Instruction: What is the effect of clus-tering to resolve heterogeneity?

Output: unsupervised

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of clus-tering to resolve heterogeneity?. ### Response: unsupervised.


Instruction: When was the BMC Med published?

Output: November 14, 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the BMC Med published?. ### Response: November 14, 2007.


Instruction: What is saline used for?

Output: prevention of radiocontrast-inducednephropathy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is saline used for?. ### Response: prevention of radiocontrast-inducednephropathy.


Instruction: How many regimens are used to protect contrast-induced nephropathy in patients undergoing coronary procedures?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many regimens are used to protect contrast-induced nephropathy in patients undergoing coronary procedures?. ### Response: 3.


Instruction: What is the asingle-center prospective controlled trial?

Output: LIPSIA-N-ACC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the asingle-center prospective controlled trial?. ### Response: LIPSIA-N-ACC.


Instruction: What did the LIPSIA-N-ACC trial focus on?

Output: contrast-induced nephropathy andmyocardial reperfusion injury

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the LIPSIA-N-ACC trial focus on?. ### Response: contrast-induced nephropathy andmyocardial reperfusion injury.


Instruction: What is the name of the randomized controlled trial of intravenous N-acetylcysteine?

Output: LIPSIA-N-ACC (Prospective, Single-Blind,Placebo-Controlled, Randomized Leipzig Immediate PercutaneouSCoronary Intervention Acute Myocardial Infarction N-ACC) trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized controlled trial of intravenous N-acetylcysteine?. ### Response: LIPSIA-N-ACC (Prospective, Single-Blind,Placebo-Controlled, Randomized Leipzig Immediate PercutaneouSCoronary Intervention Acute Myocardial Infarction N-ACC) trial.


Instruction: What is N-acetylcysteine used for?

Output: prevention of radiocontrast-inducednephropathy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is N-acetylcysteine used for?. ### Response: prevention of radiocontrast-inducednephropathy.


Instruction: What is the lack of effect of the randomized controlled trial?

Output: lack of effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the lack of effect of the randomized controlled trial?. ### Response: lack of effect.


Instruction: When did ACT Investigators publish their findings?

Output: November 14, 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did ACT Investigators publish their findings?. ### Response: November 14, 2007.


Instruction: What is the cost of eplerenone in addition to standa rd therapy for heart failure with reduced ejection fraction?

Output: £3,520

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cost of eplerenone in addition to standa rd therapy for heart failure with reduced ejection fraction?. ### Response: £3,520.


Instruction: What was assessed as partially applicable with potentially serious limitations?

Output: spironolactone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was assessed as partially applicable with potentially serious limitations?. ### Response: spironolactone.


Instruction: One cost -effectiveness anal ysis found that spironolactone is more costly and more effective than optimal medical management alone?

Output: One cost -effectiveness anal ysis found that spironolactone in addition to optimal medical management is more costly and more effective than optimal medical management alone. This was assessed as partially applicable with potentially serious limitations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: One cost -effectiveness anal ysis found that spironolactone is more costly and more effective than optimal medical management alone?. ### Response: One cost -effectiveness anal ysis found that spironolactone in addition to optimal medical management is more costly and more effective than optimal medical management alone. This was assessed as partially applicable with potentially serious limitations.


Instruction: What is a mineralcorticoid receptor antagonist?

Output: MRA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a mineralcorticoid receptor antagonist?. ### Response: MRA.


Instruction: What is an angiotensin converting enzyme inhibitor?

Output: ACE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an angiotensin converting enzyme inhibitor?. ### Response: ACE.


Instruction: What is beta -blocker given to people with heart failure with reduced ejection fraction if they continue to have symptoms of heart failure?

Output: angiotensin -converting enzyme (ACE) inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is beta -blocker given to people with heart failure with reduced ejection fraction if they continue to have symptoms of heart failure?. ### Response: angiotensin -converting enzyme (ACE) inhibitor.


Instruction: What is the name of the multi-ethnic study of atherosclerosis?

Output: MESA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multi-ethnic study of atherosclerosis?. ### Response: MESA.


Instruction: What is the title of the 2017 ACC/AHA/HFSA Heart Failure Focused UpdateCirculation. 2017;136:e137–e161.

Output: 10.1161/CIR.0000000000000509

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of the 2017 ACC/AHA/HFSA Heart Failure Focused UpdateCirculation. 2017;136:e137–e161.. ### Response: 10.1161/CIR.0000000000000509.


Instruction: Who is the professor of medicine at Brigham and Women's Hospital?

Output: Michael M. Givertz

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the professor of medicine at Brigham and Women's Hospital?. ### Response: Michael M. Givertz.


Instruction: What hospital is the director of the Coronary Care Unit, Professor of Medicine?

Output: Cooper University Hospital

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What hospital is the director of the Coronary Care Unit, Professor of Medicine?. ### Response: Cooper University Hospital.


Instruction: Who is the Director of the Coronary Care Unit at Vanderbilt Heart and Vascular Institute?

Output: JoAnn Lindenfeld

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Director of the Coronary Care Unit at Vanderbilt Heart and Vascular Institute?. ### Response: JoAnn Lindenfeld.


Instruction: What is the name of the section of the Institute that specializes in advanced heart failure and transplantation?

Output: Vanderbilt Heart and Vascular Institute

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the section of the Institute that specializes in advanced heart failure and transplantation?. ### Response: Vanderbilt Heart and Vascular Institute.


Instruction: Which company is the director of the Advanced Heart Failure and Transplant Section?

Output: Vanderbilt Heart and Vascular Institute

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which company is the director of the Advanced Heart Failure and Transplant Section?. ### Response: Vanderbilt Heart and Vascular Institute.


Instruction: What is the name of the professor of medicine at the Anschutz Medical Campus?

Output: Frederick A. Masoudi

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor of medicine at the Anschutz Medical Campus?. ### Response: Frederick A. Masoudi.


Instruction: Who is the associate director of preventive cardiology at the University of Wisconsin School of Medicine and Public Health?

Output: Patrick E. McBride

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the associate director of preventive cardiology at the University of Wisconsin School of Medicine and Public Health?. ### Response: Patrick E. McBride.


Instruction: Who is the Associate Director of Preventive Cardiology at the University of Colorado, Denver Health Medical Center?

Output: Patrick E. McBride

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Associate Director of Preventive Cardiology at the University of Colorado, Denver Health Medical Center?. ### Response: Patrick E. McBride.


Instruction: What is the title of the Associate Professor of Medicine, Division of Cardiology?

Output: Pamela N. Peterson

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of the Associate Professor of Medicine, Division of Cardiology?. ### Response: Pamela N. Peterson.


Instruction: Who is the Director of the Cardiomyopathy and Heart Failure Program at Azusa Pacific University?

Output: Lynne Warner Stevenson

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Director of the Cardiomyopathy and Heart Failure Program at Azusa Pacific University?. ### Response: Lynne Warner Stevenson.


Instruction: What is the name of the Novartis-PARENT trial?

Output: PI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Novartis-PARENT trial?. ### Response: PI.


Instruction: Who was the Co-PI of the NHLBI?

Output: None None

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the Co-PI of the NHLBI?. ### Response: None None.


