Instruction: What is a non pharmacological treatment for hyperlipidemia?

Output: cost

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a non pharmacological treatment for hyperlipidemia?. ### Response: cost.


Instruction: What is another name for hypertriglyceridaemia?

Output: hyperlipoproteinaemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for hypertriglyceridaemia?. ### Response: hyperlipoproteinaemia.


Instruction: What is a CV risk?

Output: cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a CV risk?. ### Response: cardiovascular disease.


Instruction: WHAT is another word for hyperlipemi?

Output: hyperlipaemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: WHAT is another word for hyperlipemi?. ### Response: hyperlipaemia.


Instruction: What is 'cardiovascular disease'/exp/mj OR 'heart disease'?

Output: hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is 'cardiovascular disease'/exp/mj OR 'heart disease'?. ### Response: hypertension.


Instruction: What is an example of a heart infarction?

Output: cerebrovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a heart infarction?. ### Response: cerebrovascular disease.


Instruction: What is another name for heart NEXT/1 attack?

Output: myocardial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for heart NEXT/1 attack?. ### Response: myocardial.


Instruction: What is the other name for stroke?

Output: stroke*

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the other name for stroke?. ### Response: stroke*.


Instruction: Infarct*) OR stroke*):ti) OR (risk* OR prevent*)?

Output: cerebrovascular NEXT/1 accident*)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Infarct*) OR stroke*):ti) OR (risk* OR prevent*)?. ### Response: cerebrovascular NEXT/1 accident*).


Instruction: Dietary supplements/ neutraceuticals 'dietary supplement'/exp OR 'vitamin'/de OR garlic/expan OR phytosterol'/extpan OR ((diet OR dietary) NEAR/5 supplement*)

Output: ):ti  #3 Dietary supplements/ neutraceuticals  'dietary supplement'/exp OR 'plant medicinal product

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Dietary supplements/ neutraceuticals 'dietary supplement'/exp OR 'vitamin'/de OR garlic/expan OR phytosterol'/extpan OR ((diet OR dietary) NEAR/5 supplement*). ### Response: ):ti  #3 Dietary supplements/ neutraceuticals  'dietary supplement'/exp OR 'plant medicinal product.


Instruction: What is 'ispagula' or 'tea'/exp OR ((diet OR dietary) NEAR/5 supplement*) OR neutraceutical* OR (omega* OR marine) NEXT/3 fatty) OR "fish oil" OR "icosapent ethyl" OR ( (diet* OR soluable)NEAR/5 fiber) OR garlic OR ginger OR phytosterol?

Output: phytosterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is 'ispagula' or 'tea'/exp OR ((diet OR dietary) NEAR/5 supplement*) OR neutraceutical* OR (omega* OR marine) NEXT/3 fatty) OR "fish oil" OR "icosapent ethyl" OR ( (diet* OR soluable)NEAR/5 fiber) OR garlic OR ginger OR phytosterol?. ### Response: phytosterol.


Instruction: What is the name of the plant NEXT/2 sterol*?

Output: phytosterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the plant NEXT/2 sterol*?. ### Response: phytosterol.


Instruction: What is niacin* OR psyllium?

Output: docosahexaenoic) NEXT/1 acid*) OR “icosapent ethyl” OR ((diet* OR soluable) NEAR/5 fiber) OR garlic OR ginger OR phytosterol*

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is niacin* OR psyllium?. ### Response: docosahexaenoic) NEXT/1 acid*) OR “icosapent ethyl” OR ((diet* OR soluable) NEAR/5 fiber) OR garlic OR ginger OR phytosterol*.


Instruction: What type of diet is ti or "diabetic diet"?

Output: dietary next/1 approach* NEXT/1 stop NEXT/1 hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diet is ti or "diabetic diet"?. ### Response: dietary next/1 approach* NEXT/1 stop NEXT/1 hypertension.


Instruction: What is the name of the exercise/exp OR?

Output: aerobics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the exercise/exp OR?. ### Response: aerobics.


Instruction: What type of training does tai chi stand for?

Output: strength

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of training does tai chi stand for?. ### Response: strength.


Instruction: What kind of training is plyometric training?

Output: resistance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What kind of training is plyometric training?. ### Response: resistance.


Instruction: OR yoga OR swimming OR running OR "weight training"):ti #6 Outcomes of what?

Output: Exercise  'exercise'/exp OR (aerobics OR dance OR dancing OR exercise* OR fitness OR kinesiotherapy OR "muscle strengthening" OR "physical activity" OR "physical conditioning" OR "plyometric training" OR "resistance training" OR "strength training" OR "tai chi" OR "tai -chi" OR walk* OR "weight lifting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: OR yoga OR swimming OR running OR "weight training"):ti #6 Outcomes of what?. ### Response: Exercise  'exercise'/exp OR (aerobics OR dance OR dancing OR exercise* OR fitness OR kinesiotherapy OR "muscle strengthening" OR "physical activity" OR "physical conditioning" OR "plyometric training" OR "resistance training" OR "strength training" OR "tai chi" OR "tai -chi" OR walk* OR "weight lifting.


Instruction: How does the CDU use performance and quality measures to improve quality of care for patients with HBPMeasure Components?

Output: evaluation and improvement in clinical settings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does the CDU use performance and quality measures to improve quality of care for patients with HBPMeasure Components?. ### Response: evaluation and improvement in clinical settings.


Instruction: What is the DOI of the 2019 AHA/ACC High Blood Pressure Performance and Quality MeasuresCirc Cardiovasc Qual Outcomes.?

Output: 12:e000057

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the DOI of the 2019 AHA/ACC High Blood Pressure Performance and Quality MeasuresCirc Cardiovasc Qual Outcomes.?. ### Response: 12:e000057.


Instruction: What does the CDU use for evaluation and improvement in clinical settings for the diagnosis and management of patients with HBP?

Output: performance and quality measures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the CDU use for evaluation and improvement in clinical settings for the diagnosis and management of patients with HBP?. ### Response: performance and quality measures.


Instruction: What are performance measures developed according to?

Output: established ACC/AHA standards

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are performance measures developed according to?. ### Response: established ACC/AHA standards.


Instruction: ACC/AHA standards identify key structural components, care processes, and outcomes that are highly correlated with what?

Output: important, high-priority patient care goals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ACC/AHA standards identify key structural components, care processes, and outcomes that are highly correlated with what?. ### Response: important, high-priority patient care goals.


Instruction: Methods to accurately and feasibly collect data in order to assess performance measures?

Output: electronic health records, national data registries, administrative databases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Methods to accurately and feasibly collect data in order to assess performance measures?. ### Response: electronic health records, national data registries, administrative databases.


Instruction: What is the purpose of performance measures?

Output: associated with meaningful, desirable patient outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of performance measures?. ### Response: associated with meaningful, desirable patient outcomes.


Instruction: What are performance measures aimed at?

Output: identifying and improving suboptimal medical care and patient outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are performance measures aimed at?. ### Response: identifying and improving suboptimal medical care and patient outcomes.


Instruction: What is one of several potential strategies that can be used to help reduce gaps in the quality of health care?

Output: Performance measures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of several potential strategies that can be used to help reduce gaps in the quality of health care?. ### Response: Performance measures.


Instruction: What are effective performance measures associated with?

Output: meaningful, desirable patient outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are effective performance measures associated with?. ### Response: meaningful, desirable patient outcomes.


Instruction: What should be included in a performance measure design?

