Instruction: What is TRITON-TIMI 38?

Output: Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition with Prasugrel—Thrombolysis In Myocardial Infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is TRITON-TIMI 38?. ### Response: Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition with Prasugrel—Thrombolysis In Myocardial Infarction.


Instruction: What is Prasugrel used for?

Output: Thrombolysis In Myocardial Infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Prasugrel used for?. ### Response: Thrombolysis In Myocardial Infarction.


Instruction: How many studies were conducted on patients with reduced-function CYP2C19*2 alleles?

Output: 286–288

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were conducted on patients with reduced-function CYP2C19*2 alleles?. ### Response: 286–288.


Instruction: What was the effect of clopi-dogrel on platelet inhibition?

Output: diminished

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the effect of clopi-dogrel on platelet inhibition?. ### Response: diminished.


Instruction: What has the US Food and Drug Administration changed to highlight the potential impact of CYP2C19 genotype on clopidogrel's pharmacokinetics and clinical response?

Output: clopido-grel’s prescribing information

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has the US Food and Drug Administration changed to highlight the potential impact of CYP2C19 genotype on clopidogrel's pharmacokinetics and clinical response?. ### Response: clopido-grel’s prescribing information.


Instruction: Other studies have not con-firmed associations between what polymorphisms and adverse outcomes?

Output: CYP2C19

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Other studies have not con-firmed associations between what polymorphisms and adverse outcomes?. ### Response: CYP2C19.


Instruction: CYP2C19 polymorphisms and adverse outcomes in clopidogrel-treated patients are what?

Output: other studies have not con-firmed associations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: CYP2C19 polymorphisms and adverse outcomes in clopidogrel-treated patients are what?. ### Response: other studies have not con-firmed associations.


Instruction: Future studies are needed to further clarify the risk associated with what genetic phenotype?

Output: CYP2C19

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Future studies are needed to further clarify the risk associated with what genetic phenotype?. ### Response: CYP2C19.


Instruction: Proton-pump inhibitors, most prominently omeprazole, can interfere with what drug?

Output: clopidogrel metabolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Proton-pump inhibitors, most prominently omeprazole, can interfere with what drug?. ### Response: clopidogrel metabolism.


Instruction: Proton-pump inhibitors interfere with what?

Output: clopidogrel metabolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Proton-pump inhibitors interfere with what?. ### Response: clopidogrel metabolism.


Instruction: What does omeprazole do to clopidogrel?

Output: interfere with clopidogrel metabolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does omeprazole do to clopidogrel?. ### Response: interfere with clopidogrel metabolism.


Instruction: What did Smith AJ, Turner EL, Kinra S. Do universal cholesterol screening in childhood have a systematic review?

Output: Universal cholesterol screening in childhood: a systematic review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Smith AJ, Turner EL, Kinra S. Do universal cholesterol screening in childhood have a systematic review?. ### Response: Universal cholesterol screening in childhood: a systematic review.


Instruction: What did Kerr M, Pears R, Miedzybrodzka Z, et al. Cost effectiveness of cascade testing for?

Output: familial hypercholesterolaemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Kerr M, Pears R, Miedzybrodzka Z, et al. Cost effectiveness of cascade testing for?. ### Response: familial hypercholesterolaemia.


Instruction: What is hypercholesterolaemia services in the UK called?

Output: familial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hypercholesterolaemia services in the UK called?. ### Response: familial.


Instruction: What is the name of the journal that was downloaded from http://ahajournals.org by on May 1, 2023?

Output: Eur Heart J

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that was downloaded from http://ahajournals.org by on May 1, 2023?. ### Response: Eur Heart J.


Instruction: What is the name of the study that found survival aftercoronary revascularization among patients with kidney disease?

Output: Circu-lation.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that found survival aftercoronary revascularization among patients with kidney disease?. ### Response: Circu-lation..


Instruction: When was the Circu-lation. 110:1890–5.480 published?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circu-lation. 110:1890–5.480 published?. ### Response: 2004.


Instruction: What is a common cause of kidney disease in patients with significant coronary artery disease in 2003?

Output: mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a common cause of kidney disease in patients with significant coronary artery disease in 2003?. ### Response: mortality.


Instruction: What is the difference between percutaneous coronary interventionversus coronary artery bypass grafting in patients with coronaryarterydisease and diabetic nephropathy: a single center experience?

Output: clinicaloutcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between percutaneous coronary interventionversus coronary artery bypass grafting in patients with coronaryarterydisease and diabetic nephropathy: a single center experience?. ### Response: clinicaloutcomes.


Instruction: What is the name of the study that studies the association of chronic kidneydisease with clinical outcomes after coronary revascularization?

Output: Arterial Revascularization Therapies Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that studies the association of chronic kidneydisease with clinical outcomes after coronary revascularization?. ### Response: Arterial Revascularization Therapies Study.


Instruction: What does ARTS stand for?

Output: Arterial Revascularization Therapies Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ARTS stand for?. ### Response: Arterial Revascularization Therapies Study.


Instruction: What is the acronym for the Arterial Revascularization Therapies Study?

Output: ARTS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the Arterial Revascularization Therapies Study?. ### Response: ARTS.


Instruction: When was the ARTS published?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the ARTS published?. ### Response: 2005.


Instruction: What was the name of the study that evaluated outcomes after coronary revascularization?

Output: Arterial Revascularization Therapies Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the study that evaluated outcomes after coronary revascularization?. ### Response: Arterial Revascularization Therapies Study.


Instruction: What is the difference in survival aftercoronary revascularization procedures among patients with renal insuf-ficiency?

Output: Differential survival aftercoronary revascularization procedures among patients with renal insuf-ficiency. Kidney Int. 2001;60:292–9.486

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference in survival aftercoronary revascularization procedures among patients with renal insuf-ficiency?. ### Response: Differential survival aftercoronary revascularization procedures among patients with renal insuf-ficiency. Kidney Int. 2001;60:292–9.486.


Instruction: What year did Kidney Int. 60:292–9.486?

Output: 2001

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Kidney Int. 60:292–9.486?. ### Response: 2001.


Instruction: Jones EL, Craver JM, Guyton RA, et al. Importance of what in performance of the coronary bypass operation?

Output: completerevascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Jones EL, Craver JM, Guyton RA, et al. Importance of what in performance of the coronary bypass operation?. ### Response: completerevascularization.


Instruction: What year did Cardiol. 51:7–12.487 occur?

Output: 1983

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Cardiol. 51:7–12.487 occur?. ### Response: 1983.


Instruction: What is important for cardiac event-free survival?

Output: complete revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is important for cardiac event-free survival?. ### Response: complete revascularization.


Instruction: When was Percutaneous transluminalangioplasty performed in multivessel coronary disease?

Output: 1990

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Percutaneous transluminalangioplasty performed in multivessel coronary disease?. ### Response: 1990.


Instruction: What did the NHLBI PTCA Registry report?

Output: Long-term outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the NHLBI PTCA Registry report?. ### Response: Long-term outcome.


Instruction: What did Faxon DP, Ghalilli K, Jacobs AK, et al. Do patients have complete or incomplete revascularization after multi-vessel coronary angioplasty?

Output: incomplete vs complete

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Faxon DP, Ghalilli K, Jacobs AK, et al. Do patients have complete or incomplete revascularization after multi-vessel coronary angioplasty?. ### Response: incomplete vs complete.


Instruction: What type of surgery improvessurvival compared with medical therapy?

Output: coronary artery bypass

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of surgery improvessurvival compared with medical therapy?. ### Response: coronary artery bypass.


