Instruction: What is thrombosis in vasculitis: from pathogenesis to treatment?

Output: Thrombosis in vas-culitis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is thrombosis in vasculitis: from pathogenesis to treatment?. ### Response: Thrombosis in vas-culitis.


Instruction: Who led the independentEvidence Review Team?

Output: Jonathan Craig

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who led the independentEvidence Review Team?. ### Response: Jonathan Craig.


Instruction: Who was the first Guideline Methods Chair of KDIGO?

Output: Marcello Tonelli

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the first Guideline Methods Chair of KDIGO?. ### Response: Marcello Tonelli.


Instruction: Who was KDIGO's first Guideline Methods Chair?

Output: Marcello Tonelli

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was KDIGO's first Guideline Methods Chair?. ### Response: Marcello Tonelli.


Instruction: What was Tonelli's job?

Output: Guideline Methods Chair

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was Tonelli's job?. ### Response: Guideline Methods Chair.


Instruction: How did MAGICapp help improve guideline methodology?

Output: generation of patientdecision aids directly from the evidence syntheses used tosupport the guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did MAGICapp help improve guideline methodology?. ### Response: generation of patientdecision aids directly from the evidence syntheses used tosupport the guideline.


Instruction: What platform did Dr. Tonelli suggest KDIGO use?

Output: MAGICapp

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What platform did Dr. Tonelli suggest KDIGO use?. ### Response: MAGICapp.


Instruction: What does MAGICapp allow for?

Output: direct linkage of the evidence tothe recommendation statement, and the generation of patientdecision aids directly from the evidence syntheses used tosupport the guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does MAGICapp allow for?. ### Response: direct linkage of the evidence tothe recommendation statement, and the generation of patientdecision aids directly from the evidence syntheses used tosupport the guideline.


Instruction: How does the program use the prede finedformat?

Output: allows for both direct linkage of the evidence tothe recommendation statement, and the generation of patientdecision aids directly from the evidence syntheses used tosupport the guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does the program use the prede finedformat?. ### Response: allows for both direct linkage of the evidence tothe recommendation statement, and the generation of patientdecision aids directly from the evidence syntheses used tosupport the guideline.


Instruction: What new form of guidance did he introduce in addition to recommendations?

Output: practice points

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What new form of guidance did he introduce in addition to recommendations?. ### Response: practice points.


Instruction: What was used to provide guidance in cases where systematic review was not done?

Output: a practicepoint

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was used to provide guidance in cases where systematic review was not done?. ### Response: a practicepoint.


Instruction: What was used to provide guidance to clinicians to warrant a recommendation?

Output: a practicepoint

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was used to provide guidance to clinicians to warrant a recommendation?. ### Response: a practicepoint.


Instruction: Practicepoints do not necessarily follow the same format as what?

Output: recom-mendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Practicepoints do not necessarily follow the same format as what?. ### Response: recom-mendations.


Instruction: How has KDIGO aligned the Blood Pressure in CKDGuideline with the current state of the evidence?

Output: update

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How has KDIGO aligned the Blood Pressure in CKDGuideline with the current state of the evidence?. ### Response: update.


Instruction: Who discussed the update to the KDIGO guidelineformat in greater detail?

Output: Dr. Tonelli

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who discussed the update to the KDIGO guidelineformat in greater detail?. ### Response: Dr. Tonelli.


Instruction: Who is confident that this guideline will prove useful to clinicians around the world?

Output: colleagues from the independentEvidence Review Team (ERT) led by Jonathan Craig, MBChB,DipCH, FRACP, M Med (Clin Epi), PhD; Martin Howell,PhD; and David Tunnicliffe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is confident that this guideline will prove useful to clinicians around the world?. ### Response: colleagues from the independentEvidence Review Team (ERT) led by Jonathan Craig, MBChB,DipCH, FRACP, M Med (Clin Epi), PhD; Martin Howell,PhD; and David Tunnicliffe.


Instruction: What will prove useful to clinicians around the world who are treating people with high BP and kidney disease?

Output: KDIGO guidelineformat is discussed below in greater detail by Dr. Tonelli(Figure 1 ).In summary, we are con ﬁdent that this guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will prove useful to clinicians around the world who are treating people with high BP and kidney disease?. ### Response: KDIGO guidelineformat is discussed below in greater detail by Dr. Tonelli(Figure 1 ).In summary, we are con ﬁdent that this guideline.


Instruction: Who did Michel Jadoul, MD, ScDKDIGO Co-Chair?

Output: Wolfgang C. Winkelmayer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who did Michel Jadoul, MD, ScDKDIGO Co-Chair?. ### Response: Wolfgang C. Winkelmayer.


Instruction: What is the primary efficacy endpoint for thrombolysis in myocardial infarction?

Output: cardiovas-cular death, nonfatal MI, or nonfatal stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary efficacy endpoint for thrombolysis in myocardial infarction?. ### Response: cardiovas-cular death, nonfatal MI, or nonfatal stroke.


Instruction: Prasugrel and clopidogrel have an increasedrisk of what?

Output: bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Prasugrel and clopidogrel have an increasedrisk of what?. ### Response: bleeding.


Instruction: What has not been conducted in clinical trials in patients withSIHD?

Output: prasugrel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has not been conducted in clinical trials in patients withSIHD?. ### Response: prasugrel.


Instruction: What drug has not been tested or approved for use in patients with SIHD?

Output: Ticagrelor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug has not been tested or approved for use in patients with SIHD?. ### Response: Ticagrelor.


Instruction: What is Ticagrelor a newly approved agent that has been shown to be beneficial inpatients with ACS but not tested in?

Output: patients withSIHD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Ticagrelor a newly approved agent that has been shown to be beneficial inpatients with ACS but not tested in?. ### Response: patients withSIHD.


Instruction: What is the name of the thienopyridine derivative that inhibitsplatelet aggregation but compares less favorably to clopi-dogrel as an alternative to aspirin?

Output: Ticlopidine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the thienopyridine derivative that inhibitsplatelet aggregation but compares less favorably to clopi-dogrel as an alternative to aspirin?. ### Response: Ticlopidine.


Instruction: What is the name of the pyrimido-pyrimidine derivative that pos-esses antiplatelet effects but does not have a proven role inpatients with SIHD?

Output: dipyridamole

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the pyrimido-pyrimidine derivative that pos-esses antiplatelet effects but does not have a proven role inpatients with SIHD?. ### Response: dipyridamole.


Instruction: What was not clearly superior to aspirin alone in the PARIS study?

Output: The combination of aspirin and dipyri-damole

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not clearly superior to aspirin alone in the PARIS study?. ### Response: The combination of aspirin and dipyri-damole.


Instruction: What does PARIS stand for?

Output: Persantine-Aspirin ReinfarctionStudy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does PARIS stand for?. ### Response: Persantine-Aspirin ReinfarctionStudy.


Instruction: Why is dipyridamole not recommended for secondary prevention inpatients with SIHD?

Output: vasodilates coronary resis-tance vessels and can provoke exercise-induced myocardialischemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is dipyridamole not recommended for secondary prevention inpatients with SIHD?. ### Response: vasodilates coronary resis-tance vessels and can provoke exercise-induced myocardialischemia.


