Instruction: What type of device are implantable cardioverter-defibrillators used in?

Output: dialysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of device are implantable cardioverter-defibrillators used in?. ### Response: dialysis.


Instruction: What is a mechanism of sudden cardiac death in patients with chronic kidney disease?

Output: Bradycardia and asystole

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a mechanism of sudden cardiac death in patients with chronic kidney disease?. ### Response: Bradycardia and asystole.


Instruction: What is the 2017 AHA/ACC/HRS guideline for?

Output: management of patients with ventricular arrhythmias and the prevention of sudden cardiac death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2017 AHA/ACC/HRS guideline for?. ### Response: management of patients with ventricular arrhythmias and the prevention of sudden cardiac death.


Instruction: What does the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society do?

Output: Systematic review for the 2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society do?. ### Response: Systematic review for the 2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death.


Instruction: What is the primary prevention implantable cardioverter defibrillators in end stage kidney dis-ease patients on dialysis?

Output: sudden cardiac death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary prevention implantable cardioverter defibrillators in end stage kidney dis-ease patients on dialysis?. ### Response: sudden cardiac death.


Instruction: What are implantable cardioverter defibrillators used for in end-stage kidney dis-ease patients on dialysis?

Output: Primary prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are implantable cardioverter defibrillators used for in end-stage kidney dis-ease patients on dialysis?. ### Response: Primary prevention.


Instruction: What is the 2014 AHA/ACC guideline for the management of patients with valvular heart disease?

Output: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2014 AHA/ACC guideline for the management of patients with valvular heart disease?. ### Response: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.


Instruction: What did the American College of Cardiology/American Heart Association Task Force on Practice Guidelines do?

Output: a report

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the American College of Cardiology/American Heart Association Task Force on Practice Guidelines do?. ### Response: a report.


Instruction: What is the name of the group that compiled a report on heart disease?

Output: American College of Cardiology/American Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that compiled a report on heart disease?. ### Response: American College of Cardiology/American Heart Association Task Force on Practice Guidelines.


Instruction: When did Circulation. 2014 issue 129:e521–643?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circulation. 2014 issue 129:e521–643?. ### Response: 2014.


Instruction: How did the Task Force report on practice guidelines affect patients with asymptomatic severe aortic stenosis?

Output: Natural history, diagnostic approaches, and therapeutic strategies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did the Task Force report on practice guidelines affect patients with asymptomatic severe aortic stenosis?. ### Response: Natural history, diagnostic approaches, and therapeutic strategies.


Instruction: What is severe aortic stenosis?

Output: asymptom-atic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is severe aortic stenosis?. ### Response: asymptom-atic.


Instruction: What is asymptomatic mitral valve prolapse in the community?

Output: Natural history

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is asymptomatic mitral valve prolapse in the community?. ### Response: Natural history.


Instruction: How is sudden death in mitral regurgitation caused?

Output: flail leaflet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is sudden death in mitral regurgitation caused?. ### Response: flail leaflet.


Instruction: What is the cause of death in mitral regurgitation?

Output: flail leaflet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cause of death in mitral regurgitation?. ### Response: flail leaflet.


Instruction: What is a risk of ventricular dysrhythmias and death?

Output: ileaflet mitral valve pro-lapse

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk of ventricular dysrhythmias and death?. ### Response: ileaflet mitral valve pro-lapse.


Instruction: When was the J Am Coll Cardiol.34:2078-85?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol.34:2078-85?. ### Response: 1999.


Instruction: What is the name of the disease that causes sudden cardiac death?

Output: chronic kidney disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease that causes sudden cardiac death?. ### Response: chronic kidney disease.


Instruction: How many patients with cardiac arrest have malignant bileaflet mitral valve prolapse syndrome?

Output: S10.6-8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with cardiac arrest have malignant bileaflet mitral valve prolapse syndrome?. ### Response: S10.6-8.


Instruction: When did the J Am Coll Cardiol 2012 issue 62:222-30?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the J Am Coll Cardiol 2012 issue 62:222-30?. ### Response: 2013.


Instruction: What year did Am Coll Cardiol. 2012:62:222-30?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Am Coll Cardiol. 2012:62:222-30?. ### Response: 2015.


Instruction: What is the name of the prospective study of sud-den cardiac death among women in the United States?

Output: Circulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective study of sud-den cardiac death among women in the United States?. ### Response: Circulation.


Instruction: Which year did Circulation. 2003:107:2096-101?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which year did Circulation. 2003:107:2096-101?. ### Response: 2015.


Instruction: Who is the author of Sudden coronary death in women?

Output: Kannel WB, Wilson PW, D’Agostino RB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of Sudden coronary death in women?. ### Response: Kannel WB, Wilson PW, D’Agostino RB.


Instruction: What is the lifetime risk for sudden cardiac arrest?

Output: S10.6-10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the lifetime risk for sudden cardiac arrest?. ### Response: S10.6-10.


Instruction: What is a woman's risk for heart failure?

Output: Sudden coronary death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a woman's risk for heart failure?. ### Response: Sudden coronary death.


Instruction: When was Am Heart J.136:205-12?

Output: 1998

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Am Heart J.136:205-12?. ### Response: 1998.


Instruction: What is the name of the book that treats heart failure chronic heart failure?

Output: NICE 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the book that treats heart failure chronic heart failure?. ### Response: NICE 2018.


Instruction: Who is the author of NICE 2018?

Output: 978

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of NICE 2018?. ### Response: 978.


Instruction: What does GRADE stand for?

Output: Quality of the evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does GRADE stand for?. ### Response: Quality of the evidence.


Instruction: What is the CI for relative effect?

Output: 95%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the CI for relative effect?. ### Response: 95%.


Instruction: How is risk with placebo calculated?

Output: Risk difference with Mineralocorticoid receptor antagonist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is risk with placebo calculated?. ### Response: Risk difference with Mineralocorticoid receptor antagonist.


Instruction: What is the 95% CI for all-cause mortality?

Output: Relative effect  (95% CI)  Anticipated absolute effects  Risk with Placebo  Risk difference with Mineralocorticoid receptor antagonist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 95% CI for all-cause mortality?. ### Response: Relative effect  (95% CI)  Anticipated absolute effects  Risk with Placebo  Risk difference with Mineralocorticoid receptor antagonist.


Instruction: How many studies did MODERATEa due to imprecision?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies did MODERATEa due to imprecision?. ### Response: 1.


Instruction: What was the time to event?

Output: 3.3 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the time to event?. ### Response: 3.3 years.


Instruction: How many studies were conducted?

Output: 400

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were conducted?. ### Response: 400.


Instruction: What is the term for all-cause mortality?

Output: dichotomous

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for all-cause mortality?. ### Response: dichotomous.


Instruction: Why is the Peto Odds Ratio 7.07?

Output: risk of bias, imprecision

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is the Peto Odds Ratio 7.07?. ### Response: risk of bias, imprecision.


Instruction: How many studies were conducted in Kansas City?

Output: 2902

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were conducted in Kansas City?. ### Response: 2902.


Instruction: Why was the risk of bias a factor in the study?

