Instruction: How long was the follow-up of the CASE study?

Output: Ten-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the follow-up of the CASE study?. ### Response: Ten-year.


Instruction: What is the name of the randomized study that studied myocardial infarction?

Output: Coronary ArterySurgery Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized study that studied myocardial infarction?. ### Response: Coronary ArterySurgery Study.


Instruction: When was the Circulation of the Coronary ArterySurgery Study conducted?

Output: 1990

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circulation of the Coronary ArterySurgery Study conducted?. ### Response: 1990.


Instruction: What was the result of Coronary bypass surgery inchronic stable angina?

Output: Eleven-year survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the result of Coronary bypass surgery inchronic stable angina?. ### Response: Eleven-year survival.


Instruction: How was the progression of therapy for coronary artery disease?

Output: Continuing evolution

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the progression of therapy for coronary artery disease?. ### Response: Continuing evolution.


Instruction: What is a surrogate marker for the diagnosis of coronary narrowing?

Output: acoronary artery jeopardy score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a surrogate marker for the diagnosis of coronary narrowing?. ### Response: acoronary artery jeopardy score.


Instruction: What are the initial results from the era ofcoronary angioplasty?

Output: Eleven-year survival in the Veterans Administration randomized trialof coronary bypass surgery for stable angina. The Veterans Adminis-tration Coronary Artery Bypass Surgery Cooperative Study Group.N Engl J Med. 1984;311:1333–9.374. Ringqvist I, Fisher LD, Mock M, et al. Prognostic value of angio-graphic indices of coronary artery disease from the Coronary ArterySurgery Study (CASS). J Clin Invest. 1983;71:1854–66.375. Alderman EL, Bourassa MG, Cohen LS, et al. Ten-year follow-up ofsurvival and myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the initial results from the era ofcoronary angioplasty?. ### Response: Eleven-year survival in the Veterans Administration randomized trialof coronary bypass surgery for stable angina. The Veterans Adminis-tration Coronary Artery Bypass Surgery Cooperative Study Group.N Engl J Med. 1984;311:1333–9.374. Ringqvist I, Fisher LD, Mock M, et al. Prognostic value of angio-graphic indices of coronary artery disease from the Coronary ArterySurgery Study (CASS). J Clin Invest. 1983;71:1854–66.375. Alderman EL, Bourassa MG, Cohen LS, et al. Ten-year follow-up ofsurvival and myocardial infarction.


Instruction: What is a surrogate marker for the extent of coronaryatherosclerosis?

Output: Angiographic severityof coronary narrowing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a surrogate marker for the extent of coronaryatherosclerosis?. ### Response: Angiographic severityof coronary narrowing.


Instruction: What is the influence of aortocoronary bypass surgery on survival?

Output: Left main coronary arterystenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the influence of aortocoronary bypass surgery on survival?. ### Response: Left main coronary arterystenosis.


Instruction: What is the prognostic spectrum of leftmain stenosis?

Output: 57:947–52.383

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the prognostic spectrum of leftmain stenosis?. ### Response: 57:947–52.383.


Instruction: What is Davis KB, Sopko G, et al. comparing in patients with left main coronaryarterydisease?

Output: surgical andmedical group survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Davis KB, Sopko G, et al. comparing in patients with left main coronaryarterydisease?. ### Response: surgical andmedical group survival.


Instruction: What is angiographic determination of left main coronary artery stenosis?

Output: severity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is angiographic determination of left main coronary artery stenosis?. ### Response: severity.


Instruction: How many patients were examined in 1981?

Output: 28

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were examined in 1981?. ### Response: 28.


Instruction: What is our preoccupation with?

Output: coronary luminology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is our preoccupation with?. ### Response: coronary luminology.


Instruction: What is our preoccupation with coronary luminology?

Output: The dissociation between clinical and angiographic findings in ische-mic heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is our preoccupation with coronary luminology?. ### Response: The dissociation between clinical and angiographic findings in ische-mic heart disease.


Instruction: What is the dissociation between clinical and angiographic findings in ischemic heart disease?

Output: Our preoccupation with coronary luminology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the dissociation between clinical and angiographic findings in ischemic heart disease?. ### Response: Our preoccupation with coronary luminology.


Instruction: What is the name of the main stem of the left coronary artery?

Output: stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the main stem of the left coronary artery?. ### Response: stenosis.


Instruction: What is a comparison of exercise performance in left main and three-vessel coronary disease?

Output: Gibbons

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a comparison of exercise performance in left main and three-vessel coronary disease?. ### Response: Gibbons.


Instruction: What is left main coronary artery stenosis?

Output: angiographic determination

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is left main coronary artery stenosis?. ### Response: angiographic determination.


Instruction: How can patients with left main disease be identified?

Output: Exercise testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can patients with left main disease be identified?. ### Response: Exercise testing.


Instruction: How much was the risk of reexploration for bleeding increased in patients exposed to clopidogrel within 5 days of surgery?

Output: 3-fold

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much was the risk of reexploration for bleeding increased in patients exposed to clopidogrel within 5 days of surgery?. ### Response: 3-fold.


Instruction: How many patients required transfusions?

Output: half

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients required transfusions?. ### Response: half.


Instruction: What drug should be withheld in patients taking elective CABG?

Output: clopidogrel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug should be withheld in patients taking elective CABG?. ### Response: clopidogrel.


Instruction: When should the drug be withheld?

Output: In patients taking clopidogrel inwhom elective CABG is planned

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When should the drug be withheld?. ### Response: In patients taking clopidogrel inwhom elective CABG is planned.


Instruction: Who published the ACCF/AHA CABG Guideline e693?

Output: Hillis et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the ACCF/AHA CABG Guideline e693?. ### Response: Hillis et al.


Instruction: What is the effect ofcarvedilol on morbidity and mortality in patients withchronic heart failure?

Output: improvements in leftventricular function and survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect ofcarvedilol on morbidity and mortality in patients withchronic heart failure?. ### Response: improvements in leftventricular function and survival.


Instruction: What does Car-vedillol produce dose-related improvements in?

Output: leftventricular function and survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Car-vedillol produce dose-related improvements in?. ### Response: leftventricular function and survival.


Instruction: Who are MOCHA Investigators?

Output: Boehringer Ingelheim Pharmaceuticals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who are MOCHA Investigators?. ### Response: Boehringer Ingelheim Pharmaceuticals.


Instruction: What does Empagli flozin meet in Phase III heart failuretrial?

Output: primary endpoint

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Empagli flozin meet in Phase III heart failuretrial?. ### Response: primary endpoint.


Instruction: What is the primary endpoint of the Phase III trial?

Output: Empagli

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary endpoint of the Phase III trial?. ### Response: Empagli.


Instruction: What did Claggett BL, et al. do in patients with HFrEF treated withsacubitril/valsartan: the DAPA-HF Trial?

Output: Effect ofdapagli ﬂozin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Claggett BL, et al. do in patients with HFrEF treated withsacubitril/valsartan: the DAPA-HF Trial?. ### Response: Effect ofdapagli ﬂozin.


Instruction: What did Honigberg MC, Vardeny O, Vaduganathan M say about the use of sodium-glucoseco-transporter inhibitors in heart failure?

Output: Practical considerations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Honigberg MC, Vardeny O, Vaduganathan M say about the use of sodium-glucoseco-transporter inhibitors in heart failure?. ### Response: Practical considerations.


Instruction: What is hydralazine used for in blacks with heart failure?