Instruction: What can be disturbed in patients with IHD due toactivation of the extrinsic coagulation pathway?

Output: Fibrinolytic function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be disturbed in patients with IHD due toactivation of the extrinsic coagulation pathway?. ### Response: Fibrinolytic function.


Instruction: IHD is related toactivation of what pathway?

Output: extrinsic coagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: IHD is related toactivation of what pathway?. ### Response: extrinsic coagulation.


Instruction: What pathway leads toformation of thrombin?

Output: extrinsic coagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What pathway leads toformation of thrombin?. ### Response: extrinsic coagulation.


Instruction: Thrombin generates what?

Output: fibrin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Thrombin generates what?. ### Response: fibrin.


Instruction: What is antithrombotic therapy in patients with SIHD?

Output: Oral Anticoagulant Therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is antithrombotic therapy in patients with SIHD?. ### Response: Oral Anticoagulant Therapy.


Instruction: What did a systematic review of randomized trials of oralanticoagulants with and without antiplatelet therapy fail to provide?

Output: evi-dence of benefit from anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a systematic review of randomized trials of oralanticoagulants with and without antiplatelet therapy fail to provide?. ### Response: evi-dence of benefit from anticoagulation.


Instruction: How many patients with IHD were randomized?

Output: 20 000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with IHD were randomized?. ### Response: 20 000.


Instruction: What is evidence that individuals with defects in the coagulation system are at higher risk ofcardiac events?

Output: there is no evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is evidence that individuals with defects in the coagulation system are at higher risk ofcardiac events?. ### Response: there is no evidence.


Instruction: What should not be given to individuals solely to prevent such events? What should be used to prevent cardiac events in individuals?

Output: anticoagulationtherapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not be given to individuals solely to prevent such events? What should be used to prevent cardiac events in individuals?. ### Response: anticoagulationtherapy.


Instruction: What should be used in all patients with LV systolic dysfunction (EF 40%) with heartfailure or prior MI unless contraindicated?

Output: Beta-blocker therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be used in all patients with LV systolic dysfunction (EF 40%) with heartfailure or prior MI unless contraindicated?. ### Response: Beta-blocker therapy.


Instruction: How long should beta-blocker therapy be started and continued in patients with normal LV function after MI or ACS?

Output: 3 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long should beta-blocker therapy be started and continued in patients with normal LV function after MI or ACS?. ### Response: 3 years.


Instruction: What percentage of EF is associated with heart failure or prior MI?

Output: <40%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of EF is associated with heart failure or prior MI?. ### Response: <40%).


Instruction: What should be limited to carvedilol?

Output: Beta-blocker therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be limited to carvedilol?. ### Response: Beta-blocker therapy.


Instruction: What cant determinant of whether the DBP is a major risk predictor?

Output: cant determinant of whether the DBP is a major risk predictor. Therefore, in those studies that reported a J curve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What cant determinant of whether the DBP is a major risk predictor?. ### Response: cant determinant of whether the DBP is a major risk predictor. Therefore, in those studies that reported a J curve.


Instruction: What are possible explanations for diminished myocardial perfusion during diastole?

Output: an age-related increase in pulse pressure reflecting stiffer large arteries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are possible explanations for diminished myocardial perfusion during diastole?. ### Response: an age-related increase in pulse pressure reflecting stiffer large arteries.


Instruction: What type of epiphenomenon is related to a known or undetected underlying illness?

Output: cancer, HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of epiphenomenon is related to a known or undetected underlying illness?. ### Response: cancer, HF.


Instruction: What is reverse causality?

Output: the pre-existing illness explains both the low BP and the high risk of death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reverse causality?. ### Response: the pre-existing illness explains both the low BP and the high risk of death.


Instruction: How many 1991 patients participated in the CAMELOT trial?

Output: 150

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many 1991 patients participated in the CAMELOT trial?. ### Response: 150.


Instruction: How many patients had angiographically documented CAD in the CAMELOT trial in 1991?

Output: 150

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had angiographically documented CAD in the CAMELOT trial in 1991?. ### Response: 150.


Instruction: What was the mean entry BP?

Output: 129/77 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean entry BP?. ### Response: 129/77 mm Hg.


Instruction: How much did treatment with an ACE inhibi-tor or a CCB lowered BP by?

Output: 5/2 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much did treatment with an ACE inhibi-tor or a CCB lowered BP by?. ### Response: 5/2 mm Hg.


Instruction: What percentage of white adults with diabetes mellitus have coronary heart disease?

Output: ≈45%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of white adults with diabetes mellitus have coronary heart disease?. ### Response: ≈45%.


Instruction: What type of trials have not shown a J curve?

Output: Clinical Trials to Specifically Evaluate Lower  BP GoalsData from controlled trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of trials have not shown a J curve?. ### Response: Clinical Trials to Specifically Evaluate Lower  BP GoalsData from controlled trials.


Instruction: What percent of white adults with diabetes mellitus have coronary heart disease?

Output: ≈45%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percent of white adults with diabetes mellitus have coronary heart disease?. ### Response: ≈45%.


Instruction: What percentage of non-diabetic individuals have CAD?

Output: 25%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of non-diabetic individuals have CAD?. ### Response: 25%.


Instruction: The ACCORD study is relevant to the issue of what?

Output: BP targets

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The ACCORD study is relevant to the issue of what?. ### Response: BP targets.


Instruction: What did the BP study20 randomized 4733 patients to?

Output: an intensive therapy arm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the BP study20 randomized 4733 patients to?. ### Response: an intensive therapy arm.


Instruction: How many patients had had a previous cardiovascular event?

Output: 34%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had had a previous cardiovascular event?. ### Response: 34%.


Instruction: What was the SBP target?

Output: <120 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the SBP target?. ### Response: <120 mm Hg.


Instruction: What was the mean SBP in the intensive therapy group after 1 year?

Output: 119.3 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean SBP in the intensive therapy group after 1 year?. ### Response: 119.3 mm Hg.


Instruction: How was the SBP target in the standard therapy group?

Output: 133.5 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the SBP target in the standard therapy group?. ### Response: 133.5 mm Hg.


Instruction: After 1 year, what was the average SBP?

Output: 119.3 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: After 1 year, what was the average SBP?. ### Response: 119.3 mm Hg.


Instruction: How many mm Hg difference was there in the standard therapy group?

Output: 14

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mm Hg difference was there in the standard therapy group?. ### Response: 14.


Instruction: What was the mean follow-up of the study?

Output: 4.7 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean follow-up of the study?. ### Response: 4.7 years.


Instruction: How long did the study last?

Output: 4.7 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the study last?. ### Response: 4.7 years.


Instruction: Why was there no difference between the 2 groups?

Output: primary composite outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was there no difference between the 2 groups?. ### Response: primary composite outcome.


Instruction: What is another term for nonfatal stroke?

Output: death resulting from cardiovascular causes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for nonfatal stroke?. ### Response: death resulting from cardiovascular causes.


Instruction: What is a term for all-cause mortality?

Output: nonfa-tal MI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a term for all-cause mortality?. ### Response: nonfa-tal MI.


Instruction: How much lower was the risk of the primary composite end point in those randomized to the lower goal?

Output: 12%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much lower was the risk of the primary composite end point in those randomized to the lower goal?. ### Response: 12%).


