Instruction: How many options are there for subcutaneous injection of Heparin?

Output: at least two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many options are there for subcutaneous injection of Heparin?. ### Response: at least two.


Instruction: What is the initial IV bolus of heparin?

Output: /H11601 5,000 units

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the initial IV bolus of heparin?. ### Response: /H11601 5,000 units.


Instruction: How many units/kg twice daily is recommended for acute hepatitis B?

Output: 250

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many units/kg twice daily is recommended for acute hepatitis B?. ### Response: 250.


Instruction: What are the initial subcutaneous doses of the hepatin used for?

Output: 333 units/kg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the initial subcutaneous doses of the hepatin used for?. ### Response: 333 units/kg.


Instruction: What are the doses of heparin for acute coronary syndromes lower than?

Output: those used to treat VTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the doses of heparin for acute coronary syndromes lower than?. ### Response: those used to treat VTE.


Instruction: What do the American College of Cardi-ology recommend?

Output: a heparin bolus of 60 to 70 units/kg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do the American College of Cardi-ology recommend?. ### Response: a heparin bolus of 60 to 70 units/kg.


Instruction: How many units/kg is recommended for a bolus of Heparin followed by an infusion of 12 to 15 units?

Output: 60 to 70

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many units/kg is recommended for a bolus of Heparin followed by an infusion of 12 to 15 units?. ### Response: 60 to 70.


Instruction: How many units of heparin per kg/h is recommended for unstable angina and non-ST-segment elevation myocardial infarction?

Output: 12 to 15

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many units of heparin per kg/h is recommended for unstable angina and non-ST-segment elevation myocardial infarction?. ### Response: 12 to 15.


Instruction: What is recom-mended when given in conjunction with fi brinolytic agents for treatment?

Output: heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recom-mended when given in conjunction with fi brinolytic agents for treatment?. ### Response: heparin.


Instruction: How much is the bolus about?

Output: 60 units/kg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much is the bolus about?. ### Response: 60 units/kg.


Instruction: What is the bolus of ST-segment ele-vation myocardial infarction?

Output: 60 units/kg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the bolus of ST-segment ele-vation myocardial infarction?. ### Response: 60 units/kg.


Instruction: How many units/kg of heparin is given per day?

Output: 250

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many units/kg of heparin is given per day?. ### Response: 250.


Instruction: What is a maximum of 1,000 units/h of infusion?

Output: 12 to 15 units/kg/h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a maximum of 1,000 units/h of infusion?. ### Response: 12 to 15 units/kg/h.


Instruction: What is the risk of bleeding increased by recent surgery, trauma, invasive procedures, or concomitant hemo-static defects?

Output: 61,62

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of bleeding increased by recent surgery, trauma, invasive procedures, or concomitant hemo-static defects?. ### Response: 61,62.


Instruction: What are hemostatic defects?

Output: recurrent thromboem-bolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are hemostatic defects?. ### Response: recurrent thromboem-bolism.


Instruction: What increase the risk of anticoagulant-associated bleeding in hospitalized patients?

Output: increasing number of comorbidities, age  .  60 y, suprathera-peutic clotting times, and worsening hepatic dysfunc-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What increase the risk of anticoagulant-associated bleeding in hospitalized patients?. ### Response: increasing number of comorbidities, age  .  60 y, suprathera-peutic clotting times, and worsening hepatic dysfunc-tion.


Instruction: How long does suprathera-peutic clotting times and worsening hepatic dysfunction take?

Output: 60 y

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does suprathera-peutic clotting times and worsening hepatic dysfunction take?. ### Response: 60 y.


Instruction: What is a relationship between the dose of heparin administered and its effi -cacy 33,47,65 and safety?

Output: Investigators have reported

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a relationship between the dose of heparin administered and its effi -cacy 33,47,65 and safety?. ### Response: Investigators have reported.


Instruction: What is it stan-dard practice to monitor and adjust the dose based on the results of a patient's anticoagulant response?

Output: coagulation tests

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is it stan-dard practice to monitor and adjust the dose based on the results of a patient's anticoagulant response?. ### Response: coagulation tests.


Instruction: What is the evidence for adjusting the dose of heparin to main-tain a “therapeutic range”?

Output: weak

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the evidence for adjusting the dose of heparin to main-tain a “therapeutic range”?. ### Response: weak.


Instruction: What is based on a post hoc subgroup analysis of a descriptive study?

Output: The evidence for adjusting the dose of heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is based on a post hoc subgroup analysis of a descriptive study?. ### Response: The evidence for adjusting the dose of heparin.


Instruction: How long should aspirin be taken postoperatively?

Output: 6 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long should aspirin be taken postoperatively?. ### Response: 6 hours.


Instruction: What is the recommended dose of aspirine?

Output: 100 mg to 325 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommended dose of aspirine?. ### Response: 100 mg to 325 mg.


Instruction: Where can you find the 2011 ACCF/AHA CABG Guideline e677?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find the 2011 ACCF/AHA CABG Guideline e677?. ### Response: http://ahajournals.org.


Instruction: What is exercise type and intensity in relation to in men?

Output: coronary heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is exercise type and intensity in relation to in men?. ### Response: coronary heart disease.


Instruction: What is a meta-analysis of physical activity in the pre-vention of coronary heart disease?

Output: JAMA. 2002;288:1994–2000. 342. Berlin JA, Colditz GA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a meta-analysis of physical activity in the pre-vention of coronary heart disease?. ### Response: JAMA. 2002;288:1994–2000. 342. Berlin JA, Colditz GA.


Instruction: How long did the MRFIT trial last?

Output: 10.5 year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the MRFIT trial last?. ### Response: 10.5 year.


Instruction: What is the name of the trial that examined physical activity and 10.5 year mortality?

Output: Multiple Risk Factor Intervention Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the trial that examined physical activity and 10.5 year mortality?. ### Response: Multiple Risk Factor Intervention Trial.


Instruction: What does smoking cessation have to do with mortality rates in women?

Output: decreased risks of coronary heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does smoking cessation have to do with mortality rates in women?. ### Response: decreased risks of coronary heart disease.


Instruction: What is the name of the prospective cohort study?

Output: 10 Small Steps Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective cohort study?. ### Response: 10 Small Steps Study.


Instruction: When was the Ann Intern Med published?

Output: 1993

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Ann Intern Med published?. ### Response: 1993.


Instruction: What did smoking cessation and decreased risk of stroke in women do?

Output: Lifestyle intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did smoking cessation and decreased risk of stroke in women do?. ### Response: Lifestyle intervention.


Instruction: What was the JAMA's 1993 issue 269:232–236?

Output: 346

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the JAMA's 1993 issue 269:232–236?. ### Response: 346.


Instruction: Kawachi I, Colditz GA, Stampfer MJ, Willett WC, Manson JE, Rosner B, Speizer FE, Hennekens CH. What did Smoking Cessation reduce in middle-aged women?

Output: coronary heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Kawachi I, Colditz GA, Stampfer MJ, Willett WC, Manson JE, Rosner B, Speizer FE, Hennekens CH. What did Smoking Cessation reduce in middle-aged women?. ### Response: coronary heart disease.


Instruction: What are the risks of coronary heart disease in middle-aged women?

Output: decreased risks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the risks of coronary heart disease in middle-aged women?. ### Response: decreased risks.


Instruction: What is the name of the journal that studies the relationship between alcohol consumption and mor-tality?

