Instruction: Why are the direct thrombin inhibitor dabigatran or the factor Xa inhibitors rivaroxaban or edoxaban not recommended?

Output: lack of evidence from clinical trials that benefit exceeds risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why are the direct thrombin inhibitor dabigatran or the factor Xa inhibitors rivaroxaban or edoxaban not recommended?. ### Response: lack of evidence from clinical trials that benefit exceeds risk.


Instruction: What is the name of the direct thrombin inhibitor that should not be used?

Output: dabigatran

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the direct thrombin inhibitor that should not be used?. ### Response: dabigatran.


Instruction: What drug received FDA approval and has been added to the recommendation?

Output: Edoxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug received FDA approval and has been added to the recommendation?. ### Response: Edoxaban.


Instruction: What is the name of the direct thrombin inhibitor that should not be used in patients with AF and a mechanical heart valve?

Output: dabigatran

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the direct thrombin inhibitor that should not be used in patients with AF and a mechanical heart valve?. ### Response: dabigatran.


Instruction: What was updated from B to B-R?

Output: LOE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was updated from B to B-R?. ### Response: LOE.


Instruction: What is the name of the 2014 AF Guideline?

Output: Section 4.1. in the 2014 AF Guideline)III: Harm B-R17

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2014 AF Guideline?. ### Response: Section 4.1. in the 2014 AF Guideline)III: Harm B-R17.


Instruction: How many mg of edoxaban were used in a large ran-domized prospective AF trial?

Output: 30 or 60

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mg of edoxaban were used in a large ran-domized prospective AF trial?. ### Response: 30 or 60.


Instruction: What was found to be noninferior to warfarin?

Output: Edoxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was found to be noninferior to warfarin?. ### Response: Edoxaban.


Instruction: Warfarin was associated with significantly lower rates of bleed-ing and death from what?

Output: cardiovascular causes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Warfarin was associated with significantly lower rates of bleed-ing and death from what?. ### Response: cardiovascular causes.


Instruction: What should be based on assessment of the risks of stroke and bleeding?

Output: Treatment of patients with AF with edoxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be based on assessment of the risks of stroke and bleeding?. ### Response: Treatment of patients with AF with edoxaban.


Instruction: What is ENGAGE-TIMI 48 based on?

Output: Effective Anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ENGAGE-TIMI 48 based on?. ### Response: Effective Anticoagulation.


Instruction: What are the risks of stroke and bleeding?

Output: Treatment of patients with AF with edoxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the risks of stroke and bleeding?. ### Response: Treatment of patients with AF with edoxaban.


Instruction: What is the functional outcome of hemorrhagic stroke patients after in-patient rehabilitation?

Output: daily activities and motor function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the functional outcome of hemorrhagic stroke patients after in-patient rehabilitation?. ### Response: daily activities and motor function.


Instruction: What was the Am J Phys Med Rehabil. 1996;75:177–182?

Output: Functional outcome of hemorrhagic and nonhemorrhagic stroke patients after in-patient rehabilitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the Am J Phys Med Rehabil. 1996;75:177–182?. ### Response: Functional outcome of hemorrhagic and nonhemorrhagic stroke patients after in-patient rehabilitation.


Instruction: Kelly PJ, Furie KL, Shafqat S, Rallis N, Chang Y, Stein J. Functional recovery following rehabilitation after what?

Output: hemorrhagic and ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Kelly PJ, Furie KL, Shafqat S, Rallis N, Chang Y, Stein J. Functional recovery following rehabilitation after what?. ### Response: hemorrhagic and ischemic stroke.


Instruction: What does functional recovery differ between ischaemic and haemorrhagic stroke patients?

Output: daily activities and motor function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does functional recovery differ between ischaemic and haemorrhagic stroke patients?. ### Response: daily activities and motor function.


Instruction: What is the name of the journal that studies functional recovery after stroke?

Output: J Rehabil Med.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies functional recovery after stroke?. ### Response: J Rehabil Med..


Instruction: How many stroke patients have functional recovery?

Output: 325

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many stroke patients have functional recovery?. ### Response: 325.


Instruction: How many stroke patients have a better functional outcome than patients with cerebral infarction?

Output: 317. Katrak PH, Black D, Peeva V . Do stroke patients with intracerebral hemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many stroke patients have a better functional outcome than patients with cerebral infarction?. ### Response: 317. Katrak PH, Black D, Peeva V . Do stroke patients with intracerebral hemorrhage.


Instruction: What is a review of diffusion tensor imaging studies in stroke patients?

Output: Jang SH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a review of diffusion tensor imaging studies in stroke patients?. ### Response: Jang SH.


Instruction: What are imaging studies on in stroke patients?

Output: motor recovery mechanisms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are imaging studies on in stroke patients?. ### Response: motor recovery mechanisms.


Instruction: What are outpatient service trialists doing?

Output: Therapy-based rehabilitation services for stroke patients at home

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are outpatient service trialists doing?. ### Response: Therapy-based rehabilitation services for stroke patients at home.


Instruction: What is the name of the Cochrane Database Syst Rev. 2003?

Output: 1):CD002925

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Cochrane Database Syst Rev. 2003?. ### Response: 1):CD002925.


Instruction: What is a review of compara-tive evidence and experience of comprehensive stroke units?

Output: Int J Stroke.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a review of compara-tive evidence and experience of comprehensive stroke units?. ### Response: Int J Stroke..


Instruction: What is the name of the randomized, single-blind trial on the effect of early rehabilitation on daily activities and motor function of patients with hemorrhagic stroke?

Output: A pro-spective, randomized, single-blinded trial on the effect of early rehabilitation on daily activities and motor function of patients with hemorrhagic stroke. J Clin Neurosci. 2012;19:1376–1379. doi: 10.1016/j.jocn.2011.10.021. 323. Cumming TB, Thrift AG, Collier JM, Churilov L, Dewey HM, Donnan GA, Bernhardt J. Very early mobilization after stroke fast-tracks return to walking: further results from the phase II A VERT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized, single-blind trial on the effect of early rehabilitation on daily activities and motor function of patients with hemorrhagic stroke?. ### Response: A pro-spective, randomized, single-blinded trial on the effect of early rehabilitation on daily activities and motor function of patients with hemorrhagic stroke. J Clin Neurosci. 2012;19:1376–1379. doi: 10.1016/j.jocn.2011.10.021. 323. Cumming TB, Thrift AG, Collier JM, Churilov L, Dewey HM, Donnan GA, Bernhardt J. Very early mobilization after stroke fast-tracks return to walking: further results from the phase II A VERT.


Instruction: What is the name of the randomized controlled trial?

Output: phase II A VERT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized controlled trial?. ### Response: phase II A VERT.


Instruction: How many strokes were there in 2012?

Output: 19:1376–1379

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes were there in 2012?. ### Response: 19:1376–1379.


Instruction: What was the outcome of the phase II A VERT?

Output: Very early mobilization after stroke fast-tracks return to walking

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome of the phase II A VERT?. ### Response: Very early mobilization after stroke fast-tracks return to walking.


Instruction: What is ATACH II?

Output: Antihypertensive Treatment of Acute Cerebral Hemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ATACH II?. ### Response: Antihypertensive Treatment of Acute Cerebral Hemorrhage.


