Instruction: What is strokeIschemic, hemorrhagicWC 5th vs 1st quintileHR: 1.77 (1.53-2.05) NAWHR 5th and 1 stquintileWSR 5th, respectively, are 1.59 (1.37-2.85) and 1.91 (1.61-2.27)NANALu304Sweden 33 578 Mean: 11Prospective cohortClinically defined strokeHyperrhagicWC 4th, HR

Output: Prospective cohortClinically defined

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is strokeIschemic, hemorrhagicWC 5th vs 1st quintileHR: 1.77 (1.53-2.05) NAWHR 5th and 1 stquintileWSR 5th, respectively, are 1.59 (1.37-2.85) and 1.91 (1.61-2.27)NANALu304Sweden 33 578 Mean: 11Prospective cohortClinically defined strokeHyperrhagicWC 4th, HR. ### Response: Prospective cohortClinically defined.


Instruction: What is the difference between WSR 5th and 1st quintileHR: 2.3 (1.2–4.3)HR: 2.5 (1.3–4.2)NANANAFurukawa313Japan 5474 Mean: 11.7Prospective cohortClinically defined stroke#Not stated WC 4th vs what quartileHR: 2.64 (1.16–6.03) HR: 1.40 (0.82–2.41)CI indicates what?

Output: 1.59

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between WSR 5th and 1st quintileHR: 2.3 (1.2–4.3)HR: 2.5 (1.3–4.2)NANANAFurukawa313Japan 5474 Mean: 11.7Prospective cohortClinically defined stroke#Not stated WC 4th vs what quartileHR: 2.64 (1.16–6.03) HR: 1.40 (0.82–2.41)CI indicates what?. ### Response: 1.59.


Instruction: What is NA?

Output: not applicable

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NA?. ### Response: not applicable.


Instruction: What is TIA?

Output: transient ischemic attack

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is TIA?. ### Response: transient ischemic attack.


Instruction: How is the waist circumference adjusted?

Output: WC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the waist circumference adjusted?. ### Response: WC.


Instruction: What is the risk of metabolic syndrome for stroke not greater than?

Output: the sum of its components

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of metabolic syndrome for stroke not greater than?. ### Response: the sum of its components.


Instruction: What is a cohort study?

Output: Suita study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a cohort study?. ### Response: Suita study.


Instruction: What is not greater than the sum of its components?

Output: Risk of metabolic syndrome for stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not greater than the sum of its components?. ### Response: Risk of metabolic syndrome for stroke.


Instruction: What is the Thai Epidemiologic Stroke (TES) Study?

Output: not greater than the sum of its components

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Thai Epidemiologic Stroke (TES) Study?. ### Response: not greater than the sum of its components.


Instruction: How does the risk of metabolic syndrome for stroke compare to other factors?

Output: not greater than the sum of its components

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does the risk of metabolic syndrome for stroke compare to other factors?. ### Response: not greater than the sum of its components.


Instruction: What was the third national health and nutrition examination survey?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the third national health and nutrition examination survey?. ### Response: 2004.


Instruction: What is the metabolic syndrome associated with in the Third National Health and Nutrition Examination Survey?

Output: history of myocardial infarc-tion and stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the metabolic syndrome associated with in the Third National Health and Nutrition Examination Survey?. ### Response: history of myocardial infarc-tion and stroke.


Instruction: What is the risk for first-ever acute ischemic nonembolic stroke in elderly subjects?

Output: evenos J, Seferiadis K, Mikhailidis DP, Elisaf MS. Components of the metabolic syndrome and risk for first-ever acute ischemic nonembolic stroke in elderly subjects. Stroke. 2005;36:1372–1376. 645

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk for first-ever acute ischemic nonembolic stroke in elderly subjects?. ### Response: evenos J, Seferiadis K, Mikhailidis DP, Elisaf MS. Components of the metabolic syndrome and risk for first-ever acute ischemic nonembolic stroke in elderly subjects. Stroke. 2005;36:1372–1376. 645.


Instruction: What was the name of the relationship between metabolic syndrome and spontaneous intracerebral hemorrhage?

Output: MetS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the relationship between metabolic syndrome and spontaneous intracerebral hemorrhage?. ### Response: MetS.


Instruction: What predicts cardio and cerebrovascular events in a twenty year follow-up?

Output: Metabolic syndrome (MetS)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What predicts cardio and cerebrovascular events in a twenty year follow-up?. ### Response: Metabolic syndrome (MetS).


Instruction: What is Metabolic syndrome?

Output: predicts cardio and cerebrovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Metabolic syndrome?. ### Response: predicts cardio and cerebrovascular events.


Instruction: How long does MetS follow up?

Output: twenty years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does MetS follow up?. ### Response: twenty years.


Instruction: What does metabolic syndrome and general obesity have on the risk of ischemic stroke?

Output: Influence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does metabolic syndrome and general obesity have on the risk of ischemic stroke?. ### Response: Influence.


Instruction: What is the name of the prospective cohort study in patients with atherosclerotic cardiovascular disease?

Output: Suita study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective cohort study in patients with atherosclerotic cardiovascular disease?. ### Response: Suita study.


Instruction: What is the name of the study in patients with atherosclerotic cardiovascular disease?

Output: prospec-tive cohort study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study in patients with atherosclerotic cardiovascular disease?. ### Response: prospec-tive cohort study.


Instruction: What are the names of the studies in middle-aged men?

Output: even

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the studies in middle-aged men?. ### Response: even.


Instruction: What is a risk factor for stroke in type 2 diabetes mellitus?

Output: Metabolic syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for stroke in type 2 diabetes mellitus?. ### Response: Metabolic syndrome.


Instruction: What is the Framingham Offspring Study?

Output: Metabolic syndrome compared with type 2 diabetes mellitus as a risk factor for stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Framingham Offspring Study?. ### Response: Metabolic syndrome compared with type 2 diabetes mellitus as a risk factor for stroke.


Instruction: What is the name of the systematic review and meta-analysis of the metabolic syndrome and cardiovas-cular risk?

Output: J Am Coll Cardiol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta-analysis of the metabolic syndrome and cardiovas-cular risk?. ### Response: J Am Coll Cardiol.


Instruction: When did the J Am Coll Cardiol. 2006:56:1113–1132. 652. Okamura T, Watanabe M, Higashiyama A, Ono Y, Nishimura K, Okayama A, Miyamoto Y and Eisenberg MJ present a revised definition of what?

Output: metabolic syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the J Am Coll Cardiol. 2006:56:1113–1132. 652. Okamura T, Watanabe M, Higashiyama A, Ono Y, Nishimura K, Okayama A, Miyamoto Y and Eisenberg MJ present a revised definition of what?. ### Response: metabolic syndrome.


Instruction: What predicts coronary artery disease and ischemic stroke after adjusting for low density lipoprotein cholesterol?

Output: A revised definition of the metabolic syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What predicts coronary artery disease and ischemic stroke after adjusting for low density lipoprotein cholesterol?. ### Response: A revised definition of the metabolic syndrome.


Instruction: How long was the Suita study?

Output: 13-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the Suita study?. ### Response: 13-year.


Instruction: What is the impact of metabolic syndrome indepen-dent of insulin resistance on the development of cardiovascular disease?

Output: coronary artery disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact of metabolic syndrome indepen-dent of insulin resistance on the development of cardiovascular disease?. ### Response: coronary artery disease.


Instruction: Circ J. 2012;76:2443–2448

Output: 653

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circ J. 2012;76:2443–2448. ### Response: 653.