Output: BMJ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies the relationship between alcohol consumption and mor-tality?. ### Response: BMJ.


Instruction: What are the results of the National Health Interview Surveys?

Output: Alcohol intake and mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of the National Health Interview Surveys?. ### Response: Alcohol intake and mortality.


Instruction: What is the impact of a healthy lifestyle on all-cause and cardiovascular mortality after stroke in the USA?

Output: 349

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact of a healthy lifestyle on all-cause and cardiovascular mortality after stroke in the USA?. ### Response: 349.


Instruction: What year was the DEPLAN study conducted in Greece?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the DEPLAN study conducted in Greece?. ### Response: 2012.


Instruction: What is the name of the study done in Greece to prevent type 2 diabetes?

Output: DEPLAN study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study done in Greece to prevent type 2 diabetes?. ### Response: DEPLAN study.


Instruction: What did the DEPLAN study aim to prevent in Greece?

Output: type 2 diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the DEPLAN study aim to prevent in Greece?. ### Response: type 2 diabetes.


Instruction: What is the name of the Illinois WISEWOMAN Program?

Output: Lifestyle intervention and cardiovascular risk reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Illinois WISEWOMAN Program?. ### Response: Lifestyle intervention and cardiovascular risk reduction.


Instruction: What is the name of the program that reduces the number of women in the Illinois WISEWOMAN program?

Output: Smoking cessation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the program that reduces the number of women in the Illinois WISEWOMAN program?. ### Response: Smoking cessation.


Instruction: What is a possible way to delay the progression to type 2 diabetes among high-risk Spanish indi-viduals?

Output: intensive lifestyle intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a possible way to delay the progression to type 2 diabetes among high-risk Spanish indi-viduals?. ### Response: intensive lifestyle intervention.


Instruction: What type of diabetes is feasible in real-life primary healthcare settings using intensive lifestyle intervention?

Output: type 2 diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diabetes is feasible in real-life primary healthcare settings using intensive lifestyle intervention?. ### Response: type 2 diabetes.


Instruction: What is the name of the randomised controlled trial of an intervention to promote diabetes?

Output: 10 Small Steps Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised controlled trial of an intervention to promote diabetes?. ### Response: 10 Small Steps Study.


Instruction: What was the purpose of the study?

Output: to promote healthy behaviour

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the purpose of the study?. ### Response: to promote healthy behaviour.


Instruction: What did the study use to promote healthy behaviour using a lifestyle score and personalised feedback?

Output: 10 Small Steps Study: a randomised controlled trial of an intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the study use to promote healthy behaviour using a lifestyle score and personalised feedback?. ### Response: 10 Small Steps Study: a randomised controlled trial of an intervention.


Instruction: Who is labored with the Society for Cardiovascular Angiography and Interven-tions?

Output: Japanese Society of Echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is labored with the Society for Cardiovascular Angiography and Interven-tions?. ### Response: Japanese Society of Echocardiography.


Instruction: What is the Japanese Society of Echocardiography?

Output: Society for Cardiovascular Angiography and Interven-tions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Japanese Society of Echocardiography?. ### Response: Society for Cardiovascular Angiography and Interven-tions.


Instruction: How is multimodality imaging guidance for percutaneous paravalvular leak closure?

Output: Insights from the multi-centre FFPP register

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is multimodality imaging guidance for percutaneous paravalvular leak closure?. ### Response: Insights from the multi-centre FFPP register.


Instruction: Insights from the multi-centre FFPP register.

Output: Multimodality imaging guidance for percutaneous paravalvular leak closure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Insights from the multi-centre FFPP register.. ### Response: Multimodality imaging guidance for percutaneous paravalvular leak closure.


Instruction: What is the name of the instrument used to evaluate the success of percutaneous transcatheter closure of mitral paravalvular leaks?

Output: real-time three-dimensional transesophageal echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the instrument used to evaluate the success of percutaneous transcatheter closure of mitral paravalvular leaks?. ### Response: real-time three-dimensional transesophageal echocardiography.


Instruction: What year did J Am Soc Echocardiogr. 2010:23:26–32?

Output: 2019

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did J Am Soc Echocardiogr. 2010:23:26–32?. ### Response: 2019.


Instruction: What year did Soc Echocardiogr. 2010:23:26–32?

Output: 2019

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Soc Echocardiogr. 2010:23:26–32?. ### Response: 2019.


Instruction: What was left untreated at the time of aortic valve replacement?

Output: mitral regurgita-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was left untreated at the time of aortic valve replacement?. ### Response: mitral regurgita-tion.


Instruction: What is the name of the study that describes clinical trial principles and endpoint definitions for paravalvular leaks in surgical prosthesis?

Output: an expert state-ment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that describes clinical trial principles and endpoint definitions for paravalvular leaks in surgical prosthesis?. ### Response: an expert state-ment.


Instruction: What are the recommendations for image acquisition and display using EAE/ASE?

Output: three-dimensional echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the recommendations for image acquisition and display using EAE/ASE?. ### Response: three-dimensional echocardiography.


Instruction: What are the recommendations for image acquisition and display using three-dimensional echocardiography?

Output: EAE/ASE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the recommendations for image acquisition and display using three-dimensional echocardiography?. ### Response: EAE/ASE.


Instruction: When was the J Am Soc Echocardiogr. 2012:25:3–46?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Soc Echocardiogr. 2012:25:3–46?. ### Response: 2012.


Instruction: What is the role of paravalvular leak closure under intracardiac echocardiographic guidance?

Output: improved midterm survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of paravalvular leak closure under intracardiac echocardiographic guidance?. ### Response: improved midterm survival.


Instruction: What is a benchmark for transcatheter valve-in-valve procedures?

Output: Contemporary outcomes of re-peat aortic valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a benchmark for transcatheter valve-in-valve procedures?. ### Response: Contemporary outcomes of re-peat aortic valve replacement.


Instruction: What are the early and late results of the surgical correction of?

Output: cardiac prosthetic paravalvular leaks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the early and late results of the surgical correction of?. ### Response: cardiac prosthetic paravalvular leaks.


Instruction: What is the risk of reoperation for mitral valve replacement in patients 65 years old?

Output: Significant mitral regurgita-tion left untreated

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of reoperation for mitral valve replacement in patients 65 years old?. ### Response: Significant mitral regurgita-tion left untreated.


Instruction: What is the risk of reoperation for mitral bioprosthesis dysfunction?

Output: 4. Jaussaud N, Gariboldi V, Grisoli D, et al. Risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of reoperation for mitral bioprosthesis dysfunction?. ### Response: 4. Jaussaud N, Gariboldi V, Grisoli D, et al. Risk.


Instruction: What are the outcomes of percutaneous repair of paravalvular prosthetic regurgitation in 115 patients?

Output: acute and 30-day outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the outcomes of percutaneous repair of paravalvular prosthetic regurgitation in 115 patients?. ### Response: acute and 30-day outcomes.


Instruction: What year did Circ Cardiovasc Interv. 2011:4:314–21?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Circ Cardiovasc Interv. 2011:4:314–21?. ### Response: 2011.


Instruction: What is the name of the surgeon who performed long-term follow-up of percuta-neous repair of paravalvular prosthetic regurgitation?

Output: Sorajja P , Cabalka AK, Hagler DJ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the surgeon who performed long-term follow-up of percuta-neous repair of paravalvular prosthetic regurgitation?. ### Response: Sorajja P , Cabalka AK, Hagler DJ.


