Instruction: What is the name of the systematic review of statin-drug interac-tions in older people?

Output: PROSPER study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review of statin-drug interac-tions in older people?. ### Response: PROSPER study.


Instruction: What is atorvastatin used for in Alzheimer disease?

Output: Randomized controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is atorvastatin used for in Alzheimer disease?. ### Response: Randomized controlled trial.


Instruction: What is the PROSPER study?

Output: Testing cognitive function in elderly populations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the PROSPER study?. ### Response: Testing cognitive function in elderly populations.


Instruction: What is pravastatin used for in the Elderly at Risk?

Output: Testing cognitive function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is pravastatin used for in the Elderly at Risk?. ### Response: Testing cognitive function.


Instruction: When did the J Neurol Neurosurg Psychiatry issue 73:385-9?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the J Neurol Neurosurg Psychiatry issue 73:385-9?. ### Response: 2002.


Instruction: How does statin therapy affect mortality in patients with cardiovascular disease?

Output: intensity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does statin therapy affect mortality in patients with cardiovascular disease?. ### Response: intensity.


Instruction: What is pravastatin and cogni-tive function in the elderly?

Output: Prevention of cardiovascular events and death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is pravastatin and cogni-tive function in the elderly?. ### Response: Prevention of cardiovascular events and death.


Instruction: What is the name of the randomized, double-blind, placebo-controlled trial of simvastin to treat Alzheimer disease?

Output: LEADe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized, double-blind, placebo-controlled trial of simvastin to treat Alzheimer disease?. ### Response: LEADe.


Instruction: What does statins reduce the risk of infarction in patients with heart failure?

Output: mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does statins reduce the risk of infarction in patients with heart failure?. ### Response: mortality.


Instruction: What did the PROSPER study do?

Output: Testing cognitive function in elderly populations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the PROSPER study do?. ### Response: Testing cognitive function in elderly populations.


Instruction: When was the J Neurol.257:85-90 published?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Neurol.257:85-90 published?. ### Response: 2010.


Instruction: What is rosuvastatin used for in older patients with systolic heart failure?

Output: mortality in patients with atheroscle-rotic cardiovascular disease. JAMA Cardiol. 2017;2:47–54. S4.1-35. Sano M, Bell KL, Galasko D, et al. A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is rosuvastatin used for in older patients with systolic heart failure?. ### Response: mortality in patients with atheroscle-rotic cardiovascular disease. JAMA Cardiol. 2017;2:47–54. S4.1-35. Sano M, Bell KL, Galasko D, et al. A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease.


Instruction: When did N Engl J Med issue 357:2248-61?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did N Engl J Med issue 357:2248-61?. ### Response: 2007.


Instruction: What is the GISSI-HF trial?

Output: a randomised, double-blind, placebo-controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the GISSI-HF trial?. ### Response: a randomised, double-blind, placebo-controlled trial.


Instruction: What was the name of the trial that evaluated rosuvastatin in patients with chronic heart failure?

Output: GISSI-HF trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the trial that evaluated rosuvastatin in patients with chronic heart failure?. ### Response: GISSI-HF trial.


Instruction: When was the LIPID Study Group conducted?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the LIPID Study Group conducted?. ### Response: 2008.


Instruction: Pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels?

Output: Prevention of cardiovascular events and death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels?. ### Response: Prevention of cardiovascular events and death.


Instruction: N Engl J Med. 1998; 339:1349-57. S4.1-41. What does evolocumab do?

Output: Low-density lipoprotein cholesterol lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: N Engl J Med. 1998; 339:1349-57. S4.1-41. What does evolocumab do?. ### Response: Low-density lipoprotein cholesterol lowering.


Instruction: What is the name of the FOURIER trial?

Output: Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the FOURIER trial?. ### Response: Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk.


Instruction: What is another name for Forteer Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk?

Output: FOURIER trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for Forteer Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk?. ### Response: FOURIER trial.


Instruction: When was the Circulation.137:338-50?

Output: 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circulation.137:338-50?. ### Response: 2018.


Instruction: What does therapy intensify in a population with atherosclerotic cardio-vascular disease?

Output: lipid-lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does therapy intensify in a population with atherosclerotic cardio-vascular disease?. ### Response: lipid-lowering.


Instruction: What is JAMA Cardiol. 2017;2:959-66?

Output: Simulation of lipid-lowering therapy intensification in a population with atherosclerotic cardio-vascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is JAMA Cardiol. 2017;2:959-66?. ### Response: Simulation of lipid-lowering therapy intensification in a population with atherosclerotic cardio-vascular disease.


Instruction: What year did NICE publish Chronic Heart Failure?

Output: 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did NICE publish Chronic Heart Failure?. ### Response: 2018.


Instruction: What is the name of the first author of the trial?

Output: Peters -klimm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the first author of the trial?. ### Response: Peters -klimm.


Instruction: Inpatient QoL Outcomes: Mort/ Hosp Meds Length (months) What is the last measure?

Output: Face -to-face meetings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Inpatient QoL Outcomes: Mort/ Hosp Meds Length (months) What is the last measure?. ### Response: Face -to-face meetings.


Instruction: Face -to-face meetings III-IV inine Del sindaco 200791 173 Italy Hospitalised, aged 70 or more, and discharged home?

Output: 978 -1-4731 -3093 -7 315 First Author / Trial name  n. Country  Recruitment  HFREF or both  Starts inpatient  QoL Outcomes:  Mort/ Hosp   Meds  Length (months) Last measure (months) Face -to-face meetings III-IV inine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Face -to-face meetings III-IV inine Del sindaco 200791 173 Italy Hospitalised, aged 70 or more, and discharged home?. ### Response: 978 -1-4731 -3093 -7 315 First Author / Trial name  n. Country  Recruitment  HFREF or both  Starts inpatient  QoL Outcomes:  Mort/ Hosp   Meds  Length (months) Last measure (months) Face -to-face meetings III-IV inine.


Instruction: How many patients were hospitalised with heart failure with NYHA II -IV and LV systolic dysfunction both On dc Nottingham?

Output: 2.2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were hospitalised with heart failure with NYHA II -IV and LV systolic dysfunction both On dc Nottingham?. ### Response: 2.2.


Instruction: What type of trial was Mejhert 2004 220 208 Sweden?

Output: OPTIMAL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of trial was Mejhert 2004 220 208 Sweden?. ### Response: OPTIMAL.


Instruction: What is LV systolic dysfunction both On dc Nottingham Health Profile Death, Admissions Px flex 6 -18m Ave 37 mean 2.2 attend PRICE trial Atienza 200422 153 Spain Cardiology ward with diagnosis of what?

Output: primary HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is LV systolic dysfunction both On dc Nottingham Health Profile Death, Admissions Px flex 6 -18m Ave 37 mean 2.2 attend PRICE trial Atienza 200422 153 Spain Cardiology ward with diagnosis of what?. ### Response: primary HF.


Instruction: What type of HF are patients recruited from PC with CHF and LVEF 50% HFREF?

Output: Low risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of HF are patients recruited from PC with CHF and LVEF 50% HFREF?. ### Response: Low risk.


