Instruction: What did the addition of a statin to existing treatments in high-risk patients result in?

Output: 24% reduction (95% CI, 19–28) in the rate of major CVD events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the addition of a statin to existing treatments in high-risk patients result in?. ### Response: 24% reduction (95% CI, 19–28) in the rate of major CVD events.


Instruction: A 22% reduction in major vascular events regardless of the presence of what?

Output: known coronary heart disease or cholesterol levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A 22% reduction in major vascular events regardless of the presence of what?. ### Response: known coronary heart disease or cholesterol levels.


Instruction: What did the Collaborative Atorvastatin Diabetes Study report?

Output: the primary outcome results were similar

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Collaborative Atorvastatin Diabetes Study report?. ### Response: the primary outcome results were similar.


Instruction: How much reduction in strokes were found among 5963 diabetic individu-als treated with statin in addition to best medical care?

Output: 24%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much reduction in strokes were found among 5963 diabetic individu-als treated with statin in addition to best medical care?. ### Response: 24%.


Instruction: What is the acronym for the Collaborative Atorvastatin Diabetes Study?

Output: CARDS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the Collaborative Atorvastatin Diabetes Study?. ### Response: CARDS.


Instruction: What did the CARDS report in patients with type 2 diabetes mellitus with at least 1 additional risk factor?

Output: an LDL cholesterol level <160 mg/dL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the CARDS report in patients with type 2 diabetes mellitus with at least 1 additional risk factor?. ### Response: an LDL cholesterol level <160 mg/dL.


Instruction: How much reduction did treatment with a statin result in?

Output: 48%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much reduction did treatment with a statin result in?. ### Response: 48%.


Instruction: How much reduction in stroke did statin treatment result in?

Output: 48%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much reduction in stroke did statin treatment result in?. ### Response: 48%.


Instruction: What was the 95% CI for stroke?

Output: 0.83–0.98

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 95% CI for stroke?. ### Response: 0.83–0.98.


Instruction: What drug is used to treat multifocal atrial tachycardia?

Output: amiodarone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug is used to treat multifocal atrial tachycardia?. ### Response: amiodarone.


Instruction: What is the name of the drug used in the treatment of multifacial atrial heart failure?

Output: amiodarone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used in the treatment of multifacial atrial heart failure?. ### Response: amiodarone.


Instruction: How many patients were treated with verapamil in 1987?

Output: 231

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with verapamil in 1987?. ### Response: 231.


Instruction: What is the effective treatment of multifocal atrial tachycardia with amiodarone?

Output: 231

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effective treatment of multifocal atrial tachycardia with amiodarone?. ### Response: 231.


Instruction: When did Jpn Heart J. 1989;30:301-12?

Output: 1989

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Jpn Heart J. 1989;30:301-12?. ### Response: 1989.


Instruction: What is the name of the drug that is used for treatment of multifacial atrial heart disease?

Output: amiodarone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug that is used for treatment of multifacial atrial heart disease?. ### Response: amiodarone.


Instruction: Where can verapamil be obtained?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can verapamil be obtained?. ### Response: http://ahajournals.org.


Instruction: What is the name of the journal that was published in 1987?

Output: South Med J

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that was published in 1987?. ### Response: South Med J.


Instruction: When was this article first published?

Output: April 23, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this article first published?. ### Response: April 23, 2023.


Instruction: What may cause hyperkalemia or a reversible decline in kidney function in patients with low eGFR?

Output: ACEi, ARB, and direct renin inhibitor(DRI) therapy in patients with CKD, with or without diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may cause hyperkalemia or a reversible decline in kidney function in patients with low eGFR?. ### Response: ACEi, ARB, and direct renin inhibitor(DRI) therapy in patients with CKD, with or without diabetes.


Instruction: What is the role of dual therapy with RASi?

Output: We recommend avoiding any combination of ACEi, ARB, and direct renin inhibitor(DRI) therapy in patients with CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of dual therapy with RASi?. ### Response: We recommend avoiding any combination of ACEi, ARB, and direct renin inhibitor(DRI) therapy in patients with CKD.


Instruction: What type of diabetes does 1B have?

Output: CKD, with or without diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diabetes does 1B have?. ### Response: CKD, with or without diabetes.


Instruction: What is the name of the organization that recommends a diabetic diet?

Output: kidney-international

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that recommends a diabetic diet?. ### Response: kidney-international.


Instruction: What is a relationship considered to be if it is less than significant under the preceding definition?

Output: modest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a relationship considered to be if it is less than significant under the preceding definition?. ### Response: modest.


Instruction: Relationships that exist with no financial benefit are also included for the purpose of what?

Output: transparency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Relationships that exist with no financial benefit are also included for the purpose of what?. ### Response: transparency.


Instruction: Names are listed in alphabetical order within each table.

Output: review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Names are listed in alphabetical order within each table.. ### Response: review.


Instruction: What is the acronym for American Association for Thoracic Surgery?

Output: AATS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for American Association for Thoracic Surgery?. ### Response: AATS.


Instruction: What does ACC stand for?

Output: American College of Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ACC stand for?. ### Response: American College of Cardiology.


Instruction: How are names listed in each category of review?

Output: in alphabetical order

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are names listed in each category of review?. ### Response: in alphabetical order.


Instruction: What is the acronym for American College of Cardiology?

Output: ACC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for American College of Cardiology?. ### Response: ACC.


Instruction: What is AHA?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is AHA?. ### Response: American Heart Association.


Instruction: AIG stands for Assembly of International Governors.

Output: AIG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: AIG stands for Assembly of International Governors.. ### Response: AIG.


Instruction: ASE stands for American Society of Echocardiography.

Output: ASE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ASE stands for American Society of Echocardiography.. ### Response: ASE.


Instruction: HRS stands for Heart Rhythm Society.

Output: HRS, Heart Rhythm Society

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: HRS stands for Heart Rhythm Society.. ### Response: HRS, Heart Rhythm Society.


Instruction: MAUDE stands for what?

Output: McGill Adult Unit for Congenital Heart Disease Excellence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: MAUDE stands for what?. ### Response: McGill Adult Unit for Congenital Heart Disease Excellence.


Instruction: What is the acronym for Adult Unit for Congenital Heart Disease Excellence?

Output: MAUDE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Adult Unit for Congenital Heart Disease Excellence?. ### Response: MAUDE.


Instruction: What is SCAI?

Output: Society for Cardiovascular Angiography and Interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SCAI?. ### Response: Society for Cardiovascular Angiography and Interventions.


Instruction: Where is STS located?

Output: Society of Thoracic Surgeons

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is STS located?. ### Response: Society of Thoracic Surgeons.


Instruction: When was the appendix downloaded?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the appendix downloaded?. ### Response: April 28, 2023.


Instruction: What is the therapeutic range of heparin for coronary indica-tions?

Output: unknown

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the therapeutic range of heparin for coronary indica-tions?. ### Response: unknown.


Instruction: What is more research needed to identify the optimal approach for monitoring?

Output: unfractionated heparin (UFH) therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more research needed to identify the optimal approach for monitoring?. ### Response: unfractionated heparin (UFH) therapy.


