Instruction: What remains the best option for the diagnosis of left main disease?

Output: angiographicdetermination of left main disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What remains the best option for the diagnosis of left main disease?. ### Response: angiographicdetermination of left main disease.


Instruction: What is the best option for the diagnosis and reevaluation of left main disease if there is concern about progression of previously diagnoseddisease?

Output: angiographicdetermination of left main disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the best option for the diagnosis and reevaluation of left main disease if there is concern about progression of previously diagnoseddisease?. ### Response: angiographicdetermination of left main disease.


Instruction: How many large studies in high-cardiovascular-risk patients showed cardiovascular protec-tive effects by ACE inhibitors?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many large studies in high-cardiovascular-risk patients showed cardiovascular protec-tive effects by ACE inhibitors?. ### Response: 2.


Instruction: How many studies in low-cardiovas-cular-risk people did not show cardiovascular pro-tective effects?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies in low-cardiovas-cular-risk people did not show cardiovascular pro-tective effects?. ### Response: 1.


Instruction: What trial randomized 25 620 patients?

Output: Ongoing Telmisartan Alone and In Combination with Ramipril Global Endpoint Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What trial randomized 25 620 patients?. ### Response: Ongoing Telmisartan Alone and In Combination with Ramipril Global Endpoint Trial.


Instruction: How many patients did the ONTARGET trial randomize?

Output: 25 620

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients did the ONTARGET trial randomize?. ### Response: 25 620.


Instruction: What percentage of the patients had a history of CAD?

Output: 74%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the patients had a history of CAD?. ### Response: 74%.


Instruction: How long did the median follow-up last?

Output: 4.7 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the median follow-up last?. ### Response: 4.7 years.


Instruction: How long was the median follow-up?

Output: 4.7 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the median follow-up?. ### Response: 4.7 years.


Instruction: What was the primary outcome of the 3 groups?

Output: cardiovascular death, nonfatal MI, non-fatal stroke, and hospitalization for HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary outcome of the 3 groups?. ### Response: cardiovascular death, nonfatal MI, non-fatal stroke, and hospitalization for HF.


Instruction: Which group had an increased risk of hypotensive symptoms, syncope and renal dysfunction?

Output: combination treatment group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which group had an increased risk of hypotensive symptoms, syncope and renal dysfunction?. ### Response: combination treatment group.


Instruction: Hypotensive symptoms, syncope, and renal dysfunction compared with those in the ramipril group?

Output: combination treatment group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hypotensive symptoms, syncope, and renal dysfunction compared with those in the ramipril group?. ### Response: combination treatment group.


Instruction: What did the investigators conclude had similar benefits?

Output: ramipril and telmisartan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the investigators conclude had similar benefits?. ### Response: ramipril and telmisartan.


Instruction: The combination of ACE inhibitor and ARB in this high-cardiovascular-risk group was associated with what?

Output: more side effects and no increase in benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The combination of ACE inhibitor and ARB in this high-cardiovascular-risk group was associated with what?. ### Response: more side effects and no increase in benefit.


Instruction: ARBs have been shown to reduce the incidence or severity of what?

Output: IHD events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ARBs have been shown to reduce the incidence or severity of what?. ### Response: IHD events.


Instruction: Angiotensin Receptor Blockers can reduce the progression of renal disease in what type of diabetes mellitus?

Output: type 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Angiotensin Receptor Blockers can reduce the progression of renal disease in what type of diabetes mellitus?. ### Response: type 2.


Instruction: What is considered an alternative therapy in individuals with cardiovascular disease?

Output: ARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is considered an alternative therapy in individuals with cardiovascular disease?. ### Response: ARBs.


Instruction: What is considered to be an alternative therapy in individuals with cardiovascular disease who are intolerant of ACE inhibitors?

Output: ARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is considered to be an alternative therapy in individuals with cardiovascular disease who are intolerant of ACE inhibitors?. ### Response: ARBs.


Instruction: In the Valsartan Antihypertensive Long-term Use Evaluation study, protection against a composite of cardiovascular events was similar to that observed for what drug?

Output: CCB amlodipine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the Valsartan Antihypertensive Long-term Use Evaluation study, protection against a composite of cardiovascular events was similar to that observed for what drug?. ### Response: CCB amlodipine.


Instruction: What was similar to that observed for the CCB amlodipine?

Output: protection against a composite of cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was similar to that observed for the CCB amlodipine?. ### Response: protection against a composite of cardiovascular events.


Instruction: In the early stages of the V ALUE trial, what may have confounded outcomes for MI and especially stroke?

Output: differences in BP control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the early stages of the V ALUE trial, what may have confounded outcomes for MI and especially stroke?. ### Response: differences in BP control.


Instruction: What was not shown in the Optimal Trial in Myocardial Infarction With the Angiotensin II Antagonist Losartan?

Output: Beneficial cardiovascular outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not shown in the Optimal Trial in Myocardial Infarction With the Angiotensin II Antagonist Losartan?. ### Response: Beneficial cardiovascular outcomes.


Instruction: The lack of ben-efit may have been attributable to inadequate doses of what?

Output: losar -tan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The lack of ben-efit may have been attributable to inadequate doses of what?. ### Response: losar -tan.


Instruction: What was the ARB valsartan had in the VALIANT trial?

Output: effects similar to those of the ACE inhibitor captopril in reducing cardiovascular event end points

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the ARB valsartan had in the VALIANT trial?. ### Response: effects similar to those of the ACE inhibitor captopril in reducing cardiovascular event end points.


Instruction: What was the name of the Acute Myocardial Infarction Trial?

Output: V ALIANT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the Acute Myocardial Infarction Trial?. ### Response: V ALIANT.


Instruction: The ARB valsartan had effects similar to those of what other ACE inhibitor?

Output: captopril

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The ARB valsartan had effects similar to those of what other ACE inhibitor?. ### Response: captopril.


Instruction: What did the ARB and ACE inhib-itor yield?

Output: an increase in adverse events with no incremental benefit for cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the ARB and ACE inhib-itor yield?. ### Response: an increase in adverse events with no incremental benefit for cardiovascular events.


Instruction: How long did the telmisartan trial last?

Output: 4.7 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the telmisartan trial last?. ### Response: 4.7 years.


Instruction: What was the median duration of the trial?

Output: 4.7 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the median duration of the trial?. ### Response: 4.7 years.


Instruction: How many high-risk patients had CAD?

Output: 75%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many high-risk patients had CAD?. ### Response: 75%.


Instruction: How long was the duration of the study?

Output: 4.7 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the duration of the study?. ### Response: 4.7 years.


Instruction: What was the mean BP in the telmisartan group?

Output: 4.0/2.2 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean BP in the telmisartan group?. ### Response: 4.0/2.2 mm Hg.


Instruction: Which group had a BP of 4.0/2.2 mm Hg lower than those randomized to placebo?

Output: telmisartan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which group had a BP of 4.0/2.2 mm Hg lower than those randomized to placebo?. ### Response: telmisartan.


Instruction: What would be saf e to star t statins aft er 48 hours?

Output: The consensus of t he committ ee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would be saf e to star t statins aft er 48 hours?. ### Response: The consensus of t he committ ee.


Instruction: Stroke and transient ischaemic attack in o ver 16s: diagnosis and initial management(NG128)?

