Instruction: What was the adjusted OR for 6 studies?

Output: 1.29

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the adjusted OR for 6 studies?. ### Response: 1.29.


Instruction: How much higher was the risk of stroke among individuals with migraine?

Output: significantly higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much higher was the risk of stroke among individuals with migraine?. ### Response: significantly higher.


Instruction: What was the RR of migraine with aura?

Output: 2.16

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the RR of migraine with aura?. ### Response: 2.16.


Instruction: What was a significant risk of stroke among women?

Output: Migraine headache

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a significant risk of stroke among women?. ### Response: Migraine headache.


Instruction: What was the RR among women?

Output: 2.08

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the RR among women?. ### Response: 2.08.


Instruction: What was it among men?

Output: RR, 1.37

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was it among men?. ### Response: RR, 1.37.


Instruction: How did smoking increase the risk?

Output: OC use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did smoking increase the risk?. ### Response: OC use.


Instruction: What did the Work Group believe were not applicable to CKD patients?

Output: AHA/ACC lifestyle guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Work Group believe were not applicable to CKD patients?. ### Response: AHA/ACC lifestyle guidelines.


Instruction: What was the purpose of the AHA/ACC guidelines?

Output: primary prevention of CVdisease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the purpose of the AHA/ACC guidelines?. ### Response: primary prevention of CVdisease.


Instruction: What is not applicable to CKD patients?

Output: physical activity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not applicable to CKD patients?. ### Response: physical activity.


Instruction: What was the target set forth by the AHA/ACC guidelines for moderate-intensity physical activity for a cumulative duration of atleast 150 minutes per week?

Output: applicable to hypertensive CKD patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the target set forth by the AHA/ACC guidelines for moderate-intensity physical activity for a cumulative duration of atleast 150 minutes per week?. ### Response: applicable to hypertensive CKD patients.


Instruction: How many minutes of physical activity per week was adopted for hypertensive CKD patients?

Output: 150

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many minutes of physical activity per week was adopted for hypertensive CKD patients?. ### Response: 150.


Instruction: What should be individualized according to their cognitive, CV, and physical tolerance?

Output: the degree ofphysical activity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be individualized according to their cognitive, CV, and physical tolerance?. ### Response: the degree ofphysical activity.


Instruction: What should be considered when deciding on the implementation and intensity of physical activity interventions in individual patients?

Output: The form and intensity of physicalactivity should be considered and modi ﬁed as necessary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered when deciding on the implementation and intensity of physical activity interventions in individual patients?. ### Response: The form and intensity of physicalactivity should be considered and modi ﬁed as necessary.


Instruction: What should be considered and modi fid as necessary inindividual patients?

Output: The form and intensity of physicalactivity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered and modi fid as necessary inindividual patients?. ### Response: The form and intensity of physicalactivity.


Instruction: What may still have important healthbenefits even if physical activity falls below targets pro-posed for the general population?

Output: physicalactivity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may still have important healthbenefits even if physical activity falls below targets pro-posed for the general population?. ### Response: physicalactivity.


Instruction: What type of diet has been shown to lower BP in the general population?

Output: heart-healthy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diet has been shown to lower BP in the general population?. ### Response: heart-healthy.


Instruction: What does the Work Group recognize about weight loss among those who are overweight or obese?

Output: several other lifestyle in-terventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Work Group recognize about weight loss among those who are overweight or obese?. ### Response: several other lifestyle in-terventions.


Instruction: What are RCTs to lower in the general population?

Output: BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are RCTs to lower in the general population?. ### Response: BP.


Instruction: What may also have BP-lowering benefits in patients with CKD?

Output: RCTs to lower BP in thegeneral population. These lifestyle interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may also have BP-lowering benefits in patients with CKD?. ### Response: RCTs to lower BP in thegeneral population. These lifestyle interventions.


Instruction: When can these lifestyle interventions be applied?

Output: safely and without side effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When can these lifestyle interventions be applied?. ### Response: safely and without side effects.


Instruction: What are the risks orbenefits of interventions on BP in CKD populations perseprecluded speci fic recommendations in this guideline?

Output: risks orbeneﬁts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the risks orbenefits of interventions on BP in CKD populations perseprecluded speci fic recommendations in this guideline?. ### Response: risks orbeneﬁts.


Instruction: Conduct clinical trials evaluating different dietary sodiumreduction strategies for prevention of clinical endpoints of critical importance forCKD?

Output: Research recommendations/C15

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Conduct clinical trials evaluating different dietary sodiumreduction strategies for prevention of clinical endpoints of critical importance forCKD?. ### Response: Research recommendations/C15.


Instruction: There are inconsistencies among the studies examining therelationship of what?

Output: dietary sodium intake

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There are inconsistencies among the studies examining therelationship of what?. ### Response: dietary sodium intake.


Instruction: What are there inconsistencies among the studies examining therelationship of dietary sodium intake with health outcomesin persons with diabetes?

Output: disease, and mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are there inconsistencies among the studies examining therelationship of dietary sodium intake with health outcomesin persons with diabetes?. ### Response: disease, and mortality.


Instruction: What is required to investigate the consistency of effects ofdietarysodium changes on healthbenefits and harms across different causes and severities of CKD?

Output: Additional research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is required to investigate the consistency of effects ofdietarysodium changes on healthbenefits and harms across different causes and severities of CKD?. ### Response: Additional research.


Instruction: What is unknown if there is a minimum dietary sodium level inCKD below which health risks are increased?

Output: It is unknown if there is a minimum dietary sodium level inCKD below which health risks are increased. Most of thesewww.kidney-international

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is unknown if there is a minimum dietary sodium level inCKD below which health risks are increased?. ### Response: It is unknown if there is a minimum dietary sodium level inCKD below which health risks are increased. Most of thesewww.kidney-international.


Instruction: What was the subfinding about discharge from HF clinic rated as low confidence?

Output: methodological concerns and being limited to two papers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the subfinding about discharge from HF clinic rated as low confidence?. ### Response: methodological concerns and being limited to two papers.


Instruction: Why was HF clinic rated low confidence?

Output: methodological concerns

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was HF clinic rated low confidence?. ### Response: methodological concerns.


Instruction: How many papers were limited to?

Output: two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many papers were limited to?. ### Response: two.


Instruction: What did the committee feel the subfinding agreed with?

Output: their experiences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee feel the subfinding agreed with?. ### Response: their experiences.


Instruction: What is a risk factor for atherosclerotic disease in severe hypertriglyceride-mia?

Output: atherogenic VLDL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for atherosclerotic disease in severe hypertriglyceride-mia?. ### Response: atherogenic VLDL.


Instruction: What are some of the other factors that contribute to the increased risk of ATHEROSCLERotic disease?

Output: obesity, metabolic syndrome, and hyperglycemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the other factors that contribute to the increased risk of ATHEROSCLERotic disease?. ### Response: obesity, metabolic syndrome, and hyperglycemia.


Instruction: Is chylomicronemia per se or per se?

Output: per se

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Is chylomicronemia per se or per se?. ### Response: per se.


Instruction: What does chylomicronemia associate with in most patients?

Output: other atherogenic factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does chylomicronemia associate with in most patients?. ### Response: other atherogenic factors.


Instruction: What type of therapy is reasonable?

Output: statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is reasonable?. ### Response: statin therapy.


Instruction: How can statins prevent increasing levels of triglycerides?

