Output: real

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impo rtance of avoiding?. ### Response: real.


Instruction: What does Maddox et al. 77, NO. 6, 2021 do?

Output: avoiding real or

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Maddox et al. 77, NO. 6, 2021 do?. ### Response: avoiding real or.


Instruction: How many years after the Duke criteria did Bayer re-visit his criteria for endocarditis?

Output: two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many years after the Duke criteria did Bayer re-visit his criteria for endocarditis?. ### Response: two.


Instruction: What is the name of the journal that published a study on Duke criteria in 1993?

Output: Dis Clin North Am

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that published a study on Duke criteria in 1993?. ### Response: Dis Clin North Am.


Instruction: How many patients were diagnosed with Duke's criteria in 1996?

Output: 23:303–4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were diagnosed with Duke's criteria in 1996?. ### Response: 23:303–4.


Instruction: Where can you find a copy of Bayer's study?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find a copy of Bayer's study?. ### Response: http://ahajournals.org.


Instruction: How many years later did the criteria come to be?

Output: two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many years later did the criteria come to be?. ### Response: two.


Instruction: What is the name of the journal that was downloaded from http://ahajournals.org?

Output: Clin Infect Dis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that was downloaded from http://ahajournals.org?. ### Response: Clin Infect Dis.


Instruction: What are the four main antihypertensive drug classes?

Output: intolerant to the four main antihypertensive drug classes may  also consider a beta blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the four main antihypertensive drug classes?. ### Response: intolerant to the four main antihypertensive drug classes may  also consider a beta blocker.


Instruction: What were beta blockers equivalent to for the composite cardiovascular outcomes?

Output: ARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were beta blockers equivalent to for the composite cardiovascular outcomes?. ### Response: ARBs.


Instruction: There was no significant difference between beta blocker and what other drug?

Output: CCBs or thiazide -type diuretics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There was no significant difference between beta blocker and what other drug?. ### Response: CCBs or thiazide -type diuretics.


Instruction: What type of diuretics are beta blockers compared to?

Output: CCBs or thiazide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diuretics are beta blockers compared to?. ### Response: CCBs or thiazide.


Instruction: What were no critical outcomes reported for beta blocker versus ACEIs?

Output: There

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were no critical outcomes reported for beta blocker versus ACEIs?. ### Response: There.


Instruction: Beta blockers are not recommended as what?

Output: initial antihypertensive therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Beta blockers are not recommended as what?. ### Response: initial antihypertensive therapy.


Instruction: As antihypertensive therapy, there is mixed evidence as to whether there is a clear benefit in reducing cardiovascular events?

Output: Beta blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: As antihypertensive therapy, there is mixed evidence as to whether there is a clear benefit in reducing cardiovascular events?. ### Response: Beta blockers.


Instruction: Who critically evaluated the timing for transition from inpatient antibiotic therapy to OPAT and patient exclusion criteria?

Output: Andrews and von Reyn

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who critically evaluated the timing for transition from inpatient antibiotic therapy to OPAT and patient exclusion criteria?. ### Response: Andrews and von Reyn.


Instruction: What are the guidelines based on?

Output: local availability of medical care in the outpa-tient setting and risk factors and timing of potential adverse outcomes that would be best managed in the inpatient setting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the guidelines based on?. ### Response: local availability of medical care in the outpa-tient setting and risk factors and timing of potential adverse outcomes that would be best managed in the inpatient setting.


Instruction: What would be best managed in an inpatient setting?

Output: potential adverse outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would be best managed in an inpatient setting?. ### Response: potential adverse outcomes.


Instruction: When was this document downloaded?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this document downloaded?. ### Response: April 28, 2023.


Instruction: Pase A2 and interleukin-6 have been proposed as what?

Output: risk mark-ers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Pase A2 and interleukin-6 have been proposed as what?. ### Response: risk mark-ers.


Instruction: Several studies suggest a relationship between hs-CRP and what other protein?

Output: phospholipase A2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Several studies suggest a relationship between hs-CRP and what other protein?. ### Response: phospholipase A2.


Instruction: What have epidemiological studies identified as a link between hs-CRP and stroke?

Output: elevated plasma levels of YKL-40

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have epidemiological studies identified as a link between hs-CRP and stroke?. ### Response: elevated plasma levels of YKL-40.


Instruction: What are the RRs between the highest tertiles/quartiles and the lowest?

Output: 1.5 to 2.0

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the RRs between the highest tertiles/quartiles and the lowest?. ### Response: 1.5 to 2.0.


Instruction: The association persists after adjustment for what?

Output: multiple risk factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The association persists after adjustment for what?. ### Response: multiple risk factors.


Instruction: After adjustment for multiple risk factors, hs-CRP is associated with similar increases in mortality from several cancers and what other disease?

