Instruction: What should people wit h hear failure be discharged fr om hospital only when their clinical condition is stable and t he management plan is optimised?

Output: dischar

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should people wit h hear failure be discharged fr om hospital only when their clinical condition is stable and t he management plan is optimised?. ### Response: dischar.


Instruction: What should tak e into account t he wishes of the person and heir f amily or car er?

Output: Timing of dischar ge

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should tak e into account t he wishes of the person and heir f amily or car er?. ### Response: Timing of dischar ge.


Instruction: What should the primar y car e team tak e over routine management of chronic hear t failure in adult s?

Output: carr y out t he following f or people wit h hear t failure at all times

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should the primar y car e team tak e over routine management of chronic hear t failure in adult s?. ### Response: carr y out t he following f or people wit h hear t failure at all times.


Instruction: What is NG106?

Output: Chronic hear t failure in adult s: diagnosis and management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NG106?. ### Response: Chronic hear t failure in adult s: diagnosis and management.


Instruction: When is NICE 2023?

Output: All right s reserved

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is NICE 2023?. ### Response: All right s reserved.


Instruction: What is NICE 2023?

Output: diagnosis and management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE 2023?. ### Response: diagnosis and management.


Instruction: What is the Subject t o Notice of right s?

Output: All right s reserved

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Subject t o Notice of right s?. ### Response: All right s reserved.


Instruction: What is no longer available?

Output: penicillins and methicillin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is no longer available?. ### Response: penicillins and methicillin.


Instruction: What is the standard of care for methicillin-susceptible S aureus endocarditis?

Output: a semisynthetic, β-lactamase–resistant penicillin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the standard of care for methicillin-susceptible S aureus endocarditis?. ### Response: a semisynthetic, β-lactamase–resistant penicillin.


Instruction: What is a semisynthetic, -lactamase-resistant penicillin known as?

Output: nafcillin or oxacillin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a semisynthetic, -lactamase-resistant penicillin known as?. ### Response: nafcillin or oxacillin.


Instruction: How long does it take to give penicillin intravenously?

Output: 4 to 6 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take to give penicillin intravenously?. ### Response: 4 to 6 weeks.


Instruction: What is an option for the first 3 to 5 days?

Output: gentamicin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an option for the first 3 to 5 days?. ### Response: gentamicin.


Instruction: What is an option and may accelerate the killing of staphylococci?

Output: 3 to 5 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an option and may accelerate the killing of staphylococci?. ### Response: 3 to 5 days.


Instruction: What is based on extrapolation from experimental models?

Output: 3 to 5 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is based on extrapolation from experimental models?. ### Response: 3 to 5 days.


Instruction: In patients without a history of type 1 penicillin allergic reactions, what is an alternative?

Output: a first-generation cephalosporin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients without a history of type 1 penicillin allergic reactions, what is an alternative?. ### Response: a first-generation cephalosporin.


Instruction: What is an alternative for patients unable to tolerate -lactam antibiotic drugs?

Output: vancomycin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an alternative for patients unable to tolerate -lactam antibiotic drugs?. ### Response: vancomycin.


Instruction: How long is vancomycin for a minimum of 6 weeks?

Output: 3 to 5 days of therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is vancomycin for a minimum of 6 weeks?. ### Response: 3 to 5 days of therapy.


Instruction: What are staphylococcal strains?

Output: methicillin resistant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are staphylococcal strains?. ### Response: methicillin resistant.


Instruction: What is an alternative to days of therapy?

Output: gentamicin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an alternative to days of therapy?. ### Response: gentamicin.


Instruction: Some staphylococcal strains may be what?

Output: methicillin resistant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Some staphylococcal strains may be what?. ### Response: methicillin resistant.


Instruction: Patients with IE should not receive nafcillin, oxacillin, or what else?

Output: cephalosporin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with IE should not receive nafcillin, oxacillin, or what else?. ### Response: cephalosporin.


Instruction: Antibi-otic susceptibility results indicate that what is methicillin-resistant?

Output: S aureus endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Antibi-otic susceptibility results indicate that what is methicillin-resistant?. ### Response: S aureus endocarditis.


Instruction: What is not considered to be useful in meth-icillin-resistant staphylococcal endocarditis?

Output: cephalosporins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not considered to be useful in meth-icillin-resistant staphylococcal endocarditis?. ### Response: cephalosporins.


Instruction: What is the consen-sus of the writing?

Output: patients with S aureus endocardi-tis should be cared for in a medical facility with cardiothoracic surgery capabilities and infectious diseases consultation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the consen-sus of the writing?. ### Response: patients with S aureus endocardi-tis should be cared for in a medical facility with cardiothoracic surgery capabilities and infectious diseases consultation.


Instruction: What is the consen-sus of the writing group that patients with S aureus endocarditis should be cared for in a medical facility with cardiothoracic surgery capabilities and infectious diseases consultation?

Output: endocarditis may be treated with vancomycin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the consen-sus of the writing group that patients with S aureus endocarditis should be cared for in a medical facility with cardiothoracic surgery capabilities and infectious diseases consultation?. ### Response: endocarditis may be treated with vancomycin.


Instruction: Decisions about outpatient therapy may be individualized on the basis of what?

Output: clinical impression of symptom-atic recovery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Decisions about outpatient therapy may be individualized on the basis of what?. ### Response: clinical impression of symptom-atic recovery.


Instruction: What may be individualized on the basis of clinical impression of symptomatic recovery?

Output: outpatient therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be individualized on the basis of clinical impression of symptomatic recovery?. ### Response: outpatient therapy.


Instruction: What is the current standard of care for methicillin-susceptible S aureus endocarditis involv-ing a native valve?

Output: a semisynthetic, β-lactamase–resistant penicillin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the current standard of care for methicillin-susceptible S aureus endocarditis involv-ing a native valve?. ### Response: a semisynthetic, β-lactamase–resistant penicillin.


Instruction: What is methicillin-susceptible S aureus endocarditis involv-ing a native valve or other native cardiac tissue?

Output: a semisynthetic, β-lactamase–resistant penicillin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is methicillin-susceptible S aureus endocarditis involv-ing a native valve or other native cardiac tissue?. ### Response: a semisynthetic, β-lactamase–resistant penicillin.


Instruction: What is semisynthetic,  -lactamase-resistant peni-cillin?

Output: nafcillin or oxacillin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is semisynthetic,  -lactamase-resistant peni-cillin?. ### Response: nafcillin or oxacillin.


Instruction: How long is nafcilin or oxacillin given intravenously?

Output: 4 to 6 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is nafcilin or oxacillin given intravenously?. ### Response: 4 to 6 weeks.


Instruction: What is a class I; Level of Evidence A?

Output: methicillin-susceptible S aureus endocarditis involv-ing a native valve or other native cardiac tissue, which includes a semisynthetic, β -lactamase–resistant peni-cillin (nafcillin or oxacillin) given intravenously for a minimum of 4 to 6 weeks, assuming there has been an appropriate microbiological and clinical response to therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a class I; Level of Evidence A?. ### Response: methicillin-susceptible S aureus endocarditis involv-ing a native valve or other native cardiac tissue, which includes a semisynthetic, β -lactamase–resistant peni-cillin (nafcillin or oxacillin) given intravenously for a minimum of 4 to 6 weeks, assuming there has been an appropriate microbiological and clinical response to therapy.