Instruction: What drug was used to treat hypertension in patients with CAD 1381ramipril or placebo?

Output: ACE inhibitor perindopril

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug was used to treat hypertension in patients with CAD 1381ramipril or placebo?. ### Response: ACE inhibitor perindopril.


Instruction: What was the mean follow-up time for patients with hypertension?

Output: 5.0 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean follow-up time for patients with hypertension?. ### Response: 5.0 years.


Instruction: How much reduction in the composite end point of car -diovascular death, MI, and stroke did treatment with ramiprol cause?

Output: 22%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much reduction in the composite end point of car -diovascular death, MI, and stroke did treatment with ramiprol cause?. ### Response: 22%.


Instruction: When did Rosendorff and colleagues follow up with placebo for 5.0 years?

Output: 1381ramipril (10 mg once nightly

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Rosendorff and colleagues follow up with placebo for 5.0 years?. ### Response: 1381ramipril (10 mg once nightly.


Instruction: What was the end point of car -diovascular death, MI, and stroke?

Output: P <0.001

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the end point of car -diovascular death, MI, and stroke?. ### Response: P <0.001.


Instruction: What was a significant reduction in the rates of revascu-larization, cardiac arrest, HF, worsening angina, and all-cause mortality?

Output: ramipril therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a significant reduction in the rates of revascu-larization, cardiac arrest, HF, worsening angina, and all-cause mortality?. ### Response: ramipril therapy.


Instruction: What was the mean reduction in the clinic BP with active treatment?

Output: 3/2 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean reduction in the clinic BP with active treatment?. ### Response: 3/2 mm Hg.


Instruction: What was initially thought to be independent of BP?

Output: car -diovascular benefits

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was initially thought to be independent of BP?. ### Response: car -diovascular benefits.


Instruction: A small but interesting substudy105 revealed a more marked reduction in what?

Output: 24-hour ambulatory BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A small but interesting substudy105 revealed a more marked reduction in what?. ### Response: 24-hour ambulatory BP.


Instruction: How many patients were randomized to the ACE inhibitor perindopril or placebo?

Output: 12 218

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were randomized to the ACE inhibitor perindopril or placebo?. ### Response: 12 218.


Instruction: What percentage of patients were classified as hypertensive?

Output: Forty-six percent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients were classified as hypertensive?. ### Response: Forty-six percent.


Instruction: What was the definition of hypertension based on?

Output: a clinic BP >160/95 mm Hg or antihypertensive therapy at baseline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the definition of hypertension based on?. ### Response: a clinic BP >160/95 mm Hg or antihypertensive therapy at baseline.


Instruction: How long was the mean follow-up in EUROPA?

Output: 4.2 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the mean follow-up in EUROPA?. ### Response: 4.2 years.


Instruction: What was associated with a 20% relative risk reduction in the composite end point of cardiovascular?

Output: Treatment with perindopril

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with a 20% relative risk reduction in the composite end point of cardiovascular?. ### Response: Treatment with perindopril.


Instruction: What was the relative risk reduction in the composite end point of cardiovascular death, MI, or cardiac arrest?

Output: 20%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the relative risk reduction in the composite end point of cardiovascular death, MI, or cardiac arrest?. ### Response: 20%.


Instruction: What did the investigators define as the benefit of active treat-ment with perindopril?

Output: similar for patients with or without hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the investigators define as the benefit of active treat-ment with perindopril?. ### Response: similar for patients with or without hypertension.


Instruction: The mean reduction in BP in the clinic setting was what?

Output: 3/2 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The mean reduction in BP in the clinic setting was what?. ### Response: 3/2 mm Hg.


Instruction: What was the BP in the clinic setting?

Output: 3/2 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the BP in the clinic setting?. ### Response: 3/2 mm Hg.


Instruction: What were EUROPA patients at lower cardiovascular risk than HOPE patients?

Output: At baseline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were EUROPA patients at lower cardiovascular risk than HOPE patients?. ### Response: At baseline.


Instruction: How many were 55 years of age?

Output: <55 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many were 55 years of age?. ### Response: <55 years of age.


Instruction: What was the median follow-up for patients in the PEACE trial106?

Output: 4.8 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the median follow-up for patients in the PEACE trial106?. ### Response: 4.8 years.


Instruction: What is the target dose of trandolapril?

Output: 4 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the target dose of trandolapril?. ### Response: 4 mg.


Instruction: How long was the median follow-up?

Output: 4.8 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the median follow-up?. ### Response: 4.8 years.


Instruction: What was the primary compos-ite end point of cardiovascular death, MI, or coronary artery revascularization?

Output: No difference between the groups was found in the incidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary compos-ite end point of cardiovascular death, MI, or coronary artery revascularization?. ### Response: No difference between the groups was found in the incidence.


Instruction: How many percent of patients were hyper-tensive?

Output: 27%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many percent of patients were hyper-tensive?. ### Response: 27%.


Instruction: Trandolapril was associated with a mean reduction in what?

Output: BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Trandolapril was associated with a mean reduction in what?. ### Response: BP.


Instruction: What was the annualized rate of all-cause mortality in PEACE?

Output: 1.6%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the annualized rate of all-cause mortality in PEACE?. ### Response: 1.6%,.


Instruction: What was a rate similar to that of an age- and sex-matched cohort without IHD?

Output: 1.6%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a rate similar to that of an age- and sex-matched cohort without IHD?. ### Response: 1.6%,.


Instruction: What may have contributed to the low event rate?

Output: high use of revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may have contributed to the low event rate?. ### Response: high use of revascularization.


Instruction: What might not be necessary as routine therapy in low-risk IHD patients with preserved LV function?

Output: ACE inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What might not be necessary as routine therapy in low-risk IHD patients with preserved LV function?. ### Response: ACE inhibitors.


Instruction: What type of LV function is preserved in patients who have received intensive treatment with revascularization and lipid-lower -?

Output: low-risk IHD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of LV function is preserved in patients who have received intensive treatment with revascularization and lipid-lower -?. ### Response: low-risk IHD.


Instruction: What is a joint report of the American College of Radiology Appropriateness Criteria Committee?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a joint report of the American College of Radiology Appropriateness Criteria Committee?. ### Response: 2013.


Instruction: What is the name of the joint report?

Output: National Committee on Prevention, Detection, Evaluation,and Treatment of High Blood Pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the joint report?. ### Response: National Committee on Prevention, Detection, Evaluation,and Treatment of High Blood Pressure.


Instruction: Who is the co-author of the 2013 ACCF/ACR/ASE/ASNC/SCCT/SCMR?

Output: Abbara S

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the co-author of the 2013 ACCF/ACR/ASE/ASNC/SCCT/SCMR?. ### Response: Abbara S.


Instruction: What year did the American College of Cardiology Foundation report on appropriate use criteria for coronaryrevascularization?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did the American College of Cardiology Foundation report on appropriate use criteria for coronaryrevascularization?. ### Response: 2012.


Instruction: What is the name of the task force that reviewed the appropriate use of criteria?

Output: American College ofCardiology Foundation Appropriate Use Criteria Task Force

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the task force that reviewed the appropriate use of criteria?. ### Response: American College ofCardiology Foundation Appropriate Use Criteria Task Force.


Instruction: Who is the American Association for Thoracic Surgery?

Output: Society of ThoracicSurgeons

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the American Association for Thoracic Surgery?. ### Response: Society of ThoracicSurgeons.