Output: Combination

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hydralazine used for in blacks with heart failure?. ### Response: Combination.


Instruction: What is the N Engl J Med. 2004:351:2049–57.48.

Output: Combination ofisosorbide dinitrate and hydralazine in blacks withheart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the N Engl J Med. 2004:351:2049–57.48.. ### Response: Combination ofisosorbide dinitrate and hydralazine in blacks withheart failure.


Instruction: What is the DOSE-AHF trial?

Output: Diuretic Optimization Strategies Evaluation in AcuteHeart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the DOSE-AHF trial?. ### Response: Diuretic Optimization Strategies Evaluation in AcuteHeart Failure.


Instruction: What are the results of DOSE - AHF?

Output: In-ﬂuence of diuretic dose and route of administrationon loop diuretic ef ﬁciency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of DOSE - AHF?. ### Response: In-ﬂuence of diuretic dose and route of administrationon loop diuretic ef ﬁciency.


Instruction: When did Faera LE, MacLean TE, Fischer CM, et al. do?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Faera LE, MacLean TE, Fischer CM, et al. do?. ### Response: 2014.


Instruction: What is the name of the organization that provides virtual visits to patients with heart failure?

Output: Heart Failure Societyof America

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that provides virtual visits to patients with heart failure?. ### Response: Heart Failure Societyof America.


Instruction: What are the names of the organizations that provide virtual visits for care of heart failure patients?

Output: Heart Failure Societyof America

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the organizations that provide virtual visits for care of heart failure patients?. ### Response: Heart Failure Societyof America.


Instruction: What is a newly approved diagnosis for cardiacrehabilitation?

Output: Heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a newly approved diagnosis for cardiacrehabilitation?. ### Response: Heart failure.


Instruction: What is the J Am CollCardiol. 2015:65:2652–9.52.

Output: Heart failure as a newly approved diagnosis for cardiacrehabilitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the J Am CollCardiol. 2015:65:2652–9.52.. ### Response: Heart failure as a newly approved diagnosis for cardiacrehabilitation.


Instruction: What are the considerations for during the COVID-19 pandemic?

Output: heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the considerations for during the COVID-19 pandemic?. ### Response: heart failure.


Instruction: What is the name of a mnemonic to aid referral in advanced heart failure?

Output: Baumwol J. “I Need Help

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of a mnemonic to aid referral in advanced heart failure?. ### Response: Baumwol J. “I Need Help.


Instruction: What is a term for "I Need Help"?

Output: —a mnemonic to aidtimely referral in advanced heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a term for "I Need Help"?. ### Response: —a mnemonic to aidtimely referral in advanced heart failure.


Instruction: When did the J Heart LungTransplant publish?

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the J Heart LungTransplant publish?. ### Response: 2017.


Instruction: What is the name of the pharmacological treatment for heart failure in pa-tients with recovered dilated cardiomyopathy?

Output: TRED-HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the pharmacological treatment for heart failure in pa-tients with recovered dilated cardiomyopathy?. ### Response: TRED-HF.


Instruction: When did the Lancet publish the results of the TRED-HF trial?

Output: 2019

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Lancet publish the results of the TRED-HF trial?. ### Response: 2019.


Instruction: Who is the JACC Scienti fic Expert Panel?

Output: Wilcox JE, Fang JC, Margulies KB, et al. Heartfailure with recovered left ventricular ejection fraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the JACC Scienti fic Expert Panel?. ### Response: Wilcox JE, Fang JC, Margulies KB, et al. Heartfailure with recovered left ventricular ejection fraction.


Instruction: What is JACC Scienti fic Expert Panel?

Output: Heartfailure with recovered left ventricular ejection fraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is JACC Scienti fic Expert Panel?. ### Response: Heartfailure with recovered left ventricular ejection fraction.


Instruction: What is the ventricular ejection fraction?

Output: left

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ventricular ejection fraction?. ### Response: left.


Instruction: What was the name of the trial that randomized 10,732 patients with STEMI toaspiration thrombectomy before primary PCI or primaryPCI only?

Output: The TOTAL (Trial of R outine Aspiration Throm-bectomy With PCI Versus PCI Alone in Patients WithSTEMI)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the trial that randomized 10,732 patients with STEMI toaspiration thrombectomy before primary PCI or primaryPCI only?. ### Response: The TOTAL (Trial of R outine Aspiration Throm-bectomy With PCI Versus PCI Alone in Patients WithSTEMI).


Instruction: What was performed in 7.1%of the primary PC I –only group?

Output: Bailout thrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was performed in 7.1%of the primary PC I –only group?. ### Response: Bailout thrombectomy.


Instruction: How many patients were randomized to the TOTAL trial?

Output: 10,732

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were randomized to the TOTAL trial?. ### Response: 10,732.


Instruction: What was the rate of cross-over from aspiration thrombectomy before primary PCI toprimary PCI only?

Output: 4.6%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the rate of cross-over from aspiration thrombectomy before primary PCI toprimary PCI only?. ### Response: 4.6%..


Instruction: What is the primary endpoint of cardiova scular death, recurrent MI,cardiogenic shock, or New York Heart Association class IVheart failure at 180 days?

Output: stent thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary endpoint of cardiova scular death, recurrent MI,cardiogenic shock, or New York Heart Association class IVheart failure at 180 days?. ### Response: stent thrombosis.


Instruction: How long did New York Heart Association class IVheart failure last?

Output: 180 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did New York Heart Association class IVheart failure last?. ### Response: 180 days.


Instruction: What was the primary endpoint of the study?

Output: stent thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary endpoint of the study?. ### Response: stent thrombosis.


Instruction: How many trials were included in an updated meta-analysis?

Output: 17

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many trials were included in an updated meta-analysis?. ### Response: 17.


Instruction: What was found to be no signi ficant reduction in death, reinfarction, orstent thrombosis?

Output: routine aspiration thrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was found to be no signi ficant reduction in death, reinfarction, orstent thrombosis?. ### Response: routine aspiration thrombectomy.


Instruction: What is a signi ficant reduction in death, reinfarction, orstent thrombosis with routine aspiration thrombectomy?

Output: major adverse cardiac events, stent thrombosis, and death(38–42). However, subgroup analyses from the TASTE andTOTAL trials did not suggest relative bene ﬁtf r o ma s p i r a -tion thrombectomy before primary PCI in patients withhigher thrombus burden or in pa tients with initial Throm-bolysis in Myocardial Infarction (TIMI) ﬂow grade 0 –1o rl e f tanterior descending artery/anterior infarction (34,35) .O nt h eb a s i so ft h er e s u l t so ft h e s es t u d i e s ,t h ep r i o rClass IIa recommendation for aspiration thrombectomyhas been changed. Routine aspiration thrombectomybefore primary PCI is now not recommended

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a signi ficant reduction in death, reinfarction, orstent thrombosis with routine aspiration thrombectomy?. ### Response: major adverse cardiac events, stent thrombosis, and death(38–42). However, subgroup analyses from the TASTE andTOTAL trials did not suggest relative bene ﬁtf r o ma s p i r a -tion thrombectomy before primary PCI in patients withhigher thrombus burden or in pa tients with initial Throm-bolysis in Myocardial Infarction (TIMI) ﬂow grade 0 –1o rl e f tanterior descending artery/anterior infarction (34,35) .O nt h eb a s i so ft h er e s u l t so ft h e s es t u d i e s ,t h ep r i o rClass IIa recommendation for aspiration thrombectomyhas been changed. Routine aspiration thrombectomybefore primary PCI is now not recommended.


