Instruction: What can be helpful in patients with initially nondiagnostic findings?

Output: Transthoracic echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be helpful in patients with initially nondiagnostic findings?. ### Response: Transthoracic echocardiography.


Instruction: Treatment includes maintenance of what?

Output: RV preload

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Treatment includes maintenance of what?. ### Response: RV preload.


Instruction: Nitrates and what else should be avoided?

Output: diuretics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Nitrates and what else should be avoided?. ### Response: diuretics.


Instruction: What should be avoided?

Output: Nitrates and diuretics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be avoided?. ### Response: Nitrates and diuretics.


Instruction: What may be needed to restore atrioventricular synchrony or cardioversion from AF?

Output: Nitrates and diuretics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be needed to restore atrioventricular synchrony or cardioversion from AF?. ### Response: Nitrates and diuretics.


Instruction: What indicates the possibility of ventricle septal rupture or mitral regurgitation?

Output: The presence of a new systolic murmur

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates the possibility of ventricle septal rupture or mitral regurgitation?. ### Response: The presence of a new systolic murmur.


Instruction: What should be obtained when a mechanical defect is sus-pected?

Output: Surgical con-sultation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be obtained when a mechanical defect is sus-pected?. ### Response: Surgical con-sultation.


Instruction: Prompt repair is indicated in most cases with or without what?

Output: CABG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Prompt repair is indicated in most cases with or without what?. ### Response: CABG.


Instruction: What is indicated in most cases?

Output: Prompt repair

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is indicated in most cases?. ### Response: Prompt repair.


Instruction: What can provide temporary circulatory support?

Output: IABP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can provide temporary circulatory support?. ### Response: IABP.


Instruction: How does mitral regurgitation after STEMI occur?

Output: via 1 of 2 mecha-nisms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does mitral regurgitation after STEMI occur?. ### Response: via 1 of 2 mecha-nisms.


Instruction: Acute rupture affects what?

Output: posteromedial papillary muscle

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Acute rupture affects what?. ### Response: posteromedial papillary muscle.


Instruction: Acute rupture affects the posteromedial papillary muscle more often than what other muscle?

Output: anterolateral papillary muscle

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Acute rupture affects the posteromedial papillary muscle more often than what other muscle?. ### Response: anterolateral papillary muscle.


Instruction: Acute severe mitral regurgitation is characterized by pulmo-nary edema and/or what?

Output: shock

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Acute severe mitral regurgitation is characterized by pulmo-nary edema and/or what?. ### Response: shock.


Instruction: What should be considered for urgent surgery while temporary stabilization with medical therapy and IABP is attempted?

Output: Suitable patients with papillary muscle rup-ture

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered for urgent surgery while temporary stabilization with medical therapy and IABP is attempted?. ### Response: Suitable patients with papillary muscle rup-ture.


Instruction: Emergency mitral valve replacement rather than repair usually is required in what setting?

Output: urgent surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Emergency mitral valve replacement rather than repair usually is required in what setting?. ### Response: urgent surgery.


Instruction: What is associated with an extremely high mortality rate?

Output: RV InfarctionRV infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with an extremely high mortality rate?. ### Response: RV InfarctionRV infarction.


Instruction: What is the mortality rate associated with valve replacement?

Output: 20%),

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the mortality rate associated with valve replacement?. ### Response: 20%),.


Instruction: What is improved with surgery com-pared with medical therapy alone?

Output: sur -vival and ventricular function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is improved with surgery com-pared with medical therapy alone?. ### Response: sur -vival and ventricular function.


Instruction: Delay to operation appears to increase the risk of what?

Output: myocardial injury, organ failure, and death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Delay to operation appears to increase the risk of what?. ### Response: myocardial injury, organ failure, and death.


Instruction: Five-year survival rates after surgery average how much?

Output: 60% to 70%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Five-year survival rates after surgery average how much?. ### Response: 60% to 70%..


Instruction: What are the five-year survival rates after surgery?

Output: 60% to 70%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the five-year survival rates after surgery?. ### Response: 60% to 70%..


Instruction: What is the term for ischemic (functional) mitral regurgitation?

Output: STEMI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for ischemic (functional) mitral regurgitation?. ### Response: STEMI.


Instruction: What is a factor that may support the choice of repeat CABG?

Output: vessels unsuitable for PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a factor that may support the choice of repeat CABG?. ### Response: vessels unsuitable for PCI.


Instruction: What is the internalmammaryartery for grafting chronically occluded coronaryarteries?

Output: availability of the internalmammary artery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the internalmammaryartery for grafting chronically occluded coronaryarteries?. ### Response: availability of the internalmammary artery.


Instruction: What is the main difference between management of the patient withSIHD and the bypass graft placement?

Output: the impetusfor revascularization is stronger

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the main difference between management of the patient withSIHD and the bypass graft placement?. ### Response: the impetusfor revascularization is stronger.


Instruction: What are factors favoring PCI over CABG?

Output: limited areas ofischemia causing symptoms, suitable PCI targets, a patentgraft to the LAD artery, poor CABG targets, and comorbidconditions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are factors favoring PCI over CABG?. ### Response: limited areas ofischemia causing symptoms, suitable PCI targets, a patentgraft to the LAD artery, poor CABG targets, and comorbidconditions.


Instruction: How is a patentgraft to the LAD artery done?

Output: PCI with coronary stenting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is a patentgraft to the LAD artery done?. ### Response: PCI with coronary stenting.


Instruction: What is the main difference between management of SIHD and UA/NSTEMI?

Output: the impetusfor revascularization is stronger

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the main difference between management of SIHD and UA/NSTEMI?. ### Response: the impetusfor revascularization is stronger.


Instruction: Why is myocardial ischemia occurring as part of ACS potentially life threatening?

Output: revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is myocardial ischemia occurring as part of ACS potentially life threatening?. ### Response: revascularization.


Instruction: What is more likely to be reduced with a revascularization procedure?

Output: anginalsymptoms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more likely to be reduced with a revascularization procedure?. ### Response: anginalsymptoms.


Instruction: What is more likely to be reduced with a revascular-ization procedure than with GDMT?

Output: myocardial ischemia occurring as part ofan ACS is potentially life threatening, and associated anginalsymptoms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more likely to be reduced with a revascular-ization procedure than with GDMT?. ### Response: myocardial ischemia occurring as part ofan ACS is potentially life threatening, and associated anginalsymptoms.


Instruction: What are the indica-tions for re-vascularization strengthened by?

Output: acuity ofpresentation, the extent of ischemia, and the ability to achievefull revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the indica-tions for re-vascularization strengthened by?. ### Response: acuity ofpresentation, the extent of ischemia, and the ability to achievefull revascularization.


Instruction: The choice of revas-tion method is generally dictated by what considerations?

Output: the same considerations used todecide on PCI or CABG for patients with SIHD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The choice of revas-tion method is generally dictated by what considerations?. ### Response: the same considerations used todecide on PCI or CABG for patients with SIHD.


Instruction: What should not be performed if the patient is not likely to be able to tolerate and comply with DAPT for the appropri-ate duration?

Output: PCI with coronary stenting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not be performed if the patient is not likely to be able to tolerate and comply with DAPT for the appropri-ate duration?. ### Response: PCI with coronary stenting.


