Instruction: AHA Nutrition Committee. 1998;97:2099–2100.

Output: Noise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: AHA Nutrition Committee. 1998;97:2099–2100.. ### Response: Noise.


Instruction: Okorodudu DO, Jumean MF, Montori VM, Romero-Corral A, What?

Output: Somers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Okorodudu DO, Jumean MF, Montori VM, Romero-Corral A, What?. ### Response: Somers.


Instruction: How many potential strategies are there for anticoagulation?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many potential strategies are there for anticoagulation?. ### Response: 3.


Instruction: What are the three potential strategies?

Output: Continue warfa-rin throughout pregnancy; 2) use heparin throughout pregnancy; and 3) use sequential therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the three potential strategies?. ### Response: Continue warfa-rin throughout pregnancy; 2) use heparin throughout pregnancy; and 3) use sequential therapy.


Instruction: When is heparin used?

Output: throughout pregnancy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is heparin used?. ### Response: throughout pregnancy.


Instruction: Where is warfarin used during the second and third trimesters?

Output: sequential therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is warfarin used during the second and third trimesters?. ### Response: sequential therapy.


Instruction: What is the risk of catastrophic valve failure or stroke for women with mechanical heart valves?

Output: prohibitively high

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of catastrophic valve failure or stroke for women with mechanical heart valves?. ### Response: prohibitively high.


Instruction: What is a major cause of maternal morbidity and mortality during pregnancy?

Output: women who are not receiving appropriate doses of anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a major cause of maternal morbidity and mortality during pregnancy?. ### Response: women who are not receiving appropriate doses of anticoagulation.


Instruction: What is the cause of maternal morbidity and mortality during pregnancy?

Output: women who are not receiving appropriate doses of anticoagulation because of improper administration, improper monitoring, or medication nonadherence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cause of maternal morbidity and mortality during pregnancy?. ### Response: women who are not receiving appropriate doses of anticoagulation because of improper administration, improper monitoring, or medication nonadherence.


Instruction: What are women who are not receiving appropriate doses of anticoagulation at risk for?

Output: maternal morbidity and mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are women who are not receiving appropriate doses of anticoagulation at risk for?. ### Response: maternal morbidity and mortality.


Instruction: What is a prohibitive risk for pregnancy?

Output: Women who are not able to receive therapeutic anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a prohibitive risk for pregnancy?. ### Response: Women who are not able to receive therapeutic anticoagulation.


Instruction: No anticoagulation strategy is optimally safe for both the mother and the fetus?

Output: 13–153

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No anticoagulation strategy is optimally safe for both the mother and the fetus?. ### Response: 13–153.


Instruction: What does Warfarin cross the placenta and cause?

Output: fetal intracranial hemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Warfarin cross the placenta and cause?. ### Response: fetal intracranial hemorrhage.


Instruction: What does UFH and LMWH cross the placenta but are associated with higher rates of?

Output: maternal complications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does UFH and LMWH cross the placenta but are associated with higher rates of?. ### Response: maternal complications.


Instruction: What is the dose needed to maintain a therapeutic INR during pregnancy?

Output: warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the dose needed to maintain a therapeutic INR during pregnancy?. ### Response: warfarin.


Instruction: What is associated with higher rates of maternal complications than is seen with war -farin?

Output: Neither UFH nor LMWH crosses the placenta

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with higher rates of maternal complications than is seen with war -farin?. ### Response: Neither UFH nor LMWH crosses the placenta.


Instruction: What is an antico-agulation strategy that minimizes maternal risk?

Output: warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an antico-agulation strategy that minimizes maternal risk?. ### Response: warfarin.


Instruction: What does counseling and shared decision-making allow a woman and her physician to do?

Output: choose the best anticoagula-tion to achieve the woman’s goals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does counseling and shared decision-making allow a woman and her physician to do?. ### Response: choose the best anticoagula-tion to achieve the woman’s goals.


Instruction: What should physicians not assume or supplant their own preferences for?

Output: those of the patient

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should physicians not assume or supplant their own preferences for?. ### Response: those of the patient.


Instruction: What does warfarin do to the fetus and the mother?

Output: anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does warfarin do to the fetus and the mother?. ### Response: anticoagulation.


Instruction: What is the risk of fetal intracranial hemorrhage if the mother is fully antico-agulated with warfarine during vaginal delivery?

Output: higher risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of fetal intracranial hemorrhage if the mother is fully antico-agulated with warfarine during vaginal delivery?. ### Response: higher risk.


Instruction: When is the mother fully antico-agulated with warfarin during vaginal delivery?

Output: during the sec-ond and third trimesters

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is the mother fully antico-agulated with warfarin during vaginal delivery?. ### Response: during the sec-ond and third trimesters.


Instruction: What can women take to minimize the risk of coagulation for pregnant women?

Output: warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can women take to minimize the risk of coagulation for pregnant women?. ### Response: warfarin.


Instruction: What is the risk of recurrent stroke in patients with sickle cell disease treated with erythrocyte transfusions?

Output: 896–899

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of recurrent stroke in patients with sickle cell disease treated with erythrocyte transfusions?. ### Response: 896–899.


Instruction: When did J Pediatr. 1995:126:896-899?

Output: 1995

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J Pediatr. 1995:126:896-899?. ### Response: 1995.


Instruction: What is blood transfusion for preventing?

Output: primary and secondary stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is blood transfusion for preventing?. ### Response: primary and secondary stroke.


Instruction: What prevents primary and secondary stroke in people with sickle cell disease?

Output: Blood trans-fusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What prevents primary and secondary stroke in people with sickle cell disease?. ### Response: Blood trans-fusion.


Instruction: What does SWiTCH Investigators do?

Output: Stroke With Transfusions Changing to Hydroxyurea

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does SWiTCH Investigators do?. ### Response: Stroke With Transfusions Changing to Hydroxyurea.


Instruction: When did Blood. 2012;119:3925-3932. doi: 10.1182/blood-2011-11-392340 660?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Blood. 2012;119:3925-3932. doi: 10.1182/blood-2011-11-392340 660?. ### Response: 2012.


Instruction: What is the name of the drug used to treat stroke recurrence in children with sickle cell disease?

Output: hydroxyurea

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used to treat stroke recurrence in children with sickle cell disease?. ### Response: hydroxyurea.


Instruction: When was the first clinical stroke treated with hydroxyurea?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the first clinical stroke treated with hydroxyurea?. ### Response: 2011.


Instruction: How many strokes were there in 2011?

Output: 660

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes were there in 2011?. ### Response: 660.


Instruction: What is the name of the multicentre, open-label, non-inferiority trial?

Output: TCD With Transfusions Changing to Hydroxyurea (TWiTCH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multicentre, open-label, non-inferiority trial?. ### Response: TCD With Transfusions Changing to Hydroxyurea (TWiTCH.


Instruction: What is TCD With Transfusions Changing to Hydroxyurea?

Output: TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is TCD With Transfusions Changing to Hydroxyurea?. ### Response: TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial.


Instruction: What is the name of the non-inferiority trial?

Output: TCD With Transfusions Changing to Hydroxyurea (TWiTCH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the non-inferiority trial?. ### Response: TCD With Transfusions Changing to Hydroxyurea (TWiTCH.