Instruction: What has m a l lb u t increased in the risk of stroke?

Output: Aspiration thrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has m a l lb u t increased in the risk of stroke?. ### Response: Aspiration thrombectomy.


Instruction: How many previous studies have found that higherthrombus burden in patients?

Output: 35

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many previous studies have found that higherthrombus burden in patients?. ### Response: 35.


Instruction: How many previous studies have found that higherthrombus burden in patients with STEMI is independentlyassociated with higher risks of distal embolization?

Output: Several

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many previous studies have found that higherthrombus burden in patients with STEMI is independentlyassociated with higher risks of distal embolization?. ### Response: Several.


Instruction: What did subgroup analyses from the TASTE and TOTAL trials not suggest?

Output: relative bene

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did subgroup analyses from the TASTE and TOTAL trials not suggest?. ### Response: relative bene.


Instruction: What did not suggest relative bene fitf r o ma s p i ra tion thrombectomy before primary PCI?

Output: subgroup analyses from the TASTE andTOTAL trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did not suggest relative bene fitf r o ma s p i ra tion thrombectomy before primary PCI?. ### Response: subgroup analyses from the TASTE andTOTAL trials.


Instruction: What did trials not suggest in patients with higher thrombi burden or in pa tients with initial Throm-bolysis in Myocardial Infarction?

Output: relative bene ﬁtf r o ma s p i r a -tion thrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did trials not suggest in patients with higher thrombi burden or in pa tients with initial Throm-bolysis in Myocardial Infarction?. ### Response: relative bene ﬁtf r o ma s p i r a -tion thrombectomy.


Instruction: What is a class IIa recommendation for aspiration thrombectomy?

Output: Class IIb

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a class IIa recommendation for aspiration thrombectomy?. ### Response: Class IIb.


Instruction: What has been changed?

Output: Class IIa recommendation for aspiration thrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been changed?. ### Response: Class IIa recommendation for aspiration thrombectomy.


Instruction: What is no longer recommended before primary PCI?

Output: Routine aspiration thrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is no longer recommended before primary PCI?. ### Response: Routine aspiration thrombectomy.


Instruction: Forpatients undergoingprimary PCI (29-32), what is not well established?

Output: The usefulness ofselective andbailout aspirationthrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Forpatients undergoingprimary PCI (29-32), what is not well established?. ### Response: The usefulness ofselective andbailout aspirationthrombectomy.


Instruction: What does PCI indicate?

Output: percutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does PCI indicate?. ### Response: percutaneous coronary intervention.


Instruction: How is Routine aspirationthrombectomy before PCI?

Output: notuseful

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is Routine aspirationthrombectomy before PCI?. ### Response: notuseful.


Instruction: What is a new recommendation added forroutine aspirationthrombectomybefore PCI?

Output: “Class III: NoBeneﬁt

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a new recommendation added forroutine aspirationthrombectomybefore PCI?. ### Response: “Class III: NoBeneﬁt.


Instruction: What indicates percutaneous coronary intervention?

Output: PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates percutaneous coronary intervention?. ### Response: PCI.


Instruction: How many patients with ischaemic and non-ischaemic dilated car -diomyopathy were analysed?

Output: 1256

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with ischaemic and non-ischaemic dilated car -diomyopathy were analysed?. ### Response: 1256.


Instruction: What is the name of the study that examined 1256 patients?

Output: Heart

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined 1256 patients?. ### Response: Heart.


Instruction: What year did Cardiol. 2007:49:2191–201?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Cardiol. 2007:49:2191–201?. ### Response: 2007.


Instruction: What is the name of the study that impacted late survival in patients with moderate ischemic mitral regurgitation?

Output: Randomized Ischemic Mitral Evalu-ation (RIME) trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that impacted late survival in patients with moderate ischemic mitral regurgitation?. ### Response: Randomized Ischemic Mitral Evalu-ation (RIME) trial.


Instruction: In what year did Ann Thorac Surg. 2002:74:1468–75?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did Ann Thorac Surg. 2002:74:1468–75?. ### Response: 2011.


Instruction: What does combined mitral valve surgery improve in patients with ischemic mitral regurgitation?

Output: survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does combined mitral valve surgery improve in patients with ischemic mitral regurgitation?. ### Response: survival.


Instruction: How many patients were included in the meta-analysis of 2479 patients?

Output: 30

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were included in the meta-analysis of 2479 patients?. ### Response: 30.


Instruction: What is the effect of pathophysiology on the surgical treatment of ischemia mitral recurrence?

Output: operative and late risks of repair versus replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of pathophysiology on the surgical treatment of ischemia mitral recurrence?. ### Response: operative and late risks of repair versus replacement.


Instruction: In what year was the J Cardiovasc Med published?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was the J Cardiovasc Med published?. ### Response: 2009.


Instruction: What is the effect of pathophysiology on the surgical treatment of ischemic mitral regurgitation?

Output: operative and late risks of repair versus replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of pathophysiology on the surgical treatment of ischemic mitral regurgitation?. ### Response: operative and late risks of repair versus replacement.


Instruction: What are the operative and late risks of repair versus replacement?

Output: The effect of pathophysiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the operative and late risks of repair versus replacement?. ### Response: The effect of pathophysiology.


Instruction: When did Eur J Cardiothorac Surg. 1995;9:568–74?

Output: 1995

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Eur J Cardiothorac Surg. 1995;9:568–74?. ### Response: 1995.


Instruction: What was the final result of the Randomized Ischemic Mitral Evalu-ation (RIME) trial?

Output: Coronary artery bypass surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the final result of the Randomized Ischemic Mitral Evalu-ation (RIME) trial?. ### Response: Coronary artery bypass surgery.


Instruction: What did Acker MA, Parides MK, Perrault LP, et al. do for severe ischemic mitral regurgitation?

Output: Mitral-valve repair versus re-placement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Acker MA, Parides MK, Perrault LP, et al. do for severe ischemic mitral regurgitation?. ### Response: Mitral-valve repair versus re-placement.


Instruction: What is regurgitation?

Output: ischemic mitral

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is regurgitation?. ### Response: ischemic mitral.


Instruction: What are the characteristics of regurgitant volume based on?

Output: primary cardiac lesion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the characteristics of regurgitant volume based on?. ### Response: primary cardiac lesion.


Instruction: When was the J Thorac Cardiovasc Surg published?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Thorac Cardiovasc Surg published?. ### Response: 1999.


Instruction: What is a quality control exercise for echocardiographic assessment of right ventricular size and systolic function?

Output: Accuracy and interobserver concordance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a quality control exercise for echocardiographic assessment of right ventricular size and systolic function?. ### Response: Accuracy and interobserver concordance.


Instruction: What is the name of the procedure performed after tricuspid annuloplasty?

Output: Determinants of recurrent or residual functional tricuspid regurgitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the procedure performed after tricuspid annuloplasty?. ### Response: Determinants of recurrent or residual functional tricuspid regurgitation.


Instruction: What is size and systolic function?

Output: right ventricular

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is size and systolic function?. ### Response: right ventricular.


Instruction: What is a quality control exercise?

Output: Accuracy and interobserver concordance of echocardiographic assessment of right ventricular size and systolic function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a quality control exercise?. ### Response: Accuracy and interobserver concordance of echocardiographic assessment of right ventricular size and systolic function.


Instruction: When was the J Am Soc Echocardiogr.25:709–13?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Soc Echocardiogr.25:709–13?. ### Response: 2012.


