Instruction: What is a term for acute decompensated heart failure?

Output: ADHF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a term for acute decompensated heart failure?. ### Response: ADHF.


Instruction: In what year was the Am J Cardiol published?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was the Am J Cardiol published?. ### Response: 2006.


Instruction: What is used for the diagnosis of heart failure in the emergency department?

Output: BNP and NT-proBNP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used for the diagnosis of heart failure in the emergency department?. ### Response: BNP and NT-proBNP.


Instruction: What is the name of the systematic review of the evidence for the use of BNP and NT-proBNP?

Output: Heart Fail

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review of the evidence for the use of BNP and NT-proBNP?. ### Response: Heart Fail.


Instruction: What is the determinant and detection of left ventricular dysfunction in the gener -al community?

Output: Amino-terminal pro-B-type natriuretic peptide and B-type natriuretic peptide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the determinant and detection of left ventricular dysfunction in the gener -al community?. ### Response: Amino-terminal pro-B-type natriuretic peptide and B-type natriuretic peptide.


Instruction: What is de Lemos JA, McGuire DK, Khera A, et al?

Output: 32

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is de Lemos JA, McGuire DK, Khera A, et al?. ### Response: 32.


Instruction: What did the Dallas Heart Study do?

Output: Screening the population for left ventricular hypertrophy and left ventricular systolic dysfunction us-ing natriuretic peptides

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Dallas Heart Study do?. ### Response: Screening the population for left ventricular hypertrophy and left ventricular systolic dysfunction us-ing natriuretic peptides.


Instruction: What did Goetze JP, Mogelvang R, Maage L, et al. screen for?

Output: left ventricular hypertro-phy and systolic dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Goetze JP, Mogelvang R, Maage L, et al. screen for?. ### Response: left ventricular hypertro-phy and systolic dysfunction.


Instruction: What is screening for left ventricular hypertro-phy and systolic dysfunction?

Output: Plasma pro-B-type natriuretic peptide in the general population

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is screening for left ventricular hypertro-phy and systolic dysfunction?. ### Response: Plasma pro-B-type natriuretic peptide in the general population.


Instruction: What is natriuretic peptide in the general population?

Output: Plasma pro-B-type

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is natriuretic peptide in the general population?. ### Response: Plasma pro-B-type.


Instruction: When did Eur Heart J. 2006 release 27:3004-10?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Eur Heart J. 2006 release 27:3004-10?. ### Response: 2006.


Instruction: What is a marker of cardiac fibrosis that pre-dicts incident heart failure in the community?

Output: Galectin-3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a marker of cardiac fibrosis that pre-dicts incident heart failure in the community?. ### Response: Galectin-3.


Instruction: What is Galectin-3?

Output: a marker of cardiac fibrosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Galectin-3?. ### Response: a marker of cardiac fibrosis.


Instruction: When did J Am Coll Cardiol. 2012 issue 60: 1249–56?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J Am Coll Cardiol. 2012 issue 60: 1249–56?. ### Response: 2012.


Instruction: What is the Framingham Heart Study?

Output: Prognostic utility of novel bio-markers of cardiovascular stress

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Framingham Heart Study?. ### Response: Prognostic utility of novel bio-markers of cardiovascular stress.


Instruction: What is a novel biomarker of cardiovascular stress?

Output: bio-markers of cardiovascular stress: the Framingham Heart Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a novel biomarker of cardiovascular stress?. ### Response: bio-markers of cardiovascular stress: the Framingham Heart Study.


Instruction: What is NICE 2018?

Output: Chronic Heart Failure  Monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE 2018?. ### Response: Chronic Heart Failure  Monitoring.


Instruction: Who is subject to Notice of Rights?

Output: Chronic Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is subject to Notice of Rights?. ### Response: Chronic Heart Failure.


Instruction: What is the name of the study that evaluated thromboembolic and bleeding complications following St. Jude Medical valve replacement?

Output: German Experience With Low-Intensity Anticoagulation Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated thromboembolic and bleeding complications following St. Jude Medical valve replacement?. ### Response: German Experience With Low-Intensity Anticoagulation Study.


Instruction: What is AREVA: multicenter randomized compari-son of?

Output: low-dose versus standard-dose anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is AREVA: multicenter randomized compari-son of?. ### Response: low-dose versus standard-dose anticoagulation.


Instruction: What is the name of the multicenter randomized trial of anticoagulation in mechanical prosthetic heart valves?

Output: AREVA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multicenter randomized trial of anticoagulation in mechanical prosthetic heart valves?. ### Response: AREVA.


Instruction: When was AREVA published?

Output: 1996

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was AREVA published?. ### Response: 1996.


Instruction: How many patients were enrolled in the study?

Output: 7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were enrolled in the study?. ### Response: 7.


Instruction: What type of disease is valvular?

Output: valvular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of disease is valvular?. ### Response: valvular disease.


Instruction: What is the 2014 AHA/ACC NSTE-ACS Guideline e399 194?

Output: Amsterdam et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2014 AHA/ACC NSTE-ACS Guideline e399 194?. ### Response: Amsterdam et al.


Instruction: What are the mechanisms behind the prognostic value of troponin T in unstable coronary artery disease?

Output: a FRISC II substudy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the mechanisms behind the prognostic value of troponin T in unstable coronary artery disease?. ### Response: a FRISC II substudy.


Instruction: What is Abciximab used for in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment?

Output: ISAR-REACT 2 randomized trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Abciximab used for in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment?. ### Response: ISAR-REACT 2 randomized trial.


Instruction: When was the ISAR-REACT 2 randomized trial conducted?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the ISAR-REACT 2 randomized trial conducted?. ### Response: 2006.


Instruction: What is used to detect myocardial infarc-tion?

Output: Simultaneous rapid mea-surement of whole blood myoglobin, creatine kinase MB, and cardiac troponin I by the triage cardiac panel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used to detect myocardial infarc-tion?. ### Response: Simultaneous rapid mea-surement of whole blood myoglobin, creatine kinase MB, and cardiac troponin I by the triage cardiac panel.


Instruction: What is the triage cardiac panel used for?

Output: detection of myocardial infarc-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the triage cardiac panel used for?. ### Response: detection of myocardial infarc-tion.


Instruction: When was the Clin Chem.45:199–205?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Clin Chem.45:199–205?. ### Response: 1999.


Instruction: What does creatine kinase muscle-brain fraction predict?

Output: cardiac risk and benefit of an invasive strategy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does creatine kinase muscle-brain fraction predict?. ### Response: cardiac risk and benefit of an invasive strategy.


Instruction: What does troponin T compare to to predict cardiac risk and benefit of an invasive strategy in patients with non-ST-elevation acute coronary syndromes?

Output: creatine kinase muscle-brain fraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does troponin T compare to to predict cardiac risk and benefit of an invasive strategy in patients with non-ST-elevation acute coronary syndromes?. ### Response: creatine kinase muscle-brain fraction.


Instruction: When did J Am Coll Cardiol. 2002;40:1044–50?

Output: 198

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J Am Coll Cardiol. 2002;40:1044–50?. ### Response: 198.


Instruction: What is the frequency and outcomes of cardiac biomarkers in emergency department patients with chest pain?

Output: Discordant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the frequency and outcomes of cardiac biomarkers in emergency department patients with chest pain?. ### Response: Discordant.


