Instruction: ARB may be considered in persistent symptomatic patients withHFrEF on what?

Output: GDMTIIb

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ARB may be considered in persistent symptomatic patients withHFrEF on what?. ### Response: GDMTIIb.


Instruction: How many beta blockers are recommended for patients withHFrEF?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many beta blockers are recommended for patients withHFrEF?. ### Response: 3.


Instruction: What is recommended in patients with NYHA class?

Output: Aldosterone receptor antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended in patients with NYHA class?. ### Response: Aldosterone receptor antagonists.


Instruction: What type of aldosterone receptor antagonists are recommended in patients with NYHA class II-IV?

Output: Aldosterone receptor antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of aldosterone receptor antagonists are recommended in patients with NYHA class II-IV?. ### Response: Aldosterone receptor antagonists.


Instruction: What is the LVEF /C2035%IA of patients with acute MI with symptoms of HF or DMIB?

Output: 181,182,197

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the LVEF /C2035%IA of patients with acute MI with symptoms of HF or DMIB?. ### Response: 181,182,197.


Instruction: Inappropriate use of what may be harmful?

Output: aldosterone receptor antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Inappropriate use of what may be harmful?. ### Response: aldosterone receptor antagonists.


Instruction: What can be harmful III: Harm B 198,199Hydralazine and isosorbide dinitrate is recommended for AfricanAmericans with NYHA class III–IV HF rEF on GDMTIA 179,180A combination of what can be useful in patients withHFrEF who cannot be given ACE inhibitors or ARBsIIa B?

Output: Inappropriate use of aldosterone receptor antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be harmful III: Harm B 198,199Hydralazine and isosorbide dinitrate is recommended for AfricanAmericans with NYHA class III–IV HF rEF on GDMTIA 179,180A combination of what can be useful in patients withHFrEF who cannot be given ACE inhibitors or ARBsIIa B?. ### Response: Inappropriate use of aldosterone receptor antagonists.


Instruction: What can be beneficial in patients with HF rEF IIa B 202–209AnticoagulationPatients with chronic HF with permanent/persistent/paroxysmal AF and an additionalrisk factor for cardioembolic stroke should receive chronic anticoagulant therapy?

Output: DigoxinDigoxin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be beneficial in patients with HF rEF IIa B 202–209AnticoagulationPatients with chronic HF with permanent/persistent/paroxysmal AF and an additionalrisk factor for cardioembolic stroke should receive chronic anticoagulant therapy?. ### Response: DigoxinDigoxin.


Instruction: What is not recommended in patients with chronic HF rEF without AF?

Output: agulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended in patients with chronic HF rEF without AF?. ### Response: agulation.


Instruction: What should be individualized?

Output: anticoagulant agent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be individualized?. ### Response: anticoagulant agent.


Instruction: What are statins not beneficial as when prescribed solely for HF?

Output: adjunctive therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are statins not beneficial as when prescribed solely for HF?. ### Response: adjunctive therapy.


Instruction: What is reasonable to use as adjunctive therapy in HF rEFor HF PEF?

Output: ARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable to use as adjunctive therapy in HF rEFor HF PEF?. ### Response: ARBs.


Instruction: What is not recommended in HF rEF III: No Benefit B 231,232Hormonal therapies other than to correct deficiencies are not recommended?

Output: Nutritional supplements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended in HF rEF III: No Benefit B 231,232Hormonal therapies other than to correct deficiencies are not recommended?. ### Response: Nutritional supplements.


Instruction: What are drugs known to adversely affect?

Output: aldosterone receptor antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are drugs known to adversely affect?. ### Response: aldosterone receptor antagonists.


Instruction: What are drugs known to adversely affect the clinical status of patients with HF rEF that should be avoided or withdrawn?

Output: Beneﬁt C N/ADrugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are drugs known to adversely affect the clinical status of patients with HF rEF that should be avoided or withdrawn?. ### Response: Beneﬁt C N/ADrugs.


Instruction: What is not recommended long-term use of an infusion of a positive inotropic drug?

Output: palliation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended long-term use of an infusion of a positive inotropic drug?. ### Response: palliation.


Instruction: What is not recommended except as palliation?

Output: Long-term use of an infusion of a positive inotropic drug

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended except as palliation?. ### Response: Long-term use of an infusion of a positive inotropic drug.


Instruction: Harm C N/A

Output: III

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Harm C N/A. ### Response: III.


Instruction: What is the name of the organization that represents the American Heart Association Stroke Council?

Output: Council on Cardiovascular and Stroke Nursing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that represents the American Heart Association Stroke Council?. ### Response: Council on Cardiovascular and Stroke Nursing.


Instruction: What are the names of the organizations that represent the American heart association?

Output: Stroke Council; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; and Council on Quality of Care and Outcomes Research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the organizations that represent the American heart association?. ### Response: Stroke Council; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; and Council on Quality of Care and Outcomes Research.


Instruction: Who is a member of the Council on Clinical Cardiology?

Output: Yaghi S, Willey JZ, Cucchiara B, Goldstein JN, Gonzales NR, Khatri P, Kim LJ, Mayer SA, Sheth KN, Schwamm LH; on behalf of the American Heart Association Stroke Council

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a member of the Council on Clinical Cardiology?. ### Response: Yaghi S, Willey JZ, Cucchiara B, Goldstein JN, Gonzales NR, Khatri P, Kim LJ, Mayer SA, Sheth KN, Schwamm LH; on behalf of the American Heart Association Stroke Council.


Instruction: What is a sci-entific statement for healthcare professionals from the American Heart Association/American Stroke Association?

Output: Treatment and outcome of hemorrhagic transformation after intravenous alteplase in acute ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a sci-entific statement for healthcare professionals from the American Heart Association/American Stroke Association?. ### Response: Treatment and outcome of hemorrhagic transformation after intravenous alteplase in acute ischemic stroke.


Instruction: What is an example of hemorrhagic transformation after intravenous alteplase in acute ischemic stroke?

Output: Treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of hemorrhagic transformation after intravenous alteplase in acute ischemic stroke?. ### Response: Treatment.


Instruction: What is the 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, and management of high blood pressure in adults?

Output: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, and management of high blood pressure in adults?. ### Response: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.


Instruction: What did the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines do?

Output: prevention, detection, eval-uation, and management of high blood pressure in adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines do?. ### Response: prevention, detection, eval-uation, and management of high blood pressure in adults.


Instruction: When was the corrected version of the report published?

Output: 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the corrected version of the report published?. ### Response: 2018.


Instruction: What is the name of the task force on clinical practice guidelines?

Output: American College of Cardiology/American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the task force on clinical practice guidelines?. ### Response: American College of Cardiology/American Heart Association.


Instruction: What is the name of the group that causes infective endocarditis?

Output: viridans group streptococci

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that causes infective endocarditis?. ### Response: viridans group streptococci.


Instruction: What year did the American Heart Association publish its endocarditis prevention guidelines?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did the American Heart Association publish its endocarditis prevention guidelines?. ### Response: 2007.


Instruction: How many successive population-based surveys did Duval X, Delahaye F, Alla F, et al. conduct infective endocardi-tis in the context of prophylaxis guideline modifications?

Output: three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many successive population-based surveys did Duval X, Delahaye F, Alla F, et al. conduct infective endocardi-tis in the context of prophylaxis guideline modifications?. ### Response: three.


Instruction: How many successive population-based surveys have been conducted?

Output: three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many successive population-based surveys have been conducted?. ### Response: three.


