Instruction: What is flowredistribution?

Output: coronary blood

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is flowredistribution?. ### Response: coronary blood.


Instruction: What is increased by augmenting collateral flow and lowering ventricular diastolic pressure?

Output: coronary blood flow

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is increased by augmenting collateral flow and lowering ventricular diastolic pressure?. ### Response: coronary blood flow.


Instruction: Preload is reduced, leading to what?

Output: reduc-tions in myocardial wall tension and myocardial oxygendemand

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Preload is reduced, leading to what?. ### Response: reduc-tions in myocardial wall tension and myocardial oxygendemand.


Instruction: What does nitroglycerin have antithrombotic and antiplatelet effects?

Output: 868,869

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does nitroglycerin have antithrombotic and antiplatelet effects?. ### Response: 868,869.


Instruction: What could offset the short-term ischemic preconditioning effects of nitrate therapy?

Output: Oxygen free radicalrelease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could offset the short-term ischemic preconditioning effects of nitrate therapy?. ### Response: Oxygen free radicalrelease.


Instruction: How is long-term nitrogen therapy associated with endothelialdysfunction?

Output: via accumulation of the same oxygen free radi-cals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is long-term nitrogen therapy associated with endothelialdysfunction?. ### Response: via accumulation of the same oxygen free radi-cals.


Instruction: The oxygen free radical accumulation increases what?

Output: arterial sensitivity to vasoconstrictors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The oxygen free radical accumulation increases what?. ### Response: arterial sensitivity to vasoconstrictors.


Instruction: What is beneficial in short-term administra-tion?

Output: oxygen free radi-cals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is beneficial in short-term administra-tion?. ### Response: oxygen free radi-cals.


Instruction: What increases arterial sensitivity to vasoconstrictors such as angiotensin II?

Output: oxygen free radical accumulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What increases arterial sensitivity to vasoconstrictors such as angiotensin II?. ### Response: oxygen free radical accumulation.


Instruction: What limitations limited the committee’s ability to establish the most app ropriate test thresholds?

Output: thresholds reported by the included studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What limitations limited the committee’s ability to establish the most app ropriate test thresholds?. ### Response: thresholds reported by the included studies.


Instruction: The committee decided to contact study authors seeking additional data at what threshold?

Output: particular thresholds

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committee decided to contact study authors seeking additional data at what threshold?. ### Response: particular thresholds.


Instruction: What did the committee limit this request to?

Output: data on NT -proBNP r ather than BNP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee limit this request to?. ### Response: data on NT -proBNP r ather than BNP.


Instruction: NT -proBNP has a greater sensitivity over a range of thresholds than what?

Output: BNP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: NT -proBNP has a greater sensitivity over a range of thresholds than what?. ### Response: BNP.


Instruction: What is the name of the book that treats heart failure?

Output: Chronic Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the book that treats heart failure?. ### Response: Chronic Heart Failure.


Instruction: What is CKD?

Output: Chronic kidney disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CKD?. ### Response: Chronic kidney disease.


Instruction: What is CKD defined by?

Output: a reduction in glomerular filtration  rate (eGFR) to <60 ml/min/1.73 m2 and/or persistent albuminuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CKD defined by?. ### Response: a reduction in glomerular filtration  rate (eGFR) to <60 ml/min/1.73 m2 and/or persistent albuminuria.


Instruction: What is chronic kidney disease defined by a reduction in eGFR to 60 ml/min/1.73 m2?

Output: at least stage 3A

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is chronic kidney disease defined by a reduction in eGFR to 60 ml/min/1.73 m2?. ### Response: at least stage 3A.


Instruction: Chronic kidney disease is a common and important comorbidity in peop le with heart failure that confers significant additional risks of mortality?

Output: Adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Chronic kidney disease is a common and important comorbidity in peop le with heart failure that confers significant additional risks of mortality?. ### Response: Adults.


Instruction: What is heart failure associated with?

Output: chronic kidney disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is heart failure associated with?. ### Response: chronic kidney disease.


Instruction: What is the eGFR3 0 ml/min/1.73 m2?

Output: severe CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the eGFR3 0 ml/min/1.73 m2?. ### Response: severe CKD.


Instruction: How have people with severe CKD been excluded from trials of heart failure pharmacotherapies?

Output: randomised controlled trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How have people with severe CKD been excluded from trials of heart failure pharmacotherapies?. ### Response: randomised controlled trials.


Instruction: What type of CKD can limit the ability to introduce and/or adequately up -titrate heart failure medications?

Output: HFREF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of CKD can limit the ability to introduce and/or adequately up -titrate heart failure medications?. ### Response: HFREF.


Instruction: What is eGFR 31 -59 ml/min/1.73 m2?

Output: The presence of even m ild or moderate CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is eGFR 31 -59 ml/min/1.73 m2?. ### Response: The presence of even m ild or moderate CKD.


Instruction: What are nephrotoxic medications often reduced or discontinued in people with worsening renal function?

Output: heart failure medications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are nephrotoxic medications often reduced or discontinued in people with worsening renal function?. ### Response: heart failure medications.


Instruction: People with CKD are more prone to develop adverse effects related to what?

Output: their heart failure medication

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: People with CKD are more prone to develop adverse effects related to what?. ### Response: their heart failure medication.


Instruction: Hyperkalaemia and hypotension are two of the adverse effects of heart failure medication.

Output: risks and cost effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hyperkalaemia and hypotension are two of the adverse effects of heart failure medication.. ### Response: risks and cost effectiveness.


Instruction: What is the term for a mild side effect that can be significant in the long term?

Output: worsening renal  function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for a mild side effect that can be significant in the long term?. ### Response: worsening renal  function.


Instruction: What are two other side effects that can occur with heart failure medications?

Output: hyperkalaemia and hypotension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are two other side effects that can occur with heart failure medications?. ### Response: hyperkalaemia and hypotension.


Instruction: What may be underutilized in people with heart failure who also have CKD?

Output: evidence -based pharmacotherapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be underutilized in people with heart failure who also have CKD?. ### Response: evidence -based pharmacotherapies.


Instruction: What is the most common type of HFREF?

Output: CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common type of HFREF?. ### Response: CKD.


Instruction: What is a potentially life-saving disease-modifying medication?

Output: albuminuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a potentially life-saving disease-modifying medication?. ### Response: albuminuria.


Instruction: What was highlighted as an important area to review when considering the update of this guideline?

Output: heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was highlighted as an important area to review when considering the update of this guideline?. ### Response: heart failure.


Instruction: What are the benefits, risks and cost effectiveness of pharmacological interventions for heart failure in people with heart failure who also have CKD?

Output: similar clinical

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the benefits, risks and cost effectiveness of pharmacological interventions for heart failure in people with heart failure who also have CKD?. ### Response: similar clinical.


Instruction: What is the PICO characteristic of review question Population Adults with heart failure and chronic kidney disease who are not on dialysis?

Output: at least stage 3A / eGFR <60 mL/min

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the PICO characteristic of review question Population Adults with heart failure and chronic kidney disease who are not on dialysis?. ### Response: at least stage 3A / eGFR <60 mL/min.


Instruction: eGFR 60 mL/min) who are not on dialysis?

