Instruction: What type of screening can identify other family members with elevated LDL-C?

Output: cascade screening

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of screening can identify other family members with elevated LDL-C?. ### Response: cascade screening.


Instruction: Even moderate hypercholesterolemia can accelerate development of what?

Output: atherosclerosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Even moderate hypercholesterolemia can accelerate development of what?. ### Response: atherosclerosis.


Instruction: What should be addressed appropriately?

Output: Sec-ondary causes of elevated cholesterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be addressed appropriately?. ### Response: Sec-ondary causes of elevated cholesterol.


Instruction: What suggests genetic forms of hypercholesterolemia?

Output: Elevations of LDL-C persisting af-ter excluding secondary causes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What suggests genetic forms of hypercholesterolemia?. ### Response: Elevations of LDL-C persisting af-ter excluding secondary causes.


Instruction: Young adults who experience prolonged exposure to hyperlipidemia prior to age 55 are shown to have what?

Output: significantly increased risk of coro-nary heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Young adults who experience prolonged exposure to hyperlipidemia prior to age 55 are shown to have what?. ### Response: significantly increased risk of coro-nary heart disease.


Instruction: What has significantly increased risk of coro-nary heart disease?

Output: Young adults who experience prolonged exposure to hyperlipidemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has significantly increased risk of coro-nary heart disease?. ### Response: Young adults who experience prolonged exposure to hyperlipidemia.


Instruction: What has the potential to reduce the hyperlipidemia and associated ASCVD risk factor burden?

Output: Intensive lifestyle change

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has the potential to reduce the hyperlipidemia and associated ASCVD risk factor burden?. ### Response: Intensive lifestyle change.


Instruction: Young adults with persistent, moderate hypercholesterolemia (LDL-C 160-189 mg/dL) are a smaller group but at what risk?

Output: higher risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Young adults with persistent, moderate hypercholesterolemia (LDL-C 160-189 mg/dL) are a smaller group but at what risk?. ### Response: higher risk.


Instruction: What is an example of a risk-enhancing factor?

Output: family history of premature AS-CVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a risk-enhancing factor?. ### Response: family history of premature AS-CVD.


Instruction: Why is there an increased probability of genetic FH in this LDL-C range?

Output: clinical judgment would suggest that these high risk young adults will benefit from long-term statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is there an increased probability of genetic FH in this LDL-C range?. ### Response: clinical judgment would suggest that these high risk young adults will benefit from long-term statin therapy.


Instruction: What type of therapy would high risk young adults benefit from?

Output: statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy would high risk young adults benefit from?. ### Response: statin therapy.


Instruction: Long-term statin therapy has been shown that those with higher LDL-C can gain as much or more benefit from what?

Output: cholesterol re-duction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Long-term statin therapy has been shown that those with higher LDL-C can gain as much or more benefit from what?. ### Response: cholesterol re-duction.


Instruction: In young adults without phenotypical severe hy-percholesterolemia, risk assessment should begin by estimation of how many lifetimes?

Output: 21 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In young adults without phenotypical severe hy-percholesterolemia, risk assessment should begin by estimation of how many lifetimes?. ### Response: 21 years.


Instruction: What should risk assessment begin with?

Output: estimation of lifetime risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should risk assessment begin with?. ### Response: estimation of lifetime risk.


Instruction: What can be used to estimate lifetime risk starting at age 21 years?

Output: The pooled cohort equations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be used to estimate lifetime risk starting at age 21 years?. ### Response: The pooled cohort equations.


Instruction: To improve high-risk lifestyle behaviors including tobacco use, sedentary lifestyle and/or poor diet?

Output: pooled cohort equations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: To improve high-risk lifestyle behaviors including tobacco use, sedentary lifestyle and/or poor diet?. ### Response: pooled cohort equations.


Instruction: When young adults with hyper-cholesterolemia or multiple risk factors are identified, what is indicated?

Output: lifestyle intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When young adults with hyper-cholesterolemia or multiple risk factors are identified, what is indicated?. ### Response: lifestyle intervention.


Instruction: To date, no long-term RCTs with cholesterol-lowering drugs have been carried out in what age group?

Output: 20 to 39 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: To date, no long-term RCTs with cholesterol-lowering drugs have been carried out in what age group?. ### Response: 20 to 39 years.


Instruction: What is the age range of the primary prevention RCT?

Output: low to moderate short-term risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the age range of the primary prevention RCT?. ### Response: low to moderate short-term risk.


Instruction: What has been proposed in those younger individuals at low to moderate short-term risk but at high lifetime risk?

Output: a primary prevention RCT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been proposed in those younger individuals at low to moderate short-term risk but at high lifetime risk?. ### Response: a primary prevention RCT.


Instruction: What would be used to detect significant coronary atherosclerosis with CAC scores?

Output: statins or drug combination

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would be used to detect significant coronary atherosclerosis with CAC scores?. ### Response: statins or drug combination.


Instruction: What has been suggested for this purpose?

Output: statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been suggested for this purpose?. ### Response: statin therapy.


Instruction: What does the Department of Veterans Affairs do?

Output: 10.1161/CIRCULATIONAHA.120.052209 226

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Department of Veterans Affairs do?. ### Response: 10.1161/CIRCULATIONAHA.120.052209 226.


Instruction: What does icosapent ethyl do for hypertriglyceridemia?

Output: Cardiovascular risk reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does icosapent ethyl do for hypertriglyceridemia?. ### Response: Cardiovascular risk reduction.


Instruction: What is eicosapent ethyl used for?

Output: hypertriglyceridemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is eicosapent ethyl used for?. ### Response: hypertriglyceridemia.


Instruction: What is the name of the drug used to treat hypertriglyceridemia?

Output: Medical nutrition therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used to treat hypertriglyceridemia?. ### Response: Medical nutrition therapy.


Instruction: How many people in Japan have had strokes?

Output: 220

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people in Japan have had strokes?. ### Response: 220.


Instruction: Where is the JELIS Investigators located?

Output: Japan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the JELIS Investigators located?. ### Response: Japan.


Instruction: What is eicosapentaenoic acid used for in hypercholesterolemic patients?

Output: Reduction in the recurrence of stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is eicosapentaenoic acid used for in hypercholesterolemic patients?. ### Response: Reduction in the recurrence of stroke.


Instruction: What is the name of the subanalysis of the JELIS trial?

Output: JELIS Investigators, Japan. Reduction in the recurrence of stroke by eicosapentaenoic acid for hypercholesterolemic patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the subanalysis of the JELIS trial?. ### Response: JELIS Investigators, Japan. Reduction in the recurrence of stroke by eicosapentaenoic acid for hypercholesterolemic patients.


Instruction: How long was the MARINE trial?

Output: 12-week

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the MARINE trial?. ### Response: 12-week.


Instruction: What is the name of the multi-center, plA-cebo-controlled, Randomized, double-blINd, 12-week study with an open-label extension?

Output: MARINE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multi-center, plA-cebo-controlled, Randomized, double-blINd, 12-week study with an open-label extension?. ### Response: MARINE.


Instruction: When was the Am J Cardiol.108:682-690?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Am J Cardiol.108:682-690?. ### Response: 2011.


Instruction: What is the essential cornerstone for effective treat-ment of “refractory” severe hypertriglyceridemia?

Output: Medical nutrition therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the essential cornerstone for effective treat-ment of “refractory” severe hypertriglyceridemia?. ### Response: Medical nutrition therapy.