Instruction: What did the 2007 American Heart Association antibiotic prophylaxis guidelines have an impact on?

Output: Trends in endocarditis hospitaliza-tions at US children’s hospitals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the 2007 American Heart Association antibiotic prophylaxis guidelines have an impact on?. ### Response: Trends in endocarditis hospitaliza-tions at US children’s hospitals.


Instruction: What is the name of the NICE guideline?

Output: cessation of antibiotic prophylaxis for prevention of infective endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the NICE guideline?. ### Response: cessation of antibiotic prophylaxis for prevention of infective endocarditis.


Instruction: When did the trends in infective endocarditis in-cidence, microbiology, and valve replacement in the US begin?

Output: 2000 to 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the trends in infective endocarditis in-cidence, microbiology, and valve replacement in the US begin?. ### Response: 2000 to 2011.


Instruction: What was the J Am Coll Cardiol 2015;65:2070–6?

Output: Trends in infective endocarditis in-cidence, microbiology, and valve replacement in the United States from 2000 to 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the J Am Coll Cardiol 2015;65:2070–6?. ### Response: Trends in infective endocarditis in-cidence, microbiology, and valve replacement in the United States from 2000 to 2011.


Instruction: What is the impact of the NICE guideline rec-ommending cessation of antibiotic prophylaxis for prevention of infective endocarditis?

Output: before and after study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact of the NICE guideline rec-ommending cessation of antibiotic prophylaxis for prevention of infective endocarditis?. ### Response: before and after study.


Instruction: What was the BMJ's 2011 issue 342:d2392?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the BMJ's 2011 issue 342:d2392?. ### Response: 2011.


Instruction: How was the Circulation. 2000 issue 102:2842–8?

Output: Risk factors for infective endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the Circulation. 2000 issue 102:2842–8?. ### Response: Risk factors for infective endocarditis.


Instruction: What is the name of the large multicenter registry of infective endocarditis after transcatheter aortic valve implantation?

Output: Circulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the large multicenter registry of infective endocarditis after transcatheter aortic valve implantation?. ### Response: Circulation.


Instruction: What are the names of the authors of the study?

Output: Desimone DC, Tleyjeh IM, Correa de Sa DD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the authors of the study?. ### Response: Desimone DC, Tleyjeh IM, Correa de Sa DD.


Instruction: What type of endocarditis does a patient develop after a transfemoral trans-catheter aortic valve replacement?

Output: infective

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of endocarditis does a patient develop after a transfemoral trans-catheter aortic valve replacement?. ### Response: infective.


Instruction: What is the J Am Coll Cardiol 2016 67:2907–8?

Output: Incidence, predictors, and outcome of patients developing infective endocarditis following transfemoral trans-catheter aortic valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the J Am Coll Cardiol 2016 67:2907–8?. ### Response: Incidence, predictors, and outcome of patients developing infective endocarditis following transfemoral trans-catheter aortic valve replacement.


Instruction: When was the J Heart Valve Dis. 2002 11:660–4?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Heart Valve Dis. 2002 11:660–4?. ### Response: 2002.


Instruction: What is endocarditis after mitral valve repair?

Output: Risk factors and management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is endocarditis after mitral valve repair?. ### Response: Risk factors and management.


Instruction: What is Botoman VA, Surawicz CM. Bacteremia with gastrointestinal endoscopic procedures?

Output: 27

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Botoman VA, Surawicz CM. Bacteremia with gastrointestinal endoscopic procedures?. ### Response: 27.


Instruction: Gastrointest Endosc. 1986;32:342–6.

Output: Bacteremia with gastrointestinal endoscopic procedures. Gastrointest Endosc. 1986;32:342–6. 28. Low DE, Shoenut JP , Kennedy JK, et al. Risk of bacteremia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Gastrointest Endosc. 1986;32:342–6.. ### Response: Bacteremia with gastrointestinal endoscopic procedures. Gastrointest Endosc. 1986;32:342–6. 28. Low DE, Shoenut JP , Kennedy JK, et al. Risk of bacteremia.


Instruction: What is the risk of bacteremia with endoscopic sphincterotomy?

Output: 28. Low DE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of bacteremia with endoscopic sphincterotomy?. ### Response: 28. Low DE.


Instruction: What is a prospective assessment of risk with colonoscopy and polypectomy?

Output: bacteremia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a prospective assessment of risk with colonoscopy and polypectomy?. ### Response: bacteremia.


Instruction: What is the best practice policy statement on urologic surgery antimicrobial prophylaxis?

Output: NICE guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the best practice policy statement on urologic surgery antimicrobial prophylaxis?. ### Response: NICE guideline.


Instruction: What is anticoagulation for in patients with VHD?

Output: prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is anticoagulation for in patients with VHD?. ### Response: prevention.


Instruction: 1.5.1 Refer people at an y stage if tr eatment fails to contr ol the sympt oms of atrial fibrillation and mor e specialised management is needed?

Output: 1.5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: 1.5.1 Refer people at an y stage if tr eatment fails to contr ol the sympt oms of atrial fibrillation and mor e specialised management is needed?. ### Response: 1.5.


Instruction: How long should you wait for atrial fibrillation to recur?

Output: 4  weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long should you wait for atrial fibrillation to recur?. ### Response: 4  weeks.


Instruction: What should you do aft er the failed tr eatment?

Output: Refer people pr ompt ly at an y stage if tr eatment f ails t o contr ol the sympt oms of atrial fibrillation and mor e specialised management is needed. This should be wit hin 4  weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should you do aft er the failed tr eatment?. ### Response: Refer people pr ompt ly at an y stage if tr eatment f ails t o contr ol the sympt oms of atrial fibrillation and mor e specialised management is needed. This should be wit hin 4  weeks.


Instruction: How long is needed?

Output: 4  weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is needed?. ### Response: 4  weeks.


Instruction: When discussing benefits and risks of anticoagulation use what?

Output: clinical risk profiles and personal pr eferences t o guide tr eatment choices

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When discussing benefits and risks of anticoagulation use what?. ### Response: clinical risk profiles and personal pr eferences t o guide tr eatment choices.


Instruction: What do you use to guide tr eatment choices?

Output: clinical risk profiles and personal pr eferences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do you use to guide tr eatment choices?. ### Response: clinical risk profiles and personal pr eferences.


Instruction: What do most people outweigh t he bleeding risk?

Output: benefit of anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do most people outweigh t he bleeding risk?. ### Response: benefit of anticoagulation.


Instruction: What may not alwa ys outweigh t he bleeding risk?

Output: benefit of anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may not alwa ys outweigh t he bleeding risk?. ### Response: benefit of anticoagulation.


Instruction: What is impor tant of?

Output: bleeding risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is impor tant of?. ### Response: bleeding risk.


Instruction: When deciding betw een anticoagulation tr eatment options?

Output: Apixaban, dabigatran, edo xaban and rivaroxaban ar e all r ecommended as options, when used in line wit h the criteria specified in t he relevant NICE t echnology appraisal guidance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When deciding betw een anticoagulation tr eatment options?. ### Response: Apixaban, dabigatran, edo xaban and rivaroxaban ar e all r ecommended as options, when used in line wit h the criteria specified in t he relevant NICE t echnology appraisal guidance.


Instruction: What is NICE's guideline on medicines adherence and patient decision aids?

Output: medicines optimisation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE's guideline on medicines adherence and patient decision aids?. ### Response: medicines optimisation.