Instruction: What is the seventh report of the Joint National Committee on Prevention, Detection, Evaluation,and Treatment of High Blood Pressure?

Output: Chobanian AV, Bakris GL, Black HR, et al. Seventh report ofthe Joint National Committee on Prevention, Detection, Evaluation,and Treatment of High Blood Pressure. Hypertension 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the seventh report of the Joint National Committee on Prevention, Detection, Evaluation,and Treatment of High Blood Pressure?. ### Response: Chobanian AV, Bakris GL, Black HR, et al. Seventh report ofthe Joint National Committee on Prevention, Detection, Evaluation,and Treatment of High Blood Pressure. Hypertension 2003.


Instruction: What is the Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure?

Output: Joint National Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure?. ### Response: Joint National Committee.


Instruction: What was the third report of the National Cholesterol Education Program?

Output: Expert Panel on Detection, Evaluation, and Treatment of High BloodCholesterol in Adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the third report of the National Cholesterol Education Program?. ### Response: Expert Panel on Detection, Evaluation, and Treatment of High BloodCholesterol in Adults.


Instruction: What is a scienti fic statement from the American Heart Association?

Output: Decision making inadvanced heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a scienti fic statement from the American Heart Association?. ### Response: Decision making inadvanced heart failure.


Instruction: What is the name of the presidential advisory?

Output: AmericanHeart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the presidential advisory?. ### Response: AmericanHeart Association.


Instruction: When was the Circulation 2011?

Output: 124:2951

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circulation 2011?. ### Response: 124:2951.


Instruction: What are the recommendations for the use of mechanical circulatory support?

Output: device strategies and patientselection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the recommendations for the use of mechanical circulatory support?. ### Response: device strategies and patientselection.


Instruction: What is the name of the American Heart Association's position statement on advanced chronic heartfailure?

Output: Study Group on Advanced HeartFailure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the American Heart Association's position statement on advanced chronic heartfailure?. ### Response: Study Group on Advanced HeartFailure.


Instruction: When did the Eur J Heart Fail 2007 issue 9:684–94.34?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Eur J Heart Fail 2007 issue 9:684–94.34?. ### Response: 2007.


Instruction: What year did Fail occur?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Fail occur?. ### Response: 2013.


Instruction: What is the name of the scientific advisory for healthcare professionals from the American Heart Associ-ation/American Stroke Association?

Output: Oral antithrombotic agentsfor the prevention of stroke in nonvalvular atrial ﬁbrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the scientific advisory for healthcare professionals from the American Heart Associ-ation/American Stroke Association?. ### Response: Oral antithrombotic agentsfor the prevention of stroke in nonvalvular atrial ﬁbrillation.


Instruction: What is the third universal de finition ofmyocardial infarction?

Output: Adult Treatment Panel III

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the third universal de finition ofmyocardial infarction?. ### Response: Adult Treatment Panel III.


Instruction: What was the J Am Coll Cardiol 2012:60:1581 –98.36?

Output: Third universal de ﬁnition ofmyocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the J Am Coll Cardiol 2012:60:1581 –98.36?. ### Response: Third universal de ﬁnition ofmyocardial infarction.


Instruction: Who is Hunt SA, Abraham WT?

Output: Chin MH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Hunt SA, Abraham WT?. ### Response: Chin MH.


Instruction: What year was the OPTIMIZE-HF Registry published?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the OPTIMIZE-HF Registry published?. ### Response: 2007.


Instruction: What is the VA/DoD Clinical Practice Guideline for the Diagnosis and Management of Hypertension in the Primary Care Setting March 2020 Page 10 of 134 providers within the VA and DoD healthcare systems?

Output: KQs) of the most clinical relevance, importance, and interest for the diagnosis  and management of patients with HTN . The Champions and the Work Group also provided direction on inclusion and exclusion criteria for the evidence review and assessed  the level and quality of the evidence. The amount of new scientific evidence that had accumulated since the previous version of the CPG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for the Diagnosis and Management of Hypertension in the Primary Care Setting March 2020 Page 10 of 134 providers within the VA and DoD healthcare systems?. ### Response: KQs) of the most clinical relevance, importance, and interest for the diagnosis  and management of patients with HTN . The Champions and the Work Group also provided direction on inclusion and exclusion criteria for the evidence review and assessed  the level and quality of the evidence. The amount of new scientific evidence that had accumulated since the previous version of the CPG.


Instruction: What are the Champions and Workforces?

Output: Identifying  appropriate disciplines of individuals to be included as part of the Work Group  • Directing and coordinating the Work Group  • Participating throughout the guideline development and review processes  The VA Office of Quality, Safety and Value, in collaboration with the Office of Evidence Based Practice, U.S. Army Medical Command, the proponent for CPGs for the DoD, identified four  clinical leaders

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Champions and Workforces?. ### Response: Identifying  appropriate disciplines of individuals to be included as part of the Work Group  • Directing and coordinating the Work Group  • Participating throughout the guideline development and review processes  The VA Office of Quality, Safety and Value, in collaboration with the Office of Evidence Based Practice, U.S. Army Medical Command, the proponent for CPGs for the DoD, identified four  clinical leaders.


Instruction: Who were responsible for identifying the most clinical relevance, importance, and interest for the diagnosis and management of patients with HTN?

Output: the Champions and Work Group members

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who were responsible for identifying the most clinical relevance, importance, and interest for the diagnosis and management of patients with HTN?. ### Response: the Champions and Work Group members.


Instruction: What did the Champions and the Work Group provide?

Output: direction on inclusion and exclusion criteria for the evidence review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Champions and the Work Group provide?. ### Response: direction on inclusion and exclusion criteria for the evidence review.


Instruction: Who provided direction on inclusion and exclusion criteria for the evidence review?

Output: The Champions and the Work Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who provided direction on inclusion and exclusion criteria for the evidence review?. ### Response: The Champions and the Work Group.


Instruction: Who assessed the level and quality of the evidence?

Output: The Champions and the Work Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who assessed the level and quality of the evidence?. ### Response: The Champions and the Work Group.


Instruction: The amount of new scientific evidence that had accumulated since the previous version of the CPG was taken into account?

Output: identification of the KQs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The amount of new scientific evidence that had accumulated since the previous version of the CPG was taken into account?. ### Response: identification of the KQs.


Instruction: What was also taken into consideration in the identification of the KQs?

Output: The amount of new scientific evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was also taken into consideration in the identification of the KQs?. ### Response: The amount of new scientific evidence.


Instruction: What did the Champions assist in?

Output: Identifying  appropriate disciplines of individuals to be included as part of the Work Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Champions assist in?. ### Response: Identifying  appropriate disciplines of individuals to be included as part of the Work Group.


Instruction: How many CPGs did the VA Office of Quality, Safety and Value identify for the DoD?

Output: four

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many CPGs did the VA Office of Quality, Safety and Value identify for the DoD?. ### Response: four.


Instruction: What is the name of the organization that is responsible for the development of CPG guidelines?

Output: The Lewin Team

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that is responsible for the development of CPG guidelines?. ### Response: The Lewin Team.


Instruction: Who is the proponent of the CPG program?

Output: U.S. Army Medical Command

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the proponent of the CPG program?. ### Response: U.S. Army Medical Command.


Instruction: How many PGs were identified by the VA?

Output: 134

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many PGs were identified by the VA?. ### Response: 134.


Instruction: How many clinical leaders did the proponent of CPGs for the DoD identify as Champions for?