Instruction: What is the essential cornerstone for effective treatment of hypertriglyceridemia?

Output: Medical nutrition therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the essential cornerstone for effective treatment of hypertriglyceridemia?. ### Response: Medical nutrition therapy.


Instruction: Evidence from a lipid management program.

Output: Eicosapentaenoic acid ethyl ester (AMR101) therapy in patients with very high triglyceride levels (from the Multi-center, plA-cebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Evidence from a lipid management program.. ### Response: Eicosapentaenoic acid ethyl ester (AMR101) therapy in patients with very high triglyceride levels (from the Multi-center, plA-cebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] trial.


Instruction: What is the name of the randomized clinical trial that evaluated the effect of high-dose omega-3 fatty acids vs corn oil on major adverse cardiovascular events in patients at high cardiovascular risk?

Output: STRENGTH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized clinical trial that evaluated the effect of high-dose omega-3 fatty acids vs corn oil on major adverse cardiovascular events in patients at high cardiovascular risk?. ### Response: STRENGTH.


Instruction: How many studies have been conducted on the STRENGTH trial?

Output: 225

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies have been conducted on the STRENGTH trial?. ### Response: 225.


Instruction: What does n-3 fatty acid supplements do in elderly patients after myocardial infarc-tion?

Output: Effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does n-3 fatty acid supplements do in elderly patients after myocardial infarc-tion?. ### Response: Effects.


Instruction: What is the name of the randomized, controlled trial?

Output: Multi-center, plA-cebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized, controlled trial?. ### Response: Multi-center, plA-cebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] trial.


Instruction: What is the name of the disease caused by hypertriglyceridemia?

Output: pancreatitis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease caused by hypertriglyceridemia?. ### Response: pancreatitis.


Instruction: What is one of the reasons for the interaction of familial and secondary causes?

Output: role in pancreatitis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the reasons for the interaction of familial and secondary causes?. ### Response: role in pancreatitis.


Instruction: Who is the author of the paper?

Output: Tanaka K

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of the paper?. ### Response: Tanaka K.


Instruction: Who represents the American Heart Association Clinical Pharmacology Committee of the Council on Clinical Cardiology?

Output: Wiggins BS, Saseen JJ, Page RL 2nd, Reed BN, Sneed K, Kostis JB, Lanfear D, Virani S, Morris PB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who represents the American Heart Association Clinical Pharmacology Committee of the Council on Clinical Cardiology?. ### Response: Wiggins BS, Saseen JJ, Page RL 2nd, Reed BN, Sneed K, Kostis JB, Lanfear D, Virani S, Morris PB.


Instruction: Who represents Council on Hypertension?

Output: American Heart Association Clinical Pharmacology Committee of the Council on Clinical Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who represents Council on Hypertension?. ### Response: American Heart Association Clinical Pharmacology Committee of the Council on Clinical Cardiology.


Instruction: Who is Professor of Medicine, Division of Cardiology, Medical Director for Quality, Vanderbilt Heart & Vascular Institute, and Associate Medical Director, Cardiovascular ICUN?

Output: Sidney C. Smith Jr

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Professor of Medicine, Division of Cardiology, Medical Director for Quality, Vanderbilt Heart & Vascular Institute, and Associate Medical Director, Cardiovascular ICUN?. ### Response: Sidney C. Smith Jr.


Instruction: What is the name of the professor of medicine at the University of North Carolina, Chapel Hill?

Output: Sidney C. Smith Jr

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor of medicine at the University of North Carolina, Chapel Hill?. ### Response: Sidney C. Smith Jr.


Instruction: Who is Professor of Cardiovascular Research at Baylor College of Medicine?

Output: Salim S. Virani

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Professor of Cardiovascular Research at Baylor College of Medicine?. ### Response: Salim S. Virani.


Instruction: What is Michael E. DeBakey VA Medical Center's job title?

Output: Staff Cardiologist and Investigator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Michael E. DeBakey VA Medical Center's job title?. ### Response: Staff Cardiologist and Investigator.


Instruction: What is the name of the professor and chief of Rush Medical College?

Output: Kim A. Williams Sr Rush Medical College—James B. Herrick

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor and chief of Rush Medical College?. ### Response: Kim A. Williams Sr Rush Medical College—James B. Herrick.


Instruction: When was this article downloaded?

Output: May 1, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this article downloaded?. ### Response: May 1, 2023.


Instruction: What is the Incremental value of the exercise test for diagnosing the presence or absence of coronary artery disease?

Output: EstimatingPretest Probability

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Incremental value of the exercise test for diagnosing the presence or absence of coronary artery disease?. ### Response: EstimatingPretest Probability.


Instruction: When did Diamond GA, Forrester JS, Hirsch M, et al. apply conditionalprobability analysis to the clinical diagnosis of CAD?

Output: 1985

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Diamond GA, Forrester JS, Hirsch M, et al. apply conditionalprobability analysis to the clinical diagnosis of CAD?. ### Response: 1985.


Instruction: What is a low diagnostic yield of elective coronaryangiography?

Output: Diamond GA, Kaul S. Low diagnostic yield of elective coronaryangiography. N Engl J Med. 2010;363:93–5.91

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a low diagnostic yield of elective coronaryangiography?. ### Response: Diamond GA, Kaul S. Low diagnostic yield of elective coronaryangiography. N Engl J Med. 2010;363:93–5.91.


Instruction: What is an alternative diag nosticstrategies for coronary artery disease?

Output: Tradi-tional Age, Sex, and Angina Typicality-Based Approach for EstimatingPretest Probability of Angiographically Significant Coronary ArteryDisease in Patients Undergoing Coronary Computed TomographicAngiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an alternative diag nosticstrategies for coronary artery disease?. ### Response: Tradi-tional Age, Sex, and Angina Typicality-Based Approach for EstimatingPretest Probability of Angiographically Significant Coronary ArteryDisease in Patients Undergoing Coronary Computed TomographicAngiography.


Instruction: What is low diagnostic yield of elective coronaryangiography?

Output: Low diagnostic yield of elective coronaryangiography. N Engl J Med. 2010;363:93–5.91

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is low diagnostic yield of elective coronaryangiography?. ### Response: Low diagnostic yield of elective coronaryangiography. N Engl J Med. 2010;363:93–5.91.


Instruction: What is exercise echocardiography or exercise SPECT imaging?

Output: A meta-analysis of diagnostictest performance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is exercise echocardiography or exercise SPECT imaging?. ### Response: A meta-analysis of diagnostictest performance.


Instruction: What are the results from the Multinational Coronary CTAngiography Evaluation for Clinical Outcomes: An International Mul-ticenter Registry?

Output: Angiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results from the Multinational Coronary CTAngiography Evaluation for Clinical Outcomes: An International Mul-ticenter Registry?. ### Response: Angiography.


Instruction: What is the name of the journal that studies the risks of cancer from computed tomographic scans in the United States in 2007?

Output: Arch Intern Med.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies the risks of cancer from computed tomographic scans in the United States in 2007?. ### Response: Arch Intern Med..


Instruction: What year did the Arch Intern Med publish a report on cancer risks?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did the Arch Intern Med publish a report on cancer risks?. ### Response: 2009.


Instruction: How did Gerber TC, Gibbons RJ weigh the risks and benefits of cardiac imaging with ionizing radiation?

Output: Weighing the risks and benefits

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Gerber TC, Gibbons RJ weigh the risks and benefits of cardiac imaging with ionizing radiation?. ### Response: Weighing the risks and benefits.