Instruction: What is BARI?

Output: BypassAngioplasty Revascularization Investigation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is BARI?. ### Response: BypassAngioplasty Revascularization Investigation.


Instruction: When was BARI conducted?

Output: 2001

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was BARI conducted?. ### Response: 2001.


Instruction: What is the difference between stentimplantation and by-pass grafting in severe leftventricular dysfunction?

Output: outcome comparison

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between stentimplantation and by-pass grafting in severe leftventricular dysfunction?. ### Response: outcome comparison.


Instruction: Catheter Car-diovasc Interv. 2007;70:26–33.e712 Circulation December 6, 2011

Output: Gioia G, Matthai W, Gillin K, et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Catheter Car-diovasc Interv. 2007;70:26–33.e712 Circulation December 6, 2011. ### Response: Gioia G, Matthai W, Gillin K, et al.


Instruction: What is the focus of CLINICAL St AteMeNtS ANd GuIdeLINeSHeart Failure Focused Update on Pharmacological TherapyCirculation. 2016;134:e282-e293. DOI: 10.1161/CIR.0000000000000435 September 27, 2016 e291Appendix 2.

Output: Reviewer Relationships With Industry and other entities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the focus of CLINICAL St AteMeNtS ANd GuIdeLINeSHeart Failure Focused Update on Pharmacological TherapyCirculation. 2016;134:e282-e293. DOI: 10.1161/CIR.0000000000000435 September 27, 2016 e291Appendix 2.. ### Response: Reviewer Relationships With Industry and other entities.


Instruction: Who is the official reviewer for the ACC/AHA Task Force on Clinical Practice Guidelines?

Output: Kim K. Birtcher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the official reviewer for the ACC/AHA Task Force on Clinical Practice Guidelines?. ### Response: Kim K. Birtcher.


Instruction: What is the name of the Director of Heart Failure Disease Management?

Output: Akshay S. Desai

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Director of Heart Failure Disease Management?. ### Response: Akshay S. Desai.


Instruction: Who is the Director of Heart Failure Disease Management at HFSABrigham and Women’s Hospital?

Output: Akshay S. Desai

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Director of Heart Failure Disease Management at HFSABrigham and Women’s Hospital?. ### Response: Akshay S. Desai.


Instruction: What is the name of the Associate Professor of Medicine at Harvard Medical School?

Output: Akshay S. Desai

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Associate Professor of Medicine at Harvard Medical School?. ### Response: Akshay S. Desai.


Instruction: What is the name of the official reviewer for Novartis?

Output: Anita Deswal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the official reviewer for Novartis?. ### Response: Anita Deswal.


Instruction: Who is the Director of Heart Failure Program at AHAMichael E. DeBakey VA Medical Center?

Output: Anita Deswal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Director of Heart Failure Program at AHAMichael E. DeBakey VA Medical Center?. ### Response: Anita Deswal.


Instruction: Which college is the Professor of Medicine at Baylor College of Medicine?

Output: University of Houston College of Pharmacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which college is the Professor of Medicine at Baylor College of Medicine?. ### Response: University of Houston College of Pharmacy.


Instruction: Where is Robert and Georgia Roth Endowed Chair?

Output: Newport Coast Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Robert and Georgia Roth Endowed Chair?. ### Response: Newport Coast Cardiology.


Instruction: Who is the Endowed Chair for Excellence in Cardiac Care at Newport Coast Cardiology?

Output: Robert and Georgia Roth

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Endowed Chair for Excellence in Cardiac Care at Newport Coast Cardiology?. ### Response: Robert and Georgia Roth.


Instruction: What is the name of the official reviewer at AHAMontefiore Medical Center?

Output: Ileana L. Piña

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the official reviewer at AHAMontefiore Medical Center?. ### Response: Ileana L. Piña.


Instruction: Who is a Director of Disease Management at St. Jude Medical?

Output: Dipti Itchhaporia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a Director of Disease Management at St. Jude Medical?. ### Response: Dipti Itchhaporia.


Instruction: Who is the official reviewer for the ACC Board of Governors?

Output: Geetha Raghuveer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the official reviewer for the ACC Board of Governors?. ### Response: Geetha Raghuveer.


Instruction: What is the name of the professor of pediatrics at Children’s Mercy Hospital?

Output: Geetha Raghuveer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor of pediatrics at Children’s Mercy Hospital?. ### Response: Geetha Raghuveer.


Instruction: Who is a professor and associate dean of International and Community Programs at Azusa Pacific University?

Output: Cheryl Westlake

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a professor and associate dean of International and Community Programs at Azusa Pacific University?. ### Response: Cheryl Westlake.


Instruction: What table represents the relationships of committee members with industry and other entities that were determined to be relevant to this document?

Output: Appendix 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What table represents the relationships of committee members with industry and other entities that were determined to be relevant to this document?. ### Response: Appendix 2.


Instruction: What is a significant interest in a business if the interest represents ownership of 5% of the voting stock or share of the business?

Output: A person is deemed to have a significant interest in a business if the interest represents ownership of ≥5% of the voting stock or share of the business entity, or ownership of ≥$5000 of the fair market value of the business entity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a significant interest in a business if the interest represents ownership of 5% of the voting stock or share of the business?. ### Response: A person is deemed to have a significant interest in a business if the interest represents ownership of ≥5% of the voting stock or share of the business entity, or ownership of ≥$5000 of the fair market value of the business entity.


Instruction: The table does not necessarily reflect what at the time of publication?

Output: relationships with industry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The table does not necessarily reflect what at the time of publication?. ### Response: relationships with industry.


Instruction: What percentage of the voting stock or share of the business entity is owned by the person?

Output: ≥5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the voting stock or share of the business entity is owned by the person?. ### Response: ≥5%.


Instruction: How much of the fair market value of a business entity does the person own?

Output: ≥$5000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the fair market value of a business entity does the person own?. ### Response: ≥$5000.


Instruction: What is the amount of money received by a person from a company that exceeds 5% of the value of the company?

Output: ≥$5000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the amount of money received by a person from a company that exceeds 5% of the value of the company?. ### Response: ≥$5000.


Instruction: What is the acronym for American College of Cardiology?

Output: ACC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for American College of Cardiology?. ### Response: ACC.


Instruction: What is DSMB?

Output: data safety monitoring board

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is DSMB?. ### Response: data safety monitoring board.


Instruction: How does HRS stand for Heart Rhythm Society?

Output: Heart Rhythm Society

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does HRS stand for Heart Rhythm Society?. ### Response: Heart Rhythm Society.


Instruction: What is an example of inappropriate sinus tachycardia?

Output: multifocal atrial tachycardia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of inappropriate sinus tachycardia?. ### Response: multifocal atrial tachycardia.


Instruction: What is the name of the randomized controlled trial?

Output: RCT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized controlled trial?. ### Response: RCT.


Instruction: Where can you download the appendix 3 from?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you download the appendix 3 from?. ### Response: http://ahajournals.org.


Instruction: What is the name of the 2018 Cholesterol Clinical Practice Guidelines?

Output: Grundy et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2018 Cholesterol Clinical Practice Guidelines?. ### Response: Grundy et al.


Instruction: What does the higher the 10-year ASCVD risk, the greater is the ben-efit from increased LDL-C reduction?

Output: S4.3-12

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the higher the 10-year ASCVD risk, the greater is the ben-efit from increased LDL-C reduction?. ### Response: S4.3-12.


Instruction: What is supported by the meta-analyses comparing high-intensity versus -low intensity statin therapy?

