Instruction: What is angiotensin-converting enzyme inhibitors used for?

Output: drugs and pregnancy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is angiotensin-converting enzyme inhibitors used for?. ### Response: drugs and pregnancy.


Instruction: What is a systematic review of angio-tensine II receptor blockers for treating essential hypertension?

Output: comparativeeffectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a systematic review of angio-tensine II receptor blockers for treating essential hypertension?. ### Response: comparativeeffectiveness.


Instruction: What predicts a slower decrease in long-term renal function?

Output: An acute fall in estimatedglomerular ﬁltration rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What predicts a slower decrease in long-term renal function?. ### Response: An acute fall in estimatedglomerular ﬁltration rate.


Instruction: What is a biomeasure of therapeutic efficacy?

Output: Acute fall in glomerular ﬁltra tion rate with renin-angiotensin systeminhibition

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a biomeasure of therapeutic efficacy?. ### Response: Acute fall in glomerular ﬁltra tion rate with renin-angiotensin systeminhibition.


Instruction: What is the filtra tion rate with renin-angiotensin systeminhibition a biomeasure of?

Output: therapeutic success

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the filtra tion rate with renin-angiotensin systeminhibition a biomeasure of?. ### Response: therapeutic success.


Instruction: What is Bomback AS, Klemmer PJ?

Output: The incidence and implications of aldosteronebreakthrough

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Bomback AS, Klemmer PJ?. ### Response: The incidence and implications of aldosteronebreakthrough.


Instruction: What is the N Engl J Med 2002 347: 1256–1261.91?

Output: Renal dysfunction complicating the treatment of hyperten-sion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the N Engl J Med 2002 347: 1256–1261.91?. ### Response: Renal dysfunction complicating the treatment of hyperten-sion.


Instruction: What is acute renal failure after the use ofangiotensin-converting-enzyme inhibitors?

Output: renalartery stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is acute renal failure after the use ofangiotensin-converting-enzyme inhibitors?. ### Response: renalartery stenosis.


Instruction: What is the name of the hospital-based prospective study of acute renal failure in the elderly?

Output: Nephrol Dial Transplant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the hospital-based prospective study of acute renal failure in the elderly?. ### Response: Nephrol Dial Transplant.


Instruction: What was the title of the study in 2000?

Output: NephrolDial Transplant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the title of the study in 2000?. ### Response: NephrolDial Transplant.


Instruction: How long did it take to follow up an acute renalfailure caused by angiotensin converting enzyme inhibitors?

Output: Long-term

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take to follow up an acute renalfailure caused by angiotensin converting enzyme inhibitors?. ### Response: Long-term.


Instruction: What year did Am JHypertens 11: 1080-1086.94?

Output: 1998

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Am JHypertens 11: 1080-1086.94?. ### Response: 1998.


Instruction: What is the cause of nephrotoxicity in the elderly?

Output: co-prescription of angiotensin converting enzyme inhibitors andnonsteroidal anti-inﬂammatory drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cause of nephrotoxicity in the elderly?. ### Response: co-prescription of angiotensin converting enzyme inhibitors andnonsteroidal anti-inﬂammatory drugs.


Instruction: When did J R Soc Med 2001: 512-514?

Output: 94

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J R Soc Med 2001: 512-514?. ### Response: 94.


Instruction: What is the name of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure?

Output: NMA/PCNA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure?. ### Response: NMA/PCNA.


Instruction: How long did it take to treat severe coarctation of the aorta?

Output: 21-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take to treat severe coarctation of the aorta?. ### Response: 21-year.


Instruction: What is left ventricular outflow obstruction?

Output: subaor -tic stenosis, bicuspid aortic valve, supravalvar aortic stenosis, and coarctation of the aorta

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is left ventricular outflow obstruction?. ### Response: subaor -tic stenosis, bicuspid aortic valve, supravalvar aortic stenosis, and coarctation of the aorta.


Instruction: What is supravalvar aortic stenosis?

Output: obliteration of the descending arch

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is supravalvar aortic stenosis?. ### Response: obliteration of the descending arch.


Instruction: How is the coarctation of the Aorta described?

Output: mean age 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the coarctation of the Aorta described?. ### Response: mean age 3.


Instruction: How many autopsied cases of the adult type, 2 years of age or older were reviewed?

Output: 104

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many autopsied cases of the adult type, 2 years of age or older were reviewed?. ### Response: 104.


Instruction: What year did Am Heart J. 33:146–68?

Output: 1947

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Am Heart J. 33:146–68?. ### Response: 1947.


Instruction: How old were 104 cases of coarctation of the aorta?

Output: 2 years of age or older

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old were 104 cases of coarctation of the aorta?. ### Response: 2 years of age or older.


Instruction: How long after surgical repair is coarctation of the aorta life and health?

Output: 20–44 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after surgical repair is coarctation of the aorta life and health?. ### Response: 20–44 years.


Instruction: What year did Br Heart J. 1993:69:65-70?

Output: 1993

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Br Heart J. 1993:69:65-70?. ### Response: 1993.


Instruction: What are the long term results of surgical repair of aortic coarctation?

Output: 15–30 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the long term results of surgical repair of aortic coarctation?. ### Response: 15–30 years.


Instruction: What is the name of the journal that deals with stenosis and obliteration of the Aorta of the adult type?

Output: Lancet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that deals with stenosis and obliteration of the Aorta of the adult type?. ### Response: Lancet.


Instruction: How many recorded cases with autopsy were of stenosis or obliteration of the descending arch in subjects above the age of 2 years?

Output: 200

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many recorded cases with autopsy were of stenosis or obliteration of the descending arch in subjects above the age of 2 years?. ### Response: 200.


Instruction: What was the age range of subjects above 2 years in 1928?

Output: 3:574–618

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the age range of subjects above 2 years in 1928?. ### Response: 3:574–618.


Instruction: What is the median age of children having operative or endovascular treatment of coarctation of the aorta?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the median age of children having operative or endovascular treatment of coarctation of the aorta?. ### Response: 3.


Instruction: What is the mean age of coarctation of the aorta?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the mean age of coarctation of the aorta?. ### Response: 3.


Instruction: What was the study of exercise response to left ventricular mass and geometry?

Output: Correlation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the study of exercise response to left ventricular mass and geometry?. ### Response: Correlation.


Instruction: How old was the patient at the time of treatment?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old was the patient at the time of treatment?. ### Response: 3.


Instruction: Who was the author of the study?

Output: Krieger

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the author of the study?. ### Response: Krieger.


Instruction: What is the name of the 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults?

Output: Whelton PK, Carey RM, Aronow WS, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults?. ### Response: Whelton PK, Carey RM, Aronow WS, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.


Instruction: What year did the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines publish a report?

Output: 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines publish a report?. ### Response: 2018.


Instruction: What are the Clinical Practice Guidelines?

Output: AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Clinical Practice Guidelines?. ### Response: AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults.


Instruction: What are Right-Sided Lesions4.3.1.

Output: Valvular Pulmonary Stenosis S4.3.1-1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are Right-Sided Lesions4.3.1.. ### Response: Valvular Pulmonary Stenosis S4.3.1-1.


