Instruction: What is the risk of major bleeding?

Output: no anti-Xa monitoring or dose adjustments

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of major bleeding?. ### Response: no anti-Xa monitoring or dose adjustments.


Instruction: What did the panel agree to use for studies with groupdindications?

Output: the outcome of major bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the panel agree to use for studies with groupdindications?. ### Response: the outcome of major bleeding.


Instruction: What would be used for the outcome of major bleeding?

Output: studies with groupedindications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would be used for the outcome of major bleeding?. ### Response: studies with groupedindications.


Instruction: What would the evidence be rated down for?

Output: indirectness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would the evidence be rated down for?. ### Response: indirectness.


Instruction: Studies with grouped indicationswere combined for the result of what?

Output: percentage of anti-Xaconcentrations in the therapeutic range

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Studies with grouped indicationswere combined for the result of what?. ### Response: percentage of anti-Xaconcentrations in the therapeutic range.


Instruction: What was not used for the outcome of PE, DVT, or mortality?

Output: Studies with grouped indications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not used for the outcome of PE, DVT, or mortality?. ### Response: Studies with grouped indications.


Instruction: What were the two LMWHs?

Output: enoxaparin and tinzaparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the two LMWHs?. ### Response: enoxaparin and tinzaparin.


Instruction: How often did the combinedstudies administer enoxaparin and tinzaparin?

Output: once daily and twice daily

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often did the combinedstudies administer enoxaparin and tinzaparin?. ### Response: once daily and twice daily.


Instruction: Chronic Heart Failure Advanced heart failure and palliative care  NICE 2018. All rights reserved. Subject to What?

Output: Notice of rights

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Chronic Heart Failure Advanced heart failure and palliative care  NICE 2018. All rights reserved. Subject to What?. ### Response: Notice of rights.


Instruction: ISBN: 978-1-4731 -3093 -7 446 10.3.5 Evidence statements Qualitative See the narrative summaries of the review findings in section 1.3.3.1.

Output: Chronic Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ISBN: 978-1-4731 -3093 -7 446 10.3.5 Evidence statements Qualitative See the narrative summaries of the review findings in section 1.3.3.1.. ### Response: Chronic Heart Failure.


Instruction: What were not sought for this review question?

Output: Health economic studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were not sought for this review question?. ### Response: Health economic studies.


Instruction: What was the last 2 to 3 days of a person entering?

Output: life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the last 2 to 3 days of a person entering?. ### Response: life.


Instruction: What is the NICE guideline on care of dying adults in the last days of life?

Output: advance care planning

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the NICE guideline on care of dying adults in the last days of life?. ### Response: advance care planning.


Instruction: What is NICE’s guidance on implantable cardioverter defibrillators?

Output: technology appraisal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE’s guidance on implantable cardioverter defibrillators?. ### Response: technology appraisal.


Instruction: What type of therapy is used for arrhythmias and heart failure?

Output: cardiac resynchronisation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is used for arrhythmias and heart failure?. ### Response: cardiac resynchronisation.


Instruction: What is the NICE guideline on patient experience in adult NHS services?

Output: shared decision making

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the NICE guideline on patient experience in adult NHS services?. ### Response: shared decision making.


Instruction: How can a person know that a defibrillator can be deactivated without affecting any cardiac resynchroni sation or pacing?

Output: many ICD recipients were not aware that their ICDs could be deactivated, with th eir doctors not discussing this with them

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can a person know that a defibrillator can be deactivated without affecting any cardiac resynchroni sation or pacing?. ### Response: many ICD recipients were not aware that their ICDs could be deactivated, with th eir doctors not discussing this with them.


Instruction: What is the guideline on patient experience in adult NHS services?

Output: shared decision making

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the guideline on patient experience in adult NHS services?. ### Response: shared decision making.


Instruction: What might be offered to dispel common misconceptions about the function of the device and the consequences of deactivation?

Output: deactivation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What might be offered to dispel common misconceptions about the function of the device and the consequences of deactivation?. ### Response: deactivation.


Instruction: Provide the person and their family or carers with written information covering the information discussed?

Output:  discuss and dispel common misconceptions about the function of the device and the consequences of deactivation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Provide the person and their family or carers with written information covering the information discussed?. ### Response:  discuss and dispel common misconceptions about the function of the device and the consequences of deactivation.


Instruction: What type of defibrillator does a person with heart failure need to remain active?

Output: cardioverter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of defibrillator does a person with heart failure need to remain active?. ### Response: cardioverter.


Instruction: How often should a heart failure patient review their heart fai lure care?

Output: 6 -monthly

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often should a heart failure patient review their heart fai lure care?. ### Response: 6 -monthly.


Instruction: What is the purpose of a 6 -monthly review?

Output: advance care planning

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of a 6 -monthly review?. ### Response: advance care planning.


Instruction: When does a person's care goals change?

Output: whenever their care goals change   as part of advance care planning if it is thought they are nearing the end of life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When does a person's care goals change?. ### Response: whenever their care goals change   as part of advance care planning if it is thought they are nearing the end of life.


Instruction: What is a part of advance care planning if they are nearing the end of life?

Output: ai lure care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a part of advance care planning if they are nearing the end of life?. ### Response: ai lure care.


Instruction: How many findings were found in the review?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many findings were found in the review?. ### Response: 3.


Instruction: How many findings were grouped into 3 findings?

Output: 3 findings, each of which contained multiple sub -findings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many findings were grouped into 3 findings?. ### Response: 3 findings, each of which contained multiple sub -findings.


Instruction: What were many ICD recipients not aware of?

Output: their ICDs could be deactivated

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were many ICD recipients not aware of?. ### Response: their ICDs could be deactivated.


Instruction: What did some ICD recipients believe to be equivalent to euthanasia or assisted suicide?

Output: deactivation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did some ICD recipients believe to be equivalent to euthanasia or assisted suicide?. ### Response: deactivation.


Instruction: What type of recipients reported that they would not consider living without their ICD?

Output: Some

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of recipients reported that they would not consider living without their ICD?. ### Response: Some.


Instruction: What did some recipients feel should never be deactivated when it could keep them alive?

Output: ICD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did some recipients feel should never be deactivated when it could keep them alive?. ### Response: ICD.


Instruction: What are some of the benefits of ACE inhibitors, ARBs, and -blockers?

Output: improve outcomes for patients with HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the benefits of ACE inhibitors, ARBs, and -blockers?. ### Response: improve outcomes for patients with HF.


Instruction: What is a significant proportion of patients with hypertension and BP treated with?

Output: HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a significant proportion of patients with hypertension and BP treated with?. ### Response: HF.


Instruction: What percentage of patients in these trials had a history of hypertension?

Output: 40%–60%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients in these trials had a history of hypertension?. ### Response: 40%–60%).


Instruction: The beneficial effects could be generalized to what population?

Output: hypertensive

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The beneficial effects could be generalized to what population?. ### Response: hypertensive.


Instruction: What have not been compelling data on?

Output: to justify a single BP target

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have not been compelling data on?. ### Response: to justify a single BP target.


Instruction: What has not been compelling to justify a single BP target in treating hypertension in patients with es-tablished HF?

Output: data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has not been compelling to justify a single BP target in treating hypertension in patients with es-tablished HF?. ### Response: data.


Instruction: Former guidelines and position papers differ significantly in what?