Output: S4.3-12 the higher the 10-year ASCVD risk, the greater is the ben-efit from increased LDL-C reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is supported by the meta-analyses comparing high-intensity versus -low intensity statin therapy?. ### Response: S4.3-12 the higher the 10-year ASCVD risk, the greater is the ben-efit from increased LDL-C reduction.


Instruction: What do statins and nonstatin therapeutic agents upregu-late?

Output: LDL receptors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do statins and nonstatin therapeutic agents upregu-late?. ### Response: LDL receptors.


Instruction: How much LDL-C lowering does ezetimibe 10 mg/d achieve?

Output: ≥50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much LDL-C lowering does ezetimibe 10 mg/d achieve?. ### Response: ≥50%.


Instruction: What percentage of patients had diabetes mellitus in this RCT?

Output: 27%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients had diabetes mellitus in this RCT?. ### Response: 27%.


Instruction: What can be considered if a high-intensity statin cannot be tolerated or does not lower LDL-C by 50%?

Output: ezetimibe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be considered if a high-intensity statin cannot be tolerated or does not lower LDL-C by 50%?. ### Response: ezetimibe.


Instruction: What is high in adults >75 years of age with diabetes mellitus who are not receiving statin therapy?

Output: the risk of ASCVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is high in adults >75 years of age with diabetes mellitus who are not receiving statin therapy?. ### Response: the risk of ASCVD.


Instruction: What may be limited by their reduced life span or increased susceptibility to adverse effects of statin?

Output: the benefit of initiating statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be limited by their reduced life span or increased susceptibility to adverse effects of statin?. ### Response: the benefit of initiating statin therapy.


Instruction: What is the term for a reduced life span or increased susceptibility to adverse effects of treatment?

Output: statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for a reduced life span or increased susceptibility to adverse effects of treatment?. ### Response: statin therapy.


Instruction: What is not well known about the impact of diabetes mellitus on ASCVD risk?

Output: indi-viduals with recent or newly diagnosed diabetes mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not well known about the impact of diabetes mellitus on ASCVD risk?. ### Response: indi-viduals with recent or newly diagnosed diabetes mellitus.


Instruction: What is limited information on among individuals 20 to 39 years of age with diabetes mellitus?

Output: ASCVD rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is limited information on among individuals 20 to 39 years of age with diabetes mellitus?. ### Response: ASCVD rates.


Instruction: What is no information on whether statin therapy is effective in this age group?

Output: ASCVD rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is no information on whether statin therapy is effective in this age group?. ### Response: ASCVD rates.


Instruction: What type of therapy is not beneficial in diabetes mellitus patients?

Output: statin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is not beneficial in diabetes mellitus patients?. ### Response: statin.


Instruction: What are the rates of ASCVD in those 30 years of age?

Output: low

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the rates of ASCVD in those 30 years of age?. ### Response: low.


Instruction: How old are people with type 2 diabetes mellitus at risk for ASCVD?

Output: ≥20%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old are people with type 2 diabetes mellitus at risk for ASCVD?. ### Response: ≥20%.


Instruction: What type of diabetes is more likely to have advanced subclinical coronary athero-sclerosis than non-diabetic subjects?

Output: type 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diabetes is more likely to have advanced subclinical coronary athero-sclerosis than non-diabetic subjects?. ### Response: type 2.


Instruction: How long is the duration of type 1 diabetes meillitus?

Output: >20 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the duration of type 1 diabetes meillitus?. ### Response: >20 years.


Instruction: How long have patients had type 2 diabetes mellitus for?

Output: at least 10 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long have patients had type 2 diabetes mellitus for?. ### Response: at least 10 years.


Instruction: What are the ASCVD rates influ-enced by?

Output: hypertension and diabetic microvascu-lar complications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the ASCVD rates influ-enced by?. ### Response: hypertension and diabetic microvascu-lar complications.


Instruction: How long has type 2 diabetes mellitus been active?

Output: at least 10 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long has type 2 diabetes mellitus been active?. ### Response: at least 10 years.


Instruction: How long does type 1 diabetes meillitus last?

Output: >20 years’ duration.S4.3-23 ASCVD rates will also be influ-enced by hypertension and diabetic microvascu-lar complications that may be prevalent in these age groups.S4.3-18,S4.3-23 Thus, it may be reasonable to have a discussion about initiating moderate-intensity statin therapy with patients who have had type 2 diabetes mellitus for at least 10 years or type 1 diabetes mellitus for at least 20 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does type 1 diabetes meillitus last?. ### Response: >20 years’ duration.S4.3-23 ASCVD rates will also be influ-enced by hypertension and diabetic microvascu-lar complications that may be prevalent in these age groups.S4.3-18,S4.3-23 Thus, it may be reasonable to have a discussion about initiating moderate-intensity statin therapy with patients who have had type 2 diabetes mellitus for at least 10 years or type 1 diabetes mellitus for at least 20 years.


Instruction: What type of diabetes is most common in patients with 1 or more major CVD?

Output: type 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diabetes is most common in patients with 1 or more major CVD?. ### Response: type 2.


Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020 Page 116 of 127 ii?

Output: If the answer is “No” to Box 4, then Box 6, in the shape of a hexagon, asks the question: “Does patient have CVD per Sidebar 1 , DM, or LDL ≥ 190 mg/dL?”  1) If the answer is “Yes” to Box 6, then Box 7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020 Page 116 of 127 ii?. ### Response: If the answer is “No” to Box 4, then Box 6, in the shape of a hexagon, asks the question: “Does patient have CVD per Sidebar 1 , DM, or LDL ≥ 190 mg/dL?”  1) If the answer is “Yes” to Box 6, then Box 7.


Instruction: What shape is Box 6 in?

Output: hexagon

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What shape is Box 6 in?. ### Response: hexagon.


Instruction: What type of statin is recommended for patients with CVD?

Output: moderate -dose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of statin is recommended for patients with CVD?. ### Response: moderate -dose.


Instruction: What is the shape of Box 7?

Output: rectangle

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the shape of Box 7?. ### Response: rectangle.


Instruction: What shape is Box 8 in?

Output: hexagon

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What shape is Box 8 in?. ### Response: hexagon.


Instruction: What is the shape of Box 9?

Output: hexagon

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the shape of Box 9?. ### Response: hexagon.


Instruction: Is patient’s 10 -year risk 6 -12% or does patient prefer statin treatment?

Output: 12%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Is patient’s 10 -year risk 6 -12% or does patient prefer statin treatment?. ### Response: 12%.


Instruction: If the answer is “Yes” to Box 9, then what shape is Box 7?

Output: rectangle

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: If the answer is “Yes” to Box 9, then what shape is Box 7?. ### Response: rectangle.


Instruction: What is the shape of Box 12?

Output: rectangle

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the shape of Box 12?. ### Response: rectangle.


Instruction: What type of exercise would you recommend?

Output: regular aerobic exercise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of exercise would you recommend?. ### Response: regular aerobic exercise.


Instruction: What is associated with benefit when compared to mostly sedentary behavior?

Output: walking, landscaping, washing dishes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with benefit when compared to mostly sedentary behavior?. ### Response: walking, landscaping, washing dishes.


Instruction: A provider's considerations when recommending physical activity might include a patient's motivation, functional capacity, and what else?

Output: physical activity preferences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A provider's considerations when recommending physical activity might include a patient's motivation, functional capacity, and what else?. ### Response: physical activity preferences.


Instruction: What does Box 12 connect to Box 13?