Instruction: What was the risk of MI in the group randomized to the lower BP target?

Output: lower (by 13%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk of MI in the group randomized to the lower BP target?. ### Response: lower (by 13%).


Instruction: What was not statistically significant?

Output: the risk of MI was lower (by 13%) in the group randomized to the lower BP target

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not statistically significant?. ### Response: the risk of MI was lower (by 13%) in the group randomized to the lower BP target.


Instruction: In the intensive therapy group, what was the putatively significantly lower incidence of stroke?

Output: uncorrected for multiple comparisons

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the intensive therapy group, what was the putatively significantly lower incidence of stroke?. ### Response: uncorrected for multiple comparisons.


Instruction: How many strokes were there in the intensive therapy group?

Output: 98

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes were there in the intensive therapy group?. ### Response: 98.


Instruction: What was the number of strokes?

Output: 98

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the number of strokes?. ### Response: 98.


Instruction: Who concluded that an SBP 120 mm Hg in type 2 dia-betes mellitus is not justified?

Output: investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who concluded that an SBP 120 mm Hg in type 2 dia-betes mellitus is not justified?. ### Response: investigators.


Instruction: What cant determinant of whether the DBP is a major risk predictor?

Output: cant determinant of whether the DBP is a major risk predictor. Therefore, in those studies that reported a J curve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What cant determinant of whether the DBP is a major risk predictor?. ### Response: cant determinant of whether the DBP is a major risk predictor. Therefore, in those studies that reported a J curve.


Instruction: What are possible explanations for diminished myocardial perfusion during diastole?

Output: an age-related increase in pulse pressure reflecting stiffer large arteries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are possible explanations for diminished myocardial perfusion during diastole?. ### Response: an age-related increase in pulse pressure reflecting stiffer large arteries.


Instruction: What type of epiphenomenon is related to a known or undetected underlying illness?

Output: cancer, HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of epiphenomenon is related to a known or undetected underlying illness?. ### Response: cancer, HF.


Instruction: What is reverse causality?

Output: the pre-existing illness explains both the low BP and the high risk of death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reverse causality?. ### Response: the pre-existing illness explains both the low BP and the high risk of death.


Instruction: How many 1991 patients participated in the CAMELOT trial?

Output: 150

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many 1991 patients participated in the CAMELOT trial?. ### Response: 150.


Instruction: How many patients had angiographically documented CAD in the CAMELOT trial in 1991?

Output: 150

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had angiographically documented CAD in the CAMELOT trial in 1991?. ### Response: 150.


Instruction: What was the mean entry BP?

Output: 129/77 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean entry BP?. ### Response: 129/77 mm Hg.


Instruction: How much did treatment with an ACE inhibi-tor or a CCB lowered BP by?

Output: 5/2 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much did treatment with an ACE inhibi-tor or a CCB lowered BP by?. ### Response: 5/2 mm Hg.


Instruction: What percentage of white adults with diabetes mellitus have coronary heart disease?

Output: ≈45%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of white adults with diabetes mellitus have coronary heart disease?. ### Response: ≈45%.


Instruction: What type of trials have not shown a J curve?

Output: Clinical Trials to Specifically Evaluate Lower  BP GoalsData from controlled trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of trials have not shown a J curve?. ### Response: Clinical Trials to Specifically Evaluate Lower  BP GoalsData from controlled trials.


Instruction: What percent of white adults with diabetes mellitus have coronary heart disease?

Output: ≈45%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percent of white adults with diabetes mellitus have coronary heart disease?. ### Response: ≈45%.


Instruction: What percentage of non-diabetic individuals have CAD?

Output: 25%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of non-diabetic individuals have CAD?. ### Response: 25%.


Instruction: The ACCORD study is relevant to the issue of what?

Output: BP targets

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The ACCORD study is relevant to the issue of what?. ### Response: BP targets.


Instruction: What did the BP study20 randomized 4733 patients to?

Output: an intensive therapy arm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the BP study20 randomized 4733 patients to?. ### Response: an intensive therapy arm.


Instruction: How many patients had had a previous cardiovascular event?

Output: 34%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had had a previous cardiovascular event?. ### Response: 34%.


Instruction: What was the SBP target?

Output: <120 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the SBP target?. ### Response: <120 mm Hg.


Instruction: What was the mean SBP in the intensive therapy group after 1 year?

Output: 119.3 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean SBP in the intensive therapy group after 1 year?. ### Response: 119.3 mm Hg.


Instruction: How was the SBP target in the standard therapy group?

Output: 133.5 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the SBP target in the standard therapy group?. ### Response: 133.5 mm Hg.


Instruction: After 1 year, what was the average SBP?

Output: 119.3 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: After 1 year, what was the average SBP?. ### Response: 119.3 mm Hg.


Instruction: How many mm Hg difference was there in the standard therapy group?

Output: 14

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mm Hg difference was there in the standard therapy group?. ### Response: 14.


Instruction: What was the mean follow-up of the study?

Output: 4.7 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean follow-up of the study?. ### Response: 4.7 years.


Instruction: How long did the study last?

Output: 4.7 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the study last?. ### Response: 4.7 years.


Instruction: Why was there no difference between the 2 groups?

Output: primary composite outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was there no difference between the 2 groups?. ### Response: primary composite outcome.


Instruction: What is another term for nonfatal stroke?

Output: death resulting from cardiovascular causes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for nonfatal stroke?. ### Response: death resulting from cardiovascular causes.


Instruction: What is a term for all-cause mortality?

Output: nonfa-tal MI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a term for all-cause mortality?. ### Response: nonfa-tal MI.


Instruction: How much lower was the risk of the primary composite end point in those randomized to the lower goal?

Output: 12%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much lower was the risk of the primary composite end point in those randomized to the lower goal?. ### Response: 12%).


Instruction: What was the risk of MI in the group randomized to the lower BP target?

Output: lower (by 13%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk of MI in the group randomized to the lower BP target?. ### Response: lower (by 13%).


Instruction: What was not statistically significant?

Output: the risk of MI was lower (by 13%) in the group randomized to the lower BP target

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not statistically significant?. ### Response: the risk of MI was lower (by 13%) in the group randomized to the lower BP target.


Instruction: In the intensive therapy group, what was the putatively significantly lower incidence of stroke?

Output: uncorrected for multiple comparisons

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the intensive therapy group, what was the putatively significantly lower incidence of stroke?. ### Response: uncorrected for multiple comparisons.


Instruction: How many strokes were there in the intensive therapy group?

Output: 98

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes were there in the intensive therapy group?. ### Response: 98.


Instruction: What was the number of strokes?

Output: 98

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the number of strokes?. ### Response: 98.


Instruction: Who concluded that an SBP 120 mm Hg in type 2 dia-betes mellitus is not justified?

Output: investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who concluded that an SBP 120 mm Hg in type 2 dia-betes mellitus is not justified?. ### Response: investigators.


Instruction: What is the date of the update inf orma tion?

Output: March 2022

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the date of the update inf orma tion?. ### Response: March 2022.


Instruction: What has been reviewed on the evidence on blood pr essur e tar gets for people with cardiovascular disease?

Output: diagnosis, monit oring and drug tr eatment f or hyper tension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been reviewed on the evidence on blood pr essur e tar gets for people with cardiovascular disease?. ### Response: diagnosis, monit oring and drug tr eatment f or hyper tension.