Output: such threshold definitions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Former guidelines and position papers differ significantly in what?. ### Response: such threshold definitions.


Instruction: What is the optimal BP target for the treat-ment of hypertension in patients with HF?

Output: not firmly established

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the optimal BP target for the treat-ment of hypertension in patients with HF?. ### Response: not firmly established.


Instruction: The 2007 AHA scientific statement recommended a target BP of 130/80 mmHg?

Output: 10.1161/CIR.0000000000000450 December 6, 2016 e539CLINICAL STATEMENTS  AND GUIDELINESremodeling, and improve LV function.57,58 Although these beneficial effects of ACE inhibitors, ARBs, and β-blockers are not specific for patients with hypertension or for treatment of BP, a significant proportion of patients in these trials (40%–60%) had a history of hypertension, and the beneficial effects could be generalized to the hypertensive population.Treatment of Hypertension in Patients With Established HF How Aggressively to Treat BP in Patients With HF?There have not been compelling data to justify a single BP target in treating hypertension in patients with es-tablished HF. Former guidelines and position papers differ significantly in such threshold definitions and lack strong evidence for treatment targets of hypertension in HF.9,14,48,59

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The 2007 AHA scientific statement recommended a target BP of 130/80 mmHg?. ### Response: 10.1161/CIR.0000000000000450 December 6, 2016 e539CLINICAL STATEMENTS  AND GUIDELINESremodeling, and improve LV function.57,58 Although these beneficial effects of ACE inhibitors, ARBs, and β-blockers are not specific for patients with hypertension or for treatment of BP, a significant proportion of patients in these trials (40%–60%) had a history of hypertension, and the beneficial effects could be generalized to the hypertensive population.Treatment of Hypertension in Patients With Established HF How Aggressively to Treat BP in Patients With HF?There have not been compelling data to justify a single BP target in treating hypertension in patients with es-tablished HF. Former guidelines and position papers differ significantly in such threshold definitions and lack strong evidence for treatment targets of hypertension in HF.9,14,48,59.


Instruction: What did ischemic heart disease recommend for patients with HF?

Output: <130/80 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did ischemic heart disease recommend for patients with HF?. ### Response: <130/80 mm Hg.


Instruction: What did the 2002 AHA Guidelines for Primary Prevention of Cardiovascular Disease and Stroke identify as the BP treatment goal?

Output: <130/85 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the 2002 AHA Guidelines for Primary Prevention of Cardiovascular Disease and Stroke identify as the BP treatment goal?. ### Response: <130/85 mm Hg.


Instruction: What was the BP threshold in patients 60 years of age?

Output: 63–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the BP threshold in patients 60 years of age?. ### Response: 63–.


Instruction: What was BP lowering too aggressive?

Output: potential adverse outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was BP lowering too aggressive?. ### Response: potential adverse outcomes.


Instruction: What was the 2014 evidence-based guideline for the management of high BP in adults?

Output: 60 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 2014 evidence-based guideline for the management of high BP in adults?. ### Response: 60 years of age.


Instruction: What did the writing committee not address in patients with es-tablished?

Output: BP treatment targets

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the writing committee not address in patients with es-tablished?. ### Response: BP treatment targets.


Instruction: What did not address BP treatment targets in patients with es-tablished HF?

Output: the writing committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did not address BP treatment targets in patients with es-tablished HF?. ### Response: the writing committee.


Instruction: What is the lack of definitive BP targets for patients with existing HF notwithstanding?

Output: treatment of HF is usu-Table 4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the lack of definitive BP targets for patients with existing HF notwithstanding?. ### Response: treatment of HF is usu-Table 4.


Instruction: What should patients with previous or current symptoms of HFrEF be treated with?

Output: GDMT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients with previous or current symptoms of HFrEF be treated with?. ### Response: GDMT.


Instruction: What is GDMT used for?

Output: Patients with previous or current symptoms of HFrEF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is GDMT used for?. ### Response: Patients with previous or current symptoms of HFrEF.


Instruction: What have been proven to improve outcomes for patients with HF?

Output: aldosterone receptor antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have been proven to improve outcomes for patients with HF?. ### Response: aldosterone receptor antagonists.


Instruction: What can lower BP in hypertensive patients?

Output: aldosterone receptor antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can lower BP in hypertensive patients?. ### Response: aldosterone receptor antagonists.


Instruction: ARB or ACE inhibitor can be added to the background treatment with what?

Output: hydralazine/isosorbide dinitrate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ARB or ACE inhibitor can be added to the background treatment with what?. ### Response: hydralazine/isosorbide dinitrate.


Instruction: What is beneficial to reduce morbidity and mortality in self-described black patients with HFrEF and persistent NYHA class III or IVHF symptoms?

Output: Addition of hydralazine/isosorbide dinitrate to the background treatment with ACE inhibitor or ARB and β-blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is beneficial to reduce morbidity and mortality in self-described black patients with HFrEF and persistent NYHA class III or IVHF symptoms?. ### Response: Addition of hydralazine/isosorbide dinitrate to the background treatment with ACE inhibitor or ARB and β-blocker.


Instruction: What is a cardiovascular composite outcome?

Output: similar rates ofmajor bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a cardiovascular composite outcome?. ### Response: similar rates ofmajor bleeding.


Instruction: What are 123NOACs compared with VKAs?

Output: NOACs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are 123NOACs compared with VKAs?. ### Response: NOACs.


Instruction: What do NOACs have a rapid onset/offset of action,absence of an effect of dietary vitamin K intake on theiractivity, and fewer drug interactions?

Output: VKAs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do NOACs have a rapid onset/offset of action,absence of an effect of dietary vitamin K intake on theiractivity, and fewer drug interactions?. ### Response: VKAs.


Instruction: What do the predictableanticoagulant effects enable theiradministration in fixed doses without the need forroutine coagulation monitoring?

Output: simplifyingtherapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do the predictableanticoagulant effects enable theiradministration in fixed doses without the need forroutine coagulation monitoring?. ### Response: simplifyingtherapy.


Instruction: In their respective phase 3 trials, what are dabigatran, rivaroxaban, etc.?

Output: apixaban, and edoxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In their respective phase 3 trials, what are dabigatran, rivaroxaban, etc.?. ### Response: apixaban, and edoxaban.


Instruction: What has been shown to be at least as safe and effective as warfarin for preventing stroke and systemic embolism in patients with AF?

Output: dabigatran, rivaroxaban, apixaban, and edoxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been shown to be at least as safe and effective as warfarin for preventing stroke and systemic embolism in patients with AF?. ### Response: dabigatran, rivaroxaban, apixaban, and edoxaban.


Instruction: What did a meta-analysis of the four phase 3 trials compare patients taking NOACs (higher dose) with?

Output: warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a meta-analysis of the four phase 3 trials compare patients taking NOACs (higher dose) with?. ### Response: warfarin.


Instruction: What did NOACs reduce by 19% compared with warfarin?

Output: stroke or systemic embolic events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did NOACs reduce by 19% compared with warfarin?. ### Response: stroke or systemic embolic events.


Instruction: What was driven primarily by a51% reduction in hemorrhagic stroke?

Output: The bene ﬁt

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was driven primarily by a51% reduction in hemorrhagic stroke?. ### Response: The bene ﬁt.


Instruction: What was similar between NOACs and warfarin?