Output: imprecision

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the risk of bias a factor in the study?. ### Response: imprecision.


Instruction: What is the mean quality of life in Kansas city?

Output: 1.35 higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the mean quality of life in Kansas city?. ### Response: 1.35 higher.


Instruction: How much higher was the mean quality of life in the intervention groups?

Output: 1.35

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much higher was the mean quality of life in the intervention groups?. ### Response: 1.35.


Instruction: What is the EQ-VAS?

Output: mean quality of life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the EQ-VAS?. ### Response: mean quality of life.


Instruction: Why was time unclear?

Output: risk of bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was time unclear?. ### Response: risk of bias.


Instruction: What is the risk of bias?

Output: LOWc

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of bias?. ### Response: LOWc.


Instruction: What was the mean quality of life in the intervention group?

Output: 1.35 higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean quality of life in the intervention group?. ### Response: 1.35 higher.


Instruction: How much higher was the average of the two groups?

Output: 1.35

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much higher was the average of the two groups?. ### Response: 1.35.


Instruction: Which is the scale from 0 to 105?

Output: Quality of life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which is the scale from 0 to 105?. ### Response: Quality of life.


Instruction: How long did MODERATEc due to risk of bias?

Output: 1 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did MODERATEc due to risk of bias?. ### Response: 1 years.


Instruction: What was the mean quality of life (minnesota) in the control groups?

Output: 21

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean quality of life (minnesota) in the control groups?. ### Response: 21.


Instruction: What is the SF-36 Physical Functioning scale 400?

Output: 1 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the SF-36 Physical Functioning scale 400?. ### Response: 1 years.


Instruction: Why is MODERATEc due to risk of bias?

Output: The mean quality of life (minnesota) in the control groups

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is MODERATEc due to risk of bias?. ### Response: The mean quality of life (minnesota) in the control groups.


Instruction: What was the mean quality of life in the intervention groups?

Output: 1.35 higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean quality of life in the intervention groups?. ### Response: 1.35 higher.


Instruction: How much lower was the mean quality of life in the control groups?

Output: 21

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much lower was the mean quality of life in the control groups?. ### Response: 21.


Instruction: What was the difference between the interven tion groups and the control group?

Output: 2 lower

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the difference between the interven tion groups and the control group?. ### Response: 2 lower.


Instruction: What is distinguished from patient-prosthesis mismatch by comparison with the early postoperative base-line study?

Output: Prosthetic valve stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is distinguished from patient-prosthesis mismatch by comparison with the early postoperative base-line study?. ### Response: Prosthetic valve stenosis.


Instruction: What is characterized by a clinical course of progressive increase in transvalvular velocity and pressure gradient?

Output: Prosthetic valve stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is characterized by a clinical course of progressive increase in transvalvular velocity and pressure gradient?. ### Response: Prosthetic valve stenosis.


Instruction: What is the term for abnormal thickened/calcified leaflets in bioprosthetic valves?

Output: Prosthetic valve stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for abnormal thickened/calcified leaflets in bioprosthetic valves?. ### Response: Prosthetic valve stenosis.


Instruction: What is best evaluated radiographically with fluoros-copy or cine-CT imaging?

Output: The motion of the leaflets of a mechanical valve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is best evaluated radiographically with fluoros-copy or cine-CT imaging?. ### Response: The motion of the leaflets of a mechanical valve.


Instruction: Why do strong reflec-tions from the mechanical valve obscure motion on echocardiographic imaging in most patients?

Output: particularly as assessed on images from the trans-thoracic approach

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why do strong reflec-tions from the mechanical valve obscure motion on echocardiographic imaging in most patients?. ### Response: particularly as assessed on images from the trans-thoracic approach.


Instruction: What must be adjusted to dem-ontrate leaflet motion from a side view?

Output: the angle of imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must be adjusted to dem-ontrate leaflet motion from a side view?. ### Response: the angle of imaging.


Instruction: What is obtained at a high frame rate focused on the prosthetic valve in a 3D acquisition?

Output: Cine-CT images

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is obtained at a high frame rate focused on the prosthetic valve in a 3D acquisition?. ### Response: Cine-CT images.


Instruction: Cine-CT 3D images are compared with what?

Output: fluoroscopy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cine-CT 3D images are compared with what?. ### Response: fluoroscopy.


Instruction: What is more operator dependent than fluoroscopy?

Output: Cine-CT images

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more operator dependent than fluoroscopy?. ### Response: Cine-CT images.


Instruction: What allows detection of pannus or thrombus on or adjacent Table 23?

Output: cine-CT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What allows detection of pannus or thrombus on or adjacent Table 23?. ### Response: cine-CT.


Instruction: Which type of Fibrinolysis is preferred over surgery for Prosthetic Valve Thrombosis?

Output: Systemic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which type of Fibrinolysis is preferred over surgery for Prosthetic Valve Thrombosis?. ### Response: Systemic.


Instruction: What type of thrombosis favors fibrinolysis?

Output: Systemic Fibrinolysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of thrombosis favors fibrinolysis?. ### Response: Systemic Fibrinolysis.


Instruction: What is low surgical risk?

Output: Readily available surgical expertise No surgical expertise available

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is low surgical risk?. ### Response: Readily available surgical expertise No surgical expertise available.


Instruction: How long is a large clot?

Output: 0.8 cm2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is a large clot?. ### Response: 0.8 cm2.


Instruction: What is the size of a small clot?

Output: ≤0.8 cm2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the size of a small clot?. ### Response: ≤0.8 cm2.


Instruction: What indicates coronary artery disease?

Output: CAD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates coronary artery disease?. ### Response: CAD.


Instruction: What is the effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocar -dial infarction?

Output: Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocar -dial infarction: results of the Survival and Ventricular Enlargement Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocar -dial infarction?. ### Response: Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocar -dial infarction: results of the Survival and Ventricular Enlargement Trial.


Instruction: What did the SAVE Investigators do?

Output: Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocar -dial infarction: results of the Survival and Ventricular Enlargement Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the SAVE Investigators do?. ### Response: Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocar -dial infarction: results of the Survival and Ventricular Enlargement Trial.


Instruction: What did ramipril do for survivors of acute myocar -dial infarction with clinical evidence of heart failure?

Output: mortality and morbidity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did ramipril do for survivors of acute myocar -dial infarction with clinical evidence of heart failure?. ### Response: mortality and morbidity.


Instruction: What does AIRE stand for?

Output: Acute Infarction Ramipril Efficacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does AIRE stand for?. ### Response: Acute Infarction Ramipril Efficacy.


Instruction: What is the name of the AIRE Study Investigators?

Output: Acute Infarction Ramipril Efficacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the AIRE Study Investigators?. ### Response: Acute Infarction Ramipril Efficacy.


Instruction: When was the Acute Infarction Ramipril Efficacy Study published?

Output: 1993

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Acute Infarction Ramipril Efficacy Study published?. ### Response: 1993.


Instruction: How many patients were treated with trandolapril?

Output: 133

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with trandolapril?. ### Response: 133.


Instruction: What is TRACE?