Instruction: What is NICE's guideline on medicines optimisation?

Output: patient decision aids

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE's guideline on medicines optimisation?. ### Response: patient decision aids.


Instruction: What is the British National F ormular y?

Output: guidance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the British National F ormular y?. ### Response: guidance.


Instruction: What does MHRA advise on in people with renal impairment?

Output: dosages

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does MHRA advise on in people with renal impairment?. ### Response: dosages.


Instruction: What is a dir ect-acting oral anticoagulant for people with atrial fibrillation?

Output: Offer anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a dir ect-acting oral anticoagulant for people with atrial fibrillation?. ### Response: Offer anticoagulation.


Instruction: What is an oral anticoagulant for people with atrial fibrillation?

Output: CHA 2DS2-VASc scor e of 2 or abo ve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an oral anticoagulant for people with atrial fibrillation?. ### Response: CHA 2DS2-VASc scor e of 2 or abo ve.


Instruction: What is a CHA 2DS2-VASc scor e of 2 or above?

Output: abo ve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a CHA 2DS2-VASc scor e of 2 or above?. ### Response: abo ve.


Instruction: Apixaban, dabigatran, edo xaban and rivaroxaban ar e all r ecommended as options when used in line with what criteria?

Output: NICE t echnology appraisal guidance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Apixaban, dabigatran, edo xaban and rivaroxaban ar e all r ecommended as options when used in line with what criteria?. ### Response: NICE t echnology appraisal guidance.


Instruction: Atrial fibrillation: diagnosis and management (NG196) NICE 2022.

Output: Apixaban, dabigatran, edo xaban and rivaroxaban ar e all r ecommended as options, when used in line wit h the criteria specified in t he relevant NICE t echnology appraisal guidance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atrial fibrillation: diagnosis and management (NG196) NICE 2022.. ### Response: Apixaban, dabigatran, edo xaban and rivaroxaban ar e all r ecommended as options, when used in line wit h the criteria specified in t he relevant NICE t echnology appraisal guidance.


Instruction: What is the name of the NICE t echnology appraisal guidance?

Output: Atrial fibrillation: diagnosis and management (NG196)© NICE 2022

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the NICE t echnology appraisal guidance?. ### Response: Atrial fibrillation: diagnosis and management (NG196)© NICE 2022.


Instruction: What is the last updat ed 30 June 2021?

Output: Page 11of 47

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the last updat ed 30 June 2021?. ### Response: Page 11of 47.


Instruction: What was the rate of systemic embolism and stroke with warfarin?

Output: 1.5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the rate of systemic embolism and stroke with warfarin?. ### Response: 1.5%.


Instruction: How much was edoxaban's risk of stroke?

Output: 1.2%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much was edoxaban's risk of stroke?. ### Response: 1.2%.


Instruction: When was the focus on atrial fibrillation published?

Output: July 9, 2019

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the focus on atrial fibrillation published?. ### Response: July 9, 2019.


Instruction: What was the rate of major bleeding with warfarin?

Output: 3.4%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the rate of major bleeding with warfarin?. ### Response: 3.4%.


Instruction: What was it with 60 mg of edoxaban?

Output: 2.8%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was it with 60 mg of edoxaban?. ### Response: 2.8%.


Instruction: What is the HR of warfarin?

Output: LOE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the HR of warfarin?. ### Response: LOE.


Instruction: What percentage of patients take edoxaban?

Output: 1.6%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients take edoxaban?. ### Response: 1.6%.


Instruction: How much of a risk is there for a stroke?

Output: 1.5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of a risk is there for a stroke?. ### Response: 1.5%.


Instruction: In the 2014 AF Guideline, what is the risk of having an isch-emic attack?

Output: prior transient

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the 2014 AF Guideline, what is the risk of having an isch-emic attack?. ### Response: prior transient.


Instruction: What was an indication to consider oral antico-agulants?

Output: the presence of a prior stroke, a prior transient isch-emic attack, or a CHA2DS2-VASc score of 2 or greater

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was an indication to consider oral antico-agulants?. ### Response: the presence of a prior stroke, a prior transient isch-emic attack, or a CHA2DS2-VASc score of 2 or greater.


Instruction: What are the COR and LOE of warfarin, dabigatran, and rivaroxaban?

Output: unchanged

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the COR and LOE of warfarin, dabigatran, and rivaroxaban?. ### Response: unchanged.


Instruction: What are the COR and LOE of warfarin, dabigatran, rivaroxaban, and apixaban unchanged from the 2014 AF Guideline?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the COR and LOE of warfarin, dabigatran, rivaroxaban, and apixaban unchanged from the 2014 AF Guideline?. ### Response: 2.


Instruction: How many RCTs have been comparing NOACs with warfarine?

Output: 4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs have been comparing NOACs with warfarine?. ### Response: 4.


Instruction: There was consistent evi-dence of at least what for the combined endpoint of stroke or systemic embolism?

Output: noninferiority

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There was consistent evi-dence of at least what for the combined endpoint of stroke or systemic embolism?. ### Response: noninferiority.


Instruction: When combined with a superior safety profile, they are recommended as what for eligible patients?

Output: firstline therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When combined with a superior safety profile, they are recommended as what for eligible patients?. ### Response: firstline therapy.


Instruction: The recommendation is similar to what?

Output: 2014 AF Guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The recommendation is similar to what?. ### Response: 2014 AF Guideline.


Instruction: New evidence has appeared that emphasizes the substantial variation across dif-ferent cohorts of patients with AF?

Output: overall stroke rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: New evidence has appeared that emphasizes the substantial variation across dif-ferent cohorts of patients with AF?. ### Response: overall stroke rates.


Instruction: What has been published about additional approaches to stroke risk prediction and serious net clinical outcome pre-diction in patients with AF?

Output: S4.1.1-40

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been published about additional approaches to stroke risk prediction and serious net clinical outcome pre-diction in patients with AF?. ### Response: S4.1.1-40.


Instruction: What have been published regarding specific anticoagulant management?

Output: Additional approaches to stroke risk prediction and serious net clinical outcome pre-diction in selected patients with AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have been published regarding specific anticoagulant management?. ### Response: Additional approaches to stroke risk prediction and serious net clinical outcome pre-diction in selected patients with AF.


Instruction: Anticoagulation for AF and hypertrophic cardiomyopathy remain the same as what?

Output: 2014 AF Guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Anticoagulation for AF and hypertrophic cardiomyopathy remain the same as what?. ### Response: 2014 AF Guideline.


Instruction: Patients with what type of heart valves were not included in studies validating the CHA2DS2-VASc scoring system?

Output: bioprosthetic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with what type of heart valves were not included in studies validating the CHA2DS2-VASc scoring system?. ### Response: bioprosthetic.


Instruction: What type of valves have very limited published experience for the use of?

Output: bioprosthetic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of valves have very limited published experience for the use of?. ### Response: bioprosthetic.


Instruction: What scoring system is used for long-term assessment of thromboembolism risk in patients with AF?

Output: CHA2DS2-VASc

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What scoring system is used for long-term assessment of thromboembolism risk in patients with AF?. ### Response: CHA2DS2-VASc.


Instruction: In 1 brief report, increasing age and the CHA2DS2-VASc score were independent predictors of what?

Output: thrombo-embolic events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In 1 brief report, increasing age and the CHA2DS2-VASc score were independent predictors of what?. ### Response: thrombo-embolic events.


Instruction: What was associated with low thromboembolic risk in patients with AF regardless of whether they had bioprosthetic valves?