Output: rectangle: “Follow up evaluation: 1. Primary prevention, no statin:  Lipids every  10 years, recommend non- fasting ; Repeat risk evaluation at Box 1: Every 2 years if 6 – 12%, Every  5 years if <6%, If risk factors change. 2. Secondary prevention: lipids as needed only if higher risk and willing to intensify; 3. Once on optimal therapy, no need to recheck lipids routinely”  3. Box 7 connects to Box 11, in the shape of a rectangle: “ Recommend dietitian -led Mediterranean diet for risk >12% ” 4. Box 11

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Box 12 connect to Box 13?. ### Response: rectangle: “Follow up evaluation: 1. Primary prevention, no statin:  Lipids every  10 years, recommend non- fasting ; Repeat risk evaluation at Box 1: Every 2 years if 6 – 12%, Every  5 years if <6%, If risk factors change. 2. Secondary prevention: lipids as needed only if higher risk and willing to intensify; 3. Once on optimal therapy, no need to recheck lipids routinely”  3. Box 7 connects to Box 11, in the shape of a rectangle: “ Recommend dietitian -led Mediterranean diet for risk >12% ” 4. Box 11.


Instruction: How often does Box 1 repeat risk evaluation?

Output: Every 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often does Box 1 repeat risk evaluation?. ### Response: Every 2.


Instruction: How often do you repeat risk evaluation at Box 1?

Output: Every 2 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often do you repeat risk evaluation at Box 1?. ### Response: Every 2 years.


Instruction: How many years if risk factors change?

Output: 5 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many years if risk factors change?. ### Response: 5 years.


Instruction: What is secondary prevention?

Output: lipids as needed only if higher risk and willing to intensify

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is secondary prevention?. ### Response: lipids as needed only if higher risk and willing to intensify.


Instruction: When on optimal therapy, no need to recheck lipids routinely?

Output: Once

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When on optimal therapy, no need to recheck lipids routinely?. ### Response: Once.


Instruction: What shape does Box 7 connect to Box 11?

Output: rectangle

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What shape does Box 7 connect to Box 11?. ### Response: rectangle.


Instruction: What type of diet is recommended for risk >12%?

Output: Mediterranean diet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diet is recommended for risk >12%?. ### Response: Mediterranean diet.


Instruction: Box 11 connects to Box 12 in what shape?

Output: rectangle

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Box 11 connects to Box 12 in what shape?. ### Response: rectangle.


Instruction: What is the shape of a rectangle?

Output: Box 7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the shape of a rectangle?. ### Response: Box 7.


Instruction: What is associated with incremental benefit with increased doses of physical activity?

Output: lower doses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with incremental benefit with increased doses of physical activity?. ### Response: lower doses.


Instruction: How much lower was the rate of all-cause death at 2 years with TAVI than with standard medical therapy?

Output: 43.3%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much lower was the rate of all-cause death at 2 years with TAVI than with standard medical therapy?. ### Response: 43.3%).


Instruction: What percentage of patients received standard therapy with percutaneous aortic balloon dilation in 84% of patients?

Output: 58%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients received standard therapy with percutaneous aortic balloon dilation in 84% of patients?. ### Response: 58%.


Instruction: How much less of a reduction in repeat hospital-ization did TAVI cause?

Output: 55% versus 72.5%;

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much less of a reduction in repeat hospital-ization did TAVI cause?. ### Response: 55% versus 72.5%;.


Instruction: What percentage of survivors were in New York Heart Association class III or IV 1 year after TAVI?

Output: 25.2%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of survivors were in New York Heart Association class III or IV 1 year after TAVI?. ### Response: 25.2%.


Instruction: How many patients received standard therapy?

Output: 58%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients received standard therapy?. ### Response: 58%.


Instruction: What was the rate of major stroke?

Output: 5.05% versus 1.0%;

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the rate of major stroke?. ### Response: 5.05% versus 1.0%;.


Instruction: How much higher was the rate of major stroke with TAVI than with standard therapy at 30 days?

Output: 5.05% versus 1.0%;

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much higher was the rate of major stroke with TAVI than with standard therapy at 30 days?. ### Response: 5.05% versus 1.0%;.


Instruction: What percentage of patients with major vascular complications had TAVI compared to standard therapy?

Output: 16.2%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients with major vascular complications had TAVI compared to standard therapy?. ### Response: 16.2%.


Instruction: How much of a difference was there between TAVI and standard therapy after 2 years?

Output: <25%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of a difference was there between TAVI and standard therapy after 2 years?. ### Response: <25%.


Instruction: What was the rate of all-cause death at 12 months with TAVI?

Output: 26%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the rate of all-cause death at 12 months with TAVI?. ### Response: 26%.


Instruction: What is the expected mortality rate of 43% if treated with standard therapy?

Output: 68%).

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the expected mortality rate of 43% if treated with standard therapy?. ### Response: 68%)..


Instruction: How many patients with severe symptomatic AS and extreme surgical risk were studied?

Output: 489

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with severe symptomatic AS and extreme surgical risk were studied?. ### Response: 489.


Instruction: What is the expected mortality rate if patients had been treated medically?

Output: 43%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the expected mortality rate if patients had been treated medically?. ### Response: 43%.


Instruction: What is based on a shared decision-making process that accounts for the patient’s values and preferences?

Output: The final choice of TAVI versus palliative care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is based on a shared decision-making process that accounts for the patient’s values and preferences?. ### Response: The final choice of TAVI versus palliative care.


Instruction: What is the benefit of TAVI seen only in appropriately selected patients?

Output: survival and symptom reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the benefit of TAVI seen only in appropriately selected patients?. ### Response: survival and symptom reduction.


Instruction: What are the baseline clinical factors associated with a poor outcome after TAVI?

Output: advanced age, frailty, smoking or chronic obstructive pulmonary disease, pulmonary hypertension, liver disease, prior stroke, anemia, and other systemic condi-tions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the baseline clinical factors associated with a poor outcome after TAVI?. ### Response: advanced age, frailty, smoking or chronic obstructive pulmonary disease, pulmonary hypertension, liver disease, prior stroke, anemia, and other systemic condi-tions.


Instruction: What is the STS estimated surgical risk score?

Output: patient comorbidities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the STS estimated surgical risk score?. ### Response: patient comorbidities.


Instruction: What is a useful measure of the extent of patient comorbidities?

Output: STS estimated surgical risk score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a useful measure of the extent of patient comorbidities?. ### Response: STS estimated surgical risk score.


Instruction: What is a mechanical impediment to SAVR?

Output: por -celain aorta or prior chest radiation damage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a mechanical impediment to SAVR?. ### Response: por -celain aorta or prior chest radiation damage.


Instruction: Patients with a por -celain aorta or prior chest radiation damage may have better outcomes after what?

Output: TAVI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with a por -celain aorta or prior chest radiation damage may have better outcomes after what?. ### Response: TAVI.


Instruction: What are the likely benefits and risks of TAVI considered in weighing the risk-benefit ratio of intervention in an individual patient?

Output: indication, risks, and benefits

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the likely benefits and risks of TAVI considered in weighing the risk-benefit ratio of intervention in an individual patient?. ### Response: indication, risks, and benefits.


Instruction: What is not recommended in patients with 1) a life expectancy of 1 year even with a successful procedure or 2) who have a  1 year even if a procedure is successful?

Output: TAVI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended in patients with 1) a life expectancy of 1 year even with a successful procedure or 2) who have a  1 year even if a procedure is successful?. ### Response: TAVI.


Instruction: What percentage of patients have a chance of survival with benefit at 2 years?