Instruction: What may be considered to accelerate the killing of staphylococci?

Output: 3 to 5 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered to accelerate the killing of staphylococci?. ### Response: 3 to 5 days.


Instruction: What increases the likelihood of renal and otic toxicity?

Output: Addition of gentamicin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What increases the likelihood of renal and otic toxicity?. ### Response: Addition of gentamicin.


Instruction: What is the Class IIb; Level of Evidence C?

Output: gentamicin increases the likelihood of renal and otic toxicity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Class IIb; Level of Evidence C?. ### Response: gentamicin increases the likelihood of renal and otic toxicity.


Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020?

Output: Page 27 of 127 studies  evaluated were hetero geneous in type and dose of statin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020?. ### Response: Page 27 of 127 studies  evaluated were hetero geneous in type and dose of statin.


Instruction: How many studies evaluated were hetero geneous in type and dose of statin?

Output: 127

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies evaluated were hetero geneous in type and dose of statin?. ### Response: 127.


Instruction: What did Yebyo et al. find in a systematic review of primary prevention trials?

Output: discontinuation of statins for adverse effects was not different than placebo but there was a higher risk for myopathy, hepatic enzyme elevation , and renal dysfunction with statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Yebyo et al. find in a systematic review of primary prevention trials?. ### Response: discontinuation of statins for adverse effects was not different than placebo but there was a higher risk for myopathy, hepatic enzyme elevation , and renal dysfunction with statins.


Instruction: What was a higher risk of myopathy, hepatic enzyme elevation, and renal dysfunction with statins?

Output: discontinuation of statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a higher risk of myopathy, hepatic enzyme elevation, and renal dysfunction with statins?. ### Response: discontinuation of statins.


Instruction: What may be a risk of liver enzyme elevation and myopathy with statins?

Output: appear s inconsistent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be a risk of liver enzyme elevation and myopathy with statins?. ### Response: appear s inconsistent.


Instruction: What does LFT stand for?

Output: liver function testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does LFT stand for?. ### Response: liver function testing.


Instruction: What is there no recommendation for after initiation of LFT?

Output: routine testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is there no recommendation for after initiation of LFT?. ### Response: routine testing.


Instruction: How long is the optimal duration of statin therapy?

Output: six years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the optimal duration of statin therapy?. ### Response: six years.


Instruction: How long is the duration of statins unknown?

Output: six years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the duration of statins unknown?. ### Response: six years.


Instruction: What did Nayak et al. show after each trial?

Output: the proportion of patients taking statins after trial completion were nearly identical (w ithin 4%) between the previous statin and control populations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Nayak et al. show after each trial?. ### Response: the proportion of patients taking statins after trial completion were nearly identical (w ithin 4%) between the previous statin and control populations.


Instruction: How much was the difference between the statin and control populations?

Output: 4%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much was the difference between the statin and control populations?. ### Response: 4%).


Instruction: How much difference did the previous statin and control populations have?

Output: 4%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much difference did the previous statin and control populations have?. ### Response: 4%).


Instruction: What did the long- term follow-up studies show?

Output: the continuing advantage of the initial study period

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the long- term follow-up studies show?. ### Response: the continuing advantage of the initial study period.


Instruction: Who wrote a systematic review of the study?

Output: De Vera et al.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote a systematic review of the study?. ### Response: De Vera et al..


Instruction: How long did a systematic review by De Vera et al. (2014) suggest a significant reduction in MI with continuous statin use versus non- continuous use?

Output: two years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did a systematic review by De Vera et al. (2014) suggest a significant reduction in MI with continuous statin use versus non- continuous use?. ### Response: two years.


Instruction: What is the Scope of this Clinical Practice Guideline?

Output: the CPG applies to patients aged 40 years or older

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Scope of this Clinical Practice Guideline?. ### Response: the CPG applies to patients aged 40 years or older.


Instruction: What does the CPG apply to?

Output: patients aged 40 years or older

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the CPG apply to?. ### Response: patients aged 40 years or older.


Instruction: What is the minimum age for risk calculators?

Output: 40 years old

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the minimum age for risk calculators?. ### Response: 40 years old.


Instruction: What age does the Work Group understand there are conditions to consider for primary prevention treatment at younger ages?

Output: 40 years old

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What age does the Work Group understand there are conditions to consider for primary prevention treatment at younger ages?. ### Response: 40 years old.


Instruction: What may suggest a familial hyperlipidemic condition?

Output: severely elevated LDL -C levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may suggest a familial hyperlipidemic condition?. ### Response: severely elevated LDL -C levels.


Instruction: Why is there no direct evidence to guide providers?

Output: These cases are challenging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is there no direct evidence to guide providers?. ### Response: These cases are challenging.


Instruction: What is the only recommended strategy for patients over 40 who are interested in lipid testing and management?

Output: shared decision making about  the uncertain benefit and risks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the only recommended strategy for patients over 40 who are interested in lipid testing and management?. ### Response: shared decision making about  the uncertain benefit and risks.


Instruction: Several observational points can inform this decision but are not sufficient for what?

Output: an evidence -based recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Several observational points can inform this decision but are not sufficient for what?. ### Response: an evidence -based recommendation.


Instruction: Cardiovascular events and mortality are very low in what age group?

Output: under 40

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cardiovascular events and mortality are very low in what age group?. ### Response: under 40.


Instruction: Even observational studies of FH do not suggest what type of treatment is necessary?

Output: Cardiovascular

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Even observational studies of FH do not suggest what type of treatment is necessary?. ### Response: Cardiovascular.


Instruction: A French registry of HeFH is based in what country?

Output: French

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A French registry of HeFH is based in what country?. ### Response: French.


Instruction: How many people in France had a lifetime history of MI, stroke, or PAD?

Output: 7%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people in France had a lifetime history of MI, stroke, or PAD?. ### Response: 7%.


Instruction: How much of the French registry had revascularization?

Output: 4%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the French registry had revascularization?. ### Response: 4%.


Instruction: Who published the 2018 Cholesterol Clinical Practice Guidelines?

Output: Grundy et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2018 Cholesterol Clinical Practice Guidelines?. ### Response: Grundy et al.


Instruction: When did Grundy and colleagues publish the 2018 CHOLOSTERO CLINICAL STATEMENTS AND GUIDELINES?

Output: June 18/25, 2019

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Grundy and colleagues publish the 2018 CHOLOSTERO CLINICAL STATEMENTS AND GUIDELINES?. ### Response: June 18/25, 2019.


Instruction: What did Loprinzi PD and Addoh O do to predict all-cause and cardiovascular disease-specific mortality?

Output: Predictive validity of the American College of Cardiology/American Heart Association pooled cohort equa-tions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Loprinzi PD and Addoh O do to predict all-cause and cardiovascular disease-specific mortality?. ### Response: Predictive validity of the American College of Cardiology/American Heart Association pooled cohort equa-tions.