Instruction: When did Ann Emerg Med. 2006 issue 48:660-5?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Ann Emerg Med. 2006 issue 48:660-5?. ### Response: 2006.


Instruction: What was Aviles RJ, Askari AT, Lindahl B, et al. doing with acute coronary syndromes, with or without renal dysfunction?

Output: Troponin T levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was Aviles RJ, Askari AT, Lindahl B, et al. doing with acute coronary syndromes, with or without renal dysfunction?. ### Response: Troponin T levels.


Instruction: What year did N Engl J Med issue 346: 2047-52?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did N Engl J Med issue 346: 2047-52?. ### Response: 2002.


Instruction: What is the name of the clinical trial of a chest-pain observation unit for patients with unstable angina?

Output: Farkouh ME, Smars PA, Reeder GS, et al. A clinical trial of a chest-pain observation unit for patients with unstable angina. Chest Pain Evaluation in the Emergency Room (CHEER) Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the clinical trial of a chest-pain observation unit for patients with unstable angina?. ### Response: Farkouh ME, Smars PA, Reeder GS, et al. A clinical trial of a chest-pain observation unit for patients with unstable angina. Chest Pain Evaluation in the Emergency Room (CHEER) Investigators.


Instruction: Who are the Chest Pain Evaluation in the Emergency Room Investigators?

Output: Farkouh ME, Smars PA, Reeder GS, et al. A clinical trial of a chest-pain observation unit for patients with unstable angina

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who are the Chest Pain Evaluation in the Emergency Room Investigators?. ### Response: Farkouh ME, Smars PA, Reeder GS, et al. A clinical trial of a chest-pain observation unit for patients with unstable angina.


Instruction: What does ROMIO stand for?

Output: randomized study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ROMIO stand for?. ### Response: randomized study.


Instruction: What is the name of the randomized study used to rule out myocardial ischemia?

Output: ROMIO

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized study used to rule out myocardial ischemia?. ### Response: ROMIO.


Instruction: When was the J Am Coll Cardiol. 1996 published?

Output: 28:25–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol. 1996 published?. ### Response: 28:25–.


Instruction: What did Kirk JD, Diercks DB, et al. use to evaluate low-risk patients presenting to the emergency department with chest pain?

Output: Immediate exercise test-ing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Kirk JD, Diercks DB, et al. use to evaluate low-risk patients presenting to the emergency department with chest pain?. ### Response: Immediate exercise test-ing.


Instruction: What did Trippi JA, Lee KS use as a clinical service?

Output: Dobutamine stress tele-echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Trippi JA, Lee KS use as a clinical service?. ### Response: Dobutamine stress tele-echocardiography.


Instruction: Echocardiography. 1999;16:179–85.

Output: 204

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Echocardiography. 1999;16:179–85.. ### Response: 204.


Instruction: What is the emergency department to evaluate patients with chest pain?

Output: Dobutamine stress tele-echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the emergency department to evaluate patients with chest pain?. ### Response: Dobutamine stress tele-echocardiography.


Instruction: Bholasingh R, Cornel JH, Kamp O, et al. Prognostic value of what in chest pain patients with a negative cardiac troponin T?

Output: predis-charge dobutamine stress echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Bholasingh R, Cornel JH, Kamp O, et al. Prognostic value of what in chest pain patients with a negative cardiac troponin T?. ### Response: predis-charge dobutamine stress echocardiography.


Instruction: What type of CT angiog-raphy versus standard evaluation in acute chest pain?

Output: Coronary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of CT angiog-raphy versus standard evaluation in acute chest pain?. ### Response: Coronary.


Instruction: What year did N Engl J Med issue 367:299–308.

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did N Engl J Med issue 367:299–308.. ### Response: 2012.


Instruction: What is CT angiography for?

Output: safe discharge of patients with possible acute coronary syndromes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CT angiography for?. ### Response: safe discharge of patients with possible acute coronary syndromes.


Instruction: What are patients with possible acute coronary syndromes?

Output: non-ST-ele-vation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients with possible acute coronary syndromes?. ### Response: non-ST-ele-vation.


Instruction: What is the N Engl J Med 2012 366:1393–403.

Output: CT angiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the N Engl J Med 2012 366:1393–403.. ### Response: CT angiography.


Instruction: What is the optimal time to switch from DAPT to SAPT to maximize benefit and reduce risk?

Output: first 21 days after the event

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the optimal time to switch from DAPT to SAPT to maximize benefit and reduce risk?. ### Response: first 21 days after the event.


Instruction: Stroke. 2021;52:e364–e467.

Output: e428  July 2021

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Stroke. 2021;52:e364–e467.. ### Response: e428  July 2021.


Instruction: What may be maximized as early as the first 21 days after the event?

Output: benefit in stroke reduction with DAPT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be maximized as early as the first 21 days after the event?. ### Response: benefit in stroke reduction with DAPT.


Instruction: What is the treatment approach summa-rized in Figure 6?

Output: Antiplatelet therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the treatment approach summa-rized in Figure 6?. ### Response: Antiplatelet therapy.


Instruction: What is SAPT?

Output: DAPT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SAPT?. ### Response: DAPT.


Instruction: How many patients were randomized in the WARSS study?

Output: 2206

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were randomized in the WARSS study?. ### Response: 2206.


Instruction: What is not recommended on the basis of increased bleeding risk?

Output: Tri-ple therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended on the basis of increased bleeding risk?. ### Response: Tri-ple therapy.


Instruction: How many patients had a stroke not attributable to cardioembolism or high-grade carotid stenosis?

Output: 2206

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had a stroke not attributable to cardioembolism or high-grade carotid stenosis?. ### Response: 2206.


Instruction: What was the pri-mary end point of 2-year recurrent ischemic stroke or death?

Output: no different between the 2 groups

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the pri-mary end point of 2-year recurrent ischemic stroke or death?. ### Response: no different between the 2 groups.


Instruction: What was the HR of a sub-sequent meta-analysis of 8 other trials of VKA among 5762 patients with TIA or nondisabling noncardioembolic stroke?

Output: 1.13

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the HR of a sub-sequent meta-analysis of 8 other trials of VKA among 5762 patients with TIA or nondisabling noncardioembolic stroke?. ### Response: 1.13.


Instruction: What did the sub-analysis find no benefit in sec-ondary stroke prevention with the use of oral anti-coagulation of various intensities?

Output: increased bleeding risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the sub-analysis find no benefit in sec-ondary stroke prevention with the use of oral anti-coagulation of various intensities?. ### Response: increased bleeding risk.


Instruction: What was the RR of medium-intensity anticoagulation?

Output: 0.80

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the RR of medium-intensity anticoagulation?. ### Response: 0.80.


Instruction: What is the CI of RR?

Output: 0.56–1.14

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the CI of RR?. ### Response: 0.56–1.14.


Instruction: How was RR associated with a significantly increased risk of bleeding?

Output: both medium-intensity anticoagulation and high-intensity anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was RR associated with a significantly increased risk of bleeding?. ### Response: both medium-intensity anticoagulation and high-intensity anticoagulation.


Instruction: When were single antiplatelet trials conducted in patients?

Output: noncardioembolic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When were single antiplatelet trials conducted in patients?. ### Response: noncardioembolic stroke.


Instruction: What did a series of single antiplatelet trials not use in the same man-ner as the more recent DAPT trials?