Instruction: What are the same considerations used todecide on PCI or CABG?

Output: limited areas ofischemia causing symptoms, suitable PCI targets, a patentgraft to the LAD artery, poor CABG targets, and comorbidconditions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the same considerations used todecide on PCI or CABG?. ### Response: limited areas ofischemia causing symptoms, suitable PCI targets, a patentgraft to the LAD artery, poor CABG targets, and comorbidconditions.


Instruction: What is the risk of stent thrombosis increased dramatically inpatients who prematurely discontinue DAPT?

Output: mortality rate of 20% to45%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of stent thrombosis increased dramatically inpatients who prematurely discontinue DAPT?. ### Response: mortality rate of 20% to45%..


Instruction: What is associated with a mortality rate of 20% to45%?

Output: stentthrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with a mortality rate of 20% to45%?. ### Response: stentthrombosis.


Instruction: What is the mortality rate of DESpatients?

Output: 85,88–91,93,204

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the mortality rate of DESpatients?. ### Response: 85,88–91,93,204.


Instruction: How long is the recommended minimum duration of DAPT therapy?

Output: 14 to 30 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the recommended minimum duration of DAPT therapy?. ### Response: 14 to 30 days.


Instruction: Why is it recommended to treat DES patients for at least 12 months?

Output: to avoid late (after30 days) stent thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is it recommended to treat DES patients for at least 12 months?. ### Response: to avoid late (after30 days) stent thrombosis.


Instruction: How long does it take to avoid late stent thrombosis?

Output: after30 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take to avoid late stent thrombosis?. ### Response: after30 days.


Instruction: What is an important consideration in deciding whether to use PCI?

Output: limited areas ofischemia causing symptoms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an important consideration in deciding whether to use PCI?. ### Response: limited areas ofischemia causing symptoms.


Instruction: How long is it necessary for the patient to tolerate and comply with DAPT?

Output: 30 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is it necessary for the patient to tolerate and comply with DAPT?. ### Response: 30 days.


Instruction: What is an important consideration in deciding whether to use PCI to treat patients with CAD?

Output: ability of thepatient to tolerate and comply with at least 30 days of DAPTwith BMS treatment and at least 12 months of DAPT withDES treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an important consideration in deciding whether to use PCI to treat patients with CAD?. ### Response: ability of thepatient to tolerate and comply with at least 30 days of DAPTwith BMS treatment and at least 12 months of DAPT withDES treatment.


Instruction: What has been used on occasion in patients with severeangina refractory to GDMT in whom complete revascularization cannot be achieved?

Output: TMR as an Adjunct to CABGTMR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been used on occasion in patients with severeangina refractory to GDMT in whom complete revascularization cannot be achieved?. ### Response: TMR as an Adjunct to CABGTMR.


Instruction: PCI and/or CABG are two options for what?

Output: patients with SIHD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: PCI and/or CABG are two options for what?. ### Response: patients with SIHD.


Instruction: What is the mechanism by which TMR might be efficacious in these patients?

Output: unknown

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the mechanism by which TMR might be efficacious in these patients?. ### Response: unknown.


Instruction: How many RCTs of TMR as soletherapy demonstrated a reduction in anginal symptoms compared with intensive medical therapy alone?

Output: 213,214

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs of TMR as soletherapy demonstrated a reduction in anginal symptoms compared with intensive medical therapy alone?. ### Response: 213,214.


Instruction: What is the clinical practice guideline for screening and management of high blood pressure in childrenand adolescents?

Output: BP Measurement in clinical practice: time to SPRINTto guideline-recommended protocols

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the clinical practice guideline for screening and management of high blood pressure in childrenand adolescents?. ### Response: BP Measurement in clinical practice: time to SPRINTto guideline-recommended protocols.


Instruction: What is a report of the ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA?

Output: Guideline for the prevention,detection, evaluation, and management of high blood pressure inadults: a report of the American College of Cardiology/American HeartAssociation Task Force on Clinical Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a report of the ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA?. ### Response: Guideline for the prevention,detection, evaluation, and management of high blood pressure inadults: a report of the American College of Cardiology/American HeartAssociation Task Force on Clinical Practice Guidelines.


Instruction: What did the American College of Cardiology/American HeartAssociation Task Force on Clinical Practice Guidelines do?

Output: prevention,detection, evaluation, and management of high blood pressure inadults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the American College of Cardiology/American HeartAssociation Task Force on Clinical Practice Guidelines do?. ### Response: prevention,detection, evaluation, and management of high blood pressure inadults.


Instruction: What is the name of the group that did a report on the management of high blood pressure inadults?

Output: American College of Cardiology/American HeartAssociation Task Force on Clinical Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that did a report on the management of high blood pressure inadults?. ### Response: American College of Cardiology/American HeartAssociation Task Force on Clinical Practice Guidelines.


Instruction: What is a scienti fic statement from the American Heart Association?

Output: Measurement of blood pressure inhumans

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a scienti fic statement from the American Heart Association?. ### Response: Measurement of blood pressure inhumans.


Instruction: What is an acronym for?

Output: American HeartAssociation Task Force on Clinical Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an acronym for?. ### Response: American HeartAssociation Task Force on Clinical Practice Guidelines.


Instruction: How often is sphygmomanometer calibration?

Output: why,how and how often

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often is sphygmomanometer calibration?. ### Response: why,how and how often.


Instruction: What is the 2019 ACC/AHA guideline on primary prevention of cardiovascular disease?

Output: executive summary:a report of the American College of Cardiology/American HeartAssociation Task Force on Clinical Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2019 ACC/AHA guideline on primary prevention of cardiovascular disease?. ### Response: executive summary:a report of the American College of Cardiology/American HeartAssociation Task Force on Clinical Practice Guidelines.


Instruction: What is the primary prevention of cardiovascular disease?

Output: ACC/AHA guideline onthe primary prevention of cardiovascular disease: executive summary:a report of the American College of Cardiology/American HeartAssociation Task Force on Clinical Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary prevention of cardiovascular disease?. ### Response: ACC/AHA guideline onthe primary prevention of cardiovascular disease: executive summary:a report of the American College of Cardiology/American HeartAssociation Task Force on Clinical Practice Guidelines.


Instruction: What is a report of the American College of Cardiology/American HeartAssociation Task Force?

Output: Clinical Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a report of the American College of Cardiology/American HeartAssociation Task Force?. ### Response: Clinical Practice Guidelines.


Instruction: What is the task force for themanagement of arterial hypertension of the European Society ofCardiology?

Output: ESC/ESH guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the task force for themanagement of arterial hypertension of the European Society ofCardiology?. ### Response: ESC/ESH guidelines.


Instruction: What does Horswill MS do?

Output: resting blood pressure in clinicalsettings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Horswill MS do?. ### Response: resting blood pressure in clinicalsettings.


Instruction: What is the name of the systematic review of adult patients'resting blood pressure in clinicalsettings: a systematic review?

Output: J Hypertens

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review of adult patients'resting blood pressure in clinicalsettings: a systematic review?. ### Response: J Hypertens.


Instruction: When did Drawz PE, Ix JH. BP Measurement in clinical practice: time to SPRINTto guideline-recommended protocols?