Instruction: What did we r eassess on antih yper tensiv e drug tr eatment?

Output: evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did we r eassess on antih yper tensiv e drug tr eatment?. ### Response: evidence.


Instruction: What is mark ed [2022]?

Output: We have review ed the evidence on blood pr essur e tar gets for people wit h cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is mark ed [2022]?. ### Response: We have review ed the evidence on blood pr essur e tar gets for people wit h cardiovascular disease.


Instruction: For recommendations ending [2019, amended 2022], what have we not reviewed?

Output: the evidence for people wit hout car diovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For recommendations ending [2019, amended 2022], what have we not reviewed?. ### Response: the evidence for people wit hout car diovascular disease.


Instruction: What has not been reviewed for people wit hout car diovascular disease?

Output: evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has not been reviewed for people wit hout car diovascular disease?. ### Response: evidence.


Instruction: What have we made minor changes t o the w ording of the recommendations?

Output: ascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have we made minor changes t o the w ording of the recommendations?. ### Response: ascular disease.


Instruction: What is t he rationale and impact section on blood pr essur e tar gets for people wit h cardiovascular disease?

Output: W e have made minor changes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is t he rationale and impact section on blood pr essur e tar gets for people wit h cardiovascular disease?. ### Response: W e have made minor changes.


Instruction: August 2019: We have reviewed the evidence and made new recommendations on what?

Output: diagnosis, monit oring and drug tr eatment f or hyper tension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: August 2019: We have reviewed the evidence and made new recommendations on what?. ### Response: diagnosis, monit oring and drug tr eatment f or hyper tension.


Instruction: What are new r ecommendations on diagnosis, monitoring and drug tr eatment f or hyper tension and identifying who to refer for same-da y specialists?

Output: Hyper tension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are new r ecommendations on diagnosis, monitoring and drug tr eatment f or hyper tension and identifying who to refer for same-da y specialists?. ### Response: Hyper tension.


Instruction: What have we also made some changes wit hout an evidence?

Output: minor changes ha ve been made t o the wording t o bring t he language and style up t o dat e

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have we also made some changes wit hout an evidence?. ### Response: minor changes ha ve been made t o the wording t o bring t he language and style up t o dat e.


Instruction: What was mo ved to avoid repetition?

Output: the inf ormation on cuff siz e for measuring blood pr essur e

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was mo ved to avoid repetition?. ### Response: the inf ormation on cuff siz e for measuring blood pr essur e.


Instruction: What was r eplaced wit h gly cated haemoglobin?

Output: plasma glucose t esting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was r eplaced wit h gly cated haemoglobin?. ### Response: plasma glucose t esting.


Instruction: What is gly cated haemoglobin?

Output: Hb A1C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is gly cated haemoglobin?. ### Response: Hb A1C.


Instruction: Why was a not e added because of concerns about risks of salt substitut es in some groups?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was a not e added because of concerns about risks of salt substitut es in some groups?. ### Response: •.


Instruction: The inf ormation on when to refer to the hyper tension in pregnancy guideline was made clear what?

Output: NICE 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The inf ormation on when to refer to the hyper tension in pregnancy guideline was made clear what?. ### Response: NICE 2023.


Instruction: When was the hyper tension in pregnancy guideline made clearer?

Output: August  2019

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the hyper tension in pregnancy guideline made clearer?. ### Response: August  2019.


Instruction: When were the recommendations mark ed?

Output: 2004] , [2006] , [2008] , [2009]

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When were the recommendations mark ed?. ### Response: 2004] , [2006] , [2008] , [2009].


Instruction: What was the last evidence r eview in 2004?

Output: 2011]  last had an evidence r eview in t hat y ear

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the last evidence r eview in 2004?. ### Response: 2011]  last had an evidence r eview in t hat y ear.


Instruction: When was the last time an evidence r eview in t hat year?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last time an evidence r eview in t hat year?. ### Response: 2011.


Instruction: What has been made in some cases to bring the language and style up to dat e?

Output: minor changes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been made in some cases to bring the language and style up to dat e?. ### Response: minor changes.


Instruction: Hyper tension in adulthood?

Output: diagnosis and management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hyper tension in adulthood?. ### Response: diagnosis and management.


Instruction: What is hyper tension in adult s: diagnosis and management (NG136)?

Output: drug tr eatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hyper tension in adult s: diagnosis and management (NG136)?. ### Response: drug tr eatment.


Instruction: When was the last updat ed?

Output: 18 Mar ch 2022

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last updat ed?. ### Response: 18 Mar ch 2022.


Instruction: What reduces stroke after coronary artery surgery?

Output: coronary artery bypass grafting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What reduces stroke after coronary artery surgery?. ### Response: coronary artery bypass grafting.


Instruction: What does intensive man-agement of cerebral hemodynamics and atheromatous aorta reduce?

Output: cestroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does intensive man-agement of cerebral hemodynamics and atheromatous aorta reduce?. ### Response: cestroke.


Instruction: How manycardiac surgical patients were treated with epiaortic ultrasound?

Output: 6051

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How manycardiac surgical patients were treated with epiaortic ultrasound?. ### Response: 6051.


Instruction: How many cardiac surgical patients were treated with intraoperative surgical management?

Output: 6051

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many cardiac surgical patients were treated with intraoperative surgical management?. ### Response: 6051.


Instruction: What is the name of the study that investigated intraoperativeepiaortic ultrasound for preventing stroke after coronaryartery bypass surgery?

Output: Tanaka M

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated intraoperativeepiaortic ultrasound for preventing stroke after coronaryartery bypass surgery?. ### Response: Tanaka M.


Instruction: What is postoperativestroke related to in cardiac surgery?

Output: the location and extent ofatherosclerotic disease in the ascending aorta

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is postoperativestroke related to in cardiac surgery?. ### Response: the location and extent ofatherosclerotic disease in the ascending aorta.


Instruction: What is the location and extent of atherosclerotic disease in the ascending aorta related to?

Output: Postoperativestroke in cardiac surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the location and extent of atherosclerotic disease in the ascending aorta related to?. ### Response: Postoperativestroke in cardiac surgery.


Instruction: When was the J Am Coll Cardiol.38:131–5.851 published?

Output: 2001

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol.38:131–5.851 published?. ### Response: 2001.


Instruction: What is superior to both transesophageal echocardiography and direct palpation?

Output: epiaortic imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is superior to both transesophageal echocardiography and direct palpation?. ### Response: epiaortic imaging.


Instruction: What is the difference between digital palpations and epiaortic ultrasonography?

Output: risk of perioperative stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between digital palpations and epiaortic ultrasonography?. ### Response: risk of perioperative stroke.


Instruction: When was the J Cardiothorac VascAnesth published?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Cardiothorac VascAnesth published?. ### Response: 2007.


Instruction: What is the name of the study that investigated the effects of aortic atherosclerosis and neurological dysfunction in elderly coronary surgicalpatients?

Output: Anesth.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the effects of aortic atherosclerosis and neurological dysfunction in elderly coronary surgicalpatients?. ### Response: Anesth..


Instruction: What is a major impact of the modification of surgicaltechnique?