Output: statins alone cannot prevent increasing levels of triglycerides in the face of secondary causes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can statins prevent increasing levels of triglycerides?. ### Response: statins alone cannot prevent increasing levels of triglycerides in the face of secondary causes.


Instruction: What is a secondary cause of hypertriglyceridemic pancreatitis?

Output: increasing levels of triglycerides

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a secondary cause of hypertriglyceridemic pancreatitis?. ### Response: increasing levels of triglycerides.


Instruction: What is not part of the treatment regimen in a pregnant woman with severe hypertrichloride-mia because they are not recommended at the present time in pregnancy?

Output: statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not part of the treatment regimen in a pregnant woman with severe hypertrichloride-mia because they are not recommended at the present time in pregnancy?. ### Response: statins.


Instruction: What type of studies show that patients with moderate hypertriglyceridemia are generally at increased risk of ASCVD?

Output: Epidemiological

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of studies show that patients with moderate hypertriglyceridemia are generally at increased risk of ASCVD?. ### Response: Epidemiological.


Instruction: What does statin therapy reduce similarly to fibrates?

Output: VLDL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does statin therapy reduce similarly to fibrates?. ### Response: VLDL.


Instruction: Statin therapy reduces VLDL similarly to what?

Output: fibrates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Statin therapy reduces VLDL similarly to what?. ### Response: fibrates.


Instruction: Statin trials include hypertriglyc-eridemic patients?

Output: Statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Statin trials include hypertriglyc-eridemic patients?. ### Response: Statin therapy.


Instruction: There is evidence to show that what increases the patient’s ASCVD risk?

Output: VLDL excess

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is evidence to show that what increases the patient’s ASCVD risk?. ### Response: VLDL excess.


Instruction: What is hyper -triglyceridemia's major risk fac-tors for ASCVD?

Output: atherosclerotic disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hyper -triglyceridemia's major risk fac-tors for ASCVD?. ### Response: atherosclerotic disease.


Instruction: What is a 10-year risk of asCVD 7.5% by the PCE?

Output: moderate hyper -triglyceridemia has poorly controlled major risk fac-tors for ASCVD and a 10-year risk of ASCVD ≥7.5% by the PCE, it is reasonable to either initiate or inten-sify statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a 10-year risk of asCVD 7.5% by the PCE?. ### Response: moderate hyper -triglyceridemia has poorly controlled major risk fac-tors for ASCVD and a 10-year risk of ASCVD ≥7.5% by the PCE, it is reasonable to either initiate or inten-sify statin therapy.


Instruction: How is it reasonable to initiate or inten-sify statin therapy?

Output: if an adult patient with moderate hyper -triglyceridemia has poorly controlled major risk fac-tors for ASCVD and a 10-year risk of ASCVD ≥7.5% by the PCE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is it reasonable to initiate or inten-sify statin therapy?. ### Response: if an adult patient with moderate hyper -triglyceridemia has poorly controlled major risk fac-tors for ASCVD and a 10-year risk of ASCVD ≥7.5% by the PCE.


Instruction: What do most patients with triglycerides 500 mg/dL have elevations of?

Output: VLDL and chylo-microns

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do most patients with triglycerides 500 mg/dL have elevations of?. ### Response: VLDL and chylo-microns.


Instruction: What may cause acute pancreatitis?

Output: chylomicronemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may cause acute pancreatitis?. ### Response: chylomicronemia.


Instruction: How high is the risk of chylomicronemia?

Output: in most patients it associates with other atherogenic factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How high is the risk of chylomicronemia?. ### Response: in most patients it associates with other atherogenic factors.


Instruction: What is the risk of developing unrecognized marked increases in triglycerides?

Output: pan-creatitis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of developing unrecognized marked increases in triglycerides?. ### Response: pan-creatitis.


Instruction: What is a condition that can lead to pan-creatitis?

Output: hypertriglyceridemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a condition that can lead to pan-creatitis?. ### Response: hypertriglyceridemia.


Instruction: What may contribute to pancreatitis?

Output: chylomicronemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may contribute to pancreatitis?. ### Response: chylomicronemia.


Instruction: To prevent acute pancreattitis, it is reasonable to reduce triglycerides whenever levels exceed what?

Output: 500 mg/dL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: To prevent acute pancreattitis, it is reasonable to reduce triglycerides whenever levels exceed what?. ### Response: 500 mg/dL.


Instruction: What can be achieved by addressing and eliminating the underlying factors?

Output: reduce triglycerides

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be achieved by addressing and eliminating the underlying factors?. ### Response: reduce triglycerides.


Instruction: Hypertriglyceridemia (Continued)COR LOE RecommendationsDownloaded from http://ahajournals.org by what date?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hypertriglyceridemia (Continued)COR LOE RecommendationsDownloaded from http://ahajournals.org by what date?. ### Response: April 28, 2023.


Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al.


Instruction: What is the name of the guideline for management of valve heart disease?

Output: ACC/AHA Guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the guideline for management of valve heart disease?. ### Response: ACC/AHA Guideline.


Instruction: When did Otto and colleagues publish their guideline?

Output: February 2, 2021

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Otto and colleagues publish their guideline?. ### Response: February 2, 2021.


Instruction: What is the Italian Study on the Treat-ment of Ischemic Mitral Regurgitation?

Output: ISTIMIR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Italian Study on the Treat-ment of Ischemic Mitral Regurgitation?. ### Response: ISTIMIR.


Instruction: What is ISTIMIR?

Output: The Italian Study on the Treat-ment of Ischemic Mitral Regurgitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ISTIMIR?. ### Response: The Italian Study on the Treat-ment of Ischemic Mitral Regurgitation.


Instruction: When was the J Thorac Cardiovasc Surg. 145:128–39?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Thorac Cardiovasc Surg. 145:128–39?. ### Response: 2013.


Instruction: What year did Surg. 2004:128:916–24?

Output: 2004;128:916–24. 47. Miller DC. Ischemic mitral regurgitation redux–to repair or to replace? J Thorac Cardiovasc Surg. 2001

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Surg. 2004:128:916–24?. ### Response: 2004;128:916–24. 47. Miller DC. Ischemic mitral regurgitation redux–to repair or to replace? J Thorac Cardiovasc Surg. 2001.


Instruction: What is the purpose of Ischemic mitral regurgitation redux?

Output: to repair or to replace

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of Ischemic mitral regurgitation redux?. ### Response: to repair or to replace.


Instruction: When was J Thorac Cardiovasc Surg 122:1059–62?

Output: 2001

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was J Thorac Cardiovasc Surg 122:1059–62?. ### Response: 2001.


Instruction: How did Grayburn PA, Foster E, Sangli C, et al. study the relationship between the mag-nitude of reduction in mitral reurgitation severity and left ventricular and left atrial reverse remodeling?

Output: MitraClip therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Grayburn PA, Foster E, Sangli C, et al. study the relationship between the mag-nitude of reduction in mitral reurgitation severity and left ventricular and left atrial reverse remodeling?. ### Response: MitraClip therapy.


Instruction: What did MitraClip therapy do for left atrial reverse remodeling?

Output: reduction in mitral regurgitation severity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did MitraClip therapy do for left atrial reverse remodeling?. ### Response: reduction in mitral regurgitation severity.


Instruction: What is the difference between MITRA-FR and COAPT?

Output: diametrically opposed results

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between MITRA-FR and COAPT?. ### Response: diametrically opposed results.


Instruction: How many tri-als did Pibarot P, Delgado V, Bax JJ have?