Instruction: When was the Lancet 387:661–670 published?

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Lancet 387:661–670 published?. ### Response: 2016.


Instruction: What is a possible outcome of allogeneic cellular gene therapy in hemoglobinopathies?

Output: hematopoietic SCT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a possible outcome of allogeneic cellular gene therapy in hemoglobinopathies?. ### Response: hematopoietic SCT.


Instruction: What is the name of the multicenter investigation of bone marrow transplantation for sickle cell disease?

Output: Bone Marrow Transplant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multicenter investigation of bone marrow transplantation for sickle cell disease?. ### Response: Bone Marrow Transplant.


Instruction: What type of hematopoietic chimerism after bone transplantation?

Output: mixed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of hematopoietic chimerism after bone transplantation?. ### Response: mixed.


Instruction: What type of anemia is treated with bone marrow transplantation?

Output: sickle cell

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of anemia is treated with bone marrow transplantation?. ### Response: sickle cell.


Instruction: What is the name of the procedure used to treat sickle cell anemia?

Output: EDAS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the procedure used to treat sickle cell anemia?. ### Response: EDAS.


Instruction: How many patients were treated with EDAS?

Output: 211 666

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with EDAS?. ### Response: 211 666.


Instruction: What is the name of the procedure that was performed after EDAS procedure?

Output: Bone Marrow Transplantation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the procedure that was performed after EDAS procedure?. ### Response: Bone Marrow Transplantation.


Instruction: What was the title of the paper that was published in 2003?

Output: Pediatr Neurol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the title of the paper that was published in 2003?. ### Response: Pediatr Neurol.


Instruction: How was the outcome of the surgical treatment of moyamoya syndrome?

Output: outcome following encephaloduroarte-riosynangiosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the outcome of the surgical treatment of moyamoya syndrome?. ### Response: outcome following encephaloduroarte-riosynangiosis.


Instruction: What is a moving target in Epidemiology?

Output: Pleasants S

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a moving target in Epidemiology?. ### Response: Pleasants S.


Instruction: What is the name of the disease that causes Sickle cell disease?

Output: moyamoya

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease that causes Sickle cell disease?. ### Response: moyamoya.


Instruction: When did the Lancet publish 390:311-323?

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Lancet publish 390:311-323?. ### Response: 2017.


Instruction: What is the global epidemiology of sickle haemoglobin in neonates?

Output: a contemporary geostatistical model-based map and population estimates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the global epidemiology of sickle haemoglobin in neonates?. ### Response: a contemporary geostatistical model-based map and population estimates.


Instruction: What is a contemporary geostatistical model-based map and population estimates?

Output: Global epidemiology of sickle haemoglobin in neonates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a contemporary geostatistical model-based map and population estimates?. ### Response: Global epidemiology of sickle haemoglobin in neonates.


Instruction: What is aSAH in patients with aneurysms of the basilar apex?

Output: Class IIb

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is aSAH in patients with aneurysms of the basilar apex?. ### Response: Class IIb.


Instruction: What is the class IIb; Level of Evidence C?

Output: basilar apex

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the class IIb; Level of Evidence C?. ### Response: basilar apex.


Instruction: Stenting is associated with increased morbidity and what else?

Output: higher mortality rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Stenting is associated with increased morbidity and what else?. ### Response: higher mortality rates.


Instruction: What type of options have been excluded?

Output: less risky options

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of options have been excluded?. ### Response: less risky options.


Instruction: How many nontraumatic cases of aSAH were studied in the US from 2003?

Output: 31 476

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many nontraumatic cases of aSAH were studied in the US from 2003?. ### Response: 31 476.


Instruction: What was delivered in less than one third of the cases?

Output: ysm repair

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was delivered in less than one third of the cases?. ### Response: ysm repair.


Instruction: What were the adjusted odds of definitiverepair in urban teaching hospitals?

Output: higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the adjusted odds of definitiverepair in urban teaching hospitals?. ### Response: higher.


Instruction: What was the odds ratio in ruralhospitals?

Output: 3.08

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the odds ratio in ruralhospitals?. ### Response: 3.08.


Instruction: Between 1993 and 2003, teaching status and larger hospital size were associated with higher charges and longer stay but also with what?

Output: betteroutcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Between 1993 and 2003, teaching status and larger hospital size were associated with higher charges and longer stay but also with what?. ### Response: betteroutcomes.


Instruction: What was more often used in the elderly?

Output: Endovascular treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was more often used in the elderly?. ### Response: Endovascular treatment.


Instruction: What was associated with significantly higher mortality rates in smaller hospitals?

Output: Endovascular treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with significantly higher mortality rates in smaller hospitals?. ### Response: Endovascular treatment.


Instruction: What percentage of US hospitals admitted /H1102119 patients withaSAH annually?

Output: 82%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of US hospitals admitted /H1102119 patients withaSAH annually?. ### Response: 82%.


Instruction: What was the 30-day mortality rate signifi-cantly higher in hospitals that admitted patients that had a SAH than those that did not?

Output: /H1102110

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 30-day mortality rate signifi-cantly higher in hospitals that admitted patients that had a SAH than those that did not?. ### Response: /H1102110.


Instruction: Large academiccenters were associated with what type of results?

Output: better

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Large academiccenters were associated with what type of results?. ### Response: better.


Instruction: What percentage of hospitals admitted /H1102110 patients withaSAH?

Output: 39%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of hospitals admitted /H1102110 patients withaSAH?. ### Response: 39%.


Instruction: What was the Odds ratio?

Output: 1.4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the Odds ratio?. ### Response: 1.4.


Instruction: How many factors were associated with better outcomes?

Output: teaching status and larger hospital size

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many factors were associated with better outcomes?. ### Response: teaching status and larger hospital size.


Instruction: Institutions that used endovascular coil embolization more frequently had what?

Output: lower in-hospital mortality rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Institutions that used endovascular coil embolization more frequently had what?. ### Response: lower in-hospital mortality rates.


Instruction: What was the reduction in risk forevery 10% of cases treated?

Output: 9%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the reduction in risk forevery 10% of cases treated?. ### Response: 9%.


Instruction: What did balloon angioplasty do to treat vasospasm?

Output: 16%reduction in risk of in-hospital death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did balloon angioplasty do to treat vasospasm?. ### Response: 16%reduction in risk of in-hospital death.


Instruction: What are important determinants of improved outcomes in aSAH?

Output: treatment vol-umes and availability of both endovascular and neurologicalintensive care services at hospitals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are important determinants of improved outcomes in aSAH?. ### Response: treatment vol-umes and availability of both endovascular and neurologicalintensive care services at hospitals.


Instruction: How much would transferring a patient with ASD from a low- to a high-volume hospital cost?

Output: $10 548

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much would transferring a patient with ASD from a low- to a high-volume hospital cost?. ### Response: $10 548.


Instruction: How many quality-adjusted life-years did the inten-tive care specialists gain at a cost of $10 548.162,163?

Output: 1.6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many quality-adjusted life-years did the inten-tive care specialists gain at a cost of $10 548.162,163?. ### Response: 1.6.


Instruction: One study suggested that care was uniformly delivered within an institution when what was compared with weekdayadmissions?