Output: clinical eligibility criteria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a series of single antiplatelet trials not use in the same man-ner as the more recent DAPT trials?. ### Response: clinical eligibility criteria.


Instruction: What group may qualify for the more Figure 6?

Output: embolic stroke pathogenesis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What group may qualify for the more Figure 6?. ### Response: embolic stroke pathogenesis.


Instruction: What is the term for noncardioembolic stroke and transient ischemic attack?

Output: TIA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for noncardioembolic stroke and transient ischemic attack?. ### Response: TIA.


Instruction: What does TIA stand for?

Output: transient ischemic attack

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does TIA stand for?. ### Response: transient ischemic attack.


Instruction: What is early ischemic stroke?

Output: <24 hours from onset

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is early ischemic stroke?. ### Response: <24 hours from onset.


Instruction: How long after onset does IS occur?

Output: <24 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after onset does IS occur?. ### Response: <24 hours.


Instruction: What is low-risk TIA?

Output: ABCD2 score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is low-risk TIA?. ### Response: ABCD2 score.


Instruction: Which color corresponds to Class of Recommendation in Table 3?

Output: Colors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which color corresponds to Class of Recommendation in Table 3?. ### Response: Colors.


Instruction: When was the data from Brown et al. downloaded?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the data from Brown et al. downloaded?. ### Response: April 28, 2023.


Instruction: Where did the data come from?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where did the data come from?. ### Response: http://ahajournals.org.


Instruction: What was the date of the download?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the date of the download?. ### Response: April 28, 2023.


Instruction: When did Brown and Pan publish their data?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Brown and Pan publish their data?. ### Response: April 28, 2023.


Instruction: What is the TIMI risk score determined by?

Output: the sum of the presence of 7 variables at admission

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the TIMI risk score determined by?. ### Response: the sum of the presence of 7 variables at admission.


Instruction: How many variables are present at admission?

Output: 7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many variables are present at admission?. ### Response: 7.


Instruction: What is given for each of the following variables?

Output: 1 point

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is given for each of the following variables?. ### Response: 1 point.


Instruction: How many risk factors are there for CAD?

Output: ≥ 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many risk factors are there for CAD?. ### Response: ≥ 3.


Instruction: How many anginal events were there in prior 24 h?

Output: ≥ 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many anginal events were there in prior 24 h?. ### Response: ≥ 2.


Instruction: What does CAD indicate?

Output: coronary artery disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CAD indicate?. ### Response: coronary artery disease.


Instruction: What indicates coronary artery disease?

Output: CAD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates coronary artery disease?. ### Response: CAD.


Instruction: What indicates myocardial infarction?

Output: Ml

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates myocardial infarction?. ### Response: Ml.


Instruction: NSTE-ACS indicates what?

Output: non-ST-elevation acute coronary syndromes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: NSTE-ACS indicates what?. ### Response: non-ST-elevation acute coronary syndromes.


Instruction: What is fenofibrate a treatment option for?

Output: dyslipidemia and elevated triglycer -ide levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is fenofibrate a treatment option for?. ### Response: dyslipidemia and elevated triglycer -ide levels.


Instruction: What is the name of the fibric acid derivative that activates the peroxisome proliferator-activated receptor-?

Output: Fenofibrate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the fibric acid derivative that activates the peroxisome proliferator-activated receptor-?. ### Response: Fenofibrate.


Instruction: What is a fibric acid derivative that activates the peroxisome proliferator-activated receptor-?

Output: Fenofibrate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a fibric acid derivative that activates the peroxisome proliferator-activated receptor-?. ### Response: Fenofibrate.


Instruction: Compared with statin monotherapy, fenofibrate monotherapy tends to improve what?

Output: triglyceride and HDL cholesterol levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Compared with statin monotherapy, fenofibrate monotherapy tends to improve what?. ### Response: triglyceride and HDL cholesterol levels.


Instruction: What is the name of the Fenofibrate Intervention and Event Lowering in Diabetes study?

Output: FIELD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Fenofibrate Intervention and Event Lowering in Diabetes study?. ### Response: FIELD.


Instruction: How many patients with diabetes mellitus who were not taking statins were randomized to micronized fenobrate 200 mg daily or matching placebo for 5 years?

Output: 9797

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with diabetes mellitus who were not taking statins were randomized to micronized fenobrate 200 mg daily or matching placebo for 5 years?. ### Response: 9797.


Instruction: How long did fenofibrate help reduce the risk of cardio-vascular death or nonfatal MI?

Output: 5 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did fenofibrate help reduce the risk of cardio-vascular death or nonfatal MI?. ### Response: 5 years.


Instruction: What was the HR of the placebo for 5 years?

Output: 0.89

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the HR of the placebo for 5 years?. ### Response: 0.89.


Instruction: How was the second-ary end point of total cardiovascular events reduced?

Output: fenofibrate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the second-ary end point of total cardiovascular events reduced?. ### Response: fenofibrate.


Instruction: What is a point of total cardiovascular events?

Output: second-ary end point

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a point of total cardiovascular events?. ### Response: second-ary end point.


Instruction: When was this file downloaded?

Output: April 26, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this file downloaded?. ### Response: April 26, 2023.


Instruction: Who is the Chair of Harvard Medical School?

Output: Patrick T. O’Gara

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Chair of Harvard Medical School?. ### Response: Patrick T. O’Gara.


Instruction: What is the name of the Vice Chair of Tulane University School of Medicine?

Output: Frederick G. Kushner

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Vice Chair of Tulane University School of Medicine?. ### Response: Frederick G. Kushner.


Instruction: Who is an Associate Professor of Medicine at Mount Sinai School of Medicine?

Output: Deborah  D. Ascheim

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is an Associate Professor of Medicine at Mount Sinai School of Medicine?. ### Response: Deborah  D. Ascheim.


Instruction: Who is a Clinical Director of Research at the Philip R. Lee Institute for Health Policy Studies at UCSF?

Output: Deborah  D. Ascheim

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a Clinical Director of Research at the Philip R. Lee Institute for Health Policy Studies at UCSF?. ### Response: Deborah  D. Ascheim.


Instruction: What College of Population Health is adjunct faculty?

Output: Thomas Jefferson

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What College of Population Health is adjunct faculty?. ### Response: Thomas Jefferson.


Instruction: Who is the founder of IPO4Health?

Output: Alvarez

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the founder of IPO4Health?. ### Response: Alvarez.


Instruction: What is the name of the foundation that is the professor of medicine?

Output: Cleveland Clinic Foundation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the foundation that is the professor of medicine?. ### Response: Cleveland Clinic Foundation.


Instruction: Who is the professor of medicine at LemosUT Southwestern Medical Center?

Output: James A.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the professor of medicine at LemosUT Southwestern Medical Center?. ### Response: James A..


Instruction: What is the name of the Distinguished Chair in Clinical Care and Research held by Borah B. Diercks?

Output: Audre and Bernard Rapoport

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Distinguished Chair in Clinical Care and Research held by Borah B. Diercks?. ### Response: Audre and Bernard Rapoport.


Instruction: On what date was this article published?

Output: May 3, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On what date was this article published?. ### Response: May 3, 2023.


Instruction: Where can this article be found?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can this article be found?. ### Response: http://ahajournals.org.


Instruction: What is used to monitor out-of-office BP levels?