Output: 49

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many tri-als did Pibarot P, Delgado V, Bax JJ have?. ### Response: 49.


Instruction: What predicts reverse remodeling following restrictive mitral annuloplasty in isch-emic mitral regurgitation?

Output: Preoperative left ventricular dimensions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What predicts reverse remodeling following restrictive mitral annuloplasty in isch-emic mitral regurgitation?. ### Response: Preoperative left ventricular dimensions.


Instruction: What does Eur J Cardiothorac Surg. 2005 27:847-53?

Output: ricular dimensions predict reverse remodeling following restrictive mitral annuloplasty in isch-emic mitral regurgitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Eur J Cardiothorac Surg. 2005 27:847-53?. ### Response: ricular dimensions predict reverse remodeling following restrictive mitral annuloplasty in isch-emic mitral regurgitation.


Instruction: Atrial functional mitral regurgita-tion: JACC review topic of the week.

Output: Mitral valve adaptation to isolated annular dilation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atrial functional mitral regurgita-tion: JACC review topic of the week.. ### Response: Mitral valve adaptation to isolated annular dilation.


Instruction: What is evidence of atrial functional mitral re-gurgitation due to atrial fibrillation?

Output: reversal with arrhythmia control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is evidence of atrial functional mitral re-gurgitation due to atrial fibrillation?. ### Response: reversal with arrhythmia control.


Instruction: What is the effect of tricuspid regurgitation on long-term survival?

Output: Excess mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of tricuspid regurgitation on long-term survival?. ### Response: Excess mortality.


Instruction: What is the impact of tricuspid regurgitation on long-term survival?

Output: 405–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact of tricuspid regurgitation on long-term survival?. ### Response: 405–.


Instruction: When did J Am Coll Cardiol.43:405–9 release?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J Am Coll Cardiol.43:405–9 release?. ### Response: 2004.


Instruction: What was the clinical outcome of isolated tricu-pid re-gurgitation?

Output: preserved left ventricular ejection fraction and pulmonary hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the clinical outcome of isolated tricu-pid re-gurgitation?. ### Response: preserved left ventricular ejection fraction and pulmonary hypertension.


Instruction: How did Lee J-W, Song J-M, Park JP, et al. compare to other types of regurgitations?

Output: Long-term prognosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Lee J-W, Song J-M, Park JP, et al. compare to other types of regurgitations?. ### Response: Long-term prognosis.


Instruction: What is the long-term prognosis of isolated signifi-cant tricuspid regurgitation?

Output: Clinical outcome of isolated tricuspid regurgitation in patients with preserved left ventricular ejection fraction and pulmonary hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the long-term prognosis of isolated signifi-cant tricuspid regurgitation?. ### Response: Clinical outcome of isolated tricuspid regurgitation in patients with preserved left ventricular ejection fraction and pulmonary hypertension.


Instruction: What was the Circ J. 2010:74:375–80?

Output: Long-term prognosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the Circ J. 2010:74:375–80?. ### Response: Long-term prognosis.


Instruction: Bar N, Schwartz LA, Biner S, et al. Clinical outcome of what in patients with preserved left ventricular ejection fraction and pulmonary hypertension?

Output: isolated tricuspid regurgitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Bar N, Schwartz LA, Biner S, et al. Clinical outcome of what in patients with preserved left ventricular ejection fraction and pulmonary hypertension?. ### Response: isolated tricuspid regurgitation.


Instruction: What is tricuspid regurgitation associated with?

Output: long-term survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is tricuspid regurgitation associated with?. ### Response: long-term survival.


Instruction: What is the cause of heart failure with reduced ejection fraction?

Output: Excess mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cause of heart failure with reduced ejection fraction?. ### Response: Excess mortality.


Instruction: What is the grade 2C of LMWH?

Output: one-quarter to one-third

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the grade 2C of LMWH?. ### Response: one-quarter to one-third.


Instruction: What should prompt reevaluation of whether there was a recurrent VTE?

Output: Recurrent VTE while on therapeutic-doseanticoagulant therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should prompt reevaluation of whether there was a recurrent VTE?. ### Response: Recurrent VTE while on therapeutic-doseanticoagulant therapy.


Instruction: How long is a temporary switch to LMWH usually for?

Output: 1 month

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is a temporary switch to LMWH usually for?. ### Response: 1 month.


Instruction: How long does it usually take for patients who have recurrent VTE to switch toLMWH?

Output: 1 month

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it usually take for patients who have recurrent VTE to switch toLMWH?. ### Response: 1 month.


Instruction: What do we suggest in patients who are believed to be compliant?

Output: increasing the dose of LMWH by aboutone-quarter to one-third

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do we suggest in patients who are believed to be compliant?. ### Response: increasing the dose of LMWH by aboutone-quarter to one-third.


Instruction: What do we suggest increasing the dose of LMWH by about one-quarter to one-third (Grade 2C)?

Output: In patients who have recurrent VTE on long-term LMWH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do we suggest increasing the dose of LMWH by about one-quarter to one-third (Grade 2C)?. ### Response: In patients who have recurrent VTE on long-term LMWH.


Instruction: Recurrent VTE while on therapeutic-doseanticoagulant therapy is unusual and should prompt what?

Output: thefollowing assessments

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Recurrent VTE while on therapeutic-doseanticoagulant therapy is unusual and should prompt what?. ### Response: thefollowing assessments.


Instruction: What is the ACCF/AHA CABG Guideline e711Downloaded from http://ahajournals.org by on April 26, 2023?

Output: Hillis et al 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ACCF/AHA CABG Guideline e711Downloaded from http://ahajournals.org by on April 26, 2023?. ### Response: Hillis et al 2011.


Instruction: What are the outcomes of percutaneous coronary intervention with drug-eluting stents for patients with multivessel coronary artery disease?

Output: coronary arterybypass grafting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the outcomes of percutaneous coronary intervention with drug-eluting stents for patients with multivessel coronary artery disease?. ### Response: coronary arterybypass grafting.


Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al.


Instruction: What is the DOI for the February 2, 2021 e213CLINICAL STATEMENTS AND GUIDELINES 9. Prendergast BD. Diagnostic criteria and problems in infective endocarditis. 2004;90:611–3.

Output: 10.1161/CIR.0000000000000923

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the DOI for the February 2, 2021 e213CLINICAL STATEMENTS AND GUIDELINES 9. Prendergast BD. Diagnostic criteria and problems in infective endocarditis. 2004;90:611–3.. ### Response: 10.1161/CIR.0000000000000923.


Instruction: What criteria is used in patients with sus-pected infective endocarditis and negative transesophageal echocardio-grams?

Output: Duke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What criteria is used in patients with sus-pected infective endocarditis and negative transesophageal echocardio-grams?. ### Response: Duke.


Instruction: What is the name of the study that studies the clinical presentation, etiology, and outcome of infected endeocarditic disease in the 21st century?

Output: International Collaboration on Endocarditis-Prospective Cohort Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that studies the clinical presentation, etiology, and outcome of infected endeocarditic disease in the 21st century?. ### Response: International Collaboration on Endocarditis-Prospective Cohort Study.


Instruction: What is the International Collaboration on Endocarditis-Prospective Cohort Study?

Output: Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the International Collaboration on Endocarditis-Prospective Cohort Study?. ### Response: Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century.


Instruction: What year did Arch Intern Med publish 169:463–73?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Arch Intern Med publish 169:463–73?. ### Response: 2009.