Instruction: How many outpt Low risk (s table HF)– Long interventions?

Output: 28 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many outpt Low risk (s table HF)– Long interventions?. ### Response: 28 3.


Instruction: What percentage of HFREF is no SF-36* Death, Admissions Px 12 12 2 HICMan trial Peters -klimm 2010 257 197 Germany Patients recruited from PC with hospital admission with HF in last two years, objective CHF and LVEF are at least what?

Output: <45%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of HFREF is no SF-36* Death, Admissions Px 12 12 2 HICMan trial Peters -klimm 2010 257 197 Germany Patients recruited from PC with hospital admission with HF in last two years, objective CHF and LVEF are at least what?. ### Response: <45%.


Instruction: What type of death did Martensson have?

Output: No SF-36*

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of death did Martensson have?. ### Response: No SF-36*.


Instruction: What was the mean of the Northstar trial Schou?

Output: 8.6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean of the Northstar trial Schou?. ### Response: 8.6.


Instruction: Denmark Stable CHF on optimal meds, LVEF45% HFREF No MLWHF Death, Admissions Px, Adv. effects 24 (ave) 30 est 24 Varma 1999 352 83 UK Elderly patients recruited from inpatient or outpatient with diagnosis CHF?

Output: Denmark

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Denmark Stable CHF on optimal meds, LVEF45% HFREF No MLWHF Death, Admissions Px, Adv. effects 24 (ave) 30 est 24 Varma 1999 352 83 UK Elderly patients recruited from inpatient or outpatient with diagnosis CHF?. ### Response: Denmark.


Instruction: What is CHF?

Output: Stable CHF on optimal meds

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CHF?. ### Response: Stable CHF on optimal meds.


Instruction: What is SF-36* MLWHF Death, Admissions Adher -ence 12 12 4?

Output: *reported incompletely

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SF-36* MLWHF Death, Admissions Adher -ence 12 12 4?. ### Response: *reported incompletely.


Instruction: What is P.W. a coinvestigator on a grant regarding the treatment of subsegmentalPE?

Output: apixaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is P.W. a coinvestigator on a grant regarding the treatment of subsegmentalPE?. ### Response: apixaban.


Instruction: What is the use of vitamin K antagonists and direct oral anticoagulants?

Output: extended anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the use of vitamin K antagonists and direct oral anticoagulants?. ### Response: extended anticoagulation.


Instruction: Who has funded P. W.?

Output: Bristol-Myers Squibb

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who has funded P. W.?. ### Response: Bristol-Myers Squibb.


Instruction: Who has given honoraria for talks?

Output: P. W.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who has given honoraria for talks?. ### Response: P. W..


Instruction: What is the name of the company that gave P.W. grants?

Output: Bristol-Myers Squibb

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the company that gave P.W. grants?. ### Response: Bristol-Myers Squibb.


Instruction: What was the name of the last edition of the CHEST Antithrombotic Therapy for VTE DiseaseGuidelines?

Output: CHEST FEBRUARY 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the last edition of the CHEST Antithrombotic Therapy for VTE DiseaseGuidelines?. ### Response: CHEST FEBRUARY 2016.


Instruction: Who funded the study?

Output: American College of Chest Physicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who funded the study?. ### Response: American College of Chest Physicians.


Instruction: What is the name of the organization that funds the CHEST AntithromboticGuidelines?

Output: American College of Chest Physicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that funds the CHEST AntithromboticGuidelines?. ### Response: American College of Chest Physicians.


Instruction: What are the e-Tables and e -Figures located in?

Output: Supplemental Materials section of the online article

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the e-Tables and e -Figures located in?. ### Response: Supplemental Materials section of the online article.


Instruction: What is the name of the 9th ed edition of Antithrombotic Therapy and Prevention ofThrombosis?

Output: American College of Chest Physicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 9th ed edition of Antithrombotic Therapy and Prevention ofThrombosis?. ### Response: American College of Chest Physicians.


Instruction: What was the title of the 141(2 Suppl):e419S-494S?

Output: American College of Chest PhysiciansEvidence-Based Clinical Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the title of the 141(2 Suppl):e419S-494S?. ### Response: American College of Chest PhysiciansEvidence-Based Clinical Practice Guidelines.


Instruction: What is a potential solution to the vexing problem of guidelinesand con flict of interest?

Output: Evidence-Based Medicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a potential solution to the vexing problem of guidelinesand con flict of interest?. ### Response: Evidence-Based Medicine.


Instruction: What is the measurement tool to assess the methodological quality of systematic reviews?

Output: AMSTAR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the measurement tool to assess the methodological quality of systematic reviews?. ### Response: AMSTAR.


Instruction: What is the CochraneCollaboration's tool for assessing risk of bias in randomised trials?

Output: study limitations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the CochraneCollaboration's tool for assessing risk of bias in randomised trials?. ### Response: study limitations.


Instruction: What are the GRADE guidelines?

Output: 5. Rating the quality of evidence —publication bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the GRADE guidelines?. ### Response: 5. Rating the quality of evidence —publication bias.


Instruction: What is the risk of bias?

Output: study limitations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of bias?. ### Response: study limitations.


Instruction: How is the quality of evidence evaluated?

Output: —publication bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the quality of evidence evaluated?. ### Response: —publication bias.


Instruction: What was the name of the task force that grading strength of recommendations and quality of evidence in clinical guidelines was part of?

Output: american college of chest physicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the task force that grading strength of recommendations and quality of evidence in clinical guidelines was part of?. ### Response: american college of chest physicians.


Instruction: What did Guyatt GH, Oxman AD, Montori V, et al. do?

Output: GRADE guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Guyatt GH, Oxman AD, Montori V, et al. do?. ### Response: GRADE guidelines.


Instruction: When was the journal J ClinEpidemiol published?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the journal J ClinEpidemiol published?. ### Response: 2011.


Instruction: What is the name of the study that evaluated the quality of the evidence?

Output: J ClinEpidemiol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated the quality of the evidence?. ### Response: J ClinEpidemiol.


Instruction: What was the publication bias in the study?

Output: None declared

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the publication bias in the study?. ### Response: None declared.


Instruction: On Practice Guidelines. Circulation. 2014;129:2329–45.

Output: S49–73

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On Practice Guidelines. Circulation. 2014;129:2329–45.. ### Response: S49–73.


Instruction: What is the name of the Task Force on Practice Guidelines?

Output: American College of Cardiology Foundation/American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Practice Guidelines?. ### Response: American College of Cardiology Foundation/American Heart Association.


Instruction: Where can you find the Methodology Manual and Policies from the ACCF/AHA Task Force?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find the Methodology Manual and Policies from the ACCF/AHA Task Force?. ### Response: http://assets.cardiosource.com/Methodology_Manual_for_ACC_AHA_Writing_Committees.pdf.


Instruction: When was the methodology manual for ACC_AHA_Writing_Committees?

Output: April 9, 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the methodology manual for ACC_AHA_Writing_Committees?. ### Response: April 9, 2014.


Instruction: What is one of the AHA/ACC/HHS strategies to enhance application of clinical practice guidelines in patients with car -diovascular disease and comorbid conditions?

