Instruction: What was the name of the randomized Food and Drug Administration investigational de-vice exemption trial?

Output: On-X Valve Anticoagulation Clinical Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the randomized Food and Drug Administration investigational de-vice exemption trial?. ### Response: On-X Valve Anticoagulation Clinical Trial.


Instruction: What is the title of the 2014 J Thorac Cardiovasc Surg?

Output: jtcvs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of the 2014 J Thorac Cardiovasc Surg?. ### Response: jtcvs.


Instruction: What is the name of the trial that evaluated oral anticoaGulant therapy in patients with bileaflet mechanical aortic valve replacement?

Output: LOWERING-IT” Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the trial that evaluated oral anticoaGulant therapy in patients with bileaflet mechanical aortic valve replacement?. ### Response: LOWERING-IT” Trial.


Instruction: What was the outcome of the “LOWERING-IT” Trial?

Output: LOWERing the INtensity of oral anticoaGulant Therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome of the “LOWERING-IT” Trial?. ### Response: LOWERing the INtensity of oral anticoaGulant Therapy.


Instruction: What is the 9th ed of Antithrombotic Therapy and Prevention of Thrombosis?

Output: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 9th ed of Antithrombotic Therapy and Prevention of Thrombosis?. ### Response: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.


Instruction: What was the title of this 9th edition of American College of Chest Physicians Evidence Based Clinical Practice Guidelines?

Output: Antithrombotic Therapy and Prevention of Thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the title of this 9th edition of American College of Chest Physicians Evidence Based Clinical Practice Guidelines?. ### Response: Antithrombotic Therapy and Prevention of Thrombosis.


Instruction: What is another name for mitral-valve prolapse?

Output: cerebral isch-emic events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for mitral-valve prolapse?. ### Response: cerebral isch-emic events.


Instruction: When was the N Engl J Med 302:139–144 published?

Output: 1980

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the N Engl J Med 302:139–144 published?. ### Response: 1980.


Instruction: What is the name of the study that investigated the association between mitral valve prolapse and cerebral isch-emic events?

Output: N Engl J Med.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the association between mitral valve prolapse and cerebral isch-emic events?. ### Response: N Engl J Med..


Instruction: Lehman B, Benjamin EJ. Prevalence and clinical outcome of what?

Output: mitral-valve prolapse

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Lehman B, Benjamin EJ. Prevalence and clinical outcome of what?. ### Response: mitral-valve prolapse.


Instruction: N Engl J Med. 1999;341:1-7. doi: 10.1056/NEJM199907013410101 476.

Output: Prevalence and clinical outcome of mitral-valve prolapse

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: N Engl J Med. 1999;341:1-7. doi: 10.1056/NEJM199907013410101 476.. ### Response: Prevalence and clinical outcome of mitral-valve prolapse.


Instruction: What is the risk of stroke with mitral valve pro-lapse in population-based cohort study?

Output: Risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of stroke with mitral valve pro-lapse in population-based cohort study?. ### Response: Risk.


Instruction: In what year did N Engl J Med issue 341:8–13?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did N Engl J Med issue 341:8–13?. ### Response: 1999.


Instruction: What is the name of the study that compared annular calcification and aortic valve sclerosis with brain findings on magnetic resonance imaging in community dwelling older adults?

Output: the Cardiovascular Health Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that compared annular calcification and aortic valve sclerosis with brain findings on magnetic resonance imaging in community dwelling older adults?. ### Response: the Cardiovascular Health Study.


Instruction: What is the name of the study of community dwelling older adults?

Output: Cardiovascular Health Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study of community dwelling older adults?. ### Response: Cardiovascular Health Study.


Instruction: When was the J Am Coll Cardiol 57:2172–2180 published?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol 57:2172–2180 published?. ### Response: 2011.


Instruction: What is the Strong Heart Study?

Output: incident stroke in adults free of clinical cardiovas-cular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Strong Heart Study?. ### Response: incident stroke in adults free of clinical cardiovas-cular disease.


Instruction: What is a risk factor for stroke after initial cerebral ischemia?

Output: Mitral valve prolapse

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for stroke after initial cerebral ischemia?. ### Response: Mitral valve prolapse.


Instruction: After initial cerebral ischemia, what is the name of the disease?

Output: Mitral valve prolapse and the risk of stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: After initial cerebral ischemia, what is the name of the disease?. ### Response: Mitral valve prolapse and the risk of stroke.


Instruction: How many patients were followed up in 1985?

Output: 237

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were followed up in 1985?. ### Response: 237.


Instruction: What was the length of the follow-up?

Output: 237 patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the length of the follow-up?. ### Response: 237 patients.


Instruction: What are the multiple functional domains of the heparin molecule?

Output: unfraction-ated heparin, dermatan sulfate and low molecular weight

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the multiple functional domains of the heparin molecule?. ### Response: unfraction-ated heparin, dermatan sulfate and low molecular weight.


Instruction: What is the 78 ( 2 ): 829 - 833?

Output: Multiple functional domains of the heparin molecule

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 78 ( 2 ): 829 - 833?. ### Response: Multiple functional domains of the heparin molecule.


Instruction: S, Lindhout T, Hemker HC. What is the mode of action of heparin in plasma?

Output: aggregation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: S, Lindhout T, Hemker HC. What is the mode of action of heparin in plasma?. ### Response: aggregation.


Instruction: How does heparin affect vessel wall permeability in rabbits?

Output: unfraction-ated heparin, dermatan sulfate and low molecular weight

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does heparin affect vessel wall permeability in rabbits?. ### Response: unfraction-ated heparin, dermatan sulfate and low molecular weight.


Instruction: What is the effect of dermatan sulfate on vessel wall?

Output: platelet defect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of dermatan sulfate on vessel wall?. ### Response: platelet defect.


Instruction: How is vessel wall permeability measured in rabbits?

Output: unfraction-ated heparin, dermatan sulfate and low molecular weight heparin on vessel wall permeability in rabbits .   Ann N Y Acad Sci  .  1989 ; 556 : 245 - 254

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is vessel wall permeability measured in rabbits?. ### Response: unfraction-ated heparin, dermatan sulfate and low molecular weight heparin on vessel wall permeability in rabbits .   Ann N Y Acad Sci  .  1989 ; 556 : 245 - 254.


Instruction: What is the name of the scientific journal published in 1989?

Output: Ann N Y Acad Sci

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the scientific journal published in 1989?. ### Response: Ann N Y Acad Sci.


Instruction: How many pages were in 1989's Ann NY Acad Sci?

Output: 556

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many pages were in 1989's Ann NY Acad Sci?. ### Response: 556.


Instruction: What is critical to the expression of the anticoagulant effect of heparin?

Output: inhibition of throm-bin-dependent positive-feedback reactions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is critical to the expression of the anticoagulant effect of heparin?. ### Response: inhibition of throm-bin-dependent positive-feedback reactions.


Instruction: What is the inhibition of throm-bin-dependent positive-feedback reactions?

Output: critical to the expression of the ant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the inhibition of throm-bin-dependent positive-feedback reactions?. ### Response: critical to the expression of the ant.


Instruction: What drug inhibited thrombin induced aggregation of human platelets by heparin?

Output: Eika   C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug inhibited thrombin induced aggregation of human platelets by heparin?. ### Response: Eika   C.


Instruction: What year did Scand J Haematol publish?

