Instruction: Current standards for cardiac catheterization labo-ratories include what?

Output: •Specific procedures and policies are in place to minimize patient (and operator) risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Current standards for cardiac catheterization labo-ratories include what?. ### Response: •Specific procedures and policies are in place to minimize patient (and operator) risk.


Instruction: Who coordinates all radiation safety procedures?

Output: A radiation safety officer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who coordinates all radiation safety procedures?. ### Response: A radiation safety officer.


Instruction: Who coordinates all radiation safetyissues and works conjointly with the medical or healthphysicist?

Output: A radiation safety officer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who coordinates all radiation safetyissues and works conjointly with the medical or healthphysicist?. ### Response: A radiation safety officer.


Instruction: What is reduced to as low a level asreasonably can be achieved?

Output: Patient radiation exposure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reduced to as low a level asreasonably can be achieved?. ### Response: Patient radiation exposure.


Instruction: Who identify patients at increased risk for high procedural radiation exposure?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who identify patients at increased risk for high procedural radiation exposure?. ### Response: •.


Instruction: What includes radiation safety informa tion?

Output: Informed consent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What includes radiation safety informa tion?. ### Response: Informed consent.


Instruction: What is essential to the safe practice of radiation dose management?

Output: A basic primer on the physics of x-ray imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is essential to the safe practice of radiation dose management?. ### Response: A basic primer on the physics of x-ray imaging.


Instruction: What are now well recognized as potentially serious complications of prolongedinterventional procedures?

Output: Adverse radiation effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are now well recognized as potentially serious complications of prolongedinterventional procedures?. ### Response: Adverse radiation effects.


Instruction: What does not in-clude cine acquisition imaging and is therefore not an accurate measure of patient radiation dose?

Output: Fluoroscopic time

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not in-clude cine acquisition imaging and is therefore not an accurate measure of patient radiation dose?. ### Response: Fluoroscopic time.


Instruction: In what year were the interventional reference point and air kermaarea product required to be reported oninterventional x-ray systems?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year were the interventional reference point and air kermaarea product required to be reported oninterventional x-ray systems?. ### Response: 2006.


Instruction: What are useful in assessment of potential tissue adverse effects?

Output: Total air kerma atthe interventional reference point (Ka,r,in Gy) and air kermaarea product (PKA, in Gycm2) are required to be reported oninterventional x-ray systems

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are useful in assessment of potential tissue adverse effects?. ### Response: Total air kerma atthe interventional reference point (Ka,r,in Gy) and air kermaarea product (PKA, in Gycm2) are required to be reported oninterventional x-ray systems.


Instruction: What should be included in the catheterization record at the conclusion of each procedure?

Output: tissue adverse effects or long-termradiation sequelae

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be included in the catheterization record at the conclusion of each procedure?. ### Response: tissue adverse effects or long-termradiation sequelae.


Instruction: What summarizes considerations forpatient follow-up based on radiation dose during theprocedure?

Output: Appendix 4D

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What summarizes considerations forpatient follow-up based on radiation dose during theprocedure?. ### Response: Appendix 4D.


Instruction: Patients should be assessed for risk of what before PCI?

Output: contrast-induced AKI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients should be assessed for risk of what before PCI?. ### Response: contrast-induced AKI.


Instruction: What should patients undergoing cardiac catheterization receive?

Output: adequate preparatoryhydration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients undergoing cardiac catheterization receive?. ### Response: adequate preparatoryhydration.


Instruction: What should beminimized in patients with CKD?

Output: the volume of contrast media

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should beminimized in patients with CKD?. ### Response: the volume of contrast media.


Instruction: How much creatinine clearance is 60mL/min?

Output: <60mL/min

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much creatinine clearance is 60mL/min?. ### Response: <60mL/min.


Instruction: What isn't useful for the prevention of contrast-induced AKI?

Output: Administration of N-acetyl-L-cysteine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What isn't useful for the prevention of contrast-induced AKI?. ### Response: Administration of N-acetyl-L-cysteine.


Instruction: What is one of the most common causes of contrast nephropathy?

Output: Contrast-induced AKI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the most common causes of contrast nephropathy?. ### Response: Contrast-induced AKI.


Instruction: What reduces the risk of death in survivors of MI?

Output: Cardiac rehabilitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What reduces the risk of death in survivors of MI?. ### Response: Cardiac rehabilitation.


Instruction: How long after CABG are exercise and educa-tion sessions associated with mortality?

Output: 4 to 8 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after CABG are exercise and educa-tion sessions associated with mortality?. ### Response: 4 to 8 weeks.


Instruction: How many times-weekly educa-tion and exercise sessions are associated with aHillis et al 2011 ACCF/AHA CABG Guideline e683Downloaded from http://ahajournals.org by on April 26, 2023?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many times-weekly educa-tion and exercise sessions are associated with aHillis et al 2011 ACCF/AHA CABG Guideline e683Downloaded from http://ahajournals.org by on April 26, 2023?. ### Response: 3.


Instruction: What does the ASH guideline panel suggest for treatment of VTE?

Output: using an INRrecall interval of 4 weeks or fewer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the ASH guideline panel suggest for treatment of VTE?. ### Response: using an INRrecall interval of 4 weeks or fewer.


Instruction: How long is the recommended INR interval?

Output: 4 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the recommended INR interval?. ### Response: 4 weeks.


Instruction: When was this article published?

Output: 21 April 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this article published?. ### Response: 21 April 2023.


Instruction: What is a common cause of myocardial infarction?

Output: coronary revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a common cause of myocardial infarction?. ### Response: coronary revascularization.


Instruction: What is the role of monitoring changes in cardiac troponin I assay results for?

Output: early diagnosis of myo-cardial infarction and prediction of risk of adverse events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of monitoring changes in cardiac troponin I assay results for?. ### Response: early diagnosis of myo-cardial infarction and prediction of risk of adverse events.


Instruction: What is the importance of the proper gold standard?

Output: Using high- sensitivity tro-ponin T

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the importance of the proper gold standard?. ### Response: Using high- sensitivity tro-ponin T.


Instruction: What are the percentiles of Troponin T from a random population sample?

Output: 149

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the percentiles of Troponin T from a random population sample?. ### Response: 149.


Instruction: When was the Stat Heart Program published?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Stat Heart Program published?. ### Response: 2008.


Instruction: Where was the text downloaded?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where was the text downloaded?. ### Response: http://ahajournals.org.


Instruction: What was the title of the paper?

Output: Stat Heart Program

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the title of the paper?. ### Response: Stat Heart Program.


Instruction: What is the leading cause of death for people of most racial/ethnic groups in the US?

Output: S1-1–S1-3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the leading cause of death for people of most racial/ethnic groups in the US?. ### Response: S1-1–S1-3.


Instruction: How much money is estimated to be spent annually on healthcare services, medications, and lost productivity?

Output: >$200 billion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much money is estimated to be spent annually on healthcare services, medications, and lost productivity?. ### Response: >$200 billion.


Instruction: What is at-tributable to suboptimal implementation of preven-tion strategies and uncontrolled ASCVD risk factors?

Output: S1-1–S1-3 In the United States, it is also the leading cause of death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is at-tributable to suboptimal implementation of preven-tion strategies and uncontrolled ASCVD risk factors?. ### Response: S1-1–S1-3 In the United States, it is also the leading cause of death.