Output: Ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was similar between NOACs and warfarin?. ### Response: Ischemic stroke.


Instruction: What was associated with a 10% reduction in all-cause mortality?

Output: NOACs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with a 10% reduction in all-cause mortality?. ### Response: NOACs.


Instruction: What was the nonsigni ficant14% reduction in major bleeding?

Output: RR, 0.86

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the nonsigni ficant14% reduction in major bleeding?. ### Response: RR, 0.86.


Instruction: The substantial 52% reduction inICH was what?

Output: RR, 0.48; 95% CI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The substantial 52% reduction inICH was what?. ### Response: RR, 0.48; 95% CI.


Instruction: NOACs were associated with what increase in gastrointestinal bleeding?

Output: ingastrointestinal bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: NOACs were associated with what increase in gastrointestinal bleeding?. ### Response: ingastrointestinal bleeding.


Instruction: What was the relative ef ficacy and safety of NOACs consistent across all patient subgroups?

Output: at least as safe and effective

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the relative ef ficacy and safety of NOACs consistent across all patient subgroups?. ### Response: at least as safe and effective.


Instruction: What was greater at centers with poor INRcontrol as de fined as a center-based TTR 66%?

Output: relative reduction in major bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was greater at centers with poor INRcontrol as de fined as a center-based TTR 66%?. ### Response: relative reduction in major bleeding.


Instruction: What was the CI of the lower dose NOAC regimens?

Output: 0.59-0.81

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the CI of the lower dose NOAC regimens?. ### Response: 0.59-0.81.


Instruction: What is the lowest dose regimenedoxaban 30/15 mg approved for?

Output: strokeprevention indication

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the lowest dose regimenedoxaban 30/15 mg approved for?. ### Response: strokeprevention indication.


Instruction: What is not approved for the strokeprevention indication?

Output: regimenedoxaban 30/15 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not approved for the strokeprevention indication?. ### Response: regimenedoxaban 30/15 mg.


Instruction: What is the outcome of the trial?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the outcome of the trial?. ### Response: RE-LY72ROCKET-AF73ARISTOTLE.


Instruction: What is the NA.001 NAGI bleedingEvent rate(%/y)1.56 1.15 1.07 2.0 1.24 0.76 0.86 1.51 0.82 1.23

Output: NA <.001 <.001

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the NA.001 NAGI bleedingEvent rate(%/y)1.56 1.15 1.07 2.0 1.24 0.76 0.86 1.51 0.82 1.23. ### Response: NA <.001 <.001.


Instruction: What should be considered for concomitant OAC?

Output: single antiplatelet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered for concomitant OAC?. ### Response: single antiplatelet.


Instruction: What do we suggest in AF patients presenting with an ACS and/orundergoing PCI/stenting?

Output: triple therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do we suggest in AF patients presenting with an ACS and/orundergoing PCI/stenting?. ### Response: triple therapy.


Instruction: What is the risk of bleeding in AF patients undergoing electivePCI/stenting?

Output: unusually high

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of bleeding in AF patients undergoing electivePCI/stenting?. ### Response: unusually high.


Instruction: How long does triple therapy last?

Output: 1 month

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does triple therapy last?. ### Response: 1 month.


Instruction: What is a better option for patients with recurrent ACS or stentthrombosis?

Output: triple therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a better option for patients with recurrent ACS or stentthrombosis?. ### Response: triple therapy.


Instruction: How long can dual therapy with OAC plus singleantiplatelet last?

Output: 12 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long can dual therapy with OAC plus singleantiplatelet last?. ### Response: 12 months.


Instruction: What can be used after 12 months of OAC monotherapy?

Output: dual therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be used after 12 months of OAC monotherapy?. ### Response: dual therapy.


Instruction: In patients requiring OAC undergoing electivePCI/stenting, where bleeding risk is high, how long can triple therapy be used?

Output: 1 month

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients requiring OAC undergoing electivePCI/stenting, where bleeding risk is high, how long can triple therapy be used?. ### Response: 1 month.


Instruction: What type of therapy can be used in AF patients undergoing electivePCI/stenting?

Output: OAC monotherapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy can be used in AF patients undergoing electivePCI/stenting?. ### Response: OAC monotherapy.


Instruction: What is a risk of bleeding unusually high for patients requiring OAC?

Output: HAS-BLED $3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk of bleeding unusually high for patients requiring OAC?. ### Response: HAS-BLED $3.


Instruction: How long is dual therapy with OAC followed by?

Output: 12 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is dual therapy with OAC followed by?. ### Response: 12 months.


Instruction: How long should you use OAC plus a single antiplatelet?

Output: 6 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long should you use OAC plus a single antiplatelet?. ### Response: 6 months.


Instruction: What is a weak recommendation, low quality evidence?

Output: HAS-BLED score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a weak recommendation, low quality evidence?. ### Response: HAS-BLED score.


Instruction: Patients at unusually high bleeding risk may include patients with what?

Output: HAS-BLED $3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients at unusually high bleeding risk may include patients with what?. ### Response: HAS-BLED $3.


Instruction: What is high thrombotic risk?

Output: left main stent, multivessel PCI/stenting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is high thrombotic risk?. ### Response: left main stent, multivessel PCI/stenting.


Instruction: What is low in AF patients requiring OAC presenting with anACS undergoing PCI/stenting?

Output: bleeding risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is low in AF patients requiring OAC presenting with anACS undergoing PCI/stenting?. ### Response: bleeding risk.


Instruction: How long do we suggest triple therapy for?

Output: 1 month

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long do we suggest triple therapy for?. ### Response: 1 month.


Instruction: What is a technique that uses inflatable cuffs wrapped around the lower part of the body?

Output: EECP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a technique that uses inflatable cuffs wrapped around the lower part of the body?. ### Response: EECP.


Instruction: What was carefully reviewed in the 2012 SIHD guideline?

Output: EECP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was carefully reviewed in the 2012 SIHD guideline?. ### Response: EECP.


Instruction: What is a technique that uses inflatable cuffs wrapped around the lower extremities to increase venous return and augment diastolic blood pressure?

Output: EECP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a technique that uses inflatable cuffs wrapped around the lower extremities to increase venous return and augment diastolic blood pressure?. ### Response: EECP.


Instruction: What is the technique that employs cuffed around the upper extremities called?

Output: Enhanced External Counterpulsation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the technique that employs cuffed around the upper extremities called?. ### Response: Enhanced External Counterpulsation.


Instruction: How are the flanges inflated sequentially from the calves to the thigh muscles?

Output: diastole

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are the flanges inflated sequentially from the calves to the thigh muscles?. ### Response: diastole.


Instruction: When are fanned instantaneously?

Output: systole

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When are fanned instantaneously?. ### Response: systole.


Instruction: What increases coronary perfusion pressure?

Output: diastolic augmentation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What increases coronary perfusion pressure?. ### Response: diastolic augmentation.


Instruction: What decreases peripheral resistance?

Output: systolic cuff depression

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What decreases peripheral resistance?. ### Response: systolic cuff depression.


Instruction: Treatment is associated with improved left ventricular diastolic filling, what?

Output: peripheral flow-mediated dila-tion, and endothelial function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Treatment is associated with improved left ventricular diastolic filling, what?. ### Response: peripheral flow-mediated dila-tion, and endothelial function.