Instruction: What is the long-term outcome after treatment of isolated pulmonary valve stenosis?

Output: S4.3.1-2. Kaul UA, Singh B, Tyagi S, et al. Long-term results after balloon pulmonary valvuloplasty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the long-term outcome after treatment of isolated pulmonary valve stenosis?. ### Response: S4.3.1-2. Kaul UA, Singh B, Tyagi S, et al. Long-term results after balloon pulmonary valvuloplasty.


Instruction: What type of balloon pulmonary valvuloplasty has long-term results in adults?

Output: Percutaneous inter -ventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of balloon pulmonary valvuloplasty has long-term results in adults?. ### Response: Percutaneous inter -ventions.


Instruction: What is the name of the procedure performed in 1993?

Output: balloon pulmonary valvuloplasty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the procedure performed in 1993?. ### Response: balloon pulmonary valvuloplasty.


Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al.


Instruction: What is the PMBC formed by?

Output: advancing one or more balloon cath-eters across the mitral valve and inflating them

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the PMBC formed by?. ### Response: advancing one or more balloon cath-eters across the mitral valve and inflating them.


Instruction: How many balloon cath-eters are per-formed?

Output: one or more

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many balloon cath-eters are per-formed?. ### Response: one or more.


Instruction: What is formed by advancing one or more balloon cath-eters across the mitral valve and inflating them?

Output: PMBC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is formed by advancing one or more balloon cath-eters across the mitral valve and inflating them?. ### Response: PMBC.


Instruction: Favorable valve morphology consists of mobile and relatively thin valve leaflets, which are free of what?

Output: calcium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Favorable valve morphology consists of mobile and relatively thin valve leaflets, which are free of what?. ### Response: calcium.


Instruction: What can an anatomic mitral morphology score determine?

Output: suitability for PMBC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can an anatomic mitral morphology score determine?. ### Response: suitability for PMBC.


Instruction: What can be used to determine suitability for PMBC and evaluate the appearance of the commissures and degree of calcification?

Output: An anatomic mitral morphology score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be used to determine suitability for PMBC and evaluate the appearance of the commissures and degree of calcification?. ### Response: An anatomic mitral morphology score.


Instruction: Age, NYHA class, and presence or absence of AF are also predictive of what?

Output: outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Age, NYHA class, and presence or absence of AF are also predictive of what?. ### Response: outcome.


Instruction: What are also predictive of outcome?

Output: Clinical factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are also predictive of outcome?. ### Response: Clinical factors.


Instruction: Older patients with lower gradients (10 mm Hg) will not have as good an outcome as patients with higher gradients?

Output: higher gra-dients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Older patients with lower gradients (10 mm Hg) will not have as good an outcome as patients with higher gradients?. ### Response: higher gra-dients.


Instruction: What are concomitant problems that cause symptoms?

Output: LV dia-stolic dysfunction and LA noncompliance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are concomitant problems that cause symptoms?. ### Response: LV dia-stolic dysfunction and LA noncompliance.


Instruction: PMBC should be what?

Output: performed only by experienced operators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: PMBC should be what?. ### Response: performed only by experienced operators.


Instruction: What is LA noncompliance measured by?

Output: net atrial–ventricular compliance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is LA noncompliance measured by?. ### Response: net atrial–ventricular compliance.


Instruction: PMBC should only be performed by experienced operators with what kind of backup?

Output: surgical

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: PMBC should only be performed by experienced operators with what kind of backup?. ### Response: surgical.


Instruction: What percentage of patients with an initial good result after PMBC are free of recurrent symptoms at 10 years?

Output: 70% to 80%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients with an initial good result after PMBC are free of recurrent symptoms at 10 years?. ### Response: 70% to 80%.


Instruction: What is an established therapy for rheumatic MS?

Output: Mitral valve surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an established therapy for rheumatic MS?. ### Response: Mitral valve surgery.


Instruction: What is the preferred approach for mitral valve surgery?

Output: commissurotomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the preferred approach for mitral valve surgery?. ### Response: commissurotomy.


Instruction: When is the valve opened blindly through the LA or LV?

Output: issurotomy (either closed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is the valve opened blindly through the LA or LV?. ### Response: issurotomy (either closed.


Instruction: What allows more extensive surgery under direct visual-ization?

Output: issurotomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What allows more extensive surgery under direct visual-ization?. ### Response: issurotomy.


Instruction: In the presence of severe valvular thickening, what may be the best option?

Output: mitral valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the presence of severe valvular thickening, what may be the best option?. ### Response: mitral valve replacement.


Instruction: What may be the best option for patients with suboptimal valve anatomy?

Output: mitral valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be the best option for patients with suboptimal valve anatomy?. ### Response: mitral valve replacement.


Instruction: Patients with moderate or severe TR may have a better outcome with what approach?

Output: surgi-cal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with moderate or severe TR may have a better outcome with what approach?. ### Response: surgi-cal.


Instruction: What may include tricuspid valve repair?

Output: surgi-cal approach

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may include tricuspid valve repair?. ### Response: surgi-cal approach.


Instruction: What type of commissurotomy may have better long-term outcomes than PMBC?

Output: surgical

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of commissurotomy may have better long-term outcomes than PMBC?. ### Response: surgical.


Instruction: What is the natural history of rheumatic MS?

Output: slow progression over decades

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the natural history of rheumatic MS?. ### Response: slow progression over decades.


Instruction: Surgery should be delayed until the patient has what?

Output: severe limiting symptoms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Surgery should be delayed until the patient has what?. ### Response: severe limiting symptoms.


Instruction: What is a class III or IV of NYHA?

Output: severe limiting symptoms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a class III or IV of NYHA?. ### Response: severe limiting symptoms.


Instruction: What is an indication that there is progressive elevation of pulmonary artery pressure?

Output: an elevation of pulmonary artery pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an indication that there is progressive elevation of pulmonary artery pressure?. ### Response: an elevation of pulmonary artery pressure.


Instruction: What is an indication that there is progressive elevation of LA pressure affecting the pulmonary circulation?

Output: an elevation of pulmonary artery pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an indication that there is progressive elevation of LA pressure affecting the pulmonary circulation?. ### Response: an elevation of pulmonary artery pressure.


Instruction: What can be assessed by Doppler echocardiography?

Output: An elevated pulmonary pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be assessed by Doppler echocardiography?. ### Response: An elevated pulmonary pressure.


Instruction: What percentage of the cohort had prediabetes?

Output: 42%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the cohort had prediabetes?. ### Response: 42%.


Instruction: What was the baseline fastingserum glucose >100 mg/dl?

Output: 5.6 mmol/l].

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the baseline fastingserum glucose >100 mg/dl?. ### Response: 5.6 mmol/l]..


Instruction: How many participants were included with CKD?

Output: 4983

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many participants were included with CKD?. ### Response: 4983.


Instruction: What did post hoc analysis of SPRINT compare participants with and without prediabetes find?