Instruction: What are the long-term outcomes of mitral paravalvular leak management?

Output: Transcatheter and surgical

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the long-term outcomes of mitral paravalvular leak management?. ### Response: Transcatheter and surgical.


Instruction: What is the JACC Cardiovasc Interv. 2017;10:1946–56?

Output: Transcatheter and surgical manage-ment of mitral paravalvular leak: long-term outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the JACC Cardiovasc Interv. 2017;10:1946–56?. ### Response: Transcatheter and surgical manage-ment of mitral paravalvular leak: long-term outcomes.


Instruction: How is successful percutaneous mitral Para-Valvular Leak closure associated with midterm survival?

Output: improved

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is successful percutaneous mitral Para-Valvular Leak closure associated with midterm survival?. ### Response: improved.


Instruction: What are the host factors associated with increased risk of CIED infection outlined in a previous section of this document?

Output: renal failure, corticosteroid use, congestive heartfailure, hematoma formation, diabetes mellitus, and antico-agulation use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the host factors associated with increased risk of CIED infection outlined in a previous section of this document?. ### Response: renal failure, corticosteroid use, congestive heartfailure, hematoma formation, diabetes mellitus, and antico-agulation use.


Instruction: What can present as different syndromes?

Output: DiagnosisCIED infection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can present as different syndromes?. ### Response: DiagnosisCIED infection.


Instruction: Antico-agulation use can present as different syndromes, what is it?

Output: right-sided (lead-related) and left-sided endo-carditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Antico-agulation use can present as different syndromes, what is it?. ### Response: right-sided (lead-related) and left-sided endo-carditis.


Instruction: Local inflammatory changes of thegenerator-pocket site are present in what percentage of cases?

Output: themajority

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Local inflammatory changes of thegenerator-pocket site are present in what percentage of cases?. ### Response: themajority.


Instruction: What usually prompts patients to seek medical attention?

Output: local changes, often accompanied by pain or discom-fort

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What usually prompts patients to seek medical attention?. ### Response: local changes, often accompanied by pain or discom-fort.


Instruction: Feverand other signs of systemic toxicity are often absent what symptoms do some patients present with?

Output: vague symptoms that includemalaise, fatigue, anorexia, or decreased functional capacity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Feverand other signs of systemic toxicity are often absent what symptoms do some patients present with?. ### Response: vague symptoms that includemalaise, fatigue, anorexia, or decreased functional capacity.


Instruction: Who harbors no localinflammatory changes at the generator-pocket site?

Output: patients with fever of undefined origin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who harbors no localinflammatory changes at the generator-pocket site?. ### Response: patients with fever of undefined origin.


Instruction: How many sets of blood cultures should be obtained before the initiation of antimicrobial therapy in all patients with suspected CIED infection?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many sets of blood cultures should be obtained before the initiation of antimicrobial therapy in all patients with suspected CIED infection?. ### Response: 2.


Instruction: Some patients with bloodstream infection may not have what?

Output: systemic toxicity or peripheral leukocytosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Some patients with bloodstream infection may not have what?. ### Response: systemic toxicity or peripheral leukocytosis.


Instruction: What is a strong clue that the clinical syndrome is due to CIED infection?

Output: Posi-tive blood cultures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a strong clue that the clinical syndrome is due to CIED infection?. ### Response: Posi-tive blood cultures.


Instruction: Patients should be educated about the need to be evaluated for what?

Output: CIED infection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients should be educated about the need to be evaluated for what?. ### Response: CIED infection.


Instruction: What is TEE?

Output: Transesophageal echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is TEE?. ### Response: Transesophageal echocardiography.


Instruction: What is not helpful in ruling out a diagnosis of lead-relatedendocarditis?

Output: ardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not helpful in ruling out a diagnosis of lead-relatedendocarditis?. ### Response: ardiography.


Instruction: What type of endocarditis is most common in adults?

Output: lead-related

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of endocarditis is most common in adults?. ### Response: lead-related.


Instruction: What is the sensitivity of TEE for left-sided involvement and perivalvular extension of infection superior to?

Output: transthoracic echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the sensitivity of TEE for left-sided involvement and perivalvular extension of infection superior to?. ### Response: transthoracic echocardiography.


Instruction: What may identify tissue along the superior vena cava that is difficult to visualize by other methods?

Output: visualizationof the lead in the proximal superior vena cava from TEEviews

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may identify tissue along the superior vena cava that is difficult to visualize by other methods?. ### Response: visualizationof the lead in the proximal superior vena cava from TEEviews.


Instruction: What is critical among patients with S aureus bacteremia because the rate ofendocarditis is significant?

Output: TEE examination

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is critical among patients with S aureus bacteremia because the rate ofendocarditis is significant?. ### Response: TEE examination.


Instruction: Several prognostic features might be better defined on what?

Output: transthoracic echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Several prognostic features might be better defined on what?. ### Response: transthoracic echocardiography.


Instruction: What type of echocardiography is more accurate than onTEE?

Output: transthoracic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of echocardiography is more accurate than onTEE?. ### Response: transthoracic.


Instruction: What can serve as a baseline for studies that may be required during the course of the patient's illness or follow up?

Output: Concomitant or subsequent transthoracic echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can serve as a baseline for studies that may be required during the course of the patient's illness or follow up?. ### Response: Concomitant or subsequent transthoracic echocardiography.


Instruction: What is a mass adhered to the lead that is seen on echocardiog-og?

Output: cutaneous erosion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a mass adhered to the lead that is seen on echocardiog-og?. ### Response: cutaneous erosion.


Instruction: What is the term for heart failure and atrial fibrillation?

Output: AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for heart failure and atrial fibrillation?. ### Response: AF.


Instruction: What is another name for echocardiography and cardiac MRI?

Output: repeated cardiac imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for echocardiography and cardiac MRI?. ### Response: repeated cardiac imaging.


Instruction: What is another name for cardiac imaging?

Output: echocardiography or cardiac MRI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for cardiac imaging?. ### Response: echocardiography or cardiac MRI.


Instruction: What are the two types of imaging studies?

Output: echocardiography or cardiac MRI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the two types of imaging studies?. ### Response: echocardiography or cardiac MRI.


Instruction: What is a pro-spective study that demonstrates the role of lamina terminalis fenes-tration combined with modern microsurgical cisternal blood evacuation?

Output: Improvedoutcome in high-grade aneurysmal subarachnoid hemorrhage byenhancement of endogenous clearance of cisternal blood clots

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a pro-spective study that demonstrates the role of lamina terminalis fenes-tration combined with modern microsurgical cisternal blood evacuation?. ### Response: Improvedoutcome in high-grade aneurysmal subarachnoid hemorrhage byenhancement of endogenous clearance of cisternal blood clots.


Instruction: What is improvedoutcome in high grade aneurysmal subarachnoid hemorrhage?

Output: enhancement of endogenous clearance of cisternal blood clots

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is improvedoutcome in high grade aneurysmal subarachnoid hemorrhage?. ### Response: enhancement of endogenous clearance of cisternal blood clots.


Instruction: What does microsurgical cisternal blood evacuation do?

Output: Improvedoutcome in high-grade aneurysmal subarachnoid hemorrhage byenhancement of endogenous clearance of cisternal blood clots

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does microsurgical cisternal blood evacuation do?. ### Response: Improvedoutcome in high-grade aneurysmal subarachnoid hemorrhage byenhancement of endogenous clearance of cisternal blood clots.