Output: risks and cost effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: eGFR 60 mL/min) who are not on dialysis?. ### Response: risks and cost effectiveness.


Instruction: What is ACE?

Output: Angiotensin Converting Enzyme

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ACE?. ### Response: Angiotensin Converting Enzyme.


Instruction: Angiotensin Receptor Antagonist/ Blocker (ARB)?

Output: risks and cost effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Angiotensin Receptor Antagonist/ Blocker (ARB)?. ### Response: risks and cost effectiveness.


Instruction: What is the acronym for Receptor Antagonist?

Output: Mineralocorticoid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Receptor Antagonist?. ### Response: Mineralocorticoid.


Instruction: Digoxin and Diuretics are loop and loop related.

Output: risks and cost effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Digoxin and Diuretics are loop and loop related.. ### Response: risks and cost effectiveness.


Instruction: Ivabradine and Sacubitril -Valsartan are what?

Output: Hydralazine -Nitrate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Ivabradine and Sacubitril -Valsartan are what?. ### Response: Hydralazine -Nitrate.


Instruction: Hydralazine -Nitrate is what type of drug?

Output: Diuretics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hydralazine -Nitrate is what type of drug?. ### Response: Diuretics.


Instruction: What was the HR of patients in the lower 2 risk tertiles?

Output: 1.12

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the HR of patients in the lower 2 risk tertiles?. ### Response: 1.12.


Instruction: What did the results of the TIMACS trial suggest?

Output: superior outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the results of the TIMACS trial suggest?. ### Response: superior outcome.


Instruction: What was reduced by early rather than delayed inter-vention in the setting of UA/NSTEMI?

Output: refractory is-chemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was reduced by early rather than delayed inter-vention in the setting of UA/NSTEMI?. ### Response: refractory is-chemia.


Instruction: What were the risks of death, MI, and stroke among patients at the early approach?

Output: highest tertileof ischemic risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the risks of death, MI, and stroke among patients at the early approach?. ### Response: highest tertileof ischemic risk.


Instruction: What did the GRACE risk score define among patients at the highest tertileof ischemic risk?

Output: risksof death, MI, and stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the GRACE risk score define among patients at the highest tertileof ischemic risk?. ### Response: risksof death, MI, and stroke.


Instruction: What was used to assess if a more aggressive strategy of very earlyintervention would lead to better outcomes in patients with non-ST-elevation ACS?

Output: ABOARD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was used to assess if a more aggressive strategy of very earlyintervention would lead to better outcomes in patients with non-ST-elevation ACS?. ### Response: ABOARD.


Instruction: What did the ABOARD study compare angiography and intervention per-formed immediately on?

Output: presentation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the ABOARD study compare angiography and intervention per-formed immediately on?. ### Response: presentation.


Instruction: How many patients with unstable ischemic symptoms were randomized?

Output: 352

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with unstable ischemic symptoms were randomized?. ### Response: 352.


Instruction: How long after enrollment were patients randomized to immediate or delayed angiography and revascularization?

Output: 70 minutes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after enrollment were patients randomized to immediate or delayed angiography and revascularization?. ### Response: 70 minutes.


Instruction: What was the loading dose of clopi-dogrel?

Output: /H11350300 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the loading dose of clopi-dogrel?. ### Response: /H11350300 mg.


Instruction: How many hospitals had patients with unstable ischemic symptoms randomized?

Output: 13

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many hospitals had patients with unstable ischemic symptoms randomized?. ### Response: 13.


Instruction: What was the primary trial endpoint during thehospitalization period?

Output: peak troponin I value

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary trial endpoint during thehospitalization period?. ### Response: peak troponin I value.


Instruction: What did immediate intervention confer with regard to the primary endpoint?

Output: noadvantage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did immediate intervention confer with regard to the primary endpoint?. ### Response: noadvantage.


Instruction: In the immediate and delayed intervention groups, what was the mediantroponin I value?

Output: 2.1 versus 1.7 ng/mL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the immediate and delayed intervention groups, what was the mediantroponin I value?. ### Response: 2.1 versus 1.7 ng/mL.


Instruction: What was the mean ng/mL in the immediate and delayed intervention groups?

Output: 1.7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean ng/mL in the immediate and delayed intervention groups?. ### Response: 1.7.


Instruction: What was there a trend toward in the prespecifiedclinical secondary endpoint of death, MI, or urgent revascu-larization by 1 month?

Output: improved outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was there a trend toward in the prespecifiedclinical secondary endpoint of death, MI, or urgent revascu-larization by 1 month?. ### Response: improved outcome.


Instruction: How many trials did these 3 trials provide support for?

Output: 107,122,123

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many trials did these 3 trials provide support for?. ### Response: 107,122,123.


Instruction: What is the GRACE score for high risk patients?

Output: /H11022140

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the GRACE score for high risk patients?. ### Response: /H11022140.


Instruction: What is the GRACE score?

Output: /H11022140

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the GRACE score?. ### Response: /H11022140.


Instruction: What is reasonable in low- to intermediate-risk patients?

Output: a more delayed approach

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable in low- to intermediate-risk patients?. ### Response: a more delayed approach.


Instruction: When is the “early” time period?

Output: within the first 24 hours after hospital presentation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is the “early” time period?. ### Response: within the first 24 hours after hospital presentation.


Instruction: What is derived by angiography and intervention performed within the first fewhours of hospital admission?

Output: reduce ischemic complications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is derived by angiography and intervention performed within the first fewhours of hospital admission?. ### Response: reduce ischemic complications.


Instruction: What advantage of early intervention was achieved in the context of intensive background antithrom-botic therapy?

Output: noadvantage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What advantage of early intervention was achieved in the context of intensive background antithrom-botic therapy?. ### Response: noadvantage.


Instruction: What is the acronym for transcatheter aortic valve implantation?

Output: TAVI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for transcatheter aortic valve implantation?. ### Response: TAVI.


Instruction: How was the heterogeneity of the pooled results assessed?

Output: using the Higgins ’I2and the c2tests

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the heterogeneity of the pooled results assessed?. ### Response: using the Higgins ’I2and the c2tests.


Instruction: What was a Higgins 'I2value of $50% or c2P.05 considered to represent?

Output: signi ﬁcant heterogeneity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a Higgins 'I2value of $50% or c2P.05 considered to represent?. ### Response: signi ﬁcant heterogeneity.


Instruction: The overall certainty of the evidence was assessed for each important outcome of interest using what?

Output: GRADE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The overall certainty of the evidence was assessed for each important outcome of interest using what?. ### Response: GRADE.


Instruction: What is GRADE?

Output: Gradingof Recommendations, Assessment, Development, and Evaluation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is GRADE?. ### Response: Gradingof Recommendations, Assessment, Development, and Evaluation.


Instruction: How were evidence pro files created?

Output: using the GuidelineDevelopment Tool

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How were evidence pro files created?. ### Response: using the GuidelineDevelopment Tool.


Instruction: What did the GuidelineDevelopment Tool categorize?

Output: 1 of 4 levels: high, moderate, low, or very low

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the GuidelineDevelopment Tool categorize?. ### Response: 1 of 4 levels: high, moderate, low, or very low.


