Instruction: How many cardiovascular patients were examined in aretrospective analysis?

Output: 15 592

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many cardiovascular patients were examined in aretrospective analysis?. ### Response: 15 592.


Instruction: Therisk of septicemia/bacteremia increased incrementally with each unit of blood transfused with what?

Output: deepsternal wound infections

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Therisk of septicemia/bacteremia increased incrementally with each unit of blood transfused with what?. ### Response: deepsternal wound infections.


Instruction: What are present in packed red blood cells induce the immunomodu-latory effects associated with blood transfusions?

Output: leukocytes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are present in packed red blood cells induce the immunomodu-latory effects associated with blood transfusions?. ### Response: leukocytes.


Instruction: Allo-genic transfusion of blood containing leukocytes induce higher concentrations of what?

Output: proinflammatory mediators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Allo-genic transfusion of blood containing leukocytes induce higher concentrations of what?. ### Response: proinflammatory mediators.


Instruction: What are interleukins 6 and 10?

Output: proinflammatory mediators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are interleukins 6 and 10?. ### Response: proinflammatory mediators.


Instruction: What have RCTs shown about patients receiving leukocyte-filtered blood?

Output: lower rates of perioperativeinfection and in-hospital death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have RCTs shown about patients receiving leukocyte-filtered blood?. ### Response: lower rates of perioperativeinfection and in-hospital death.


Instruction: What are the rates of perioperativeinfection and in-hospital death?

Output: lower

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the rates of perioperativeinfection and in-hospital death?. ### Response: lower.


Instruction: What is the patient mortality rate at the time of donation?

Output: 7.8%;

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the patient mortality rate at the time of donation?. ### Response: 7.8%;.


Instruction: How much is the trans-fused/filtered at time of transfusion?

Output: 3.3%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much is the trans-fused/filtered at time of transfusion?. ### Response: 3.3%.


Instruction: What can be accomplished by the blood bank at thetime of donation or at the bedside?

Output: Leukodepletion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be accomplished by the blood bank at thetime of donation or at the bedside?. ### Response: Leukodepletion.


Instruction: Where can one achieve leukodepletion?

Output: by the blood bank

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can one achieve leukodepletion?. ### Response: by the blood bank.


Instruction: How much do preoperative antibiotics reduce the risk of postoperative infection?

Output: 5-fold

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much do preoperative antibiotics reduce the risk of postoperative infection?. ### Response: 5-fold.


Instruction: How long does it take to administer antibiotic prophylaxis as a single dose rather than a multiple-dosing regimen?

Output: 24 to 48 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take to administer antibiotic prophylaxis as a single dose rather than a multiple-dosing regimen?. ### Response: 24 to 48 hours.


Instruction: Why is it important to administer single-dose antibiotics instead of multiple-doses?

Output: reduces the duration of prophylaxis, itscost, and the likelihood of antimicrobial resistance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is it important to administer single-dose antibiotics instead of multiple-doses?. ### Response: reduces the duration of prophylaxis, itscost, and the likelihood of antimicrobial resistance.


Instruction: What reduces the duration of prophylaxis, itscost, and the likelihood of antimicrobial resistance?

Output: single-doseantibiotic prophylaxis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What reduces the duration of prophylaxis, itscost, and the likelihood of antimicrobial resistance?. ### Response: single-doseantibiotic prophylaxis.


Instruction: Staphylococcus coagulase-negative epidermidis accounts for what percentage of surgical site infections?

Output: 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Staphylococcus coagulase-negative epidermidis accounts for what percentage of surgical site infections?. ### Response: 50%.


Instruction: Corynebacterium and enteric gram-negativebacilli are two other organisms that are often involved in what?

Output: surgical site infections

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Corynebacterium and enteric gram-negativebacilli are two other organisms that are often involved in what?. ### Response: surgical site infections.


Instruction: What should be initiated 30 to 60 minutes before surgery?

Output: Antibiotic prophylaxis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be initiated 30 to 60 minutes before surgery?. ### Response: Antibiotic prophylaxis.


Instruction: Vancomycin should be started 2 hours before surgery and infused slowly to avoid the release of what?

Output: histamine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Vancomycin should be started 2 hours before surgery and infused slowly to avoid the release of what?. ### Response: histamine.


Instruction: In patients without methicillin-resistant S. aureus colonization, a cepha-losporin (cefazolin, 1 g given intravenously every 4 hours) should be given every 3 weeks.

Output: 903,969,970

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients without methicillin-resistant S. aureus colonization, a cepha-losporin (cefazolin, 1 g given intravenously every 4 hours) should be given every 3 weeks.. ### Response: 903,969,970.


Instruction: What is the agent of choice for standard CABG?

Output: cepha-losporin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the agent of choice for standard CABG?. ### Response: cepha-losporin.


Instruction: What is performed if the operation lasts /H110223 hours?

Output: Antibiotic redosing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is performed if the operation lasts /H110223 hours?. ### Response: Antibiotic redosing.


Instruction: Who is reserved for the patient who is allergic to cephalosporins?

Output: Vancomycinis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is reserved for the patient who is allergic to cephalosporins?. ### Response: Vancomycinis.


Instruction: Who is allergic to cephalosporins or has known or presumed methicillin-resistant S. aureuscolonization?

Output: patient

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is allergic to cephalosporins or has known or presumed methicillin-resistant S. aureuscolonization?. ### Response: patient.


Instruction: The incidence of deep sternal wound infection has de-creased over the past 15 years despite an increased risk profile?

Output: patients undergoing cardiac surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The incidence of deep sternal wound infection has de-creased over the past 15 years despite an increased risk profile?. ### Response: patients undergoing cardiac surgery.


Instruction: What is the 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction?

Output: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction?. ### Response: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.


Instruction: What is a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines?

Output: 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines?. ### Response: 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction.


Instruction: What is the difference between culprit vessel percutaneous coronary intervention and multivessel and staged percutaneous coro-nary intervention for ST-segment elevation myocardial infarction patients?

Output: Complete revascularisation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between culprit vessel percutaneous coronary intervention and multivessel and staged percutaneous coro-nary intervention for ST-segment elevation myocardial infarction patients?. ### Response: Complete revascularisation.


Instruction: What year did JACC Cardiovasc Interv. 2010:3:22–31?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did JACC Cardiovasc Interv. 2010:3:22–31?. ### Response: 2013.


Instruction: What type of intervention is used during acute ST-segment elevation myocardial infarction?

Output: Non-culprit coronary artery percu-taneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of intervention is used during acute ST-segment elevation myocardial infarction?. ### Response: Non-culprit coronary artery percu-taneous coronary intervention.


Instruction: What is the APEX-AMI trial?

Output: Non-culprit coronary artery percu-taneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the APEX-AMI trial?. ### Response: Non-culprit coronary artery percu-taneous coronary intervention.


Instruction: When was the Eur Heart J.31:1701-7?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Eur Heart J.31:1701-7?. ### Response: 2010.


Instruction: What type of intervention is used in ST-segment elevation myocardial infarction?