Instruction: What is the name of the MRI-derived right ventricular mass, volumes and function study?

Output: Routine breath-hold gradient echo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the MRI-derived right ventricular mass, volumes and function study?. ### Response: Routine breath-hold gradient echo.


Instruction: When did the Int J Cardiovasc Imaging issue 20:509-16?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Int J Cardiovasc Imaging issue 20:509-16?. ### Response: 2004.


Instruction: What was the definition of echocardiography?

Output: American Society of Echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the definition of echocardiography?. ### Response: American Society of Echocardiography.


Instruction: What are the three semi-quantitative methods for assessing right ventricular systolic function from cardiac MRI in patients with acquired heart disease?

Output: Diagnostic accuracy and variability

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the three semi-quantitative methods for assessing right ventricular systolic function from cardiac MRI in patients with acquired heart disease?. ### Response: Diagnostic accuracy and variability.


Instruction: When did Eur Radiol. 2011;21:2111–20?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Eur Radiol. 2011;21:2111–20?. ### Response: 2011.


Instruction: What is the reference right ventricular systolic function normalized to age, gender and body surface area?

Output: diastolic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the reference right ventricular systolic function normalized to age, gender and body surface area?. ### Response: diastolic.


Instruction: What is GRADE?

Output: Quality of theEvidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is GRADE?. ### Response: Quality of theEvidence.


Instruction: What is the risk with VKARisk Difference withEdoxaban (95% CI)All-causemortality8,240(1 study)4442Moderatecbecause ofimprecisionRR 1.05(0.82-1.33)31 per 1,000d2 more per 1,000(from 6 fewer to 10 more)?

Output: Anticipated Absolute Effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk with VKARisk Difference withEdoxaban (95% CI)All-causemortality8,240(1 study)4442Moderatecbecause ofimprecisionRR 1.05(0.82-1.33)31 per 1,000d2 more per 1,000(from 6 fewer to 10 more)?. ### Response: Anticipated Absolute Effects.


Instruction: What is the basis for the assumed risk provided in the footnotes?

Output: the median control group risk across studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the basis for the assumed risk provided in the footnotes?. ### Response: the median control group risk across studies.


Instruction: What percentage of the corresponding risk is based on?

Output: 95% CI) i sbased on the assumed risk in the comparison group and the relative effect of the intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the corresponding risk is based on?. ### Response: 95% CI) i sbased on the assumed risk in the comparison group and the relative effect of the intervention.


Instruction: What is based on the assumed risk in the comparison group and the relative effect of the intervention?

Output: The corresponding risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is based on the assumed risk in the comparison group and the relative effect of the intervention?. ### Response: The corresponding risk.


Instruction: See Table 1 and4legends for expansion of what?

Output: abbreviations and GRADE Working Group grades of evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: See Table 1 and4legends for expansion of what?. ### Response: abbreviations and GRADE Working Group grades of evidence.


Instruction: What was the initial treatment for acute VTE?

Output: heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the initial treatment for acute VTE?. ### Response: heparin.


Instruction: How often is hedoxaban given to patients with creatinine clearance of 30 to 50 mL/min or body weight below 60 kg?

Output: 30 mg once daily

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often is hedoxaban given to patients with creatinine clearance of 30 to 50 mL/min or body weight below 60 kg?. ### Response: 30 mg once daily.


Instruction: What does CI include values suggesting?

Output: no effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CI include values suggesting?. ### Response: no effect.


Instruction: What is suggested as bene fit or harm?

Output: harm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is suggested as bene fit or harm?. ### Response: harm.


Instruction: PE not ruled out what?

Output: Death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: PE not ruled out what?. ### Response: Death.


Instruction: What study did Buller and al23 do?

Output: Hokusai-VTE study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What study did Buller and al23 do?. ### Response: Hokusai-VTE study.


Instruction: What type of microflora populates mucosal surfaces?

Output: endogenous

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of microflora populates mucosal surfaces?. ### Response: endogenous.


Instruction: What is a primary reason for revision of the IEProphylaxis Guidelines?

Output: frequent exposure to randombacteremias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a primary reason for revision of the IEProphylaxis Guidelines?. ### Response: frequent exposure to randombacteremias.


Instruction: What may prevent an exceedingly small number of cases of IE in individuals who undergo a dental, GI tract, or GU tract procedure?

Output: Prophylaxis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may prevent an exceedingly small number of cases of IE in individuals who undergo a dental, GI tract, or GU tract procedure?. ### Response: Prophylaxis.


Instruction: What exceeds the benefit, if any,from prophylactic antibiotic therapy?

Output: The risk of antibiotic-associated adverse events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What exceeds the benefit, if any,from prophylactic antibiotic therapy?. ### Response: The risk of antibiotic-associated adverse events.


Instruction: What may reduce the incidence of bacteremia from daily activities?

Output: Maintenance of optimal oral health and hygiene

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may reduce the incidence of bacteremia from daily activities?. ### Response: Maintenance of optimal oral health and hygiene.


Instruction: What is more important than prophylactic antibiotics for a dental procedure to reduce the risk of IE?

Output: Maintenance of optimal oral health and hygiene

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more important than prophylactic antibiotics for a dental procedure to reduce the risk of IE?. ### Response: Maintenance of optimal oral health and hygiene.


Instruction: What is the name of the disease that causes endocarditis?

Output: Infective Endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease that causes endocarditis?. ### Response: Infective Endocarditis.


Instruction: When was this article published?

Output: May 2, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this article published?. ### Response: May 2, 2023.


Instruction: Who published the 2018 Cholesterol Clinical Practice Guidelines?

Output: Grundy et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2018 Cholesterol Clinical Practice Guidelines?. ### Response: Grundy et al.


Instruction: When did Grundy and colleagues publish the 2018 CHOLOSTERO Clinical Practice Guidelines?

Output: June 18/25, 2019

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Grundy and colleagues publish the 2018 CHOLOSTERO Clinical Practice Guidelines?. ### Response: June 18/25, 2019.


Instruction: What is a CAC score of zero and a high 10 year risk?

Output: ≥20%).

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a CAC score of zero and a high 10 year risk?. ### Response: ≥20%)..


Instruction: How many Agatston units are CAC scores of 1 to 99?

Output: S4.4.2-34 For those with CAC scores of 1 to 99

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many Agatston units are CAC scores of 1 to 99?. ### Response: S4.4.2-34 For those with CAC scores of 1 to 99.


Instruction: What are the 10-year ASCVD event rates for age groups 45 to 54, 55 to 64, and 65 to 74 years?

Output: 3.8%, 6.5%, and 8.3%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the 10-year ASCVD event rates for age groups 45 to 54, 55 to 64, and 65 to 74 years?. ### Response: 3.8%, 6.5%, and 8.3%.


Instruction: What do CAC scores in this range favor?

Output: statin initiation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do CAC scores in this range favor?. ### Response: statin initiation.


Instruction: When is statin initiation only in adults >55 years of age?

Output: S4.4.2-23

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is statin initiation only in adults >55 years of age?. ### Response: S4.4.2-23.


Instruction: What is the risk reclassification modest for?

Output: indi-viduals with CAC scores of 1 to 99

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk reclassification modest for?. ### Response: indi-viduals with CAC scores of 1 to 99.


Instruction: For patients with CAC scores of 1 to 99, it is reasonable to repeat the risk discussion for what?