Output: 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Drawz PE, Ix JH. BP Measurement in clinical practice: time to SPRINTto guideline-recommended protocols?. ### Response: 2018.


Instruction: What did ONTARGET Investigators, Yusuf S, Teo KK, et al. study?

Output: Telmisartan, ram

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did ONTARGET Investigators, Yusuf S, Teo KK, et al. study?. ### Response: Telmisartan, ram.


Instruction: What does lowering blood pressure reduce in type 2 diabetes?

Output: renal events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does lowering blood pressure reduce in type 2 diabetes?. ### Response: renal events.


Instruction: What is the name of the drug used in patients at high risk for vascular events?

Output: Telmisartan, ramipril

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used in patients at high risk for vascular events?. ### Response: Telmisartan, ramipril.


Instruction: When was the N Engl J Med published?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the N Engl J Med published?. ### Response: 2008.


Instruction: What is SPS3?

Output: SmallSubcortical Strokes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SPS3?. ### Response: SmallSubcortical Strokes.


Instruction: What is the name of the post hoc analysis of the secondary prevention of SmallSubcortical Strokes (SPS3) Randomized Trial?

Output: Effect of intensive versus usualblood pressure control on kidney function among individuals with priorlacunar stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the post hoc analysis of the secondary prevention of SmallSubcortical Strokes (SPS3) Randomized Trial?. ### Response: Effect of intensive versus usualblood pressure control on kidney function among individuals with priorlacunar stroke.


Instruction: What is the name of the Randomized Trial?

Output: SmallSubcortical Strokes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Randomized Trial?. ### Response: SmallSubcortical Strokes.


Instruction: What are the names of the two blood pressure measurement methods used in children?

Output: Oscillometric and auscultatory

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the two blood pressure measurement methods used in children?. ### Response: Oscillometric and auscultatory.


Instruction: What may cause prothrombotic effects?

Output: aspirin and by COX-2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may cause prothrombotic effects?. ### Response: aspirin and by COX-2.


Instruction: Why should enteric-coated aspirin be avoided?

Output: its delayed and reduced absorption

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why should enteric-coated aspirin be avoided?. ### Response: its delayed and reduced absorption.


Instruction: What should be avoided initially because of its delayed and reduced absorption?

Output: Enteric-coated aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be avoided initially because of its delayed and reduced absorption?. ### Response: Enteric-coated aspirin.


Instruction: See Section 5.1.2.1 for recommendations at the time of what?

Output: PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: See Section 5.1.2.1 for recommendations at the time of what?. ### Response: PCI.


Instruction: What is the recommended maintenance dose of aspirin to be used with ticagrelor?

Output: 81 mg daily

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommended maintenance dose of aspirin to be used with ticagrelor?. ### Response: 81 mg daily.


Instruction: What is the name of the study that examined midlife vascular risk factors and late-life mild cognitive impairment?

Output: population-based study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined midlife vascular risk factors and late-life mild cognitive impairment?. ### Response: population-based study.


Instruction: What was the population-based study?

Output: Midlife vascular risk factors and late-life mild cognitive impairment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the population-based study?. ### Response: Midlife vascular risk factors and late-life mild cognitive impairment.


Instruction: How many people were involved in the Cardiovascular Health Cognition Study?

Output: 3301

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were involved in the Cardiovascular Health Cognition Study?. ### Response: 3301.


Instruction: What is vascular dementia in the Cardiovascular Health Cognition Study?

Output: Determinants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is vascular dementia in the Cardiovascular Health Cognition Study?. ### Response: Determinants.


Instruction: What is the name of the study that studies the presence and severity of cerebral white matter lesions and hypertension, its treatment and its con-trol?

Output: The ARIC Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that studies the presence and severity of cerebral white matter lesions and hypertension, its treatment and its con-trol?. ### Response: The ARIC Study.


Instruction: How many elderly people were studied in the Communities Study?

Output: 3301

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many elderly people were studied in the Communities Study?. ### Response: 3301.


Instruction: What is the name of the study that examined white matter findings on cranial magnetic resonance imaging of 3301 elderly people?

Output: The Cardiovascular Health Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined white matter findings on cranial magnetic resonance imaging of 3301 elderly people?. ### Response: The Cardiovascular Health Study.


Instruction: Which study examined the association between aortic stiffening and microvascular disease in brain and heart?

Output: opril Protection Against Recurrent Stroke Study trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which study examined the association between aortic stiffening and microvascular disease in brain and heart?. ### Response: opril Protection Against Recurrent Stroke Study trial.


Instruction: What is the relationship between aortic stiffening and microvascular disease in brain and kidney?

Output: cause and logic of therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the relationship between aortic stiffening and microvascular disease in brain and kidney?. ### Response: cause and logic of therapy.


Instruction: Hypertension. 2005;46:200-4. S11.3-15. Skoog I. A review on what?

Output: blood pressure and ischaemic white matter lesions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hypertension. 2005;46:200-4. S11.3-15. Skoog I. A review on what?. ### Response: blood pressure and ischaemic white matter lesions.


Instruction: Dement Geriatr Cogn Disord. 1998;9(suppl 1):13-9.

Output: S11.3-16

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Dement Geriatr Cogn Disord. 1998;9(suppl 1):13-9.. ### Response: S11.3-16.


Instruction: What role does hypertension play in cognitive function?

Output: current evidence and challenges for the future

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What role does hypertension play in cognitive function?. ### Response: current evidence and challenges for the future.


Instruction: What is the name of the study that compares placebo and active treatment for older patients with hypertension?

Output: The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that compares placebo and active treatment for older patients with hypertension?. ### Response: The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators.


Instruction: What is the name of the Systolic Hypertension in Europe Trial Investigators?

Output: Syst-Eur

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Systolic Hypertension in Europe Trial Investigators?. ### Response: Syst-Eur.


Instruction: When did the Lancet issue 350:757-64?

Output: 1997

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Lancet issue 350:757-64?. ### Response: 1997.


Instruction: What did the Perindopril Protection Against Recurrent Stroke Study trial do?

Output: Impact of blood pres-sure lowering on cardiovascular outcomes in normal weight, over -weight, and obese individuals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Perindopril Protection Against Recurrent Stroke Study trial do?. ### Response: Impact of blood pres-sure lowering on cardiovascular outcomes in normal weight, over -weight, and obese individuals.


Instruction: Perindopril Protection Against Recurrent Stroke Study trial. Hypertension. 2010;55:1193–8. S11.3-19. Bosch J, Yusuf S, Pogue J, et al. Use of ramipril in preventing stroke: double blind randomised trial.

Output: Impact of blood pres-sure lowering on cardiovascular outcomes in normal weight, over -weight, and obese individuals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Perindopril Protection Against Recurrent Stroke Study trial. Hypertension. 2010;55:1193–8. S11.3-19. Bosch J, Yusuf S, Pogue J, et al. Use of ramipril in preventing stroke: double blind randomised trial.. ### Response: Impact of blood pres-sure lowering on cardiovascular outcomes in normal weight, over -weight, and obese individuals.


Instruction: What is type 2 diabetes mellitus?