Instruction: What is ionizing radiation used for in cardiac imaging?

Output: a science advisory

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ionizing radiation used for in cardiac imaging?. ### Response: a science advisory.


Instruction: What is the risk of myocardial perfusion scans in the United States?

Output: projected population cancer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of myocardial perfusion scans in the United States?. ### Response: projected population cancer.


Instruction: What does Abbara S, Chen MY, et al. say about SCCT guidelines on radiation dose and dose-optimization strategies in cardiovascular CT?

Output: Halliburton SS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Abbara S, Chen MY, et al. say about SCCT guidelines on radiation dose and dose-optimization strategies in cardiovascular CT?. ### Response: Halliburton SS.


Instruction: What does Cerqueira MD, Allman KC, Ficaro EP, and others say about radiation exposure in myocardial perfusion imaging?

Output: Recommendations forreducing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Cerqueira MD, Allman KC, Ficaro EP, and others say about radiation exposure in myocardial perfusion imaging?. ### Response: Recommendations forreducing.


Instruction: What is ionizing radiation used for in cardiacimaging?

Output: a science advisory

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ionizing radiation used for in cardiacimaging?. ### Response: a science advisory.


Instruction: What is the name of the committee on Cardiac Imaging of the Council on Clinical Cardiology?

Output: Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the committee on Cardiac Imaging of the Council on Clinical Cardiology?. ### Response: Committee.


Instruction: What is the name of the multicenter trial of high-speedversus conventional single-photon emission computed tomo graphyimaging?

Output: Multinational Coronary CTAngiography Evaluation for Clinical Outcomes: An International Mul-ticenter Registry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multicenter trial of high-speedversus conventional single-photon emission computed tomo graphyimaging?. ### Response: Multinational Coronary CTAngiography Evaluation for Clinical Outcomes: An International Mul-ticenter Registry.


Instruction: What are the quantitative results of myocardial perfusion and left ventricular function?

Output: Multicenter trial of high-speedversus conventional single-photon emission computed tomo graphyimaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the quantitative results of myocardial perfusion and left ventricular function?. ### Response: Multicenter trial of high-speedversus conventional single-photon emission computed tomo graphyimaging.


Instruction: When was the J Am Coll Cardiol 55:1965–74.100?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol 55:1965–74.100?. ### Response: 2010.


Instruction: What is the name of the 2021 guideline for the secondary prevention of Ischemic Stroke?

Output: GUIDELINESKleindorfer et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2021 guideline for the secondary prevention of Ischemic Stroke?. ### Response: GUIDELINESKleindorfer et al.


Instruction: What does not support a causal association with increased risk of thromboembolism?

Output: disk aortic valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not support a causal association with increased risk of thromboembolism?. ### Response: disk aortic valve replacement.


Instruction: There is no conclusive evidence supporting a causal association between native aortic valve disease and increased risk of stroke or TIA.

Output: 478,479

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is no conclusive evidence supporting a causal association between native aortic valve disease and increased risk of stroke or TIA.. ### Response: 478,479.


Instruction: What are additional distinct valvular lesions such as Libman-Sacks endocarditis?

Output: 486 age-related calcifications,487 or bicuspid aortic valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are additional distinct valvular lesions such as Libman-Sacks endocarditis?. ### Response: 486 age-related calcifications,487 or bicuspid aortic valves.


Instruction: Alter-related calcifications and what other lesions have been associated with higher risk of thromboembolism?

Output: bicuspid aortic valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Alter-related calcifications and what other lesions have been associated with higher risk of thromboembolism?. ### Response: bicuspid aortic valves.


Instruction: No properly designed trial has addressed the optimal therapeutic strategy to prevent ischemic stroke or what other condition?

Output: TIA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No properly designed trial has addressed the optimal therapeutic strategy to prevent ischemic stroke or what other condition?. ### Response: TIA.


Instruction: No spe-cific management recommendations can be made for what conditions?

Output: Libman-Sacks endocarditis,486 age-related calcifications,487 or bicuspid aortic valves487 have been associated with increased risk of thromboembolism, although no properly designed trial has addressed the optimal therapeutic strategy to prevent ischemic stroke or TIA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No spe-cific management recommendations can be made for what conditions?. ### Response: Libman-Sacks endocarditis,486 age-related calcifications,487 or bicuspid aortic valves487 have been associated with increased risk of thromboembolism, although no properly designed trial has addressed the optimal therapeutic strategy to prevent ischemic stroke or TIA.


Instruction: What can be used in patients undergoing bioprosthetic mitral or aortic valve replacement surgery?

Output: oral anticoagulation with warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be used in patients undergoing bioprosthetic mitral or aortic valve replacement surgery?. ### Response: oral anticoagulation with warfarin.


Instruction: What is the target INR for bioprosthetic mitral or aortic valve replacement surgery?

Output: 2.5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the target INR for bioprosthetic mitral or aortic valve replacement surgery?. ### Response: 2.5.


Instruction: How long is oral anticoagulation with warfarin reasonable for?

Output: at least 3 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is oral anticoagulation with warfarin reasonable for?. ### Response: at least 3 months.


Instruction: What is a recommendation based on?

Output: the results of observational studies that have reported an increased risk of ischemic stroke early after surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a recommendation based on?. ### Response: the results of observational studies that have reported an increased risk of ischemic stroke early after surgery.


Instruction: What is the recommended dose of aspirin after 3 to 6 months after surgery?

Output: 75 to 100 mg daily

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommended dose of aspirin after 3 to 6 months after surgery?. ### Response: 75 to 100 mg daily.


Instruction: Patients with a history of ischemic stroke are advised to take what?

Output: aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with a history of ischemic stroke are advised to take what?. ### Response: aspirin.


Instruction: How much antiplatelet therapy is recommended for patients with TIA before the bioprosthetic valve surgery?

Output: 75 to 100 mg daily

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much antiplatelet therapy is recommended for patients with TIA before the bioprosthetic valve surgery?. ### Response: 75 to 100 mg daily.


Instruction: What should patients continue to be managed with after the bioproperty valve insertion?

Output: antiplatelet therapy alone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients continue to be managed with after the bioproperty valve insertion?. ### Response: antiplatelet therapy alone.


Instruction: How should patients with mechanical prosthetic prosthetics be treated?

Output: higher risk of thromboembolic complications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How should patients with mechanical prosthetic prosthetics be treated?. ### Response: higher risk of thromboembolic complications.


Instruction: What does effective antithrombotic therapy require in patients with mechanical prosthetic heart valves?

Output: effective warfarin anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does effective antithrombotic therapy require in patients with mechanical prosthetic heart valves?. ### Response: effective warfarin anticoagulation.


Instruction: What does continuous effective warfarin anticoagulation with an INR in the target range require?

Output: effective antithrombotic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does continuous effective warfarin anticoagulation with an INR in the target range require?. ### Response: effective antithrombotic therapy.


Instruction: How has ACC/AHA guidance been published in separate guidelines?

Output: 33

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How has ACC/AHA guidance been published in separate guidelines?. ### Response: 33.


Instruction: What is the INR of anticoagulation with warfarin?

Output: 2.5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the INR of anticoagulation with warfarin?. ### Response: 2.5.


Instruction: What is recommended for patients with mechanical bileaflet or current-generation single-tilting-disk aortic valve replacement and no risk factors for thromboembolism?

