Instruction: How old were the patients who received aortic valve replacement?

Output: 50 to 70 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old were the patients who received aortic valve replacement?. ### Response: 50 to 70 years.


Instruction: What did Kappetein AP and Lam B-K weigh against reoperation risk?

Output: lifetime anticoagulant-related event risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Kappetein AP and Lam B-K weigh against reoperation risk?. ### Response: lifetime anticoagulant-related event risk.


Instruction: What was the J Thorac Cardiovasc Surg. 2009;137:881–6, 866.e1–5?

Output: Aortic valve replacement in patients aged 50 to 70 years: improved outcome with mechanical versus biologic prostheses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the J Thorac Cardiovasc Surg. 2009;137:881–6, 866.e1–5?. ### Response: Aortic valve replacement in patients aged 50 to 70 years: improved outcome with mechanical versus biologic prostheses.


Instruction: What is the difference between mechanical versus bioprosthetic valve replacement in middle-aged patients?

Output: improved outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between mechanical versus bioprosthetic valve replacement in middle-aged patients?. ### Response: improved outcome.


Instruction: What year did Eur J Cardiothorac Surg.30:485–91?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Eur J Cardiothorac Surg.30:485–91?. ### Response: 2006.


Instruction: How old are patients with aortic valve replacements?

Output: 50 to 70 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old are patients with aortic valve replacements?. ### Response: 50 to 70 years.


Instruction: What is the age range of patients who undergo a bioprosthetic vs mechanical mitral valve replacement?

Output: 50 to 69 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the age range of patients who undergo a bioprosthetic vs mechanical mitral valve replacement?. ### Response: 50 to 69 years.


Instruction: When did the JAMA issue 313:1435-42?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the JAMA issue 313:1435-42?. ### Response: 2015.


Instruction: What was the name of the study that compared the late outcomes of nonelderly patients with stented biopropsthetic and mechanical valves?

Output: J Thorac Cardiovasc

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the study that compared the late outcomes of nonelderly patients with stented biopropsthetic and mechanical valves?. ### Response: J Thorac Cardiovasc.


Instruction: What is a propensity-matched analysis of nonelderly patients with stented bioprosthetic and mechanical valves in the aortic position?

Output: Late outcomes comparison

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a propensity-matched analysis of nonelderly patients with stented bioprosthetic and mechanical valves in the aortic position?. ### Response: Late outcomes comparison.


Instruction: What is the name of the study that compares the survival and long-term out-comes following a prosthetic vs mechanical Aortic valve replacement in patients aged 50 to 69 years?

Output: JAMA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that compares the survival and long-term out-comes following a prosthetic vs mechanical Aortic valve replacement in patients aged 50 to 69 years?. ### Response: JAMA.


Instruction: What is the age range for aortic valve replacement in patients?

Output: 50 to 70 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the age range for aortic valve replacement in patients?. ### Response: 50 to 70 years.


Instruction: How old are patients with mitral valve replacement?

Output: 50 to 69 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old are patients with mitral valve replacement?. ### Response: 50 to 69 years.


Instruction: What are the benefits of mechanical versus bioprosthetic valve replacements?

Output: improved outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the benefits of mechanical versus bioprosthetic valve replacements?. ### Response: improved outcome.


Instruction: What is the Carpentier-Edwards pericardial bio-marker used for?

Output: mitral valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Carpentier-Edwards pericardial bio-marker used for?. ### Response: mitral valve replacement.


Instruction: What is masked uncontrolled hypertension?

Output: Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is masked uncontrolled hypertension?. ### Response: Hypertension.


Instruction: What should out-of-fence monitoring be performed for?

Output: detecting white coat hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should out-of-fence monitoring be performed for?. ### Response: detecting white coat hypertension.


Instruction: How many hours ambulatoryblood pressure patterns are associated with cognitive function and physicalfunctioning?

Output: 24

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many hours ambulatoryblood pressure patterns are associated with cognitive function and physicalfunctioning?. ### Response: 24.


Instruction: What are the patterns with cognitive function and physicalfunctioning in CKD?

Output: 24-hour ambulatoryblood pressure patterns

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the patterns with cognitive function and physicalfunctioning in CKD?. ### Response: 24-hour ambulatoryblood pressure patterns.


Instruction: What is the timing ofantihypertensive therapy to reduce nocturnal blood pressure?

Output: 8-week uncontrolled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the timing ofantihypertensive therapy to reduce nocturnal blood pressure?. ### Response: 8-week uncontrolled trial.


Instruction: What is the name of the journal published in 2007?

Output: Am J Kidney Dis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal published in 2007?. ### Response: Am J Kidney Dis.


Instruction: What are the ambulatory blood pressurephenotypes in adults taking antihypertensive medication with andwithout CKD?

Output: Mwasongwe SE, Tanner RM, Poudel B, et al. Ambulatory blood pressurephenotypes in adults taking antihypertensive medication with andwithout CKD. Clin J Am Soc Nephrol . 2020;15:501 –510.35

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the ambulatory blood pressurephenotypes in adults taking antihypertensive medication with andwithout CKD?. ### Response: Mwasongwe SE, Tanner RM, Poudel B, et al. Ambulatory blood pressurephenotypes in adults taking antihypertensive medication with andwithout CKD. Clin J Am Soc Nephrol . 2020;15:501 –510.35.


Instruction: When will the Clin J Am Soc Nephrol issue?

Output: 2020

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When will the Clin J Am Soc Nephrol issue?. ### Response: 2020.


Instruction: What is the name of the group that recommends screening for high blood pressure in adults?

Output: U.S. Preventive Services Task Force

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that recommends screening for high blood pressure in adults?. ### Response: U.S. Preventive Services Task Force.


Instruction: What are the names of the two groups that recommend the screening of high bloodpressure?

Output: Nasothimiou EG, Karpettas N, Dafni MG, et al. Patients ’preference forambulatory versus home

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the two groups that recommend the screening of high bloodpressure?. ### Response: Nasothimiou EG, Karpettas N, Dafni MG, et al. Patients ’preference forambulatory versus home.


Instruction: What is a worthy substitute for ambulatory blood pressure monitoring?

Output: Self blood pressure monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a worthy substitute for ambulatory blood pressure monitoring?. ### Response: Self blood pressure monitoring.


Instruction: What is the name of the study that compares theacceptability of and preferences for different methods of measuring blood pressure inprimary care?

Output: BMJ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that compares theacceptability of and preferences for different methods of measuring blood pressure inprimary care?. ### Response: BMJ.


Instruction: What is ambulatory blood pressure?

Output: 24-hour

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ambulatory blood pressure?. ### Response: 24-hour.


Instruction: What is the difference between home and clinic blood pressure monitoring?

Output: Disparate estimates ofhypertension control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between home and clinic blood pressure monitoring?. ### Response: Disparate estimates ofhypertension control.


Instruction: When did Beyhaghi H, Viera A, AJ, and Viera AJ compare cost-effectiveness of clinic, home, orambulatory pressure measurement?

Output: 2019

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Beyhaghi H, Viera A, AJ, and Viera AJ compare cost-effectiveness of clinic, home, orambulatory pressure measurement?. ### Response: 2019.