Output: Trandolapril Cardiac Evaluation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is TRACE?. ### Response: Trandolapril Cardiac Evaluation.


Instruction: What is the name of the study group that studies myocardial infarction?

Output: Trandolapril Cardiac Evaluation (TRACE) Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study group that studies myocardial infarction?. ### Response: Trandolapril Cardiac Evaluation (TRACE) Study Group.


Instruction: When was the trace study group founded?

Output: 1995

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the trace study group founded?. ### Response: 1995.


Instruction: How many people were in a randomized trial of the angio-tensin-receptor blocker?

Output: 134

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were in a randomized trial of the angio-tensin-receptor blocker?. ### Response: 134.


Instruction: What is valsartan used for in myocardial infarction?

Output: chronic heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is valsartan used for in myocardial infarction?. ### Response: chronic heart failure.


Instruction: What is captopril used for?

Output: morbidity and mortality in chronic heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is captopril used for?. ### Response: morbidity and mortality in chronic heart failure.


Instruction: When was the N Engl J Med 349:1893–906.

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the N Engl J Med 349:1893–906.. ### Response: 2003.


Instruction: What is the name of the study that investigated the effect of low dose losartan on clinical outcomes in patients with heart failure?

Output: HEAAL study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the effect of low dose losartan on clinical outcomes in patients with heart failure?. ### Response: HEAAL study.


Instruction: When did the HEAAL study take place?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the HEAAL study take place?. ### Response: 2009.


Instruction: What was the main effect of candesartan in heart failure patients?

Output: mortality and morbidity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the main effect of candesartan in heart failure patients?. ### Response: mortality and morbidity.


Instruction: What is the CHARM-Overall programme?

Output: Effects of candesartan on mortality and morbidity in patients with chronic heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the CHARM-Overall programme?. ### Response: Effects of candesartan on mortality and morbidity in patients with chronic heart failure.


Instruction: What is enalapril versus angiotensin-neprilysin inhibi-tion in heart failure?

Output: Angiotensin-neprilysin inhibi-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is enalapril versus angiotensin-neprilysin inhibi-tion in heart failure?. ### Response: Angiotensin-neprilysin inhibi-tion.


Instruction: When was the Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure?. ### Response: 1999.


Instruction: What is the name of the Randomised Intervention Trial in Congestive Heart Failure?

Output: MERIT-HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Randomised Intervention Trial in Congestive Heart Failure?. ### Response: MERIT-HF.


Instruction: When did the Lancet issue 353:2001-7?

Output: 1993

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Lancet issue 353:2001-7?. ### Response: 1993.


Instruction: What did the carvedilol prospective randomized cumulative survival study do?

Output: morbidity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the carvedilol prospective randomized cumulative survival study do?. ### Response: morbidity.


Instruction: What is the name of the COPERNICUS study?

Output: prospective randomized cumulative survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the COPERNICUS study?. ### Response: prospective randomized cumulative survival.


Instruction: What is eplerenone used for in patients at high risk for hyperkalemia?

Output: Safety and efficacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is eplerenone used for in patients at high risk for hyperkalemia?. ### Response: Safety and efficacy.


Instruction: What is the name of the study that looked at the effects of spironolactone on mortality in patients with severe heart failure?

Output: Randomized Aldactone Evaluation Study Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that looked at the effects of spironolactone on mortality in patients with severe heart failure?. ### Response: Randomized Aldactone Evaluation Study Investigators.


Instruction: What study did the investigators of the Randomized Aldactone Evaluation Study do?

Output: N Engl J Med. 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What study did the investigators of the Randomized Aldactone Evaluation Study do?. ### Response: N Engl J Med. 1999.


Instruction: What is the net benefi t at lower levels of stroke risk?

Output: uncertain

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the net benefi t at lower levels of stroke risk?. ### Response: uncertain.


Instruction: What is uncertain at lower levels of stroke risk?

Output: the net beneﬁ  t

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is uncertain at lower levels of stroke risk?. ### Response: the net beneﬁ  t.


Instruction: What should be kept as brief as possible given the associated increase in bleeding?

Output: The duration of triple therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be kept as brief as possible given the associated increase in bleeding?. ### Response: The duration of triple therapy.


Instruction: How long does the risk of stent thrombosis fall significantly after?

Output: 30 days with bare-metal stents and 3 to 6 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does the risk of stent thrombosis fall significantly after?. ### Response: 30 days with bare-metal stents and 3 to 6 months.


Instruction: What should be continued after 30 days with bare-metal stents and 3 to 6 months after drug-eluting?

Output: triple therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be continued after 30 days with bare-metal stents and 3 to 6 months after drug-eluting?. ### Response: triple therapy.


Instruction: What should only be continued dur-ing this high-risk period?

Output: triple therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should only be continued dur-ing this high-risk period?. ### Response: triple therapy.


Instruction: Patients at higher risk of stroke should be given what after the initial period of triple therapy?

Output: VKA therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients at higher risk of stroke should be given what after the initial period of triple therapy?. ### Response: VKA therapy.


Instruction: How long can a patient be given VKA therapy plus a single antiplatelet drug?

Output: 12 months have elapsed from the time of stent placement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long can a patient be given VKA therapy plus a single antiplatelet drug?. ### Response: 12 months have elapsed from the time of stent placement.


Instruction: What should be noted if stent placement was performed in the setting of a recent ACS?

Output: 12 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be noted if stent placement was performed in the setting of a recent ACS?. ### Response: 12 months.


Instruction: What type of stent was used to treat AF?

Output: drug-eluting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of stent was used to treat AF?. ### Response: drug-eluting.


Instruction: What is an example of a patient with AF who has received a drug-eluting sedent and is at increased risk of late sedate thrombosis?

Output: ACS at presenta-tion, diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a patient with AF who has received a drug-eluting sedent and is at increased risk of late sedate thrombosis?. ### Response: ACS at presenta-tion, diabetes.


Instruction: How long after a stent placement can a patient continue triple therapy?

Output: 12 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after a stent placement can a patient continue triple therapy?. ### Response: 12 months.


Instruction: What can be given at 12 months after implantation?

Output: antithrombotic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be given at 12 months after implantation?. ### Response: antithrombotic therapy.


Instruction: How can antithrombotic therapy be given?

Output: according to our recommendations for AF and stable coronary artery disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can antithrombotic therapy be given?. ### Response: according to our recommendations for AF and stable coronary artery disease.


Instruction: What are our recommendations for AF and stable coronary artery disease?

Output: section 3.1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are our recommendations for AF and stable coronary artery disease?. ### Response: section 3.1.


Instruction: What is the risk of stroke for patients with AF at high risk of?

Output: CHADS 2  score of 2 or greater

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of stroke for patients with AF at high risk of?. ### Response: CHADS 2  score of 2 or greater.


Instruction: During the first month after placement of a bare-metal stent?

Output: patients with AF at high risk of stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: During the first month after placement of a bare-metal stent?. ### Response: patients with AF at high risk of stroke.


Instruction: How long after placement of a bare-metal stent do we suggest triple therapy?