Output: management of heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the AHA/ACC/HHS strategies to enhance application of clinical practice guidelines in patients with car -diovascular disease and comorbid conditions?. ### Response: management of heart failure.


Instruction: What is another organization that contributes to the improvement of practice guidelines?

Output: US Department of Health and Human Services

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another organization that contributes to the improvement of practice guidelines?. ### Response: US Department of Health and Human Services.


Instruction: What was the name of the 2012 ACCF/AHA focused update of the guideline for the management of patients with unstable angina/non-ST-elevation myocardial infarction?

Output: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the 2012 ACCF/AHA focused update of the guideline for the management of patients with unstable angina/non-ST-elevation myocardial infarction?. ### Response: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.


Instruction: What is the acronym for the American Heart Association Task Force on Practice Guidelines?

Output: American College of Cardiology Foundation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the American Heart Association Task Force on Practice Guidelines?. ### Response: American College of Cardiology Foundation.


Instruction: What was the Circulation. 2012:126:875–910?

Output: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the Circulation. 2012:126:875–910?. ### Response: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.


Instruction: Who wrote the report Heart Disease and Stroke Statistics–2013 Update?

Output: Go AS, Mozaffarian D, Roger VL, et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote the report Heart Disease and Stroke Statistics–2013 Update?. ### Response: Go AS, Mozaffarian D, Roger VL, et al.


Instruction: What is the focus of the 2014 ACC/AHA/AATS/PCNA/SCAI/STS focused update of the guideline for the diagnosis and management of patients with stable ischemic heart disease?

Output: assessment of cardiovascular risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the focus of the 2014 ACC/AHA/AATS/PCNA/SCAI/STS focused update of the guideline for the diagnosis and management of patients with stable ischemic heart disease?. ### Response: assessment of cardiovascular risk.


Instruction: What are the names of the authors of the 2012 guideline?

Output: Fihn SD, Gardin JM, Abrams J, et al. 2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, and the American College of Physicians, American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the authors of the 2012 guideline?. ### Response: Fihn SD, Gardin JM, Abrams J, et al. 2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, and the American College of Physicians, American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons.


Instruction: What does the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines focus on?

Output: ocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines focus on?. ### Response: ocardial infarction.


Instruction: What is the name of the group that compiled a report on the diagnosis and management of patients with stable ischemic heart disease?

Output: American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that compiled a report on the diagnosis and management of patients with stable ischemic heart disease?. ### Response: American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.


Instruction: What is the acronym for Society for Cardiovascular Angiography and Interventions?

Output: es Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Society for Cardiovascular Angiography and Interventions?. ### Response: es Association.


Instruction: When did Circulation. 2012 issue 126:e354-471?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circulation. 2012 issue 126:e354-471?. ### Response: 2014.


Instruction: Who wrote the 2014 AHA/ACC/HRS guideline for the management of atrial fibrillation patients?

Output: January CT, Wann LS, Alpert JS, et al. 2014 AHA/ACC/HRS guide-line for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote the 2014 AHA/ACC/HRS guideline for the management of atrial fibrillation patients?. ### Response: January CT, Wann LS, Alpert JS, et al. 2014 AHA/ACC/HRS guide-line for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society.


Instruction: What is the name of the Task Force on Practice Guidelines and the Heart Rhythm Society?

Output: American College of Cardiology/American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Practice Guidelines and the Heart Rhythm Society?. ### Response: American College of Cardiology/American Heart Association.


Instruction: What was the 2013 ACC/AHA guideline on the assessment of cardiovascular risk?

Output: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 2013 ACC/AHA guideline on the assessment of cardiovascular risk?. ### Response: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.


Instruction: What is the acronym for the American College of Cardiology/American Heart Association Task Force on Practice Guidelines?

Output: ACC/AHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the American College of Cardiology/American Heart Association Task Force on Practice Guidelines?. ### Response: ACC/AHA.


Instruction: What was the name of the 2013 ACCF/AHA guideline for the management of heart failure?

Output: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the 2013 ACCF/AHA guideline for the management of heart failure?. ### Response: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.


Instruction: How is variant risk score associated with drug-induced QT prolon-gation and torsade de pointes risk?

Output: a pilot study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is variant risk score associated with drug-induced QT prolon-gation and torsade de pointes risk?. ### Response: a pilot study.


Instruction: What is a pilot study?

Output: variant risk score is associated with drug-induced QT prolon-gation and torsade de pointes risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a pilot study?. ### Response: variant risk score is associated with drug-induced QT prolon-gation and torsade de pointes risk.


Instruction: What type of sequencing implicates an increased burden of rare potassium channel variants in the risk of drug-induced long QT interval syndrome?

Output: Exome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of sequencing implicates an increased burden of rare potassium channel variants in the risk of drug-induced long QT interval syndrome?. ### Response: Exome.


Instruction: What year did Circulation. 2002:105:1943–8. S10.7-19?

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Circulation. 2002:105:1943–8. S10.7-19?. ### Response: 2017.


Instruction: What is the name of the trial that evaluated the effects of encainide, flecainid, or placebo?

Output: The Cardiac Arrhythmia Suppression Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the trial that evaluated the effects of encainide, flecainid, or placebo?. ### Response: The Cardiac Arrhythmia Suppression Trial.


Instruction: What was the outcome of the Cardiac Arrhythmia Suppression Trial?

Output: Mortality and morbidity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome of the Cardiac Arrhythmia Suppression Trial?. ### Response: Mortality and morbidity.


Instruction: When did the Lancet publish a report on oral mexiletine in high risk patients?

Output: 1980

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Lancet publish a report on oral mexiletine in high risk patients?. ### Response: 1980.


Instruction: What is a high-risk patient after a myocardial infarction?

Output: Oral mexiletine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a high-risk patient after a myocardial infarction?. ### Response: Oral mexiletine.


Instruction: What is the name of the UK Rythmodan Multicentre Study Group?

Output: U. K. Rythmodan Multicentre Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the UK Rythmodan Multicentre Study Group?. ### Response: U. K. Rythmodan Multicentre Study Group.


Instruction: When did Crijns HJ, Van Gelder IC, LieKI, and Lie KJ die?

Output: December 26, 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Crijns HJ, Van Gelder IC, LieKI, and Lie KJ die?. ### Response: December 26, 2016.


Instruction: What is the name of the syndrome caused by flecainide?

Output: Brugada” syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the syndrome caused by flecainide?. ### Response: Brugada” syndrome.


Instruction: What are the clinical characteristics and risk factors of drug-induced Brugada syndrome?

Output: Konigstein M, Rosso R, Topaz G, et al. Drug-induced Brugada syndrome: clinical characteristics and risk factors. Heart Rhythm. 2016;13:1083–7. S10.7-26

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the clinical characteristics and risk factors of drug-induced Brugada syndrome?. ### Response: Konigstein M, Rosso R, Topaz G, et al. Drug-induced Brugada syndrome: clinical characteristics and risk factors. Heart Rhythm. 2016;13:1083–7. S10.7-26.


Instruction: What is Brugada syndrome mimicked by?