Instruction: What is SCORE-IT?

Output: the Spot Sign score in restricting ICH growth

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SCORE-IT?. ### Response: the Spot Sign score in restricting ICH growth.


Instruction: What is the Spot Sign score used for?

Output: restricting ICH growth

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Spot Sign score used for?. ### Response: restricting ICH growth.


Instruction: When was SCORE -IT first used?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was SCORE -IT first used?. ### Response: 2012.


Instruction: How many people were enrolled in the ATACH-II ancillary study?

Output: 325

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were enrolled in the ATACH-II ancillary study?. ### Response: 325.


Instruction: What is the name of the person who saved JL, Starkman S, Eckstein M, Stratton S, Pratt F, Hamilton S, Conwitt F?

Output: Tymianski M

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the person who saved JL, Starkman S, Eckstein M, Stratton S, Pratt F, Hamilton S, Conwitt F?. ### Response: Tymianski M.


Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020?

Output: Limit to  additional study designs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020?. ### Response: Limit to  additional study designs.


Instruction: P age 109 of 127 Question Set # Concept Strategy Question 3 – Methods for risk stratification (cont.)

Output: #10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: P age 109 of 127 Question Set # Concept Strategy Question 3 – Methods for risk stratification (cont.). ### Response: #10.


Instruction: What is the term for a study that is limited to additional study designs?

Output: exp cohort studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for a study that is limited to additional study designs?. ### Response: exp cohort studies.


Instruction: What is another term for an exp cohort study/ OR exp longitudinal studies/OR exp retrospective studies?

Output: prospective studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for an exp cohort study/ OR exp longitudinal studies/OR exp retrospective studies?. ### Response: prospective studies.


Instruction: What is the name of the major clinical study?

Output: OR major clinical study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the major clinical study?. ### Response: OR major clinical study.


Instruction: What is another name for cross -over studies?

Output: crossover procedure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for cross -over studies?. ### Response: crossover procedure.


Instruction: Which study is ti #11?

Output: Diagnostic test hedge

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which study is ti #11?. ### Response: Diagnostic test hedge.


Instruction: What type of curve does ROC curve have?

Output: receiver operating characteristic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of curve does ROC curve have?. ### Response: receiver operating characteristic.


Instruction: What is the name of the curve that has sensitivity and specificity?

Output: ROC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the curve that has sensitivity and specificity?. ### Response: ROC.


Instruction: What does PPV OR stand for?

Output: predictive value of tests

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does PPV OR stand for?. ### Response: predictive value of tests.


Instruction: What is a combination set called?

Output: Simvastatin Drug Combination

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a combination set called?. ### Response: Simvastatin Drug Combination.


Instruction: What does ADJ stand for?

Output: positive  or negative

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ADJ stand for?. ### Response: positive  or negative.


Instruction: What is the name of the pharmacologic treatment?

Output: Dyslipidemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the pharmacologic treatment?. ### Response: Dyslipidemia.


Instruction: Dyslipidemia exp cholesterol/ OR exp lipids/ OR hyperlipidemia* OR dyslipidaemia* Or hypercholesterolemia * OR hyperlipoproteinemia*OR hypertriglyceridemia *OR hyperlipaemia *Or hyperlipiproteinaemia** OR hypertroglyceroidemia* O hyperlipeproteinemia *O hyperlipomeproteinae* OR hyperlesteryl* OR cholesteryl** OR dyslipaemias/OR hyperlipideryl* Oder dyslipiderolemia* Oder hyperlipidaeae

Output: likelihood).de. OR ((false or true) ADJ (positive  or negative)).mp.  #12 Combine sets  #8 AND (#9 OR (#10 AND #11))  #13 Apply limits  See Search Limits at the end of the table  Questions  4, 6, 8, 9 – P ertaining to pharmacologic treatment including cost  #1 Dyslipidemia  exp dyslipidemias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Dyslipidemia exp cholesterol/ OR exp lipids/ OR hyperlipidemia* OR dyslipidaemia* Or hypercholesterolemia * OR hyperlipoproteinemia*OR hypertriglyceridemia *OR hyperlipaemia *Or hyperlipiproteinaemia** OR hypertroglyceroidemia* O hyperlipeproteinemia *O hyperlipomeproteinae* OR hyperlesteryl* OR cholesteryl** OR dyslipaemias/OR hyperlipideryl* Oder dyslipiderolemia* Oder hyperlipidaeae. ### Response: likelihood).de. OR ((false or true) ADJ (positive  or negative)).mp.  #12 Combine sets  #8 AND (#9 OR (#10 AND #11))  #13 Apply limits  See Search Limits at the end of the table  Questions  4, 6, 8, 9 – P ertaining to pharmacologic treatment including cost  #1 Dyslipidemia  exp dyslipidemias.


Instruction: What is hypertriglyceridaemia?

Output: hyperlipemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hypertriglyceridaemia?. ### Response: hyperlipemia.


Instruction: What is cholesteryl?

Output: cholesterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is cholesteryl?. ### Response: cholesterol.


Instruction: What type of disease is exp arterial occlusive?

Output: CVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of disease is exp arterial occlusive?. ### Response: CVD.


Instruction: What is exp brain ischemia?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is exp brain ischemia?. ### Response: stroke.


Instruction: What is an exp peripheral vascular diseases/ OR?

Output: hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an exp peripheral vascular diseases/ OR?. ### Response: hypertension.


Instruction: What is ADJ5 (disease* OR syndrome* OR event* OR ischem* Or ischaem* OR plaque*)

Output: reductase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ADJ5 (disease* OR syndrome* OR event* OR ischem* Or ischaem* OR plaque*). ### Response: reductase.


Instruction: What is another name for heart ADJ attack?

Output: angina

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for heart ADJ attack?. ### Response: angina.


Instruction: What is the other name for myocardial ADJ infarct?

Output: exp myocardial ischemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the other name for myocardial ADJ infarct?. ### Response: exp myocardial ischemia.


Instruction: What is the name of the 2012 Kidney Disease: Improving Global Outcomes Clinical Practice Guideline?

Output: KDIGO

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2012 Kidney Disease: Improving Global Outcomes Clinical Practice Guideline?. ### Response: KDIGO.


Instruction: What does KDIGO stand for?

Output: Kidney Disease: Improving GlobalOutcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does KDIGO stand for?. ### Response: Kidney Disease: Improving GlobalOutcomes.


Instruction: How did guideline development follow?

Output: an explicit process of evidencereview and appraisal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did guideline development follow?. ### Response: an explicit process of evidencereview and appraisal.


Instruction: What is addressed in each chapter of guideline?

Output: Treatment approaches

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is addressed in each chapter of guideline?. ### Response: Treatment approaches.


Instruction: How are guidelinerecommendations based?

Output: systematic reviews of relevant trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are guidelinerecommendations based?. ### Response: systematic reviews of relevant trials.


Instruction: What is the name of the document that discusses controversies and limitations of the evidence?

Output: KDIGO)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the document that discusses controversies and limitations of the evidence?. ### Response: KDIGO).


Instruction: What is the name of the KDIGO Blood Pressure Work Group?

Output: Kidney Disease: Improving GlobalOutcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the KDIGO Blood Pressure Work Group?. ### Response: Kidney Disease: Improving GlobalOutcomes.