Output: NICE 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Stroke and transient ischaemic attack in o ver 16s: diagnosis and initial management(NG128)?. ### Response: NICE 2023.


Instruction: What is NICE 2023?

Output: Stroke and transient ischaemic attack in o ver 16s: diagnosis and initial management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE 2023?. ### Response: Stroke and transient ischaemic attack in o ver 16s: diagnosis and initial management.


Instruction: What is the last updat ed 13 April 2022?

Output: Page 2 4of 48

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the last updat ed 13 April 2022?. ### Response: Page 2 4of 48.


Instruction: What was the name of the software developed by the GRADE working group?

Output: GRADEpro138

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the software developed by the GRADE working group?. ### Response: GRADEpro138.


Instruction: What was used to assess the quality of each outcome?

Output: GRADEpro138

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was used to assess the quality of each outcome?. ### Response: GRADEpro138.


Instruction: What is the name of each of the quality elements listed and defined in Table 2?

Output: Each outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of each of the quality elements listed and defined in Table 2?. ### Response: Each outcome.


Instruction: Who published the 2013 ACCF/AHA STEMI Guideline e405104?

Output: O’Gara et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2013 ACCF/AHA STEMI Guideline e405104?. ### Response: O’Gara et al.


Instruction: What is the name of the campaign to im-prove the timeliness of primary percutaneous coronary intervention?

Output: Door-to-Balloon: An Alliance for Quality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the campaign to im-prove the timeliness of primary percutaneous coronary intervention?. ### Response: Door-to-Balloon: An Alliance for Quality.


Instruction: Who joins the Door-to-Balloon Alliance for Quality?

Output: Bradley EH, Nallamothu BK, Stern AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who joins the Door-to-Balloon Alliance for Quality?. ### Response: Bradley EH, Nallamothu BK, Stern AF.


Instruction: When did Jt Comm J Qual Patient Saf. 2009:35:93–9.106?

Output: efforts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Jt Comm J Qual Patient Saf. 2009:35:93–9.106?. ### Response: efforts.


Instruction: What did Jacobs AK, Antman EM, Faxon DP, et al. develop?

Output: systems of care for ST-elevation myocardial infarction patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Jacobs AK, Antman EM, Faxon DP, et al. develop?. ### Response: systems of care for ST-elevation myocardial infarction patients.


Instruction: What is the name of the executive summary of care for ST-elevation myocardial infarction patients?

Output: Circulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the executive summary of care for ST-elevation myocardial infarction patients?. ### Response: Circulation.


Instruction: What does time is muscle: translation into practice?

Output: Antman EM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does time is muscle: translation into practice?. ### Response: Antman EM.


Instruction: Who is the author of Time is muscle?

Output: Antman EM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of Time is muscle?. ### Response: Antman EM.


Instruction: What is the name of the cardiac catheterization labora-tory for patients with ST-segment elevation myocardial infarc-tion?

Output: Door-to-Balloon

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the cardiac catheterization labora-tory for patients with ST-segment elevation myocardial infarc-tion?. ### Response: Door-to-Balloon.


Instruction: When did Lee CH, Van Gelder CM, Cone DC, perform cardiac catheterisation labo-ratory activation by paramedics?

Output: Early

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Lee CH, Van Gelder CM, Cone DC, perform cardiac catheterisation labo-ratory activation by paramedics?. ### Response: Early.


Instruction: What can paramedics read on prehospital 12-lead electrocardiograms?

Output: ST-segment eleva-tion myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can paramedics read on prehospital 12-lead electrocardiograms?. ### Response: ST-segment eleva-tion myocardial infarction.


Instruction: What is reduced in ST-elevation myocardial infarction by emergency medicine?

Output: Door-to-balloon times

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reduced in ST-elevation myocardial infarction by emergency medicine?. ### Response: Door-to-balloon times.


Instruction: How does emergency medicine reduce door-to-balloon times?

Output: immediate patient transfer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does emergency medicine reduce door-to-balloon times?. ### Response: immediate patient transfer.


Instruction: What is reduced in ST-elevation myocardial infarction by emergency physician activation of the cardiac catheterisation laboratory and immediate patient transfer?

Output: Door-to-balloon times

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reduced in ST-elevation myocardial infarction by emergency physician activation of the cardiac catheterisation laboratory and immediate patient transfer?. ### Response: Door-to-balloon times.


Instruction: What is compared to door-to-balloon times and false positive activations between emergency depart-ment and out-of-hospital activation?

Output: coronary catheterization team

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is compared to door-to-balloon times and false positive activations between emergency depart-ment and out-of-hospital activation?. ### Response: coronary catheterization team.


Instruction: What is the difference between emergency depart-ment and out-of-hospital activation of the coronary catheterization team?

Output: false-positive activations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between emergency depart-ment and out-of-hospital activation of the coronary catheterization team?. ### Response: false-positive activations.


Instruction: What are the rates of cardiac catheterization laboratory activation among patients with suspected ST-segment elevation myocardial infarction?

Output: False-positive

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the rates of cardiac catheterization laboratory activation among patients with suspected ST-segment elevation myocardial infarction?. ### Response: False-positive.


Instruction: What are the rates of cardiac catheterization cancelation for ST-segment elevation myocardial infarction after activa-tion by emergency medical services or emergency physicians?

Output: Rates of cardiac catheterization cancelation for ST-segment elevation myocardial infarction after activa-tion by emergency medical services or emergency physicians: results from the North Carolina Catheterization Laboratory Activation Registry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the rates of cardiac catheterization cancelation for ST-segment elevation myocardial infarction after activa-tion by emergency medical services or emergency physicians?. ### Response: Rates of cardiac catheterization cancelation for ST-segment elevation myocardial infarction after activa-tion by emergency medical services or emergency physicians: results from the North Carolina Catheterization Laboratory Activation Registry.


Instruction: What did the North Carolina Catheterization Laboratory Activation Registry do?

Output: Rates of cardiac catheterization cancelation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the North Carolina Catheterization Laboratory Activation Registry do?. ### Response: Rates of cardiac catheterization cancelation.


Instruction: What is the name of the study that optimizes electrocardiogram interpretation and clinical deci-sion-making for acute ST-elevation myocardial infarction?

Output: Appropriate cardiac cath lab ac-tivation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that optimizes electrocardiogram interpretation and clinical deci-sion-making for acute ST-elevation myocardial infarction?. ### Response: Appropriate cardiac cath lab ac-tivation.


Instruction: When was the Am Heart J.160 published?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Am Heart J.160 published?. ### Response: 2010.


Instruction: How many coronary artery bypass graft procedures are performed annually in the US?

Output: Nearly 400 000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many coronary artery bypass graft procedures are performed annually in the US?. ### Response: Nearly 400 000.


Instruction: How long has CABG been a proven therapy for?

Output: nearly 50 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long has CABG been a proven therapy for?. ### Response: nearly 50 years.


Instruction: What is the most durable and complete treatment of ischemic heart disease?

Output: coronary artery bypass graft surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most durable and complete treatment of ischemic heart disease?. ### Response: coronary artery bypass graft surgery.


Instruction: What do patients who underwent CABG remain at risk for after CABG?

Output: subsequent ischemic events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do patients who underwent CABG remain at risk for after CABG?. ### Response: subsequent ischemic events.