Output: patient groups, healthcare providers, and/or observation periods

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be included in a performance measure design?. ### Response: patient groups, healthcare providers, and/or observation periods.


Instruction: What should the components of the performance measure be?

Output: precise, validated components that are feasible, actionable, and meaningful

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should the components of the performance measure be?. ### Response: precise, validated components that are feasible, actionable, and meaningful.


Instruction: What do performance measures usually reflect?

Output: clinical practice guidelines of the highest levels of recommendation and evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do performance measures usually reflect?. ### Response: clinical practice guidelines of the highest levels of recommendation and evidence.


Instruction: What are the highest levels of recommendation and evidence?

Output: clinical practice guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the highest levels of recommendation and evidence?. ### Response: clinical practice guidelines.


Instruction: How can performance measures help improve gaps in care?

Output: use of effective performance measures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can performance measures help improve gaps in care?. ### Response: use of effective performance measures.


Instruction: How many studies have been published on HBP performance measures?

Output: No RCTs of HBP performance measures have been published

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies have been published on HBP performance measures?. ### Response: No RCTs of HBP performance measures have been published.


Instruction: What are the performance measures for hypertension that meet established ACC/AHA standards?

Output: Performance Measures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the performance measures for hypertension that meet established ACC/AHA standards?. ### Response: Performance Measures.


Instruction: What are the key components that influence the impact and sustainability of hypertension detection, treatment, and control for the target population?

Output: medical care, cost of care, patient-reported factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the key components that influence the impact and sustainability of hypertension detection, treatment, and control for the target population?. ### Response: medical care, cost of care, patient-reported factors.


Instruction: What do you help address the most pressing gaps in hypertension related care for the healthcare provider, practice, or system?

Output: Performance measures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do you help address the most pressing gaps in hypertension related care for the healthcare provider, practice, or system?. ### Response: Performance measures.


Instruction: What is the most feasible and meaningful way to collect performance measures data?

Output: actionable

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most feasible and meaningful way to collect performance measures data?. ### Response: actionable.


Instruction: What are some examples of available data sources?

Output: electronic health records, national data registries, administrative databases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some examples of available data sources?. ### Response: electronic health records, national data registries, administrative databases.


Instruction: What is the name of the meta-analysis of effects on lipids and haemostatic factors?

Output: Moderate alcohol intake

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis of effects on lipids and haemostatic factors?. ### Response: Moderate alcohol intake.


Instruction: What does Mukamal KJ say about alcohol and lower risk of coronary heart disease?

Output: Understanding the mechanisms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Mukamal KJ say about alcohol and lower risk of coronary heart disease?. ### Response: Understanding the mechanisms.


Instruction: What is the risk of coronary heart disease?

Output: lower risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of coronary heart disease?. ### Response: lower risk.


Instruction: What is a common sense and scientific truth?

Output: Alcohol and cardiovascular mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a common sense and scientific truth?. ### Response: Alcohol and cardiovascular mortality.


Instruction: When did alcohol consumption and cardiovascular mortality among U.S. adults occur?

Output: 1987 to 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did alcohol consumption and cardiovascular mortality among U.S. adults occur?. ### Response: 1987 to 2002.


Instruction: What was the median age of adults in the U.S. from 1987 to 2002?

Output: 1987

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the median age of adults in the U.S. from 1987 to 2002?. ### Response: 1987.


Instruction: What did the J Am Coll Cardiol. 2010 say about patients?

Output: Patient Evaluation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the J Am Coll Cardiol. 2010 say about patients?. ### Response: Patient Evaluation.


Instruction: How was the prevalence of hyperkalemia in a large health system assessed?

Output: Antihypertensive medications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the prevalence of hyperkalemia in a large health system assessed?. ### Response: Antihypertensive medications.


Instruction: What type of organ damage is caused by hypertension?

Output: Cardiovascular Target Organ Damage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of organ damage is caused by hypertension?. ### Response: Cardiovascular Target Organ Damage.


Instruction: What is the blood pressure trajectories in early adulthood and subclinical atherosclerosis in middle age?

Output: Blood pressure trajectories in early adulthood and subclinical atherosclerosis in middle age. JAMA. 2014;311:490–7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the blood pressure trajectories in early adulthood and subclinical atherosclerosis in middle age?. ### Response: Blood pressure trajectories in early adulthood and subclinical atherosclerosis in middle age. JAMA. 2014;311:490–7.


Instruction: In what age group does atherosclerosis occur?

Output: middle

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what age group does atherosclerosis occur?. ### Response: middle.


Instruction: In what year did JAMA publish 311:490–7?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did JAMA publish 311:490–7?. ### Response: 2014.


Instruction: What is the association between prehypertension during young adulthood and coronary calcium later in life?

Output: Pletcher MJ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association between prehypertension during young adulthood and coronary calcium later in life?. ### Response: Pletcher MJ.


Instruction: What does the International Childhood Cardiovascular Cohort Consortium do?

Output: Combined effects of child and adult elevated blood pressure on subclinical atherosclero-sis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the International Childhood Cardiovascular Cohort Consortium do?. ### Response: Combined effects of child and adult elevated blood pressure on subclinical atherosclero-sis.


Instruction: What is the name of the consortium that studies the combined effects of child and adult elevated blood pressure on subclinical atherosclero-sis?

Output: International Childhood Cardiovascular Cohort Consortium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the consortium that studies the combined effects of child and adult elevated blood pressure on subclinical atherosclero-sis?. ### Response: International Childhood Cardiovascular Cohort Consortium.


Instruction: What is left ventricular hypertrophy in hypertension?

Output: stimuli, patterns, and consequences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is left ventricular hypertrophy in hypertension?. ### Response: stimuli, patterns, and consequences.


Instruction: What is the name of the Coronary Artery Risk Development in Young Adults Study?

Output: CARDIA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Coronary Artery Risk Development in Young Adults Study?. ### Response: CARDIA.


Instruction: What was the name of the Young Adults study?

Output: Coronary Artery Risk Development in Young Adults (CARDIA) Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the Young Adults study?. ### Response: Coronary Artery Risk Development in Young Adults (CARDIA) Study.


Instruction: What was Circ Cardiovasc Imaging's 2013 report?

Output: 6:769–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was Circ Cardiovasc Imaging's 2013 report?. ### Response: 6:769–.


Instruction: Who was the study's lead author?

Output: Persu A, De Plaen J-F

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the study's lead author?. ### Response: Persu A, De Plaen J-F.


Instruction: How did Fox ER, Musani SK, Samdarshi TE, et al. compare left ventricular mass in a community-based cohort of African Americans?

Output: Clinical correlates and prognostic significance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Fox ER, Musani SK, Samdarshi TE, et al. compare left ventricular mass in a community-based cohort of African Americans?. ### Response: Clinical correlates and prognostic significance.


Instruction: What did Liebson PR, Grandits GA, Dianzumba S, et al. compare of five antihypertensive monotherapies?

Output: placebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Liebson PR, Grandits GA, Dianzumba S, et al. compare of five antihypertensive monotherapies?. ### Response: placebo.


Instruction: What was the longitudinal tracking of left ventricular mass over the adult life course?

Output: clinical correlates of short- and long-term change in the framingham offspring study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the longitudinal tracking of left ventricular mass over the adult life course?. ### Response: clinical correlates of short- and long-term change in the framingham offspring study.


Instruction: How many antihypertensive monotherapies were compared with placebo for change in left ven-tricular mass in patients receiving nutritional-hygienic therapy in the Treatment of Mild Hypertension Study (TOMHS)?