Instruction: How were recommendations graded according to CHEST's grading system?

Output: theGRADE approach

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How were recommendations graded according to CHEST's grading system?. ### Response: theGRADE approach.


Instruction: What did CHEST use to grade recommendations?

Output: GRADE approach

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did CHEST use to grade recommendations?. ### Response: GRADE approach.


Instruction: What do Strongrecommendations use the wording "we recommend"?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do Strongrecommendations use the wording "we recommend"?. ### Response: ”.


Instruction: What does "we suggest" do?

Output: account for patient values and preferences regarding these outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does "we suggest" do?. ### Response: account for patient values and preferences regarding these outcomes.


Instruction: The implications of the strength of recommendation are summarized in what?

Output: e-Table 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The implications of the strength of recommendation are summarized in what?. ### Response: e-Table 2.


Instruction: What was developed when a clinicallyrelevant area was felt to require a guiding comment?

Output: a weaksuggestion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was developed when a clinicallyrelevant area was felt to require a guiding comment?. ### Response: a weaksuggestion.


Instruction: What was replaced with a graded Consensus-BasedStatement?

Output: weaksuggestion was developed and “Ungraded Consensus-BasedStatement ”replaced the grade

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was replaced with a graded Consensus-BasedStatement?. ### Response: weaksuggestion was developed and “Ungraded Consensus-BasedStatement ”replaced the grade.


Instruction: Who were patient advocates?

Output: Mellanie True Hills and D. A. L.)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who were patient advocates?. ### Response: Mellanie True Hills and D. A. L.).


Instruction: Who participated in the panel discussion?

Output: 2 patient advocates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who participated in the panel discussion?. ### Response: 2 patient advocates.


Instruction: What did Hills and D. A. L. address?

Output: patient-centered issues

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Hills and D. A. L. address?. ### Response: patient-centered issues.


Instruction: How were the recommendations and suggestions presented to the panel?

Output: in an anonymous online voting survey

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How were the recommendations and suggestions presented to the panel?. ### Response: in an anonymous online voting survey.


Instruction: How many points is the Likert scale derived from?

Output: 5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many points is the Likert scale derived from?. ### Response: 5.


Instruction: Who recused himself from voting on recommendations?

Output: Panelists with COIs related to theindividual recommendations recused themselves from voting onthose statements. Of note, the chair (G. Y. H. L.)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who recused himself from voting on recommendations?. ### Response: Panelists with COIs related to theindividual recommendations recused themselves from voting onthose statements. Of note, the chair (G. Y. H. L.).


Instruction: What is the CHEST policy?

Output: each recommendation and statement required a 75% votingparticipation rate and at least 80%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the CHEST policy?. ### Response: each recommendation and statement required a 75% votingparticipation rate and at least 80%.


Instruction: How much voting did recommendations need to have to pass?

Output: 75%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much voting did recommendations need to have to pass?. ### Response: 75%.


Instruction: How much consensus was required to pass a recommendation?

Output: 80%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much consensus was required to pass a recommendation?. ### Response: 80%.


Instruction: What percentage of the vote did recommendations require?

Output: 75%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the vote did recommendations require?. ### Response: 75%.


Instruction: Who reviewed the methods used and the content of the manuscript for consistency, accuracy, and completeness?

Output: Peer Review ProcessReviewers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who reviewed the methods used and the content of the manuscript for consistency, accuracy, and completeness?. ### Response: Peer Review ProcessReviewers.


Instruction: How was the manuscript revised according to feedback from the reviewers?

Output: according to CHEST ’s grading system, which uses theGRADE approach

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the manuscript revised according to feedback from the reviewers?. ### Response: according to CHEST ’s grading system, which uses theGRADE approach.


Instruction: What is e- Appendix 1 of the Stroke Risk in AF?

Output: The extensive data on epidemiologic burden of strokeassociated with AF and well as the pathophysiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is e- Appendix 1 of the Stroke Risk in AF?. ### Response: The extensive data on epidemiologic burden of strokeassociated with AF and well as the pathophysiology.


Instruction: What is beyond the scope of this document to consider the epidemiology of all stroke?

Output: Stroke Risk in AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is beyond the scope of this document to consider the epidemiology of all stroke?. ### Response: Stroke Risk in AF.


Instruction: What could lead to some small cost savings?

Output: not substantially change current practice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could lead to some small cost savings?. ### Response: not substantially change current practice.


Instruction: People with advanced heart failure with other comorbid conditions may benefit from what?

Output: oxygen therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: People with advanced heart failure with other comorbid conditions may benefit from what?. ### Response: oxygen therapy.


Instruction: What is an example of a chronic lung disease?

Output: COPD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a chronic lung disease?. ### Response: COPD.


Instruction: What is a patient with pneum onia or pulmonary embolism able to benefit from oxygen therapy?

Output: palliative care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a patient with pneum onia or pulmonary embolism able to benefit from oxygen therapy?. ### Response: palliative care.


Instruction: What should be referred to the care of the dying adult guideline?

Output: people who are in the last weeks of life may find oxygen therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be referred to the care of the dying adult guideline?. ### Response: people who are in the last weeks of life may find oxygen therapy.


Instruction: What recently published British Thoracic Society Guideline for oxygen use in adults in healthcare and emergency settings?

Output: brit -thoracic.org.uk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What recently published British Thoracic Society Guideline for oxygen use in adults in healthcare and emergency settings?. ### Response: brit -thoracic.org.uk.


Instruction: What does the brit -thoracic.org.uk/document-library/clinical-information/oxygen/2017 -emergency -oxygen -guideli ne/bts -guideline -for-oxgen-use-in-adults-in healthcare and emergency-settings/ state that people should only be prescribed oxygen in palliative care when arterial oxygen saturation is?

Output: British Thoracic Society Guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the brit -thoracic.org.uk/document-library/clinical-information/oxygen/2017 -emergency -oxygen -guideli ne/bts -guideline -for-oxgen-use-in-adults-in healthcare and emergency-settings/ state that people should only be prescribed oxygen in palliative care when arterial oxygen saturation is?. ### Response: British Thoracic Society Guideline.


Instruction: What is the name of the vitamin K antagonist?

Output: vitamin K antagonist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the vitamin K antagonist?. ### Response: vitamin K antagonist.


Instruction: When was this publication released?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this publication released?. ### Response: April 28, 2023.


Instruction: How long is throombect omy in most neur oscience centr es?

Output: 2 4-hour

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is throombect omy in most neur oscience centr es?. ### Response: 2 4-hour.


Instruction: Stroke and transient ischaemic attack in o ver 16s: diagnosis and initial management(NG128)?

Output: NICE 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Stroke and transient ischaemic attack in o ver 16s: diagnosis and initial management(NG128)?. ### Response: NICE 2023.


Instruction: How manys: diagnosis and initial management(NG128)?

Output: 16

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How manys: diagnosis and initial management(NG128)?. ### Response: 16.


Instruction: When was the last updat ed?

Output: 13 April 2022

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last updat ed?. ### Response: 13 April 2022.


Instruction: What should a person take if they have a hear t rate less than 50 beats per minut e?