Output: month

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after placement of a bare-metal stent do we suggest triple therapy?. ### Response: month.


Instruction: What is the grade 2C of dual antiplatelet therapy called?

Output: CHADS 2  score of  /H11350  2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the grade 2C of dual antiplatelet therapy called?. ### Response: CHADS 2  score of  /H11350  2.


Instruction: After the initial period of 3 to 6 months, what do we recommend?

Output: triple therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: After the initial period of 3 to 6 months, what do we recommend?. ### Response: triple therapy.


Instruction: What is the grade 2C of clopidogrel?

Output: dual antiplatelet therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the grade 2C of clopidogrel?. ### Response: dual antiplatelet therapy.


Instruction: How long after intracoronary stent placement is antithrombotic therapy suggested for patients with AF and stable coronary artery disease?

Output: 12 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after intracoronary stent placement is antithrombotic therapy suggested for patients with AF and stable coronary artery disease?. ### Response: 12 months.


Instruction: What is suggested for patients with AF and stable coronary artery disease?

Output: antithrombotic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is suggested for patients with AF and stable coronary artery disease?. ### Response: antithrombotic therapy.


Instruction: How long after placement of an intra-coronary catheter is it recommended?

Output: 12 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after placement of an intra-coronary catheter is it recommended?. ### Response: 12 months.


Instruction: What is a low to intermediate risk of stroke?

Output: CHADS 2  score of 0 or 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a low to intermediate risk of stroke?. ### Response: CHADS 2  score of 0 or 1.


Instruction: How long after placement of an intra-coronary stent is antithrombotic therapy suggested?

Output: 12 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after placement of an intra-coronary stent is antithrombotic therapy suggested?. ### Response: 12 months.


Instruction: What is the grade 2C of antiplatelet therapy?

Output: dual

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the grade 2C of antiplatelet therapy?. ### Response: dual.


Instruction: At 12 months after placement, what is suggested as for patients with AF and stable coronary artery disease?

Output: antithrombotic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: At 12 months after placement, what is suggested as for patients with AF and stable coronary artery disease?. ### Response: antithrombotic therapy.


Instruction: What type of patients have AF and stable coronary artery disease?

Output: low to intermediate risk of stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of patients have AF and stable coronary artery disease?. ### Response: low to intermediate risk of stroke.


Instruction: Patients who place an exceptionally high value on stroke reduction and a low value on avoiding trials found that a 30- to 40-year-old could avoid trials?

Output: a 30

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients who place an exceptionally high value on stroke reduction and a low value on avoiding trials found that a 30- to 40-year-old could avoid trials?. ### Response: a 30.


Instruction: What did Aburto NJ, Hanson S, Gutierrez H, et al. Effect of increased potas-sium intake on cardiovascular risk factors and disease: systematic review and meta-analyses?

Output: S6.2-17

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Aburto NJ, Hanson S, Gutierrez H, et al. Effect of increased potas-sium intake on cardiovascular risk factors and disease: systematic review and meta-analyses?. ### Response: S6.2-17.


Instruction: What did Smart NA, Cornelissen V A, do?

Output: Exercise training for blood pres-sure: a systematic review and meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Smart NA, Cornelissen V A, do?. ### Response: Exercise training for blood pres-sure: a systematic review and meta-analysis.


Instruction: What isometric exercise train-ing for?

Output: blood pressure management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What isometric exercise train-ing for?. ### Response: blood pressure management.


Instruction: What is the name of the systematic review and meta-analysis of exercise training for blood pressure management?

Output: Isometric

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta-analysis of exercise training for blood pressure management?. ### Response: Isometric.


Instruction: When did the Mayo Clin Proc. 2014 release?

Output: 89:327–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Mayo Clin Proc. 2014 release?. ### Response: 89:327–.


Instruction: What did a meta-analysis of ran-domized controlled trials show about resting blood pressure in obese children?

Output: Effects of exercise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a meta-analysis of ran-domized controlled trials show about resting blood pressure in obese children?. ### Response: Effects of exercise.


Instruction: Obes Rev. 2013;14:919–28. S6.2-21. What did Rossi AM, Moullec G, Lavoie KL, et al. study?

Output: Effects of exercise on resting blood pressure in obese children: a meta-analysis of ran-domized controlled trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Obes Rev. 2013;14:919–28. S6.2-21. What did Rossi AM, Moullec G, Lavoie KL, et al. study?. ### Response: Effects of exercise on resting blood pressure in obese children: a meta-analysis of ran-domized controlled trials.


Instruction: What did the Canadian Hypertension Education Program recommend?

Output: the impact of resistance training

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Canadian Hypertension Education Program recommend?. ### Response: the impact of resistance training.


Instruction: How does resistance training affect resting blood pressure in adults?

Output: The evolution of a Canadian Hypertension Education Program recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does resistance training affect resting blood pressure in adults?. ### Response: The evolution of a Canadian Hypertension Education Program recommendation.


Instruction: What is the effect of aerobic exercise on blood pressure?

Output: a meta-analysis of randomized, controlled trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of aerobic exercise on blood pressure?. ### Response: a meta-analysis of randomized, controlled trials.


Instruction: When did a meta-analysis of randomized, controlled trials take place?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did a meta-analysis of randomized, controlled trials take place?. ### Response: 2002.


Instruction: What is the effect of alcohol reduction on blood pressure?

Output: a systematic review and meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of alcohol reduction on blood pressure?. ### Response: a systematic review and meta-analysis.


Instruction: What is a systematic review and meta-analysis of randomized controlled trials?

Output: blood pressure management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a systematic review and meta-analysis of randomized controlled trials?. ### Response: blood pressure management.


Instruction: What is the effect of alcohol consumption on blood pressure?

Output: reduc-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of alcohol consumption on blood pressure?. ### Response: reduc-tion.


Instruction: What study did Stewart SH, Latham PK, Miller PM, et al. use to reduce blood pressure during treatment for alcohol dependence?

Output: Combining Medications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What study did Stewart SH, Latham PK, Miller PM, et al. use to reduce blood pressure during treatment for alcohol dependence?. ### Response: Combining Medications.


Instruction: What is the name of the Alcoholism (COMBINE) study?

Output: Combining Medications and Behavioral Interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Alcoholism (COMBINE) study?. ### Response: Combining Medications and Behavioral Interventions.


Instruction: When did the Combinine study begin?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Combinine study begin?. ### Response: 2008.


Instruction: What did Dickinson HO, Mason JM, Nicolson DJ, et al. do to reduce raised blood pressure?

Output: Lifestyle interven-tions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Dickinson HO, Mason JM, Nicolson DJ, et al. do to reduce raised blood pressure?. ### Response: Lifestyle interven-tions.


Instruction: In what year did the J Hypertens. 2006:24:215–33?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did the J Hypertens. 2006:24:215–33?. ### Response: 2006.


Instruction: What is the name of the randomised controlled trial in France?

Output: Improving hypertension control among excessive alcohol drinkers: a randomised controlled trial in France. The WALPA Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised controlled trial in France?. ### Response: Improving hypertension control among excessive alcohol drinkers: a randomised controlled trial in France. The WALPA Group.