Output: Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used to monitor out-of-office BP levels?. ### Response: Hypertension.


Instruction: What are BP thresh-olds used to define hypertension with?

Output: ABPM or HBPM read-ings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are BP thresh-olds used to define hypertension with?. ### Response: ABPM or HBPM read-ings.


Instruction: How many data address reproducibility of these hypertension profiles over time?

Output: few

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many data address reproducibility of these hypertension profiles over time?. ### Response: few.


Instruction: How many studies suggest the progression of white coat hypertension to sustained office-measured hypertension?

Output: several

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies suggest the progression of white coat hypertension to sustained office-measured hypertension?. ### Response: several.


Instruction: What are recommendations for Masked and White Coat Hypertension summarized in online data supplements 4, 5, and 6?

Output: References that support recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are recommendations for Masked and White Coat Hypertension summarized in online data supplements 4, 5, and 6?. ### Response: References that support recommendations.


Instruction: What type of hypertension can be detected in adults with untreated SBP greater than 130 mm Hg but less than 160 mm hg?

Output: white coat

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of hypertension can be detected in adults with untreated SBP greater than 130 mm Hg but less than 160 mm hg?. ### Response: white coat.


Instruction: What is a reasonable way to screen for white coat hypertension?

Output: daytime ABPM or HBPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a reasonable way to screen for white coat hypertension?. ### Response: daytime ABPM or HBPM.


Instruction: What is reasonable to detect transition to sustained hypertension in adults with white coat hypertension?

Output: periodic monitoring with either ABPM or HBPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable to detect transition to sustained hypertension in adults with white coat hypertension?. ### Response: periodic monitoring with either ABPM or HBPM.


Instruction: In adults being treated for hypertension with office BP, what is reasonable?

Output: to screen for the presence of white coat hypertension by using either daytime ABPM or HBPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In adults being treated for hypertension with office BP, what is reasonable?. ### Response: to screen for the presence of white coat hypertension by using either daytime ABPM or HBPM.


Instruction: What can be useful in adults being treated for hypertension with office BP readings not at goal and HBPM readings suggestive of a significant white coat effect?

Output: confirmation by ABPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be useful in adults being treated for hypertension with office BP readings not at goal and HBPM readings suggestive of a significant white coat effect?. ### Response: confirmation by ABPM.


Instruction: What is a reasonable screening for masked hypertension?

Output: HBPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a reasonable screening for masked hypertension?. ### Response: HBPM.


Instruction: What is an acceptable screening for DBP?

Output: greater than 80 mm Hg but less than 100 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an acceptable screening for DBP?. ### Response: greater than 80 mm Hg but less than 100 mm Hg.


Instruction: In adults on multiple-drug therapies for hypertension and office BPs within 10 mm Hg above goal, what is the recommended screening?

Output: white coat effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In adults on multiple-drug therapies for hypertension and office BPs within 10 mm Hg above goal, what is the recommended screening?. ### Response: white coat effect.


Instruction: What may be reasonable to screen for white coat effect with HBPM?

Output: In adults on multiple-drug therapies for hypertension and office BPs within 10 mm Hg above goal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be reasonable to screen for white coat effect with HBPM?. ### Response: In adults on multiple-drug therapies for hypertension and office BPs within 10 mm Hg above goal.


Instruction: What type of readings suggest masked uncontrolled hypertension?

Output: elevated HBPM readings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of readings suggest masked uncontrolled hypertension?. ### Response: elevated HBPM readings.


Instruction: What might be reasonable before intensification of antihypertensive medication?

Output: confirmation of the diagnosis by ABPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What might be reasonable before intensification of antihypertensive medication?. ### Response: confirmation of the diagnosis by ABPM.


Instruction: What might be reasonable before intensification of antihypertensive drug treatment?

Output: confirmation of the diagnosis by ABPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What might be reasonable before intensification of antihypertensive drug treatment?. ### Response: confirmation of the diagnosis by ABPM.


Instruction: What has resulted in differentiation of hypertension into several clinical useful categories?

Output: The availability of noninvasive BP monitoring techniques

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has resulted in differentiation of hypertension into several clinical useful categories?. ### Response: The availability of noninvasive BP monitoring techniques.


Instruction: What is masked hypertension?

Output: office readings sug-gesting normal BP but out-of-office (ABPM/HBPM) read-ings that are consistently above normal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is masked hypertension?. ### Response: office readings sug-gesting normal BP but out-of-office (ABPM/HBPM) read-ings that are consistently above normal.


Instruction: What is white coat hypertension characterized by elevated office BP but normal readings when measured outside the office?

Output: masked hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is white coat hypertension characterized by elevated office BP but normal readings when measured outside the office?. ### Response: masked hypertension.


Instruction: What are out-of-office (ABPM/HBPM) read-ings that are consistently above normal?

Output: BP thresh-olds

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are out-of-office (ABPM/HBPM) read-ings that are consistently above normal?. ### Response: BP thresh-olds.


Instruction: How many trials have examined drug treatment of dyslipide-mia primarily in children with nephrotic syndrome?

Output: Fourrandomized trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many trials have examined drug treatment of dyslipide-mia primarily in children with nephrotic syndrome?. ### Response: Fourrandomized trials.


Instruction: What is dyslipide-mia primarily treated for in children with nephrotic syndrome?

Output: drug treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is dyslipide-mia primarily treated for in children with nephrotic syndrome?. ### Response: drug treatment.


Instruction: Statins lower what over 7 months to 5 years?

Output: LDL-C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Statins lower what over 7 months to 5 years?. ### Response: LDL-C.


Instruction: How many placebo-controlled trials of statins have been conducted in 1683 children with dyslipidemias and normal kidneys?

Output: 13

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many placebo-controlled trials of statins have been conducted in 1683 children with dyslipidemias and normal kidneys?. ### Response: 13.


Instruction: How many children had trials of statins in 1683?

Output: 13

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many children had trials of statins in 1683?. ### Response: 13.


Instruction: What does not apply to children with severe elevated LDL-C?

Output: statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not apply to children with severe elevated LDL-C?. ### Response: statins.


Instruction: Who should adopt therapeutic lifestyle changes among all children with CKD?

Output: practitioners

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should adopt therapeutic lifestyle changes among all children with CKD?. ### Response: practitioners.


Instruction: What is a problem with treatment strategies based onlifetime risk?

Output: lack of data onthe long-term follow-up of randomized clinical trials 415years in the general population

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a problem with treatment strategies based onlifetime risk?. ### Response: lack of data onthe long-term follow-up of randomized clinical trials 415years in the general population.


Instruction: How long does it take to follow up randomized clinical trials in the general population?

Output: 415years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take to follow up randomized clinical trials in the general population?. ### Response: 415years.


Instruction: How long has statins been used in the general population?

Output: 410 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long has statins been used in the general population?. ### Response: 410 years.


Instruction: How long does statin be used in individuals o40 years of age?

Output: 410 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does statin be used in individuals o40 years of age?. ### Response: 410 years.


Instruction: What is the name of the treatment used in adults with CKD?

Output: Triglyceride-lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the treatment used in adults with CKD?. ### Response: Triglyceride-lowering.


Instruction: What do we suggest in children with CKD?

Output: therapeutic lifestyle changes be advised

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do we suggest in children with CKD?. ### Response: therapeutic lifestyle changes be advised.


