Instruction: What does whole blood heparin concen-tration monitoring result in?

Output: larger doses of unfractio-nated heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does whole blood heparin concen-tration monitoring result in?. ### Response: larger doses of unfractio-nated heparin.


Instruction: What does ACT monitoring do?

Output: improved hemostaticsuppression

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ACT monitoring do?. ### Response: improved hemostaticsuppression.


Instruction: How many patients participated in a retrospective analysis?

Output: 686

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients participated in a retrospective analysis?. ### Response: 686.


Instruction: Why did patients prefer ACT-based monitoring over heparin concentration monitoring?

Output: less post-operative bleeding and transfusion requirements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why did patients prefer ACT-based monitoring over heparin concentration monitoring?. ### Response: less post-operative bleeding and transfusion requirements.


Instruction: What are the benefits of ACT based monitoring compared to ACT?

Output: less post-operative bleeding and transfusion requirements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the benefits of ACT based monitoring compared to ACT?. ### Response: less post-operative bleeding and transfusion requirements.


Instruction: Who wrote about ANTICOAGULATION DURING CARDIOPULMONARY?

Output: Ann Thorac Surg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote about ANTICOAGULATION DURING CARDIOPULMONARY?. ### Response: Ann Thorac Surg.


Instruction: What year was the Collaborative Transplant Study conducted?

Output: 1998

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the Collaborative Transplant Study conducted?. ### Response: 1998.


Instruction: What is the name of the study that correlated chronic kidney graft failure with recipient blood pressure?

Output: Collaborative Transplant Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that correlated chronic kidney graft failure with recipient blood pressure?. ### Response: Collaborative Transplant Study.


Instruction: What is the KDIGO Transplant Work Group's clinical practice guideline for thecare of patients with kidney transplantation?

Output: Am J Kidney Dis 2004; 43: 1071– 1081.292. KDIGO Transplant Work Group. KDIGO clinical practice guideline for thecare of kidney transplant recipients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the KDIGO Transplant Work Group's clinical practice guideline for thecare of patients with kidney transplantation?. ### Response: Am J Kidney Dis 2004; 43: 1071– 1081.292. KDIGO Transplant Work Group. KDIGO clinical practice guideline for thecare of kidney transplant recipients.


Instruction: What are the results of renal transplantation associated with?

Output: blood pressure control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of renal transplantation associated with?. ### Response: blood pressure control.


Instruction: When was the Am J Transplant 2005 published?

Output: 5:2725– 2731.291

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Am J Transplant 2005 published?. ### Response: 5:2725– 2731.291.


Instruction: What is the KDIGO clinical practice guideline for thecare of kidney transplant recipients?

Output: KDIGO Transplant Work Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the KDIGO clinical practice guideline for thecare of kidney transplant recipients?. ### Response: KDIGO Transplant Work Group.


Instruction: What type of MRI is used after specialist assessment in TIA clinic?

Output: diffusion-w eight ed and blood-sensitiv e sequences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of MRI is used after specialist assessment in TIA clinic?. ### Response: diffusion-w eight ed and blood-sensitiv e sequences.


Instruction: What is MRI used for?

Output: specialist assessment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is MRI used for?. ### Response: specialist assessment.


Instruction: What is done on the same da y as t he assessment?

Output: MRI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is done on the same da y as t he assessment?. ### Response: MRI.


Instruction: What is a shor t explanation of wh y the committ ee made?

Output: t hese r ecommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a shor t explanation of wh y the committ ee made?. ### Response: t hese r ecommendations.


Instruction: What is t he rationale and impact section on TIA imaging for?

Output: people who ha ve had a suspect ed TIA or acut e non-disabling str oke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is t he rationale and impact section on TIA imaging for?. ### Response: people who ha ve had a suspect ed TIA or acut e non-disabling str oke.


Instruction: Who has had a suspect ed or acut e non-disabling str oke?

Output: people wit h stable neur ological sympt oms fr om acut e non-disabling str oke or TIA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who has had a suspect ed or acut e non-disabling str oke?. ### Response: people wit h stable neur ological sympt oms fr om acut e non-disabling str oke or TIA.


Instruction: Who should have urgent car otid imaging?

Output: Everyone wit h TIA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should have urgent car otid imaging?. ### Response: Everyone wit h TIA.


Instruction: What is otid imaging?

Output: urgent car

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is otid imaging?. ### Response: urgent car.


Instruction: What is Urgent carotid endar terectomy 1.2.4 Ensur e that people wit h stable neurological sympt oms from acut e non-disabling str oke or TIA have?

Output: sympt omatic car otid st enosis of 50% to 99%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Urgent carotid endar terectomy 1.2.4 Ensur e that people wit h stable neurological sympt oms from acut e non-disabling str oke or TIA have?. ### Response: sympt omatic car otid st enosis of 50% to 99%.


Instruction: How much to 99% according to the NASCET?

Output: 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much to 99% according to the NASCET?. ### Response: 50%.


Instruction: What is the accor ding to the NASCET?

Output: 50% to 99%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the accor ding to the NASCET?. ### Response: 50% to 99%.


Instruction: How much to 99% of the participants are ac oding?

Output: 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much to 99% of the participants are ac oding?. ### Response: 50%.


Instruction: What is a crit eria for the nascte?

Output: less than 50% accor ding t o the NASCET

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a crit eria for the nascte?. ### Response: less than 50% accor ding t o the NASCET.


Instruction: What is curr ent national standar ds?

Output: NHS England and NHS Improvement National Str oke Ser vice Model

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is curr ent national standar ds?. ### Response: NHS England and NHS Improvement National Str oke Ser vice Model.


Instruction: What is the best medical tr eatment?

Output: contr ol of blood pr essur e, antiplat elet agent s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the best medical tr eatment?. ### Response: contr ol of blood pr essur e, antiplat elet agent s.


Instruction: What do people with stable neurological sympt oms have?

Output: sympt omatic car otid st enosis of less than 50% accor ding t o the NASCET crit eria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do people with stable neurological sympt oms have?. ### Response: sympt omatic car otid st enosis of less than 50% accor ding t o the NASCET crit eria.


Instruction: What does diet and drugs help people with?

Output: cholest erol lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does diet and drugs help people with?. ### Response: cholest erol lowering.


Instruction: What is the NASCET criteria for car otid st enosis?

Output: less than 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the NASCET criteria for car otid st enosis?. ### Response: less than 50%.


Instruction: Stroke and transient ischaemic attack in o ver 16s: diagnosis and initial management(NG128) NICE 2023?

Output: All right s reserved

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Stroke and transient ischaemic attack in o ver 16s: diagnosis and initial management(NG128) NICE 2023?. ### Response: All right s reserved.


Instruction: What is the subject of Notice of right s?

Output: All right s reserved

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the subject of Notice of right s?. ### Response: All right s reserved.


Instruction: When was the last updat ed?

Output: 13 April 2022

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last updat ed?. ### Response: 13 April 2022.


Instruction: What did Kulik et al document as a result of secondary prevention after CABG 937therapy among CABG patients?

Output: improved 30-day mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Kulik et al document as a result of secondary prevention after CABG 937therapy among CABG patients?. ### Response: improved 30-day mortality.