Output: weekend

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: One study suggested that care was uniformly delivered within an institution when what was compared with weekdayadmissions?. ### Response: weekend.


Instruction: What did not depend on the quality of the supporting data?

Output: inten-sive care specialists followed evidence-based recommenda-tions very inconsistently, and these variations in practice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did not depend on the quality of the supporting data?. ### Response: inten-sive care specialists followed evidence-based recommenda-tions very inconsistently, and these variations in practice.


Instruction: AHA/ACCF Secondary Prevention and Risk ReductionTherapy for Patients With Coronary and OtherAtherosclerotic Vascular Disease: 2011 UpdateA Guideline From the American Heart Association and American Collegeof Cardiology FoundationA guideline from the World Heart Federation and the Preventive Ca rdiovascular Nurses AssociationSidney C. Smith, Jr, MD, FAHA, FACC, Chair; Emelia J. Benjami

Output: “Secondary Prevention and Risk Reduction Therapy for Patie ntsWith Coronary and Other Atherosclerotic Vascular Disease. ”

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: AHA/ACCF Secondary Prevention and Risk ReductionTherapy for Patients With Coronary and OtherAtherosclerotic Vascular Disease: 2011 UpdateA Guideline From the American Heart Association and American Collegeof Cardiology FoundationA guideline from the World Heart Federation and the Preventive Ca rdiovascular Nurses AssociationSidney C. Smith, Jr, MD, FAHA, FACC, Chair; Emelia J. Benjami. ### Response: “Secondary Prevention and Risk Reduction Therapy for Patie ntsWith Coronary and Other Atherosclerotic Vascular Disease. ”.


Instruction: Who is C. Smith, Jr.?

Output: Sidney

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is C. Smith, Jr.?. ### Response: Sidney.


Instruction: Who is Emelia J. Benjami n, MD, ScM, FAHA, FACC?

Output: Sidney C. Smith, Jr, MD, FAHA, FACC, Chair

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Emelia J. Benjami n, MD, ScM, FAHA, FACC?. ### Response: Sidney C. Smith, Jr, MD, FAHA, FACC, Chair.


Instruction: What is Scott M. Grundy's profession?

Output: MD, PhD, FAHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Scott M. Grundy's profession?. ### Response: MD, PhD, FAHA.


Instruction: What is Loren F. Hiratzka's career?

Output: MD, FAHA, FACC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Loren F. Hiratzka's career?. ### Response: MD, FAHA, FACC.


Instruction: Who is Daniel W. Jones?

Output: MD, FAHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Daniel W. Jones?. ### Response: MD, FAHA.


Instruction: Where is Margo Minissian?

Output: ACNP, AACC, FAHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Margo Minissian?. ### Response: ACNP, AACC, FAHA.


Instruction: What is the acronym for the American Heart Association/ACCF guidelines on secondary prevention?

Output: FAHAS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the American Heart Association/ACCF guidelines on secondary prevention?. ### Response: FAHAS.


Instruction: Who is the MD, MPH, FAHA, FAC C?

Output: John Spertus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the MD, MPH, FAHA, FAC C?. ### Response: John Spertus.


Instruction: What has emerged from clinical trials that further support the merits of intensive risk-reduction therapies for patients with established coronary and other atherosclero ticvascular disease?

Output: evi-dence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has emerged from clinical trials that further support the merits of intensive risk-reduction therapies for patients with established coronary and other atherosclero ticvascular disease?. ### Response: evi-dence.


Instruction: What does the writing group believe would be more appropriate to expand the title of this guideli ne to?

Output: “Secondary Prevention and Risk Reduction Therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the writing group believe would be more appropriate to expand the title of this guideli ne to?. ### Response: “Secondary Prevention and Risk Reduction Therapy.


Instruction: The growing body of evidence confirms that in what?

Output: patien tswith atherosclerotic vascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The growing body of evidence confirms that in what?. ### Response: patien tswith atherosclerotic vascular disease.


Instruction: What does the growing body of evidence confirm in patien tswith atherosclerotic vascular disease?

Output: comprehensive ris k factormanagement reduces risk as assessed by a variety of outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the growing body of evidence confirm in patien tswith atherosclerotic vascular disease?. ### Response: comprehensive ris k factormanagement reduces risk as assessed by a variety of outcomes.


Instruction: What reduces risk as assessed by a variety of outcomes?

Output: comprehensive ris k factormanagement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What reduces risk as assessed by a variety of outcomes?. ### Response: comprehensive ris k factormanagement.


Instruction: What is important not only for the healthcare provider but also tha thealthcare systems support?

Output: recommendations in appropriate patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is important not only for the healthcare provider but also tha thealthcare systems support?. ### Response: recommendations in appropriate patients.


Instruction: What provides the impetus for thi supdate of the recommendations?

Output: clinical trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What provides the impetus for thi supdate of the recommendations?. ### Response: clinical trials.


Instruction: What format are the classification of recommendations and level of evidence expressed in?

Output: ACCF/AHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What format are the classification of recommendations and level of evidence expressed in?. ### Response: ACCF/AHA.


Instruction: Recommendations made herein are largely based on what?

Output: major practice guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Recommendations made herein are largely based on what?. ### Response: major practice guidelines.


Instruction: Where did the National Institutes of Health update ACCF/AHA practice guidelines?

Output: 2006 update of the American Heart Association(AHA)/American College of Cardiology Foundation(ACCF) guidelines on secondary prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where did the National Institutes of Health update ACCF/AHA practice guidelines?. ### Response: 2006 update of the American Heart Association(AHA)/American College of Cardiology Foundation(ACCF) guidelines on secondary prevention.


Instruction: What did the development of the present guideline involve?

Output: clinical trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the development of the present guideline involve?. ### Response: clinical trials.


Instruction: What is a common abnormality in children with CKD?

Output: hypertriglyceridemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a common abnormality in children with CKD?. ### Response: hypertriglyceridemia.


Instruction: What should clinicians measure at baseline to screen for underlying causes of dyslipidemia?

Output: lipid levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should clinicians measure at baseline to screen for underlying causes of dyslipidemia?. ### Response: lipid levels.


Instruction: What are children with CKD less concerned about?

Output: the possibility of adverse events or inconvenienceassociated with baseline measurement of lipid levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are children with CKD less concerned about?. ### Response: the possibility of adverse events or inconvenienceassociated with baseline measurement of lipid levels.


Instruction: What is minimally invasive, relatively inexpensive, and has potential to improve?

Output: growth and development

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is minimally invasive, relatively inexpensive, and has potential to improve?. ### Response: growth and development.


Instruction: What is less concerned about the possibility of adverse events or inconvenience associated with baseline measurement of lipid levels?

Output: children with CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is less concerned about the possibility of adverse events or inconvenience associated with baseline measurement of lipid levels?. ### Response: children with CKD.


Instruction: What justify astrong recommendation despite the low quality of theavailable evidence?

Output: children with CKD (and their families) place ahigh value on this potential beneﬁt and are less concernedabout the possibility of adverse events or inconvenienceassociated with baseline measurement of lipid levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What justify astrong recommendation despite the low quality of theavailable evidence?. ### Response: children with CKD (and their families) place ahigh value on this potential beneﬁt and are less concernedabout the possibility of adverse events or inconvenienceassociated with baseline measurement of lipid levels.