Output: strokereduction in coronary artery bypass grafting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a major impact of the modification of surgicaltechnique?. ### Response: strokereduction in coronary artery bypass grafting.


Instruction: What is the impact of echo-directed aortic cannulation on outcomes in coronary surgery?

Output: Improving outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact of echo-directed aortic cannulation on outcomes in coronary surgery?. ### Response: Improving outcomes.


Instruction: What is a factor associated withpresence of ascending aartic atherosclerosis in CABG patients?

Output: Postoperativestroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a factor associated withpresence of ascending aartic atherosclerosis in CABG patients?. ### Response: Postoperativestroke.


Instruction: How many patients underwent echo-directed aortic cannulation in 2004?

Output: 500

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients underwent echo-directed aortic cannulation in 2004?. ### Response: 500.


Instruction: What was the impact of echo-directed cannula and perioperative hemodynamic management in 500 patients?

Output: Improving outcomes incoronary surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the impact of echo-directed cannula and perioperative hemodynamic management in 500 patients?. ### Response: Improving outcomes incoronary surgery.


Instruction: When was the Ann ThoracSurg. 78:1579–85.857?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Ann ThoracSurg. 78:1579–85.857?. ### Response: 2004.


Instruction: How was the risk of stroke assessed by epiaortical ultrasono-graphic scanning?

Output: efficacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the risk of stroke assessed by epiaortical ultrasono-graphic scanning?. ### Response: efficacy.


Instruction: What year did J CardiothoracSurg publish a report on mandatory versus selective preoperative carotid screening?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did J CardiothoracSurg publish a report on mandatory versus selective preoperative carotid screening?. ### Response: 2006.


Instruction: What year was the AnnThorac Surg published?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the AnnThorac Surg published?. ### Response: 2003.


Instruction: When was the Am J Roentgenol published in 2007?

Output: 2007;188:W475–79.860

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Am J Roentgenol published in 2007?. ### Response: 2007;188:W475–79.860.


Instruction: What is a critical review of the literature on coronary artery bypass?

Output: Carotid artery disease andstroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a critical review of the literature on coronary artery bypass?. ### Response: Carotid artery disease andstroke.


Instruction: What is the Executive Committee for the Asymptomatic Carotid Atherosclerosis?

Output: Eur J Vasc Endovasc Surg. 2002;23:283–94.861

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Executive Committee for the Asymptomatic Carotid Atherosclerosis?. ### Response: Eur J Vasc Endovasc Surg. 2002;23:283–94.861.


Instruction: What is the name of the prospective feasibility trial?

Output: PROTECT II

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective feasibility trial?. ### Response: PROTECT II.


Instruction: What system was used in the PROTECT I Trial?

Output: Impella 2.5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What system was used in the PROTECT I Trial?. ### Response: Impella 2.5.


Instruction: When was the initial US experience?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the initial US experience?. ### Response: 2009.


Instruction: What is the name of the European registry that supports high-risk percutaneouscoronary intervention?

Output: Europella

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the European registry that supports high-risk percutaneouscoronary intervention?. ### Response: Europella.


Instruction: What is PROTECT II?

Output: A Prospective, Multicenter, Randomized Controlled Trialof the IMPELLA RECOVER LP 2.5 System Versus Intra AorticBalloon Pump in Patients Undergoing Non Emergent High Risk PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PROTECT II?. ### Response: A Prospective, Multicenter, Randomized Controlled Trialof the IMPELLA RECOVER LP 2.5 System Versus Intra AorticBalloon Pump in Patients Undergoing Non Emergent High Risk PCI.


Instruction: In what year was the Europella registry published?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was the Europella registry published?. ### Response: 2009.


Instruction: What is the name of the non-emergency high risk PCI)trial?

Output: PROTECT II

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the non-emergency high risk PCI)trial?. ### Response: PROTECT II.


Instruction: When was the trial available?

Output: August 16, 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the trial available?. ### Response: August 16, 2011.


Instruction: What is a percutaneous ventricular assistdevice called?

Output: TandemHeart

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a percutaneous ventricular assistdevice called?. ### Response: TandemHeart.


Instruction: What is the name of the percutaneous ventricular assist device?

Output: TandemHeart

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the percutaneous ventricular assist device?. ### Response: TandemHeart.


Instruction: What does the tandem heart percutane-ous left ventricular aid device do?

Output: invasive hemodynamics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the tandem heart percutane-ous left ventricular aid device do?. ### Response: invasive hemodynamics.


Instruction: Who is the author of the paper that discusses the impact of a tandem heart assist device on invasive hemodynamics?

Output: Singh IM, Holmes DR Jr, Rihal CS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of the paper that discusses the impact of a tandem heart assist device on invasive hemodynamics?. ### Response: Singh IM, Holmes DR Jr, Rihal CS.


Instruction: What is the name of the safe and effective ventricular assist device?

Output: Impella Recover 2.5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the safe and effective ventricular assist device?. ### Response: Impella Recover 2.5.


Instruction: When was the catheter cardiovasc interv. 2011 published?

Output: January 13, 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the catheter cardiovasc interv. 2011 published?. ### Response: January 13, 2011.


Instruction: What is the name of the percutaneous left ventricular assistdevice?

Output: TandemHeart

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the percutaneous left ventricular assistdevice?. ### Response: TandemHeart.


Instruction: When was the online before print version of this study published?

Output: January 13, 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the online before print version of this study published?. ### Response: January 13, 2011.


Instruction: What was the name given to the device used during high-risk PCI in patients declined for CABG?

Output: TandemHeart

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name given to the device used during high-risk PCI in patients declined for CABG?. ### Response: TandemHeart.


Instruction: What is TandemHeart?

Output: percutaneous ventricular assist device

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is TandemHeart?. ### Response: percutaneous ventricular assist device.


Instruction: When was the CatheterCardiovasc Interv. 65:346-52.556?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the CatheterCardiovasc Interv. 65:346-52.556?. ### Response: 2005.


Instruction: What is the single-center experience of arterial pre-closure technique?

Output: Clinical application

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the single-center experience of arterial pre-closure technique?. ### Response: Clinical application.


Instruction: What is Green SM, Krauss B. Procedural sedation terminology: moving beyond what?

Output: conscious sedation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Green SM, Krauss B. Procedural sedation terminology: moving beyond what?. ### Response: conscious sedation.


Instruction: Who is the American Society of Anesthesiologists Task Force on Sedation and Analgesia by Non-Anesthesiologist?

Output: Practice guidelines for sedation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the American Society of Anesthesiologists Task Force on Sedation and Analgesia by Non-Anesthesiologist?. ### Response: Practice guidelines for sedation.


Instruction: What is the name of the Comprehensive Accreditation Manual: CAMH for Hospitals?

Output: Com-prehensive Accreditation Manual

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Comprehensive Accreditation Manual: CAMH for Hospitals?. ### Response: Com-prehensive Accreditation Manual.


Instruction: Where is Oak-brookTerrace, Il?

Output: Joint Commission Resources

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Oak-brookTerrace, Il?. ### Response: Joint Commission Resources.


Instruction: What is a randomized comparison of?

Output: IMPELLA RECOVER LP 2.5 System Versus Intra AorticBalloon Pump in Patients Undergoing Non Emergent High Risk PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a randomized comparison of?. ### Response: IMPELLA RECOVER LP 2.5 System Versus Intra AorticBalloon Pump in Patients Undergoing Non Emergent High Risk PCI.