Output: tricyclic antidepressant overdose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Brugada syndrome mimicked by?. ### Response: tricyclic antidepressant overdose.


Instruction: What is the name of the drug that induced the electrocardiographic pattern induced by cocaine?

Output: Brugada

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug that induced the electrocardiographic pattern induced by cocaine?. ### Response: Brugada.


Instruction: When was the Mayo Clin Proc. 2000?

Output: 75:845–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Mayo Clin Proc. 2000?. ### Response: 75:845–.


Instruction: What is the name of the drug that is available at http://www.brugadadrugs.org?

Output: Brugada drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug that is available at http://www.brugadadrugs.org?. ### Response: Brugada drugs.


Instruction: When was the last time the drug was available?

Output: October 6, 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last time the drug was available?. ### Response: October 6, 2016.


Instruction: What drug did dogs receive treatment for electrophysiologic effects?

Output: O-desmethyl encainide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug did dogs receive treatment for electrophysiologic effects?. ### Response: O-desmethyl encainide.


Instruction: What is the name of the drug that reverses the proarrhythmic effects of flecainide acetate?

Output: pro-pranolol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug that reverses the proarrhythmic effects of flecainide acetate?. ### Response: pro-pranolol.


Instruction: How many people died from a life-threatening overdose?

Output: 33:1840–5. S10.7-32

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people died from a life-threatening overdose?. ### Response: 33:1840–5. S10.7-32.


Instruction: What are the names of the two drugs that reversed the effects of pro-pranolol?

Output: flecainide acetate and encainide hydrochloride

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the two drugs that reversed the effects of pro-pranolol?. ### Response: flecainide acetate and encainide hydrochloride.


Instruction: Where can you find credible meds?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find credible meds?. ### Response: http://www.crediblemeds.org.


Instruction: What predicts life-threatening ventricular arrhythmia and death in adults with repaired tetralogy of fallot?

Output: Left ventricular longitu-dinal function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What predicts life-threatening ventricular arrhythmia and death in adults with repaired tetralogy of fallot?. ### Response: Left ventricular longitu-dinal function.


Instruction: DAPT with aspirin and either clopidogrel or prasugrel has increased the risk of ICH in several clinical trials and patient populations.

Output: 260

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: DAPT with aspirin and either clopidogrel or prasugrel has increased the risk of ICH in several clinical trials and patient populations.. ### Response: 260.


Instruction: What was the number of patients with prior stroke in PLATO?

Output: small

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the number of patients with prior stroke in PLATO?. ### Response: small.


Instruction: What is the power to detect treatment differences in intracranial bleeding in this subgroup?

Output: abciximab

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the power to detect treatment differences in intracranial bleeding in this subgroup?. ### Response: abciximab.


Instruction: What would it seem prudent to weigh when the addition of ticagrelor to aspirin is considered in patients with prior stroke?

Output: increased risk of intracranial bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would it seem prudent to weigh when the addition of ticagrelor to aspirin is considered in patients with prior stroke?. ### Response: increased risk of intracranial bleeding.


Instruction: What was established largely before the use of oral DAPT?

Output: Evidence to support the use of intravenous GP IIb/IIIa recep-tor antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was established largely before the use of oral DAPT?. ### Response: Evidence to support the use of intravenous GP IIb/IIIa recep-tor antagonists.


Instruction: What has failed to show benefit with the administration of “upstream” GP IIb/IIIa receptor antagonists?

Output: several studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has failed to show benefit with the administration of “upstream” GP IIb/IIIa receptor antagonists?. ### Response: several studies.


Instruction: What has suggested that abciximab may be useful in this setting?

Output: a meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has suggested that abciximab may be useful in this setting?. ### Response: a meta-analysis.


Instruction: The adjunctive use of GP IIb/IIIa agents at the time of PCI in the setting of DAPT has suggested what?

Output: failed to show benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The adjunctive use of GP IIb/IIIa agents at the time of PCI in the setting of DAPT has suggested what?. ### Response: failed to show benefit.


Instruction: What can be considered on an individual basis for large thrombus burden or inadequate P2Y12 receptor antagonist loading?

Output: GP IIb/IIIa agents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be considered on an individual basis for large thrombus burden or inadequate P2Y12 receptor antagonist loading?. ### Response: GP IIb/IIIa agents.


Instruction: What is not recommended for patients receiving bivalirudin as the primary anticoagulant?

Output: routine adjunctive use of GP IIb/IIIa inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended for patients receiving bivalirudin as the primary anticoagulant?. ### Response: routine adjunctive use of GP IIb/IIIa inhibitors.


Instruction: What is not recommended248 but may be considered as adjunctive or “bail-out” therapy in selected cases?

Output: GP IIb/IIIa inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended248 but may be considered as adjunctive or “bail-out” therapy in selected cases?. ### Response: GP IIb/IIIa inhibitors.


Instruction: Studies of intracoronary GP IIb/IIIa administra-tion during primary PCI have shown mixed results for what?

Output: a variety of surrogate and combined clinical endpoints

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Studies of intracoronary GP IIb/IIIa administra-tion during primary PCI have shown mixed results for what?. ### Response: a variety of surrogate and combined clinical endpoints.


Instruction: What may be reasonable in select cases?

Output: Use of intracoro-nary abciximab

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be reasonable in select cases?. ### Response: Use of intracoro-nary abciximab.


Instruction: What is recommended for patients with STEMI undergoing primary PCI?

Output: supportive anticoagulant regimens

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for patients with STEMI undergoing primary PCI?. ### Response: supportive anticoagulant regimens.


Instruction: What is the level of evidence for bivalirudin with or without prior treatment with UFH.248?

Output: B)Class IIa1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the level of evidence for bivalirudin with or without prior treatment with UFH.248?. ### Response: B)Class IIa1.


Instruction: In patients with STEMI undergoing PCI who are at risk for PCI, who is at risk of PCI?

Output: bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with STEMI undergoing PCI who are at risk for PCI, who is at risk of PCI?. ### Response: bleeding.


Instruction: What type of patients are at high risk of bleeding?

Output: STEMI undergoing PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of patients are at high risk of bleeding?. ### Response: STEMI undergoing PCI.


Instruction: What is the preferred treatment for patients with STEMI undergoing PCI?

Output: bivaliru-din monotherapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the preferred treatment for patients with STEMI undergoing PCI?. ### Response: bivaliru-din monotherapy.


Instruction: Fondaparinux should not be used as the sole antico-agulant to support what type of PCI?

Output: primary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Fondaparinux should not be used as the sole antico-agulant to support what type of PCI?. ### Response: primary.


Instruction: What is the risk of catheter thrombosis?

Output: large thrombus burden

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of catheter thrombosis?. ### Response: large thrombus burden.


Instruction: What is NICE 2018?

Output: Chronic Heart Failure  Referral and approach to care  © NICE 2018. All rights reserved

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE 2018?. ### Response: Chronic Heart Failure  Referral and approach to care  © NICE 2018. All rights reserved.


Instruction: What is the study population risk strand Length strand Intervention strand

Output: J-HOMECARE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the study population risk strand Length strand Intervention strand. ### Response: J-HOMECARE.