Output: the CV and survival bene ﬁts of intensive SBPreduction ( <120 mm Hg) were similar in the 2 subgroups

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did post hoc analysis of SPRINT compare participants with and without prediabetes find?. ### Response: the CV and survival bene ﬁts of intensive SBPreduction ( <120 mm Hg) were similar in the 2 subgroups.


Instruction: What was the CV and survival bene fits of intensive SBPreduction similar in the 2 subgroups?

Output: <120 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the CV and survival bene fits of intensive SBPreduction similar in the 2 subgroups?. ### Response: <120 mm Hg.


Instruction: Other secondary analyses of what data suggest that intensive SBP lowering is beneficial?

Output: ACCORD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Other secondary analyses of what data suggest that intensive SBP lowering is beneficial?. ### Response: ACCORD.


Instruction: What did a combined post hocanalysis of SPRINT and ACCORD suggest?

Output: similar CVbeneﬁts of intensive BP-lowering therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a combined post hocanalysis of SPRINT and ACCORD suggest?. ### Response: similar CVbeneﬁts of intensive BP-lowering therapy.


Instruction: What was a BP trial but also employed a rather complex study design?

Output: ACCORD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a BP trial but also employed a rather complex study design?. ### Response: ACCORD.


Instruction: How was the trial of glycemiccontrol terminated early?

Output: because of higher all-causemortality with intensive glycemic control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the trial of glycemiccontrol terminated early?. ### Response: because of higher all-causemortality with intensive glycemic control.


Instruction: What was the effect of intensive versus less-intensive BP control?

Output: increased CV death, HF, and MI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the effect of intensive versus less-intensive BP control?. ### Response: increased CV death, HF, and MI.


Instruction: What was higher all-causemortality with intensive glycemic control?

Output: 92

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was higher all-causemortality with intensive glycemic control?. ### Response: 92.


Instruction: What was also demonstrated in the CKD subgroup of ACCORD?

Output: adverse ef-fect of intensive glycemic control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was also demonstrated in the CKD subgroup of ACCORD?. ### Response: adverse ef-fect of intensive glycemic control.


Instruction: What did the combined analysis of ACCORD and SPRINT show?

Output: similar CVbeneﬁts of intensive BP-lowering therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the combined analysis of ACCORD and SPRINT show?. ### Response: similar CVbeneﬁts of intensive BP-lowering therapy.


Instruction: What did intensive SBPcontrol increase?

Output: CV death, HF, and MI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did intensive SBPcontrol increase?. ### Response: CV death, HF, and MI.


Instruction: How was the combined CV endpoints and onall-cause mortality similar?

Output: similar in the standard glycemia armof ACCORD and in SPRINT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the combined CV endpoints and onall-cause mortality similar?. ### Response: similar in the standard glycemia armof ACCORD and in SPRINT.


Instruction: What increased CV death, HF, and MI in the intensiveglycemia arm?

Output: intensive SBPcontrol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What increased CV death, HF, and MI in the intensiveglycemia arm?. ### Response: intensive SBPcontrol.


Instruction: After discontinua-tion of the glycemic intervention, what did these interactions lessen?

Output: increased CV death, HF, and MI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: After discontinua-tion of the glycemic intervention, what did these interactions lessen?. ### Response: increased CV death, HF, and MI.


Instruction: What did intensive BPcontrol increase in the ACCORD group?

Output: CV death, HF, and MI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did intensive BPcontrol increase in the ACCORD group?. ### Response: CV death, HF, and MI.


Instruction: What did intensive BP control provide similar to those seen in SPRINT?

Output: CV bene ﬁts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did intensive BP control provide similar to those seen in SPRINT?. ### Response: CV bene ﬁts.


Instruction: What did a pooled analysis of individual patient data from4983 patients with CKD from AASK, MDRD, ACCORD andSPRINT find?

Output: a non-signi ﬁcant trend to decreased mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a pooled analysis of individual patient data from4983 patients with CKD from AASK, MDRD, ACCORD andSPRINT find?. ### Response: a non-signi ﬁcant trend to decreased mortality.


Instruction: What is the trend to decreased mortality with intensive BP-lowering therapy?

Output: non-signi ﬁcant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the trend to decreased mortality with intensive BP-lowering therapy?. ### Response: non-signi ﬁcant.


Instruction: What is a statistical signifi-cant reduction in mortality in a subgroup with eGFR 60ml/min per 1.73 m2who were not assigned to intensive gly-cemic control?

Output: 125

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a statistical signifi-cant reduction in mortality in a subgroup with eGFR 60ml/min per 1.73 m2who were not assigned to intensive gly-cemic control?. ### Response: 125.


Instruction: What does glycemic control modulate the effects of intensiveBP control on?

Output: CV outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does glycemic control modulate the effects of intensiveBP control on?. ### Response: CV outcomes.


Instruction: What does indirect evidence reduce the certainty of?

Output: bene ﬁts and strength ofrecommendation of targeting SBP <120 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does indirect evidence reduce the certainty of?. ### Response: bene ﬁts and strength ofrecommendation of targeting SBP <120 mm Hg.


Instruction: Do obese VTE patients need a DOAC or an alternative anticoagulant fortreatment of VTE?

Output: For patients requiring administration of inhibitors orinducers of P-gp or strong inhibitors or inducers of CYP enzymes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Do obese VTE patients need a DOAC or an alternative anticoagulant fortreatment of VTE?. ### Response: For patients requiring administration of inhibitors orinducers of P-gp or strong inhibitors or inducers of CYP enzymes.


Instruction: What type of evidence is available for different LMWH initiation dosing strate-gies?

Output: comparative

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of evidence is available for different LMWH initiation dosing strate-gies?. ### Response: comparative.


Instruction: Do patients require administration of inhibitors or inducers of CYP enzymes or strong inhibitors of P-gp?

Output: P-gp inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Do patients require administration of inhibitors or inducers of CYP enzymes or strong inhibitors of P-gp?. ### Response: P-gp inhibitors.


Instruction: What does the ASHguideline panel suggest instead of a DOAC for the treatment of VTE?

Output: an alternative anticoagulant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the ASHguideline panel suggest instead of a DOAC for the treatment of VTE?. ### Response: an alternative anticoagulant.


Instruction: What is the conditional recommendation based on?

Output: very low cer-tainty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the conditional recommendation based on?. ### Response: very low cer-tainty.


Instruction: What is mediated by P-gp proteins?

Output: DOAC absorption

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is mediated by P-gp proteins?. ### Response: DOAC absorption.


Instruction: What can increase or decrease DOAC absorption and effect?

Output: P-gp inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can increase or decrease DOAC absorption and effect?. ### Response: P-gp inhibitors.


Instruction: What are the implications for Strong recommendation Conditional recommendationPatients Most individuals in this situation would want the recommended course of action, but only a small proportion would not?

Output: further research may provideimportant information that alters the recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the implications for Strong recommendation Conditional recommendationPatients Most individuals in this situation would want the recommended course of action, but only a small proportion would not?. ### Response: further research may provideimportant information that alters the recommendations.


Instruction: Decision aids may be useful in what situation?