Output: <25%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients have a chance of survival with benefit at 2 years?. ### Response: <25%.


Instruction: When was this article downloaded?

Output: April 27, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this article downloaded?. ### Response: April 27, 2023.


Instruction: What is the salary of an expert witness?

Output: BureauOwnership/Partnership/PrincipalPersonal ResearchInstitutional, Organizational, or Other Financial Benefit Expert Witness Salary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the salary of an expert witness?. ### Response: BureauOwnership/Partnership/PrincipalPersonal ResearchInstitutional, Organizational, or Other Financial Benefit Expert Witness Salary.


Instruction: When was this salary released?

Output: May 1, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this salary released?. ### Response: May 1, 2023.


Instruction: Where can you find this salary?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find this salary?. ### Response: http://ahajournals.org.


Instruction: What is most useful when there is a clinical suspicion of an alt ernativ e diagnosis?

Output: committ ee agr eed t hat CT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is most useful when there is a clinical suspicion of an alt ernativ e diagnosis?. ### Response: committ ee agr eed t hat CT.


Instruction: What should not be r outinely per formed f or everyone wit h a suspect ed TIA?

Output: CT brain imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not be r outinely per formed f or everyone wit h a suspect ed TIA?. ### Response: CT brain imaging.


Instruction: What confirms a diagnosis in a suspect TIA patient?

Output: MRI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What confirms a diagnosis in a suspect TIA patient?. ### Response: MRI.


Instruction: Routine CT imaging is common in what type of practice?

Output: curr ent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Routine CT imaging is common in what type of practice?. ### Response: curr ent.


Instruction: What did the committee discuss t he possible risks of not off ering CT brain imaging to everyone with suspect ed TIA?

Output: if t here was an incr ease in MRI r equest s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee discuss t he possible risks of not off ering CT brain imaging to everyone with suspect ed TIA?. ### Response: if t here was an incr ease in MRI r equest s.


Instruction: What is a suspect ed TIA?

Output: CT brain imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a suspect ed TIA?. ### Response: CT brain imaging.


Instruction: What is rar e for a CT scan?

Output: reveal an alt ernativ e diagnosis needing a diff erent r eferral pat hway

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is rar e for a CT scan?. ### Response: reveal an alt ernativ e diagnosis needing a diff erent r eferral pat hway.


Instruction: What is rar e for a CT scan to reveal an alt ernativ e diagnosis needing a diff erent r eferral pat hway?

Output: it rar ely confirms a diagnosis in t hese patient s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is rar e for a CT scan to reveal an alt ernativ e diagnosis needing a diff erent r eferral pat hway?. ### Response: it rar ely confirms a diagnosis in t hese patient s.


Instruction: What should not incr ease gr eatly?

Output: the number of r eferrals t o TIA clinics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not incr ease gr eatly?. ### Response: the number of r eferrals t o TIA clinics.


Instruction: In a TIA clinic, not all people will need what?

Output: an MRI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In a TIA clinic, not all people will need what?. ### Response: an MRI.


Instruction: What is the vascular territory of ischaemia?

Output: t he region of t he brain wit h loss of blood flo w

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the vascular territory of ischaemia?. ### Response: t he region of t he brain wit h loss of blood flo w.


Instruction: What is supplied by either t he ant erior or post eior cir culation?

Output: region of t he brain wit h loss of blood flo w

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is supplied by either t he ant erior or post eior cir culation?. ### Response: region of t he brain wit h loss of blood flo w.


Instruction: What is a car otid endar terectomy?

Output: tumours, dem yelinating disor ders or con vexity subarachnoid haemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a car otid endar terectomy?. ### Response: tumours, dem yelinating disor ders or con vexity subarachnoid haemorrhage.


Instruction: What is an alt ernativ e pat hologies such as tumours, demyelinating disor ders or convexity subarachnoid haemorrhage?

Output: car otid endar terectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an alt ernativ e pat hologies such as tumours, demyelinating disor ders or convexity subarachnoid haemorrhage?. ### Response: car otid endar terectomy.


Instruction: What is MRI screening impr oves the out comes f or people wit h suspected TIA?

Output: r outine MRI scr eening

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is MRI screening impr oves the out comes f or people wit h suspected TIA?. ### Response: r outine MRI scr eening.


Instruction: What did the committee make a research recommendation on?

Output: early MRI brain scanning

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee make a research recommendation on?. ### Response: early MRI brain scanning.


Instruction: What will CT brain imaging be a change in?

Output: practice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will CT brain imaging be a change in?. ### Response: practice.


Instruction: What aligns with MRI use in t he TIA clinic?

Output: curr ent practice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What aligns with MRI use in t he TIA clinic?. ### Response: curr ent practice.


Instruction: What aligns br oadly with current practice?

Output: Routine CT imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What aligns br oadly with current practice?. ### Response: Routine CT imaging.


Instruction: What was uncer tain whet her t hese r ecommendations will be cost sa ving o verall?

Output: The committ ee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was uncer tain whet her t hese r ecommendations will be cost sa ving o verall?. ### Response: The committ ee.


Instruction: What is a potential incr ease in MRI request?

Output: a challenge

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a potential incr ease in MRI request?. ### Response: a challenge.


Instruction: What does the committee highlight that an y eduction in CT r equest s ma y be?

Output: possible risks of not off ering CT brain imaging t o everyone with a suspect ed TIA. The y agr eed t hat, in t he absence of clinical 'r ed flag' indicat ors (f or example, headache, anticoagulation, head injur y, repetitiv e stereotyped e vents), it is rar e for a CT scan t o reveal an alt ernativ e diagnosis needing a diff erent r eferral pat hway

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the committee highlight that an y eduction in CT r equest s ma y be?. ### Response: possible risks of not off ering CT brain imaging t o everyone with a suspect ed TIA. The y agr eed t hat, in t he absence of clinical 'r ed flag' indicat ors (f or example, headache, anticoagulation, head injur y, repetitiv e stereotyped e vents), it is rar e for a CT scan t o reveal an alt ernativ e diagnosis needing a diff erent r eferral pat hway.


Instruction: What will not generally be aff ected by the result s of a previous CT scan?

Output: MRI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will not generally be aff ected by the result s of a previous CT scan?. ### Response: MRI.


Instruction: The committee recognised that if t here was an incr ease in MRI r equests, what could be a challenge?

Output: access t o high-quality MRI scanners is limit ed in some trust s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committee recognised that if t here was an incr ease in MRI r equests, what could be a challenge?. ### Response: access t o high-quality MRI scanners is limit ed in some trust s.


Instruction: Access to high-quality MRI scanners is limit ed in some trusts?

Output: TIA clinics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Access to high-quality MRI scanners is limit ed in some trusts?. ### Response: TIA clinics.


Instruction: Stroke and transient ischaemic attack in o ver 16s: diagnosis and initial management(NG128) NICE 2023. All right s reserved

Output: In Stroke and transient ischaemic attack in o ver 16s: diagnosis and initial management(NG128)© NICE 2023 . All right s reserved.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Stroke and transient ischaemic attack in o ver 16s: diagnosis and initial management(NG128) NICE 2023. All right s reserved. ### Response: In Stroke and transient ischaemic attack in o ver 16s: diagnosis and initial management(NG128)© NICE 2023 . All right s reserved..


Instruction: What is the subject t o Notice of right s?

Output: https://www .nice.or g.uk/t erms-and-conditions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the subject t o Notice of right s?. ### Response: https://www .nice.or g.uk/t erms-and-conditions.