Output: beta-block ers, continue t he beta-block er treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should a person take if they have a hear t rate less than 50 beats per minut e?. ### Response: beta-block ers, continue t he beta-block er treatment.


Instruction: How many beats per minute?

Output: 50

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many beats per minute?. ### Response: 50.


Instruction: What is a trio ventricular block?

Output: atrio ventricular block

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a trio ventricular block?. ### Response: atrio ventricular block.


Instruction: When is beta-blocker treatment used?

Output: during hospital admission

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is beta-blocker treatment used?. ### Response: during hospital admission.


Instruction: What is a cause of failure?

Output: left v entricular syst olic dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a cause of failure?. ### Response: left v entricular syst olic dysfunction.


Instruction: How long after t he person's condition is stable?

Output: 48  hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after t he person's condition is stable?. ### Response: 48  hours.


Instruction: How long does it take for beta-blockers to be stable?

Output: 48  hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take for beta-blockers to be stable?. ### Response: 48  hours.


Instruction: What type of enzyme inhibit or block er if there are intolerable side effects?

Output: angiot ensin-con verting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of enzyme inhibit or block er if there are intolerable side effects?. ### Response: angiot ensin-con verting.


Instruction: What happens if the angiot ensin-converting enzyme inhibits or block t he enzyme?

Output: an aldost erone antagonist should still be off ered

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What happens if the angiot ensin-converting enzyme inhibits or block t he enzyme?. ### Response: an aldost erone antagonist should still be off ered.


Instruction: What happens to the left v entricular ejection fraction?

Output: failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What happens to the left v entricular ejection fraction?. ### Response: failure.


Instruction: What is not t olerat ed an aldost erone antagonist should still be offered?

Output: angiot ensin-con verting enzyme inhibit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not t olerat ed an aldost erone antagonist should still be offered?. ### Response: angiot ensin-con verting enzyme inhibit.


Instruction: What is Acut e hear t failure: diagnosis and management (CG187)?

Output: entricular ejection fraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Acut e hear t failure: diagnosis and management (CG187)?. ### Response: entricular ejection fraction.


Instruction: What is the subject t o Notice of right s?

Output: All right s reserved

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the subject t o Notice of right s?. ### Response: All right s reserved.


Instruction: When was the last updat ed?

Output: 17 No vember 2021

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last updat ed?. ### Response: 17 No vember 2021.


Instruction: What is needed to evaluate the impact of decision support tools?

Output: Additional studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed to evaluate the impact of decision support tools?. ### Response: Additional studies.


Instruction: What is needed to evaluate the impact of decision support tools on risk factor con-trol and secondary stroke prevention after stroke hospitalization?

Output: Additional studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed to evaluate the impact of decision support tools on risk factor con-trol and secondary stroke prevention after stroke hospitalization?. ### Response: Additional studies.


Instruction: The impact of telemedicine on acute stroke care is well established.

Output: 8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The impact of telemedicine on acute stroke care is well established.. ### Response: 8.


Instruction: What offers many potential benefits over in-person care?

Output: telemedicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What offers many potential benefits over in-person care?. ### Response: telemedicine.


Instruction: What may patients with stroke face multiple barriers to engaging in telemedicine?

Output: cognitive impairment and physical disability

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may patients with stroke face multiple barriers to engaging in telemedicine?. ### Response: cognitive impairment and physical disability.


Instruction: Research is needed to evaluate the impact of what?

Output: telemedicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Research is needed to evaluate the impact of what?. ### Response: telemedicine.


Instruction: What must be implemented across hospital and health systems in order to be effective?

Output: interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must be implemented across hospital and health systems in order to be effective?. ### Response: interventions.


Instruction: What must be implemented across hospital and health systems in order to achieve desired outcomes?

Output: interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must be implemented across hospital and health systems in order to achieve desired outcomes?. ### Response: interventions.


Instruction: What is needed to examine the implementation of interventions across health systems?

Output: Research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed to examine the implementation of interventions across health systems?. ### Response: Research.


Instruction: Interventions Aimed at Changing Patient BehaviorRecommendations for Behavior Change Interventions are summarized in what?

Output: online Data Supplements 63 and 64

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Interventions Aimed at Changing Patient BehaviorRecommendations for Behavior Change Interventions are summarized in what?. ### Response: online Data Supplements 63 and 64.


Instruction: What are the online Data Supplements 63 and 64 summarized in?

Output: COR LOE Recommendations1 B-R1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the online Data Supplements 63 and 64 summarized in?. ### Response: COR LOE Recommendations1 B-R1.


Instruction: In patients with ischemic stroke or TIA, behavior change interventions targeting stroke literacy, lifestyle factors, and medica-tion adherence are recommended to reduce cardiovascular events?

Output: information or advice alone, in the absence of a behavioral intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with ischemic stroke or TIA, behavior change interventions targeting stroke literacy, lifestyle factors, and medica-tion adherence are recommended to reduce cardiovascular events?. ### Response: information or advice alone, in the absence of a behavioral intervention.


Instruction: Teaching self-management skills or using behavior change theory can be helpful in improving what?

Output: medication adherence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Teaching self-management skills or using behavior change theory can be helpful in improving what?. ### Response: medication adherence.


Instruction: In patients with stroke or TIA, combined exercise-based and behavior change interventions are probably indicated in preference to behavior interventions alone, exercise interven-tions alone, and what else?

Output: usual care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with stroke or TIA, combined exercise-based and behavior change interventions are probably indicated in preference to behavior interventions alone, exercise interven-tions alone, and what else?. ### Response: usual care.


Instruction: What can be beneficial in patients with TIA or nondisabling stroke?

Output: engagement in targeted secondary prevention programs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be beneficial in patients with TIA or nondisabling stroke?. ### Response: engagement in targeted secondary prevention programs.


Instruction: What can be beneficial to reduce risk factors and recurrent ischemic events?

Output: engagement in targeted secondary prevention programs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be beneficial to reduce risk factors and recurrent ischemic events?. ### Response: engagement in targeted secondary prevention programs.


Instruction: What can engage in targeted secondary prevention programs for patients with disabling stroke?

Output: cardiac rehabilitation programs or exercise and lifestyle counseling programs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can engage in targeted secondary prevention programs for patients with disabling stroke?. ### Response: cardiac rehabilitation programs or exercise and lifestyle counseling programs.


Instruction: What can be beneficial to reduce vascular risk factors and mortality?

Output: targeted secondary prevention programs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be beneficial to reduce vascular risk factors and mortality?. ### Response: targeted secondary prevention programs.


Instruction: What is essential in patients with stroke or TIA?

Output: provision of health information or advice about stroke prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is essential in patients with stroke or TIA?. ### Response: provision of health information or advice about stroke prevention.


Instruction: What is essential about stroke prevention?

Output: provision of health information or advice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is essential about stroke prevention?. ### Response: provision of health information or advice.


Instruction: What is not an effective means to change modifiable, lifestyle-related risk factors in order to reduce stroke?

Output: information or advice alone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not an effective means to change modifiable, lifestyle-related risk factors in order to reduce stroke?. ### Response: information or advice alone.


Instruction: What is the focus of the 2015 ACC/AHA/SCAI Update?