Instruction: What should be used for the Kidney Disease: Improving GlobalOutcomes?

Output: Blood Pressure Work Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be used for the Kidney Disease: Improving GlobalOutcomes?. ### Response: Blood Pressure Work Group.


Instruction: What is the 2018 ACHD Guideline?

Output: Stout et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2018 ACHD Guideline?. ### Response: Stout et al.


Instruction: What should clinicians deliver to patients with CHD?

Output: developmentally appropriate transition education

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should clinicians deliver to patients with CHD?. ### Response: developmentally appropriate transition education.


Instruction: Who should deliver developmentally appropriate transition education to adolescent and young patients with CHD and their families/support network?

Output: Clinicians caring for patients with CHD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should deliver developmentally appropriate transition education to adolescent and young patients with CHD and their families/support network?. ### Response: Clinicians caring for patients with CHD.


Instruction: Preparing a patient for independent cardiac care is an ongoing process that should start in what age?

Output: early ado-lescence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Preparing a patient for independent cardiac care is an ongoing process that should start in what age?. ### Response: early ado-lescence.


Instruction: What is the recommen-dation and goals for transition and transition ed-ucation described as?

Output: verbal, written, and experiential efforts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommen-dation and goals for transition and transition ed-ucation described as?. ### Response: verbal, written, and experiential efforts.


Instruction: What do patients and families need to know about their specific heart disease?

Output: ex-pectations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do patients and families need to know about their specific heart disease?. ### Response: ex-pectations.


Instruction: What does lack of education about the need for transition and lifelong cardiac care lead to?

Output: gaps in care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does lack of education about the need for transition and lifelong cardiac care lead to?. ### Response: gaps in care.


Instruction: What can lead to increased hospitaliza-tions?

Output: Lack of education about the need for transition and lifelong cardiac care leads to gaps in care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can lead to increased hospitaliza-tions?. ### Response: Lack of education about the need for transition and lifelong cardiac care leads to gaps in care.


Instruction: What can result in increased hospitaliza-tions, need for urgent intervention, and increased morbidity?

Output: Lack of education about the need for transition and lifelong cardiac care leads to gaps in care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can result in increased hospitaliza-tions, need for urgent intervention, and increased morbidity?. ### Response: Lack of education about the need for transition and lifelong cardiac care leads to gaps in care.


Instruction: A structured approach to transi-tion education improves health related knowledge and self-management.

Output: S3.5-5,S3.5-6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A structured approach to transi-tion education improves health related knowledge and self-management.. ### Response: S3.5-5,S3.5-6.


Instruction: What are SportsRecommendations for Exercise and SportsReferenced studies summarized in?

Output: Online Data Supplement 13

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are SportsRecommendations for Exercise and SportsReferenced studies summarized in?. ### Response: Online Data Supplement 13.


Instruction: What should clinicians assess at regular intervals and counsel patients with ACHD about?

Output: activity levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should clinicians assess at regular intervals and counsel patients with ACHD about?. ### Response: activity levels.


Instruction: What can be useful to guide activity recommendations for patients with ACHD?

Output: CPET

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be useful to guide activity recommendations for patients with ACHD?. ### Response: CPET.


Instruction: Cardiac rehabilitation can be helpful to increase exercise capacity in patients with what condition?

Output: ACHD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cardiac rehabilitation can be helpful to increase exercise capacity in patients with what condition?. ### Response: ACHD.


Instruction: What have patients with CHD focused on instead of promotion of activity?

Output: restriction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have patients with CHD focused on instead of promotion of activity?. ### Response: restriction.


Instruction: Why have rec-ommendations derived from those that apply to competitive sports been applied to recreational activities despite the absence of evidence on the risk or safety of?

Output: Because of fears of adverse events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why have rec-ommendations derived from those that apply to competitive sports been applied to recreational activities despite the absence of evidence on the risk or safety of?. ### Response: Because of fears of adverse events.


Instruction: What is the lack of evidence on the risk or safety of moderate activity?

Output: S3.6-16 have been applied to recreational activities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the lack of evidence on the risk or safety of moderate activity?. ### Response: S3.6-16 have been applied to recreational activities.


Instruction: What does the 2015 “Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 4: Congenital Heart Disease”S3.6-14 work toward?

Output: encouraging participation and shared decision-mak-ing with patients regarding competitive sports partic-ipation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the 2015 “Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 4: Congenital Heart Disease”S3.6-14 work toward?. ### Response: encouraging participation and shared decision-mak-ing with patients regarding competitive sports partic-ipation.


Instruction: Most patients with ACHD can safely what?

Output: engage in regular, moderate physical activity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Most patients with ACHD can safely what?. ### Response: engage in regular, moderate physical activity.


Instruction: What type of activity can most patients with ACHD safely engage in?

Output: regular, moderate physical activity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of activity can most patients with ACHD safely engage in?. ### Response: regular, moderate physical activity.


Instruction: What is a condition that can't be controlled by ACHD?

Output: heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a condition that can't be controlled by ACHD?. ### Response: heart disease.


Instruction: What are some of the key search words included in this guideline?

Output: valvular heart disease, aortic steno-sis, aortic regurgitation, bicuspid aortic valve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the key search words included in this guideline?. ### Response: valvular heart disease, aortic steno-sis, aortic regurgitation, bicuspid aortic valve.


Instruction: What is an example of a valvular heart disease?

Output: aortic steno-sis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a valvular heart disease?. ### Response: aortic steno-sis.


Instruction: What type of regurgita-tion was reviewed by the committee?

Output: pulmonic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of regurgita-tion was reviewed by the committee?. ### Response: pulmonic.


Instruction: What were the references selected and published in this document?

Output: representative and not all-inclusive

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the references selected and published in this document?. ### Response: representative and not all-inclusive.


Instruction: What were the members of the writing committee required to disclose?

Output: all RWI relevant to the data under consideration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the members of the writing committee required to disclose?. ### Response: all RWI relevant to the data under consideration.


Instruction: What was the purpose of document review and approval?

Output: diagnosis and man-agement of adult patients with valvular heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the purpose of document review and approval?. ### Response: diagnosis and man-agement of adult patients with valvular heart disease.


Instruction: How many official reviewers were nominated by the ACC and the AHA?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many official reviewers were nominated by the ACC and the AHA?. ### Response: 2.


Instruction: What was distributed to the writing commit-tee and published in this document?

Output: Reviewers’ RWI information

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was distributed to the writing commit-tee and published in this document?. ### Response: Reviewers’ RWI information.


Instruction: What is the focus of the guideline?

Output: the diagnosis and man-agement of adult patients with valvular heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the focus of the guideline?. ### Response: the diagnosis and man-agement of adult patients with valvular heart disease.


Instruction: When was a full revision of the original 1998 VHD guideline made?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was a full revision of the original 1998 VHD guideline made?. ### Response: 2006.


Instruction: When was a full revision of the guideline made?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was a full revision of the guideline made?. ### Response: 2006.


Instruction: When was an update made to the guide-line made in 2008?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was an update made to the guide-line made in 2008?. ### Response: 2006.


Instruction: What was the name of the statement of clarification for surgery for aortic dilation in patients with BAV?

Output: Scope of the Guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the statement of clarification for surgery for aortic dilation in patients with BAV?. ### Response: Scope of the Guideline.