Instruction: Last updat ed 13 April 2022Page 32of 48

Output: t he decision t o per form an MRI will not generally be aff ected by the result s of a previous CT scan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Last updat ed 13 April 2022Page 32of 48. ### Response: t he decision t o per form an MRI will not generally be aff ected by the result s of a previous CT scan.


Instruction: What is the title of the 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive SummaryCirculation. 2019;140:e563–e595. DOI: 10.1161/CIR.0000000000000677 September 10, 2019 e593CLINICAL STATEMENTS AND GUIDELINESPamela Morris Content Reviewer—ACCProfessor, Medical University of South Carolina

Output: Arnett et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of the 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive SummaryCirculation. 2019;140:e563–e595. DOI: 10.1161/CIR.0000000000000677 September 10, 2019 e593CLINICAL STATEMENTS AND GUIDELINESPamela Morris Content Reviewer—ACCProfessor, Medical University of South Carolina. ### Response: Arnett et al.


Instruction: Who is the ACC Director of Clinical Cardiology and Operations?

Output: Andrew Freeman

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the ACC Director of Clinical Cardiology and Operations?. ### Response: Andrew Freeman.


Instruction: What is the Co-Director of Nuclear Cardiology?

Output: Andrew FreemanContent Reviewer—ACCDirector, Clinical Cardiology and Operations; Co-Director, Nuclear Cardiology, National Jewish Health

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Co-Director of Nuclear Cardiology?. ### Response: Andrew FreemanContent Reviewer—ACCDirector, Clinical Cardiology and Operations; Co-Director, Nuclear Cardiology, National Jewish Health.


Instruction: Which company is the Content Reviewer?

Output: Amgen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which company is the Content Reviewer?. ### Response: Amgen.


Instruction: Who is the Content Reviewer for the UW Health Preventive Cardiology Program?

Output: James Stein

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Content Reviewer for the UW Health Preventive Cardiology Program?. ### Response: James Stein.


Instruction: What is the Robert Turell Professor in Cardiovascular Research at UW?

Output: UW School of Medicine and Public Health

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Robert Turell Professor in Cardiovascular Research at UW?. ### Response: UW School of Medicine and Public Health.


Instruction: What is the name of Eli Lilly and Company?

Output: DSMB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of Eli Lilly and Company?. ### Response: DSMB.


Instruction: Who is a Content Reviewer at the University of Wisconsin School of Medicine and Public Health?

Output: Heather Johnson

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a Content Reviewer at the University of Wisconsin School of Medicine and Public Health?. ### Response: Heather Johnson.


Instruction: Who is a content reviewer at Emory University School of Medicine?

Output: Nanette Wenger

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a content reviewer at Emory University School of Medicine?. ### Response: Nanette Wenger.


Instruction: What is the name of the department of cardiology that is ACCProfessor of Medicine at Emmory University?

Output: Division of Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the department of cardiology that is ACCProfessor of Medicine at Emmory University?. ### Response: Division of Cardiology.


Instruction: Who is the author of the content review for Janssen Pharmaceuticals, Inc.?

Output: Nanette Wenger

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of the content review for Janssen Pharmaceuticals, Inc.?. ### Response: Nanette Wenger.


Instruction: Who is the Content Reviewer at the Ciccarone Center for the Prevention of Heart Disease?

Output: Michael Blaha

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Content Reviewer at the Ciccarone Center for the Prevention of Heart Disease?. ### Response: Michael Blaha.


Instruction: Who is a professor of medicine at Johns Hopkins?

Output: Michael Blaha

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a professor of medicine at Johns Hopkins?. ### Response: Michael Blaha.


Instruction: What is the name of the company that is associated with Regeneron Pharmaceuticals?

Output: Sanofi

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the company that is associated with Regeneron Pharmaceuticals?. ### Response: Sanofi.


Instruction: Who is the founder and Director of Preventive Cardiology at the Emory Clinic?

Output: Laurence Sperling

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the founder and Director of Preventive Cardiology at the Emory Clinic?. ### Response: Laurence Sperling.


Instruction: What is the Co-Director of the Cardiovascular Disease Fellowship Program at Emmory?

Output: Laurence Sperling

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Co-Director of the Cardiovascular Disease Fellowship Program at Emmory?. ### Response: Laurence Sperling.


Instruction: Who is a Content Reviewer for the Advanced Lipid Disorders Program of the Ciccarone Center?

Output: Seth Martin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a Content Reviewer for the Advanced Lipid Disorders Program of the Ciccarone Center?. ### Response: Seth Martin.


Instruction: Who is an Associate Professor of Medicine at Johns Hopkins Medicine?

Output: Seth Martin Content Reviewer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is an Associate Professor of Medicine at Johns Hopkins Medicine?. ### Response: Seth Martin Content Reviewer.


Instruction: Who is the co-inventor of Corrie Health?

Output: Johns Hopkins University

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the co-inventor of Corrie Health?. ### Response: Johns Hopkins University.


Instruction: What is the name of the company that is associated with Johns Hopkins Medicine?

Output: Janssen Pharmaceuticals, Inc

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the company that is associated with Johns Hopkins Medicine?. ### Response: Janssen Pharmaceuticals, Inc.


Instruction: What type of role does a Fiduciary have?

Output: Officer, Director, Trustee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of role does a Fiduciary have?. ### Response: Officer, Director, Trustee.


Instruction: Who is the co-inventor of a pending patent filed by Johns Hopkins University for method of LDL-C estimation?

Output: Corrie Health

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the co-inventor of a pending patent filed by Johns Hopkins University for method of LDL-C estimation?. ### Response: Corrie Health.


Instruction: What is recommended after CABG to all patients with LV dysfunction (EF 40%) or previous MI (Class I; Level of Evidence B)?

Output: pre-operative fasting plasma glucose and HbA1c measurements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended after CABG to all patients with LV dysfunction (EF 40%) or previous MI (Class I; Level of Evidence B)?. ### Response: pre-operative fasting plasma glucose and HbA1c measurements.


Instruction: In the absence of contraindications, what is recommended?

Output: ACE inhibitor or ARB therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the absence of contraindications, what is recommended?. ### Response: ACE inhibitor or ARB therapy.


Instruction: What is an aldosterone antagonist on top of?

Output: β-blocker and ACE inhibitor therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an aldosterone antagonist on top of?. ### Response: β-blocker and ACE inhibitor therapy.


Instruction: What is a class NYHA class II to IV heart failure symptoms?

Output: Class IIa

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a class NYHA class II to IV heart failure symptoms?. ### Response: Class IIa.


Instruction: What is the class of heart failure symptoms?

Output: hypoglycemic episodes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the class of heart failure symptoms?. ### Response: hypoglycemic episodes.


Instruction: What percentage of patients with LV dysfunction have EF 35%?

Output: <35%),

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients with LV dysfunction have EF 35%?. ### Response: <35%),.


Instruction: How long is it recommended to use ICD for the prevention of sudden cardiac death after CABG?

Output: 3 months of postoperative goal-directed medical therapy has been provided and persistent LV dysfunction has been confirmed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is it recommended to use ICD for the prevention of sudden cardiac death after CABG?. ### Response: 3 months of postoperative goal-directed medical therapy has been provided and persistent LV dysfunction has been confirmed.


Instruction: What type of LV dysfunction has been confirmed?

Output: persistent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of LV dysfunction has been confirmed?. ### Response: persistent.


Instruction: What is diabetes mellitus associated with after cardiac surgery?

Output: increased mortality and morbidity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is diabetes mellitus associated with after cardiac surgery?. ### Response: increased mortality and morbidity.