Output: If these patients remain untreated

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For patients with CAC scores of 1 to 99, it is reasonable to repeat the risk discussion for what?. ### Response: If these patients remain untreated.


Instruction: How long can a repeat CAC measure-ment be useful in reassessing for CAC progression?

Output: 5 to 10 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long can a repeat CAC measure-ment be useful in reassessing for CAC progression?. ### Response: 5 to 10 years.


Instruction: What does a systematic review and meta-analysis suggest knowledge that a patient's CAC score is greater than zero is?

Output: beneficial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does a systematic review and meta-analysis suggest knowledge that a patient's CAC score is greater than zero is?. ### Response: beneficial.


Instruction: What is beneficial to a patient whose CAC score is greater than zero?

Output: knowledge

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is beneficial to a patient whose CAC score is greater than zero?. ### Response: knowledge.


Instruction: What are some examples of candidates for CAC scoring who might benefit from knowing that their CAC scores are zero in Table 8?

Output: S4.4.2-38

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some examples of candidates for CAC scoring who might benefit from knowing that their CAC scores are zero in Table 8?. ### Response: S4.4.2-38.


Instruction: There is an increased likelihood that lifestyle therapies and drug therapy will be started or con-tinued with what?

Output: significant, albeit modest, changes in risk factor levels and predicted risk levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is an increased likelihood that lifestyle therapies and drug therapy will be started or con-tinued with what?. ### Response: significant, albeit modest, changes in risk factor levels and predicted risk levels.


Instruction: What will be started or con-tinued with significant, albeit modest, changes in risk factor levels and predicted risk levels?

Output: lifestyle therapies and drug therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will be started or con-tinued with significant, albeit modest, changes in risk factor levels and predicted risk levels?. ### Response: lifestyle therapies and drug therapy.


Instruction: What may need to address reducing ASCVD risk in higher-risk primary-prevention patients who do not wish to take a statin?

Output: Clinicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may need to address reducing ASCVD risk in higher-risk primary-prevention patients who do not wish to take a statin?. ### Response: Clinicians.


Instruction: What is an alternative to a statin?

Output: cholesterol absorption inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an alternative to a statin?. ### Response: cholesterol absorption inhibitor.


Instruction: What is a cholesterol absorption inhibitor?

Output: One alternative

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a cholesterol absorption inhibitor?. ### Response: One alternative.


Instruction: What is an alternative to a cholesterol absorption inhibitor?

Output: nonsystemic bile acid sequestrant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an alternative to a cholesterol absorption inhibitor?. ### Response: nonsystemic bile acid sequestrant.


Instruction: What did an RCT in adults 40 years of age with advanced CKD and without known CHD at baseline find?

Output: cholesterol absorption inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did an RCT in adults 40 years of age with advanced CKD and without known CHD at baseline find?. ### Response: cholesterol absorption inhibitor.


Instruction: How much did the addition of ezetimibe lower LDL-C at 1 year?

Output: 43 mg/dL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much did the addition of ezetimibe lower LDL-C at 1 year?. ### Response: 43 mg/dL.


Instruction: How long did it take for ezeti-mibe and simvastatin to reduce major athero-sclerotic events?

Output: 4.9 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for ezeti-mibe and simvastatin to reduce major athero-sclerotic events?. ### Response: 4.9 years.


Instruction: What was the median age of the study?

Output: 4.9 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the median age of the study?. ### Response: 4.9 years.


Instruction: How much was the reduction in major atherosclerosis events compared to placebo?

Output: 17%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much was the reduction in major atherosclerosis events compared to placebo?. ### Response: 17%.


Instruction: Mono-therapy reduced what endpoints in a large pri-mary-prevention trial?

Output: CHD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Mono-therapy reduced what endpoints in a large pri-mary-prevention trial?. ### Response: CHD.


Instruction: What can bile acid sequestrants bind other drugs?

Output: other medications must be avoided for 1 hour before and at least 3 to 4 hours after administration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can bile acid sequestrants bind other drugs?. ### Response: other medications must be avoided for 1 hour before and at least 3 to 4 hours after administration.


Instruction: How long must other medications be avoided before and at least 3 to 4 hours after administration?

Output: 1 hour

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long must other medications be avoided before and at least 3 to 4 hours after administration?. ### Response: 1 hour.


Instruction: What can reduce the bile acid sequestrant dose?

Output: Adding psyllium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can reduce the bile acid sequestrant dose?. ### Response: Adding psyllium.


Instruction: What should be considered in a risk dis-cussion that reviews potential for benefit along with tolerability and safety issues?

Output: These therapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered in a risk dis-cussion that reviews potential for benefit along with tolerability and safety issues?. ### Response: These therapies.


Instruction: Benefit from statin therapy is seen in lower-risk individuals?

Output: adults >55 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Benefit from statin therapy is seen in lower-risk individuals?. ### Response: adults >55 years of age.


Instruction: What is the name of the group that treats endocarditis?

Output: Endocarditis TreatmentConsortium Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that treats endocarditis?. ### Response: Endocarditis TreatmentConsortium Group.


Instruction: How long did Ceftriaxone and gentamicin last?

Output: two weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did Ceftriaxone and gentamicin last?. ### Response: two weeks.


Instruction: What was the reason for the treatment of the disease?

Output: penicillin-susceptible streptococci

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the reason for the treatment of the disease?. ### Response: penicillin-susceptible streptococci.


Instruction: When did Clin InfectDis issue 27:1470–1474.116?

Output: 1998

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Clin InfectDis issue 27:1470–1474.116?. ### Response: 1998.


Instruction: How long does it take to treat streptococci with ceftriaxone sodium?

Output: 4 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take to treat streptococci with ceftriaxone sodium?. ### Response: 4 weeks.


Instruction: What is the name of the drug used to treat endocarditis?

Output: Ceftriaxone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used to treat endocarditis?. ### Response: Ceftriaxone.


Instruction: What type of endocarditis is treated with streptomycin-susceptible and resistant?

Output: enterococcal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of endocarditis is treated with streptomycin-susceptible and resistant?. ### Response: enterococcal.


Instruction: What year did Ann Intern Med issue 100:816–823.118?

Output: 1984

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Ann Intern Med issue 100:816–823.118?. ### Response: 1984.


Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al.


Instruction: What is the name of the guideline for management of vavular heart disease?

Output: ACC/AHA Guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the guideline for management of vavular heart disease?. ### Response: ACC/AHA Guideline.


Instruction: When did Otto and colleagues publish their guideline?

Output: 2020 ACC/AHA Guideline for the Management of Valvular Heart DiseaseCirculation. 2021;143:e72–e227. DOI: 10.1161/CIR.0000000000000923 February 2, 2021

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Otto and colleagues publish their guideline?. ### Response: 2020 ACC/AHA Guideline for the Management of Valvular Heart DiseaseCirculation. 2021;143:e72–e227. DOI: 10.1161/CIR.0000000000000923 February 2, 2021.


Instruction: What do Heart Valve Centers and 3) focus on?

Output: patient-centric care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do Heart Valve Centers and 3) focus on?. ### Response: patient-centric care.


Instruction: What is needed to assist cardiologists and patients to make well informed choices?

Output: More acces-sible quality and outcome data are also needed from Comprehensive Valve Centers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed to assist cardiologists and patients to make well informed choices?. ### Response: More acces-sible quality and outcome data are also needed from Comprehensive Valve Centers.


Instruction: What are the evidence gaps and future directions for patients with VHDE?