Instruction: In children with CKD, we suggestannual follow-up measurement of what?

Output: fasting lipid levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In children with CKD, we suggestannual follow-up measurement of what?. ### Response: fasting lipid levels.


Instruction: What do we suggest for children with CKD?

Output: annual follow-up measurement of fasting lipid levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do we suggest for children with CKD?. ### Response: annual follow-up measurement of fasting lipid levels.


Instruction: How often do data document clinical lipid statuschanges in children?

Output: annually

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often do data document clinical lipid statuschanges in children?. ### Response: annually.


Instruction: Growth and development in children havepotential to influence what?

Output: lipid metabolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Growth and development in children havepotential to influence what?. ### Response: lipid metabolism.


Instruction: What is the ideal frequency of follow-up for fasting levels ofLDL-C?

Output: unknown

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ideal frequency of follow-up for fasting levels ofLDL-C?. ### Response: unknown.


Instruction: What do children with CKD need to follow to screen for secondary causes of dyslipidemia?

Output: fasting lipid levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do children with CKD need to follow to screen for secondary causes of dyslipidemia?. ### Response: fasting lipid levels.


Instruction: What is unknown in most children with CKD?

Output: The ideal frequency of follow-up for fasting levels ofLDL-C, HDL-C and serum TGs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is unknown in most children with CKD?. ### Response: The ideal frequency of follow-up for fasting levels ofLDL-C, HDL-C and serum TGs.


Instruction: How often can HDL-C and serum TGs be assessed?

Output: annually

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often can HDL-C and serum TGs be assessed?. ### Response: annually.


Instruction: What is a possible change in management in response to measurements?

Output: therapeutic lifestyle measures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a possible change in management in response to measurements?. ### Response: therapeutic lifestyle measures.


Instruction: What could include therapeutic lifestyle measures or statin regimens for children?

Output: Possible changesin management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could include therapeutic lifestyle measures or statin regimens for children?. ### Response: Possible changesin management.


Instruction: What should be used for children with very high LDL-Clevels?

Output: statin regimens

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be used for children with very high LDL-Clevels?. ### Response: statin regimens.


Instruction: What is common in children with CKD?

Output: Dyslipidemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is common in children with CKD?. ### Response: Dyslipidemia.


Instruction: Who should be screened for dyslipide-mias at presentation?

Output: All children with CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should be screened for dyslipide-mias at presentation?. ### Response: All children with CKD.


Instruction: What should children with CKD be screened for at presentation?

Output: dyslipide-mias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should children with CKD be screened for at presentation?. ### Response: dyslipide-mias.


Instruction: Because growth and development and modalityswitches may influence lipid metabolism, lipids could be evaluated when what?

Output: annually

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Because growth and development and modalityswitches may influence lipid metabolism, lipids could be evaluated when what?. ### Response: annually.


Instruction: What should be conducted to determine the prevalence of dyslipidemias among children initiating dialysis or receiving a kidney transplant?

Output: Future studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be conducted to determine the prevalence of dyslipidemias among children initiating dialysis or receiving a kidney transplant?. ### Response: Future studies.


Instruction: To determine the prevalence of dyslipidemias among children initiating dialysis or receiving a kidney transplant?

Output: Future studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: To determine the prevalence of dyslipidemias among children initiating dialysis or receiving a kidney transplant?. ### Response: Future studies.


Instruction: To ensure that no inaccurate or misleading data appears in this Journal, publishers, editorialboard, and ISN do what?

Output: every effort

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: To ensure that no inaccurate or misleading data appears in this Journal, publishers, editorialboard, and ISN do what?. ### Response: every effort.


Instruction: What is reasonable in patients with SVT who are undergoing surgical repair of Ebstein anomaly?

Output: Preoperative catheter ablation or intraoperative surgical ablation of accessory pathways

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable in patients with SVT who are undergoing surgical repair of Ebstein anomaly?. ### Response: Preoperative catheter ablation or intraoperative surgical ablation of accessory pathways.


Instruction: What was the prevalence of SVT among patients with Ebston anomaly in 2016?

Output: 33%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the prevalence of SVT among patients with Ebston anomaly in 2016?. ### Response: 33%.


Instruction: When was the e552 Circulation?

Output: April 5, 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the e552 Circulation?. ### Response: April 5, 2016.


Instruction: What was the prevalence of SVT among patients with Ebstein anomaly in 1 large series?

Output: 33%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the prevalence of SVT among patients with Ebstein anomaly in 1 large series?. ### Response: 33%.


Instruction: What is the highest noted among ACHD patients?

Output: SVT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the highest noted among ACHD patients?. ### Response: SVT.


Instruction: AT, atrial flutter, or AF develops in  50% of patients with what condition?

Output: Ebstein anomaly

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: AT, atrial flutter, or AF develops in  50% of patients with what condition?. ### Response: Ebstein anomaly.


Instruction: What percentage of patients with Ebstein anomaly have right-sided accessory pathways?

Output: 15% to 30%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients with Ebstein anomaly have right-sided accessory pathways?. ### Response: 15% to 30%.


Instruction: What percent of patients may have multiple accessory pathways in up to  29% of those patients?

Output: 15% to 30%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percent of patients may have multiple accessory pathways in up to  29% of those patients?. ### Response: 15% to 30%.


Instruction: Catheter ablation of accessory pathways is associated with lower success rates than what other population?

Output: Ebstein anomaly

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Catheter ablation of accessory pathways is associated with lower success rates than what other population?. ### Response: Ebstein anomaly.


Instruction: What is the acute success rate of arrhythmia surgery?

Output: 75% to 89%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acute success rate of arrhythmia surgery?. ### Response: 75% to 89%.


Instruction: What percentage of procedures have an acute recurrence rate?

Output: 25% to 30%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of procedures have an acute recurrence rate?. ### Response: 25% to 30%..


Instruction: How many adults were undergoing surgery to repair an Ebstein anomaly?

Output: 83

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many adults were undergoing surgery to repair an Ebstein anomaly?. ### Response: 83.


Instruction: What percentage of Ebstein anomaly patients had accessory pathways?

Output: 15% to 30%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of Ebstein anomaly patients had accessory pathways?. ### Response: 15% to 30%.


Instruction: How many patients had atrial flutter/fibrillation after surgery?

Output: 54%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had atrial flutter/fibrillation after surgery?. ### Response: 54%,.


Instruction: In a series of patients undergoing right atrial maze procedures or isthmus ablation for AP, what has been reported in 92% to 100%?

Output: Successful surgical ablation of accessory pathways

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In a series of patients undergoing right atrial maze procedures or isthmus ablation for AP, what has been reported in 92% to 100%?. ### Response: Successful surgical ablation of accessory pathways.


Instruction: What percentage of patients were free from recurrent flutter/fibrillation during 34 months of follow-up?

Output: 75%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients were free from recurrent flutter/fibrillation during 34 months of follow-up?. ### Response: 75%.


Instruction: What was the difference between combined operative arrhythmia surgery with repair and catheter ablation?