Output: Cognitive function and brain structure in persons with type 2 diabetes mellitus after intensive lowering of blood pressure and lipid levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is type 2 diabetes mellitus?. ### Response: Cognitive function and brain structure in persons with type 2 diabetes mellitus after intensive lowering of blood pressure and lipid levels.


Instruction: What is the effect of lowering blood pressure and lipid levels on cognitive function?

Output: brain structure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of lowering blood pressure and lipid levels on cognitive function?. ### Response: brain structure.


Instruction: What did the ONTARGET and TRANSCEND studies look at?

Output: Renin-angiotensin system block-ade and cognitive function in patients at high risk of cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the ONTARGET and TRANSCEND studies look at?. ### Response: Renin-angiotensin system block-ade and cognitive function in patients at high risk of cardiovascular disease.


Instruction: When did the Lancet Neurol. 2011:10:43-53?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Lancet Neurol. 2011:10:43-53?. ### Response: 2011.


Instruction: What was the effect of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan?

Output: disability and cognitive function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the effect of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan?. ### Response: disability and cognitive function.


Instruction: What is the name of the double-blind, active and placebo-controlled trial?

Output: Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the double-blind, active and placebo-controlled trial?. ### Response: Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial.


Instruction: What does PRoFESS stand for?

Output: Prevention Regimen for Effectively Avoiding Second Strokes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does PRoFESS stand for?. ### Response: Prevention Regimen for Effectively Avoiding Second Strokes.


Instruction: What prevents smooth muscle cellmigration?

Output: internal elastic lamina

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What prevents smooth muscle cellmigration?. ### Response: internal elastic lamina.


Instruction: What is the disadvantage of using the IMA?

Output: it may spasmand eventually atrophy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the disadvantage of using the IMA?. ### Response: it may spasmand eventually atrophy.


Instruction: What is a disadvantage of using an IMA?

Output: it may spasmand eventually atrophy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a disadvantage of using an IMA?. ### Response: it may spasmand eventually atrophy.


Instruction: What is the advantage of using the LIMA instead of an SVG?

Output: survival benefit is independentof the patient’s sex, age, extent of CAD, and LV systolicfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the advantage of using the LIMA instead of an SVG?. ### Response: survival benefit is independentof the patient’s sex, age, extent of CAD, and LV systolicfunction.


Instruction: What is used to graft the LAD artery86-88?

Output: LIMA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used to graft the LAD artery86-88?. ### Response: LIMA.


Instruction: What is the survival benefit independent of?

Output: the patient’s sex, age, extent of CAD, and LV systolicfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the survival benefit independent of?. ### Response: the patient’s sex, age, extent of CAD, and LV systolicfunction.


Instruction: Apart from improving survival rate, what reduces the incidence of late MI?

Output: LIMAgrafting of the LAD artery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Apart from improving survival rate, what reduces the incidence of late MI?. ### Response: LIMAgrafting of the LAD artery.


Instruction: What should be used to bypass the LAD artery if a contraindication to its use is not present?

Output: The LIMA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be used to bypass the LAD artery if a contraindication to its use is not present?. ### Response: The LIMA.


Instruction: What is the beneficial influence of using the IMA for grafting?

Output: morbidity andmortality rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the beneficial influence of using the IMA for grafting?. ### Response: morbidity andmortality rates.


Instruction: What have several centers advocated in hopes of further improving CABG results?

Output: bilateral IMA grafting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have several centers advocated in hopes of further improving CABG results?. ### Response: bilateral IMA grafting.


Instruction: Numerous studies have demonstrated improved morbidity and mortality rates when both IMAs are used?

Output: observa-tional

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Numerous studies have demonstrated improved morbidity and mortality rates when both IMAs are used?. ### Response: observa-tional.


Instruction: Bilateral IMA grafting appears to be associated with what?

Output: anincreased incidence of sternal wound infections

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Bilateral IMA grafting appears to be associated with what?. ### Response: anincreased incidence of sternal wound infections.


Instruction: What is associated with an increased incidence of sternal wound infections in diabetes mellitus patients and those who are obese?

Output: bilateral IMA grafting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with an increased incidence of sternal wound infections in diabetes mellitus patients and those who are obese?. ### Response: bilateral IMA grafting.


Instruction: What is the body mass index/H1102230 kg/m2?

Output: obese

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the body mass index/H1102230 kg/m2?. ### Response: obese.


Instruction: What has been used to improve the results of CABG?

Output: bilateral IMA grafting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been used to improve the results of CABG?. ### Response: bilateral IMA grafting.


Instruction: What is sparse in comparison to what is known about IMAs?

Output: arterial conduits

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is sparse in comparison to what is known about IMAs?. ### Response: arterial conduits.


Instruction: What is a muscular artery that is susceptible to spasm and atrophy?

Output: The radial artery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a muscular artery that is susceptible to spasm and atrophy?. ### Response: The radial artery.


Instruction: What is best when used to graft a left-sided coronary artery with /H1102270% stenosis?

Output: Radial artery graft patency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is best when used to graft a left-sided coronary artery with /H1102270% stenosis?. ### Response: Radial artery graft patency.


Instruction: What type of artery is most commonly used to bypass the right coronary artery or its branches?

Output: gastroepiploic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of artery is most commonly used to bypass the right coronary artery or its branches?. ### Response: gastroepiploic.


Instruction: The gastroepiploic artery may also be usedto bypass what?

Output: the LAD artery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The gastroepiploic artery may also be usedto bypass what?. ### Response: the LAD artery.


Instruction: What can be used to bypass the LAD artery?

Output: gastroepiploic artery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be used to bypass the LAD artery?. ### Response: gastroepiploic artery.


Instruction: What is similar to the radial artery in that it is prone tospasm?

Output: gastroepiploic artery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is similar to the radial artery in that it is prone tospasm?. ### Response: gastroepiploic artery.


Instruction: How long is thepatency rate of the gastroepiploic artery reported?

Output: 91%,80%, and 62%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is thepatency rate of the gastroepiploic artery reported?. ### Response: 91%,80%, and 62%,.


Instruction: How long is the patency rate of the gastroepiploic artery?

Output: 91%,80%, and 62%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the patency rate of the gastroepiploic artery?. ### Response: 91%,80%, and 62%,.


Instruction: What are the reportedly 91%,80%, and 62%patency rates?

Output: 131The 1-, 5-, and 10-yearpatency rates of the gastroepiploic artery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the reportedly 91%,80%, and 62%patency rates?. ### Response: 131The 1-, 5-, and 10-yearpatency rates of the gastroepiploic artery.


Instruction: 134–137 These studies use a variety of methods to induce what?

Output: hypothermia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: 134–137 These studies use a variety of methods to induce what?. ### Response: hypothermia.


Instruction: A large phase III trial of hypothermia in what is ongoing?

Output: AIS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A large phase III trial of hypothermia in what is ongoing?. ### Response: AIS.


Instruction: When was XXXIV in online Data Supplement 1 downloaded from http://ahajournals.org?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was XXXIV in online Data Supplement 1 downloaded from http://ahajournals.org?. ### Response: April 28, 2023.


Instruction: What is the name of the document that was downloaded from http://ahajournals.org by on April 28, 2023?

Output: Disclosures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the document that was downloaded from http://ahajournals.org by on April 28, 2023?. ### Response: Disclosures.