Instruction: What was documented as an association between preoperative -blocker therapy and improved 30-day mortality?

Output: Kulik et al  Secondary Prevention After CABG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was documented as an association between preoperative -blocker therapy and improved 30-day mortality?. ### Response: Kulik et al  Secondary Prevention After CABG.


Instruction: How many patients were evaluated in the Society of Thoracic Surgeons Database from 1996 to 1999?

Output: >600 000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were evaluated in the Society of Thoracic Surgeons Database from 1996 to 1999?. ### Response: >600 000.


Instruction: When did the authors note that patients who received -blockers before surgery had significantly lower 30-day mor -tality rates than those who did not?

Output: 1996 to 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the authors note that patients who received -blockers before surgery had significantly lower 30-day mor -tality rates than those who did not?. ### Response: 1996 to 1999.


Instruction: What was the adjusted OR of patients who had received a  blocker before surgery?

Output: 0.94

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the adjusted OR of patients who had received a  blocker before surgery?. ### Response: 0.94.


Instruction: When did a number of quality-improvement projects emerge to link sec-ondary prevention?

Output: early-to-mid-2000s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did a number of quality-improvement projects emerge to link sec-ondary prevention?. ### Response: early-to-mid-2000s.


Instruction: When did projects emerge to link sec-ondary prevention and -blockade therapy in CABG?

Output: early-to-mid-2000s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did projects emerge to link sec-ondary prevention and -blockade therapy in CABG?. ### Response: early-to-mid-2000s.


Instruction: What did these studies create the environment for attention to and adoption of?

Output: β-blocker therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did these studies create the environment for attention to and adoption of?. ### Response: β-blocker therapy.


Instruction: According to Foody et al, what percentage of CABG patients received  blocker therapy after presenting with a condition?

Output: 61.5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: According to Foody et al, what percentage of CABG patients received  blocker therapy after presenting with a condition?. ### Response: 61.5%.


Instruction: What percentage of CABG patients received -blocker therapy after presenting with MI between 1998 and 1999?

Output: 61.5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of CABG patients received -blocker therapy after presenting with MI between 1998 and 1999?. ### Response: 61.5%.


Instruction: What did this study lay the foundation for?

Output: establishing baseline secondary prevention benchmarks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did this study lay the foundation for?. ### Response: establishing baseline secondary prevention benchmarks.


Instruction: What did the Alabama CABG project demonstrate?

Output: an increase in β-blocker therapy at discharge from 65% to 78%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Alabama CABG project demonstrate?. ### Response: an increase in β-blocker therapy at discharge from 65% to 78%.


Instruction: What was the increase in post discharge -blocker therapy?

Output: 65% to 78%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the increase in post discharge -blocker therapy?. ### Response: 65% to 78%.


Instruction: What was the adherence rate at discharge over a 2-year period?

Output: 78%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the adherence rate at discharge over a 2-year period?. ### Response: 78%.


Instruction: What did Williams et al193 report a significant increase in for all secondary preven-tion medications, including -blocker therapy?

Output: adherence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Williams et al193 report a significant increase in for all secondary preven-tion medications, including -blocker therapy?. ### Response: adherence.


Instruction: What percentage of patients were discharged on -blocker after CABG?

Output: 90.8%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients were discharged on -blocker after CABG?. ### Response: 90.8%.


Instruction: What was the University of Kentucky able to improve its use of?

Output: β-blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the University of Kentucky able to improve its use of?. ### Response: β-blocker.


Instruction: What percentage of patients were discharged on -blocker therapy after CABG?

Output: 90.8%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients were discharged on -blocker therapy after CABG?. ### Response: 90.8%.


Instruction: How many studies were limited by their observational nature?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were limited by their observational nature?. ### Response: 1.


Instruction: In what year did Sjoland conduct a randomized trial?

Output: 1995

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did Sjoland conduct a randomized trial?. ### Response: 1995.


Instruction: When did Sjoland et al conduct a double-blind, placebo-controlled, randomized, controlled trial of 967 patients?

Output: 1995

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Sjoland et al conduct a double-blind, placebo-controlled, randomized, controlled trial of 967 patients?. ### Response: 1995.


Instruction: How many patients were randomized 4 to 21 days after CABG to 50 mg meto-prolol twice a day for 2 weeks?

Output: 967

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were randomized 4 to 21 days after CABG to 50 mg meto-prolol twice a day for 2 weeks?. ### Response: 967.


Instruction: How much metoprolol did the researchers take twice a day for 2 weeks?

Output: 100 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much metoprolol did the researchers take twice a day for 2 weeks?. ### Response: 100 mg.


Instruction: How long did it take to take 100 mg of metotroprololl twice daily versus placebo for 2 years?

Output: 2 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take to take 100 mg of metotroprololl twice daily versus placebo for 2 years?. ### Response: 2 weeks.


Instruction: What did the authors find in the 2 arms of the trial?

Output: no difference between the 2 arms of the trial with respect to the risk of death or the development of cardiac events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the authors find in the 2 arms of the trial?. ### Response: no difference between the 2 arms of the trial with respect to the risk of death or the development of cardiac events.


Instruction: The authors found no difference in the risk of death or the development of what?

Output: cardiac events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The authors found no difference in the risk of death or the development of what?. ### Response: cardiac events.


Instruction: How many people were enrolled in the study?

Output: 967

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were enrolled in the study?. ### Response: 967.


Instruction: What did the study show about exercise capacity?

Output: no improvement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the study show about exercise capacity?. ### Response: no improvement.


Instruction: What is the 2020 ACC/AHA Guideline for the Management of Valvular Heart DiseaseCirculation. 2021;143:e72–e227?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2020 ACC/AHA Guideline for the Management of Valvular Heart DiseaseCirculation. 2021;143:e72–e227?. ### Response: Otto et al.


Instruction: What are the Referenced studies that support the recommendations summarized in?

Output: Online Data Supplement 31.COR LOE Recommendations2a B-R1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Referenced studies that support the recommendations summarized in?. ### Response: Online Data Supplement 31.COR LOE Recommendations2a B-R1.


Instruction: What is TEER reasonable in patients with appropriate anatomy as defined on TEE?

Output: chronic severe secondary MR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is TEER reasonable in patients with appropriate anatomy as defined on TEE?. ### Response: chronic severe secondary MR.


Instruction: What is the LVEF 50%?

Output: ≥50%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the LVEF 50%?. ### Response: ≥50%).


Instruction: What is reasonable in patients with appropriate anatomy as defined on TEE and with LVEF between 20% and 50%, LVESD 70 mm Hg.1–82a B-NR2?

Output: TEER

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable in patients with appropriate anatomy as defined on TEE and with LVEF between 20% and 50%, LVESD 70 mm Hg.1–82a B-NR2?. ### Response: TEER.


Instruction: In patients with severe secondary MR (Stages C and D), what is reasonable when CABG is undertaken?

Output: mitral valve surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with severe secondary MR (Stages C and D), what is reasonable when CABG is undertaken?. ### Response: mitral valve surgery.