Output: Anticoagulation with warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for patients with mechanical bileaflet or current-generation single-tilting-disk aortic valve replacement and no risk factors for thromboembolism?. ### Response: Anticoagulation with warfarin.


Instruction: What are patients with aortic mechanical prosthesis who have a history of ischemic stroke or TIA at higher risk of?

Output: thromboembolic complications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients with aortic mechanical prosthesis who have a history of ischemic stroke or TIA at higher risk of?. ### Response: thromboembolic complications.


Instruction: What is recommended to maintain the INR at a higher target of 3.0 (range, 2.5–3.5) or to add aspirin 75 to 100 mg daily?

Output: Anticoagulation with warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended to maintain the INR at a higher target of 3.0 (range, 2.5–3.5) or to add aspirin 75 to 100 mg daily?. ### Response: Anticoagulation with warfarin.


Instruction: What is the most frequent and severe extracardiac complications of IE?

Output: Neurological complications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most frequent and severe extracardiac complications of IE?. ### Response: Neurological complications.


Instruction: What is an estimated incidence of up to 20% to 40%?

Output: Neurological complications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an estimated incidence of up to 20% to 40%?. ### Response: Neurological complications.


Instruction: Ischemic cerebrovascular events represent what type of event?

Output: the most com-

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Ischemic cerebrovascular events represent what type of event?. ### Response: the most com-.


Instruction: Meschia et al Guidelines for the Primary Prevention of Stroke 3819 433. Francescone S, Halperin JL. What is the risk of antithrombotic therapy for patients with atrial fibrillation?

Output: Balancing the risks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Meschia et al Guidelines for the Primary Prevention of Stroke 3819 433. Francescone S, Halperin JL. What is the risk of antithrombotic therapy for patients with atrial fibrillation?. ### Response: Balancing the risks.


Instruction: What year did Cardiol. 2008:51:826-827?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Cardiol. 2008:51:826-827?. ### Response: 2008.


Instruction: What is the focus of the expert consensus document?

Output: atrial fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the focus of the expert consensus document?. ### Response: atrial fibrillation.


Instruction: What is the focus of the consensus document on atrial fibrillation?

Output: Antithrombotic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the focus of the consensus document on atrial fibrillation?. ### Response: Antithrombotic therapy.


Instruction: What year did Ann Med. 2008:40:428–436?

Output: 435

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Ann Med. 2008:40:428–436?. ### Response: 435.


Instruction: Who was King SB 3rd, Smith SC Jr, Hirshfeld JW Jr, Jacobs AK, Morrison DA, Feldman TE, Kern MJ, Whitlow PL?

Output: Williams DO

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was King SB 3rd, Smith SC Jr, Hirshfeld JW Jr, Jacobs AK, Morrison DA, Feldman TE, Kern MJ, Whitlow PL?. ### Response: Williams DO.


Instruction: What is the focus of the 2007 Focused update of the ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention?

Output: a report of the American College of Cardiology/American Heart Association Task Force on Practice guide-lines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the focus of the 2007 Focused update of the ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention?. ### Response: a report of the American College of Cardiology/American Heart Association Task Force on Practice guide-lines.


Instruction: What did the American College of Cardiology/American Heart Association Task Force on Practice guide-lines recommend?

Output: Focused update of the ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the American College of Cardiology/American Heart Association Task Force on Practice guide-lines recommend?. ### Response: Focused update of the ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention.


Instruction: What was the name of the group that recommended percutaneous coronary intervention?

Output: American College of Cardiology/American Heart Association Task Force

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the group that recommended percutaneous coronary intervention?. ### Response: American College of Cardiology/American Heart Association Task Force.


Instruction: When was the J Am Coll Cardiol.51:172–209?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol.51:172–209?. ### Response: 2008.


Instruction: Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial?

Output: Lancet. 2009;374:534–542. 437

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial?. ### Response: Lancet. 2009;374:534–542. 437.


Instruction: What is the name of the PROTECT AF trial?

Output: Watchman Left Atrial Appendage System for Embolic Protection in Patients with Atrial Fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the PROTECT AF trial?. ### Response: Watchman Left Atrial Appendage System for Embolic Protection in Patients with Atrial Fibrillation.


Instruction: How long was the follow-up of the ProtECT AAF Trial?

Output: 2.3-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the follow-up of the ProtECT AAF Trial?. ### Response: 2.3-year.


Instruction: What is another name for Watchman Left Atrial Appendage System?

Output: PROTECT AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for Watchman Left Atrial Appendage System?. ### Response: PROTECT AF.


Instruction: Atrial Fibrillation) Trial. Circulation. 2013;127:720–729. 438 What is AFFIRM?

Output: Atrial Fibrillation Follow-up Investigation of Rhythm Management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atrial Fibrillation) Trial. Circulation. 2013;127:720–729. 438 What is AFFIRM?. ### Response: Atrial Fibrillation Follow-up Investigation of Rhythm Management.


Instruction: What is the comparison of rate control and rhythm control in atrial fibrillation patients?

Output: Randomized trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the comparison of rate control and rhythm control in atrial fibrillation patients?. ### Response: Randomized trial.


Instruction: What is the name of the study that investigated the incidence of symptomatic and asymptomatic episodes of atrial fibrillation before and after diagnosis?

Output: Strategies of Treatment of Atrial Fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the incidence of symptomatic and asymptomatic episodes of atrial fibrillation before and after diagnosis?. ### Response: Strategies of Treatment of Atrial Fibrillation.


Instruction: What are the names of the studies that investigated rate control and rhythm control?

Output: Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the studies that investigated rate control and rhythm control?. ### Response: Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) Investigators.


Instruction: What is the term for a prospective, multicenter study of symptomatic and asymptomatic episodes of atrial fibrillation before and after catheter ablation?

Output: DISCERN AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for a prospective, multicenter study of symptomatic and asymptomatic episodes of atrial fibrillation before and after catheter ablation?. ### Response: DISCERN AF.


Instruction: What is STAF?

Output: Strategies of Treatment of Atrial Fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is STAF?. ### Response: Strategies of Treatment of Atrial Fibrillation.


Instruction: What was the name of the STAF study?

Output: Strategies of Treatment of Atrial Fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the STAF study?. ### Response: Strategies of Treatment of Atrial Fibrillation.


Instruction: How did STAF Investigators determine rate control?

Output: Randomized trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did STAF Investigators determine rate control?. ### Response: Randomized trial.


Instruction: What effect does anticoagulation have on cerebral bleeding in stroke patients?

Output: Early recurrence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What effect does anticoagulation have on cerebral bleeding in stroke patients?. ### Response: Early recurrence.


Instruction: What is the name of the RAF Study?

Output: Early recurrence and cerebral bleeding in patients with acute ischemic stroke and atrial fibril-lation: effect of anticoagulation and its timing: the RAF Study. Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the RAF Study?. ### Response: Early recurrence and cerebral bleeding in patients with acute ischemic stroke and atrial fibril-lation: effect of anticoagulation and its timing: the RAF Study. Stroke.


Instruction: When was the RA Study conducted?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the RA Study conducted?. ### Response: 2015.


Instruction: How many strokes were there in 2015?

Output: 2175–2182

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes were there in 2015?. ### Response: 2175–2182.


Instruction: What is CADISS?

Output: cervical artery dissection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CADISS?. ### Response: cervical artery dissection.


Instruction: What is the difference between antiplatelet treatment and anticoagulation treatment for cervical artery dissection?