Instruction: What do collaterals, attenuation of oxidative stress and proinflammatory cytokines have in common?

Output: improvement in symptoms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do collaterals, attenuation of oxidative stress and proinflammatory cytokines have in common?. ### Response: improvement in symptoms.


Instruction: When will the AHA Journals be available for download?

Output: May 1, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When will the AHA Journals be available for download?. ### Response: May 1, 2023.


Instruction: What is the CD003041.651?

Output: Helping smokers with cardiac disease to abstain fromtobacco after a stay in hospital

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the CD003041.651?. ### Response: Helping smokers with cardiac disease to abstain fromtobacco after a stay in hospital.


Instruction: Who helped smokers with cardiac disease to abstain from smoking after a stay in hospital?

Output: Hughes JR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who helped smokers with cardiac disease to abstain from smoking after a stay in hospital?. ### Response: Hughes JR.


Instruction: What is a randomized controlled trial for patients with coronary artery disease?

Output: Smoking cessation initiated during hospital stay

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a randomized controlled trial for patients with coronary artery disease?. ### Response: Smoking cessation initiated during hospital stay.


Instruction: How old was Peto?

Output: 20 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old was Peto?. ### Response: 20 years.


Instruction: How old were male British doctors in relation to smoking?

Output: 20 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old were male British doctors in relation to smoking?. ### Response: 20 years.


Instruction: What year did Peto retire?

Output: 1974

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Peto retire?. ### Response: 1974.


Instruction: When was the last year of Peto's retirement?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last year of Peto's retirement?. ### Response: 2005.


Instruction: What is the name of the study that analyzed smoking and risk of cardiovascular disease?

Output: Fra-mingham Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that analyzed smoking and risk of cardiovascular disease?. ### Response: Fra-mingham Study.


Instruction: What did the Fra-mingham Study reveal about smoking and cardiovascular disease in 1987?

Output: Fibrinogen, cig arettesmoking, and risk of cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Fra-mingham Study reveal about smoking and cardiovascular disease in 1987?. ### Response: Fibrinogen, cig arettesmoking, and risk of cardiovascular disease.


Instruction: How did cigarettes increase platelet function?

Output: —induced enhancement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did cigarettes increase platelet function?. ### Response: —induced enhancement.


Instruction: What did aspirinin men with coronary artery disease lack of?

Output: prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did aspirinin men with coronary artery disease lack of?. ### Response: prevention.


Instruction: What did cigarette smoking do to endothelium-dependent coronary arterial vasodilator function?

Output: impairs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did cigarette smoking do to endothelium-dependent coronary arterial vasodilator function?. ### Response: impairs.


Instruction: What is the name of the position paper from the Council on Cardio-pulmonary and Critical Care, American Heart Association?

Output: 86:699–702.659

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the position paper from the Council on Cardio-pulmonary and Critical Care, American Heart Association?. ### Response: 86:699–702.659.


Instruction: When was the Circulation.86:699–702.659 published?

Output: 1992

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circulation.86:699–702.659 published?. ### Response: 1992.


Instruction: What is nitroglycerin and calcium antagonists used for?

Output: prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is nitroglycerin and calcium antagonists used for?. ### Response: prevention.


Instruction: How soon after quitting smoking does risk of heart attack decline?

Output: 44:1247–53.661

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How soon after quitting smoking does risk of heart attack decline?. ### Response: 44:1247–53.661.


Instruction: What study did Gordon T, Kannel WB, McGee D, et al. report on?

Output: Framinghamstudy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What study did Gordon T, Kannel WB, McGee D, et al. report on?. ### Response: Framinghamstudy.


Instruction: What is a report from the Framinghamstudy?

Output: Death and coronary attacks inmen after giving up cigarette smoking

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a report from the Framinghamstudy?. ### Response: Death and coronary attacks inmen after giving up cigarette smoking.


Instruction: What is the name of the study that investigated cigarette smoking?

Output: Fra-mingham Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated cigarette smoking?. ### Response: Fra-mingham Study.


Instruction: How did the researchers evaluate the efficacy of tobacco counseling by health care providers?

Output: Meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did the researchers evaluate the efficacy of tobacco counseling by health care providers?. ### Response: Meta-analysis.


Instruction: What is the Cochrane Database Syst Rev. 2005;CD001292.665?

Output: Individual behavioural counselling for smokingcessation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Cochrane Database Syst Rev. 2005;CD001292.665?. ### Response: Individual behavioural counselling for smokingcessation.


Instruction: What does Stead LF, Lancaster T, Perera R do for smokingcessation?

Output: Telephone counselling

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Stead LF, Lancaster T, Perera R do for smokingcessation?. ### Response: Telephone counselling.


Instruction: What year did Cochrane Database Syst Rev. 2003 have a CD002850.667?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Cochrane Database Syst Rev. 2003 have a CD002850.667?. ### Response: 2005.


Instruction: What did Ussher M say about exercise interventions for smoking cessation?

Output: Exercise interventions for smoking cessation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Ussher M say about exercise interventions for smoking cessation?. ### Response: Exercise interventions for smoking cessation.


Instruction: How did Silagy C, Lancaster T, Stead L, et al. feel about nicotine replacement therapy?

Output: smoking cessation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Silagy C, Lancaster T, Stead L, et al. feel about nicotine replacement therapy?. ### Response: smoking cessation.


Instruction: What is recommended in individuals with overweight and obesity to improve the ASCVD risk factor profile?

Output: weight loss

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended in individuals with overweight and obesity to improve the ASCVD risk factor profile?. ### Response: weight loss.


Instruction: What are counseling and comprehensive lifestyle interventions recommended for?

Output: achieving and maintaining weight loss in adults with overweight and obesity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are counseling and comprehensive lifestyle interventions recommended for?. ### Response: achieving and maintaining weight loss in adults with overweight and obesity.


Instruction: What is recommended to identify adults with overweight and obesity for weight loss considerations?

Output: Calculating body mass index (BMI)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended to identify adults with overweight and obesity for weight loss considerations?. ### Response: Calculating body mass index (BMI).


Instruction: What is a reasonable measure to identify those at higher waist circumference?

Output: B-NR4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a reasonable measure to identify those at higher waist circumference?. ### Response: B-NR4.


Instruction: What is reasonable to measure to identify those at higher cardiometabolic risk?

Output: waist circumference

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable to measure to identify those at higher cardiometabolic risk?. ### Response: waist circumference.


Instruction: Adults With Type 2 Diabetes MellitusSee Figure 2 for an algorithm for treatment of what?

Output: T2DM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Adults With Type 2 Diabetes MellitusSee Figure 2 for an algorithm for treatment of what?. ### Response: T2DM.


Instruction: How many h/d do US adults spend on average in sedentary activities?

Output: >7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many h/d do US adults spend on average in sedentary activities?. ### Response: >7.


Instruction: What is the name of the study that changed the data from Young et al.S3.2-12?

Output: ahajournals.org

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that changed the data from Young et al.S3.2-12?. ### Response: ahajournals.org.


Instruction: On what date was the data modified?

Output: May 1, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On what date was the data modified?. ### Response: May 1, 2023.


Instruction: Database Syst Rev. 2012;4:CD002042. 700. Carson JL, Grossman BJ, Kleinman S, et al. Red blood cell transfusion: a clin-ical practice guideline from the AABB. Ann Intern Med 2012;157:49–58. 700. Rao SV, Jollis JG, Harrington RA, and what other person have a relationship of blood transfusion and clinical outcomes in patients with acute coronary disease?