Instruction: What is the name of the journal that was downloaded from http://ahajournals.org on April 26, 2023?

Output: ahajournals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that was downloaded from http://ahajournals.org on April 26, 2023?. ### Response: ahajournals.


Instruction: What is the name of the convertase subtilisin/kexin type 9 inhibitor?

Output: PCSK9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the convertase subtilisin/kexin type 9 inhibitor?. ### Response: PCSK9.


Instruction: What is the name of the 2011 ACCF/AHA expert consensus document on hypertension in the elderly?

Output: S9.2.2-16

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2011 ACCF/AHA expert consensus document on hypertension in the elderly?. ### Response: S9.2.2-16.


Instruction: What was developed in collaboration with the American Academy of Neurology, American Geriatrics Society and American Society for Aging?

Output: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was developed in collaboration with the American Academy of Neurology, American Geriatrics Society and American Society for Aging?. ### Response: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents.


Instruction: What is the American Academy of Neurology?

Output: JAMA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the American Academy of Neurology?. ### Response: JAMA.


Instruction: What are the American Society for Preventive Cardiology, American Society of Nephrology, and European Society of Hypertension?

Output: Association of Black Cardiologists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the American Society for Preventive Cardiology, American Society of Nephrology, and European Society of Hypertension?. ### Response: Association of Black Cardiologists.


Instruction: When was Circulation. 2011;123:2434–506.

Output: S9.2.2-17

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Circulation. 2011;123:2434–506.. ### Response: S9.2.2-17.


Instruction: What is prevention of heart failure?

Output: antihypertensive drug treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is prevention of heart failure?. ### Response: antihypertensive drug treatment.


Instruction: What does antihypertensive drug treatment prevent?

Output: heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does antihypertensive drug treatment prevent?. ### Response: heart failure.


Instruction: What is the name of the group that studies the prevention of heart failure in older people?

Output: SHEP Cooperative Research Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that studies the prevention of heart failure in older people?. ### Response: SHEP Cooperative Research Group.


Instruction: When was the JAMA published?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the JAMA published?. ### Response: 2013.


Instruction: How old were the patients treated for hypertension?

Output: 80 years of age or older

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old were the patients treated for hypertension?. ### Response: 80 years of age or older.


Instruction: What year did N Engl J Med publish 358:1887-98?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did N Engl J Med publish 358:1887-98?. ### Response: 2008.


Instruction: What is the name of the antihypertensive and lipid-lowering treatment to prevent heart attack trial?

Output: ALLHAT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the antihypertensive and lipid-lowering treatment to prevent heart attack trial?. ### Response: ALLHAT.


Instruction: When was the ALHAT trial conducted?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the ALHAT trial conducted?. ### Response: 2011.


Instruction: What is the effect of inhibition of phosphodies-terase-5 on exercise capacity and clinical status?

Output: heart failure with preserved ejection fraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of inhibition of phosphodies-terase-5 on exercise capacity and clinical status?. ### Response: heart failure with preserved ejection fraction.


Instruction: What is a potential benefit of inhibition?

Output: exercise capacity and clinical status

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a potential benefit of inhibition?. ### Response: exercise capacity and clinical status.


Instruction: How does heart failure compare to antihy-pertensive?

Output: pre-served and reduced left ventricular ejection fraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does heart failure compare to antihy-pertensive?. ### Response: pre-served and reduced left ventricular ejection fraction.


Instruction: What is the effect of phosphodies-terase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction?

Output: a randomized clinical trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of phosphodies-terase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction?. ### Response: a randomized clinical trial.


Instruction: What journal published a randomized clinical trial in 2013?

Output: JAMA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What journal published a randomized clinical trial in 2013?. ### Response: JAMA.


Instruction: How does dietary protein restriction and blood pressure control affect the progression of chronic renal disease?

Output: The effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does dietary protein restriction and blood pressure control affect the progression of chronic renal disease?. ### Response: The effects.


Instruction: What is the effect of blood-pressure control on the progression of chronic renal disease?

Output: dietary protein restriction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of blood-pressure control on the progression of chronic renal disease?. ### Response: dietary protein restriction.


Instruction: What was the name of the multicentre, randomised controlled trial of blood pressure control for renoprotection in non-diabetic chronic renal disease?

Output: REIN-2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the multicentre, randomised controlled trial of blood pressure control for renoprotection in non-diabetic chronic renal disease?. ### Response: REIN-2.


Instruction: What is chronic renal dis-ease?

Output: REIN-2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is chronic renal dis-ease?. ### Response: REIN-2.


Instruction: What is the name of the multicentre, randomised controlled trial?

Output: Blood-pressure control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multicentre, randomised controlled trial?. ### Response: Blood-pressure control.


Instruction: When did the AASK trial begin?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the AASK trial begin?. ### Response: 2002.


Instruction: What is a blood pressure target in chronic kidney disease and proteinuria as an effect modifier?

Output: Systematic review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a blood pressure target in chronic kidney disease and proteinuria as an effect modifier?. ### Response: Systematic review.


Instruction: When was the Ann Intern Med published?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Ann Intern Med published?. ### Response: 2011.


Instruction: What is the effect of intensive blood pres-sure lowering on the progression of chronic renal disease?

Output: a sys-tematic review and meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of intensive blood pres-sure lowering on the progression of chronic renal disease?. ### Response: a sys-tematic review and meta-analysis.


Instruction: What is the effect of intensive blood pressure lowering on the progression of chronic kidney disease?

Output: Effects of intensive blood pres-sure lowering on the progression of chronic kidney disease: a sys-tematic review and meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of intensive blood pressure lowering on the progression of chronic kidney disease?. ### Response: Effects of intensive blood pres-sure lowering on the progression of chronic kidney disease: a sys-tematic review and meta-analysis.


Instruction: When did CMAJ publish a sys-tematic review and meta-analysis?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did CMAJ publish a sys-tematic review and meta-analysis?. ### Response: 2013.


Instruction: What did Jafar TH, Stark PC, Schmid CH, et al. study?

Output: Progression of chronic kid-ney disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Jafar TH, Stark PC, Schmid CH, et al. study?. ### Response: Progression of chronic kid-ney disease.


Instruction: What enzyme inhibits angiotensin-converting enzymes?

Output: phosphodies-terase-5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What enzyme inhibits angiotensin-converting enzymes?. ### Response: phosphodies-terase-5.


Instruction: What is a patient-level meta-analysis?

Output: Progression of chronic kid-ney disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a patient-level meta-analysis?. ### Response: Progression of chronic kid-ney disease.


Instruction: Ann Intern Med 2003;139:244–52.

Output: Progression of chronic kid-ney disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Ann Intern Med 2003;139:244–52.. ### Response: Progression of chronic kid-ney disease.


Instruction: What should be administered as soon as possible after CABG in those without contraindications to reduce the risk of AF201,202 and improve outcomes in those patients?

Output: β-Blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be administered as soon as possible after CABG in those without contraindications to reduce the risk of AF201,202 and improve outcomes in those patients?. ### Response: β-Blockers.


Instruction: What has not been systematically explored?