Instruction: What is CAD also known as?

Output: coronary artery disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CAD also known as?. ### Response: coronary artery disease.


Instruction: Secondary therapies play a key role in what?

Output: maintenance of native and graft vessel patency and in the prevention of adverse car -diovascular outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Secondary therapies play a key role in what?. ### Response: maintenance of native and graft vessel patency and in the prevention of adverse car -diovascular outcomes.


Instruction: What is a key role in the maintenance of native and graft vessel patency?

Output: Secondary therapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a key role in the maintenance of native and graft vessel patency?. ### Response: Secondary therapies.


Instruction: Postoperative antiplatelet agents and lipid-lowering therapy continue to be the mainstay of what?

Output: secondary prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Postoperative antiplatelet agents and lipid-lowering therapy continue to be the mainstay of what?. ### Response: secondary prevention.


Instruction: What are some of the opportunities for improving long-term clinical outcomes after CABG?

Output: aggressive management of hypertension and diabetes mellitus, smoking cessation, weight loss, and cardiac rehabilitation (CR).

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the opportunities for improving long-term clinical outcomes after CABG?. ### Response: aggressive management of hypertension and diabetes mellitus, smoking cessation, weight loss, and cardiac rehabilitation (CR)..


Instruction: What do secondary pre-ventive therapies help maintain?

Output: long-term graft patency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do secondary pre-ventive therapies help maintain?. ### Response: long-term graft patency.


Instruction: How do patients obtain the highest level of physical health and quality of life?

Output: Secondary pre-ventive therapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do patients obtain the highest level of physical health and quality of life?. ### Response: Secondary pre-ventive therapies.


Instruction: What does AHA stand for?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does AHA stand for?. ### Response: American Heart Association.


Instruction: What is the acronym for American College of Cardiology Foundation?

Output: ACCF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for American College of Cardiology Foundation?. ### Response: ACCF.


Instruction: In what year did the AHA publish a report on secondary prevention?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did the AHA publish a report on secondary prevention?. ### Response: 2011.


Instruction: What is used after surgical coronary revascularization?

Output: medical therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used after surgical coronary revascularization?. ### Response: medical therapy.


Instruction: What has emerged that further supports and broadens the merits of intensive risk-reduction therapies for CABG patients?

Output: important evidence from clinical and observational trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has emerged that further supports and broadens the merits of intensive risk-reduction therapies for CABG patients?. ### Response: important evidence from clinical and observational trials.


Instruction: What population is the focus of this scientific statement?

Output: CABG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What population is the focus of this scientific statement?. ### Response: CABG.


Instruction: What is the purpose of the scientific statement specifically focused on the CABG population?

Output: to thoroughly evaluate the current state of evidence on preventive therapies after surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of the scientific statement specifically focused on the CABG population?. ### Response: to thoroughly evaluate the current state of evidence on preventive therapies after surgery.


Instruction: After CABG, what highlights areas in need of prospectively collected clinical trial data?

Output: secondary preventive therapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: After CABG, what highlights areas in need of prospectively collected clinical trial data?. ### Response: secondary preventive therapies.


Instruction: What reduces risk as assessed by a variety of outcomes?

Output: Comprehensive risk factor management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What reduces risk as assessed by a variety of outcomes?. ### Response: Comprehensive risk factor management.


Instruction: What do healthcare providers implement in CABG patients?

Output: rec-ommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do healthcare providers implement in CABG patients?. ### Response: rec-ommendations.


Instruction: What is important to maximize the benefit to the patient?

Output: Secondary pre-ventive therapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is important to maximize the benefit to the patient?. ### Response: Secondary pre-ventive therapies.


Instruction: Where are clasifications of recommendations and levels of evidence expressed?

Output: AHA/ACCF format

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are clasifications of recommendations and levels of evidence expressed?. ### Response: AHA/ACCF format.


Instruction: What format are recommendations and levels of evidence expressed in?

Output: AHA/ACCF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What format are recommendations and levels of evidence expressed in?. ### Response: AHA/ACCF.


Instruction: Recommendations made herein are based largely on recent clinical and observational trials and major practice guide-lines previously published by the AHA/ACCF and what other organization?

Output: American College of Cardiology Foundation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Recommendations made herein are based largely on recent clinical and observational trials and major practice guide-lines previously published by the AHA/ACCF and what other organization?. ### Response: American College of Cardiology Foundation.


Instruction: On what date did the Council Scientific Statement Oversight Committee meet?

Output: January 19, 2021

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On what date did the Council Scientific Statement Oversight Committee meet?. ### Response: January 19, 2021.


Instruction: On what day was the American Heart Association Executive Committee meeting?

Output: April 12, 2021

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On what day was the American Heart Association Executive Committee meeting?. ### Response: April 12, 2021.


Instruction: Where is a copy of the document available?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is a copy of the document available?. ### Response: http://ahajournals.org.


Instruction: How do you search for guidelines and statements?

Output: Se-lect the “Guidelines & Statements” drop-down menu

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do you search for guidelines and statements?. ### Response: Se-lect the “Guidelines & Statements” drop-down menu.


Instruction: Who can purchase additional reprints?

Output: Meredith.Edelman@wolterskluwer.com

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who can purchase additional reprints?. ### Response: Meredith.Edelman@wolterskluwer.com.


Instruction: What does the American Heart Association request that this document be cited as?

Output: Kleindorfer DO, Towfighi A, Chaturvedi S, Cockroft KM, Gutierrez J, Lombardi-Hill D, Kamel H, Kernan WN, Kittner SJ, Leira EC, Lennon O, Meschia JF, Nguyen TN, Pollak PM, Santangeli P, Sharrief AZ, Smith SC Jr, Turan TN, Williams LS. 2021 Guideline for the prevention of stroke in patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the American Heart Association request that this document be cited as?. ### Response: Kleindorfer DO, Towfighi A, Chaturvedi S, Cockroft KM, Gutierrez J, Lombardi-Hill D, Kamel H, Kernan WN, Kittner SJ, Leira EC, Lennon O, Meschia JF, Nguyen TN, Pollak PM, Santangeli P, Sharrief AZ, Smith SC Jr, Turan TN, Williams LS. 2021 Guideline for the prevention of stroke in patients.


Instruction: What is the name of the area where a reprint of this article can be purchased?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the area where a reprint of this article can be purchased?. ### Response: http://ahajournals.org.


Instruction: Who can be reached to purchase additional copies of the article?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who can be reached to purchase additional copies of the article?. ### Response: American Heart Association.


Instruction: What is the 2021 guideline for the prevention of stroke in patients with stroke and transient ischemic attack?

Output: 2021 Guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2021 guideline for the prevention of stroke in patients with stroke and transient ischemic attack?. ### Response: 2021 Guideline.


Instruction: What is a guideline from the American Heart Associa-tion/American Stroke Association?

Output: Guideline for the prevention of stroke in patients with stroke and transient ischemic attack

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a guideline from the American Heart Associa-tion/American Stroke Association?. ### Response: Guideline for the prevention of stroke in patients with stroke and transient ischemic attack.


Instruction: Who conducts expert peer review of AHA-commissioned documents?