Instruction: What is the range of heparin for coronary indica-tions?

Output: unknown

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the range of heparin for coronary indica-tions?. ### Response: unknown.


Instruction: What is likely to correspond to 10% lower than those used for treatment of patients with VTE?

Output: heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is likely to correspond to 10% lower than those used for treatment of patients with VTE?. ### Response: heparin.


Instruction: The results of a ran-domized trial in patients with what disease showed that unmonitored weight-adjusted subcutaneous hepatic was given twice daily?

Output: VTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The results of a ran-domized trial in patients with what disease showed that unmonitored weight-adjusted subcutaneous hepatic was given twice daily?. ### Response: VTE.


Instruction: What is a term used to describe heparin resistance?

Output: Heparin Resistance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a term used to describe heparin resistance?. ### Response: Heparin Resistance.


Instruction: What did the study show was as safe and effic-tive as unmonitored, weight-adjusted LMWH?

Output: subcutaneous heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the study show was as safe and effic-tive as unmonitored, weight-adjusted LMWH?. ### Response: subcutaneous heparin.


Instruction: What is a term used to describe the situation where patients require unusually high doses of heparin to achieve a therapeutic aPTT?

Output: VTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a term used to describe the situation where patients require unusually high doses of heparin to achieve a therapeutic aPTT?. ### Response: VTE.


Instruction: What may cause drug-induced heparin resis-tance?

Output: Aprotinin and nitroglycerin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may cause drug-induced heparin resis-tance?. ### Response: Aprotinin and nitroglycerin.


Instruction: How many elevations in the levels of heparain-binding proteins?

Output: 38,87

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many elevations in the levels of heparain-binding proteins?. ### Response: 38,87.


Instruction: Aprotinin and nitroglycerin may cause what?

Output: heparin resis-tance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Aprotinin and nitroglycerin may cause what?. ### Response: heparin resis-tance.


Instruction: What is the association with nitroglycerin controversial?

Output: drug-induced heparin resis-tance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association with nitroglycerin controversial?. ### Response: drug-induced heparin resis-tance.


Instruction: What was the target range for anti-Xa levels?

Output: between 0.35-0.7 units/mL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the target range for anti-Xa levels?. ### Response: between 0.35-0.7 units/mL.


Instruction: What did randomized patients receive?

Output: lower doses of heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did randomized patients receive?. ### Response: lower doses of heparin.


Instruction: How did heparin doses compare to aPTT values?

Output: lower doses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did heparin doses compare to aPTT values?. ### Response: lower doses.


Instruction: What are the limits of heparin in addition to hemor-rhagic complications?

Output: pharmacokinetic properties

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the limits of heparin in addition to hemor-rhagic complications?. ### Response: pharmacokinetic properties.


Instruction: What is the ability to do with anti-Xa levels in patients with VTE?

Output: adjust heparin doses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ability to do with anti-Xa levels in patients with VTE?. ### Response: adjust heparin doses.


Instruction: What can lead to osteoporosis?

Output: bone metabolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can lead to osteoporosis?. ### Response: bone metabolism.


Instruction: What are some nonhemorrhagic side effects?

Output: skin reactions that can progress to necrosis, alopecia, and hypersen-sitivity reactions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some nonhemorrhagic side effects?. ### Response: skin reactions that can progress to necrosis, alopecia, and hypersen-sitivity reactions.


Instruction: Skin reactions that can progress to necrosis are examples of what?

Output: nonhemorrhagic side effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Skin reactions that can progress to necrosis are examples of what?. ### Response: nonhemorrhagic side effects.


Instruction: What are skin reactions that can progress to necrosis, alopecia, and hypersen-sitivity reactions?

Output: nonhemorrhagic side effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are skin reactions that can progress to necrosis, alopecia, and hypersen-sitivity reactions?. ### Response: nonhemorrhagic side effects.


Instruction: What are hypersensitivity reactions to heparin?

Output: uncommon

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are hypersensitivity reactions to heparin?. ### Response: uncommon.


Instruction: In 2007, an unusually high number of adverse events with what drug were reported in North America?

Output: heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In 2007, an unusually high number of adverse events with what drug were reported in North America?. ### Response: heparin.


Instruction: What was the cause of these reactions?

Output: Aprotinin and nitroglycerin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the cause of these reactions?. ### Response: Aprotinin and nitroglycerin.


Instruction: Where was the contaminant in heparin manufac-tured?

Output: China

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where was the contaminant in heparin manufac-tured?. ### Response: China.


Instruction: What was the contaminant in heparin manufac-tured in China?

Output: chondroitin sulfate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the contaminant in heparin manufac-tured in China?. ### Response: chondroitin sulfate.


Instruction: What is postulated that when given in therapeutic doses, the anticoagulant can be what?

Output: 94

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is postulated that when given in therapeutic doses, the anticoagulant can be what?. ### Response: 94.


Instruction: Asians vs non-Asians were compared for what?

Output: standard-dose NOACs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Asians vs non-Asians were compared for what?. ### Response: standard-dose NOACs.


Instruction: What were the effect sizes of the primary ef ficacy end point (stroke and systemicembolism) and the primary safety end point?

Output: greater

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the effect sizes of the primary ef ficacy end point (stroke and systemicembolism) and the primary safety end point?. ### Response: greater.


Instruction: What was the risk reduction in hemorrhagic stroke and gastrointestinalbleeding greater in Asians vs non-Asians?

Output: standard-dose NOACs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk reduction in hemorrhagic stroke and gastrointestinalbleeding greater in Asians vs non-Asians?. ### Response: standard-dose NOACs.


Instruction: What was more effective and safer for Asians when compared with warfarin?

Output: standard-dose NOACs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was more effective and safer for Asians when compared with warfarin?. ### Response: standard-dose NOACs.


Instruction: How many mg of rivaroxaban were used for low-dose NOACs?

Output: 20 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mg of rivaroxaban were used for low-dose NOACs?. ### Response: 20 mg.


Instruction: What are three low-dose NOACs?

Output: dabigatran 110 mg, rivaroxaban15 mg, and edoxaban 30 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are three low-dose NOACs?. ### Response: dabigatran 110 mg, rivaroxaban15 mg, and edoxaban 30 mg.


Instruction: What is rivaroxaban 15 mg/10 mg?

Output: low-dose NOACs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is rivaroxaban 15 mg/10 mg?. ### Response: low-dose NOACs.


Instruction: What is more commonly used than standard-dose NOACs?

Output: warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more commonly used than standard-dose NOACs?. ### Response: warfarin.


Instruction: What was associated with reduced risk of ischemic stroke or systemicembolization, major bleeding, ICH, and total mortality compared with warfarin?

Output: the use of NOACs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with reduced risk of ischemic stroke or systemicembolization, major bleeding, ICH, and total mortality compared with warfarin?. ### Response: the use of NOACs.


Instruction: Published data suggest thatNOACs are preferentially indicated for stroke prevention in what ethnicity?

Output: Asians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Published data suggest thatNOACs are preferentially indicated for stroke prevention in what ethnicity?. ### Response: Asians.


Instruction: What are NOACs better than than VKAs?