Instruction: What is the term for a myocardial infarc-tion?

Output: MI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for a myocardial infarc-tion?. ### Response: MI.


Instruction: How many cardiovas-cular risk factors did most Americans have before their ASCVD event?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many cardiovas-cular risk factors did most Americans have before their ASCVD event?. ### Response: 1.


Instruction: In 2010, what was the AHA's definition of "ideal cardiovascular health"?

Output: Life’s Simple 7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In 2010, what was the AHA's definition of "ideal cardiovascular health"?. ### Response: Life’s Simple 7.


Instruction: What is a new model of ideal cardiovascular health called?

Output: Life’s Simple 7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a new model of ideal cardiovascular health called?. ### Response: Life’s Simple 7.


Instruction: What is the 2018 Journal of American College of Cardiol-ogy (JACC) Cardiovascular Health Promotion Series?

Output: Clinicians will find the 2018 Journal of American College of Cardiol-ogy (JACC) Cardiovascular Health Promotion Series very helpful in approaching the various aspects of preven-tion with patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2018 Journal of American College of Cardiol-ogy (JACC) Cardiovascular Health Promotion Series?. ### Response: Clinicians will find the 2018 Journal of American College of Cardiol-ogy (JACC) Cardiovascular Health Promotion Series very helpful in approaching the various aspects of preven-tion with patients.


Instruction: What has been associated with a lower prevalence and incidence of ASCVD events, heart failure, atrial fibrillation, cancer, depression and cognitive impairment?

Output: ideal cardiovascular health factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been associated with a lower prevalence and incidence of ASCVD events, heart failure, atrial fibrillation, cancer, depression and cognitive impairment?. ### Response: ideal cardiovascular health factors.


Instruction: What is critically important for prevention of many important health conditions?

Output: moving individuals toward ideal cardiovascular health

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is critically important for prevention of many important health conditions?. ### Response: moving individuals toward ideal cardiovascular health.


Instruction: The ACC/AHA Task Force on Clinical Practice Guide-lines has commissioned a guideline to consolidate what?

Output: existing recommendations and various recent scientific statements, expert consensus documents, and clinical practice guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The ACC/AHA Task Force on Clinical Practice Guide-lines has commissioned a guideline to consolidate what?. ### Response: existing recommendations and various recent scientific statements, expert consensus documents, and clinical practice guidelines.


Instruction: What is the primary prevention of ASCVD?

Output: promote a healthy lifestyle

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary prevention of ASCVD?. ### Response: promote a healthy lifestyle.


Instruction: What are new recom-mendations for aspirin use, exercise and physical activ-ity, and tobacco use?

Output: recommendations related to team-based care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are new recom-mendations for aspirin use, exercise and physical activ-ity, and tobacco use?. ### Response: recommendations related to team-based care.


Instruction: To create a comprehensive yet targeted ACC/AHA guideline on the prevention of asCVD, what is the goal of the guideline?

Output: to consolidate existing recommendations and various recent scientific statements, expert consensus documents, and clinical practice guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: To create a comprehensive yet targeted ACC/AHA guideline on the prevention of asCVD, what is the goal of the guideline?. ### Response: to consolidate existing recommendations and various recent scientific statements, expert consensus documents, and clinical practice guidelines.


Instruction: What is the purpose of the ACC/AHA guideline?

Output: to consolidate existing recommendations and various recent scientific statements, expert consensus documents, and clinical practice guidelines into a single guidance document fo-cused on the primary prevention of ASCVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of the ACC/AHA guideline?. ### Response: to consolidate existing recommendations and various recent scientific statements, expert consensus documents, and clinical practice guidelines into a single guidance document fo-cused on the primary prevention of ASCVD.


Instruction: What format has the guideline been formatted in?

Output: modular chunk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What format has the guideline been formatted in?. ### Response: modular chunk.


Instruction: Where do prevention strategies occur?

Output: at the population level

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where do prevention strategies occur?. ### Response: at the population level.


Instruction: Who must engage with prevention strategies?

Output: individual adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who must engage with prevention strategies?. ### Response: individual adults.


Instruction: How can adults slow the de-velopment of ASCVD?

Output: engage individual adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can adults slow the de-velopment of ASCVD?. ### Response: engage individual adults.


Instruction: What is the most important way to pre-vent asscvd?

Output: to promote a healthy lifestyle through-out life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most important way to pre-vent asscvd?. ### Response: to promote a healthy lifestyle through-out life.


Instruction: How must prevention strategies include a strong focus on lifestyle optimization?

Output: to minimize the risk of future ASCVD events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How must prevention strategies include a strong focus on lifestyle optimization?. ### Response: to minimize the risk of future ASCVD events.


Instruction: Tobacco use and ex-posure to secondhand smoke) to minimize the risk of future ASCVD events?

Output: Prevention strategies must include a strong focus on lifestyle optimization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Tobacco use and ex-posure to secondhand smoke) to minimize the risk of future ASCVD events?. ### Response: Prevention strategies must include a strong focus on lifestyle optimization.


Instruction: What is the first step in deciding where there may be a need for pharmacotherapy?

Output: A comprehensive patient-centered approach

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the first step in deciding where there may be a need for pharmacotherapy?. ### Response: A comprehensive patient-centered approach.


Instruction: A comprehensive patient-centered approach addresses all aspects of what?

Output: preven-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A comprehensive patient-centered approach addresses all aspects of what?. ### Response: preven-tion.


Instruction: What should be emphasized on a regular basis?

Output: lifestyle goals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be emphasized on a regular basis?. ### Response: lifestyle goals.


Instruction: When should medications to reduce ASCVD risk be considered?

Output: when a person’s risk is sufficiently high

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When should medications to reduce ASCVD risk be considered?. ### Response: when a person’s risk is sufficiently high.


Instruction: What should medications to reduce ASCVD risk be considered as part of?

Output: shared

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should medications to reduce ASCVD risk be considered as part of?. ### Response: shared.


Instruction: No RCTs of IV alteplase in AIS with baseline MRI to identify CMBs have been conducted to identify what?

Output: no determination of the effect of baseline CMB on the treatment effect of alteplase with CMB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No RCTs of IV alteplase in AIS with baseline MRI to identify CMBs have been conducted to identify what?. ### Response: no determination of the effect of baseline CMB on the treatment effect of alteplase with CMB.


Instruction: No determination of the effect of baseline CMB on the treatment effect is available what is there no direct evidence of?

Output: IV alteplase provides no benefit or produces harm in eligible patients with CMBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No determination of the effect of baseline CMB on the treatment effect is available what is there no direct evidence of?. ### Response: IV alteplase provides no benefit or produces harm in eligible patients with CMBs.


Instruction: What does IV alteplase provide in patients with CMBs?

Output: no benefit or produces harm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does IV alteplase provide in patients with CMBs?. ### Response: no benefit or produces harm.


Instruction: What could lead to the exclusion of patients who would benefit from treatment?

Output: withholding treatment on the basis of the presence of CMBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could lead to the exclusion of patients who would benefit from treatment?. ### Response: withholding treatment on the basis of the presence of CMBs.


Instruction: What is the name of the online supplement?

Output: Data Supplement 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the online supplement?. ### Response: Data Supplement 1.


Instruction: When was Data Supplement 1 downloaded?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Data Supplement 1 downloaded?. ### Response: April 28, 2023.