Instruction: How did Haldar SM, O’Gara PT diagnose and manage infective endocardiitis?

Output: diagnosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Haldar SM, O’Gara PT diagnose and manage infective endocardiitis?. ### Response: diagnosis.


Instruction: Infective endocarditis. 2006;31:274–352. 14. Mügge A, Daniel WG, Frank G, et al. Echocardiography in what?

Output: infective endo-carditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Infective endocarditis. 2006;31:274–352. 14. Mügge A, Daniel WG, Frank G, et al. Echocardiography in what?. ### Response: infective endo-carditis.


Instruction: What approach is used to assess prognostic implications of vegetation size deter?

Output: transthoracic versus transesophageal echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What approach is used to assess prognostic implications of vegetation size deter?. ### Response: transthoracic versus transesophageal echocardiography.


Instruction: What is the role of two-dimensional echocar -diology in the diagnosis of infective endocarditis?

Output: corrected

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of two-dimensional echocar -diology in the diagnosis of infective endocarditis?. ### Response: corrected.


Instruction: What does a negative transthoracic echocardiogram obviates the need for?

Output: transesophageal echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does a negative transthoracic echocardiogram obviates the need for?. ### Response: transesophageal echocardiography.


Instruction: What type of echocardiography is used in patients with suspected native valve active infective endocarditis?

Output: Duke criteria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of echocardiography is used in patients with suspected native valve active infective endocarditis?. ### Response: Duke criteria.


Instruction: What is the name of the study that evaluated the use of transthoracic echocardiog-raphy?

Output: infective endocarditis screening

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated the use of transthoracic echocardiog-raphy?. ### Response: infective endocarditis screening.


Instruction: In what year did Can J Cardiol. 2009:25:703-5?

Output: 1991

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did Can J Cardiol. 2009:25:703-5?. ### Response: 1991.


Instruction: How does echocardiography diagnose culture-negative endocarditis?

Output: screen-ing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does echocardiography diagnose culture-negative endocarditis?. ### Response: screen-ing.


Instruction: What is the name of the study that focuses on infective endocar -ditis in South Med J?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that focuses on infective endocar -ditis in South Med J?. ### Response: 1999.


Instruction: How is the use of echocardiog-raphy used in the diagnosis of infection?

Output: Judicious

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the use of echocardiog-raphy used in the diagnosis of infection?. ### Response: Judicious.


Instruction: When was the Circulation. 1981?

Output: 1981;64:641–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circulation. 1981?. ### Response: 1981;64:641–.


Instruction: What does transesophageal echocardiog-raphy do in diagnosis of infective endocarditis?

Output: reassessment of prognostic implications of vegetation size

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does transesophageal echocardiog-raphy do in diagnosis of infective endocarditis?. ### Response: reassessment of prognostic implications of vegetation size.


Instruction: When was the Chest 105:377-82 published?

Output: 1994

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Chest 105:377-82 published?. ### Response: 1994.


Instruction: What did Erbel R, Rohmann S, Drexler M, et al. say improved diagnostic value of echo-cardiography in patients with infectious endo cardiotis by?

Output: transoesophageal approach

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Erbel R, Rohmann S, Drexler M, et al. say improved diagnostic value of echo-cardiography in patients with infectious endo cardiotis by?. ### Response: transoesophageal approach.


Instruction: What is the prevalence of infective endocarditis in patients with Staphylococcus aureus bacteraemia?

Output: Prevalence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the prevalence of infective endocarditis in patients with Staphylococcus aureus bacteraemia?. ### Response: Prevalence.


Instruction: When did Eur J Echocardiogr. 2011:12:414–20?

Output: 23

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Eur J Echocardiogr. 2011:12:414–20?. ### Response: 23.


Instruction: What is sensitivity of transthoracic versus transesophageal echocardiography for?

Output: the detection of native valve veg-etations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is sensitivity of transthoracic versus transesophageal echocardiography for?. ### Response: the detection of native valve veg-etations.


Instruction: Transthoracic versus transesophageal echocardiography for the detection of native valve veg-etations in the modern era?

Output: Sensitivity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Transthoracic versus transesophageal echocardiography for the detection of native valve veg-etations in the modern era?. ### Response: Sensitivity.


Instruction: J Am Soc Echocardiogr. 2003;16:67-70.

Output: 23. Reynolds HR, Jagen MA, Tunick PA, et al. Sensitivity of transthoracic versus transesophageal echocardiography for the detection of native valve veg-etations in the modern era. J Am Soc Echocardiogr. 2003;16:67–70. 24

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: J Am Soc Echocardiogr. 2003;16:67-70.. ### Response: 23. Reynolds HR, Jagen MA, Tunick PA, et al. Sensitivity of transthoracic versus transesophageal echocardiography for the detection of native valve veg-etations in the modern era. J Am Soc Echocardiogr. 2003;16:67–70. 24.


Instruction: What is the lifetime risk of stroke: estimates from the Framingham Study?

Output: 345–350

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the lifetime risk of stroke: estimates from the Framingham Study?. ### Response: 345–350.


Instruction: How many strokes were there in England and Wales in 2003?

Output: 34:1598–1602

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes were there in England and Wales in 2003?. ### Response: 34:1598–1602.


Instruction: What was the name of the study that estimated the lifetime stroke risk?

Output: Framingham Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the study that estimated the lifetime stroke risk?. ### Response: Framingham Study.


Instruction: What is a risk factor for hypertension?

Output: Low birth weight

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for hypertension?. ### Response: Low birth weight.


Instruction: What is the name of the national longitudinal population-based study of the United States?

Output: Early-life origins of adult disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the national longitudinal population-based study of the United States?. ### Response: Early-life origins of adult disease.


Instruction: What is the name of the study that examined the impact of race and nativity on death in the “Stroke Belt”?

Output: Hypertension. 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined the impact of race and nativity on death in the “Stroke Belt”?. ### Response: Hypertension. 1999.


Instruction: What was the name given to the study in 1999?

Output: Northern Manhattan Stroke Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name given to the study in 1999?. ### Response: Northern Manhattan Stroke Study.


Instruction: Who was the author of this study?

Output: Johnson RC, Schoeni RF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the author of this study?. ### Response: Johnson RC, Schoeni RF.


Instruction: In what year was this study published?

Output: 1994

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was this study published?. ### Response: 1994.


Instruction: What is the name of the group that represents the American Heart Association Stroke Council?

Output: Council on Cardiovascular Nursing; Council on Epidemiology and Prevention; Council on Quality of Care and Outcomes Research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that represents the American Heart Association Stroke Council?. ### Response: Council on Cardiovascular Nursing; Council on Epidemiology and Prevention; Council on Quality of Care and Outcomes Research.


Instruction: What does the Council on Epidemiology and Prevention represent?

Output: American Heart Association Stroke Council

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Council on Epidemiology and Prevention represent?. ### Response: American Heart Association Stroke Council.


Instruction: Racial-ethnic disparities in stroke care: the American experi-ence: a statement for healthcare professionals from what association?

Output: American Heart Association/American Stroke Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Racial-ethnic disparities in stroke care: the American experi-ence: a statement for healthcare professionals from what association?. ### Response: American Heart Association/American Stroke Association.


Instruction: Stroke. 2011;42:2091–2116.

Output: 36

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Stroke. 2011;42:2091–2116.. ### Response: 36.


Instruction: What is the excess burden of stroke among blacks?

Output: Stroke in a biracial population

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the excess burden of stroke among blacks?. ### Response: Stroke in a biracial population.