Output: serious bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are NOACs better than than VKAs?. ### Response: serious bleeding.


Instruction: What discourages initiation of anticoagulant therapy in patients at highrisk of bleeding?

Output: Thepotential for bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What discourages initiation of anticoagulant therapy in patients at highrisk of bleeding?. ### Response: Thepotential for bleeding.


Instruction: Patients who experience a bleed frequently have permanent or prolonged discontinuation of what?

Output: their anticoagulant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients who experience a bleed frequently have permanent or prolonged discontinuation of what?. ### Response: their anticoagulant.


Instruction: What is a safer anticoagulant than thrombin and factor Xa inhibitors?

Output: warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a safer anticoagulant than thrombin and factor Xa inhibitors?. ### Response: warfarin.


Instruction: What are the upstreamtargets for factor xI and factorxII in the contact pathway?

Output: factor XI and factor XII

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the upstreamtargets for factor xI and factorxII in the contact pathway?. ### Response: factor XI and factor XII.


Instruction: What is thrombosis with minimal or no role inhemostasis?

Output: factor XI and factor XII

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is thrombosis with minimal or no role inhemostasis?. ### Response: factor XI and factor XII.


Instruction: What are strategies to target factor XII or factorXI?

Output: antisense oligonucleotides that reduce hepaticsynthesis of the clotting proteins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are strategies to target factor XII or factorXI?. ### Response: antisense oligonucleotides that reduce hepaticsynthesis of the clotting proteins.


Instruction: Antisense oligonucleotides that reduce hepaticsynthesis of the clotting proteins are what?

Output: polyanion antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Antisense oligonucleotides that reduce hepaticsynthesis of the clotting proteins are what?. ### Response: polyanion antagonists.


Instruction: What are polyanion antagonists that attenuate contact activation by nullifying stimulators of the pathway?

Output: clotting proteins, monoclonal antibodiesthat block activation or activity, aptamers, small moleculesthat block the active site or induce allosteric modulation,and polyanion antagonists that attenuate contact activationby nullifying stimulators of the pathway.7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are polyanion antagonists that attenuate contact activation by nullifying stimulators of the pathway?. ### Response: clotting proteins, monoclonal antibodiesthat block activation or activity, aptamers, small moleculesthat block the active site or induce allosteric modulation,and polyanion antagonists that attenuate contact activationby nullifying stimulators of the pathway.7.


Instruction: What was compared with enoxaparin in 300 patientsundergoing elective knee arthroplasty?

Output: IONIS-416858

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was compared with enoxaparin in 300 patientsundergoing elective knee arthroplasty?. ### Response: IONIS-416858.


Instruction: How many days prior to surgery was enoxaparin given at adose of 40 mg?

Output: 35

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many days prior to surgery was enoxaparin given at adose of 40 mg?. ### Response: 35.


Instruction: How many mgIONIS-416858 regimen was noninferior?

Output: 200

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mgIONIS-416858 regimen was noninferior?. ### Response: 200.


Instruction: What regimen was superior in preventing the end point of asymptomatic DVT, pulmonary embolism, or VTE-related mortality?

Output: IONIS-416858

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What regimen was superior in preventing the end point of asymptomatic DVT, pulmonary embolism, or VTE-related mortality?. ### Response: IONIS-416858.


Instruction: What is another term for VTE-related mortality?

Output: pulmonary embolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for VTE-related mortality?. ### Response: pulmonary embolism.


Instruction: What was the rate of major or clinically relevant nonmajor bleeding in both IONIS-treated patients?

Output: 3%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the rate of major or clinically relevant nonmajor bleeding in both IONIS-treated patients?. ### Response: 3%.


Instruction: What does early rivaroxaban use after cardioembolic stroke not result in?

Output: hemorrhagic trans-formation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does early rivaroxaban use after cardioembolic stroke not result in?. ### Response: hemorrhagic trans-formation.


Instruction: What is the name of the prospective magnetic resonance imaging study that may not cause hemorrhagic transformation?

Output: Gioia LC, Kate M, Sivakumar L, Hussain D, Kalashyan H, Buck B, Bussiere M, Jeerakathil T, Shuaib A, Emery D, et al. Early rivaroxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective magnetic resonance imaging study that may not cause hemorrhagic transformation?. ### Response: Gioia LC, Kate M, Sivakumar L, Hussain D, Kalashyan H, Buck B, Bussiere M, Jeerakathil T, Shuaib A, Emery D, et al. Early rivaroxaban.


Instruction: What is the name of the study that investigated resonance imaging?

Output: STROKEAHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated resonance imaging?. ### Response: STROKEAHA.


Instruction: When was Stroke.47:1917-1919?

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Stroke.47:1917-1919?. ### Response: 2016.


Instruction: What is one of the main findings of the resonance imaging study?

Output: Early rivaroxaban use after cardioembolic stroke may not result in hemorrhagic trans-formation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the main findings of the resonance imaging study?. ### Response: Early rivaroxaban use after cardioembolic stroke may not result in hemorrhagic trans-formation.


Instruction: What is more effective than heparin?

Output: aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more effective than heparin?. ### Response: aspirin.


Instruction: What is the name of the meta-analysis of ischaemic stroke?

Output: individual patient data meta-analysis of randomised controlled trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis of ischaemic stroke?. ### Response: individual patient data meta-analysis of randomised controlled trials.


Instruction: What is more effective than aspirin in preventing early neurologic deteri-oration?

Output: Low-molecular-weight heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more effective than aspirin in preventing early neurologic deteri-oration?. ### Response: Low-molecular-weight heparin.


Instruction: What is the effect of low-molecular-weight heparin on neurologic outcome?

Output: improving six-month outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of low-molecular-weight heparin on neurologic outcome?. ### Response: improving six-month outcome.


Instruction: In what year did J Stroke Cerebrovasc Dis.23:1537–1544 appear?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did J Stroke Cerebrovasc Dis.23:1537–1544 appear?. ### Response: 2014.


Instruction: What is ALIAS?

Output: Albumin in Acute Ischemic Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ALIAS?. ### Response: Albumin in Acute Ischemic Stroke.


Instruction: What is the name of the double-blind, placebo-controlled trial of high-dose al-bumin?

Output: part 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the double-blind, placebo-controlled trial of high-dose al-bumin?. ### Response: part 2.


Instruction: What is the name of the double-blind, placebo-controlled trial?

Output: Counterpulsation to Upgrade Forward Flow in Stroke (CUFFS) Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the double-blind, placebo-controlled trial?. ### Response: Counterpulsation to Upgrade Forward Flow in Stroke (CUFFS) Trial.


Instruction: When did the Lancet Neurol. 2013 issue 12:1049-1058?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Lancet Neurol. 2013 issue 12:1049-1058?. ### Response: 2013.


Instruction: What are the parts 1 and 2 of ALIAS?

Output: NETT Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the parts 1 and 2 of ALIAS?. ### Response: NETT Investigators.


Instruction: What are the parts 1 and 2 of the Stroke trials?