Output: vidence Gaps Future Directions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the evidence gaps and future directions for patients with VHDE?. ### Response: vidence Gaps Future Directions.


Instruction: Disease mechanisms Basic science to identify specific targets for medical therapy Rheumatic heart disease Primary and secondary prevention Calcific valve disease

Output: advanced imaging endpoints

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Disease mechanisms Basic science to identify specific targets for medical therapy Rheumatic heart disease Primary and secondary prevention Calcific valve disease. ### Response: advanced imaging endpoints.


Instruction: Disease Primary and secondary prevention Calcific valve disease Identification of patients at riskRisk factor interventionPrevention of disease initiationMedical therapy for progressive valve disease (Stage B) Disease mechanisms Basic science to identify specific targets to slow or reverse disease progression Medical intervention Targeted therapy using what?

Output: advanced imaging endpoints

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Disease Primary and secondary prevention Calcific valve disease Identification of patients at riskRisk factor interventionPrevention of disease initiationMedical therapy for progressive valve disease (Stage B) Disease mechanisms Basic science to identify specific targets to slow or reverse disease progression Medical intervention Targeted therapy using what?. ### Response: advanced imaging endpoints.


Instruction: What type of therapy is used to study disease mechanisms?

Output: Medical intervention Targeted therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is used to study disease mechanisms?. ### Response: Medical intervention Targeted therapy.


Instruction: What is the name of the stage of intervention?

Output: Stage C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the stage of intervention?. ### Response: Stage C.


Instruction: How is the timing of intervention determined?

Output: Validation of newer measures of LV size (eg, volumes instead of dimension) and function (eg, strain)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the timing of intervention determined?. ### Response: Validation of newer measures of LV size (eg, volumes instead of dimension) and function (eg, strain).


Instruction: What is Stage C?

Output: Optimal timing of intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Stage C?. ### Response: Optimal timing of intervention.


Instruction: What are newer measures of LV size and function used for?

Output: timing of intervention decisions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are newer measures of LV size and function used for?. ### Response: timing of intervention decisions.


Instruction: What is the name of the research that involves patients in identifying research questions?

Output: Patient-centered research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the research that involves patients in identifying research questions?. ### Response: Patient-centered research.


Instruction: What is asymptomatic severe AS with LV dysfunction?

Output: moderate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is asymptomatic severe AS with LV dysfunction?. ### Response: moderate.


Instruction: What type of research involves patients in identifying research questions, study design, and definition of outcomes?

Output: Patient-centered

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of research involves patients in identifying research questions, study design, and definition of outcomes?. ### Response: Patient-centered.


Instruction: What is appropriate representation of diverse patient populations in RCTs for VHD?

Output: Inclusion of diverse patient groups

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is appropriate representation of diverse patient populations in RCTs for VHD?. ### Response: Inclusion of diverse patient groups.


Instruction: Development and validation of improved decision aids for shared decision making with patients?

Output: Comprehensive Valve Centers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Development and validation of improved decision aids for shared decision making with patients?. ### Response: Comprehensive Valve Centers.


Instruction: What type of valves are more durable than TAVI valves?

Output: surgical and transcatheter valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of valves are more durable than TAVI valves?. ### Response: surgical and transcatheter valves.


Instruction: What kind of anticoagulation is better for mechanical valves than VKA?

Output: Optimal antithrombotic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What kind of anticoagulation is better for mechanical valves than VKA?. ### Response: Optimal antithrombotic therapy.


Instruction: How are decision aids used?

Output: shared decision-making with patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are decision aids used?. ### Response: shared decision-making with patients.


Instruction: What is an alternative to VKA anticoagulation for mechanical valves?

Output: Optimal antithrombotic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an alternative to VKA anticoagulation for mechanical valves?. ### Response: Optimal antithrombotic therapy.


Instruction: What type of therapy after TAVI Medical therapy after AVR Medical therapy to address ventricular and vascular function

Output: Optimal antithrombotic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy after TAVI Medical therapy after AVR Medical therapy to address ventricular and vascular function. ### Response: Optimal antithrombotic therapy.


Instruction: What is the name of the department of cardiology at the University of Modena & Reggio Emilia?

Output: Department of Biomedical, Metabolic and NeuralSciences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the department of cardiology at the University of Modena & Reggio Emilia?. ### Response: Department of Biomedical, Metabolic and NeuralSciences.


Instruction: Who is the Director of the Cardiology Division at the Univeristy of Reggio emilia in Italy?

Output: Dr Boriani

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Director of the Cardiology Division at the Univeristy of Reggio emilia in Italy?. ### Response: Dr Boriani.


Instruction: Where is the General Clinical Research Center located?

Output: Taipei Veterans General Hospital andNational Yang-Ming University (Dr Chiang), Taipei, Taiwan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the General Clinical Research Center located?. ### Response: Taipei Veterans General Hospital andNational Yang-Ming University (Dr Chiang), Taipei, Taiwan.


Instruction: What university has a Division of Cardiology?

Output: Taipei Veterans General Hospital

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What university has a Division of Cardiology?. ### Response: Taipei Veterans General Hospital.


Instruction: What is the name of the department of Internal Medicine at Riverside University Medical Center in Moreno Valley, CA?

Output: Divisionof Pulmonary and Critical Care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the department of Internal Medicine at Riverside University Medical Center in Moreno Valley, CA?. ### Response: Divisionof Pulmonary and Critical Care.


Instruction: Who is the Director of the Division of Pulmonary, Critical Care, Hyperbaric, and Sleep Medicine at Loma Linda University MedicalCenter?

Output: Dr Fargo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Director of the Division of Pulmonary, Critical Care, Hyperbaric, and Sleep Medicine at Loma Linda University MedicalCenter?. ### Response: Dr Fargo.


Instruction: Where is the Heart Research Institute located?

Output: University of Sydney

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the Heart Research Institute located?. ### Response: University of Sydney.


Instruction: What is the name of the department of cardiology at the University of Sydney?

Output: Concord Hospital

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the department of cardiology at the University of Sydney?. ### Response: Concord Hospital.


Instruction: Where is the Institute of Cardiovascular Sciences located?

Output: University of Bir-mingham, United Kingdom

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the Institute of Cardiovascular Sciences located?. ### Response: University of Bir-mingham, United Kingdom.


Instruction: What country is the Aalborg Thrombosis Research Unit located in?

Output: Denmark

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What country is the Aalborg Thrombosis Research Unit located in?. ### Response: Denmark.


Instruction: Who is the head of the Cardiovascular Medicine Division at the Harvard Medical School?

Output: Dr Ruff

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the head of the Cardiovascular Medicine Division at the Harvard Medical School?. ### Response: Dr Ruff.


Instruction: What is the name of the Division at Harvard Medical School?

Output: Cardiovascular Medicine Division

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Division at Harvard Medical School?. ### Response: Cardiovascular Medicine Division.


Instruction: Where is the Department of Medicine at Stanford University School ofMedicine located?

Output: Stanford, CA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the Department of Medicine at Stanford University School ofMedicine located?. ### Response: Stanford, CA.


Instruction: What is Dr Turakhia's profession?

Output: School ofMedicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Dr Turakhia's profession?. ### Response: School ofMedicine.


Instruction: Where is University College Hospitals NHS Foundation Trust located?

Output: London, United Kingdom

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is University College Hospitals NHS Foundation Trust located?. ### Response: London, United Kingdom.


Instruction: Where is Uniformed Services University of the Health Sciences?