Instruction: What did Mortensen MB, Afzal S, Nordestgaard BG, et al. compare with risk-based approaches to guide statin therapy?

Output: ACC/AHA risk-based approach versus trial-based approaches

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Mortensen MB, Afzal S, Nordestgaard BG, et al. compare with risk-based approaches to guide statin therapy?. ### Response: ACC/AHA risk-based approach versus trial-based approaches.


Instruction: What was the name of the national prospective cohort study of adults in the United States?

Output: American College of Cardiology/American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the national prospective cohort study of adults in the United States?. ### Response: American College of Cardiology/American Heart Association.


Instruction: What is the difference between ACC/AHA and ESC/EAS guidelines for primary prevention with statins in non-diabetic Europeans?

Output: superior

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between ACC/AHA and ESC/EAS guidelines for primary prevention with statins in non-diabetic Europeans?. ### Response: superior.


Instruction: What was the Copenhagen General Population Study?

Output: statins in non-diabetic Europeans

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the Copenhagen General Population Study?. ### Response: statins in non-diabetic Europeans.


Instruction: What does MESA stand for?

Output: Multi-Ethnic Study of Atherosclerosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does MESA stand for?. ### Response: Multi-Ethnic Study of Atherosclerosis.


Instruction: What is the acronym for the Multi-Ethnic Study of Atherosclerosis?

Output: MESA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the Multi-Ethnic Study of Atherosclerosis?. ### Response: MESA.


Instruction: What is the name of the multiethnic population in which the ath-erosclerotic cardiovascular risk equation is accurate?

Output: Multi-Ethnic Study of Atherosclerosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multiethnic population in which the ath-erosclerotic cardiovascular risk equation is accurate?. ### Response: Multi-Ethnic Study of Atherosclerosis.


Instruction: When did the J Am Coll Cardiol. 201667:2118–30.

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the J Am Coll Cardiol. 201667:2118–30.. ### Response: 2016.


Instruction: What is a risk factor for car -diovascular disease in patients?

Output: sarcoidosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for car -diovascular disease in patients?. ### Response: sarcoidosis.


Instruction: What is the risk of car -diovascular disease in patients with sarcoidosis?

Output: estimate accurately

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of car -diovascular disease in patients with sarcoidosis?. ### Response: estimate accurately.


Instruction: What study predicts the 30-year risk of cardiovascular disease?

Output: Framingham Heart Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What study predicts the 30-year risk of cardiovascular disease?. ### Response: Framingham Heart Study.


Instruction: How long did the Framingham Heart Study last?

Output: 30-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the Framingham Heart Study last?. ### Response: 30-year.


Instruction: What is a risk factor burden at 50 years of age?

Output: Prediction of lifetime risk for cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor burden at 50 years of age?. ### Response: Prediction of lifetime risk for cardiovascular disease.


Instruction: What is the acronym for Risk-Enhancing Factors?

Output: S4.4.1.3-1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Risk-Enhancing Factors?. ### Response: S4.4.1.3-1.


Instruction: Where can you find the ASCVD Risk Predictor Plus?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find the ASCVD Risk Predictor Plus?. ### Response: http://tools.acc.org/ASCVD-Risk-Estimator-Plus/#!/calculate/estimate/..


Instruction: What is the ACC/AHA guideline on the treatment of blood cholesterol to reduce ath-erosclerotic cardiovascular risk in adults?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ACC/AHA guideline on the treatment of blood cholesterol to reduce ath-erosclerotic cardiovascular risk in adults?. ### Response: 2013.


Instruction: What is a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines?

Output: 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce ath-erosclerotic cardiovascular risk in adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines?. ### Response: 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce ath-erosclerotic cardiovascular risk in adults.


Instruction: What is the name of the Task Force on Practice Guidelines?

Output: American College of Cardiology/American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Practice Guidelines?. ### Response: American College of Cardiology/American Heart Association.


Instruction: When was the Circulation.129:S1–45. S4.4.1.3-3?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circulation.129:S1–45. S4.4.1.3-3?. ### Response: 2014.


Instruction: What is lowering cholesterol in intermediate-risk persons without cardiovascular disease?

Output: Cholesterol lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is lowering cholesterol in intermediate-risk persons without cardiovascular disease?. ### Response: Cholesterol lowering.


Instruction: Where is the N Engl J Med?

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the N Engl J Med?. ### Response: 2016.


Instruction: What does coro-nary artery calcium testing do for statin candidates?

Output: Implications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does coro-nary artery calcium testing do for statin candidates?. ### Response: Implications.


Instruction: How did the ERT coordinate the methodological and analytical processes of guideline development?

Output: grading the quality of the evidence per outcome, and grading thequality of the evidence for the recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did the ERT coordinate the methodological and analytical processes of guideline development?. ### Response: grading the quality of the evidence per outcome, and grading thequality of the evidence for the recommendations.


Instruction: What was grading the quality of the evidence per outcome?

Output: GRADE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was grading the quality of the evidence per outcome?. ### Response: GRADE.


Instruction: Who was responsible for writing the recommendations and underlyingrationale?

Output: The Work Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was responsible for writing the recommendations and underlyingrationale?. ### Response: The Work Group.


Instruction: Who graded the strength of the recommendation?

Output: The Work Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who graded the strength of the recommendation?. ### Response: The Work Group.


Instruction: Where did the ERT have a one-day meeting in February 2018?

Output: Houston, Texas,USA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where did the ERT have a one-day meeting in February 2018?. ### Response: Houston, Texas,USA.


Instruction: Where was the KDIGO Controversies Conference held in February 2018?

Output: Houston, Texas,USA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where was the KDIGO Controversies Conference held in February 2018?. ### Response: Houston, Texas,USA.


Instruction: What was the goal of the conference?

Output: to discuss the previous guideline and theﬁndings from the KDIGO Controversies Conference on BloodPressure in Chronic Kidney Disease,374andﬁnalize the guidelinedevelopment process

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the goal of the conference?. ### Response: to discuss the previous guideline and theﬁndings from the KDIGO Controversies Conference on BloodPressure in Chronic Kidney Disease,374andﬁnalize the guidelinedevelopment process.


Instruction: Who finalized the draftguideline topics and review topics?

Output: the Work Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who finalized the draftguideline topics and review topics?. ### Response: the Work Group.


Instruction: Who determined the overall scope of the guideline?

Output: The guideline Work Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who determined the overall scope of the guideline?. ### Response: The guideline Work Group.


Instruction: What did the KDIGO Controversies Confer-ence on Blood Pressure in CKD inform?

Output: A preliminarylist of topics and key clinical questions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the KDIGO Controversies Confer-ence on Blood Pressure in CKD inform?. ### Response: A preliminarylist of topics and key clinical questions.


Instruction: What was developed to present a visual representation of the clinical question?

Output: Logical frameworks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was developed to present a visual representation of the clinical question?. ### Response: Logical frameworks.


Instruction: What format did clinical questions adhere to?

Output: RCTs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What format did clinical questions adhere to?. ### Response: RCTs.


Instruction: What format was used to compile the list of critical and important outcomes?

Output: ICOM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What format was used to compile the list of critical and important outcomes?. ### Response: ICOM.