Instruction: What is BAV?

Output: bicuspid aortic valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is BAV?. ### Response: bicuspid aortic valves.


Instruction: When will the present guideline replace the 2014 guideline and 2017 focused update?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When will the present guideline replace the 2014 guideline and 2017 focused update?. ### Response: April 28, 2023.


Instruction: What has been updated as war-ranted by new evidence or a better understanding?

Output: Some recommendations from the earlier VHD guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been updated as war-ranted by new evidence or a better understanding?. ### Response: Some recommendations from the earlier VHD guidelines.


Instruction: How many mg of sodium is consumed daily?

Output: 2000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mg of sodium is consumed daily?. ### Response: 2000.


Instruction: How many g/d of red meat is consumed per day?

Output: 14

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many g/d of red meat is consumed per day?. ### Response: 14.


Instruction: What type of beverages and processed red meat consumption were associated with cardiovascular death?

Output: sugar-sweetened

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of beverages and processed red meat consumption were associated with cardiovascular death?. ### Response: sugar-sweetened.


Instruction: A prospective cohort study of US healthcare professionals with at least 1 risk factor indicated that replacement of animal protein was associated with what?

Output: reduced cardiovascular mortality rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A prospective cohort study of US healthcare professionals with at least 1 risk factor indicated that replacement of animal protein was associated with what?. ### Response: reduced cardiovascular mortality rate.


Instruction: What was associated with a reduced cardiovascular mortality rate?

Output: replacement of animal protein

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with a reduced cardiovascular mortality rate?. ### Response: replacement of animal protein.


Instruction: What were the sources of cholesterol, saturated fat, heme iron and precursors of trimethylamine-N-oxide?

Output: animal protein

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the sources of cholesterol, saturated fat, heme iron and precursors of trimethylamine-N-oxide?. ### Response: animal protein.


Instruction: How much higher was the mortality rate of poultry and fish compared to plant protein?

Output: 6%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much higher was the mortality rate of poultry and fish compared to plant protein?. ### Response: 6%.


Instruction: How much higher was dairy's mortality rate?

Output: 8%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much higher was dairy's mortality rate?. ### Response: 8%.


Instruction: What was the higher mortality rate of unprocessed red meat?

Output: 12%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the higher mortality rate of unprocessed red meat?. ### Response: 12%.


Instruction: Eggs' mortality rate was what?

Output: 19%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Eggs' mortality rate was what?. ### Response: 19%.


Instruction: Plant protein was associated with a reduction in what percentage of mortality?

Output: 10%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Plant protein was associated with a reduction in what percentage of mortality?. ### Response: 10%.


Instruction: What is the reduction in mortality rate for every 3% energy incre-ment replacement of animal protein?

Output: 10%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the reduction in mortality rate for every 3% energy incre-ment replacement of animal protein?. ### Response: 10%.


Instruction: What has been shown to be potentially harmful or increase risk of ASCVD?

Output: Intake of several food products

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been shown to be potentially harmful or increase risk of ASCVD?. ### Response: Intake of several food products.


Instruction: Sugar-sweetened and artificially sweetened bev-erages have been correlated with increasing the development of what?

Output: T2DM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Sugar-sweetened and artificially sweetened bev-erages have been correlated with increasing the development of what?. ### Response: T2DM.


Instruction: What has been correlated with increasing the development of T2DM and ASCVD risk?

Output: Sugar-sweetened and artificially sweetened bev-erages

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been correlated with increasing the development of T2DM and ASCVD risk?. ### Response: Sugar-sweetened and artificially sweetened bev-erages.


Instruction: How much increase in the frequency of diabetes mellitus with 1 daily serving of sweetened beverages?

Output: 20%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much increase in the frequency of diabetes mellitus with 1 daily serving of sweetened beverages?. ### Response: 20%.


Instruction: In large cohort studies, what has been associated with increased mortality rate?

Output: consump-tion of added sugar

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In large cohort studies, what has been associated with increased mortality rate?. ### Response: consump-tion of added sugar.


Instruction: What has been associated with increased mortality rate?

Output: added sugar

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been associated with increased mortality rate?. ### Response: added sugar.


Instruction: Adults who are habitually high consumers of sugar-sweetened beverages and utilize low calorie sweetened beverages as a replacement strategy may find this useful in the transition to what?

Output: water

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Adults who are habitually high consumers of sugar-sweetened beverages and utilize low calorie sweetened beverages as a replacement strategy may find this useful in the transition to what?. ### Response: water.


Instruction: How much higher is the risk of heart disease in the Southern diet?

Output: 56%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much higher is the risk of heart disease in the Southern diet?. ### Response: 56%.


Instruction: What is the name of the study that identified the Southern dietary pattern as substantially increasing health risks?

Output: REGARDS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that identified the Southern dietary pattern as substantially increasing health risks?. ### Response: REGARDS.


Instruction: How much more risk of stroke is the southern diet associated with?

Output: 30%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much more risk of stroke is the southern diet associated with?. ### Response: 30%.


Instruction: What was the result of a dietS3.1-4 with juices and sweetened beverages, refined grains, potatoes/fries, and sweets?

Output: greater increase in coronary events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the result of a dietS3.1-4 with juices and sweetened beverages, refined grains, potatoes/fries, and sweets?. ### Response: greater increase in coronary events.


Instruction: What was a higher risk of stroke?

Output: 30%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a higher risk of stroke?. ### Response: 30%.


Instruction: What is the risk associated with consumption of animal products?

Output: increased cardiac and noncardiac mortal-ity rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk associated with consumption of animal products?. ### Response: increased cardiac and noncardiac mortal-ity rate.


Instruction: What would clinicians do well to coun-sel individuals about their associated harm and advise them to avoid these foods when possible?

Output: addi-tional risk associated with intake of these various food products

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would clinicians do well to coun-sel individuals about their associated harm and advise them to avoid these foods when possible?. ### Response: addi-tional risk associated with intake of these various food products.


Instruction: Longstanding dietary patterns that focus on low fat diets focus on what?

Output: low intake of carbohydrates and a high intake of animal fat and protein are associated with increased cardiac and noncardiac mortal-ity rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Longstanding dietary patterns that focus on low fat diets focus on what?. ### Response: low intake of carbohydrates and a high intake of animal fat and protein are associated with increased cardiac and noncardiac mortal-ity rate.


Instruction: What are longstanding dietary patterns that focus on low intake of carbohydrates and a high intake of animal fat and protein associated with?

Output: increased cardiac and noncardiac mortal-ity rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are longstanding dietary patterns that focus on low intake of carbohydrates and a high intake of animal fat and protein associated with?. ### Response: increased cardiac and noncardiac mortal-ity rate.


Instruction: Low-carbohydrate diets were associated with a 31% higher risk of all-cause death in 1 meta-analysis?

Output: S3.1-22–S3.1-24 In 1 meta-analysis,S3.1-23 low-carbohydrate diets were associated with a 31% higher risk of all-cause death, with increased cardiac mortality rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Low-carbohydrate diets were associated with a 31% higher risk of all-cause death in 1 meta-analysis?. ### Response: S3.1-22–S3.1-24 In 1 meta-analysis,S3.1-23 low-carbohydrate diets were associated with a 31% higher risk of all-cause death, with increased cardiac mortality rate.