Instruction: What is one of the predisposing factors related to shunt-dependent chronic hydrocephalus after aneu-rysmal subarachnoid hemorrhage?

Output: lamina terminalisfenestration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the predisposing factors related to shunt-dependent chronic hydrocephalus after aneu-rysmal subarachnoid hemorrhage?. ### Response: lamina terminalisfenestration.


Instruction: What is the risk of rebleeding after treatment of acutehydrocephalus in patients with aneurysmal subarachnoid hemorrhage?

Output: shunt-dependent chronic hydrocephalus after aneu-rysmal subarachnoid hemorrhage. J Korean Neurosurg Soc . 2008;43:177–181.239. Hellingman CA, van den Bergh WM, Beijer IS, van Dijk GW, Algra A,van Gijn J, Rinkel GJ. Risk of rebleeding after treatment of acutehydrocephalus in patients with aneurysmal subarachnoid hemorrhage.Stroke . 2007;38:96–99.240

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of rebleeding after treatment of acutehydrocephalus in patients with aneurysmal subarachnoid hemorrhage?. ### Response: shunt-dependent chronic hydrocephalus after aneu-rysmal subarachnoid hemorrhage. J Korean Neurosurg Soc . 2008;43:177–181.239. Hellingman CA, van den Bergh WM, Beijer IS, van Dijk GW, Algra A,van Gijn J, Rinkel GJ. Risk of rebleeding after treatment of acutehydrocephalus in patients with aneurysmal subarachnoid hemorrhage.Stroke . 2007;38:96–99.240.


Instruction: When did Stroke. 2007:38:96-99.240?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Stroke. 2007:38:96-99.240?. ### Response: 2007.


Instruction: What type of hydrocephalus is predicted after aneurysmal subarachnoid hemor-rhage?

Output: Shunt-dependent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of hydrocephalus is predicted after aneurysmal subarachnoid hemor-rhage?. ### Response: Shunt-dependent.


Instruction: What is the name of the clinical article published in 2010?

Output: J Neurosurg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the clinical article published in 2010?. ### Response: J Neurosurg.


Instruction: What does Ruland S, RoitbergBZ predict in patients with aneurysmal subarachnoid hemorrhage?

Output: ventriculoperitoneal shunt dependency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Ruland S, RoitbergBZ predict in patients with aneurysmal subarachnoid hemorrhage?. ### Response: ventriculoperitoneal shunt dependency.


Instruction: What is shunt-dependent hydrocephalus after?

Output: aneurysmal subarachnoid hemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is shunt-dependent hydrocephalus after?. ### Response: aneurysmal subarachnoid hemorrhage.


Instruction: What does lamina terminalisfenestration reduce after an-eurysmal subarachnoid hemorrhage?

Output: shunt-dependent hydrocephalus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does lamina terminalisfenestration reduce after an-eurysmal subarachnoid hemorrhage?. ### Response: shunt-dependent hydrocephalus.


Instruction: What type of hydrocephalus is caused by neurosurgical and endovascular treatment of ruptured intracranial aneurysms?

Output: Chronic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of hydrocephalus is caused by neurosurgical and endovascular treatment of ruptured intracranial aneurysms?. ### Response: Chronic.


Instruction: What is the name of the study that compares rapid and gradual weaning from external ventricular drainage?

Output: a prospective randomized trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that compares rapid and gradual weaning from external ventricular drainage?. ### Response: a prospective randomized trial.


Instruction: What is the name of the prospective randomized trial in patients with aneurysmal subarachnoidhemorrhage?

Output: Comparison of rapid and gradual weaning fromexternal ventricular drainage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective randomized trial in patients with aneurysmal subarachnoidhemorrhage?. ### Response: Comparison of rapid and gradual weaning fromexternal ventricular drainage.


Instruction: What is a result of routine ventriculostomy withexternal ventricular drainage for acute hydrocephalus?

Output: weaning

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a result of routine ventriculostomy withexternal ventricular drainage for acute hydrocephalus?. ### Response: weaning.


Instruction: When did Acta Neurochir (Wien) publish?

Output: 1992

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Acta Neurochir (Wien) publish?. ### Response: 1992.


Instruction: What is the effect of external ven-tricular drainage in poor grade aneurysmal subarachnoid hem-orrhage on preoperative grading and prognosis?

Output: effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of external ven-tricular drainage in poor grade aneurysmal subarachnoid hem-orrhage on preoperative grading and prognosis?. ### Response: effect.


Instruction: What is Milhorat TH's title?

Output: Neurocrit Care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Milhorat TH's title?. ### Response: Neurocrit Care.


Instruction: What does the writingcommittee encourage development and implementa-tion of protocols for?

Output: antiplatelet and anticoagulant therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the writingcommittee encourage development and implementa-tion of protocols for?. ### Response: antiplatelet and anticoagulant therapy.


Instruction: What might occur in future iterations of this measure set as the evidence base evolves?

Output: reconsideration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What might occur in future iterations of this measure set as the evidence base evolves?. ### Response: reconsideration.


Instruction: How many iterations of this measure setas the evidence base evolves?

Output: future iterations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many iterations of this measure setas the evidence base evolves?. ### Response: future iterations.


Instruction: Nallamothu et al.February 25, 2014:722 –45 ACC/AHA/SCAI/AMA-PCPI/NCQA 2013 PCI Performance Measure735

Output: JACC Vol. 63, No. 7, 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Nallamothu et al.February 25, 2014:722 –45 ACC/AHA/SCAI/AMA-PCPI/NCQA 2013 PCI Performance Measure735. ### Response: JACC Vol. 63, No. 7, 2014.


Instruction: How is diastolic function normalized to age, gender and body surface area from steady-state free precession cardiovascular magnetic resonance?

Output: 27:2879–88

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is diastolic function normalized to age, gender and body surface area from steady-state free precession cardiovascular magnetic resonance?. ### Response: 27:2879–88.


Instruction: What year did Eur Heart J.27:2879-88.

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Eur Heart J.27:2879-88.. ### Response: 2006.


Instruction: What is Moderate tricuspid regurgitation with left-sided degenerative heart valve disease?

Output: to repair or not to repair

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Moderate tricuspid regurgitation with left-sided degenerative heart valve disease?. ### Response: to repair or not to repair.


Instruction: What is the name of the study that compares three-dimensional echocardiography with magnetic resonance imaging and radionuclide ventriculography?

Output: Echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that compares three-dimensional echocardiography with magnetic resonance imaging and radionuclide ventriculography?. ### Response: Echocardiography.


Instruction: How many patients were compared to magnetic resonance imagers in 2006?

Output: 42

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were compared to magnetic resonance imagers in 2006?. ### Response: 42.


Instruction: What did Nesser HJ, Tkalec W, Patel AR, et al. use to compare right ventricular volumes and ejection fraction?

Output: MRI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Nesser HJ, Tkalec W, Patel AR, et al. use to compare right ventricular volumes and ejection fraction?. ### Response: MRI.


Instruction: What is the rank of echocardiographic methods vs. cardiac magnetic resonance imaging?

Output: Right ventricular systolic function assess-ment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the rank of echocardiographic methods vs. cardiac magnetic resonance imaging?. ### Response: Right ventricular systolic function assess-ment.


Instruction: How is tricuspid annular plane systolic excursion assessed using MRI?