Instruction: Why were questions based on RCTs?

Output: to avoid bias by design

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why were questions based on RCTs?. ### Response: to avoid bias by design.


Instruction: Who voted on the list of critical and important outcomes?

Output: the Work Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who voted on the list of critical and important outcomes?. ### Response: the Work Group.


Instruction: Who refined the clinical questions to finalize inclusion and exclusioncriteria?

Output: The Work Group and the ERT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who refined the clinical questions to finalize inclusion and exclusioncriteria?. ### Response: The Work Group and the ERT.


Instruction: Clinicalquestions were mapped to existing what?

Output: Cochrane Kidney and Trans-plant systematic reviews

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Clinicalquestions were mapped to existing what?. ### Response: Cochrane Kidney and Trans-plant systematic reviews.


Instruction: What did not map with any Cochrane Kidney and Transplant systematic reviews?

Output: clinical questions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did not map with any Cochrane Kidney and Transplant systematic reviews?. ### Response: clinical questions.


Instruction: What was done for clinical questions that didn't map with a systematic review?

Output: de novo sys-tematic reviews

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was done for clinical questions that didn't map with a systematic review?. ### Response: de novo sys-tematic reviews.


Instruction: To ensure all identi fid studies were included in the evi-dence review, what guideline was reviewed?

Output: The previous guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: To ensure all identi fid studies were included in the evi-dence review, what guideline was reviewed?. ### Response: The previous guideline.


Instruction: What was included in the evi-dence review?

Output: all identi ﬁed studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was included in the evi-dence review?. ### Response: all identi ﬁed studies.


Instruction: What was conducted in accordance with the Cochrane Handbook?

Output: All evidence reviews

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was conducted in accordance with the Cochrane Handbook?. ### Response: All evidence reviews.


Instruction: How were all evidence reviews conducted?

Output: in accordance tothe Cochrane Handbook

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How were all evidence reviews conducted?. ### Response: in accordance tothe Cochrane Handbook.


Instruction: What did GRADE.384Literature searches and article selection do?

Output: guideline development adhered tothe standards

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did GRADE.384Literature searches and article selection do?. ### Response: guideline development adhered tothe standards.


Instruction: The Cochrane Kidney and Transplant Registry was searched for what?

Output: RCTs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The Cochrane Kidney and Transplant Registry was searched for what?. ### Response: RCTs.


Instruction: What is the first-line option for a variety of arrhythmias in pregnancy?

Output: Beta-adrenergic–blocking drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the first-line option for a variety of arrhythmias in pregnancy?. ### Response: Beta-adrenergic–blocking drugs.


Instruction: Why are beta-adrenergic-blocking drugs considered the first line option?

Output: because there are extensive reports on their safe use from treating a variety of maternal conditions over many decades

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why are beta-adrenergic-blocking drugs considered the first line option?. ### Response: because there are extensive reports on their safe use from treating a variety of maternal conditions over many decades.


Instruction: What would be less likely to cause hypotension?

Output: A slow infusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would be less likely to cause hypotension?. ### Response: A slow infusion.


Instruction: What may be reasonable for acute treatment in pregnant patients with SVT when adenosine and beta blockers are ineffective?

Output: Intravenous verapamil

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be reasonable for acute treatment in pregnant patients with SVT when adenosine and beta blockers are ineffective?. ### Response: Intravenous verapamil.


Instruction: What has been used effectively for the acute treatment of SVT in pregnant women?

Output: Intravenous verapamil

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been used effectively for the acute treatment of SVT in pregnant women?. ### Response: Intravenous verapamil.


Instruction: What is a higher risk of maternal hypotension with intravenous verapamil?

Output: there is a higher risk of maternal hypotension with intravenous verapamil than with adenosine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a higher risk of maternal hypotension with intravenous verapamil?. ### Response: there is a higher risk of maternal hypotension with intravenous verapamil than with adenosine.


Instruction: What is more limited than for acute SVT termination in pregnancy?

Output: diltiazem use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more limited than for acute SVT termination in pregnancy?. ### Response: diltiazem use.


Instruction: What may be reasonable for acute treatment in pregnant patients with SVT?

Output: Intravenous procainamide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be reasonable for acute treatment in pregnant patients with SVT?. ### Response: Intravenous procainamide.


Instruction: How has intravenous procainamide been used?

Output: safely to treat a variety of maternal and fetal supraventricular and ventricular arrhythmias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How has intravenous procainamide been used?. ### Response: safely to treat a variety of maternal and fetal supraventricular and ventricular arrhythmias.


Instruction: What can be used to treat a variety of maternal and fetal supraventricular and ventricular arrhythmias?

Output: Intravenous procainamide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be used to treat a variety of maternal and fetal supraventricular and ventricular arrhythmias?. ### Response: Intravenous procainamide.


Instruction: What is generally best avoided as long-term therapy because it can cause a lupus-like syndrome?

Output: ainamide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is generally best avoided as long-term therapy because it can cause a lupus-like syndrome?. ### Response: ainamide.


Instruction: Intravenous amiodarone is effective when used for what?

Output: acute treatment in pregnant patients with potentially life-threatening SVT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Intravenous amiodarone is effective when used for what?. ### Response: acute treatment in pregnant patients with potentially life-threatening SVT.


Instruction: What may be considered for acute treatment in pregnant patients with potentially life-threatening SVT when other therapies are ineffective or contraindicated?

Output: Intravenous amiodarone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered for acute treatment in pregnant patients with potentially life-threatening SVT when other therapies are ineffective or contraindicated?. ### Response: Intravenous amiodarone.


Instruction: What is an important concern during pregnancy?

Output: fetal hypothyroidism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an important concern during pregnancy?. ### Response: fetal hypothyroidism.


Instruction: How many cases of fetal hypothyroidism have been reported?

Output: 17%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many cases of fetal hypothyroidism have been reported?. ### Response: 17%.


Instruction: What is the most toxicities related to with intravenous infusion?

Output: cumulative drug dose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most toxicities related to with intravenous infusion?. ### Response: cumulative drug dose.


Instruction: What are most toxicities related to?

Output: cumulative drug dose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are most toxicities related to?. ### Response: cumulative drug dose.


Instruction: What can be effective for ongoing management in pregnant patients with highly symptomatic symptoms?

Output: The following drugs, alone or in combination

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be effective for ongoing management in pregnant patients with highly symptomatic symptoms?. ### Response: The following drugs, alone or in combination.


Instruction: What is effective for ongoing management in pregnant patients with highly symptomatic SVT?

Output: The following drugs, alone or in combination

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is effective for ongoing management in pregnant patients with highly symptomatic SVT?. ### Response: The following drugs, alone or in combination.


Instruction: What is a. Digoxin437,517 b. Flecainide437 c. Metoprolol517,521 d. Propafenone517 fr. Propranolol437 521 g. Verapamil517 what?

Output: Sotalol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a. Digoxin437,517 b. Flecainide437 c. Metoprolol517,521 d. Propafenone517 fr. Propranolol437 521 g. Verapamil517 what?. ### Response: Sotalol.


Instruction: What is BP lowering in isolated systolic hypertension effective in?