Output: 1971

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Scand J Haematol publish?. ### Response: 1971.


Instruction: How many haematols were there in 1971?

Output: 216 - 222

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many haematols were there in 1971?. ### Response: 216 - 222.


Instruction: What was the number of haematols in 1971 that were 216 - 222?

Output: Scand J Haematol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the number of haematols in 1971 that were 216 - 222?. ### Response: Scand J Haematol.


Instruction: Kelton JG, Hirsh J. What is Bleeding associated with with antithrombotic therapy?

Output: Different intensities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Kelton JG, Hirsh J. What is Bleeding associated with with antithrombotic therapy?. ### Response: Different intensities.


Instruction: What year was Semin Hematol published?

Output: 1980

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was Semin Hematol published?. ### Response: 1980.


Instruction: What was the number of publications in 1980?

Output: 17

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the number of publications in 1980?. ### Response: 17.


Instruction: What is the effect of heparin fractions on plate-let aggregation?

Output: induce a platelet defect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of heparin fractions on plate-let aggregation?. ### Response: induce a platelet defect.


Instruction: What was the J Clin Invest in 1980?

Output: 64 - 73

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the J Clin Invest in 1980?. ### Response: 64 - 73.


Instruction: What does heparin impair in primary haemostasis and platelet release?

Output: smooth muscle cell proliferation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does heparin impair in primary haemostasis and platelet release?. ### Response: smooth muscle cell proliferation.


Instruction: What is the name of the drug that impairs the release of platelet [14C]5-hydroxytryptamine?

Output: heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug that impairs the release of platelet [14C]5-hydroxytryptamine?. ### Response: heparin.


Instruction: What was the release of [14C]5-hydroxytryptamine?

Output: Impairment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the release of [14C]5-hydroxytryptamine?. ### Response: Impairment.


Instruction: What year did Br J Haematol publish 36 ( 3 ): 427-436?

Output: 1977

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Br J Haematol publish 36 ( 3 ): 427-436?. ### Response: 1977.


Instruction: What does heparin and other glycosaminoglycans induce?

Output: a platelet defect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does heparin and other glycosaminoglycans induce?. ### Response: a platelet defect.


Instruction: What is a platelet defect?

Output: Hemorrhagic doses of heparin and other glycosaminoglycans

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a platelet defect?. ### Response: Hemorrhagic doses of heparin and other glycosaminoglycans.


Instruction: Thromb Res. 1986 ; 43 ( 4 ): 491 - 495.

Output: 1986

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Thromb Res. 1986 ; 43 ( 4 ): 491 - 495.. ### Response: 1986.


Instruction: What is the treatment of proximal-vein throm-bosis called?

Output: oral anti-coagulant therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the treatment of proximal-vein throm-bosis called?. ### Response: oral anti-coagulant therapy.


Instruction: What was the N Engl J Med in 1982?

Output: 1676 - 1681

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the N Engl J Med in 1982?. ### Response: 1676 - 1681.


Instruction: How many (27): 1676 - 1681?

Output: 307

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many (27): 1676 - 1681?. ### Response: 307.


Instruction: What is a possible role of a platelet endo-glycosidase?

Output: Inhibition of vascular smooth muscle cell growth by endo-thelial cell-derived heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a possible role of a platelet endo-glycosidase?. ### Response: Inhibition of vascular smooth muscle cell growth by endo-thelial cell-derived heparin.


Instruction: What is inhibition of vascular smooth muscle cell growth by?

Output: heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is inhibition of vascular smooth muscle cell growth by?. ### Response: heparin.


Instruction: What is heparin derived from?

Output: endo-thelial cell

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is heparin derived from?. ### Response: endo-thelial cell.


Instruction: What is possible role of a platelet endo-glycosidase?

Output: Inhibition of vascular smooth muscle cell growth by endo-thelial cell-derived heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is possible role of a platelet endo-glycosidase?. ### Response: Inhibition of vascular smooth muscle cell growth by endo-thelial cell-derived heparin.


Instruction: When was J Biol Chem 257 ( 19 ): 11256- 11260?

Output: 1982

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was J Biol Chem 257 ( 19 ): 11256- 11260?. ### Response: 1982.


Instruction: How is smooth muscle cell proliferation suppressed by heparin in injured arteries?

Output: Hemorrhagic doses of heparin and other glycosaminoglycans induce a platelet defect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is smooth muscle cell proliferation suppressed by heparin in injured arteries?. ### Response: Hemorrhagic doses of heparin and other glycosaminoglycans induce a platelet defect.


Instruction: What is the name of the study published in 1977?

Output: Br J Haematol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study published in 1977?. ### Response: Br J Haematol.


Instruction: How many ( 5595 ): 625-626?

Output: 265

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many ( 5595 ): 625-626?. ### Response: 265.


Instruction: What are the effects of standard and low molecular weight?

Output: bone nodule formation in vitro

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the effects of standard and low molecular weight?. ### Response: bone nodule formation in vitro.


Instruction: How does heparin affect bone nodule formation in vitro?

Output: low molecular weight

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does heparin affect bone nodule formation in vitro?. ### Response: low molecular weight.


Instruction: When was Thromb Haemost published?

Output: 1998

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Thromb Haemost published?. ### Response: 1998.


Instruction: Who wrote the 2012 American College of Chest Physicians?

Output: Kimberly Henricks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote the 2012 American College of Chest Physicians?. ### Response: Kimberly Henricks.


Instruction: Who wrote the book College of Chest Physicians?

Output: Kimberly Henricks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote the book College of Chest Physicians?. ### Response: Kimberly Henricks.


Instruction: When did Kimberly Henricks publish the book?

Output: February 10, 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Kimberly Henricks publish the book?. ### Response: February 10, 2012.


Instruction: What is the focus of the Meta-Analysis of Effectiveness and Safety of Oral Anticoagulants in Atrial Fibrillation with Focus onApixaban?

Output: randomized controlled trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the focus of the Meta-Analysis of Effectiveness and Safety of Oral Anticoagulants in Atrial Fibrillation with Focus onApixaban?. ### Response: randomized controlled trials.


Instruction: What are the considerations on once- vs. twice-daily regimens?

Output: their potential impact on medication adherence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the considerations on once- vs. twice-daily regimens?. ### Response: their potential impact on medication adherence.


Instruction: What is the potential impact of twice-daily regimens on medication adherence?

Output: Non-vitamin K antagonist oralanticoagulants: considerations on once- vs. twice-daily regimensand their potential impact on medication adherence. Europace .2015;17(4):514-523 .200

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the potential impact of twice-daily regimens on medication adherence?. ### Response: Non-vitamin K antagonist oralanticoagulants: considerations on once- vs. twice-daily regimensand their potential impact on medication adherence. Europace .2015;17(4):514-523 .200.


Instruction: What is a meta-analysis of randomized controlled trials in Asian patients withatrial fibrillation?

Output: Once- or twice-daily non-vitamin K antagonist oral anticoagulants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a meta-analysis of randomized controlled trials in Asian patients withatrial fibrillation?. ### Response: Once- or twice-daily non-vitamin K antagonist oral anticoagulants.


Instruction: Med Assoc. 2017;116(8):591-598.201 What is the name of the drug used to prevent stroke in elderly Chinese patients with atrial fibrillation?