Output: low CHA2DS2-VASc score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with low thromboembolic risk in patients with AF regardless of whether they had bioprosthetic valves?. ### Response: low CHA2DS2-VASc score.


Instruction: What is ARISTOTLE?

Output: Apixaban for Reduction  in Stroke and Other Thromboembolic Events in Atrial Fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ARISTOTLE?. ### Response: Apixaban for Reduction  in Stroke and Other Thromboembolic Events in Atrial Fibrillation.


Instruction: What is Fibrillation?

Output: Atrial FibrillationJuly 9, 2019 Circulation. 2019;140:e125–e151. DOI: 10.1161/CIR.0000000000000665 e132CLINICAL STATEMENTS  AND GUIDELINESFactor Xa Next Generation in Atrial Fibrillation—Thrombolysis in Myocardial Infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Fibrillation?. ### Response: Atrial FibrillationJuly 9, 2019 Circulation. 2019;140:e125–e151. DOI: 10.1161/CIR.0000000000000665 e132CLINICAL STATEMENTS  AND GUIDELINESFactor Xa Next Generation in Atrial Fibrillation—Thrombolysis in Myocardial Infarction.


Instruction: What is ENGAGE AF-TIMI 48?

Output: edoxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ENGAGE AF-TIMI 48?. ### Response: edoxaban.


Instruction: How many abstracts were searched for?

Output: 833

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many abstracts were searched for?. ### Response: 833.


Instruction: How many independent reviewers reviewed abstracts for acceptance into paper review?

Output: two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many independent reviewers reviewed abstracts for acceptance into paper review?. ### Response: two.


Instruction: How many papers were reviewed for inclusion in the guideline?

Output: 286

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many papers were reviewed for inclusion in the guideline?. ### Response: 286.


Instruction: How many accepted papers were sent to the full manuscript review?

Output: Ninety-six

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many accepted papers were sent to the full manuscript review?. ### Response: Ninety-six.


Instruction: What did the paper have to report to be included?

Output: data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the paper have to report to be included?. ### Response: data.


Instruction: How many manuscripts have been submitted?

Output: Ninety-six

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many manuscripts have been submitted?. ### Response: Ninety-six.


Instruction: How many papers have passed the mandatory in-clusion criteria?

Output: 286

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many papers have passed the mandatory in-clusion criteria?. ### Response: 286.


Instruction: How many manuscripts were included in the final review?

Output: Ninety-six

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many manuscripts were included in the final review?. ### Response: Ninety-six.


Instruction: What were 17 manuscripts published before 2000 that were considered to be sentinel papers?

Output: amanuscript

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were 17 manuscripts published before 2000 that were considered to be sentinel papers?. ### Response: amanuscript.


Instruction: How did individual members of the writing group read theretrieved references for their assigned topics?

Output: search technique

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did individual members of the writing group read theretrieved references for their assigned topics?. ### Response: search technique.


Instruction: What language articles contributed to the final recommendations?

Output: English

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What language articles contributed to the final recommendations?. ### Response: English.


Instruction: Why did only evidence relating to adult patients enter into the finalrecommendations?

Output: limited availabilityof high-quality evidence relating to pediatric patients hav-ing cardiac procedures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why did only evidence relating to adult patients enter into the finalrecommendations?. ### Response: limited availabilityof high-quality evidence relating to pediatric patients hav-ing cardiac procedures.


Instruction: Why did adult patients enter into the final recommendations?

Output: limited availabilityof high-quality evidence relating to pediatric patients hav-ing cardiac procedures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why did adult patients enter into the final recommendations?. ### Response: limited availabilityof high-quality evidence relating to pediatric patients hav-ing cardiac procedures.


Instruction: What was constructed to ensure that selected studies conformed to minimum re-quirements in terms of study design and reporting of out-comes?

Output: Evidence tables

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was constructed to ensure that selected studies conformed to minimum re-quirements in terms of study design and reporting of out-comes?. ### Response: Evidence tables.


Instruction: What is a representative evidence table evaluating theanticoagulation studies?

Output: Supplemental Table 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a representative evidence table evaluating theanticoagulation studies?. ### Response: Supplemental Table 1.


Instruction: What are studies of randomized controlled trials and meta-analyses shown in?

Output: Supplemental Table 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are studies of randomized controlled trials and meta-analyses shown in?. ### Response: Supplemental Table 2.


Instruction: What did members of the writing group write and develop based on review of the articles obtained using the search technique described above?

Output: rec-ommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did members of the writing group write and develop based on review of the articles obtained using the search technique described above?. ### Response: rec-ommendations.


Instruction: What allowed assess-ment of the level of evidence as recommended by theAmerican College?

Output: The quality ofinformation for a given reco mmendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What allowed assess-ment of the level of evidence as recommended by theAmerican College?. ### Response: The quality ofinformation for a given reco mmendation.


Instruction: What is the name of the Task Force on Practice Guidelines?

Output: American College of Cardiology Foundation/AmericanHeart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Practice Guidelines?. ### Response: American College of Cardiology Foundation/AmericanHeart Association.


Instruction: What does the Appendix contain a summary of?

Output: recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Appendix contain a summary of?. ### Response: recommendations.


Instruction: What is base.Heparin Dosing for Initiation and Maintenance ofCPBClass I Recommendation/C15A functional whole blood test of anticoagulation?

Output: the evidence base

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is base.Heparin Dosing for Initiation and Maintenance ofCPBClass I Recommendation/C15A functional whole blood test of anticoagulation?. ### Response: the evidence base.


Instruction: What is the effect of adrenaline on sur vival in out-of-hospital cardiac arrest?

Output: a randomised double-blind placebo-controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of adrenaline on sur vival in out-of-hospital cardiac arrest?. ### Response: a randomised double-blind placebo-controlled trial.


Instruction: What does rapid epinephrine admin-istration improve?

Output: early outcomes in out-of-hospital cardiac arrest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does rapid epinephrine admin-istration improve?. ### Response: early outcomes in out-of-hospital cardiac arrest.


Instruction: When did Resuscitation. 2013;84:915–20.

Output: Rapid epinephrine admin-istration improves early outcomes in out-of-hospital cardiac arrest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Resuscitation. 2013;84:915–20.. ### Response: Rapid epinephrine admin-istration improves early outcomes in out-of-hospital cardiac arrest.


Instruction: What are the outcomes in out-of-hospital cardiac arrest?

Output: early outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the outcomes in out-of-hospital cardiac arrest?. ### Response: early outcomes.


Instruction: What is the name of the double-blind trial of ligno-caine versus sotalol for acute termination of spontaneous sustained ventricular tachycardia?

Output: S6-26

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the double-blind trial of ligno-caine versus sotalol for acute termination of spontaneous sustained ventricular tachycardia?. ### Response: S6-26.


Instruction: When was the Lancet 344:18-23?

Output: 1994

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Lancet 344:18-23?. ### Response: 1994.


Instruction: What is lidocaine ver -sus intravenous amiodarone used for?

Output: incessant ventricular tachycardia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is lidocaine ver -sus intravenous amiodarone used for?. ### Response: incessant ventricular tachycardia.


Instruction: What is the name of the new aqueous formulation?

Output: Intravenous lidocaine ver -sus intravenous amiodarone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the new aqueous formulation?. ### Response: Intravenous lidocaine ver -sus intravenous amiodarone.


Instruction: Hassan TB, Jagger C, Barnett DB. A randomised trial to investigate the efficacy of what?