Output: Complete revascularisation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of intervention is used in ST-segment elevation myocardial infarction?. ### Response: Complete revascularisation.


Instruction: When was the J Am Coll Cardiol 58:692-703 published?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol 58:692-703 published?. ### Response: 2011.


Instruction: What is the primary percutaneous coronary intervention?

Output: Multivessel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary percutaneous coronary intervention?. ### Response: Multivessel.


Instruction: What type of intervention is used for ST-segment elevation myocardial infarction?

Output: Complete revascularisation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of intervention is used for ST-segment elevation myocardial infarction?. ### Response: Complete revascularisation.


Instruction: What year did the Am J Cardiol.104:507–13?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did the Am J Cardiol.104:507–13?. ### Response: 2009.


Instruction: How many patients were treated with multivessel percutaneous coronary intervention?

Output: 15

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with multivessel percutaneous coronary intervention?. ### Response: 15.


Instruction: What type of infarction is the most common?

Output: acute myocardial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of infarction is the most common?. ### Response: acute myocardial.


Instruction: What is the name of the registry used to study the impact of multivessel coronary artery disease and noninfarct-related artery revascularization on outcome of patients with ST-elevation myocardial infartion transferred for pri-mary percutaneous coronary intervention?

Output: EUROTRANSFER Registry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the registry used to study the impact of multivessel coronary artery disease and noninfarct-related artery revascularization on outcome of patients with ST-elevation myocardial infartion transferred for pri-mary percutaneous coronary intervention?. ### Response: EUROTRANSFER Registry.


Instruction: What is DANAMI 3-PRIMULTI?

Output: an open-label, randomised controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is DANAMI 3-PRIMULTI?. ### Response: an open-label, randomised controlled trial.


Instruction: What is the name of the study that compares complete revascularisation versus treatment of the culprit lesion only in patients with ST-segment elevation myocardial infarction and multivessel disease?

Output: DANAMI 3-PRIMULTI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that compares complete revascularisation versus treatment of the culprit lesion only in patients with ST-segment elevation myocardial infarction and multivessel disease?. ### Response: DANAMI 3-PRIMULTI.


Instruction: What is the name of the randomised controlled trial?

Output: DANAMI 3-PRIMULTI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised controlled trial?. ### Response: DANAMI 3-PRIMULTI.


Instruction: When was the trial downloaded?

Output: May 3, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the trial downloaded?. ### Response: May 3, 2023.


Instruction: S1.4-1. Baigent C, Blackwell L, Emberson J, et al. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials.

Output: Baigent C, Blackwell L, Emberson J, et al. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials. Lancet. 2010;376:1670–81

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: S1.4-1. Baigent C, Blackwell L, Emberson J, et al. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials.. ### Response: Baigent C, Blackwell L, Emberson J, et al. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials. Lancet. 2010;376:1670–81.


Instruction: S1.4-2. Chou R, Dana T, Blazina I, and others. Statin use for the prevention of what disease?

Output: car -diovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: S1.4-2. Chou R, Dana T, Blazina I, and others. Statin use for the prevention of what disease?. ### Response: car -diovascular disease.


Instruction: What is the purpose of statins for the prevention of car -diovascular disease in adults?

Output: primary prevention of cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of statins for the prevention of car -diovascular disease in adults?. ### Response: primary prevention of cardiovascular disease.


Instruction: Where is the US Agency for Healthcare Research and Quality located?

Output: Rockville, MD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the US Agency for Healthcare Research and Quality located?. ### Response: Rockville, MD.


Instruction: Who is the author of the systematic review for the US Preventive Services Task Force?

Output: Chou

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of the systematic review for the US Preventive Services Task Force?. ### Response: Chou.


Instruction: What are statins for the primary prevention of?

Output: cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are statins for the primary prevention of?. ### Response: cardiovascular disease.


Instruction: What is the 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atheroscle-rotic cardiovascular risk in adults?

Output: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atheroscle-rotic cardiovascular risk in adults?. ### Response: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.


Instruction: What is atheroscle-rotic cardiovascular risk in adults?

Output: reduce

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is atheroscle-rotic cardiovascular risk in adults?. ### Response: reduce.


Instruction: What is class of recommendation and level of evidence S1.5-1?

Output: S1–45.1.5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is class of recommendation and level of evidence S1.5-1?. ### Response: S1–45.1.5.


Instruction: What did the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines report on?

Output: Further evolution of the ACC/AHA clinical practice guideline recommendation classification system

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines report on?. ### Response: Further evolution of the ACC/AHA clinical practice guideline recommendation classification system.


Instruction: What was the name of the group that developed the ACC/AHA clinical practice guideline classification system?

Output: American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the group that developed the ACC/AHA clinical practice guideline classification system?. ### Response: American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.


Instruction: Cholesterol, LDL-C, and ASCVD S2.1.2-1?

Output: 1.2. Cholesterol, LDL-C, and ASCVD S2.1.2-1. Stamler J, Wentworth D, Neaton JD. Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cholesterol, LDL-C, and ASCVD S2.1.2-1?. ### Response: 1.2. Cholesterol, LDL-C, and ASCVD S2.1.2-1. Stamler J, Wentworth D, Neaton JD. Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded.


Instruction: What is the relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded?

Output: Stamler J, Wentworth D, Neaton JD. Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356 222 primary screenees of the Multiple Risk Factor Intervention Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded?. ### Response: Stamler J, Wentworth D, Neaton JD. Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356 222 primary screenees of the Multiple Risk Factor Intervention Trial.


Instruction: How many primary screenees of the Multiple Risk Factor Intervention Trial were included in the MRFIT trial?

Output: 356 222

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many primary screenees of the Multiple Risk Factor Intervention Trial were included in the MRFIT trial?. ### Response: 356 222.


Instruction: What is MRFIT?

Output: Multiple Risk Factor Intervention Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is MRFIT?. ### Response: Multiple Risk Factor Intervention Trial.


Instruction: What is the name of the study that examined serum cholesterol, lipopro-teins, and the risk of coronary heart disease?

Output: Framingham study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined serum cholesterol, lipopro-teins, and the risk of coronary heart disease?. ### Response: Framingham study.


Instruction: Cholesterol is a major risk factor for what type of disease?

Output: coronary heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cholesterol is a major risk factor for what type of disease?. ### Response: coronary heart disease.


Instruction: When was Comparative Quantification of Health Risks: Global and Regional Burden of Disease Attributed to Selected Major Risk Factors published?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Comparative Quantification of Health Risks: Global and Regional Burden of Disease Attributed to Selected Major Risk Factors published?. ### Response: 2004.


Instruction: Geneva, Switzerland: WHO, 391–496.

Output: World Health Organization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Geneva, Switzerland: WHO, 391–496.. ### Response: World Health Organization.


Instruction: What is ezetimibe added to statin therapy after acute coronary syndromes?

Output: Ezetimibe added to statin therapy after acute coronary syndromes. N Engl J Med

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ezetimibe added to statin therapy after acute coronary syndromes?. ### Response: Ezetimibe added to statin therapy after acute coronary syndromes. N Engl J Med.


Instruction: What is the name of the meta-analysis of statin trials?