Output: AHA Office of Science Operations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who conducts expert peer review of AHA-commissioned documents?. ### Response: AHA Office of Science Operations.


Instruction: Where can you find more information on AHA statements and guidelines development?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find more information on AHA statements and guidelines development?. ### Response: https://professional.heart.org/statements.


Instruction: What is the name of the drop-down menu where you can select the AHA statement and guidelines?

Output: Guidelines & Statements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drop-down menu where you can select the AHA statement and guidelines?. ### Response: Guidelines & Statements.


Instruction: Who grants permission for multiple copies, modification, alteration, enhancement, and distribution of this document?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who grants permission for multiple copies, modification, alteration, enhancement, and distribution of this document?. ### Response: American Heart Association.


Instruction: Where are instructions for obtaining permission located?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are instructions for obtaining permission located?. ### Response: https://www.heart.org/permissions.


Instruction: Where is a link to the "Copyright Permissions Re-quest Form"?

Output: in the second paragraph

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is a link to the "Copyright Permissions Re-quest Form"?. ### Response: in the second paragraph.


Instruction: Who was a former member of the Stroke Scientific Statement Oversight Committee?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was a former member of the Stroke Scientific Statement Oversight Committee?. ### Response: *.


Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020 Page 43 of 127 Recommendation 18?

Output: For primary prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020 Page 43 of 127 Recommendation 18?. ### Response: For primary prevention.


Instruction: What is insufficient evidence to recommend for or against icosapent ethyl in patients on statin therapy?

Output: persistently elevated fasting triglycerides

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is insufficient evidence to recommend for or against icosapent ethyl in patients on statin therapy?. ### Response: persistently elevated fasting triglycerides.


Instruction: Patients on statin therapy with persistently elevated fasting triglycerides should take what for secondary prevention?

Output: icosapent ethyl

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients on statin therapy with persistently elevated fasting triglycerides should take what for secondary prevention?. ### Response: icosapent ethyl.


Instruction: What is icosapent ethyl meant to reduce?

Output: cardiovascular morbidity and mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is icosapent ethyl meant to reduce?. ### Response: cardiovascular morbidity and mortality.


Instruction: What is Icosapent ethy l purified from?

Output: omega- 3 fatty acid eicosapentaenoic acid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Icosapent ethy l purified from?. ### Response: omega- 3 fatty acid eicosapentaenoic acid.


Instruction: What is the omega-3 fatty acid EPA?

Output: eicosapentaenoic acid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the omega-3 fatty acid EPA?. ### Response: eicosapentaenoic acid.


Instruction: What was the body of evidence examining the potential effects of icosapent ethyl on critical CV outcomes limited to?

Output: a single randomized trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the body of evidence examining the potential effects of icosapent ethyl on critical CV outcomes limited to?. ### Response: a single randomized trial.


Instruction: What was limited to a single randomized trial?

Output: the body of evidence examining the potential effects of icosapent ethyl on critical CV outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was limited to a single randomized trial?. ### Response: the body of evidence examining the potential effects of icosapent ethyl on critical CV outcomes.


Instruction: Who conducted a double-blind, placebo -controlled trial in 2019?

Output: Bhatt et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who conducted a double-blind, placebo -controlled trial in 2019?. ### Response: Bhatt et al.


Instruction: What is REDUCE -IT?

Output: Reduction of Cardiovascular Events With Icosapent Ethyl -Intervention Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is REDUCE -IT?. ### Response: Reduction of Cardiovascular Events With Icosapent Ethyl -Intervention Trial.


Instruction: How much did treatment with 4 grams of icosapent ethyl result in?

Output: 25% reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much did treatment with 4 grams of icosapent ethyl result in?. ### Response: 25% reduction.


Instruction: What is the primary endpoint defined as?

Output: prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary endpoint defined as?. ### Response: prevention.


Instruction: How long did it take for a non- fatal stroke to occur?

Output: 4.9 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for a non- fatal stroke to occur?. ### Response: 4.9 years.


Instruction: What percentage of the subjects in the study were high risk patients?

Output: 70%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the subjects in the study were high risk patients?. ### Response: 70%.


Instruction: What percentage of the enrolled patients had a history of CVD?

Output: 70%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the enrolled patients had a history of CVD?. ### Response: 70%.


Instruction: What was a minority of the patients enrolled in the primary prevention cohort?

Output: patients without a history of atherosclerotic CVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a minority of the patients enrolled in the primary prevention cohort?. ### Response: patients without a history of atherosclerotic CVD.


Instruction: How did the Work Group determine that the REDUCE -IT results alone are insufficient to show a difference in CV outcomes?

Output: a subgroup analysis of the primary prevention cohort

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did the Work Group determine that the REDUCE -IT results alone are insufficient to show a difference in CV outcomes?. ### Response: a subgroup analysis of the primary prevention cohort.


Instruction: What are the results of REDUCE -IT insufficient to suggest?

Output: icosapent ethyl

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of REDUCE -IT insufficient to suggest?. ### Response: icosapent ethyl.


Instruction: What is applicable to many patients classified as high risk by virtue of a history of CVD?

Output: The results from REDUCE -IT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is applicable to many patients classified as high risk by virtue of a history of CVD?. ### Response: The results from REDUCE -IT.


Instruction: What percentage of patients had TG levels above 150 mg/dL?

Output: 90%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients had TG levels above 150 mg/dL?. ### Response: 90%.


Instruction: What was the median TG level in patients with CVD?

Output: 216 mg/dL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the median TG level in patients with CVD?. ### Response: 216 mg/dL.


Instruction: How much of the patients with TG were on medication?

Output: 90%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the patients with TG were on medication?. ### Response: 90%.


Instruction: What percentage of patients were on stable doses of moderate to high dose statins for at least four weeks before the intervention?

Output: 90%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients were on stable doses of moderate to high dose statins for at least four weeks before the intervention?. ### Response: 90%.


Instruction: What percentage reduction in CVD outcomes pertains to secondary prevention populations on statin therapy with hypertriglyceridemia?

Output: 25%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage reduction in CVD outcomes pertains to secondary prevention populations on statin therapy with hypertriglyceridemia?. ### Response: 25%.


Instruction: What was the composite outcome of statin therapy with hypertriglyceridemia?

Output: coronary revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the composite outcome of statin therapy with hypertriglyceridemia?. ### Response: coronary revascularization.


Instruction: What is a less clinically valid outcome for some patients?

Output: coronary revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a less clinically valid outcome for some patients?. ### Response: coronary revascularization.


Instruction: HBPM may help to improve what?

Output: patient motivation and adherence to treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: HBPM may help to improve what?. ### Response: patient motivation and adherence to treatment.


Instruction: What is strong evidence that home BP measurements are predictive of?

Output: long-term adverse clinical outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is strong evidence that home BP measurements are predictive of?. ### Response: long-term adverse clinical outcomes.


Instruction: What can HBPM help to improve?

Output: patient motivation and adherence to treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can HBPM help to improve?. ### Response: patient motivation and adherence to treatment.


Instruction: What can be used to identify patients with masked uncontrolled hypertension?

Output: HBPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be used to identify patients with masked uncontrolled hypertension?. ### Response: HBPM.


Instruction: What may require additional equipment, space, time, training, and/or change in culture, habits, or policies?