Output: reducing the risk of fatal and nonfatal stroke (primary outcome), cardiovascular events, and death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is BP lowering in isolated systolic hypertension effective in?. ### Response: reducing the risk of fatal and nonfatal stroke (primary outcome), cardiovascular events, and death.


Instruction: What is the primary outcome of RCTs?

Output: nonfatal stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary outcome of RCTs?. ### Response: nonfatal stroke.


Instruction: What is the primary outcome of antihypertensive treatment in older adults?

Output: nonfatal stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary outcome of antihypertensive treatment in older adults?. ### Response: nonfatal stroke.


Instruction: What is a challenge in treating elevated BP in older persons because of a high BP?

Output: heterogeneity in comorbidity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a challenge in treating elevated BP in older persons because of a high BP?. ### Response: heterogeneity in comorbidity.


Instruction: Why is BP in older persons challenging?

Output: high degree of heterogeneity in comorbidity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is BP in older persons challenging?. ### Response: high degree of heterogeneity in comorbidity.


Instruction: How many decades have RCTs of antihypertensive therapy included large numbers of older persons?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many decades have RCTs of antihypertensive therapy included large numbers of older persons?. ### Response: 3.


Instruction: What did more intensive treatment reduce the risk of for people over the age of 65, 75, and 80 years?

Output: CVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did more intensive treatment reduce the risk of for people over the age of 65, 75, and 80 years?. ### Response: CVD.


Instruction: What is HYVET?

Output: Hypertension in the Very Elderly Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is HYVET?. ### Response: Hypertension in the Very Elderly Trial.


Instruction: What did HYVET and SPRINT include?

Output: those who were frail but still living independently in the community

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did HYVET and SPRINT include?. ### Response: those who were frail but still living independently in the community.


Instruction: What was the time period between HYVET and SPRIINT?

Output: 1.8 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the time period between HYVET and SPRIINT?. ### Response: 1.8 years.


Instruction: How long did SPIINT take to stop?

Output: 3.26 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did SPIINT take to stop?. ### Response: 3.26 years.


Instruction: When did HYVET end?

Output: 1.8 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did HYVET end?. ### Response: 1.8 years.


Instruction: What is one of the few interventions shown to reduce mortality risk in frail older indi-viduals?

Output: BP-lowering therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the few interventions shown to reduce mortality risk in frail older indi-viduals?. ### Response: BP-lowering therapy.


Instruction: RCTs in noninstitutionalized community-dwelling older persons have shown that improved BP con-trol does not exacerbate orthostatic hypotension and has no adverse impact on risk of injurious falls?

Output: i-viduals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: RCTs in noninstitutionalized community-dwelling older persons have shown that improved BP con-trol does not exacerbate orthostatic hypotension and has no adverse impact on risk of injurious falls?. ### Response: i-viduals.


Instruction: What is the risk of injurious falls?

Output: orthostatic hypotension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of injurious falls?. ### Response: orthostatic hypotension.


Instruction: What excluded those with low standing BP on study entry?

Output: SPRINT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What excluded those with low standing BP on study entry?. ### Response: SPRINT.


Instruction: Older persons need to be carefully monitored for what during treatment?

Output: orthostatic hypotension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Older persons need to be carefully monitored for what during treatment?. ### Response: orthostatic hypotension.


Instruction: What is the risk of acute kidney injury seen in older adults?

Output: Intensive BP control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of acute kidney injury seen in older adults?. ### Response: Intensive BP control.


Instruction: What are the BP-lowering goals during antihypertensive care?

Output: those selected for persons <65 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the BP-lowering goals during antihypertensive care?. ### Response: those selected for persons <65 years of age.


Instruction: What does BP-lowering goals during antihypertensive treatment need not differ from?

Output: those selected for persons <65 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does BP-lowering goals during antihypertensive treatment need not differ from?. ### Response: those selected for persons <65 years of age.


Instruction: No randomized trial of BP lowering in persons >65 years of age has shown harm or less benefit for whom?

Output: older versus younger adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No randomized trial of BP lowering in persons >65 years of age has shown harm or less benefit for whom?. ### Response: older versus younger adults.


Instruction: What should clinicians implement in persons with high comorbidity burden?

Output: careful titra-tion of BP lowering and monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should clinicians implement in persons with high comorbidity burden?. ### Response: careful titra-tion of BP lowering and monitoring.


Instruction: Large RCTs have excluded older persons at any age who live in what?

Output: nursing homes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Large RCTs have excluded older persons at any age who live in what?. ### Response: nursing homes.


Instruction: What is recommended in all adults with hypertension?

Output: ASCVD risk assessment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended in all adults with hypertension?. ### Response: ASCVD risk assessment.


Instruction: What does ASCVD risk assessment include?

Output: older persons

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ASCVD risk assessment include?. ### Response: older persons.


Instruction: What is a chronic heart failure glossary?

Output: Chronic Heart Failure  Glossary  © NICE 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a chronic heart failure glossary?. ### Response: Chronic Heart Failure  Glossary  © NICE 2018.


Instruction: What is the Term Definition of the decision-making process?

Output: it is no t supposed to replace the judgement of healthcare professionals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Term Definition of the decision-making process?. ### Response: it is no t supposed to replace the judgement of healthcare professionals.


Instruction: How many types of economic evaluation are there?

Output: several

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many types of economic evaluation are there?. ### Response: several.


Instruction: How do economic evaluations differ from cost –benefit analysis?

Output: differ in the way they estimate the benefits of a particular drug, programme or intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do economic evaluations differ from cost –benefit analysis?. ### Response: differ in the way they estimate the benefits of a particular drug, programme or intervention.


Instruction: How do they estimate the benefits of a particular drug, programme or intervention?

Output: Efficacy  How beneficial a test, treatment or public health intervention is under ideal conditions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do they estimate the benefits of a particular drug, programme or intervention?. ### Response: Efficacy  How beneficial a test, treatment or public health intervention is under ideal conditions.


Instruction: What measure shows the magnitude of the outcome in one group compared with that in a control group?

Output: Effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What measure shows the magnitude of the outcome in one group compared with that in a control group?. ### Response: Effect.


Instruction: What is the effect size if the absolute risk reduction is shown to be 5% and it is the outcome of interest?

Output: 5%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect size if the absolute risk reduction is shown to be 5% and it is the outcome of interest?. ### Response: 5%..


Instruction: What is usually tested using statistics to find out how likely it is that an effect size will occur?

Output: The effect size

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is usually tested using statistics to find out how likely it is that an effect size will occur?. ### Response: The effect size.


Instruction: What is the purpose of statistics?

Output: to find out  how likely it is that the effect is a result of the treatment and has not just happened by chance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of statistics?. ### Response: to find out  how likely it is that the effect is a result of the treatment and has not just happened by chance.


Instruction: What is it to find out if the effect is a result of the treatment and has not happened by chance?

Output: The effect size is usually tested, using statistics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is it to find out if the effect is a result of the treatment and has not happened by chance?. ### Response: The effect size is usually tested, using statistics.


Instruction: How beneficial a test, treatment, or public health intervention is under ideal conditions?

Output: Efficacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How beneficial a test, treatment, or public health intervention is under ideal conditions?. ### Response: Efficacy.