Instruction: How much higher is the risk of all-cause death?

Output: 31%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much higher is the risk of all-cause death?. ### Response: 31%.


Instruction: What is the ARIC?

Output: Atherosclerosis Risk in Communities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ARIC?. ### Response: Atherosclerosis Risk in Communities.


Instruction: How much increased is the cardiac mortality rate?

Output: 18%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much increased is the cardiac mortality rate?. ### Response: 18%.


Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al.


Instruction: When was the 2021 Circulation. 2021:143:e72–e227?

Output: February 2,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the 2021 Circulation. 2021:143:e72–e227?. ### Response: February 2,.


Instruction: What are the reasons for thinking that TAVI might be especially beneficial with severe AS and a low LVEF?

Output: the avoidance of myocardial ischemia with an open surgical procedure and the greater reduction in afterload with a larger effective valve area

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the reasons for thinking that TAVI might be especially beneficial with severe AS and a low LVEF?. ### Response: the avoidance of myocardial ischemia with an open surgical procedure and the greater reduction in afterload with a larger effective valve area.


Instruction: What can be especially beneficial with severe AS and a low LVEF?

Output: TAVI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be especially beneficial with severe AS and a low LVEF?. ### Response: TAVI.


Instruction: The avoidance of myocardial ischemia with an open surgical procedure and the greater reduction in afterload with a larger effective valve area are benefits of what?

Output: TAVI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The avoidance of myocardial ischemia with an open surgical procedure and the greater reduction in afterload with a larger effective valve area are benefits of what?. ### Response: TAVI.


Instruction: What is a risk factor for adverse events?

Output: a low LVEF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for adverse events?. ### Response: a low LVEF.


Instruction: What is a risk factor for adverse outcomes even with TAVI?

Output: a low LVEF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for adverse outcomes even with TAVI?. ### Response: a low LVEF.


Instruction: The final choice of implantation approach is based on a shared decision-making process that accounts for the patient’s values and preferences?

Output: TAVI might be especially beneficial with severe AS and a low LVEF are the avoidance of myocardial ischemia with an open surgical procedure and the greater reduction in afterload with a larger effective valve area. However, outcome data from RCTs show that a low LVEF also is a risk factor for adverse outcomes even with TAVI.29

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The final choice of implantation approach is based on a shared decision-making process that accounts for the patient’s values and preferences?. ### Response: TAVI might be especially beneficial with severe AS and a low LVEF are the avoidance of myocardial ischemia with an open surgical procedure and the greater reduction in afterload with a larger effective valve area. However, outcome data from RCTs show that a low LVEF also is a risk factor for adverse outcomes even with TAVI.29.


Instruction: What are indications for and against each approach and the potential need for and risks associated with valve reintervention?

Output: indica-tions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are indications for and against each approach and the potential need for and risks associated with valve reintervention?. ### Response: indica-tions.


Instruction: Studies on the potential benefit of TAVI in patients with moderate AS and LV systolic dysfunction are in progress what?

Output: 5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Studies on the potential benefit of TAVI in patients with moderate AS and LV systolic dysfunction are in progress what?. ### Response: 5.


Instruction: Published RCTs comparing TAVI and SAVR included only patients with symptoms attrib-utable to severe?

Output: AS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Published RCTs comparing TAVI and SAVR included only patients with symptoms attrib-utable to severe?. ### Response: AS.


Instruction: What did SAVR only include?

Output: patients with symptoms attrib-utable to severe AS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did SAVR only include?. ### Response: patients with symptoms attrib-utable to severe AS.


Instruction: What should asymptomatic patients with COR 2a indications for AVR undergo or wait until a COR 1 indication is present before intervention?

Output: SAVR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should asymptomatic patients with COR 2a indications for AVR undergo or wait until a COR 1 indication is present before intervention?. ### Response: SAVR.


Instruction: What is the final choice of implantation approach based on?

Output: a shared decision-making process

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the final choice of implantation approach based on?. ### Response: a shared decision-making process.


Instruction: What is asymptomatic patients for whom AVR is being considered?

Output: abnormal exercise blood pressure response

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is asymptomatic patients for whom AVR is being considered?. ### Response: abnormal exercise blood pressure response.


Instruction: What is based on a shared decision-making process that accounts for the patient's values and preferences?

Output: The final choice of implantation approach

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is based on a shared decision-making process that accounts for the patient's values and preferences?. ### Response: The final choice of implantation approach.


Instruction: What includes discussion of the indications for and against each approach and the potential need for and risks associated with valve reintervention?

Output: implantation approach

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What includes discussion of the indications for and against each approach and the potential need for and risks associated with valve reintervention?. ### Response: implantation approach.


Instruction: Published RCTs have focused primarily on what?

Output: TAVI via the transfemoral vascular access route

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Published RCTs have focused primarily on what?. ### Response: TAVI via the transfemoral vascular access route.


Instruction: What have published RCTs focused primarily on?

Output: TAVI via the transfemoral vascular access route

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have published RCTs focused primarily on?. ### Response: TAVI via the transfemoral vascular access route.


Instruction: What has the mortality rate been higher with TAVI by nonfemoral access routes than with SAVR?

Output: The mortality rate has been higher with TAVI by nonfemoral access routes than with SAVR, possibly because of the access approach itself, but more likely because of the higher comor -bidity burden

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has the mortality rate been higher with TAVI by nonfemoral access routes than with SAVR?. ### Response: The mortality rate has been higher with TAVI by nonfemoral access routes than with SAVR, possibly because of the access approach itself, but more likely because of the higher comor -bidity burden.


Instruction: When transfemoral TAVI is not fea-sible, SAVR or palliative care options should be included in the shared decision-making discussion?

Output: valve reintervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When transfemoral TAVI is not fea-sible, SAVR or palliative care options should be included in the shared decision-making discussion?. ### Response: valve reintervention.


Instruction: The final choice of implantation approach is based on what?

Output: a shared decision-making process

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The final choice of implantation approach is based on what?. ### Response: a shared decision-making process.


Instruction: What is based on a shared decision-making process that accounts for the patient's values and pref-erences?

Output: The final choice of implantation approach

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is based on a shared decision-making process that accounts for the patient's values and pref-erences?. ### Response: The final choice of implantation approach.


Instruction: What was compared with standard medical therapy in a study?

Output: TAVI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was compared with standard medical therapy in a study?. ### Response: TAVI.


Instruction: What was compared with standard medical therapy in a prospective RCT of patients with severe symptomatic AS who were deemed inop-erable?

Output: TAVI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was compared with standard medical therapy in a prospective RCT of patients with severe symptomatic AS who were deemed inop-erable?. ### Response: TAVI.


Instruction: What was the rate of all-cause death at 2 years?

Output: lower with TAVI (43.3%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the rate of all-cause death at 2 years?. ### Response: lower with TAVI (43.3%).


Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart DiseaseCirculation. 2021;143:e72–e227?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart DiseaseCirculation. 2021;143:e72–e227?. ### Response: Otto et al.


Instruction: What is the current era of surgical reoperation?

Output: 2011–2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the current era of surgical reoperation?. ### Response: 2011–2013.


Instruction: How many patients underwent elective isolated reoperative AVR from 2011-2013?