Output: semi-quantification of right ventricular ejection fraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is tricuspid annular plane systolic excursion assessed using MRI?. ### Response: semi-quantification of right ventricular ejection fraction.


Instruction: What was assessed using MRI for semi-quantification of right ventricular ejection fraction?

Output: Tricuspid annular plane systolic excursion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was assessed using MRI for semi-quantification of right ventricular ejection fraction?. ### Response: Tricuspid annular plane systolic excursion.


Instruction: What did Magne J, Girerd N, Sénéchal M, et al. compare for ischemic mitral regurgitation: comparison of short-term and long-term survival?

Output: Mitral repair versus replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Magne J, Girerd N, Sénéchal M, et al. compare for ischemic mitral regurgitation: comparison of short-term and long-term survival?. ### Response: Mitral repair versus replacement.


Instruction: What year was Kidney International founded?

Output: 2021

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was Kidney International founded?. ### Response: 2021.


Instruction: What is the name of the organization that was founded in 2021?

Output: Kidney International

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that was founded in 2021?. ### Response: Kidney International.


Instruction: How many strokes were there in May 2014?

Output: 1572

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes were there in May 2014?. ### Response: 1572.


Instruction: Why did women seem to have less benefit from surgery than men?

Output: increased risk of perioperative events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why did women seem to have less benefit from surgery than men?. ### Response: increased risk of perioperative events.


Instruction: What was the reason for the data being inconclusive?

Output: small sample sizes within sex strata

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the reason for the data being inconclusive?. ### Response: small sample sizes within sex strata.


Instruction: Why were the data in the Asymptomatic Carotid Surgery Trial inconclusive?

Output: small sample sizes within sex strata and the post hoc nature of some of the analyses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why were the data in the Asymptomatic Carotid Surgery Trial inconclusive?. ### Response: small sample sizes within sex strata and the post hoc nature of some of the analyses.


Instruction: How many trials conducted a prespecified secondary analysis by sex group?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many trials conducted a prespecified secondary analysis by sex group?. ### Response: 1.


Instruction: What group did the results of the Asymptomatic Carotid Atherosclerosis Study be similar to?

Output: women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What group did the results of the Asymptomatic Carotid Atherosclerosis Study be similar to?. ### Response: women.


Instruction: What was the only study where the results were statistically significant?

Output: European Carotid Surgery Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the only study where the results were statistically significant?. ### Response: European Carotid Surgery Trial.


Instruction: What is CAS?

Output: Carotid artery stenting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CAS?. ### Response: Carotid artery stenting.


Instruction: What has emerged as an alternative strategy for the management of carotid stenosis?

Output: Carotid artery stenting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has emerged as an alternative strategy for the management of carotid stenosis?. ### Response: Carotid artery stenting.


Instruction: In a meta-analysis of 3 European trials, there was no interaction between sex and what?

Output: 120-day outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In a meta-analysis of 3 European trials, there was no interaction between sex and what?. ### Response: 120-day outcome.


Instruction: How long was the outcome of the CREST trial?

Output: 120-day

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the outcome of the CREST trial?. ### Response: 120-day.


Instruction: How many patients were assigned to CEA or CAS?

Output: 2502

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were assigned to CEA or CAS?. ### Response: 2502.


Instruction: What percentage of the subjects were women?

Output: 6.7%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the subjects were women?. ### Response: 6.7%.


Instruction: How many years after randomization for CAS were ipsilateral strokes found?

Output: 4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many years after randomization for CAS were ipsilateral strokes found?. ### Response: 4.


Instruction: How many periprocedural events were found in men?

Output: 4.3%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many periprocedural events were found in men?. ### Response: 4.3%.


Instruction: What was the difference between men and women?

Output: 8.9% versus 6.7%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the difference between men and women?. ### Response: 8.9% versus 6.7%.


Instruction: What was the 95% confidence interval between 0.82 and 2.23?

Output: 0.66–1.46

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 95% confidence interval between 0.82 and 2.23?. ### Response: 0.66–1.46.


Instruction: What percentage of men did periprocedural events occur in versus 6.8% of 455 women assigned to CAS?

Output: 4.3%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of men did periprocedural events occur in versus 6.8% of 455 women assigned to CAS?. ### Response: 4.3%.


Instruction: How many women did CAS-to-CEA treatment differences occur?

Output: Roughly 35%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many women did CAS-to-CEA treatment differences occur?. ### Response: Roughly 35%.


Instruction: How was the CAS-to-CEA treatment difference affected by age?

Output: (P =0.02

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the CAS-to-CEA treatment difference affected by age?. ### Response: (P =0.02.


Instruction: What did older patients do better with CEA?

Output: bet-ter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did older patients do better with CEA?. ### Response: bet-ter.


Instruction: How did younger patients fare better with CAS?

Output: women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did younger patients fare better with CAS?. ### Response: women.


Instruction: What was different for women than men?

Output: less benefit from surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was different for women than men?. ### Response: less benefit from surgery.


Instruction: Data from CREST suggest that women with CAS may be at higher risk for the composite outcome of stroke, death, or MI during what period?

Output: periprocedural period

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Data from CREST suggest that women with CAS may be at higher risk for the composite outcome of stroke, death, or MI during what period?. ### Response: periprocedural period.


Instruction: What is inter -preted with caution pending confirmation from other trials?

Output: CAS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is inter -preted with caution pending confirmation from other trials?. ### Response: CAS.


Instruction: What may not be enough data to conclude that high-grade symptomatic or asymptomatic carotid stenosis should be managed differently in men and women?

Output: small sample sizes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may not be enough data to conclude that high-grade symptomatic or asymptomatic carotid stenosis should be managed differently in men and women?. ### Response: small sample sizes.


Instruction: What should be applied to women without definitive data?

Output: the recommendations in the guidelines for prevention of first or recurrent stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be applied to women without definitive data?. ### Response: the recommendations in the guidelines for prevention of first or recurrent stroke.


Instruction: What is one of the seminal trials of primary prevention of CVD in women?

Output: WHS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the seminal trials of primary prevention of CVD in women?. ### Response: WHS.


Instruction: What is the name of a randomized trial of CVD, including stroke, in women?

Output: WHS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of a randomized trial of CVD, including stroke, in women?. ### Response: WHS.


Instruction: What may be used to comple-ment standardized of fice BP readings for the diagnosis andmanagement of high BP in the kidney transplant population?

Output: ABPM or HBPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be used to comple-ment standardized of fice BP readings for the diagnosis andmanagement of high BP in the kidney transplant population?. ### Response: ABPM or HBPM.


Instruction: What is often different from classi ficationusing standardized of fice BP in kidney transplant recipients?

Output: BP statususing out-of-of ﬁce BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is often different from classi ficationusing standardized of fice BP in kidney transplant recipients?. ### Response: BP statususing out-of-of ﬁce BP.


Instruction: What may the complementary use of out-of-fice BP measurements lead to more appropriate therapeutic decisions?

Output: kidney transplant recipients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may the complementary use of out-of-fice BP measurements lead to more appropriate therapeutic decisions?. ### Response: kidney transplant recipients.


Instruction: What is a dihy-dropyridine calcium channel blocker?

Output: CCB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a dihy-dropyridine calcium channel blocker?. ### Response: CCB.


Instruction: What should be used as the first-line antihypertensive agent?