Instruction: What is a recommendation for therapeutic treatment of high TGS in adults?

Output: NO

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a recommendation for therapeutic treatment of high TGS in adults?. ### Response: NO.


Instruction: How many randomized trials did the MADEA meta-analysis of data from?

Output: 18

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many randomized trials did the MADEA meta-analysis of data from?. ### Response: 18.


Instruction: How much relative risk reduction in major cardiovascular events was there for fibrate therapy?

Output: 10%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much relative risk reduction in major cardiovascular events was there for fibrate therapy?. ### Response: 10%.


Instruction: What was the relativerisk reduction in coronary events?

Output: 13%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the relativerisk reduction in coronary events?. ### Response: 13%.


Instruction: What is FIELD?

Output: The Fenofibrate Interventionand Event Lowering in Diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is FIELD?. ### Response: The Fenofibrate Interventionand Event Lowering in Diabetes.


Instruction: What is ACCORD-Lipid?

Output: Actionto Control Cardiovascular Risk in Diabetes-Lipid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ACCORD-Lipid?. ### Response: Actionto Control Cardiovascular Risk in Diabetes-Lipid.


Instruction: How many participants with eGFR o60 ml/min per 1.73 m2were included in either the Fenofibrate Interventionand Event Lowering in Diabetes?

Output: Too few

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many participants with eGFR o60 ml/min per 1.73 m2were included in either the Fenofibrate Interventionand Event Lowering in Diabetes?. ### Response: Too few.


Instruction: What was associated with an increased risk of doubling of plasmacreatinine?

Output: Allocation to fenofibrate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with an increased risk of doubling of plasmacreatinine?. ### Response: Allocation to fenofibrate.


Instruction: What did a recent large observational study in patients aged466 years demonstrate a clear association between?

Output: new

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a recent large observational study in patients aged466 years demonstrate a clear association between?. ### Response: new.


Instruction: How old were the patients in the study?

Output: 466 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old were the patients in the study?. ### Response: 466 years.


Instruction: What did the study show?

Output: statins lower LDL-C over 7 months to 5 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the study show?. ### Response: statins lower LDL-C over 7 months to 5 years.


Instruction: What are evidence profiles constructed to assess?

Output: quality andrecord quality grades and descriptions of effect for eachoutcome across studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are evidence profiles constructed to assess?. ### Response: quality andrecord quality grades and descriptions of effect for eachoutcome across studies.


Instruction: What aim do evidence profiles aim to make?

Output: trans-parent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What aim do evidence profiles aim to make?. ### Response: trans-parent.


Instruction: What do outcomes aim to make the evidence synthesis process trans-parent?

Output: deﬁnition

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do outcomes aim to make the evidence synthesis process trans-parent?. ### Response: deﬁnition.


Instruction: Decisions in the evidence profiles were based on data from what?

Output: methodology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Decisions in the evidence profiles were based on data from what?. ### Response: methodology.


Instruction: How many studies were there?

Output: 8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were there?. ### Response: 8.


Instruction: What did the summary table provide?

Output: theﬁnal level of synthesis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the summary table provide?. ### Response: theﬁnal level of synthesis.


Instruction: Who first constructed the evidence profile?

Output: the ERT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who first constructed the evidence profile?. ### Response: the ERT.


Instruction: What are the work products created by the ERT forsummarizing the evidence base listed in?

Output: Table 9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the work products created by the ERT forsummarizing the evidence base listed in?. ### Response: Table 9.


Instruction: What refers to thedesign, conduct, and reporting of outcomes of a clinicalstudy?

Output: Methodological quality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What refers to thedesign, conduct, and reporting of outcomes of a clinicalstudy?. ### Response: Methodological quality.


Instruction: A previously devised three-level classification system was used to grade what?

Output: overall studyquality and quality of all relevant outcomes in the study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A previously devised three-level classification system was used to grade what?. ### Response: overall studyquality and quality of all relevant outcomes in the study.


Instruction: What classification system was used to grade the overall study quality?

Output: three-level

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What classification system was used to grade the overall study quality?. ### Response: three-level.


Instruction: Who graded the individual studies?

Output: one ofthe reviewers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who graded the individual studies?. ### Response: one ofthe reviewers.


Instruction: What was done by one reviewer, then confirmed by another?

Output: Grading of individual studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was done by one reviewer, then confirmed by another?. ### Response: Grading of individual studies.


Instruction: What type of meeting has been used in most KDOQI and all KDIGO guidelines?

Output: agroup meeting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of meeting has been used in most KDOQI and all KDIGO guidelines?. ### Response: agroup meeting.


Instruction: What has been recommended by the US Agency for Healthcare Research and Quality Evidence-based Practice Center program?

Output: Variations of this system

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been recommended by the US Agency for Healthcare Research and Quality Evidence-based Practice Center program?. ### Response: Variations of this system.


Instruction: What is the main difference between atorvastatin and ezetimibe in RCTs?

Output: placebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the main difference between atorvastatin and ezetimibe in RCTs?. ### Response: placebo.


Instruction: What are some of the main differences between atorsatin and placebo?

Output: outcomes, appropriate use of statisticalmethods, etc.),

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the main differences between atorsatin and placebo?. ### Response: outcomes, appropriate use of statisticalmethods, etc.),.


Instruction: How many studies were there in the single study?

Output: 8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were there in the single study?. ### Response: 8.


Instruction: What is the difference between statin + ezetimibe vs. simvastatin in ADPKD?

Output: placebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between statin + ezetimibe vs. simvastatin in ADPKD?. ### Response: placebo.


Instruction: What are the differences between Statin and placebo in CKD in a single study?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the differences between Statin and placebo in CKD in a single study?. ### Response: + –.


Instruction: What is the difference between Statin + ezetimibe vs. placebo?

Output: – (single

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between Statin + ezetimibe vs. placebo?. ### Response: – (single.


Instruction: How many studies did Statin and lifestyle compare in transplant recipients?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies did Statin and lifestyle compare in transplant recipients?. ### Response: 2.


Instruction: What was the difference in children with CKD with dialysis?

Output: Statin vs. placebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the difference in children with CKD with dialysis?. ### Response: Statin vs. placebo.


Instruction: How many studies did there be in CKD with dialysis?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies did there be in CKD with dialysis?. ### Response: 2.


Instruction: Exercise vs. control + – (single study)Drug interactions (update of Tables 32-37 in KDOQI 2003 guideline)Does statin+fibrate therapy cause adverse events?

Output: Adverse events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Exercise vs. control + – (single study)Drug interactions (update of Tables 32-37 in KDOQI 2003 guideline)Does statin+fibrate therapy cause adverse events?. ### Response: Adverse events.


Instruction: What is the VA/DoD Clinical Practice Guideline for the Diagnosis and Management of Hypertension in the Primary Care Setting?

Output: Page 32 of 134

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for the Diagnosis and Management of Hypertension in the Primary Care Setting?. ### Response: Page 32 of 134.


Instruction: What is more readily available than ABPM and requires fewer resources?

Output: HBPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more readily available than ABPM and requires fewer resources?. ### Response: HBPM.


Instruction: What type of education is recommended?

Output: careful patient education

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of education is recommended?. ### Response: careful patient education.


Instruction: What is needed to evaluate the effectiveness of using out-of-office bloo d pressure to manage HTN?