Output: Very low levels of ath-erogenic lipoproteins and the risk for cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis of statin trials?. ### Response: Very low levels of ath-erogenic lipoproteins and the risk for cardiovascular events.


Instruction: What is statin therapy after acute coronary syndromes?

Output: Ezetimibe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is statin therapy after acute coronary syndromes?. ### Response: Ezetimibe.


Instruction: What is evolocumab and clini-cal outcomes in patients with cardiovascular disease?

Output: S2.1.2-7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is evolocumab and clini-cal outcomes in patients with cardiovascular disease?. ### Response: S2.1.2-7.


Instruction: Who is Silverman MG?

Output: Ference BA, Im K

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Silverman MG?. ### Response: Ference BA, Im K.


Instruction: What is the association between lower -ing LDL-C and cardiovascular risk reduction among different thera- teria?

Output: Efficacy and safety

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association between lower -ing LDL-C and cardiovascular risk reduction among different thera- teria?. ### Response: Efficacy and safety.


Instruction: What does BA, Im K, and Im K do?

Output: Association between lower -ing LDL-C and cardiovascular risk reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does BA, Im K, and Im K do?. ### Response: Association between lower -ing LDL-C and cardiovascular risk reduction.


Instruction: What are nonpharmacological provocative tests used for?

Output: diagnostically

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are nonpharmacological provocative tests used for?. ### Response: diagnostically.


Instruction: What are potent vasoconstrictors?

Output: acetylcholine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are potent vasoconstrictors?. ### Response: acetylcholine.


Instruction: Smoking exacerbates what?

Output: coronary vasospasm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Smoking exacerbates what?. ### Response: coronary vasospasm.


Instruction: What are first-line therapies?

Output: CCBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are first-line therapies?. ### Response: CCBs.


Instruction: What are also effective when combined with CCBs?

Output: long-acting nitrates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are also effective when combined with CCBs?. ### Response: long-acting nitrates.


Instruction: Statins improve endothelium-dependent vasodilation and can be useful in what type of angina?

Output: vaso-spastic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Statins improve endothelium-dependent vasodilation and can be useful in what type of angina?. ### Response: vaso-spastic.


Instruction: Magnesium supplementation and alpha-receptor blockers can be added to what?

Output: spastic angina

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Magnesium supplementation and alpha-receptor blockers can be added to what?. ### Response: spastic angina.


Instruction: What is another term for angiographically normal or nonobstructive coronary arteries?

Output: syndrome X

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for angiographically normal or nonobstructive coronary arteries?. ### Response: syndrome X.


Instruction: What is a physiological assessment that may be considered if endothelial dysfunction is suspected?

Output: coronary flow reserve measurement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a physiological assessment that may be considered if endothelial dysfunction is suspected?. ### Response: coronary flow reserve measurement.


Instruction: What may be related to coronary endothelial dysfunction777?

Output: plaque rupture

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be related to coronary endothelial dysfunction777?. ### Response: plaque rupture.


Instruction: What is plaque rupture that may be evident only with intracoronary ultrasound778?

Output: coronary endothelial dysfunction777

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is plaque rupture that may be evident only with intracoronary ultrasound778?. ### Response: coronary endothelial dysfunction777.


Instruction: Myocarditis may present with what findings similar to ACS?

Output: elec-trocardiographic and biomarker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Myocarditis may present with what findings similar to ACS?. ### Response: elec-trocardiographic and biomarker.


Instruction: What can be distinguished by magnetic resonance imaging?

Output: Myocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be distinguished by magnetic resonance imaging?. ### Response: Myocarditis.


Instruction: Intracoronary ultrasound and/or optical coherence tomog-raphy to assess the extent of atherosclerosis and exclude what?

Output: obstructive lesions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Intracoronary ultrasound and/or optical coherence tomog-raphy to assess the extent of atherosclerosis and exclude what?. ### Response: obstructive lesions.


Instruction: What is more common in women than in men?

Output: Endothelial dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more common in women than in men?. ### Response: Endothelial dysfunction.


Instruction: What can be done after a period of stabilization?

Output: coronary angiography and provocative testing with acetylcholine, adenosine, or methacholine and 24-hour ambulatory ECG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be done after a period of stabilization?. ### Response: coronary angiography and provocative testing with acetylcholine, adenosine, or methacholine and 24-hour ambulatory ECG.


Instruction: What is the prognosis of coronary endothelial dysfunction and/or occult plaque rupture?

Output: favorable

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the prognosis of coronary endothelial dysfunction and/or occult plaque rupture?. ### Response: favorable.


Instruction: What are blockers and CCBs used for?

Output: endothelial dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are blockers and CCBs used for?. ### Response: endothelial dysfunction.


Instruction: What has been used in patients with endothelial dysfunction for contin-ued pain?

Output: Imipramine or aminophylline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been used in patients with endothelial dysfunction for contin-ued pain?. ### Response: Imipramine or aminophylline.


Instruction: In postmenopausal women, estrogen reverses what?

Output: acetylcholine-induced coronary arterial vasoconstriction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In postmenopausal women, estrogen reverses what?. ### Response: acetylcholine-induced coronary arterial vasoconstriction.


Instruction: What does estrogen reverse?

Output: acetylcholine-induced coronary arterial vasoconstriction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does estrogen reverse?. ### Response: acetylcholine-induced coronary arterial vasoconstriction.


Instruction: Why is estrogen not recommended?

Output: its demonstrated increase in cardiovascular and other risks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is estrogen not recommended?. ### Response: its demonstrated increase in cardiovascular and other risks.


Instruction: What affects a young, predominantly female population?

Output: Spontaneous coronary artery dissection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What affects a young, predominantly female population?. ### Response: Spontaneous coronary artery dissection.


Instruction: What may be reasonable in adults with coarctation of the aorta who exercise?

Output: Exercise testing to evaluate for exercise-induced hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be reasonable in adults with coarctation of the aorta who exercise?. ### Response: Exercise testing to evaluate for exercise-induced hypertension.


Instruction: Exercise testing to evaluate for exercise-induced hypertension may be what?

Output: reasonable

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Exercise testing to evaluate for exercise-induced hypertension may be what?. ### Response: reasonable.


Instruction: What type of repair or catheter-based stenting is recommended for adults with hypertension?

Output: Surgical

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of repair or catheter-based stenting is recommended for adults with hypertension?. ### Response: Surgical.


Instruction: What is recommended for treatment of hypertension in patients with coarctation of the aorta?

Output: GDMT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for treatment of hypertension in patients with coarctation of the aorta?. ### Response: GDMT.


Instruction: What type of angioplasty may be considered if stent placement is needed?

Output: Balloon

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of angioplasty may be considered if stent placement is needed?. ### Response: Balloon.


Instruction: What is the most common sequela of CoA?

Output: Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common sequela of CoA?. ### Response: Hypertension.


Instruction: What is commonly associated with CoA and is present?

Output: BAV

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is commonly associated with CoA and is present?. ### Response: BAV.


Instruction: What is BAV commonly associated with?

Output: CoA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is BAV commonly associated with?. ### Response: CoA.