Instruction: What is compared with doing nothing or opting for another type of care?

Output: Efficacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is compared with doing nothing or opting for another type of care?. ### Response: Efficacy.


Instruction: What is the term for a study of a disease within a population?

Output: Epidemiological study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for a study of a disease within a population?. ### Response: Epidemiological study.


Instruction: What does EQ-5D stand for?

Output: EuroQol 5 dimensions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does EQ-5D stand for?. ### Response: EuroQol 5 dimensions.


Instruction: What is the standardised instrument used to measure health -related quality of life?

Output: EQ-5D

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the standardised instrument used to measure health -related quality of life?. ### Response: EQ-5D.


Instruction: How is evidence obtained?

Output: from a range of sources including randomised controlled trials, observ ational studies, expert opinion (of clinical professionals or patients).

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is evidence obtained?. ### Response: from a range of sources including randomised controlled trials, observ ational studies, expert opinion (of clinical professionals or patients)..


Instruction: What is excluded from consideration as potential sources of evidence?

Output: studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is excluded from consideration as potential sources of evidence?. ### Response: studies.


Instruction: What are the criteria that define who is not eligible to participate in a clinical study?

Output: Exclusion criteria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the criteria that define who is not eligible to participate in a clinical study?. ### Response: Exclusion criteria.


Instruction: Option A is both more clinically effective than what?

Output: Option B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Option A is both more clinically effective than what?. ### Response: Option B.


Instruction: What option has a lower cost per unit of effect than Option B?

Output: Option A

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What option has a lower cost per unit of effect than Option B?. ### Response: Option A.


Instruction: Option A is said to have extended dominance over what option?

Output: Option B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Option A is said to have extended dominance over what option?. ### Response: Option B.


Instruction: What is an assumption that the results of studies of a specific population will a lso hold true for another population with similar characteristics?

Output: Extrapolation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an assumption that the results of studies of a specific population will a lso hold true for another population with similar characteristics?. ### Response: Extrapolation.


Instruction: What is observation over a period of time of an individual, group or initially defined?

Output: Follow -up

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is observation over a period of time of an individual, group or initially defined?. ### Response: Follow -up.


Instruction: S1.4-1. Baigent C, Blackwell L, Emberson J, et al. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials.

Output: Baigent C, Blackwell L, Emberson J, et al. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials. Lancet. 2010;376:1670–81

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: S1.4-1. Baigent C, Blackwell L, Emberson J, et al. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials.. ### Response: Baigent C, Blackwell L, Emberson J, et al. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials. Lancet. 2010;376:1670–81.


Instruction: S1.4-2. Chou R, Dana T, Blazina I, and others. Statin use for the prevention of what disease?

Output: car -diovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: S1.4-2. Chou R, Dana T, Blazina I, and others. Statin use for the prevention of what disease?. ### Response: car -diovascular disease.


Instruction: What is the purpose of statins for the prevention of car -diovascular disease in adults?

Output: primary prevention of cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of statins for the prevention of car -diovascular disease in adults?. ### Response: primary prevention of cardiovascular disease.


Instruction: Where is the US Agency for Healthcare Research and Quality located?

Output: Rockville, MD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the US Agency for Healthcare Research and Quality located?. ### Response: Rockville, MD.


Instruction: Who is the author of the systematic review for the US Preventive Services Task Force?

Output: Chou

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of the systematic review for the US Preventive Services Task Force?. ### Response: Chou.


Instruction: What are statins for the primary prevention of?

Output: cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are statins for the primary prevention of?. ### Response: cardiovascular disease.


Instruction: What is the 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atheroscle-rotic cardiovascular risk in adults?

Output: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atheroscle-rotic cardiovascular risk in adults?. ### Response: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.


Instruction: What is atheroscle-rotic cardiovascular risk in adults?

Output: reduce

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is atheroscle-rotic cardiovascular risk in adults?. ### Response: reduce.


Instruction: What is class of recommendation and level of evidence S1.5-1?

Output: S1–45.1.5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is class of recommendation and level of evidence S1.5-1?. ### Response: S1–45.1.5.


Instruction: What did the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines report on?

Output: Further evolution of the ACC/AHA clinical practice guideline recommendation classification system

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines report on?. ### Response: Further evolution of the ACC/AHA clinical practice guideline recommendation classification system.


Instruction: What was the name of the group that developed the ACC/AHA clinical practice guideline classification system?

Output: American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the group that developed the ACC/AHA clinical practice guideline classification system?. ### Response: American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.


Instruction: Cholesterol, LDL-C, and ASCVD S2.1.2-1?

Output: 1.2. Cholesterol, LDL-C, and ASCVD S2.1.2-1. Stamler J, Wentworth D, Neaton JD. Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cholesterol, LDL-C, and ASCVD S2.1.2-1?. ### Response: 1.2. Cholesterol, LDL-C, and ASCVD S2.1.2-1. Stamler J, Wentworth D, Neaton JD. Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded.


Instruction: What is the relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded?

Output: Stamler J, Wentworth D, Neaton JD. Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356 222 primary screenees of the Multiple Risk Factor Intervention Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded?. ### Response: Stamler J, Wentworth D, Neaton JD. Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356 222 primary screenees of the Multiple Risk Factor Intervention Trial.


Instruction: How many primary screenees of the Multiple Risk Factor Intervention Trial were included in the MRFIT trial?

Output: 356 222

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many primary screenees of the Multiple Risk Factor Intervention Trial were included in the MRFIT trial?. ### Response: 356 222.


Instruction: What is MRFIT?

Output: Multiple Risk Factor Intervention Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is MRFIT?. ### Response: Multiple Risk Factor Intervention Trial.


Instruction: What is the name of the study that examined serum cholesterol, lipopro-teins, and the risk of coronary heart disease?

Output: Framingham study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined serum cholesterol, lipopro-teins, and the risk of coronary heart disease?. ### Response: Framingham study.


Instruction: Cholesterol is a major risk factor for what type of disease?

Output: coronary heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cholesterol is a major risk factor for what type of disease?. ### Response: coronary heart disease.


Instruction: When was Comparative Quantification of Health Risks: Global and Regional Burden of Disease Attributed to Selected Major Risk Factors published?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Comparative Quantification of Health Risks: Global and Regional Burden of Disease Attributed to Selected Major Risk Factors published?. ### Response: 2004.


Instruction: Geneva, Switzerland: WHO, 391–496.

Output: World Health Organization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Geneva, Switzerland: WHO, 391–496.. ### Response: World Health Organization.


Instruction: What is ezetimibe added to statin therapy after acute coronary syndromes?

Output: Ezetimibe added to statin therapy after acute coronary syndromes. N Engl J Med

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ezetimibe added to statin therapy after acute coronary syndromes?. ### Response: Ezetimibe added to statin therapy after acute coronary syndromes. N Engl J Med.


Instruction: What is the name of the meta-analysis of statin trials?

Output: Very low levels of ath-erogenic lipoproteins and the risk for cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis of statin trials?. ### Response: Very low levels of ath-erogenic lipoproteins and the risk for cardiovascular events.