Output: four

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many clinical leaders did the proponent of CPGs for the DoD identify as Champions for?. ### Response: four.


Instruction: What are the names of the four clinical leaders from the VA?

Output: William Cushman, MD and Dan Berlowitz, MD, MPH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the four clinical leaders from the VA?. ### Response: William Cushman, MD and Dan Berlowitz, MD, MPH.


Instruction: Who were the Champions for the 2020 VA/DoD HTN CPG?

Output: four  clinical leaders

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who were the Champions for the 2020 VA/DoD HTN CPG?. ### Response: four  clinical leaders.


Instruction: What did the VA and DoD contract The Lewin Team to support?

Output: development of this CPG and conduct the evidence review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the VA and DoD contract The Lewin Team to support?. ### Response: development of this CPG and conduct the evidence review.


Instruction: What did the VA and DoD do to support the development of this CPG and conduct the evidence review?

Output: Formulating and prioritizing KQs and defining critical outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the VA and DoD do to support the development of this CPG and conduct the evidence review?. ### Response: Formulating and prioritizing KQs and defining critical outcomes.


Instruction: When was the first conference call held?

Output: October  2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the first conference call held?. ### Response: October  2018.


Instruction: What was the name of the COR?

Output: contracting officer’s representative

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the COR?. ### Response: contracting officer’s representative.


Instruction: What is the DoD Office of Evidence Based Practice called?

Output: Champions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the DoD Office of Evidence Based Practice called?. ### Response: Champions.


Instruction: What are the roles and responsibilities of the Champions?

Output: identifying the key questions (KQs) of the most clinical relevance, importance, and interest for the diagnosis  and management of patients with HTN

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the roles and responsibilities of the Champions?. ### Response: identifying the key questions (KQs) of the most clinical relevance, importance, and interest for the diagnosis  and management of patients with HTN.


Instruction: What is SR?

Output: systematic review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SR?. ### Response: systematic review.


Instruction: What did the group identify that are important and relevant to the management of HTN?

Output: clinical specialties and areas of expertise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the group identify that are important and relevant to the management of HTN?. ### Response: clinical specialties and areas of expertise.


Instruction: What was recruited from the Work Group members?

Output: clinical specialties and areas of expertise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was recruited from the Work Group members?. ### Response: clinical specialties and areas of expertise.


Instruction: What were the specialties and clinical areas of interest?

Output: internal medicine, family medicine, nephrology, cardiology, nutrition, nursing, and pharmacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the specialties and clinical areas of interest?. ### Response: internal medicine, family medicine, nephrology, cardiology, nutrition, nursing, and pharmacy.


Instruction: How was the guideline development process for the 2020 VA/DoD HTN CPG update?

Output: consisted of the following steps

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the guideline development process for the 2020 VA/DoD HTN CPG update?. ### Response: consisted of the following steps.


Instruction: What were the steps for the 2020 VA/DoD HTN CPG update?

Output: 1. Formulating and prioritizing KQs and defining critical outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the steps for the 2020 VA/DoD HTN CPG update?. ### Response: 1. Formulating and prioritizing KQs and defining critical outcomes.


Instruction: What was the name of the group that was convened for the patient focus group?

Output: Champions and Work Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the group that was convened for the patient focus group?. ### Response: Champions and Work Group.


Instruction: How many patients were enrolled in the trial of pass Surgery versus Angioplasty Using Sirolimus-ElutingStent in Patients with Left Main Coronary Artery Disease?

Output: 600

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were enrolled in the trial of pass Surgery versus Angioplasty Using Sirolimus-ElutingStent in Patients with Left Main Coronary Artery Disease?. ### Response: 600.


Instruction: What was the composite endpoint of death, MI, or stroke at 2 years?

Output: 4.4%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the composite endpoint of death, MI, or stroke at 2 years?. ### Response: 4.4%.


Instruction: How much of the patients treated with PCI were treated with CABG?

Output: 4.7%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the patients treated with PCI were treated with CABG?. ### Response: 4.7%.


Instruction: What was more often required in patients treated with PCI?

Output: Target-vessel revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was more often required in patients treated with PCI?. ### Response: Target-vessel revascularization.


Instruction: What percentage of patients with left main CAD had ischemia-driven target-vessel revascularization?

Output: 9.0% versus 4.2%).

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients with left main CAD had ischemia-driven target-vessel revascularization?. ### Response: 9.0% versus 4.2%)..


Instruction: What is higher after PCI than after CABG?

Output: repeat revascularization rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is higher after PCI than after CABG?. ### Response: repeat revascularization rates.


Instruction: What is required to provide definitive conclusions about the optimal treatment of left main CAD?

Output: RCTs with extendedfollow-up of /H113505 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is required to provide definitive conclusions about the optimal treatment of left main CAD?. ### Response: RCTs with extendedfollow-up of /H113505 years.


Instruction: How many cohort studies and 2 RCTs did a meta-analysis of?

Output: 8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many cohort studies and 2 RCTs did a meta-analysis of?. ### Response: 8.


Instruction: How many cohort studies were there?

Output: 8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many cohort studies were there?. ### Response: 8.


Instruction: How many deaths occurred with similar frequency in PCI- andCABG-treated patients at 1, 2, and 3 years of follow up?

Output: 329

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many deaths occurred with similar frequency in PCI- andCABG-treated patients at 1, 2, and 3 years of follow up?. ### Response: 329.


Instruction: What was performed more often in the PCI group at 1 year?

Output: Target-vessel revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was performed more often in the PCI group at 1 year?. ### Response: Target-vessel revascularization.


Instruction: What is the OR of PCI with CABG for left main CAD?

Output: mortality rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the OR of PCI with CABG for left main CAD?. ### Response: mortality rate.


Instruction: What has emerged as a possible alternative mode of revascularization?

Output: PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has emerged as a possible alternative mode of revascularization?. ### Response: PCI.


Instruction: What has emerged as a possible alternative mode of revascu-larization in carefully selected patients?

Output: PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has emerged as a possible alternative mode of revascu-larization in carefully selected patients?. ### Response: PCI.


Instruction: What is animportant determinant when considering PCI for unprotectedleft main CAD?

Output: Lesion location

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is animportant determinant when considering PCI for unprotectedleft main CAD?. ### Response: Lesion location.


Instruction: Stenting of the left main ostium or trunk is more straightforward than treating what?

Output: distal bifurcation or trifur-cation stenoses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Stenting of the left main ostium or trunk is more straightforward than treating what?. ### Response: distal bifurcation or trifur-cation stenoses.


Instruction: What type of stenoses requires a greater degree of operator experience and expertise?

Output: distal bifurcation or trifur-cation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of stenoses requires a greater degree of operator experience and expertise?. ### Response: distal bifurcation or trifur-cation.


Instruction: What is associated with higher restenosis rates when disease is confined to the ostium or trunk?

Output: PCI ofbifurcation disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with higher restenosis rates when disease is confined to the ostium or trunk?. ### Response: PCI ofbifurcation disease.


Instruction: Where does location exert a negligible influence on the success of PCI?

Output: CABG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where does location exert a negligible influence on the success of PCI?. ### Response: CABG.


Instruction: Where exerts a negligible influence on the success of CABG after PCI?

Output: lesion location

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where exerts a negligible influence on the success of CABG after PCI?. ### Response: lesion location.


Instruction: Patients with left main CAD and a SYNTAX score /H1135033 had a higher mortality rate with PCI than with what?