Output: magnesium sulphate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hassan TB, Jagger C, Barnett DB. A randomised trial to investigate the efficacy of what?. ### Response: magnesium sulphate.


Instruction: What is ventricular fibril-lation?

Output: refractory

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ventricular fibril-lation?. ### Response: refractory.


Instruction: What is the name of the randomised trial of magnesium in in-hospital cardiac arrest?

Output: GEMICA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised trial of magnesium in in-hospital cardiac arrest?. ### Response: GEMICA.


Instruction: When was the Lancet 350:1272-6?

Output: 1997

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Lancet 350:1272-6?. ### Response: 1997.


Instruction: What is the name of the study investigators in Buenos Aires, Argentina?

Output: GEMA Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study investigators in Buenos Aires, Argentina?. ### Response: GEMA Group.


Instruction: What is amiodarone used for in ven-tricular tachycardia?

Output: incessant ventricular tachycardia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is amiodarone used for in ven-tricular tachycardia?. ### Response: incessant ventricular tachycardia.


Instruction: What are the risks of intravenous verapamil for sustained ventricular tachycardia?

Output: Hazards

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the risks of intravenous verapamil for sustained ventricular tachycardia?. ### Response: Hazards.


Instruction: What is the name of the 2006 guideline for management of patients with ventricular arrhythmias?

Output: ACC/AHA/ESC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2006 guideline for management of patients with ventricular arrhythmias?. ### Response: ACC/AHA/ESC.


Instruction: What does the American College of Cardiology/American Heart Association Task Force do?

Output: guide-lines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the American College of Cardiology/American Heart Association Task Force do?. ### Response: guide-lines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death.


Instruction: What is the name of the group that did a report on sudden cardiac death?

Output: American College of Cardiology/American Heart Association Task Force

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that did a report on sudden cardiac death?. ### Response: American College of Cardiology/American Heart Association Task Force.


Instruction: What is the effect of cardiopul-monary resuscitation prior to defibrillation in patients with out-of-hospital ventricular fibrillation?

Output: Influence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of cardiopul-monary resuscitation prior to defibrillation in patients with out-of-hospital ventricular fibrillation?. ### Response: Influence.


Instruction: When did JAMA issue 281:1182-8. S6-34. Cobb LA, Weaver WD, Fahrenbruch CE, et al. Community-based interventions for sudden cardiac death. Impact, limitations, and changes.

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did JAMA issue 281:1182-8. S6-34. Cobb LA, Weaver WD, Fahrenbruch CE, et al. Community-based interventions for sudden cardiac death. Impact, limitations, and changes.. ### Response: 1999.


Instruction: What is a 3-phase time-sensitive model of resuscitation after cardiac arrest?

Output: Delaying defibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a 3-phase time-sensitive model of resuscitation after cardiac arrest?. ### Response: Delaying defibrillation.


Instruction: What is the name of the randomized trial of delaying defibrillation to give basic cardiopulmonary reanimation to patients with out-of-hospital ven-tricular fibrillation?

Output: Delaying defibrillation to give basic cardiopulmonary resuscitation to patients with out-of-hospital ven-tricular fibrillation: a randomized trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized trial of delaying defibrillation to give basic cardiopulmonary reanimation to patients with out-of-hospital ven-tricular fibrillation?. ### Response: Delaying defibrillation to give basic cardiopulmonary resuscitation to patients with out-of-hospital ven-tricular fibrillation: a randomized trial.


Instruction: What is the name of the randomized trial?

Output: Delaying defibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized trial?. ### Response: Delaying defibrillation.


Instruction: When was the JAMA 289:1389-95?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the JAMA 289:1389-95?. ### Response: 2003.


Instruction: What is part 8 of the 2010 American Heart Association guidelines?

Output: adult advanced cardio-vascular life support

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is part 8 of the 2010 American Heart Association guidelines?. ### Response: adult advanced cardio-vascular life support.


Instruction: What is the date of the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction?

Output: June 2020

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the date of the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction?. ### Response: June 2020.


Instruction: How old is the patient?

Output: 110 of 127

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old is the patient?. ### Response: 110 of 127.


Instruction: #5 Outcomes of interest Exp secondary prevention/ OR exp primary prevention/ Or exp morbidity/ OR ex death/ OR myocardial infarction/ OR cerebrovascular accident/ OR Angina, Unstable/ OR (stroke* OR (cerebrovascular ADJ accident* OR)) OR what other type of accident?

Output: #5 Outcomes of interest  Exp secondary prevention/ OR exp primary prevention/ OR exp mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: #5 Outcomes of interest Exp secondary prevention/ OR exp primary prevention/ Or exp morbidity/ OR ex death/ OR myocardial infarction/ OR cerebrovascular accident/ OR Angina, Unstable/ OR (stroke* OR (cerebrovascular ADJ accident* OR)) OR what other type of accident?. ### Response: #5 Outcomes of interest  Exp secondary prevention/ OR exp primary prevention/ OR exp mortality.


Instruction: What is the name of the event that causes angina?

Output: adverse ADJ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the event that causes angina?. ### Response: adverse ADJ.


Instruction: What is another name for heart ADJ attack?

Output: myocardial ADJ infarct

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for heart ADJ attack?. ### Response: myocardial ADJ infarct.


Instruction: What is another term for secondary ADJ prevention?

Output: ti,ab. OR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for secondary ADJ prevention?. ### Response: ti,ab. OR.


Instruction: What is a term for angina?

Output: Unstable

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a term for angina?. ### Response: Unstable.


Instruction: How is KQ 8 measured?

Output: change in lipid levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is KQ 8 measured?. ### Response: change in lipid levels.


Instruction: What does KQ 8 change in lipid levels?

Output: cholesteryl* OR cholesterol*

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does KQ 8 change in lipid levels?. ### Response: cholesteryl* OR cholesterol*.


Instruction: What is the name of the change in the lipid level?

Output: KQ 8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the change in the lipid level?. ### Response: KQ 8.


Instruction: How many Combine sets – without outcomes of interest?

Output: #7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many Combine sets – without outcomes of interest?. ### Response: #7.


Instruction: What is the limit to the number of Combine sets?

Output: #7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the limit to the number of Combine sets?. ### Response: #7.


Instruction: What is the limit to RCTs?

Output: #8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the limit to RCTs?. ### Response: #8.


Instruction: What are the limits to SRs/Meta -analyses hedge?

Output: #9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the limits to SRs/Meta -analyses hedge?. ### Response: #9.


Instruction: #10 Limit to cost studies 'health care cost'/exp OR 'cost effectiveness analysis'/economi*?

Output: costing OR price OR prices  OR saving OR savings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: #10 Limit to cost studies 'health care cost'/exp OR 'cost effectiveness analysis'/economi*?. ### Response: costing OR price OR prices  OR saving OR savings.


Instruction: What does 'quality adjusted life year' stand for?

Output: economic evaluation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does 'quality adjusted life year' stand for?. ### Response: economic evaluation.


Instruction: Price OR prices OR saving OR savings OR economi OR financial OR finance* OR pharmacoeconomic or QALYs OR (quality NEXT/1 adjusted next/1 life next/1 year*)?

Output: ti,ab

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Price OR prices OR saving OR savings OR economi OR financial OR finance* OR pharmacoeconomic or QALYs OR (quality NEXT/1 adjusted next/1 life next/1 year*)?. ### Response: ti,ab.


Instruction: Combine sets #6 AND (#8 OR #9) #12

Output: ti,ab  #11

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Combine sets #6 AND (#8 OR #9) #12. ### Response: ti,ab  #11.