Instruction: In what year did the BMJ publish a study on gen-eral practitioner intervention?

Output: 1988

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did the BMJ publish a study on gen-eral practitioner intervention?. ### Response: 1988.


Instruction: What is the name of the National Institute on Alcohol Abuse and Alcoholism (NIAAA)?

Output: What Is A Standard Drink

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the National Institute on Alcohol Abuse and Alcoholism (NIAAA)?. ### Response: What Is A Standard Drink.


Instruction: What is a standard drink?

Output: National Institute on Alcohol Abuse and Alcoholism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a standard drink?. ### Response: National Institute on Alcohol Abuse and Alcoholism.


Instruction: How many RCTs were found in the CKD population?

Output: No

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs were found in the CKD population?. ### Response: No.


Instruction: What did a post hocobservational analysis69of the Modification of Diet in Renal Disease (MDRD) study population not identify?

Output: a clearrelationship between level of physical activity at baseline andthe subsequent risk of death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a post hocobservational analysis69of the Modification of Diet in Renal Disease (MDRD) study population not identify?. ### Response: a clearrelationship between level of physical activity at baseline andthe subsequent risk of death.


Instruction: Trends toward better outcomes for active individuals were observed in what study?

Output: Modiﬁcation of Diet in RenalDisease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Trends toward better outcomes for active individuals were observed in what study?. ### Response: Modiﬁcation of Diet in RenalDisease.


Instruction: What did the US Renal Data System find about CKD 5Dpatients who are sedentary have a higher risk of death than those who are active?

Output: Two largerstudies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the US Renal Data System find about CKD 5Dpatients who are sedentary have a higher risk of death than those who are active?. ### Response: Two largerstudies.


Instruction: What are the benefits of exercise on BP and on general health?

Output: similar

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the benefits of exercise on BP and on general health?. ### Response: similar.


Instruction: What are the benefits of exercise on BP and on general health similar in the CKD and the general population?

Output: The beneﬁts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the benefits of exercise on BP and on general health similar in the CKD and the general population?. ### Response: The beneﬁts.


Instruction: What was Recommendation 2.3.3 graded on?

Output: 1D

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was Recommendation 2.3.3 graded on?. ### Response: 1D.


Instruction: How many standard drinks per day do we recommend for men?

Output: two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many standard drinks per day do we recommend for men?. ### Response: two.


Instruction: How many standard drinks per day are recommended for men?

Output: two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many standard drinks per day are recommended for men?. ### Response: two.


Instruction: How many drinks are recommended per day for women?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many drinks are recommended per day for women?. ### Response: 1.


Instruction: What has been shown to produce both acute and chronic increases in BP?

Output: Alcohol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been shown to produce both acute and chronic increases in BP?. ### Response: Alcohol.


Instruction: How many trials were reviewed?

Output: four

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many trials were reviewed?. ### Response: four.


Instruction: What was the result of restricting alcohol intake in the general population?

Output: 3.8 mm Hg reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the result of restricting alcohol intake in the general population?. ### Response: 3.8 mm Hg reduction.


Instruction: How was the reduction in diastolic BP?

Output: 3.2 mm Hg reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the reduction in diastolic BP?. ### Response: 3.2 mm Hg reduction.


Instruction: There was no evidence of what?

Output: heterogeneity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There was no evidence of what?. ### Response: heterogeneity.


Instruction: No data specific to CKD patients were found, but the effects are expected to be what?

Output: similar

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No data specific to CKD patients were found, but the effects are expected to be what?. ### Response: similar.


Instruction: Most data suggest that up to how many standard drinks per day are likely to be safe for a man?

Output: two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Most data suggest that up to how many standard drinks per day are likely to be safe for a man?. ### Response: two.


Instruction: What is the definition of a standard drink?

Output: 8 to19.7 g of alcohol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the definition of a standard drink?. ### Response: 8 to19.7 g of alcohol.


Instruction: How many g of alcohol is equivalent to 30 ml of spirits?

Output: 7210

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many g of alcohol is equivalent to 30 ml of spirits?. ### Response: 7210.


Instruction: What does alcoholmoderation have on BP?

Output: increases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does alcoholmoderation have on BP?. ### Response: increases.


Instruction: What is one of the mostpotent causes of BP and general health?

Output: exercise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the mostpotent causes of BP and general health?. ### Response: exercise.


Instruction: What is another cause of health benefits?

Output: exercise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another cause of health benefits?. ### Response: exercise.


Instruction: How was recommendation 2.3.4 graded?

Output: 2D

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was recommendation 2.3.4 graded?. ### Response: 2D.


Instruction: What is one of the most modifiable risk factors for CVD in the general population and in patients with CKD?

Output: Cigarette smoking and exposure toenvironmental tobacco smoke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the most modifiable risk factors for CVD in the general population and in patients with CKD?. ### Response: Cigarette smoking and exposure toenvironmental tobacco smoke.


Instruction: The avoidance of exposure to cigarette smoke is a critical aspect of what?

Output: cardiovas-cular risk reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The avoidance of exposure to cigarette smoke is a critical aspect of what?. ### Response: cardiovas-cular risk reduction.


Instruction: What is a critical aspect of cardiovascular risk reduction?

Output: avoidance ofexposure to cigarette smoke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a critical aspect of cardiovascular risk reduction?. ### Response: avoidance ofexposure to cigarette smoke.


Instruction: There are no RCTs in the CKDpopulation.

Output: Dietary supplementation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There are no RCTs in the CKDpopulation.. ### Response: Dietary supplementation.


Instruction: What have the effects of potassium sup-plementation on?

Output: BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have the effects of potassium sup-plementation on?. ### Response: BP.


Instruction: What do CKD patients often have reduced capacity for?

Output: potassium excretion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do CKD patients often have reduced capacity for?. ### Response: potassium excretion.


Instruction: As theGFR falls, the risk of hyperkalemia may be increased.

Output: potassium excretion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: As theGFR falls, the risk of hyperkalemia may be increased.. ### Response: potassium excretion.


Instruction: What type of nurse delivers MDT?

Output: HF nurses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of nurse delivers MDT?. ### Response: HF nurses.


Instruction: What can MDT encourage?

Output: self -management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can MDT encourage?. ### Response: self -management.


Instruction: How does MDT help a patient?

Output: giving a patient confidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does MDT help a patient?. ### Response: giving a patient confidence.


Instruction: What did patients feel was often not provided to the same level in primary care?

Output: self -management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did patients feel was often not provided to the same level in primary care?. ### Response: self -management.


Instruction: How many patients with heterozygous FH took contemporary statin with or without ezetimibe treatment regimens?

Output: 404

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with heterozygous FH took contemporary statin with or without ezetimibe treatment regimens?. ### Response: 404.


Instruction: What are the independent predictors of incident ASCVD over a 5.5-year follow-up period?

Output: LDL-C levels ≥100 mg/dL (≥2.6 mmol/L)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the independent predictors of incident ASCVD over a 5.5-year follow-up period?. ### Response: LDL-C levels ≥100 mg/dL (≥2.6 mmol/L).