Output: Antiplatelet treatment compared with anticoagulation treatment for cervical artery dissection (CADISS): a randomised trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between antiplatelet treatment and anticoagulation treatment for cervical artery dissection?. ### Response: Antiplatelet treatment compared with anticoagulation treatment for cervical artery dissection (CADISS): a randomised trial.


Instruction: What are the results of CADISS and a systematic review of?

Output: Prognosis of carotid dissecting aneurysms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of CADISS and a systematic review of?. ### Response: Prognosis of carotid dissecting aneurysms.


Instruction: What is the name of the systematic review?

Output: Neurology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review?. ### Response: Neurology.


Instruction: When was this article published?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this article published?. ### Response: April 28, 2023.


Instruction: What is clinical stability defined by?

Output: the absence of low output, hypotension, persistent tachycardia, apparent shock, high-grade ventricular or symptomatic supraventricular tachyarrhythmias, and spontaneous recurrent ischemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is clinical stability defined by?. ### Response: the absence of low output, hypotension, persistent tachycardia, apparent shock, high-grade ventricular or symptomatic supraventricular tachyarrhythmias, and spontaneous recurrent ischemia.


Instruction: What indicates Class of Recommendation; HF, heart failure; LOE, Level of Evidence; MI, myocardial infarction; PCI, percutaneous coronary intervention?

Output: COR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates Class of Recommendation; HF, heart failure; LOE, Level of Evidence; MI, myocardial infarction; PCI, percutaneous coronary intervention?. ### Response: COR.


Instruction: What is MI?

Output: myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is MI?. ### Response: myocardial infarction.


Instruction: What is PCI?

Output: percutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PCI?. ### Response: percutaneous coronary intervention.


Instruction: When was Evidence downloaded from http://ahajournals.org?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Evidence downloaded from http://ahajournals.org?. ### Response: April 28, 2023.


Instruction: What is the 2017 High Blood Pressure Clinical Practice Guideline e99events among persons without hypertension?

Output: a meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2017 High Blood Pressure Clinical Practice Guideline e99events among persons without hypertension?. ### Response: a meta-analysis.


Instruction: When was the JAMA 305:913-22?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the JAMA 305:913-22?. ### Response: 2011.


Instruction: What was the outcome among hypertensive patients with concomitant peripheral and coronary artery dis-ease?

Output: Outcomes among hyperten-sive patients with concomitant peripheral and coronary artery dis-ease: findings from the INternational VErapamil-SR/Trandolapril STudy. Hypertension. 2010;55:48–53. S9.5-4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome among hypertensive patients with concomitant peripheral and coronary artery dis-ease?. ### Response: Outcomes among hyperten-sive patients with concomitant peripheral and coronary artery dis-ease: findings from the INternational VErapamil-SR/Trandolapril STudy. Hypertension. 2010;55:48–53. S9.5-4.


Instruction: What did the INternational VErapamil-SR/Trandolapril STudy study find?

Output: Outcomes among hyperten-sive patients with concomitant peripheral and coronary artery dis-ease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the INternational VErapamil-SR/Trandolapril STudy study find?. ### Response: Outcomes among hyperten-sive patients with concomitant peripheral and coronary artery dis-ease.


Instruction: What was the outcome of the V ALUE trial?

Output: Outcomes in subgroups of hypertensive patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome of the V ALUE trial?. ### Response: Outcomes in subgroups of hypertensive patients.


Instruction: What is the name of the ALUE trial?

Output: V ALUE trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the ALUE trial?. ### Response: V ALUE trial.


Instruction: What type of diabetes does Emdin CA, Rahimi K and Neal B have?

Output: type 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diabetes does Emdin CA, Rahimi K and Neal B have?. ### Response: type 2.


Instruction: What is the name of the systematic review and meta-analysis of blood pressure lowering in type 2 diabetes?

Output: Lancet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta-analysis of blood pressure lowering in type 2 diabetes?. ### Response: Lancet.


Instruction: When did the Cochrane Database Syst Rev. 2013:10:CD008277.

Output: S9.6-3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Cochrane Database Syst Rev. 2013:10:CD008277.. ### Response: S9.6-3.


Instruction: S9.6-3. Cushman WC, Evans GW, Byington RP, et al. Effects of inten-sive blood-pressure control in type 2 diabetes mellitus. ACCORD Study. 2010;362:1575–85.

Output: Cochrane Database Syst Rev. 2013;10:CD008277

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: S9.6-3. Cushman WC, Evans GW, Byington RP, et al. Effects of inten-sive blood-pressure control in type 2 diabetes mellitus. ACCORD Study. 2010;362:1575–85.. ### Response: Cochrane Database Syst Rev. 2013;10:CD008277.


Instruction: What is the effect of lowering on cardiovascular and renal outcomes?

Output: Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of lowering on cardiovascular and renal outcomes?. ### Response: Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis.


Instruction: What was the ACCORD randomized trial?

Output: Outcomes of combined cardiovascular risk factor management strategies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the ACCORD randomized trial?. ### Response: Outcomes of combined cardiovascular risk factor management strategies.


Instruction: What is the effect of intensive blood pressure lowering on left ventricular hypertrophy in patients with diabetes mellitus?

Output: Action to Control Cardiovascular Risk in Diabetes Blood Pressure Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of intensive blood pressure lowering on left ventricular hypertrophy in patients with diabetes mellitus?. ### Response: Action to Control Cardiovascular Risk in Diabetes Blood Pressure Trial.


Instruction: What are the results of the Action to Control Cardiovascular Risk in Diabetes Blood Pressure Trial?

Output: S9.6-7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of the Action to Control Cardiovascular Risk in Diabetes Blood Pressure Trial?. ### Response: S9.6-7.


Instruction: What is the effect of intensive blood pres-sure lowering on the progression of chronic kidney disease?

Output: a sys-tematic review and meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of intensive blood pres-sure lowering on the progression of chronic kidney disease?. ### Response: a sys-tematic review and meta-analysis.


Instruction: When did the CMAJ issue 185:949-57?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the CMAJ issue 185:949-57?. ### Response: 2013.


Instruction: What did Bress AP, King JB, Kreider KE, et al. do?

Output: Effect of intensive versus standard blood pressure treatment according to baseline prediabe-tes status: a post hoc analysis of a randomized trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Bress AP, King JB, Kreider KE, et al. do?. ### Response: Effect of intensive versus standard blood pressure treatment according to baseline prediabe-tes status: a post hoc analysis of a randomized trial.


Instruction: What is the difference between standard blood pressure treatment and prediabetes status?

Output: Effect of intensive

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between standard blood pressure treatment and prediabetes status?. ### Response: Effect of intensive.


Instruction: What is a post hoc analysis of a randomized trial?

Output: Effect of intensive versus standard blood pressure treatment according to baseline prediabe-tes status

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a post hoc analysis of a randomized trial?. ### Response: Effect of intensive versus standard blood pressure treatment according to baseline prediabe-tes status.


Instruction: Diabetes Care. 2017;40:1401–8. S9.6-9.

Output: Effects of different blood pressure-lowering regimens

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Diabetes Care. 2017;40:1401–8. S9.6-9.. ### Response: Effects of different blood pressure-lowering regimens.


Instruction: What are the results of prospec-tively designed overviews of randomized trials in individuals with and without diabetes mellitus?

Output: Effects of different blood pressure-lowering regimens on major cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of prospec-tively designed overviews of randomized trials in individuals with and without diabetes mellitus?. ### Response: Effects of different blood pressure-lowering regimens on major cardiovascular events.