Instruction: When did Stroke in a biracial population occur?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Stroke in a biracial population occur?. ### Response: 2004.


Instruction: How many strokes were there in 2004?

Output: 426–431

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes were there in 2004?. ### Response: 426–431.


Instruction: What was the unchang-ing incidence and case-fatality of stroke in the 1990s: a population-based study?

Output: Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the unchang-ing incidence and case-fatality of stroke in the 1990s: a population-based study?. ### Response: Stroke.


Instruction: Stroke. 2006;37:2473–2478.

Output: 38

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Stroke. 2006;37:2473–2478.. ### Response: 38.


Instruction: What is the stroke incidence among white, black, and Hispanic residents of an urban area?

Output: Racial-ethnic disparities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the stroke incidence among white, black, and Hispanic residents of an urban area?. ### Response: Racial-ethnic disparities.


Instruction: What was the Northern Manhattan Stroke Study?

Output: Stroke incidence among white, black, and Hispanic residents of an urban community

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the Northern Manhattan Stroke Study?. ### Response: Stroke incidence among white, black, and Hispanic residents of an urban community.


Instruction: When was the Am J Epidemiol 147:259–268 published?

Output: 1998

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Am J Epidemiol 147:259–268 published?. ### Response: 1998.


Instruction: What is the national longitudinal measure of stroke mortality?

Output: The National Longitudinal Mortality Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the national longitudinal measure of stroke mortality?. ### Response: The National Longitudinal Mortality Study.


Instruction: What is the difference between non-Hispanic whites, Hispanic whites and blacks?

Output: Ethnic differences in stroke mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between non-Hispanic whites, Hispanic whites and blacks?. ### Response: Ethnic differences in stroke mortality.


Instruction: The National Longitudinal Mortality Study. Stroke. 1994;25:2120–2125.

Output: 40

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The National Longitudinal Mortality Study. Stroke. 1994;25:2120–2125.. ### Response: 40.


Instruction: What is the brain attack surveillance in Corpus Christi project?

Output: Excess stroke in Mexican Americans compared with non-Hispanic Whites

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the brain attack surveillance in Corpus Christi project?. ### Response: Excess stroke in Mexican Americans compared with non-Hispanic Whites.


Instruction: What are the differences in intra-cerebral hemorrhage between Mexican Americans and non-Hispanic Whites?

Output: Ethnic differences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the differences in intra-cerebral hemorrhage between Mexican Americans and non-Hispanic Whites?. ### Response: Ethnic differences.


Instruction: What is the difference between Mexican Americans and non-Hispanic whites in intracerebral hemorrhage?

Output: Excess stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between Mexican Americans and non-Hispanic whites in intracerebral hemorrhage?. ### Response: Excess stroke.


Instruction: What should VKAs Rather Than Aspirin Plus Clopidogrel Be Used in Patients With AF?

Output: Antithrombotic Therapy for Atrial Fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should VKAs Rather Than Aspirin Plus Clopidogrel Be Used in Patients With AF?. ### Response: Antithrombotic Therapy for Atrial Fibrillation.


Instruction: What is the relative effect 95% CI?

Output: Study Event Rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the relative effect 95% CI?. ### Response: Study Event Rates.


Instruction: What is the median follow-up for ASA 1 Clopid With VKA?

Output: 1.3 y1 RCT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the median follow-up for ASA 1 Clopid With VKA?. ### Response: 1.3 y1 RCT.


Instruction: What percentage of the time frame is used to estimate Absolute Effects?

Output: 95% CI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the time frame is used to estimate Absolute Effects?. ### Response: 95% CI.


Instruction: What was the median follow-up for ischemic stroke and intracranial hemorrhage?

Output: 1.3 y

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the median follow-up for ischemic stroke and intracranial hemorrhage?. ### Response: 1.3 y.


Instruction: What is the RR of 158/3,371?

Output: 0.98 (0.79-1.22)46 per 1,000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the RR of 158/3,371?. ### Response: 0.98 (0.79-1.22)46 per 1,000.


Instruction: How long did it take to diagnose ischemic stroke and intracranial hemorrhage?

Output: 3 y

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take to diagnose ischemic stroke and intracranial hemorrhage?. ### Response: 3 y.


Instruction: How many points did CHADS score?

Output: 0

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many points did CHADS score?. ### Response: 0.


Instruction: How many points are High5 per 1,000?

Output: 2  0

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many points are High5 per 1,000?. ### Response: 2  0.


Instruction: How many fewer strokes per 1,000 (from 1 fewer to 3 fewer)?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many fewer strokes per 1,000 (from 1 fewer to 3 fewer)?. ### Response: 2.


Instruction: What is the median follow-up for nonfatal major extracranial bleeds?

Output: 1.3 y  h  1 RCT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the median follow-up for nonfatal major extracranial bleeds?. ### Response: 1.3 y  h  1 RCT.


Instruction: How many fewer strokes per 1,000 (from 5 fewer to 16 fewer) are there?

Output: 11

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many fewer strokes per 1,000 (from 5 fewer to 16 fewer) are there?. ### Response: 11.


Instruction: What percentage of patients were receiving VKA at study entry?

Output: 77%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients were receiving VKA at study entry?. ### Response: 77%.


Instruction: How many fewer bleeds per 1,000 were there?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many fewer bleeds per 1,000 were there?. ### Response: 1.


Instruction: How many fewer bleeds per 1,000?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many fewer bleeds per 1,000?. ### Response: 1.


Instruction: What is the name of the American College of Chest Physicians?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the American College of Chest Physicians?. ### Response: 2012.


Instruction: Who wrote the article chestjournal.chestpubs.org?

Output: Kimberly Henricks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote the article chestjournal.chestpubs.org?. ### Response: Kimberly Henricks.


Instruction: What is a risk model from the ACUITY trial?

Output: Associations of major bleeding and myocardial infarction with the incidence and timing of mortality in patients presenting with non-ST-elevation acute coronary syndromes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk model from the ACUITY trial?. ### Response: Associations of major bleeding and myocardial infarction with the incidence and timing of mortality in patients presenting with non-ST-elevation acute coronary syndromes.


Instruction: What is an association between major bleeding and myocardial infarction with the incidence and timing of mortality in non-ST-elevation acute coronary syndromes?

Output: blood transfusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an association between major bleeding and myocardial infarction with the incidence and timing of mortality in non-ST-elevation acute coronary syndromes?. ### Response: blood transfusion.


Instruction: What is the name of the journal that describes the variation in the definitions of bleeding in clinical trials of patients with acute coronary syndromes and undergoing percutaneous coronary interventions and its impact on the apparent safety of antithrombotic drugs?

Output: Am Heart J.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that describes the variation in the definitions of bleeding in clinical trials of patients with acute coronary syndromes and undergoing percutaneous coronary interventions and its impact on the apparent safety of antithrombotic drugs?. ### Response: Am Heart J..


Instruction: Steinhubl SR, Kastrati A, Berger PB. Assessing the safety of what?

Output: antithrombotic drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Steinhubl SR, Kastrati A, Berger PB. Assessing the safety of what?. ### Response: antithrombotic drugs.


Instruction: What is the definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients?

Output: Schulman S, Kearon C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients?. ### Response: Schulman S, Kearon C.


Instruction: What is Rao SV's title?

Output: 722

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Rao SV's title?. ### Response: 722.


Instruction: What is a common cause of bleeding and blood transfusion issues in non-ST-segment elevation acute coronary syndromes?