Output: CABG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with left main CAD and a SYNTAX score /H1135033 had a higher mortality rate with PCI than with what?. ### Response: CABG.


Instruction: What canphysicians estimate oper-ative risk for all CABG candidates by using?

Output: a standardinstrument

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What canphysicians estimate oper-ative risk for all CABG candidates by using?. ### Response: a standardinstrument.


Instruction: What is an example of a standard instrument used to calculate risk for CABG candidates?

Output: the risk calculator from the STS database

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a standard instrument used to calculate risk for CABG candidates?. ### Response: the risk calculator from the STS database.


Instruction: What are important considerations whenchoosing among revascularization strategies?

Output: Lesion location

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are important considerations whenchoosing among revascularization strategies?. ### Response: Lesion location.


Instruction: What has been recommended in cases where the choice of revasculariza-tion is not straightforward?

Output: Use of a Heart Team approach

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been recommended in cases where the choice of revasculariza-tion is not straightforward?. ### Response: Use of a Heart Team approach.


Instruction: What is also an important consider-ation in re-vascularization decisions?

Output: Lesion location

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is also an important consider-ation in re-vascularization decisions?. ### Response: Lesion location.


Instruction: The 2005 PCI guidelines466recommended what?

Output: routine angio-

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The 2005 PCI guidelines466recommended what?. ### Response: routine angio-.


Instruction: How many trials did a meta-analysis of the 2 trials af firms find additive bene fit across eachtimepoint from the addition of dapagli flozin?

Output: 45

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many trials did a meta-analysis of the 2 trials af firms find additive bene fit across eachtimepoint from the addition of dapagli flozin?. ### Response: 45.


Instruction: In the DAPA-HF trial, among the small number of patients receiving an ARNI, what was seen across each timepoint?

Output: additive bene

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the DAPA-HF trial, among the small number of patients receiving an ARNI, what was seen across each timepoint?. ### Response: additive bene.


Instruction: What is not necessary before adding SGLT2 inhibitors?

Output: Achieving target or maximally tolerated doses of otherdrugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not necessary before adding SGLT2 inhibitors?. ### Response: Achieving target or maximally tolerated doses of otherdrugs.


Instruction: What may need to be adjusted based onclose monitoring of weight and symptoms?

Output: loop diuretic dose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may need to be adjusted based onclose monitoring of weight and symptoms?. ### Response: loop diuretic dose.


Instruction: What are insulin-secretagogues?

Output: assulfonylureas

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are insulin-secretagogues?. ### Response: assulfonylureas.


Instruction: What may be helpful in order to minimize the risk of hypoglycemia inpatients with diabetes?

Output: coordinating care through the inclusion ofendocrinologists and primary care providers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be helpful in order to minimize the risk of hypoglycemia inpatients with diabetes?. ### Response: coordinating care through the inclusion ofendocrinologists and primary care providers.


Instruction: Why is HYD/ISDN-indicated therapy forHF often neglected?

Output: For several reasons

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is HYD/ISDN-indicated therapy forHF often neglected?. ### Response: For several reasons.


Instruction: How much relative reduction in mortality did this combination of drugs reduce?

Output: 43%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much relative reduction in mortality did this combination of drugs reduce?. ### Response: 43%.


Instruction: How much reduction in HF hospitali-zation did this drug combination have on health status?

Output: 33%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much reduction in HF hospitali-zation did this drug combination have on health status?. ### Response: 33%.


Instruction: Who should receive beta-blocker,ARNI/ACEI/ARB, and aldosterone antagonists once target or maximal tolerated doses?

Output: African-American patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should receive beta-blocker,ARNI/ACEI/ARB, and aldosterone antagonists once target or maximal tolerated doses?. ### Response: African-American patients.


Instruction: How many aldosterone antagonists are ach-ieved?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many aldosterone antagonists are ach-ieved?. ### Response: 3.


Instruction: What is avabradine especially impor-tant for in patients with NYHA class III to IVsymptoms?

Output: aldosterone antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is avabradine especially impor-tant for in patients with NYHA class III to IVsymptoms?. ### Response: aldosterone antagonists.


Instruction: In patients with heart rate remains $70beats/min on target or maximally tolerated doses of beta-blockers, what can be added?

Output: ivabradine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with heart rate remains $70beats/min on target or maximally tolerated doses of beta-blockers, what can be added?. ### Response: ivabradine.


Instruction: What can be added and titrated at 2weeks to lower the heart rate?

Output: ivabradine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be added and titrated at 2weeks to lower the heart rate?. ### Response: ivabradine.


Instruction: What are patients seen in clinicalpractice typically older?

Output: patients seen in clinicalpractice are typically older, may experience more sideeffects including hypotension, and are likely to have morecomorbidities that will limit titration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients seen in clinicalpractice typically older?. ### Response: patients seen in clinicalpractice are typically older, may experience more sideeffects including hypotension, and are likely to have morecomorbidities that will limit titration.


Instruction: What may experience more sideeffects including hypotension?

Output: patients seen in clinicalpractice are typically older

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may experience more sideeffects including hypotension?. ### Response: patients seen in clinicalpractice are typically older.


Instruction: How are datalacking?

Output: lacking

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are datalacking?. ### Response: lacking.


Instruction: Dose of multiple classes of GDMT are likely more effective in reducing risk than large doses of how many agents?

Output: 1 or 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Dose of multiple classes of GDMT are likely more effective in reducing risk than large doses of how many agents?. ### Response: 1 or 2.


Instruction: Abnormal renal function and/or hyperkalemia are common barriers to initiation and titration of what?

Output: GDMT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Abnormal renal function and/or hyperkalemia are common barriers to initiation and titration of what?. ### Response: GDMT.


Instruction: What are two newerpotassium binders now approved by the Food and DrugAdministration and may be co nsidered?

Output: patiromer and sodium zirconiumcyclosilicate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are two newerpotassium binders now approved by the Food and DrugAdministration and may be co nsidered?. ### Response: patiromer and sodium zirconiumcyclosilicate.


Instruction: What has not been shown to increaseGDMT use or have an impact on patientswithHFrEF?

Output: potassium binders

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has not been shown to increaseGDMT use or have an impact on patientswithHFrEF?. ### Response: potassium binders.


Instruction: What has been shown to increaseGDMT use or have an impact on outcomes in patients?

Output: below-target doses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been shown to increaseGDMT use or have an impact on outcomes in patients?. ### Response: below-target doses.


Instruction: What raises concerns in terms of cost/access and their contribution to polypharmacy?

Output: these agents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What raises concerns in terms of cost/access and their contribution to polypharmacy?. ### Response: these agents.


Instruction: What is JACC VOL. 77, NO. 6, 20212021 Update to 2017 ECDP for Optimization of Heart Failure Treatment?

Output: A trialexamining whether a strategy of potassium binding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is JACC VOL. 77, NO. 6, 20212021 Update to 2017 ECDP for Optimization of Heart Failure Treatment?. ### Response: A trialexamining whether a strategy of potassium binding.