Instruction: What is reasonable when CABG is undertaken for the treatment of myocardial ischemia?

Output: mitral valve surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable when CABG is undertaken for the treatment of myocardial ischemia?. ### Response: mitral valve surgery.


Instruction: What type of surgery is reasonable in patients with chronic severe secondary MR from atrial annular dilation?

Output: mitral valve surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of surgery is reasonable in patients with chronic severe secondary MR from atrial annular dilation?. ### Response: mitral valve surgery.


Instruction: What type of surgery may be considered in patients with HF and associated AF?

Output: mitral valve surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of surgery may be considered in patients with HF and associated AF?. ### Response: mitral valve surgery.


Instruction: In patients with chronic severe secondary MR related to LV systolic dysfunction who have persistent severe symptoms, what type of valve surgery is considered?

Output: mitral

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with chronic severe secondary MR related to LV systolic dysfunction who have persistent severe symptoms, what type of valve surgery is considered?. ### Response: mitral.


Instruction: What type of valve surgery may be considered in patients with persistent severe symptoms?

Output: mitral

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of valve surgery may be considered in patients with persistent severe symptoms?. ### Response: mitral.


Instruction: What is the stage D of LV systolic dysfunction?

Output: LVEF <50%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the stage D of LV systolic dysfunction?. ### Response: LVEF <50%).


Instruction: What percentage of dysfunction is present in Stage D patients undergoing mitral valve surgery?

Output: <50%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of dysfunction is present in Stage D patients undergoing mitral valve surgery?. ### Response: <50%).


Instruction: What type of valve replacement may be reasonable to choose over downsized annuloplasty repair?

Output: mitral

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of valve replacement may be reasonable to choose over downsized annuloplasty repair?. ### Response: mitral.


Instruction: What is indicated to improve symptoms and pro-long life in a select subset of patients with chronic se-vere secondary MR, LV systolic dysfunction, and persis-tent severe symptoms?

Output: Mitral TEER

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is indicated to improve symptoms and pro-long life in a select subset of patients with chronic se-vere secondary MR, LV systolic dysfunction, and persis-tent severe symptoms?. ### Response: Mitral TEER.


Instruction: Surgery may improve symptoms in patients with what?

Output: se-vere secondary MR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Surgery may improve symptoms in patients with what?. ### Response: se-vere secondary MR.


Instruction: What is preferred over repair?

Output: mitral valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is preferred over repair?. ### Response: mitral valve replacement.


Instruction: What may a subset of patients with severe MR attributable to AF benefit from?

Output: mitral valve surgery and concomitant atrial maze procedure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may a subset of patients with severe MR attributable to AF benefit from?. ### Response: mitral valve surgery and concomitant atrial maze procedure.


Instruction: The COAPT trial demonstrated improvement in sur-vival, hospitalization, symptoms, and what else?

Output: quality of life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The COAPT trial demonstrated improvement in sur-vival, hospitalization, symptoms, and what else?. ### Response: quality of life.


Instruction: What is MITRA-FR?

Output: Multicentre Randomized Study of Percutaneous Mitral Valve Repair MitraClip Device in Patients With Severe Secondary Mitral Regurgitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is MITRA-FR?. ### Response: Multicentre Randomized Study of Percutaneous Mitral Valve Repair MitraClip Device in Patients With Severe Secondary Mitral Regurgitation.


Instruction: What type of GDMT did patients with persistent symptoms receive?

Output: Stage D

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of GDMT did patients with persistent symptoms receive?. ### Response: Stage D.


Instruction: What is the name of the device used to repair patients with severe secondary mitral regurgitation?

Output: Percutaneous Mitral Valve Repair MitraClip Device

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the device used to repair patients with severe secondary mitral regurgitation?. ### Response: Percutaneous Mitral Valve Repair MitraClip Device.


Instruction: Patients with greater degrees of LV enlargement were enrolled with what?

Output: MITRA-FR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with greater degrees of LV enlargement were enrolled with what?. ### Response: MITRA-FR.


Instruction: What should be the basis of a care plan for ea ch person?

Output: The summary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be the basis of a care plan for ea ch person?. ### Response: The summary.


Instruction: What should include:  plans for managing a person's health?

Output: Give a copy of the care plan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should include:  plans for managing a person's health?. ### Response: Give a copy of the care plan.


Instruction: What should be included in the plan for managing the person’s heart failure?

Output: Give a copy of the care plan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be included in the plan for managing the person’s heart failure?. ### Response: Give a copy of the care plan.


Instruction: What should the plan include?

Output:  plans for managing the person’s heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should the plan include?. ### Response:  plans for managing the person’s heart failure.


Instruction: What is the name of a named healthcare coordinator?

Output: a specialist heart failure nurse

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of a named healthcare coordinator?. ### Response: a specialist heart failure nurse.


Instruction: What is another name for a specialist heart failure nurse?

Output: healthcare coordinator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for a specialist heart failure nurse?. ### Response: healthcare coordinator.


Instruction: What is another term for care or review?

Output: urgent care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for care or review?. ### Response: urgent care.


Instruction: What are additional sources of information for people with heart failure?

Output: specialis t services

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are additional sources of information for people with heart failure?. ### Response: specialis t services.


Instruction: Give a copy of the care plan to who?

Output: the person with heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Give a copy of the care plan to who?. ### Response: the person with heart failure.


Instruction: What is the NICE Guideline CG138?

Output: Patient experience in adult NHS services

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the NICE Guideline CG138?. ### Response: Patient experience in adult NHS services.


Instruction: How many subfindings were found in the review?

Output: five

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many subfindings were found in the review?. ### Response: five.


Instruction: What was the structure of the recommendations on continuity of care?

Output: NICE Guideline CG138

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the structure of the recommendations on continuity of care?. ### Response: NICE Guideline CG138.


Instruction: How many aspects of continuity of care were identified in CG138?

Output: four

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many aspects of continuity of care were identified in CG138?. ### Response: four.


Instruction: What was identified as an important aspect of continuity care for people with special needs?

Output: individualised, holistic care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was identified as an important aspect of continuity care for people with special needs?. ### Response: individualised, holistic care.


Instruction: How many subfindings of continuity of care did the review identify challenges and suggestions for improvement?

Output: five

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many subfindings of continuity of care did the review identify challenges and suggestions for improvement?. ### Response: five.


Instruction: What could transition in heart failure care affect patients and patient care?

Output: peoples confidence in their management plans

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could transition in heart failure care affect patients and patient care?. ### Response: peoples confidence in their management plans.


Instruction: What could affect patients and patient care?

Output: transition in heart failure care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could affect patients and patient care?. ### Response: transition in heart failure care.


Instruction: What guidelines were identified as covering similar findings on the management of diseases?

Output: NICE Guideline CG138

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What guidelines were identified as covering similar findings on the management of diseases?. ### Response: NICE Guideline CG138.


Instruction: What was found to be a negative effect on peoples confidence in their health care?

Output: heart failure care that is spread across different healthcare settings is fragmented

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was found to be a negative effect on peoples confidence in their health care?. ### Response: heart failure care that is spread across different healthcare settings is fragmented.


Instruction: What is spread across different healthcare settings?