Output: myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a common cause of bleeding and blood transfusion issues in non-ST-segment elevation acute coronary syndromes?. ### Response: myocardial infarction.


Instruction: What is the name of the journal that describes non-surgical patients?

Output: Am J Cardiol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that describes non-surgical patients?. ### Response: Am J Cardiol.


Instruction: What is heparin used for in ST-segment elevation myocardial infarction?

Output: primary angioplasty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is heparin used for in ST-segment elevation myocardial infarction?. ### Response: primary angioplasty.


Instruction: What is Campbell CL, Steinhubl SR, Hooper WC, et al. associated with in acute coro-nary syndromes?

Output: Bleeding events are associated with an increase in markers of inflammation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Campbell CL, Steinhubl SR, Hooper WC, et al. associated with in acute coro-nary syndromes?. ### Response: Bleeding events are associated with an increase in markers of inflammation.


Instruction: What is an ACUITY trial substudy?

Output: markers of inflammation in acute coro-nary syndromes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an ACUITY trial substudy?. ### Response: markers of inflammation in acute coro-nary syndromes.


Instruction: What is the baseline risk of major bleeding in non-ST-segment-elevation myocardial infarction?

Output: CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA Guidelines) Bleeding Score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the baseline risk of major bleeding in non-ST-segment-elevation myocardial infarction?. ### Response: CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA Guidelines) Bleeding Score.


Instruction: What did ADverse outcomes with Early implementation of the ACC/AHA Guidelines do?

Output: Suppress

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did ADverse outcomes with Early implementation of the ACC/AHA Guidelines do?. ### Response: Suppress.


Instruction: What was the Bleeding Score?

Output: CRUSADE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the Bleeding Score?. ### Response: CRUSADE.


Instruction: When did Circulation. 2009:119:1873-82.

Output: 726

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circulation. 2009:119:1873-82.. ### Response: 726.


Instruction: What did Chatterjee S, Wetterslev J, Sharma A, et al. association of blood transfusion with increased mortality in myocardial infarction?

Output: a meta-analysis and diver -sity-adjusted study sequential analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Chatterjee S, Wetterslev J, Sharma A, et al. association of blood transfusion with increased mortality in myocardial infarction?. ### Response: a meta-analysis and diver -sity-adjusted study sequential analysis.


Instruction: What is the name of the journal that published guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes?

Output: JAMA Intern Med.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that published guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes?. ### Response: JAMA Intern Med..


Instruction: When did Eur Heart J. 2007:28:1598-660?

Output: 728

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Eur Heart J. 2007:28:1598-660?. ### Response: 728.


Instruction: What is thrombocytopenia in patients treated with prolonged heparin?

Output: Incidence and prognostic sig-nificance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is thrombocytopenia in patients treated with prolonged heparin?. ### Response: Incidence and prognostic sig-nificance.


Instruction: What is the prognostic significance of thrombocytopenia in patients treated with prolonged heparin therapy?

Output: Incidence and prognostic sig-nificance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the prognostic significance of thrombocytopenia in patients treated with prolonged heparin therapy?. ### Response: Incidence and prognostic sig-nificance.


Instruction: What is Wang TY, Ou FS, Roe MT, et al. Incidence and prost-nificance of what developed during acute coronary syndrome in contemporary clinical practice?

Output: thrombocytopenia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Wang TY, Ou FS, Roe MT, et al. Incidence and prost-nificance of what developed during acute coronary syndrome in contemporary clinical practice?. ### Response: thrombocytopenia.


Instruction: Circulation. 2009;119:2454–62.

Output: 730

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation. 2009;119:2454–62.. ### Response: 730.


Instruction: Circulation. 2009;119:2454–62. 730. Hakim DA, Dangas GD, Caixeta A, et al. Impact of baseline thrombocyto-penia on the early and late outcomes after what treatment?

Output: ST-elevation myocardial infarc-tion treated with primary angioplasty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation. 2009;119:2454–62. 730. Hakim DA, Dangas GD, Caixeta A, et al. Impact of baseline thrombocyto-penia on the early and late outcomes after what treatment?. ### Response: ST-elevation myocardial infarc-tion treated with primary angioplasty.


Instruction: Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) trial. 2011;161:391–6.

Output: Am Heart

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) trial. 2011;161:391–6.. ### Response: Am Heart.


Instruction: What is the name of the book that treats heart failure chronic heart failure?

Output: NICE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the book that treats heart failure chronic heart failure?. ### Response: NICE.


Instruction: Who is the author of NICE 2018?

Output: 978

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of NICE 2018?. ### Response: 978.


Instruction: How many studies were LOWb due to risk of bias (0.32 to 0.94)?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were LOWb due to risk of bias (0.32 to 0.94)?. ### Response: 2.


Instruction: How many fewer studies were conducted per 1 000?

Output: 70

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many fewer studies were conducted per 1 000?. ### Response: 70.


Instruction: How many fewer deaths per 1000?

Output: 55

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many fewer deaths per 1000?. ### Response: 55.


Instruction: How many deaths per 1 000?

Output: 39 fewer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many deaths per 1 000?. ### Response: 39 fewer.


Instruction: What is the CKD class 3 -4 704?

Output: Hospitalisation for cardiovascular disorder

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the CKD class 3 -4 704?. ### Response: Hospitalisation for cardiovascular disorder.


Instruction: What is the HR of CKD class 3a 669?

Output: 0.76

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the HR of CKD class 3a 669?. ### Response: 0.76.


Instruction: Why is the risk of bias VERY low?

Output: imprecision

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is the risk of bias VERY low?. ### Response: imprecision.


Instruction: How long does it take to die or be hospitalised?

Output: 1.3 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take to die or be hospitalised?. ### Response: 1.3 years.


Instruction: Why is HR VERY LOWb,c,e due to risk of bias, indirectness, imprecision?

Output: risk of bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is HR VERY LOWb,c,e due to risk of bias, indirectness, imprecision?. ### Response: risk of bias.


Instruction: What is HR 0.72 (0.57 to 0.91)?

Output: imprecision

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is HR 0.72 (0.57 to 0.91)?. ### Response: imprecision.


Instruction: How many deaths or hospitalisations are there for CKD class 3b?

Output: 235

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many deaths or hospitalisations are there for CKD class 3b?. ### Response: 235.


Instruction: How long did a CKD class 3b -4 235 last?

Output: 1.3 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did a CKD class 3b -4 235 last?. ### Response: 1.3 years.


Instruction: Why was the HR VERY LOWb,c,e?

Output: risk  of bias, imprecision

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the HR VERY LOWb,c,e?. ### Response: risk  of bias, imprecision.


Instruction: What is the risk of bias, indirectness, imprecision?

Output: VERY LOWb

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of bias, indirectness, imprecision?. ### Response: VERY LOWb.


Instruction: How many hospitalisations per 1000?

Output: 553

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many hospitalisations per 1000?. ### Response: 553.


Instruction: How many studies did CKD class 3a 870 (1 study) 1 year  VERY LOWb,c due to risk of bias, imprecision HR 0.9 (0.73 to 1.11) 374 per 1000 30 fewer per 1000

Output: -4 341

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies did CKD class 3a 870 (1 study) 1 year  VERY LOWb,c due to risk of bias, imprecision HR 0.9 (0.73 to 1.11) 374 per 1000 30 fewer per 1000. ### Response: -4 341.