Output: The use of standardized of ﬁce measurements for BPmanagement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may require additional equipment, space, time, training, and/or change in culture, habits, or policies?. ### Response: The use of standardized of ﬁce measurements for BPmanagement.


Instruction: Practitioners would benefit from under-standing what?

Output: the guidelines and the underlying data and rationale

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Practitioners would benefit from under-standing what?. ### Response: the guidelines and the underlying data and rationale.


Instruction: What is essential for shared decision-making with individual patients?

Output: The practitioners should provide general information andindividualized considerations of the pros and cons of thetreatment option

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is essential for shared decision-making with individual patients?. ### Response: The practitioners should provide general information andindividualized considerations of the pros and cons of thetreatment option.


Instruction: Who should provide general information andindividualized consideration of the pros and cons of thetreatment option?

Output: The practitioners

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should provide general information andindividualized consideration of the pros and cons of thetreatment option?. ### Response: The practitioners.


Instruction: What are the pros and cons of thetreatment option?

Output: more certain in some groups (e.g., those whowould have been eligible for SPRINT) and less certain

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the pros and cons of thetreatment option?. ### Response: more certain in some groups (e.g., those whowould have been eligible for SPRINT) and less certain.


Instruction: What is the evidence for intensiveSBP targets less certain in some groups?

Output: proteinuria, diabetes, or older age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the evidence for intensiveSBP targets less certain in some groups?. ### Response: proteinuria, diabetes, or older age.


Instruction: People with diabetes, advanced CKD witheGFR30 ml/min per 1.73 m2, older adults aged >90 years and those with diabetes have what?

Output: severe hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: People with diabetes, advanced CKD witheGFR30 ml/min per 1.73 m2, older adults aged >90 years and those with diabetes have what?. ### Response: severe hypertension.


Instruction: How many m2 of older adults have hypertension?

Output: >90 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many m2 of older adults have hypertension?. ### Response: >90 years.


Instruction: What does the recommendation state that clinicians should target?

Output: an SBP <120 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the recommendation state that clinicians should target?. ### Response: an SBP <120 mm Hg.


Instruction: How many antihypertensive drugs do older adults take?

Output: >4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many antihypertensive drugs do older adults take?. ### Response: >4.


Instruction: What percentage of patients with CKD will have a SBP >120 mm Hg at any one time?

Output: 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients with CKD will have a SBP >120 mm Hg at any one time?. ### Response: 50%.


Instruction: What would a more stringent recommendation be that all patients should achieve?

Output: an SBP <120 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would a more stringent recommendation be that all patients should achieve?. ### Response: an SBP <120 mm Hg.


Instruction: What would require aneven lower target or threshold for intervention?

Output: all patientsshould achieve an SBP <120 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would require aneven lower target or threshold for intervention?. ### Response: all patientsshould achieve an SBP <120 mm Hg.


Instruction: What would gobeyond the available evidence?

Output: adoption of this more stringent recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would gobeyond the available evidence?. ### Response: adoption of this more stringent recommendation.


Instruction: The mean achieved SBP was what?

Output: 121.4 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The mean achieved SBP was what?. ### Response: 121.4 mm Hg.


Instruction: What replaces the target recommendations from Chapters 3 and 4 of the KDIGO 2012 recommenda-tion on BP management in CKD?

Output: SPRINT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What replaces the target recommendations from Chapters 3 and 4 of the KDIGO 2012 recommenda-tion on BP management in CKD?. ### Response: SPRINT.


Instruction: What are the most important differences?

Output: the adoption of standardized of ﬁcemeasurement as the preferred technique

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the most important differences?. ### Response: the adoption of standardized of ﬁcemeasurement as the preferred technique.


Instruction: What is the current guideline only an SBP target and not a DBP target?

Output: seebelow

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the current guideline only an SBP target and not a DBP target?. ### Response: seebelow.


Instruction: The recommendation of standardized of fice measurement is what?

Output: the preferred technique

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The recommendation of standardized of fice measurement is what?. ### Response: the preferred technique.


Instruction: What is a well-defined risk factor for subsequent infection?

Output: Nasal carriage of S. aureus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a well-defined risk factor for subsequent infection?. ### Response: Nasal carriage of S. aureus.


Instruction: What reduces the rate of nosocomialS. aureus infection in proven nasal carriers?

Output: intranasal mupirocin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What reduces the rate of nosocomialS. aureus infection in proven nasal carriers?. ### Response: intranasal mupirocin.


Instruction: What reduces the rate of nosocomialS. aureus infection?

Output: intranasal mupirocin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What reduces the rate of nosocomialS. aureus infection?. ### Response: intranasal mupirocin.


Instruction: What does intranasal mupirocin not reduce?

Output: the rate of surgicalsite infection with S. aureus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does intranasal mupirocin not reduce?. ### Response: the rate of surgicalsite infection with S. aureus.


Instruction: Preoperative patient bathing, the use of topical antiseptic skin cleansers and proper hair removal techniques are important measures of what?

Output: prepare the patient forsurgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Preoperative patient bathing, the use of topical antiseptic skin cleansers and proper hair removal techniques are important measures of what?. ### Response: prepare the patient forsurgery.


Instruction: What are two ways to prepare a patient for surgery?

Output: bath-ing, the use of topical antiseptic skin cleansers (chlorhexidinegluconate),930–932 and proper hair removal techniques

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are two ways to prepare a patient for surgery?. ### Response: bath-ing, the use of topical antiseptic skin cleansers (chlorhexidinegluconate),930–932 and proper hair removal techniques.


Instruction: What are three ways to decrease infection?

Output: adherence to sterile technique, minimization of operat-ing room traffic, less use of flash sterilization of surgicalinstruments, minimization of electrocautery933,936 and bonewax,938use of double-gloving,938–943 and shorter operativetimes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are three ways to decrease infection?. ### Response: adherence to sterile technique, minimization of operat-ing room traffic, less use of flash sterilization of surgicalinstruments, minimization of electrocautery933,936 and bonewax,938use of double-gloving,938–943 and shorter operativetimes.


Instruction: What type of wound infection occurs in 2% to 6% of patients after cardiac surgery?

Output: Superficial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of wound infection occurs in 2% to 6% of patients after cardiac surgery?. ### Response: Superficial.


Instruction: What is the mortality rate of deep sternal wound infection?

Output: 10% and 47%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the mortality rate of deep sternal wound infection?. ### Response: 10% and 47%..


Instruction: What is the etiology of deep sternal wound infection?

Output: multifac-torial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the etiology of deep sternal wound infection?. ### Response: multifac-torial.


Instruction: What are the risk factors for deep ternal wound infections?

Output: diabetes mellitus,25,27,28 obesity (body mass index /H1102230 kg/m2),947,949,950,953,954 chronic obstructive pulmonary disease,950prolonged CPB time, reoperation, prolonged intubation time,and surgical reexploration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the risk factors for deep ternal wound infections?. ### Response: diabetes mellitus,25,27,28 obesity (body mass index /H1102230 kg/m2),947,949,950,953,954 chronic obstructive pulmonary disease,950prolonged CPB time, reoperation, prolonged intubation time,and surgical reexploration.


Instruction: How long is CPB time?

Output: 950prolonged

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is CPB time?. ### Response: 950prolonged.