Output: Primary PercutaneousCoronary Intervention for PatientsWith ST-Elevation Myocardial Infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the focus of the 2015 ACC/AHA/SCAI Update?. ### Response: Primary PercutaneousCoronary Intervention for PatientsWith ST-Elevation Myocardial Infarction.


Instruction: What was the 2013 guideline for the Management of ST-Elevation Myocardial Infarction?

Output: ACCF/AHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 2013 guideline for the Management of ST-Elevation Myocardial Infarction?. ### Response: ACCF/AHA.


Instruction: Who is the Chair of the Latin American Society of Interventional Cardiology?

Output: Glenn N. Levine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Chair of the Latin American Society of Interventional Cardiology?. ### Response: Glenn N. Levine.


Instruction: Who is the Vice Chair of the WritingCommittee?

Output: Deborah D. Ascheim

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Vice Chair of the WritingCommittee?. ### Response: Deborah D. Ascheim.


Instruction: What is the name of the MD, FACC, FAHA, FSCAI, Vice Chair?

Output: Frederick G. Kushner

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the MD, FACC, FAHA, FSCAI, Vice Chair?. ### Response: Frederick G. Kushner.


Instruction: Who is the MD, FACC, FSCAI?

Output: Jacqueline E. Tamis-Holland

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the MD, FACC, FSCAI?. ### Response: Jacqueline E. Tamis-Holland.


Instruction: What is the name of the MD who is the FAHA?

Output: Joseph Woo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the MD who is the FAHA?. ### Response: Joseph Woo.


Instruction: Who is required to recuse themselves from voting on sections to which their specific relationships with industry mayapply?

Output: Writing committee members

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is required to recuse themselves from voting on sections to which their specific relationships with industry mayapply?. ### Response: Writing committee members.


Instruction: Who is a representative of the ACC/AHA Task Force on ClinicalPractice Guidelines Liaison?

Output: zSCAI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a representative of the ACC/AHA Task Force on ClinicalPractice Guidelines Liaison?. ### Response: zSCAI.


Instruction: Who is the Vice Chair of the Stemi WritingCommittee?

Output: Deborah D. Ascheim

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Vice Chair of the Stemi WritingCommittee?. ### Response: Deborah D. Ascheim.


Instruction: Who is the MD, MPH, MACC, FSCAI, FAHA?

Output: Ralph G. Brindis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the MD, MPH, MACC, FSCAI, FAHA?. ### Response: Ralph G. Brindis.


Instruction: What is the name of the doctor who is a doctor of medicine?

Output: Umesh N. Khot

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the doctor who is a doctor of medicine?. ### Response: Umesh N. Khot.


Instruction: Who is a member of the FAHA?

Output: Joseph Woo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a member of the FAHA?. ### Response: Joseph Woo.


Instruction: What is the name of the doctor?

Output: Umesh N. Khot

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the doctor?. ### Response: Umesh N. Khot.


Instruction: Who is the MD?

Output: Umesh N. Khot

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the MD?. ### Response: Umesh N. Khot.


Instruction: Where is Kristin Newby?

Output: MD, MHS, FACC, FAHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Kristin Newby?. ### Response: MD, MHS, FACC, FAHA.


Instruction: What is the name of the doctor who accepted the award?

Output: Barry A. Franklin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the doctor who accepted the award?. ### Response: Barry A. Franklin.


Instruction: Who accepted the Award?

Output: Latin American Society of Interventional CardiologyPCI WritingCommittee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who accepted the Award?. ### Response: Latin American Society of Interventional CardiologyPCI WritingCommittee.


Instruction: What is one of the reasons why Deborah D. Ascheim accepted it?

Output: writing effort was completed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the reasons why Deborah D. Ascheim accepted it?. ### Response: writing effort was completed.


Instruction: Who accepted a position at Capricor Therapeutics in August 2015?

Output: Dr. Deborah D. Ascheim

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who accepted a position at Capricor Therapeutics in August 2015?. ### Response: Dr. Deborah D. Ascheim.


Instruction: In accordance with ACC/AHA policy, who recused herself from the final voting process?

Output: Writing committee members

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In accordance with ACC/AHA policy, who recused herself from the final voting process?. ### Response: Writing committee members.


Instruction: What year was the AMERICAN HEART ASSOCIATION, INC. founded?

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the AMERICAN HEART ASSOCIATION, INC. founded?. ### Response: 2016.


Instruction: What is the ISBN number of the Society forCARDIOVASCULAR ANGIOGRAPHY AND INTERVENTIONS?

Output: 0735-1097

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ISBN number of the Society forCARDIOVASCULAR ANGIOGRAPHY AND INTERVENTIONS?. ### Response: 0735-1097.


Instruction: What are interventions primarily aimed at moderating BP?

Output: advice on lifestyle and administration ofpharmacological agents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are interventions primarily aimed at moderating BP?. ### Response: advice on lifestyle and administration ofpharmacological agents.


Instruction: What have the efficacies of bothstrategies been widely studied in the general population?

Output: high BP .

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have the efficacies of bothstrategies been widely studied in the general population?. ### Response: high BP ..


Instruction: What system did most RCTs involve?

Output: renin-angiotensin-aldosterone system

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What system did most RCTs involve?. ### Response: renin-angiotensin-aldosterone system.


Instruction: Why are these agents over-represented in the 2004 KDOQI guideline?

Output: availability of the evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why are these agents over-represented in the 2004 KDOQI guideline?. ### Response: availability of the evidence.


Instruction: What is RAAS?

Output: renin-angiotensin-aldosterone system

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is RAAS?. ### Response: renin-angiotensin-aldosterone system.


Instruction: What is the focus of the Guideline?

Output: management and the comparativeeffectiveness of various interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the focus of the Guideline?. ### Response: management and the comparativeeffectiveness of various interventions.


Instruction: What is often elevated in CKD populations?

Output: BP levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is often elevated in CKD populations?. ### Response: BP levels.


Instruction: What is the preferred and most robust evidence derived from large-scale RCTs?

Output: assessed hard clinical outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the preferred and most robust evidence derived from large-scale RCTs?. ### Response: assessed hard clinical outcomes.


Instruction: How many patients were in each arm of the ERT?

Output: 50

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were in each arm of the ERT?. ### Response: 50.


Instruction: What are some of the outcomes of interest in BP control?

Output: mortality, cardiovascular events and changesin kidney function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the outcomes of interest in BP control?. ### Response: mortality, cardiovascular events and changesin kidney function.


Instruction: What can reduce BP by using agents that interfere with RAAS?

Output: acute reductions inkidney function and albuminuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can reduce BP by using agents that interfere with RAAS?. ### Response: acute reductions inkidney function and albuminuria.


Instruction: What was the minimum duration of follow-up in RCTs required for inclusion in the evidence review?

Output: 1 year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the minimum duration of follow-up in RCTs required for inclusion in the evidence review?. ### Response: 1 year.


Instruction: How long was the minimal duration for kidney function, cardi-ovascular outcomes, and mortality set at?

Output: 1 year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the minimal duration for kidney function, cardi-ovascular outcomes, and mortality set at?. ### Response: 1 year.