Instruction: How many studies did a CKD class 3b -4 341 do?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies did a CKD class 3b -4 341 do?. ### Response: 1.


Instruction: Why was the risk of bias VERY LOW?

Output: imprecision

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the risk of bias VERY LOW?. ### Response: imprecision.


Instruction: What was the imprecision HR of the study?

Output: 0.61

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the imprecision HR of the study?. ### Response: 0.61.


Instruction: What is the risk of bias, imprecision HR 0.61 (0.47 to 0.79) 883 per 1000 153 fewer per 10 00 (from 67 fewer to 248 fewer) Hospitalisation for cardiovascular disorder - CKD class 3 -4 704 (1 study) 1.8 years  VERY lowb,c,f due to what?

Output: LOWb,c

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of bias, imprecision HR 0.61 (0.47 to 0.79) 883 per 1000 153 fewer per 10 00 (from 67 fewer to 248 fewer) Hospitalisation for cardiovascular disorder - CKD class 3 -4 704 (1 study) 1.8 years  VERY lowb,c,f due to what?. ### Response: LOWb,c.


Instruction: Why is 1.8 years  VERY LOWb,c,f due to risk of bias?

Output: imprecision

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is 1.8 years  VERY LOWb,c,f due to risk of bias?. ### Response: imprecision.


Instruction: What is HR 0.93?

Output: 0.7 to 1.24

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is HR 0.93?. ### Response: 0.7 to 1.24.


Instruction: How many fewer per 1000?

Output: 55

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many fewer per 1000?. ### Response: 55.


Instruction: What percentage of ACEi and ARB reduced major CV events to the same degree compared to placebo?

Output: 18%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of ACEi and ARB reduced major CV events to the same degree compared to placebo?. ### Response: 18%.


Instruction: What is suggested as t he first -line option?

Output: pregnancy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is suggested as t he first -line option?. ### Response: pregnancy.


Instruction: What is suggest ed as the third option as it ma y lead to mor e side eff ectiv e?

Output: hyldopa

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is suggest ed as the third option as it ma y lead to mor e side eff ectiv e?. ### Response: hyldopa.


Instruction: Met hyldopa is what?

Output: third option

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Met hyldopa is what?. ### Response: third option.


Instruction: What was the least eff ective option of t he 3?

Output: hyldopa

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the least eff ective option of t he 3?. ### Response: hyldopa.


Instruction: What was limit ed evidence on on t the benefit s and harms of planned early bir th compared with expectant management of pre-eclampsia?

Output: best place of car e for women wit h pre-eclampsia and t heir babies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was limit ed evidence on on t the benefit s and harms of planned early bir th compared with expectant management of pre-eclampsia?. ### Response: best place of car e for women wit h pre-eclampsia and t heir babies.


Instruction: In w omen wit h pre-eclampsia, why should decisions about timing of bir th be based on wh et the oman and bab y are at risk of adv erse out comes if pr egnancy is pr olonged?

Output: whet her

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In w omen wit h pre-eclampsia, why should decisions about timing of bir th be based on wh et the oman and bab y are at risk of adv erse out comes if pr egnancy is pr olonged?. ### Response: whet her.


Instruction: What are the recommendations based on?

Output: t hose fr om t he pr evious guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the recommendations based on?. ### Response: t hose fr om t he pr evious guideline.


Instruction: What is t he data fr om?

Output: HYPIT AT-II study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is t he data fr om?. ### Response: HYPIT AT-II study.


Instruction: Int ernational guidelines are used in what?

Output: clinical practice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Int ernational guidelines are used in what?. ### Response: clinical practice.


Instruction: What did the HYPIT AT-II study show about pre-eclampsia?

Output: pr egnancies in women wit h pre-eclampsia could be managed wit h continued sur veillance t o 37 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the HYPIT AT-II study show about pre-eclampsia?. ### Response: pr egnancies in women wit h pre-eclampsia could be managed wit h continued sur veillance t o 37 weeks.


Instruction: How long did it take for women to continue to have a pregnancy?

Output: 37 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for women to continue to have a pregnancy?. ### Response: 37 weeks.


Instruction: What was the duration of the study?

Output: 37 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the duration of the study?. ### Response: 37 weeks.


Instruction: What was the best place of car for women wit h pre-eclampsia and t heir babies?

Output: hyldopa

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the best place of car for women wit h pre-eclampsia and t heir babies?. ### Response: hyldopa.


Instruction: Pre-eclampsia and their babies, so t he committ ee made a resear ch recommendation?

Output: decisions about timing of bir th should be based on whet her the w oman and bab y are at risk of adv erse out comes if pr egnancy is pr olonged

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Pre-eclampsia and their babies, so t he committ ee made a resear ch recommendation?. ### Response: decisions about timing of bir th should be based on whet her the w oman and bab y are at risk of adv erse out comes if pr egnancy is pr olonged.


Instruction: How the r ecommendations mig ht affect practice?

Output: cause a significant change in practice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How the r ecommendations mig ht affect practice?. ### Response: cause a significant change in practice.


Instruction: What ar e in line wit h current best clinical practice so ar unlik ely to cause a significant change?

Output: r ecommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What ar e in line wit h current best clinical practice so ar unlik ely to cause a significant change?. ### Response: r ecommendations.


Instruction: What do some units admit all women with pre-eclampsia?

Output: some only admit women who t hey belie ve to be at a high risk of complications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do some units admit all women with pre-eclampsia?. ### Response: some only admit women who t hey belie ve to be at a high risk of complications.


Instruction: What are some units only admit women who belie ve to be at a high risk of?

Output: complications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some units only admit women who belie ve to be at a high risk of?. ### Response: complications.


Instruction: What is the risk of complications?

Output: high

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of complications?. ### Response: high.


Instruction: What could t herefore incr ease or r educe t he number of w omen who will be admitted?

Output: Standar dising practice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could t herefore incr ease or r educe t he number of w omen who will be admitted?. ### Response: Standar dising practice.


Instruction: What is lik ely to reduce unwant ed variance betw een unit s?

Output: Standar dising practice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is lik ely to reduce unwant ed variance betw een unit s?. ### Response: Standar dising practice.


Instruction: Full details of t he evidence ar e in evidence r eview D: interventions f or pr e-eclampsia?

Output: pr egnancy in w omen wit h pre-eclampsia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Full details of t he evidence ar e in evidence r eview D: interventions f or pr e-eclampsia?. ### Response: pr egnancy in w omen wit h pre-eclampsia.


Instruction: What is Hyper tension in pregnancy: diagnosis and management?

Output: NG133

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Hyper tension in pregnancy: diagnosis and management?. ### Response: NG133.


Instruction: When was the last updat ed?

Output: 17 April 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last updat ed?. ### Response: 17 April 2023.


Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart DiseaseFebruary 2, 2021 Circulation. 2021;143:e72–e227. DOI: 10.1161/CIR.0000000000000923 e126CLINICAL STATEMENTS AND GUIDELINESapproach?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart DiseaseFebruary 2, 2021 Circulation. 2021;143:e72–e227. DOI: 10.1161/CIR.0000000000000923 e126CLINICAL STATEMENTS AND GUIDELINESapproach?. ### Response: Otto et al.


Instruction: What type of patient should be treated in a Comprehensive Valve Center?

Output: asymptomatic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of patient should be treated in a Comprehensive Valve Center?. ### Response: asymptomatic.


Instruction: Patients with severe MR from flail leaflets undergo what type of operation instead of watchful operation?