Instruction: What can remove bivalirudin or argatroban?

Output: e36S Parenteral Anticoagulants Hemodialysis or hemoperfusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can remove bivalirudin or argatroban?. ### Response: e36S Parenteral Anticoagulants Hemodialysis or hemoperfusion.


Instruction: What can clear hirudin using high-flux dialysis membranes?

Output: Dialysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can clear hirudin using high-flux dialysis membranes?. ### Response: Dialysis.


Instruction: Who oversaw the development of this article?

Output: Dr Garcia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who oversaw the development of this article?. ### Response: Dr Garcia.


Instruction: Dr Garcia contributed as a Topic Editor. Dr Baglin contributed as what?

Output: panelist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Dr Garcia contributed as a Topic Editor. Dr Baglin contributed as what?. ### Response: panelist.


Instruction: Dr Weitz contributed as who?

Output: panelist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Dr Weitz contributed as who?. ### Response: panelist.


Instruction: What did Dr Samama contribute?

Output: as a panelist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Dr Samama contribute?. ### Response: as a panelist.


Instruction: Who contributed as a panelist?

Output: Dr Samama

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who contributed as a panelist?. ### Response: Dr Samama.


Instruction: Who reported to CHEST the following confli cts of interest?

Output: the authors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who reported to CHEST the following confli cts of interest?. ### Response: the authors.


Instruction: Who has received honoraria for lectures or consulting from Bayer Healthcare, Johnson & Johnson, Bristol-Myers Squibb, and sanofi-aventis?

Output: Dr Samama

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who has received honoraria for lectures or consulting from Bayer Healthcare, Johnson & Johnson, Bristol-Myers Squibb, and sanofi-aventis?. ### Response: Dr Samama.


Instruction: Who has served on a steering committee for Daiichi-Sankyo?

Output: Boehringer Ingelheim

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who has served on a steering committee for Daiichi-Sankyo?. ### Response: Boehringer Ingelheim.


Instruction: Who was on a steering committee for Daiichi-Sankyo?

Output: Dr Samama

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was on a steering committee for Daiichi-Sankyo?. ### Response: Dr Samama.


Instruction: Who reported that no potential confl icts of interest exist with any companies/organizations whose products or services may be dis-cussed in this article?

Output: Dr Baglin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who reported that no potential confl icts of interest exist with any companies/organizations whose products or services may be dis-cussed in this article?. ### Response: Dr Baglin.


Instruction: Who played no role in the development of the guidelines?

Output: The sponsors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who played no role in the development of the guidelines?. ### Response: The sponsors.


Instruction: Sponsoring organizations are not allowed what?

Output: prepublication access

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Sponsoring organizations are not allowed what?. ### Response: prepublication access.


Instruction: Who are blinded to the funding sources?

Output: the chair, and members of the Health & Science Policy Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who are blinded to the funding sources?. ### Response: the chair, and members of the Health & Science Policy Committee.


Instruction: Where are further details on the Confl ict of Interest Policy available?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are further details on the Confl ict of Interest Policy available?. ### Response: http://chestnet.org.


Instruction: Who endorses this guideline?

Output: American Association for Clinical Chemistry, the American College of Clin-ical Pharmacy, the American Society of Health-System Pharma-cists, the American Society of Hematology, and the International Society of Thrombosis and Hematosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who endorses this guideline?. ### Response: American Association for Clinical Chemistry, the American College of Clin-ical Pharmacy, the American Society of Health-System Pharma-cists, the American Society of Hematology, and the International Society of Thrombosis and Hematosis.


Instruction: The American College of Clin-ical Pharmacy, the American Society of Health-System Pharma-cists, and the International Society of Thrombosis and Hematosis are examples of what?

Output: This guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The American College of Clin-ical Pharmacy, the American Society of Health-System Pharma-cists, and the International Society of Thrombosis and Hematosis are examples of what?. ### Response: This guideline.


Instruction: What is the thromboplastic action of cephalin?

Output: inhibition of blood clotting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the thromboplastic action of cephalin?. ### Response: inhibition of blood clotting.


Instruction: When was the Am J Physiol. 41 : 250-257?

Output: 1916

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Am J Physiol. 41 : 250-257?. ### Response: 1916.


Instruction: What does heparin prevent the conversion of into thrombin?

Output: pro-thrombin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does heparin prevent the conversion of into thrombin?. ### Response: pro-thrombin.


Instruction: What is the name of the unidentifiable substance that acts in conjunction with hisparin to prevent?

Output: inhibition of blood clotting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the unidentifiable substance that acts in conjunction with hisparin to prevent?. ### Response: inhibition of blood clotting.


Instruction: When was the Am J Physiol published?

Output: 1916

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Am J Physiol published?. ### Response: 1916.


Instruction: What year was J Physiol published?

Output: 1916

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was J Physiol published?. ### Response: 1916.


Instruction: What was the name of the journal in 1939?

Output: Am J Physiol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the journal in 1939?. ### Response: Am J Physiol.


Instruction: How was antithrombin 3 prepared?

Output: disc electrophoresis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was antithrombin 3 prepared?. ### Response: disc electrophoresis.


Instruction: By what method was electrophoresis performed?

Output: disc

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: By what method was electrophoresis performed?. ### Response: disc.


Instruction: What was the total number of disc electrophoretics performed in 1968?

Output: 89 - 91

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the total number of disc electrophoretics performed in 1968?. ### Response: 89 - 91.


Instruction: In what year was Scand J Clin Lab Invest published?

Output: 1968

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was Scand J Clin Lab Invest published?. ### Response: 1968.


Instruction: What is the structure of the antithrombin-binding site in hep-arin?

Output: Structure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the structure of the antithrombin-binding site in hep-arin?. ### Response: Structure.


Instruction: When did Proc Natl Acad Sci U S A publish?

Output: 1979

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Proc Natl Acad Sci U S A publish?. ### Response: 1979.


Instruction: What year was Acad Sci U S A published?

Output: 1979

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was Acad Sci U S A published?. ### Response: 1979.


Instruction: How many publications were published in 1979?

Output: 7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many publications were published in 1979?. ### Response: 7.


Instruction: What is the name of the journal that published 76 ( 7 ): 3198-3202?

Output: Proc Natl Acad Sci U S A

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that published 76 ( 7 ): 3198-3202?. ### Response: Proc Natl Acad Sci U S A.


Instruction: What mechanism is activated in unstable angina and myocar-dial infarction?

Output: coagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What mechanism is activated in unstable angina and myocar-dial infarction?. ### Response: coagulation.


Instruction: When was the Circulation. 90 ( 1 ): 61-68?

Output: 1994

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circulation. 90 ( 1 ): 61-68?. ### Response: 1994.


Instruction: What is the name of the organization that represents the American Heart Association Stroke Council?

Output: Council on Cardiovascular and Stroke Nursing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that represents the American Heart Association Stroke Council?. ### Response: Council on Cardiovascular and Stroke Nursing.


Instruction: What are the names of the organizations that represent the American heart association?

Output: Stroke Council; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; and Council on Quality of Care and Outcomes Research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the organizations that represent the American heart association?. ### Response: Stroke Council; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; and Council on Quality of Care and Outcomes Research.


Instruction: Who is a member of the Council on Clinical Cardiology?