Output: five

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many antihypertensive monotherapies were compared with placebo for change in left ven-tricular mass in patients receiving nutritional-hygienic therapy in the Treatment of Mild Hypertension Study (TOMHS)?. ### Response: five.


Instruction: When was the TOMHS study published?

Output: 1995

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the TOMHS study published?. ### Response: 1995.


Instruction: What could be achieved during cardiac rehabilitation?

Output: Cardiomyopathy Questionnaire

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could be achieved during cardiac rehabilitation?. ### Response: Cardiomyopathy Questionnaire.


Instruction: What should be used to improve patient-reported outcomes, reduce hospitaliza-tions and improve aerobic fitness?

Output: cardiac rehabilitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be used to improve patient-reported outcomes, reduce hospitaliza-tions and improve aerobic fitness?. ### Response: cardiac rehabilitation.


Instruction: What will help patients and the healthcareteam reach the best treatmen t plan for the individualpatient?

Output: Shareddecision-making

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will help patients and the healthcareteam reach the best treatmen t plan for the individualpatient?. ### Response: Shareddecision-making.


Instruction: What is critical to team-based care?

Output: optimizingGDMT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is critical to team-based care?. ### Response: optimizingGDMT.


Instruction: What is critical to optimizingGDMT?

Output: Team-based care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is critical to optimizingGDMT?. ### Response: Team-based care.


Instruction: What are some examples of team-based care?

Output: frequent follow-up visits, tele-health visits, and remote monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some examples of team-based care?. ### Response: frequent follow-up visits, tele-health visits, and remote monitoring.


Instruction: How does team management facilitate serial assessments?

Output: simultaneously.Patients with HF, particularly older patients,frequently have other CV and non-CV comorbidities thataffect their prognosis. The presence of multiple chronicconditions is associated with increased symptom burden,may contribute to progression of underlying disease, andoften plays a role in a large proportion of hospitalizationsin patients with HF. Further more, these comorbid con-ditions can greatly affect the treatment of HF and theability to optimize therapies. To optimally manage thesepatients and improve clinical outcomes, clinicians mustincreasingly consider diagno sis and treatment of relevantcomorbidities alongside the use of evidence-based HFtherapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does team management facilitate serial assessments?. ### Response: simultaneously.Patients with HF, particularly older patients,frequently have other CV and non-CV comorbidities thataffect their prognosis. The presence of multiple chronicconditions is associated with increased symptom burden,may contribute to progression of underlying disease, andoften plays a role in a large proportion of hospitalizationsin patients with HF. Further more, these comorbid con-ditions can greatly affect the treatment of HF and theability to optimize therapies. To optimally manage thesepatients and improve clinical outcomes, clinicians mustincreasingly consider diagno sis and treatment of relevantcomorbidities alongside the use of evidence-based HFtherapies.


Instruction: What is a bidirectional relationship be-tween HF and certain comorbidities?

Output: the pres-ence of one may increase the risk of the other

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a bidirectional relationship be-tween HF and certain comorbidities?. ### Response: the pres-ence of one may increase the risk of the other.


Instruction: What can increase the risk of the other?

Output: pres-ence of one

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can increase the risk of the other?. ### Response: pres-ence of one.


Instruction: What type of comorbidities do patients with HF often have?

Output: bidirectional

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of comorbidities do patients with HF often have?. ### Response: bidirectional.


Instruction: What is the name of a patient who has HF?

Output: older patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of a patient who has HF?. ### Response: older patients.


Instruction: What do older patients often have that affect their prognosis?

Output: burdens

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do older patients often have that affect their prognosis?. ### Response: burdens.


Instruction: The presence of multiple chronicconditions is associated with increased what?

Output: symptom burden

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The presence of multiple chronicconditions is associated with increased what?. ### Response: symptom burden.


Instruction: What plays a role in a large proportion of hospitalizations?

Output: The presence of multiple chronicconditions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What plays a role in a large proportion of hospitalizations?. ### Response: The presence of multiple chronicconditions.


Instruction: What can greatly affect the treatment of HF and theability to optimize therapies?

Output: con-ditions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can greatly affect the treatment of HF and theability to optimize therapies?. ### Response: con-ditions.


Instruction: To optimally manage thesepatients and improve clinical outcomes, what must clinicians consider alongside the use of evidence-based HFtherapies?

Output: diagno sis and treatment of relevantcomorbidities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: To optimally manage thesepatients and improve clinical outcomes, what must clinicians consider alongside the use of evidence-based HFtherapies?. ### Response: diagno sis and treatment of relevantcomorbidities.


Instruction: What does HFtherapies treat?

Output: relevantcomorbidities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does HFtherapies treat?. ### Response: relevantcomorbidities.


Instruction: What is anotheri m p o r t a n ta sp e c to?

Output: Appropriate referral to clinicians with experi-ence treating the various comorbidities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is anotheri m p o r t a n ta sp e c to?. ### Response: Appropriate referral to clinicians with experi-ence treating the various comorbidities.


Instruction: What is a common comorbidity that deserves care-ful attention?

Output: Diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a common comorbidity that deserves care-ful attention?. ### Response: Diabetes.


Instruction: What is diabetes strongly associated with?

Output: the risk of both incident HF and adverse clinicaloutcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is diabetes strongly associated with?. ### Response: the risk of both incident HF and adverse clinicaloutcomes.


Instruction: Along with hypertension, coronary arterydisease, and chronic kidney disease, what co-morbid condition is closely linked to?

Output: Diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Along with hypertension, coronary arterydisease, and chronic kidney disease, what co-morbid condition is closely linked to?. ### Response: Diabetes.


Instruction: Treatment of pa-tients with T2D with SGLT2 inhibitors improves glycemiccontrol but also reduces HF events?

Output: pa-tients with established CV disease or CV risk factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Treatment of pa-tients with T2D with SGLT2 inhibitors improves glycemiccontrol but also reduces HF events?. ### Response: pa-tients with established CV disease or CV risk factors.


Instruction: SGLT2inhibitors decrease the risk of renal disease progres-sion in a manner additive to what?

Output: renin-angiotensin-aldosterone system inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: SGLT2inhibitors decrease the risk of renal disease progres-sion in a manner additive to what?. ### Response: renin-angiotensin-aldosterone system inhibitors.


Instruction: What is the name of the gene used for versal 16S rRNA gene PCR and sequencing?

Output: Staphylococcus aureus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the gene used for versal 16S rRNA gene PCR and sequencing?. ### Response: Staphylococcus aureus.


Instruction: When was the journal Diagn Microbiol InfectDis published?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the journal Diagn Microbiol InfectDis published?. ### Response: 2007.


Instruction: What is one of the reasons for low-level colonization of hospitalized patients with methicillin-resistant coagulase-negative staphylococci?

Output: emergence of the organisms during surgical antimicrobialprophylaxis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the reasons for low-level colonization of hospitalized patients with methicillin-resistant coagulase-negative staphylococci?. ### Response: emergence of the organisms during surgical antimicrobialprophylaxis.


Instruction: What type of staphylococci are coagulase-negative?

Output: methicillin-resistant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of staphylococci are coagulase-negative?. ### Response: methicillin-resistant.


Instruction: What year did Antimicrob Agents Chemother publish a study on antimicrobial susceptibility?

Output: 1994

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Antimicrob Agents Chemother publish a study on antimicrobial susceptibility?. ### Response: 1994.


Instruction: How many people were treated at Grady Memorial Hospital for endocarditis?