Output: effective in 94% of cases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the difference between combined operative arrhythmia surgery with repair and catheter ablation?. ### Response: effective in 94% of cases.


Instruction: How many cases of Ebstein anomaly repair were successful with the combined approach?

Output: 94%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many cases of Ebstein anomaly repair were successful with the combined approach?. ### Response: 94%.


Instruction: What percentage of patients treated with the catheter approach alone were successful?

Output: 76%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients treated with the catheter approach alone were successful?. ### Response: 76%.


Instruction: How many patients were treated with catheter ablation followed by surgical repair?

Output: 83

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with catheter ablation followed by surgical repair?. ### Response: 83.


Instruction: Which approach was effective in 94% of cases?

Output: combined operative arrhythmia surgery with repair, versus catheter ablation followed by surgical repair, the combined approach

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which approach was effective in 94% of cases?. ### Response: combined operative arrhythmia surgery with repair, versus catheter ablation followed by surgical repair, the combined approach.


Instruction: Who had lower risk of SCD than patients without arrhythmia intervention?

Output: patients who underwent preoperative EP study with intraoperative ablation of arrhythmia substrate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who had lower risk of SCD than patients without arrhythmia intervention?. ### Response: patients who underwent preoperative EP study with intraoperative ablation of arrhythmia substrate.


Instruction: What has been demonstrated to be safe and effective in patients with Ebstein anomaly?

Output: an integrated approach of arrhythmia intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been demonstrated to be safe and effective in patients with Ebstein anomaly?. ### Response: an integrated approach of arrhythmia intervention.


Instruction: Oral beta blockers or what else?

Output: sotalol therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Oral beta blockers or what else?. ### Response: sotalol therapy.


Instruction: What can be useful for prevention of recurrent AT or atrial flutter in ACHD patients?

Output: Oral beta blockers or sotalol therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be useful for prevention of recurrent AT or atrial flutter in ACHD patients?. ### Response: Oral beta blockers or sotalol therapy.


Instruction: What may decrease catecholamine-related triggers and provide AV nodal blockade?

Output: Beta blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may decrease catecholamine-related triggers and provide AV nodal blockade?. ### Response: Beta blockers.


Instruction: What did one study of adults with transposition of the great arteries and prior atrial switch repairs demonstrate in 50% of patients?

Output: SVT preceding VT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did one study of adults with transposition of the great arteries and prior atrial switch repairs demonstrate in 50% of patients?. ### Response: SVT preceding VT.


Instruction: What was associated with decreased incidence of appropriate defibrillator shocks?

Output: use of beta-blocker medications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with decreased incidence of appropriate defibrillator shocks?. ### Response: use of beta-blocker medications.


Instruction: What is the incidence of appropriate defibrillator shocks?

Output: decreased

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the incidence of appropriate defibrillator shocks?. ### Response: decreased.


Instruction: What percentage of patients report freedom from recurrent AT during short-term follow-up?

Output: 41% to 46%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients report freedom from recurrent AT during short-term follow-up?. ### Response: 41% to 46%.


Instruction: What are the 2007 guidelines on perioperative cardiovascular evaluation and care for?

Output: noncardiac surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the 2007 guidelines on perioperative cardiovascular evaluation and care for?. ### Response: noncardiac surgery.


Instruction: Circulation. 2009;120:e169–276.1251.

Output: 2007 guidelines on perioperative cardiovascular evaluation and care fornoncardiac surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation. 2009;120:e169–276.1251.. ### Response: 2007 guidelines on perioperative cardiovascular evaluation and care fornoncardiac surgery.


Instruction: Automated quantification ofmyocardial perfusion SPECT using simplified normal limits.

Output: Slomka PJ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Automated quantification ofmyocardial perfusion SPECT using simplified normal limits.. ### Response: Slomka PJ.


Instruction: What is the name of the new iodinated tracers for nuclear cardiology?

Output: MIBG and BMIPP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the new iodinated tracers for nuclear cardiology?. ### Response: MIBG and BMIPP.


Instruction: What are the names of the two new traers?

Output: MIBG and BMIPP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the two new traers?. ### Response: MIBG and BMIPP.


Instruction: When was the latest incardiac CT?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the latest incardiac CT?. ### Response: 2011.


Instruction: What are MIBG and BMIPP used for in nuclear cardiology?

Output: Novel iodinated tracers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are MIBG and BMIPP used for in nuclear cardiology?. ### Response: Novel iodinated tracers.


Instruction: What is the J Nucl Cardiol. 2011;18:135–43.1255.

Output: Novel iodinated tracers, MIBG and BMIPP,for nuclear cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the J Nucl Cardiol. 2011;18:135–43.1255.. ### Response: Novel iodinated tracers, MIBG and BMIPP,for nuclear cardiology.


Instruction: What are the differences between conventio nal dualdetector anger camera imaging?

Output: High-speed myocardial per-fusion imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the differences between conventio nal dualdetector anger camera imaging?. ### Response: High-speed myocardial per-fusion imaging.


Instruction: What is the name of the integ ratedcadmium-zinc-telluride/64-slice CT device used for downstream resourceutilization?

Output: Fiechter M, Ghadri JR, Wolfrum M, et al. Downstream resourceutilization following hybrid cardiac imaging with an integ ratedcadmium-zinc-telluride/64-slice CT device. Eur J Nucl Med MolImaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the integ ratedcadmium-zinc-telluride/64-slice CT device used for downstream resourceutilization?. ### Response: Fiechter M, Ghadri JR, Wolfrum M, et al. Downstream resourceutilization following hybrid cardiac imaging with an integ ratedcadmium-zinc-telluride/64-slice CT device. Eur J Nucl Med MolImaging.


Instruction: When did Eur J Nucl Med MolImaging issue 39:430–6.1257?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Eur J Nucl Med MolImaging issue 39:430–6.1257?. ### Response: 2011.


Instruction: What did Murthy VL, Naya M, Foster C, et al. measure with noninvasive measures of coronary flow reserve?

Output: Improved cardiac ri skassessment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Murthy VL, Naya M, Foster C, et al. measure with noninvasive measures of coronary flow reserve?. ### Response: Improved cardiac ri skassessment.


Instruction: What is a sensitive tool for the detection of myocardial ischemia?

Output: Speckle tracking echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a sensitive tool for the detection of myocardial ischemia?. ### Response: Speckle tracking echocardiography.


Instruction: What is the Incremental value of–dimensionalspeckle tracking?

Output: strain imaging to wall motion analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Incremental value of–dimensionalspeckle tracking?. ### Response: strain imaging to wall motion analysis.


Instruction: What is the incremental value of–dimensionalspeckle tracking strain imaging to wall motion analysis for?

Output: detection ofcoronary artery disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the incremental value of–dimensionalspeckle tracking strain imaging to wall motion analysis for?. ### Response: detection ofcoronary artery disease.


Instruction: What is done in patients undergoing dobutamine stress echo-cardiography?

Output: strain imaging to wall motion analysis for detection ofcoronary artery disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is done in patients undergoing dobutamine stress echo-cardiography?. ### Response: strain imaging to wall motion analysis for detection ofcoronary artery disease.


Instruction: In what year was Am Heart J 158:836–44.1260 published?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was Am Heart J 158:836–44.1260 published?. ### Response: 2009.