Instruction: What trial did Tsuchihashi -makaya 2013341 run?

Output: J-HOMECARE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What trial did Tsuchihashi -makaya 2013341 run?. ### Response: J-HOMECARE.


Instruction: What was the name of the high mid case management trial that Ledwidge ran?

Output: Atienza

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the high mid case management trial that Ledwidge ran?. ### Response: Atienza.


Instruction: Who ran the High Short MDT clinic?

Output: Martensson

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who ran the High Short MDT clinic?. ### Response: Martensson.


Instruction: What was the name of the trial Schou 2013 300 Schou 2014 298 Low Long MDT clinic Nucifora 2006 244 High Mid MDT Clinic OPTIMAL trial Mejhert 2004 220 High Long Nurse-led clinic PREFER trial Brannstrom 2014 50 Brannström 2013 49 Sahlen 2016 290 High MidMDT clinic

Output: NorthStar trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the trial Schou 2013 300 Schou 2014 298 Low Long MDT clinic Nucifora 2006 244 High Mid MDT Clinic OPTIMAL trial Mejhert 2004 220 High Long Nurse-led clinic PREFER trial Brannstrom 2014 50 Brannström 2013 49 Sahlen 2016 290 High MidMDT clinic. ### Response: NorthStar trial.


Instruction: What year was Brannstrom 50?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was Brannstrom 50?. ### Response: 2014.


Instruction: Which year was Sahlen 2016 290 High Mid Home -based MDT PRICE trial Atienza 200422 Ojeda 2005246 High Long MDT clinic?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which year was Sahlen 2016 290 High Mid Home -based MDT PRICE trial Atienza 200422 Ojeda 2005246 High Long MDT clinic?. ### Response: 2007.


Instruction: What is the name of the low long MDT clinic in Varma?

Output: Nucifora

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the low long MDT clinic in Varma?. ### Response: Nucifora.


Instruction: What did the intervention group demon-strate immediately after the program?

Output: better stroke awareness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the intervention group demon-strate immediately after the program?. ### Response: better stroke awareness.


Instruction: By 3 months after intervention, test scores had declined, highlighting the need for reinforcement?

Output: statistically still more knowledgeable than the control group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: By 3 months after intervention, test scores had declined, highlighting the need for reinforcement?. ### Response: statistically still more knowledgeable than the control group.


Instruction: The intervention did not affect rates of what?

Output: smoking or positive changes in diet and physical activity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The intervention did not affect rates of what?. ### Response: smoking or positive changes in diet and physical activity.


Instruction: What did not affect rates of smoking or positive changes in diet and physical activity?

Output: The inter -vention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did not affect rates of smoking or positive changes in diet and physical activity?. ### Response: The inter -vention.


Instruction: What can be part of a broader sys-tem to educate and reinforce?

Output: The ED

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be part of a broader sys-tem to educate and reinforce?. ### Response: The ED.


Instruction: What will strain the capacity of many EDs to provide even basic emergency care to acutely ill patients?

Output: increasing demands for emergent and primary care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will strain the capacity of many EDs to provide even basic emergency care to acutely ill patients?. ### Response: increasing demands for emergent and primary care.


Instruction: To effectively incorporate preventive services into routine ED practice, a careful review of feasibility and cost-effectiveness is required of each intervention.

Output: 896

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: To effectively incorporate preventive services into routine ED practice, a careful review of feasibility and cost-effectiveness is required of each intervention.. ### Response: 896.


Instruction: What is required of each intervention assuming that sufficient resources are available?

Output: a care-ful review of feasibility and cost-effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is required of each intervention assuming that sufficient resources are available?. ### Response: a care-ful review of feasibility and cost-effectiveness.


Instruction: Effective primary, secondary, and tertiary stroke prevention can occur in what ED?

Output: EDs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Effective primary, secondary, and tertiary stroke prevention can occur in what ED?. ### Response: EDs.


Instruction: Significant healthcare organi-zational changes are required to address current limitations of what?

Output: health promotion training for healthcare providers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Significant healthcare organi-zational changes are required to address current limitations of what?. ### Response: health promotion training for healthcare providers.


Instruction: What does promotion training for healthcare providers focus on?

Output: program funding, resource availability, and opportu-nities for timely referral for longitudinal care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does promotion training for healthcare providers focus on?. ### Response: program funding, resource availability, and opportu-nities for timely referral for longitudinal care.


Instruction: When was this article downloaded from http://ahajournals.org?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this article downloaded from http://ahajournals.org?. ### Response: April 28, 2023.


Instruction: What is Echocardiography-3D TEE for assessment of valve disease used for?

Output: comprehensive TTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Echocardiography-3D TEE for assessment of valve disease used for?. ### Response: comprehensive TTE.


Instruction: What is the name of the team that provides Vascular surgery support?

Output: Neurology stroke team

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the team that provides Vascular surgery support?. ### Response: Neurology stroke team.


Instruction: What is a comprehensive TTE for assessment of valve disease?

Output: Echocardiography–3D TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a comprehensive TTE for assessment of valve disease?. ### Response: Echocardiography–3D TEE.


Instruction: When was this document downloaded?

Output: April 27, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this document downloaded?. ### Response: April 27, 2023.


Instruction: Where did this document come from?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where did this document come from?. ### Response: http://ahajournals.org.


Instruction: What is of value if rection of MR is delayed beyond the onset of triggers?

Output: referral to a Comprehensive Valve Center for early repair or careful surveillance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is of value if rection of MR is delayed beyond the onset of triggers?. ### Response: referral to a Comprehensive Valve Center for early repair or careful surveillance.


Instruction: What should be con-firmed by repeat sequential TTE?

Output: management decisions that rest on these measurements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be con-firmed by repeat sequential TTE?. ### Response: management decisions that rest on these measurements.


Instruction: In patients with milder chronic pain, what should be done?

Output: TTE is indicated periodically to evaluate for changes in MR severity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with milder chronic pain, what should be done?. ### Response: TTE is indicated periodically to evaluate for changes in MR severity.


Instruction: How is MR confirmed by repeat sequential TTE?

Output: echocardiographic measure-ments are variable, management decisions that rest on these measurements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is MR confirmed by repeat sequential TTE?. ### Response: echocardiographic measure-ments are variable, management decisions that rest on these measurements.


Instruction: In patients with milder chronic primary MR (Stages A and B), TTE is indicated periodically to evaluate for changes in what?

Output: MR severity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with milder chronic primary MR (Stages A and B), TTE is indicated periodically to evaluate for changes in what?. ### Response: MR severity.


Instruction: What is a crucial demarcation point in the natural history of MR?

Output: Symptom onset

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a crucial demarcation point in the natural history of MR?. ### Response: Symptom onset.


Instruction: What is also a trigger for intervention?

Output: Symptom onset

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is also a trigger for intervention?. ### Response: Symptom onset.


Instruction: What may patients fail to recognize or ignore because symptoms develop gradually?

Output: symp-toms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may patients fail to recognize or ignore because symptoms develop gradually?. ### Response: symp-toms.


Instruction: Natriuretic peptide levels provide objective evidence in patients with what?