Instruction: What do other medical interventions that lower LDL-C levels via increased expression of LDL receptors reduce?

Output: ASCVD risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do other medical interventions that lower LDL-C levels via increased expression of LDL receptors reduce?. ### Response: ASCVD risk.


Instruction: How does increased expression of LDL receptors reduce ASCVD risk?

Output: other medical interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does increased expression of LDL receptors reduce ASCVD risk?. ### Response: other medical interventions.


Instruction: What may be considered after a clinician-patient discussion of the net benefits versus the cost of such therapy?

Output: treatment with a PCSK9 inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered after a clinician-patient discussion of the net benefits versus the cost of such therapy?. ### Response: treatment with a PCSK9 inhibitor.


Instruction: What is the cost of LDL-C-lowering therapy?

Output: 1.7 to 4.8 mmol/L

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cost of LDL-C-lowering therapy?. ### Response: 1.7 to 4.8 mmol/L.


Instruction: What is a patient with a genetic mutation associated with FH most likely to achieve the greatest benefit from?

Output: evidence-based LDL-C–lowering therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a patient with a genetic mutation associated with FH most likely to achieve the greatest benefit from?. ### Response: evidence-based LDL-C–lowering therapy.


Instruction: What is a baseline LDL-C level?

Output: ≥220 mg/dL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a baseline LDL-C level?. ### Response: ≥220 mg/dL.


Instruction: What is an on-treatment level of a PCSK9 inhibitor?

Output: ≥130 mg/dL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an on-treatment level of a PCSK9 inhibitor?. ### Response: ≥130 mg/dL.


Instruction: Patients who have maximally tolerated statin and ezetimibe therapy may be considered for treatment with what?

Output: PCSK9 inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients who have maximally tolerated statin and ezetimibe therapy may be considered for treatment with what?. ### Response: PCSK9 inhibitor.


Instruction: What is the cost-effectiveness of PCSK9 inhibitors for primary prevention among patients with LDL-C levels >190 mg/dL or with FH?

Output: has not been evaluated extensively

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cost-effectiveness of PCSK9 inhibitors for primary prevention among patients with LDL-C levels >190 mg/dL or with FH?. ### Response: has not been evaluated extensively.


Instruction: What has not been evaluated extensively?

Output: The cost-effectiveness of PCSK9 inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has not been evaluated extensively?. ### Response: The cost-effectiveness of PCSK9 inhibitors.


Instruction: How many published cost-effectiveness models for pri-mary prevention report very different results?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many published cost-effectiveness models for pri-mary prevention report very different results?. ### Response: 2.


Instruction: How much does one suggest an incremental cost effectiveness ratio per patient?

Output: $503 000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much does one suggest an incremental cost effectiveness ratio per patient?. ### Response: $503 000.


Instruction: What is the incremental cost-effectiveness ratio for PCSK9 inhibitors?

Output: $503 000 per QALY added

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the incremental cost-effectiveness ratio for PCSK9 inhibitors?. ### Response: $503 000 per QALY added.


Instruction: How much does one report per QALY added?

Output: $75 000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much does one report per QALY added?. ### Response: $75 000.


Instruction: What does the lack of consistent evidence mean about PCSK inhibitors in patients with hypercholesterolemia?

Output: uncertain value

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the lack of consistent evidence mean about PCSK inhibitors in patients with hypercholesterolemia?. ### Response: uncertain value.


Instruction: What type of hypercholesterolemia are patients with ASCVD at risk for?

Output: severe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of hypercholesterolemia are patients with ASCVD at risk for?. ### Response: severe.


Instruction: What are the Online Data Supplements 11 and 12 summarized in?

Output: Recommendations for Patients With Diabetes MellitusReferenced studies that support recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Online Data Supplements 11 and 12 summarized in?. ### Response: Recommendations for Patients With Diabetes MellitusReferenced studies that support recommendations.


Instruction: In adults 40 to 75 years of age with diabetes mellitus, regardless of estimated 10-year risk, what are the recommendations?

Output: moderate-intensity statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In adults 40 to 75 years of age with diabetes mellitus, regardless of estimated 10-year risk, what are the recommendations?. ### Response: moderate-intensity statin therapy.


Instruction: What type of statin therapy is indicated for adults with diabetes mellitus?

Output: moderate-intensity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of statin therapy is indicated for adults with diabetes mellitus?. ### Response: moderate-intensity.


Instruction: What is the LDL-C level of adults 40 to 75 years of age?

Output: 70 to 189 mg/dL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the LDL-C level of adults 40 to 75 years of age?. ### Response: 70 to 189 mg/dL.


Instruction: How long is it reasonable to assess the 10-year risk of a first ASCVD event?

Output: 5.5-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is it reasonable to assess the 10-year risk of a first ASCVD event?. ### Response: 5.5-year.


Instruction: What can race and sex-specific PCE help stratify?

Output: ASCVD risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can race and sex-specific PCE help stratify?. ### Response: ASCVD risk.


Instruction: What is the risk for children as kidney function declines?

Output: chronic kidney failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk for children as kidney function declines?. ### Response: chronic kidney failure.


Instruction: How many individuals with CKD received a high-dose ACE-I?

Output: 14

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many individuals with CKD received a high-dose ACE-I?. ### Response: 14.


Instruction: What was exceeded in 3.3% of tests?

Output: The upper limit of the normal range forchildren (5.6 mmol/l)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was exceeded in 3.3% of tests?. ### Response: The upper limit of the normal range forchildren (5.6 mmol/l).


Instruction: What percentage of tests showed that ACE-Is and ARBs have similar hemodynamic effects in the kidney?

Output: 3.3%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of tests showed that ACE-Is and ARBs have similar hemodynamic effects in the kidney?. ### Response: 3.3%.


Instruction: How many patients were treated with medical management?

Output: 5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with medical management?. ### Response: 5.


Instruction: What did medical management through adjustment of diet, addition of a diuretic or prescription of potassium-exchange resins result in?

Output: persistent normalization of serumpotassium levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did medical management through adjustment of diet, addition of a diuretic or prescription of potassium-exchange resins result in?. ### Response: persistent normalization of serumpotassium levels.


Instruction: What do ACE-Is and ARBs have similar hemodynamic effects in the kidney?

Output: decrease in GFR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do ACE-Is and ARBs have similar hemodynamic effects in the kidney?. ### Response: decrease in GFR.


Instruction: What does therapy lead to in thekidney?

Output: decrease in GFR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does therapy lead to in thekidney?. ### Response: decrease in GFR.


Instruction: How much should increase SCr level be expected?

Output: up to 30%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much should increase SCr level be expected?. ### Response: up to 30%.


Instruction: How many direct comparisons of classes of anti-hypertensiveagents have been performed in children with CKD?

Output: Few

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many direct comparisons of classes of anti-hypertensiveagents have been performed in children with CKD?. ### Response: Few.


Instruction: What has recently been pub-lished?

Output: pertensiveagents in children with CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has recently been pub-lished?. ### Response: pertensiveagents in children with CKD.


Instruction: There is no clear evidence that what is one second-lineBP agent?