Instruction: What is present in more than half of CoA patients?

Output: BAV

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is present in more than half of CoA patients?. ### Response: BAV.


Instruction: Intracranial aneu-rysms may occur.

Output: S4.2.6-15–S4.2.6-21

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Intracranial aneu-rysms may occur.. ### Response: S4.2.6-15–S4.2.6-21.


Instruction: What are often found in those with BAV?

Output: Ascending aortic aneurysms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are often found in those with BAV?. ### Response: Ascending aortic aneurysms.


Instruction: Where is repair in the descending thoracic aorta or arch?

Output: near the ductal remnant and left subclavian artery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is repair in the descending thoracic aorta or arch?. ### Response: near the ductal remnant and left subclavian artery.


Instruction: Dissection can occur, presumably more likely in the setting of what?

Output: poorly controlled hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Dissection can occur, presumably more likely in the setting of what?. ### Response: poorly controlled hypertension.


Instruction: Hypertension remains common and pre-disposes to later myocardial infarction, stroke, and what else?

Output: HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hypertension remains common and pre-disposes to later myocardial infarction, stroke, and what else?. ### Response: HF.


Instruction: What is Section 3.4 for?

Output: rec-ommendations on diagnostic evaluation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Section 3.4 for?. ### Response: rec-ommendations on diagnostic evaluation.


Instruction: What is Table 21?

Output: routine testing and follow-up intervals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Table 21?. ### Response: routine testing and follow-up intervals.


Instruction: Complications of CoA repair include recoarcta-tion, aneurysm, pseudoaneurym, and dissection?

Output: Supportive Text1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Complications of CoA repair include recoarcta-tion, aneurysm, pseudoaneurym, and dissection?. ### Response: Supportive Text1.


Instruction: What is another term for pseudoaneurysm?

Output: aneurysm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for pseudoaneurysm?. ### Response: aneurysm.


Instruction: What percentage of patients may require reintervention for restenosis?

Output: 11%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients may require reintervention for restenosis?. ### Response: 11%.


Instruction: CMR or CTA are visualized by what?

Output: physical examination findings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: CMR or CTA are visualized by what?. ### Response: physical examination findings.


Instruction: What are the results of a physical examination?

Output: Exercise testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of a physical examination?. ### Response: Exercise testing.


Instruction: When were the recommendations for coarctation of the aorta released?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When were the recommendations for coarctation of the aorta released?. ### Response: April 28, 2023.


Instruction: What is the doi:10.1038/kisup.2012.621?

Output: Kidney International Supplements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the doi:10.1038/kisup.2012.621?. ### Response: Kidney International Supplements.


Instruction: What are the K/DOQI clinical practice guidelines on?

Output: hypertension and antihypertensive agents in chronic kidney disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the K/DOQI clinical practice guidelines on?. ### Response: hypertension and antihypertensive agents in chronic kidney disease.


Instruction: When was the Am J Kidney Dis 2004?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Am J Kidney Dis 2004?. ### Response: 2005.


Instruction: What is a global public health problem?

Output: Chronic kidney disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a global public health problem?. ### Response: Chronic kidney disease.


Instruction: What is the name of the position statement from Kidney Disease Improving global outcomes?

Output: Levey AS, Atkins R, Coresh J et al. Chronic kidney disease as a globalpublic health problem: approaches and initiatives

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the position statement from Kidney Disease Improving global outcomes?. ### Response: Levey AS, Atkins R, Coresh J et al. Chronic kidney disease as a globalpublic health problem: approaches and initiatives.


Instruction: What is the blood pressure in chronic Kidney disease stage 5D-report from a Kidney Disease: Improving GlobalOutcomes controversies conference?

Output: 273– 284.5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the blood pressure in chronic Kidney disease stage 5D-report from a Kidney Disease: Improving GlobalOutcomes controversies conference?. ### Response: 273– 284.5.


Instruction: What is a systematic review and meta-analysis of antihypertensive drugs in dialysis patients?

Output: Cardiovascular protection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a systematic review and meta-analysis of antihypertensive drugs in dialysis patients?. ### Response: Cardiovascular protection.


Instruction: What is the name of the systematic review and meta-analysis of randomised controlled trials?

Output: asystematic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta-analysis of randomised controlled trials?. ### Response: asystematic.


Instruction: What does lowering blood pressure do for cardiovascular events and mortality in patients on dialysis?

Output: Effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does lowering blood pressure do for cardiovascular events and mortality in patients on dialysis?. ### Response: Effect.


Instruction: What is the KDIGO GN Work Group's clinical practice guideline for glome-rulonephritis?

Output: Kidney inter, Suppl 2012; 2:139– 274.8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the KDIGO GN Work Group's clinical practice guideline for glome-rulonephritis?. ### Response: Kidney inter, Suppl 2012; 2:139– 274.8.


Instruction: When did Kidney inter issue a guideline?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Kidney inter issue a guideline?. ### Response: 2012.


Instruction: How did Magee LA, Abalos E, von Dadelszen P et al. Control of hypertension inpregnancy?

Output: – 274.8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Magee LA, Abalos E, von Dadelszen P et al. Control of hypertension inpregnancy?. ### Response: – 274.8.


Instruction: What is the name of the 7th report of the JointNational Committee on Prevention, Detection, Evaluation, and Treat-ment of High Blood Pressure?

Output: Seventh

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 7th report of the JointNational Committee on Prevention, Detection, Evaluation, and Treat-ment of High Blood Pressure?. ### Response: Seventh.


Instruction: Hypertension 2003; 42: 1206-1252.10.

Output: dialysis patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hypertension 2003; 42: 1206-1252.10.. ### Response: dialysis patients.


Instruction: What is part 1 of the recommendations for blood pressure measurement in humans and experimental animals?

Output: a statement for professionals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is part 1 of the recommendations for blood pressure measurement in humans and experimental animals?. ### Response: a statement for professionals.


Instruction: What is the subcommittee of professional and public education of the American Heart Association Council on High Blood Pressure Research called?

Output: measurement in humans

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the subcommittee of professional and public education of the American Heart Association Council on High Blood Pressure Research called?. ### Response: measurement in humans.


Instruction: What are important in patients with chronic kidney disease?

Output: clinic and homeblood pressure recordings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are important in patients with chronic kidney disease?. ### Response: clinic and homeblood pressure recordings.


Instruction: What is the name of the journal that describes the importance of home blood pressure monitoring in CKD?

Output: Am J

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that describes the importance of home blood pressure monitoring in CKD?. ### Response: Am J.


Instruction: What does Mehls O do?

Output: Home, clinic, and ambulatory bloodpressure monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Mehls O do?. ### Response: Home, clinic, and ambulatory bloodpressure monitoring.


Instruction: What does Wuhl E, Trivelli A, Picca S, et al. do in children with chronic renal failure?

Output: Strict blood-pressure control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Wuhl E, Trivelli A, Picca S, et al. do in children with chronic renal failure?. ### Response: Strict blood-pressure control.


Instruction: How many measures did Powers BJ, Olsen MK, Smith VA and others use?