Output: 3380

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients underwent elective isolated reoperative AVR from 2011-2013?. ### Response: 3380.


Instruction: What was the operative mortality rate of the 3380 patients from the STS database?

Output: 4.6%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the operative mortality rate of the 3380 patients from the STS database?. ### Response: 4.6%.


Instruction: How much higher was the initial AVR's mortality rate?

Output: 4.6% versus 2.2%;

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much higher was the initial AVR's mortality rate?. ### Response: 4.6% versus 2.2%;.


Instruction: How many consecutive patients underwent surgical correction for a non-endocarditis-related aortic or mitral paravalvular leak between 1986 and 2001?

Output: 136

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many consecutive patients underwent surgical correction for a non-endocarditis-related aortic or mitral paravalvular leak between 1986 and 2001?. ### Response: 136.


Instruction: What was the complication rate of initial AVR compared to the initial one?

Output: 2.2%;

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the complication rate of initial AVR compared to the initial one?. ### Response: 2.2%;.


Instruction: What was surgical correction of the paravalvular leak associated with?

Output: acceptable operative mortality (6.6%) and morbidity rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was surgical correction of the paravalvular leak associated with?. ### Response: acceptable operative mortality (6.6%) and morbidity rates.


Instruction: What was the acceptable operative mortality and morbidity rates of surgical correction?

Output: 6.6%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the acceptable operative mortality and morbidity rates of surgical correction?. ### Response: 6.6%).


Instruction: How many patients underwent surgery for paravalveular leak?

Output: 495

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients underwent surgery for paravalveular leak?. ### Response: 495.


Instruction: What is the risk of leak associated with mitral than aortic valve procedures?

Output: higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of leak associated with mitral than aortic valve procedures?. ### Response: higher.


Instruction: What was the 95% confidence interval between 1.25 and 2.20?

Output: 1.66

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 95% confidence interval between 1.25 and 2.20?. ### Response: 1.66.


Instruction: Who reported operative mortality rates of 8% among mitral valve patients?

Output: Bouhout and colleagues

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who reported operative mortality rates of 8% among mitral valve patients?. ### Response: Bouhout and colleagues.


Instruction: How many patients underwent surgery indicated for paravalvular leak?

Output: 495

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients underwent surgery indicated for paravalvular leak?. ### Response: 495.


Instruction: What can be calcu-lated by using the STS risk calculator?

Output: Estimates of operative risk for individual patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be calcu-lated by using the STS risk calculator?. ### Response: Estimates of operative risk for individual patients.


Instruction: How can prosthetic valve deterioration result in regurgitation?

Output: leaflet calcification and non-coaptation or leaflet degeneration with a tear or perforation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can prosthetic valve deterioration result in regurgitation?. ### Response: leaflet calcification and non-coaptation or leaflet degeneration with a tear or perforation.


Instruction: What can result in regurgitation attributable to leaflet calcification?

Output: Prosthetic valve deterioration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can result in regurgitation attributable to leaflet calcification?. ### Response: Prosthetic valve deterioration.


Instruction: Why is valve replacement reasonable even in asymptomatic patients?

Output: the risk of sudden clini-cal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is valve replacement reasonable even in asymptomatic patients?. ### Response: the risk of sudden clini-cal.


Instruction: What risk of sudden clini-cal deterioration occurs if further leaflet tear occurs?

Output: valve replacement is reasonable

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What risk of sudden clini-cal deterioration occurs if further leaflet tear occurs?. ### Response: valve replacement is reasonable.


Instruction: What should be excluded or concurrently treated?

Output: IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be excluded or concurrently treated?. ### Response: IE.


Instruction: What is prudent if a “watchful waiting” approach is taken in asymp-tomatic patients with severe prosthetic valve regurgitation?

Output: referral to a Comprehensive Heart Valve Center

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is prudent if a “watchful waiting” approach is taken in asymp-tomatic patients with severe prosthetic valve regurgitation?. ### Response: referral to a Comprehensive Heart Valve Center.


Instruction: What is the operative risk?

Output: high

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the operative risk?. ### Response: high.


Instruction: What is not feasible in nonrandomized studies?

Output: surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not feasible in nonrandomized studies?. ### Response: surgery.


Instruction: Who supervises the percutaneous para-valvular leak closure?

Output: an MDT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who supervises the percutaneous para-valvular leak closure?. ### Response: an MDT.


Instruction: Where is the MDT located?

Output: Comprehensive Valve Center

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the MDT located?. ### Response: Comprehensive Valve Center.


Instruction: Paravalvular leak closure is typically defined by what?

Output: no more than mild residual regurgitation and the absence of death and major complications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Paravalvular leak closure is typically defined by what?. ### Response: no more than mild residual regurgitation and the absence of death and major complications.


Instruction: What is the absence of death and major complications?

Output: Procedural success rates for percuta-neous paravalvular leak closure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the absence of death and major complications?. ### Response: Procedural success rates for percuta-neous paravalvular leak closure.


Instruction: How many defects were repaired in a large single-center cohort?

Output: 141

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many defects were repaired in a large single-center cohort?. ### Response: 141.


Instruction: What is the name of the meta-analysis of ran-domized trials on the efficacy of vascular closure devices after diagnos-tic angiography and angioplasty?

Output: GOSPEL study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis of ran-domized trials on the efficacy of vascular closure devices after diagnos-tic angiography and angioplasty?. ### Response: GOSPEL study.


Instruction: What are the names of the authors of the Meta-analysis?

Output: Clark AM, Hartling L, Vandermeer B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the authors of the Meta-analysis?. ### Response: Clark AM, Hartling L, Vandermeer B.


Instruction: When was the last decade of Vascular closure devices published?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last decade of Vascular closure devices published?. ### Response: 2007.


Instruction: What year did J Am Coll Cardiol issue 50:1617–26.791?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did J Am Coll Cardiol issue 50:1617–26.791?. ### Response: 2007.


Instruction: What is the name of the systematic review and meta-analysis of arterial puncture closingdevices after cardiac cath-eterization?

Output: JAMA. 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta-analysis of arterial puncture closingdevices after cardiac cath-eterization?. ### Response: JAMA. 2004.


Instruction: When did JAMA issue 291:350–7.792?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did JAMA issue 291:350–7.792?. ### Response: 2004.


Instruction: What year did VascInterv Radiol. 2003:14:865–85.793?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did VascInterv Radiol. 2003:14:865–85.793?. ### Response: 2003.


Instruction: What is the name of the document that the ACCF/ACG/AHA 2010 Expert Consensus Document on the Concomitant Use of?

Output: Proton PumpInhibitors and Thienopyridines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the document that the ACCF/ACG/AHA 2010 Expert Consensus Document on the Concomitant Use of?. ### Response: Proton PumpInhibitors and Thienopyridines.


Instruction: What is a focussed update of the ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastro-intestinal Risks of Antiplatelet Therapy and NSAID Use?

Output: A Report ofthe American College of Cardiology Foundation Task Force on ExpertConsensus Documents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a focussed update of the ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastro-intestinal Risks of Antiplatelet Therapy and NSAID Use?. ### Response: A Report ofthe American College of Cardiology Foundation Task Force on ExpertConsensus Documents.