Output: their effect on BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has not been systematically explored?. ### Response: their effect on BP.


Instruction: What did Sjoland et al find no benefit asso-ciated with a 2-year treatment with metoprolol after 2 years?

Output: reduce the inci-dence of repeat revascularization, unstable angina, nonfatal MI, or death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Sjoland et al find no benefit asso-ciated with a 2-year treatment with metoprolol after 2 years?. ### Response: reduce the inci-dence of repeat revascularization, unstable angina, nonfatal MI, or death.


Instruction: Metoprolol did not reduce the inci-dence of repeat revascularization, unstable angina, nonfatal MI, or death compared to what other drug?

Output: placebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Metoprolol did not reduce the inci-dence of repeat revascularization, unstable angina, nonfatal MI, or death compared to what other drug?. ### Response: placebo.


Instruction: What should also be considered for CABG patients after surgery?

Output: ACE inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should also be considered for CABG patients after surgery?. ### Response: ACE inhibitors.


Instruction: What is the BP-lowering effect of ACE inhibitors dependent on a patient's volume state?

Output: the basis for their frequent administration together with a diuretic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the BP-lowering effect of ACE inhibitors dependent on a patient's volume state?. ### Response: the basis for their frequent administration together with a diuretic.


Instruction: What can be associated with a syndrome of functional renal insuf-ficiency?

Output: ACE inhibitor use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be associated with a syndrome of functional renal insuf-ficiency?. ### Response: ACE inhibitor use.


Instruction: What can be associated with a syndrome of functional renal insuf-ficiency or hyperkalemia?

Output: ACE inhibitor use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be associated with a syndrome of functional renal insuf-ficiency or hyperkalemia?. ### Response: ACE inhibitor use.


Instruction: What develops shortly after the initiation of ACE inhibitor therapy but can be observed after months or years of therapy?

Output: acute kidney injury

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What develops shortly after the initiation of ACE inhibitor therapy but can be observed after months or years of therapy?. ### Response: acute kidney injury.


Instruction: How many randomized, controlled trials have studied the use of an ARB?

Output: 2253

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many randomized, controlled trials have studied the use of an ARB?. ### Response: 2253.


Instruction: What may be considered as an alternative in an ACE inhibitor-intolerant patient?

Output: An ARB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered as an alternative in an ACE inhibitor-intolerant patient?. ### Response: An ARB.


Instruction: How many randomized, controlled trials have studied the use of ACE inhibitors after CABG?

Output: Two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many randomized, controlled trials have studied the use of ACE inhibitors after CABG?. ### Response: Two.


Instruction: In a 149-patient trial, investigators noted a reduction in the composite outcome of angina, death, MI, repeat revascularization, stroke or transient ischemic attacks in patients who received quinapril after surgery?

Output: 232

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In a 149-patient trial, investigators noted a reduction in the composite outcome of angina, death, MI, repeat revascularization, stroke or transient ischemic attacks in patients who received quinapril after surgery?. ### Response: 232.


Instruction: What was the difference between quinapril and pla-cebo in ischemic attacks?

Output: 3.5% versus 15%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the difference between quinapril and pla-cebo in ischemic attacks?. ### Response: 3.5% versus 15%,.


Instruction: What did IMAGINE stand for?

Output: Ischemia Management With Accupril Post-Bypass Graft via Inhibition of the Converting Enzyme

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did IMAGINE stand for?. ### Response: Ischemia Management With Accupril Post-Bypass Graft via Inhibition of the Converting Enzyme.


Instruction: How many patients were in the mul-ticenter Ischemia Management With Accupril Post-Bypass Graft via Inhibition of the Converting Enzyme trial?

Output: 2253

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were in the mul-ticenter Ischemia Management With Accupril Post-Bypass Graft via Inhibition of the Converting Enzyme trial?. ### Response: 2253.


Instruction: How many stable CABG patients were in the IMAGINE trial?

Output: 2253

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many stable CABG patients were in the IMAGINE trial?. ### Response: 2253.


Instruction: What type of indications were excluded from randomization?

Output: if they already had indications for ACE inhibitor therapy such as LV dysfunction, insulin-dependent diabetes mellitus, or renal dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of indications were excluded from randomization?. ### Response: if they already had indications for ACE inhibitor therapy such as LV dysfunction, insulin-dependent diabetes mellitus, or renal dysfunction.


Instruction: How much did Quinapril (40 mg daily) have compared to placebo?

Output: no benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much did Quinapril (40 mg daily) have compared to placebo?. ### Response: no benefit.


Instruction: How much benefit did the 40 mg daily placebo have?

Output: no benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much benefit did the 40 mg daily placebo have?. ### Response: no benefit.


Instruction: What was the incidence of the primary composite end point among quinapril patients?

Output: 13.7%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the incidence of the primary composite end point among quinapril patients?. ### Response: 13.7%.


Instruction: How long did the median follow-up of quinapril patients last?

Output: 2.95 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the median follow-up of quinapril patients last?. ### Response: 2.95 years.


Instruction: How much did the incidence of the primary composite end point increase in the placebo group?

Output: significantly

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much did the incidence of the primary composite end point increase in the placebo group?. ### Response: significantly.


Instruction: What is the name of the Randomised Study of Ibopamine on Mortality and Efficacy (PRIME II)investigators?

Output: PROMISE StudyResearch Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Randomised Study of Ibopamine on Mortality and Efficacy (PRIME II)investigators?. ### Response: PROMISE StudyResearch Group.


Instruction: What was the name given to the randomised study of effect of ibuprofen on survival inpatients with advanced severe heart failure?

Output: PRIME II

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name given to the randomised study of effect of ibuprofen on survival inpatients with advanced severe heart failure?. ### Response: PRIME II.


Instruction: When was the Lancet 349:971–7.285 published?

Output: 1997

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Lancet 349:971–7.285 published?. ### Response: 1997.


Instruction: What is the name of the PICO trial?

Output: Pimobendan in Congestive Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the PICO trial?. ### Response: Pimobendan in Congestive Heart Failure.


Instruction: What is PICO?

Output: Pimobendan in Congestive Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PICO?. ### Response: Pimobendan in Congestive Heart Failure.


Instruction: How does milrinone affect mortality in severe chronicheart failure?

Output: Effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does milrinone affect mortality in severe chronicheart failure?. ### Response: Effect.


Instruction: What was the N Engl J Med 1991?

Output: 325:1468 –75.287

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the N Engl J Med 1991?. ### Response: 325:1468 –75.287.


Instruction: What did Metra M, Eichhorn E, Abraham WT, et al. Effects of low-dose oralenoximone administration on mortality, morbidity, and exercise capacity in patients with advanced heart failure?

Output: randomized, double-blind,placebo-controlled, parallel group ESSENTIAL trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Metra M, Eichhorn E, Abraham WT, et al. Effects of low-dose oralenoximone administration on mortality, morbidity, and exercise capacity in patients with advanced heart failure?. ### Response: randomized, double-blind,placebo-controlled, parallel group ESSENTIAL trials.


Instruction: What is the name of the multicenter trial in which a low-dosedobutamine infusion is used in severe heart failure?

Output: DICE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multicenter trial in which a low-dosedobutamine infusion is used in severe heart failure?. ### Response: DICE.


