Instruction: What must the clinician do as theyapply to a specific patient?

Output: using the best of the guideline recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must the clinician do as theyapply to a specific patient?. ### Response: using the best of the guideline recommendations.


Instruction: Future research will need to focus on what?

Output: novel pharmacolog-ical therapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Future research will need to focus on what?. ### Response: novel pharmacolog-ical therapies.


Instruction: What is critical for patients hospitalized with HF?

Output: an evidence base

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is critical for patients hospitalized with HF?. ### Response: an evidence base.


Instruction: What are regenerative cell-based therapies to restore?

Output: myocardium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are regenerative cell-based therapies to restore?. ### Response: myocardium.


Instruction: CRT, ICD and left ventricular assist devices are examples of what?

Output: new device platforms that will either improve existing tech-nologies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: CRT, ICD and left ventricular assist devices are examples of what?. ### Response: new device platforms that will either improve existing tech-nologies.


Instruction: What is critically needed?

Output: an evidence base

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is critically needed?. ### Response: an evidence base.


Instruction: What is critical needed is an evidence base that clearly identifies best processes ofcare?

Output: morbid devices that are capable ofchanging the natural history of HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is critical needed is an evidence base that clearly identifies best processes ofcare?. ### Response: morbid devices that are capable ofchanging the natural history of HF.


Instruction: What is an urgent need?

Output: preventing the burden of this disease through moresuccessful risk modi ﬁcation, sophisticated screening, perhapsusing speci ﬁc omics technologies (i.e., systems biology), oreffective treatment interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an urgent need?. ### Response: preventing the burden of this disease through moresuccessful risk modi ﬁcation, sophisticated screening, perhapsusing speci ﬁc omics technologies (i.e., systems biology), oreffective treatment interventions.


Instruction: Who is the President of the American College of Cardiology Foundation?

Output: Donna K. Arnett

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the President of the American College of Cardiology Foundation?. ### Response: Donna K. Arnett.


Instruction: Who is the Senior Vice President of Science and Quality?

Output: William J. Oetgen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Senior Vice President of Science and Quality?. ### Response: William J. Oetgen.


Instruction: What is the name of the senior director of science and clinical policy at the American College of Cardiology Foundation/American Heart Association?

Output: Charlene L. May

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the senior director of science and clinical policy at the American College of Cardiology Foundation/American Heart Association?. ### Response: Charlene L. May.


Instruction: Ramadhan III, Specialist, Science and Clinical PolicyWhat is Sarah Jackson, MPH?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Ramadhan III, Specialist, Science and Clinical PolicyWhat is Sarah Jackson, MPH?. ### Response: American Heart Association.


Instruction: Who is the President of the American Heart Association?

Output: Nancy Brown

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the President of the American Heart Association?. ### Response: Nancy Brown.


Instruction: What is the Chief Executive Of ficer?

Output: Shalom Jacobovitz

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Chief Executive Of ficer?. ### Response: Shalom Jacobovitz.


Instruction: Who is the Senior VicePresident, Of fice of Science Operations?

Output: Gayle R. Whitman

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Senior VicePresident, Of fice of Science Operations?. ### Response: Gayle R. Whitman.


Instruction: Who is production manager, Scientific Publications?

Output: Jody Hundley

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is production manager, Scientific Publications?. ### Response: Jody Hundley.


Instruction: What is the name of the Task Force on Practice Guidelines?

Output: F/AHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Practice Guidelines?. ### Response: F/AHA.


Instruction: What is the name of the committee that developed trustworthy clinical practice guidelines?

Output: Committee on Standards

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the committee that developed trustworthy clinical practice guidelines?. ### Response: Committee on Standards.


Instruction: Where is the Committee on Standards for Systematic Reviews of ComparativeEffectiveness Research located?

Output: Washington, DC: TheNational Academies Press

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the Committee on Standards for Systematic Reviews of ComparativeEffectiveness Research located?. ### Response: Washington, DC: TheNational Academies Press.