Instruction: How were committee members' relationships with industry and other entities determined to be relevant to this document?

Output: This table

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How were committee members' relationships with industry and other entities determined to be relevant to this document?. ### Response: This table.


Instruction: What was reviewed and updated in conjunction with all meetings and conference calls of the writing committee during the document development process?

Output: relationships of committee members with industry and other entities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was reviewed and updated in conjunction with all meetings and conference calls of the writing committee during the document development process?. ### Response: relationships of committee members with industry and other entities.


Instruction: What does not necessarily reflect relationships with industry at the time of publication?

Output: The table

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not necessarily reflect relationships with industry at the time of publication?. ### Response: The table.


Instruction: What is deemed to have a significant interest in a business if the interest represents ownership of 5% of the voting stock or share of the business entity?

Output: A person

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is deemed to have a significant interest in a business if the interest represents ownership of 5% of the voting stock or share of the business entity?. ### Response: A person.


Instruction: How much of the fair market does a person own?

Output: $5000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the fair market does a person own?. ### Response: $5000.


Instruction: How much of the fair market value of the business entity does the person own?

Output: $5000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the fair market value of the business entity does the person own?. ### Response: $5000.


Instruction: What percentage of the person's gross income do the funds received by the person from a business entity exceed for the previous year?

Output: 5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the person's gross income do the funds received by the person from a business entity exceed for the previous year?. ### Response: 5%.


Instruction: Relationships that exist with no financial benefit are included for the purpose of what?

Output: transparency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Relationships that exist with no financial benefit are included for the purpose of what?. ### Response: transparency.


Instruction: What are relationships in this table modest unless otherwise noted?

Output: Relationships that exist with no financial benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are relationships in this table modest unless otherwise noted?. ### Response: Relationships that exist with no financial benefit.


Instruction: According to the ACC/AHA, a person has a relevant relationship if: a) The relationship or interest relates to the same or similar subject matter, intellectual property, or what else?

Output: 136:e137–e161

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: According to the ACC/AHA, a person has a relevant relationship if: a) The relationship or interest relates to the same or similar subject matter, intellectual property, or what else?. ### Response: 136:e137–e161.


Instruction: What is the name of the book that treats heart failure chronic heart failure?

Output: NICE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the book that treats heart failure chronic heart failure?. ### Response: NICE.


Instruction: Who is the author of NICE 2018?

Output: 978 -1-4731 -3093 -7 190

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of NICE 2018?. ### Response: 978 -1-4731 -3093 -7 190.


Instruction: What is the CI for the relative effect of ARB?

Output: 95%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the CI for the relative effect of ARB?. ### Response: 95%.


Instruction: What is a risk with placebo risk difference with ARB 95% CI?

Output: Anticipated absolute effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk with placebo risk difference with ARB 95% CI?. ### Response: Anticipated absolute effects.


Instruction: How many events were there in both arms?

Output: zero

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many events were there in both arms?. ### Response: zero.


Instruction: Table 63: ARB high dose versus low dose (CKD class 3a/b) Outcomes

Output: No of Participants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Table 63: ARB high dose versus low dose (CKD class 3a/b) Outcomes. ### Response: No of Participants.


Instruction: What is CKD class 3a/b?

Output: ARB high dose versus low dose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CKD class 3a/b?. ### Response: ARB high dose versus low dose.


Instruction: What is Quality of the evidence?

Output: Relative effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Quality of the evidence?. ### Response: Relative effect.


Instruction: Anticipated absolute effects Risk with low dose Risk difference with ARB high dose 95% CI?

Output: Placebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Anticipated absolute effects Risk with low dose Risk difference with ARB high dose 95% CI?. ### Response: Placebo.


Instruction: What is the risk difference with ARB high dose (95% CI)?

Output: Risk with low dose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk difference with ARB high dose (95% CI)?. ### Response: Risk with low dose.


Instruction: How many studies were conducted?

Output: 945

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were conducted?. ### Response: 945.


Instruction: What was the combined outcome of the study?

Output: death or HF hospitalisation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the combined outcome of the study?. ### Response: death or HF hospitalisation.


Instruction: Why was the risk of bias, indirectness LOW?

Output: due to risk of bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the risk of bias, indirectness LOW?. ### Response: due to risk of bias.


Instruction: How many fewer per 1000 were there?

Output: 6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many fewer per 1000 were there?. ### Response: 6.


Instruction: How many increments were there if the majority of the evidence was at high risk of bias?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many increments were there if the majority of the evidence was at high risk of bias?. ### Response: 2.


Instruction: How many increments were given if the majority of the evidence was at very high risk of bias?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many increments were given if the majority of the evidence was at very high risk of bias?. ### Response: 2.


Instruction: Why was the 1 increment downgraded due to indirectness?

Output: outcome was compound rather than numbers of admissions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the 1 increment downgraded due to indirectness?. ### Response: outcome was compound rather than numbers of admissions.


Instruction: What was the outcome compound rather than numbers of admissions?

Output: death or HF hospitalisation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome compound rather than numbers of admissions?. ### Response: death or HF hospitalisation.


Instruction: What is the term for CKD stages 3-4?

Output: Beta -blocker versus placebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for CKD stages 3-4?. ### Response: Beta -blocker versus placebo.


Instruction: What is another term for Quality of the evidence?

Output: GRADE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for Quality of the evidence?. ### Response: GRADE.


Instruction: What is the 95% CI of all-cause mortality - CKD class 3a 1645?

Output: Risk difference with Beta -blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 95% CI of all-cause mortality - CKD class 3a 1645?. ### Response: Risk difference with Beta -blocker.


Instruction: Why is LOWb due to risk of bias?

Output: indirectness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is LOWb due to risk of bias?. ### Response: indirectness.


Instruction: How many fewer per 1000 is estimated?

Output: 6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many fewer per 1000 is estimated?. ### Response: 6.


Instruction: How many fewer people die from CKD?

Output: 30

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many fewer people die from CKD?. ### Response: 30.


Instruction: How many more deaths are there per 1000?

Output: 820

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many more deaths are there per 1000?. ### Response: 820.


Instruction: What is the all-cause mortality rate?

Output: HR 0.5 5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the all-cause mortality rate?. ### Response: HR 0.5 5.


Instruction: What was seen in all the BMI ranges?

Output: Improvement in QOL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was seen in all the BMI ranges?. ### Response: Improvement in QOL.


Instruction: What did the data from HF-ACTION suggest?

Output: physical activity as part of an exercise program is safe in obese patients with HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the data from HF-ACTION suggest?. ### Response: physical activity as part of an exercise program is safe in obese patients with HF.


Instruction: What do the data from HF-ACTION suggest is safe in obese patients with HF and may improve QOL?

Output: physical activity as part of an exercise program

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do the data from HF-ACTION suggest is safe in obese patients with HF and may improve QOL?. ### Response: physical activity as part of an exercise program.


Instruction: What does the section on the metabolic syndrome give further information on?

Output: exercise as part of lifestyle modification

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the section on the metabolic syndrome give further information on?. ### Response: exercise as part of lifestyle modification.