Output: More research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed to evaluate the effectiveness of using out-of-office bloo d pressure to manage HTN?. ### Response: More research.


Instruction: What would improve cardiovascular morbidity and mortality in hypertensive individuals?

Output: treating to ABPM or HBPM guided blood pressure goals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would improve cardiovascular morbidity and mortality in hypertensive individuals?. ### Response: treating to ABPM or HBPM guided blood pressure goals.


Instruction: What is Monitoring Recommendation 5 among patients treated for hypertension?

Output: home blood pressure self -monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Monitoring Recommendation 5 among patients treated for hypertension?. ### Response: home blood pressure self -monitoring.


Instruction: Home blood pressure self monitoring has been shown to improve SB P and DBP control when paired with what?

Output: a co -intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Home blood pressure self monitoring has been shown to improve SB P and DBP control when paired with what?. ### Response: a co -intervention.


Instruction: How many SRs were found in our evidence review?

Output: two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many SRs were found in our evidence review?. ### Response: two.


Instruction: How many SRs of RCTs showed improved blood pressure control compared to usual care?

Output: Three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many SRs of RCTs showed improved blood pressure control compared to usual care?. ### Response: Three.


Instruction: What was the adjusted MD in SBP?

Output: 2.7 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the adjusted MD in SBP?. ### Response: 2.7 mm Hg.


Instruction: What is the SBP of 2.7 mm Hg?

Output: adjusted MD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the SBP of 2.7 mm Hg?. ### Response: adjusted MD.


Instruction: What was not associated with lower blood pressure when paired with co-interventions?

Output: self-monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not associated with lower blood pressure when paired with co-interventions?. ### Response: self-monitoring.


Instruction: What was associated with a lower blood pressure?

Output: blood pressure self-monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with a lower blood pressure?. ### Response: blood pressure self-monitoring.


Instruction: What was the MD in SBP - 6.1 mm Hg?

Output: lower blood pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the MD in SBP - 6.1 mm Hg?. ### Response: lower blood pressure.


Instruction: How many additional RCTs had results consistent with the SRs?

Output: Three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many additional RCTs had results consistent with the SRs?. ### Response: Three.


Instruction: What is accompanied by a co -intervention involving medi cation titration in response to self-monitoring data?

Output: self- monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is accompanied by a co -intervention involving medi cation titration in response to self-monitoring data?. ### Response: self- monitoring.


Instruction: Studies in which medication adherence was examined revealed no difference in what?

Output: medication adherence between self -monitoring of blood pressure and usual care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Studies in which medication adherence was examined revealed no difference in what?. ### Response: medication adherence between self -monitoring of blood pressure and usual care.


Instruction: What did the Work Group members ask about a 2 -4 mm Hg reduction in blood pressure?

Output: whether a 2 -4 mm Hg reduction in blood pressure was clinically significant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Work Group members ask about a 2 -4 mm Hg reduction in blood pressure?. ### Response: whether a 2 -4 mm Hg reduction in blood pressure was clinically significant.


Instruction: How much blood pressure reduction was clinically significant?

Output: 2 -4 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much blood pressure reduction was clinically significant?. ### Response: 2 -4 mm Hg.


Instruction: Who expressed a desire for additional education on the use of home blood pressure management?

Output: patient focus gro up participants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who expressed a desire for additional education on the use of home blood pressure management?. ### Response: patient focus gro up participants.


Instruction: What might some patients not want the extra burden of monitoring their own blood pressure at home?

Output: variability in provider and patient preferences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What might some patients not want the extra burden of monitoring their own blood pressure at home?. ### Response: variability in provider and patient preferences.


Instruction: What is the added cost of a home blood pressure monitor if not provided by the institution?

Output: patients in whom HBPM is not feasible

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the added cost of a home blood pressure monitor if not provided by the institution?. ### Response: patients in whom HBPM is not feasible.


Instruction: What is the systemic implications of aneurysmalsubarachnoid hemorrhage?

Output: glucose and brain energy metabolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the systemic implications of aneurysmalsubarachnoid hemorrhage?. ### Response: glucose and brain energy metabolism.


Instruction: What are the causes and predictors of non-infectious fever in the neurologicalintensive care unit?

Output: incidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the causes and predictors of non-infectious fever in the neurologicalintensive care unit?. ### Response: incidence.


Instruction: What increased in-hospital mortality after subarachnoid hemorrhage?

Output: Fever

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What increased in-hospital mortality after subarachnoid hemorrhage?. ### Response: Fever.


Instruction: What is a case-control study?

Output: ach-noid hemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a case-control study?. ### Response: ach-noid hemorrhage.


Instruction: What is the outcome after subarachnoid hemorrhage?

Output: Systemic glucose and brain energy metabolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the outcome after subarachnoid hemorrhage?. ### Response: Systemic glucose and brain energy metabolism.


Instruction: What is the name of the group that studies admission glucose level and clinical outcomes in the NINDS rt-PA Stroke Trial?

Output: NINDS rt-PA StrokeStudy Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that studies admission glucose level and clinical outcomes in the NINDS rt-PA Stroke Trial?. ### Response: NINDS rt-PA StrokeStudy Group.


Instruction: What is Krinsley JS's profession?

Output: Neurosurgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Krinsley JS's profession?. ### Response: Neurosurgery.


Instruction: What is the effect of dextrose infusion and head position on neurologicoutcome after complete cerebral ischemia in primates?

Output: examination of amodel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of dextrose infusion and head position on neurologicoutcome after complete cerebral ischemia in primates?. ### Response: examination of amodel.


Instruction: What is complete cerebral ischemia in primates?

Output: examination of amodel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is complete cerebral ischemia in primates?. ### Response: examination of amodel.


Instruction: What is the name of the study that examined amodel?

Output: Anesthesiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined amodel?. ### Response: Anesthesiology.


Instruction: When did Longstreth WT Jr, Diehr P, Inui TS, predict of awakening after cardiac arrest?

Output: 1983

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Longstreth WT Jr, Diehr P, Inui TS, predict of awakening after cardiac arrest?. ### Response: 1983.


Instruction: What is an independent predictor of poor outcome after acute stroke?

Output: hyperglycaemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an independent predictor of poor outcome after acute stroke?. ### Response: hyperglycaemia.


Instruction: What is the name of the study that examined the effects of glucose on ischemic brain injury?

Output: NINDS rt-PA Stroke Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined the effects of glucose on ischemic brain injury?. ### Response: NINDS rt-PA Stroke Trial.


Instruction: What is a predictor of poor outcome after acute stroke?

Output: hyperglycaemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a predictor of poor outcome after acute stroke?. ### Response: hyperglycaemia.


Instruction: What are the results of along-term follow up study?

Output: hyperglycaemia anindependent predictor of poor outcome after acute stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of along-term follow up study?. ### Response: hyperglycaemia anindependent predictor of poor outcome after acute stroke.


Instruction: When was the BMJ 314:1303–1306.323?

Output: 1997

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the BMJ 314:1303–1306.323?. ### Response: 1997.


Instruction: Inpatient hyperglycemia fol-lowing aneurysmal subarachnoid hemorrhage: relation to cerebral me-tabolism and outcome?

Output: Relationship betweenadmission hyperglycemia and neurologic outcome of severely brain-injured patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Inpatient hyperglycemia fol-lowing aneurysmal subarachnoid hemorrhage: relation to cerebral me-tabolism and outcome?. ### Response: Relationship betweenadmission hyperglycemia and neurologic outcome of severely brain-injured patients.