Instruction: What was a report of the American College of Cardiology Foundation Task Force on ExpertConsense Documents?

Output: Expert Consensus Document

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a report of the American College of Cardiology Foundation Task Force on ExpertConsense Documents?. ### Response: Expert Consensus Document.


Instruction: What did Blankenship JC, Huynh T, et al. evaluate after percutaneous coronary intervention?

Output: routinefunctional testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Blankenship JC, Huynh T, et al. evaluate after percutaneous coronary intervention?. ### Response: routinefunctional testing.


Instruction: What did Goel K, Lennon RJ, Tilbury RT, and Taylor RS do?

Output: cardiac rehabilitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Goel K, Lennon RJ, Tilbury RT, and Taylor RS do?. ### Response: cardiac rehabilitation.


Instruction: What is exercise-based rehabilitation forpatients with coronary heart disease?

Output: systematic review and meta-anal-ysis of randomized controlled trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is exercise-based rehabilitation forpatients with coronary heart disease?. ### Response: systematic review and meta-anal-ysis of randomized controlled trials.


Instruction: What is the name of the systematic review and meta-anal-ysis of randomized controlled trials?

Output: Exercise-based rehabilitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta-anal-ysis of randomized controlled trials?. ### Response: Exercise-based rehabilitation.


Instruction: What is the name of the multicenter, randomized controlled trial from the Italian Cardiac Rehabilitation Network?

Output: GOSPEL study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multicenter, randomized controlled trial from the Italian Cardiac Rehabilitation Network?. ### Response: GOSPEL study.


Instruction: What was the outcome of the GOSPEL study?

Output: Global secondaryprevention strategies to limit event recurrence after myocardial infarc-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome of the GOSPEL study?. ### Response: Global secondaryprevention strategies to limit event recurrence after myocardial infarc-tion.


Instruction: What is a statement for healthcare professionals from theAmerican Heart Association?

Output: Exercise standards fortesting and training

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a statement for healthcare professionals from theAmerican Heart Association?. ### Response: Exercise standards fortesting and training.


Instruction: What is exercise and physical activity in the prevention andtreatment of atherosclerotic cardiovascular disease?

Output: Thompson PD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is exercise and physical activity in the prevention andtreatment of atherosclerotic cardiovascular disease?. ### Response: Thompson PD.


Instruction: What is the name of the journal that studies secondary prevention programs for patients with coronary artery disease?

Output: Meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies secondary prevention programs for patients with coronary artery disease?. ### Response: Meta-analysis.


Instruction: What year did Arterioscler ThrombVasc Biol. 23:1319–21.802?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Arterioscler ThrombVasc Biol. 23:1319–21.802?. ### Response: 2003.


Instruction: When was Circulation. 2021;143:e72–e227?

Output: February 2, 2021

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Circulation. 2021;143:e72–e227?. ### Response: February 2, 2021.


Instruction: What is the DOI of the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: 10.1161/CIR.0000000000000923 e100CLINICAL STATEMENTS  AND GUIDELINES

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the DOI of the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: 10.1161/CIR.0000000000000923 e100CLINICAL STATEMENTS  AND GUIDELINES.


Instruction: What are the approximate ages based on?

Output: US Actuarial Life Expectancy tables

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the approximate ages based on?. ### Response: US Actuarial Life Expectancy tables.


Instruction: What does the balance between expected patient longevity and valve durability vary continuously across the age range?

Output: more durable valves preferred for patients with a longer life expectancy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the balance between expected patient longevity and valve durability vary continuously across the age range?. ### Response: more durable valves preferred for patients with a longer life expectancy.


Instruction: Why are more durable valves preferred for patients with a longer life expectancy?

Output: varies continuously across the age range

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why are more durable valves preferred for patients with a longer life expectancy?. ### Response: varies continuously across the age range.


Instruction: What type of valves are very durable but require lifelong anticoagulation?

Output: mechanical valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of valves are very durable but require lifelong anticoagulation?. ### Response: mechanical valves.


Instruction: How long is the data on outcomes with surgical bioprosthetic valves available?

Output: 20-y

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the data on outcomes with surgical bioprosthetic valves available?. ### Response: 20-y.


Instruction: What is the length of robust data on transcatheter biopropety valves?

Output: 5 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the length of robust data on transcatheter biopropety valves?. ### Response: 5 years.


Instruction: Why are mechanical valves so durable?

Output: require lifelong anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why are mechanical valves so durable?. ### Response: require lifelong anticoagulation.


Instruction: How long does it take for a transcatheter valve to be placed?

Output: 5 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take for a transcatheter valve to be placed?. ### Response: 5 years.


Instruction: What should be individualized on the basis of patient-specific factors that might affect expected longevity?

Output: valve type

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be individualized on the basis of patient-specific factors that might affect expected longevity?. ### Response: valve type.


Instruction: What must be suitable for placement of the prosthetic valve?

Output: Valvular anatomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must be suitable for placement of the prosthetic valve?. ### Response: Valvular anatomy.


Instruction: What indicates aortic stenosis?

Output: ACC Expert Consensus Statement.20 AS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates aortic stenosis?. ### Response: ACC Expert Consensus Statement.20 AS.


Instruction: What does AS mean?

Output: aortic stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does AS mean?. ### Response: aortic stenosis.


Instruction: What does LVEF stand for?

Output: left ventricular ejection fraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does LVEF stand for?. ### Response: left ventricular ejection fraction.


Instruction: Where can you find the Consensus Statement?

Output: ACC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find the Consensus Statement?. ### Response: ACC.


Instruction: What is angiotensin receptor blockade and exercise capacity in adults with systemic right ventricles?

Output: a multicenter, randomized, placebo-controlled clinical trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is angiotensin receptor blockade and exercise capacity in adults with systemic right ventricles?. ### Response: a multicenter, randomized, placebo-controlled clinical trial.


Instruction: What is a multicenter, randomized, placebo-controlled clinical trial?

Output: Angiotensin receptor blockade and exercise capacity in adults with systemic right ventricles

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a multicenter, randomized, placebo-controlled clinical trial?. ### Response: Angiotensin receptor blockade and exercise capacity in adults with systemic right ventricles.


Instruction: What is the effect of angiotensin re-ceptor blockade on systemic right ventricular function and size?

Output: placebo-controlled study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of angiotensin re-ceptor blockade on systemic right ventricular function and size?. ### Response: placebo-controlled study.


Instruction: What did van der Bom T, Winter MM, Bouma BJ, et al. do with valsar -tan?

Output: systemic right ventricular function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did van der Bom T, Winter MM, Bouma BJ, et al. do with valsar -tan?. ### Response: systemic right ventricular function.


Instruction: In what year did Circulation. 2013:127: 322–30?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did Circulation. 2013:127: 322–30?. ### Response: 2005.


Instruction: What is the name of the double-blind, ran-domized, placebo-controlled pilot trial?

Output: S4.4.1.4-13. van der Bom T, Winter MM, Bouma BJ, et al. Effect of valsar -tan on systemic right ventricular function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the double-blind, ran-domized, placebo-controlled pilot trial?. ### Response: S4.4.1.4-13. van der Bom T, Winter MM, Bouma BJ, et al. Effect of valsar -tan on systemic right ventricular function.


Instruction: What is Circulation. 2013;127: 322–30.