Output: dihy-dropyridine calcium channel blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be used as the first-line antihypertensive agent?. ### Response: dihy-dropyridine calcium channel blocker.


Instruction: What should anARB be used as the first-line antihypertensive agentin adult kidney transplant recipients?

Output: dihy-dropyridine calcium channel blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should anARB be used as the first-line antihypertensive agentin adult kidney transplant recipients?. ### Response: dihy-dropyridine calcium channel blocker.


Instruction: What does the recommendation place a higher value on?

Output: pre-venting kidney allograft loss

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the recommendation place a higher value on?. ### Response: pre-venting kidney allograft loss.


Instruction: Why is the recommendation strong?

Output: the potential prevention of transplant failure outweighs potentialrisks of burden associated with its implementation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is the recommendation strong?. ### Response: the potential prevention of transplant failure outweighs potentialrisks of burden associated with its implementation.


Instruction: What outweighs the potential risks of burden associated with its implementation?

Output: the potential prevention of transplant failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What outweighs the potential risks of burden associated with its implementation?. ### Response: the potential prevention of transplant failure.


Instruction: The Work Group judged that all or nearly all well-informed transplantpatients would choose to receive what?

Output: a CCB or an ARB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The Work Group judged that all or nearly all well-informed transplantpatients would choose to receive what?. ### Response: a CCB or an ARB.


Instruction: What is an ARB given thepotential bene fit?

Output: CCB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an ARB given thepotential bene fit?. ### Response: CCB.


Instruction: What is the importance of preventing graft loss to?

Output: kidneytransplant recipients and clinicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the importance of preventing graft loss to?. ### Response: kidneytransplant recipients and clinicians.


Instruction: What is the name of the disease that causes heart failure?

Output: Chroni c Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease that causes heart failure?. ### Response: Chroni c Heart Failure.


Instruction: What does heart failure usually occur because?

Output: the heart has become too weak or stiff

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does heart failure usually occur because?. ### Response: the heart has become too weak or stiff.


Instruction: What causes heart failure?

Output: the heart has become too weak or stiff

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes heart failure?. ### Response: the heart has become too weak or stiff.


Instruction: Heart failure with preserved ejection fraction A form of congestive heart failure where the amount of blood pumped from the heart's left ventricle is greater?

Output: 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Heart failure with preserved ejection fraction A form of congestive heart failure where the amount of blood pumped from the heart's left ventricle is greater?. ### Response: 50%.


Instruction: What is the left ventricle with ea ch beat?

Output: ejection fraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the left ventricle with ea ch beat?. ### Response: ejection fraction.


Instruction: What is HFREF?

Output: The heart muscle is not able to contract adequately and, therefore, expels less oxygen -rich blood into the body

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is HFREF?. ### Response: The heart muscle is not able to contract adequately and, therefore, expels less oxygen -rich blood into the body.


Instruction: How does the heart muscle contract?

Output: not able to contract adequately

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does the heart muscle contract?. ### Response: not able to contract adequately.


Instruction: What is HBP?

Output: high blood pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is HBP?. ### Response: high blood pressure.


Instruction: What is a long-term medical condition in which the blood pressure in the arteries is persistently elevated?

Output: Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a long-term medical condition in which the blood pressure in the arteries is persistently elevated?. ### Response: Hypertension.


Instruction: Implantable Cardioverter Defibrillators Small devices to treat abnormal heart rhythms What happens when arteries are narrowed?

Output: less blood and oxygen reaches the heart muscle

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Implantable Cardioverter Defibrillators Small devices to treat abnormal heart rhythms What happens when arteries are narrowed?. ### Response: less blood and oxygen reaches the heart muscle.


Instruction: What are narrowed, less blood and oxygen reach the heart muscle?

Output: arteries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are narrowed, less blood and oxygen reach the heart muscle?. ### Response: arteries.


Instruction: What is also known as coronary artery disease?

Output: Ischemic heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is also known as coronary artery disease?. ### Response: Ischemic heart disease.


Instruction: How is pressure over the venous system observed?

Output: via visualization of the internal jugular vein

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is pressure over the venous system observed?. ### Response: via visualization of the internal jugular vein.


Instruction: What is myocardial infarction commonly known as?

Output: a heart attack

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is myocardial infarction commonly known as?. ### Response: a heart attack.


Instruction: What happens when blood flow decreases or stops to a part of the heart?

Output: damage to the heart muscle

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What happens when blood flow decreases or stops to a part of the heart?. ### Response: damage to the heart muscle.


Instruction: Natriuretic peptides Excretion of sodium by the kidneys what?

Output: N-terminus pro B type

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Natriuretic peptides Excretion of sodium by the kidneys what?. ### Response: N-terminus pro B type.


Instruction: What is a non-active prohormone that is released from the same molecule that produces BNP?

Output: N-terminus pro B type natriuretic peptide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a non-active prohormone that is released from the same molecule that produces BNP?. ### Response: N-terminus pro B type natriuretic peptide.


Instruction: Paroxysmal nocturnal dyspnoea Attacks of severe shortness of breath and coughing generally occur at night?

Output: B-type natriuretic peptide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Paroxysmal nocturnal dyspnoea Attacks of severe shortness of breath and coughing generally occur at night?. ### Response: B-type natriuretic peptide.


Instruction: What is stenosis of the coronary arteries of the heart found in?

Output: coronary artery disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is stenosis of the coronary arteries of the heart found in?. ### Response: coronary artery disease.


Instruction: What is the top number of your systolic blood pressure?

Output: Transferrin saturations  The value of serum iron divided by the total iron -binding capacity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the top number of your systolic blood pressure?. ### Response: Transferrin saturations  The value of serum iron divided by the total iron -binding capacity.


Instruction: What refers to the amount of pressure in your arteries during contraction of your heart muscle?

Output: Systolic Blood Pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What refers to the amount of pressure in your arteries during contraction of your heart muscle?. ### Response: Systolic Blood Pressure.


Instruction: Transferrin saturations The value of serum iron divided by what?

Output: the total iron -binding capacity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Transferrin saturations The value of serum iron divided by what?. ### Response: the total iron -binding capacity.


Instruction: Transient ischaemic attack A temporary disruption in the blood supply to what part of the brain?

Output: part of the brain

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Transient ischaemic attack A temporary disruption in the blood supply to what part of the brain?. ### Response: part of the brain.


Instruction: What does the blood supply to part of the brain do?

Output: disruption

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the blood supply to part of the brain do?. ### Response: disruption.


Instruction: What is a flow chart of the study?

Output: Algorithm (in guidelines)  A flow chart of the clinical decision pathway described in the guideline, where decision points are represented with boxes, linked with arrows

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a flow chart of the study?. ### Response: Algorithm (in guidelines)  A flow chart of the clinical decision pathway described in the guideline, where decision points are represented with boxes, linked with arrows.


Instruction: What is a flow chart of the clinical decision pathway described in a guideline?

Output: Algorithm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a flow chart of the clinical decision pathway described in a guideline?. ### Response: Algorithm.


Instruction: Decision points are represented with boxes, linked with what?

Output: arrows

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Decision points are represented with boxes, linked with what?. ### Response: arrows.


Instruction: What is the process used to prevent advance knowledge of group assignment in an RCT?

Output: Allocation concealment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the process used to prevent advance knowledge of group assignment in an RCT?. ### Response: Allocation concealment.


Instruction: What should be impervious to any influence by the individual making the allocation?