Instruction: What does pressure measurement for hypertension diagnosis in US adults do?

Output: Comparative cost-effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does pressure measurement for hypertension diagnosis in US adults do?. ### Response: Comparative cost-effectiveness.


Instruction: What is the name of the study that compares cost-effectiveness of options for the diagnosis of high blood pressure in primary care?

Output: Lancet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that compares cost-effectiveness of options for the diagnosis of high blood pressure in primary care?. ### Response: Lancet.


Instruction: What is a novel and simple protocol for the validation of home blood pressure monitors in clinical practice?

Output: Eguchi K

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a novel and simple protocol for the validation of home blood pressure monitors in clinical practice?. ### Response: Eguchi K.


Instruction: What are phar-macists a part of?

Output: health care team in ambulatory settings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are phar-macists a part of?. ### Response: health care team in ambulatory settings.


Instruction: What is a systematic review and meta-analysis of diabetes care?

Output: Impact of diabetes care by phar -macists as part of health care team in ambulatory settings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a systematic review and meta-analysis of diabetes care?. ### Response: Impact of diabetes care by phar -macists as part of health care team in ambulatory settings.


Instruction: What is the name of the systematic review and meta-analysis published in 2017?

Output: S2.1-4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta-analysis published in 2017?. ### Response: S2.1-4.


Instruction: What are the names of the authors of this systematic review?

Output: Fazel MT, Bagalagel A, Lee JK, et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the authors of this systematic review?. ### Response: Fazel MT, Bagalagel A, Lee JK, et al.


Instruction: What may be continued on ARBs if they subsequently develop HF?

Output: ARBs for other indications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be continued on ARBs if they subsequently develop HF?. ### Response: ARBs for other indications.


Instruction: What should be started at low doses and titrated upward with an attempt to use doses shown to reduce the risk of cardiovascular events in clinical trials?

Output: ARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be started at low doses and titrated upward with an attempt to use doses shown to reduce the risk of cardiovascular events in clinical trials?. ### Response: ARBs.


Instruction: What should be given with caution to patients with low systemic blood pressure, renal insufficiency, or elevated serum potassium?

Output: ARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be given with caution to patients with low systemic blood pressure, renal insufficiency, or elevated serum potassium?. ### Response: ARBs.


Instruction: What are alternatives for patients with ACE inhibitor-induced angioedema?

Output: ARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are alternatives for patients with ACE inhibitor-induced angioedema?. ### Response: ARBs.


Instruction: What does not exist for HF?

Output: Head-to-head comparisons of an ARB versus ARNI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not exist for HF?. ### Response: Head-to-head comparisons of an ARB versus ARNI.


Instruction: What remains advised for patients for whom an ACE inhibitor or ARNI is inappropriate?

Output: use of an ARB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What remains advised for patients for whom an ACE inhibitor or ARNI is inappropriate?. ### Response: use of an ARB.


Instruction: What is the name of the Eur opean Car otid Surgery Trial?

Output: ECST

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Eur opean Car otid Surgery Trial?. ### Response: ECST.


Instruction: What does ECST stand for?

Output: Eur opean Car otid Sur gery Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ECST stand for?. ### Response: Eur opean Car otid Sur gery Trial.


Instruction: Do not ha ve sur gery?

Output: • do not ha ve sur gery •

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Do not ha ve sur gery?. ### Response: • do not ha ve sur gery •.


Instruction: Contr ol of blood pr essur e, antiplat elet agent s, cholest erol lowering t hrough diet and drugs?

Output: Eur opean Car otid Sur gery Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Contr ol of blood pr essur e, antiplat elet agent s, cholest erol lowering t hrough diet and drugs?. ### Response: Eur opean Car otid Sur gery Trial.


Instruction: What is lowering t he extent of car otid st enosis used for?

Output: diet and drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is lowering t he extent of car otid st enosis used for?. ### Response: diet and drugs.


Instruction: What are specialist c are for pe ople?

Output: 1.3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are specialist c are for pe ople?. ### Response: 1.3.


Instruction: What is a st enosis?

Output: car otid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a st enosis?. ### Response: car otid.


Instruction: What are c are for pe ople wi th acu te str oke?

Output: Specialist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are c are for pe ople wi th acu te str oke?. ### Response: Specialist.


Instruction: How do you admit e veryone wit h suspect ed str oke to a specialist acut e stroke unit?

Output: directly

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do you admit e veryone wit h suspect ed str oke to a specialist acut e stroke unit?. ### Response: directly.


Instruction: What is an acut e stroke unit in t he hospital?

Output: a discr ete area

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an acut e stroke unit in t he hospital?. ### Response: a discr ete area.


Instruction: What is a specialist str oke multidisciplinar y team?

Output: An acut e stroke unit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a specialist str oke multidisciplinar y team?. ### Response: An acut e stroke unit.


Instruction: What type of team has access to equipment for monitoring and rehabilitating patient s?

Output: multidisciplinar y team

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of team has access to equipment for monitoring and rehabilitating patient s?. ### Response: multidisciplinar y team.


Instruction: When do regular multidisciplinar y team meetings occur f or goal setting?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When do regular multidisciplinar y team meetings occur f or goal setting?. ### Response: 2008.


Instruction: What are the assessmen t of people wi th suspe cted acute str oke?

Output: Brain imag ing f

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the assessmen t of people wi th suspe cted acute str oke?. ### Response: Brain imag ing f.


Instruction: What do people with suspected ed acut e stroke do?

Output: Perform brain imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do people with suspected ed acut e stroke do?. ### Response: Perform brain imaging.


Instruction: What is a non-enhanced CT f?

Output: people with suspect ed acut e stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a non-enhanced CT f?. ### Response: people with suspect ed acut e stroke.


Instruction: What are indications for thrombolysis or t hrombect omy?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are indications for thrombolysis or t hrombect omy?. ### Response: •.


Instruction: What is a depr essed le vel of consciousness?

Output: Glasgo w Coma Scor e belo w 13

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a depr essed le vel of consciousness?. ### Response: Glasgo w Coma Scor e belo w 13.


Instruction: What is Stroke and transient ischaemic attack in o ver 16s: diagnosis and initial management(NG128)?

Output: unexplained pr ogressiv e or fluctuating sympt oms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Stroke and transient ischaemic attack in o ver 16s: diagnosis and initial management(NG128)?. ### Response: unexplained pr ogressiv e or fluctuating sympt oms.


Instruction: What is the last updat ed 13 April 2022?

Output: Page 9of 48

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the last updat ed 13 April 2022?. ### Response: Page 9of 48.


Instruction: What is a pproach to care?

Output: Chronic Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a pproach to care?. ### Response: Chronic Heart Failure.


Instruction: What may patients not want to know about their prognosis?

Output: everything

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may patients not want to know about their prognosis?. ### Response: everything.


Instruction: What might be suggested as a way of coping?

Output: paternalism or recognition of denial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What might be suggested as a way of coping?. ### Response: paternalism or recognition of denial.


Instruction: What did some feel it was more appropriate to address?

Output: prognosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did some feel it was more appropriate to address?. ### Response: prognosis.