Output: chronic severe MR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Natriuretic peptide levels provide objective evidence in patients with what?. ### Response: chronic severe MR.


Instruction: What is used as a key determi-nant of LV function in timing MR intervention?

Output: LVEF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used as a key determi-nant of LV function in timing MR intervention?. ### Response: LVEF.


Instruction: What does LVEF often overestimate in MR?

Output: LV function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does LVEF often overestimate in MR?. ### Response: LV function.


Instruction: What does global longi-tudinal strain appear more sensitive to in patients with chronic MR?

Output: LV dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does global longi-tudinal strain appear more sensitive to in patients with chronic MR?. ### Response: LV dysfunction.


Instruction: What might give warning that LV function is declining before LVEF becomes abnormal?

Output: Global longi-tudinal strain

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What might give warning that LV function is declining before LVEF becomes abnormal?. ### Response: Global longi-tudinal strain.


Instruction: What is a novel marker of LV systolic function?

Output: global longitudi-nal strain

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a novel marker of LV systolic function?. ### Response: global longitudi-nal strain.


Instruction: What may be useful adjuncts in assessing LV function in patients with chronic MR?

Output: global longitudi-nal strain

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be useful adjuncts in assessing LV function in patients with chronic MR?. ### Response: global longitudi-nal strain.


Instruction: What tests are inconclusive or discordant with regard to 1) severity of MR, 2) LV function, or 3) the need for surgery?

Output: noninvasive tests

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What tests are inconclusive or discordant with regard to 1) severity of MR, 2) LV function, or 3) the need for surgery?. ### Response: noninvasive tests.


Instruction: Noninvasive imaging is adequate for evaluation of what?

Output: MR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Noninvasive imaging is adequate for evaluation of what?. ### Response: MR.


Instruction: What may be necessary in some cases when there is a clinical discrepancy?

Output: invasive hemodynamic evalu-ation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be necessary in some cases when there is a clinical discrepancy?. ### Response: invasive hemodynamic evalu-ation.


Instruction: What support a cardiac cause of dyspnea?

Output: Elevated filling pressures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What support a cardiac cause of dyspnea?. ### Response: Elevated filling pressures.


Instruction: What may indicate severely abnormal pathophysiology even when the patient claims to be asymptomatic?

Output: Elevated filling pressures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may indicate severely abnormal pathophysiology even when the patient claims to be asymptomatic?. ### Response: Elevated filling pressures.


Instruction: What is a normal invasive hemodynamic examination in a symptomatic?

Output: symp-toms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a normal invasive hemodynamic examination in a symptomatic?. ### Response: symp-toms.


Instruction: When was this document downloaded?

Output: April 27, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this document downloaded?. ### Response: April 27, 2023.


Instruction: What is lowing major noncardiac surgery?

Output: Angiotensin converting enzyme inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is lowing major noncardiac surgery?. ### Response: Angiotensin converting enzyme inhibitors.


Instruction: What is not associated with respiratory complications or mor -tality after non cardiac surgery? What is Rosenman DJ, McDonald FS, Ebbert JO, et al.?

Output: Angiotensin converting enzyme inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not associated with respiratory complications or mor -tality after non cardiac surgery? What is Rosenman DJ, McDonald FS, Ebbert JO, et al.?. ### Response: Angiotensin converting enzyme inhibitors.


Instruction: What is the difference between withholding and administering renin-angiotensin-aldosterone system antagonists in the preoperative period?

Output: Clinical conse-quences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between withholding and administering renin-angiotensin-aldosterone system antagonists in the preoperative period?. ### Response: Clinical conse-quences.


Instruction: When was the J Hosp Med.3:319–25?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Hosp Med.3:319–25?. ### Response: 2008.


Instruction: What is an analysis of the Vascular events Indicator?

Output: Withholding versus con-tinuing angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers before noncardiac surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an analysis of the Vascular events Indicator?. ### Response: Withholding versus con-tinuing angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers before noncardiac surgery.


Instruction: What is an analysis of the Vascular events in noncardiac Surgery patIents cOhort evaluatioN Prospective Cohort?

Output: Withholding versus con-tinuing angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers before noncardiac surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an analysis of the Vascular events in noncardiac Surgery patIents cOhort evaluatioN Prospective Cohort?. ### Response: Withholding versus con-tinuing angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers before noncardiac surgery.


Instruction: What is Fleisher LA's specialty?

Output: Preoperative evaluation of the patient with hyperten-sion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Fleisher LA's specialty?. ### Response: Preoperative evaluation of the patient with hyperten-sion.


Instruction: When was JAMA's 2002 287:2043–6?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was JAMA's 2002 287:2043–6?. ### Response: 2002.


Instruction: Howell SJ, Sear JW, Foex P. Hypertension, hypertensive heart disease and what?

Output: perioperative cardiac risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Howell SJ, Sear JW, Foex P. Hypertension, hypertensive heart disease and what?. ### Response: perioperative cardiac risk.


Instruction: What is hypertensive heart disease and perioperative cardiac risk?

Output: Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hypertensive heart disease and perioperative cardiac risk?. ### Response: Hypertension.


Instruction: What is Hart GR, Anderson RJ. About withdrawal syndromes and the cessation of antihyperten-sive therapy?

Output: Withdrawal syndromes and the cessa-tion of antihypertensive therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Hart GR, Anderson RJ. About withdrawal syndromes and the cessation of antihyperten-sive therapy?. ### Response: Withdrawal syndromes and the cessa-tion of antihypertensive therapy.


Instruction: How many pages are in 1981?

Output: 1125–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many pages are in 1981?. ### Response: 1125–.


Instruction: What is extended-release metoprolol succinate called?

Output: non-cardiac surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is extended-release metoprolol succinate called?. ### Response: non-cardiac surgery.


Instruction: What is the POISE study group?

Output: a randomised controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the POISE study group?. ### Response: a randomised controlled trial.


Instruction: When was the Lancet 371:1839-47.

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Lancet 371:1839-47.. ### Response: 2008.


Instruction: What are the preoperative and intraoperative predictors of?

Output: postoperative myocar -dial infarction or ischemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the preoperative and intraoperative predictors of?. ### Response: postoperative myocar -dial infarction or ischemia.


Instruction: What is ischemia in noncardiac surgery patients?

Output: postoperative myocar -dial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ischemia in noncardiac surgery patients?. ### Response: postoperative myocar -dial infarction.


Instruction: What is the cancellation rate of hypertensive patients undergoing anaesthesia and elective surgery?

Output: S11.5-17

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cancellation rate of hypertensive patients undergoing anaesthesia and elective surgery?. ### Response: S11.5-17.


Instruction: What was the Br J Anaesth. 2001;86:789–93?

Output: Survey of cancellation rate of hypertensive patients undergoing anaesthesia and elective surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the Br J Anaesth. 2001;86:789–93?. ### Response: Survey of cancellation rate of hypertensive patients undergoing anaesthesia and elective surgery.


Instruction: Who wrote Acute postoperative hypertension: a review of therapeutic options?

Output: Haas CE, LeBlanc JM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote Acute postoperative hypertension: a review of therapeutic options?. ### Response: Haas CE, LeBlanc JM.