Instruction: How does systemic glucose and brain energy metabolism after subarachnoid hemorrhage affect the brain?

Output: relation to cerebral me-tabolism and outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does systemic glucose and brain energy metabolism after subarachnoid hemorrhage affect the brain?. ### Response: relation to cerebral me-tabolism and outcome.


Instruction: What is Giller CA, Wills MJ, Giller AM, Samson D?

Output: Distribution of hematocrit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Giller CA, Wills MJ, Giller AM, Samson D?. ### Response: Distribution of hematocrit.


Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al.


Instruction: What is the name of the guideline for management of vavular heart disease?

Output: ACC/AHA Guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the guideline for management of vavular heart disease?. ### Response: ACC/AHA Guideline.


Instruction: When did Otto and colleagues publish their guideline?

Output: 2020 ACC/AHA Guideline for the Management of Valvular Heart DiseaseCirculation. 2021;143:e72–e227. DOI: 10.1161/CIR.0000000000000923 February 2, 2021

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Otto and colleagues publish their guideline?. ### Response: 2020 ACC/AHA Guideline for the Management of Valvular Heart DiseaseCirculation. 2021;143:e72–e227. DOI: 10.1161/CIR.0000000000000923 February 2, 2021.


Instruction: What do Heart Valve Centers and 3) focus on?

Output: patient-centric care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do Heart Valve Centers and 3) focus on?. ### Response: patient-centric care.


Instruction: What is needed to assist cardiologists and patients to make well informed choices?

Output: More acces-sible quality and outcome data are also needed from Comprehensive Valve Centers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed to assist cardiologists and patients to make well informed choices?. ### Response: More acces-sible quality and outcome data are also needed from Comprehensive Valve Centers.


Instruction: What are the evidence gaps and future directions for patients with VHDE?

Output: vidence Gaps Future Directions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the evidence gaps and future directions for patients with VHDE?. ### Response: vidence Gaps Future Directions.


Instruction: Disease mechanisms Basic science to identify specific targets for medical therapy Rheumatic heart disease Primary and secondary prevention Calcific valve disease

Output: advanced imaging endpoints

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Disease mechanisms Basic science to identify specific targets for medical therapy Rheumatic heart disease Primary and secondary prevention Calcific valve disease. ### Response: advanced imaging endpoints.


Instruction: Disease Primary and secondary prevention Calcific valve disease Identification of patients at riskRisk factor interventionPrevention of disease initiationMedical therapy for progressive valve disease (Stage B) Disease mechanisms Basic science to identify specific targets to slow or reverse disease progression Medical intervention Targeted therapy using what?

Output: advanced imaging endpoints

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Disease Primary and secondary prevention Calcific valve disease Identification of patients at riskRisk factor interventionPrevention of disease initiationMedical therapy for progressive valve disease (Stage B) Disease mechanisms Basic science to identify specific targets to slow or reverse disease progression Medical intervention Targeted therapy using what?. ### Response: advanced imaging endpoints.


Instruction: What type of therapy is used to study disease mechanisms?

Output: Medical intervention Targeted therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is used to study disease mechanisms?. ### Response: Medical intervention Targeted therapy.


Instruction: What is the name of the stage of intervention?

Output: Stage C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the stage of intervention?. ### Response: Stage C.


Instruction: How is the timing of intervention determined?

Output: Validation of newer measures of LV size (eg, volumes instead of dimension) and function (eg, strain)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the timing of intervention determined?. ### Response: Validation of newer measures of LV size (eg, volumes instead of dimension) and function (eg, strain).


Instruction: What is Stage C?

Output: Optimal timing of intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Stage C?. ### Response: Optimal timing of intervention.


Instruction: What are newer measures of LV size and function used for?

Output: timing of intervention decisions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are newer measures of LV size and function used for?. ### Response: timing of intervention decisions.


Instruction: What is the name of the research that involves patients in identifying research questions?

Output: Patient-centered research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the research that involves patients in identifying research questions?. ### Response: Patient-centered research.


Instruction: What is asymptomatic severe AS with LV dysfunction?

Output: moderate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is asymptomatic severe AS with LV dysfunction?. ### Response: moderate.


Instruction: What type of research involves patients in identifying research questions, study design, and definition of outcomes?

Output: Patient-centered

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of research involves patients in identifying research questions, study design, and definition of outcomes?. ### Response: Patient-centered.


Instruction: What is appropriate representation of diverse patient populations in RCTs for VHD?

Output: Inclusion of diverse patient groups

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is appropriate representation of diverse patient populations in RCTs for VHD?. ### Response: Inclusion of diverse patient groups.


Instruction: Development and validation of improved decision aids for shared decision making with patients?

Output: Comprehensive Valve Centers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Development and validation of improved decision aids for shared decision making with patients?. ### Response: Comprehensive Valve Centers.


Instruction: What type of valves are more durable than TAVI valves?

Output: surgical and transcatheter valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of valves are more durable than TAVI valves?. ### Response: surgical and transcatheter valves.


Instruction: What kind of anticoagulation is better for mechanical valves than VKA?

Output: Optimal antithrombotic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What kind of anticoagulation is better for mechanical valves than VKA?. ### Response: Optimal antithrombotic therapy.


Instruction: How are decision aids used?

Output: shared decision-making with patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are decision aids used?. ### Response: shared decision-making with patients.


Instruction: What is an alternative to VKA anticoagulation for mechanical valves?

Output: Optimal antithrombotic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an alternative to VKA anticoagulation for mechanical valves?. ### Response: Optimal antithrombotic therapy.


Instruction: What type of therapy after TAVI Medical therapy after AVR Medical therapy to address ventricular and vascular function

Output: Optimal antithrombotic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy after TAVI Medical therapy after AVR Medical therapy to address ventricular and vascular function. ### Response: Optimal antithrombotic therapy.


Instruction: What does the National CholesterolEducation Program Adult Treatment Panel definition of the metabolicsyndrome apply to?

Output: Asians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the National CholesterolEducation Program Adult Treatment Panel definition of the metabolicsyndrome apply to?. ### Response: Asians.


Instruction: When did Diabetes Care. 2004:27:1182–6.452?

Output: 2004;27:1182–6.452. Buse JB, Ginsberg HN, Bakris GL, et al. Primary prevention of car-diovascular diseases in people with diabetes mellitus: a sc ientificstatement from the American Heart Association and the AmericanDiabetes Association. Circulation. 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Diabetes Care. 2004:27:1182–6.452?. ### Response: 2004;27:1182–6.452. Buse JB, Ginsberg HN, Bakris GL, et al. Primary prevention of car-diovascular diseases in people with diabetes mellitus: a sc ientificstatement from the American Heart Association and the AmericanDiabetes Association. Circulation. 2007.


Instruction: What is the primary prevention of car-diovascular diseases in people with diabetes mellitus?

Output: a sc ientificstatement from the American Heart Association and the AmericanDiabetes Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary prevention of car-diovascular diseases in people with diabetes mellitus?. ### Response: a sc ientificstatement from the American Heart Association and the AmericanDiabetes Association.


Instruction: What are the names of the two organizations that study diabetes in people with diabetes mellitus?