Output: 701

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Database Syst Rev. 2012;4:CD002042. 700. Carson JL, Grossman BJ, Kleinman S, et al. Red blood cell transfusion: a clin-ical practice guideline from the AABB. Ann Intern Med 2012;157:49–58. 700. Rao SV, Jollis JG, Harrington RA, and what other person have a relationship of blood transfusion and clinical outcomes in patients with acute coronary disease?. ### Response: 701.


Instruction: What is the name of the journal that describes blood transfusion and clinical outcomes in patients with acute coronary syndromes?

Output: JAMA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that describes blood transfusion and clinical outcomes in patients with acute coronary syndromes?. ### Response: JAMA.


Instruction: When was JAMA's 292:1555-62 published?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was JAMA's 292:1555-62 published?. ### Response: 2004.


Instruction: What are the implications of transfusion practice and out-comes in non-ST-segment elevation?

Output: results from the CRUSADE National Quality Improvement Initiative

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the implications of transfusion practice and out-comes in non-ST-segment elevation?. ### Response: results from the CRUSADE National Quality Improvement Initiative.


Instruction: What are the implications of blood transfusions for patients with non-ST-segment elevation acute coronary syn-dromes?

Output: results from the CRUSADE National Quality Improvement Initiative

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the implications of blood transfusions for patients with non-ST-segment elevation acute coronary syn-dromes?. ### Response: results from the CRUSADE National Quality Improvement Initiative.


Instruction: What is the result of the CRUSADE National Quality Improvement Initiative?

Output: The implications of blood trans-fusions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the result of the CRUSADE National Quality Improvement Initiative?. ### Response: The implications of blood trans-fusions.


Instruction: When was the J Am Coll Cardiol.46:1490-5. 704. Sabatine MS, Morrow DA, Giugliano RP, et al. association of hemo-globin levels with what?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol.46:1490-5. 704. Sabatine MS, Morrow DA, Giugliano RP, et al. association of hemo-globin levels with what?. ### Response: 2005.


Instruction: What is the association of hemo-globin levels with clinical outcomes in acute coronary syndromes?

Output: 704

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association of hemo-globin levels with clinical outcomes in acute coronary syndromes?. ### Response: 704.


Instruction: Circulation. 2005;111:2042–9.

Output: Association of hemo-globin levels with clinical outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation. 2005;111:2042–9.. ### Response: Association of hemo-globin levels with clinical outcomes.


Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al.


Instruction: What is the DOI: 10.1161/CIR.0000000000000923 February 2, 2021?

Output: Otto et al 2020 ACC/AHA Guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the DOI: 10.1161/CIR.0000000000000923 February 2, 2021?. ### Response: Otto et al 2020 ACC/AHA Guideline.


Instruction: What was the difference in all-cause mortality rate at 6 months in the early surgery group versus the conven-tional treatment groups?

Output: 3% and 5%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the difference in all-cause mortality rate at 6 months in the early surgery group versus the conven-tional treatment groups?. ### Response: 3% and 5%,.


Instruction: What was a marked reduction in the number of embolic events?

Output: 0% in the early surgery group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a marked reduction in the number of embolic events?. ### Response: 0% in the early surgery group.


Instruction: What percentage of the conventional treatment group required surgery during the initial hospitalization or during the follow-up phase?

Output: 77%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the conventional treatment group required surgery during the initial hospitalization or during the follow-up phase?. ### Response: 77%.


Instruction: What is an independent risk factor for postoperative death in patients with HF?

Output: age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an independent risk factor for postoperative death in patients with HF?. ### Response: age.


Instruction: What is an independent risk factor for postoperative death in patients with IE?

Output: Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an independent risk factor for postoperative death in patients with IE?. ### Response: Stroke.


Instruction: What is hindered by the lack of RCTs and reliance on single-center experiences?

Output: Recommendations about the timing of opera-tive intervention after a stroke in the setting of IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hindered by the lack of RCTs and reliance on single-center experiences?. ### Response: Recommendations about the timing of opera-tive intervention after a stroke in the setting of IE.


Instruction: In early observa-tional data, there was a significantly decreased risk of what?

Output: in-hospital death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In early observa-tional data, there was a significantly decreased risk of what?. ### Response: in-hospital death.


Instruction: What was the risk of in-hospital death when surgery was per -formed >4 weeks after the stroke?

Output: decreased

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk of in-hospital death when surgery was per -formed >4 weeks after the stroke?. ### Response: decreased.


Instruction: What was not risk adjusted in an observational study?

Output: RCTs and reliance on single-center experiences. In early observa-tional data, there was a significantly decreased risk of in-hospital death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not risk adjusted in an observational study?. ### Response: RCTs and reliance on single-center experiences. In early observa-tional data, there was a significantly decreased risk of in-hospital death.


Instruction: What risk of in-hospital death was not significantly higher in the group who underwent surgery within a median time from admission to operation of 5 days?

Output: the risk of in-hospital death was not significantly higher in the group who underwent surgery within a median time from admission to operation of 5 days, with only a 1% risk of perioperative hemorrhagic conversion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What risk of in-hospital death was not significantly higher in the group who underwent surgery within a median time from admission to operation of 5 days?. ### Response: the risk of in-hospital death was not significantly higher in the group who underwent surgery within a median time from admission to operation of 5 days, with only a 1% risk of perioperative hemorrhagic conversion.


Instruction: What was the risk of perioperative hemorrhagic conversion?

Output: 1%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk of perioperative hemorrhagic conversion?. ### Response: 1%.


Instruction: How long did it take to undergo surgery?

Output: 5 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take to undergo surgery?. ### Response: 5 days.


Instruction: How long after a hemorrhagic stroke do patients with IE have a prohibitively high surgical risk?

Output: 4 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after a hemorrhagic stroke do patients with IE have a prohibitively high surgical risk?. ### Response: 4 weeks.


Instruction: What did one multicenter observational study71 show?

Output: wide variation in patient deaths

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did one multicenter observational study71 show?. ### Response: wide variation in patient deaths.


Instruction: What was the percentage of new postop-erative bleeds in patients whose surgery was performed in the first 2 weeks?

Output: 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the percentage of new postop-erative bleeds in patients whose surgery was performed in the first 2 weeks?. ### Response: 50%.


Instruction: What percentage of patients had surgery done in the third week?

Output: 33%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients had surgery done in the third week?. ### Response: 33%.


Instruction: What percentage of patients had surgery performed in the third week?

Output: 33%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients had surgery performed in the third week?. ### Response: 33%.


Instruction: What percentage had surgery done at least 21 days after the neuro-logical event?

Output: 20%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage had surgery done at least 21 days after the neuro-logical event?. ### Response: 20%.


Instruction: PREGNANCY AND VHDThe physiological hemodynamic changes associated with pregnancy are generally well tolerated in women with what?

Output: structurally normal hearts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: PREGNANCY AND VHDThe physiological hemodynamic changes associated with pregnancy are generally well tolerated in women with what?. ### Response: structurally normal hearts.


Instruction: What may pose signifi-cant challenges during pregnancy and delivery for women with VHD?

Output: the hemodynamic burden

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may pose signifi-cant challenges during pregnancy and delivery for women with VHD?. ### Response: the hemodynamic burden.