Instruction: What might be approaching the end of a patient's life?

Output: Chronic Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What might be approaching the end of a patient's life?. ### Response: Chronic Heart Failure.


Instruction: What did a common professional perception of this type of exchange between clinician and patient not happen often enough?

Output: prognosis was rarely discussed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a common professional perception of this type of exchange between clinician and patient not happen often enough?. ### Response: prognosis was rarely discussed.


Instruction: In one study, cardiac staff confirmed issues such as future care in the event of what?

Output: an exacerbation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In one study, cardiac staff confirmed issues such as future care in the event of what?. ### Response: an exacerbation.


Instruction: How are future care in the event of an exacerbation or end-of-life preferences rarely raised with patients?

Output: issues

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are future care in the event of an exacerbation or end-of-life preferences rarely raised with patients?. ### Response: issues.


Instruction: What was suggested that lessons could be learned from?

Output: communication in cancer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was suggested that lessons could be learned from?. ### Response: communication in cancer.


Instruction: How many studies were used in this study?

Output: six

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were used in this study?. ### Response: six.


Instruction: What did cardiac staff report having difficulties with?

Output: patient denial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did cardiac staff report having difficulties with?. ### Response: patient denial.


Instruction: How many studies were based on this subfinding?

Output: six

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were based on this subfinding?. ### Response: six.


Instruction: What were methodological limitations rated as?

Output: ser ious

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were methodological limitations rated as?. ### Response: ser ious.


Instruction: How were three studies rated moderate limitations?

Output: due to the lack of the role of the researcher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How were three studies rated moderate limitations?. ### Response: due to the lack of the role of the researcher.


Instruction: How many studies were rated serious limitations?

Output: Two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were rated serious limitations?. ### Response: Two.


Instruction: What was one of the limitations of the two studies?

Output: limited information on the background and reflection of the researcher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was one of the limitations of the two studies?. ### Response: limited information on the background and reflection of the researcher.


Instruction: What was one study rated as lacking reflection on the researc her role in the study, limited context, reasoning for the choice of methods and richness of data?

Output: moderate limitations due to the lack of the role of the researcher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was one study rated as lacking reflection on the researc her role in the study, limited context, reasoning for the choice of methods and richness of data?. ### Response: moderate limitations due to the lack of the role of the researcher.


Instruction: What was one study rated as having very serious limitations due to the limited information on the background and reflection of the researcher?

Output: data collection, dat a richness, relevance of findings and a link to conclusions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was one study rated as having very serious limitations due to the limited information on the background and reflection of the researcher?. ### Response: data collection, dat a richness, relevance of findings and a link to conclusions.


Instruction: What was rated no or very minor concerns overall?

Output: Coherence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was rated no or very minor concerns overall?. ### Response: Coherence.


Instruction: How many studies did the data stem from?

Output: six

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies did the data stem from?. ### Response: six.


Instruction: What was the relevance of the subfinding to the focus of the review very high?

Output: The data stemmed from six studies from the UK in a relevant population

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the relevance of the subfinding to the focus of the review very high?. ### Response: The data stemmed from six studies from the UK in a relevant population.


Instruction: How many studies did the data come from?

Output: six

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies did the data come from?. ### Response: six.


Instruction: What was the overall assessment of confidence?

Output: moderate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the overall assessment of confidence?. ### Response: moderate.


Instruction: Why was the confidence rating downgraded?

Output: methodological limitations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the confidence rating downgraded?. ### Response: methodological limitations.


Instruction: Why was prognosis downgraded by one increment?

Output: methodological limitations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was prognosis downgraded by one increment?. ### Response: methodological limitations.


Instruction: What did some patients report?

Output: prognosis was rarely discussed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did some patients report?. ### Response: prognosis was rarely discussed.


Instruction: What did Hindricks G, Willems S, Kautzner J, et al. do on fluoroscopy time and resource use?

Output: Effect of electroanatomically guided versus conventional catheter ablation of typical atrial flutter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Hindricks G, Willems S, Kautzner J, et al. do on fluoroscopy time and resource use?. ### Response: Effect of electroanatomically guided versus conventional catheter ablation of typical atrial flutter.


Instruction: What was the effect of electroanatomically guided versus conventional catheter ablation of typical atrial flutter on?

Output: fluoroscopy time and resource use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the effect of electroanatomically guided versus conventional catheter ablation of typical atrial flutter on?. ### Response: fluoroscopy time and resource use.


Instruction: What does the use of an integrated electro-anatomic mapping system and intracardiac echocardiography reduce radiation exposure in children and young adults undergoing ablation of supraventricular tachycardia?

Output: reduce radiation exposure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the use of an integrated electro-anatomic mapping system and intracardiac echocardiography reduce radiation exposure in children and young adults undergoing ablation of supraventricular tachycardia?. ### Response: reduce radiation exposure.


Instruction: What does Europace. 2014;16:277–83?

Output: tachycardia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Europace. 2014;16:277–83?. ### Response: tachycardia.


Instruction: What is the name of the system used for supraventricular arrhythmia ablation?

Output: EnSite NavX™

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the system used for supraventricular arrhythmia ablation?. ### Response: EnSite NavX™.


Instruction: What does the EnSite NavXTM mapping system do?

Output: personal experience and review of the literature

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the EnSite NavXTM mapping system do?. ### Response: personal experience and review of the literature.


Instruction: What is the NavXTM mapping system?

Output: EnSite

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the NavXTM mapping system?. ### Response: EnSite.


Instruction: When did the J Interv Card Electrophysiol. 2011:31:109–18?

Output: 151

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the J Interv Card Electrophysiol. 2011:31:109–18?. ### Response: 151.


Instruction: What is nonfluoroscopic cath-eter ablation in adults: feasibility, safety, and ef-ficacy?

Output: cardiac arrhythmias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is nonfluoroscopic cath-eter ablation in adults: feasibility, safety, and ef-ficacy?. ### Response: cardiac arrhythmias.


Instruction: What is a potential randomized trial of radiofrequency ablation of arrhythmias guided by?

Output: non-fluoroscopic catheter location

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a potential randomized trial of radiofrequency ablation of arrhythmias guided by?. ### Response: non-fluoroscopic catheter location.


Instruction: What is an initial clinical experience of remote magnetic navigation system for catheter mapping and ablation?

Output: personal experience and review of the literature

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an initial clinical experience of remote magnetic navigation system for catheter mapping and ablation?. ### Response: personal experience and review of the literature.


Instruction: What is used for catheter mapping and ablation of supraventricular tachycardias?

Output: remote magnetic navigation system

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used for catheter mapping and ablation of supraventricular tachycardias?. ### Response: remote magnetic navigation system.


Instruction: When did J Interv Card Electrophysiol. 2009:25:171–4?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J Interv Card Electrophysiol. 2009:25:171–4?. ### Response: 2009.


Instruction: What is the name of the device used to ablate typical atrial flutter?

Output: three-dimensional catheter tracking system

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the device used to ablate typical atrial flutter?. ### Response: three-dimensional catheter tracking system.


Instruction: What does Europace call alternative energy sources for the ablation of arrhythmias?