Instruction: What is the name of the set that can be used to combine sets?

Output: #7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the set that can be used to combine sets?. ### Response: #7.


Instruction: What are the names of the sets that can't be combined?

Output: without outcomes of interest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the sets that can't be combined?. ### Response: without outcomes of interest.


Instruction: What is the name of the guideline for blood pressure measurement in patients with CKD?

Output: Chapter 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the guideline for blood pressure measurement in patients with CKD?. ### Response: Chapter 2.


Instruction: What is standardized auscultatory of fice-based BP?

Output: home oscillometric monitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is standardized auscultatory of fice-based BP?. ### Response: home oscillometric monitors.


Instruction: What is CKD G1 – G5 without kidney transplant?

Output: CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CKD G1 – G5 without kidney transplant?. ### Response: CKD.


Instruction: What are ambulatory BP and home oscillometric monitors?

Output: Oscillometric

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are ambulatory BP and home oscillometric monitors?. ### Response: Oscillometric.


Instruction: What is the diagnostic accuracy of various BP measurement techniques compared to standardized auscultatory of fice-based BP?

Output: Cost-effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the diagnostic accuracy of various BP measurement techniques compared to standardized auscultatory of fice-based BP?. ### Response: Cost-effectiveness.


Instruction: What type of BP is unattended or attended?

Output: Oscillometric (of ﬁce-based) BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of BP is unattended or attended?. ### Response: Oscillometric (of ﬁce-based) BP.


Instruction: What is the association among various variables in the general population?

Output: diagnostic accuracy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association among various variables in the general population?. ### Response: diagnostic accuracy.


Instruction: What is the association between different approaches to measuring BP in theclinic (standardized vs. non-standardized) and long-termoutcomes?

Output: classi ﬁcation of BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association between different approaches to measuring BP in theclinic (standardized vs. non-standardized) and long-termoutcomes?. ### Response: classi ﬁcation of BP.


Instruction: What type of monitors are used for BP monitoring at home?

Output: oscillometric

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of monitors are used for BP monitoring at home?. ### Response: oscillometric.


Instruction: What is the cost-effectiveness of fice-based blood pressure monitoring?

Output: Outcomes Cost-effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cost-effectiveness of fice-based blood pressure monitoring?. ### Response: Outcomes Cost-effectiveness.


Instruction: How does reducing protein intake compare to lowering blood pressure?

Output: improveclinically relevant outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does reducing protein intake compare to lowering blood pressure?. ### Response: improveclinically relevant outcomes.


Instruction: What does reducing protein intake do with CKD without diabetes?

Output: improveclinically relevant outcomes and decrease adverse effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does reducing protein intake do with CKD without diabetes?. ### Response: improveclinically relevant outcomes and decrease adverse effects.


Instruction: What type of diets are used to compare with a low-protein diet?

Output: Usual-protein diet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diets are used to compare with a low-protein diet?. ### Response: Usual-protein diet.


Instruction: How are outcomes listed in Table 1?

Output: Study design RCTs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are outcomes listed in Table 1?. ### Response: Study design RCTs.


Instruction: What does Hahn D, et al. recommend for non-diabetic adults with chronic kidney disease?

Output: Low protein diets

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Hahn D, et al. recommend for non-diabetic adults with chronic kidney disease?. ### Response: Low protein diets.


Instruction: What does reducing dietary salt intake do in adults without diabetes?

Output: improve clinically relevant outcomes and decrease adverse effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does reducing dietary salt intake do in adults without diabetes?. ### Response: improve clinically relevant outcomes and decrease adverse effects.


Instruction: What does low-salt diet compare to?

Output: Usual salt diet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does low-salt diet compare to?. ### Response: Usual salt diet.


Instruction: What are the outcomes listed in Table 1?

Output: Usual salt dietOutcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the outcomes listed in Table 1?. ### Response: Usual salt dietOutcomes.


Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020 Page 81 of 127 Appendix D : Patient Education on the Mediterranean Diet Table D-1?

Output: Eat More  Eat Less

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020 Page 81 of 127 Appendix D : Patient Education on the Mediterranean Diet Table D-1?. ### Response: Eat More  Eat Less.


Instruction: What type of diet is Mediterranean Diet?

Output: Patient Education

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diet is Mediterranean Diet?. ### Response: Patient Education.


Instruction: What kind of food is Seafood primarily fatty fish?

Output: poultry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What kind of food is Seafood primarily fatty fish?. ### Response: poultry.


Instruction: What type of oil is used to make low-fat milk and cheese?

Output: Olive

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of oil is used to make low-fat milk and cheese?. ### Response: Olive.


Instruction: What kind of meat is used for high-fat dairy and cheeses?

Output: Processed meat

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What kind of meat is used for high-fat dairy and cheeses?. ### Response: Processed meat.


Instruction: Trans fat * Providers should consider the risk of recommending what to individual patients?

Output: alcohol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Trans fat * Providers should consider the risk of recommending what to individual patients?. ### Response: alcohol.


Instruction: What does the use of RASi in patients with CKD G1 –G4 withA3 necessitate?

Output: patient education

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the use of RASi in patients with CKD G1 –G4 withA3 necessitate?. ### Response: patient education.


Instruction: What is vigilance to prevent?

Output: hyperkalemia and AKI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is vigilance to prevent?. ### Response: hyperkalemia and AKI.


Instruction: What is the goal of RASi treatment?

Output: preventing progressive loss of kidney function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the goal of RASi treatment?. ### Response: preventing progressive loss of kidney function.


Instruction: What are the costs and visits required for monitoring?

Output: higher healthcare costs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the costs and visits required for monitoring?. ### Response: higher healthcare costs.


Instruction: What is the insuf ficient in-formation to differentiate between men and women for thisrecommendation?

Output: ﬁcient

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the insuf ficient in-formation to differentiate between men and women for thisrecommendation?. ### Response: ﬁcient.


Instruction: What is there insufficient evidence that there aredifferent outcomes by race?

Output: 95% CIACEi Placebo/no treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is there insufficient evidence that there aredifferent outcomes by race?. ### Response: 95% CIACEi Placebo/no treatment.


Instruction: Why do we make this recommendation for RASi?

Output: because the bene ﬁtsof kidney and CV protection outweigh the potential adverserisks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why do we make this recommendation for RASi?. ### Response: because the bene ﬁtsof kidney and CV protection outweigh the potential adverserisks.


Instruction: What do most patients with CKD noton dialysis with severely increased albuminuria but without diabetes opt for?

Output: treatment with RASi

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do most patients with CKD noton dialysis with severely increased albuminuria but without diabetes opt for?. ### Response: treatment with RASi.


Instruction: What do patients put a large value on?

Output: cardio- and renoprotectivebeneﬁts of RASi

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do patients put a large value on?. ### Response: cardio- and renoprotectivebeneﬁts of RASi.


Instruction: What are some of the potential harms of ACEi?

Output: hyperkalemia and AKI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the potential harms of ACEi?. ### Response: hyperkalemia and AKI.


Instruction: What may lead to higher healthcare costs from additional visits and laboratory testing?

Output: side effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may lead to higher healthcare costs from additional visits and laboratory testing?. ### Response: side effects.


Instruction: What is the risk ratio for treatment?

Output: 95%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk ratio for treatment?. ### Response: 95%.


Instruction: What is a 95% CI for treatmentRisk ratio?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a 95% CI for treatmentRisk ratio?. ### Response: 941423007821699693143163.