Instruction: What are recommendations for Initial Management of Women With VHD Before and During Pregnancy?

Output: Referenced studies that support the recommendations are summarized in Online Data Supplement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are recommendations for Initial Management of Women With VHD Before and During Pregnancy?. ### Response: Referenced studies that support the recommendations are summarized in Online Data Supplement.


Instruction: Where are the studies that support the recommendations summarized?

Output: Online Data Supplement 43

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are the studies that support the recommendations summarized?. ### Response: Online Data Supplement 43.


Instruction: Women with suspected valve disease who are considering pregnancy should undergo what before pregnancy?

Output: a clinical evaluation and TTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Women with suspected valve disease who are considering pregnancy should undergo what before pregnancy?. ### Response: a clinical evaluation and TTE.


Instruction: What are some monitors that have a substantial controversy about their use?

Output: pulmonary artery rupture with PAC, false-positive changes with cerebral oximetry or processed electro-encephalogram

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some monitors that have a substantial controversy about their use?. ### Response: pulmonary artery rupture with PAC, false-positive changes with cerebral oximetry or processed electro-encephalogram.


Instruction: None of these monitoring methods is recommended what?

Output: routinely recommended

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: None of these monitoring methods is recommended what?. ### Response: routinely recommended.


Instruction: Electrocardiographic monitoring includes an assessment of what two things?

Output: heart rate and rhythm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Electrocardiographic monitoring includes an assessment of what two things?. ### Response: heart rate and rhythm.


Instruction: What is telemetric monitoring recommended for 48 to 72 hours after surgery in all patients?

Output: cardiac rate and rhythm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is telemetric monitoring recommended for 48 to 72 hours after surgery in all patients?. ### Response: cardiac rate and rhythm.


Instruction: What is the high incidence of post-CABG AF?

Output: mostoften occurs 2 and 4 days after surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the high incidence of post-CABG AF?. ### Response: mostoften occurs 2 and 4 days after surgery.


Instruction: Post-CABG AF usually occurs how many days after surgery?

Output: 2 and 4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Post-CABG AF usually occurs how many days after surgery?. ### Response: 2 and 4.


Instruction: Other arrhythmias and conduction abnormalities may occur in patients with what?

Output: ischemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Other arrhythmias and conduction abnormalities may occur in patients with what?. ### Response: ischemia.


Instruction: What continues with regard to the utility of PAC?

Output: Uncertainty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What continues with regard to the utility of PAC?. ### Response: Uncertainty.


Instruction: What can be managed withmonitoring of central venous pressure?

Output: low-risk patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be managed withmonitoring of central venous pressure?. ### Response: low-risk patients.


Instruction: What can insertion of aPAC held in reserve should the need arise?

Output: monitoring of central venous pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can insertion of aPAC held in reserve should the need arise?. ### Response: monitoring of central venous pressure.


Instruction: What is PAC placed incur?

Output: er resource utilization and more aggressive therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PAC placed incur?. ### Response: er resource utilization and more aggressive therapy.


Instruction: What may lead to worse outcomes and higher costs?

Output: incurgreater resource utilization and more aggressive therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may lead to worse outcomes and higher costs?. ### Response: incurgreater resource utilization and more aggressive therapy.


Instruction: In a combinedprivate-academic setting, what is the rate of PAC use?

Output: /H1102110%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In a combinedprivate-academic setting, what is the rate of PAC use?. ### Response: /H1102110%.


Instruction: What can be used to measure cardiac output?

Output: PAC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be used to measure cardiac output?. ### Response: PAC.


Instruction: What is PAC used to monitor?

Output: cerebral function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PAC used to monitor?. ### Response: cerebral function.


Instruction: What is the need for careful consid-eration of baseline patient risk, the planned procedure and the patient setting before use of a PAC outlined in several opinions pieces?

Output: 712,714

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the need for careful consid-eration of baseline patient risk, the planned procedure and the patient setting before use of a PAC outlined in several opinions pieces?. ### Response: 712,714.


Instruction: What are the Practice Guide-lines for Pulmonary Artery Catheterization: An Updated Report by the American Society of Anesthesiologists?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Practice Guide-lines for Pulmonary Artery Catheterization: An Updated Report by the American Society of Anesthesiologists?. ### Response: “.


Instruction: What is the name of the 2009 ACCF/AHA Focused Update on PerioperativeBeta Blockade Incorporated into the 2007 Guide-lines on Noncardiac Surgery?

Output: 2009 ACCF/AHA Focused Update

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2009 ACCF/AHA Focused Update on PerioperativeBeta Blockade Incorporated into the 2007 Guide-lines on Noncardiac Surgery?. ### Response: 2009 ACCF/AHA Focused Update.


Instruction: Pulmonary artery per-foration or rupture is fatal in what percentage of patients?

Output: /H1102250%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Pulmonary artery per-foration or rupture is fatal in what percentage of patients?. ### Response: /H1102250%.


Instruction: What can be avoided by 1)withdrawal from surgery?

Output: Pulmonary artery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be avoided by 1)withdrawal from surgery?. ### Response: Pulmonary artery.


Instruction: What can be avoided by 1)drawing the catheter tip into the main pulmonary artery before initiation of CPB?

Output: Pulmonary artery per-foration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be avoided by 1)drawing the catheter tip into the main pulmonary artery before initiation of CPB?. ### Response: Pulmonary artery per-foration.


Instruction: 2) withdrawal of the catheter into the pulmonary arterial before balloon inflation, especially if pressure tracing suggests damping?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: 2) withdrawal of the catheter into the pulmonary arterial before balloon inflation, especially if pressure tracing suggests damping?. ### Response: 2.


Instruction: What is a specific diagnostic event?

Output: avoidingroutine measurement of the pulmonary artery wedge pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a specific diagnostic event?. ### Response: avoidingroutine measurement of the pulmonary artery wedge pressure.


Instruction: What is the primary goal of perioperative monitoring of cerebral function?

Output: specific diagnostic event

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary goal of perioperative monitoring of cerebral function?. ### Response: specific diagnostic event.


Instruction: What is the 2018 ACHD GuidelineCirculation. 2019;139:e698–e800?

Output: Stout et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2018 ACHD GuidelineCirculation. 2019;139:e698–e800?. ### Response: Stout et al.


Instruction: What is BACKGROUND AND PATHOPHYSIOLOGY2.1?

Output: Anatomic and Physiological Terms S2.1-1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is BACKGROUND AND PATHOPHYSIOLOGY2.1?. ### Response: Anatomic and Physiological Terms S2.1-1.


Instruction: Who wrote the report from the International Society for Nomenclature of Paediatric and Congenital Heart Disease?

Output: Bergersen L, Giroud JM, Jacobs JP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote the report from the International Society for Nomenclature of Paediatric and Congenital Heart Disease?. ### Response: Bergersen L, Giroud JM, Jacobs JP.


Instruction: What is the name of the visual encyclopedia created by the International Society for Nomenclature of Paediatric and Congenital Heart Disease?

Output: S2.1-6. International Society for Nomenclature of Paediatric and Congenital Heart Disease. International Paediatric and Congenital Cardiac Code. Available at: http://ipccc.net

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the visual encyclopedia created by the International Society for Nomenclature of Paediatric and Congenital Heart Disease?. ### Response: S2.1-6. International Society for Nomenclature of Paediatric and Congenital Heart Disease. International Paediatric and Congenital Cardiac Code. Available at: http://ipccc.net.