Instruction: What is a potential modifiable risk factor for deepsternal wound infection?

Output: smoking cessation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a potential modifiable risk factor for deepsternal wound infection?. ### Response: smoking cessation.


Instruction: What type of IMAs have been a subject of investigation as a risk factor?

Output: bilateral

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of IMAs have been a subject of investigation as a risk factor?. ### Response: bilateral.


Instruction: How much of the blood supply to each hemi-sternum does each IMA provide?

Output: 90%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the blood supply to each hemi-sternum does each IMA provide?. ### Response: 90%.


Instruction: What can compromise sternalwound healing?

Output: IMA harvesting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can compromise sternalwound healing?. ### Response: IMA harvesting.


Instruction: How have no RCTs assessed the risk of deepsternal wound infection?

Output: after bilateral IMA grafting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How have no RCTs assessed the risk of deepsternal wound infection?. ### Response: after bilateral IMA grafting.


Instruction: What increases the incidence of deep sternal woundinfection?

Output: the use of bilateral IMAs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What increases the incidence of deep sternal woundinfection?. ### Response: the use of bilateral IMAs.


Instruction: Skeletonization of the IMA may be associated with a beneficial reduction in what?

Output: the incidence of sternal woundcomplications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Skeletonization of the IMA may be associated with a beneficial reduction in what?. ### Response: the incidence of sternal woundcomplications.


Instruction: What is more evident in patients with diabetesmellitus?

Output: sternal woundcomplications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more evident in patients with diabetesmellitus?. ### Response: sternal woundcomplications.


Instruction: What is a risk factor for adverse outcomes after cardiac surgery?

Output: Transfusion of homologous blood

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for adverse outcomes after cardiac surgery?. ### Response: Transfusion of homologous blood.


Instruction: Blood transfusionsafter CABG are correlated in a dose-related fashion to an increased risk of what?

Output: transfusion-related infection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Blood transfusionsafter CABG are correlated in a dose-related fashion to an increased risk of what?. ### Response: transfusion-related infection.


Instruction: What is a lifestyle intervention for lowering blood pressure in patients with CKD not receiving dialysis?

Output: RAS inhibition

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a lifestyle intervention for lowering blood pressure in patients with CKD not receiving dialysis?. ### Response: RAS inhibition.


Instruction: What are the additional outcomes listed in Table 1?

Output: fat mass, BP, quality of life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the additional outcomes listed in Table 1?. ### Response: fat mass, BP, quality of life.


Instruction: Cochrane review Palmer SC, et al.

Output: Dietary interventions for adults with chronic kidney disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cochrane review Palmer SC, et al.. ### Response: Dietary interventions for adults with chronic kidney disease.


Instruction: What does exercise do in adults with CKD and hypertension?

Output: improve clinically relevant outcomes and decrease adverseeffects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does exercise do in adults with CKD and hypertension?. ### Response: improve clinically relevant outcomes and decrease adverseeffects.


Instruction: Does exercise improve clinical relevant outcomes and decrease adverseeffects?

Output: In adults with CKD and hypertension, does exercise improve clinically relevant outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Does exercise improve clinical relevant outcomes and decrease adverseeffects?. ### Response: In adults with CKD and hypertension, does exercise improve clinically relevant outcomes.


Instruction: How long is the duration of an exercise intervention?

Output: 8 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the duration of an exercise intervention?. ### Response: 8 weeks.


Instruction: What are the main outcomes of the RCT?

Output: fat mass, BP, quality of life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the main outcomes of the RCT?. ### Response: fat mass, BP, quality of life.


Instruction: Who wrote Exercise training for adults with chronic kidney disease (Review)?

Output: Heiwe S and Jacobson SH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote Exercise training for adults with chronic kidney disease (Review)?. ### Response: Heiwe S and Jacobson SH.


Instruction: What is the Cochrane Database of Systematic Reviews?

Output: 2006:4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Cochrane Database of Systematic Reviews?. ### Response: 2006:4.


Instruction: How is blood pressure managed in patients with CKD?

Output: lower (intensive) BP targets

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is blood pressure managed in patients with CKD?. ### Response: lower (intensive) BP targets.


Instruction: What does lower BP targets do in patients with CKD?

Output: improve clinical ef ﬁcacyoutcomes and reduce adverse effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does lower BP targets do in patients with CKD?. ### Response: improve clinical ef ﬁcacyoutcomes and reduce adverse effects.


Instruction: What does lowering BP target compared to standard BP goals improve?

Output: clinical ef ﬁcacyoutcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does lowering BP target compared to standard BP goals improve?. ### Response: clinical ef ﬁcacyoutcomes.


Instruction: What are the two types of diabetes?

Output: T1D and T2D

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the two types of diabetes?. ### Response: T1D and T2D.


Instruction: What is the difference between the lower and lower BP targets?

Output: <140/80 mm Hg, <130/80

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between the lower and lower BP targets?. ### Response: <140/80 mm Hg, <130/80.


Instruction: Where are the critical and important outcomes listed?

Output: Table 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are the critical and important outcomes listed?. ### Response: Table 1.


Instruction: What does RAS inhibition compared to placebo/no treatment or standard of care do in patients with CKD?

Output: improve clinicalefﬁcacy outcomes and reduce adverse effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does RAS inhibition compared to placebo/no treatment or standard of care do in patients with CKD?. ### Response: improve clinicalefﬁcacy outcomes and reduce adverse effects.


Instruction: What is CKD G1 – G5 without kidney transplant?

Output: Adults with CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CKD G1 – G5 without kidney transplant?. ### Response: Adults with CKD.


Instruction: What are ACEi, ARB, aldosterone antagonists used for?

Output: Intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are ACEi, ARB, aldosterone antagonists used for?. ### Response: Intervention.


Instruction: What are converting enzyme inhibitors and angiotensin II receptor antagonists for?

Output: preventing theprogression of diabetic kidney disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are converting enzyme inhibitors and angiotensin II receptor antagonists for?. ### Response: preventing theprogression of diabetic kidney disease.


Instruction: What is preventing the progression of diabetic kidney disease?

Output: Angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is preventing the progression of diabetic kidney disease?. ### Response: Angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists.


Instruction: When was the Cochrane Database of Systematic Reviews published?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Cochrane Database of Systematic Reviews published?. ### Response: 2011.


Instruction: What is the name of the Cochrane Database of Systematic Reviews?

Output: 2017:4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Cochrane Database of Systematic Reviews?. ### Response: 2017:4.


Instruction: What is renin angiotensin system antagonist?

Output: Aldosterone antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is renin angiotensin system antagonist?. ### Response: Aldosterone antagonists.


Instruction: IOM Standards for Systematic Reviews Part of the KDIGO Process?

Output: 2.6.10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: IOM Standards for Systematic Reviews Part of the KDIGO Process?. ### Response: 2.6.10.


Instruction: What does 2.6.10 describe and justify any planned analyses of differential treatment effects according to patient subgroups?

Output: IOM Standards for Systematic Reviews

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does 2.6.10 describe and justify any planned analyses of differential treatment effects according to patient subgroups?. ### Response: IOM Standards for Systematic Reviews.


Instruction: What is the timetable for conducting the review?

Output: 2.7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the timetable for conducting the review?. ### Response: 2.7.