Output: ALIAS Parts 1 and 2 and NETT Investigators. ALIAS (Albumin in Acute Ischemic Stroke) trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the parts 1 and 2 of the Stroke trials?. ### Response: ALIAS Parts 1 and 2 and NETT Investigators. ALIAS (Albumin in Acute Ischemic Stroke) trials.


Instruction: What is the name of the study that investigated the safety of using external counterpulsation to augment cardiac output?

Output: Counterpulsation to Upgrade Forward Flow in Stroke (CUFFS) Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the safety of using external counterpulsation to augment cardiac output?. ### Response: Counterpulsation to Upgrade Forward Flow in Stroke (CUFFS) Trial.


Instruction: What does CUFFS stand for?

Output: Counterpulsation to Upgrade Forward Flow in Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CUFFS stand for?. ### Response: Counterpulsation to Upgrade Forward Flow in Stroke.


Instruction: What is the name of the trial to augment cerebral blood flow in stroke?

Output: Neurological Emergencies Treatment Trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the trial to augment cerebral blood flow in stroke?. ### Response: Neurological Emergencies Treatment Trials.


Instruction: When was the Counterpulsation to Upgrade Forward Flow in Stroke Trial?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Counterpulsation to Upgrade Forward Flow in Stroke Trial?. ### Response: 2015.


Instruction: What is prehospital use of magnesium sulfate as neuroprotection in acute stroke?

Output: FAST-MAG Investigators and Coordinators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is prehospital use of magnesium sulfate as neuroprotection in acute stroke?. ### Response: FAST-MAG Investigators and Coordinators.


Instruction: What is the doi: 10.1056/NEJMoa1408827 236?

Output: N Engl J Med.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the doi: 10.1056/NEJMoa1408827 236?. ### Response: N Engl J Med..


Instruction: How does transcranial near-infrared laser therapy treat stroke patients?

Output: light approach

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does transcranial near-infrared laser therapy treat stroke patients?. ### Response: light approach.


Instruction: What is a translational science?

Output: transcranial near-infrared laser therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a translational science?. ### Response: transcranial near-infrared laser therapy.


Instruction: When was the last time a patient had a stroke?

Output: 1049–10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last time a patient had a stroke?. ### Response: 1049–10.


Instruction: What is the address of the International Society of Nephrology?

Output: Global Operations Center, Avenue des Arts1-2, B-1210 Brussels, Belgium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the address of the International Society of Nephrology?. ### Response: Global Operations Center, Avenue des Arts1-2, B-1210 Brussels, Belgium.


Instruction: Where is the Global Operations Center located?

Output: Brussels, Belgium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the Global Operations Center located?. ### Response: Brussels, Belgium.


Instruction: What should be addressed to: USA/Canada:Jane Liss, Tel: +1 732-890-9812, E-mail: jliss@triplethreatmedia.com and JenCallow, Tel?

Output: AdvertisingInquiries concerning display advertising

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be addressed to: USA/Canada:Jane Liss, Tel: +1 732-890-9812, E-mail: jliss@triplethreatmedia.com and JenCallow, Tel?. ### Response: AdvertisingInquiries concerning display advertising.


Instruction: Who is responsible for recruiting/classi fied advertising?

Output: Rob Issler

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is responsible for recruiting/classi fied advertising?. ### Response: Rob Issler.


Instruction: What is Rob Issler's email address?

Output: +1 321

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Rob Issler's email address?. ### Response: +1 321.


Instruction: Who should inquire about Kidney International Supplements?

Output: Craig Smith

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should inquire about Kidney International Supplements?. ### Response: Craig Smith.


Instruction: What does the International Society of Nephrology own?

Output: copyright

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the International Society of Nephrology own?. ### Response: copyright.


Instruction: What is the name of the organization that owns the journal?

Output: International Society of Nephrology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that owns the journal?. ### Response: International Society of Nephrology.


Instruction: Who is responsible for the use of the journal and contributions?

Output: International Society of Nephrology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is responsible for the use of the journal and contributions?. ### Response: International Society of Nephrology.


Instruction: What is not required for photocopying of articlespublished under the CC BY license?

Output: Permission

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not required for photocopying of articlespublished under the CC BY license?. ### Response: Permission.


Instruction: What may single photocopies of single articles be made for?

Output: personal use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may single photocopies of single articles be made for?. ### Response: personal use.


Instruction: What is required for all othercopying?

Output: Permission of the publisher and payment of a fee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is required for all othercopying?. ### Response: Permission of the publisher and payment of a fee.


Instruction: What is a noncommercial license?

Output: CC BY-NC-ND

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a noncommercial license?. ### Response: CC BY-NC-ND.


Instruction: What is the purpose of copying for?

Output: advertisingor promotional purposes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of copying for?. ### Response: advertisingor promotional purposes.


Instruction: What are special rates available for educational institutions that wish to make photocopies for classroom use?

Output: Special ratesare available for educational institutions that wish to make photocopies fornonpro ﬁ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are special rates available for educational institutions that wish to make photocopies for classroom use?. ### Response: Special ratesare available for educational institutions that wish to make photocopies fornonpro ﬁ.


Instruction: What is required for all articles published under a CC BY-NC-ND license?

Output: permission of the publisher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is required for all articles published under a CC BY-NC-ND license?. ### Response: permission of the publisher.


Instruction: What is not required for resale or distribution outside the subscribing institution or company?

Output: Permission

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not required for resale or distribution outside the subscribing institution or company?. ### Response: Permission.


Instruction: What type of license is required for all other derivative works?

Output: CC BY-NC-ND

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of license is required for all other derivative works?. ### Response: CC BY-NC-ND.


Instruction: What is required of all derivative works, includingcompilations and translations?

Output: permission of the publisher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is required of all derivative works, includingcompilations and translations?. ### Response: permission of the publisher.


Instruction: What does absence of RCT data preclude at this time?

Output: guideline recommenda-tions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does absence of RCT data preclude at this time?. ### Response: guideline recommenda-tions.


Instruction: When was this document downloaded?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this document downloaded?. ### Response: April 28, 2023.


Instruction: What is the effect of metformin on cardiovascu-lar disease among people with type 2 diabetes?

Output: a meta-analysis of randomised trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of metformin on cardiovascu-lar disease among people with type 2 diabetes?. ### Response: a meta-analysis of randomised trials.


Instruction: What are the results of empagliflozin and cardiovascular outcomes?

Output: mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of empagliflozin and cardiovascular outcomes?. ### Response: mortality.


Instruction: What type of diabetes is canagliflozin associated with?

Output: type 2 diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diabetes is canagliflozin associated with?. ### Response: type 2 diabetes.


Instruction: What year did N Engl J Med issue 377:644-57?

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did N Engl J Med issue 377:644-57?. ### Response: 2017.


Instruction: What is the name of the drug that has been linked to cardiovascular outcomes in type 2 diabetes?

Output: Liraglutide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug that has been linked to cardiovascular outcomes in type 2 diabetes?. ### Response: Liraglutide.


Instruction: What was the N Engl J Med. 2016:375:311–22?

Output: Liraglutide and cardiovascular outcomes in type 2 diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the N Engl J Med. 2016:375:311–22?. ### Response: Liraglutide and cardiovascular outcomes in type 2 diabetes.