Output: 155

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Europace call alternative energy sources for the ablation of arrhythmias?. ### Response: 155.


Instruction: What is the name of the meta-analysis and systematic review of cryoablation versus RF ablation for A VNRT?

Output: Hanninen M, Yeung-Lai-Wah N, Massel D, et al. Cryoablation versus RF ablation for A VNRT: a meta-analysis and systematic review. J Cardiovasc Electrophysiol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis and systematic review of cryoablation versus RF ablation for A VNRT?. ### Response: Hanninen M, Yeung-Lai-Wah N, Massel D, et al. Cryoablation versus RF ablation for A VNRT: a meta-analysis and systematic review. J Cardiovasc Electrophysiol.


Instruction: What is the name of the multicenter prospective "frosty" trial?

Output: Catheter cryoablation of su-praventricular tachycardia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multicenter prospective "frosty" trial?. ### Response: Catheter cryoablation of su-praventricular tachycardia.


Instruction: What is a common complication of su-praventricular tachycardia?

Output: radiation exposure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a common complication of su-praventricular tachycardia?. ### Response: radiation exposure.


Instruction: What is the difference between cryoablation and radiofrequency ablation for the treatment of atrioventricular nodal reentrant tachycardia?

Output: fluoro-scopic guidance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between cryoablation and radiofrequency ablation for the treatment of atrioventricular nodal reentrant tachycardia?. ### Response: fluoro-scopic guidance.


Instruction: What did Eckhardt LLL, Leal M, Hollis Z, et al. do for A VNRT: im-portance of ablation endpoint criteria?

Output: Cryoablation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Eckhardt LLL, Leal M, Hollis Z, et al. do for A VNRT: im-portance of ablation endpoint criteria?. ### Response: Cryoablation.


Instruction: What is the ablation endpoint criteria?

Output: Cryoablation for A VNRT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ablation endpoint criteria?. ### Response: Cryoablation for A VNRT.


Instruction: What is a child's heart rate in children and adults?

Output: Intrinsic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a child's heart rate in children and adults?. ### Response: Intrinsic.


Instruction: What do we suggest for patients who present with a clinicaldocumented episode of AF?

Output: that the presence or absence ofsymptoms must not in ﬂuence the process of decision-making

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do we suggest for patients who present with a clinicaldocumented episode of AF?. ### Response: that the presence or absence ofsymptoms must not in ﬂuence the process of decision-making.


Instruction: What is the need for anticoagulationbased on?

Output: risk strati ﬁcation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the need for anticoagulationbased on?. ### Response: risk strati ﬁcation.


Instruction: What is AHRE?

Output: atrial high-rate episodes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is AHRE?. ### Response: atrial high-rate episodes.


Instruction: How long does a CIED of at least 5 min duration last?

Output: 41

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does a CIED of at least 5 min duration last?. ### Response: 41.


Instruction: What is AF?

Output: symptomatic orasymptomatic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is AF?. ### Response: symptomatic orasymptomatic.


Instruction: What is indicated in patients with CIED-detected AHRE?

Output: continued patient follow-up

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is indicated in patients with CIED-detected AHRE?. ### Response: continued patient follow-up.


Instruction: How is a complete cardiological evaluation indicated?

Output: Ungraded consensus-based statement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is a complete cardiological evaluation indicated?. ### Response: Ungraded consensus-based statement.


Instruction: What is there no evidence in support of or against prescribing oral anticoagulants in patients at risk of stroke?

Output: Remark : There is no evidence in support or againstprescription of oral anticoagulants in patients at risk ofstroke (intermediate to high risk according toCHA 2DS2-VASc) who present with AHREs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is there no evidence in support of or against prescribing oral anticoagulants in patients at risk of stroke?. ### Response: Remark : There is no evidence in support or againstprescription of oral anticoagulants in patients at risk ofstroke (intermediate to high risk according toCHA 2DS2-VASc) who present with AHREs.


Instruction: What are patients with AHREs corresponding to?

Output: CIED-detected

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients with AHREs corresponding to?. ### Response: CIED-detected.


Instruction: What could be considered for patients with AF?

Output: prescription oforal anticoagulants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could be considered for patients with AF?. ### Response: prescription oforal anticoagulants.


Instruction: What should be taken into account in the individualized clinical assessment?

Output: overall AHRE burden

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be taken into account in the individualized clinical assessment?. ### Response: overall AHRE burden.


Instruction: How long does AHRE burden last?

Output: hoursrather than minutes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does AHRE burden last?. ### Response: hoursrather than minutes.


Instruction: What is CHA2DS2-VASc?

Output: intermediate to high risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CHA2DS2-VASc?. ### Response: intermediate to high risk.


Instruction: What is Ungradedconsensus-based statement?

Output: oral anticoagulationand informed patient preferences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Ungradedconsensus-based statement?. ### Response: oral anticoagulationand informed patient preferences.


Instruction: In patients with CIED-detected AHRE,continued patient follow-up is recommended?

Output: acomplete cardiological evaluation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with CIED-detected AHRE,continued patient follow-up is recommended?. ### Response: acomplete cardiological evaluation.


Instruction: What is clinical AF?

Output: symptomatic orasymptomatic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is clinical AF?. ### Response: symptomatic orasymptomatic.


Instruction: What is asymptomatic?

Output: clinical AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is asymptomatic?. ### Response: clinical AF.


Instruction: How long does AHRE last?

Output: more than 24 h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does AHRE last?. ### Response: more than 24 h.


Instruction: What do we suggest for patients with atrial flutter?

Output: antithrombotic therapy decisions follow the samerisk-based recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do we suggest for patients with atrial flutter?. ### Response: antithrombotic therapy decisions follow the samerisk-based recommendations.


Instruction: What are the samerisk-based recommendations as for AF?

Output: Ungradedconsensus-based statement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the samerisk-based recommendations as for AF?. ### Response: Ungradedconsensus-based statement.


Instruction: For women receiving OAC for prevention of stroke/TE in AF who become pregnant, we suggest discontinuation of OAC with what?

Output: a VKA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For women receiving OAC for prevention of stroke/TE in AF who become pregnant, we suggest discontinuation of OAC with what?. ### Response: a VKA.


Instruction: What do we suggest discontinuing OAC with between weeks 6 and 12?

Output: VKA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do we suggest discontinuing OAC with between weeks 6 and 12?. ### Response: VKA.


Instruction: How often do we recommend LMWH twice daily?

Output: 24 h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often do we recommend LMWH twice daily?. ### Response: 24 h.


Instruction: What is the recommended dose of warfarin?

Output: >5 mg/day

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommended dose of warfarin?. ### Response: >5 mg/day.


Instruction: What is the target anti-Xa level4-6 h post-dose 0.8-1.2 U/mL in the 36th week ofgestation?

Output: adjusted-dose LMWH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the target anti-Xa level4-6 h post-dose 0.8-1.2 U/mL in the 36th week ofgestation?. ### Response: adjusted-dose LMWH.


Instruction: What should OAC be discontinued and replaced by?

Output: adjusted-dose LMWH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should OAC be discontinued and replaced by?. ### Response: adjusted-dose LMWH.