Instruction: What is the name of the com-parative study of clevidipine to nitroglycerin, sodium nitroprus-side, and nicardipine for acute hypertension treatment in cardiac surgery patients?

Output: ECLIPSE trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the com-parative study of clevidipine to nitroglycerin, sodium nitroprus-side, and nicardipine for acute hypertension treatment in cardiac surgery patients?. ### Response: ECLIPSE trials.


Instruction: What year did Anesth Analg publish 107:1110–21?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Anesth Analg publish 107:1110–21?. ### Response: 2008.


Instruction: What is the name of the systematic review and meta-analysis of clevidipine?

Output: PLoS ONE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta-analysis of clevidipine?. ### Response: PLoS ONE.


Instruction: When did the ACC/AHA guideline on perioperative cardiovascular evaluation and management of patients undergo noncardiac surgery come out?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the ACC/AHA guideline on perioperative cardiovascular evaluation and management of patients undergo noncardiac surgery come out?. ### Response: 2014.


Instruction: What is the name of the Task Force on Practice Guidelines?

Output: American College of Cardiology/American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Practice Guidelines?. ### Response: American College of Cardiology/American Heart Association.


Instruction: When will the document be available for download?

Output: May 3, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When will the document be available for download?. ### Response: May 3, 2023.


Instruction: What is reasonable even though itseffectiveness is unknown?

Output: dures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable even though itseffectiveness is unknown?. ### Response: dures.


Instruction: What is the class IIa, LOE B?

Output: seffectiveness is unknown

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the class IIa, LOE B?. ### Response: seffectiveness is unknown.


Instruction: Under these revised guidelines, many fewer patients would be candidatesto receive what?

Output: IE prophylaxis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Under these revised guidelines, many fewer patients would be candidatesto receive what?. ### Response: IE prophylaxis.


Instruction: What are the best interests of patients and healthcareproviders based on?

Output: the best available published dataand expert opinion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the best interests of patients and healthcareproviders based on?. ### Response: the best available published dataand expert opinion.


Instruction: What is the most common MVP?

Output: underlying conditionthat predisposes to acquisition of IE in the Western world

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common MVP?. ### Response: underlying conditionthat predisposes to acquisition of IE in the Western world.


Instruction: What is the most common underlying condition that predisposes to IE in the Western world?

Output: MVP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common underlying condition that predisposes to IE in the Western world?. ### Response: MVP.


Instruction: What is extremely low for the entire population with MVP?

Output: absolute incidence of endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is extremely low for the entire population with MVP?. ### Response: absolute incidence of endocarditis.


Instruction: Endocarditis is not usually associated with what?

Output: the grave outcome associated with the con-ditions identified in Table 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Endocarditis is not usually associated with what?. ### Response: the grave outcome associated with the con-ditions identified in Table 3.


Instruction: What is no longer recommended for this group of individuals?

Output: antibiotics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is no longer recommended for this group of individuals?. ### Response: antibiotics.


Instruction: The administration of prophylactic antibiotics is notrisk free, as discussed above.

Output: antibiotic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The administration of prophylactic antibiotics is notrisk free, as discussed above.. ### Response: antibiotic therapy.


Instruction: The widespread use of antibiotic therapy promotes the emergence of what?

Output: resistant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The widespread use of antibiotic therapy promotes the emergence of what?. ### Response: resistant.


Instruction: What is the most likely cause of endocarditis?

Output: MVP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most likely cause of endocarditis?. ### Response: MVP.


Instruction: What has the frequency of multidrug-resistant viridans group streptococci and entero-cocci increased dramatically during the past 2 decades?

Output: reduced the efficacy and num-ber of antibiotics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has the frequency of multidrug-resistant viridans group streptococci and entero-cocci increased dramatically during the past 2 decades?. ### Response: reduced the efficacy and num-ber of antibiotics.


Instruction: The increased resistance has reduced the efficacy and num-ber of what antibiotics available for the treatment of IE?

Output: streptococci and enterococci

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The increased resistance has reduced the efficacy and num-ber of what antibiotics available for the treatment of IE?. ### Response: streptococci and enterococci.


Instruction: What antibiotics are available for the treatment of IE?

Output: prophylactic antibiotics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What antibiotics are available for the treatment of IE?. ### Response: prophylactic antibiotics.


Instruction: What should an antibiotic for prophylaxis be administered in before the procedure?

Output: asingle dose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should an antibiotic for prophylaxis be administered in before the procedure?. ### Response: asingle dose.


Instruction: How long after the procedure can the dose of antibiotic be administered?

Output: 2 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after the procedure can the dose of antibiotic be administered?. ### Response: 2 hours.


Instruction: What should be considered only when the patient did not receive the pre-procedure dose?

Output: administration of the dosage after the procedures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered only when the patient did not receive the pre-procedure dose?. ### Response: administration of the dosage after the procedures.


Instruction: Some patients who are scheduled for an invasive procedure may have what?

Output: a coincidental endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Some patients who are scheduled for an invasive procedure may have what?. ### Response: a coincidental endocarditis.


Instruction: What should alert the provider to the possibility of?

Output: The presence of fever or other manifestations of systemicinfection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should alert the provider to the possibility of?. ### Response: The presence of fever or other manifestations of systemicinfection.


Instruction: What should alert the provider to the possibility of IE?

Output: The presence of fever or other manifestations of systemicinfection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should alert the provider to the possibility of IE?. ### Response: The presence of fever or other manifestations of systemicinfection.


Instruction: What should be obtained before administration of antibiotics?

Output: blood culturesand other relevant tests

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be obtained before administration of antibiotics?. ### Response: blood culturesand other relevant tests.


Instruction: What did previous AHA guidelines on prophylaxis list a substantial amount of?

Output: Regimens for Dental Procedures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did previous AHA guidelines on prophylaxis list a substantial amount of?. ### Response: Regimens for Dental Procedures.


Instruction: What year is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction?

Output: 2020

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction?. ### Response: 2020.


Instruction: What is the P age 106 of 127 B?

Output: VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the P age 106 of 127 B?. ### Response: VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020.


Instruction: Question 1 – Time to repeat screening for CV risk?

Output: VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Question 1 – Time to repeat screening for CV risk?. ### Response: VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction.


Instruction: Question 2 and 3 include specific terms for what?

Output: CV risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Question 2 and 3 include specific terms for what?. ### Response: CV risk.


Instruction: #1 Dyslipidemia exp dyslipidemias/ OR exp cholesterol/ OR what else?

Output: lipids

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: #1 Dyslipidemia exp dyslipidemias/ OR exp cholesterol/ OR what else?. ### Response: lipids.


Instruction: Hyperlipoproteinaemia* OR hypertriglyceridemia * OR hyperlipaemia OR cholesteryl* OR cholesterol* OR lipid* OR lipoprotein* OR tryglycer* OR triaclyglycerol* OR "HDL -C" OR "LDL-C") OR what else?