Output: helping patients to make decisions consistentwith their individual risks, values, and preferences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Decision aids may be useful in what situation?. ### Response: helping patients to make decisions consistentwith their individual risks, values, and preferences.


Instruction: What type of decision aids are not likely to be needed to help individualpatients make decisions consistent with their values and preferences?

Output: Formal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of decision aids are not likely to be needed to help individualpatients make decisions consistent with their values and preferences?. ### Response: Formal.


Instruction: What can help individuals make decisions consistent with their values and preferences?

Output: Decision aids

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can help individuals make decisions consistent with their values and preferences?. ### Response: Decision aids.


Instruction: What must each patient arrive at a managementdecision consistent with?

Output: their individual risks, values, andpreferences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must each patient arrive at a managementdecision consistent with?. ### Response: their individual risks, values, andpreferences.


Instruction: How can policy makers adopt the recommendation?

Output: as policy in most situations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can policy makers adopt the recommendation?. ### Response: as policy in most situations.


Instruction: What can be used as a quality criterion or performance indicator?

Output: Adherence to this recommendation according to the guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be used as a quality criterion or performance indicator?. ### Response: Adherence to this recommendation according to the guideline.


Instruction: What should assess whether decision-making is appropriate?

Output: Performance measures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should assess whether decision-making is appropriate?. ### Response: Performance measures.


Instruction: What is supported by credible research or other convincing judgments that make additional research unlikely to alter the recommendation?

Output: Researchers The recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is supported by credible research or other convincing judgments that make additional research unlikely to alter the recommendation?. ### Response: Researchers The recommendation.


Instruction: What may provide important information that alters the recommendations?

Output: further research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may provide important information that alters the recommendations?. ### Response: further research.


Instruction: What is likely to be strengthened (for futureupdates or adaptations) by?

Output: The recommendation is likely to be strengthened (for futureupdates or adaptation) by additional research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is likely to be strengthened (for futureupdates or adaptations) by?. ### Response: The recommendation is likely to be strengthened (for futureupdates or adaptation) by additional research.


Instruction: What type of heart failure referral and approach to care is NICE 2018?

Output: Chronic Heart  Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of heart failure referral and approach to care is NICE 2018?. ### Response: Chronic Heart  Failure.


Instruction: Who considered the MDT to be cost saving and provide a benefit?

Output: the committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who considered the MDT to be cost saving and provide a benefit?. ### Response: the committee.


Instruction: What did the committee agree that the economic evidence did not support?

Output: cardiologist stand -alone clinic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee agree that the economic evidence did not support?. ### Response: cardiologist stand -alone clinic.


Instruction: What was the cost effectiveness of short term MDT intervention?

Output: No studies were identified that assessed the cost effectiveness of short term MDT intervention in  high risk heart failure patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the cost effectiveness of short term MDT intervention?. ### Response: No studies were identified that assessed the cost effectiveness of short term MDT intervention in  high risk heart failure patients.


Instruction: What did the committee agree that an MDT reduce costs overall compared to usual care due to reduced hospitalisations?

Output: economic evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee agree that an MDT reduce costs overall compared to usual care due to reduced hospitalisations?. ### Response: economic evidence.


Instruction: The committee noted that a cardiologist and specialist nurse were what?

Output: included in all of the economic studies reviewed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committee noted that a cardiologist and specialist nurse were what?. ### Response: included in all of the economic studies reviewed.


Instruction: What was included in all of the economic studies reviewed?

Output: a cardiologist and specialist nurse

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was included in all of the economic studies reviewed?. ### Response: a cardiologist and specialist nurse.


Instruction: What should be included in the core MDT?

Output: a physician with a  subspecialty inter est in heart failure, and a specialist heart failure nurse

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be included in the core MDT?. ### Response: a physician with a  subspecialty inter est in heart failure, and a specialist heart failure nurse.


Instruction: What is the current composition of MDTs in clinical practice?

Output: varies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the current composition of MDTs in clinical practice?. ### Response: varies.


Instruction: The core professionals in most teams currently consist of a cardiologi st and what other professional?

Output: specialist nurse

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The core professionals in most teams currently consist of a cardiologi st and what other professional?. ### Response: specialist nurse.


Instruction: What could include many other professionals from other specialties?

Output: core professionals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could include many other professionals from other specialties?. ### Response: core professionals.


Instruction: What did the committee consider the recommendation to have?

Output: cost saving and provide a clinical benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee consider the recommendation to have?. ### Response: cost saving and provide a clinical benefit.


Instruction: What would not have an overall cost impact?

Output: recommendation to have an MDT with a core team consisting of a physician with subspecialty int erest in heart failure, a specialist heart failure nurse, competencies to manage prescribing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would not have an overall cost impact?. ### Response: recommendation to have an MDT with a core team consisting of a physician with subspecialty int erest in heart failure, a specialist heart failure nurse, competencies to manage prescribing.


Instruction: Current NHS practise in this area is what?

Output: variable

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Current NHS practise in this area is what?. ### Response: variable.


Instruction: What did the committee know about the BHF Heart Failure Audit?

Output: this was carried out in a large proportion of NHS hospitals in England a nd Wales, and shows that following a decompensation 70% of patients receive an appointment for a cardiologist, and 60% of patients have a referral to a specialist cardiac nurse

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee know about the BHF Heart Failure Audit?. ### Response: this was carried out in a large proportion of NHS hospitals in England a nd Wales, and shows that following a decompensation 70% of patients receive an appointment for a cardiologist, and 60% of patients have a referral to a specialist cardiac nurse.


Instruction: What percentage of hospitals in England and Wales had a decompensation audit?

Output: 70%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of hospitals in England and Wales had a decompensation audit?. ### Response: 70%.


Instruction: What percentage of patients receive an appointment for a cardiologist after a decompensation?

Output: 70%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients receive an appointment for a cardiologist after a decompensation?. ### Response: 70%.


Instruction: How many patients have a referral to a specialist cardiac nurse?

Output: 60%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients have a referral to a specialist cardiac nurse?. ### Response: 60%.


Instruction: What did the cardiologists consider the HF nurses to be?

Output: invaluable

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the cardiologists consider the HF nurses to be?. ### Response: invaluable.


Instruction: Who considered the HF nurses invaluable in managing their caseloads and clinics?

Output: cardiologists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who considered the HF nurses invaluable in managing their caseloads and clinics?. ### Response: cardiologists.


Instruction: Who could often take on the management of the heart failure patients who were in need of more comprehensive support?

Output: The specialist nurses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who could often take on the management of the heart failure patients who were in need of more comprehensive support?. ### Response: The specialist nurses.


Instruction: What kind of support and care could not be replicated by a cardiologist stand-alone clinic?

Output: psychological

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What kind of support and care could not be replicated by a cardiologist stand-alone clinic?. ### Response: psychological.


Instruction: What has been the practice in the UK in many areas for specialist nurses or prescribers to optimise evidence based medication?

Output: ACE -inhibitors and beta -blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been the practice in the UK in many areas for specialist nurses or prescribers to optimise evidence based medication?. ### Response: ACE -inhibitors and beta -blockers.