Output: lung diseases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: After adjustment for multiple risk factors, hs-CRP is associated with similar increases in mortality from several cancers and what other disease?. ### Response: lung diseases.


Instruction: According to multiple prospective studies, what was recommended for measurement limited to?

Output: hs-CRP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: According to multiple prospective studies, what was recommended for measurement limited to?. ### Response: hs-CRP.


Instruction: What was recommended for measurement limited to people with moderate risk for coronary disease?

Output: hs-CRP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was recommended for measurement limited to people with moderate risk for coronary disease?. ### Response: hs-CRP.


Instruction: What percentage to 20% 10-year risk using the Framingham Risk Score?

Output: 10%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage to 20% 10-year risk using the Framingham Risk Score?. ### Response: 10%.


Instruction: What is YKL-40 a product of?

Output: lipid-laden macrophages

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is YKL-40 a product of?. ### Response: lipid-laden macrophages.


Instruction: What is associated with an increased risk of ischemic stroke indepen-dently of hs-CRP levels?

Output: elevated plasma levels of YKL-40

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with an increased risk of ischemic stroke indepen-dently of hs-CRP levels?. ### Response: elevated plasma levels of YKL-40.


Instruction: The JUPITER study was a randomized trial of a statin versus what?

Output: placebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The JUPITER study was a randomized trial of a statin versus what?. ### Response: placebo.


Instruction: What was the hs-CRP level?

Output: >2 mg/dL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the hs-CRP level?. ### Response: >2 mg/dL.


Instruction: What did the trial find in statin-treated patients?

Output: a reduc-tion in cardiovascular end points

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the trial find in statin-treated patients?. ### Response: a reduc-tion in cardiovascular end points.


Instruction: Who was excluded from the study?

Output: similarly treated subjects with lower lev-els of hs-CRP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was excluded from the study?. ### Response: similarly treated subjects with lower lev-els of hs-CRP.


Instruction: What did not include similarly treated subjects with lower lev-els of hs-CRP?

Output: The study design

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did not include similarly treated subjects with lower lev-els of hs-CRP?. ### Response: The study design.


Instruction: What is not available to determine the potential effects of other treatments such as aspirin in this population?

Output: data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not available to determine the potential effects of other treatments such as aspirin in this population?. ### Response: data.


Instruction: Monitoring of what has not been evaluated in randomized trials?

Output: hs-CRP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Monitoring of what has not been evaluated in randomized trials?. ### Response: hs-CRP.


Instruction: What is another way to evaluate the role of inflammation as a risk factor for cancer?

Output: hs-CRP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another way to evaluate the role of inflammation as a risk factor for cancer?. ### Response: hs-CRP.


Instruction: What is RA?

Output: rheumatoid arthritis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is RA?. ### Response: rheumatoid arthritis.


Instruction: What is SLE?

Output: systemic chronic inflammatory diseases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SLE?. ### Response: systemic chronic inflammatory diseases.


Instruction: How many prospective cohort studies have identified increased risks for CVD?

Output: A large number

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many prospective cohort studies have identified increased risks for CVD?. ### Response: A large number.


Instruction: How many premature deaths in patients with RA have been attributed to CVDs?

Output: At least 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many premature deaths in patients with RA have been attributed to CVDs?. ### Response: At least 50%.


Instruction: What was especially apparent in 35- to 55-year-old women with RA?

Output: Excess risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was especially apparent in 35- to 55-year-old women with RA?. ### Response: Excess risk.


Instruction: What was adjusted for other cardiovascular risk factors?

Output: lowest tertile/quartiles

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was adjusted for other cardiovascular risk factors?. ### Response: lowest tertile/quartiles.


Instruction: What is another name for angiotensin II-receptor-antagonists?

Output: Schaefer C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for angiotensin II-receptor-antagonists?. ### Response: Schaefer C.


Instruction: What year did Birth Defects Res Part A Clin Mol Teratol issue 67:591–4?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Birth Defects Res Part A Clin Mol Teratol issue 67:591–4?. ### Response: 2003.


Instruction: Cooper WO, Hernandez-Diaz S, Arbogast PG, et al. Major congenital mal-formations after first-trimester exposure to what?

Output: ACE inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cooper WO, Hernandez-Diaz S, Arbogast PG, et al. Major congenital mal-formations after first-trimester exposure to what?. ### Response: ACE inhibitors.


Instruction: What is the 2014 AHA/ACC/HRS guideline for the management of?

Output: pa-tients with atrial fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2014 AHA/ACC/HRS guideline for the management of?. ### Response: pa-tients with atrial fibrillation.


Instruction: What are the risks of angiotensin-converting enzyme inhibition during pregnancy?

Output: experimental and clinical evi-dence, potential mechanisms, and recommendations for use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the risks of angiotensin-converting enzyme inhibition during pregnancy?. ### Response: experimental and clinical evi-dence, potential mechanisms, and recommendations for use.