Output: blood pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many measures did Powers BJ, Olsen MK, Smith VA and others use?. ### Response: blood pressure.


Instruction: What was the name of the 2011 journal that published a study on blood pressure?

Output: Ann Intern Med

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the 2011 journal that published a study on blood pressure?. ### Response: Ann Intern Med.


Instruction: What are some of the organizations that help improve the application of clinical practice guidelines in patients with cardio-vascular disease and comorbid conditions?

Output: American Heart As-sociation, American College of Cardiology, and U.S. Department of Health and Human Services

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the organizations that help improve the application of clinical practice guidelines in patients with cardio-vascular disease and comorbid conditions?. ### Response: American Heart As-sociation, American College of Cardiology, and U.S. Department of Health and Human Services.


Instruction: What is the name of the organization that helps improve application of the guidelines?

Output: American Heart As-sociation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that helps improve application of the guidelines?. ### Response: American Heart As-sociation.


Instruction: Who is a member of the American Heart Association?

Output: American College of Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a member of the American Heart Association?. ### Response: American College of Cardiology.


Instruction: What did the American College of Cardiology/*Former Joint Committee member do?

Output: enhance application of clinical practice guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the American College of Cardiology/*Former Joint Committee member do?. ### Response: enhance application of clinical practice guidelines.


Instruction: When was the report downloaded from http://ahajournals.org?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the report downloaded from http://ahajournals.org?. ### Response: April 28, 2023.


Instruction: What is the ACC/AHA Stage 2 HBP Control SBP 140 mm Hg (Harmonizing Measure)?

Output: Controlling High Blood Pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ACC/AHA Stage 2 HBP Control SBP 140 mm Hg (Harmonizing Measure)?. ### Response: Controlling High Blood Pressure.


Instruction: What is the percentage of patients 18 to 85 years of age who had a Diagnosis of ACC/AHA Stage 2 HBP and Whose SBP Was 140 mm Hg during the Measurement Year?

Output: Percentage of patients with ACC/AHA stage 2 HBP with SBP <140 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the percentage of patients 18 to 85 years of age who had a Diagnosis of ACC/AHA Stage 2 HBP and Whose SBP Was 140 mm Hg during the Measurement Year?. ### Response: Percentage of patients with ACC/AHA stage 2 HBP with SBP <140 mm Hg.


Instruction: What does SBP 140 mm Hg harmonise with?

Output: current performance measure “Controlling High Blood Pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does SBP 140 mm Hg harmonise with?. ### Response: current performance measure “Controlling High Blood Pressure.


Instruction: What is the name of the performance measure in widespread use?

Output: QRS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the performance measure in widespread use?. ### Response: QRS.


Instruction: Who is the nominator?

Output: Patients with SBP <140 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the nominator?. ### Response: Patients with SBP <140 mm Hg.


Instruction: All patients 18-85 y of age with ACC/AHA stage 2 HBP who had at least 1 outpatient encounter with a diagnosis of HBP during the first 6 mo?

Output: All patients 18–85 y of age with ACC/AHA stage 2 HBP who had at least 1 outpatient encounter with a diagnosis of HBP during the first 6 mo of the measurement year or any time before the measurement period

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: All patients 18-85 y of age with ACC/AHA stage 2 HBP who had at least 1 outpatient encounter with a diagnosis of HBP during the first 6 mo?. ### Response: All patients 18–85 y of age with ACC/AHA stage 2 HBP who had at least 1 outpatient encounter with a diagnosis of HBP during the first 6 mo of the measurement year or any time before the measurement period.


Instruction: During the first 6 mo of the measurement year or any time before the measurement period?

Output: All patients 18–85 y of age with ACC/AHA stage 2 HBP who had at least 1 outpatient encounter with a diagnosis of HBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: During the first 6 mo of the measurement year or any time before the measurement period?. ### Response: All patients 18–85 y of age with ACC/AHA stage 2 HBP who had at least 1 outpatient encounter with a diagnosis of HBP.


Instruction: End-stage renal disease, kidney transplantation, pregnancy, BP readings taken during an inpatient stayWhat is one medical reason for a diagnosis of HBP?

Output: treatment intolerance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: End-stage renal disease, kidney transplantation, pregnancy, BP readings taken during an inpatient stayWhat is one medical reason for a diagnosis of HBP?. ### Response: treatment intolerance.


Instruction: What is a reason for treatment intolerance?

Output: significant risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a reason for treatment intolerance?. ### Response: significant risk.


Instruction: What is an example of a patient reason?

Output: economic/access issues

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a patient reason?. ### Response: economic/access issues.


Instruction: How long is the measurement period?

Output: 12 mo/measurement year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the measurement period?. ### Response: 12 mo/measurement year.


Instruction: What is a term for electronic administrative data?

Output: QRS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a term for electronic administrative data?. ### Response: QRS.


Instruction: What is an example of a telephonically transmitted BP reading?

Output: electronically

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a telephonically transmitted BP reading?. ### Response: electronically.


Instruction: What can effective management of BP in patients with hypertension help prevent?

Output: cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can effective management of BP in patients with hypertension help prevent?. ### Response: cardiovascular events.


Instruction: What can help reduce the risk of death from these complications?

Output: Effective management of BP in patients with hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can help reduce the risk of death from these complications?. ### Response: Effective management of BP in patients with hypertension.


Instruction: This performance measure harmonizes with what?

Output: Controlling High Blood Pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: This performance measure harmonizes with what?. ### Response: Controlling High Blood Pressure.


Instruction: What are some examples of QRUR used in payment programs?

Output: physician feedback

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some examples of QRUR used in payment programs?. ### Response: physician feedback.


Instruction: What is the national average rate of performance?

Output: <70%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the national average rate of performance?. ### Response: <70%.


Instruction: What is the national average rate of performance for HEDIS?

Output: <70%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the national average rate of performance for HEDIS?. ### Response: <70%.


Instruction: What should BP be classified as to prevent and treat high BP?

Output: normal, elevated, or stage 1 or 2 hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should BP be classified as to prevent and treat high BP?. ### Response: normal, elevated, or stage 1 or 2 hypertension.


Instruction: What is a class 1 level of evidence?

Output: B-NR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a class 1 level of evidence?. ### Response: B-NR.


Instruction: Out-of-office BP measurements are recommended to confirm the diagnosis of hypertension and for titration of what?

Output: BP-lowering medication

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Out-of-office BP measurements are recommended to confirm the diagnosis of hypertension and for titration of what?. ### Response: BP-lowering medication.


Instruction: What is the name of the retrospective observational study?

Output: PROSPER

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the retrospective observational study?. ### Response: PROSPER.


Instruction: What are older people's attitudes regarding polypharmacy, statin use and willingness to have statins depre-scribed in Australia?

Output: Qi K, Reeve E, Hilmer SN, et al. Older people’s attitudes regard-ing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are older people's attitudes regarding polypharmacy, statin use and willingness to have statins depre-scribed in Australia?. ### Response: Qi K, Reeve E, Hilmer SN, et al. Older people’s attitudes regard-ing.


Instruction: What are statin therapy, muscle func-tion and falls risk in community-dwelling older adults?