Output: 481–489.51

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were treated at Grady Memorial Hospital for endocarditis?. ### Response: 481–489.51.


Instruction: What is a macroproblem that starts with microadherence?

Output: Device-associated infections

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a macroproblem that starts with microadherence?. ### Response: Device-associated infections.


Instruction: What are the laboratory, clinical, and epidemiological aspects of coagulase-negative staphylococci?

Output: Antimicrobial susceptibility

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the laboratory, clinical, and epidemiological aspects of coagulase-negative staphylococci?. ### Response: Antimicrobial susceptibility.


Instruction: What is the name of the organism that causes catheter-related bacteremia in rabbits?

Output: Staphylococcusaureus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organism that causes catheter-related bacteremia in rabbits?. ### Response: Staphylococcusaureus.


Instruction: In what year was Microbiol Rev published?

Output: 1988

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was Microbiol Rev published?. ### Response: 1988.


Instruction: What was the number of cases of Staphylococcus epi-dermidis in 1988?

Output: 281

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the number of cases of Staphylococcus epi-dermidis in 1988?. ### Response: 281.


Instruction: How does capsular polysaccharide/adhesin protect rabbits against catheter-related bacteremia?

Output: Antibody

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does capsular polysaccharide/adhesin protect rabbits against catheter-related bacteremia?. ### Response: Antibody.


Instruction: What type of staphylococci causes endocarditis in rabbits?

Output: coagulase-negative

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of staphylococci causes endocarditis in rabbits?. ### Response: coagulase-negative.


Instruction: How does immunization of rabbits protect against endocarditis?

Output: capsular polysaccharide/adhesin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does immunization of rabbits protect against endocarditis?. ### Response: capsular polysaccharide/adhesin.


Instruction: Who wrote the book The Staphylococci in Human Disease?

Output: Wilkinson BJ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote the book The Staphylococci in Human Disease?. ### Response: Wilkinson BJ.


Instruction: What is the name of the book that Wilkinson BJ wrote about Staphylococci in Human Disease?

Output: The Staphylococci in Human Disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the book that Wilkinson BJ wrote about Staphylococci in Human Disease?. ### Response: The Staphylococci in Human Disease.


Instruction: Where is Churchill Livingston?

Output: New York, NY

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Churchill Livingston?. ### Response: New York, NY.


Instruction: What are the two proteins that play a role in the pathophysiology of foreign body infections?

Output: plasma and extracellularmatrix

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the two proteins that play a role in the pathophysiology of foreign body infections?. ### Response: plasma and extracellularmatrix.


Instruction: What is the name of the bacterium used to define the role of specific plasma proteins in promoting bacterial adhesion to canine arteriovenous shunts?

Output: Staphylococcus aureus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the bacterium used to define the role of specific plasma proteins in promoting bacterial adhesion to canine arteriovenous shunts?. ### Response: Staphylococcus aureus.


Instruction: Infect Immun.1995;63:585–590.59.

Output: 1995;63:3239

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Infect Immun.1995;63:585–590.59.. ### Response: 1995;63:3239.


Instruction: Infect Immun. 1995;63:585–590.59. Heilmann C, Schweitzer O, Gerke C, Vanittanakom N, Mack D, Götz F. What is the molecular basis of intercellular adhesion in the biofilm-forming Staph-ylococcus epidermidis?

Output: Molecular basis of intercellular adhesion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Infect Immun. 1995;63:585–590.59. Heilmann C, Schweitzer O, Gerke C, Vanittanakom N, Mack D, Götz F. What is the molecular basis of intercellular adhesion in the biofilm-forming Staph-ylococcus epidermidis?. ### Response: Molecular basis of intercellular adhesion.


Instruction: What could be a possible factor in colonisation of Holter shunts?

Output: Excessive production of mucoid substance instaphylococcus SIIA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could be a possible factor in colonisation of Holter shunts?. ### Response: Excessive production of mucoid substance instaphylococcus SIIA.


Instruction: What is instaphylococcus SIIA?

Output: Excessive production of mucoid substance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is instaphylococcus SIIA?. ### Response: Excessive production of mucoid substance.


Instruction: When did Dev Med Child Neurol Suppl. issue 27:25–28.61?

Output: 1972

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Dev Med Child Neurol Suppl. issue 27:25–28.61?. ### Response: 1972.


Instruction: What is the age of a person who has ESRD 14end-stage renal disease?

Output: >80 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the age of a person who has ESRD 14end-stage renal disease?. ### Response: >80 years.


Instruction: What is a risk factor when CrCl is >95 mL/min?

Output: caution

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor when CrCl is >95 mL/min?. ### Response: caution.


Instruction: What are the abbreviations for 1 and 2legends forexpansion?

Output: 1184 Evidence-Based Medicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the abbreviations for 1 and 2legends forexpansion?. ### Response: 1184 Evidence-Based Medicine.


Instruction: What is Evidence-Based Medicine?

Output: 1184 Evidence-Based Medicine [154#5 CHEST NOVEMBER 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Evidence-Based Medicine?. ### Response: 1184 Evidence-Based Medicine [154#5 CHEST NOVEMBER 2018.


Instruction: What did the Multi-Ethnic Study of Atherosclerosis do?

Output: long-term risk classification in individuals with type 2 diabetes and metabolic syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Multi-Ethnic Study of Atherosclerosis do?. ### Response: long-term risk classification in individuals with type 2 diabetes and metabolic syndrome.


Instruction: What is the phenotype of severe hypercholesterolemia?

Output: clinical diagnosis, management, and emerging thera-pies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the phenotype of severe hypercholesterolemia?. ### Response: clinical diagnosis, management, and emerging thera-pies.


Instruction: When was the J Am Coll Cardiol 63:1935-47?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol 63:1935-47?. ### Response: 2014.


Instruction: What is the name of the meta-analysis of low-density lipoprotein cholesterol and apolipoprotein B as markers of cardiovascular risk?

Output: meta-analysis of individual data from 27 randomised trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis of low-density lipoprotein cholesterol and apolipoprotein B as markers of cardiovascular risk?. ### Response: meta-analysis of individual data from 27 randomised trials.


Instruction: What are the names of the non-high density lipopolypentase choles-terol?

Output: apolipoprotein B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the non-high density lipopolypentase choles-terol?. ### Response: apolipoprotein B.


Instruction: When did Circ Cardiovasc Qual Outcomes. 2011:4:337–45?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circ Cardiovasc Qual Outcomes. 2011:4:337–45?. ### Response: 2011.


Instruction: What is the multi-ethnic study of atherosclerosis called?

Output: MESA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the multi-ethnic study of atherosclerosis called?. ### Response: MESA.


Instruction: What is a 10 year association of coronary artery calcium with?

Output: atherosclerotic cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a 10 year association of coronary artery calcium with?. ### Response: atherosclerotic cardiovascular disease.


Instruction: Who are the CTT Collaborators?

Output: Mihaylova B, Emberson J, et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who are the CTT Collaborators?. ### Response: Mihaylova B, Emberson J, et al.


Instruction: What is statin therapy used for in people at low risk of vascular disease?

Output: lowering LDL cholesterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is statin therapy used for in people at low risk of vascular disease?. ### Response: lowering LDL cholesterol.


Instruction: How many randomised trials were there in 2012?

Output: 27

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many randomised trials were there in 2012?. ### Response: 27.


Instruction: What is the name of the study that examined the risk of non-fatal cardiovascular diseases in early-onset versus late-onset type 2 diabetes in China?