Instruction: How many weight-loss medications are approved for the long-term treatment of overweight and obesity in the US general population?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many weight-loss medications are approved for the long-term treatment of overweight and obesity in the US general population?. ### Response: 3.


Instruction: Orlistat, lorcaserin, and orlistat are examples of what?

Output: MedicationsCurrently, only 3 weight-loss medications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Orlistat, lorcaserin, and orlistat are examples of what?. ### Response: MedicationsCurrently, only 3 weight-loss medications.


Instruction: What is orlistat a lipase inhibitor?

Output: obese patients with HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is orlistat a lipase inhibitor?. ### Response: obese patients with HF.


Instruction: How many obese patients with HF were randomized to orlistate?

Output: Twenty-one

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many obese patients with HF were randomized to orlistate?. ### Response: Twenty-one.


Instruction: What drug was recently approved in the US?

Output: lorcaserin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug was recently approved in the US?. ### Response: lorcaserin.


Instruction: How much weight loss did the orlistat group have compared to the control group?

Output: (−4.65±9.8 kg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much weight loss did the orlistat group have compared to the control group?. ### Response: (−4.65±9.8 kg.


Instruction: What was the difference in LVEF between the two groups?

Output: <40%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the difference in LVEF between the two groups?. ### Response: <40%.


Instruction: What group had more improvement in 6-minute walk distance and in NYHA class compared with the control group?

Output: orlistat

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What group had more improvement in 6-minute walk distance and in NYHA class compared with the control group?. ### Response: orlistat.


Instruction: What is lorcaserin an agonist of the 5-hydroxytrypta-mine receptor 2C?

Output: The safety of lorcaserin, an agonist of the 5-hydroxytrypta-mine (serotonin) receptor 2C, in patients with HF is un-known

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is lorcaserin an agonist of the 5-hydroxytrypta-mine receptor 2C?. ### Response: The safety of lorcaserin, an agonist of the 5-hydroxytrypta-mine (serotonin) receptor 2C, in patients with HF is un-known.


Instruction: What is phentermine and topiramate used for?

Output: adults with a BMI >30 kg/m2 and at least 1 weight-related condition

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is phentermine and topiramate used for?. ### Response: adults with a BMI >30 kg/m2 and at least 1 weight-related condition.


Instruction: What is the BMI of the combination of phéntermine & topiramate?

Output: >30 kg/m2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the BMI of the combination of phéntermine & topiramate?. ### Response: >30 kg/m2.


Instruction: How many weight-related conditions are present in adults with a BMI >30 kg/m2?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many weight-related conditions are present in adults with a BMI >30 kg/m2?. ### Response: 1.


Instruction: How many weight-related conditions are there?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many weight-related conditions are there?. ### Response: 1.


Instruction: What does the US Food and Drug Administration say the drug can increase?

Output: heart rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the US Food and Drug Administration say the drug can increase?. ### Response: heart rate.


Instruction: Who is required to perform a long-term post-marketing study of cardiovascu-lar outcomes associated with Ephedra?

Output: the sponsor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is required to perform a long-term post-marketing study of cardiovascu-lar outcomes associated with Ephedra?. ### Response: the sponsor.


Instruction: What has been used for the purposes of athletic performance enhancement and weight loss?

Output: Ephedra

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been used for the purposes of athletic performance enhancement and weight loss?. ### Response: Ephedra.


Instruction: What has been linked to a high rate of serious adverse outcomes?

Output: Ephedra

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been linked to a high rate of serious adverse outcomes?. ### Response: Ephedra.


Instruction: What was the ban of sibutra-mine by the US Food and Drug Administration?

Output: Ephedra

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the ban of sibutra-mine by the US Food and Drug Administration?. ### Response: Ephedra.


Instruction: What is the name of the drug that has been used in HF?

Output: Orlistat

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug that has been used in HF?. ### Response: Orlistat.


Instruction: What type of disease has been reported in patients with HF238?

Output: cardiomyopathy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of disease has been reported in patients with HF238?. ### Response: cardiomyopathy.


Instruction: Why is sibutra-mine contraindicated?

Output: reports of the development of cardiomyopathy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is sibutra-mine contraindicated?. ### Response: reports of the development of cardiomyopathy.


Instruction: What was the primary end point of cardiovascular death or HF hospitalization reduced by?

Output: 37%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary end point of cardiovascular death or HF hospitalization reduced by?. ### Response: 37%.


Instruction: The EMPHASIS trial supported the benefits of eplerenone in chronic HF with mild symptoms (NYHA class II) with what type of symptoms?

Output: mild

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The EMPHASIS trial supported the benefits of eplerenone in chronic HF with mild symptoms (NYHA class II) with what type of symptoms?. ### Response: mild.


Instruction: What did the trials not specifically evaluate?

Output: patients with hypertension and HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the trials not specifically evaluate?. ### Response: patients with hypertension and HF.


Instruction: The improvement in relative risk with eplerenone was greater in the subgroup with a history of what?

Output: hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The improvement in relative risk with eplerenone was greater in the subgroup with a history of what?. ### Response: hypertension.


Instruction: What may be particularly beneficial in patients with hypertension and HF?

Output: lower BPs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be particularly beneficial in patients with hypertension and HF?. ### Response: lower BPs.


Instruction: What should be monitored to prevent hyperkalemia?

Output: Electrolytes and renal function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be monitored to prevent hyperkalemia?. ### Response: Electrolytes and renal function.


Instruction: Radiofrequency ablation of renal sympathetic nerves has recently gained attention for its ability to what?

Output: reduce BP in those with resistant hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Radiofrequency ablation of renal sympathetic nerves has recently gained attention for its ability to what?. ### Response: reduce BP in those with resistant hypertension.


Instruction: What has recently gained attention for its ability to reduce BP in those with resistant hypertension?

Output: radiofrequency ablation of renal sympathetic nerves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has recently gained attention for its ability to reduce BP in those with resistant hypertension?. ### Response: radiofrequency ablation of renal sympathetic nerves.


Instruction: A small study has demonstrated the ability of what to induce LV hypertrophy regression and to improve LV systolic function?

Output: carvedilol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A small study has demonstrated the ability of what to induce LV hypertrophy regression and to improve LV systolic function?. ### Response: carvedilol.


Instruction: In the first large-scale clinical trial of renal denervation in patents, what was the first?

Output: COPERNICUS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the first large-scale clinical trial of renal denervation in patents, what was the first?. ### Response: COPERNICUS.


Instruction: What was the name of the first large-scale clinical trial of renal denervation in patents with resistant hyper -tension?

Output: Renal Denervation in Patients With Uncontrolled Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the first large-scale clinical trial of renal denervation in patents with resistant hyper -tension?. ### Response: Renal Denervation in Patients With Uncontrolled Hypertension.


Instruction: What was a sham procedure called?

Output: Renal Denervation in Patients With Uncontrolled Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a sham procedure called?. ### Response: Renal Denervation in Patients With Uncontrolled Hypertension.


Instruction: How did the 2 groups reduce SBP?

Output: 110 to 130 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did the 2 groups reduce SBP?. ### Response: 110 to 130 mm Hg.


Instruction: What is the future of renal denervation in the management of hypertension uncertain?