Instruction: Who is a member of the DisclosuresWriting Group?

Output: EmploymentResearchGrantOther Research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a member of the DisclosuresWriting Group?. ### Response: EmploymentResearchGrantOther Research.


Instruction: What is the name of the University of California, San Francisco?

Output: Ann Bolger

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the University of California, San Francisco?. ### Response: Ann Bolger.


Instruction: Who works at the Mayo Clinic?

Output: Walter Wilson Mayo Clinic None None None None None NoneLarry M. Baddour

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who works at the Mayo Clinic?. ### Response: Walter Wilson Mayo Clinic None None None None None NoneLarry M. Baddour.


Instruction: Who is the head of Northwestern University Feinberg School of Medicine?

Output: Robert O. Bonow

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the head of Northwestern University Feinberg School of Medicine?. ### Response: Robert O. Bonow.


Instruction: Who manufactures medical devices and diagnostics?

Output: David T. Durack Becton Dickinson & Co

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who manufactures medical devices and diagnostics?. ### Response: David T. Durack Becton Dickinson & Co.


Instruction: Who is a member of the Joint CommissionResources Board?

Output: Patricia Ferrieri University of Minnesota Medical School

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a member of the Joint CommissionResources Board?. ### Response: Patricia Ferrieri University of Minnesota Medical School.


Instruction: What is the name of the Cincinnati Children’s Hospital Medical Center?

Output: Michael Gerber

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Cincinnati Children’s Hospital Medical Center?. ### Response: Michael Gerber.


Instruction: What school of medicine is David Goff affiliated with?

Output: Wake Forest University School of Medicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What school of medicine is David Goff affiliated with?. ### Response: Wake Forest University School of Medicine.


Instruction: What is the name of the law firm that represents patients at Wake Forest University School of Medicine?

Output: Spriggs & HollingsworthLaw Firm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the law firm that represents patients at Wake Forest University School of Medicine?. ### Response: Spriggs & HollingsworthLaw Firm.


Instruction: Who is the founder of the Boston Children’s Heart Foundation?

Output: Jane W. Newburger

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the founder of the Boston Children’s Heart Foundation?. ### Response: Jane W. Newburger.


Instruction: What is another name for ScientificEvidence Consulting Firm?

Output: Spriggs & HollingsworthLaw Firm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for ScientificEvidence Consulting Firm?. ### Response: Spriggs & HollingsworthLaw Firm.


Instruction: What is the name of the hospital that treats children with endocarditis?

Output: Anne H. Rowley Children’s Memorial Hospital

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the hospital that treats children with endocarditis?. ### Response: Anne H. Rowley Children’s Memorial Hospital.


Instruction: Where is Stanford T. Shulman Children's Memorial Hospital located?

Output: Chicago

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Stanford T. Shulman Children's Memorial Hospital located?. ### Response: Chicago.


Instruction: What is the name of the school of medicine at the University of Pennsylvania School of Medicine?

Output: Pfizer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the school of medicine at the University of Pennsylvania School of Medicine?. ### Response: Pfizer.


Instruction: What is the name of the medical imaging company in Southern California?

Output: Bristol-Myers Squibb

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the medical imaging company in Southern California?. ### Response: Bristol-Myers Squibb.


Instruction: Where is the University of Utah School of Medicine?

Output: University of Southern California

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the University of Utah School of Medicine?. ### Response: University of Southern California.


Instruction: Who is the president of American Heart Association?

Output: Kathryn A. Taubert

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the president of American Heart Association?. ### Response: Kathryn A. Taubert.


Instruction: What is required of all members of the writing group to complete and submit?

Output: Disclosure Questionnaire

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is required of all members of the writing group to complete and submit?. ### Response: Disclosure Questionnaire.


Instruction: What is a relationship considered to be?

Output: Significan t

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a relationship considered to be?. ### Response: Significan t.


Instruction: What month was Hypertension June 20188.1.2?

Output: e40

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What month was Hypertension June 20188.1.2?. ### Response: e40.


Instruction: What are the recommendations for BP Treatment Threshold and Use of Risk Estimation* to Guide Drug Treatment of Hypertension summarized in?

Output: Online Data Supplement 23

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the recommendations for BP Treatment Threshold and Use of Risk Estimation* to Guide Drug Treatment of Hypertension summarized in?. ### Response: Online Data Supplement 23.


Instruction: What is BP-lowering medication recommended for secondary prevention of?

Output: recurrent CVD events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is BP-lowering medication recommended for secondary prevention of?. ### Response: recurrent CVD events.


Instruction: What is an average SBP of 130 mm Hg or higher?

Output: 80

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an average SBP of 130 mm Hg or higher?. ### Response: 80.


Instruction: What is an average DBP of 80 mm Hg or higher?

Output: 130

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an average DBP of 80 mm Hg or higher?. ### Response: 130.


Instruction: What is used for primary prevention in adults with an estimated 10-year atherosclerotic cardiovascular disease risk?

Output: BP-lowering medications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used for primary prevention in adults with an estimated 10-year atherosclerotic cardiovascular disease risk?. ### Response: BP-lowering medications.


Instruction: What is the SBP of an adult with no history of CVD?

Output: 140 mm Hg or higher or a DBP of 90 mm Hg or higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the SBP of an adult with no history of CVD?. ### Response: 140 mm Hg or higher or a DBP of 90 mm Hg or higher.


Instruction: What is BP-lowering medication recommended for?

Output: primary prevention  of CVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is BP-lowering medication recommended for?. ### Response: primary prevention  of CVD.


Instruction: How long is the ASCVD risk 10%?

Output: 10-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the ASCVD risk 10%?. ### Response: 10-year.


Instruction: What is a DBP of 90 mm Hg or higher?

Output: Hg or higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a DBP of 90 mm Hg or higher?. ### Response: Hg or higher.


Instruction: What is the 10-year risk of atherosclerotic CVD?

Output: 10% or higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 10-year risk of atherosclerotic CVD?. ### Response: 10% or higher.


Instruction: How was ASCVD defined?

Output: a first CHD death, non-fatal MI or fatal or non-fatal stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was ASCVD defined?. ### Response: a first CHD death, non-fatal MI or fatal or non-fatal stroke.


Instruction: What is more efficient and cost effective at reducing risk of CVD than use of BP alone?

Output: use of a combination of absolute CVD risk and BP level

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more efficient and cost effective at reducing risk of CVD than use of BP alone?. ### Response: use of a combination of absolute CVD risk and BP level.


Instruction: What is used to guide treatment of high BP?

Output: absolute CVD risk and BP level

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used to guide treatment of high BP?. ### Response: absolute CVD risk and BP level.


Instruction: What has been developed to translate evidence from RCTs into individual patient treat-ment recommendations?

Output: Practical approaches

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been developed to translate evidence from RCTs into individual patient treat-ment recommendations?. ### Response: Practical approaches.


Instruction: What do several national and international guidelines recommend basing use of?

Output: BP-lowering medica-tions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do several national and international guidelines recommend basing use of?. ### Response: BP-lowering medica-tions.


Instruction: What do national and international guidelines recommend basing use of BP-lowering medica-tions on?