Instruction: What is associated with increased mortality and morbidity after cardiac surgery in general and CABG specifically?

Output: diabetes mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with increased mortality and morbidity after cardiac surgery in general and CABG specifically?. ### Response: diabetes mellitus.


Instruction: Diabetes mellitus is classified as what if it results from -cell destruction?

Output: type 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Diabetes mellitus is classified as what if it results from -cell destruction?. ### Response: type 2.


Instruction: Genetic defects in insulin secretion and drug-induced diabetes mellitus are examples of what?

Output: diabetes mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Genetic defects in insulin secretion and drug-induced diabetes mellitus are examples of what?. ### Response: diabetes mellitus.


Instruction: What has traditionally been the diagnosis of diabetes?

Output: fasting plasma glucose >126 mg/dL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has traditionally been the diagnosis of diabetes?. ### Response: fasting plasma glucose >126 mg/dL.


Instruction: A fasting plasma glucose >126 mg/dL and a 2-hour plasma glu-cose >200 mg-dL after oral administration of insulin have been the two main causes of what type of disease?

Output: diabetes mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A fasting plasma glucose >126 mg/dL and a 2-hour plasma glu-cose >200 mg-dL after oral administration of insulin have been the two main causes of what type of disease?. ### Response: diabetes mellitus.


Instruction: Besides insulin resistance, what other causes of diabetes exist?

Output: hypoglycemic episodes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Besides insulin resistance, what other causes of diabetes exist?. ### Response: hypoglycemic episodes.


Instruction: What type of test was recommended in 2009?

Output: hemoglobin A1c

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of test was recommended in 2009?. ### Response: hemoglobin A1c.


Instruction: How long did it take for a patient with diabetes mellitus to have a plasma glucose of >200 mg/dL after oral administration of 75 g glucose?

Output: 2-hour

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for a patient with diabetes mellitus to have a plasma glucose of >200 mg/dL after oral administration of 75 g glucose?. ### Response: 2-hour.


Instruction: What is another name for the hemoglobin A1c test?

Output: HbA1c

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for the hemoglobin A1c test?. ### Response: HbA1c.


Instruction: When did an International Expert Committee recommend the use of HbA1c?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did an International Expert Committee recommend the use of HbA1c?. ### Response: 2009.


Instruction: What is used as a diagnostic criterion for diabetes mellitus?

Output: fasting plasma glucose >126 mg/dL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used as a diagnostic criterion for diabetes mellitus?. ### Response: fasting plasma glucose >126 mg/dL.


Instruction: What is the threshold for the hemoglobin A1c test?

Output: >6.5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the threshold for the hemoglobin A1c test?. ### Response: >6.5%.


Instruction: Why is it not always known if a patient has dia-betes or glucose intolerance before surgery?

Output: adverse effects of hypoglycemic episodes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is it not always known if a patient has dia-betes or glucose intolerance before surgery?. ### Response: adverse effects of hypoglycemic episodes.


Instruction: All patients undergoing CABG to have pre-operative fasting plasma glucose and HbA1c measurements?

Output: 271Because it is not always known whether a patient has dia-betes mellitus or glucose intolerance before surgery, it is reasonable for all patients undergoing CABG to have pre-operative fasting plasma glucose and HbA1c measurements. This may facilitate optimal diabetes mellitus management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: All patients undergoing CABG to have pre-operative fasting plasma glucose and HbA1c measurements?. ### Response: 271Because it is not always known whether a patient has dia-betes mellitus or glucose intolerance before surgery, it is reasonable for all patients undergoing CABG to have pre-operative fasting plasma glucose and HbA1c measurements. This may facilitate optimal diabetes mellitus management.


Instruction: What may facilitate optimal diabetes mellitus management in the perioperative and postoperative periods?

Output: pre-operative fasting plasma glucose and HbA1c measurements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may facilitate optimal diabetes mellitus management in the perioperative and postoperative periods?. ### Response: pre-operative fasting plasma glucose and HbA1c measurements.


Instruction: What has been shown to improve both short and long-term outcomes after CABG in most studies?

Output: glucose goal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been shown to improve both short and long-term outcomes after CABG in most studies?. ### Response: glucose goal.


Instruction: What may fail to improve clinical outcomes?

Output: an overly aggressive lowering of serum glucose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may fail to improve clinical outcomes?. ### Response: an overly aggressive lowering of serum glucose.


Instruction: What is the glycemic goal?

Output: moderate glycemic control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the glycemic goal?. ### Response: moderate glycemic control.


Instruction: How many CABG patients were included in a large study?

Output: >4500

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many CABG patients were included in a large study?. ### Response: >4500.


Instruction: What were the mortality and complication rates among diabetic patients?

Output: lowest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the mortality and complication rates among diabetic patients?. ### Response: lowest.


Instruction: What is the benefit of improved cardiovascular outcomes outweighing the potential harm of adverse events?

Output: The benefit of improved cardiovascular outcomes outweighs the potential harm of adverse events, and patients are generally accepting of HTN therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the benefit of improved cardiovascular outcomes outweighing the potential harm of adverse events?. ### Response: The benefit of improved cardiovascular outcomes outweighs the potential harm of adverse events, and patients are generally accepting of HTN therapy.


Instruction: Patients are generally accepting of what type of therapy?

Output: HTN

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients are generally accepting of what type of therapy?. ### Response: HTN.


Instruction: Some patients are concerned about the AEs of what?

Output: medication

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Some patients are concerned about the AEs of what?. ### Response: medication.


Instruction: Recommendation 8 for patients 60 years and over with type 2 diabetes?

Output: we recommend treating to a systolic blood pressure goal of <140 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Recommendation 8 for patients 60 years and over with type 2 diabetes?. ### Response: we recommend treating to a systolic blood pressure goal of <140 mm Hg.


Instruction: What is the systolic blood pressure goal?

Output: <140 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the systolic blood pressure goal?. ### Response: <140 mm Hg.


Instruction: mm Hg with added benefit to lowering systolic blood pressure further for those between what?

Output: 130 mm Hg and 140 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: mm Hg with added benefit to lowering systolic blood pressure further for those between what?. ### Response: 130 mm Hg and 140 mm Hg.


Instruction: Comorbidities and issues of patient preference that may influence the choice of tests or therapies are considered what?

Output: randomized trials are unavailable, there may be a very clear clinical consensus that a particular test or therapy isuseful or effective

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Comorbidities and issues of patient preference that may influence the choice of tests or therapies are considered what?. ### Response: randomized trials are unavailable, there may be a very clear clinical consensus that a particular test or therapy isuseful or effective.


Instruction: When available, information from studies on what is considered?

Output: cost

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When available, information from studies on what is considered?. ### Response: cost.


Instruction: Data on efficacy and outcomes constitute what basis for the recommendations contained herein?

Output: primary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Data on efficacy and outcomes constitute what basis for the recommendations contained herein?. ### Response: primary.


Instruction: What does the writing committee use in analyzing data and developing recommendations?

Output: evidence-basedmethodologies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the writing committee use in analyzing data and developing recommendations?. ### Response: evidence-basedmethodologies.


Instruction: What is the Class ofRecommendation?

Output: Class I and IIa

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Class ofRecommendation?. ### Response: Class I and IIa.


Instruction: What does COR stand for?

Output: Class ofRecommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does COR stand for?. ### Response: Class ofRecommendation.


Instruction: What is an estimate of the certainty or precision of the treatment effect?

Output: The Level of Evidence (LOE)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an estimate of the certainty or precision of the treatment effect?. ### Response: The Level of Evidence (LOE).