Output: dabigatran

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Med Assoc. 2017;116(8):591-598.201 What is the name of the drug used to prevent stroke in elderly Chinese patients with atrial fibrillation?. ### Response: dabigatran.


Instruction: HeartRhythm. 2016;13(2):366-373.202 What is a North American Perspective-2016 Update?

Output: Antithrombotictherapy in patients with atrial ﬁbrillation undergoing percutaneouscoronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: HeartRhythm. 2016;13(2):366-373.202 What is a North American Perspective-2016 Update?. ### Response: Antithrombotictherapy in patients with atrial ﬁbrillation undergoing percutaneouscoronary intervention.


Instruction: What is a North American Perspective-2016 Update?

Output: Antithrombotictherapy in patients with atrial ﬁbrillation undergoing percutaneouscoronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a North American Perspective-2016 Update?. ### Response: Antithrombotictherapy in patients with atrial ﬁbrillation undergoing percutaneouscoronary intervention.


Instruction: What is the European Heart Rhythm Association's consensus document?

Output: EHRA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the European Heart Rhythm Association's consensus document?. ### Response: EHRA.


Instruction: What are the acronyms for Heart Rhythm Society?

Output: Asia Paci ﬁc Heart Rhythm Society (APHRS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the acronyms for Heart Rhythm Society?. ### Response: Asia Paci ﬁc Heart Rhythm Society (APHRS.


Instruction: What is the acronym for Asia Paci fic Heart Rhytm Society? What is SOLEACE?

Output: SociedadLatinoamericana de Estimulacion Cardiaca y Electro ﬁsiologia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Asia Paci fic Heart Rhytm Society? What is SOLEACE?. ### Response: SociedadLatinoamericana de Estimulacion Cardiaca y Electro ﬁsiologia.


Instruction: How is bleeding managed?

Output: non-vitamin K antagonist oral anticoagulants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is bleeding managed?. ### Response: non-vitamin K antagonist oral anticoagulants.


Instruction: What is the name of the European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist anticoagulants in patients with non-valvularatrial fibrillation?

Output: Updated

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist anticoagulants in patients with non-valvularatrial fibrillation?. ### Response: Updated.


Instruction: What year did Europace publish its 17(10):1467-1507?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Europace publish its 17(10):1467-1507?. ### Response: 2015.


Instruction: What does Flaker GC, Saxonhouse SJ, et al. do in patients with atrial fibrillation?

Output: Practical managementof anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Flaker GC, Saxonhouse SJ, et al. do in patients with atrial fibrillation?. ### Response: Practical managementof anticoagulation.


Instruction: What is the J Am CollCardiol. 2015;65(13):1340-1360.207?

Output: Practical managementof anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the J Am CollCardiol. 2015;65(13):1340-1360.207?. ### Response: Practical managementof anticoagulation.


Instruction: How is bleeding managed inpatients receiving oral anticoagulants?

Output: Practical

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is bleeding managed inpatients receiving oral anticoagulants?. ### Response: Practical.


Instruction: What does Aronis KN, Hylek EM say about non-vitamin K oral anticoagulants?

Output: Who, when, and how to reverse

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Aronis KN, Hylek EM say about non-vitamin K oral anticoagulants?. ### Response: Who, when, and how to reverse.


Instruction: What is the effect of activated charcoal onapixaban pharmacokinetics?

Output: healthy subjects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of activated charcoal onapixaban pharmacokinetics?. ### Response: healthy subjects.


Instruction: What is a positive outcome afterintentional overdose of dabigatran?

Output: Stroke prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a positive outcome afterintentional overdose of dabigatran?. ### Response: Stroke prevention.


Instruction: What is one lesson for managing new oralanticoagulants?

Output: Accidental rivaroxaban overdose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one lesson for managing new oralanticoagulants?. ### Response: Accidental rivaroxaban overdose.


Instruction: How does rivaroxaban overdose in a patient withpulmonary embolism?

Output: Accidental

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does rivaroxaban overdose in a patient withpulmonary embolism?. ### Response: Accidental.


Instruction: What is the name of the anovel, reversible, oral direct thrombin inhibitor?

Output: Dabigatran etexilate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the anovel, reversible, oral direct thrombin inhibitor?. ### Response: Dabigatran etexilate.


Instruction: What are reviewers required to complete and submit?

Output: Questionnaire

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are reviewers required to complete and submit?. ### Response: Questionnaire.


Instruction: What is a relationship considered to be if the person receives $10 000 or more during a 12-month period?

Output: significant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a relationship considered to be if the person receives $10 000 or more during a 12-month period?. ### Response: significant.


Instruction: How much of the voting stock or share of the entity does the person own?

Output: 5% or more

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the voting stock or share of the entity does the person own?. ### Response: 5% or more.


Instruction: What is a relationship considered to be if it is less than “significant” under the preceding definition?

Output: modest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a relationship considered to be if it is less than “significant” under the preceding definition?. ### Response: modest.


Instruction: What is less than “significant” under the preceding definition?

Output: A relationship

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is less than “significant” under the preceding definition?. ### Response: A relationship.


Instruction: When was MODEST.Downloaded from?

Output: April 26, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was MODEST.Downloaded from?. ### Response: April 26, 2023.


Instruction: Antiplatelets; aPTT; angiotensin receptor blocker; ASA; aspirin; AT; what?

Output: antithrombins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Antiplatelets; aPTT; angiotensin receptor blocker; ASA; aspirin; AT; what?. ### Response: antithrombins.


Instruction: BID; twice daily; BMS; bare-metal stent; what does BMS stand for?

Output: antiplatelets

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: BID; twice daily; BMS; bare-metal stent; what does BMS stand for?. ### Response: antiplatelets.


Instruction: DAPT; dual antiplatelet therapy; EC; GFR; GP; what is HPR?

Output: high platelet reactivity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: DAPT; dual antiplatelet therapy; EC; GFR; GP; what is HPR?. ### Response: high platelet reactivity.


Instruction: What is GFR?

Output: glomerular filtration rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is GFR?. ### Response: glomerular filtration rate.


Instruction: What is GI?

Output: gastrointestinal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is GI?. ### Response: gastrointestinal.


Instruction: How is HPR defined?

Output: high platelet reactivity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is HPR defined?. ### Response: high platelet reactivity.


Instruction: What is OH?

Output: orthostatic hypotension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is OH?. ### Response: orthostatic hypotension.


Instruction: What is PCI?

Output: percutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PCI?. ### Response: percutaneous coronary intervention.


Instruction: How often does PCI take place?

Output: once daily

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often does PCI take place?. ### Response: once daily.


Instruction: SCr is what?

Output: serum creatinine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: SCr is what?. ### Response: serum creatinine.


Instruction: Why was the evidence for improvement in class I NYHA graded as low quality?

Output: imprecision and indirectness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the evidence for improvement in class I NYHA graded as low quality?. ### Response: imprecision and indirectness.


Instruction: What was the risk of bias?

Output: lack of blinding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk of bias?. ### Response: lack of blinding.


Instruction: The study only reported numbers in class 1 NYHA at the end of the trial rather than all of them?

Output: I

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The study only reported numbers in class 1 NYHA at the end of the trial rather than all of them?. ### Response: I.


Instruction: What was the evidence for all outcomes of the trial?

Output: very low quality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the evidence for all outcomes of the trial?. ### Response: very low quality.