Instruction: FEBRUARY 16, 2021:772 – 810788

Output: potassium binders (patiromer and sodium zirconiumcyclosilicate) are now approved by the Food and DrugAdministration and may be co nsidered; however, moredata are needed regarding use of such agents in patientswith HFrEF, as their use has not been shown to increaseGDMT use or have an impact on outcomes in patients.Additionally, these agents raise concerns in terms of cost/access and their contribution to polypharmacy. A trialexamining whether a strategy of potassium binding willpotentiate GDMT prescription and improve HFrEFMaddox et al . JACC VOL. 77, NO. 6, 20212021 Update to 2017 ECDP for Optimization of Heart Failure Treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: FEBRUARY 16, 2021:772 – 810788. ### Response: potassium binders (patiromer and sodium zirconiumcyclosilicate) are now approved by the Food and DrugAdministration and may be co nsidered; however, moredata are needed regarding use of such agents in patientswith HFrEF, as their use has not been shown to increaseGDMT use or have an impact on outcomes in patients.Additionally, these agents raise concerns in terms of cost/access and their contribution to polypharmacy. A trialexamining whether a strategy of potassium binding willpotentiate GDMT prescription and improve HFrEFMaddox et al . JACC VOL. 77, NO. 6, 20212021 Update to 2017 ECDP for Optimization of Heart Failure Treatment.


Instruction: How much albumin is excreted per 24 hours?

Output: 4300 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much albumin is excreted per 24 hours?. ### Response: 4300 mg.


Instruction: What is the office BP of a diabetic with diabetes mellitus?

Output: 4130 mm Hg systolic or480 mm Hg diastolic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the office BP of a diabetic with diabetes mellitus?. ### Response: 4130 mm Hg systolic or480 mm Hg diastolic.


Instruction: How many mm Hg diastolic are diabetics treated with?

Output: 480

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mm Hg diastolic are diabetics treated with?. ### Response: 480.


Instruction: What should be treated with BP-lowering drugs to maintain a BP that is consistently r140 mm Hg systolic?

Output: proteinuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be treated with BP-lowering drugs to maintain a BP that is consistently r140 mm Hg systolic?. ### Response: proteinuria.


Instruction: What should adults with diabetes and CKD ND have urine albumin excretion 430 mg per 24 hours?

Output: BP-lowering drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should adults with diabetes and CKD ND have urine albumin excretion 430 mg per 24 hours?. ### Response: BP-lowering drugs.


Instruction: What is the BP of an office whose office BP is consistently 4130 mm Hg systolic?

Output: 430 mg per 24 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the BP of an office whose office BP is consistently 4130 mm Hg systolic?. ### Response: 430 mg per 24 hours.


Instruction: What should be treated with BP-lowering drugs to maintain?

Output: proteinuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be treated with BP-lowering drugs to maintain?. ### Response: proteinuria.


Instruction: What is recommended in adults with diabetes and CKD ND with urine albumin excretion of 30 to 300 mg per 24 hours (or equivalent*)?

Output: an ARB or ACE-I

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended in adults with diabetes and CKD ND with urine albumin excretion of 30 to 300 mg per 24 hours (or equivalent*)?. ### Response: an ARB or ACE-I.


Instruction: What is another name for ARB or ACE-I?

Output: CKD ND

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for ARB or ACE-I?. ### Response: CKD ND.


Instruction: How much albumin is excreted per 24 hours in adults with diabetes and CKD ND?

Output: 4300 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much albumin is excreted per 24 hours in adults with diabetes and CKD ND?. ### Response: 4300 mg.


Instruction: What is the prot ein/creatinine ratio?

Output: o30 mg per 24 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the prot ein/creatinine ratio?. ### Response: o30 mg per 24 hours.


Instruction: What are the results of the reagent strip in Table 1?

Output: Approximate equivalents for albumin excretion rate per 24 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of the reagent strip in Table 1?. ### Response: Approximate equivalents for albumin excretion rate per 24 hours.


Instruction: What is the name of the chapter that describes the management of blood pressure in transplant recipients?

Output: Chapter 5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the chapter that describes the management of blood pressure in transplant recipients?. ### Response: Chapter 5.


Instruction: What is the BP of a kidney transplant recipient?

Output: 4130 mm Hg systolic or480 mm Hg diastolic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the BP of a kidney transplant recipient?. ### Response: 4130 mm Hg systolic or480 mm Hg diastolic.


Instruction: What is a BP-lowering agent for kidney transplant recipients?

Output: calcineurin inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a BP-lowering agent for kidney transplant recipients?. ### Response: calcineurin inhibitors.


Instruction: What is a co-morbid condition in children with CKD ND?

Output: diabetes mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a co-morbid condition in children with CKD ND?. ### Response: diabetes mellitus.


Instruction: When should BP-lowering treatment be started?

Output: when BP is consistently above the90thpercentile for age, sex, and height

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When should BP-lowering treatment be started?. ### Response: when BP is consistently above the90thpercentile for age, sex, and height.


Instruction: What is the recommended level for age, sex, and height?

Output: 90thpercentile

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommended level for age, sex, and height?. ### Response: 90thpercentile.


Instruction: What is the 90thpercentile for age, sex, and height?

Output: BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 90thpercentile for age, sex, and height?. ### Response: BP.


Instruction: In children with CKD ND, BP should be lowered to consistentlyachieve what?

Output: systolic and diastolic readings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In children with CKD ND, BP should be lowered to consistentlyachieve what?. ### Response: systolic and diastolic readings.


Instruction: What is a limitation of achieving these targets?

Output: signs or symptoms of hypotension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a limitation of achieving these targets?. ### Response: signs or symptoms of hypotension.


Instruction: What should be used in children with CKD ND in whom treatment with BP-lowering drugs isindicated?

Output: ARB or ACE-I

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be used in children with CKD ND in whom treatment with BP-lowering drugs isindicated?. ### Response: ARB or ACE-I.


Instruction: How do patients with CKD ND manage their blood pressure?

Output: urine albumin excretion4300 mg per 24 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do patients with CKD ND manage their blood pressure?. ### Response: urine albumin excretion4300 mg per 24 hours.


Instruction: What are some of the adverse events associated with BP treatment?

Output: electrolyte disorders, acute deterioration in kidney function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the adverse events associated with BP treatment?. ### Response: electrolyte disorders, acute deterioration in kidney function.


Instruction: What is a treatment for electrolyte disorders?

Output: BP-lowering drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a treatment for electrolyte disorders?. ### Response: BP-lowering drugs.


Instruction: What is an example of a drug side effect?

Output: orthostatic hypotension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a drug side effect?. ### Response: orthostatic hypotension.


Instruction: What is the name of a randomized trial of 100 mg of aspirin on alternate days versus placebo in 39 876 initially asymptomatic women 45 years of age?

Output: WHS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of a randomized trial of 100 mg of aspirin on alternate days versus placebo in 39 876 initially asymptomatic women 45 years of age?. ### Response: WHS.


Instruction: How long did the WHS follow up for a first major vascular event?

Output: 10 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the WHS follow up for a first major vascular event?. ### Response: 10 years.


Instruction: What is a nonfatal MI, non-fatal stroke or cardiovascular death?

Output: first major vascular event

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a nonfatal MI, non-fatal stroke or cardiovascular death?. ### Response: first major vascular event.


Instruction: What is another term for a nonfatal MI, non-fatal stroke, or cardiovascular death?

Output: first major vascular event

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for a nonfatal MI, non-fatal stroke, or cardiovascular death?. ### Response: first major vascular event.


Instruction: What was the RR of the combined primary end point among women?

Output: 0.91

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the RR of the combined primary end point among women?. ### Response: 0.91.


Instruction: How much reduction in the risk of stroke did the study find?

Output: 17%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much reduction in the risk of stroke did the study find?. ### Response: 17%.


Instruction: What was the RR of IS?

Output: 0.76

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the RR of IS?. ### Response: 0.76.