Instruction: What is the 2018 ACHD GuidelineCirculation. 2019;139:e698–e800?

Output: Stout et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2018 ACHD GuidelineCirculation. 2019;139:e698–e800?. ### Response: Stout et al.


Instruction: What should patients with ACHD be evaluated for?

Output: depression and anxiety

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients with ACHD be evaluated for?. ### Response: depression and anxiety.


Instruction: Who should be evaluated for depression and anxiety?

Output: Patients with ACHD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should be evaluated for depression and anxiety?. ### Response: Patients with ACHD.


Instruction: What is reasonable in patients with ACHD?

Output: Referral for mental health evaluation and treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable in patients with ACHD?. ### Response: Referral for mental health evaluation and treatment.


Instruction: Neurodevelopmental or neuropsychological testing may be considered in some patients with what?

Output: ACHD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Neurodevelopmental or neuropsychological testing may be considered in some patients with what?. ### Response: ACHD.


Instruction: What does ACHD do to guide therapies that enhance academic, behavioral, psychosocial, and adaptive functioning?

Output: Neurodevelopmental or neuropsychological testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ACHD do to guide therapies that enhance academic, behavioral, psychosocial, and adaptive functioning?. ### Response: Neurodevelopmental or neuropsychological testing.


Instruction: What are com-mon in patients with ACHD and may significantly affect QoL?

Output: Mental health and neurodevelopmental issues

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are com-mon in patients with ACHD and may significantly affect QoL?. ### Response: Mental health and neurodevelopmental issues.


Instruction: Neurodevelopmental abnormalities are more frequently seen in children who have complex disease and what other characteristics?

Output: com-plex surgical repairs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Neurodevelopmental abnormalities are more frequently seen in children who have complex disease and what other characteristics?. ### Response: com-plex surgical repairs.


Instruction: What are some of the characteristics of neurodevelopmental disorders?

Output: impairment of cognition, social skills and communication, and attention disorders

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the characteristics of neurodevelopmental disorders?. ### Response: impairment of cognition, social skills and communication, and attention disorders.


Instruction: What is extensive literature in the pediatric population on the frequency and importance of?

Output: neurodevelopmen-tal abnormalities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is extensive literature in the pediatric population on the frequency and importance of?. ### Response: neurodevelopmen-tal abnormalities.


Instruction: What are neurode-velopmental disorders often under-recognized?

Output: impairment of cognition, social skills and communication, and attention disorders

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are neurode-velopmental disorders often under-recognized?. ### Response: impairment of cognition, social skills and communication, and attention disorders.


Instruction: What may be beneficial in optimizing function and QoL?

Output: rehabilitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be beneficial in optimizing function and QoL?. ### Response: rehabilitation.


Instruction: An AHA scientific state-ment describes the common neurodevelopmental disor-ders affecting children with what type of disorder?

Output: CHD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: An AHA scientific state-ment describes the common neurodevelopmental disor-ders affecting children with what type of disorder?. ### Response: CHD.


Instruction: What is underrecognized in the ACHD population?

Output: Anxiety and depression

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is underrecognized in the ACHD population?. ### Response: Anxiety and depression.


Instruction: What should be included in the symptom review?

Output: Point-of-care assessment with simple questions about anxiety and depres-sion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be included in the symptom review?. ### Response: Point-of-care assessment with simple questions about anxiety and depres-sion.


Instruction: Anxiety and depression are prevalent among patients with what condition?

Output: ACHD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Anxiety and depression are prevalent among patients with what condition?. ### Response: ACHD.


Instruction: Self-reported symptoms are incomplete to identify the existence of what?

Output: mood disorders

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Self-reported symptoms are incomplete to identify the existence of what?. ### Response: mood disorders.


Instruction: Structured professional psychological evaluation can identify up to how much more patients with mood disorders?

Output: 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Structured professional psychological evaluation can identify up to how much more patients with mood disorders?. ### Response: 50%.


Instruction: What is there limited evidence on in patients with ACHD?

Output: neuro-developmental and neuropsychological issues

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is there limited evidence on in patients with ACHD?. ### Response: neuro-developmental and neuropsychological issues.


Instruction: What is increasing evi-dence of the neurodevelopmental impact of CHD and surgery in childhood?

Output: Although there is limited evidence on neuro-developmental and neuropsychological issues in patients with ACHD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is increasing evi-dence of the neurodevelopmental impact of CHD and surgery in childhood?. ### Response: Although there is limited evidence on neuro-developmental and neuropsychological issues in patients with ACHD.


Instruction: What genetic condition is particularly evident in patients with 22q11 deletion and trisomy 21.3.8?

Output: Endocarditis Prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What genetic condition is particularly evident in patients with 22q11 deletion and trisomy 21.3.8?. ### Response: Endocarditis Prevention.


Instruction: Patients with ACHD have an increased risk of developing what type of endocarditis?

Output: infective

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with ACHD have an increased risk of developing what type of endocarditis?. ### Response: infective.


Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al.


Instruction: What is the name of the guideline that will be published in 2021?

Output: ACC/AHA Guideline for the Management of Valvular Heart DiseaseCirculation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the guideline that will be published in 2021?. ### Response: ACC/AHA Guideline for the Management of Valvular Heart DiseaseCirculation.


Instruction: How old are patients who received a bioprosthetic vs mechanical mitral valve replacement?

Output: 50 to 69 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old are patients who received a bioprosthetic vs mechanical mitral valve replacement?. ### Response: 50 to 69 years.


Instruction: What is the age range of mechanical mitral valve replacement in patients?

Output: <65 years old

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the age range of mechanical mitral valve replacement in patients?. ### Response: <65 years old.


Instruction: When did the JAMA publish 313:1435-42?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the JAMA publish 313:1435-42?. ### Response: 2015.


Instruction: What did McClure RS, McGurk S, Cevasco M, et al. do?

Output: Late outcomes comparison of nonelderly patients with stented bioprosthetic and mechanical valves in the aortic position: a propensity-matched analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did McClure RS, McGurk S, Cevasco M, et al. do?. ### Response: Late outcomes comparison of nonelderly patients with stented bioprosthetic and mechanical valves in the aortic position: a propensity-matched analysis.


Instruction: What is the name of the study that examined survival and long-term out-comes following bioprosthetic vs mechanical aortic valve replacement in patients aged 50 to 69 years?

Output: JAMA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined survival and long-term out-comes following bioprosthetic vs mechanical aortic valve replacement in patients aged 50 to 69 years?. ### Response: JAMA.


Instruction: What year did JAMA issue 312:1323-9.

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did JAMA issue 312:1323-9.. ### Response: 2014.


Instruction: How old is the median age for mitral valve replacement?

Output: <65

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old is the median age for mitral valve replacement?. ### Response: <65.


Instruction: What is the average age for mechanical versus bioprosthetic valve replacement in patients 65 years old?

Output: <65

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the average age for mechanical versus bioprosthetic valve replacement in patients 65 years old?. ### Response: <65.


Instruction: When was the J Thorac Cardiovasc Surg. 2014:147:117–26?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Thorac Cardiovasc Surg. 2014:147:117–26?. ### Response: 2004.