Instruction: What did the evidence have for mortality over the duration of the study?

Output: very s erious imprecision and high risk of bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the evidence have for mortality over the duration of the study?. ### Response: very s erious imprecision and high risk of bias.


Instruction: How was the quality of life evidence downgraded?

Output: for imprecision and risk of bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the quality of life evidence downgraded?. ### Response: for imprecision and risk of bias.


Instruction: What is the term for unbalanced baseline characteristics between groups?

Output: bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for unbalanced baseline characteristics between groups?. ### Response: bias.


Instruction: What is the maximum dose of IV alteplase over 60 mg?

Output: 90 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the maximum dose of IV alteplase over 60 mg?. ### Response: 90 mg.


Instruction: How long does it take to administer IV altepase in patients with AIS indications?

Output: Within 3 h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take to administer IV altepase in patients with AIS indications?. ### Response: Within 3 h.


Instruction: What are the Eligibility Recommendations for?

Output: IV Alteplase in Patients With AISIndications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Eligibility Recommendations for?. ### Response: IV Alteplase in Patients With AISIndications.


Instruction: What is the maximum dose of IV alteplase?

Output: 90 mg over 60 min

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the maximum dose of IV alteplase?. ### Response: 90 mg over 60 min.


Instruction: What is recommended for patients who may be treated within 3 h of ischemic stroke symptom onset?

Output: IV alteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for patients who may be treated within 3 h of ischemic stroke symptom onset?. ### Response: IV alteplase.


Instruction: Who should review the criteria outlined in this table to determine patient eligibility?

Output: Physicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should review the criteria outlined in this table to determine patient eligibility?. ### Response: Physicians.


Instruction: Who should administer IV alteplase within 3 h–Age?

Output: the physician

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should administer IV alteplase within 3 h–Age?. ### Response: the physician.


Instruction: What is equally recommended for patients 80 and >80 y of age?

Output: IV alteplase administration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is equally recommended for patients 80 and >80 y of age?. ### Response: IV alteplase administration.


Instruction: What is IV alteplase indicated within 3 h from symptom onset of ischemic stroke?

Output: For severe stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is IV alteplase indicated within 3 h from symptom onset of ischemic stroke?. ### Response: For severe stroke.


Instruction: What is the risk of hemorrhagic transformation for stroke patients?

Output: increased risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of hemorrhagic transformation for stroke patients?. ### Response: increased risk.


Instruction: What is IV alteplase recommended for patients with mild but disabling stroke symptoms?

Output: within 3 h of ischemic stroke symptom onset or patient last known well or at baseline state

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is IV alteplase recommended for patients with mild but disabling stroke symptoms?. ### Response: within 3 h of ischemic stroke symptom onset or patient last known well or at baseline state.


Instruction: What is IV alteplase recommended for?

Output: selected patients who may be treated within 3 h of ischemic stroke symptom onset or patient last known well or at baseline state

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is IV alteplase recommended for?. ### Response: selected patients who may be treated within 3 h of ischemic stroke symptom onset or patient last known well or at baseline state.


Instruction: What is recommended for patients who can be treated within 3 h of ischemic stroke symptom onset or patient last known well?

Output: IV alteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for patients who can be treated within 3 h of ischemic stroke symptom onset or patient last known well?. ### Response: IV alteplase.


Instruction: How long is 60 min with 10% of dose given as bolus over 1 min?

Output: 3–4.5 h*

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is 60 min with 10% of dose given as bolus over 1 min?. ### Response: 3–4.5 h*.


Instruction: What is recommended for patients who can be treated within 3 and 4.5 h of ischemic stroke symptom onset or patient last known well?

Output: IV alteplase is recommended for patients who can be treated within 3 h of ischemic stroke symptom onset or patient last known well or at baseline state ( COR I; LOE B-R)‡ 3–4.5 h* IV alteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for patients who can be treated within 3 and 4.5 h of ischemic stroke symptom onset or patient last known well?. ### Response: IV alteplase is recommended for patients who can be treated within 3 h of ischemic stroke symptom onset or patient last known well or at baseline state ( COR I; LOE B-R)‡ 3–4.5 h* IV alteplase.


Instruction: What is the time window for IV alteplase treatment?

Output: 3- to 4.5-h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the time window for IV alteplase treatment?. ### Response: 3- to 4.5-h.


Instruction: What is recommended for patients 80 y of age, without a history of diabetes mellitus and prior stroke?

Output: IV alteplase treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for patients 80 y of age, without a history of diabetes mellitus and prior stroke?. ### Response: IV alteplase treatment.


Instruction: What should be initiated as quickly as possible within the above-listed time frames?

Output: Urgency Treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be initiated as quickly as possible within the above-listed time frames?. ### Response: Urgency Treatment.


Instruction: How much of the MCA territory does ischemic injury affect?

Output: one-third

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the MCA territory does ischemic injury affect?. ### Response: one-third.


Instruction: Why is time to treatment strongly associated with outcomes?

Output: Urgency Treatment should be initiated as quickly as possible within the above-listed time frames

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is time to treatment strongly associated with outcomes?. ### Response: Urgency Treatment should be initiated as quickly as possible within the above-listed time frames.


Instruction: What is recommended in patients with BP 185/110 mm Hg?

Output: BP IV alteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended in patients with BP 185/110 mm Hg?. ### Response: BP IV alteplase.


Instruction: How can BP be lowered safely to this level with antihypertensive agents?

Output: with the physician assessing the stability of the BP before starting IV alteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can BP be lowered safely to this level with antihypertensive agents?. ### Response: with the physician assessing the stability of the BP before starting IV alteplase.


Instruction: What can be safely lowered to this level with antihypertensive agents?

Output: BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be safely lowered to this level with antihypertensive agents?. ### Response: BP.


Instruction: What is recommended in otherwise eligible patients with initial glucose levels >50 mg/dL?

Output: Blood glucose IV alteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended in otherwise eligible patients with initial glucose levels >50 mg/dL?. ### Response: Blood glucose IV alteplase.


Instruction: Who assesses the stability of the BP before starting IV alteplase?

Output: the physician

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who assesses the stability of the BP before starting IV alteplase?. ### Response: the physician.


Instruction: What dose of CT IV alteplase is recommended in the setting of early ischemic changes on NCCT of mild to moderate extent?

Output: frank hypodensity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What dose of CT IV alteplase is recommended in the setting of early ischemic changes on NCCT of mild to moderate extent?. ### Response: frank hypodensity.


Instruction: What do patients without hypotension who are at the severe end of the spectrum need to be treated with?

Output: aggressive anticoagulation and other supportivemeasures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do patients without hypotension who are at the severe end of the spectrum need to be treated with?. ### Response: aggressive anticoagulation and other supportivemeasures.


Instruction: What does development of hypotension suggest that thrombolytic therapy has become?

Output: indicated

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does development of hypotension suggest that thrombolytic therapy has become?. ### Response: indicated.


Instruction: What therapy has becomeindicated?

Output: thrombolytic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What therapy has becomeindicated?. ### Response: thrombolytic therapy.


Instruction: What may prompt the use of thrombolytictherapy?

Output: Deterioration that has not resulted inhypotension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may prompt the use of thrombolytictherapy?. ### Response: Deterioration that has not resulted inhypotension.


Instruction: Deterioration that has not resulted inhypotension may prompt what?