Instruction: What is the Arch Intern Med 2005;165:1410–9. S9.6-10?

Output: Effects of different blood pressure-lowering regimens on major cardiovascular events in individuals with and without diabetes mellitus: results of prospec-tively designed overviews of randomized trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Arch Intern Med 2005;165:1410–9. S9.6-10?. ### Response: Effects of different blood pressure-lowering regimens on major cardiovascular events in individuals with and without diabetes mellitus: results of prospec-tively designed overviews of randomized trials.


Instruction: How does antihypertensive treatment help prevent heart disease?

Output: Clinical outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does antihypertensive treatment help prevent heart disease?. ### Response: Clinical outcomes.


Instruction: What is the name of the antihypertensive and lipid-lowering treatment to prevent heart attack trial?

Output: Antihypertensive

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the antihypertensive and lipid-lowering treatment to prevent heart attack trial?. ### Response: Antihypertensive.


Instruction: What does concentration and normoglycemia do?

Output: impaired fast-ing glucose concentration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does concentration and normoglycemia do?. ### Response: impaired fast-ing glucose concentration.


Instruction: What is the relationship between changes in proteolytic determinants of matrix composition and structur -al, functional, and clinical manifestations of hypertensive heart disease?

Output: Matrix metallopro-teinases/tissue inhibitors of metalloproteinases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the relationship between changes in proteolytic determinants of matrix composition and structur -al, functional, and clinical manifestations of hypertensive heart disease?. ### Response: Matrix metallopro-teinases/tissue inhibitors of metalloproteinases.


Instruction: Circulation. 2006;113:2089–2096. 228

Output: Matrix metallopro-teinases/tissue inhibitors of metalloproteinases: relationship between changes in proteolytic determinants of matrix composition and structur -al, functional, and clinical manifestations of hypertensive heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation. 2006;113:2089–2096. 228. ### Response: Matrix metallopro-teinases/tissue inhibitors of metalloproteinases: relationship between changes in proteolytic determinants of matrix composition and structur -al, functional, and clinical manifestations of hypertensive heart disease.


Instruction: What is the transition from chronic compensated to acute decompen-sated heart failure?

Output: pathophysiological insights obtained from continuous monitoring of intracardiac pressures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the transition from chronic compensated to acute decompen-sated heart failure?. ### Response: pathophysiological insights obtained from continuous monitoring of intracardiac pressures.


Instruction: What are the pathophysiological insights obtained from continuous monitoring of intracardiac pressures?

Output: Transition from chronic compensated to acute decompen-sated heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the pathophysiological insights obtained from continuous monitoring of intracardiac pressures?. ### Response: Transition from chronic compensated to acute decompen-sated heart failure.


Instruction: What is the role of atrial remodeling/dysfunction in cardiac features of heart failure?

Output: preserved ejection fraction versus nonfailing hypertensive left ven-tricular hypertrophy in the urban Baltimore community

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of atrial remodeling/dysfunction in cardiac features of heart failure?. ### Response: preserved ejection fraction versus nonfailing hypertensive left ven-tricular hypertrophy in the urban Baltimore community.


Instruction: What type of hypertensive left ven-tricular hypertrophy is more common in Baltimore?

Output: nonfailing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of hypertensive left ven-tricular hypertrophy is more common in Baltimore?. ### Response: nonfailing.


Instruction: What is the role of atrial remodeling/dysfunction in urban Baltimore community?

Output: Cardiovascular features of heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of atrial remodeling/dysfunction in urban Baltimore community?. ### Response: Cardiovascular features of heart failure.


Instruction: What are the names of the people with heart failure and preserved ejection fraction from Olmsted County, Minnesota?

Output: Lam CS, Roger VL, Rodeheffer RJ, Bursi F, Borlaug BA, Ommen SR, Kass DA, Redfield MM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the people with heart failure and preserved ejection fraction from Olmsted County, Minnesota?. ### Response: Lam CS, Roger VL, Rodeheffer RJ, Bursi F, Borlaug BA, Ommen SR, Kass DA, Redfield MM.


Instruction: Where is the preserved ejection fraction from?

Output: Olmsted County, Minnesota

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the preserved ejection fraction from?. ### Response: Olmsted County, Minnesota.


Instruction: What is the Circulation. 2007:115:1982-1990?

Output: Cardiac structure and ventricular-vascular func-tion in persons with heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Circulation. 2007:115:1982-1990?. ### Response: Cardiac structure and ventricular-vascular func-tion in persons with heart failure.


Instruction: Who is the Borlaug BA, Lam CS, Rodeheffer RJ, Redfield MM?

Output: Ommen SR, Kass DA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Borlaug BA, Lam CS, Rodeheffer RJ, Redfield MM?. ### Response: Ommen SR, Kass DA.


Instruction: What does flash pulmonary edema have to do with hypertension and reoccurrence of coronary revas-cularization?

Output: association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does flash pulmonary edema have to do with hypertension and reoccurrence of coronary revas-cularization?. ### Response: association.


Instruction: What is the name of the journal that studies the prognostic factors of acute pulmonary embolism?

Output: Am J Med.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies the prognostic factors of acute pulmonary embolism?. ### Response: Am J Med..


Instruction: What are the prognostic factors in acute pulmonary edema?

Output: ischemic heart disease without accompanying myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the prognostic factors in acute pulmonary edema?. ### Response: ischemic heart disease without accompanying myocardial infarction.


Instruction: What is the cause of ischemic heart disease without accompanying myocardial infarction?

Output: Acute pulmonary edema

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cause of ischemic heart disease without accompanying myocardial infarction?. ### Response: Acute pulmonary edema.


Instruction: What is the paradox of the stiff heart?

Output: Pulmonary edema in coronary-artery disease without cardiomegaly

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the paradox of the stiff heart?. ### Response: Pulmonary edema in coronary-artery disease without cardiomegaly.


Instruction: What is Chin MH, Goldman L. Correlates of major complications or death in patients admitted to hospital with congestive heart failure?

Output: 237

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Chin MH, Goldman L. Correlates of major complications or death in patients admitted to hospital with congestive heart failure?. ### Response: 237.


Instruction: How does low dose dobutamine echocar-diography predict improvement in functional capacity after exercise training in patients?

Output: ischemic cardiomyopathy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does low dose dobutamine echocar-diography predict improvement in functional capacity after exercise training in patients?. ### Response: ischemic cardiomyopathy.


Instruction: What is the name of the hospital with congestive heart failure?

Output: Arch Intern

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the hospital with congestive heart failure?. ### Response: Arch Intern.


Instruction: What predicts improvement in functional capacity after exercise training in patients with ischemic cardiomyopathy?

Output: Low dose dobutamine echocar -diography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What predicts improvement in functional capacity after exercise training in patients with ischemic cardiomyopathy?. ### Response: Low dose dobutamine echocar -diography.


Instruction: When did J Am Coll Cardiol.31:1027-1034?

Output: 1998

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J Am Coll Cardiol.31:1027-1034?. ### Response: 1998.


Instruction: What is GLORIA-AF?

Output: Fibrillation (GLORIA-AF) Phase I cohort

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is GLORIA-AF?. ### Response: Fibrillation (GLORIA-AF) Phase I cohort.


Instruction: What is the CHA2DS2-VASc score used for?

Output: re ﬁning stroke risk strati ﬁcation in ’low-risk ’Asian patientswith atrial ﬁbrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the CHA2DS2-VASc score used for?. ### Response: re ﬁning stroke risk strati ﬁcation in ’low-risk ’Asian patientswith atrial ﬁbrillation.