Output: The allocation process

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be impervious to any influence by the individual making the allocation?. ### Response: The allocation process.


Instruction: Who should be administered by someone who is not responsible for recruiting participants?

Output: The allocation process

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should be administered by someone who is not responsible for recruiting participants?. ### Response: The allocation process.


Instruction: What can the results of a study or NICE evidence review answer?

Output: a clinical question

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can the results of a study or NICE evidence review answer?. ### Response: a clinical question.


Instruction: What type of review can answer a clinical question?

Output: study or NICE evidence review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of review can answer a clinical question?. ### Response: study or NICE evidence review.


Instruction: What can be applied to the population being considered?

Output: results of a study or NICE evidence review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be applied to the population being considered?. ### Response: results of a study or NICE evidence review.


Instruction: What may be reasonable to consider as a communication strategy for reinforcing adher ence to lifestyle recommendations?

Output: short-term risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be reasonable to consider as a communication strategy for reinforcing adher ence to lifestyle recommendations?. ### Response: short-term risk.


Instruction: What are LIFESTYLE FACTORS AFFECTING CARDIOVASCULAR RISK?

Output: S2.2-23

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are LIFESTYLE FACTORS AFFECTING CARDIOVASCULAR RISK?. ### Response: S2.2-23.


Instruction: What is a diet that emphasizes intake of vegetables, fruits, legumes, nuts, and whole grains recommended to decrease?

Output: ASCVD risk factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a diet that emphasizes intake of vegetables, fruits, legumes, nuts, and whole grains recommended to decrease?. ### Response: ASCVD risk factors.


Instruction: What can be beneficial to reduce ASCVD risk?

Output: Healthy nutrition

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be beneficial to reduce ASCVD risk?. ### Response: Healthy nutrition.


Instruction: What can a diet containing reduced amounts of cholesterol and sodium do?

Output: beneficial to decrease ASCVD risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can a diet containing reduced amounts of cholesterol and sodium do?. ### Response: beneficial to decrease ASCVD risk.


Instruction: What should be avoided as part of a healthy diet to reduce ASCVD risk?

Output: trans fats

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be avoided as part of a healthy diet to reduce ASCVD risk?. ### Response: trans fats.


Instruction: How many Americans died from heart dis-ease in 2015?

Output: 630 000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many Americans died from heart dis-ease in 2015?. ### Response: 630 000.


Instruction: How many people died from coronary ar tery disease in 2015?

Output: 366 000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people died from coronary ar tery disease in 2015?. ### Response: 366 000.


Instruction: What was the cause of the increase in heart disease deaths?

Output: coronary ar -tery disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the cause of the increase in heart disease deaths?. ### Response: coronary ar -tery disease.


Instruction: How long did the decline of heart disease last?

Output: 4 decades

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the decline of heart disease last?. ### Response: 4 decades.


Instruction: The obesity epidemic has been attributed to what?

Output: Healthy nutrition

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The obesity epidemic has been attributed to what?. ### Response: Healthy nutrition.


Instruction: What is limited by the paucity of large-scale prospective randomized trials with ASCVD outcomes?

Output: The cardiovascular nutri-tion literature

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is limited by the paucity of large-scale prospective randomized trials with ASCVD outcomes?. ### Response: The cardiovascular nutri-tion literature.


Instruction: What are RCTs focused on?

Output: hard endpoints

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are RCTs focused on?. ### Response: hard endpoints.


Instruction: How many studies have focused on the association of CVD mortality with dietary patterns?

Output: multiple

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies have focused on the association of CVD mortality with dietary patterns?. ### Response: multiple.


Instruction: What are some examples of processed red meat?

Output: bacon, salami, ham, hot dogs, sausage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some examples of processed red meat?. ### Response: bacon, salami, ham, hot dogs, sausage.


Instruction: What are red meats?

Output: pro-cessed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are red meats?. ### Response: pro-cessed.


Instruction: What are processed meats pre-served by smoking, curing, or salting?

Output: S3.1-1–S3.1-24 Processed meats are any meat pre-served by smoking, curing, or salting, or additional chemical preservatives

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are processed meats pre-served by smoking, curing, or salting?. ### Response: S3.1-1–S3.1-24 Processed meats are any meat pre-served by smoking, curing, or salting, or additional chemical preservatives.


Instruction: What type of protein con-sumption is preferable?

Output: fish

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of protein con-sumption is preferable?. ### Response: fish.


Instruction: What is ahajournals.org about?

Output: http://ahajournals.org by on May 1, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ahajournals.org about?. ### Response: http://ahajournals.org by on May 1, 2023.


Instruction: When will the paper be available for download?

Output: May 1, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When will the paper be available for download?. ### Response: May 1, 2023.


Instruction: What is the most common cause of isch-emic stroke?

Output: primary cardiac tumors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common cause of isch-emic stroke?. ### Response: primary cardiac tumors.


Instruction: What type of tumor is most likely to cause embolilic stroke? What is a primary malignant cardiac neoplasm?

Output: sarcomas

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of tumor is most likely to cause embolilic stroke? What is a primary malignant cardiac neoplasm?. ### Response: sarcomas.


Instruction: Is myxoma or sarcoma common?

Output: Myxoma is the most common cardiac tumor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Is myxoma or sarcoma common?. ### Response: Myxoma is the most common cardiac tumor.


Instruction: What are intracavitary tumors that have friable surfaces called?

Output: Cardiac Tumors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are intracavitary tumors that have friable surfaces called?. ### Response: Cardiac Tumors.


Instruction: What is the most common cardiac tumor?

Output: Myxoma

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common cardiac tumor?. ### Response: Myxoma.


Instruction: Where do the majority of myxomas occur?

Output: left atrium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where do the majority of myxomas occur?. ### Response: left atrium.


Instruction: How many patients with papillary fibroelastomas have TIA?

Output: half

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with papillary fibroelastomas have TIA?. ### Response: half.


Instruction: What is recommended for patients with papillary fibroelastomas?

Output: Surgical interven-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for patients with papillary fibroelastomas?. ### Response: Surgical interven-tion.


Instruction: What is a risk of embolism?

Output: fibro-elastomas

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk of embolism?. ### Response: fibro-elastomas.


Instruction: Surgical exci-sion of atrial myxomas is what?

Output: recommended

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Surgical exci-sion of atrial myxomas is what?. ### Response: recommended.


Instruction: Why do neoplasms pose a risk for embolism?

Output: cardiac surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why do neoplasms pose a risk for embolism?. ### Response: cardiac surgery.


Instruction: What depend on the precise nature and extent of the tumor?

Output: Recommendations for the treatment of malignant cardiac neo-plasms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What depend on the precise nature and extent of the tumor?. ### Response: Recommendations for the treatment of malignant cardiac neo-plasms.


Instruction: Large, complex plaques have an increased risk of what?

Output: cryptogenic strokes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Large, complex plaques have an increased risk of what?. ### Response: cryptogenic strokes.


Instruction: What is associated with an increased risk of cryptogenic strokes?

Output: Plaques ≥4 mm in size

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with an increased risk of cryptogenic strokes?. ### Response: Plaques ≥4 mm in size.


Instruction: What was found to be independent predictors of recurrent stroke?

Output: plaques >4 mm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was found to be independent predictors of recurrent stroke?. ### Response: plaques >4 mm.


Instruction: Who participated in PICSS?

Output: patients with crypto-genic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who participated in PICSS?. ### Response: patients with crypto-genic stroke.