Output: Bethesda, MD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Uniformed Services University of the Health Sciences?. ### Response: Bethesda, MD.


Instruction: What school of medicine is located in Bethesda?

Output: Uniformed Services University of the Health Sciences, F. EdwardHebert School of Medicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What school of medicine is located in Bethesda?. ### Response: Uniformed Services University of the Health Sciences, F. EdwardHebert School of Medicine.


Instruction: What does not replace professional medicalcare and physician advice?

Output: CHEST Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not replace professional medicalcare and physician advice?. ### Response: CHEST Guidelines.


Instruction: What should always be sought for any medical condition?

Output: professional medicalcare and physician advice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should always be sought for any medical condition?. ### Response: professional medicalcare and physician advice.


Instruction: Who funded this study?

Output: American College of Chest Physicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who funded this study?. ### Response: American College of Chest Physicians.


Instruction: Who is a member of the American College of Chest Physicians?

Output: Gregory Y.H. Lip, MD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a member of the American College of Chest Physicians?. ### Response: Gregory Y.H. Lip, MD.


Instruction: What is Gregory Y.H. Lip's profession?

Output: MD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Gregory Y.H. Lip's profession?. ### Response: MD.


Instruction: Who published Evidence-Based Medicine?

Output: Elsevier Inc

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published Evidence-Based Medicine?. ### Response: Elsevier Inc.


Instruction: What are PCSK9 inhibitors extremely expensive and of questionable cost-effectiveness?

Output: secondary prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are PCSK9 inhibitors extremely expensive and of questionable cost-effectiveness?. ### Response: secondary prevention.


Instruction: What is a population where there is evidence of efficacy such as secondary prevention?

Output: PCSK9 inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a population where there is evidence of efficacy such as secondary prevention?. ### Response: PCSK9 inhibitors.


Instruction: A systematic review by Korman et al. (2018) included two what?

Output: cost -effectiveness analyses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A systematic review by Korman et al. (2018) included two what?. ### Response: cost -effectiveness analyses.


Instruction: Korman et al. (2018) included how many cost -effectiveness analyses?

Output: two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Korman et al. (2018) included how many cost -effectiveness analyses?. ### Response: two.


Instruction: What did Korman and colleagues find that PCSK9 inhibitors did not meet the willingness to pay threshold?

Output: $100,000 per additional quality -adjusted life year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Korman and colleagues find that PCSK9 inhibitors did not meet the willingness to pay threshold?. ### Response: $100,000 per additional quality -adjusted life year.


Instruction: What year did Kazi et al. perform a cost -effectiveness analysis?

Output: 2019

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Kazi et al. perform a cost -effectiveness analysis?. ### Response: 2019.


Instruction: What is lacking in the evidence of benefi t?

Output: PCSK 9 inhibitors in primary prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is lacking in the evidence of benefi t?. ### Response: PCSK 9 inhibitors in primary prevention.


Instruction: Why can't the use of PCSK 9 inhibitors be justified?

Output: the evidence of benefi t is lacking

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why can't the use of PCSK 9 inhibitors be justified?. ### Response: the evidence of benefi t is lacking.


Instruction: What is the name of the 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines?

Output: Antithrombotic Therapy and Prevention of Thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines?. ### Response: Antithrombotic Therapy and Prevention of Thrombosis.


Instruction: When was e402 Circulation December 23/30, 2014?

Output: 328

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was e402 Circulation December 23/30, 2014?. ### Response: 328.


Instruction: What is fibrinolytic therapy indicated for in suspected acute myocardial infarction?

Output: collaborative overview of early mortality and major morbidity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is fibrinolytic therapy indicated for in suspected acute myocardial infarction?. ### Response: collaborative overview of early mortality and major morbidity.


Instruction: What is the acronym for Fibrinolytic Therapy Trialists' Collaborative Group?

Output: FTT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Fibrinolytic Therapy Trialists' Collaborative Group?. ### Response: FTT.


Instruction: When did the Lancet issue 343:311–22?

Output: 1994

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Lancet issue 343:311–22?. ### Response: 1994.


Instruction: What is one of the outcomes of multivessel coronary intervention?

Output: first day angiography/angioplasty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the outcomes of multivessel coronary intervention?. ### Response: first day angiography/angioplasty.


Instruction: Topol EJ, Mukherjee D, et al. Outcome of multivessel coronary intervention in the contemporary percutaneous revasculariza-tion era. 2006;97:1585–90.

Output: unstable angina or non-ST-elevation myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Topol EJ, Mukherjee D, et al. Outcome of multivessel coronary intervention in the contemporary percutaneous revasculariza-tion era. 2006;97:1585–90.. ### Response: unstable angina or non-ST-elevation myocardial infarction.


Instruction: Steinhubl SR, Berger PB, Mann JT III, and al. Early and sustained dual oral antiplatelet therapy following percutaneous coronary interventions: a randomized controlled trial?

Output: British Heart Foundation RITA 3 randomised trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Steinhubl SR, Berger PB, Mann JT III, and al. Early and sustained dual oral antiplatelet therapy following percutaneous coronary interventions: a randomized controlled trial?. ### Response: British Heart Foundation RITA 3 randomised trial.


Instruction: What is the name of the randomized controlled trial of coronary intervention?

Output: RITA 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized controlled trial of coronary intervention?. ### Response: RITA 3.


Instruction: When was the JAMA 288:2411–20?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the JAMA 288:2411–20?. ### Response: 2002.


Instruction: What was the outcome of patients with acute non-Q-wave myocardial infarction randomly assigned to?

Output: an invasive as compared with a conservative management strategy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome of patients with acute non-Q-wave myocardial infarction randomly assigned to?. ### Response: an invasive as compared with a conservative management strategy.


Instruction: Infarction Strategies in Hospital (V ANQWISH) Trial Investigators.

Output: Veterans Affairs Non-Q-Wave

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Infarction Strategies in Hospital (V ANQWISH) Trial Investigators.. ### Response: Veterans Affairs Non-Q-Wave.


Instruction: What was the N Engl J Med. 1998;338:1785–92?

Output: Veterans Affairs Non-Q-Wave Infarction Strategies in Hospital (V ANQWISH) Trial Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the N Engl J Med. 1998;338:1785–92?. ### Response: Veterans Affairs Non-Q-Wave Infarction Strategies in Hospital (V ANQWISH) Trial Investigators.


Instruction: What did de Winter RJ, Windhausen F, Cornel JH, et al. do for acute coronary syndromes?

Output: Early invasive versus selectively invasive management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did de Winter RJ, Windhausen F, Cornel JH, et al. do for acute coronary syndromes?. ### Response: Early invasive versus selectively invasive management.


Instruction: What is the name of the randomised trial conducted by the British Heart Foundation?

Output: RITA 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised trial conducted by the British Heart Foundation?. ### Response: RITA 3.


Instruction: What type of angina can be treated with interventional or conservative treatment?

Output: unstable

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of angina can be treated with interventional or conservative treatment?. ### Response: unstable.


Instruction: When was the RITA 3 trial conducted?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the RITA 3 trial conducted?. ### Response: 2002.


Instruction: What is the name of the prospective randomized trial of triage angiography in acute coronary syndromes ineligible for thrombolytic therapy?

Output: The VINO Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective randomized trial of triage angiography in acute coronary syndromes ineligible for thrombolytic therapy?. ### Response: The VINO Study.


Instruction: What does MATE stand for?

Output: throm-bolytic exclusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does MATE stand for?. ### Response: throm-bolytic exclusion.