Output: cholesterol* OR lipid* OR lipoprotein* OR tryglycer* OR triaclyglycer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hyperlipoproteinaemia* OR hypertriglyceridemia * OR hyperlipaemia OR cholesteryl* OR cholesterol* OR lipid* OR lipoprotein* OR tryglycer* OR triaclyglycerol* OR "HDL -C" OR "LDL-C") OR what else?. ### Response: cholesterol* OR lipid* OR lipoprotein* OR tryglycer* OR triaclyglycer.


Instruction: What is another name for "HDL -C" OR "LDL C"?

Output: triaclyglycer*

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for "HDL -C" OR "LDL C"?. ### Response: triaclyglycer*.


Instruction: What does ADJ4 mean?

Output: test* or screen* OR assess*

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ADJ4 mean?. ### Response: test* or screen* OR assess*.


Instruction: What is another word for define or defining or predict or prediction or assess?

Output: ADJ4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another word for define or defining or predict or prediction or assess?. ### Response: ADJ4.


Instruction: What is the other word for classif or prioritiz or category?

Output: ADJ4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the other word for classif or prioritiz or category?. ### Response: ADJ4.


Instruction: What type of ADJ2 risk is #3 Repeat s creening/ monitoring Exp time factors/ OR Monitoring, Physiologic/ OR (rescreen* OR re -screen* Or surveillance OR what else?

Output: cardiovascular

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of ADJ2 risk is #3 Repeat s creening/ monitoring Exp time factors/ OR Monitoring, Physiologic/ OR (rescreen* OR re -screen* Or surveillance OR what else?. ### Response: cardiovascular.


Instruction: Repeat or repet* or replicat* or redo or "re-run" or subsequent* or redundant* or rerun or what else)

Output: "re -do

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Repeat or repet* or replicat* or redo or "re-run" or subsequent* or redundant* or rerun or what else). ### Response: "re -do.


Instruction: What does ADJ4 (test* or screen* OR assess*) do?

Output: define or defining or predict or prediction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ADJ4 (test* or screen* OR assess*) do?. ### Response: define or defining or predict or prediction.


Instruction: What is one of the outcomes of rerun or re-run?

Output: repeat or repet* or replicat* or redo or "re -do

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the outcomes of rerun or re-run?. ### Response: repeat or repet* or replicat* or redo or "re -do.


Instruction: What type of infarction is associated with a stroke?

Output: myocardial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of infarction is associated with a stroke?. ### Response: myocardial.


Instruction: What is a common cause of death associated with an ADJ attack?

Output: heart

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a common cause of death associated with an ADJ attack?. ### Response: heart.


Instruction: What is another word for heart ADJ infarct?

Output: myocardial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another word for heart ADJ infarct?. ### Response: myocardial.


Instruction: What is a word for secondary ADJ prevention?

Output: OR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a word for secondary ADJ prevention?. ### Response: OR.


Instruction: What is the limit to RCTs/SRs/Meta -analysis hedge?

Output: #6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the limit to RCTs/SRs/Meta -analysis hedge?. ### Response: #6.


Instruction: What are the limits to additional study designs?

Output: #7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the limits to additional study designs?. ### Response: #7.


Instruction: What is another term for retrospective studies?

Output: exp

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for retrospective studies?. ### Response: exp.


Instruction: What is a term for cross-over studies or crossover procedure?

Output: OR cross -over studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a term for cross-over studies or crossover procedure?. ### Response: OR cross -over studies.


Instruction: Which study is an example of a cross over study?

Output: observational study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which study is an example of a cross over study?. ### Response: observational study.


Instruction: What type of studies/ OR exp case -control studies/OR follow -up studies?

Output: validation studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of studies/ OR exp case -control studies/OR follow -up studies?. ### Response: validation studies.


Instruction: How many sets do you combine?

Output: #5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many sets do you combine?. ### Response: #5.


Instruction: What is more representative of patients in whom VKA therapy is well tolerated?

Output: patients already receiving VKA therapy at study entry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more representative of patients in whom VKA therapy is well tolerated?. ### Response: patients already receiving VKA therapy at study entry.


Instruction: In prespecifi ed subgroup analyses, the investigators did not find evidence of a difference in the effect of what on primary outcome?

Output: VKA therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In prespecifi ed subgroup analyses, the investigators did not find evidence of a difference in the effect of what on primary outcome?. ### Response: VKA therapy.


Instruction: What was the difference in the effect on major bleeding?

Output: -cant difference

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the difference in the effect on major bleeding?. ### Response: -cant difference.


Instruction: What did the difference depend on whether patients were prior users of?

Output: VKA therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the difference depend on whether patients were prior users of?. ### Response: VKA therapy.


Instruction: What was associated with a nonsignifi cant trend toward a 69% relative increase in major bleeding compared with dual antiplatelet therapy?

Output: VKA therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with a nonsignifi cant trend toward a 69% relative increase in major bleeding compared with dual antiplatelet therapy?. ### Response: VKA therapy.


Instruction: What was VKA therapy associated with at study entry?

Output: a nonsigniﬁ  cant trend toward a 24% relative decrease in major bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was VKA therapy associated with at study entry?. ### Response: a nonsigniﬁ  cant trend toward a 24% relative decrease in major bleeding.


Instruction: What was the relative decrease in major bleeding associated with dual antiplatelet therapy?

Output: 24%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the relative decrease in major bleeding associated with dual antiplatelet therapy?. ### Response: 24%.


Instruction: What was the name of the study that compared aspirin and clopid-ogrel therapy?

Output: ACTIVE A

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the study that compared aspirin and clopid-ogrel therapy?. ### Response: ACTIVE A.


Instruction: How many patients were enrolled in the ACTIVE study?

Output: 7,554

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were enrolled in the ACTIVE study?. ### Response: 7,554.


Instruction: What percentage of patients were considered unsuitable for VKA therapy because of a physician's judgment?

Output: one-half

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients were considered unsuitable for VKA therapy because of a physician's judgment?. ### Response: one-half.


Instruction: Why was VKA inappropriate?

Output: a physician’s judg-ment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was VKA inappropriate?. ### Response: a physician’s judg-ment.


Instruction: Why was one-fourth of patients choosing not to take a VKA?

Output: because of a speciﬁ  c risk of bleeding, and one-fourth because of the patient’s preference not to take a VKA as the sole reason

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was one-fourth of patients choosing not to take a VKA?. ### Response: because of a speciﬁ  c risk of bleeding, and one-fourth because of the patient’s preference not to take a VKA as the sole reason.


Instruction: What is combination therapy more effective in reducing in patients with AF?

Output: the risk of nonfatal stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is combination therapy more effective in reducing in patients with AF?. ### Response: the risk of nonfatal stroke.


Instruction: What increases the risk of nonfatal stroke in patients with AF?

Output: combination therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What increases the risk of nonfatal stroke in patients with AF?. ### Response: combination therapy.


Instruction: What does aspirin alone increase?

Output: the risk of non-fatal major extracranial bleeds

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does aspirin alone increase?. ### Response: the risk of non-fatal major extracranial bleeds.


Instruction: Why is anti-thrombotic therapy for AF evolving rapidly?

Output: the development of new oral anticoagulants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is anti-thrombotic therapy for AF evolving rapidly?. ### Response: the development of new oral anticoagulants.