Output: thrombolytictherapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Deterioration that has not resulted inhypotension may prompt what?. ### Response: thrombolytictherapy.


Instruction: What are some signs of shock?

Output: cold sweaty skin, reduced urine output,confusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some signs of shock?. ### Response: cold sweaty skin, reduced urine output,confusion.


Instruction: What is a progressive right heart dysfunction onechocardiography?

Output: an increase in cardiac biomarkers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a progressive right heart dysfunction onechocardiography?. ### Response: an increase in cardiac biomarkers.


Instruction: What do we recommend for patients with hypotension who have right ventriculardysfunction and an increase in cardiac biomarkers?

Output: thrombolytic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do we recommend for patients with hypotension who have right ventriculardysfunction and an increase in cardiac biomarkers?. ### Response: thrombolytic therapy.


Instruction: What does echocardiography and/or measurement ofcardiac biomarkers do?

Output: assessment of right ventricularfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does echocardiography and/or measurement ofcardiac biomarkers do?. ### Response: assessment of right ventricularfunction.


Instruction: What is an example of a patient with acute PE associated withhypotension?

Output: systolic BP <90 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a patient with acute PE associated withhypotension?. ### Response: systolic BP <90 mm Hg.


Instruction: What is the grade of thrombolytic therapy for patients with BP 90 mm Hg?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the grade of thrombolytic therapy for patients with BP 90 mm Hg?. ### Response: >.


Instruction: What is grade 2B?

Output: no suchtherapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is grade 2B?. ### Response: no suchtherapy.


Instruction: In most patients with acute PE not associated with hypotension, we recommend against what?

Output: systemi-cally administered thrombolytic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In most patients with acute PE not associated with hypotension, we recommend against what?. ### Response: systemi-cally administered thrombolytic therapy.


Instruction: How do patients with PE deteriorate after starting anticoagulant therapy?

Output: systemically administeredthrombolytic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do patients with PE deteriorate after starting anticoagulant therapy?. ### Response: systemically administeredthrombolytic therapy.


Instruction: What should patients with PE and without hypotension be monitored closely for?

Output: deterioration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients with PE and without hypotension be monitored closely for?. ### Response: deterioration.


Instruction: What is the grade 2C of therapy?

Output: no such therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the grade 2C of therapy?. ### Response: no such therapy.


Instruction: What should be closely monitored for?

Output: deteriorations are detected

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be closely monitored for?. ### Response: deteriorations are detected.


Instruction: Development of hypotension suggests thatthrombolytic therapy has become indicated?

Output: fordeterioration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Development of hypotension suggests thatthrombolytic therapy has become indicated?. ### Response: fordeterioration.


Instruction: Cardiopulmonary deterioration that has not progressed to hypotension may alter what?

Output: the risk-bene

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cardiopulmonary deterioration that has not progressed to hypotension may alter what?. ### Response: the risk-bene.


Instruction: What type of therapy is preferred in patients initially treated withanticoagulation alone?

Output: thrombolytic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is preferred in patients initially treated withanticoagulation alone?. ### Response: thrombolytic.


Instruction: What is used for the initial treatment of PES?

Output: Catheter-Based Thrombus Removal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used for the initial treatment of PES?. ### Response: Catheter-Based Thrombus Removal.


Instruction: Where can catheter-based treatments be used?

Output: acute PE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can catheter-based treatments be used?. ### Response: acute PE.


Instruction: What is centrally acting antihypertensive agents an update on?

Output: J ClinHypertens

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is centrally acting antihypertensive agents an update on?. ### Response: J ClinHypertens.


Instruction: What is the name of the journal in Greenwich that published the 2007 issue of J ClinHypertens?

Output: J ClinHypertens

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal in Greenwich that published the 2007 issue of J ClinHypertens?. ### Response: J ClinHypertens.


Instruction: Who is the author of Moxonidine treatment of patients with renal failure?

Output: Russ H

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of Moxonidine treatment of patients with renal failure?. ### Response: Russ H.


Instruction: What does MOXCON stand for?

Output: heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does MOXCON stand for?. ### Response: heart failure.


Instruction: What is the name of the drug that has been shown to have a negative effect on heart failure?

Output: MOXCON

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug that has been shown to have a negative effect on heart failure?. ### Response: MOXCON.


Instruction: In what year did Eur J Heart Fail issue 5:659-667.137?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did Eur J Heart Fail issue 5:659-667.137?. ### Response: 2003.


Instruction: What is a high-risk combination of chronic kidney disease stages1 to 4 and cardiovascular disease?

Output: The epidemiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a high-risk combination of chronic kidney disease stages1 to 4 and cardiovascular disease?. ### Response: The epidemiology.


Instruction: What is an example of a large-managed care organization with chronic kidney diseases?

Output: community-based population

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a large-managed care organization with chronic kidney diseases?. ### Response: community-based population.


Instruction: What is a blood pressure target in chronic kidney disease and proteinuria as an effectmodifier?

Output: Systematic review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a blood pressure target in chronic kidney disease and proteinuria as an effectmodifier?. ### Response: Systematic review.


Instruction: What is an Intensive blood-pressure control in?

Output: hypertensive chronic kidney disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an Intensive blood-pressure control in?. ### Response: hypertensive chronic kidney disease.


Instruction: What type of chronic kidney disease is controlled by angiotensin-converting enzyme inhibitors?

Output: nondiabetic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of chronic kidney disease is controlled by angiotensin-converting enzyme inhibitors?. ### Response: nondiabetic.


Instruction: What is the name of the meta-analysis of patient-level data?

Output: Angiotensin-converting enzymeinhibitors and progression of nondiabetic renal disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis of patient-level data?. ### Response: Angiotensin-converting enzymeinhibitors and progression of nondiabetic renal disease.


Instruction: When was the Ann Intern Med 135:73–87.142 published?

Output: 2001

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Ann Intern Med 135:73–87.142 published?. ### Response: 2001.


Instruction: What is the name of the study that examined blood pressure control, proteinuria, and the progression of renal disease?

Output: The Modiﬁcation of Diet in RenalDisease Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined blood pressure control, proteinuria, and the progression of renal disease?. ### Response: The Modiﬁcation of Diet in RenalDisease Study.


Instruction: What is a major factor in the development of renal diseases?

Output: Blood pressure control, proteinuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a major factor in the development of renal diseases?. ### Response: Blood pressure control, proteinuria.


Instruction: When was the Modification of Diet in RenalDisease Study published?

Output: 1995

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Modification of Diet in RenalDisease Study published?. ### Response: 1995.


Instruction: What was the name of the report released by the JointNational Committee on Prevention, Detection, Evaluation, and Treat-ment of High Blood Pressure?

Output: The Seventh Report

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the report released by the JointNational Committee on Prevention, Detection, Evaluation, and Treat-ment of High Blood Pressure?. ### Response: The Seventh Report.


Instruction: When was the JNC 7 report released?

Output: Seventh

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the JNC 7 report released?. ### Response: Seventh.


Instruction: What did Vasan RS, Larson MG, Leip EP and Foxes do?

Output: Predictors of new-onset kidney diseasein a community-based population

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Vasan RS, Larson MG, Leip EP and Foxes do?. ### Response: Predictors of new-onset kidney diseasein a community-based population.


Instruction: What is a risk factor for end-stage renaldisease?