Output: there was no sig-nificant difference between the 2 groups in the reduction of SBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the future of renal denervation in the management of hypertension uncertain?. ### Response: there was no sig-nificant difference between the 2 groups in the reduction of SBP.


Instruction: What is needed to clarify its role in this patient population?

Output: future ran-domized trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed to clarify its role in this patient population?. ### Response: future ran-domized trials.


Instruction: Who should lower both SBP and SBP?

Output: Healthcare providers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should lower both SBP and SBP?. ### Response: Healthcare providers.


Instruction: What should health care providers do in accordance with the recommendations provided in pub-lished guidelines?

Output: lower both SBP and DBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should health care providers do in accordance with the recommendations provided in pub-lished guidelines?. ### Response: lower both SBP and DBP.


Instruction: What is the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure?

Output: lower both SBP and DBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure?. ### Response: lower both SBP and DBP.


Instruction: What has not been firmly established in HF?

Output: BP targets

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has not been firmly established in HF?. ### Response: BP targets.


Instruction: In most successful tri-als, SBP was lowered to what range?

Output: 110 to 130 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In most successful tri-als, SBP was lowered to what range?. ### Response: 110 to 130 mm Hg.


Instruction: What trial demonstrated benefits of carvedilol in patients with entry criteria that included SBPs down to 85 mm Hg?

Output: COPERNICUS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What trial demonstrated benefits of carvedilol in patients with entry criteria that included SBPs down to 85 mm Hg?. ### Response: COPERNICUS.


Instruction: What should the target BP in patients with HF be?

Output: <140/90 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should the target BP in patients with HF be?. ### Response: <140/90 mm Hg.


Instruction: What is the mean pretreatment BP?

Output: 123/76 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the mean pretreatment BP?. ### Response: 123/76 mm Hg.


Instruction: What should target BP in patients with HF be?

Output: <140/90 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should target BP in patients with HF be?. ### Response: <140/90 mm Hg.


Instruction: What should be checked for orthostatic changes with standing?

Output: Octogenarians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be checked for orthostatic changes with standing?. ### Response: Octogenarians.


Instruction: What should be avoided?

Output: Drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be avoided?. ### Response: Drugs.


Instruction: What should an SBP 130 mm Hg be avoided with?

Output: Drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should an SBP 130 mm Hg be avoided with?. ### Response: Drugs.


Instruction: What does the WorkGroup believe not all patients and providers will value?

Output: theinformation provided by ABPM and HBPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the WorkGroup believe not all patients and providers will value?. ### Response: theinformation provided by ABPM and HBPM.


Instruction: Prior studies have found that a majority of patients prefer HBPM to what?

Output: ABPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Prior studies have found that a majority of patients prefer HBPM to what?. ### Response: ABPM.


Instruction: What do most patients prefer to HBPM?

Output: ABPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do most patients prefer to HBPM?. ### Response: ABPM.


Instruction: What has been reported by patients to result in fewer disturbances in their daily activities?

Output: BP measurements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been reported by patients to result in fewer disturbances in their daily activities?. ### Response: BP measurements.


Instruction: What is ABPM cost-saving and cost-effective for the management of high BP in the general population?

Output: Resource use and costs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ABPM cost-saving and cost-effective for the management of high BP in the general population?. ### Response: Resource use and costs.


Instruction: What type of studies were not conducted in CKD?

Output: observational studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of studies were not conducted in CKD?. ### Response: observational studies.


Instruction: What is the cost-effectiveness of HBPM for management of high BP?

Output: unclear

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cost-effectiveness of HBPM for management of high BP?. ### Response: unclear.


Instruction: What may be less inclined to follow this recommendation?

Output: Persons with limited ﬁnancial resources

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be less inclined to follow this recommendation?. ### Response: Persons with limited ﬁnancial resources.


Instruction: The use of ABPM orHBPM will depend on the resources available.

Output: lack ofdevice availability

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The use of ABPM orHBPM will depend on the resources available.. ### Response: lack ofdevice availability.


Instruction: Staff should be trained to conduct what?

Output: ABPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Staff should be trained to conduct what?. ### Response: ABPM.


Instruction: What does ABPM require every 1 - 2 years?

Output: recalibration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ABPM require every 1 - 2 years?. ### Response: recalibration.


Instruction: There are no standardizedprotocols for calibrating what?

Output: HBPM devices

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There are no standardizedprotocols for calibrating what?. ### Response: HBPM devices.


Instruction: What should providers ask patients to bring their HBPM device to the office to compare?

Output: BP values

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should providers ask patients to bring their HBPM device to the office to compare?. ### Response: BP values.


Instruction: What does this recommendation place a high value on informing anindividual’s overall BP pro file and identifying persons withhigh CV disease risks related to highBP?

Output: 42Rationale

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does this recommendation place a high value on informing anindividual’s overall BP pro file and identifying persons withhigh CV disease risks related to highBP?. ### Response: 42Rationale.


Instruction: What does high BP recommenda-tion place a lower value on?

Output: potential lack ofdevice availability, cost, and patient burden

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does high BP recommenda-tion place a lower value on?. ### Response: potential lack ofdevice availability, cost, and patient burden.


Instruction: What does observational studies indicate about highBP?

Output: the diagnosis of highBP and BP control status differs for a high proportion ofadults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does observational studies indicate about highBP?. ### Response: the diagnosis of highBP and BP control status differs for a high proportion ofadults.


Instruction: What do observational studies indicate a stronger associ-ation of out-of-fice BP measurements with CV and kidneyoutcomes?

Output: diagnosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do observational studies indicate a stronger associ-ation of out-of-fice BP measurements with CV and kidneyoutcomes?. ### Response: diagnosis.


Instruction: What is a potential treatment for masked uncontrolledhypertension?

Output: Antihy-pertensive medication

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a potential treatment for masked uncontrolledhypertension?. ### Response: Antihy-pertensive medication.


Instruction: What has potential treatment implications?

Output: Identi ﬁcation of “white-coat ”hypertension, masked hy-pertension, the “white-coat ”effect, and masked uncontrolledhypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has potential treatment implications?. ### Response: Identi ﬁcation of “white-coat ”hypertension, masked hy-pertension, the “white-coat ”effect, and masked uncontrolledhypertension.


Instruction: What can be considered for patients with substantial masked uncontrolled hypertension?

Output: Antihy-pertensive medication initiation and intensi ﬁcation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be considered for patients with substantial masked uncontrolled hypertension?. ### Response: Antihy-pertensive medication initiation and intensi ﬁcation.


Instruction: How can antihy-pertensive medication initiation and intensi fication be considered?

Output: patients with substantial masked hypertensionand masked uncontrolled hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can antihy-pertensive medication initiation and intensi fication be considered?. ### Response: patients with substantial masked hypertensionand masked uncontrolled hypertension.


Instruction: What is the age range of aortic valve replacement in patients?

Output: 50 to 70 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the age range of aortic valve replacement in patients?. ### Response: 50 to 70 years.


Instruction: What is improved outcome with mechanical versus biologic prostheses?

Output: Aortic valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is improved outcome with mechanical versus biologic prostheses?. ### Response: Aortic valve replacement.


Instruction: What is the difference between mechanical and bioprosthetic valve replacement in middle-aged patients?