Instruction: How many events are there?

Output: 6.51]0.45 [0.23, 0.90]0.59 [0.10, 3.43]0.58 [0.36, 0.93]Figure 6 | Cardiovascular events in patients with CKD G3 –G4, A3 without diabetes. Meta-analysis was conducted by the Cochrane Kidneyand Transplant Evidence Review Team as part of the guideline evidence review. GISEN reported data from the REIN Stratum-2 group (baselineproteinuria $3 g/24 h), in contrast to REIN Stratum-1 (baseline proteinuria 1-3 g/24 h). A3, severely increased albuminuria; ACEi, angiotensin-converting enzyme inhibitor; AIPRI, Angiotensin-Converting Enzyme Inhibitors and Kidney Protection; CI, con ﬁdence interval; CKD, chronickidney disease; events, number of events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many events are there?. ### Response: 6.51]0.45 [0.23, 0.90]0.59 [0.10, 3.43]0.58 [0.36, 0.93]Figure 6 | Cardiovascular events in patients with CKD G3 –G4, A3 without diabetes. Meta-analysis was conducted by the Cochrane Kidneyand Transplant Evidence Review Team as part of the guideline evidence review. GISEN reported data from the REIN Stratum-2 group (baselineproteinuria $3 g/24 h), in contrast to REIN Stratum-1 (baseline proteinuria 1-3 g/24 h). A3, severely increased albuminuria; ACEi, angiotensin-converting enzyme inhibitor; AIPRI, Angiotensin-Converting Enzyme Inhibitors and Kidney Protection; CI, con ﬁdence interval; CKD, chronickidney disease; events, number of events.


Instruction: Who conducted a meta-analysis of patients with CKD G3 -G4, A3 without diabetes?

Output: Cochrane Kidneyand Transplant Evidence Review Team

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who conducted a meta-analysis of patients with CKD G3 -G4, A3 without diabetes?. ### Response: Cochrane Kidneyand Transplant Evidence Review Team.


Instruction: What group reported data from REIN Stratum-2 group?

Output: GISEN

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What group reported data from REIN Stratum-2 group?. ### Response: GISEN.


Instruction: What group reported data from the REIN Stratum-2 group?

Output: GISEN

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What group reported data from the REIN Stratum-2 group?. ### Response: GISEN.


Instruction: What did GISEN report data from?

Output: REIN Stratum-2 group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did GISEN report data from?. ### Response: REIN Stratum-2 group.


Instruction: How much is the baseline proteinuria in REIN stratum-2?

Output: $3 g

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much is the baseline proteinuria in REIN stratum-2?. ### Response: $3 g.


Instruction: A3 severely increased what?

Output: albuminuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A3 severely increased what?. ### Response: albuminuria.


Instruction: What does CKD stand for?

Output: chronickidney disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CKD stand for?. ### Response: chronickidney disease.


Instruction: What is the acronym for Chronic Kidney Disease?

Output: CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Chronic Kidney Disease?. ### Response: CKD.


Instruction: Who is the Italian name for Mantel-Haenszel?

Output: M-H

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Italian name for Mantel-Haenszel?. ### Response: M-H.


Instruction: What were the complication rates among diabetic patients with moderate glycemic control with glucose levels of 127 to 179 mg/dL?

Output: lowest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the complication rates among diabetic patients with moderate glycemic control with glucose levels of 127 to 179 mg/dL?. ### Response: lowest.


Instruction: Patients with diabetes mellitus have less favorable long-term outcomes after CABG compared with nondiabetic patients?

Output: 278

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with diabetes mellitus have less favorable long-term outcomes after CABG compared with nondiabetic patients?. ### Response: 278.


Instruction: What type of patients have less favorable long-term outcomes after CABG than non-diabetic patients?

Output: Patients with diabetes mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of patients have less favorable long-term outcomes after CABG than non-diabetic patients?. ### Response: Patients with diabetes mellitus.


Instruction: What is not well understood to be attributable to a general progression of cardiovascu-lar disease seen in diabetic patients or CABG patients with poorly controlled diabetes mellitus?

Output: diminished long-term survival and freedom from adverse cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not well understood to be attributable to a general progression of cardiovascu-lar disease seen in diabetic patients or CABG patients with poorly controlled diabetes mellitus?. ### Response: diminished long-term survival and freedom from adverse cardiovascular events.


Instruction: What do CABG patients with poorly controlled diabetes mellitus have that make them prone to diminished long-term survival?

Output: characteris-tics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do CABG patients with poorly controlled diabetes mellitus have that make them prone to diminished long-term survival?. ### Response: characteris-tics.


Instruction: How do glucocorticoids cause hypertension?

Output: role of nitric oxide deficiency, oxidative stress, and eicosanoids

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do glucocorticoids cause hypertension?. ### Response: role of nitric oxide deficiency, oxidative stress, and eicosanoids.


Instruction: What does Ong SLH, Whitworth JA, and eicosanoids do?

Output: glucocorticoids cause hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Ong SLH, Whitworth JA, and eicosanoids do?. ### Response: glucocorticoids cause hypertension.


Instruction: When did Endocrinol Metab Clin North Am. 2011;40: 393–407; ix. S5.4.1-4.

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Endocrinol Metab Clin North Am. 2011;40: 393–407; ix. S5.4.1-4.. ### Response: 2013.


Instruction: Maniero C, et al. Drug-related hypertension and resistance to antihypertensive treatment: a call for action.

Output: J Hypertens. 2011;29:2295–309

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Maniero C, et al. Drug-related hypertension and resistance to antihypertensive treatment: a call for action.. ### Response: J Hypertens. 2011;29:2295–309.


Instruction: Tachjian A, Maria V, Jahangir A. Use of herbal products and poten-tial interactions in patients with cardiovascular diseases.

Output: 2295–309

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Tachjian A, Maria V, Jahangir A. Use of herbal products and poten-tial interactions in patients with cardiovascular diseases.. ### Response: 2295–309.


Instruction: What is secondary hypertension: interfering substances?

Output: Secondary hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is secondary hypertension: interfering substances?. ### Response: Secondary hypertension.


Instruction: What is a guideline for healthcare profesions from the American Heart Association?

Output: Guidelines for the primary prevention of stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a guideline for healthcare profesions from the American Heart Association?. ### Response: Guidelines for the primary prevention of stroke.


Instruction: What is the acronym for the American Heart Association/American Stroke Association?

Output: Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the American Heart Association/American Stroke Association?. ### Response: Stroke.


Instruction: When was the last time a child was treated with ADHD medications?

Output: 2295–309

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last time a child was treated with ADHD medications?. ### Response: 2295–309.


Instruction: What was the name of the 2013 study that reviewed the management of ADHD in children and adolescents?

Output: J Child Psychol Psychiatry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the 2013 study that reviewed the management of ADHD in children and adolescents?. ### Response: J Child Psychol Psychiatry.


Instruction: What is a clinical practice guideline for the diagnosis, evaluation, and treatment of ADHD in children and adolescents?

Output: Practitioner review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a clinical practice guideline for the diagnosis, evaluation, and treatment of ADHD in children and adolescents?. ### Response: Practitioner review.


Instruction: What is the name of the journal that published a review of recent evidence regarding the use of antipsy-chotic medications?

Output: J Clin Psychiatry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that published a review of recent evidence regarding the use of antipsy-chotic medications?. ### Response: J Clin Psychiatry.


Instruction: What is a review of recent evidence about medications?