Output: a combination of absolute risk of CVD and level of BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do national and international guidelines recommend basing use of BP-lowering medica-tions on?. ### Response: a combination of absolute risk of CVD and level of BP.


Instruction: What have tried to use absolute risk to guide implementation of pharmacological treatment?

Output: mixed results

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have tried to use absolute risk to guide implementation of pharmacological treatment?. ### Response: mixed results.


Instruction: What have been mixed results to prevent CVD?

Output: many reports of improvements in pro-vider prescribing behaviors, patient adherence, and reduc-tions in risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have been mixed results to prevent CVD?. ### Response: many reports of improvements in pro-vider prescribing behaviors, patient adherence, and reduc-tions in risk.


Instruction: What are some reports showing no impact on provider behaviors?

Output: S8.1.2-32–S8.1.2-38

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some reports showing no impact on provider behaviors?. ### Response: S8.1.2-32–S8.1.2-38.


Instruction: Use of global CVD risk assess-ment is infrequent in what?

Output: routine clinical practice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Use of global CVD risk assess-ment is infrequent in what?. ### Response: routine clinical practice.


Instruction: What does routine clinical practice suggest would be required to achieve universal implementation?

Output: intensive efforts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does routine clinical practice suggest would be required to achieve universal implementation?. ### Response: intensive efforts.


Instruction: What has been an important source of variability, ambiguity, and controversy?

Output: The choice of specific risk calculators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been an important source of variability, ambiguity, and controversy?. ### Response: The choice of specific risk calculators.


Instruction: What would result from implementing a standard absolute CVD risk threshold for initiating use of BP-lowering medications?

Output: large variations in medication

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would result from implementing a standard absolute CVD risk threshold for initiating use of BP-lowering medications?. ### Response: large variations in medication.


Instruction: Who is the Director of the Evidence Review Team?

Output: Jonathan C. Craig

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Director of the Evidence Review Team?. ### Response: Jonathan C. Craig.


Instruction: What is the title of the Associate Project Director?

Output: Assistant Project Director

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of the Associate Project Director?. ### Response: Assistant Project Director.


Instruction: Who is a co-director of the Evidence Review Team?

Output: Suetonia C. Palmer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a co-director of the Evidence Review Team?. ### Response: Suetonia C. Palmer.


Instruction: Who is the Managing Editor of Cochrane Kidney and Transplant?

Output: Gail Y. Higgins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Managing Editor of Cochrane Kidney and Transplant?. ### Response: Gail Y. Higgins.


Instruction: What is the MSc in Evidence-based Health Care?

Output: Research Associate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the MSc in Evidence-based Health Care?. ### Response: Research Associate.


Instruction: Who is a Research Associate of the guideline?

Output: Nicole Evangelidis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a Research Associate of the guideline?. ### Response: Nicole Evangelidis.


Instruction: What are the names of the authors who have updated their reviews?

Output: Elisabeth Hodson, Emma McMahon, Patrizia Natale,Narelle Willis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the authors who have updated their reviews?. ### Response: Elisabeth Hodson, Emma McMahon, Patrizia Natale,Narelle Willis.


Instruction: Who has updated their reviews for this guideline?

Output: Elisabeth Hodson, Emma McMahon, Patrizia Natale,Narelle Willis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who has updated their reviews for this guideline?. ### Response: Elisabeth Hodson, Emma McMahon, Patrizia Natale,Narelle Willis.


Instruction: What is the name of the person who has updated his reviews?

Output: Elisabeth Hodson, Emma McMahon, Patrizia Natale,Narelle Willis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the person who has updated his reviews?. ### Response: Elisabeth Hodson, Emma McMahon, Patrizia Natale,Narelle Willis.


Instruction: Who is a member of the Work Group?

Output: MAGICAPP LIAISON

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a member of the Work Group?. ### Response: MAGICAPP LIAISON.


Instruction: How many disability-adjusted life-years were associated with IE in 2010?

Output: 1.58 mil-lion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many disability-adjusted life-years were associated with IE in 2010?. ### Response: 1.58 mil-lion.


Instruction: Who conducted epidemiological surveys on IE?

Output: France and the International Collaboration on Endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who conducted epidemiological surveys on IE?. ### Response: France and the International Collaboration on Endocarditis.


Instruction: How many years of healthy life were lost as a result of death and impairment?

Output: 1.58 mil-lion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many years of healthy life were lost as a result of death and impairment?. ### Response: 1.58 mil-lion.


Instruction: What has the epide-miological profile of IE changed substantially?

Output: increased mean patient age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has the epide-miological profile of IE changed substantially?. ### Response: increased mean patient age.


Instruction: What is the most common causative organism in most cases?

Output: S aureus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common causative organism in most cases?. ### Response: S aureus.


Instruction: What is the most common causative organism in most of the industrialized world?

Output: S aureus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common causative organism in most of the industrialized world?. ### Response: S aureus.


Instruction: Why is the emergence of S aureus IE due in part to the increasing importance of healthcare contact as a leading risk associated with infection?

Output: ylococcus aureus has increased, and S aureus is now the most common causative organism in most of the industrialized world

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is the emergence of S aureus IE due in part to the increasing importance of healthcare contact as a leading risk associated with infection?. ### Response: ylococcus aureus has increased, and S aureus is now the most common causative organism in most of the industrialized world.


Instruction: Characteristics of IE patients have also shifted toward what?

Output: an increased mean patient age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Characteristics of IE patients have also shifted toward what?. ### Response: an increased mean patient age.


Instruction: IE patients have shifted toward an increased mean patient age, a higher proportion of prosthetic valves, and a decreasing proportion of what?

Output: rheumatic heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: IE patients have shifted toward an increased mean patient age, a higher proportion of prosthetic valves, and a decreasing proportion of what?. ### Response: rheumatic heart disease.


Instruction: What has increased over time to reach 50%?

Output: IE patients undergoing surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has increased over time to reach 50%?. ### Response: IE patients undergoing surgery.


Instruction: When was the last iteration of the AHA statement on diagnosis and management of IE complications published?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last iteration of the AHA statement on diagnosis and management of IE complications published?. ### Response: 2005.


Instruction: When was IE complications published?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was IE complications published?. ### Response: 2005.


Instruction: What has validated the rapid detection of pathogens from valve tissue from patients undergoing surgery for IE?

Output: polymerase chain reaction (PCR)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has validated the rapid detection of pathogens from valve tissue from patients undergoing surgery for IE?. ### Response: polymerase chain reaction (PCR).


Instruction: How have diagnostic inno-vations emerged?

Output: through new imaging techniques

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How have diagnostic inno-vations emerged?. ### Response: through new imaging techniques.


Instruction: What are three dimensions of echocardiography?

Output: 3D

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are three dimensions of echocardiography?. ### Response: 3D.


Instruction: What is a head-to-toe multislice computed tomography called?

Output: CT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a head-to-toe multislice computed tomography called?. ### Response: CT.


Instruction: Several risk stratification models for quantifying morbidity and mortality in IE patients have been developed and validated.

Output: In addi-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Several risk stratification models for quantifying morbidity and mortality in IE patients have been developed and validated.. ### Response: In addi-tion.


Instruction: Daptomycin has been evaluated in the treatment of what?

Output: S aureus bacteremia and IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Daptomycin has been evaluated in the treatment of what?. ### Response: S aureus bacteremia and IE.