Instruction: What are ACE -inhibitors and beta -blockers?

Output: evidence -based medication

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are ACE -inhibitors and beta -blockers?. ### Response: evidence -based medication.


Instruction: Where is evidence -based medication determined?

Output: locally

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is evidence -based medication determined?. ### Response: locally.


Instruction: What did the committee hear patients valued?

Output: someone to speak to about their illness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee hear patients valued?. ### Response: someone to speak to about their illness.


Instruction: What type of CKD has been confirmed in patients with or without diabetes?

Output: albuminuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of CKD has been confirmed in patients with or without diabetes?. ### Response: albuminuria.


Instruction: What group believes patients and providers would want to avoid hyperkalemia and AKI?

Output: The Work Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What group believes patients and providers would want to avoid hyperkalemia and AKI?. ### Response: The Work Group.


Instruction: What does dual RASi therapy decrease proteinuria?

Output: very high levels of albuminuri

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does dual RASi therapy decrease proteinuria?. ### Response: very high levels of albuminuri.


Instruction: What is a consideration for implementation?

Output: Resource use and costs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a consideration for implementation?. ### Response: Resource use and costs.


Instruction: What type of therapy is used to treat very high levels of albuminuriain selected patients?

Output: dual therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is used to treat very high levels of albuminuriain selected patients?. ### Response: dual therapy.


Instruction: There is no RCT data on what?

Output: safety orkidney

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is no RCT data on what?. ### Response: safety orkidney.


Instruction: What are dedicated clinics superior to?

Output: historical controls

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are dedicated clinics superior to?. ### Response: historical controls.


Instruction: What is insuf ficient todifferentiate between men and women for this recommenda-tion?

Output: 294There is insuf ﬁcient information

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is insuf ficient todifferentiate between men and women for this recommenda-tion?. ### Response: 294There is insuf ﬁcient information.


Instruction: What should be discouraged for patients with CKD?

Output: dual therapys

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be discouraged for patients with CKD?. ### Response: dual therapys.


Instruction: What is the belief that dual therapies of RASi are beneficial compared to monotherapies stemmed only from?

Output: theimprovement in albuminuria with dual therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the belief that dual therapies of RASi are beneficial compared to monotherapies stemmed only from?. ### Response: theimprovement in albuminuria with dual therapy.


Instruction: What did the addition of an MRA to an ACEi or ARB for renoprotection inpatients with diabetes and kidney disease result in?

Output: a reduc-tion of albuminuria but a higher risk of hyperkalemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the addition of an MRA to an ACEi or ARB for renoprotection inpatients with diabetes and kidney disease result in?. ### Response: a reduc-tion of albuminuria but a higher risk of hyperkalemia.


Instruction: What was reduced by adding spironolactone, epler-enone, or finerenone?

Output: albuminuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was reduced by adding spironolactone, epler-enone, or finerenone?. ### Response: albuminuria.


Instruction: No adequately powered study has been completed with spi-ronolactone or eplerenone?

Output: Beyondalbuminuria, no adequately powered study examining GFRand kidney failure outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No adequately powered study has been completed with spi-ronolactone or eplerenone?. ### Response: Beyondalbuminuria, no adequately powered study examining GFRand kidney failure outcomes.


Instruction: The FIDELIOtrial showed kidney and cardiovascular protection by finer-enone despite its modest effect on what?

Output: SBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The FIDELIOtrial showed kidney and cardiovascular protection by finer-enone despite its modest effect on what?. ### Response: SBP.


Instruction: What is the FIGARO trial testing on the background of an ACEi or ARB in patients with diabetes and kidney disease?

Output: erenone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the FIGARO trial testing on the background of an ACEi or ARB in patients with diabetes and kidney disease?. ### Response: erenone.


Instruction: What are the benefits of dual versus monotherapy in people with CKD without diabetes?

Output: major kidneyoutcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the benefits of dual versus monotherapy in people with CKD without diabetes?. ### Response: major kidneyoutcomes.


Instruction: What has not been wellstudied in people with CKD without diabetes and proteinuria?

Output: The bene ﬁts of dual versus monotherapy on major kidneyoutcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has not been wellstudied in people with CKD without diabetes and proteinuria?. ### Response: The bene ﬁts of dual versus monotherapy on major kidneyoutcomes.


Instruction: What should be curtailing the risks of hyperkalemia and AKI?

Output: Future trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be curtailing the risks of hyperkalemia and AKI?. ### Response: Future trials.


Instruction: What should be directed to identify individuals who will bene fit or experience the benefits of personalized medicine?

Output: research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be directed to identify individuals who will bene fit or experience the benefits of personalized medicine?. ### Response: research.


Instruction: What is the title of the study by Yancy et al. September 27, 2016 Circulation. 2016;134:e282-e293. DOI: 10.1161/CIR.0000000000000435 e290

Output: Novartis† None None

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of the study by Yancy et al. September 27, 2016 Circulation. 2016;134:e282-e293. DOI: 10.1161/CIR.0000000000000435 e290. ### Response: Novartis† None None.


Instruction: What is the name of Amgen?

Output: AstraZeneca

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of Amgen?. ### Response: AstraZeneca.


Instruction: What college is Donald E. Casey, Jr adjunct faculty in?

Output: Thomas Jefferson College of Population Health

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What college is Donald E. Casey, Jr adjunct faculty in?. ### Response: Thomas Jefferson College of Population Health.


Instruction: Who is the Founder of IPO4Health?

Output: Alvarez & Marsal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Founder of IPO4Health?. ### Response: Alvarez & Marsal.


Instruction: Who is the professor of Internal Medicine at the University of Texas Southwestern Medical Center?

Output: Mark H. Drazner

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the professor of Internal Medicine at the University of Texas Southwestern Medical Center?. ### Response: Mark H. Drazner.


Instruction: What is the name of the department of cardiology at the Attikon University Hospital?

Output: Heart Failure Unit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the department of cardiology at the Attikon University Hospital?. ### Response: Heart Failure Unit.


Instruction: Who is the Professor of Cardiology at UCLA?

Output: Gregg C. Fonarow

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Professor of Cardiology at UCLA?. ### Response: Gregg C. Fonarow.


Instruction: What is the name of the UCLA division of cardiology?

Output: Gregg C. FonarowAhmanson-UCLA Cardiomyopathy Center

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the UCLA division of cardiology?. ### Response: Gregg C. FonarowAhmanson-UCLA Cardiomyopathy Center.


Instruction: Where is Gregg C. Fonarow from?

Output: UCLA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Gregg C. Fonarow from?. ### Response: UCLA.


Instruction: What is the name of the professor of medicine at Brigham and Women’s Hospital?

Output: Michael M. Givertz

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor of medicine at Brigham and Women’s Hospital?. ### Response: Michael M. Givertz.


Instruction: Who is the director of the Coronary Care Unit at Cooper University Hospital, Professor of Medicine?

Output: Steven M. Hollenberg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the director of the Coronary Care Unit at Cooper University Hospital, Professor of Medicine?. ### Response: Steven M. Hollenberg.