Instruction: How long did the Ross procedure last?

Output: 25-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the Ross procedure last?. ### Response: 25-year.


Instruction: What is the name of the randomised controlled trial of autograft and homograft aortic root replacement?

Output: Lancet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised controlled trial of autograft and homograft aortic root replacement?. ### Response: Lancet.


Instruction: What are the results of the randomized controlled trial?

Output: Long-term outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of the randomized controlled trial?. ### Response: Long-term outcomes.


Instruction: Who is the author of the study?

Output: Otto

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of the study?. ### Response: Otto.


Instruction: How many implantations did the Carpentier-Edwards pericardial bio-prosthesis have?

Output: 450

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many implantations did the Carpentier-Edwards pericardial bio-prosthesis have?. ### Response: 450.


Instruction: What was the follow-up period of the carpenter-edward's aortic valve?

Output: 25-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the follow-up period of the carpenter-edward's aortic valve?. ### Response: 25-year.


Instruction: What year did Ann Thorac Surg publish 100:853-9?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Ann Thorac Surg publish 100:853-9?. ### Response: 2015.


Instruction: What is the STS/ACC reg-istry?

Output: Transcatheter aortic valve re-placement of failed surgically implanted bioprostheses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the STS/ACC reg-istry?. ### Response: Transcatheter aortic valve re-placement of failed surgically implanted bioprostheses.


Instruction: How long did it take to implant aortic and mitral valves for failed surgical bioprosthetic valves?

Output: 8-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take to implant aortic and mitral valves for failed surgical bioprosthetic valves?. ### Response: 8-year.


Instruction: What is the JACC Cardiovasc Interv. 2015;8:1735–44?

Output: Transcatheter aortic and mitral valve-in-valve implantation for failed surgical bioprosthetic valves: an 8-year single-center experience

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the JACC Cardiovasc Interv. 2015;8:1735–44?. ### Response: Transcatheter aortic and mitral valve-in-valve implantation for failed surgical bioprosthetic valves: an 8-year single-center experience.


Instruction: How long was it for a single center to implantation a transcatheter valve in a surgical valve?

Output: 8-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was it for a single center to implantation a transcatheter valve in a surgical valve?. ### Response: 8-year.


Instruction: What is the name of the registry that provides results for transcatheter aortic valve replacement for degenerative bioprosthetic surgical valves?

Output: global valve-in-valve registry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the registry that provides results for transcatheter aortic valve replacement for degenerative bioprosthetic surgical valves?. ### Response: global valve-in-valve registry.


Instruction: What is TAVR in low-risk patients: FDA approval, the new NCD and shared decision-making?

Output: FDA approval

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is TAVR in low-risk patients: FDA approval, the new NCD and shared decision-making?. ### Response: FDA approval.


Instruction: What is new NCD?

Output: FDA approval

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is new NCD?. ### Response: FDA approval.


Instruction: What is shared decision-making?

Output: TAVR in low-risk patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is shared decision-making?. ### Response: TAVR in low-risk patients.


Instruction: J Am Coll Car-diol. 2020;75:1208–11.

Output: ortic valve implantation in failed bioprosthetic surgical valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: J Am Coll Car-diol. 2020;75:1208–11.. ### Response: ortic valve implantation in failed bioprosthetic surgical valves.


Instruction: What was the baseline SBP of stroke at high risk for?

Output: cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the baseline SBP of stroke at high risk for?. ### Response: cardiovascular disease.


Instruction: What reduced fatal and nonfatal cardiovascular events andall-cause mortality?

Output: stroke, at high-risk for cardiovascular disease, and witha baseline SBP of less than 140 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What reduced fatal and nonfatal cardiovascular events andall-cause mortality?. ### Response: stroke, at high-risk for cardiovascular disease, and witha baseline SBP of less than 140 mm Hg.


Instruction: How many adults were included in ACCORD?

Output: 40

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many adults were included in ACCORD?. ### Response: 40.


Instruction: What was the primary composite outcome of the study?

Output: RR, 0.94 [CI, 0.80 to 1.11]).

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary composite outcome of the study?. ### Response: RR, 0.94 [CI, 0.80 to 1.11])..


Instruction: What is the RR?

Output: 0.58

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the RR?. ### Response: 0.58.


Instruction: How was the reduction in stroke events found?

Output: pooled estimates from all stud-ies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the reduction in stroke events found?. ### Response: pooled estimates from all stud-ies.


Instruction: What is the SBP target of less than 120 mm Hg versus less than 140 mmHg?

Output: stroke events (RR, 0.58 [CI, 0.39 to 0.88]),but there were more serious adverse events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the SBP target of less than 120 mm Hg versus less than 140 mmHg?. ### Response: stroke events (RR, 0.58 [CI, 0.39 to 0.88]),but there were more serious adverse events.


Instruction: What is low quality evidence of?

Output: no statistically signiﬁcant reduction in mortality, cardiacevents, or stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is low quality evidence of?. ### Response: no statistically signiﬁcant reduction in mortality, cardiacevents, or stroke.


Instruction: What is an individualized assessment impor-tant to evaluate the benefit of lower blood pressuretargets relative to harms in patients age 60 years and older?

Output: beneﬁ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an individualized assessment impor-tant to evaluate the benefit of lower blood pressuretargets relative to harms in patients age 60 years and older?. ### Response: beneﬁ.


Instruction: What are the AREAS OF INCONCLUSIVE EVIDENCE?

Output: reatment of Patients With Multiple ChronicConditions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the AREAS OF INCONCLUSIVE EVIDENCE?. ### Response: reatment of Patients With Multiple ChronicConditions.


Instruction: What did no trials assess the relationship between multi-ple comorbid conditions and the benefits and harms oftreating BP to different targets?

Output: AREAS OF INCONCLUSIVE EVIDENCETreatment of Patients With Multiple ChronicConditions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did no trials assess the relationship between multi-ple comorbid conditions and the benefits and harms oftreating BP to different targets?. ### Response: AREAS OF INCONCLUSIVE EVIDENCETreatment of Patients With Multiple ChronicConditions.


Instruction: Patients with a high co-morbidity burden were probably not included in theoverall group of studies?

Output: No trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with a high co-morbidity burden were probably not included in theoverall group of studies?. ### Response: No trials.


Instruction: What was insufficient for targeting treatmentaccording to DBP?

Output: 120 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was insufficient for targeting treatmentaccording to DBP?. ### Response: 120 mm Hg.


Instruction: What was excluded from most studies?

Output: patients who haddementia or diminished functional status

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was excluded from most studies?. ### Response: patients who haddementia or diminished functional status.


Instruction: What was insufficient for targeting treatment according to DBP?

Output: 120 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was insufficient for targeting treatment according to DBP?. ### Response: 120 mm Hg.


Instruction: What is par-ticularly important in adults aged 60 years or older with multiple chronic conditions?

Output: Individual assessment of beneﬁts and harms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is par-ticularly important in adults aged 60 years or older with multiple chronic conditions?. ### Response: Individual assessment of beneﬁts and harms.


Instruction: Why might patients theoretically benefit from more aggressive BP treatment?