Output: heart failure care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is spread across different healthcare settings?. ### Response: heart failure care.


Instruction: What can have a negative effect on peoples confidence in their management plans?

Output: heart failure care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can have a negative effect on peoples confidence in their management plans?. ### Response: heart failure care.


Instruction: What was good at providing continuity of care and individualised, holistic care?

Output: primary healthcare services, and especially general practitioners

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was good at providing continuity of care and individualised, holistic care?. ### Response: primary healthcare services, and especially general practitioners.


Instruction: What should be attempted to integrate into existing primary care structures?

Output: specialist services

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be attempted to integrate into existing primary care structures?. ### Response: specialist services.


Instruction: Evidence showed that discharge from HF specialist services to general practice can be seen as what by patients?

Output: loss

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Evidence showed that discharge from HF specialist services to general practice can be seen as what by patients?. ### Response: loss.


Instruction: The reasons for this were thought to be multifactorial and concerned what?

Output: the difference between specialist and GP care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The reasons for this were thought to be multifactorial and concerned what?. ### Response: the difference between specialist and GP care.


Instruction: What was the difference between specialist and GP care?

Output: a real or perceived reduction in the focus on the condition

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the difference between specialist and GP care?. ### Response: a real or perceived reduction in the focus on the condition.


Instruction: What was a real or perceived reduction in focus on the condition?

Output: reduced awareness of the intricacies of the condition

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a real or perceived reduction in focus on the condition?. ### Response: reduced awareness of the intricacies of the condition.


Instruction: Who published the 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary?

Output: Arnett et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary?. ### Response: Arnett et al.


Instruction: What is the name of the guideline that was published on September 10, 2019?

Output: ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the guideline that was published on September 10, 2019?. ### Response: ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease.


Instruction: What is the name of the procedure that bypasses the artery?

Output: Coronary artery bypass

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the procedure that bypasses the artery?. ### Response: Coronary artery bypass.


Instruction: What type of revascularization procedure is used to treat heart failure?

Output: erebrovascular disorders

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of revascularization procedure is used to treat heart failure?. ### Response: erebrovascular disorders.


Instruction: What type of infarction is caused by heart failure?

Output: Myocardial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of infarction is caused by heart failure?. ### Response: Myocardial.


Instruction: What is the name of the test that measures exercise tolerance?

Output: Graded exercise test

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the test that measures exercise tolerance?. ### Response: Graded exercise test.


Instruction: How is angina defined?

Output: Unstable

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is angina defined?. ### Response: Unstable.


Instruction: What is a no reflow phenomenon?

Output: Heart Arrest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a no reflow phenomenon?. ### Response: Heart Arrest.


Instruction: What is another name for Heart Arrest?

Output: Heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for Heart Arrest?. ### Response: Heart failure.


Instruction: What is anastomosis in the mammary artery?

Output: Angioplasty "angioplasty transluminal percutaneous coronary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is anastomosis in the mammary artery?. ### Response: Angioplasty "angioplasty transluminal percutaneous coronary.


Instruction: What is the name of the procedure used to treat heart failure?

Output: Hospitalization Hospitalization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the procedure used to treat heart failure?. ### Response: Hospitalization Hospitalization.


Instruction: How is the heart failure treated?

Output: Hospitalization Hospitalization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the heart failure treated?. ### Response: Hospitalization Hospitalization.


Instruction: What is a result of endothelial dysfunction and decreased nitric oxide avail-ability related to mechanical and inflammatory injury of arter-ies?

Output: increased arterial stiffness and the development of isolated systolic hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a result of endothelial dysfunction and decreased nitric oxide avail-ability related to mechanical and inflammatory injury of arter-ies?. ### Response: increased arterial stiffness and the development of isolated systolic hypertension.


Instruction: What is associated with increased arterial stiffness and the development of isolated systolic hypertension?

Output: Endothelial dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with increased arterial stiffness and the development of isolated systolic hypertension?. ### Response: Endothelial dysfunction.


Instruction: A decline in flow-mediated vasodilator capacity attributable to decreased endothelium-derived nitrate occurs in what?

Output: aging and subclini-cal vascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A decline in flow-mediated vasodilator capacity attributable to decreased endothelium-derived nitrate occurs in what?. ### Response: aging and subclini-cal vascular disease.


Instruction: What is responsible for the exaggerated exercise-induced increases in BP seen in these population groups?

Output: Impaired endothelium-mediated vaso-dilation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is responsible for the exaggerated exercise-induced increases in BP seen in these population groups?. ### Response: Impaired endothelium-mediated vaso-dilation.


Instruction: What is a critical feature of both hypertension and atherogenesis?

Output: Oxidative stress

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a critical feature of both hypertension and atherogenesis?. ### Response: Oxidative stress.


Instruction: What are the principal effectors of oxidative injury in vascular tissue?

Output: NAD(P)H oxidases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the principal effectors of oxidative injury in vascular tissue?. ### Response: NAD(P)H oxidases.


Instruction: What are NAD(P)H oxidases acti-vated by?

Output: Angiotensin II

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are NAD(P)H oxidases acti-vated by?. ### Response: Angiotensin II.


Instruction: In what setting are several isoforms expressed in endo-thelial and vascular smooth muscle cells upregulated in the setting of atherosclerosis?

Output: NAD(P)H oxidase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what setting are several isoforms expressed in endo-thelial and vascular smooth muscle cells upregulated in the setting of atherosclerosis?. ### Response: NAD(P)H oxidase.


Instruction: What is upregulated in the setting of atherosclerosis and arterial injury?

Output: NAD(P)H oxidase isoforms expressed in endo-thelial and vascular smooth muscle cells

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is upregulated in the setting of atherosclerosis and arterial injury?. ### Response: NAD(P)H oxidase isoforms expressed in endo-thelial and vascular smooth muscle cells.


Instruction: Angiotensin II receptor-dependent activation of NAD(P)H oxidase stim-ulates formation of what?

Output: low-density lipoprotein cholesterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Angiotensin II receptor-dependent activation of NAD(P)H oxidase stim-ulates formation of what?. ### Response: low-density lipoprotein cholesterol.


Instruction: What reacts with nitric oxide to form the powerful oxidant per-oxynitrite?

Output: ant superoxide anion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What reacts with nitric oxide to form the powerful oxidant per-oxynitrite?. ### Response: ant superoxide anion.


Instruction: What contributes to the vasoconstrictor response to angiotensin II and elevates BP?

Output: reduction in nitric oxide bioactivity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What contributes to the vasoconstrictor response to angiotensin II and elevates BP?. ### Response: reduction in nitric oxide bioactivity.


Instruction: What stimulates oxidation of low-density lipoprotein cholesterol and increases expression of monocyte chemoattractant protein-1?

Output: Angiotensin II–induced activa-tion of NAD(P)H oxidase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What stimulates oxidation of low-density lipoprotein cholesterol and increases expression of monocyte chemoattractant protein-1?. ### Response: Angiotensin II–induced activa-tion of NAD(P)H oxidase.


Instruction: What molecule links activation of the RAAS to the atherosclerotic process?