Output: 25-year follow-up

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for end-stage renaldisease?. ### Response: 25-year follow-up.


Instruction: What was the N Engl J Med 2001: 345: 1291– 1297.145?

Output: high-normal blood pressureon the risk of cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the N Engl J Med 2001: 345: 1291– 1297.145?. ### Response: high-normal blood pressureon the risk of cardiovascular disease.


Instruction: How long was the follow-up period?

Output: 25-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the follow-up period?. ### Response: 25-year.


Instruction: How long is the follow-up period for end-stage renaldisease?

Output: 25-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the follow-up period for end-stage renaldisease?. ### Response: 25-year.


Instruction: How long does the follow up period last?

Output: 25-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does the follow up period last?. ### Response: 25-year.


Instruction: What is the risk associated with elevated blood pressure?

Output: end-stage renal disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk associated with elevated blood pressure?. ### Response: end-stage renal disease.


Instruction: Who are the authors of this study?

Output: Keith DS, Nichols GA, Gullion CM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who are the authors of this study?. ### Response: Keith DS, Nichols GA, Gullion CM.


Instruction: What is the name of the disease that affects men with blood pressure?

Output: end-stagerenal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease that affects men with blood pressure?. ### Response: end-stagerenal.


Instruction: When was the N Engl J Med 334 published?

Output: 1996

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the N Engl J Med 334 published?. ### Response: 1996.


Instruction: How old were the patients treated for hypertension?

Output: 80 years of age or older

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old were the patients treated for hypertension?. ### Response: 80 years of age or older.


Instruction: What is the name of the group that studies the prevention of stroke by antihypertension?

Output: SHEP Cooperative Research Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that studies the prevention of stroke by antihypertension?. ### Response: SHEP Cooperative Research Group.


Instruction: What are the names of the groups that study the effects of different regimens to lower blood pressure on major cardiovascular events in older and youngeradults?

Output: Turnbull F, Neal B, Ninomiya T et al. Effects of different regimens to lowerblood pressure on major cardiovascular events in older and youngeradults: meta-analysis of randomised trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the groups that study the effects of different regimens to lower blood pressure on major cardiovascular events in older and youngeradults?. ### Response: Turnbull F, Neal B, Ninomiya T et al. Effects of different regimens to lowerblood pressure on major cardiovascular events in older and youngeradults: meta-analysis of randomised trials.


Instruction: What year was e390 Stroke December 20192?

Output: For prevention of recurrent stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was e390 Stroke December 20192?. ### Response: For prevention of recurrent stroke.


Instruction: What is reasonable in some patients with AIS for prevention of recurrent stroke?

Output: the use of intracranial vessel imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable in some patients with AIS for prevention of recurrent stroke?. ### Response: the use of intracranial vessel imaging.


Instruction: What did not yield adequate data to identify subgroups of patients with AIS for whom information obtained from intracranial vessel imaging will lead to improved outcome?

Output: An extensive literature search

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did not yield adequate data to identify subgroups of patients with AIS for whom information obtained from intracranial vessel imaging will lead to improved outcome?. ### Response: An extensive literature search.


Instruction: There is no RCT evidence that patients with what type of AIS should be treated differently from other patients?

Output: AIS and symptomatic intracranial stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is no RCT evidence that patients with what type of AIS should be treated differently from other patients?. ### Response: AIS and symptomatic intracranial stenosis.


Instruction: What should be treated differently from other patients with ischemic stroke of presumed atherosclerotic cause?

Output: patients with AIS and symptomatic intracranial stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be treated differently from other patients with ischemic stroke of presumed atherosclerotic cause?. ### Response: patients with AIS and symptomatic intracranial stenosis.


Instruction: What did the WASID RCT provide no benefit over aspirin 325 mg/d?

Output: warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the WASID RCT provide no benefit over aspirin 325 mg/d?. ### Response: warfarin.


Instruction: The SAMMPRIS trial did not provide any benefit over what?

Output: intracranial arterial stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The SAMMPRIS trial did not provide any benefit over what?. ### Response: intracranial arterial stenosis.


Instruction: What did the SAMMPRIS trial show no benefit of adding Wingspan stenting to?

Output: aggressive medical therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the SAMMPRIS trial show no benefit of adding Wingspan stenting to?. ### Response: aggressive medical therapy.


Instruction: How long after enrollment did aspirin and clopidogrel last?

Output: 90 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after enrollment did aspirin and clopidogrel last?. ### Response: 90 days.


Instruction: What did the CHANCE trial compare with clopidogrel and aspirin for 21 days?

Output: dual antiplatelet treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the CHANCE trial compare with clopidogrel and aspirin for 21 days?. ### Response: dual antiplatelet treatment.


Instruction: What was not shown in the CHance trial in patients with high-risk TIA and minor stroke?

Output: preferential benefit from dual antiplatelet treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not shown in the CHance trial in patients with high-risk TIA and minor stroke?. ### Response: preferential benefit from dual antiplatelet treatment.


Instruction: How long after enrollment did antithrombotics last?

Output: 131

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after enrollment did antithrombotics last?. ### Response: 131.


Instruction: What did high-risk TIA and minor stroke show no evidence of in patients with intracranial arterial stenosis?

Output: preferential benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did high-risk TIA and minor stroke show no evidence of in patients with intracranial arterial stenosis?. ### Response: preferential benefit.


Instruction: What did the medical treatment-only group in SAMMPRIS have an almost 2-fold lower risk of within 30 days?

Output: any stroke or death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the medical treatment-only group in SAMMPRIS have an almost 2-fold lower risk of within 30 days?. ### Response: any stroke or death.


Instruction: How long did aspirin and clopidogrel last?

Output: 90 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did aspirin and clopidogrel last?. ### Response: 90 days.


Instruction: What is the risk of a stroke within 30 days?

Output: 2-fold lower risk of any stroke or death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of a stroke within 30 days?. ### Response: 2-fold lower risk of any stroke or death.


Instruction: How many days did a ischemic stroke occur within the territory of the qualifying artery?

Output: 30 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many days did a ischemic stroke occur within the territory of the qualifying artery?. ### Response: 30 days.


Instruction: How can imaging of the intracranial vasculature detect atherosclerotic stenosis of a major artery be demonstrated?

Output: echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can imaging of the intracranial vasculature detect atherosclerotic stenosis of a major artery be demonstrated?. ### Response: echocardiography.


Instruction: How many RCTs have evaluated mechanical closure of echocardiographically detected PFO to prevent recurrent stroke in patients without obvious cause for their index stroke?

Output: Six

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs have evaluated mechanical closure of echocardiographically detected PFO to prevent recurrent stroke in patients without obvious cause for their index stroke?. ### Response: Six.


Instruction: What was the eligibility criteria for these trials?

Output: highly restrictive

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the eligibility criteria for these trials?. ### Response: highly restrictive.


Instruction: What was required to be included in the criteria?

Output: brain MRI, imaging of the intracranial vasculature, and echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was required to be included in the criteria?. ### Response: brain MRI, imaging of the intracranial vasculature, and echocardiography.


Instruction: Meta-analyses of these trials show a significantly reduced risk of recurrent stroke?

Output: mechanical closure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Meta-analyses of these trials show a significantly reduced risk of recurrent stroke?. ### Response: mechanical closure.


Instruction: What is the number needed to treat?

Output: 131

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the number needed to treat?. ### Response: 131.