Instruction: Where is JoAnn Lindenfeld from?

Output: Vanderbilt Heart and Vascular Institute

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is JoAnn Lindenfeld from?. ### Response: Vanderbilt Heart and Vascular Institute.


Instruction: Who is the Director of the Advanced Heart Failure and Transplant Section at Vanderbilt Heart and Vascular Institute?

Output: JoAnn Lindenfeld

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Director of the Advanced Heart Failure and Transplant Section at Vanderbilt Heart and Vascular Institute?. ### Response: JoAnn Lindenfeld.


Instruction: What is the name of the division of cardiology at the University of Colorado, Denver?

Output: Associate Professor of Medicine, Division of CardiologyNone None None None None None NonePatrick E. McBrideUniversity of Wisconsin School of Medicine and Public Health—Professor of Medicine and Family Medicine; Associate Director, Preventive CardiologyNone None None None None None NonePamela N. PetersonUniversity of Colorado, Denver Health Medical Center

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the division of cardiology at the University of Colorado, Denver?. ### Response: Associate Professor of Medicine, Division of CardiologyNone None None None None None NonePatrick E. McBrideUniversity of Wisconsin School of Medicine and Public Health—Professor of Medicine and Family Medicine; Associate Director, Preventive CardiologyNone None None None None None NonePamela N. PetersonUniversity of Colorado, Denver Health Medical Center.


Instruction: Which university is Frederic A. Masoudi affiliated with?

Output: University of Colorado, Denver

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which university is Frederic A. Masoudi affiliated with?. ### Response: University of Colorado, Denver.


Instruction: What is the name of the Associate Professor of Medicine at the University of Colorado, Denver Health Medical Center?

Output: Frederick A. Masoudi

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Associate Professor of Medicine at the University of Colorado, Denver Health Medical Center?. ### Response: Frederick A. Masoudi.


Instruction: Who is the Associate Director of Preventive Cardiology?

Output: Patrick E. McBride

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Associate Director of Preventive Cardiology?. ### Response: Patrick E. McBride.


Instruction: Who is the Director of the Cardiomyopathy and Heart Failure Program at Brigham and Women’s Hospital?

Output: Lynne W. Stevenson

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Director of the Cardiomyopathy and Heart Failure Program at Brigham and Women’s Hospital?. ### Response: Lynne W. Stevenson.


Instruction: What is the name of the Novartis-PARENT trial?

Output: PI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Novartis-PARENT trial?. ### Response: PI.


Instruction: Which company is the Co-PI of NHLBI?

Output: Novartis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which company is the Co-PI of NHLBI?. ### Response: Novartis.


Instruction: What is the name of the committee member who continues to be employed?

Output: ConsultantSpeakers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the committee member who continues to be employed?. ### Response: ConsultantSpeakers.


Instruction: Where can ahajournals.org be accessed by on May 3, 2023?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can ahajournals.org be accessed by on May 3, 2023?. ### Response: http://.


Instruction: What is an example of a committee member employment?

Output: ConsultantSpeakers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a committee member employment?. ### Response: ConsultantSpeakers.


Instruction: What are the normal plasma levels of cardiactroponin I measured by?

Output: high-sensitivity cardiac troponin I accessprototype assay

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the normal plasma levels of cardiactroponin I measured by?. ### Response: high-sensitivity cardiac troponin I accessprototype assay.


Instruction: What is the impact on the diagnosis of myocardial ische-mia?

Output: Normal plasma levels of cardiactroponin I measured by the high-sensitivity cardiac troponin I accessprototype assay

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact on the diagnosis of myocardial ische-mia?. ### Response: Normal plasma levels of cardiactroponin I measured by the high-sensitivity cardiac troponin I accessprototype assay.


Instruction: When was the J Am Coll Cardiol 54:1165–72.205?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol 54:1165–72.205?. ### Response: 2009.


Instruction: What is Hausenloy DJ's profession?

Output: Yellon DM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Hausenloy DJ's profession?. ### Response: Yellon DM.


Instruction: What is the N EnglJ Med. 2007:357:1121–35.206?

Output: Myocardial reperfusion injury

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the N EnglJ Med. 2007:357:1121–35.206?. ### Response: Myocardial reperfusion injury.


Instruction: What year did Ann Thorac Surg. 2008:85:1261–70?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Ann Thorac Surg. 2008:85:1261–70?. ### Response: 2008.


Instruction: Who published the 2011 ACCF/AHA CABG Guideline e705?

Output: Hillis et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2011 ACCF/AHA CABG Guideline e705?. ### Response: Hillis et al.


Instruction: When was the CABG guideline downloaded from http://ahajournals.org?

Output: April 26, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the CABG guideline downloaded from http://ahajournals.org?. ### Response: April 26, 2023.


Instruction: What should you offer at every ant enatal appointment?

Output: fetal hear t auscultation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should you offer at every ant enatal appointment?. ### Response: fetal hear t auscultation.


Instruction: Do you carry out ultrasound assessment of the fetus at diagnosis and, if normal, r epeat e very 2 to 4 weeks?

Output: Carry out ultrasound assessment of the fetus at diagnosis and, if normal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Do you carry out ultrasound assessment of the fetus at diagnosis and, if normal, r epeat e very 2 to 4 weeks?. ### Response: Carry out ultrasound assessment of the fetus at diagnosis and, if normal.


Instruction: If you are clinically indicat ed, do you do a CT G only?

Output: Carry out a CT G only if clinically indicat ed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: If you are clinically indicat ed, do you do a CT G only?. ### Response: Carry out a CT G only if clinically indicat ed.


Instruction: What is the name of the section for advice on fetal monitoring?

Output: 1.6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the section for advice on fetal monitoring?. ### Response: 1.6.


Instruction: What should be done at every ant enatal appointment?

Output: Offer fetal hear t auscultation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be done at every ant enatal appointment?. ### Response: Offer fetal hear t auscultation.


Instruction: How long should ultrasound assessment of the fetus be carried out?

Output: 2 to 4 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long should ultrasound assessment of the fetus be carried out?. ### Response: 2 to 4 weeks.


Instruction: If hyper tension persists, how long does ultrasound assessment last?

Output: 2 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: If hyper tension persists, how long does ultrasound assessment last?. ### Response: 2 weeks.


Instruction: What if hyper tension persists for 2 weeks?

Output: Fetal assessment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What if hyper tension persists for 2 weeks?. ### Response: Fetal assessment.


Instruction: What should be done at diagnosis and only if clinically indicat ed?

Output: Carry out a CT G

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be done at diagnosis and only if clinically indicat ed?. ### Response: Carry out a CT G.


Instruction: What is BP?

Output: blood pr essur e

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is BP?. ### Response: blood pr essur e.


Instruction: What is CT G?

Output: car diotocograph y

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CT G?. ### Response: car diotocograph y.


Instruction: PlGF stands for placental gr owth factor?

Output: PlGF , placental gr owth factor. 1.4.4 Offer placental gr owth factor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: PlGF stands for placental gr owth factor?. ### Response: PlGF , placental gr owth factor. 1.4.4 Offer placental gr owth factor.