Output: mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are statin therapy, muscle func-tion and falls risk in community-dwelling older adults?. ### Response: mortality.


Instruction: What is the name of the systematic review of statin-drug interac-tions in older people?

Output: PROSPER study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review of statin-drug interac-tions in older people?. ### Response: PROSPER study.


Instruction: What is atorvastatin used for in Alzheimer disease?

Output: Randomized controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is atorvastatin used for in Alzheimer disease?. ### Response: Randomized controlled trial.


Instruction: What is the PROSPER study?

Output: Testing cognitive function in elderly populations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the PROSPER study?. ### Response: Testing cognitive function in elderly populations.


Instruction: What is pravastatin used for in the Elderly at Risk?

Output: Testing cognitive function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is pravastatin used for in the Elderly at Risk?. ### Response: Testing cognitive function.


Instruction: When did the J Neurol Neurosurg Psychiatry issue 73:385-9?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the J Neurol Neurosurg Psychiatry issue 73:385-9?. ### Response: 2002.


Instruction: How does statin therapy affect mortality in patients with cardiovascular disease?

Output: intensity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does statin therapy affect mortality in patients with cardiovascular disease?. ### Response: intensity.


Instruction: What is pravastatin and cogni-tive function in the elderly?

Output: Prevention of cardiovascular events and death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is pravastatin and cogni-tive function in the elderly?. ### Response: Prevention of cardiovascular events and death.


Instruction: What is the name of the randomized, double-blind, placebo-controlled trial of simvastin to treat Alzheimer disease?

Output: LEADe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized, double-blind, placebo-controlled trial of simvastin to treat Alzheimer disease?. ### Response: LEADe.


Instruction: What does statins reduce the risk of infarction in patients with heart failure?

Output: mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does statins reduce the risk of infarction in patients with heart failure?. ### Response: mortality.


Instruction: What did the PROSPER study do?

Output: Testing cognitive function in elderly populations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the PROSPER study do?. ### Response: Testing cognitive function in elderly populations.


Instruction: When was the J Neurol.257:85-90 published?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Neurol.257:85-90 published?. ### Response: 2010.


Instruction: What is rosuvastatin used for in older patients with systolic heart failure?

Output: mortality in patients with atheroscle-rotic cardiovascular disease. JAMA Cardiol. 2017;2:47–54. S4.1-35. Sano M, Bell KL, Galasko D, et al. A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is rosuvastatin used for in older patients with systolic heart failure?. ### Response: mortality in patients with atheroscle-rotic cardiovascular disease. JAMA Cardiol. 2017;2:47–54. S4.1-35. Sano M, Bell KL, Galasko D, et al. A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease.


Instruction: When did N Engl J Med issue 357:2248-61?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did N Engl J Med issue 357:2248-61?. ### Response: 2007.


Instruction: What is the GISSI-HF trial?

Output: a randomised, double-blind, placebo-controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the GISSI-HF trial?. ### Response: a randomised, double-blind, placebo-controlled trial.


Instruction: What was the name of the trial that evaluated rosuvastatin in patients with chronic heart failure?

Output: GISSI-HF trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the trial that evaluated rosuvastatin in patients with chronic heart failure?. ### Response: GISSI-HF trial.


Instruction: When was the LIPID Study Group conducted?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the LIPID Study Group conducted?. ### Response: 2008.


Instruction: Pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels?

Output: Prevention of cardiovascular events and death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels?. ### Response: Prevention of cardiovascular events and death.


Instruction: N Engl J Med. 1998; 339:1349-57. S4.1-41. What does evolocumab do?

Output: Low-density lipoprotein cholesterol lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: N Engl J Med. 1998; 339:1349-57. S4.1-41. What does evolocumab do?. ### Response: Low-density lipoprotein cholesterol lowering.


Instruction: What is the name of the FOURIER trial?

Output: Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the FOURIER trial?. ### Response: Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk.


Instruction: What is another name for Forteer Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk?

Output: FOURIER trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for Forteer Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk?. ### Response: FOURIER trial.


Instruction: When was the Circulation.137:338-50?

Output: 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circulation.137:338-50?. ### Response: 2018.


Instruction: What does therapy intensify in a population with atherosclerotic cardio-vascular disease?

Output: lipid-lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does therapy intensify in a population with atherosclerotic cardio-vascular disease?. ### Response: lipid-lowering.


Instruction: What is JAMA Cardiol. 2017;2:959-66?

Output: Simulation of lipid-lowering therapy intensification in a population with atherosclerotic cardio-vascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is JAMA Cardiol. 2017;2:959-66?. ### Response: Simulation of lipid-lowering therapy intensification in a population with atherosclerotic cardio-vascular disease.


Instruction: What is the name of the guideline for the secondary prevention of ischemic stroke?

Output: 2021 Guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the guideline for the secondary prevention of ischemic stroke?. ### Response: 2021 Guideline.


Instruction: What is AF in the setting of bioprosthetic valves?

Output: atrial fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is AF in the setting of bioprosthetic valves?. ### Response: atrial fibrillation.


Instruction: What are still considered nonvalvular valves?

Output: AF in the setting of bioprosthetic valves, mild mitral stenosis, and any native aortic, pulmonary, or tricuspid valve dis-ease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are still considered nonvalvular valves?. ### Response: AF in the setting of bioprosthetic valves, mild mitral stenosis, and any native aortic, pulmonary, or tricuspid valve dis-ease.


Instruction: What are DOACs used to prevent in patients with AF?

Output: thromboembolic complications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are DOACs used to prevent in patients with AF?. ### Response: thromboembolic complications.


Instruction: How many patients with VHD have a DOAC?

Output: 452–457

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with VHD have a DOAC?. ### Response: 452–457.


Instruction: How many meta-analyses of randomized trials were conducted in patients with VHD?

Output: 452–457

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many meta-analyses of randomized trials were conducted in patients with VHD?. ### Response: 452–457.


Instruction: What are DOACs over warfarin therapy?

Output: apixaban, dabigatran, edoxaban, and rivaroxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are DOACs over warfarin therapy?. ### Response: apixaban, dabigatran, edoxaban, and rivaroxaban.


Instruction: In patients with mechanical mitral valve replacement, anticoagulation with what drug is recommended?

Output: warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with mechanical mitral valve replacement, anticoagulation with what drug is recommended?. ### Response: warfarin.


Instruction: What is the INR target for mitral valve replacement?

Output: 3.0

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the INR target for mitral valve replacement?. ### Response: 3.0.


Instruction: What is higher in patients with mechanical prostheses in the mitral compared with the aortic position?

Output: The inci-dence of thromboembolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is higher in patients with mechanical prostheses in the mitral compared with the aortic position?. ### Response: The inci-dence of thromboembolism.


Instruction: In patients with a higher INR goal, what is the rate of thromboembolism?

Output: lower

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with a higher INR goal, what is the rate of thromboembolism?. ### Response: lower.


Instruction: What is lower in patients with a higher INR goal?

Output: rate of thrombo-embolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is lower in patients with a higher INR goal?. ### Response: rate of thrombo-embolism.