Output: improved outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between mechanical and bioprosthetic valve replacement in middle-aged patients?. ### Response: improved outcome.


Instruction: What is weighed against lifetime anticoagulant-related event risk?

Output: reopera-tion risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is weighed against lifetime anticoagulant-related event risk?. ### Response: reopera-tion risk.


Instruction: What year did Eur J Cardiothorac Surg.30:485–91?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Eur J Cardiothorac Surg.30:485–91?. ### Response: 2006.


Instruction: How old are patients with aortic valve replacements?

Output: 50 to 70 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old are patients with aortic valve replacements?. ### Response: 50 to 70 years.


Instruction: Where can a copy of this study be found?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can a copy of this study be found?. ### Response: http://ahajournals.org.


Instruction: How much of the usual dose of enoxaparin is given to CrCl patients?

Output: 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the usual dose of enoxaparin is given to CrCl patients?. ### Response: 50%.


Instruction: What is the usual dosage of LMWH?

Output: 1 mg/kg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the usual dosage of LMWH?. ### Response: 1 mg/kg.


Instruction: When given in prophylactic doses, what is the effect on the cardiovascular system?

Output: LMWH has not been shown to increase the risk of bleeding complica-tions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When given in prophylactic doses, what is the effect on the cardiovascular system?. ### Response: LMWH has not been shown to increase the risk of bleeding complica-tions.


Instruction: What has not been shown to increase the risk of bleeding complica-tions?

Output: drug accumulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has not been shown to increase the risk of bleeding complica-tions?. ### Response: drug accumulation.


Instruction: What was found in patients with renal failure who received repeated once-daily prophylactic doses of enoxaparin?

Output: higher anti-Xa levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was found in patients with renal failure who received repeated once-daily prophylactic doses of enoxaparin?. ### Response: higher anti-Xa levels.


Instruction: What was the mean peak anti-Xa level?

Output: 0.6 units/mL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean peak anti-Xa level?. ### Response: 0.6 units/mL.


Instruction: How many units/mL was the trough?

Output: 0.2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many units/mL was the trough?. ### Response: 0.2.


Instruction: What was no increased bleeding observed?

Output: aparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was no increased bleeding observed?. ### Response: aparin.


Instruction: What was not observed in a study of critically ill patients with a wide range of renal function?

Output: dalteparin bioaccu-mulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not observed in a study of critically ill patients with a wide range of renal function?. ### Response: dalteparin bioaccu-mulation.


Instruction: What was given daily to consec-utive ICU patients?

Output: subcutaneous dalteparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was given daily to consec-utive ICU patients?. ### Response: subcutaneous dalteparin.


Instruction: How many International Units was dalteparin given to?

Output: 5,000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many International Units was dalteparin given to?. ### Response: 5,000.


Instruction: How many International Units were given daily to consec-utive ICU patients?

Output: 5,000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many International Units were given daily to consec-utive ICU patients?. ### Response: 5,000.


Instruction: How much creatinine clearance did the patients have?

Output: 30 mL/min

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much creatinine clearance did the patients have?. ### Response: 30 mL/min.


Instruction: What was the risk of bleeding increased?

Output: no evidence of drug accumulation nor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk of bleeding increased?. ### Response: no evidence of drug accumulation nor.


Instruction: What is the recommended dose of enoxaparin for CrCl patients?

Output: 30 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommended dose of enoxaparin for CrCl patients?. ### Response: 30 mg.


Instruction: How many units of tinzaparin were used once daily in a small comparative study?

Output: 4,500

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many units of tinzaparin were used once daily in a small comparative study?. ### Response: 4,500.


Instruction: How long did it take for enoxaparin to bioaccumulate?

Output: 8 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for enoxaparin to bioaccumulate?. ### Response: 8 days.


Instruction: What was seen in 8 days of exposure?

Output: bioaccumulation of enoxaparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was seen in 8 days of exposure?. ### Response: bioaccumulation of enoxaparin.


Instruction: For other LMWHs, dosing recommendations cannot be made in the setting of what?

Output: renal insufﬁ  ciency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For other LMWHs, dosing recommendations cannot be made in the setting of what?. ### Response: renal insufﬁ  ciency.


Instruction: What is there no proven method for neutralizing LMWH?

Output: protamine sulfate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is there no proven method for neutralizing LMWH?. ### Response: protamine sulfate.


Instruction: Studies in vitro and in animals have demon-strated that protamine sulfate neutralizes the anti-IIa activity of what?

Output: LMWH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Studies in vitro and in animals have demon-strated that protamine sulfate neutralizes the anti-IIa activity of what?. ### Response: LMWH.


Instruction: What neutralizes a variable portion of the anti-Xa activity of LMWH?

Output: protamine sulfate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What neutralizes a variable portion of the anti-Xa activity of LMWH?. ### Response: protamine sulfate.


Instruction: Protamine does not bind to what?

Output: LMWH fragments

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Protamine does not bind to what?. ### Response: LMWH fragments.


Instruction: What does sulfate neutralize?

Output: anti-IIa activity of LMWH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does sulfate neutralize?. ### Response: anti-IIa activity of LMWH.


Instruction: What are LMWH preparations that have low sulfate charge density?

Output: LMWH fragments

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are LMWH preparations that have low sulfate charge density?. ### Response: LMWH fragments.


Instruction: What is the clinical signifi cce of incomplete anti-Xa neutralization?

Output: unclear

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the clinical signifi cce of incomplete anti-Xa neutralization?. ### Response: unclear.


Instruction: How many patients have clinical bleeding associated with LMWH?

Output: three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients have clinical bleeding associated with LMWH?. ### Response: three.


Instruction: How many of the 169 patients have bleeding associated?

Output: three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many of the 169 patients have bleeding associated?. ### Response: three.


Instruction: What is there no human studies that demonstrate or refute a benefi cial effect of protamine sulfate on?

Output: © 2012 American College of Chest Physicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is there no human studies that demonstrate or refute a benefi cial effect of protamine sulfate on?. ### Response: © 2012 American College of Chest Physicians.


Instruction: What is the name of the book written by Kimberly Henricks?

Output: American College of Chest Physicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the book written by Kimberly Henricks?. ### Response: American College of Chest Physicians.


Instruction: When was chestjournal.chestpubs.org released?

Output: February 10, 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was chestjournal.chestpubs.org released?. ### Response: February 10, 2012.


Instruction: Who is a Content Reviewer at the University of Pennsylvania?

Output: Howard C. Herrmann

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a Content Reviewer at the University of Pennsylvania?. ### Response: Howard C. Herrmann.


Instruction: Who is the Director ofInterventional CardiologyProgram at the Perelman School ofMedicine?

Output: Professor ofMedicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Director ofInterventional CardiologyProgram at the Perelman School ofMedicine?. ### Response: Professor ofMedicine.


Instruction: Who is a Content Reviewer at Mayo Clinic?

Output: Fred M. Kosumoto

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a Content Reviewer at Mayo Clinic?. ### Response: Fred M. Kosumoto.


Instruction: What is the name of the professor at Stanford University School ofMedicine?

Output: David J. Maron

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor at Stanford University School ofMedicine?. ### Response: David J. Maron.