Instruction: Why were there so few trials assessing lifestyle?

Output: Because there were so few trialsassessing lifestyle modiﬁcations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why were there so few trials assessing lifestyle?. ### Response: Because there were so few trialsassessing lifestyle modiﬁcations.


Instruction: How long was the minimum follow-up period for BP reduction?

Output: 6 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the minimum follow-up period for BP reduction?. ### Response: 6 weeks.


Instruction: Who conducted a systematic review of RCTs involving individuals with CKD?

Output: The ERT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who conducted a systematic review of RCTs involving individuals with CKD?. ### Response: The ERT.


Instruction: Who supplemented the systematic review with published systematic reviews and meta-analyses?

Output: Work Group members

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who supplemented the systematic review with published systematic reviews and meta-analyses?. ### Response: Work Group members.


Instruction: Who helped identify RCTs thatincluded CKD subgroups?

Output: Work Group members

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who helped identify RCTs thatincluded CKD subgroups?. ### Response: Work Group members.


Instruction: What did the Work Group make reference to when referring to large popula-tion studies?

Output: observational evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Work Group make reference to when referring to large popula-tion studies?. ### Response: observational evidence.


Instruction: The Work Group made reference to observational evidence from large what?

Output: popula-tion studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The Work Group made reference to observational evidence from large what?. ### Response: popula-tion studies.


Instruction: What have all questions of interest been the subject of?

Output: mortality, cardiovascular events and changesin kidney function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have all questions of interest been the subject of?. ### Response: mortality, cardiovascular events and changesin kidney function.


Instruction: What do some issues do not lend themselves to studying in thismanner?

Output: Not all questions of interest have been the subject of RCTs;some issues do not lend themselves to be studied in thismanner. T o facilitate further discussion on major issuesrelevant to management of BP in CKD patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do some issues do not lend themselves to studying in thismanner?. ### Response: Not all questions of interest have been the subject of RCTs;some issues do not lend themselves to be studied in thismanner. T o facilitate further discussion on major issuesrelevant to management of BP in CKD patients.


Instruction: What did theWork Group include in its chapter on Future Directions?

Output: major issuesrelevant to management of BP in CKD patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did theWork Group include in its chapter on Future Directions?. ### Response: major issuesrelevant to management of BP in CKD patients.


Instruction: What can exacerbate ischemia in patients treated with nitrates?

Output: profound hypotension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can exacerbate ischemia in patients treated with nitrates?. ### Response: profound hypotension.


Instruction: What type of patients are at increased risk of hypertension?

Output: the elderly

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of patients are at increased risk of hypertension?. ### Response: the elderly.


Instruction: What is a problem even within the first 24 hours?

Output: Nitrate tolerance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a problem even within the first 24 hours?. ### Response: Nitrate tolerance.


Instruction: What should be implemented to minimize nitrate tolerance?

Output: reducing intravenous doses and implementing intermittent dosing by nonintravenous routes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be implemented to minimize nitrate tolerance?. ### Response: reducing intravenous doses and implementing intermittent dosing by nonintravenous routes.


Instruction: What is a cornerstone of ACS treatment?

Output: β-Blockersβ-Blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a cornerstone of ACS treatment?. ### Response: β-Blockersβ-Blockers.


Instruction: What are -Blockers able to reduce?

Output: heart rate and BP and thus myo-cardial oxygen demand

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are -Blockers able to reduce?. ### Response: heart rate and BP and thus myo-cardial oxygen demand.


Instruction: What was one of the first therapies shown to reduce infarct size?

Output: β-Blockersβ-Blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was one of the first therapies shown to reduce infarct size?. ### Response: β-Blockersβ-Blockers.


Instruction: What reduces early sudden death after MI via antiarrhythmic effects and by preventing myocardial rupture?

Output: β-Blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What reduces early sudden death after MI via antiarrhythmic effects and by preventing myocardial rupture?. ### Response: β-Blockers.


Instruction: In patients with STEMI, the long-term benefits of -blocker administration have been shown in what?

Output: multiple trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with STEMI, the long-term benefits of -blocker administration have been shown in what?. ### Response: multiple trials.


Instruction: What has been shown in multiple trials?

Output: Early intravenous β-blockade

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been shown in multiple trials?. ### Response: Early intravenous β-blockade.


Instruction: Routine discharge use of -blockers is now a qual-ity performance measure for patients with what?

Output: hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Routine discharge use of -blockers is now a qual-ity performance measure for patients with what?. ### Response: hypertension.


Instruction: What should be initiated early and contin-ued for at least 3 years after ACS?

Output: β-blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be initiated early and contin-ued for at least 3 years after ACS?. ### Response: β-blockers.


Instruction: What did early intravenous -blockade reduce in a number of trials performed in the fibrinolytic era?

Output: mortality or recurrent MI192

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did early intravenous -blockade reduce in a number of trials performed in the fibrinolytic era?. ### Response: mortality or recurrent MI192.


Instruction: What was used as routine therapy in ACS for many years?

Output: Early intravenous β-blockade

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was used as routine therapy in ACS for many years?. ### Response: Early intravenous β-blockade.


Instruction: What trial has led to a revision of the recommendations for intra-venous -blocker use?

Output: arction Trial (COMMIT)/Chinese Cardiac Study (CCC) 2 trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What trial has led to a revision of the recommendations for intra-venous -blocker use?. ### Response: arction Trial (COMMIT)/Chinese Cardiac Study (CCC) 2 trial.


Instruction: How many AMI patients were randomized to the CCC 2 trial?

Output: 45 852

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many AMI patients were randomized to the CCC 2 trial?. ### Response: 45 852.


Instruction: How many AMI patients were randomized to -blockers?

Output: 45 852

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many AMI patients were randomized to -blockers?. ### Response: 45 852.


Instruction: What were the coprimary outcomes of the study?

Output: death, reinfarction, or cardiac arrest and death resulting from any cause

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the coprimary outcomes of the study?. ### Response: death, reinfarction, or cardiac arrest and death resulting from any cause.


Instruction: How long did it take for the outcome to be reduced with metoprolol?

Output: 4 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for the outcome to be reduced with metoprolol?. ### Response: 4 weeks.


Instruction: What did the COMMIT trial show about rein-farction and ventricular fibrillation?

Output: a reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the COMMIT trial show about rein-farction and ventricular fibrillation?. ### Response: a reduction.


Instruction: What was the increase in cardiogenic shock with intravenous -blocker use?

Output: 5.0% versus 3.9%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the increase in cardiogenic shock with intravenous -blocker use?. ### Response: 5.0% versus 3.9%).


Instruction: What percentage of patients had intravenous -blocker use?

Output: 45 852

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients had intravenous -blocker use?. ### Response: 45 852.


Instruction: What was the highest risk of shock in the first 2 days of hospitalization?

Output: excess

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the highest risk of shock in the first 2 days of hospitalization?. ### Response: excess.


Instruction: Patients with evidence of hemo-dynamic instability or borderline hemodynamics at presenta-tion had what risk?

Output: excess risk of shock

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with evidence of hemo-dynamic instability or borderline hemodynamics at presenta-tion had what risk?. ### Response: excess risk of shock.