Instruction: What is detected with a real-time perfusion echocardiograph duringregadenoson stress?

Output: coronaryartery stenoses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is detected with a real-time perfusion echocardiograph duringregadenoson stress?. ### Response: coronaryartery stenoses.


Instruction: Ingkanisorn WP, Kwong RY, Bohme NS, et al. Prognosis of what in patients presentin g to anemergency department with chest pain?

Output: negativeadenosine stress magnetic resonance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Ingkanisorn WP, Kwong RY, Bohme NS, et al. Prognosis of what in patients presentin g to anemergency department with chest pain?. ### Response: negativeadenosine stress magnetic resonance.


Instruction: What is the name of the imaging technique used to detect acute coronarysyndrome in the emergency department?

Output: cardiac magnetic res-onance imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the imaging technique used to detect acute coronarysyndrome in the emergency department?. ### Response: cardiac magnetic res-onance imaging.


Instruction: When was cardiac magnetic resonance imaging first used?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was cardiac magnetic resonance imaging first used?. ### Response: 2003.


Instruction: How long did it take to detect myo-cardial infarction?

Output: Rapid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take to detect myo-cardial infarction?. ### Response: Rapid.


Instruction: What is a comparison with 1.–tesla for the detection of coronaryartery disease?

Output: Cardiovascular magneticresonance perfusion imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a comparison with 1.–tesla for the detection of coronaryartery disease?. ### Response: Cardiovascular magneticresonance perfusion imaging.


Instruction: What is the diagnostic accuracy of 1.–Tesla?

Output: T

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the diagnostic accuracy of 1.–Tesla?. ### Response: T.


Instruction: Who spoke about their current involvement in the care of people with HF?

Output: The GP members of the committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who spoke about their current involvement in the care of people with HF?. ### Response: The GP members of the committee.


Instruction: What did the GP members of the committee speak about?

Output: their current involvement in the care of people with HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the GP members of the committee speak about?. ### Response: their current involvement in the care of people with HF.


Instruction: What was one of the most difficult conditions to manage for people with HF?

Output: Chronic Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was one of the most difficult conditions to manage for people with HF?. ### Response: Chronic Heart Failure.


Instruction: What type of HF patients tend to have multiple?

Output: complex comorbidities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of HF patients tend to have multiple?. ### Response: complex comorbidities.


Instruction: What type of comorbidities do people with HF tend to have?

Output: housebound

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of comorbidities do people with HF tend to have?. ### Response: housebound.


Instruction: What did the committee think about when thinking about reviewing and co-ordinating care?

Output: including aspects of the multi -morbidity guidance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee think about when thinking about reviewing and co-ordinating care?. ### Response: including aspects of the multi -morbidity guidance.


Instruction: Who highlighted an important sub -population of HF patients?

Output: The committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who highlighted an important sub -population of HF patients?. ### Response: The committee.


Instruction: What is an important sub-population of HF patients?

Output: housebound

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an important sub-population of HF patients?. ### Response: housebound.


Instruction: Housebound patients are often not reviewed by what?

Output: HF clinics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Housebound patients are often not reviewed by what?. ### Response: HF clinics.


Instruction: What is not seen in GP surgery?

Output: HF patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not seen in GP surgery?. ### Response: HF patients.


Instruction: What did the committee feel some people in these circumstances received care only once they were acutely unwell?

Output: recommendations regarding six -monthly review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee feel some people in these circumstances received care only once they were acutely unwell?. ### Response: recommendations regarding six -monthly review.


Instruction: What should patients be included in the recommendations regarding six -monthly review?

Output: housebound. It was recognised that they are often not reviewed by HF clinics, and not seen in the GP surgery, and therefore perhaps not routinely seen by t he primary healthcare team either. It was felt that some people in these circumstances only received care once they were acutely unwell

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients be included in the recommendations regarding six -monthly review?. ### Response: housebound. It was recognised that they are often not reviewed by HF clinics, and not seen in the GP surgery, and therefore perhaps not routinely seen by t he primary healthcare team either. It was felt that some people in these circumstances only received care once they were acutely unwell.


Instruction: What were reviews for housebound patients with HF sometimes delegated to?

Output: district nurses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were reviews for housebound patients with HF sometimes delegated to?. ### Response: district nurses.


Instruction: What did the committee feel should be done by someone with competencies in?

Output: clinical examination and medicines optimi sation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee feel should be done by someone with competencies in?. ### Response: clinical examination and medicines optimi sation.


Instruction: In the TRITON-TIMI 38 trial, what was the inci-dence of CABG-related major bleeding in patients treated with prasugrel?

Output: higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the TRITON-TIMI 38 trial, what was the inci-dence of CABG-related major bleeding in patients treated with prasugrel?. ### Response: higher.


Instruction: In the PLATO trial, the rates of major bleeding and transfusion requirements were similar between which two trials?

Output: patients treated with ticagrelor and patients treated with clopidogrel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the PLATO trial, the rates of major bleeding and transfusion requirements were similar between which two trials?. ### Response: patients treated with ticagrelor and patients treated with clopidogrel.


Instruction: What were the rates of major bleeding and transfusion requirements similar between patients treated with ticagrelor and clopidogrel?

Output: In the PLATO trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the rates of major bleeding and transfusion requirements similar between patients treated with ticagrelor and clopidogrel?. ### Response: In the PLATO trial.


Instruction: What was the more rapid recovery of platelet function?

Output: pharmacokinetic Table 9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the more rapid recovery of platelet function?. ### Response: pharmacokinetic Table 9.


Instruction: How many therapeutic SC doses of enoxaparin have been administered?

Output: <2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many therapeutic SC doses of enoxaparin have been administered?. ### Response: <2.


Instruction: What should be given to patients who have not received prior anticoagulant therapy?

Output: Enoxaparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be given to patients who have not received prior anticoagulant therapy?. ### Response: Enoxaparin.


Instruction: What is the IV dose of enoxaparin?

Output: 0.3 mg/kg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the IV dose of enoxaparin?. ### Response: 0.3 mg/kg.


Instruction: What should be given if the last SC dose was administered within prior 8 h?

Output: no additional enoxaparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be given if the last SC dose was administered within prior 8 h?. ### Response: no additional enoxaparin.


Instruction: For patients who have received UFH, wait 30 min, then give 0.75 mg of what?

Output: /kg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For patients who have received UFH, wait 30 min, then give 0.75 mg of what?. ### Response: /kg.


Instruction: What do patients who have received UFH wait 30 min for?

Output: IV loading dose, then 1.75 mg/kg/h IV infusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do patients who have received UFH wait 30 min for?. ### Response: IV loading dose, then 1.75 mg/kg/h IV infusion.


Instruction: What is the IV loading dose for patients who are already receiving bivalirudin infusion?

Output: 0.5 mg/

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the IV loading dose for patients who are already receiving bivalirudin infusion?. ### Response: 0.5 mg/.


Instruction: How long does it take to give 0.75 mg/kg loading dose?

Output: 30 min

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take to give 0.75 mg/kg loading dose?. ### Response: 30 min.


Instruction: Dosage of fondaparinux should be 0.5 mg/kg and increase infusion to what?