Instruction: Who is the author of Dapagliflozin and cardiovascular outcomes?

Output: Wiviott

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of Dapagliflozin and cardiovascular outcomes?. ### Response: Wiviott.


Instruction: What is the name of the double-blind, randomised placebo-controlled trial?

Output: Lancet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the double-blind, randomised placebo-controlled trial?. ### Response: Lancet.


Instruction: What is another name for Harmony Outcomes?

Output: cardio-vascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for Harmony Outcomes?. ### Response: cardio-vascular disease.


Instruction: What is the name of the drug used to treat type 2 diabetes?

Output: Albiglutide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used to treat type 2 diabetes?. ### Response: Albiglutide.


Instruction: When was the N Engl J Med 375:1834-44 published?

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the N Engl J Med 375:1834-44 published?. ### Response: 2016.


Instruction: What year did the American Heart Association publish a report on heart disease and stroke statistics?

Output: 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did the American Heart Association publish a report on heart disease and stroke statistics?. ### Response: 2018.


Instruction: What type of diabetes is multifactorial intervention and car-diovascular disease in?

Output: type 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diabetes is multifactorial intervention and car-diovascular disease in?. ### Response: type 2.


Instruction: What year did N Engl J Med. 2003:348:383-93?

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did N Engl J Med. 2003:348:383-93?. ### Response: 2016.


Instruction: How did Gaede P, Vedel P, Larsen N, et al. study the effect of lifestyle on incident cardiovascular disease and mortality in patients with diabetes?

Output: Multifactorial intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Gaede P, Vedel P, Larsen N, et al. study the effect of lifestyle on incident cardiovascular disease and mortality in patients with diabetes?. ### Response: Multifactorial intervention.


Instruction: What is the effect of lifestyle on incident cardiovascular disease and mortality in patients with diabetes mellitus?

Output: Influence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of lifestyle on incident cardiovascular disease and mortality in patients with diabetes mellitus?. ### Response: Influence.


Instruction: What was the J Am Coll Cardiol. 2018:71:2867-76?

Output: Influence of lifestyle on incident cardiovascular disease and mortality in patients with diabetes mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the J Am Coll Cardiol. 2018:71:2867-76?. ### Response: Influence of lifestyle on incident cardiovascular disease and mortality in patients with diabetes mellitus.


Instruction: How did Rejeski WJ, Eh, Bertoni AG, et al. compare obese adults with type 2 diabetes?

Output: Lifestyle change and mobil-ity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Rejeski WJ, Eh, Bertoni AG, et al. compare obese adults with type 2 diabetes?. ### Response: Lifestyle change and mobil-ity.


Instruction: What is the name of the journal that studies the relationship between carbohydrate quality and mortality risk in diabetes mellitus sufferers?

Output: PLoS ONE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies the relationship between carbohydrate quality and mortality risk in diabetes mellitus sufferers?. ### Response: PLoS ONE.


Instruction: What does the journal PLoS ONE publish in 2012?

Output: 7:e43127

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the journal PLoS ONE publish in 2012?. ### Response: 7:e43127.


Instruction: How many cohorts of US men and women participated in a systematic review and meta-analysis of processed meat consumption and diabetes mellitus?

Output: three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many cohorts of US men and women participated in a systematic review and meta-analysis of processed meat consumption and diabetes mellitus?. ### Response: three.


Instruction: How many cohorts of US men and women have type 2 diabetes mellitus?

Output: three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many cohorts of US men and women have type 2 diabetes mellitus?. ### Response: three.


Instruction: What is the name of the meta-analysis of controlled clinical trials that examined exercise on glycemic control?

Output: Boulé NG, Haddad E, Kenny GP , et al. Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials. JAMA. 2001;286:1218–27. S4.2-23

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis of controlled clinical trials that examined exercise on glycemic control?. ### Response: Boulé NG, Haddad E, Kenny GP , et al. Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials. JAMA. 2001;286:1218–27. S4.2-23.


Instruction: What is the name of the group that studies the effects of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus?

Output: Diabetes Control and Complications Trial Research Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that studies the effects of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus?. ### Response: Diabetes Control and Complications Trial Research Group.


Instruction: When did N Engl J Med issue 329:977-86?

Output: 1993

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did N Engl J Med issue 329:977-86?. ### Response: 1993.


Instruction: What are the recommendations for the Treatment of Hyperlipidemia in Stage C HF?

Output: p atients With Cardiac Structural Abnormalities or remodeling With prior or Current Symptoms of HFrecommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the recommendations for the Treatment of Hyperlipidemia in Stage C HF?. ### Response: p atients With Cardiac Structural Abnormalities or remodeling With prior or Current Symptoms of HFrecommendations.


Instruction: What is reasonable to use as adjunctive therapy in patients with NYHA class II–IV symptoms?

Output: PUFA supplementation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable to use as adjunctive therapy in patients with NYHA class II–IV symptoms?. ### Response: PUFA supplementation.


Instruction: What is not beneficial as adjunctive therapy when prescribed solely for the diagnosis of HF in the absence of other indications?

Output: Statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not beneficial as adjunctive therapy when prescribed solely for the diagnosis of HF in the absence of other indications?. ### Response: Statins.


Instruction: In patients with NYHA class II–IV symptoms and HFrEF or HFpEF, unless contraindicated, to reduce mortality and what?

Output: cardiovascular hospitalizations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with NYHA class II–IV symptoms and HFrEF or HFpEF, unless contraindicated, to reduce mortality and what?. ### Response: cardiovascular hospitalizations.


Instruction: What is not indicated outside of current practice guidelines for the primary and secondary prevention of atherosclerotic vascular disease?

Output: routine use of statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not indicated outside of current practice guidelines for the primary and secondary prevention of atherosclerotic vascular disease?. ### Response: routine use of statins.


Instruction: What does HFpEF stand for?

Output: heart failure with preserved ejection fraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does HFpEF stand for?. ### Response: heart failure with preserved ejection fraction.


Instruction: What is HFrEF standing for? What does NYHA stand for in relation to heart failure?

Output: New York Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is HFrEF standing for? What does NYHA stand for in relation to heart failure?. ### Response: New York Heart Association.


Instruction: How many recommendations are there for the Treatment of Hyperlipidemia in Stages A and B HF?

Output: Table 10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many recommendations are there for the Treatment of Hyperlipidemia in Stages A and B HF?. ### Response: Table 10.


Instruction: What should be used to prevent cardiovascular events in patients with a recent or remote history of MI or ACS?

Output: statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be used to prevent cardiovascular events in patients with a recent or remote history of MI or ACS?. ### Response: statins.


Instruction: What is used to prevent cardiovascular events?

Output: statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used to prevent cardiovascular events?. ### Response: statins.


Instruction: What should be controlled in accordance with contemporary guidelines?

Output: Lipid disorders

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be controlled in accordance with contemporary guidelines?. ### Response: Lipid disorders.


Instruction: COR, Class of Recommendation; HF, heart failure; LOE, Level of Evidence; and MI, myocardial infarction.