Instruction: What is statin therapy after acute coronary syndromes?

Output: Ezetimibe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is statin therapy after acute coronary syndromes?. ### Response: Ezetimibe.


Instruction: What is evolocumab and clini-cal outcomes in patients with cardiovascular disease?

Output: S2.1.2-7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is evolocumab and clini-cal outcomes in patients with cardiovascular disease?. ### Response: S2.1.2-7.


Instruction: Who is Silverman MG?

Output: Ference BA, Im K

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Silverman MG?. ### Response: Ference BA, Im K.


Instruction: What is the association between lower -ing LDL-C and cardiovascular risk reduction among different thera- teria?

Output: Efficacy and safety

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association between lower -ing LDL-C and cardiovascular risk reduction among different thera- teria?. ### Response: Efficacy and safety.


Instruction: What does BA, Im K, and Im K do?

Output: Association between lower -ing LDL-C and cardiovascular risk reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does BA, Im K, and Im K do?. ### Response: Association between lower -ing LDL-C and cardiovascular risk reduction.


Instruction: How does self management of oral anticoagulation therapy improve quality of life and anxiety?

Output: effects on treatment-related quality of life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does self management of oral anticoagulation therapy improve quality of life and anxiety?. ### Response: effects on treatment-related quality of life.


Instruction: What is Murray E, Fitzmaurice D, Fuller C, Sandhur H. Training for patients in a randomised controlled trial of self-management of warfarin?

Output: Does self-management of oral anticoagulation therapy improve quality of life and anxie ty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Murray E, Fitzmaurice D, Fuller C, Sandhur H. Training for patients in a randomised controlled trial of self-management of warfarin?. ### Response: Does self-management of oral anticoagulation therapy improve quality of life and anxie ty.


Instruction: What is the name of the randomised controlled trial of self management of warfarin?

Output: SPOG 60 1Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised controlled trial of self management of warfarin?. ### Response: SPOG 60 1Study Group.


Instruction: When was the BMJ 328(7437):437-438.72?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the BMJ 328(7437):437-438.72?. ### Response: 2004.


Instruction: Who was the SPOG 60 1Study Group?

Output: Siebenhofer A, Hemkens LG, Rakovac I, Spat S, Didjurgeit U

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the SPOG 60 1Study Group?. ### Response: Siebenhofer A, Hemkens LG, Rakovac I, Spat S, Didjurgeit U.


Instruction: What did self-management of oral anticoagulation in elderly patients effect on?

Output: treatment-related quality of life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did self-management of oral anticoagulation in elderly patients effect on?. ### Response: treatment-related quality of life.


Instruction: How does self-management of oral anticoagulation reduce majoroutcomes in the elderly?

Output: effects on treatment-related quality of life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does self-management of oral anticoagulation reduce majoroutcomes in the elderly?. ### Response: effects on treatment-related quality of life.


Instruction: When did Thromb Haemost. 2008,100(6):1089-1098.74?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Thromb Haemost. 2008,100(6):1089-1098.74?. ### Response: 2008.


Instruction: What is the cost-effectiveness of self-managed versus physician managed?

Output: Cost-effectiveness of self-managed versus physician-managed oral anticoagulation therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cost-effectiveness of self-managed versus physician managed?. ### Response: Cost-effectiveness of self-managed versus physician-managed oral anticoagulation therapy.


Instruction: What is the cost-effectiveness of self-managed versus physician managed oral anticoagulation therapy?

Output: improve quality of life and anxie ty?Fam Pract . 2011;28(2):134-140.71. Murray E, Fitzmaurice D, McCahon D, Fuller C, Sandhur H. Training for patients in a randomised controlled trial of self management of warfarin trea tment.BMJ. 2004;328(7437):437-438.72. Siebenhofer A, Hemkens LG, Rakovac I, Spat S, Didjurgeit U; SPOG 60 1Study Group. Self-management of oral anticoagulation in elderly patients -effects on treatment-related quality of life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cost-effectiveness of self-managed versus physician managed oral anticoagulation therapy?. ### Response: improve quality of life and anxie ty?Fam Pract . 2011;28(2):134-140.71. Murray E, Fitzmaurice D, McCahon D, Fuller C, Sandhur H. Training for patients in a randomised controlled trial of self management of warfarin trea tment.BMJ. 2004;328(7437):437-438.72. Siebenhofer A, Hemkens LG, Rakovac I, Spat S, Didjurgeit U; SPOG 60 1Study Group. Self-management of oral anticoagulation in elderly patients -effects on treatment-related quality of life.


Instruction: When did CMAJ publish a 174(13):1847-1852.75?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did CMAJ publish a 174(13):1847-1852.75?. ### Response: 2006.


Instruction: What was the name of the study that evaluated the cost effectiveness of patient self-management?

Output: SPOG 60 1Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the study that evaluated the cost effectiveness of patient self-management?. ### Response: SPOG 60 1Study Group.


Instruction: What is a quality indicator foranticoagulation care?

Output: Prompt repeat testing after out-of-range INR values

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a quality indicator foranticoagulation care?. ### Response: Prompt repeat testing after out-of-range INR values.


Instruction: How many patients performed patient self-management of oral anticoagulation?

Output: 15 834

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients performed patient self-management of oral anticoagulation?. ### Response: 15 834.


Instruction: How many patients performed patient self-management of oral anticoagulation with vitamin K antagonists in real-life practice?

Output: 15 834

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients performed patient self-management of oral anticoagulation with vitamin K antagonists in real-life practice?. ### Response: 15 834.


Instruction: Who conducted the survey?

Output: International Self-Monitoring Association of OrallyAnticoagulated Patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who conducted the survey?. ### Response: International Self-Monitoring Association of OrallyAnticoagulated Patients.


Instruction: What is the name of the Italian Federation of Anticoagulation Clinics Clinical Quality Study Group?

Output: FCSA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Italian Federation of Anticoagulation Clinics Clinical Quality Study Group?. ### Response: FCSA.


Instruction: What does FCSA stand for?

Output: Italian Federation of Anticoagulation Clinics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does FCSA stand for?. ### Response: Italian Federation of Anticoagulation Clinics.


Instruction: What is the name of the FCSA Clinical Quality Study Group?

Output: Italian Federation of Anticoagulation Clinics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the FCSA Clinical Quality Study Group?. ### Response: Italian Federation of Anticoagulation Clinics.


Instruction: A comparison between six-week intervals in surveillance of oral antico agulanttreatment?

Output: reduces majorout

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A comparison between six-week intervals in surveillance of oral antico agulanttreatment?. ### Response: reduces majorout.


Instruction: How often does Warfarin dose assessment occur in patients with stable international normalized ratios?

Output: every 12 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often does Warfarin dose assessment occur in patients with stable international normalized ratios?. ### Response: every 12 weeks.


Instruction: What is the name of the randomized trial?

Output: SPOG 60 1Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized trial?. ### Response: SPOG 60 1Study Group.


Instruction: When was the last dose assessment?

Output: every 4 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last dose assessment?. ### Response: every 4 weeks.


Instruction: How long did the intervals in surveillance of oral antico agulanttreatment last?