Output: American Heart Association and the AmericanDiabetes Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the two organizations that study diabetes in people with diabetes mellitus?. ### Response: American Heart Association and the AmericanDiabetes Association.


Instruction: What is the acronym for the Take Control of YourBlood pressure study?

Output: TCYB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the Take Control of YourBlood pressure study?. ### Response: TCYB.


Instruction: When was the United States Surgeon General’s Report released?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the United States Surgeon General’s Report released?. ### Response: 2004.


Instruction: What is the 2004 United States Surgeon General’s Report: The Health Con-sequences of Smoking?

Output: The Take Control of YourBlood pressure (TCYB) study: study design and methodology.Contemp Clin Trials. 2007;28:33–47.454. The 2004 United States Surgeon General’s Report: The Health Con-sequences of Smoking. N S W Public Health Bull. 2004;15:107.455

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2004 United States Surgeon General’s Report: The Health Con-sequences of Smoking?. ### Response: The Take Control of YourBlood pressure (TCYB) study: study design and methodology.Contemp Clin Trials. 2007;28:33–47.454. The 2004 United States Surgeon General’s Report: The Health Con-sequences of Smoking. N S W Public Health Bull. 2004;15:107.455.


Instruction: What is a systematic review of mortality risk reduction associated with smoking cessation in patients with coronary heart disease?

Output: JAMA. 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a systematic review of mortality risk reduction associated with smoking cessation in patients with coronary heart disease?. ### Response: JAMA. 2003.


Instruction: What are the standards of medical care in diabetes—2011?

Output: 34Suppl 1:S11–S61.457

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the standards of medical care in diabetes—2011?. ### Response: 34Suppl 1:S11–S61.457.


Instruction: What is the main result of the PREMIER clinical trial?

Output: Effects of compre-hensive lifestyle modification on blood pressure control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the main result of the PREMIER clinical trial?. ### Response: Effects of compre-hensive lifestyle modification on blood pressure control.


Instruction: How many participants participated in a meta-analysis of data from 26 randomised trials?

Output: 170 000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many participants participated in a meta-analysis of data from 26 randomised trials?. ### Response: 170 000.


Instruction: When did the Lancet 376:1670–81.459 publish?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Lancet 376:1670–81.459 publish?. ### Response: 2010.


Instruction: What is a risk factor for angina pectoris in the multisite cardiac lifestyle intervention program?

Output: atherosclerotic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for angina pectoris in the multisite cardiac lifestyle intervention program?. ### Response: atherosclerotic.


Instruction: What are the factors in the multisite cardiac lifestyle intervention program?

Output: Angina pectoris andatherosclerotic risk factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the factors in the multisite cardiac lifestyle intervention program?. ### Response: Angina pectoris andatherosclerotic risk factors.


Instruction: What is the name of the journal that published a study on major depression and medication adherence in elderly patients with coronary artery disease?

Output: Health Psychol.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that published a study on major depression and medication adherence in elderly patients with coronary artery disease?. ### Response: Health Psychol..


Instruction: Psychological interventions forcoronary heart disease.

Output: Rees K, Bennett P, West R, et al. Psychological interventions forcoronary heart disease. Cochrane Database Syst Rev. 2004;CD002902.462

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Psychological interventions forcoronary heart disease.. ### Response: Rees K, Bennett P, West R, et al. Psychological interventions forcoronary heart disease. Cochrane Database Syst Rev. 2004;CD002902.462.


Instruction: Cochrane Database Syst Rev. 2004;CD002902.462.

Output: Psychological interventions forcoronary heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cochrane Database Syst Rev. 2004;CD002902.462.. ### Response: Psychological interventions forcoronary heart disease.


Instruction: Patien ts withdepression are less likely to follow recommendations to reduce cardiacrisk during recovery from a myocardial infarction.

Output: 2902.462

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patien ts withdepression are less likely to follow recommendations to reduce cardiacrisk during recovery from a myocardial infarction.. ### Response: 2902.462.


Instruction: What is the name of the Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy (CREATE) tri al?

Output: Lesperance F, Frasure-Smith N, Koszycki D, et al. Effects of cita-lopram and interpersonal psychotherapy on depression in patients withcoronary artery disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy (CREATE) tri al?. ### Response: Lesperance F, Frasure-Smith N, Koszycki D, et al. Effects of cita-lopram and interpersonal psychotherapy on depression in patients withcoronary artery disease.


Instruction: When was the CREATE tri al published?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the CREATE tri al published?. ### Response: 2007.


Instruction: Whooley MA. Depression and cardiovascular disease: healing thebroken-hearted. JAMA. 2006;295:2874–81.468.

Output: withdepression are less likely to follow recommendations to reduce cardiacrisk during recovery from a myocardial infarction. Arch Intern Med.2000;160:1818–23.463. Lesperance F, Frasure-Smith N, Koszycki D, et al. Effects of cita-lopram and interpersonal psychotherapy on depression in patients withcoronary artery disease: the Canadian Cardiac Randomized Evaluationof Antidepressant and Psychotherapy Efficacy (CREATE) tri al.JAMA. 2007;297:367–79.464. McManus D, Pipkin SS, Whooley MA. Screening for depression inpatients with coronary heart disease (data from the Heart and SoulStudy). Am J Cardiol. 2005;96:1076–81.465. Deleted in proof.466. Deleted in proof.467

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Whooley MA. Depression and cardiovascular disease: healing thebroken-hearted. JAMA. 2006;295:2874–81.468.. ### Response: withdepression are less likely to follow recommendations to reduce cardiacrisk during recovery from a myocardial infarction. Arch Intern Med.2000;160:1818–23.463. Lesperance F, Frasure-Smith N, Koszycki D, et al. Effects of cita-lopram and interpersonal psychotherapy on depression in patients withcoronary artery disease: the Canadian Cardiac Randomized Evaluationof Antidepressant and Psychotherapy Efficacy (CREATE) tri al.JAMA. 2007;297:367–79.464. McManus D, Pipkin SS, Whooley MA. Screening for depression inpatients with coronary heart disease (data from the Heart and SoulStudy). Am J Cardiol. 2005;96:1076–81.465. Deleted in proof.466. Deleted in proof.467.


Instruction: Lichtman JH, Bigger JT Jr, Blumenthal JA, et al. What are the recommendations for Screening, Referral, and Treatment of Depression and Coronary Heart Disease?

Output: A Science Advisory

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Lichtman JH, Bigger JT Jr, Blumenthal JA, et al. What are the recommendations for Screening, Referral, and Treatment of Depression and Coronary Heart Disease?. ### Response: A Science Advisory.


Instruction: Depression and Coronary Heart Disease. Recommendations for Screening, Referral,and Treatment.

Output: 468

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Depression and Coronary Heart Disease. Recommendations for Screening, Referral,and Treatment.. ### Response: 468.


Instruction: Leiden Device Registry.Heart. 2009;95:715–720.20 What is a risk factor analysis of per-manent pacemaker infection?

Output: results of a large prospectivestudy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Leiden Device Registry.Heart. 2009;95:715–720.20 What is a risk factor analysis of per-manent pacemaker infection?. ### Response: results of a large prospectivestudy.


Instruction: What is the name of the study group that studied risk factors related to infections of implantedpacemakers and cardioverter-defibrillators?

Output: PEOPLE Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study group that studied risk factors related to infections of implantedpacemakers and cardioverter-defibrillators?. ### Response: PEOPLE Study Group.