Instruction: What year did the Committee on Standards for Systematic Reviews of ComparativeEffectiveness Research publish Finding What Works inHealth Care?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did the Committee on Standards for Systematic Reviews of ComparativeEffectiveness Research publish Finding What Works inHealth Care?. ### Response: 2011.


Instruction: What is the name of the book published by the Institute of Medicine?

Output: Clinical Practice Guidelines We CanTrust

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the book published by the Institute of Medicine?. ### Response: Clinical Practice Guidelines We CanTrust.


Instruction: What may multiple infections be associated with risk of?

Output: stroke and carotid atherosclerosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may multiple infections be associated with risk of?. ### Response: stroke and carotid atherosclerosis.


Instruction: What has failed to find any benefit in the preven-tion of cardiovascular end points?

Output: randomized trials of antibiotic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has failed to find any benefit in the preven-tion of cardiovascular end points?. ### Response: randomized trials of antibiotic therapy.


Instruction: What is a final issue in the role of infection and inflammation in stroke related to?

Output: acute infectious diseases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a final issue in the role of infection and inflammation in stroke related to?. ### Response: acute infectious diseases.


Instruction: What is an example of an acute infectious disease?

Output: influenza

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of an acute infectious disease?. ### Response: influenza.


Instruction: What is a short-term risk factor for stroke?

Output: Hospitalization for infection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a short-term risk factor for stroke?. ### Response: Hospitalization for infection.


Instruction: Hospitalization for infection appears to be what?

Output: a short-term risk factor for stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hospitalization for infection appears to be what?. ### Response: a short-term risk factor for stroke.


Instruction: What has long been observed in association with influenza?

Output: An increase in cardiovascular deaths

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has long been observed in association with influenza?. ### Response: An increase in cardiovascular deaths.


Instruction: How much reduction in the risk of stroke or TIA was associated with treatment with an antiviral agent within 2 days of an influenza diagnosis?

Output: 28%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much reduction in the risk of stroke or TIA was associated with treatment with an antiviral agent within 2 days of an influenza diagnosis?. ### Response: 28%.


Instruction: How many case-control studies and 1 cohort study of influenza were conducted?

Output: 867

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many case-control studies and 1 cohort study of influenza were conducted?. ### Response: 867.


Instruction: How many cases-control studies have shown a reduced risk of stroke associated with vaccination?

Output: 868

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many cases-control studies have shown a reduced risk of stroke associated with vaccination?. ### Response: 868.


Instruction: How many cohort studies have demonstrated a decreased risk of a stroke associated?

Output: 868

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many cohort studies have demonstrated a decreased risk of a stroke associated?. ### Response: 868.


Instruction: What did a pro-spective study in Taiwan find associated with lower all-cause mortality?

Output: influenza vaccination of people >65 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a pro-spective study in Taiwan find associated with lower all-cause mortality?. ### Response: influenza vaccination of people >65 years of age.


Instruction: What is a 65% reduction in stroke?

Output: HR, 0.35; 95% CI, 0.27–0.45

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a 65% reduction in stroke?. ### Response: HR, 0.35; 95% CI, 0.27–0.45.


Instruction: Why have ran-domized trials been advocated?

Output: because of the risk of bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why have ran-domized trials been advocated?. ### Response: because of the risk of bias.


Instruction: What is recommended for people at increased risk of complications from influenza?

Output: influenza vaccinations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for people at increased risk of complications from influenza?. ### Response: influenza vaccinations.


Instruction: What is recommended by the AHA/ACC for the secondary prevention of CVD?

Output: influenza vaccination

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended by the AHA/ACC for the secondary prevention of CVD?. ### Response: influenza vaccination.


Instruction: There have been no recommendations for influenza vaccination in the primary prevention of what?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There have been no recommendations for influenza vaccination in the primary prevention of what?. ### Response: stroke.


Instruction: No studies have identified any increase in the risk of stroke after influenza vaccinations?