Output: six- and four-week

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the intervals in surveillance of oral antico agulanttreatment last?. ### Response: six- and four-week.


Instruction: How long can intervals of measurement safely extend to?

Output: 14 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long can intervals of measurement safely extend to?. ### Response: 14 weeks.


Instruction: What is the purpose of warfarin anticoagulation therapy?

Output: stroke prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of warfarin anticoagulation therapy?. ### Response: stroke prevention.


Instruction: What is the interval between prothrombin time tests and the quality of oral anticoagulants treatment?

Output: six- and four-week

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the interval between prothrombin time tests and the quality of oral anticoagulants treatment?. ### Response: six- and four-week.


Instruction: What was not superior to drug therapy for the primary cardiovascular outcomes of death, disabling stroke, serious bleeding, or cardiac arrest at 5 years among patients with new-onset or un-treated AF that required therapy?

Output: AF ablation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not superior to drug therapy for the primary cardiovascular outcomes of death, disabling stroke, serious bleeding, or cardiac arrest at 5 years among patients with new-onset or un-treated AF that required therapy?. ### Response: AF ablation.


Instruction: What does Online Data Supplement 8.COR LOE RecommendationsI B-R1 do?

Output: Referenced studies that support new or modified recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Online Data Supplement 8.COR LOE RecommendationsI B-R1 do?. ### Response: Referenced studies that support new or modified recommendations.


Instruction: What is the risk score for systemic thromboembolism used for?

Output: 2 or greater

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk score for systemic thromboembolism used for?. ### Response: 2 or greater.


Instruction: What is recommended unless the bleeding risk exceeds the expected benefit?

Output: anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended unless the bleeding risk exceeds the expected benefit?. ### Response: anticoagulation.


Instruction: What was updated from C in the 2014 AF Guideline to B-R?

Output: LOE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was updated from C in the 2014 AF Guideline to B-R?. ### Response: LOE.


Instruction: What is recommended for patients with hemodynamic compromise, ongoing ischemia, or inadequate rate control?

Output: Urgent direct-current cardioversion of new-onset AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for patients with hemodynamic compromise, ongoing ischemia, or inadequate rate control?. ### Response: Urgent direct-current cardioversion of new-onset AF.


Instruction: What are intravenous beta blockers recommended to slow?

Output: a rapid ventricular response to AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are intravenous beta blockers recommended to slow?. ### Response: a rapid ventricular response to AF.


Instruction: What type of therapy is recommended to slow a rapid ventricular response to AF in patients with ACS who do not display HF, hemodynamic instability, or bronchospasm?

Output: Intravenous beta blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is recommended to slow a rapid ventricular response to AF in patients with ACS who do not display HF, hemodynamic instability, or bronchospasm?. ### Response: Intravenous beta blockers.


Instruction: What is recommended if triple therapy is prescribed for patients with acute AF at increased risk of stroke?

Output: double therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended if triple therapy is prescribed for patients with acute AF at increased risk of stroke?. ### Response: double therapy.


Instruction: What is PCI with stenting for ACS called?

Output: percutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PCI with stenting for ACS called?. ### Response: percutaneous coronary intervention.


Instruction: What is clopidogrel in preference to?

Output: prasugrel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is clopidogrel in preference to?. ### Response: prasugrel.


Instruction: Which drug is more likely to cause stroke in patients with AF?

Output: triple therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which drug is more likely to cause stroke in patients with AF?. ### Response: triple therapy.


Instruction: What is B-R5 in patients with AF at increased risk of stroke based on CHA2DS2-VASc risk score of 2 or greater?

Output: triple therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is B-R5 in patients with AF at increased risk of stroke based on CHA2DS2-VASc risk score of 2 or greater?. ### Response: triple therapy.


Instruction: What is clopidogrel or ticagrelor?

Output: P2Y12 inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is clopidogrel or ticagrelor?. ### Response: P2Y12 inhibitors.


Instruction: What is reasonable to reduce the risk of bleeding as compared with triple therapy?

Output: double therapy with P2Y12 inhibitors (clopidogrel) and low-dose rivaroxaban 15 mg daily

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable to reduce the risk of bleeding as compared with triple therapy?. ### Response: double therapy with P2Y12 inhibitors (clopidogrel) and low-dose rivaroxaban 15 mg daily.


Instruction: New RCT data and data from 2 registries and a retrospective cohort study are available.

Output: S7.4-3,S7.4-6–S7.4-8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: New RCT data and data from 2 registries and a retrospective cohort study are available.. ### Response: S7.4-3,S7.4-6–S7.4-8.


Instruction: What is low-dose rivaroxaban 15 mg daily?

Output: reasonable to reduce the risk of bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is low-dose rivaroxaban 15 mg daily?. ### Response: reasonable to reduce the risk of bleeding.


Instruction: What is the CHA2DS2-VASc risk score?

Output: 2 or greater

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the CHA2DS2-VASc risk score?. ### Response: 2 or greater.


Instruction: When will the new published data be available?

Output: April 23, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When will the new published data be available?. ### Response: April 23, 2023.


Instruction: What is the name of the new publication?

Output: IIa B-R5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the new publication?. ### Response: IIa B-R5.


Instruction: What do many clinicians perform with DESor BMS in cardiac transplant patients with discrete lesions with an abnormal stress test or symptoms suggestive ofmyocardial ischemia?

Output: stenting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do many clinicians perform with DESor BMS in cardiac transplant patients with discrete lesions with an abnormal stress test or symptoms suggestive ofmyocardial ischemia?. ### Response: stenting.


Instruction: When was e612 Circulated from http://ahajournals.org?

Output: December 6, 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was e612 Circulated from http://ahajournals.org?. ### Response: December 6, 2011.


Instruction: What does Selker HP say about systems for comparing actual and predicted mortality rates:characteristics to promote cooperation in improving hospital care?

Output: 780. Selker HP. Systems for comparing actual and predicted mortality rates:characteristics to promote cooperation in improving hospital care. AnnIntern Med. 1993;118:820–2.781

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Selker HP say about systems for comparing actual and predicted mortality rates:characteristics to promote cooperation in improving hospital care?. ### Response: 780. Selker HP. Systems for comparing actual and predicted mortality rates:characteristics to promote cooperation in improving hospital care. AnnIntern Med. 1993;118:820–2.781.


Instruction: What does Austin PC, Alter DA, Tu JV think about the use of fixed- and random-effectsmodels for classifying hospitals as?

Output: mortality outliers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Austin PC, Alter DA, Tu JV think about the use of fixed- and random-effectsmodels for classifying hospitals as?. ### Response: mortality outliers.


Instruction: Monte Carloassessment. Med Decis Making. 2003;23:526–39.782. Christiansen CL, Morris CN. Improving the statistical approach to health care provider profiling. 1997;127:764–8.783.

Output: The use of fixed- and random-effectsmodels for classifying hospitals as mortality outliers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Monte Carloassessment. Med Decis Making. 2003;23:526–39.782. Christiansen CL, Morris CN. Improving the statistical approach to health care provider profiling. 1997;127:764–8.783.. ### Response: The use of fixed- and random-effectsmodels for classifying hospitals as mortality outliers.