Instruction: Who is a professor of medicine at the University of Arizona?

Output: Douglass A. Morrison

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a professor of medicine at the University of Arizona?. ### Response: Douglass A. Morrison.


Instruction: What is the name of the content reviewer at Arizona State University?

Output: Douglass A. Morrison

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the content reviewer at Arizona State University?. ### Response: Douglass A. Morrison.


Instruction: Who is an Associate Professor of Medicine at the Duke University MedicalCenter?

Output: Manesh R. Patel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is an Associate Professor of Medicine at the Duke University MedicalCenter?. ### Response: Manesh R. Patel.


Instruction: What is the name of the professor of medicine at the University Hospitals CaseMedical Center?

Output: Associate Professorof Medicine/C15Bayer Healthcare */C15JanssenPharmaceuticals *None None /C15Johnson & Johnson * None NoneM. Eugene Sherman Content Reviewer —ACCBoard of GovernorsAurora Denver Cardiology None None None None /C15Bristol-MyersSquibb */C15Hospira *NoneDaniel I. Simon

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor of medicine at the University Hospitals CaseMedical Center?. ### Response: Associate Professorof Medicine/C15Bayer Healthcare */C15JanssenPharmaceuticals *None None /C15Johnson & Johnson * None NoneM. Eugene Sherman Content Reviewer —ACCBoard of GovernorsAurora Denver Cardiology None None None None /C15Bristol-MyersSquibb */C15Hospira *NoneDaniel I. Simon.


Instruction: What is the name of the Content Reviewer at Summit Medical Group?

Output: William A. Tansey III

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Content Reviewer at Summit Medical Group?. ### Response: William A. Tansey III.


Instruction: Who is the Chief, Division of Cardiology at San Francisco GeneralHospital?

Output: David D. Waters

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Chief, Division of Cardiology at San Francisco GeneralHospital?. ### Response: David D. Waters.


Instruction: What is the title of the Chief of Cardiology Division at the San Francisco GeneralHospital?

Output: Chief

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of the Chief of Cardiology Division at the San Francisco GeneralHospital?. ### Response: Chief.


Instruction: What does ACC/AHA/SCAI focus on in 2015?

Output: Primary PCI1249

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ACC/AHA/SCAI focus on in 2015?. ### Response: Primary PCI1249.


Instruction: What is KDIGO?

Output: Kidney Disease: Improving Global Outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is KDIGO?. ### Response: Kidney Disease: Improving Global Outcomes.


Instruction: What is CKD?

Output: chronic kidney disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CKD?. ### Response: chronic kidney disease.


Instruction: How is eGFR calculated?

Output: estimated glomerular ﬁltration rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is eGFR calculated?. ### Response: estimated glomerular ﬁltration rate.


Instruction: GFR is what?

Output: glomerular ﬁltration rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: GFR is what?. ### Response: glomerular ﬁltration rate.


Instruction: What is Improving Global Outcomes?

Output: Kidney Disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Improving Global Outcomes?. ### Response: Kidney Disease.


Instruction: What is a randomized controlled trial?

Output: RCT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a randomized controlled trial?. ### Response: RCT.


Instruction: What is the high risk of cerebral-vein thrombosis in carriers of a prothrombin-gene mutation and in users of oral contraceptives?

Output: 203. Martinelli I

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the high risk of cerebral-vein thrombosis in carriers of a prothrombin-gene mutation and in users of oral contraceptives?. ### Response: 203. Martinelli I.


Instruction: What was the N Engl J Med. 1998;338:1793–1797?

Output: High risk of cerebral-vein thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the N Engl J Med. 1998;338:1793–1797?. ### Response: High risk of cerebral-vein thrombosis.


Instruction: What type of thrombosis is associated with pregnancy?

Output: Cerebral venous

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of thrombosis is associated with pregnancy?. ### Response: Cerebral venous.


Instruction: What is the name of the 2012 issue of Thromb Res?

Output: 130(suppl 1):S19–S22

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2012 issue of Thromb Res?. ### Response: 130(suppl 1):S19–S22.


Instruction: Who is the author of "Developing and clinical appli-cations of novel oral anticoagulants, part I: clinical approved drugs?"

Output: Ahrens I, Peter K, Lip GY , Bode C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of "Developing and clinical appli-cations of novel oral anticoagulants, part I: clinical approved drugs?". ### Response: Ahrens I, Peter K, Lip GY , Bode C.


Instruction: What type of thrombophilia is tested in patients with first venous thrombus?

Output: Selective

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of thrombophilia is tested in patients with first venous thrombus?. ### Response: Selective.


Instruction: How many relatives participated in a retrospective family cohort study?

Output: 2479

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many relatives participated in a retrospective family cohort study?. ### Response: 2479.


Instruction: How many relatives were at risk for currently known thrombophilic defects?

Output: 2479

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many relatives were at risk for currently known thrombophilic defects?. ### Response: 2479.


Instruction: Blood. 2009;113:5314–5322.

Output: 207

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Blood. 2009;113:5314–5322.. ### Response: 207.


Instruction: What was Coutinho's response to?

Output: letter by Coutinho et al regarding article, “Mortality of cerebral venous-sinus thrombosis in a large national sample

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was Coutinho's response to?. ### Response: letter by Coutinho et al regarding article, “Mortality of cerebral venous-sinus thrombosis in a large national sample.


Instruction: Stroke. 2012;43:e23.

Output: 262–264

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Stroke. 2012;43:e23.. ### Response: 262–264.


Instruction: What is the name of the thrombosis in a large national sample?

Output: cerebral venous-sinus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the thrombosis in a large national sample?. ### Response: cerebral venous-sinus.


Instruction: How many people died from cerebral venous-sinus thrombus in 2012?

Output: 209

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people died from cerebral venous-sinus thrombus in 2012?. ### Response: 209.


Instruction: What was the cause of death in the study?

Output: Peripartum stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the cause of death in the study?. ### Response: Peripartum stroke.


Instruction: What is the Mortality in cerebral venous thrombosis: results from the National Inpatient Sample database?

Output: 209

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Mortality in cerebral venous thrombosis: results from the National Inpatient Sample database?. ### Response: 209.


Instruction: What is Lanska DJ, Kryscio RJ?

Output: National Hospital Discharge Survey

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Lanska DJ, Kryscio RJ?. ### Response: National Hospital Discharge Survey.


Instruction: What is the name of the 2008 edition of the American College of Chest Physicians Evidence-Based Clinical Practice Guidelines?

Output: 8th

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2008 edition of the American College of Chest Physicians Evidence-Based Clinical Practice Guidelines?. ### Response: 8th.


Instruction: What is the 8th edition of the Guidelines?

Output: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 8th edition of the Guidelines?. ### Response: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.


Instruction: What was the title of the 2008 edition?

Output: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the title of the 2008 edition?. ### Response: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.


Instruction: How did Ciron J, Godenèche G, Vandamme X, Rosier MP, Sharov I, Mathis S, Larrieu D, Neau JP, Cerebrovasc Dis. 2013:36:55–61?

Output: Obstetrical outcome of young women with a past history of cerebral venous thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Ciron J, Godenèche G, Vandamme X, Rosier MP, Sharov I, Mathis S, Larrieu D, Neau JP, Cerebrovasc Dis. 2013:36:55–61?. ### Response: Obstetrical outcome of young women with a past history of cerebral venous thrombosis.