Instruction: What was a nonsignificant increase in the risk of hemor -rhagic stroke?

Output: RR, 1.24

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a nonsignificant increase in the risk of hemor -rhagic stroke?. ### Response: RR, 1.24.


Instruction: The overall stroke rates were what?

Output: 0.11% per year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The overall stroke rates were what?. ### Response: 0.11% per year.


Instruction: What was the overall stroke rate in aspirin-treated women?

Output: 0.11% per year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the overall stroke rate in aspirin-treated women?. ### Response: 0.11% per year.


Instruction: What is the RR of placebo-treated females?

Output: 0.02% per year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the RR of placebo-treated females?. ### Response: 0.02% per year.


Instruction: Which group had the most frequent gastrointestinal hemorrhage requiring transfusion?

Output: aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which group had the most frequent gastrointestinal hemorrhage requiring transfusion?. ### Response: aspirin.


Instruction: What was the most consistent benefit for aspirin in women  65 years of age at study entry?

Output: the risk of major cardiovascular events was reduced by 26%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the most consistent benefit for aspirin in women  65 years of age at study entry?. ### Response: the risk of major cardiovascular events was reduced by 26%.


Instruction: How much was the risk of major cardiovascular events reduced among women in the study?

Output: 26%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much was the risk of major cardiovascular events reduced among women in the study?. ### Response: 26%.


Instruction: What was the RR of women at study entry?

Output: Total Patients Enrolled

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the RR of women at study entry?. ### Response: Total Patients Enrolled.


Instruction: In the study, what percentage of women had a lower risk of cardiovascular events?

Output: 26%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the study, what percentage of women had a lower risk of cardiovascular events?. ### Response: 26%.


Instruction: What is the name of the Asymptomatic Carotid Atherosclerosis Study?

Output: ACAS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Asymptomatic Carotid Atherosclerosis Study?. ### Response: ACAS.


Instruction: What is CREST?

Output: Carotid Revascularization Endarterectomy Versus Stenting Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CREST?. ### Response: Carotid Revascularization Endarterectomy Versus Stenting Trial.


Instruction: WHAT is NASCET?

Output: North American Symptomatic Carotid Endarterectomy Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: WHAT is NASCET?. ### Response: North American Symptomatic Carotid Endarterectomy Trial.


Instruction: What is the name of the North American Symptomatic Carotid Endarterectomy Trial?

Output: NASCET

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the North American Symptomatic Carotid Endarterectomy Trial?. ### Response: NASCET.


Instruction: What is SPACE?

Output: Stent-Protected Angioplasty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SPACE?. ### Response: Stent-Protected Angioplasty.


Instruction: What is ACE?

Output: ASA [acetylsalicylic acid]

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ACE?. ### Response: ASA [acetylsalicylic acid].


Instruction: What does ASA stand for?

Output: acetylsalicylic acid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ASA stand for?. ### Response: acetylsalicylic acid.


Instruction: CAPRIE stands for what?

Output: Clopidogrel Versus Aspirin in Patients at Risk of Ischaemic Events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: CAPRIE stands for what?. ### Response: Clopidogrel Versus Aspirin in Patients at Risk of Ischaemic Events.


Instruction: What is ESPRIT?

Output: European/Australasian Stroke Prevention in Reversible Ischaemia Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ESPRIT?. ### Response: European/Australasian Stroke Prevention in Reversible Ischaemia Trial.


Instruction: What is MATCH?

Output: Management of Atherosclerosis With Clopidogrel in High-Risk Patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is MATCH?. ### Response: Management of Atherosclerosis With Clopidogrel in High-Risk Patients.


Instruction: PRoFESS stands for?

Output: Prevention Regimen for Effectively Avoiding Second Strokes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: PRoFESS stands for?. ### Response: Prevention Regimen for Effectively Avoiding Second Strokes.


Instruction: SPS stands for what?

Output: Secondary Prevention of Small Subcortical Strokes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: SPS stands for what?. ### Response: Secondary Prevention of Small Subcortical Strokes.


Instruction: What is the primary imaging modality to assess the location and quantify the severity of prosthetic valve regurgitation?

Output: Echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary imaging modality to assess the location and quantify the severity of prosthetic valve regurgitation?. ### Response: Echocardiography.


Instruction: What is often required both TTE and TEE?

Output: Echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is often required both TTE and TEE?. ### Response: Echocardiography.


Instruction: What two approaches do prosthetic valve regurgitation often require?

Output: TTE and TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What two approaches do prosthetic valve regurgitation often require?. ### Response: TTE and TEE.


Instruction: What is better suited to identify the cause and location?

Output: TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is better suited to identify the cause and location?. ### Response: TEE.


Instruction: Why is TEE essential for prosthetic mitral valve?

Output: acoustic shadow-ing on TTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is TEE essential for prosthetic mitral valve?. ### Response: acoustic shadow-ing on TTE.


Instruction: TTE provides supe-rior assessment of what?

Output: transvalvular gradients, chamber sizes, and function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: TTE provides supe-rior assessment of what?. ### Response: transvalvular gradients, chamber sizes, and function.


Instruction: What can affect detection of paravalvular leak by TTE or TEE?

Output: acous-tic shadowing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can affect detection of paravalvular leak by TTE or TEE?. ### Response: acous-tic shadowing.


Instruction: What is TTE suboptimal to assess?

Output: posterior paravalvular leak

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is TTE suboptimal to assess?. ### Response: posterior paravalvular leak.


Instruction: TEE subop-timal to assess what?

Output: anterior defects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: TEE subop-timal to assess what?. ### Response: anterior defects.


Instruction: What does VARC stand for?

Output: Valve Academic Research Consortium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does VARC stand for?. ### Response: Valve Academic Research Consortium.


Instruction: What has been suggested for assessment of paravalvular leak severity and constructed a 5-class grading scheme?

Output: The Valve Academic Research Consortium (VARC) has suggested an approach

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been suggested for assessment of paravalvular leak severity and constructed a 5-class grading scheme?. ### Response: The Valve Academic Research Consortium (VARC) has suggested an approach.


Instruction: How does 3D echocardiography play a significant role in determining the precise location and size of the paravalve leak in patients undergoing interven-tion?

Output: 72

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does 3D echocardiography play a significant role in determining the precise location and size of the paravalve leak in patients undergoing interven-tion?. ### Response: 72.


Instruction: What type of leak occurs in patients undergoing interven-tion?

Output: paravalvular leak

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of leak occurs in patients undergoing interven-tion?. ### Response: paravalvular leak.


Instruction: For a successful transcatheter paravalvular leak closure, what must be assessed?

Output: precise location of the defect(s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For a successful transcatheter paravalvular leak closure, what must be assessed?. ### Response: precise location of the defect(s.


Instruction: What should be assessed in relation to the sewing ring and prosthetic valve occluders?

Output: orientation of the defect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be assessed in relation to the sewing ring and prosthetic valve occluders?. ### Response: orientation of the defect.


Instruction: What allows optimal visualization of the defects and direct guidance for catheter movement and positioning of implanted device(s) during the transcatheter closure procedure?

Output: Real-time 3D TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What allows optimal visualization of the defects and direct guidance for catheter movement and positioning of implanted device(s) during the transcatheter closure procedure?. ### Response: Real-time 3D TEE.


Instruction: What allows assessment of residual regurgitation after device placement?

Output: 3D TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What allows assessment of residual regurgitation after device placement?. ### Response: 3D TEE.