Instruction: What is Pagani FD, Miller LW, Russell SD, et al. using?

Output: Extended mechanical circu-latory support with a continuous- ﬂow rotary left ventricular assistdevice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Pagani FD, Miller LW, Russell SD, et al. using?. ### Response: Extended mechanical circu-latory support with a continuous- ﬂow rotary left ventricular assistdevice.


Instruction: What is rotary left ventricular assistdevice?

Output: Extended mechanical circu-latory support

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is rotary left ventricular assistdevice?. ### Response: Extended mechanical circu-latory support.


Instruction: What is mechanical circulatorysupport as a bridge to transplant candidacy?

Output: rotary left ventricular assistdevice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is mechanical circulatorysupport as a bridge to transplant candidacy?. ### Response: rotary left ventricular assistdevice.


Instruction: What is mechanical circulatorysupport a bridge to?

Output: transplant candidacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is mechanical circulatorysupport a bridge to?. ### Response: transplant candidacy.


Instruction: What is pulsatile left ventricular assistdevice support?

Output: a bridge to decision

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is pulsatile left ventricular assistdevice support?. ### Response: a bridge to decision.


Instruction: What is pulmonary hypertension?

Output: end-stage heartfailure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is pulmonary hypertension?. ### Response: end-stage heartfailure.


Instruction: What is the name of the device used in patients awaiting heart transplantation?

Output: leftventricular assist device

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the device used in patients awaiting heart transplantation?. ### Response: leftventricular assist device.


Instruction: When was the N Engl J Med 357:885-96.294?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the N Engl J Med 357:885-96.294?. ### Response: 2007.


Instruction: What is a continuous flowventricular assist device used for?

Output: advanced heart-failure patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a continuous flowventricular assist device used for?. ### Response: advanced heart-failure patients.


Instruction: What is the name of the prospective study using the INTERMACS device?

Output: PROMISE StudyResearch Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective study using the INTERMACS device?. ### Response: PROMISE StudyResearch Group.


Instruction: What is Interagency Registry for MechanicallyAssisted Circulatory Support?

Output: INTERMACS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Interagency Registry for MechanicallyAssisted Circulatory Support?. ### Response: INTERMACS.


Instruction: What does INTERMACS stand for?

Output: Interagency Registry for MechanicallyAssisted Circulatory Support

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does INTERMACS stand for?. ### Response: Interagency Registry for MechanicallyAssisted Circulatory Support.


Instruction: When did Grady KL, Meyer PM, Dressler D, et al. study?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Grady KL, Meyer PM, Dressler D, et al. study?. ### Response: 2011.


Instruction: What is ventricular assist deviceimplantation?

Output: Extended mechanical circu-latory support

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ventricular assist deviceimplantation?. ### Response: Extended mechanical circu-latory support.


Instruction: When did Yancy et al. publish their 2013 ACCF/AHA Heart Failure Guidelines?

Output: October 15, 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Yancy et al. publish their 2013 ACCF/AHA Heart Failure Guidelines?. ### Response: October 15, 2013.


Instruction: What is an angiotensin-converting enzyme inhibitor?

Output: a calcium antagonist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an angiotensin-converting enzyme inhibitor?. ### Response: a calcium antagonist.


Instruction: What is a diuretic in patients with hypertension not controlled by monotherapy?

Output: angiotensin-converting enzyme inhibitor, a calcium antagonist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a diuretic in patients with hypertension not controlled by monotherapy?. ### Response: angiotensin-converting enzyme inhibitor, a calcium antagonist.


Instruction: What is the effect of antagonists on blood pressure in resistant hypertension?

Output: hypertensive effects of an angiotensin-converting enzyme inhibitor, a calcium antagonist and a diuretic in patients with hypertension not controlled by angiotensin receptor blocker monotherapy.  J Hypertens. 2005;23:883–9. S11.1-12. Liu G, Zheng XX, Xu YL, et al. Effect of aldosterone antagonists on blood pressure in patients with resistant hypertension: a meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of antagonists on blood pressure in resistant hypertension?. ### Response: hypertensive effects of an angiotensin-converting enzyme inhibitor, a calcium antagonist and a diuretic in patients with hypertension not controlled by angiotensin receptor blocker monotherapy.  J Hypertens. 2005;23:883–9. S11.1-12. Liu G, Zheng XX, Xu YL, et al. Effect of aldosterone antagonists on blood pressure in patients with resistant hypertension: a meta-analysis.


Instruction: What is PATHWAY-2?

Output: a randomised, double-blind, crossover trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PATHWAY-2?. ### Response: a randomised, double-blind, crossover trial.


Instruction: How did Williams B, MacDonald TM, Morant S, et al. determine the optimal treatment for drug-resistant hypertension: a randomised, double-blind crossover trial?

Output: Spironolactone versus placebo, bisoprolol, and doxazosin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Williams B, MacDonald TM, Morant S, et al. determine the optimal treatment for drug-resistant hypertension: a randomised, double-blind crossover trial?. ### Response: Spironolactone versus placebo, bisoprolol, and doxazosin.


Instruction: What is the name of the randomised, double-blind, crossover trial?

Output: PATHWAY-2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised, double-blind, crossover trial?. ### Response: PATHWAY-2.


Instruction: How many patients were treated with doxazosin and spironolactone in 2015?

Output: 2059–68

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with doxazosin and spironolactone in 2015?. ### Response: 2059–68.


Instruction: What are the effects of aldosterone antagonists in resistant hypertension?

Output: blood pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the effects of aldosterone antagonists in resistant hypertension?. ### Response: blood pressure.


Instruction: What is the effect of aldosterone antagonists in resistant hypertension?

Output: blood pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of aldosterone antagonists in resistant hypertension?. ### Response: blood pressure.


Instruction: What is ramipril vs amlo-dipine on in hypertensive nephrosclerosis?

Output: renal outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ramipril vs amlo-dipine on in hypertensive nephrosclerosis?. ### Response: renal outcomes.


Instruction: What is a ran-domized controlled trial of?

Output: Effect of ramipril vs amlo-dipine on renal outcomes in hypertensive nephrosclerosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a ran-domized controlled trial of?. ### Response: Effect of ramipril vs amlo-dipine on renal outcomes in hypertensive nephrosclerosis.


Instruction: What is the impact of initial blood pressure on antihypertensive response in patients with acute hypertension?

Output: Impact

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact of initial blood pressure on antihypertensive response in patients with acute hypertension?. ### Response: Impact.


Instruction: What is levidipine used for in acute heart failure?

Output: Blood Pressure Control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is levidipine used for in acute heart failure?. ### Response: Blood Pressure Control.


Instruction: What is the name of the pilot study?

Output: PATHWAY-2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the pilot study?. ### Response: PATHWAY-2.


Instruction: How many people were enrolled in the PRONTO study in 2014?

Output: 436

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were enrolled in the PRONTO study in 2014?. ### Response: 436.


Instruction: Who was a participant in the A Study of Blood Pressure Control in Acute Heart Failure?

Output: Peacock WF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was a participant in the A Study of Blood Pressure Control in Acute Heart Failure?. ### Response: Peacock WF.


Instruction: What does Viniou NA do?

Output: Cardiovascular hypertensive emergencies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Viniou NA do?. ### Response: Cardiovascular hypertensive emergencies.