Output: higher car-diovascular risks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why might patients theoretically benefit from more aggressive BP treatment?. ### Response: higher car-diovascular risks.


Instruction: Why are people more likely to besusceptible to serious harm from higher rates of syn-cope and hypotension?

Output: higher car-diovascular risks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why are people more likely to besusceptible to serious harm from higher rates of syn-cope and hypotension?. ### Response: higher car-diovascular risks.


Instruction: Are absolute benefits of more aggressive BPtreatment in elderly persons, those with multimorbidity or those who are frail?

Output: not well-known

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Are absolute benefits of more aggressive BPtreatment in elderly persons, those with multimorbidity or those who are frail?. ### Response: not well-known.


Instruction: Who are not well-known?

Output: elderly persons, those with multimorbidity,or those who are frail

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who are not well-known?. ### Response: elderly persons, those with multimorbidity,or those who are frail.


Instruction: What are elderly persons, those with multimorbidity, or those who are frail?

Output: more aggressive BPtreatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are elderly persons, those with multimorbidity, or those who are frail?. ### Response: more aggressive BPtreatment.


Instruction: What type of criteria did most trials have that excluded patients with haddementia or diminished functional status?

Output: implicitly or explicitly

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of criteria did most trials have that excluded patients with haddementia or diminished functional status?. ### Response: implicitly or explicitly.


Instruction: How many trials had exclusion criteria?

Output: Few trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many trials had exclusion criteria?. ### Response: Few trials.


Instruction: What type of complications does QOL avoid?

Output: vascular

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of complications does QOL avoid?. ### Response: vascular.


Instruction: What is the risk of permanent pacer?

Output: Higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of permanent pacer?. ### Response: Higher.


Instruction: How long does it take to recover from a stroke?

Output: longer hospital stay, pain in recovery period

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take to recover from a stroke?. ### Response: longer hospital stay, pain in recovery period.


Instruction: What is the balance between expected patient longevity and valve durability?

Output: varies continuously across the age range

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the balance between expected patient longevity and valve durability?. ### Response: varies continuously across the age range.


Instruction: What are more durable valves preferred for patients with stroke?

Output: mechanical valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are more durable valves preferred for patients with stroke?. ### Response: mechanical valves.


Instruction: What are more durable valves preferred for patients with a longer life expectancy?

Output: mechanical valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are more durable valves preferred for patients with a longer life expectancy?. ### Response: mechanical valves.


Instruction: What is finite (with shorter durability for younger patients)?

Output: Bioprosthetic valve durability

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is finite (with shorter durability for younger patients)?. ### Response: Bioprosthetic valve durability.


Instruction: Mechanical valves are very durable but require what type of anticoagulation?

Output: lifelong

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Mechanical valves are very durable but require what type of anticoagulation?. ### Response: lifelong.


Instruction: How long are data on outcomes with surgical bioprosthetic valves available?

Output: 20-y

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long are data on outcomes with surgical bioprosthetic valves available?. ### Response: 20-y.


Instruction: How long do transcatheter bioprosthetic valves last?

Output: 5 y

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long do transcatheter bioprosthetic valves last?. ### Response: 5 y.


Instruction: What should be individualized on the basis of?

Output: patient-specific factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be individualized on the basis of?. ### Response: patient-specific factors.


Instruction: A large aortic annulus may not be suitable for what?

Output: currently available transcatheter valve sizes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A large aortic annulus may not be suitable for what?. ### Response: currently available transcatheter valve sizes.


Instruction: What may not be suitable for currently available transcatheter valve sizes?

Output: A large aortic annulus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may not be suitable for currently available transcatheter valve sizes?. ### Response: A large aortic annulus.


Instruction: What may be needed to allow placement of a larger prosthesis and avoid patient-prosthesis mismatch?

Output: a surgical annulus-enlarging procedure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be needed to allow placement of a larger prosthesis and avoid patient-prosthesis mismatch?. ### Response: a surgical annulus-enlarging procedure.


Instruction: What indicates atrial fibrillation?

Output: AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates atrial fibrillation?. ### Response: AF.


Instruction: What indicates aortic stenosis?

Output: AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates aortic stenosis?. ### Response: AF.


Instruction: BAV stands for what?

Output: bicuspid aortic valve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: BAV stands for what?. ### Response: bicuspid aortic valve.


Instruction: What is SAVR?

Output: surgical aortic valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SAVR?. ### Response: surgical aortic valve replacement.


Instruction: What is TAVI?

Output: transcatheter aortic valve implantation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is TAVI?. ### Response: transcatheter aortic valve implantation.


Instruction: What is the difference between direct oral anticoagulants and vitamin K antagonists foracute venous thromboembolism?

Output: Effectiveness and safety

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between direct oral anticoagulants and vitamin K antagonists foracute venous thromboembolism?. ### Response: Effectiveness and safety.


Instruction: What does Valkhoff VE, Kuipers EJ, Tjwa ET, and Holster IL do to increase risk for gastrointestinal bleeding?

Output: New oralanticoagulants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Valkhoff VE, Kuipers EJ, Tjwa ET, and Holster IL do to increase risk for gastrointestinal bleeding?. ### Response: New oralanticoagulants.


Instruction: What is a systematic review and meta-analysis of anticoagulants for gastrointestinal bleeding?

Output: asystematic review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a systematic review and meta-analysis of anticoagulants for gastrointestinal bleeding?. ### Response: asystematic review.


Instruction: What is the name of the systematic review that focuses on direct oral anticoagulant in the treatment of acute venous thromboembolism?

Output: meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review that focuses on direct oral anticoagulant in the treatment of acute venous thromboembolism?. ### Response: meta-analysis.


Instruction: What is the name of the study that evaluated the efficacy and safety of novel oral anticoagulants for treatment of acutevenous thromboembolism?

Output: phase 3 trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated the efficacy and safety of novel oral anticoagulants for treatment of acutevenous thromboembolism?. ### Response: phase 3 trials.


Instruction: What is a direct and adjusted indirect meta-analysis of randomised controlled trials?

Output: embolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a direct and adjusted indirect meta-analysis of randomised controlled trials?. ### Response: embolism.


Instruction: When did BMJ issue 345:e7498?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did BMJ issue 345:e7498?. ### Response: 2012.


Instruction: What does Klok FA,Huisman MV compare to vitamin K antagonists in the treatment of acutesymptomatic venous thromboembolism?

Output: Direct oral anticoagulants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Klok FA,Huisman MV compare to vitamin K antagonists in the treatment of acutesymptomatic venous thromboembolism?. ### Response: Direct oral anticoagulants.


Instruction: What is a direct comparison of dabigatran, rivaroxaban,apixaban and edoxaban?

Output: vitamin K antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a direct comparison of dabigatran, rivaroxaban,apixaban and edoxaban?. ### Response: vitamin K antagonists.


Instruction: What drug is used for the treatment of acute venousthromboembolism?

Output: vitamin K antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug is used for the treatment of acute venousthromboembolism?. ### Response: vitamin K antagonists.


Instruction: What is the name of the systematic review and meta-analysis of the impact of bleeding complications in patients receiving target-speci fic oralanticoagulants?