Output: superior to the another in children

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is no clear evidence that what is one second-lineBP agent?. ### Response: superior to the another in children.


Instruction: How many calcium-channel blockers were used as first-choice anti-hypertensive co-medication in the ESCAPE trial?

Output: 14

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many calcium-channel blockers were used as first-choice anti-hypertensive co-medication in the ESCAPE trial?. ### Response: 14.


Instruction: What percentage of patients received diuretics?

Output: 36%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients received diuretics?. ### Response: 36%).


Instruction: How many patients received beta-blockers?

Output: 26%),

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients received beta-blockers?. ### Response: 26%),.


Instruction: What are the most suitable second-line agents?

Output: diuretics or calcium-channel block-ers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the most suitable second-line agents?. ### Response: diuretics or calcium-channel block-ers.


Instruction: In children with CKD, there is a dearth of what?

Output: RCTs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In children with CKD, there is a dearth of what?. ### Response: RCTs.


Instruction: What limits the quality of the evidence and strength of the recommendations?

Output: ESCAPE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What limits the quality of the evidence and strength of the recommendations?. ### Response: ESCAPE.


Instruction: What population was the ESCAPE trial performed in?

Output: Caucasian

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What population was the ESCAPE trial performed in?. ### Response: Caucasian.


Instruction: What is the generalization of the findings to other populations uncertain?

Output: children have not beenprospectively studied in this regard

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the generalization of the findings to other populations uncertain?. ### Response: children have not beenprospectively studied in this regard.


Instruction: What is needed to compare home BPmonitoring via oscillometric devices, ABPM, and clinic-based BP monitoring?

Output: Studies addressing BP targets

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed to compare home BPmonitoring via oscillometric devices, ABPM, and clinic-based BP monitoring?. ### Response: Studies addressing BP targets.


Instruction: What are long-term observational studies of in children with CKD?

Output: the onset of target-organ damage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are long-term observational studies of in children with CKD?. ### Response: the onset of target-organ damage.


Instruction: What are long-term observational studies necessary for?

Output: toobtain evidence on which to base thresholds for BPtreatment and targets

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are long-term observational studies necessary for?. ### Response: toobtain evidence on which to base thresholds for BPtreatment and targets.


Instruction: What is needed to base thresholds for BPtreatment and targets rather than population-based percentiles?

Output: Long-term observational studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed to base thresholds for BPtreatment and targets rather than population-based percentiles?. ### Response: Long-term observational studies.


Instruction: What type of trials are necessary to improve knowledge of the advantages and disadvantages of specific doses and classes of anti-hypertensive agents in the population?

Output: Large, long-term randomized trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of trials are necessary to improve knowledge of the advantages and disadvantages of specific doses and classes of anti-hypertensive agents in the population?. ### Response: Large, long-term randomized trials.


Instruction: What is hysterectomy and risk of cardiovascular disease?

Output: a population-based cohort study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hysterectomy and risk of cardiovascular disease?. ### Response: a population-based cohort study.


Instruction: What is the name of the population-based cohort study?

Output: Hysterectomy and risk of cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the population-based cohort study?. ### Response: Hysterectomy and risk of cardiovascular disease.


Instruction: What is oophorectomy vs ovar -ian conservation with hysterectomy: cardiovascular disease, hip fracture, and cancer in the Women’s Health Initiative Observational Study?

Output: cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is oophorectomy vs ovar -ian conservation with hysterectomy: cardiovascular disease, hip fracture, and cancer in the Women’s Health Initiative Observational Study?. ### Response: cardiovascular disease.


Instruction: What does Hormone therapy prevent in postmenopausal women?

Output: dis-ease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Hormone therapy prevent in postmenopausal women?. ### Response: dis-ease.


Instruction: What is the name of the journal that studies hormone replacement therapy and stroke?

Output: Women’s Health Initiative

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies hormone replacement therapy and stroke?. ### Response: Women’s Health Initiative.


Instruction: In what year did the journal Maturitas publish?

Output: 2001

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did the journal Maturitas publish?. ### Response: 2001.


Instruction: What study examined postmenopausal hormone therapy and risk of stroke?

Output: Heart and Estrogen-progestin Replacement Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What study examined postmenopausal hormone therapy and risk of stroke?. ### Response: Heart and Estrogen-progestin Replacement Study.


Instruction: What is the HERS?

Output: Heart and Estrogen-progestin Replacement Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the HERS?. ### Response: Heart and Estrogen-progestin Replacement Study.


Instruction: What is a clinical trial of estrogen-replacement therapy after ischemic stroke?

Output: Women’s Health Initiative randomized controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a clinical trial of estrogen-replacement therapy after ischemic stroke?. ### Response: Women’s Health Initiative randomized controlled trial.


Instruction: What is the name of the clinical trial?

Output: Women’s Health Initiative

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the clinical trial?. ### Response: Women’s Health Initiative.


Instruction: What is the name of the follow-up study for heart and estrogen/progestin replacement?

Output: HERS II

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the follow-up study for heart and estrogen/progestin replacement?. ### Response: HERS II.


Instruction: How long did hormone therapy last?

Output: prolong life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did hormone therapy last?. ### Response: prolong life.


Instruction: What is HERS II?

Output: Heart and Estrogen/progestin Replacement Study follow-up

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is HERS II?. ### Response: Heart and Estrogen/progestin Replacement Study follow-up.


Instruction: What year did JAMA publish 288:49-57?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did JAMA publish 288:49-57?. ### Response: 2002.


Instruction: What year was JAMA published?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was JAMA published?. ### Response: 2004.


Instruction: Hubbell A, Jackson R, Johnson KC, Judd H, Kotchen JM, Kuller L, LaCroix AZ, Lane D, Langer RD, Lasser N, Lewis CE, Manson J, Margolis K, Ockene J, Prentice RL, Ritenbaugh C, Robbins J, Rossouw JE, Sarto G, Stefanick ML, Van Horn L, Wactawski-Wende J, Wallace CE,

Output: Robbins J

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hubbell A, Jackson R, Johnson KC, Judd H, Kotchen JM, Kuller L, LaCroix AZ, Lane D, Langer RD, Lasser N, Lewis CE, Manson J, Margolis K, Ockene J, Prentice RL, Ritenbaugh C, Robbins J, Rossouw JE, Sarto G, Stefanick ML, Van Horn L, Wactawski-Wende J, Wallace CE,. ### Response: Robbins J.


Instruction: What did Sarto G, Stefanick ML, Van Horn L, Wactawski-Wende J, Wallace R, Wassertheil-Smoller S; Women's Health Initiative Steering Committee do?

Output: conjugated equine estrogen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Sarto G, Stefanick ML, Van Horn L, Wactawski-Wende J, Wallace R, Wassertheil-Smoller S; Women's Health Initiative Steering Committee do?. ### Response: conjugated equine estrogen.


Instruction: What was the randomized controlled trial of conjugated equine estrogen in postmenopausal women with hysterectomy?

Output: Women’s Health Initiative

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the randomized controlled trial of conjugated equine estrogen in postmenopausal women with hysterectomy?. ### Response: Women’s Health Initiative.