Output: vascular cell adhe-sion molecule-1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What molecule links activation of the RAAS to the atherosclerotic process?. ### Response: vascular cell adhe-sion molecule-1.


Instruction: What do many of the mechanisms that initiate and maintain hyper-tension also damage?

Output: target organs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do many of the mechanisms that initiate and maintain hyper-tension also damage?. ### Response: target organs.


Instruction: Angiotensin II elevates BP and promotes what?

Output: target-organ damage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Angiotensin II elevates BP and promotes what?. ### Response: target-organ damage.


Instruction: What promotes target-organ damage, including atherosclerosis?

Output: Angiotensin II

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What promotes target-organ damage, including atherosclerosis?. ### Response: Angiotensin II.


Instruction: What can mimic or mimic aldosterone?

Output: angiotensin II and norepinephrine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can mimic or mimic aldosterone?. ### Response: angiotensin II and norepinephrine.


Instruction: What can aldosterone mimic or potiate the vasotoxic properties of angiotensin II and norepinephrine?

Output: hormones

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can aldosterone mimic or potiate the vasotoxic properties of angiotensin II and norepinephrine?. ### Response: hormones.


Instruction: What promotes cardiac and vascular smooth muscle cell hypertrophy?

Output: Angiotensin II

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What promotes cardiac and vascular smooth muscle cell hypertrophy?. ### Response: Angiotensin II.


Instruction: How does AT1 receptor activation contribute to endothelial damage and athero-genesis?

Output: by inhibiting the mobilization of endothelial progeni-tor cells from the bone marrow

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does AT1 receptor activation contribute to endothelial damage and athero-genesis?. ### Response: by inhibiting the mobilization of endothelial progeni-tor cells from the bone marrow.


Instruction: What is one of the causes of AT1 activation?

Output: endothelial damage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the causes of AT1 activation?. ### Response: endothelial damage.


Instruction: What was excluded from the study?

Output: failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was excluded from the study?. ### Response: failure.


Instruction: What was the initial SCrlevel?

Output: 1.04 ±0.23 mg/dl

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the initial SCrlevel?. ### Response: 1.04 ±0.23 mg/dl.


Instruction: Most subjects probably had what?

Output: normal kidney function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Most subjects probably had what?. ### Response: normal kidney function.


Instruction: There are clear differences in the causes of CKD when comparing elderly and younger cohorts?

Output: 375

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There are clear differences in the causes of CKD when comparing elderly and younger cohorts?. ### Response: 375.


Instruction: Arteriolar sclerosis, globalglomerulosclerosis and tubular atrophy are more common in what age group?

Output: elderly

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Arteriolar sclerosis, globalglomerulosclerosis and tubular atrophy are more common in what age group?. ### Response: elderly.


Instruction: Arterial artery stenosis and cholesterolembolization are also more common among what age groups?

Output: elderly

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Arterial artery stenosis and cholesterolembolization are also more common among what age groups?. ### Response: elderly.


Instruction: A kidneybiopsy series of 413 patients aged 66 to 79 years showed nephrosclerosis in what percentage of patients?

Output: 34%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A kidneybiopsy series of 413 patients aged 66 to 79 years showed nephrosclerosis in what percentage of patients?. ### Response: 34%.


Instruction: What percentage of patients aged 80 to 89 showed nephrosclerosis in 480 years?

Output: 34%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients aged 80 to 89 showed nephrosclerosis in 480 years?. ### Response: 34%.


Instruction: What was the diagnosis in 17 to 38% of patientscommencing dialysis on three continents?

Output: arterio-pathic disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the diagnosis in 17 to 38% of patientscommencing dialysis on three continents?. ### Response: arterio-pathic disease.


Instruction: On how many continents is nephrosclerosis considered an aspect of aging?

Output: three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On how many continents is nephrosclerosis considered an aspect of aging?. ### Response: three.


Instruction: What is often regarded as a major factor contributing to decline in kidney function?

Output: vasculardisease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is often regarded as a major factor contributing to decline in kidney function?. ### Response: vasculardisease.


Instruction: What may influence the response of theaging kidney to low BP and renin-angiotensin blockade?

Output: vascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may influence the response of theaging kidney to low BP and renin-angiotensin blockade?. ### Response: vascular disease.


Instruction: What are the attendant risks of acute reduction in GFR and hyperkalemia?

Output: low BP and renin–angiotensin blockade

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the attendant risks of acute reduction in GFR and hyperkalemia?. ### Response: low BP and renin–angiotensin blockade.


Instruction: How are most equations used toestimate GFR developed?

Output: youngerpopulations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are most equations used toestimate GFR developed?. ### Response: youngerpopulations.


Instruction: What are often present in the elderly and may influence BP management?

Output: Co-morbidities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are often present in the elderly and may influence BP management?. ### Response: Co-morbidities.


Instruction: Macrovasculardisease is particularly common.

Output: Co-morbidities. Co-morbidities are frequently present inthe elderly and may inﬂuence BP management. Macrovasculardisease is particularly common. This might inﬂuence BPtargets or the preferred agents use to control BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Macrovasculardisease is particularly common.. ### Response: Co-morbidities. Co-morbidities are frequently present inthe elderly and may inﬂuence BP management. Macrovasculardisease is particularly common. This might inﬂuence BPtargets or the preferred agents use to control BP.


Instruction: What might influence the preferred agents use to control BP?

Output: Macrovasculardisease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What might influence the preferred agents use to control BP?. ### Response: Macrovasculardisease.


Instruction: What may be an indication forbeta-blockers or calcium-channel blockers?

Output: angina

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be an indication forbeta-blockers or calcium-channel blockers?. ### Response: angina.


Instruction: Hypotension due to BP-lowering treatmentmay exacerbate the risk of falls and fractures in the elderly?

Output: orthostatic or persistent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hypotension due to BP-lowering treatmentmay exacerbate the risk of falls and fractures in the elderly?. ### Response: orthostatic or persistent.


Instruction: Disease, osteoporosis, or vitamin D deficiency?

Output: cerebrovas-cular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Disease, osteoporosis, or vitamin D deficiency?. ### Response: cerebrovas-cular disease.


Instruction: Drugs and the elderly.

Output: renin– angiotensin-blocking agents such as ACE-Is andARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Drugs and the elderly.. ### Response: renin– angiotensin-blocking agents such as ACE-Is andARBs.


Instruction: The pharmacology and pharmaco-dynamics of BP drugs also change with what?

Output: age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The pharmacology and pharmaco-dynamics of BP drugs also change with what?. ### Response: age.


Instruction: How many strokes were there in 2021?

Output: e364–e467

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes were there in 2021?. ### Response: e364–e467.


Instruction: What was the age-adjusted HR of the Stroke Recovery Programme participants?

Output: 0.11

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the age-adjusted HR of the Stroke Recovery Programme participants?. ### Response: 0.11.


Instruction: How many matched pairs of nonpar-ticipants were there?

Output: n=66

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many matched pairs of nonpar-ticipants were there?. ### Response: n=66.


Instruction: What was the age-adjusted HR for the effect of participant group?

Output: 0.11

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the age-adjusted HR for the effect of participant group?. ### Response: 0.11.