Output: a cross-sectional study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined the risk of non-fatal cardiovascular diseases in early-onset versus late-onset type 2 diabetes in China?. ### Response: a cross-sectional study.


Instruction: What is the difference between late-onset type 2 diabetes in China?

Output: Risk of non-fatal cardiovascular diseases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between late-onset type 2 diabetes in China?. ### Response: Risk of non-fatal cardiovascular diseases.


Instruction: What is albuminuria and renal function as predictors of in a general population of type 2 diabetic patients?

Output: cardiovascular events and mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is albuminuria and renal function as predictors of in a general population of type 2 diabetic patients?. ### Response: cardiovascular events and mortality.


Instruction: What type of diabetes was a nationwide observational study from the Swedish National Diabetes Register?

Output: type 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diabetes was a nationwide observational study from the Swedish National Diabetes Register?. ### Response: type 2.


Instruction: What year did Diab Vasc Dis Res. 2013:10:520-9?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Diab Vasc Dis Res. 2013:10:520-9?. ### Response: 2013.


Instruction: Who conducted a systematic review and meta-analysis of cohort studies?

Output: Guo VY, Cao B, Wu X, et al. Prospective association between dia-betic retinopathy and cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who conducted a systematic review and meta-analysis of cohort studies?. ### Response: Guo VY, Cao B, Wu X, et al. Prospective association between dia-betic retinopathy and cardiovascular disease.


Instruction: What type of studies have been conducted?

Output: randomised trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of studies have been conducted?. ### Response: randomised trials.


Instruction: What is the risk of cardiovascular events in type 2 diabetes mel-litus?

Output: Peripheral neu-ropathy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of cardiovascular events in type 2 diabetes mel-litus?. ### Response: Peripheral neu-ropathy.


Instruction: How is peripheral neu-ropathy associated with cardiovascular events?

Output: the risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is peripheral neu-ropathy associated with cardiovascular events?. ### Response: the risk.


Instruction: What is asymptomatic peripheral arterial disease in 68-year-old men with diabetes?

Output: Prevalence and prognostic significance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is asymptomatic peripheral arterial disease in 68-year-old men with diabetes?. ### Response: Prevalence and prognostic significance.


Instruction: What is the population study "Men born in 1914" from Malmö, Sweden?

Output: Results

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the population study "Men born in 1914" from Malmö, Sweden?. ### Response: Results.


Instruction: What is an independent predictor of coronary heart disease and stroke risks in patients with type 2 diabetes mellitus in China?

Output: Lower extremity peripheral arterial disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an independent predictor of coronary heart disease and stroke risks in patients with type 2 diabetes mellitus in China?. ### Response: Lower extremity peripheral arterial disease.


Instruction: Int J Endocrinol. 2017;2017:9620513. S4.3-42. Waheed S, Pollack S, Roth M, et al. Collective impact of conventional cardiovascular risk factors and what else?

Output: coronary calcium score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Int J Endocrinol. 2017;2017:9620513. S4.3-42. Waheed S, Pollack S, Roth M, et al. Collective impact of conventional cardiovascular risk factors and what else?. ### Response: coronary calcium score.


Instruction: What is the name of the study that examined the collective impact of conventional cardiovascular risk factors and coronary calcium score on clinical out-comes with or without statin therapy?

Output: The St Francis Heart Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined the collective impact of conventional cardiovascular risk factors and coronary calcium score on clinical out-comes with or without statin therapy?. ### Response: The St Francis Heart Study.


Instruction: How much information is available on the duration of and long-term disease burden of hypertension?

Output: very limited

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much information is available on the duration of and long-term disease burden of hypertension?. ### Response: very limited.


Instruction: What do the consistent asso-ciations observed between hypotension and both mortality and bleeding suggest?

Output: avoidance of hypotension should be an important treatment principle in ACS patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do the consistent asso-ciations observed between hypotension and both mortality and bleeding suggest?. ### Response: avoidance of hypotension should be an important treatment principle in ACS patients.


Instruction: What should be an important treatment principle in ACS patients?

Output: avoidance of hypotension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be an important treatment principle in ACS patients?. ### Response: avoidance of hypotension.


Instruction: What is the cornerstone of the management of hypertension in patients with ACS?

Output: modification of the balance between myocar -dial oxygen supply and demand

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cornerstone of the management of hypertension in patients with ACS?. ### Response: modification of the balance between myocar -dial oxygen supply and demand.


Instruction: What is a clinical manifestation of an alteration in the supply-demand equation such that ischemia occurs at rest or at relatively low levels of demand?

Output: the development of an ACS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a clinical manifestation of an alteration in the supply-demand equation such that ischemia occurs at rest or at relatively low levels of demand?. ### Response: the development of an ACS.


Instruction: What increases myocardial oxygen?

Output: elevated BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What increases myocardial oxygen?. ### Response: elevated BP.


Instruction: What increases myocardial oxygen demand?

Output: elevated BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What increases myocardial oxygen demand?. ### Response: elevated BP.


Instruction: What can rapid and excessive lowering of the DBP result in?

Output: impairment of coronary blood flow and oxygen supply

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can rapid and excessive lowering of the DBP result in?. ### Response: impairment of coronary blood flow and oxygen supply.


Instruction: Patients with ACS often have what?

Output: vasomotor instability

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with ACS often have what?. ### Response: vasomotor instability.


Instruction: Patients with ACS often have vasomotor instability with an increased ten-dency to exaggerated responses to what?

Output: antihypertensive therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with ACS often have vasomotor instability with an increased ten-dency to exaggerated responses to what?. ### Response: antihypertensive therapy.


Instruction: Because specific trials of BP lowering have not been per-formed in patients with what condition?

Output: ACS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Because specific trials of BP lowering have not been per-formed in patients with what condition?. ### Response: ACS.


Instruction: What should the selection of antihypertensive agents for use in the patient who has ACS be focused on selecting?

Output: drugs that have an established evidence-base for risk reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should the selection of antihypertensive agents for use in the patient who has ACS be focused on selecting?. ### Response: drugs that have an established evidence-base for risk reduction.


Instruction: Who should be focused on selecting drugs that have an established evidence-base for risk reduction for patients with ACS independently of BP lower-ing?

Output: antihypertensive agents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should be focused on selecting drugs that have an established evidence-base for risk reduction for patients with ACS independently of BP lower-ing?. ### Response: antihypertensive agents.


Instruction: What should be titrated to full doses before taking these drugs?

Output: β-blockers, ACE inhibitors (or ARBs), and, in selected patients, aldosterone antagonists, should typically be titrated to full doses before other agents that do not have an established evidence base are initiated

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be titrated to full doses before taking these drugs?. ### Response: β-blockers, ACE inhibitors (or ARBs), and, in selected patients, aldosterone antagonists, should typically be titrated to full doses before other agents that do not have an established evidence base are initiated.


Instruction: What should aldosterone antagonists be titrated to before other agents are initiated?

Output: full doses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should aldosterone antagonists be titrated to before other agents are initiated?. ### Response: full doses.


Instruction: What has not been established specifi-cally for patients with ACS?

Output: Therapeutic targets for BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has not been established specifi-cally for patients with ACS?. ### Response: Therapeutic targets for BP.


Instruction: Current guidelines recommend a BP target of what?

Output: <140/90 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Current guidelines recommend a BP target of what?. ### Response: <140/90 mm Hg.


Instruction: How many mm Hg is recommended for patients with diabetes mellitus or CKD?