Instruction: Large plaques detected by transesophageal echocardiography were associated with an increased risk of recurrent ischemic stroke or death over a 2-year follow-up?

Output: patients with crypto-genic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Large plaques detected by transesophageal echocardiography were associated with an increased risk of recurrent ischemic stroke or death over a 2-year follow-up?. ### Response: patients with crypto-genic stroke.


Instruction: Atheroembolism from aortic plaques is also a cause of stroke associated with what?

Output: cardiac surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atheroembolism from aortic plaques is also a cause of stroke associated with what?. ### Response: cardiac surgery.


Instruction: There are no prospec-tive, randomized trials examining the efficacy of what to reduce the risk of stroke caused by embolic events?

Output: medical ther -apy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There are no prospec-tive, randomized trials examining the efficacy of what to reduce the risk of stroke caused by embolic events?. ### Response: medical ther -apy.


Instruction: What did warfarin reduce the risk of in patients with mobile thoracic atheroma detected by transesophageal echo-cardiography?

Output: recurrent stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did warfarin reduce the risk of in patients with mobile thoracic atheroma detected by transesophageal echo-cardiography?. ### Response: recurrent stroke.


Instruction: What did patients with aortic plaques >4 mm thick treated with oral anticoagulants have fewer stroke and peripheral embolic events?

Output: antiplatelet therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did patients with aortic plaques >4 mm thick treated with oral anticoagulants have fewer stroke and peripheral embolic events?. ### Response: antiplatelet therapy.


Instruction: Who had fewer stroke and peripheral embolic events than those treated with antiplatelet therapy?

Output: patients with aortic plaques >4 mm thick treated with oral anticoagulants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who had fewer stroke and peripheral embolic events than those treated with antiplatelet therapy?. ### Response: patients with aortic plaques >4 mm thick treated with oral anticoagulants.


Instruction: What was the OR of statin therapy in a retrospective analysis of patients with severe thoracic aortic plaque?

Output: 0.3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the OR of statin therapy in a retrospective analysis of patients with severe thoracic aortic plaque?. ### Response: 0.3.


Instruction: What did antiplatelet therapy reduce the risk of stroke, TIA, and peripheral emboli?

Output: 510 A retrospective analysis of patients with severe thoracic aortic plaque found that statin therapy (OR, 0.3; 95% CI, 0.2–0.6), but not warfarin (OR, 0.7; 95% CI, 0.4–1.2) or antiplatelet therapy (OR, 1.4; 95% CI, 0.8–2.4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did antiplatelet therapy reduce the risk of stroke, TIA, and peripheral emboli?. ### Response: 510 A retrospective analysis of patients with severe thoracic aortic plaque found that statin therapy (OR, 0.3; 95% CI, 0.2–0.6), but not warfarin (OR, 0.7; 95% CI, 0.4–1.2) or antiplatelet therapy (OR, 1.4; 95% CI, 0.8–2.4.


Instruction: What is the 95% CI?

Output: 1.62–25.46

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 95% CI?. ### Response: 1.62–25.46.


Instruction: What type of heart disease had the highest risk?

Output: complex congenital

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of heart disease had the highest risk?. ### Response: complex congenital.


Instruction: What are the mech-anisms underlying an increased risk of stroke related to?

Output: high prevalence of atrial arrhythmias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the mech-anisms underlying an increased risk of stroke related to?. ### Response: high prevalence of atrial arrhythmias.


Instruction: What causes atrial mechanical dysfunction?

Output: the presence of scar

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes atrial mechanical dysfunction?. ### Response: the presence of scar.


Instruction: What causes associated hyperviscosity/hypercoagulability?

Output: chronic hypoxemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes associated hyperviscosity/hypercoagulability?. ### Response: chronic hypoxemia.


Instruction: In patients with cyanotic and other complex congenital heart disease and isch-emic stroke, what is reasonable?

Output: treatment with warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with cyanotic and other complex congenital heart disease and isch-emic stroke, what is reasonable?. ### Response: treatment with warfarin.


Instruction: What is reasonable in the absence of contraindications to oral anticoagula-tion?

Output: treatment with warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable in the absence of contraindications to oral anticoagula-tion?. ### Response: treatment with warfarin.


Instruction: What is increased risk of bleeding?

Output: oral anticoagula-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is increased risk of bleeding?. ### Response: oral anticoagula-tion.


Instruction: A subset of patients with Fontan palliative surgery have a fenestration between the Fontan path-way and what?

Output: the pulmonary venous atrium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A subset of patients with Fontan palliative surgery have a fenestration between the Fontan path-way and what?. ### Response: the pulmonary venous atrium.


Instruction: What is Fontan hypertension?

Output: systemic venous

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Fontan hypertension?. ### Response: systemic venous.


Instruction: What can cause stroke and thromboembolism?

Output: Right-to-left shunt from a fenestration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can cause stroke and thromboembolism?. ### Response: Right-to-left shunt from a fenestration.


Instruction: What has been performed in some patients with a patent fenestration presenting with stroke?

Output: Catheter closure of Fontan fenestration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been performed in some patients with a patent fenestration presenting with stroke?. ### Response: Catheter closure of Fontan fenestration.


Instruction: What is needed to determine whether this approach is of real incremental benefit to prevent ischemic stroke or TIA compared with oral antico-agulation therapy alone?

Output: more data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed to determine whether this approach is of real incremental benefit to prevent ischemic stroke or TIA compared with oral antico-agulation therapy alone?. ### Response: more data.


Instruction: DOACs have been demonstrated to be what?

Output: noninferior or superior to dose-adjusted warfarin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: DOACs have been demonstrated to be what?. ### Response: noninferior or superior to dose-adjusted warfarin therapy.


Instruction: DoACs have been shown to be superior or noninferior to dose-adjusted warfarin therapy?

Output: noninferior or superior

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: DoACs have been shown to be superior or noninferior to dose-adjusted warfarin therapy?. ### Response: noninferior or superior.


Instruction: DoAC therapy has rapidly become the standard of care for patients with nonvalvular AF?

Output: DOACs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: DoAC therapy has rapidly become the standard of care for patients with nonvalvular AF?. ### Response: DOACs.


Instruction: What are important advantages of DOAC therapy compared with war-farin?

Output: a more predictable pharmacokinetic profile requiring no monitoring, fewer interactions with other drugs, and a rapid onset/offset of action

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are important advantages of DOAC therapy compared with war-farin?. ### Response: a more predictable pharmacokinetic profile requiring no monitoring, fewer interactions with other drugs, and a rapid onset/offset of action.


Instruction: DoAC therapy has a more predictable pharmacokinetic profile than what other drug?

Output: war-farin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: DoAC therapy has a more predictable pharmacokinetic profile than what other drug?. ### Response: war-farin.


Instruction: DoACs have fewer interactions with other drugs and a rapid onset/offset of what?

Output: action

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: DoACs have fewer interactions with other drugs and a rapid onset/offset of what?. ### Response: action.


Instruction: What does DOAC therapy prevent in patients with congenital heart disease?

Output: recurrent thromboembolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does DOAC therapy prevent in patients with congenital heart disease?. ### Response: recurrent thromboembolism.


Instruction: Patients with congenital heart disease and history of isch-emic stroke or TIA are limited to what?

Output: small observational series

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with congenital heart disease and history of isch-emic stroke or TIA are limited to what?. ### Response: small observational series.