Instruction: Submit the protocol for peer review No 2.7.1 Provide a public comment period for the protoc ol and publicly report on disposition of comments No 2.8 Make the final protocol publicly available and add any amendments to the protocol in a timely fashion?

Output: Describe the proposed timetable for conducting the review Yes 2.7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Submit the protocol for peer review No 2.7.1 Provide a public comment period for the protoc ol and publicly report on disposition of comments No 2.8 Make the final protocol publicly available and add any amendments to the protocol in a timely fashion?. ### Response: Describe the proposed timetable for conducting the review Yes 2.7.


Instruction: How do you add amendments to the protocol in a timely fashion?

Output: Make the final protocol publicly available

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do you add amendments to the protocol in a timely fashion?. ### Response: Make the final protocol publicly available.


Instruction: What type of search does a librarian or other information specia list trained in performing systematic reviews do?

Output: to plan the search strategy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of search does a librarian or other information specia list trained in performing systematic reviews do?. ### Response: to plan the search strategy.


Instruction: How does the search strategy address each key issue?

Output: Design

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does the search strategy address each key issue?. ### Response: Design.


Instruction: What type of librarian or other information specialist can peer review the search strategy?

Output: independent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of librarian or other information specialist can peer review the search strategy?. ### Response: independent.


Instruction: Search bibliographic databases Yes 3.1.5 Search citation indexes Yes 3.1.6 Search literature cited by eligible studies Yes 3.1.7 Search literature cit ed by what studies?

Output: eligible studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Search bibliographic databases Yes 3.1.5 Search citation indexes Yes 3.1.6 Search literature cited by eligible studies Yes 3.1.7 Search literature cit ed by what studies?. ### Response: eligible studies.


Instruction: 3.1.6 Search literature cit ed by eligible studies No 3.1.7 Update the search at intervals appropriate to the pace of generation of new information for the research question being addressed Yes 3.1.8 Search subject-specific databases if other databas es are unlikely to provide all relevant evidence N/A 3.1.9 Search regional databases?

Output: Search bibliographic databases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: 3.1.6 Search literature cit ed by eligible studies No 3.1.7 Update the search at intervals appropriate to the pace of generation of new information for the research question being addressed Yes 3.1.8 Search subject-specific databases if other databas es are unlikely to provide all relevant evidence N/A 3.1.9 Search regional databases?. ### Response: Search bibliographic databases.


Instruction: What do you do if other databases are unlikely to provide all relevant evidence N/A 3.1.9 Search regional bibliographic databases?

Output: Search subject-specific databases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do you do if other databases are unlikely to provide all relevant evidence N/A 3.1.9 Search regional bibliographic databases?. ### Response: Search subject-specific databases.


Instruction: Take action to address potentially biased reporting of research results No 3.2.1 Search grey-literature databases, clinical trial registries and other sources of what?

Output: unpublished information about studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Take action to address potentially biased reporting of research results No 3.2.1 Search grey-literature databases, clinical trial registries and other sources of what?. ### Response: unpublished information about studies.


Instruction: What should researchers clarify about study eligibility, study characteristics, and risk of bias?

Output: Invite researchers to clarify information

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should researchers clarify about study eligibility, study characteristics, and risk of bias?. ### Response: Invite researchers to clarify information.


Instruction: What should all study sponsors and researchers submit for possible inclusion in the systematic review?

Output: unpublished data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should all study sponsors and researchers submit for possible inclusion in the systematic review?. ### Response: unpublished data.


Instruction: What is included in a systematic review?

Output: unreported outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is included in a systematic review?. ### Response: unreported outcomes.


Instruction: What is a possible inclusion in the systematic review No 3.2.4 Handsearch selected journal s and conference abstracts No 3.2.5 Conduct a web search No 3.2.6 Search for studies reported in languages other than English if appropriate?

Output: Invite all study sponsors and researchers to submit unpublished data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a possible inclusion in the systematic review No 3.2.4 Handsearch selected journal s and conference abstracts No 3.2.5 Conduct a web search No 3.2.6 Search for studies reported in languages other than English if appropriate?. ### Response: Invite all study sponsors and researchers to submit unpublished data.


Instruction: How many members of a review team can work independently?

Output: two or more

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many members of a review team can work independently?. ### Response: two or more.


Instruction: What type of studies can be used to evaluate harms of interventions?

Output: observational studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of studies can be used to evaluate harms of interventions?. ### Response: observational studies.


Instruction: How many members of the review team work independently to screen and select studies?

Output: two or more

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many members of the review team work independently to screen and select studies?. ### Response: two or more.


Instruction: How do screeners train screeners?

Output: using written documentation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do screeners train screeners?. ### Response: using written documentation.


Instruction: What does screeners do to improve accuracy and consistency?

Output: test and retest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does screeners do to improve accuracy and consistency?. ### Response: test and retest.


Instruction: How many fulltext articles were identified in the search?

Output: all

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many fulltext articles were identified in the search?. ### Response: all.


Instruction: How many screen titles and abstracts of all articles were found in the initial screening?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many screen titles and abstracts of all articles were found in the initial screening?. ### Response: 2.


Instruction: What is the risk of bias?

Output: study eligibility, study characteristics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of bias?. ### Response: study eligibility, study characteristics.


Instruction: What type of studies can be used to address gaps in the data?

Output: observational

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of studies can be used to address gaps in the data?. ### Response: observational.


Instruction: What is the consensus panel guide to comprehensive risk reduction for adult patients without coronary or other atherosclerotic vascular diseases?

Output: AHA guidelines for primary prevention of cardiovascular disease and stroke: 2002 update

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the consensus panel guide to comprehensive risk reduction for adult patients without coronary or other atherosclerotic vascular diseases?. ### Response: AHA guidelines for primary prevention of cardiovascular disease and stroke: 2002 update.


Instruction: What is Bibbins-Domingo K's profession?

Output: US Preventive Services Task Force

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Bibbins-Domingo K's profession?. ### Response: US Preventive Services Task Force.


Instruction: What is the US Preventive Services Task Force Recommendation Statement for?

Output: primary prevention of cardiovascular disease and colorec-tal cancer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the US Preventive Services Task Force Recommendation Statement for?. ### Response: primary prevention of cardiovascular disease and colorec-tal cancer.


Instruction: What is a primary prevention of cardiovascular disease and colorec-tal cancer?

Output: Aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a primary prevention of cardiovascular disease and colorec-tal cancer?. ### Response: Aspirin.


Instruction: When was the Ann Intern Med164:836-45?

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Ann Intern Med164:836-45?. ### Response: 2016.


Instruction: What is the name of the study using aspirin to reduce risk of initial vascular events in patients at moderate risk of cardiovascular disease?

Output: ARRIVE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study using aspirin to reduce risk of initial vascular events in patients at moderate risk of cardiovascular disease?. ### Response: ARRIVE.


Instruction: What is ARRIVE?

Output: a randomised, double-blind, pla-cebo-controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ARRIVE?. ### Response: a randomised, double-blind, pla-cebo-controlled trial.


Instruction: At moderate risk of cardiovascular disease (ARRIVE): a randomised, double-blind, pla-cebo-controlled trial?