Output: <130/80

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mm Hg is recommended for patients with diabetes mellitus or CKD?. ### Response: <130/80.


Instruction: What is more important than management of hypertension in the acute phase of MI?

Output: second-ary prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more important than management of hypertension in the acute phase of MI?. ### Response: second-ary prevention.


Instruction: The BP may fluctuate early after what?

Output: ACS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The BP may fluctuate early after what?. ### Response: ACS.


Instruction: What should efforts focus on before BP is specifically targeted?

Output: pain control and clinical stabilization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should efforts focus on before BP is specifically targeted?. ### Response: pain control and clinical stabilization.


Instruction: How should the BP be lowered slowly?

Output: Second, the BP should be lowered slowly, and caution is advised to avoid decreases in DBP to <60 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How should the BP be lowered slowly?. ### Response: Second, the BP should be lowered slowly, and caution is advised to avoid decreases in DBP to <60 mm Hg.


Instruction: What should be avoided decreases in DBP to 60mm Hg?

Output: reduce coronary perfusion and worsen ischemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be avoided decreases in DBP to 60mm Hg?. ### Response: reduce coronary perfusion and worsen ischemia.


Instruction: What can worsen myocardial ischemia?

Output: decreases in DBP to <60 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can worsen myocardial ischemia?. ### Response: decreases in DBP to <60 mm Hg.


Instruction: A BP target of 130/80 mm Hg at the time of hospital discharge is what?

Output: reasonable option

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A BP target of 130/80 mm Hg at the time of hospital discharge is what?. ### Response: reasonable option.


Instruction: What may lead to very low DBP values in older hypertensive individu-als with wide pulse pressures?

Output: lowering SBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may lead to very low DBP values in older hypertensive individu-als with wide pulse pressures?. ### Response: lowering SBP.


Instruction: What has been a cornerstone of therapy for decades?

Output: Nitroglycerin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been a cornerstone of therapy for decades?. ### Response: Nitroglycerin.


Instruction: What is nitroglycerin effective in relieving in the hypertensive patient with ACS?

Output: symptoms of ischemia and pulmonary congestion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is nitroglycerin effective in relieving in the hypertensive patient with ACS?. ### Response: symptoms of ischemia and pulmonary congestion.


Instruction: What is the magnitude of bleeding risk when CABG is performed 1 to 4 days after the discontinuation of clopidogrelis less certain?

Output: little or no increased riskof major bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the magnitude of bleeding risk when CABG is performed 1 to 4 days after the discontinuation of clopidogrelis less certain?. ### Response: little or no increased riskof major bleeding.


Instruction: The incidence of life-threatening bleeding does not appear to be significantly increased during what time period?

Output: hours afterclopidogrel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The incidence of life-threatening bleeding does not appear to be significantly increased during what time period?. ### Response: hours afterclopidogrel.


Instruction: How long after discontinuing clopidogrel is it reasonable to delay elective CABG?

Output: /H113505days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after discontinuing clopidogrel is it reasonable to delay elective CABG?. ### Response: /H113505days.


Instruction: For patients requiring more urgent CABG, what can be performed /H1102224 hours?

Output: CABG for /H113505days after discontinuing clopidogrel. For patients requiringmore urgent CABG, it can be performed /H1102224 hours afterclopidogrel has been stopped

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For patients requiring more urgent CABG, what can be performed /H1102224 hours?. ### Response: CABG for /H113505days after discontinuing clopidogrel. For patients requiringmore urgent CABG, it can be performed /H1102224 hours afterclopidogrel has been stopped.


Instruction: How many patients undergo CABG after they have stopped taking the drug?

Output: 632

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients undergo CABG after they have stopped taking the drug?. ### Response: 632.


Instruction: What is the risk of major bleeding?

Output: higher in prasugrel-treated patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of major bleeding?. ### Response: higher in prasugrel-treated patients.


Instruction: How many days after clopidogreldiscontinuation do patients undergo CABG?

Output: 7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many days after clopidogreldiscontinuation do patients undergo CABG?. ### Response: 7.


Instruction: What are the concerns for patientstability, resource utilization, patient preference, and the confidence of the surgical team in managing hemostasis?

Output: Approximately two thirds of clopidogrel-treated patients undergo CABG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the concerns for patientstability, resource utilization, patient preference, and the confidence of the surgical team in managing hemostasis?. ### Response: Approximately two thirds of clopidogrel-treated patients undergo CABG.


Instruction: How has little experience with CABG in patients treated with prasu-grel been reported?

Output: Little

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How has little experience with CABG in patients treated with prasu-grel been reported?. ### Response: Little.


Instruction: What was the incidence of CABG-related majorbleeding higher in prasugrel-treated patients than in clopidogrel treated patients?

Output: 13.4% versus 3.2%;

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the incidence of CABG-related majorbleeding higher in prasugrel-treated patients than in clopidogrel treated patients?. ### Response: 13.4% versus 3.2%;.


Instruction: What should be delayed for /H113507 days after praspigrel?

Output: CABG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be delayed for /H113507 days after praspigrel?. ### Response: CABG.


Instruction: What should be delayed for /H113507 days after prasugrel is discontinued?

Output: CABG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be delayed for /H113507 days after prasugrel is discontinued?. ### Response: CABG.


Instruction: What is an oral agent that binds reversibly to the plateletP2Y12receptor?

Output: Ticagrelor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an oral agent that binds reversibly to the plateletP2Y12receptor?. ### Response: Ticagrelor.


Instruction: Which oral agent provides faster, more effective and more rapidrecovery of platelet function after discontinuation?

Output: Ticagrelor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which oral agent provides faster, more effective and more rapidrecovery of platelet function after discontinuation?. ### Response: Ticagrelor.


Instruction: How many patients underwent CABG within 7 days of the lastdose of the study drug?

Output: 632

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients underwent CABG within 7 days of the lastdose of the study drug?. ### Response: 632.


Instruction: How long after stopping clopidogrel did the study protocol recommend waiting?

Output: H113505 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after stopping clopidogrel did the study protocol recommend waiting?. ### Response: H113505 days.


Instruction: How long after ticagrelor did many patients undergo surgery before the recommended waiting times?

Output: 24 to 72hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after ticagrelor did many patients undergo surgery before the recommended waiting times?. ### Response: 24 to 72hours.


Instruction: What were the rates of major bleeding?

Output: 13.4% versus 3.2%;

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the rates of major bleeding?. ### Response: 13.4% versus 3.2%;.


Instruction: How many patients underwent surgery beforethe recommended waiting time?

Output: many

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients underwent surgery beforethe recommended waiting time?. ### Response: many.


Instruction: What did ticagrelor and clopidogrel have in common with respect to time from lastdose of study drug?

Output: no difference in bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did ticagrelor and clopidogrel have in common with respect to time from lastdose of study drug?. ### Response: no difference in bleeding.


Instruction: What was performed 1, 2, or 3days after discontinuation of study drugs?

Output: CABG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was performed 1, 2, or 3days after discontinuation of study drugs?. ### Response: CABG.


Instruction: Does the faster recovery of platelet function seen in pharmacokinetic studies translate to a lower risk?

Output: it does notappear that the more rapid recovery of platelet function seen inticagrelor pharmacokinetic studies translates to a lower risk ofbleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Does the faster recovery of platelet function seen in pharmacokinetic studies translate to a lower risk?. ### Response: it does notappear that the more rapid recovery of platelet function seen inticagrelor pharmacokinetic studies translates to a lower risk ofbleeding.