Output: Yaghi S, Willey JZ, Cucchiara B, Goldstein JN, Gonzales NR, Khatri P, Kim LJ, Mayer SA, Sheth KN, Schwamm LH; on behalf of the American Heart Association Stroke Council

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a member of the Council on Clinical Cardiology?. ### Response: Yaghi S, Willey JZ, Cucchiara B, Goldstein JN, Gonzales NR, Khatri P, Kim LJ, Mayer SA, Sheth KN, Schwamm LH; on behalf of the American Heart Association Stroke Council.


Instruction: What is a sci-entific statement for healthcare professionals from the American Heart Association/American Stroke Association?

Output: Treatment and outcome of hemorrhagic transformation after intravenous alteplase in acute ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a sci-entific statement for healthcare professionals from the American Heart Association/American Stroke Association?. ### Response: Treatment and outcome of hemorrhagic transformation after intravenous alteplase in acute ischemic stroke.


Instruction: What is an example of hemorrhagic transformation after intravenous alteplase in acute ischemic stroke?

Output: Treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of hemorrhagic transformation after intravenous alteplase in acute ischemic stroke?. ### Response: Treatment.


Instruction: What is the 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, and management of high blood pressure in adults?

Output: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, and management of high blood pressure in adults?. ### Response: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.


Instruction: What did the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines do?

Output: prevention, detection, eval-uation, and management of high blood pressure in adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines do?. ### Response: prevention, detection, eval-uation, and management of high blood pressure in adults.


Instruction: When was the corrected version of the report published?

Output: 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the corrected version of the report published?. ### Response: 2018.


Instruction: What is the name of the task force on clinical practice guidelines?

Output: American College of Cardiology/American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the task force on clinical practice guidelines?. ### Response: American College of Cardiology/American Heart Association.


Instruction: What did UFH have a sixfold greater effect than?

Output: LMWH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did UFH have a sixfold greater effect than?. ### Response: LMWH.


Instruction: What did other investigators report that LMWH causes?

Output: signiﬁ  cant inhibition of osteoblast growth

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did other investigators report that LMWH causes?. ### Response: signiﬁ  cant inhibition of osteoblast growth.


Instruction: How did the anticoagu-lants effect bone nodule formation?

Output: inhibited

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did the anticoagu-lants effect bone nodule formation?. ### Response: inhibited.


Instruction: How many studies have reported the effects of LMWH on bone density?

Output: Three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies have reported the effects of LMWH on bone density?. ### Response: Three.


Instruction: What causes signifi cant inhibition of osteoblast growth?

Output: LMWH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes signifi cant inhibition of osteoblast growth?. ### Response: LMWH.


Instruction: How many small prospective clinical studies have been reported on the effects?

Output: Three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many small prospective clinical studies have been reported on the effects?. ### Response: Three.


Instruction: How many women received enoxaparin during pregnancy?

Output: 16

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many women received enoxaparin during pregnancy?. ### Response: 16.


Instruction: What did the fi rst study measure?

Output: bone mineral density

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the fi rst study measure?. ### Response: bone mineral density.


Instruction: How long after starting therapy were the bone density measurements taken?

Output: 2 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after starting therapy were the bone density measurements taken?. ### Response: 2 weeks.


Instruction: How long did enoxaparin last?

Output: 25 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did enoxaparin last?. ### Response: 25 weeks.


Instruction: What was the mean bone density at 6 weeks postpartum?

Output: P   5  .02

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean bone density at 6 weeks postpartum?. ### Response: P   5  .02.


Instruction: What percentage decrease in bone mass did no patient experience at 6 weeks postpartum?

Output: 10%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage decrease in bone mass did no patient experience at 6 weeks postpartum?. ### Response: 10%.


Instruction: What percentage reduction in bone density did two of the 14 patients evaluated have?

Output: 14%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage reduction in bone density did two of the 14 patients evaluated have?. ### Response: 14%).


Instruction: How many patients had a sig-nifi cant reduction in mean bone density?

Output: two of the 14

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had a sig-nifi cant reduction in mean bone density?. ### Response: two of the 14.


Instruction: How many patients evaluated had a. 10% decrease in VTE?

Output: 14

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients evaluated had a. 10% decrease in VTE?. ### Response: 14.


Instruction: How many pregnant women were included in the second study?

Output: 44

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many pregnant women were included in the second study?. ### Response: 44.


Instruction: What was LMWH?

Output: enoxaparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was LMWH?. ### Response: enoxaparin.


Instruction: What was performed at 1, 6, 16, and 52 weeks?

Output: Dual x-ray absorptiometry of the lumbosacral spine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was performed at 1, 6, 16, and 52 weeks?. ### Response: Dual x-ray absorptiometry of the lumbosacral spine.


Instruction: What was a healthy untreated control group included for?

Output: compar-ison

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a healthy untreated control group included for?. ### Response: compar-ison.


Instruction: What was the mean bone density of the lumbar spine in the UFH group?

Output: lower

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean bone density of the lumbar spine in the UFH group?. ### Response: lower.


Instruction: What did not differ between the dalteparin and control groups?

Output: Bone density mea sure-ments

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did not differ between the dalteparin and control groups?. ### Response: Bone density mea sure-ments.


Instruction: How many weeks was a healthy untreated control group included for comparison?

Output: 52

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many weeks was a healthy untreated control group included for comparison?. ### Response: 52.


Instruction: What did the third clinical trial compare the effects of long-term treatment with LMWH and acenocoumarol on in 86 patients with VTE?

Output: bone mineral density

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the third clinical trial compare the effects of long-term treatment with LMWH and acenocoumarol on in 86 patients with VTE?. ### Response: bone mineral density.


Instruction: How long was the treatment given for?

Output: 3 to 24 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the treatment given for?. ### Response: 3 to 24 months.


Instruction: What was the duration of the treatment?

Output: 3 to 24 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the duration of the treatment?. ### Response: 3 to 24 months.


Instruction: What was the mean decrease in bone density of the femur in patients given acenocoumarol?

Output: 1.8% and 2.6%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean decrease in bone density of the femur in patients given acenocoumarol?. ### Response: 1.8% and 2.6%.


Instruction: At 1 and 2 years of follow-up, what was the decrease of bone density?

Output: 1.8% and 2.6%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: At 1 and 2 years of follow-up, what was the decrease of bone density?. ### Response: 1.8% and 2.6%.


Instruction: What was not statistically signifi cant?

Output: mean bone density

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not statistically signifi cant?. ### Response: mean bone density.


Instruction: What is the strength of the association between LMWH and osteoporosis?

Output: unclear

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the strength of the association between LMWH and osteoporosis?. ### Response: unclear.


Instruction: What preparations have the potential to produce osteopenia?

Output: UFH and LMWH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What preparations have the potential to produce osteopenia?. ### Response: UFH and LMWH.


Instruction: What is the risk of osteopenia?

Output: lower with LMWH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of osteopenia?. ### Response: lower with LMWH.


Instruction: What is lower with LMWH?

Output: The risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is lower with LMWH?. ### Response: The risk.


Instruction: When was the American College of Chest Physicians founded?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the American College of Chest Physicians founded?. ### Response: 2012.


Instruction: S11.4-1. Nunes KP, Labazi H, Webb RC. New insights into what?