Instruction: What did nonparticipants have a 9 times higher hazard of mortality?

Output: 8446

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did nonparticipants have a 9 times higher hazard of mortality?. ### Response: 8446.


Instruction: What is an important aspect of stroke care?

Output: educating patients with stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an important aspect of stroke care?. ### Response: educating patients with stroke.


Instruction: What does the Cochrane review of inter-ventions for improving modifiable risk factor control in the secondary prevention of stroke identify as lacking?

Output: patient education alone does not lead to improve-ments in modifiable risk factor control or the pre-vention of recurrent cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Cochrane review of inter-ventions for improving modifiable risk factor control in the secondary prevention of stroke identify as lacking?. ### Response: patient education alone does not lead to improve-ments in modifiable risk factor control or the pre-vention of recurrent cardiovascular events.


Instruction: What does STANDFIRM stand for?

Output: Shared Team Approach Between Nurses and Doctors for Improved Risk Factor Management for Stroke Patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does STANDFIRM stand for?. ### Response: Shared Team Approach Between Nurses and Doctors for Improved Risk Factor Management for Stroke Patients.


Instruction: How many people participated in the STANDFiRM trial?

Output: n=76

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people participated in the STANDFiRM trial?. ### Response: n=76.


Instruction: How many stroke patients were in the Management for Stroke Trial?

Output: 563

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many stroke patients were in the Management for Stroke Trial?. ### Response: 563.


Instruction: What did the ExStroke trial show?

Output: repeated encouragement with verbal instruction on being physically active over a 2-year period after stroke was not an effective means of increasing physical activity participation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the ExStroke trial show?. ### Response: repeated encouragement with verbal instruction on being physically active over a 2-year period after stroke was not an effective means of increasing physical activity participation.


Instruction: How long after stroke did repeated encouragement with verbal instruction not have an effect?

Output: 2-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after stroke did repeated encouragement with verbal instruction not have an effect?. ### Response: 2-year.


Instruction: What was not an effective means of increasing physical activity participation?

Output: repeated encouragement with verbal instruction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not an effective means of increasing physical activity participation?. ### Response: repeated encouragement with verbal instruction.


Instruction: What are the current knowledge gaps in this area?

Output: The optimal behavior change

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the current knowledge gaps in this area?. ### Response: The optimal behavior change.


Instruction: The optimal behavior change intervention to reduce recurrent stroke is unknown at present what?

Output: evidence does not support its role in modifying health risk behaviors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The optimal behavior change intervention to reduce recurrent stroke is unknown at present what?. ### Response: evidence does not support its role in modifying health risk behaviors.


Instruction: What is the optimal window to deliver interventions of this nature?

Output: behavior change intervention to reduce recurrent stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the optimal window to deliver interventions of this nature?. ### Response: behavior change intervention to reduce recurrent stroke.


Instruction: Multiple systematic reviews of lifestyle-based behavioral interventions identify an existing knowl-edge gap relating to the potential of the inter-ventions reported to date to affect outcomes of recurrent stroke?

Output: 111

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Multiple systematic reviews of lifestyle-based behavioral interventions identify an existing knowl-edge gap relating to the potential of the inter-ventions reported to date to affect outcomes of recurrent stroke?. ### Response: 111.


Instruction: What do many behavioral interventions fail to identify?

Output: whether a behavior change theory underpinned the intervention deliv-ered

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do many behavioral interventions fail to identify?. ### Response: whether a behavior change theory underpinned the intervention deliv-ered.


Instruction: What makes it difficult to ascertain successful and unsuccessful components of complex behavior change interventions?

Output: Many behavioral interventions in published tri-als after stroke fail to identify whether a behavior change theory underpinned the intervention deliv-ered

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What makes it difficult to ascertain successful and unsuccessful components of complex behavior change interventions?. ### Response: Many behavioral interventions in published tri-als after stroke fail to identify whether a behavior change theory underpinned the intervention deliv-ered.


Instruction: What are the successful and unsuccessful components of complex behavior change interventions?

Output: modifiable risk factor control or the pre-vention of recurrent cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the successful and unsuccessful components of complex behavior change interventions?. ### Response: modifiable risk factor control or the pre-vention of recurrent cardiovascular events.


Instruction: A significant knowledge gap exists with respect to the specific or allied role of family caregivers and dyads in stroke secondary prevention?

Output: promotion and maintenance of health behaviors after stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A significant knowledge gap exists with respect to the specific or allied role of family caregivers and dyads in stroke secondary prevention?. ### Response: promotion and maintenance of health behaviors after stroke.


Instruction: What is needed to address shortfalls after stroke?

Output: future prospective, multi-centered randomized controlled trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed to address shortfalls after stroke?. ### Response: future prospective, multi-centered randomized controlled trials.


Instruction: What are future prospective, multi-centered randomized controlled trials required to address?

Output: shortfalls

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are future prospective, multi-centered randomized controlled trials required to address?. ### Response: shortfalls.


Instruction: A clearly identified behavior change theory as a basis for intervention?

Output: A documented time point after stroke for targeted intervention delivery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A clearly identified behavior change theory as a basis for intervention?. ### Response: A documented time point after stroke for targeted intervention delivery.


Instruction: Who are the Co-Chairs of the KDIGO?

Output: Bertram Kasiske and David Wheeler

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who are the Co-Chairs of the KDIGO?. ### Response: Bertram Kasiske and David Wheeler.


Instruction: Who is the ERT member?

Output: Ashish Upadhyay, Ethan Balk, Amy Earley, Shana Haynes,and Jenny Lamont

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the ERT member?. ### Response: Ashish Upadhyay, Ethan Balk, Amy Earley, Shana Haynes,and Jenny Lamont.


Instruction: What is Shana Haynes' profession?

Output: MD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Shana Haynes' profession?. ### Response: MD.


Instruction: Who contributed significantly to the assessment of the available evidence?

Output: Ashish Upadhyay, Ethan Balk, Amy Earley, Shana Haynes,and Jenny Lamont

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who contributed significantly to the assessment of the available evidence?. ### Response: Ashish Upadhyay, Ethan Balk, Amy Earley, Shana Haynes,and Jenny Lamont.


Instruction: What did the Work Group members do for the entire process of literature review,data extraction and meeting participation?

Output: irexpertise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Work Group members do for the entire process of literature review,data extraction and meeting participation?. ### Response: irexpertise.


Instruction: The critical writing and editing of the statements and rationale made publication of what possible?

Output: this guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The critical writing and editing of the statements and rationale made publication of what possible?. ### Response: this guideline.


Instruction: The generous gift of their time and dedication is greatly appreciated.

Output: Work Group members

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The generous gift of their time and dedication is greatly appreciated.. ### Response: Work Group members.


Instruction: How many externalreviewers assessed the draft guideline?

Output: 268

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many externalreviewers assessed the draft guideline?. ### Response: 268.


Instruction: How many externalreviewers reviewed the draft guideline?

Output: 268

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many externalreviewers reviewed the draft guideline?. ### Response: 268.


Instruction: What did the Work Group consider all of the valuable comments made and incorporate into the final publication?