Output: Metabolic considerations in the use of antipsy-chotic medications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a review of recent evidence about medications?. ### Response: Metabolic considerations in the use of antipsy-chotic medications.


Instruction: What is the name of the study that examined the population attributable risks of hypertension and diabetes for cardiovascular disease and stroke?

Output: northern Manhattan study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined the population attributable risks of hypertension and diabetes for cardiovascular disease and stroke?. ### Response: northern Manhattan study.


Instruction: How does coffee affect blood pressure and cardiovascular disease in hypertensive individuals?

Output: The effect of coffee on blood pressure and cardiovascular disease in hypertensive individuals: a systematic review and meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does coffee affect blood pressure and cardiovascular disease in hypertensive individuals?. ### Response: The effect of coffee on blood pressure and cardiovascular disease in hypertensive individuals: a systematic review and meta-analysis.


Instruction: What is the name of the systematic review and meta-analysis of the effect of coffee on blood pressure?

Output: Mesas AE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta-analysis of the effect of coffee on blood pressure?. ### Response: Mesas AE.


Instruction: When was the Am J Clin Nutr. 201194:1113-26?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Am J Clin Nutr. 201194:1113-26?. ### Response: 2011.


Instruction: What is the primary immunosuppression for lung transplant recipients?

Output: Tacrolimus versus cyclosporin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary immunosuppression for lung transplant recipients?. ### Response: Tacrolimus versus cyclosporin.


Instruction: What is cyclosporin?

Output: primary immunosuppression

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is cyclosporin?. ### Response: primary immunosuppression.


Instruction: What is tacrolimus and cyclo-sporine used for after renal transplantation?

Output: metabolic syndrome and cardiovascular risk factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is tacrolimus and cyclo-sporine used for after renal transplantation?. ### Response: metabolic syndrome and cardiovascular risk factors.


Instruction: What is the name of the meta-analysis that examined the effects on metabolic syndrome and cardiovascular risk factors?

Output: Xue W, Zhang Q, Xu Y , et al. Effects of tacrolimus and cyclo-sporine treatment on metabolic syndrome and cardiovascular risk factors after renal transplantation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis that examined the effects on metabolic syndrome and cardiovascular risk factors?. ### Response: Xue W, Zhang Q, Xu Y , et al. Effects of tacrolimus and cyclo-sporine treatment on metabolic syndrome and cardiovascular risk factors after renal transplantation.


Instruction: What is the 2013 ESH/ESC guide-lines for the management of arterial hypertension called?

Output: the Task Force for the Management of Arterial Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2013 ESH/ESC guide-lines for the management of arterial hypertension called?. ### Response: the Task Force for the Management of Arterial Hypertension.


Instruction: What does ESH stand for?

Output: European Society of Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ESH stand for?. ### Response: European Society of Hypertension.


Instruction: Who is the Task Force for the Management of Arterial Hypertension?

Output: European Society of Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Task Force for the Management of Arterial Hypertension?. ### Response: European Society of Hypertension.


Instruction: What can CTEPH who are not candidates for pulmonarythromboendarterectomy benefit from?

Output: othermechanical and pharmacological interventions designedto lower pulmonary arterial pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can CTEPH who are not candidates for pulmonarythromboendarterectomy benefit from?. ### Response: othermechanical and pharmacological interventions designedto lower pulmonary arterial pressure.


Instruction: What are othermechanical and pharmacological interventions designed to lower?

Output: pulmonary arterial pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are othermechanical and pharmacological interventions designed to lower?. ### Response: pulmonary arterial pressure.


Instruction: What could improve short- and long-termvenous patency?

Output: thrombolysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could improve short- and long-termvenous patency?. ### Response: thrombolysis.


Instruction: What does thrombolysis reduce?

Output: PTS of the arm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does thrombolysis reduce?. ### Response: PTS of the arm.


Instruction: In patients with UEDVT who were treated withthrombolytic therapy, what does it do?

Output: bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with UEDVT who were treated withthrombolytic therapy, what does it do?. ### Response: bleeding.


Instruction: What is complex and costly compared to anticoagulation alone?

Output: thrombolytic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is complex and costly compared to anticoagulation alone?. ### Response: thrombolytic therapy.


Instruction: What is most likely to be of bene fitin patients who meet the following criteria?

Output: thrombolysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is most likely to be of bene fitin patients who meet the following criteria?. ### Response: thrombolysis.


Instruction: How long is the life expectancy of CDT?

Output: $1 year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the life expectancy of CDT?. ### Response: $1 year.


Instruction: What did we suggest over systemicthrombolysis to reduce the dose of thrombolytic drugand the risk of bleeding?

Output: CDT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did we suggest over systemicthrombolysis to reduce the dose of thrombolytic drugand the risk of bleeding?. ### Response: CDT.


Instruction: What does systemic thrombolysis increase in patients with acute PE?

Output: bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does systemic thrombolysis increase in patients with acute PE?. ### Response: bleeding.


Instruction: What can CDT accelerate breakdown of acutePE?

Output: low-quality evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can CDT accelerate breakdown of acutePE?. ### Response: low-quality evidence.


Instruction: How does this evidence have a bearing on patients with UEDVT?

Output: indirect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does this evidence have a bearing on patients with UEDVT?. ### Response: indirect.


Instruction: What is the grade of thrombolysis in patients with UEDVT?

Output: Grade 2C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the grade of thrombolysis in patients with UEDVT?. ### Response: Grade 2C.


Instruction: What are patients who are most likely to benefit from thromblysis?

Output: patients who meet the following criteria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients who are most likely to benefit from thromblysis?. ### Response: patients who meet the following criteria.


Instruction: What type of therapy is most likely to benefit from thrombolysis?

Output: bolytic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is most likely to benefit from thrombolysis?. ### Response: bolytic.


Instruction: What is a high value attached to prevention of?

Output: PTS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a high value attached to prevention of?. ### Response: PTS.


Instruction: Patients with UEDVT who undergothrombolytic therapy are likely to choose what?

Output: thrombolytic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with UEDVT who undergothrombolytic therapy are likely to choose what?. ### Response: thrombolytic therapy.


Instruction: What does thrombolytic therapy over anticoagulationalone do?

Output: complex and costly

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does thrombolytic therapy over anticoagulationalone do?. ### Response: complex and costly.


Instruction: In patients with UEDVT who undergothrombolysis, we recommend the same intensityand duration of anticoagulant therapy as in patients who do not undergo what?

Output: thrombolysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with UEDVT who undergothrombolysis, we recommend the same intensityand duration of anticoagulant therapy as in patients who do not undergo what?. ### Response: thrombolysis.


Instruction: What are there no randomized trials or prospective cohortstudies that have evaluated management of patients withrecurrent VTE?

Output: anticoagulant therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are there no randomized trials or prospective cohortstudies that have evaluated management of patients withrecurrent VTE?. ### Response: anticoagulant therapy.


Instruction: How many broad categories can risk factors for recurrent VTE while on anticoagulanttherapy be divided into?

Output: two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many broad categories can risk factors for recurrent VTE while on anticoagulanttherapy be divided into?. ### Response: two.


Instruction: What are the two broad categories of factors?

Output: treatment factors and (2) the patient ’s intrinsic riskof recurrence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the two broad categories of factors?. ### Response: treatment factors and (2) the patient ’s intrinsic riskof recurrence.


Instruction: What is the patient's intrinsic risk of recurrence?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the patient's intrinsic risk of recurrence?. ### Response: 2.