Instruction: How old are patients with PFO closure?

Output: <60 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old are patients with PFO closure?. ### Response: <60 years of age.


Instruction: What type of therapy is used?

Output: medical therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is used?. ### Response: medical therapy.


Instruction: What is the term for atrial high rate episodes?

Output: AHRE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for atrial high rate episodes?. ### Response: AHRE.


Instruction: What is AHRE?

Output: atrial high-rate episodes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is AHRE?. ### Response: atrial high-rate episodes.


Instruction: How long is a CIED?

Output: 5 min duration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is a CIED?. ### Response: 5 min duration.


Instruction: What is AF?

Output: symptomatic or asymptomatic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is AF?. ### Response: symptomatic or asymptomatic.


Instruction: What is indicated in patients with CIED-detected AHRE?

Output: continued patient follow-up

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is indicated in patients with CIED-detected AHRE?. ### Response: continued patient follow-up.


Instruction: How is a complete cardiological evaluation indicated?

Output: 12-lead ECG, general assessment of clinical conditions,and clinical risk strati ﬁcation for stroke usingCHA2DS2-VASc score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is a complete cardiological evaluation indicated?. ### Response: 12-lead ECG, general assessment of clinical conditions,and clinical risk strati ﬁcation for stroke usingCHA2DS2-VASc score.


Instruction: What is there no evidence in support or against prescribing of oral anticoagulants in patients at risk of stroke?

Output: Remark :

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is there no evidence in support or against prescribing of oral anticoagulants in patients at risk of stroke?. ### Response: Remark :.


Instruction: What does AHREs correspond to?

Output: atrial tachyarrhythmias/AF atelectrograms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does AHREs correspond to?. ### Response: atrial tachyarrhythmias/AF atelectrograms.


Instruction: What do we suggest in patients with AF?

Output: prescription oforal anticoagulants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do we suggest in patients with AF?. ### Response: prescription oforal anticoagulants.


Instruction: What does individualizedclinical assessment take into account?

Output: overallAHRE burden

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does individualizedclinical assessment take into account?. ### Response: overallAHRE burden.


Instruction: How does CHA 2DS2-VASc measure stroke risk?

Output: intermediate to high risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does CHA 2DS2-VASc measure stroke risk?. ### Response: intermediate to high risk.


Instruction: What is used to predict the risk/benefit of oral anticoagulation?

Output: individual stroke risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used to predict the risk/benefit of oral anticoagulation?. ### Response: individual stroke risk.


Instruction: What is the ungraded consensus-based statement?

Output: CHA2DS2VASc-score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ungraded consensus-based statement?. ### Response: CHA2DS2VASc-score.


Instruction: In patients with CIED-detected AHRE,continued patient follow-up is recommended?

Output: acomplete cardiological evaluation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with CIED-detected AHRE,continued patient follow-up is recommended?. ### Response: acomplete cardiological evaluation.


Instruction: What is the purpose of CIED follow-up?

Output: evaluating if AHRE >24 h and/or clinical AFdevelops

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of CIED follow-up?. ### Response: evaluating if AHRE >24 h and/or clinical AFdevelops.


Instruction: How long does AHRE or AF burden last?

Output: more than 24 h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does AHRE or AF burden last?. ### Response: more than 24 h.


Instruction: What can a change in clinical pro file or clinicalconditions suggest?

Output: any clinical change

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can a change in clinical pro file or clinicalconditions suggest?. ### Response: any clinical change.


Instruction: What would suggest a change in clinical pro file or clinicalconditions?

Output: clinical change

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would suggest a change in clinical pro file or clinicalconditions?. ### Response: clinical change.


Instruction: What is a patient with a CIED, no previous AF and detection of AHRE (5-6 min and>180 beats/min) evaluated?

Output: Detection of AHRE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a patient with a CIED, no previous AF and detection of AHRE (5-6 min and>180 beats/min) evaluated?. ### Response: Detection of AHRE.


Instruction: What is the CHA2DS2VASc-score?

Output: Clinical risk stratification for stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the CHA2DS2VASc-score?. ### Response: Clinical risk stratification for stroke.


Instruction: What is a clinical risk stratification for stroke?

Output: CHA2DS2VASc-score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a clinical risk stratification for stroke?. ### Response: CHA2DS2VASc-score.


Instruction: How many lead ECGIf diagnoses are there?

Output: 12

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many lead ECGIf diagnoses are there?. ### Response: 12.


Instruction: What is the CHA2DS2VASc score in malesand 3 in females?

Output: ≥2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the CHA2DS2VASc score in malesand 3 in females?. ### Response: ≥2.


Instruction: What is advised for monitoring AHRE evolution?

Output: remote monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is advised for monitoring AHRE evolution?. ### Response: remote monitoring.


Instruction: What is an example of a change in patient status/clinical profile?

Output: heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a change in patient status/clinical profile?. ### Response: heart failure.


Instruction: What are individual considerations for prescription of OAC considering?

Output: overall

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are individual considerations for prescription of OAC considering?. ### Response: overall.


Instruction: What is the name of the European Society of Cardiology?

Output: ESC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the European Society of Cardiology?. ### Response: ESC.


Instruction: When did the Eur Heart J issue 32(24):3147-3197.418?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Eur Heart J issue 32(24):3147-3197.418?. ### Response: 2011.


Instruction: What is atrial fibrillation inpregnancy a growing challenge?

Output: Diseases during Pregnancy of the European Society of Cardiology(ESC). Eur Heart J . 2011;32(24):3147-3197 .418. Katsi V, Georgiopoulos G, Marketou M, et al. Atrial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is atrial fibrillation inpregnancy a growing challenge?. ### Response: Diseases during Pregnancy of the European Society of Cardiology(ESC). Eur Heart J . 2011;32(24):3147-3197 .418. Katsi V, Georgiopoulos G, Marketou M, et al. Atrial.


Instruction: What is the name of the study that compares hypertensive heart failure of pregnancy with peripartum cardiomyopathy?

Output: PloS One

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that compares hypertensive heart failure of pregnancy with peripartum cardiomyopathy?. ### Response: PloS One.


Instruction: What is a population-based study of atrial fibrillation?

Output: J Am Heart Assoc

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a population-based study of atrial fibrillation?. ### Response: J Am Heart Assoc.


Instruction: Atrial flutter in pregnant women: a population-based study?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atrial flutter in pregnant women: a population-based study?. ### Response: —.


Instruction: What is the name of the 9th ed: American College of Chest PhysiciansEvidence-Based Clinical Practice Guidelines?

Output: antithrombotic therapy, andpregnancy: Antithrombotic Therapy and Prevention ofThrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 9th ed: American College of Chest PhysiciansEvidence-Based Clinical Practice Guidelines?. ### Response: antithrombotic therapy, andpregnancy: Antithrombotic Therapy and Prevention ofThrombosis.


Instruction: What are PhysiciansEvidence-Based Clinical Practice Guidelines?

Output: American College of Chest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are PhysiciansEvidence-Based Clinical Practice Guidelines?. ### Response: American College of Chest.


Instruction: What are the 2012 Chest 141(2Suppl):e691S-e736S.422.