Instruction: When did the medicine versus angiogram in throm-bolytic exclusion trial take place?

Output: 1998

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the medicine versus angiogram in throm-bolytic exclusion trial take place?. ### Response: 1998.


Instruction: What is the name of the randomized controlled trial in unstable coronary syndromes?

Output: ICTUS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized controlled trial in unstable coronary syndromes?. ### Response: ICTUS.


Instruction: What is a cooling-off strategy called?

Output: pro-longed antithrombotic pretreatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a cooling-off strategy called?. ### Response: pro-longed antithrombotic pretreatment.


Instruction: When was the JAMA 290:1593-9.

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the JAMA 290:1593-9.. ### Response: 2003.


Instruction: What did Spacek R, Widimsky P, Straka Z, et al. study?

Output: Value of first day angiography/angioplasty in evolving Non-ST segment elevation myocardial infarc-tion: an open multicenter randomized trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Spacek R, Widimsky P, Straka Z, et al. study?. ### Response: Value of first day angiography/angioplasty in evolving Non-ST segment elevation myocardial infarc-tion: an open multicenter randomized trial.


Instruction: What is the name of the multicenter randomized trial in which angiography/angioplasty is used in developing Non-ST segment elevation myocardial infarc-tion?

Output: The VINO Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multicenter randomized trial in which angiography/angioplasty is used in developing Non-ST segment elevation myocardial infarc-tion?. ### Response: The VINO Study.


Instruction: What was the outcome of the VINO Study in 2002?

Output: 338

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome of the VINO Study in 2002?. ### Response: 338.


Instruction: How long did the ICTUS trial last?

Output: 5-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the ICTUS trial last?. ### Response: 5-year.


Instruction: Unstable coro-nary Syndromes) trial a randomized comparison of an early invasive versus selective invasive management in patients with what type of coronary syndrome?

Output: non-ST-segment elevation acute coronary syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Unstable coro-nary Syndromes) trial a randomized comparison of an early invasive versus selective invasive management in patients with what type of coronary syndrome?. ### Response: non-ST-segment elevation acute coronary syndrome.


Instruction: How many prospective studies with 55,000 vascular deaths were included in the meta-analysis?

Output: 61

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many prospective studies with 55,000 vascular deaths were included in the meta-analysis?. ### Response: 61.


Instruction: What is low-density lipoprotein cholesterol associated with?

Output: mortality and hospitalization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is low-density lipoprotein cholesterol associated with?. ### Response: mortality and hospitalization.


Instruction: What is the association of low-density lipoprotein cholesterol with mortality and hospitalization in hemodialysis patients?

Output: association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association of low-density lipoprotein cholesterol with mortality and hospitalization in hemodialysis patients?. ### Response: association.


Instruction: When was Blood Purif published?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Blood Purif published?. ### Response: 2005.


Instruction: What is hypocholesterolemia?

Output: asignificant predictor of death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hypocholesterolemia?. ### Response: asignificant predictor of death.


Instruction: What is asignificant predictor of death in a cohort of chronic hemodialysispatients?

Output: Hypocholesterolemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is asignificant predictor of death in a cohort of chronic hemodialysispatients?. ### Response: Hypocholesterolemia.


Instruction: Kidney Int 2002; 61: 1887-1893.19 What is the predictivevalue of commonly measured variables and an evaluation of death ratedifferences between facilities?

Output: Death risk in hemodialysis patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Kidney Int 2002; 61: 1887-1893.19 What is the predictivevalue of commonly measured variables and an evaluation of death ratedifferences between facilities?. ### Response: Death risk in hemodialysis patients.


Instruction: What is the association between LDL cholesterol and inflammation with cardiovascular events and mortality in hemodialysispatients with type 2 diabetes mellitus?

Output: mortality and hospitalization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association between LDL cholesterol and inflammation with cardiovascular events and mortality in hemodialysispatients with type 2 diabetes mellitus?. ### Response: mortality and hospitalization.


Instruction: What is an evaluation of death rating differences between facilities?

Output: Death risk in hemodialysis patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an evaluation of death rating differences between facilities?. ### Response: Death risk in hemodialysis patients.


Instruction: What type of disease is mellitus?

Output: type 2 diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of disease is mellitus?. ### Response: type 2 diabetes.


Instruction: What is the name of the journal that studies the association between cholesterol level and mortality in dialysis patients?

Output: JAMA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies the association between cholesterol level and mortality in dialysis patients?. ### Response: JAMA.


Instruction: What is the association between LDL-C and risk of myocardial infarction in CKD?

Output: mortality and hospitalization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association between LDL-C and risk of myocardial infarction in CKD?. ### Response: mortality and hospitalization.


Instruction: What was the J Am Soc Nephrol 2013; 24:979–986.23.

Output: J Am Soc Nephrol 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the J Am Soc Nephrol 2013; 24:979–986.23.. ### Response: J Am Soc Nephrol 2013.


Instruction: What does Grundy SM mean?

Output: Diabetes and coronary risk equivalency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Grundy SM mean?. ### Response: Diabetes and coronary risk equivalency.


Instruction: What is Clinical Guidelines and EvidenceReview for Lipid Modification?

Output: Cardiovascular Risk Assessment and thePrimary and Secondary Prevention of Cardiovascular Disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Clinical Guidelines and EvidenceReview for Lipid Modification?. ### Response: Cardiovascular Risk Assessment and thePrimary and Secondary Prevention of Cardiovascular Disease.


Instruction: What is the purpose of Blood Lipids?

Output: Primary and Secondary Prevention of CardiovascularDisease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of Blood Lipids?. ### Response: Primary and Secondary Prevention of CardiovascularDisease.


Instruction: Where is the National Collaborating Centre for Primary Care located?

Output: London

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the National Collaborating Centre for Primary Care located?. ### Response: London.


Instruction: Where was the Royal College of General Practitioners located in 2008?

Output: London

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where was the Royal College of General Practitioners located in 2008?. ### Response: London.


Instruction: What is the name of the Fourth Joint Task Force of the European Society of Cardiology and othersocieties on cardiovascular disease prevention in clinical practice?

Output: Eur J Cardiovasc Prev Rehabil

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Fourth Joint Task Force of the European Society of Cardiology and othersocieties on cardiovascular disease prevention in clinical practice?. ### Response: Eur J Cardiovasc Prev Rehabil.


Instruction: How many societies are represented in the ESC/EAS Task Force for the management of dyslipidaemias?

Output: nine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many societies are represented in the ESC/EAS Task Force for the management of dyslipidaemias?. ### Response: nine.


Instruction: What is the European Society of Cardiology known as?

Output: ESC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the European Society of Cardiology known as?. ### Response: ESC.


Instruction: What does EAS stand for?

Output: European Atherosclerosis Society

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does EAS stand for?. ### Response: European Atherosclerosis Society.


Instruction: When was the Eur Heart J 32:1769-1818.27?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Eur Heart J 32:1769-1818.27?. ### Response: 2011.


Instruction: What is the name of the apopulation-level cohort study?

Output: Risk of coronary events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the apopulation-level cohort study?. ### Response: Risk of coronary events.


Instruction: What indicates standard errors of the incidence estimates at 3 years of follow-up?

Output: Vertical bars

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates standard errors of the incidence estimates at 3 years of follow-up?. ### Response: Vertical bars.


Instruction: Data shown are truncated at how many years?

Output: 3.5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Data shown are truncated at how many years?. ### Response: 3.5.