Output: suggested changes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Work Group consider all of the valuable comments made and incorporate into the final publication?. ### Response: suggested changes.


Instruction: Who was the co-chair of the Working Group?

Output: Christoph Wanner

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the co-chair of the Working Group?. ### Response: Christoph Wanner.


Instruction: How many papers were rated serious limitations?

Output: six

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many papers were rated serious limitations?. ### Response: six.


Instruction: What were the two papers rated as having?

Output: moderate limitations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the two papers rated as having?. ### Response: moderate limitations.


Instruction: How many papers were rated as moderate limitations?

Output: Two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many papers were rated as moderate limitations?. ### Response: Two.


Instruction: Why were the aims, methodology and findings poorly discu ssed?

Output: there was little description of the participants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why were the aims, methodology and findings poorly discu ssed?. ### Response: there was little description of the participants.


Instruction: What was one paper rated as minor limitations?

Output: Coherence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was one paper rated as minor limitations?. ### Response: Coherence.


Instruction: What was rated minor concerns overall?

Output: Relevance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was rated minor concerns overall?. ### Response: Relevance.


Instruction: Did clinicians see a problem and think it can be improved?

Output: clinicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Did clinicians see a problem and think it can be improved?. ### Response: clinicians.


Instruction: How many different improvements were suggested?

Output: six

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many different improvements were suggested?. ### Response: six.


Instruction: What was it impossible to conclude in favour of from the data?

Output: any particular intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was it impossible to conclude in favour of from the data?. ### Response: any particular intervention.


Instruction: What was the relevance of the sub-finding to the focus of the review high?

Output: these models may have the potential to improve patient experience at transitions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the relevance of the sub-finding to the focus of the review high?. ### Response: these models may have the potential to improve patient experience at transitions.


Instruction: How many studies were from the UK?

Output: All but one

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were from the UK?. ### Response: All but one.


Instruction: What was rated as moderate concerns?

Output: Adequacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was rated as moderate concerns?. ### Response: Adequacy.


Instruction: Where was the sub-finding found?

Output: in a number of studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where was the sub-finding found?. ### Response: in a number of studies.


Instruction: What were the concerns about the sub-finding?

Output: there was inadequate depth

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the concerns about the sub-finding?. ### Response: there was inadequate depth.


Instruction: What was the overall assessment of confidence?

Output: low

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the overall assessment of confidence?. ### Response: low.


Instruction: How many increments did the confidence assessment receive?

Output: two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many increments did the confidence assessment receive?. ### Response: two.


Instruction: How many increments were there in the Communication Review sub-finding 3a?

Output: two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many increments were there in the Communication Review sub-finding 3a?. ### Response: two.


Instruction: People with heart failure, their informal carers and professionals felt that there was poor communication between services?

Output: liaison between the hospital and the doctors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: People with heart failure, their informal carers and professionals felt that there was poor communication between services?. ### Response: liaison between the hospital and the doctors.


Instruction: Professionals within and outside HF services felt that there was poor communication across boundaries?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Professionals within and outside HF services felt that there was poor communication across boundaries?. ### Response: 3.


Instruction: Inadequate and delayed transfer of information led to what?

Output: burden on patients and waste of resources

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Inadequate and delayed transfer of information led to what?. ### Response: burden on patients and waste of resources.


Instruction: In some areas, management plans were not shared with the prescriber, what did it contribute to?

Output: lack of / under -treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In some areas, management plans were not shared with the prescriber, what did it contribute to?. ### Response: lack of / under -treatment.


Instruction: One patient explained how there were times when there was a bit of a lack of what?

Output: communication

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: One patient explained how there were times when there was a bit of a lack of what?. ### Response: communication.


Instruction: What would my doctor say to me when I told him I was on such and such?

Output: ‘I’ve not had any word about that’

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would my doctor say to me when I told him I was on such and such?. ### Response: ‘I’ve not had any word about that’.


Instruction: What is part of the problem with a printed prescription?

Output: lack of communication

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is part of the problem with a printed prescription?. ### Response: lack of communication.


Instruction: How many studies were based on this sub-finding?

Output: six

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were based on this sub-finding?. ### Response: six.


Instruction: What was the liaison between the hospital and the doctors?

Output: 4.5mg of Bisoprolol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the liaison between the hospital and the doctors?. ### Response: 4.5mg of Bisoprolol.


Instruction: How many studies were included in the sub-finding?

Output: six

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were included in the sub-finding?. ### Response: six.


Instruction: How many journal articles has Professor Rodrigues published?

Output: more than 40

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many journal articles has Professor Rodrigues published?. ### Response: more than 40.


Instruction: How many book chapters has Professor Rodriguez contributed in the field ofnephrology and hypertension?

Output: 15

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many book chapters has Professor Rodriguez contributed in the field ofnephrology and hypertension?. ### Response: 15.


Instruction: Who is a reviewer for many scientific journals and an anadvisory committee member to various organizations?

Output: Professor Rodrigues

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a reviewer for many scientific journals and an anadvisory committee member to various organizations?. ### Response: Professor Rodrigues.


Instruction: Who reported no relevant financial relationships?

Output: Dr Rodrigues

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who reported no relevant financial relationships?. ### Response: Dr Rodrigues.


Instruction: Where is Mark J Sarnak Professor of Medicine?

Output: TuftsUniversity of School of Medicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Mark J Sarnak Professor of Medicine?. ### Response: TuftsUniversity of School of Medicine.


Instruction: What is the division of Nephrology at Tufts Medical Center?

Output: Director of Research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the division of Nephrology at Tufts Medical Center?. ### Response: Director of Research.


Instruction: Where did he obtain his medical degree?

Output: Columbia University College of Physicians and Surgeons

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where did he obtain his medical degree?. ### Response: Columbia University College of Physicians and Surgeons.


Instruction: What is he currently researching?

Output: diabetes mellitus(including diabetic nephropathy, diabetic retinopathy, insulinresistance, CVD, hemostasis, immunotherapy of type 1 diabetes,gestational diabetes), hypertension and morbid obesity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is he currently researching?. ### Response: diabetes mellitus(including diabetic nephropathy, diabetic retinopathy, insulinresistance, CVD, hemostasis, immunotherapy of type 1 diabetes,gestational diabetes), hypertension and morbid obesity.


Instruction: How many publications has Dr Sarnak authored?

Output: more than 175

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many publications has Dr Sarnak authored?. ### Response: more than 175.


Instruction: How many journals does he peer review?

Output: more than a dozen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many journals does he peer review?. ### Response: more than a dozen.


Instruction: How many journals did he edit between 2006 and 2007?

Output: more than a dozen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many journals did he edit between 2006 and 2007?. ### Response: more than a dozen.


Instruction: How many honors has he received in 2008?

Output: Best Teacher Award for theMedical Residents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many honors has he received in 2008?. ### Response: Best Teacher Award for theMedical Residents.


Instruction: In what year did Professor Schernthaner become Professor of Medicine at the University of Vienna, Austria?

Output: 1987

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did Professor Schernthaner become Professor of Medicine at the University of Vienna, Austria?. ### Response: 1987.