Instruction: What is a placental g owth factor?

Output: PlGF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a placental g owth factor?. ### Response: PlGF.


Instruction: How long does it take to rule out pr e-eclampsia?

Output: 20  weeks and 36 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take to rule out pr e-eclampsia?. ### Response: 20  weeks and 36 weeks.


Instruction: How many weeks and 6 da ys of pr egnancy?

Output: 36

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many weeks and 6 da ys of pr egnancy?. ### Response: 36.


Instruction: What does NICE diagnostics guidance on PlGF-based t esting help diagnose?

Output: suspect ed pr eterm pr e-eclampsia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does NICE diagnostics guidance on PlGF-based t esting help diagnose?. ### Response: suspect ed pr eterm pr e-eclampsia.


Instruction: When was NICE's guidance amended?

Output: 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was NICE's guidance amended?. ### Response: 2023.


Instruction: What does labetalol do to treat gestational h yper tension?

Output: Consider labetalol t o

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does labetalol do to treat gestational h yper tension?. ### Response: Consider labetalol t o.


Instruction: What is nifedipine not suitable for women in which it is not suitable?

Output: labetalol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is nifedipine not suitable for women in which it is not suitable?. ### Response: labetalol.


Instruction: Where should t he choice be based on?

Output: side-eff ect profiles, risk (including f etal eff ects) and t he w oman's pr eferences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where should t he choice be based on?. ### Response: side-eff ect profiles, risk (including f etal eff ects) and t he w oman's pr eferences.


Instruction: What does not off er bed r est in hospital as a tr eatment f or gestational hyper tension?

Output: 1.4.6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not off er bed r est in hospital as a tr eatment f or gestational hyper tension?. ### Response: 1.4.6.


Instruction: What is t he w oman's pr eferences?

Output: BP , blood pr essur e; CT G, car diotocograph y; PlGF , placental gr owth factor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is t he w oman's pr eferences?. ### Response: BP , blood pr essur e; CT G, car diotocograph y; PlGF , placental gr owth factor.


Instruction: What is hyper tension in pregnancy?

Output: severe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hyper tension in pregnancy?. ### Response: severe.


Instruction: What is NICE 2023?

Output: Hyper tension in pr egnancy: diagnosis and management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE 2023?. ### Response: Hyper tension in pr egnancy: diagnosis and management.


Instruction: What date was the last updat ed?

Output: 17 April 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What date was the last updat ed?. ### Response: 17 April 2023.


Instruction: How many pages of 59 were on this page?

Output: 16

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many pages of 59 were on this page?. ### Response: 16.


Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020 Page 3 of 127 Table of Contents

Output: I. Introduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020 Page 3 of 127 Table of Contents. ### Response: I. Introduction.


Instruction: What is the purpose of the 2014 Clinical Practice Guideline Recommendations?

Output: Recon ciling

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of the 2014 Clinical Practice Guideline Recommendations?. ### Response: Recon ciling.


Instruction: What is the scope of this Clinical Practice Guideline?

Output: 10 D. Scope

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the scope of this Clinical Practice Guideline?. ### Response: 10 D. Scope.


Instruction: What are the types of groups that are included in this Guideline that are excluded from this guideline? What is a summary of patient focus group methods and findings?

Output: Populations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the types of groups that are included in this Guideline that are excluded from this guideline? What is a summary of patient focus group methods and findings?. ### Response: Populations.


Instruction: What is included in this Guideline?

Output: Populations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is included in this Guideline?. ### Response: Populations.


Instruction: What are Populations Excluded from?

Output: this Guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are Populations Excluded from?. ### Response: this Guideline.


Instruction: How is patient centered care defined?

Output: Patient -centered Care  ....................................................................................................................... 11 F. Highl ighted Features of this Clinical Practice Guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is patient centered care defined?. ### Response: Patient -centered Care  ....................................................................................................................... 11 F. Highl ighted Features of this Clinical Practice Guideline.


Instruction: What does Treatment Intensity Instead of Lipid Targets do?

Output: Shared Decision Making

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Treatment Intensity Instead of Lipid Targets do?. ### Response: Shared Decision Making.


Instruction: What is the name of the group that makes the guideline?

Output: Guideline Wo rk Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that makes the guideline?. ### Response: Guideline Wo rk Group.


Instruction: What has been reported with immunosuppressive therapy in a number of patients?

Output: a worsening of VA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been reported with immunosuppressive therapy in a number of patients?. ### Response: a worsening of VA.


Instruction: How long after initiating therapy has electri-cal storm developed?

Output: 12 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after initiating therapy has electri-cal storm developed?. ### Response: 12 months.


Instruction: What did one study report a decrease of with steroid ther -apy?

Output: arrhythmia burden

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did one study report a decrease of with steroid ther -apy?. ### Response: arrhythmia burden.


Instruction: What did not experience benefit from steroid ther -apy?

Output: those with advanced LV dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did not experience benefit from steroid ther -apy?. ### Response: those with advanced LV dysfunction.


Instruction: What percentage of patients were successful in a systematic combined treatment approach?

Output: 63%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients were successful in a systematic combined treatment approach?. ### Response: 63%.


Instruction: In a series that included both steroids and antiarrhythmic medications, what was successful in 63% of patients?

Output: A systematic combined treatment approach

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In a series that included both steroids and antiarrhythmic medications, what was successful in 63% of patients?. ### Response: A systematic combined treatment approach.


Instruction: What did ther -apy include?

Output: steroids and antiarrhythmic medications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did ther -apy include?. ### Response: steroids and antiarrhythmic medications.


Instruction: What was followed by radiofrequency cath-eter ablation if needed?

Output: steroids and antiarrhythmic medications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was followed by radiofrequency cath-eter ablation if needed?. ### Response: steroids and antiarrhythmic medications.


Instruction: Immunosuppressive therapy may serve a dual purpose beyond what?

Output: arrhythmia effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Immunosuppressive therapy may serve a dual purpose beyond what?. ### Response: arrhythmia effects.


Instruction: What has yet to be demonstrated in RCTs?

Output: Immunosuppressive therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has yet to be demonstrated in RCTs?. ### Response: Immunosuppressive therapy.


Instruction: Steroids do not appear to reverse what once present?

Output: advanced ventricular dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Steroids do not appear to reverse what once present?. ### Response: advanced ventricular dysfunction.


Instruction: What supports the importance of early diagnosis and intervention?

Output: Steroids do not appear to reverse advanced ventricular dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What supports the importance of early diagnosis and intervention?. ### Response: Steroids do not appear to reverse advanced ventricular dysfunction.


Instruction: S7.6-1 PET scanning is being increasingly used in what?

Output: sarcoidosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: S7.6-1 PET scanning is being increasingly used in what?. ### Response: sarcoidosis.


Instruction: What is a heterogeneous group of uncommon systemic diseases with associat-ed cardiac involvement?

Output: Infiltrative cardiomyopathies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a heterogeneous group of uncommon systemic diseases with associat-ed cardiac involvement?. ### Response: Infiltrative cardiomyopathies.