Output: Use of aspirin to reduce risk of initial vascular events in patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: At moderate risk of cardiovascular disease (ARRIVE): a randomised, double-blind, pla-cebo-controlled trial?. ### Response: Use of aspirin to reduce risk of initial vascular events in patients.


Instruction: In what year did the Lancet publish a report on ARRIVE?

Output: 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did the Lancet publish a report on ARRIVE?. ### Response: 2018.


Instruction: What is the scientific state-ment of the American Heart Association?

Output: Aspirin for primary pre-vention of cardiovascular events in people with diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the scientific state-ment of the American Heart Association?. ### Response: Aspirin for primary pre-vention of cardiovascular events in people with diabetes.


Instruction: What is a scientific statement of the American Heart Association?

Output: Value of primordial and primary prevention for cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a scientific statement of the American Heart Association?. ### Response: Value of primordial and primary prevention for cardiovascular disease.


Instruction: What is an expert consen-sus document of?

Output: American College of Cardiology Foundation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an expert consen-sus document of?. ### Response: American College of Cardiology Foundation.


Instruction: Which journal published a position paper on aspirin therapy in pri-mary cardiovascular disease prevention?

Output: European Society of Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which journal published a position paper on aspirin therapy in pri-mary cardiovascular disease prevention?. ### Response: European Society of Cardiology.


Instruction: What is a position paper of the European Society of Cardiology working group on thrombosis?

Output: Aspirin therapy in pri-mary cardiovascular disease prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a position paper of the European Society of Cardiology working group on thrombosis?. ### Response: Aspirin therapy in pri-mary cardiovascular disease prevention.


Instruction: When did the J Am Coll Cardiol. 2014:64:319–27?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the J Am Coll Cardiol. 2014:64:319–27?. ### Response: 2014.


Instruction: What is Aspirin for primary prevention of atherosclerotic cardiovascular disease?

Output: advances in diagnosis and treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Aspirin for primary prevention of atherosclerotic cardiovascular disease?. ### Response: advances in diagnosis and treatment.


Instruction: What is used to guide aspirin utilization for primary preven-tion?

Output: coronary artery calcium testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used to guide aspirin utilization for primary preven-tion?. ### Response: coronary artery calcium testing.


Instruction: What is the name of the multi-ethnic study of atherosclerosis?

Output: Miedema MD, Duprez DA, Misialek JR, et al. Use of coronary artery calcium testing to guide aspirin utilization for primary preven-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multi-ethnic study of atherosclerosis?. ### Response: Miedema MD, Duprez DA, Misialek JR, et al. Use of coronary artery calcium testing to guide aspirin utilization for primary preven-tion.


Instruction: When did Circ Cardiovasc Qual Outcomes publish?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circ Cardiovasc Qual Outcomes publish?. ### Response: 2014.


Instruction: What are the risks of vascular events and cancer according to bodyweight and dose?

Output: Effects of aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the risks of vascular events and cancer according to bodyweight and dose?. ### Response: Effects of aspirin.


Instruction: What is the name of the study that examined individual patient data from randomised trials?

Output: Lancet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined individual patient data from randomised trials?. ### Response: Lancet.


Instruction: When should aspirin be used for primary prevention?

Output: post-statin Era

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When should aspirin be used for primary prevention?. ### Response: post-statin Era.


Instruction: What is the post-statin era?

Output: primary prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the post-statin era?. ### Response: primary prevention.


Instruction: What are the costs and value considerations?

Output: S5-1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the costs and value considerations?. ### Response: S5-1.


Instruction: Who has a policy state-ment for primordial and primary prevention for cardiovascular disease?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who has a policy state-ment for primordial and primary prevention for cardiovascular disease?. ### Response: American Heart Association.


Instruction: What is the name of the Task Force on Performance Measures and Practice Guidelines?

Output: American College of Cardiology/American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Performance Measures and Practice Guidelines?. ### Response: American College of Cardiology/American Heart Association.


Instruction: What is a statement for healthcare profesionals from the American Heart Association/American Stroke Association?

Output: Management of Spontaneous ICH  2059Palliative and end-of-life care in stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a statement for healthcare profesionals from the American Heart Association/American Stroke Association?. ### Response: Management of Spontaneous ICH  2059Palliative and end-of-life care in stroke.


Instruction: What is the name of the study that addresses end-of-life care in stroke?

Output: Hemphill et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that addresses end-of-life care in stroke?. ### Response: Hemphill et al.


Instruction: How many strokes were there between 1887 and 1916?

Output: 260

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes were there between 1887 and 1916?. ### Response: 260.


Instruction: What may withdrawal of support in intrace-rebral hemorrhage lead to?

Output: self-fulfilling prophecies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may withdrawal of support in intrace-rebral hemorrhage lead to?. ### Response: self-fulfilling prophecies.


Instruction: What may lead to self-fulfilling prophecies?

Output: Withdrawal of support in intrace-rebral hemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may lead to self-fulfilling prophecies?. ### Response: Withdrawal of support in intrace-rebral hemorrhage.


Instruction: Who is Hemphill JC 3rd, Newman J, Zhao S, Johnston SC?

Output: White DB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Hemphill JC 3rd, Newman J, Zhao S, Johnston SC?. ### Response: White DB.


Instruction: What does early care limitations inde-pendently predict after intracerebral hemorrhage?

Output: mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does early care limitations inde-pendently predict after intracerebral hemorrhage?. ### Response: mortality.


Instruction: What is the doi: 10.1161/01.STR.0000125858. 71051.ca. 263. Mirski MA, Chang CW, Cowan R. Impact of a neuroscience study on mortality?

Output: Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the doi: 10.1161/01.STR.0000125858. 71051.ca. 263. Mirski MA, Chang CW, Cowan R. Impact of a neuroscience study on mortality?. ### Response: Stroke.


Instruction: What is the impact of a neuroscience intensive care unit on neurosurgical patient outcomes and cost of care?

Output: evidence-based support for an intensivist-directed specialty ICU model of care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact of a neuroscience intensive care unit on neurosurgical patient outcomes and cost of care?. ### Response: evidence-based support for an intensivist-directed specialty ICU model of care.


Instruction: What did Mirski MA, Chang CW, Cowan R. write about?

Output: Impact of a neuroscience intensive care unit on neurosurgical patient outcomes and cost of care: evidence-based support for an intensivist-directed specialty ICU model of care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Mirski MA, Chang CW, Cowan R. write about?. ### Response: Impact of a neuroscience intensive care unit on neurosurgical patient outcomes and cost of care: evidence-based support for an intensivist-directed specialty ICU model of care.


Instruction: What are do-not-attempt-resuscitation orders and prognostic models for for intraparenchymal hemorrhage?

Output: early

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are do-not-attempt-resuscitation orders and prognostic models for for intraparenchymal hemorrhage?. ### Response: early.


Instruction: Crit Care Med. 2011;39:158-162. doi: 10.1097/CCM.0b013e3181fb7b49.

Output: 265

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Crit Care Med. 2011;39:158-162. doi: 10.1097/CCM.0b013e3181fb7b49.. ### Response: 265.


Instruction: What does Hemphill JC 3rd, White DB do after intracerebral hemorrhage?

Output: Do-not-resuscitate orders and predictive models

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Hemphill JC 3rd, White DB do after intracerebral hemorrhage?. ### Response: Do-not-resuscitate orders and predictive models.