Instruction: What was the SBP >140 mm Hg?

Output: hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the SBP >140 mm Hg?. ### Response: hypertension.


Instruction: What was there no statistically significant differ?

Output: hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was there no statistically significant differ?. ### Response: hypertension.


Instruction: Baddour et al Infective Endocarditis in Adults What is the name of the clinical profile of infection in adults?

Output: 1481lead endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Baddour et al Infective Endocarditis in Adults What is the name of the clinical profile of infection in adults?. ### Response: 1481lead endocarditis.


Instruction: Heart. 2005;91:e10. doi: 10.1136/hrt.2004.040659 What is Staphylococcus lugdunensis?

Output: infective endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Heart. 2005;91:e10. doi: 10.1136/hrt.2004.040659 What is Staphylococcus lugdunensis?. ### Response: infective endocarditis.


Instruction: What is a literature review and analysis of risk factors for endocarditis?

Output: Staphylococcus lugdunensis infective endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a literature review and analysis of risk factors for endocarditis?. ### Response: Staphylococcus lugdunensis infective endocarditis.


Instruction: What is the hidden peril of coagulase-negative staphylococcus in blood cul-tures?

Output: Staphylococcus lugdunensis endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the hidden peril of coagulase-negative staphylococcus in blood cul-tures?. ### Response: Staphylococcus lugdunensis endocarditis.


Instruction: What is the name of the gene used in the detection of Staphylococcus lugdunensis?

Output: fbl

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the gene used in the detection of Staphylococcus lugdunensis?. ### Response: fbl.


Instruction: What does the fbl gene do?

Output: Detection of Staphylococcus lugdunensis by a new species-specific PCR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the fbl gene do?. ### Response: Detection of Staphylococcus lugdunensis by a new species-specific PCR.


Instruction: Where can you find a copy of the FEMS Immunol Med Microbiol 201058?

Output: 1128/JCM.00342-09

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find a copy of the FEMS Immunol Med Microbiol 201058?. ### Response: 1128/JCM.00342-09.


Instruction: What is the difference between real-time PCR and conventional biochemical methods for identification of Staphylococcus lugdunensis?

Output: Comparison

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between real-time PCR and conventional biochemical methods for identification of Staphylococcus lugdunensis?. ### Response: Comparison.


Instruction: What is a short-course therapy for right-side endocarditis due to?

Output: Staphylococcus aureus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a short-course therapy for right-side endocarditis due to?. ### Response: Staphylococcus aureus.


Instruction: What is short-course therapy for for right-side endocarditis due to Staphylococcus aureus in drug abusers?

Output: cloxacillin versus glyco-peptides in combination with gentamicin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is short-course therapy for for right-side endocarditis due to Staphylococcus aureus in drug abusers?. ### Response: cloxacillin versus glyco-peptides in combination with gentamicin.


Instruction: What does cloxacillin versus glyco-peptides in combination with gentamicin do?

Output: Short-course therapy for right-side endocarditis due to Staphylococcus aureus in drug abusers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does cloxacillin versus glyco-peptides in combination with gentamicin do?. ### Response: Short-course therapy for right-side endocarditis due to Staphylococcus aureus in drug abusers.


Instruction: When did Clin Infect Dis. 2001;33:120–125.

Output: 2001

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Clin Infect Dis. 2001;33:120–125.. ### Response: 2001.


Instruction: What is the initial low-dose gentamicin for?

Output: Staphylococcus aureus bacteremia and endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the initial low-dose gentamicin for?. ### Response: Staphylococcus aureus bacteremia and endocarditis.


Instruction: What is nephrotoxic for Staphylococcus aureus bacteremia and endocarditis?

Output: Initial low-dose gentamicin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is nephrotoxic for Staphylococcus aureus bacteremia and endocarditis?. ### Response: Initial low-dose gentamicin.


Instruction: What type of antibiotic is used to treat right-sided staphylococcal endocarditis in injection drug users?

Output: cloxacillin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of antibiotic is used to treat right-sided staphylococcal endocarditis in injection drug users?. ### Response: cloxacillin.


Instruction: What is the difference between oral antibiotic treatment and parenteral therapy?

Output: nephrotoxic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between oral antibiotic treatment and parenteral therapy?. ### Response: nephrotoxic.


Instruction: What is the treatment of right-sided Staphylococcus aureus endocarditis in intravenous drug users with cipro-floxacin and rifampicin?

Output: Short-course therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the treatment of right-sided Staphylococcus aureus endocarditis in intravenous drug users with cipro-floxacin and rifampicin?. ### Response: Short-course therapy.


Instruction: What does Murray HW, Wigley FM, Mann JJ, Arthur RR use?

Output: methicillin sodium-gentamicin sulfate therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Murray HW, Wigley FM, Mann JJ, Arthur RR use?. ### Response: methicillin sodium-gentamicin sulfate therapy.


Instruction: What is the name of the study that investigated the treatment of Staphylococcus aureus endocarditis in nonaddicts and those addicted to paren-teral drugs?

Output: a prospective study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the treatment of Staphylococcus aureus endocarditis in nonaddicts and those addicted to paren-teral drugs?. ### Response: a prospective study.


Instruction: What is a combination of vancomycin and a -lactam used for?

Output: staphylococcal bacteremia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a combination of vancomycin and a -lactam used for?. ### Response: staphylococcal bacteremia.


Instruction: In what year was the Ann Intern Med 97:496–503?

Output: 1982

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was the Ann Intern Med 97:496–503?. ### Response: 1982.


Instruction: What is the effect of vancomycin and -lactam on staphylococcal bacteremia?

Output: empirical combina-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of vancomycin and -lactam on staphylococcal bacteremia?. ### Response: empirical combina-tion.


Instruction: What year did Clin Infect Dis publish a 57:1760–1765.

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Clin Infect Dis publish a 57:1760–1765.. ### Response: 2013.


Instruction: What is a reasonable interruption of statin treatment?

Output: 2 – 4 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a reasonable interruption of statin treatment?. ### Response: 2 – 4 weeks.


Instruction: What can be repeated with the same statin if symptoms were deemed non- statin related?

Output: Statin treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be repeated with the same statin if symptoms were deemed non- statin related?. ### Response: Statin treatment.


Instruction: What is an acceptable option in patients with continued tolerance issues?

Output: intermittent dosing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an acceptable option in patients with continued tolerance issues?. ### Response: intermittent dosing.


Instruction: What should be discontinued in the rare case of a serious adverse event?

Output: statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be discontinued in the rare case of a serious adverse event?. ### Response: statins.


Instruction: What is a serious adverse event that should be stopped with statins?

Output: rhabdomyolysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a serious adverse event that should be stopped with statins?. ### Response: rhabdomyolysis.


Instruction: What vitamin deficiency is involved in statin induced myopathy?

Output: vitamin D

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What vitamin deficiency is involved in statin induced myopathy?. ### Response: vitamin D.


Instruction: Why was the quality of the two available cohort studies low?

Output: a small number of patients and different protocols for vitamin D supplementation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the quality of the two available cohort studies low?. ### Response: a small number of patients and different protocols for vitamin D supplementation.