Output: hypertension-associated erectile dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: S11.4-1. Nunes KP, Labazi H, Webb RC. New insights into what?. ### Response: hypertension-associated erectile dysfunction.


Instruction: Curr Opin Nephrol Hypertens. 2012;21:163–70.

Output: S11.4-1. Nunes KP, Labazi H, Webb RC. New insights into hypertension-associated erectile dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Curr Opin Nephrol Hypertens. 2012;21:163–70.. ### Response: S11.4-1. Nunes KP, Labazi H, Webb RC. New insights into hypertension-associated erectile dysfunction.


Instruction: Johannes CB, Araujo AB, Feldman HA, et al. Incidence of erectile dysfunction in men 40 to 69?

Output: longitudinal results from the Massachusetts male aging study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Johannes CB, Araujo AB, Feldman HA, et al. Incidence of erectile dysfunction in men 40 to 69?. ### Response: longitudinal results from the Massachusetts male aging study.


Instruction: What is the name of the study that examined the aging of males in the United States?

Output: Massachusetts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined the aging of males in the United States?. ### Response: Massachusetts.


Instruction: What is a possible consequence of the increase in erectile dysfunction between 1995 and 2025?

Output: policy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a possible consequence of the increase in erectile dysfunction between 1995 and 2025?. ### Response: policy.


Instruction: When was the BJU Int. 84:50-6?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the BJU Int. 84:50-6?. ### Response: 1999.


Instruction: What is a disease marker for cardiovascular disease?

Output: Erectile dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a disease marker for cardiovascular disease?. ### Response: Erectile dysfunction.


Instruction: What is Martin SA, Atlantis E, Lange K, et al. Predictors of sexual dys-function in men?

Output: incidence and remission

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Martin SA, Atlantis E, Lange K, et al. Predictors of sexual dys-function in men?. ### Response: incidence and remission.


Instruction: What are the predictors of sexual dys-function incidence and remission in men?

Output: Antihypertensive drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the predictors of sexual dys-function incidence and remission in men?. ### Response: Antihypertensive drugs.


Instruction: What is the current state-of-the-art on systemic arterial hypertension and atherosclerosis?

Output: Novel therapeutic tar -gets for phosphodiesterase 5 inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the current state-of-the-art on systemic arterial hypertension and atherosclerosis?. ### Response: Novel therapeutic tar -gets for phosphodiesterase 5 inhibitors.


Instruction: What is Phosphodiesterase 5 inhibition in?

Output: essential hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Phosphodiesterase 5 inhibition in?. ### Response: essential hypertension.


Instruction: What is Curr Hypertens Rep 2008.10:52-7.

Output: essential hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Curr Hypertens Rep 2008.10:52-7.. ### Response: essential hypertension.


Instruction: What are the recommendations for antihypertensive drugs and male sexual dysfunction?

Output: adult hyperten-sion guideline recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the recommendations for antihypertensive drugs and male sexual dysfunction?. ### Response: adult hyperten-sion guideline recommendations.


Instruction: What are hypertension guideline recommendations?

Output: Antihypertensive drugs and male sexual dysfunction: a review of adult hyperten-sion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are hypertension guideline recommendations?. ### Response: Antihypertensive drugs and male sexual dysfunction: a review of adult hyperten-sion.


Instruction: What are patients undergoing surgical procedures S11.5-1?

Output: Patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients undergoing surgical procedures S11.5-1?. ### Response: Patients.


Instruction: How does perioperative beta-blocker therapy affect mortality after major noncardiac surgery?

Output: mortality and cardiovascular morbidity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does perioperative beta-blocker therapy affect mortality after major noncardiac surgery?. ### Response: mortality and cardiovascular morbidity.


Instruction: What is the association between perioperative beta-blockade withdrawal and mortality in vascular surgical patients?

Output: Increase of 1-year mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association between perioperative beta-blockade withdrawal and mortality in vascular surgical patients?. ### Response: Increase of 1-year mortality.


Instruction: What is Wallace AW, Au S, Cason BA's affiliation with?

Output: pattern of use of perioperative β-blockade and postoperative mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Wallace AW, Au S, Cason BA's affiliation with?. ### Response: pattern of use of perioperative β-blockade and postoperative mortality.


Instruction: When was Anesthesiology published?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Anesthesiology published?. ### Response: 2010.


Instruction: What does -blocker therapy have to do with risks of adverse cardiovascular events and deaths in patients with ischemic heart disease undergoing noncar -diac surgery?

Output: mortality and cardiovascular morbidity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does -blocker therapy have to do with risks of adverse cardiovascular events and deaths in patients with ischemic heart disease undergoing noncar -diac surgery?. ### Response: mortality and cardiovascular morbidity.


Instruction: What is the JAMA Intern Med 2014174:336-44?

Output: Association of β-blocker therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the JAMA Intern Med 2014174:336-44?. ### Response: Association of β-blocker therapy.


Instruction: What is the effect of beta-blocker withdrawal on 1-year mortality in endovascular and vascular surgery patients?

Output: Increase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of beta-blocker withdrawal on 1-year mortality in endovascular and vascular surgery patients?. ### Response: Increase.


Instruction: What is Barrett TW, Mori M, De Boer D?

Output: Association of ambulatory use of statins and beta-blockers with long-term mortality after vascular surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Barrett TW, Mori M, De Boer D?. ### Response: Association of ambulatory use of statins and beta-blockers with long-term mortality after vascular surgery.


Instruction: What are statins and beta-blockers associated with after vascular surgery?

Output: long-term mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are statins and beta-blockers associated with after vascular surgery?. ### Response: long-term mortality.


Instruction: What is perioperative -blockade associated with?

Output: mortality and cardiovascular morbidity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is perioperative -blockade associated with?. ### Response: mortality and cardiovascular morbidity.


Instruction: When did JAMA issue 309:1704-13?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did JAMA issue 309:1704-13?. ### Response: 2013.


Instruction: What percentage of untreated isolated distal DVT are expected to subsequently extend into the popliteal vein and may cause PE?

Output: 15%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of untreated isolated distal DVT are expected to subsequently extend into the popliteal vein and may cause PE?. ### Response: 15%.


Instruction: What is not acceptable to neither anticoagulate nordo surveillance to detect thrombus extension?

Output: about 15% of untreated isolated distal DVT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not acceptable to neither anticoagulate nordo surveillance to detect thrombus extension?. ### Response: about 15% of untreated isolated distal DVT.


Instruction: Anticoagulate nordo surveillance to detect thrombus extension?

Output: surveillance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Anticoagulate nordo surveillance to detect thrombus extension?. ### Response: surveillance.


Instruction: In AT9, what was effective for thetreatment of proximal DVT and PE?

Output: anticoagulant therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In AT9, what was effective for thetreatment of proximal DVT and PE?. ### Response: anticoagulant therapy.


Instruction: Why did patients with isolated distal DVT have lower risk of progressive or recurrent VTE?

Output: uncertainty thatthe bene ﬁts of anticoagulation outweigh its risks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why did patients with isolated distal DVT have lower risk of progressive or recurrent VTE?. ### Response: uncertainty thatthe bene ﬁts of anticoagulation outweigh its risks.


Instruction: Why do people with DVT have a lower risk of progressive or recurrent VTE?

Output: inpatients with isolated distal DVT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why do people with DVT have a lower risk of progressive or recurrent VTE?. ### Response: inpatients with isolated distal DVT.