Instruction: What was the period of use of contraception in the United States from 1982 to 2008?

Output: 1982–2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the period of use of contraception in the United States from 1982 to 2008?. ### Response: 1982–2008.


Instruction: What did Vital Health Stat 23. 2010:(29):1–44?

Output: Use of contraception

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Vital Health Stat 23. 2010:(29):1–44?. ### Response: Use of contraception.


Instruction: Gillum LA, Mamidipudi SK, Johnston SC. Ischemic stroke risk with oral contraceptives: a meta-analysis. JAMA. 2000;284:72–78.

Output: 216

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Gillum LA, Mamidipudi SK, Johnston SC. Ischemic stroke risk with oral contraceptives: a meta-analysis. JAMA. 2000;284:72–78.. ### Response: 216.


Instruction: What is a risk of stroke in women exposed to low-dose oral contraceptives?

Output: Ischemic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk of stroke in women exposed to low-dose oral contraceptives?. ### Response: Ischemic.


Instruction: What is an association between the current use of oral contraception and stroke risk?

Output: cardiovascular arterial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an association between the current use of oral contraception and stroke risk?. ### Response: cardiovascular arterial.


Instruction: What is the association between the current use of low-dose oral contraceptives and cardiovascular arterial disease?

Output: High risk of cerebral-vein thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association between the current use of low-dose oral contraceptives and cardiovascular arterial disease?. ### Response: High risk of cerebral-vein thrombosis.


Instruction: What does DK, Essah PA, Nestler JE do?

Output: Association between the current use of low-dose oral contraceptives

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does DK, Essah PA, Nestler JE do?. ### Response: Association between the current use of low-dose oral contraceptives.


Instruction: What was of border-line statistical significance between treatment effect and PCI?

Output: P/H110050.026

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was of border-line statistical significance between treatment effect and PCI?. ### Response: P/H110050.026.


Instruction: What is the current recommended loading dose for clopidogrel uncertain?

Output: dosing table

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the current recommended loading dose for clopidogrel uncertain?. ### Response: dosing table.


Instruction: How many hours are required to metabolize the active metabolite?

Output: several hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many hours are required to metabolize the active metabolite?. ### Response: several hours.


Instruction: Why is there a window of time where there is a reduced level of effectiveness even after several hours?

Output: metabolize clopidogrelto its active metabolite

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is there a window of time where there is a reduced level of effectiveness even after several hours?. ### Response: metabolize clopidogrelto its active metabolite.


Instruction: What does PPI stand for?

Output: Proton pump inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does PPI stand for?. ### Response: Proton pump inhibitor.


Instruction: What are PPIs used for when clopidogrel is started?

Output: to prevent gastrointestinal (GI) complica-tions such as ulceration and related bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are PPIs used for when clopidogrel is started?. ### Response: to prevent gastrointestinal (GI) complica-tions such as ulceration and related bleeding.


Instruction: What are PPIs prescribed to prevent?

Output: gastrointestinal (GI) complica-tions such as ulceration and related bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are PPIs prescribed to prevent?. ### Response: gastrointestinal (GI) complica-tions such as ulceration and related bleeding.


Instruction: What is a common cause of GI complica-tions such as ulceration and related bleeding34?

Output: dualantiplatelet therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a common cause of GI complica-tions such as ulceration and related bleeding34?. ### Response: dualantiplatelet therapy.


Instruction: Along with aspirin and clopidogrel, what is another dual antiplatelet therapy?

Output: Proton Pump Inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Along with aspirin and clopidogrel, what is another dual antiplatelet therapy?. ### Response: Proton Pump Inhibitors.


Instruction: Inpatients who have received a DES have been put more emphasis on what?

Output: prevention of prematurediscontinuation of dual antiplatelet therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Inpatients who have received a DES have been put more emphasis on what?. ### Response: prevention of prematurediscontinuation of dual antiplatelet therapy.


Instruction: What type of therapy is recommended for inpatients who have received a DES for whom 12 months ofantiplatelet therapy are recommended?

Output: dual antiplatelet therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is recommended for inpatients who have received a DES for whom 12 months ofantiplatelet therapy are recommended?. ### Response: dual antiplatelet therapy.


Instruction: What has been retrospective reports of when the antiplatelet regimen of clopidogrel and aspirin is accompa-nied by PPIs assessed as a group compared with use of thisregimen?

Output: adverse cardio-vascular outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been retrospective reports of when the antiplatelet regimen of clopidogrel and aspirin is accompa-nied by PPIs assessed as a group compared with use of thisregimen?. ### Response: adverse cardio-vascular outcomes.


Instruction: What was assessed as a group compared with use of thisregimen without a PPI?

Output: PPIs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was assessed as a group compared with use of thisregimen without a PPI?. ### Response: PPIs.


Instruction: In a retrospective cohort study what did Neid et al 2012 UA/NSTEMI Focused Update 883 download from http://ahajournals.org by on April 28, 2023?

Output: Jneid et al 2012 UA/NSTEMI Focused Update 883Downloaded from http://ahajournals.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In a retrospective cohort study what did Neid et al 2012 UA/NSTEMI Focused Update 883 download from http://ahajournals.org by on April 28, 2023?. ### Response: Jneid et al 2012 UA/NSTEMI Focused Update 883Downloaded from http://ahajournals..


Instruction: What did Whelton and colleagues 2017 High Blood Pressure Clinical Practice Guideline e27masked hypertension and masked uncontrolled hypertension have an increased prevalence of?

Output: target organ damage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Whelton and colleagues 2017 High Blood Pressure Clinical Practice Guideline e27masked hypertension and masked uncontrolled hypertension have an increased prevalence of?. ### Response: target organ damage.


Instruction: What is the risk of target organ damage and CVD, stroke and mortality associated with?

Output: increased prevalence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of target organ damage and CVD, stroke and mortality associated with?. ### Response: increased prevalence.


Instruction: What is an algorithm on the detection of white coat hypertension or masked hypertension in patients not on drug therapy?

Output: Figure 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an algorithm on the detection of white coat hypertension or masked hypertension in patients not on drug therapy?. ### Response: Figure 1.


Instruction: What is a summary of Table 12?

Output: BP patterns based on office and out-of-office measurements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a summary of Table 12?. ### Response: BP patterns based on office and out-of-office measurements.


Instruction: What is a summary of BP patterns based on office and out-of-office measurements?

Output: Table 12

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a summary of BP patterns based on office and out-of-office measurements?. ### Response: Table 12.


Instruction: White coat hypertension prevalence averages approximately what percentage?

Output: 13%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: White coat hypertension prevalence averages approximately what percentage?. ### Response: 13%.


Instruction: What are better predictors of CVD risk due to elevated BP than of-fice BP measurements?

Output: S4.4-1,S4.4-2 and ABPM and HBPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are better predictors of CVD risk due to elevated BP than of-fice BP measurements?. ### Response: S4.4-1,S4.4-2 and ABPM and HBPM.


Instruction: Which is the preferred measurement option?

Output: ABPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which is the preferred measurement option?. ### Response: ABPM.