Output: early operation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with severe MR from flail leaflets undergo what type of operation instead of watchful operation?. ### Response: early operation.


Instruction: Who has a lower risk of developing HF and lower mortality rates?

Output: patients with severe MR from flail leaflets

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who has a lower risk of developing HF and lower mortality rates?. ### Response: patients with severe MR from flail leaflets.


Instruction: What may lead to progressively more severe MR as the initial level of MR causes LV dilation?

Output: MR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may lead to progressively more severe MR as the initial level of MR causes LV dilation?. ### Response: MR.


Instruction: What causes a perpetual cycle of ever-increasing LV volumes and MR?

Output: LV dilation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes a perpetual cycle of ever-increasing LV volumes and MR?. ### Response: LV dilation.


Instruction: Longstanding volume overload leads to irreversible LV dysfunction and a poorer prognosis?

Output: 24,27–29 In excellent hands, patients with severe MR from flail leaflets who undergo early operation as opposed to watchful waiting have a lower risk of developing HF and lower mortality rates.4,13,155. MR may lead to progressively more severe MR as the initial level of MR causes LV dilation, which increases stress on the mitral apparatus, caus-ing further damage to the valve apparatus, more severe MR, and further LV dilation—thus initiating a perpetual cycle of ever-increasing LV volumes and MR. Longstanding volume overload leads to irreversible LV dysfunction and a poorer progno-sis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Longstanding volume overload leads to irreversible LV dysfunction and a poorer prognosis?. ### Response: 24,27–29 In excellent hands, patients with severe MR from flail leaflets who undergo early operation as opposed to watchful waiting have a lower risk of developing HF and lower mortality rates.4,13,155. MR may lead to progressively more severe MR as the initial level of MR causes LV dilation, which increases stress on the mitral apparatus, caus-ing further damage to the valve apparatus, more severe MR, and further LV dilation—thus initiating a perpetual cycle of ever-increasing LV volumes and MR. Longstanding volume overload leads to irreversible LV dysfunction and a poorer progno-sis.


Instruction: Patients with severe MR who develop an LVEF develop what?

Output: LV systolic dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with severe MR who develop an LVEF develop what?. ### Response: LV systolic dysfunction.


Instruction: What is a poorer prognosis?

Output: irreversible LV dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a poorer prognosis?. ### Response: irreversible LV dysfunction.


Instruction: Patients with severe MR who develop an LVEF 60% or LVESD 40 mm have already developed what?

Output: HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with severe MR who develop an LVEF 60% or LVESD 40 mm have already developed what?. ### Response: HF.


Instruction: One study has sug-gested that for LV function and size to return to normal after mitral valve repair, what should be >64%?

Output: LVEF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: One study has sug-gested that for LV function and size to return to normal after mitral valve repair, what should be >64%?. ### Response: LVEF.


Instruction: What should be >64%?

Output: LVEF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be >64%?. ### Response: LVEF.


Instruction: What should LVESD be 37 mm?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should LVESD be 37 mm?. ### Response: <.


Instruction: When does lon-gitudinal follow-up show a progressive decrease of LVEF toward 60%?

Output: it is rea-sonable to consider intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When does lon-gitudinal follow-up show a progressive decrease of LVEF toward 60%?. ### Response: it is rea-sonable to consider intervention.


Instruction: How often is TTE recommended in severe MR?

Output: 3- to 6-month intervals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often is TTE recommended in severe MR?. ### Response: 3- to 6-month intervals.


Instruction: How often are mitral transcatheter edge-to-edge repair (TEER) performed?

Output: ≥1 locations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often are mitral transcatheter edge-to-edge repair (TEER) performed?. ### Response: ≥1 locations.


Instruction: What is TEER?

Output: Mitral transcatheter edge-to-edge repair

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is TEER?. ### Response: Mitral transcatheter edge-to-edge repair.


Instruction: Where are the leaflets clipped together?

Output: ≥1 locations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are the leaflets clipped together?. ### Response: ≥1 locations.


Instruction: MR who are at high or prohibitive surgi-cal risk?

Output: pri-mary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: MR who are at high or prohibitive surgi-cal risk?. ### Response: pri-mary.


Instruction: Studies of TEER with a mitral valve clip have shown improved symptoms and a reduction in MR by how many grades?

Output: 2 to 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Studies of TEER with a mitral valve clip have shown improved symptoms and a reduction in MR by how many grades?. ### Response: 2 to 3.


Instruction: What is less suitable for mitral repair compared with complex degenerative disease?

Output: Rheumatic mitral valve disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is less suitable for mitral repair compared with complex degenerative disease?. ### Response: Rheumatic mitral valve disease.


Instruction: What is limited by thickened mitral valves?

Output: damage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is limited by thickened mitral valves?. ### Response: damage.


Instruction: How long does it take to repair a degenerative disease?

Output: 20 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take to repair a degenerative disease?. ### Response: 20 years.


Instruction: What is the range of freedom from reoperation at 20 years even in experienced hands?

Output: 50% to 60%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the range of freedom from reoperation at 20 years even in experienced hands?. ### Response: 50% to 60%.


Instruction: In a large series from Korea, repair is limited by thickened or calcified leaflets, extensive subval-vular disease with chordal fusion and what else?

Output: shortening

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In a large series from Korea, repair is limited by thickened or calcified leaflets, extensive subval-vular disease with chordal fusion and what else?. ### Response: shortening.


Instruction: How many patients underwent repair for rheumatic dis-ease?

Output: 22%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients underwent repair for rheumatic dis-ease?. ### Response: 22%.


Instruction: What percentage of patients had significant stenosis or regurgitation at 10 years?

Output: One-third

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients had significant stenosis or regurgitation at 10 years?. ### Response: One-third.


Instruction: How should repair be limited to patients with less advanced disease?

Output: rheumatic mitral valve disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How should repair be limited to patients with less advanced disease?. ### Response: rheumatic mitral valve disease.


Instruction: How many patients were ysis of evidence-based indicators in 2014?

Output: 260 000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were ysis of evidence-based indicators in 2014?. ### Response: 260 000.


Instruction: What is the doi: 10.3238/arztebl.2014.0759?

Output: evidence-based indicators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the doi: 10.3238/arztebl.2014.0759?. ### Response: evidence-based indicators.


Instruction: How many states did the Centers for Disease Control and Prevention use a registry to improve?

Output: seven

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many states did the Centers for Disease Control and Prevention use a registry to improve?. ### Response: seven.


Instruction: What is the association of Get With The Guidelines-Stroke program participation and clinical outcomes for Medicare beneficiaries with ischemic stroke?

Output: 30-day mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association of Get With The Guidelines-Stroke program participation and clinical outcomes for Medicare beneficiaries with ischemic stroke?. ### Response: 30-day mortality.


Instruction: Stroke. 2016;47:1294–1302. WHO: Hills NK, Johnston SC. Duration of hospital participation and what?

Output: improved quality of care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Stroke. 2016;47:1294–1302. WHO: Hills NK, Johnston SC. Duration of hospital participation and what?. ### Response: improved quality of care.


Instruction: What is duration of hospital participation in a nation-wide stroke registry associated with?

Output: improved quality of care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is duration of hospital participation in a nation-wide stroke registry associated with?. ### Response: improved quality of care.


Instruction: What is the name of the subgroup analysis of the NINDS t-PA Stroke Trial?

Output: placebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the subgroup analysis of the NINDS t-PA Stroke Trial?. ### Response: placebo.