Instruction: What would favor anticoagulation over surveillance?

Output: risk factors for extension of distal DVT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would favor anticoagulation over surveillance?. ### Response: risk factors for extension of distal DVT.


Instruction: How long is thrombosis?

Output: >5 cm in length

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is thrombosis?. ### Response: >5 cm in length.


Instruction: What is thrombosis con fined to the muscular veins of thecalf?

Output: lower risk ofextension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is thrombosis con fined to the muscular veins of thecalf?. ### Response: lower risk ofextension.


Instruction: What is there no reversibleprovoking factor for?

Output: DVT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is there no reversibleprovoking factor for?. ### Response: DVT.


Instruction: What veins are fined to the muscular veins of thecalf to have a lower risk oftension than thrombosis that involves the axial(ie, true deep; peroneal, tibial) veins?

Output: thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What veins are fined to the muscular veins of thecalf to have a lower risk oftension than thrombosis that involves the axial(ie, true deep; peroneal, tibial) veins?. ### Response: thrombosis.


Instruction: What type ofsymptoms favor anticoagulation?

Output: Severes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type ofsymptoms favor anticoagulation?. ### Response: Severes.


Instruction: A high risk for bleeding favors what type of surveillance?

Output: serial imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A high risk for bleeding favors what type of surveillance?. ### Response: serial imaging.


Instruction: What is expected to be sensitive to patient preferences?

Output: agulation or surveillance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is expected to be sensitive to patient preferences?. ### Response: agulation or surveillance.


Instruction: DistalDVT that are detected using a selective approach towhole-leg US will often satisfy criteria for initialanticoagulation?

Output: surveillance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: DistalDVT that are detected using a selective approach towhole-leg US will often satisfy criteria for initialanticoagulation?. ### Response: surveillance.


Instruction: What did not identify any newrandomized trials?

Output: The updated literature search

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did not identify any newrandomized trials?. ### Response: The updated literature search.


Instruction: Did the updated literature search identify any new randomized trials that assessed management of patients with isolated distal DVT?

Output: did not

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Did the updated literature search identify any new randomized trials that assessed management of patients with isolated distal DVT?. ### Response: did not.


Instruction: What did two new systematic reviews76,77and a narrative review83address?

Output: treatment of isolated distal DV

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did two new systematic reviews76,77and a narrative review83address?. ### Response: treatment of isolated distal DV.


Instruction: In addition to summarizing available data, what did they emphasize?

Output: the limitations of available evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In addition to summarizing available data, what did they emphasize?. ### Response: the limitations of available evidence.


Instruction: The panel endorsed the AT9 recommendations without what?

Output: revision

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The panel endorsed the AT9 recommendations without what?. ### Response: revision.


Instruction: What is the ability to predict in patients with acute isolated distal DVT limited?

Output: ension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ability to predict in patients with acute isolated distal DVT limited?. ### Response: ension.


Instruction: What is limited in patients with acute isolated distal DVT of the leg?

Output: ability to predictextension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is limited in patients with acute isolated distal DVT of the leg?. ### Response: ability to predictextension.


Instruction: How long do we suggest serial imaging of thedeep veins?

Output: 2 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long do we suggest serial imaging of thedeep veins?. ### Response: 2 weeks.


Instruction: What is grade 2C?

Output: anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is grade 2C?. ### Response: anticoagulation.


Instruction: Patients at high risk for bleeding are more likely to bene fit from what?

Output: serial imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients at high risk for bleeding are more likely to bene fit from what?. ### Response: serial imaging.


Instruction: What is the difference between fondaparinux and enoxaparnin?

Output: Efficacy and safety

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between fondaparinux and enoxaparnin?. ### Response: Efficacy and safety.


Instruction: What was the outcome of the OASIS-5 trial?

Output: Efficacy and safety

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome of the OASIS-5 trial?. ### Response: Efficacy and safety.


Instruction: When was the J Am Coll Cardiol 2007 published?

Output: 50:1742–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol 2007 published?. ### Response: 50:1742–.


Instruction: What is enoxaparin used for in acute coronary syndromes?

Output: percutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is enoxaparin used for in acute coronary syndromes?. ### Response: percutaneous coronary intervention.


Instruction: What is the FUTURA/OASIS-8 randomized trial?

Output: Low-dose vs standard-dose unfrac-tionated heparin for percutaneous coronary intervention in acute coro-nary syndromes treated with fondaparinux

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the FUTURA/OASIS-8 randomized trial?. ### Response: Low-dose vs standard-dose unfrac-tionated heparin for percutaneous coronary intervention in acute coro-nary syndromes treated with fondaparinux.


Instruction: What is the name of the randomized trial of fondaparinux?

Output: FUTURA/OASIS-8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized trial of fondaparinux?. ### Response: FUTURA/OASIS-8.


Instruction: When was the FUTURA/OASIS-8 trial conducted?

Output: 64–76. 314

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the FUTURA/OASIS-8 trial conducted?. ### Response: 64–76. 314.


Instruction: What was the effect on mortality and reinfarction in patients with acute ST-segment eleva-tion myocardial infarction?

Output: fondaparinux

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the effect on mortality and reinfarction in patients with acute ST-segment eleva-tion myocardial infarction?. ### Response: fondaparinux.


Instruction: What reduces the incidence of myocardial infarction and death in patients with unstable angina?

Output: Adding heparin to aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What reduces the incidence of myocardial infarction and death in patients with unstable angina?. ### Response: Adding heparin to aspirin.


Instruction: What does adding heparin to aspirin reduce?

Output: the incidence of myocardial infarction and death in patients with unstable angina

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does adding heparin to aspirin reduce?. ### Response: the incidence of myocardial infarction and death in patients with unstable angina.


Instruction: What is used to treat acute unstable angina?

Output: Aspirin, heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used to treat acute unstable angina?. ### Response: Aspirin, heparin.


Instruction: What is the risk of myocardial infarction and death during treatment with low dose aspirin and intravenous heparin in men with unstable coronary artery dis-ease?

Output: 318

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of myocardial infarction and death during treatment with low dose aspirin and intravenous heparin in men with unstable coronary artery dis-ease?. ### Response: 318.


Instruction: What is the name of the pilot study from the Antithrombotic Therapy in Acute Coronary Syndromes Study Group?

Output: FUTURA/OASIS-8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the pilot study from the Antithrombotic Therapy in Acute Coronary Syndromes Study Group?. ### Response: FUTURA/OASIS-8.


Instruction: What is the name of the study that evaluated antithrombotic therapy in unstable rest angina and non-Q-wave infarction in nonprior aspirin users?

Output: ATACS trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated antithrombotic therapy in unstable rest angina and non-Q-wave infarction in nonprior aspirin users?. ### Response: ATACS trial.


Instruction: What was the primary end point analysis from the ATACS trial?

Output: Combination antithrombotic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary end point analysis from the ATACS trial?. ### Response: Combination antithrombotic therapy.


Instruction: What group studies the effects of aspirin and heparin on transient myocardial ischemia and in-hospital prognosis in patients with unstable angina?

Output: meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What group studies the effects of aspirin and heparin on transient myocardial ischemia and in-hospital prognosis in patients with unstable angina?. ### Response: meta-analysis.