Output: asystematic review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta-analysis of the impact of bleeding complications in patients receiving target-speci fic oralanticoagulants?. ### Response: asystematic review.


Instruction: What is the case-fatality of recurrent venous thromboembolism and major bleeding associated with?

Output: aspirin, warfarin, and direct oral anticoagulants forsecondary prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the case-fatality of recurrent venous thromboembolism and major bleeding associated with?. ### Response: aspirin, warfarin, and direct oral anticoagulants forsecondary prevention.


Instruction: What are aspirin, warfarin, and direct oral anticoagulants forsecondary prevention?

Output: Case-fatality of recurrent venous thromboembolism and major bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are aspirin, warfarin, and direct oral anticoagulants forsecondary prevention?. ### Response: Case-fatality of recurrent venous thromboembolism and major bleeding.


Instruction: When did Thromb Res 2015 issue 135(2):243-248?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Thromb Res 2015 issue 135(2):243-248?. ### Response: 2015.


Instruction: What is the name of the systematic review and meta-analysis of outcomes associated with treatment of acute venousthromboembolism?

Output: Direct oral anticoagulants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta-analysis of outcomes associated with treatment of acute venousthromboembolism?. ### Response: Direct oral anticoagulants.


Instruction: Which journal published a review of the safety and efficacy of anticoagulant therapy for thetreatment of acute cancer-associatedthrombosis?

Output: JAMA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which journal published a review of the safety and efficacy of anticoagulant therapy for thetreatment of acute cancer-associatedthrombosis?. ### Response: JAMA.


Instruction: What is a systematic review and meta-analysis of oral anticoagulants in patients with vte and cancer?

Output: Chest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a systematic review and meta-analysis of oral anticoagulants in patients with vte and cancer?. ### Response: Chest.


Instruction: What is the ef ficacy and safety of new oralanticoagulants?

Output: Effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ef ficacy and safety of new oralanticoagulants?. ### Response: Effectiveness.


Instruction: What type of thromboembolism are new oral anticoagulants used for?

Output: cancer-associated acute venous

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of thromboembolism are new oral anticoagulants used for?. ### Response: cancer-associated acute venous.


Instruction: What is the name of the journal that studies the safety and efficacy of anticoagulant in cancer-associated acute venous embolism?

Output: JAMA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies the safety and efficacy of anticoagulant in cancer-associated acute venous embolism?. ### Response: JAMA.


Instruction: What was the name of the book published by NI CE 2018?

Output: Chronic Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the book published by NI CE 2018?. ### Response: Chronic Heart Failure.


Instruction: What did the authors of Chronic Heart Failure Methods do to ensure the quality of their search strategies?

Output: cross -checking reference lists of highly relevant papers, analysing search strategies in other systematic reviews, and asking committee  members to highlight any additional studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the authors of Chronic Heart Failure Methods do to ensure the quality of their search strategies?. ### Response: cross -checking reference lists of highly relevant papers, analysing search strategies in other systematic reviews, and asking committee  members to highlight any additional studies.


Instruction: What did a second information specialist do before being run?

Output: Searches were quality assured

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a second information specialist do before being run?. ### Response: Searches were quality assured.


Instruction: What is in appendix N of a systematic review?

Output: The health economic search strategies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is in appendix N of a systematic review?. ### Response: The health economic search strategies.


Instruction: What were the titles and abstracts of records retrieved by the searches sifted for?

Output: relevance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the titles and abstracts of records retrieved by the searches sifted for?. ### Response: relevance.


Instruction: What were potentially significant publications obtained in full text?

Output: The titles and abstracts of records

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were potentially significant publications obtained in full text?. ### Response: The titles and abstracts of records.


Instruction: What was conducted on the websites listed below from organ isations relevant to the topic?

Output: a search was  conducted for guidelines and reports

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was conducted on the websites listed below from organ isations relevant to the topic?. ### Response: a search was  conducted for guidelines and reports.


Instruction: What was the name of the National Guideline Clearing House?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the National Guideline Clearing House?. ### Response: www.guideline.gov.


Instruction: What does NICE stand for?

Output: National Institute for Health and Care Excellence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does NICE stand for?. ### Response: National Institute for Health and Care Excellence.


Instruction: What is the acronym for National Institute for Health and Care Excellence?

Output: NICE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for National Institute for Health and Care Excellence?. ### Response: NICE.


Instruction: Where is the National Institutes of Health Consensus Development Program located?

Output: nih.gov

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the National Institutes of Health Consensus Development Program located?. ### Response: nih.gov.


Instruction: What is the name of the Royal College of General Practitioners?

Output: w.rcgp.org.uk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Royal College of General Practitioners?. ### Response: w.rcgp.org.uk.


Instruction: What was not undertaken?

Output: Searching for unpublished literature

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not undertaken?. ### Response: Searching for unpublished literature.


Instruction: The NGC and NICE do not have access to what?

Output: drug manufacturers’ unpublished clinical trial results

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The NGC and NICE do not have access to what?. ### Response: drug manufacturers’ unpublished clinical trial results.


Instruction: What may be different from that considered by the MHRA and European Medicines Agency for the purposes of licensing and safety regulation?

Output: clinical evidence considered by the committee for pharmaceutical interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be different from that considered by the MHRA and European Medicines Agency for the purposes of licensing and safety regulation?. ### Response: clinical evidence considered by the committee for pharmaceutical interventions.


Instruction: What was undertaken to identify health economic evidence?

Output: Systematic literature searches

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was undertaken to identify health economic evidence?. ### Response: Systematic literature searches.


Instruction: What was the purpose of the searches?

Output: to identify health economic evidence within published literature relevant to the review questions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the purpose of the searches?. ### Response: to identify health economic evidence within published literature relevant to the review questions.


Instruction: Where was the evidence of heart failure found?

Output: NHS Economic Evaluation Database

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where was the evidence of heart failure found?. ### Response: NHS Economic Evaluation Database.


Instruction: What database was used to identify the evidence for heart failure?

Output: NHS Economic Evaluation Database

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What database was used to identify the evidence for heart failure?. ### Response: NHS Economic Evaluation Database.


Instruction: What is HTA?

Output: Health Technology Assessment database

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is HTA?. ### Response: Health Technology Assessment database.


Instruction: When did HTA cease to be updated?

Output: March 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did HTA cease to be updated?. ### Response: March 2015.


Instruction: How was the search run on M edline and Embase?

Output: using a health economic filter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the search run on M edline and Embase?. ### Response: using a health economic filter.


Instruction: What filter did the search use?

Output: health economic filter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What filter did the search use?. ### Response: health economic filter.


Instruction: When was the quality of life search run on Medline and Embase?

Output: January 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the quality of life search run on Medline and Embase?. ### Response: January 2002.


Instruction: What was the filter used for the search?

Output: health economic filter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the filter used for the search?. ### Response: health economic filter.


Instruction: Where was the search restricted to papers?

Output: published in English

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where was the search restricted to papers?. ### Response: published in English.


Instruction: When were searches restricted to papers published in English?

Output: Where possible

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When were searches restricted to papers published in English?. ### Response: Where possible.