Instruction: Inticagrelor pharmacokinetic studies translates to a lower risk ofbleeding or less need for what?

Output: transfusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Inticagrelor pharmacokinetic studies translates to a lower risk ofbleeding or less need for what?. ### Response: transfusion.


Instruction: When is CABG performed early (ie, /H110215 days after drugdiscontinuation?

Output: 1, 2, or 3days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is CABG performed early (ie, /H110215 days after drugdiscontinuation?. ### Response: 1, 2, or 3days.


Instruction: What was the cause of one patient's ischemic foot?

Output: intraaortic balloon pump

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the cause of one patient's ischemic foot?. ### Response: intraaortic balloon pump.


Instruction: How many patients died during the postoperative period?

Output: Three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients died during the postoperative period?. ### Response: Three.


Instruction: What is the range of 3 months to 1 year?

Output: postoperative period

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the range of 3 months to 1 year?. ### Response: postoperative period.


Instruction: What is loprost?

Output: prostacyclin analogue

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is loprost?. ### Response: prostacyclin analogue.


Instruction: What was used to inhibit platelet activation dur-ing cardiac surgery?

Output: Iloprost

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was used to inhibit platelet activation dur-ing cardiac surgery?. ### Response: Iloprost.


Instruction: How many consecutive cardiac surgery patients were analysed?

Output: 1,518

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many consecutive cardiac surgery patients were analysed?. ### Response: 1,518.


Instruction: How many consecutive cardiac surgery patients did Palatianos analyze?

Output: 1,518

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many consecutive cardiac surgery patients did Palatianos analyze?. ### Response: 1,518.


Instruction: How many patients with clinicalsymptoms of HIT were identified with PF4-heparin antibodies?

Output: 10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with clinicalsymptoms of HIT were identified with PF4-heparin antibodies?. ### Response: 10.


Instruction: What did patients presenting with HIT receive?

Output: a protocol ofiloprost infusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did patients presenting with HIT receive?. ### Response: a protocol ofiloprost infusion.


Instruction: What drug was used in conjunction with heparin?

Output: tiro ﬁban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug was used in conjunction with heparin?. ### Response: tiro ﬁban.


Instruction: What was the postoperative reduction in platelet count in the iloprost group compared to the control group?

Output: 12.5% /C68.7%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the postoperative reduction in platelet count in the iloprost group compared to the control group?. ### Response: 12.5% /C68.7%).


Instruction: No thrombotic complications were detected in which group of patients?

Output: iloprost group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No thrombotic complications were detected in which group of patients?. ### Response: iloprost group.


Instruction: What was used in conjunction with a tiro fiban infusion during CPB?

Output: heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was used in conjunction with a tiro fiban infusion during CPB?. ### Response: heparin.


Instruction: There was no clinical or laboratory evidence of what?

Output: thrombosis or excessive bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There was no clinical or laboratory evidence of what?. ### Response: thrombosis or excessive bleeding.


Instruction: What has been reported with patientsrequiring renal replacement therapy?

Output: The use of argatroban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been reported with patientsrequiring renal replacement therapy?. ### Response: The use of argatroban.


Instruction: What should be limited to theseexceptional circumstances?

Output: argatroban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be limited to theseexceptional circumstances?. ### Response: argatroban.


Instruction: What is the norm?

Output: excessive bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the norm?. ### Response: excessive bleeding.


Instruction: Patients who are seropositive for heparin antibodies are at increased risk of both thrombosis and bleeding?

Output: asso-ciated with heparin alternatives

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients who are seropositive for heparin antibodies are at increased risk of both thrombosis and bleeding?. ### Response: asso-ciated with heparin alternatives.


Instruction: What is a thrombotic complication associated with rapid-onset HIT in patients with a recent history of HIT?

Output: catastrophic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a thrombotic complication associated with rapid-onset HIT in patients with a recent history of HIT?. ### Response: catastrophic.


Instruction: Avery high level of vigilance is recommended in patients exposed to what?

Output: heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Avery high level of vigilance is recommended in patients exposed to what?. ### Response: heparin.


Instruction: Patients warrant carefulsurveillance,thromboprophylaxis, and what else to manage the increased risk?

Output: treatments

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients warrant carefulsurveillance,thromboprophylaxis, and what else to manage the increased risk?. ### Response: treatments.


Instruction: What is the most commonly used anticoagu-lant during the CardiacOperationsClass IIa Recommendation/C15Protamine dosing for heparin reversal?

Output: Heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most commonly used anticoagu-lant during the CardiacOperationsClass IIa Recommendation/C15Protamine dosing for heparin reversal?. ### Response: Heparin.


Instruction: What has been associated with reducedbleeding and blood transfusion?

Output: Protamine dosing for heparin reversal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been associated with reducedbleeding and blood transfusion?. ### Response: Protamine dosing for heparin reversal.


Instruction: What is the most commonly used anticoagu-lant during the conduct of cardiac operations?

Output: Heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most commonly used anticoagu-lant during the conduct of cardiac operations?. ### Response: Heparin.


Instruction: What are the goals of successful anticoagulation during CPB?

Output: limiting clotting and safely reversing theanticoagulation effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the goals of successful anticoagulation during CPB?. ### Response: limiting clotting and safely reversing theanticoagulation effect.


Instruction: On what date did the AHA publish the AIS Guidelines online?

Output: April 18, 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On what date did the AHA publish the AIS Guidelines online?. ### Response: April 18, 2018.


Instruction: How many specific recommendations were deleted?

Output: 7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many specific recommendations were deleted?. ### Response: 7.


Instruction: What was removed from the revised AIS guidelines on April 18, 2018?

Output: 7 specific recommendations and all of Section 6, In-Hospital Institution of Secondary Prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was removed from the revised AIS guidelines on April 18, 2018?. ### Response: 7 specific recommendations and all of Section 6, In-Hospital Institution of Secondary Prevention.


Instruction: Who published the revised AHA Guidelines on December 11, 2017?

Output: the AHA Executive Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the revised AHA Guidelines on December 11, 2017?. ### Response: the AHA Executive Committee.


Instruction: What section of the guideline was the writing group asked to review?

Output: Section 6, In-Hospital Institution of Secondary Prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What section of the guideline was the writing group asked to review?. ### Response: Section 6, In-Hospital Institution of Secondary Prevention.


Instruction: What was included in the revised guideline?

Output: deleted recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was included in the revised guideline?. ### Response: deleted recommendations.


Instruction: When was the revised document submitted?

Output: April 18, 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the revised document submitted?. ### Response: April 18, 2018.


Instruction: How many participants were in the randomized controlled trials?

Output: >100

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many participants were in the randomized controlled trials?. ### Response: >100.


Instruction: How many participants were in a published randomized controlled trial?

Output: >100

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many participants were in a published randomized controlled trial?. ### Response: >100.


Instruction: How many peer reviewers reviewed the document?

Output: 14

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many peer reviewers reviewed the document?. ### Response: 14.


Instruction: Who reviewed the revision of the RCT?

Output: Stroke Council’s Scientific Statements Oversight Committee and the AHA Science Advisory and Coordinating Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who reviewed the revision of the RCT?. ### Response: Stroke Council’s Scientific Statements Oversight Committee and the AHA Science Advisory and Coordinating Committee.


Instruction: Who reviewed the Stroke Council's Scientific Statements Oversight Committee?

Output: AHA Science Advisory and Coordinating Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who reviewed the Stroke Council's Scientific Statements Oversight Committee?. ### Response: AHA Science Advisory and Coordinating Committee.