Instruction: Infiltrative cardiomyopathies, such as Fabry's disease, VAs are what?

Output: uncommon

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Infiltrative cardiomyopathies, such as Fabry's disease, VAs are what?. ### Response: uncommon.


Instruction: What is highly treatable especially?

Output: hemochromatosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is highly treatable especially?. ### Response: hemochromatosis.


Instruction: What is a highly treatable condition?

Output: hemochromatosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a highly treatable condition?. ### Response: hemochromatosis.


Instruction: What must accompany management of cardiac arrhythmias?

Output: treat-ment of the underlying condition

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must accompany management of cardiac arrhythmias?. ### Response: treat-ment of the underlying condition.


Instruction: Most studies of infiltrative cardiomyopathies are small and what?

Output: observational

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Most studies of infiltrative cardiomyopathies are small and what?. ### Response: observational.


Instruction: What should VAs be treated as in any other cardiomyopathy?

Output: unless contraindications are present

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should VAs be treated as in any other cardiomyopathy?. ### Response: unless contraindications are present.


Instruction: See Section 7.6 for what?

Output: sarcoidosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: See Section 7.6 for what?. ### Response: sarcoidosis.


Instruction: Until recently, what was associated with a very poor prognosis?

Output: cardiac amyloidosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Until recently, what was associated with a very poor prognosis?. ### Response: cardiac amyloidosis.


Instruction: What have advances in medical therapy for light-chain amyloidosis led to?

Output: improved outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have advances in medical therapy for light-chain amyloidosis led to?. ### Response: improved outcomes.


Instruction: Why are decisions must be individualized?

Output: data remain too limited to al-low formal recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why are decisions must be individualized?. ### Response: data remain too limited to al-low formal recommendations.


Instruction: What are published reports on ICD effectiveness small, observa-tional and with limited follow up?

Output: amyloidosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are published reports on ICD effectiveness small, observa-tional and with limited follow up?. ### Response: amyloidosis.


Instruction: What type of amyloidosis is more likely to benefit from ICD placement than transthyreitin-related?

Output: light chain

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of amyloidosis is more likely to benefit from ICD placement than transthyreitin-related?. ### Response: light chain.


Instruction: What is the rate of VA in light chain amyloidosis?

Output: greater

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the rate of VA in light chain amyloidosis?. ### Response: greater.


Instruction: When was this article downloaded?

Output: April 23, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this article downloaded?. ### Response: April 23, 2023.


Instruction: How many patients were enrolled in a recent study in Japan?

Output: 2539

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were enrolled in a recent study in Japan?. ### Response: 2539.


Instruction: How many institutions in Japan enrolled patients with type 2 diabetes mellitus and no history of atherosclerotic vascular disease?

Output: 163

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many institutions in Japan enrolled patients with type 2 diabetes mellitus and no history of atherosclerotic vascular disease?. ### Response: 163.


Instruction: How many atherosclerotic vascu-lar events occurred over the course of 4.37 years?

Output: 154

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many atherosclerotic vascu-lar events occurred over the course of 4.37 years?. ### Response: 154.


Instruction: How many events occurred in the aspirin group?

Output: 68

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many events occurred in the aspirin group?. ### Response: 68.


Instruction: What was the HR of the nonaspirin groups?

Output: 0.80

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the HR of the nonaspirin groups?. ### Response: 0.80.


Instruction: When did a single fatal stroke occur?

Output: in the aspirin group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did a single fatal stroke occur?. ### Response: in the aspirin group.


Instruction: How many strokes occurred in the nonaspirin group?

Output: 5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes occurred in the nonaspirin group?. ### Response: 5.


Instruction: What has been included in a number of large primary prevention trials?

Output: subgroup analyses of patients with diabetes mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been included in a number of large primary prevention trials?. ### Response: subgroup analyses of patients with diabetes mellitus.


Instruction: How many randomized trials did the Antithrombotic Trialists' Collaboration report on the effects of antiplatelet therapy versus control?

Output: 287

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many randomized trials did the Antithrombotic Trialists' Collaboration report on the effects of antiplatelet therapy versus control?. ### Response: 287.


Instruction: What was the nonsignificant reduction in serious vascular events in the subgroup of 5126 patients with diabetes mellitus?

Output: 7%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the nonsignificant reduction in serious vascular events in the subgroup of 5126 patients with diabetes mellitus?. ### Response: 7%.


Instruction: How many patients with diabetes mellitus had stroke?

Output: 5126

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with diabetes mellitus had stroke?. ### Response: 5126.


Instruction: How many studies were included in the anal-ysis?

Output: 11 618

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were included in the anal-ysis?. ### Response: 11 618.


Instruction: How many participants were included in the anal-ysis?

Output: 11 618

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many participants were included in the anal-ysis?. ### Response: 11 618.


Instruction: The overall relative risk for major cardiovascular events was what?

Output: 0.91

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The overall relative risk for major cardiovascular events was what?. ### Response: 0.91.


Instruction: What was not found?

Output: an effect on stroke incidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not found?. ### Response: an effect on stroke incidence.


Instruction: Why is hyper-glycemia important in patients?

Output: reduces platelet sensitivity to aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is hyper-glycemia important in patients?. ### Response: reduces platelet sensitivity to aspirin.


Instruction: What reduces platelet sensitivity to aspirin?

Output: hyper -glycemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What reduces platelet sensitivity to aspirin?. ### Response: hyper -glycemia.


Instruction: What is an important consideration in patients with diabetes mellitus?

Output: aspirin dose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an important consideration in patients with diabetes mellitus?. ### Response: aspirin dose.


Instruction: In a meta-analysis, there was no evidence that what did not explain the lack of an aspirine effect on cardiovascular and stroke mortality?

Output: aspirin dose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In a meta-analysis, there was no evidence that what did not explain the lack of an aspirine effect on cardiovascular and stroke mortality?. ### Response: aspirin dose.


Instruction: The systematic review identified what?

Output: an important gap in random-ized, controlled trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The systematic review identified what?. ### Response: an important gap in random-ized, controlled trials.


Instruction: How much aspirin is used daily in patients with diabetes mellitus?

Output: 101 to 325 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much aspirin is used daily in patients with diabetes mellitus?. ### Response: 101 to 325 mg.


Instruction: What is a comprehensive program that includes tight control of hyper -tension with ACEI or ARB treatment?

Output: Diabetes: Summary and Gaps

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a comprehensive program that includes tight control of hyper -tension with ACEI or ARB treatment?. ### Response: Diabetes: Summary and Gaps.


Instruction: Hyper -tension with ACEI or ARB treatment reduces the risk of what in people with diabetes mellitus?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hyper -tension with ACEI or ARB treatment reduces the risk of what in people with diabetes mellitus?. ### Response: stroke.


Instruction: Glycemic control reduces microvascular complications, but there is no evidence that improved glycemic control does what?

Output: reduces the risk of incident stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Glycemic control reduces microvascular complications, but there is no evidence that improved glycemic control does what?. ### Response: reduces the risk of incident stroke.