Instruction: What is the name of the research group that studies the effect of Aspirin alone and Heparin?

Output: The RISC Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the research group that studies the effect of Aspirin alone and Heparin?. ### Response: The RISC Group.


Instruction: When did the J Am Coll Cardiol. 1994;24:39–45?

Output: 322

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the J Am Coll Cardiol. 1994;24:39–45?. ### Response: 322.


Instruction: What is the difference between low molecular weight heparin and aspirin in the treatment of unstable angina and silent ischemia?

Output: regular heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between low molecular weight heparin and aspirin in the treatment of unstable angina and silent ischemia?. ### Response: regular heparin.


Instruction: What is a parenteral anticoagulant called?

Output: Antithrombotic Therapy and Prevention of Thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a parenteral anticoagulant called?. ### Response: Antithrombotic Therapy and Prevention of Thrombosis.


Instruction: Who is the author of Antithrombotic Therapy and Prevention?

Output: Garcia DA, Baglin TP, Weitz JI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of Antithrombotic Therapy and Prevention?. ### Response: Garcia DA, Baglin TP, Weitz JI.


Instruction: Who wrote Parenteral anticoagulants: Antithrombotic Therapy and Prevention of Thrombosis?

Output: Garcia DA, Baglin TP, Weitz JI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote Parenteral anticoagulants: Antithrombotic Therapy and Prevention of Thrombosis?. ### Response: Garcia DA, Baglin TP, Weitz JI.


Instruction: What is the name of the 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines?

Output: Antithrombotic Therapy and Prevention of Thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines?. ### Response: Antithrombotic Therapy and Prevention of Thrombosis.


Instruction: Chest. 2012;141:e24S–43S. 324.

Output: parin and aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Chest. 2012;141:e24S–43S. 324.. ### Response: parin and aspirin.


Instruction: What year did ACC/AHA/SCAI focus on primary percutaneous coronary intervention forpatients with coronary heart disease?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did ACC/AHA/SCAI focus on primary percutaneous coronary intervention forpatients with coronary heart disease?. ### Response: 2015.


Instruction: What is the primary percutaneous coronary intervention forpatients with ST-elevation myocardial infarction?

Output: an update of the 2011 ACCF/AHA/SCAI guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary percutaneous coronary intervention forpatients with ST-elevation myocardial infarction?. ### Response: an update of the 2011 ACCF/AHA/SCAI guideline.


Instruction: What guideline did the ACCF/AHA/SCAI update in 2011?

Output: percutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What guideline did the ACCF/AHA/SCAI update in 2011?. ### Response: percutaneous coronary intervention.


Instruction: What is the American College of Cardiology/American Heart Association Tas k Force onClinical Practice Guidelines?

Output: a report of the American College of Cardiology/American Heart Association Tas k Force onClinical Practice Guidelines and the Society for Cardiovascular Angiography and Interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the American College of Cardiology/American Heart Association Tas k Force onClinical Practice Guidelines?. ### Response: a report of the American College of Cardiology/American Heart Association Tas k Force onClinical Practice Guidelines and the Society for Cardiovascular Angiography and Interventions.


Instruction: What does the Society for Cardiovascular Angiography and Interventions do?

Output: a report of the American College of Cardiology/American Heart Association Tas k Force onClinical Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Society for Cardiovascular Angiography and Interventions do?. ### Response: a report of the American College of Cardiology/American Heart Association Tas k Force onClinical Practice Guidelines.


Instruction: What is available on the World Wide Web sites of the American College of Cardiology?

Output: Copies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is available on the World Wide Web sites of the American College of Cardiology?. ### Response: Copies.


Instruction: Where is the American Heart Association?

Output: my.americanheart.org

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the American Heart Association?. ### Response: my.americanheart.org.


Instruction: What is the Society for Cardiovascular Angiography and Interventions?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Society for Cardiovascular Angiography and Interventions?. ### Response: www.scai.org.


Instruction: How can you contact the Elsevier Re-prints Department?

Output: via fax

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can you contact the Elsevier Re-prints Department?. ### Response: via fax.


Instruction: What is not permitted without the express permission of theAmerican College of Cardiology?

Output: Multiple copies, modi ﬁcation, alteration, enhancement, and/or distribution of this document

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not permitted without the express permission of theAmerican College of Cardiology?. ### Response: Multiple copies, modi ﬁcation, alteration, enhancement, and/or distribution of this document.


Instruction: Where can you request permission to re-use elsevier material?

Output: online via the Elsevier site

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you request permission to re-use elsevier material?. ### Response: online via the Elsevier site.


Instruction: Where can one obtain permission to re-use elsevier material?

Output: online via the Elsevier site

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can one obtain permission to re-use elsevier material?. ### Response: online via the Elsevier site.


Instruction: What is the name of the website that Elsevier provides access to?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the website that Elsevier provides access to?. ### Response: http://www.elsevier.com.


Instruction: When was the Focused Update on Primary PCI released?

Output: MARCH 15, 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Focused Update on Primary PCI released?. ### Response: MARCH 15, 2016.


Instruction: What is t he clinical and cost eff ectiv eness of st opping anticoagulation in people whose atrial fibrillation has r esolv ed aft er ablation?

Output: Stopping an ticoagula tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is t he clinical and cost eff ectiv eness of st opping anticoagulation in people whose atrial fibrillation has r esolv ed aft er ablation?. ### Response: Stopping an ticoagula tion.


Instruction: What is the shor t explanation of wh y the committ ee made?

Output: discontinuing anticoagulation in people whose atrial fibrillation has r esolv ed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the shor t explanation of wh y the committ ee made?. ### Response: discontinuing anticoagulation in people whose atrial fibrillation has r esolv ed.


Instruction: What is the rationale for discontinuing anticoagulation in people with atrial fibrillation?

Output: has r esolv ed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the rationale for discontinuing anticoagulation in people with atrial fibrillation?. ### Response: has r esolv ed.


Instruction: What is t he rationale on resear ch?

Output: discontinuing anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is t he rationale on resear ch?. ### Response: discontinuing anticoagulation.


Instruction: What is t he clinical and cost eff ectiveness of st opping anticoagulation in people whose postoperativ e atrial fibrillation has r esolv ed?

Output: Stopping an ticoagula tion af ter r esolution o f postoper ative atrial fibrilla tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is t he clinical and cost eff ectiveness of st opping anticoagulation in people whose postoperativ e atrial fibrillation has r esolv ed?. ### Response: Stopping an ticoagula tion af ter r esolution o f postoper ative atrial fibrilla tion.


Instruction: What is the rationale on st opping anticoagulation?

Output: discontinuing anticoagulation in people whose atrial fibrillation has r esolv ed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the rationale on st opping anticoagulation?. ### Response: discontinuing anticoagulation in people whose atrial fibrillation has r esolv ed.


Instruction: What is a postoperativ e atrial fibrillation aft er car diac surgery?

Output: diagnosis and management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a postoperativ e atrial fibrillation aft er car diac surgery?. ### Response: diagnosis and management.


Instruction: What is t he rationale on st opping anticoagulation?

Output: discontinuing anticoagulation in people whose atrial fibrillation has r esolv ed. 5 Cogni tive beha viour al ther apy for pe ople wi th atrial fi brilla tion What is t he clinical and cost eff ectiv eness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is t he rationale on st opping anticoagulation?. ### Response: discontinuing anticoagulation in people whose atrial fibrillation has r esolv ed. 5 Cogni tive beha viour al ther apy for pe ople wi th atrial fi brilla tion What is t he clinical and cost eff ectiv eness.