Output: a double-blind, ran-domized, placebo-controlled pilot trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Circulation. 2013;127: 322–30.. ### Response: a double-blind, ran-domized, placebo-controlled pilot trial.


Instruction: What are the markers of adverse clinical outcome in adults?

Output: right ven-tricular structural alterations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the markers of adverse clinical outcome in adults?. ### Response: right ven-tricular structural alterations.


Instruction: What is a congenitally cor -rected transposition of the great arteries called?

Output: corrected

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a congenitally cor -rected transposition of the great arteries called?. ### Response: corrected.


Instruction: When was the Am J Cardiol 98: 1277-1282?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Am J Cardiol 98: 1277-1282?. ### Response: 2006.


Instruction: What is the name of the procedure performed in adults with a dysfunctional systemic right ventricle?

Output: Tricuspid valve surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the procedure performed in adults with a dysfunctional systemic right ventricle?. ### Response: Tricuspid valve surgery.


Instruction: What is a Fontan Palliation of Single Ventricle Physiology including Tricuspid Atresia and double inlet left ventricle?

Output: S4.4.2-1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a Fontan Palliation of Single Ventricle Physiology including Tricuspid Atresia and double inlet left ventricle?. ### Response: S4.4.2-1.


Instruction: What type of surgery is Fontan surgery used for?

Output: Single Ventricle Physiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of surgery is Fontan surgery used for?. ### Response: Single Ventricle Physiology.


Instruction: What is the name of the surgery performed by Fontan?

Output: Fontan Palliation of Single Ventricle Physiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the surgery performed by Fontan?. ### Response: Fontan Palliation of Single Ventricle Physiology.


Instruction: Who is the author of the study?

Output: Dulfer K, Duppen N, Blom NA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of the study?. ### Response: Dulfer K, Duppen N, Blom NA.


Instruction: What is the difference between cavopulmonary and aortopulmonary shunts for adults with single ventricle physiology?

Output: Definitive palliation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between cavopulmonary and aortopulmonary shunts for adults with single ventricle physiology?. ### Response: Definitive palliation.


Instruction: What does Cordina R, O’Meagher S, Gould H, et al. have in adults with Fontan circulation?

Output: Skeletal muscle abnor -malities and exercise capacity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Cordina R, O’Meagher S, Gould H, et al. have in adults with Fontan circulation?. ### Response: Skeletal muscle abnor -malities and exercise capacity.


Instruction: S4.4.2-4. Dulfer K, Duppen N, Blom NA, et al. Effects of exercise training on behavioral and emotional problems in adolescents with tetralogy of Fallot or a Fontan circulation: a randomized controlled trial?

Output: heart transplantation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: S4.4.2-4. Dulfer K, Duppen N, Blom NA, et al. Effects of exercise training on behavioral and emotional problems in adolescents with tetralogy of Fallot or a Fontan circulation: a randomized controlled trial?. ### Response: heart transplantation.


Instruction: Inai K, Saita Y, Takeda S, and Saiti Y. Skeletal muscle hemodynamics and what else?

Output: endothelial function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Inai K, Saita Y, Takeda S, and Saiti Y. Skeletal muscle hemodynamics and what else?. ### Response: endothelial function.


Instruction: What type of muscle hemodynamics and endothelial function do patients after Fontan operation have?

Output: Skeletal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of muscle hemodynamics and endothelial function do patients after Fontan operation have?. ### Response: Skeletal.


Instruction: What is the name of the 2007 study that examined the hepatic changes in the failing Fontan circulation?

Output: Heart

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2007 study that examined the hepatic changes in the failing Fontan circulation?. ### Response: Heart.


Instruction: Who is the author of this study?

Output: Dulfer K, Duppen N, Blom NA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of this study?. ### Response: Dulfer K, Duppen N, Blom NA.


Instruction: What is a good option for complex congenital heart disease?

Output: heart transplantation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a good option for complex congenital heart disease?. ### Response: heart transplantation.


Instruction: How long has a single centre experience with heart transplantation?

Output: 25-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long has a single centre experience with heart transplantation?. ### Response: 25-year.


Instruction: Eur J Cardiothorac Surg. 2013;43: 605-11.

Output: heart transplantation for complex congenital heart disease a good option? A 25-year single centre experience. Eur J Cardiothorac Surg. 2013;43: 605–11. S4.4.2-8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Eur J Cardiothorac Surg. 2013;43: 605-11.. ### Response: heart transplantation for complex congenital heart disease a good option? A 25-year single centre experience. Eur J Cardiothorac Surg. 2013;43: 605–11. S4.4.2-8.


Instruction: What is the phenotype of Fontan in an adult population?

Output: Hemodynamic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the phenotype of Fontan in an adult population?. ### Response: Hemodynamic.


Instruction: What is the name of the failing Fontan in an adult population?

Output: tetralogy of Fallot

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the failing Fontan in an adult population?. ### Response: tetralogy of Fallot.


Instruction: What year did Am J Cardiol. 2013:112:1943–7?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Am J Cardiol. 2013:112:1943–7?. ### Response: 2007.


Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020 Page 122 of 127 63?

Output: 29777433

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020 Page 122 of 127 63?. ### Response: 29777433.


Instruction: What is a meta-analysis of randomized controlled trials?

Output: Hydrophilic vs lipophilic statins in coronary artery disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a meta-analysis of randomized controlled trials?. ### Response: Hydrophilic vs lipophilic statins in coronary artery disease.


Instruction: What is ezetimibe used for in chronic kidney disease patients?

Output: statin versus statin titration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ezetimibe used for in chronic kidney disease patients?. ### Response: statin versus statin titration.


Instruction: What is the name of the randomized controlled trial?

Output: Study of Heart and Renal Protection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized controlled trial?. ### Response: Study of Heart and Renal Protection.


Instruction: When did the J Clin Lipidol issue 11(3):624- 637?

Output: May - Jun 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the J Clin Lipidol issue 11(3):624- 637?. ### Response: May - Jun 2017.


Instruction: What is ezetimibe used for in patients with hypercholesterolaemia?

Output: statin vs statin titration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ezetimibe used for in patients with hypercholesterolaemia?. ### Response: statin vs statin titration.


Instruction: What is the name of the study that evaluated the efficacy of the addition of statin to statin vs statin?

Output: Study of Heart and Renal Protection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated the efficacy of the addition of statin to statin vs statin?. ### Response: Study of Heart and Renal Protection.


Instruction: When did Ther Adv Cardiovasc Dis. 7(6):306-315?

Output: Dec 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Ther Adv Cardiovasc Dis. 7(6):306-315?. ### Response: Dec 2013.


Instruction: What is the name of the systematic review and meta-analysis?

Output: Curr Med Res Opin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta-analysis?. ### Response: Curr Med Res Opin.


Instruction: When did Curr Med Res Opin issue 27(6):1191 -1210?

Output: Jun 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Curr Med Res Opin issue 27(6):1191 -1210?. ### Response: Jun 2011.


Instruction: What is ezetimibe?

Output: chronic kidney disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ezetimibe?. ### Response: chronic kidney disease.


Instruction: How does simvastatin lower LDL cholesterol?

Output: statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does simvastatin lower LDL cholesterol?. ### Response: statin therapy.