Instruction: What award was given to the Medical Clerkship in 2009?

Output: Excellence in Teaching

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What award was given to the Medical Clerkship in 2009?. ### Response: Excellence in Teaching.


Instruction: In what magazine did Dr Sarnak receive an award for teaching excellence?

Output: Boston Magazine Best Doctors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what magazine did Dr Sarnak receive an award for teaching excellence?. ### Response: Boston Magazine Best Doctors.


Instruction: In what year did ProfessorSchernthaner become Head of the Department of Medicine I at the Rudolfstiftung Hospital in Vienna?

Output: 1988

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did ProfessorSchernthaner become Head of the Department of Medicine I at the Rudolfstiftung Hospital in Vienna?. ### Response: 1988.


Instruction: Between 1982 and 1988, what was he the Head of Division of Metabolism &Endocrinology at the University of Vienna in regards to diabetes mellitus?

Output: ProfessorSchernthaner

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Between 1982 and 1988, what was he the Head of Division of Metabolism &Endocrinology at the University of Vienna in regards to diabetes mellitus?. ### Response: ProfessorSchernthaner.


Instruction: What type of diabetes is Schernthaner a member of?

Output: gestational diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diabetes is Schernthaner a member of?. ### Response: gestational diabetes.


Instruction: What is the name of the Austrian Diabetes Association President?

Output: Professor Schernthaner

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Austrian Diabetes Association President?. ### Response: Professor Schernthaner.


Instruction: Who was the President of the first Joint Congress of the German and Austrian Diabetes Associations?

Output: Professor Schernthaner

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the President of the first Joint Congress of the German and Austrian Diabetes Associations?. ### Response: Professor Schernthaner.


Instruction: How many publications has Prof. Schernthanerauthored in peer-reviewed journals?

Output: 350

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many publications has Prof. Schernthanerauthored in peer-reviewed journals?. ### Response: 350.


Instruction: How many times have his papers been cited?

Output: 8300

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many times have his papers been cited?. ### Response: 8300.


Instruction: What is the Hirsch index of Web of Science?

Output: 43

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Hirsch index of Web of Science?. ### Response: 43.


Instruction: What is the score for long-term risk classification in individuals with type 2 diabetes and metabolic syndrome from the Multi-Ethnic Study of Atherosclerosis?

Output: Coronary artery calcium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the score for long-term risk classification in individuals with type 2 diabetes and metabolic syndrome from the Multi-Ethnic Study of Atherosclerosis?. ### Response: Coronary artery calcium.


Instruction: What was the JAMA Cardiol. 2017;2:1332-40?

Output: Coronary artery calcium score for long-term risk classification in individuals with type 2 diabetes and metabolic syndrome from the Multi-Ethnic Study of Atherosclerosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the JAMA Cardiol. 2017;2:1332-40?. ### Response: Coronary artery calcium score for long-term risk classification in individuals with type 2 diabetes and metabolic syndrome from the Multi-Ethnic Study of Atherosclerosis.


Instruction: What is the phenotype of severe hypercholesterolemia?

Output: clinical diagnosis, management, and emerging thera-pies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the phenotype of severe hypercholesterolemia?. ### Response: clinical diagnosis, management, and emerging thera-pies.


Instruction: What is a meta-analysis of low-density lipoprotein cholesterol and apolipoprotein B as markers of cardiovascular risk?

Output: Sniderman

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a meta-analysis of low-density lipoprotein cholesterol and apolipoprotein B as markers of cardiovascular risk?. ### Response: Sniderman.


Instruction: What is the association of coronary artery calcium with atherosclerotic cardiovascular disease events?

Output: Ten-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association of coronary artery calcium with atherosclerotic cardiovascular disease events?. ### Response: Ten-year.


Instruction: What year did the Multi-Ethnic Study of Atherosclerosis begin?

Output: 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did the Multi-Ethnic Study of Atherosclerosis begin?. ### Response: 2018.


Instruction: What did Mihaylova B, Emberson J, Blackwell L, et al. do?

Output: lowering LDL cholesterol with statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Mihaylova B, Emberson J, Blackwell L, et al. do?. ### Response: lowering LDL cholesterol with statin therapy.


Instruction: What did lowering LDL cholesterol with statin therapy do for people at low risk of vascular disease?

Output: The effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did lowering LDL cholesterol with statin therapy do for people at low risk of vascular disease?. ### Response: The effects.


Instruction: When did the Lancet publish a meta-analysis of data from 27 randomised trials?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Lancet publish a meta-analysis of data from 27 randomised trials?. ### Response: 2012.


Instruction: What is pravastatin used for in Japan?

Output: Primary prevention of cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is pravastatin used for in Japan?. ### Response: Primary prevention of cardiovascular disease.


Instruction: What is the MEGA Study?

Output: a prospective randomised controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the MEGA Study?. ### Response: a prospective randomised controlled trial.


Instruction: How many people were enrolled in the 2013 ACC/AHA guideline?

Output: 27

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were enrolled in the 2013 ACC/AHA guideline?. ### Response: 27.


Instruction: What does blood cholesterol do to reduce ath-erosclerotic cardiovascular risk in adults?

Output: treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does blood cholesterol do to reduce ath-erosclerotic cardiovascular risk in adults?. ### Response: treatment.


Instruction: What does the American College of Cardiology/American Heart Association Task Force on Practice Guidelines do?

Output: reduce ath-erosclerotic cardiovascular risk in adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the American College of Cardiology/American Heart Association Task Force on Practice Guidelines do?. ### Response: reduce ath-erosclerotic cardiovascular risk in adults.


Instruction: What is effective communication for for cardiovascular disease prevention?

Output: What to say and how to say it

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is effective communication for for cardiovascular disease prevention?. ### Response: What to say and how to say it.


Instruction: What is a benefit model for prevention of cardiovascular disease: an opportunity to harmonize guidelines?

Output: High-intensity statins: guideline expectations and clinical application. JAMA. 2017;317:2543–4. S4.4.2-29. Thanassoulis G, Pencina MJ, Sniderman AD. The benefit model for prevention of cardiovascular disease: an opportunity to harmonize guidelines. JAMA Cardiol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a benefit model for prevention of cardiovascular disease: an opportunity to harmonize guidelines?. ### Response: High-intensity statins: guideline expectations and clinical application. JAMA. 2017;317:2543–4. S4.4.2-29. Thanassoulis G, Pencina MJ, Sniderman AD. The benefit model for prevention of cardiovascular disease: an opportunity to harmonize guidelines. JAMA Cardiol.


Instruction: What is important in deciding who should receive statin treatment?

Output: Cholesterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is important in deciding who should receive statin treatment?. ### Response: Cholesterol.


Instruction: When did Cholesterol, not just cardio-vascular risk, be important?

Output: in deciding who should receive statin treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Cholesterol, not just cardio-vascular risk, be important?. ### Response: in deciding who should receive statin treatment.


Instruction: What was the name of the study that examined the incidence of cardiovascular disease in individuals with psoriasis?

Output: systematic review and meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the study that examined the incidence of cardiovascular disease in individuals with psoriasis?. ### Response: systematic review and meta-analysis.