Instruction: How many studies have examined the impact and timing of valve surgery in IE management?

Output: Several rigorously conducted observational studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies have examined the impact and timing of valve surgery in IE management?. ### Response: Several rigorously conducted observational studies.


Instruction: What has been published in addition to updated international management guidelines?

Output: valve surgery in IE management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been published in addition to updated international management guidelines?. ### Response: valve surgery in IE management.


Instruction: What did the Committee do to update the previous version of the guidelines?

Output: conducted com-prehensive and focused reviews of the literature

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Committee do to update the previous version of the guidelines?. ### Response: conducted com-prehensive and focused reviews of the literature.


Instruction: What databases were used to identify pertinent articles?

Output: PubMed/MEDLINE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What databases were used to identify pertinent articles?. ### Response: PubMed/MEDLINE.


Instruction: In what language were the searches limited?

Output: English

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what language were the searches limited?. ### Response: English.


Instruction: What language was used to search for endocarditis?

Output: English

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What language was used to search for endocarditis?. ### Response: English.


Instruction: What were the major search terms for?

Output: endocarditis, infective endocardi-

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the major search terms for?. ### Response: endocarditis, infective endocardi-.


Instruction: How long is fondaparinux for the duration of hospitalization or until PCI is performed2.5 mg SC dailyI B 312–314

Output: 310, 311

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is fondaparinux for the duration of hospitalization or until PCI is performed2.5 mg SC dailyI B 312–314. ### Response: 310, 311.


Instruction: How long is IV UFH?

Output: 48 h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is IV UFH?. ### Response: 48 h.


Instruction: What is the initial loading dose?

Output: 60 IU/kg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the initial loading dose?. ### Response: 60 IU/kg.


Instruction: How many IU/kg/h is the first infusion?

Output: 12

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many IU/kg/h is the first infusion?. ### Response: 12.


Instruction: When is IV fibrinolytic treatment not recommended?

Output: patients with NSTE-ACS N/A III

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is IV fibrinolytic treatment not recommended?. ### Response: patients with NSTE-ACS N/A III.


Instruction: What is not recommended in patients with NSTE-ACS N/A III: Harm A 93, 329?

Output: IV fibrinolytic treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended in patients with NSTE-ACS N/A III: Harm A 93, 329?. ### Response: IV fibrinolytic treatment.


Instruction: What is the recommended maintenance dose of aspirin to be used with ticagrelor?

Output: 81 mg daily

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommended maintenance dose of aspirin to be used with ticagrelor?. ### Response: 81 mg daily.


Instruction: What is the daily dose of aspirin to be used with ticagrelor?

Output: 81 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the daily dose of aspirin to be used with ticagrelor?. ### Response: 81 mg.


Instruction: What indicates activated partial thromboplastin time?

Output: 290aPTT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates activated partial thromboplastin time?. ### Response: 290aPTT.


Instruction: BID, twice daily; COR, Class of Recommendation; CrCl, creatinine clearance; IV, intravenous; Level of Evidence; max, maximum; N/A, not available.

Output: 290aPTT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: BID, twice daily; COR, Class of Recommendation; CrCl, creatinine clearance; IV, intravenous; Level of Evidence; max, maximum; N/A, not available.. ### Response: 290aPTT.


Instruction: What is NSTE-ACS?

Output: non-ST-elevation acute coronary syndromes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NSTE-ACS?. ### Response: non-ST-elevation acute coronary syndromes.


Instruction: What is PCI?

Output: percutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PCI?. ### Response: percutaneous coronary intervention.


Instruction: Where is UFH available?

Output: unfractionated heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is UFH available?. ### Response: unfractionated heparin.


Instruction: When was this article published?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this article published?. ### Response: April 28, 2023.


Instruction: Section 3.3 provides recommendations on who should perform surgeries, cardiac catheterization, and other procedures in patients?

Output: cardiologist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Section 3.3 provides recommendations on who should perform surgeries, cardiac catheterization, and other procedures in patients?. ### Response: cardiologist.


Instruction: Section 3.4 provides rec-ommendations on what?

Output: diagnostic evaluation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Section 3.4 provides rec-ommendations on what?. ### Response: diagnostic evaluation.


Instruction: Table 18 provides routine testing and what else?

Output: follow-up intervals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Table 18 provides routine testing and what else?. ### Response: follow-up intervals.


Instruction: Exercise stress testing may be reasonable in the assessment of exercise capacity, what type of stress-induced stress?

Output: arrhythmias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Exercise stress testing may be reasonable in the assessment of exercise capacity, what type of stress-induced stress?. ### Response: arrhythmias.


Instruction: What may be considered as an adjunct to echocar -diographic imaging?

Output: Exercise stress testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered as an adjunct to echocar -diographic imaging?. ### Response: Exercise stress testing.


Instruction: What should patients with symptomatic subAS achieve from surgical relief of the obstruction?

Output: symptomatic improvement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients with symptomatic subAS achieve from surgical relief of the obstruction?. ### Response: symptomatic improvement.


Instruction: In some cases, what may be needed?

Output: concomitant AVR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In some cases, what may be needed?. ### Response: concomitant AVR.


Instruction: What may be needed in some cases?

Output: concomitant AVR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be needed in some cases?. ### Response: concomitant AVR.


Instruction: Patients with depressed LV systolic function and severe subAS may not manifest a resting gradient of 50 mm Hg.

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with depressed LV systolic function and severe subAS may not manifest a resting gradient of 50 mm Hg.. ### Response: 3.


Instruction: How can surgical relief of LVOT obstruction be extrapolated from the existing aortic stenosis data?

Output: as per the 2014 VHD guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can surgical relief of LVOT obstruction be extrapolated from the existing aortic stenosis data?. ### Response: as per the 2014 VHD guideline.


Instruction: What should be considered as per the 2014 VHD guideline?

Output: evaluation and decisions regarding surgical relief of LVOT obstruc-tion can be extrapolated from the existing aortic stenosis data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered as per the 2014 VHD guideline?. ### Response: evaluation and decisions regarding surgical relief of LVOT obstruc-tion can be extrapolated from the existing aortic stenosis data.


Instruction: In addition, patients Table 17. Congenital Mitral Stenosis: Routine Follow-Up and Testing IntervalsWhat is the frequency of routine follow-up and testing?

Output: Frequency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In addition, patients Table 17. Congenital Mitral Stenosis: Routine Follow-Up and Testing IntervalsWhat is the frequency of routine follow-up and testing?. ### Response: Frequency.


Instruction: What is the name of the outpatient ACHD cardiologist?

Output: Outpatient ACHD cardiologist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the outpatient ACHD cardiologist?. ### Response: Outpatient ACHD cardiologist.


Instruction: How long is the ACHD classification system?

Output: 24 24 6–12 3–6ECG 24 24 12 12TTE 24 24 12 12Exercise test† As needed 24 24 12

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the ACHD classification system?. ### Response: 24 24 6–12 3–6ECG 24 24 12 12TTE 24 24 12 12Exercise test† As needed 24 24 12.


Instruction: How long is the ACHD AP classification system?

Output: 24 24 6–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the ACHD AP classification system?. ### Response: 24 24 6–.