Output: 1.75 mg/kg/h IV infusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Dosage of fondaparinux should be 0.5 mg/kg and increase infusion to what?. ### Response: 1.75 mg/kg/h IV infusion.


Instruction: Do you need to administer additional IV treatment with anticoagulant possessing anti-IIa activity?

Output: For prior treatment with fondaparinux

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Do you need to administer additional IV treatment with anticoagulant possessing anti-IIa activity?. ### Response: For prior treatment with fondaparinux.


Instruction: How many U of UFH are needed to administer IV GPI?

Output: 2000–5000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many U of UFH are needed to administer IV GPI?. ### Response: 2000–5000.


Instruction: How much UFH is needed to achieve ACT of 200-250 s?

Output: 2000–5000 U

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much UFH is needed to achieve ACT of 200-250 s?. ### Response: 2000–5000 U.


Instruction: How many U/kg loading dose is needed for IV GPI?

Output: 50–70

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many U/kg loading dose is needed for IV GPI?. ### Response: 50–70.


Instruction: What is the target ACT for HemoTec?

Output: 250–300 s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the target ACT for HemoTec?. ### Response: 250–300 s.


Instruction: How many U/kg loading dose is planned?

Output: 70–100

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many U/kg loading dose is planned?. ### Response: 70–100.


Instruction: What are the drugs presented in order of?

Output: the COR and then the LOE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the drugs presented in order of?. ### Response: the COR and then the LOE.


Instruction: How many drugs exist within the same LOE?

Output: more than 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many drugs exist within the same LOE?. ### Response: more than 1.


Instruction: What indicates activated clotting time?

Output: ACT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates activated clotting time?. ### Response: ACT.


Instruction: How are drugs listed when there is no comparative data?

Output: alphabetically

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are drugs listed when there is no comparative data?. ### Response: alphabetically.


Instruction: What is GPI?

Output: glycoprotein IIb/IIIa inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is GPI?. ### Response: glycoprotein IIb/IIIa inhibitor.


Instruction: What is IV?

Output: intravenous

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is IV?. ### Response: intravenous.


Instruction: Where is LOE located?

Output: Level of Evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is LOE located?. ### Response: Level of Evidence.


Instruction: How is PCI performed?

Output: percutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is PCI performed?. ### Response: percutaneous coronary intervention.


Instruction: What is a Key Question Specif ic Criteria?

Output: Literature Search Strategy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a Key Question Specif ic Criteria?. ### Response: Literature Search Strategy.


Instruction: What is the Literature Search Strategy?

Output: Key Question Specif ic Criteria  .................................................................................................... 74 c. Literature Search Strategy  ......................................................................................................... 75 C. Convening the Face -to-face Meeting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Literature Search Strategy?. ### Response: Key Question Specif ic Criteria  .................................................................................................... 74 c. Literature Search Strategy  ......................................................................................................... 75 C. Convening the Face -to-face Meeting.


Instruction: How are Recommendations categorized?

Output: Categories and Definitions  .......................................................................... 79 b. Categorizing Recommendations with an Updated Review of the Evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are Recommendations categorized?. ### Response: Categories and Definitions  .......................................................................... 79 b. Categorizing Recommendations with an Updated Review of the Evidence.


Instruction: What is an Appendix B: Patient Focus Group Methods and Procedures?

Output: 81 Appendix B:  Patient Focus Group Methods and Findings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an Appendix B: Patient Focus Group Methods and Procedures?. ### Response: 81 Appendix B:  Patient Focus Group Methods and Findings.


Instruction: What is a Definition?

Output: Recommendation Categories and Definitions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a Definition?. ### Response: Recommendation Categories and Definitions.


Instruction: What is the name of the Appendix B: Patient Focus Group Methods and Findings?

Output: 83

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Appendix B: Patient Focus Group Methods and Findings?. ### Response: 83.


Instruction: What is one of the ways to provide comprehensive info rmation and education to patients regarding their condition?

Output: expanding available information on complementary and alternative therapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the ways to provide comprehensive info rmation and education to patients regarding their condition?. ### Response: expanding available information on complementary and alternative therapies.


Instruction: Self-management, including expanding available information on what?

Output: complementary and alternative therapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Self-management, including expanding available information on what?. ### Response: complementary and alternative therapies.


Instruction: Improve the method of measuring what in the office?

Output: blood pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Improve the method of measuring what in the office?. ### Response: blood pressure.


Instruction: What are the most commonly prescribed agents for hyperlipidemia?

Output: Statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the most commonly prescribed agents for hyperlipidemia?. ### Response: Statins.


Instruction: What have statins been shown to improve?

Output: survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have statins been shown to improve?. ### Response: survival.


Instruction: What has been shown to improve survival and reduce the risks of adverse car -diovascular events across a wide range of cholesterol levels?

Output: Statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been shown to improve survival and reduce the risks of adverse car -diovascular events across a wide range of cholesterol levels?. ### Response: Statins.


Instruction: Statins also reduce the progression of native artery atheroscle-rosis.

Output: 77,80–82

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Statins also reduce the progression of native artery atheroscle-rosis.. ### Response: 77,80–82.


Instruction: What have statins been demonstrated to inhibit the development of?

Output: saphe-nous vein graft disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have statins been demonstrated to inhibit the development of?. ### Response: saphe-nous vein graft disease.


Instruction: What has been shown to inhibit the development of saphenous vein graft disease?

Output: statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been shown to inhibit the development of saphenous vein graft disease?. ### Response: statins.


Instruction: What have statins reduced by reducing neointimal formation and smooth muscle proliferation?

Output: saphe-nous vein graft disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have statins reduced by reducing neointimal formation and smooth muscle proliferation?. ### Response: saphe-nous vein graft disease.


Instruction: How many patients had previously undergone CABG 1?

Output: 1351

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had previously undergone CABG 1?. ### Response: 1351.


Instruction: How many patients underwent CABG 1 to 11 years earlier?

Output: 1351

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients underwent CABG 1 to 11 years earlier?. ### Response: 1351.


Instruction: What were the patients randomized to after the CABG Trial?

Output: aggres-sive cholesterol reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the patients randomized to after the CABG Trial?. ### Response: aggres-sive cholesterol reduction.


Instruction: How much lovastatin did the patients receive?

Output: 40 to 80 mg daily

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much lovastatin did the patients receive?. ### Response: 40 to 80 mg daily.


Instruction: What is the daily dose of lovastatin?

Output: 2.5 to 5 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the daily dose of lovastatin?. ### Response: 2.5 to 5 mg.


Instruction: What was the mean LDL level of patients who received aggressive treatment?

Output: 93 to 97 mg/dL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean LDL level of patients who received aggressive treatment?. ### Response: 93 to 97 mg/dL.


Instruction: How long after study initiation did angiography demonstrate the reduction in LDL levels?

Output: ≈4 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after study initiation did angiography demonstrate the reduction in LDL levels?. ### Response: ≈4 years.


Instruction: How long after study initiation did angiography show that aggressive cholesterol reduction lowered the incidence of new vein graft occlusions?

Output: ≈4 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after study initiation did angiography show that aggressive cholesterol reduction lowered the incidence of new vein graft occlusions?. ### Response: ≈4 years.