Instruction: What was associated with lower survival rates in the GELIA study?

Output: a lower INR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with lower survival rates in the GELIA study?. ### Response: a lower INR.


Instruction: What is the INR range?

Output: 2.5–3.5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the INR range?. ### Response: 2.5–3.5.


Instruction: What is not recom-mendated in patients with mechanical valves?

Output: routine addition of aspirin to warfarin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recom-mendated in patients with mechanical valves?. ### Response: routine addition of aspirin to warfarin therapy.


Instruction: Patients with a history of ischemic stroke or TIA before the mechanical valve surgery represent a group with an inherently higher thrombo-embolic risk?

Output: the protection from recurrent thromboembolic events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with a history of ischemic stroke or TIA before the mechanical valve surgery represent a group with an inherently higher thrombo-embolic risk?. ### Response: the protection from recurrent thromboembolic events.


Instruction: Aspirin and warfarin therapy may outweigh the competing bleeding risk in whom?

Output: patients with a history of ischemic stroke or TIA before the mechanical valve surgery repre-sent a group with an inherently higher thrombo-embolic risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Aspirin and warfarin therapy may outweigh the competing bleeding risk in whom?. ### Response: patients with a history of ischemic stroke or TIA before the mechanical valve surgery repre-sent a group with an inherently higher thrombo-embolic risk.


Instruction: In the absence of AF, observational studies have reported conflicting results with regard to the asso -ciation between what two conditions?

Output: nonrheumatic mitral valve disease or native aortic disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the absence of AF, observational studies have reported conflicting results with regard to the asso -ciation between what two conditions?. ### Response: nonrheumatic mitral valve disease or native aortic disease.


Instruction: What is the association between nonrheumatic mitral valve disease or native aortic disease and increased risk of throm -boembolic complications?

Output: asso -ciation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association between nonrheumatic mitral valve disease or native aortic disease and increased risk of throm -boembolic complications?. ### Response: asso -ciation.


Instruction: What did an early case-con-trol study report that withral valve prolapse was associated with an increased risk for?

Output: ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did an early case-con-trol study report that withral valve prolapse was associated with an increased risk for?. ### Response: ischemic stroke.


Instruction: What is the risk for stroke in people with mitral valve prolapse?

Output: <1% annually

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk for stroke in people with mitral valve prolapse?. ### Response: <1% annually.


Instruction: How many population-based cohort studies have evaluated the association between mitral annular calcification and stroke?

Output: 4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many population-based cohort studies have evaluated the association between mitral annular calcification and stroke?. ### Response: 4.


Instruction: How many strokes were there in Figure 3?

Output: 2.5–4.5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes were there in Figure 3?. ### Response: 2.5–4.5.


Instruction: What is TIA?

Output: ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is TIA?. ### Response: ischemic stroke.


Instruction: How do colors correspond to Class of Recommendation?

Output: Table 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do colors correspond to Class of Recommendation?. ### Response: Table 3.


Instruction: Abx indicates what?

Output: antibiotics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Abx indicates what?. ### Response: antibiotics.


Instruction: What did Lindahl and associates isolate with high affi nity for AT, Choay, and others?

Output: heparin fragments

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Lindahl and associates isolate with high affi nity for AT, Choay, and others?. ### Response: heparin fragments.


Instruction: What was the name of the SUPPLEMENT e33S?

Output: 1.3 Fondaparinux

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the SUPPLEMENT e33S?. ### Response: 1.3 Fondaparinux.


Instruction: Choay and colleagues 192 and Thunberg et al 193 demonstrated that the minimum heparin fragment necessary for high affi nity binding to AT consisted of what?

Output: a pentasaccharide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Choay and colleagues 192 and Thunberg et al 193 demonstrated that the minimum heparin fragment necessary for high affi nity binding to AT consisted of what?. ### Response: a pentasaccharide.


Instruction: Choai and associates 125,194 demonstrated that what was the minimum of a pentasaccharide?

Output: heparin fragment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Choai and associates 125,194 demonstrated that what was the minimum of a pentasaccharide?. ### Response: heparin fragment.


Instruction: Choay and associates 125,194 isolated what high-affi nity pen-tasaccharide?

Output: pentasaccharide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Choay and associates 125,194 isolated what high-affi nity pen-tasaccharide?. ### Response: pentasaccharide.


Instruction: What was demonstrated to form an equimolar complex with AT and enhanced AT-mediated inhibition of factor Xa?

Output: high-afﬁ  nity pen-tasaccharide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was demonstrated to form an equimolar complex with AT and enhanced AT-mediated inhibition of factor Xa?. ### Response: high-afﬁ  nity pen-tasaccharide.


Instruction: What residues in the pentasac-charide sequence were critical for fondaparinux's activity?

Output: 3- O - and 6- O -sulfated glucosamine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What residues in the pentasac-charide sequence were critical for fondaparinux's activity?. ### Response: 3- O - and 6- O -sulfated glucosamine.


Instruction: What is a synthetic analog of the AT-binding peptide found in heparin?

Output: Fonda-parinux

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a synthetic analog of the AT-binding peptide found in heparin?. ### Response: Fonda-parinux.


Instruction: How did the observations of the 3- O- and 6- O-sulfated glucosamine residues pave the way for the development of fondaparainux?

Output: critical for its activity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did the observations of the 3- O- and 6- O-sulfated glucosamine residues pave the way for the development of fondaparainux?. ### Response: critical for its activity.


Instruction: What is the molec-ular weight of fondaparinux?

Output: 1,728

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the molec-ular weight of fondaparinux?. ### Response: 1,728.


Instruction: What is a synthetic analog of the AT-binding pentasaccharide found in heparin?

Output: fondaparinux

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a synthetic analog of the AT-binding pentasaccharide found in heparin?. ### Response: fondaparinux.


Instruction: What is fondaparainux's specifi c anti-Xa activity higher than than?

Output: LMWH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is fondaparainux's specifi c anti-Xa activity higher than than?. ### Response: LMWH.


Instruction: How long is the half-life after sub-cutaneous injection?

Output: 17 h and about 4 h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the half-life after sub-cutaneous injection?. ### Response: 17 h and about 4 h.


Instruction: How long does LMWH last?

Output: 17 h and about 4 h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does LMWH last?. ### Response: 17 h and about 4 h.


Instruction: What is the time period used to determine the anti-Xa activity of fondaparinux?

Output: LMWH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the time period used to determine the anti-Xa activity of fondaparinux?. ### Response: LMWH.


Instruction: What is used to generate the stan-dard curve?

Output: fondaparinux concentrations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used to generate the stan-dard curve?. ### Response: fondaparinux concentrations.


Instruction: What does fondaparinux bind to?

Output: AT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does fondaparinux bind to?. ### Response: AT.


Instruction: Where does Fondaparainux produce a confor-mational change?

Output: reactive site of AT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where does Fondaparainux produce a confor-mational change?. ### Response: reactive site of AT.


Instruction: How does 198 AT form a covalent complex?

Output: factor Xa.  198   AT then forms a covalent complex with factor Xa

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does 198 AT form a covalent complex?. ### Response: factor Xa.  198   AT then forms a covalent complex with factor Xa.