Instruction: What does ACHD indicate?

Output: adult congenital heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ACHD indicate?. ### Response: adult congenital heart disease.


Instruction: How long does the CPET take?

Output: 6-minute

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does the CPET take?. ### Response: 6-minute.


Instruction: What is NICE 2018's title for Chronic Heart Failure?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE 2018's title for Chronic Heart Failure?. ### Response: ©.


Instruction: What is the ISBN number for Table 135: Summary of Evidence for Contact / Access?

Output: 978 -1-4731 -3093 -7 379

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ISBN number for Table 135: Summary of Evidence for Contact / Access?. ### Response: 978 -1-4731 -3093 -7 379.


Instruction: How many studies contributed to the finding Design Criteria Rating Overall assessment of confidence 4a Access to Routine Care 3126#2749,207 2 x secondary analysis of what?

Output: pt interviews

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies contributed to the finding Design Criteria Rating Overall assessment of confidence 4a Access to Routine Care 3126#2749,207 2 x secondary analysis of what?. ### Response: pt interviews.


Instruction: What did people with heart failure find difficult to stand up for themselves?

Output: the illness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did people with heart failure find difficult to stand up for themselves?. ### Response: the illness.


Instruction: What did the illness make it harder for them to do?

Output: stand up for themselves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the illness make it harder for them to do?. ### Response: stand up for themselves.


Instruction: Who interviewed people who wanted continued access, a new referral or re-referral?

Output: HCP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who interviewed people who wanted continued access, a new referral or re-referral?. ### Response: HCP.


Instruction: What is harder to stand up for themselves?

Output: the illness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is harder to stand up for themselves?. ### Response: the illness.


Instruction: What is LOW Coherence no or very minor concerns?

Output: Relevance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is LOW Coherence no or very minor concerns?. ### Response: Relevance.


Instruction: A Primary Contact Person 1 29 Interviews with pt People with heart failure expressed a preference for what?

Output: a primary contact person

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A Primary Contact Person 1 29 Interviews with pt People with heart failure expressed a preference for what?. ### Response: a primary contact person.


Instruction: Interviews with pt People with heart failure expressed a preference for a primary contact person who offered a long-term relationship, openness, trust and appreciation?

Output: GP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Interviews with pt People with heart failure expressed a preference for a primary contact person who offered a long-term relationship, openness, trust and appreciation?. ### Response: GP.


Instruction: Most would choose their GP who would provide easy access to care, e.g. timely appointments?

Output: heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Most would choose their GP who would provide easy access to care, e.g. timely appointments?. ### Response: heart failure.


Instruction: To provide easy access to care, e.g. timely appointments?

Output: GP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: To provide easy access to care, e.g. timely appointments?. ### Response: GP.


Instruction: Coherence no or very minor concerns Relevance serious concerns Adequacy moderate concerns 4c Access to Urgent Care

Output: moderate limitations  VERY LOW

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Coherence no or very minor concerns Relevance serious concerns Adequacy moderate concerns 4c Access to Urgent Care. ### Response: moderate limitations  VERY LOW.


Instruction: Interviews with pt 60 and over and carer What was noted about people with hea rt failure that were under the care of HF clinics and nurses?

Output: they had easy access to specialist doctors and nurses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Interviews with pt 60 and over and carer What was noted about people with hea rt failure that were under the care of HF clinics and nurses?. ### Response: they had easy access to specialist doctors and nurses.


Instruction: What was the problem with specialist doctors and nurses?

Output: could not provide continuity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the problem with specialist doctors and nurses?. ### Response: could not provide continuity.


Instruction: What were the limitations of the methodology?

Output: moderate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the limitations of the methodology?. ### Response: moderate.


Instruction: What type of concerns are moderately significant?

Output: Adequacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of concerns are moderately significant?. ### Response: Adequacy.


Instruction: What is a moderate concern moderate concern?

Output: Adequacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a moderate concern moderate concern?. ### Response: Adequacy.


Instruction: How many studies contributed to the finding Design Criteria Rating Overall assessment of confidence 5a Expectations

Output: No of studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies contributed to the finding Design Criteria Rating Overall assessment of confidence 5a Expectations. ### Response: No of studies.


Instruction: What was associated with a significantly increased risk of major or life-threatening bleeding?

Output: dual ther -apy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with a significantly increased risk of major or life-threatening bleeding?. ### Response: dual ther -apy.


Instruction: When was Circulation. 2021;143:e72–e227?

Output: February 2, 2021

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Circulation. 2021;143:e72–e227?. ### Response: February 2, 2021.


Instruction: How many patients were included in a systematic review and meta-analysis?

Output: 2500

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were included in a systematic review and meta-analysis?. ### Response: 2500.


Instruction: What is the risk of major or life-threatening bleeding associated with sin-gle-agent therapy?

Output: fewer 30-day deaths and less major bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of major or life-threatening bleeding associated with sin-gle-agent therapy?. ### Response: fewer 30-day deaths and less major bleeding.


Instruction: What is the risk of thromboembolism per year in patients with biological valves in sinus rhythm?

Output: 0.7%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of thromboembolism per year in patients with biological valves in sinus rhythm?. ### Response: 0.7%.


Instruction: What is Figure 13 derived from several studies in which most patients were not undergoing therapy with VKA?

Output: thromboembolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Figure 13 derived from several studies in which most patients were not undergoing therapy with VKA?. ### Response: thromboembolism.


Instruction: What are the rates of thromboembolism among patients with bio-prosthetic valves?

Output: 0.7% per year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the rates of thromboembolism among patients with bio-prosthetic valves?. ### Response: 0.7% per year.


Instruction: What is the rate per patient-year for patients with a mitral prosthesis versus an aortic prosthesis?

Output: 2.4% per patient-year versus 1.9%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the rate per patient-year for patients with a mitral prosthesis versus an aortic prosthesis?. ### Response: 2.4% per patient-year versus 1.9%.


Instruction: What did the patients who received aspirin receive?

Output: 75–100 mg daily

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the patients who received aspirin receive?. ### Response: 75–100 mg daily.


Instruction: What was the outcome of the antiplatelet agents in the patients with bioprosthetics?

Output: bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome of the antiplatelet agents in the patients with bioprosthetics?. ### Response: bleeding.


Instruction: What are the long-term effects of antiplatelet agents in patients with bioprosthetic mitral valve repair?

Output: There are no studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the long-term effects of antiplatelet agents in patients with bioprosthetic mitral valve repair?. ### Response: There are no studies.


Instruction: The beneficial effects seen with what type of valve may apply?

Output: oprosthetic aortic valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The beneficial effects seen with what type of valve may apply?. ### Response: oprosthetic aortic valves.


Instruction: Many patients who undergo surgical implantation will not require what?

Output: lifelong anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Many patients who undergo surgical implantation will not require what?. ### Response: lifelong anticoagulation.


Instruction: What will not require lifelong anticoagulation in the absence of an independent indication, such as AF?

Output: Many patients who undergo surgical implantation of a bioprosthetic mitral or aortic valve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will not require lifelong anticoagulation in the absence of an independent indication, such as AF?. ### Response: Many patients who undergo surgical implantation of a bioprosthetic mitral or aortic valve.