Output: IIa B 8 5, 52, 272, 286ACS indicates acute coronary syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: COR, Class of Recommendation; HF, heart failure; LOE, Level of Evidence; and MI, myocardial infarction.. ### Response: IIa B 8 5, 52, 272, 286ACS indicates acute coronary syndrome.


Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020 Page 51 of 127 The Work Group systematically reviewed evidence related to what recommendation?

Output: Reviewed , New -added recommendatio n

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020 Page 51 of 127 The Work Group systematically reviewed evidence related to what recommendation?. ### Response: Reviewed , New -added recommendatio n.


Instruction: What did the Work Group's confidence in the quality of the evidence wa s very low?

Output: observational nature of data and outcomes assessment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Work Group's confidence in the quality of the evidence wa s very low?. ### Response: observational nature of data and outcomes assessment.


Instruction: What is limited by the observational nature of data and outcomes assessment?

Output: The evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is limited by the observational nature of data and outcomes assessment?. ### Response: The evidence.


Instruction: For almost all patients, there are what?

Output: no significant harms associated with the trial of a different statin or implementation of intermittent  dosing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For almost all patients, there are what?. ### Response: no significant harms associated with the trial of a different statin or implementation of intermittent  dosing.


Instruction: Data and outcomes assessment are what?

Output: observational nature

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Data and outcomes assessment are what?. ### Response: observational nature.


Instruction: For almost all patients, there are no significant harms associated with the trial of a different statin or implementation of intermittent dosing?

Output: there is a potential benefit of continuing treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For almost all patients, there are no significant harms associated with the trial of a different statin or implementation of intermittent dosing?. ### Response: there is a potential benefit of continuing treatment.


Instruction: What is there a potential benefit of continuing treatment?

Output: intermittent  dosing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is there a potential benefit of continuing treatment?. ### Response: intermittent  dosing.


Instruction: Because most agents in the class are available in generic formulations, it is unlikely that there will be a significant benefit to continuing treatment.

Output: switching statins will add a substantial financial burden

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Because most agents in the class are available in generic formulations, it is unlikely that there will be a significant benefit to continuing treatment.. ### Response: switching statins will add a substantial financial burden.


Instruction: What are statins available in?

Output: generic formulations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are statins available in?. ### Response: generic formulations.


Instruction: What is unlikely to add a substantial financial burden?

Output: switching statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is unlikely to add a substantial financial burden?. ### Response: switching statins.


Instruction: With proper education, most patients will be amenable to what?

Output: a change in statin or an intermittent dosing schedule

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: With proper education, most patients will be amenable to what?. ### Response: a change in statin or an intermittent dosing schedule.


Instruction: What has the most robust safety and clinical outcome databases of any treatment for dyslipidemia?

Output: statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has the most robust safety and clinical outcome databases of any treatment for dyslipidemia?. ### Response: statins.


Instruction: What did the Work Group determine was preferred over other, less robust interventions?

Output: any measures that continue statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Work Group determine was preferred over other, less robust interventions?. ### Response: any measures that continue statin therapy.


Instruction: What did the Work Group decide upon?

Output: a “Weak for” recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Work Group decide upon?. ### Response: a “Weak for” recommendation.


Instruction: What is needed to evaluate the relationship between vitamin D replacement or supplementation and statin induced myopathy?

Output: Randomized clinical trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed to evaluate the relationship between vitamin D replacement or supplementation and statin induced myopathy?. ### Response: Randomized clinical trials.


Instruction: What type of myopathy is needed?

Output: statin -induced

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of myopathy is needed?. ### Response: statin -induced.


Instruction: What kind of care is suggested to improve adherence to lipid lowering medications?

Output: intensified patient care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What kind of care is suggested to improve adherence to lipid lowering medications?. ### Response: intensified patient care.


Instruction: How many RCTs were reviewed in a systematic review?

Output: 35

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs were reviewed in a systematic review?. ### Response: 35.


Instruction: What did Van Driel and colleagues study?

Output: strategies to improve patient adherence to lipid -lowering medications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Van Driel and colleagues study?. ### Response: strategies to improve patient adherence to lipid -lowering medications.


Instruction: How did the systematic review find adherence to lipid-lowering medication improved?

Output: after intensified patient care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did the systematic review find adherence to lipid-lowering medication improved?. ### Response: after intensified patient care.


Instruction: What was improved after intensified patient care?

Output: adherence to lipid-lowering medication

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was improved after intensified patient care?. ### Response: adherence to lipid-lowering medication.


Instruction: What did the intensified care group have twice as likely to do?

Output: adherent to statin treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the intensified care group have twice as likely to do?. ### Response: adherent to statin treatment.


Instruction: When compared to standard care, what did these interventions demonstrate?

Output: significantly better adherence rates and a decrease in cholesterol levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When compared to standard care, what did these interventions demonstrate?. ### Response: significantly better adherence rates and a decrease in cholesterol levels.


Instruction: How much more likely were patients in the intensified care group to be adherent to statin treatment short term than those in the less intensive care group?

Output: twice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much more likely were patients in the intensified care group to be adherent to statin treatment short term than those in the less intensive care group?. ### Response: twice.


Instruction: How many times more likely to continue treatment long term?

Output: three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many times more likely to continue treatment long term?. ### Response: three.


Instruction: What type of care included drug regimen simplification, patient education and information, and intensified patient follow-up?

Output: Intensified

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of care included drug regimen simplification, patient education and information, and intensified patient follow-up?. ### Response: Intensified.


Instruction: What is one way to intensify patient follow up?

Output: phone calls

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one way to intensify patient follow up?. ### Response: phone calls.


Instruction: What is another way to increase patient follow -up?

Output: phone calls

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another way to increase patient follow -up?. ### Response: phone calls.


Instruction: What is the 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive SummaryCirculation. 2019;140:e563–e595. DOI: 10.1161/CIR.0000000000000677 September 10, 2019 e589CLINICAL STATEMENTS AND GUIDELINESPhysiopathologyNon-coronary revascularization?

Output: Arnett et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive SummaryCirculation. 2019;140:e563–e595. DOI: 10.1161/CIR.0000000000000677 September 10, 2019 e589CLINICAL STATEMENTS AND GUIDELINESPhysiopathologyNon-coronary revascularization?. ### Response: Arnett et al.


Instruction: What may have been used even when not explicitly specified?

Output: MeSH terms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may have been used even when not explicitly specified?. ### Response: MeSH terms.


Instruction: What is an example of a cardiac event?

Output: Myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a cardiac event?. ### Response: Myocardial infarction.


Instruction: Who is the Co-ChairUniversity of Kentucky College of Public Health?

Output: Donna K. Arnett

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Co-ChairUniversity of Kentucky College of Public Health?. ### Response: Donna K. Arnett.


Instruction: Who is a Professor of Epidemiology at the University of Kentucky?

Output: Donna K. Arnett

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a Professor of Epidemiology at the University of Kentucky?. ### Response: Donna K. Arnett.


Instruction: Who is the co-chair of the Ciccarone Center for the Prevention of Heart Disease?

Output: Roger S. Blumenthal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the co-chair of the Ciccarone Center for the Prevention of Heart Disease?. ### Response: Roger S. Blumenthal.