Instruction: What are full details of?

Output: t he evidence and t he committ ee's discussion ar e in evidence r eview

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are full details of?. ### Response: t he evidence and t he committ ee's discussion ar e in evidence r eview.


Instruction: What is cognitive beha viour al ther apy for pe ople wi th atrial fi brillation?

Output: What is t he clinical and cost eff ectiv eness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is cognitive beha viour al ther apy for pe ople wi th atrial fi brillation?. ### Response: What is t he clinical and cost eff ectiv eness.


Instruction: What is t he clinical and cost eff ectiveness of cognitiv e behavioural t herap y compar ed for people wit h newly diagnosed?

Output: Cogni tive beha viour al ther apy for pe ople wi th atrial fi brilla tion What is t he clinical and cost eff ectiv eness of cognitiv e beha vioural

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is t he clinical and cost eff ectiveness of cognitiv e behavioural t herap y compar ed for people wit h newly diagnosed?. ### Response: Cogni tive beha viour al ther apy for pe ople wi th atrial fi brilla tion What is t he clinical and cost eff ectiv eness of cognitiv e beha vioural.


Instruction: What is the usual car e for people wit h newly diagnosed atrial fibrillation?

Output: cognitiv e

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the usual car e for people wit h newly diagnosed atrial fibrillation?. ### Response: cognitiv e.


Instruction: What is t he comparativ e eff ectiv eness of the 3 main drugs?

Output: Ra te-control drug

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is t he comparativ e eff ectiv eness of the 3 main drugs?. ### Response: Ra te-control drug.


Instruction: How many main drug classes are used in people with atrial fibrillation?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many main drug classes are used in people with atrial fibrillation?. ### Response: 3.


Instruction: What are the three main drugs used?

Output: beta-block ers, calcium-channel block ers and digo xin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the three main drugs used?. ### Response: beta-block ers, calcium-channel block ers and digo xin.


Instruction: How old are the people who use the 3 main drugs?

Output: 7 5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old are the people who use the 3 main drugs?. ### Response: 7 5.


Instruction: Atrial fibrillation: diagnosis and management (NG196) NICE 2022. Subject t o Notice of right s (http://www.nice.org.uk/t erms-and-conditions#notice-of-right s)

Output: All right s reserved

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atrial fibrillation: diagnosis and management (NG196) NICE 2022. Subject t o Notice of right s (http://www.nice.org.uk/t erms-and-conditions#notice-of-right s). ### Response: All right s reserved.


Instruction: What is a risk factor for bleeding in patients with UA/NSTEMI undergoing PCI as part of an early invasive strategy?

Output: Patients weighing /H1102160 kg have an increased exposure to the active metabolite of prasugrel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for bleeding in patients with UA/NSTEMI undergoing PCI as part of an early invasive strategy?. ### Response: Patients weighing /H1102160 kg have an increased exposure to the active metabolite of prasugrel.


Instruction: What drug was replaced with P2Y12 receptorinhibitor?

Output: clopidogrel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug was replaced with P2Y12 receptorinhibitor?. ### Response: clopidogrel.


Instruction: What is the loading dose of clopidogrel?

Output: 600 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the loading dose of clopidogrel?. ### Response: 600 mg.


Instruction: How long does it take to take 150 mg daily for 6 days?

Output: 75

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take to take 150 mg daily for 6 days?. ### Response: 75.


Instruction: What may bereasonable in patients not at high risk for bleeding?

Output: 75 mg daily

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may bereasonable in patients not at high risk for bleeding?. ### Response: 75 mg daily.


Instruction: What is the class of evidence that abciximab should not be administered to patients in whom PCI is not planned?

Output: Class III: No Benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the class of evidence that abciximab should not be administered to patients in whom PCI is not planned?. ### Response: Class III: No Benefit.


Instruction: How many patients are at low risk for ischemic events in UA/NSTEMI patients?

Output: 113492

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients are at low risk for ischemic events in UA/NSTEMI patients?. ### Response: 113492.


Instruction: What is the TIMI risk score /H113492)?

Output: UA/NSTEMI patients who are at low risk for ischemic events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the TIMI risk score /H113492)?. ### Response: UA/NSTEMI patients who are at low risk for ischemic events.


Instruction: Upstream GP IIb/IIIa inhibitors are notrecommended.

Output: UA/NSTEMI patients who are at low risk for ischemic events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Upstream GP IIb/IIIa inhibitors are notrecommended.. ### Response: UA/NSTEMI patients who are at low risk for ischemic events.


Instruction: What was the 2011 recommendationmodified?

Output: “clopidogrel”replaced with “P2Y12receptorinhibitor”

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 2011 recommendationmodified?. ### Response: “clopidogrel”replaced with “P2Y12receptorinhibitor”.


Instruction: What is prasugrel for patients with TIA?

Output: PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is prasugrel for patients with TIA?. ### Response: PCI.


Instruction: What is part of a dual antiplatelet therapy regimen?

Output: prasugrel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is part of a dual antiplatelet therapy regimen?. ### Response: prasugrel.


Instruction: Who has an increased risk of bleeding?

Output: 2160 kg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who has an increased risk of bleeding?. ### Response: 2160 kg.


Instruction: What is an increased risk of bleeding on a 10-mg once-daily maintenancedose?

Output: 2160 kg have an increased exposure to the active metabolite of prasugrel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an increased risk of bleeding on a 10-mg once-daily maintenancedose?. ### Response: 2160 kg have an increased exposure to the active metabolite of prasugrel.


Instruction: What should be considered when lowering the maintenance dose to 5 mg in patients who weigh /H1102160 kg?

Output: the effectiveness and safety of the 5-mgdose have not been studied prospectively

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered when lowering the maintenance dose to 5 mg in patients who weigh /H1102160 kg?. ### Response: the effectiveness and safety of the 5-mgdose have not been studied prospectively.


Instruction: How long should a daily maintenance dose be given for post-PCI patients?

Output: 12 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long should a daily maintenance dose be given for post-PCI patients?. ### Response: 12 months.


Instruction: What is the maximum amount of time given for patients receiving BMS?

Output: 12 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the maximum amount of time given for patients receiving BMS?. ### Response: 12 months.


Instruction: The risk of bleeding outweighs the net benefit afforded by a P2Y12receptor inhibitor.

Output: Do not use prasugrelin patients with active pathological bleeding or a history of TIA or stroke. In patients age /H1135075 years, prasugrel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The risk of bleeding outweighs the net benefit afforded by a P2Y12receptor inhibitor.. ### Response: Do not use prasugrelin patients with active pathological bleeding or a history of TIA or stroke. In patients age /H1135075 years, prasugrel.


Instruction: What is a P2Y12receptor inhibitor?

Output: clopidogrel orticagrelor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a P2Y12receptor inhibitor?. ### Response: clopidogrel orticagrelor.


Instruction: Do not use prasugrelin in patients with active pathological bleeding or a history of TIA or stroke?

Output: P2Y12receptor inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Do not use prasugrelin in patients with active pathological bleeding or a history of TIA or stroke?. ### Response: P2Y12receptor inhibitor.