Instruction: What are the terms and definitions of the international pediatric and congenital cardiac code?

Output: visual encyclopedia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the terms and definitions of the international pediatric and congenital cardiac code?. ### Response: visual encyclopedia.


Instruction: When was the World J Pediatr Congenit Heart Surg published?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the World J Pediatr Congenit Heart Surg published?. ### Response: 2010.


Instruction: What is part 2 of the report on catheterisation for congenital and paediatric cardiac disease?

Output: Nomenclature of complications associated with interventional cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is part 2 of the report on catheterisation for congenital and paediatric cardiac disease?. ### Response: Nomenclature of complications associated with interventional cardiology.


Instruction: What are the complications associated with interventional cardiology?

Output: Nomenclature

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the complications associated with interventional cardiology?. ### Response: Nomenclature.


Instruction: What is the name of the group that published a report on catheterisation for congenital and paediatric cardiac disease?

Output: International Society for Nomenclature of Paediatric and Congenital Heart Disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that published a report on catheterisation for congenital and paediatric cardiac disease?. ### Response: International Society for Nomenclature of Paediatric and Congenital Heart Disease.


Instruction: What was the title of the report?

Output: Writing Committee to Develop Guidelines on the Management of Adults With Congenital Heart Disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the title of the report?. ### Response: Writing Committee to Develop Guidelines on the Management of Adults With Congenital Heart Disease.


Instruction: What is the International Pediatric and Congenital Cardiac Code?

Output: Nomenclature for con-genital and paediatric cardiac disease: historical perspectives and The International Pediatric and Congenital Cardiac Code. Cardiol Young. 2008;18 suppl 2:70–80. S2.1-5. Franklin RCG, Béland MJ, Krogmann ON. Mapping and coding of nomenclatures for paediatric and congenital heart disease. Cardiol Young. 2006;16:105–6. S2.1-6. International Society for Nomenclature of Paediatric and Congenital Heart Disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the International Pediatric and Congenital Cardiac Code?. ### Response: Nomenclature for con-genital and paediatric cardiac disease: historical perspectives and The International Pediatric and Congenital Cardiac Code. Cardiol Young. 2008;18 suppl 2:70–80. S2.1-5. Franklin RCG, Béland MJ, Krogmann ON. Mapping and coding of nomenclatures for paediatric and congenital heart disease. Cardiol Young. 2006;16:105–6. S2.1-6. International Society for Nomenclature of Paediatric and Congenital Heart Disease.


Instruction: What is a historical perspective on nomenclature for con-genital and paediatric cardiac disease?

Output: The International Pediatric and Congenital Cardiac Code

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a historical perspective on nomenclature for con-genital and paediatric cardiac disease?. ### Response: The International Pediatric and Congenital Cardiac Code.


Instruction: When was the 18 suppl 2 of Cardiol Young published?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the 18 suppl 2 of Cardiol Young published?. ### Response: 2008.


Instruction: What is the acronym for paediatric and congenital heart disease?

Output: International Society for Nomenclature of Paediatric and Congenital Heart Disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for paediatric and congenital heart disease?. ### Response: International Society for Nomenclature of Paediatric and Congenital Heart Disease.


Instruction: What are the guidelines for the management of ACHD?

Output: 775CLINICAL STATEMENTS  AND GUIDELINES

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the guidelines for the management of ACHD?. ### Response: 775CLINICAL STATEMENTS  AND GUIDELINES.


Instruction: Where can you find the ACC/AHA 2008 guide-lines?

Output: Circulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find the ACC/AHA 2008 guide-lines?. ### Response: Circulation.


Instruction: What is the name of the Task Force on Practice Guidelines?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Practice Guidelines?. ### Response: American Heart Association.


Instruction: What are the 2008 guidelines for the management of adults with congenital heart disease?

Output: ACC/AHA 2008 guide-lines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the 2008 guidelines for the management of adults with congenital heart disease?. ### Response: ACC/AHA 2008 guide-lines.


Instruction: What is the name of the group that developed the 2014 AHA/ACC guideline for the management of patients with valvular heart di-sease?

Output: American College of Cardiology/American Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that developed the 2014 AHA/ACC guideline for the management of patients with valvular heart di-sease?. ### Response: American College of Cardiology/American Heart Association Task Force on Practice Guidelines.


Instruction: What is the Canadian Cardiovascular Society's position statement on the management of thoracic aortic disease?

Output: S2.2-3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Canadian Cardiovascular Society's position statement on the management of thoracic aortic disease?. ### Response: S2.2-3.


Instruction: What are the guidelines for management and quality of Aortic valve and as-cending Aorta?

Output: Aortic valve and as-cending aorta guidelines for management and quality measures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the guidelines for management and quality of Aortic valve and as-cending Aorta?. ### Response: Aortic valve and as-cending aorta guidelines for management and quality measures.


Instruction: What are guidelines for management and quality measures?

Output: Aortic valve and as-cending aorta

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are guidelines for management and quality measures?. ### Response: Aortic valve and as-cending aorta.


Instruction: What is the title of the 2013 issue of Ann Thorac Surg?

Output: 95:S1–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of the 2013 issue of Ann Thorac Surg?. ### Response: 95:S1–.


Instruction: What year was the Cholesterol Clinical Practice Guidelines published?

Output: 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the Cholesterol Clinical Practice Guidelines published?. ### Response: 2018.


Instruction: What is the name of the professor and vice chair at the University of Colorado?

Output: Joseph Saseen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor and vice chair at the University of Colorado?. ### Response: Joseph Saseen.


Instruction: Who is the professor of medicine at the University of North Carolina, Chapel Hill?

Output: Sidney C. Smith, Jr

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the professor of medicine at the University of North Carolina, Chapel Hill?. ### Response: Sidney C. Smith, Jr.


Instruction: What is the name of the professor at the Rollins School of Public Health at Emory University?

Output: Laurence S. Sperling

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor at the Rollins School of Public Health at Emory University?. ### Response: Laurence S. Sperling.


Instruction: Where is Salim Virani Baylor College of Medicine?

Output: —Professor, Section of Cardiovascular Research and Director, Cardiology Fellowship Training Program

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Salim Virani Baylor College of Medicine?. ### Response: —Professor, Section of Cardiovascular Research and Director, Cardiology Fellowship Training Program.


Instruction: Who is Virani Baylor College of Medicine?

Output: Salim S. Virani Baylor College of Medicine—Professor, Section of Cardiovascular Research and Director, Cardiology Fellowship Training Program

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Virani Baylor College of Medicine?. ### Response: Salim S. Virani Baylor College of Medicine—Professor, Section of Cardiovascular Research and Director, Cardiology Fellowship Training Program.


Instruction: What is Michael E. DeBakey VA Medical Center's job title?

Output: Staff Cardiologist and Investigator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Michael E. DeBakey VA Medical Center's job title?. ### Response: Staff Cardiologist and Investigator.


Instruction: Who is Joseph Yeboah Wake Forest Baptist Health's position?

Output: Assistant Professor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Joseph Yeboah Wake Forest Baptist Health's position?. ### Response: Assistant Professor.


Instruction: Who is Assistant Professor, Internal Medicine, Cardiovascular?