Instruction: Who reviewed RCTs address-ing AIS published between November 2018 and April 2019?

Output: the writing group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who reviewed RCTs address-ing AIS published between November 2018 and April 2019?. ### Response: the writing group.


Instruction: What was modified in Section 3.5.6., Recommendation 1?

Output: The document was sent out to 14 peer reviewers. The writing group evaluated the peer reviewers’ comments and revised when appropriate. This revised document was reviewed by Stroke Council’s Scientific Statements Oversight Committee and the AHA Science Advisory and Coordinating Committee. To allow these guidelines to be as timely as possible, RCTs address-ing AIS published between November 2018 and April 2019 were reviewed by the writing group. Modifications of Section 3.5.6., Recommendation 1, Section 3.6., Recommendation 4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was modified in Section 3.5.6., Recommendation 1?. ### Response: The document was sent out to 14 peer reviewers. The writing group evaluated the peer reviewers’ comments and revised when appropriate. This revised document was reviewed by Stroke Council’s Scientific Statements Oversight Committee and the AHA Science Advisory and Coordinating Committee. To allow these guidelines to be as timely as possible, RCTs address-ing AIS published between November 2018 and April 2019 were reviewed by the writing group. Modifications of Section 3.5.6., Recommendation 1, Section 3.6., Recommendation 4.


Instruction: How many revisions were made to Section 3.5.6., Recommendation 1, Section 3.6., and Recommandation 4?

Output: 14

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many revisions were made to Section 3.5.6., Recommendation 1, Section 3.6., and Recommandation 4?. ### Response: 14.


Instruction: When was the revised version of the revisions made?

Output: April 18, 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the revised version of the revisions made?. ### Response: April 18, 2018.


Instruction: What is the name of the group that made the changes?

Output: the AHA Executive Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that made the changes?. ### Response: the AHA Executive Committee.


Instruction: What is required of any writing committee member who develops new RWI during his or her tenure on the writing committee?

Output: to notify staff in writing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is required of any writing committee member who develops new RWI during his or her tenure on the writing committee?. ### Response: to notify staff in writing.


Instruction: Who reviews the statements in writing?

Output: the Task Force and by members of the writingcommittee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who reviews the statements in writing?. ### Response: the Task Force and by members of the writingcommittee.


Instruction: What are the authors and peer reviewer RWI relevant to?

Output: thedocument

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the authors and peer reviewer RWI relevant to?. ### Response: thedocument.


Instruction: What are the appendices for?

Output: Author and peer reviewer RWI relevant to thedocument

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the appendices for?. ### Response: Author and peer reviewer RWI relevant to thedocument.


Instruction: What is included in Appendix A for relevant writing committee RWI?

Output: Author and peer reviewer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is included in Appendix A for relevant writing committee RWI?. ### Response: Author and peer reviewer.


Instruction: How is the disclosure information for the writing committee available?

Output: on-line

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the disclosure information for the writing committee available?. ### Response: on-line.


Instruction: What is available on-line at http://jaccjacc.cardiosource.com/DataSupp/ACCF/2013_Comprehensive_RWI_WC.pdf?

Output: writing committeemembers ’comprehensive disclosure information

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is available on-line at http://jaccjacc.cardiosource.com/DataSupp/ACCF/2013_Comprehensive_RWI_WC.pdf?. ### Response: writing committeemembers ’comprehensive disclosure information.


Instruction: Who supported the work of the writing committee?

Output: ACC, the AHA, and the AMA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who supported the work of the writing committee?. ### Response: ACC, the AHA, and the AMA.


Instruction: What did the writing committee volunteer their time for?

Output: this effort

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the writing committee volunteer their time for?. ### Response: this effort.


Instruction: Who attended the meetings of thewriting committee?

Output: committee members and staff from the ACC, AHA,SCAI, AMA-PCPI, and NCQA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who attended the meetings of thewriting committee?. ### Response: committee members and staff from the ACC, AHA,SCAI, AMA-PCPI, and NCQA.


Instruction: What is the development of performance measurement systems?

Output: involves identi ﬁcation of a set of measures targeting aspeciﬁc patient population observed over a particular timeperiod

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the development of performance measurement systems?. ### Response: involves identi ﬁcation of a set of measures targeting aspeciﬁc patient population observed over a particular timeperiod.


Instruction: What is the goal of the ACC/AHA Task Force on Performance Measures?

Output: The development of performance measurement systemsinvolves identi ﬁcation of a set of measures targeting aspeciﬁc patient population observed over a particular timeperiod

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the goal of the ACC/AHA Task Force on Performance Measures?. ### Response: The development of performance measurement systemsinvolves identi ﬁcation of a set of measures targeting aspeciﬁc patient population observed over a particular timeperiod.


Instruction: What is a set of mandatorysequential steps?

Output: the ACC/AHA Task Forceon Performance Measures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a set of mandatorysequential steps?. ### Response: the ACC/AHA Task Forceon Performance Measures.


Instruction: What did the writing committee seek to identify to guide the selection of measures for inclusion in themeasure set?

Output: structures, processes, and outcomes that are most mean-ingful to patients undergoing PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the writing committee seek to identify to guide the selection of measures for inclusion in themeasure set?. ### Response: structures, processes, and outcomes that are most mean-ingful to patients undergoing PCI.


Instruction: What was a key aspect of determining outcomes that are most relevant to patientsundergoing PCI?

Output: performance measurement systems

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a key aspect of determining outcomes that are most relevant to patientsundergoing PCI?. ### Response: performance measurement systems.


Instruction: What was a key aspect of determining outcomes that are most relevant for patients?

Output: performance measurement systems

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a key aspect of determining outcomes that are most relevant for patients?. ### Response: performance measurement systems.


Instruction: What is a complete list of the desirable outcomesidenti fid by the writing committee?

Output: measurespeciﬁcations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a complete list of the desirable outcomesidenti fid by the writing committee?. ### Response: measurespeciﬁcations.


Instruction: Where can you find the qmeasure?

Output: check/qmeasure.cgi

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find the qmeasure?. ### Response: check/qmeasure.cgi.


Instruction: What did the writing committee identify as relevant dimensions of care?

Output: each potential performancemeasure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the writing committee identify as relevant dimensions of care?. ### Response: each potential performancemeasure.


Instruction: What did classi fication into dimensions of care facilitate?

Output: identi ﬁcation of areas in which evidence was lackingand prevented duplication of measures within the set

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did classi fication into dimensions of care facilitate?. ### Response: identi ﬁcation of areas in which evidence was lackingand prevented duplication of measures within the set.


Instruction: What prevented duplication of measures within the set?

Output: Classi ﬁcation into dimensions of care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What prevented duplication of measures within the set?. ### Response: Classi ﬁcation into dimensions of care.


Instruction: What was the HR of the composite of primary CVdisease outcome or all-cause death?

Output: 0.66

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the HR of the composite of primary CVdisease outcome or all-cause death?. ### Response: 0.66.


Instruction: What was there no description of potential harm of achieving lower targets in this subgroup of older adults withCKD?

Output: 91

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was there no description of potential harm of achieving lower targets in this subgroup of older adults withCKD?. ### Response: 91.


Instruction: What was the benefit ratio in the whole CKDcohort and in the entire subcohort older than 75 years inSPRINT?

Output: 0.64

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the benefit ratio in the whole CKDcohort and in the entire subcohort older than 75 years inSPRINT?. ### Response: 0.64.