Instruction: How many Chinese had atrial fibrillation in Hong Kong?

Output: 9727

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many Chinese had atrial fibrillation in Hong Kong?. ### Response: 9727.


Instruction: What is the risk of stroke and intracranialhemorrhage in 9727 Chinese?

Output: Risk of stroke and intracranialhemorrhage in 9727 Chinese with atrial ﬁbrillation in Hong Kong

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of stroke and intracranialhemorrhage in 9727 Chinese?. ### Response: Risk of stroke and intracranialhemorrhage in 9727 Chinese with atrial ﬁbrillation in Hong Kong.


Instruction: Where did Lip GY, Lam KF, Tse HF live?

Output: Hong Kong

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where did Lip GY, Lam KF, Tse HF live?. ### Response: Hong Kong.


Instruction: In what year was EurHeart J26(22):2422-2434?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was EurHeart J26(22):2422-2434?. ### Response: 2005.


Instruction: What was the name of the 2005 study?

Output: EurHeart J

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the 2005 study?. ### Response: EurHeart J.


Instruction: What did Le Heuzey JY, Breithardt G, Camm J, et al. do for atrial fibrillation?

Output: ﬁcationschemes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Le Heuzey JY, Breithardt G, Camm J, et al. do for atrial fibrillation?. ### Response: ﬁcationschemes.


Instruction: When was the Am J Cardiol 105(5) published?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Am J Cardiol 105(5) published?. ### Response: 2010.


Instruction: What does ORBIT-AF stand for?

Output: Outcomes Registry for Better InformedTreatment of Atrial Fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ORBIT-AF stand for?. ### Response: Outcomes Registry for Better InformedTreatment of Atrial Fibrillation.


Instruction: What is the name of the registry for better informed treatment of atrial fibrillation?

Output: Outcomes Registry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the registry for better informed treatment of atrial fibrillation?. ### Response: Outcomes Registry.


Instruction: What is the EURObservationalResearch Programme Atrial Fibrillation (EORP-AF) Pilot GeneralRegistry?

Output: A prospective survey inEuropean Society of Cardiology member countries of atrialﬁbrillation management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the EURObservationalResearch Programme Atrial Fibrillation (EORP-AF) Pilot GeneralRegistry?. ### Response: A prospective survey inEuropean Society of Cardiology member countries of atrialﬁbrillation management.


Instruction: How many European countries did the 2010 ESC Guidelines on atrial fibrillation publish?

Output: seven

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many European countries did the 2010 ESC Guidelines on atrial fibrillation publish?. ### Response: seven.


Instruction: Who published the 2010 ESC Guidelines on atrial fibrillation?

Output: Kirchhof P, Ammentorp B, Darius H, et al. Management of atrialﬁbrillation in seven European countries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2010 ESC Guidelines on atrial fibrillation?. ### Response: Kirchhof P, Ammentorp B, Darius H, et al. Management of atrialﬁbrillation in seven European countries.


Instruction: What is the European Registry inAtrial Fibrillation (PREFER in AF) called?

Output: GLORIA-AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the European Registry inAtrial Fibrillation (PREFER in AF) called?. ### Response: GLORIA-AF.


Instruction: How many pages were in Europace in 2014?

Output: 6-14

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many pages were in Europace in 2014?. ### Response: 6-14.


Instruction: Who is the author of SPRINT-AF?

Output: Ha AC, Singh N, Cox JL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of SPRINT-AF?. ### Response: Ha AC, Singh N, Cox JL.


Instruction: What is the acronym for Stroke Prevention and RhythmInterventions in Atrial Fibrillation?

Output: SPRINT-AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Stroke Prevention and RhythmInterventions in Atrial Fibrillation?. ### Response: SPRINT-AF.


Instruction: What is SPRINT-AF?

Output: Oral anticoagulation for strokeprevention in Canadian practice: Stroke Prevention and RhythmInterventions in Atrial Fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SPRINT-AF?. ### Response: Oral anticoagulation for strokeprevention in Canadian practice: Stroke Prevention and RhythmInterventions in Atrial Fibrillation.


Instruction: When did Circ Cardiovasc Qual Outcomes release?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circ Cardiovasc Qual Outcomes release?. ### Response: 2011.


Instruction: What are the 2016 guidelines of the Taiwan Heart Rhythm Society and the Taiwan Society of Cardiology for the management of atrial fibrillation?

Output: 2016 Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the 2016 guidelines of the Taiwan Heart Rhythm Society and the Taiwan Society of Cardiology for the management of atrial fibrillation?. ### Response: 2016 Guidelines.


Instruction: What is the name of the study that evaluated risk strati ficationschemes for ischaemic heart disease?

Output: Swedish Atrial Fibrillation cohort study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated risk strati ficationschemes for ischaemic heart disease?. ### Response: Swedish Atrial Fibrillation cohort study.


Instruction: What is the Swedish Atrial Fibrillation cohort study?

Output: Evaluation of risk strati ﬁcationschemes for ischaemic stroke and bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Swedish Atrial Fibrillation cohort study?. ### Response: Evaluation of risk strati ﬁcationschemes for ischaemic stroke and bleeding.


Instruction: What are the differences between atrialflutter and atrial fibrillation in a general population?

Output: comorbidities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the differences between atrialflutter and atrial fibrillation in a general population?. ### Response: comorbidities.


Instruction: What are the comorbidities associated with fibrillation in a general population?

Output: differencesin comorbidities associated with their respective onset

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the comorbidities associated with fibrillation in a general population?. ### Response: differencesin comorbidities associated with their respective onset.


Instruction: What is the name of the study that looked at lone atrial fibrosis?

Output: RecordAF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that looked at lone atrial fibrosis?. ### Response: RecordAF.


Instruction: What year did NICE publish a review of the clinical record?

Output: 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did NICE publish a review of the clinical record?. ### Response: 2018.


Instruction: What is the subject of NICE 2018?

Output: Chronic Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the subject of NICE 2018?. ### Response: Chronic Heart Failure.


Instruction: Where are patients being managed in primary care?

Output: the patient’s GP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are patients being managed in primary care?. ### Response: the patient’s GP.


Instruction: What could be useful added in to existing appointments?

Output: the HF review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could be useful added in to existing appointments?. ### Response: the HF review.


Instruction: What did the committee agree should be a priority?

Output: coordination between services

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee agree should be a priority?. ### Response: coordination between services.


Instruction: What was already advocated in the multimorbidity guideline?

Output: a single care coordinator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was already advocated in the multimorbidity guideline?. ### Response: a single care coordinator.


Instruction: How would a single care coordinator be helpful in HF?

Output: multimorbidity guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How would a single care coordinator be helpful in HF?. ### Response: multimorbidity guideline.


Instruction: Who was the named healthcare coordinator in HF?

Output: the HF specialist nurse

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the named healthcare coordinator in HF?. ### Response: the HF specialist nurse.


Instruction: What was the name of the HF specialist nurse?

Output: healthcare coordinator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the HF specialist nurse?. ### Response: healthcare coordinator.


Instruction: Where was a person being actively managed?

Output: multidisciplinary specialist HF team

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where was a person being actively managed?. ### Response: multidisciplinary specialist HF team.


Instruction: Where would routine management in primary care usually change to the patient's GP?

Output: where the patient was in the HF pathway

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where would routine management in primary care usually change to the patient's GP?. ### Response: where the patient was in the HF pathway.