Instruction: Why was the Work Group unable to make a recommendation on vitamin D supplementation?

Output: The conf idence in the quality of the two available cohort studies was very low based on a small number of patients and different protocols for vitamin D supplementation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the Work Group unable to make a recommendation on vitamin D supplementation?. ### Response: The conf idence in the quality of the two available cohort studies was very low based on a small number of patients and different protocols for vitamin D supplementation.


Instruction: How many grafts were there?

Output: 1315

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many grafts were there?. ### Response: 1315.


Instruction: What was the occlusion rate in all of the aspirin groups combined with the placebo group?

Output: 15.8%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the occlusion rate in all of the aspirin groups combined with the placebo group?. ### Response: 15.8%.


Instruction: How much did early postoperative aspirine improve for 60-day and 1-year grafting patency?

Output: 59.7%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much did early postoperative aspirine improve for 60-day and 1-year grafting patency?. ### Response: 59.7%..


Instruction: How long after CABG did Mangano et al. evaluate the impact of aspirin administration?

Output: 48 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after CABG did Mangano et al. evaluate the impact of aspirin administration?. ### Response: 48 hours.


Instruction: How many patients survived the first 48 hours after surgery?

Output: 5022

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients survived the first 48 hours after surgery?. ### Response: 5022.


Instruction: How much aspirin was administered to 59.7% of patients?

Output: 650 mg daily

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much aspirin was administered to 59.7% of patients?. ### Response: 650 mg daily.


Instruction: What was associated with a 68% reduction in the incidence of post-operative death?

Output: postoperative aspirin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with a 68% reduction in the incidence of post-operative death?. ### Response: postoperative aspirin therapy.


Instruction: Aspirin was associated with a 48% reduction in the incidence of what type of death?

Output: MI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Aspirin was associated with a 48% reduction in the incidence of what type of death?. ### Response: MI.


Instruction: What was the reduction in post-operative death associated with aspirin?

Output: 68%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the reduction in post-operative death associated with aspirin?. ### Response: 68%.


Instruction: How much reduction was there in the number of strokes?

Output: 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much reduction was there in the number of strokes?. ### Response: 50%.


Instruction: What was the reduction in the incidence of renal failure?

Output: 74%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the reduction in the incidence of renal failure?. ### Response: 74%.


Instruction: What is the reduction of bowel infarction?

Output: 62%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the reduction of bowel infarction?. ### Response: 62%.


Instruction: How long after surgery was aspirin administered?

Output: 4-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after surgery was aspirin administered?. ### Response: 4-year.


Instruction: How many hours of surgery was safe?

Output: 48

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many hours of surgery was safe?. ### Response: 48.


Instruction: What was the odds ratio for adverse events for CABG patients?

Output: 0.63

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the odds ratio for adverse events for CABG patients?. ### Response: 0.63.


Instruction: How was the 95% con-fidence interval?

Output: 0.54–0.74

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the 95% con-fidence interval?. ### Response: 0.54–0.74.


Instruction: What did Johnson et al19 find about CABG patients who took aspi-rin over a 4-year period after surgery?

Output: significantly better long-term survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Johnson et al19 find about CABG patients who took aspi-rin over a 4-year period after surgery?. ### Response: significantly better long-term survival.


Instruction: What was the relative risk of death of patients who did not take aspirin?

Output: 0.58

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the relative risk of death of patients who did not take aspirin?. ### Response: 0.58.


Instruction: What was the strongest predictor of death at 4 years in the SYNTAX trial?

Output: a lack of aspirin prescription

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the strongest predictor of death at 4 years in the SYNTAX trial?. ### Response: a lack of aspirin prescription.


Instruction: How long was the analysis of the CABG cohort?

Output: long-term

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the analysis of the CABG cohort?. ### Response: long-term.


Instruction: What is the acronym for Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery?

Output: SYNTAX

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery?. ### Response: SYNTAX.


Instruction: What is the strongest predictor of death at 4 years?

Output: lack of aspirin prescription

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the strongest predictor of death at 4 years?. ### Response: lack of aspirin prescription.


Instruction: What was the hazard ratio?

Output: 3.56

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the hazard ratio?. ### Response: 3.56.


Instruction: How many randomized trials were reviewed in a meta-analysis?

Output: 17

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many randomized trials were reviewed in a meta-analysis?. ### Response: 17.


Instruction: How many randomized trials were included in the meta-analysis?

Output: 17

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many randomized trials were included in the meta-analysis?. ### Response: 17.


Instruction: What did aspirin reduce the odds of graft occlusion compared with placebo?

Output: 22.6%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did aspirin reduce the odds of graft occlusion compared with placebo?. ### Response: 22.6%.


Instruction: Aspirin plus dipyridamole versus aspirin alone: OR, 0.94; 95% CI, 0.72–1.24; P=0.71?

Output: Combining dipyri-damole with aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Aspirin plus dipyridamole versus aspirin alone: OR, 0.94; 95% CI, 0.72–1.24; P=0.71?. ### Response: Combining dipyri-damole with aspirin.


Instruction: What is most concerning in the setting of uncontrolled hypertension?

Output: the risk of hemor -rhagic stroke is increased

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is most concerning in the setting of uncontrolled hypertension?. ### Response: the risk of hemor -rhagic stroke is increased.


Instruction: What is another reason for the aggressive control of hypertension in patients with ACS?

Output: hemor -rhagic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another reason for the aggressive control of hypertension in patients with ACS?. ### Response: hemor -rhagic stroke.


Instruction: What is challenging in ACS patients with severe hypertension?

Output: Rapidly stabilizing patients to facilitate prompt coronary reperfusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is challenging in ACS patients with severe hypertension?. ### Response: Rapidly stabilizing patients to facilitate prompt coronary reperfusion.


Instruction: What is inherent to the use of medications largely limiting or disrupting intraluminal thrombus formation?

Output: the potential for severe secondary bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is inherent to the use of medications largely limiting or disrupting intraluminal thrombus formation?. ### Response: the potential for severe secondary bleeding.


Instruction: The decision to pursue an inva-sive as opposed to a conservative approach should be based on what?

Output: standard clinical, demographic, and angiographic criteria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The decision to pursue an inva-sive as opposed to a conservative approach should be based on what?. ### Response: standard clinical, demographic, and angiographic criteria.


Instruction: What should be based on standard clinical, demographic, and angiographic criteria?

Output: The decision to pursue an inva-sive

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be based on standard clinical, demographic, and angiographic criteria?. ### Response: The decision to pursue an inva-sive.


Instruction: What should not influence revascu-larization decisions other than indirectly in relation to factors such as renal function?

Output: hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not influence revascu-larization decisions other than indirectly in relation to factors such as renal function?. ### Response: hypertension.


Instruction: With uncontrolled hypertension bleeding risks are notably higher?

Output: 5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: With uncontrolled hypertension bleeding risks are notably higher?. ### Response: 5.


Instruction: What are notably higher with uncontrolled hypertension?

Output: bleeding risks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are notably higher with uncontrolled hypertension?. ### Response: bleeding risks.


Instruction: What will continue to be highly prevalent among patients with ACS?

Output: Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will continue to be highly prevalent among patients with ACS?. ### Response: Hypertension.