Instruction: What are some limitations of 3D TEE?

Output: artifacts of ultrasound imaging (eg, dropout, acoustic shadowing, rever -beration artifacts) and reduced temporal and spatial resolution

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some limitations of 3D TEE?. ### Response: artifacts of ultrasound imaging (eg, dropout, acoustic shadowing, rever -beration artifacts) and reduced temporal and spatial resolution.


Instruction: Transcatheter closure using intracardiac echocardiography guidance is possible?

Output: 8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Transcatheter closure using intracardiac echocardiography guidance is possible?. ### Response: 8.


Instruction: What is ap-propriate in asymptomatic patients or when the cause of regurgitation is valve thrombosis?

Output: Medical therapy for prosthetic valve regurgitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ap-propriate in asymptomatic patients or when the cause of regurgitation is valve thrombosis?. ### Response: Medical therapy for prosthetic valve regurgitation.


Instruction: How long do some patients tolerate asymp-tomatic prosthetic valve regurgitation?

Output: many years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long do some patients tolerate asymp-tomatic prosthetic valve regurgitation?. ### Response: many years.


Instruction: What may patients develop rapid progression of the severity of bioprosthetic valve regurgitation because of?

Output: leaflet degeneration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may patients develop rapid progression of the severity of bioprosthetic valve regurgitation because of?. ### Response: leaflet degeneration.


Instruction: What is hemolytic ane-mia attributable to?

Output: paravalvular regurgitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hemolytic ane-mia attributable to?. ### Response: paravalvular regurgitation.


Instruction: Who is the Director of the Evidence Review Team?

Output: Jonathan C. Craig

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Director of the Evidence Review Team?. ### Response: Jonathan C. Craig.


Instruction: What is the title of the Associate Project Director?

Output: Assistant Project Director

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of the Associate Project Director?. ### Response: Assistant Project Director.


Instruction: Who is a co-director of the Evidence Review Team?

Output: Suetonia C. Palmer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a co-director of the Evidence Review Team?. ### Response: Suetonia C. Palmer.


Instruction: Who is the Managing Editor of Cochrane Kidney and Transplant?

Output: Gail Y. Higgins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Managing Editor of Cochrane Kidney and Transplant?. ### Response: Gail Y. Higgins.


Instruction: What is the MSc in Evidence-based Health Care?

Output: Research Associate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the MSc in Evidence-based Health Care?. ### Response: Research Associate.


Instruction: Who is a Research Associate of the guideline?

Output: Nicole Evangelidis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a Research Associate of the guideline?. ### Response: Nicole Evangelidis.


Instruction: What are the names of the authors who have updated their reviews?

Output: Elisabeth Hodson, Emma McMahon, Patrizia Natale,Narelle Willis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the authors who have updated their reviews?. ### Response: Elisabeth Hodson, Emma McMahon, Patrizia Natale,Narelle Willis.


Instruction: Who has updated their reviews for this guideline?

Output: Elisabeth Hodson, Emma McMahon, Patrizia Natale,Narelle Willis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who has updated their reviews for this guideline?. ### Response: Elisabeth Hodson, Emma McMahon, Patrizia Natale,Narelle Willis.


Instruction: What is the name of the person who has updated his reviews?

Output: Elisabeth Hodson, Emma McMahon, Patrizia Natale,Narelle Willis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the person who has updated his reviews?. ### Response: Elisabeth Hodson, Emma McMahon, Patrizia Natale,Narelle Willis.


Instruction: Who is a member of the Work Group?

Output: MAGICAPP LIAISON

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a member of the Work Group?. ### Response: MAGICAPP LIAISON.


Instruction: What is NICE 2018?

Output: Chronic Heart Failure  © NICE 2018. All rights reserved

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE 2018?. ### Response: Chronic Heart Failure  © NICE 2018. All rights reserved.


Instruction: What is the study design and sample size?

Output: Finding  Quality assessment  Number of studies contributing to the finding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the study design and sample size?. ### Response: Finding  Quality assessment  Number of studies contributing to the finding.


Instruction: How many studies contribute to the finding?

Output: Number

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies contribute to the finding?. ### Response: Number.


Instruction: What is the overall rating of confidence and FG with professional carers?

Output: Overall assessment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the overall rating of confidence and FG with professional carers?. ### Response: Overall assessment.


Instruction: What type of study involving pt and HCPs?

Output: Ethnographic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of study involving pt and HCPs?. ### Response: Ethnographic.


Instruction: Understanding of diagnosis and diagnosis of heart failure 2a?

Output: 98, 26, 53, 117, 133, 141, 207, 231, 328

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Understanding of diagnosis and diagnosis of heart failure 2a?. ### Response: 98, 26, 53, 117, 133, 141, 207, 231, 328.


Instruction: Understanding heart failure 2a. Understanding of diagnosis 98, 26, 53, 117, 133, 141, 207, 231, 328 Semi -structured interviews with pt + carers and focus groups with HCPs

Output: 978 -1-4731 -3093 -7 406

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Understanding heart failure 2a. Understanding of diagnosis 98, 26, 53, 117, 133, 141, 207, 231, 328 Semi -structured interviews with pt + carers and focus groups with HCPs. ### Response: 978 -1-4731 -3093 -7 406.


Instruction: Interviews with pt + carer and inter views or FG with HCPs Open -ended narrative interviews with what?

Output: pt

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Interviews with pt + carer and inter views or FG with HCPs Open -ended narrative interviews with what?. ### Response: pt.


Instruction: Secondary analysis of interview transcripts of what? Interviews following bereavement interviews with informal carers and what with professional carers Semi -structured interviews with who?

Output: pt

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Secondary analysis of interview transcripts of what? Interviews following bereavement interviews with informal carers and what with professional carers Semi -structured interviews with who?. ### Response: pt.


Instruction: FG with professional carers Semi -structured interviews with pt, their carers and what else?

Output: HCPs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: FG with professional carers Semi -structured interviews with pt, their carers and what else?. ### Response: HCPs.


Instruction: Ethnographic study involving Pt and HCPs What is generally poor?

Output: Semi -structured interviews with Although there is variability in patients’ understanding of their diagnosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Ethnographic study involving Pt and HCPs What is generally poor?. ### Response: Semi -structured interviews with Although there is variability in patients’ understanding of their diagnosis.


Instruction: What is variability in patients’ understanding of their diagnosis?

Output: it is generally poor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is variability in patients’ understanding of their diagnosis?. ### Response: it is generally poor.


Instruction: What are some concerns about methodological limitations?

Output: Serious concerns

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some concerns about methodological limitations?. ### Response: Serious concerns.


Instruction: What is LOW Coherence Minor concerns about?

Output: coherence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is LOW Coherence Minor concerns about?. ### Response: coherence.


Instruction: What did the composite outcome of CV mortality and HF admission suggest?

Output: a clinically important reduction in events with ARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the composite outcome of CV mortality and HF admission suggest?. ### Response: a clinically important reduction in events with ARBs.


Instruction: What was the outcome'morbid events' which included hospitalisations and death?

Output: n=2917

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome'morbid events' which included hospitalisations and death?. ### Response: n=2917.


Instruction: When was there no clinically important effect of ARBs on renal function?

Output: n=2179

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was there no clinically important effect of ARBs on renal function?. ### Response: n=2179.


Instruction: How many studies reported no clinically important effect of ARBs on eGFR?

Output: n=2179

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies reported no clinically important effect of ARBs on eGFR?. ### Response: n=2179.