Instruction: Members advocated collaborative working between primary and secondary care through what?

Output: the MDT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Members advocated collaborative working between primary and secondary care through what?. ### Response: the MDT.


Instruction: What should be an essential part of a care plan?

Output: future plans

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be an essential part of a care plan?. ### Response: future plans.


Instruction: What did the committee feel was important?

Output: coordination between services

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee feel was important?. ### Response: coordination between services.


Instruction: What did the committee feel was important for patients to have access to?

Output: their health information

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee feel was important for patients to have access to?. ### Response: their health information.


Instruction: What was a suggestion that patients could hold their heart failure notes?

Output: The committee felt that it was important that patients have access to their health information, for their own reference, and also to inform others. There was a suggestion that patients could hold their heart failure notes, bu t it was felt that this was not yet practical

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a suggestion that patients could hold their heart failure notes?. ### Response: The committee felt that it was important that patients have access to their health information, for their own reference, and also to inform others. There was a suggestion that patients could hold their heart failure notes, bu t it was felt that this was not yet practical.


Instruction: What should a person receive after every formal review of their care plan?

Output: a copy of everything that is sent about them

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should a person receive after every formal review of their care plan?. ### Response: a copy of everything that is sent about them.


Instruction: What was felt was not practical?

Output: hold their heart failure notes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was felt was not practical?. ### Response: hold their heart failure notes.


Instruction: What did the committee try to define in the summary of the patients status and how the care plan would be formulated?

Output: what would be included

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee try to define in the summary of the patients status and how the care plan would be formulated?. ### Response: what would be included.


Instruction: The committee appreciated that this would vary depending on what?

Output: where the patient was in the HF pathway

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committee appreciated that this would vary depending on what?. ### Response: where the patient was in the HF pathway.


Instruction: Where was the patient in the HF pathway?

Output: multidisciplinary specialist HF team, but at the poi nt of transfer to routine management in primary care, this would usually change to the patient’s GP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where was the patient in the HF pathway?. ### Response: multidisciplinary specialist HF team, but at the poi nt of transfer to routine management in primary care, this would usually change to the patient’s GP.


Instruction: What did the committee agree that it is essential that the patient is given a named contact and knows?

Output: who is going to follow them up and when

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee agree that it is essential that the patient is given a named contact and knows?. ### Response: who is going to follow them up and when.


Instruction: What were the most important things to include after contact details and follow-up arrangements?

Output: the diagnosis, current treatment, red flag signs that HF is deteriorating, and signposting to further information / sources of support

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the most important things to include after contact details and follow-up arrangements?. ### Response: the diagnosis, current treatment, red flag signs that HF is deteriorating, and signposting to further information / sources of support.


Instruction: What were red flag signs that HF is deteriorating and signposting to?

Output: further information / sources of support

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were red flag signs that HF is deteriorating and signposting to?. ### Response: further information / sources of support.


Instruction: Where appropriate, the care plan would include aetiology of HF, social circumstances, carer needs, how they can access rehabilitation and other resources?

Output: Even where patients are being routinely seen in the MDT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where appropriate, the care plan would include aetiology of HF, social circumstances, carer needs, how they can access rehabilitation and other resources?. ### Response: Even where patients are being routinely seen in the MDT.


Instruction: The committee acknowledged that the full summary of status and care plan may not be ready to provide what to the patient during their treatment?

Output: heart failure notes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committee acknowledged that the full summary of status and care plan may not be ready to provide what to the patient during their treatment?. ### Response: heart failure notes.


Instruction: What is the DASH diet high in?

Output: potassium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the DASH diet high in?. ### Response: potassium.


Instruction: What is a BP-lowering effect of increased physical activity?

Output: dynamic aerobic exercise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a BP-lowering effect of increased physical activity?. ### Response: dynamic aerobic exercise.


Instruction: What isometric exercise has been an intrinsic compo-nent of longer-term?

Output: increased physical activity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What isometric exercise has been an intrinsic compo-nent of longer-term?. ### Response: increased physical activity.


Instruction: What are the average reductions in SBP with aerobic exercise in adult patients with normotension?

Output: 2 to 4 mm Hg and 5 to 8 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the average reductions in SBP with aerobic exercise in adult patients with normotension?. ### Response: 2 to 4 mm Hg and 5 to 8 mm Hg.


Instruction: What has been an intrinsic compo-nent of longer-term weight reduction interventions used to reduce BP and prevent hypertension?

Output: increased physical activity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been an intrinsic compo-nent of longer-term weight reduction interventions used to reduce BP and prevent hypertension?. ### Response: increased physical activity.


Instruction: What have been reported with lower- and higher-intensity exercise and with continuous and in-terval exercise training?

Output: BP-lowering effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have been reported with lower- and higher-intensity exercise and with continuous and in-terval exercise training?. ### Response: BP-lowering effects.


Instruction: Meta-analyses sug-gest what exercise results in substantial lowering of BP?

Output: isometric

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Meta-analyses sug-gest what exercise results in substantial lowering of BP?. ### Response: isometric.


Instruction: Exercise results in substantial lowering of what?

Output: BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Exercise results in substantial lowering of what?. ### Response: BP.


Instruction: In observational studies, there is a strong, predictable di-rect relationship between alcohol consumption and BP.

Output: S6.2-18,S6.2-19,S6.2-316

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In observational studies, there is a strong, predictable di-rect relationship between alcohol consumption and BP.. ### Response: S6.2-18,S6.2-19,S6.2-316.


Instruction: What is the name of the study conducted by the Society of Actuaries?

Output: Build and Blood Pressure Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study conducted by the Society of Actuaries?. ### Response: Build and Blood Pressure Study.


Instruction: When was the Build and Blood Pressure Study conducted?

Output: 1959

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Build and Blood Pressure Study conducted?. ### Response: 1959.


Instruction: Where was the Framingham Study published?

Output: Harvard University Press

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where was the Framingham Study published?. ### Response: Harvard University Press.


Instruction: What was the title of Dawber TR's study?

Output: The Framingham Study: The Epidemiology of Atherosclerotic Disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the title of Dawber TR's study?. ### Response: The Framingham Study: The Epidemiology of Atherosclerotic Disease.


Instruction: What is Atherosclerotic Disease?

Output: The Epidemiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Atherosclerotic Disease?. ### Response: The Epidemiology.


Instruction: What is the average diastolic blood pressure in patients with hypertension?

Output: 90 through 114 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the average diastolic blood pressure in patients with hypertension?. ### Response: 90 through 114 mm Hg.


Instruction: When did JAMA issue 202?

Output: 1967

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did JAMA issue 202?. ### Response: 1967.


Instruction: How many mm Hg are there in patients who were treated for hypertension in 1967?

Output: 129

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mm Hg are there in patients who were treated for hypertension in 1967?. ### Response: 129.


Instruction: What is the average diastolic blood pressure in patients?

Output: 90 through 114 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the average diastolic blood pressure in patients?. ### Response: 90 through 114 mm Hg.


Instruction: What is a remarkable success story in the treatment of hypertension?

Output: The treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a remarkable success story in the treatment of hypertension?. ### Response: The treatment.


Instruction: What is the name of the organization that coordinates the National High Blood Pressure Education Program?

Output: National High Blood Pressure Education Program Coordinating Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that coordinates the National High Blood Pressure Education Program?. ### Response: National High Blood Pressure Education Program Coordinating Committee.