Instruction: How much did aggressive reduction versus moderate reduction reduce the number of veins grafted with progression of atherosclerosis?

Output: 27% versus 39%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much did aggressive reduction versus moderate reduction reduce the number of veins grafted with progression of atherosclerosis?. ### Response: 27% versus 39%,.


Instruction: What was the difference between aggressive reduction and moderate reduction?

Output: 39%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the difference between aggressive reduction and moderate reduction?. ### Response: 39%,.


Instruction: How much reduction in the need for repeat revascularization was associated with the aggressive treatment approach?

Output: 30%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much reduction in the need for repeat revascularization was associated with the aggressive treatment approach?. ### Response: 30%.


Instruction: What did the post-CABG trial show in terms of adverse cardiovascular events?

Output: reduced both cardiovascular events and the progression of atherosclerosis in native coronary arter -ies and saphenous vein grafts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the post-CABG trial show in terms of adverse cardiovascular events?. ### Response: reduced both cardiovascular events and the progression of atherosclerosis in native coronary arter -ies and saphenous vein grafts.


Instruction: What did the Post-CABG trial show reduced both cardiovascular events and the progression of atherosclerosis in native coronary arteries and saphenous vein grafts?

Output: aggressive lowering of LDL to <100 mg/dL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Post-CABG trial show reduced both cardiovascular events and the progression of atherosclerosis in native coronary arteries and saphenous vein grafts?. ### Response: aggressive lowering of LDL to <100 mg/dL.


Instruction: What has been confirmed in several other randomized trials?

Output: The importance of postoperative LDL reduction with statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been confirmed in several other randomized trials?. ### Response: The importance of postoperative LDL reduction with statins.


Instruction: What has been confirmed in several other randomized and observational studies in the cardiac surgery literature?

Output: The importance of postoperative LDL reduction with statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been confirmed in several other randomized and observational studies in the cardiac surgery literature?. ### Response: The importance of postoperative LDL reduction with statins.


Instruction: What did a small, controlled trial published in 1999?

Output: statin treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a small, controlled trial published in 1999?. ### Response: statin treatment.


Instruction: How long did statin treatment continue for after CABG reduced the risk of MI?

Output: 1 year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did statin treatment continue for after CABG reduced the risk of MI?. ### Response: 1 year.


Instruction: What was reduced in the perioperative period?

Output: risk of MI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was reduced in the perioperative period?. ### Response: risk of MI.


Instruction: What was the risk of MI during the first year after CABG?

Output: 0% ver -sus 19%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk of MI during the first year after CABG?. ### Response: 0% ver -sus 19%,.


Instruction: How many patients received statin treatment within 1 month of CABG in a cohort study?

Output: 7503

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients received statin treatment within 1 month of CABG in a cohort study?. ### Response: 7503.


Instruction: How many patients had statin treatment within 1 month of CABG?

Output: 7503

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had statin treatment within 1 month of CABG?. ### Response: 7503.


Instruction: What is one of the research priorities identified by the panel?

Output: developing validated specific DOAC effect tests

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the research priorities identified by the panel?. ### Response: developing validated specific DOAC effect tests.


Instruction: What can be performed quickly and ideally at the point of care?

Output: developing validated specific DOAC effect tests

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be performed quickly and ideally at the point of care?. ### Response: developing validated specific DOAC effect tests.


Instruction: What should LMWH or UFH be used for patients transitioning from DOAC to VKA?

Output: bridging therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should LMWH or UFH be used for patients transitioning from DOAC to VKA?. ### Response: bridging therapy.


Instruction: What should patients use until the INR is within the therapeutic range?

Output: overlapping DOAC therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients use until the INR is within the therapeutic range?. ### Response: overlapping DOAC therapy.


Instruction: What does the ASHguideline panel suggest for patients transitioning from DOAC to VKA?

Output: overlapping DOAC and VKA therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the ASHguideline panel suggest for patients transitioning from DOAC to VKA?. ### Response: overlapping DOAC and VKA therapy.


Instruction: What is the conditional recommendation based on?

Output: very low certainty in the evidence about effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the conditional recommendation based on?. ### Response: very low certainty in the evidence about effects.


Instruction: How many studies did we find that included patients with atrialfibrillation, not VTE, transitioning from DOAC therapy to VKA therapy?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies did we find that included patients with atrialfibrillation, not VTE, transitioning from DOAC therapy to VKA therapy?. ### Response: 3.


Instruction: What did three studies report about mortality outcomes?

Output: only in the group overlapping DOAC during the transitionto VKA114-116

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did three studies report about mortality outcomes?. ### Response: only in the group overlapping DOAC during the transitionto VKA114-116.


Instruction: How many studies reported mortality outcomes during the transition to VKA114-116?

Output: Three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies reported mortality outcomes during the transition to VKA114-116?. ### Response: Three.


Instruction: 1 study reported development of what type of stroke115?

Output: hemorrhagic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: 1 study reported development of what type of stroke115?. ### Response: hemorrhagic.


Instruction: No studies reported outcomes related to what?

Output: quality-of-life impairment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No studies reported outcomes related to what?. ### Response: quality-of-life impairment.


Instruction: TheEtD framework is shown online at https://dbep.gradepro.org/profile/b1889d83-5875-453f-b047-fb742c25e43e What is the evidence profile in the EtD Framework?

Output: Benefits. For benefits

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: TheEtD framework is shown online at https://dbep.gradepro.org/profile/b1889d83-5875-453f-b047-fb742c25e43e What is the evidence profile in the EtD Framework?. ### Response: Benefits. For benefits.


Instruction: What is the benefit of LMWH-bridging therapy?

Output: increase the risk for VTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the benefit of LMWH-bridging therapy?. ### Response: increase the risk for VTE.


Instruction: What was not available for the 30-day follow-up period?

Output: deaths

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not available for the 30-day follow-up period?. ### Response: deaths.


Instruction: How long was the follow-up period for VTE?

Output: 30-day

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the follow-up period for VTE?. ### Response: 30-day.


Instruction: What was the RR of LMWH-bridging therapy during the transition from DOAC to VKA compared with overlapping DOAC therapy?

Output: 5.58

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the RR of LMWH-bridging therapy during the transition from DOAC to VKA compared with overlapping DOAC therapy?. ### Response: 5.58.


Instruction: What was the RR of overlapping DOAC therapy?

Output: 5.58

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the RR of overlapping DOAC therapy?. ### Response: 5.58.


Instruction: How many more events per 1000 were there per 1000?

Output: 20

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many more events per 1000 were there per 1000?. ### Response: 20.


Instruction: What was implemented only when the patient was at highthromboembolic risk?

Output: LMWH-bridging strategy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was implemented only when the patient was at highthromboembolic risk?. ### Response: LMWH-bridging strategy.


Instruction: What was associated with a lowermajor bleeding risk?

Output: The interv ention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with a lowermajor bleeding risk?. ### Response: The interv ention.


Instruction: Why was there no reliable RRand 95% CI?

Output: very few bleeding eventswere observed and none occurred in the LMWH-bridging group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was there no reliable RRand 95% CI?. ### Response: very few bleeding eventswere observed and none occurred in the LMWH-bridging group.