Output: antithrombotic therapy, andpregnancy: Antithrombotic Therapy and Prevention ofThrombosis, 9th ed: American College of Chest PhysiciansEvidence-Based Clinical Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the 2012 Chest 141(2Suppl):e691S-e736S.422.. ### Response: antithrombotic therapy, andpregnancy: Antithrombotic Therapy and Prevention ofThrombosis, 9th ed: American College of Chest PhysiciansEvidence-Based Clinical Practice Guidelines.


Instruction: What is the 2012 Cardiol Clin.30(3):395-405?

Output: Anticoagulation in pregnancy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2012 Cardiol Clin.30(3):395-405?. ### Response: Anticoagulation in pregnancy.


Instruction: What is acenocoumarol?

Output: breast feed theirinfants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is acenocoumarol?. ### Response: breast feed theirinfants.


Instruction: What is warfarin sodium contraindicatedin for lactating mothers?

Output: breast-feed their infants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is warfarin sodium contraindicatedin for lactating mothers?. ### Response: breast-feed their infants.


Instruction: When did J Pediatr 1983 103(2):325-327?

Output: 1983

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J Pediatr 1983 103(2):325-327?. ### Response: 1983.


Instruction: What is the effect of acenocoumarol on the breast-fed infant?

Output: breast feed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of acenocoumarol on the breast-fed infant?. ### Response: breast feed.


Instruction: What was the name of the disease inpatients with chronic kidney disease?

Output: atrial ﬁbrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the disease inpatients with chronic kidney disease?. ### Response: atrial ﬁbrillation.


Instruction: Who was the author of Thrombosis Res?

Output: Fondevila

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the author of Thrombosis Res?. ### Response: Fondevila.


Instruction: Who endorsed the European Heart Rhythm Association's clinical signi ficance and implications for decision making?

Output: the Heart Rhythm Society and the Asia Paci ﬁc HeartRhythm Society

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who endorsed the European Heart Rhythm Association's clinical signi ficance and implications for decision making?. ### Response: the Heart Rhythm Society and the Asia Paci ﬁc HeartRhythm Society.


Instruction: What does the Paci fic HeartRhythm Society do?

Output: endorsed by the Heart Rhythm Society and the Asia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Paci fic HeartRhythm Society do?. ### Response: endorsed by the Heart Rhythm Society and the Asia.


Instruction: What does Warfarin utilisation andanticoagulation control do in patients with atrial fibrillation andchronic kidney disease?

Output: breast-feed their infants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Warfarin utilisation andanticoagulation control do in patients with atrial fibrillation andchronic kidney disease?. ### Response: breast-feed their infants.


Instruction: How many(11):818-826.430 are Existing Risk Scores for?

Output: 103

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many(11):818-826.430 are Existing Risk Scores for?. ### Response: 103.


Instruction: Is Existing Risk Scores for Nonvalvular Atrial Fibrillation Useful for Prediction or RiskAdjustment in Patients With Chronic Kidney Disease?

Output: Are Existing Risk Scores forNonvalvular Atrial Fibrillation Useful

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Is Existing Risk Scores for Nonvalvular Atrial Fibrillation Useful for Prediction or RiskAdjustment in Patients With Chronic Kidney Disease?. ### Response: Are Existing Risk Scores forNonvalvular Atrial Fibrillation Useful.


Instruction: Can JCardiol. 2017;33(2):243-252.431.

Output: al. Are Existing Risk Scores forNonvalvular Atrial Fibrillation Useful for Prediction or RiskAdjustment in Patients With Chronic Kidney Disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Can JCardiol. 2017;33(2):243-252.431.. ### Response: al. Are Existing Risk Scores forNonvalvular Atrial Fibrillation Useful for Prediction or RiskAdjustment in Patients With Chronic Kidney Disease.


Instruction: Incidence and prediction of ischemic stroke among atrial fibrillation patients with end-stagerenal disease requiring dialysis.

Output: ischemic stroke among atrial ﬁbrillation patients with end-stagerenal disease requiring dialysis. Heart Rhythm . 2014;11(10):1752-1759 .432

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Incidence and prediction of ischemic stroke among atrial fibrillation patients with end-stagerenal disease requiring dialysis.. ### Response: ischemic stroke among atrial ﬁbrillation patients with end-stagerenal disease requiring dialysis. Heart Rhythm . 2014;11(10):1752-1759 .432.


Instruction: What is end-stage renal disease requiring dialysis?

Output: ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is end-stage renal disease requiring dialysis?. ### Response: ischemic stroke.


Instruction: What is the name of the journal that studies kidneydysfunction and warfarin in patients with atrial fibrillation?

Output: Jama

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies kidneydysfunction and warfarin in patients with atrial fibrillation?. ### Response: Jama.


Instruction: What did the guidelinepanel consider the extent of resource use associated with?

Output: alternative management options

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the guidelinepanel consider the extent of resource use associated with?. ### Response: alternative management options.


Instruction: On what basis did the panel agree on direction and strength recommendations?

Output: consensus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On what basis did the panel agree on direction and strength recommendations?. ### Response: consensus.


Instruction: Who reviewed and approved the final recommendations of the panel?

Output: All panel members

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who reviewed and approved the final recommendations of the panel?. ### Response: All panel members.


Instruction: How are recommendations labeled?

Output: “strong ”or“condi-tional

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are recommendations labeled?. ### Response: “strong ”or“condi-tional.


Instruction: What are the recommendations labeled as either "strong" or "condi-tional" according to the GRADE approach?

Output: Interpretation of strong andconditional recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the recommendations labeled as either "strong" or "condi-tional" according to the GRADE approach?. ### Response: Interpretation of strong andconditional recommendations.


Instruction: The words "the guidelinepanel recommends"are used for what?

Output: strong recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The words "the guidelinepanel recommends"are used for what?. ### Response: strong recommendations.


Instruction: What type of recommendations were made by patients, clinicians, and health care policy makers?

Output: strongand conditional

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of recommendations were made by patients, clinicians, and health care policy makers?. ### Response: strongand conditional.


Instruction: When were the draft recommendations made available online?

Output: 5 December 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When were the draft recommendations made available online?. ### Response: 5 December 2017.


Instruction: How many individuals or organizations submitted comments to the document?

Output: Ten

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many individuals or organizations submitted comments to the document?. ### Response: Ten.


Instruction: When did the ASH GuidelineOversight Subcommittee and ASH Committee on Quality approve that the defined guideline development process was followed?

Output: 30 June 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the ASH GuidelineOversight Subcommittee and ASH Committee on Quality approve that the defined guideline development process was followed?. ### Response: 30 June 2018.


Instruction: Who approved submission of the guidelines for publication?

Output: the officers of the ASH ExecutiveCommittee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who approved submission of the guidelines for publication?. ### Response: the officers of the ASH ExecutiveCommittee.


Instruction: Who reviewed the guidelines?

Output: Blood Advances

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who reviewed the guidelines?. ### Response: Blood Advances.


Instruction: What are the guidelines primarily intended to help clinicians make?

Output: ecisions about diagnostic and treatment alternatives

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the guidelines primarily intended to help clinicians make?. ### Response: ecisions about diagnostic and treatment alternatives.


Instruction: What are other purposes of the guidelines?

Output: to inform policy, education, and advocacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are other purposes of the guidelines?. ### Response: to inform policy, education, and advocacy.


Instruction: What are the guidelines not intended to serve or be construed as?

Output: astandard of care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the guidelines not intended to serve or be construed as?. ### Response: astandard of care.