Instruction: What does conjugated equine estrogen do on stroke?

Output: Effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does conjugated equine estrogen do on stroke?. ### Response: Effects.


Instruction: What is the name of the organization that studies the effects of conjugated estrogen on stroke in the Women's Health Initiative?

Output: WHI Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that studies the effects of conjugated estrogen on stroke in the Women's Health Initiative?. ### Response: WHI Investigators.


Instruction: In what year did Circulation. 2006:113:2425-2434?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did Circulation. 2006:113:2425-2434?. ### Response: 2006.


Instruction: What is the name of the Writing Group for the Women’s Health Initiative?

Output: Steering Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Writing Group for the Women’s Health Initiative?. ### Response: Steering Committee.


Instruction: What is common in people with CKD?

Output: Dyslipidemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is common in people with CKD?. ### Response: Dyslipidemia.


Instruction: What does LDL-C not reliably discriminate between?

Output: those at low orhigh risk of cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does LDL-C not reliably discriminate between?. ### Response: those at low orhigh risk of cardiovascular events.


Instruction: How long did it take for a lipid profile to be measured?

Output: 1 month

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for a lipid profile to be measured?. ### Response: 1 month.


Instruction: Who should measure the lipid profile at initialpresentation with CKD?

Output: KClinicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should measure the lipid profile at initialpresentation with CKD?. ### Response: KClinicians.


Instruction: What is not required unless the results wouldchange management?

Output: lipid profileor LDL-C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not required unless the results wouldchange management?. ### Response: lipid profileor LDL-C.


Instruction: What are examples of patients in whomknowledge of LDL-C might change management?

Output: Table 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are examples of patients in whomknowledge of LDL-C might change management?. ### Response: Table 2.


Instruction: What should future studies assess to improve adherence to recommendations?

Output: clinical effectiveness and economic merits ofinterventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should future studies assess to improve adherence to recommendations?. ### Response: clinical effectiveness and economic merits ofinterventions.


Instruction: What does KExamine secular trends in adherence to recommendations in this clinical practice guideline?

Output: anysecular changes in patient outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does KExamine secular trends in adherence to recommendations in this clinical practice guideline?. ### Response: anysecular changes in patient outcomes.


Instruction: What does Kconfirm real practice safety of statin use outside of?

Output: restrictive eligibility criteria used in RCTs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Kconfirm real practice safety of statin use outside of?. ### Response: restrictive eligibility criteria used in RCTs.


Instruction: What should be studied in this population to improve the safety of statin prescribing?

Output: the frequency and severity of clinically relevant statin-drug interactions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be studied in this population to improve the safety of statin prescribing?. ### Response: the frequency and severity of clinically relevant statin-drug interactions.


Instruction: What is the cost implications of less frequent or avoidance of cholesterol measurements?

Output: confirm that lessfrequent measurements do not adversely affect theclinical benefits of treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cost implications of less frequent or avoidance of cholesterol measurements?. ### Response: confirm that lessfrequent measurements do not adversely affect theclinical benefits of treatment.


Instruction: What is one of the secondary causes of dyslipidemias?

Output: Nephrotic syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the secondary causes of dyslipidemias?. ### Response: Nephrotic syndrome.


Instruction: Excessive alcohol consumptionHypothyroidism Liver diseaseDiabetesMedications13-cis-retinoic acid AndrogensAnticonvulsants Oral contraceptivesHighly active anti-retroviral therapy CorticosteroidsDiuretics CyclosporineBeta-blockers SirolimusReproduced from what organization?

Output: National Kidney Foundation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Excessive alcohol consumptionHypothyroidism Liver diseaseDiabetesMedications13-cis-retinoic acid AndrogensAnticonvulsants Oral contraceptivesHighly active anti-retroviral therapy CorticosteroidsDiuretics CyclosporineBeta-blockers SirolimusReproduced from what organization?. ### Response: National Kidney Foundation.


Instruction: What are the Practice Guidelines for managing Dyslipidemias in Chronic Kidney Disease?

Output: K/DOQI Clinical

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Practice Guidelines for managing Dyslipidemias in Chronic Kidney Disease?. ### Response: K/DOQI Clinical.


Instruction: What is the name of the 2003 document that the National Kidney Foundation gave permission to use?

Output: Am J Kidney Dis 41

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2003 document that the National Kidney Foundation gave permission to use?. ### Response: Am J Kidney Dis 41.


Instruction: What does compression stockings prevent?

Output: post-thrombotic syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does compression stockings prevent?. ### Response: post-thrombotic syndrome.


Instruction: What is the name of the randomized, controlled trial?

Output: arandomized

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized, controlled trial?. ### Response: arandomized.


Instruction: When was the Ann Intern Med 141(4):249-256.105?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Ann Intern Med 141(4):249-256.105?. ### Response: 2004.


Instruction: What did Kahn SR, Shapiro S, Wells PS, et al. use to prevent post-thrombotic syndrome?

Output: compression stockings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Kahn SR, Shapiro S, Wells PS, et al. use to prevent post-thrombotic syndrome?. ### Response: compression stockings.


Instruction: What was the name of the randomised placebo-controlled trial that used compression stockings to treat acute leg pain associated with proximal DVT?

Output: post-thrombotic syndrome: a randomised placebo-controlled trial. Lancet . 2014;383(9920):880-888 .107. Kahn SR, Shapiro S, Ducruet T, et al. Graduated compressionstockings to treat acute leg pain associated with proximal DVT. Arandomised controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the randomised placebo-controlled trial that used compression stockings to treat acute leg pain associated with proximal DVT?. ### Response: post-thrombotic syndrome: a randomised placebo-controlled trial. Lancet . 2014;383(9920):880-888 .107. Kahn SR, Shapiro S, Ducruet T, et al. Graduated compressionstockings to treat acute leg pain associated with proximal DVT. Arandomised controlled trial.


Instruction: What is proximal DVT?

Output: Graduated compressionstockings to treat acute leg pain

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is proximal DVT?. ### Response: Graduated compressionstockings to treat acute leg pain.


Instruction: When a test is too good:how CT pulmonary angiograms find pulmonary emboli that don't need to be found?

Output: Difference in interpretation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When a test is too good:how CT pulmonary angiograms find pulmonary emboli that don't need to be found?. ### Response: Difference in interpretation.


Instruction: What is Carrier M, Righini M, Wells PS, et al?

Output: Subsegmental pulmonaryembolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Carrier M, Righini M, Wells PS, et al?. ### Response: Subsegmental pulmonaryembolism.


Instruction: How is subsegmental pulmonaryembolism diagnosed by computed tomography?

Output: incidence andclinical implications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is subsegmental pulmonaryembolism diagnosed by computed tomography?. ### Response: incidence andclinical implications.


Instruction: What did Righini M, Wells PS, and Le Gal G do?

Output: Subsegmental pulmonaryembolism diagnosed by computed tomography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Righini M, Wells PS, and Le Gal G do?. ### Response: Subsegmental pulmonaryembolism diagnosed by computed tomography.