Instruction: Fonda-parinux is released from AT and is available to acti-vate additional AT molecules.

Output: reactive site of AT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Fonda-parinux is released from AT and is available to acti-vate additional AT molecules.. ### Response: reactive site of AT.


Instruction: Fonda parinux does not increase the rate of what by AT?

Output: thrombin inhibition

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Fonda parinux does not increase the rate of what by AT?. ### Response: thrombin inhibition.


Instruction: What has been studied in healthy volun-teers?

Output: The pharmacokinetic properties and metabolism of fondaparinux

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been studied in healthy volun-teers?. ### Response: The pharmacokinetic properties and metabolism of fondaparinux.


Instruction: What is rapidly and completely absorbed after subcutaneous injection?

Output: fondaparinux

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is rapidly and completely absorbed after subcutaneous injection?. ### Response: fondaparinux.


Instruction: After the third or fourth once-daily dose, what is excreted unchanged in the urine?

Output: fondaparinux

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: After the third or fourth once-daily dose, what is excreted unchanged in the urine?. ### Response: fondaparinux.


Instruction: What is excreted unchanged in the urine?

Output: fondaparinux

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is excreted unchanged in the urine?. ### Response: fondaparinux.


Instruction: How long is the terminal half-life of fondaparinux in young subjects?

Output: 17 h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the terminal half-life of fondaparinux in young subjects?. ### Response: 17 h.


Instruction: In elderly volunteers, how long is it in terminally ill volunteers?

Output: 21 h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In elderly volunteers, how long is it in terminally ill volunteers?. ### Response: 21 h.


Instruction: What is the predict-able anticoagulant response when given subcutaneously?

Output: linear phar-macokinetics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the predict-able anticoagulant response when given subcutaneously?. ### Response: linear phar-macokinetics.


Instruction: What is the dose range of fondaparinux in IV doses?

Output: 2 to 20 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the dose range of fondaparinux in IV doses?. ### Response: 2 to 20 mg.


Instruction: What was the dose-dependent decrease in cancellous bone volume in rats?

Output: There is minimal nonspeciﬁ  c binding of fondaparinux

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the dose-dependent decrease in cancellous bone volume in rats?. ### Response: There is minimal nonspeciﬁ  c binding of fondaparinux.


Instruction: With UFH, what was the effect greater?

Output: LMWH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: With UFH, what was the effect greater?. ### Response: LMWH.


Instruction: What was greater with UFH than with LMWH?

Output: the effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was greater with UFH than with LMWH?. ### Response: the effects.


Instruction: What is the name of the reference list for Chronic Heart Failure?

Output: NICE 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the reference list for Chronic Heart Failure?. ### Response: NICE 2018.


Instruction: Who is the author of this reference list?

Output: Shah AM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of this reference list?. ### Response: Shah AM.


Instruction: What type of telemonitoring does Scherr use?

Output: home -based

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of telemonitoring does Scherr use?. ### Response: home -based.


Instruction: What did Schou M, Gislason G, Videbaek L, Kober L, Tuxen C, and Torp -Pedersen do?

Output: extended follow -up in a specialized heart failure clinic on adherence to guideline recommended therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Schou M, Gislason G, Videbaek L, Kober L, Tuxen C, and Torp -Pedersen do?. ### Response: extended follow -up in a specialized heart failure clinic on adherence to guideline recommended therapy.


Instruction: What was the effect of home based telemonitoring using mobile phone technology?

Output: the outcome of heart failure patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the effect of home based telemonitoring using mobile phone technology?. ### Response: the outcome of heart failure patients.


Instruction: What did the NorthStar Adherence Study do?

Output: Effect of extended follow -up in a specialized heart failure clinic on adherence to guideline recommended therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the NorthStar Adherence Study do?. ### Response: Effect of extended follow -up in a specialized heart failure clinic on adherence to guideline recommended therapy.


Instruction: What did Schou M, Gustafsson F, Videbaek L, Kober L, Tuxen C, Torp -Pedersen C do? What was the European Journal of Heart Failure 2014?

Output: Effect of extended follow -up in a specialized heart failure clinic on adherence to guideline recommended therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Schou M, Gustafsson F, Videbaek L, Kober L, Tuxen C, Torp -Pedersen C do? What was the European Journal of Heart Failure 2014?. ### Response: Effect of extended follow -up in a specialized heart failure clinic on adherence to guideline recommended therapy.


Instruction: What did Schou M, Gustafsson F, Videbaek L, Andersen H, Toft J, Nyvad O, et al. add to optimal clinical management in outpatients with systolic heart failure: a m ulticentre randomized clinical trial?

Output: serial N -terminal pro brain natriuretic peptide measurements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Schou M, Gustafsson F, Videbaek L, Andersen H, Toft J, Nyvad O, et al. add to optimal clinical management in outpatients with systolic heart failure: a m ulticentre randomized clinical trial?. ### Response: serial N -terminal pro brain natriuretic peptide measurements.


Instruction: What is the name of the randomized clinical trial in low-risk patien ts?

Output: NorthStar

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized clinical trial in low-risk patien ts?. ### Response: NorthStar.


Instruction: What does NorthStar stand for?

Output: NorthStar Adherence Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does NorthStar stand for?. ### Response: NorthStar Adherence Study.


Instruction: When did the European Journal of Heart Failure issue 15(7):818-27 300?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the European Journal of Heart Failure issue 15(7):818-27 300?. ### Response: 2013.


Instruction: What is the name of the randomized clinical trial?

Output: NorthStar monitoring study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized clinical trial?. ### Response: NorthStar monitoring study.


Instruction: What is a pilot randomized controlled trial of?

Output: Telemonitoring of heart failure patients and their caregivers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a pilot randomized controlled trial of?. ### Response: Telemonitoring of heart failure patients and their caregivers.


Instruction: What is the name of the study that aimed to improve end-of-life care for patients with chronic heart failure?

Output: NorthStar Adherence Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that aimed to improve end-of-life care for patients with chronic heart failure?. ### Response: NorthStar Adherence Study.


Instruction: How many people were diagnosed with heart failure in 2008?

Output: 163

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were diagnosed with heart failure in 2008?. ### Response: 163.


Instruction: What year did Heart. 2007:93(8):963-7303?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Heart. 2007:93(8):963-7303?. ### Response: 2007.


Instruction: What does BNP stand for?

Output: Natriuretic Peptide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does BNP stand for?. ### Response: Natriuretic Peptide.


Instruction: What is the BNP Precursor called?

Output: proBNP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the BNP Precursor called?. ### Response: proBNP.


Instruction: How does the N-Terminal Part Matter?

Output: Different Susceptibility of B -Type Natriuretic Peptide (BNP) and BNP Precursor (proBNP) to Cleavage by Neprilysin: The N -Terminal Part Does Matter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does the N-Terminal Part Matter?. ### Response: Different Susceptibility of B -Type Natriuretic Peptide (BNP) and BNP Precursor (proBNP) to Cleavage by Neprilysin: The N -Terminal Part Does Matter.