Instruction: What is the major clinical relevance of white coat hypertension?

Output: it has typically been as-sociated with a minimal to only slightly increased risk of CVD and all-cause mortality risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the major clinical relevance of white coat hypertension?. ### Response: it has typically been as-sociated with a minimal to only slightly increased risk of CVD and all-cause mortality risk.


Instruction: What is the overlap with ABPM for detection of white coat hypertension?

Output: 60% to 70%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the overlap with ABPM for detection of white coat hypertension?. ### Response: 60% to 70%.


Instruction: What percentage for detection of white coat hypertension?

Output: 60% to 70%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage for detection of white coat hypertension?. ### Response: 60% to 70%.


Instruction: What is the incidence of whitecoat hypertension converting to sustained hypertension justifying the addition of antihy-pertentive drug therapy to lifestyle modification?

Output: 1% to 5% per year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the incidence of whitecoat hypertension converting to sustained hypertension justifying the addition of antihy-pertentive drug therapy to lifestyle modification?. ### Response: 1% to 5% per year.


Instruction: What is the overlap between HBPM and both daytime and 24-hour ABPM in diagnosing white coat hypertension?

Output: 60% to 70%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the overlap between HBPM and both daytime and 24-hour ABPM in diagnosing white coat hypertension?. ### Response: 60% to 70%.


Instruction: The data for prediction of CVD risk are stronger with what?

Output: ABPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The data for prediction of CVD risk are stronger with what?. ### Response: ABPM.


Instruction: What is stronger with ABPM than with office measurements?

Output: the data for prediction of CVD risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is stronger with ABPM than with office measurements?. ### Response: the data for prediction of CVD risk.


Instruction: Why may a diagnosis of white coat hypertension result in a decision not to treat or intensify treatment in patients with elevated office BP readings?

Output: confirmation of BP control by ABPM in ad-dition to HBPM provides added support for this decision

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why may a diagnosis of white coat hypertension result in a decision not to treat or intensify treatment in patients with elevated office BP readings?. ### Response: confirmation of BP control by ABPM in ad-dition to HBPM provides added support for this decision.


Instruction: What provides additional support for this decision?

Output: confirmation of BP control by ABPM in ad-dition to HBPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What provides additional support for this decision?. ### Response: confirmation of BP control by ABPM in ad-dition to HBPM.


Instruction: What is masked hypertension associated with a CVD and all-cause mortality risk twice as high as?

Output: that seen in normotensive individuals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is masked hypertension associated with a CVD and all-cause mortality risk twice as high as?. ### Response: that seen in normotensive individuals.


Instruction: What is a risk range similar to that of patients with sustained hypertension?

Output: S4.4-3,S4.4-4,S4.4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk range similar to that of patients with sustained hypertension?. ### Response: S4.4-3,S4.4-4,S4.4.


Instruction: Out-of-office readings are reasonable to confirm BP control seen with what?

Output: office readings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Out-of-office readings are reasonable to confirm BP control seen with what?. ### Response: office readings.


Instruction: What has been implicated in office-measured uncontrolled hypertension and pseudo-resistant hypertension?

Output: The white coat effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been implicated in office-measured uncontrolled hypertension and pseudo-resistant hypertension?. ### Response: The white coat effect.


Instruction: The white coat effect may result in what being underestimated when subsequently?

Output: BP control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The white coat effect may result in what being underestimated when subsequently?. ### Response: BP control.


Instruction: What may result in BP control being underestimated when subsequently assessed by ABPM?

Output: The white coat effect has been implicated in office-measured uncontrolled hypertension and pseudo-  resistant hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may result in BP control being underestimated when subsequently assessed by ABPM?. ### Response: The white coat effect has been implicated in office-measured uncontrolled hypertension and pseudo-  resistant hypertension.


Instruction: What is the risk of vascular complications?

Output: increased prevalence of target organ damage and risk of CVD, stroke, and mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of vascular complications?. ### Response: increased prevalence of target organ damage and risk of CVD, stroke, and mortality.


Instruction: What is the title of this book?

Output: Chronic Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of this book?. ### Response: Chronic Heart Failure.


Instruction: What are the methods used to review the evidence and to develop the recommendations that are presented in subsequent chapters?

Output: Chronic Heart Failure  Methods  © NICE 2018. All rights reserved. Subject to Notice of rights. ISBN: 978 -1-4731 -3093 -7 34 4 Methods

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the methods used to review the evidence and to develop the recommendations that are presented in subsequent chapters?. ### Response: Chronic Heart Failure  Methods  © NICE 2018. All rights reserved. Subject to Notice of rights. ISBN: 978 -1-4731 -3093 -7 34 4 Methods.


Instruction: How was this guideline developed?

Output: in accordance with the methods outlined in the NICE guidelin es manual

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was this guideline developed?. ### Response: in accordance with the methods outlined in the NICE guidelin es manual.


Instruction: What was the 2014 version of the NICE guideline?

Output: .236

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 2014 version of the NICE guideline?. ### Response: .236.


Instruction: Which sections describe the process used to identify and review clinical evidence?

Output: 4.1 to 4.3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which sections describe the process used to identify and review clinical evidence?. ### Response: 4.1 to 4.3.


Instruction: What describes the process used to identify and review clinical evidence?

Output: Sections 4.1 to 4.3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What describes the process used to identify and review clinical evidence?. ### Response: Sections 4.1 to 4.3.


Instruction: What sections describe the process of identifying and reviewing the health economic evidence? What section describes the processes used to develop recommendations?

Output: section 4.5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What sections describe the process of identifying and reviewing the health economic evidence? What section describes the processes used to develop recommendations?. ### Response: section 4.5.


Instruction: What framework was used to develop the review questions and outcomes?

Output: PICO

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What framework was used to develop the review questions and outcomes?. ### Response: PICO.


Instruction: What framework were used for intervention reviews?

Output: PICO

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What framework were used for intervention reviews?. ### Response: PICO.


Instruction: How were review questions developed?

Output: using a PICO framework ( population , intervention, comparison and outcome) fo r intervention reviews

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How were review questions developed?. ### Response: using a PICO framework ( population , intervention, comparison and outcome) fo r intervention reviews.


Instruction: What is used for reviews of diagnostic test accuracy?

Output: a framework of population, index tests, reference standard and target condition

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used for reviews of diagnostic test accuracy?. ### Response: a framework of population, index tests, reference standard and target condition.


Instruction: What are some examples of factors under investigation?

Output: prognostic factors) and  outcomes for prognostic reviews

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some examples of factors under investigation?. ### Response: prognostic factors) and  outcomes for prognostic reviews.


Instruction: Who drafted the review questions?

Output: NGC  technical team

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who drafted the review questions?. ### Response: NGC  technical team.


Instruction: What did the framework of population, setting and context guide?

Output: qualitative reviews

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the framework of population, setting and context guide?. ### Response: qualitative reviews.


Instruction: How many review questions were identified?

Output: 26

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many review questions were identified?. ### Response: 26.


Instruction: What is a term for a study or analysis of the cost of using and distributing healthcare resources?

Output: Health economics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a term for a study or analysis of the cost of using and distributing healthcare resources?. ### Response: Health economics.