Instruction: What is the weight of evidence ranked as according to thewriting committee?

Output: LOE A, B, or C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the weight of evidence ranked as according to thewriting committee?. ### Response: LOE A, B, or C.


Instruction: What type of studies are identified as observational,retrospective, prospective, or randomized where appropriate?

Output: Studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of studies are identified as observational,retrospective, prospective, or randomized where appropriate?. ### Response: Studies.


Instruction: For conditions for which inadequate data are avail-able, recommendations are ranked as what?

Output: LOE C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For conditions for which inadequate data are avail-able, recommendations are ranked as what?. ### Response: LOE C.


Instruction: What are recommen-dations at LOE C supported by?

Output: historical clinical data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are recommen-dations at LOE C supported by?. ### Response: historical clinical data.


Instruction: What is the basis for a survey of current practice among the clinicians on the writing commit-tee?

Output: LOE C recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the basis for a survey of current practice among the clinicians on the writing commit-tee?. ### Response: LOE C recommendations.


Instruction: Who is the basis for LOE C recommendations?

Output: a surveyof current practice among the clinicians on the writing commit-tee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the basis for LOE C recommendations?. ### Response: a surveyof current practice among the clinicians on the writing commit-tee.


Instruction: What is the schema for COR and LOE summarized in?

Output: TableTable 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the schema for COR and LOE summarized in?. ### Response: TableTable 1.


Instruction: Applying Classification of Recommendations and Level of Evidence does not imply that the recommendation is what?

Output: weak

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Applying Classification of Recommendations and Level of Evidence does not imply that the recommendation is what?. ### Response: weak.


Instruction: Evidence B or C does not imply that the recommendation is weak.

Output: Applying Classification of Recommendations and Level of EvidenceA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Evidence B or C does not imply that the recommendation is weak.. ### Response: Applying Classification of Recommendations and Level of EvidenceA.


Instruction: What does not lend themselves to clinical trials?

Output: Many important clinical questions addressed in the guide lines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not lend themselves to clinical trials?. ### Response: Many important clinical questions addressed in the guide lines.


Instruction: What type of data is available from clinical trials or registries about the usefulness/efficacy in different subpopulations?

Output: sex, age, history of prior my ocardial infarction,history of heart failure, and prior aspirin use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of data is available from clinical trials or registries about the usefulness/efficacy in different subpopulations?. ### Response: sex, age, history of prior my ocardial infarction,history of heart failure, and prior aspirin use.


Instruction: What is available for comparative effectiveness recommendations?

Output: information from studies on cost

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is available for comparative effectiveness recommendations?. ### Response: information from studies on cost.


Instruction: What are recommendations that support the use of comparator verbs?

Output: Class I and IIa; Level of Evidence A and B only

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are recommendations that support the use of comparator verbs?. ### Response: Class I and IIa; Level of Evidence A and B only.


Instruction: What do recommendations involve?

Output: omparisons of the treatments or strategies being evaluated

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do recommendations involve?. ### Response: omparisons of the treatments or strategies being evaluated.


Instruction: When was the ACCF/AHA CABG Guideline e655 downloaded?

Output: April 26, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the ACCF/AHA CABG Guideline e655 downloaded?. ### Response: April 26, 2023.


Instruction: What is the effect of angiotensin re-ceptor blockade on systemic right ventricular function and size?

Output: a small, randomized, placebo-controlled study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of angiotensin re-ceptor blockade on systemic right ventricular function and size?. ### Response: a small, randomized, placebo-controlled study.


Instruction: What is a small, randomized, placebo-controlled study?

Output: S3.14.1-13. Therrien J, Provost Y, Harrison J, et al. Effect of angiotensin re-ceptor blockade

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a small, randomized, placebo-controlled study?. ### Response: S3.14.1-13. Therrien J, Provost Y, Harrison J, et al. Effect of angiotensin re-ceptor blockade.


Instruction: What does ACE inhibition do in symptomatic heart failure patients with a systemic right ventricle?

Output: Safety and efficiency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ACE inhibition do in symptomatic heart failure patients with a systemic right ventricle?. ### Response: Safety and efficiency.


Instruction: What is the name of the study that investigated the safety and efficacy of ACE inhibitors in patients with right ventricular systemic dysfunction?

Output: The EVEDES Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the safety and efficacy of ACE inhibitors in patients with right ventricular systemic dysfunction?. ### Response: The EVEDES Study.


Instruction: What is valsar -tan used for?

Output: systemic right ventricular function: a double-blind, ran-domized, placebo-controlled pilot trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is valsar -tan used for?. ### Response: systemic right ventricular function: a double-blind, ran-domized, placebo-controlled pilot trial.


Instruction: What is Eplerenone used for in the systemic right ventricle?

Output: double blind randomized clinical trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Eplerenone used for in the systemic right ventricle?. ### Response: double blind randomized clinical trial.


Instruction: What does Eplerenone do in systemic right ventricle?

Output: double blind randomized clinical trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Eplerenone do in systemic right ventricle?. ### Response: double blind randomized clinical trial.


Instruction: What is the name of the double blind randomized clinical trial?

Output: The EVEDES Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the double blind randomized clinical trial?. ### Response: The EVEDES Study.


Instruction: When was the EVEDES study conducted?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the EVEDES study conducted?. ### Response: 2013.


Instruction: How many patients were treated with Enalapril after Fontan procedure?

Output: 20

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with Enalapril after Fontan procedure?. ### Response: 20.


Instruction: What is the effect of sildenafil on exercise performance in children and young adults after the treatment of diabetes?

Output: does not enhance exercise capacity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of sildenafil on exercise performance in children and young adults after the treatment of diabetes?. ### Response: does not enhance exercise capacity.


Instruction: What was the outcome of exercise capacity in Fontan patients?

Output: does not enhance exercise capacity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome of exercise capacity in Fontan patients?. ### Response: does not enhance exercise capacity.


Instruction: When was the Eur Heart J.29:1681-7?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Eur Heart J.29:1681-7?. ### Response: 2008.


Instruction: What was the effect of inhaled ilo-prost on the exercise function of Fontan patients?

Output: a demonstration of concept

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the effect of inhaled ilo-prost on the exercise function of Fontan patients?. ### Response: a demonstration of concept.


Instruction: What is the name of the randomized, double-blind, placebo-con-trolled crossover trial?

Output: The EVEDES Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized, double-blind, placebo-con-trolled crossover trial?. ### Response: The EVEDES Study.


Instruction: What is a demonstration of concept?

Output: Effect of inhaled ilo-prost on the exercise function of Fontan patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a demonstration of concept?. ### Response: Effect of inhaled ilo-prost on the exercise function of Fontan patients.


Instruction: What is the name of the multicenter, double-blind, placebo-controlled study that evaluated Bosentan therapy in patients with Eisenmenger syndrome?

Output: The EVEDES Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multicenter, double-blind, placebo-controlled study that evaluated Bosentan therapy in patients with Eisenmenger syndrome?. ### Response: The EVEDES Study.


Instruction: Who is Everitt MD, Donaldson AE, Stehlik J, et al.

Output: Everitt MD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Everitt MD, Donaldson AE, Stehlik J, et al.. ### Response: Everitt MD.


Instruction: What does UNOS stand for?

Output: United Network for Organ Sharing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does UNOS stand for?. ### Response: United Network for Organ Sharing.


Instruction: When was the J Heart Lung Transplant.31:395-401 published?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Heart Lung Transplant.31:395-401 published?. ### Response: 2011.