Output: Joseph Yeboah Wake Forest Baptist Health

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Assistant Professor, Internal Medicine, Cardiovascular?. ### Response: Joseph Yeboah Wake Forest Baptist Health.


Instruction: What table represents the relationships of committee members with industry and other entities that were determined to be relevant?

Output: This table

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What table represents the relationships of committee members with industry and other entities that were determined to be relevant?. ### Response: This table.


Instruction: What was reviewed and updated in conjunction with all meetings and/or conference calls of the writing committee during the document development process?

Output: relationships of committee members with industry and other entities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was reviewed and updated in conjunction with all meetings and/or conference calls of the writing committee during the document development process?. ### Response: relationships of committee members with industry and other entities.


Instruction: What does not necessarily reflect relationships with industry at the time of publication?

Output: The table

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not necessarily reflect relationships with industry at the time of publication?. ### Response: The table.


Instruction: What percentage of the voting stock or share of the business entity does the interest represent ownership of?

Output: ≥5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the voting stock or share of the business entity does the interest represent ownership of?. ### Response: ≥5%.


Instruction: How much of the fair market value of a business entity is owned by the person if the interest in the business represents ownership of 5%?

Output: ≥$5 000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the fair market value of a business entity is owned by the person if the interest in the business represents ownership of 5%?. ### Response: ≥$5 000.


Instruction: What is the amount of money received by a person from a company that exceeds the value of the company?

Output: 5% of the person’s gross income for the previous year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the amount of money received by a person from a company that exceeds the value of the company?. ### Response: 5% of the person’s gross income for the previous year.


Instruction: How much of a person's gross income does a business entity receive?

Output: 5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of a person's gross income does a business entity receive?. ### Response: 5%.


Instruction: What is included in the table for the purpose of transparency?

Output: Relationships that exist with no financial benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is included in the table for the purpose of transparency?. ### Response: Relationships that exist with no financial benefit.


Instruction: What does the ACC/AHA say a person has a relevant relationship with?

Output: IF: a) the relationship or interest relates to the same or similar subject matter, intellectual property or asset, topic, or issue addressed in the document

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the ACC/AHA say a person has a relevant relationship with?. ### Response: IF: a) the relationship or interest relates to the same or similar subject matter, intellectual property or asset, topic, or issue addressed in the document.


Instruction: What does a relationship or interest relate to?

Output: the same or similar subject matter, intellectual property or asset, topic, or issue addressed in the document

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does a relationship or interest relate to?. ### Response: the same or similar subject matter, intellectual property or asset, topic, or issue addressed in the document.


Instruction: Who makes a drug, drug class, or device addressed in the document?

Output: the company/entity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who makes a drug, drug class, or device addressed in the document?. ### Response: the company/entity.


Instruction: Who has a reasonable potential for financial, professional, or other damages?

Output: the person or a member of the person’s household

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who has a reasonable potential for financial, professional, or other damages?. ### Response: the person or a member of the person’s household.


Instruction: When did the Cholesterol Guideline begin?

Output: September 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Cholesterol Guideline begin?. ### Response: September 2016.


Instruction: The ACC and AHA have not considered these minor charges relevant to what?

Output: food and beverage payments

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The ACC and AHA have not considered these minor charges relevant to what?. ### Response: food and beverage payments.


Instruction: Powers and al 2019 Guidelines for Management of AIS e3936.6. Antithrombotic Treatment6.6.1. Noncardioembolic Stroke COR LOE New, Revised, or Unchanged What is the use of antiplatelet agents rather than oral anticoagulation recommended for?

Output: reduce the risk of recurrent stroke and other cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Powers and al 2019 Guidelines for Management of AIS e3936.6. Antithrombotic Treatment6.6.1. Noncardioembolic Stroke COR LOE New, Revised, or Unchanged What is the use of antiplatelet agents rather than oral anticoagulation recommended for?. ### Response: reduce the risk of recurrent stroke and other cardiovascular events.


Instruction: What year was the I ARecommendation reworded for clarity?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the I ARecommendation reworded for clarity?. ### Response: 2014.


Instruction: COR and LOE remain unchanged.

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: COR and LOE remain unchanged.. ### Response: 2.


Instruction: What should be selected for early secondary prevention in patients with noncardioembolic AIS?

Output: antiplatelet agent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be selected for early secondary prevention in patients with noncardioembolic AIS?. ### Response: antiplatelet agent.


Instruction: What should the selection of an antiplatelet agent be individualized on?

Output: patient risk factor profiles, cost, tolerance, relative known efficacy of the agents, and other clinical characteristics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should the selection of an antiplatelet agent be individualized on?. ### Response: patient risk factor profiles, cost, tolerance, relative known efficacy of the agents, and other clinical characteristics.


Instruction: What should patient risk factor profiles, cost, tolerance, relative known efficacy of the agents, and other clinical characteristics be?

Output: individualized

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patient risk factor profiles, cost, tolerance, relative known efficacy of the agents, and other clinical characteristics be?. ### Response: individualized.


Instruction: I C-EORecommendation reworded for clarity from what year?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: I C-EORecommendation reworded for clarity from what year?. ### Response: 2014.


Instruction: What is the COR unchanged?

Output: LOE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the COR unchanged?. ### Response: LOE.


Instruction: What was the LOE amended to conform with?

Output: ACC/AHA 2015 Recommendation Classification System

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the LOE amended to conform with?. ### Response: ACC/AHA 2015 Recommendation Classification System.


Instruction: Where is the original wording of Table XCV?

Output: online Data Supplement 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the original wording of Table XCV?. ### Response: online Data Supplement 1.


Instruction: What is not well established in secondary stroke prevention?

Output: switching to an alternative antiplatelet agent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not well established in secondary stroke prevention?. ### Response: switching to an alternative antiplatelet agent.


Instruction: When was the IIb B-RRecommendation revised?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the IIb B-RRecommendation revised?. ### Response: 2014.


Instruction: What is the therapeutic benefit of aspirin in noncardioembolic ischemic stroke?

Output: similar across a wide range of doses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the therapeutic benefit of aspirin in noncardioembolic ischemic stroke?. ### Response: similar across a wide range of doses.


Instruction: What does the hemorrhagic risk increase with higher doses?

Output: aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the hemorrhagic risk increase with higher doses?. ### Response: aspirin.


Instruction: What is not well established in patients taking aspirin at the time of an incident stroke?

Output: the benefit of switching to an alternative antiplatelet agent or combination therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not well established in patients taking aspirin at the time of an incident stroke?. ### Response: the benefit of switching to an alternative antiplatelet agent or combination therapy.


Instruction: The SPS3 RCT found no benefit from what?

Output: adding clopidogrel to aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The SPS3 RCT found no benefit from what?. ### Response: adding clopidogrel to aspirin.


Instruction: What did the SPS3 trial find no benefit from adding clopidogrel to aspirin compared with placebo?

Output: patients with a recent small vessel, lacunar stroke taking aspirin at the time of their index event

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the SPS3 trial find no benefit from adding clopidogrel to aspirin compared with placebo?. ### Response: patients with a recent small vessel, lacunar stroke taking aspirin at the time of their index event.


Instruction: What was the median time from the qualifying event to enrollment in the trial?

Output: >40 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the median time from the qualifying event to enrollment in the trial?. ### Response: >40 days.