Instruction: What is the name of the professor of medicine at UCSF School of Medicine?

Output: Michelle A. Albert

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor of medicine at UCSF School of Medicine?. ### Response: Michelle A. Albert.


Instruction: Which University of Wisconsin School of Medicine and Public Health—Associate Professor of Medicine, Division of Cardiology?

Output: Zachary D. Goldberger

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which University of Wisconsin School of Medicine and Public Health—Associate Professor of Medicine, Division of Cardiology?. ### Response: Zachary D. Goldberger.


Instruction: What University of Kentucky College of Nursing—Professor?

Output: Ellen J. Hahn

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What University of Kentucky College of Nursing—Professor?. ### Response: Ellen J. Hahn.


Instruction: Who is the Professor of Nursing at the University of Kentucky?

Output: Marcia A. Dake

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Professor of Nursing at the University of Kentucky?. ### Response: Marcia A. Dake.


Instruction: What is the name of the Deputy Director of UK-CARES and Community Engagement Core?

Output: Ellen J. Hahn

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Deputy Director of UK-CARES and Community Engagement Core?. ### Response: Ellen J. Hahn.


Instruction: Who is the Dean of Research at Johns Hopkins?

Output: Associate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Dean of Research at Johns Hopkins?. ### Response: Associate.


Instruction: What is the name of the Deputy Director of the Institute for Clinical and Translational Research?

Output: Cheryl Dennison Himmelfarb

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Deputy Director of the Institute for Clinical and Translational Research?. ### Response: Cheryl Dennison Himmelfarb.


Instruction: When will the MeSH Terms Key Words be available?

Output: May 1, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When will the MeSH Terms Key Words be available?. ### Response: May 1, 2023.


Instruction: What is the 2013 ACCF/AHA STEMI Guideline e417592 focused update of?

Output: meta-analysis of cohort studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2013 ACCF/AHA STEMI Guideline e417592 focused update of?. ### Response: meta-analysis of cohort studies.


Instruction: What is a report of the American College of Cardiology Founda-tion/American Heart Association Task Force?

Output: Practice Guidelines and the Heart Rhythm Society

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a report of the American College of Cardiology Founda-tion/American Heart Association Task Force?. ### Response: Practice Guidelines and the Heart Rhythm Society.


Instruction: Who is a member of the Cardiology Founda-tion/American Heart Association Task Force on Practice Guidelines?

Output: O’Gara

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a member of the Cardiology Founda-tion/American Heart Association Task Force on Practice Guidelines?. ### Response: O’Gara.


Instruction: What year did Circulation. 2012:126:1784-1800?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Circulation. 2012:126:1784-1800?. ### Response: 2012.


Instruction: Which year did Erratum in: Circulations. 2013:e357–9.593?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which year did Erratum in: Circulations. 2013:e357–9.593?. ### Response: 2012.


Instruction: What year did Ann Intern Med publish 120:999–1006.594?

Output: 1994

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Ann Intern Med publish 120:999–1006.594?. ### Response: 1994.


Instruction: What is the name of the randomized controlled trial that evaluated the care transitions interven-tion?

Output: A reengineered hospital discharge program

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized controlled trial that evaluated the care transitions interven-tion?. ### Response: A reengineered hospital discharge program.


Instruction: What is a randomized controlled trial for postmyocardial infarc-tion patients?

Output: Evaluation of a community-based inner-city disease management program

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a randomized controlled trial for postmyocardial infarc-tion patients?. ### Response: Evaluation of a community-based inner-city disease management program.


Instruction: What is an improvement in 1-year car -diovascular clinical trial?

Output: discharge medication program

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an improvement in 1-year car -diovascular clinical trial?. ### Response: discharge medication program.


Instruction: What did Lappé DL, Franklin BA, Costa F, et al. do?

Output: Improvements in 1-year car -diovascular clinical outcomes associated with a hospital-based discharge medication program

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Lappé DL, Franklin BA, Costa F, et al. do?. ### Response: Improvements in 1-year car -diovascular clinical outcomes associated with a hospital-based discharge medication program.


Instruction: What was the name of the American Heart Association scientific statement from the Council on Clinical Excellence?

Output: American College of Cardiology Founda-tion/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the American Heart Association scientific statement from the Council on Clinical Excellence?. ### Response: American College of Cardiology Founda-tion/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society.


Instruction: What is the subcommittee on Exercise, Cardiac Rehabilitation, and Prevention?

Output: Council on Clinical Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the subcommittee on Exercise, Cardiac Rehabilitation, and Prevention?. ### Response: Council on Clinical Cardiology.


Instruction: What is a subcomitte on Physical Activity?

Output: Council on Nutrition, Physical Activity, and Metabolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a subcomitte on Physical Activity?. ### Response: Council on Nutrition, Physical Activity, and Metabolism.


Instruction: Who collaborates with the American Association of Cardiovascular and Pulmonary Rehabilitation?

Output: American Heart As-sociation scientific statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Cardiac Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcom-mittee on Physical Activity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who collaborates with the American Association of Cardiovascular and Pulmonary Rehabilitation?. ### Response: American Heart As-sociation scientific statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Cardiac Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcom-mittee on Physical Activity.


Instruction: What is Pulmonary Rehabilitation?

Output: American Asso-ciation of Cardiovascular

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Pulmonary Rehabilitation?. ### Response: American Asso-ciation of Cardiovascular.


Instruction: What is Erratum in: Circulation. 2005;111:1717.599?

Output: Su

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Erratum in: Circulation. 2005;111:1717.599?. ### Response: Su.


Instruction: Who is Suaya JA, Stason WB?

Output: Ades PA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Suaya JA, Stason WB?. ### Response: Ades PA.


Instruction: What is the name of the systematic review and meta-analysis of randomized controlled trials of patients with coronary heart disease?

Output: Exercise-based rehabilitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta-analysis of randomized controlled trials of patients with coronary heart disease?. ### Response: Exercise-based rehabilitation.


Instruction: When was the Am J Med 116:682-92.601?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Am J Med 116:682-92.601?. ### Response: 2004.


Instruction: What did cardiac rehabilitation have an impact on in the community?

Output: mortality and cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did cardiac rehabilitation have an impact on in the community?. ### Response: mortality and cardiovascular events.


Instruction: What does Circulation do?

Output: Impact of cardiac rehabilitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Circulation do?. ### Response: Impact of cardiac rehabilitation.


Instruction: What is the effect of smoking cessation on mor-tality after myocardial infarction: meta-analysis of cohort studies?

Output: Effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of smoking cessation on mor-tality after myocardial infarction: meta-analysis of cohort studies?. ### Response: Effect.


Instruction: What is a risk factor for smoking cessation after a myocardial infarction?

Output: mor -tality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for smoking cessation after a myocardial infarction?. ### Response: mor -tality.


Instruction: What are the nonmodifiable risk factors of age, sex, race/ethnicity, and genetic predisposition/family history not addressed in this report?

Output: Cardiovascular risk factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the nonmodifiable risk factors of age, sex, race/ethnicity, and genetic predisposition/family history not addressed in this report?. ### Response: Cardiovascular risk factors.


Instruction: What are some potentially modifiable risk factors?

Output: dyslipidemia, diabetes mellitus, smoking, obe-sity, PAD, and renal insufficiency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some potentially modifiable risk factors?. ### Response: dyslipidemia, diabetes mellitus, smoking, obe-sity, PAD, and renal insufficiency.


Instruction: What was the management of dyslipidemia the subject of?

Output: a recent ACC/AHA guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the management of dyslipidemia the subject of?. ### Response: a recent ACC/AHA guideline.


Instruction: The new guideline does not support continued use of what?

Output: specific low-density lipoprotein (LDL) cholesterol or non–high-density lipoprotein cholesterol treatment targets

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The new guideline does not support continued use of what?. ### Response: specific low-density lipoprotein (LDL) cholesterol or non–high-density lipoprotein cholesterol treatment targets.


Instruction: What is another name for low-density lipoprotein cholesterol?

Output: LDL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for low-density lipoprotein cholesterol?. ### Response: LDL.


Instruction: What does the guideline advocate the use of?

Output: a 10-year risk calculator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the guideline advocate the use of?. ### Response: a 10-year risk calculator.


Instruction: How long is the risk calculator to be used?

Output: 10-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the risk calculator to be used?. ### Response: 10-year.


Instruction: What does ACEI indicate?

Output: angiotensin-converting enzyme inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ACEI indicate?. ### Response: angiotensin-converting enzyme inhibitor.


Instruction: What does ARB mean?

Output: angiotensin receptor blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ARB mean?. ### Response: angiotensin receptor blocker.


Instruction: CCB means what?

Output: calcium channel blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: CCB means what?. ### Response: calcium channel blocker.


Instruction: What is CCB?

Output: calcium channel blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CCB?. ### Response: calcium channel blocker.


Instruction: What is DHP?

Output: dihydropyridine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is DHP?. ### Response: dihydropyridine.


Instruction: When is chlorthalidone preferred?

Output: if prior myocardial infarction, left ventricular systolic dysfunction, diabetes mellitus, or proteinuric chronic kidney disease is present

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is chlorthalidone preferred?. ### Response: if prior myocardial infarction, left ventricular systolic dysfunction, diabetes mellitus, or proteinuric chronic kidney disease is present.


Instruction: What type of diuretic should be used in the presence of HF?

Output: Loop diuretic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diuretic should be used in the presence of HF?. ### Response: Loop diuretic.


Instruction: What is the glomerular filtration rate?

Output: <30 mL·min−1·1.73 m−2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the glomerular filtration rate?. ### Response: <30 mL·min−1·1.73 m−2.


Instruction: What can be substituted if a -blocker is contraindicated?

Output: non-DHP CCB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be substituted if a -blocker is contraindicated?. ### Response: non-DHP CCB.


Instruction: What is a non-DHP CCB substituted for if left ventricular dysfunction or HF is present?

Output: β-blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a non-DHP CCB substituted for if left ventricular dysfunction or HF is present?. ### Response: β-blocker.


Instruction: HF, diabetes mellitus, or left ventricular dysfunction are symptoms of what?

Output: heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: HF, diabetes mellitus, or left ventricular dysfunction are symptoms of what?. ### Response: heart failure.


Instruction: What is the name of the drug that is used to treat HF?

Output: Loop diuretic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug that is used to treat HF?. ### Response: Loop diuretic.


Instruction: What is the acronym for abdominal aortic aneurysm?

Output: AAAIIb/BAAA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for abdominal aortic aneurysm?. ### Response: AAAIIb/BAAA.


Instruction: What does ACS stand for?

Output: acute coronary syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ACS stand for?. ### Response: acute coronary syndrome.


Instruction: Where can ahajournals.org be accessed?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can ahajournals.org be accessed?. ### Response: http://ahajournals.org.


Instruction: Why do blockers occur?

Output: rapid absorption or low bioavail-ability due to high first-pass metabolism by the cytochromeP450 (ie, CYP3A4 ) system

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why do blockers occur?. ### Response: rapid absorption or low bioavail-ability due to high first-pass metabolism by the cytochromeP450 (ie, CYP3A4 ) system.


Instruction: What is the cytochrome P450 system responsible for?

Output: high first-pass metabolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cytochrome P450 system responsible for?. ### Response: high first-pass metabolism.


Instruction: Do blockers result in high intraindividual and interindividual variability?

Output: These pharmacokinetic propertiesresult in high intraindividual and interindividual variability

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Do blockers result in high intraindividual and interindividual variability?. ### Response: These pharmacokinetic propertiesresult in high intraindividual and interindividual variability.


Instruction: What is cyclosporine?

Output: carbamaz-epine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is cyclosporine?. ### Response: carbamaz-epine.


Instruction: What is carbamaz-epine?

Output: cyclosporine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is carbamaz-epine?. ### Response: cyclosporine.


Instruction: How much increase in digoxin concentrations in first week of therapy?

Output: 50% to70%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much increase in digoxin concentrations in first week of therapy?. ### Response: 50% to70%.


Instruction: Why should verapamil and diltiazem be avoided?

Output: because of potentially pro-found adverse effects on AV nodal conduction, heart rate, orcardiac contractility

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why should verapamil and diltiazem be avoided?. ### Response: because of potentially pro-found adverse effects on AV nodal conduction, heart rate, orcardiac contractility.


Instruction: What is the most well tolerated calcium channel blocker?

Output: diltiazem

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most well tolerated calcium channel blocker?. ### Response: diltiazem.


Instruction: What are the major adverse effects of dihydropyridines related to?

Output: vasodilation and systemic hypotension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the major adverse effects of dihydropyridines related to?. ### Response: vasodilation and systemic hypotension.


Instruction: What can verapamil cause?

Output: constipation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can verapamil cause?. ### Response: constipation.


Instruction: What is effective in the treatment ofall forms of angina?

Output: Nitrates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is effective in the treatment ofall forms of angina?. ### Response: Nitrates.


Instruction: How do nitrates relax vascular smooth muscle in the systemic arteries?

Output: Nitrates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do nitrates relax vascular smooth muscle in the systemic arteries?. ### Response: Nitrates.


Instruction: What does short-term continuous nitroglycerin delivery protect the endothelium from?

Output: experimental ischemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does short-term continuous nitroglycerin delivery protect the endothelium from?. ### Response: experimental ischemia.


Instruction: What reduces ischemia during coronary angioplasty and physical exercise in IHD patients?

Output: Short-term continuous nitroglycerin delivery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What reduces ischemia during coronary angioplasty and physical exercise in IHD patients?. ### Response: Short-term continuous nitroglycerin delivery.


Instruction: What causes dilation of the artery wall not affected by plaque but independent of an intact endothelium?

Output: Nitroglycerin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes dilation of the artery wall not affected by plaque but independent of an intact endothelium?. ### Response: Nitroglycerin.


Instruction: Nitroglycerin contributes to coronary blood flowredistribution by augmenting collateral flow and lowering ventricular diastolic pressure?

Output: 866

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Nitroglycerin contributes to coronary blood flowredistribution by augmenting collateral flow and lowering ventricular diastolic pressure?. ### Response: 866.