Output: There have been no recommendations for influenza vaccination in the primary prevention of stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No studies have identified any increase in the risk of stroke after influenza vaccinations?. ### Response: There have been no recommendations for influenza vaccination in the primary prevention of stroke.


Instruction: What can be useful in lower -ing stroke risk in patients at risk of stroke?

Output: Annual influenza vaccination

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be useful in lower -ing stroke risk in patients at risk of stroke?. ### Response: Annual influenza vaccination.


Instruction: What should patients with chronic inflammatory disease like RA or SLE be considered at increased risk of?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients with chronic inflammatory disease like RA or SLE be considered at increased risk of?. ### Response: stroke.


Instruction: What is a class IIa; Level of Evidence B?

Output: Annual influenza vaccination

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a class IIa; Level of Evidence B?. ### Response: Annual influenza vaccination.


Instruction: What may be considered to iden-tify patients who may be at increased risk of stroke?

Output: phospholipase A2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered to iden-tify patients who may be at increased risk of stroke?. ### Response: phospholipase A2.


Instruction: What is a class IIb; Level of Evidence B?

Output: phospholipase A2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a class IIb; Level of Evidence B?. ### Response: phospholipase A2.


Instruction: What might be considered to decrease stroke risk in patients with hs-CRP >2.0 mg/dL?

Output: Annual influenza vaccination

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What might be considered to decrease stroke risk in patients with hs-CRP >2.0 mg/dL?. ### Response: Annual influenza vaccination.


Instruction: What is not recommended for chronic infections as a means to prevent stroke?

Output: Treatment with antibiotics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended for chronic infections as a means to prevent stroke?. ### Response: Treatment with antibiotics.


Instruction: What is Class III; Level of Evidence?

Output: A

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Class III; Level of Evidence?. ### Response: A.


Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020 Page 50 of 127 absolute risk reduction ( ARR) of CV events?

Output: 0.1 – 1.7%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020 Page 50 of 127 absolute risk reduction ( ARR) of CV events?. ### Response: 0.1 – 1.7%).


Instruction: What percentage lower mortality over four years?

Output: 1.2%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage lower mortality over four years?. ### Response: 1.2%.


Instruction: How long did Mampuya et al. (2013) evaluate the efficacy of intermittent statin dosing?

Output: 9.3% tolerated intermittent dosing, and 27.5% disconti nued statins. Intermittent  dosing regimens  ranged from once weekly to six days per week

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did Mampuya et al. (2013) evaluate the efficacy of intermittent statin dosing?. ### Response: 9.3% tolerated intermittent dosing, and 27.5% disconti nued statins. Intermittent  dosing regimens  ranged from once weekly to six days per week.


Instruction: What percentage of patients tolerated statin in the retrospective cohort study?

Output: 63.2%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients tolerated statin in the retrospective cohort study?. ### Response: 63.2%.


Instruction: What percentage of patients tolerated daily statin dosing?

Output: 63.2%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients tolerated daily statin dosing?. ### Response: 63.2%.


Instruction: What percentage tolerated disconti nud statins?

Output: 27.5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage tolerated disconti nud statins?. ### Response: 27.5%.


Instruction: What group is most commonly used statin?

Output: intermittent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What group is most commonly used statin?. ### Response: intermittent.


Instruction: What percentage of statin prescriptions are in the intermittent group?

Output: 75.2%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of statin prescriptions are in the intermittent group?. ### Response: 75.2%.


Instruction: Dosing both daily and intermittently led to a significantly greater reduction in surrogate endpoints of TC and LDL-C?

Output: statin discontinuation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Dosing both daily and intermittently led to a significantly greater reduction in surrogate endpoints of TC and LDL-C?. ### Response: statin discontinuation.


Instruction: What percentage of patients were taking concomitant lipid- lowering prescription medications and supplement?

Output: 70%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients were taking concomitant lipid- lowering prescription medications and supplement?. ### Response: 70%.


Instruction: What group took a significantly higher rate of supplements than the daily dosing group and discontinuation group?

Output: intermittent dosing group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What group took a significantly higher rate of supplements than the daily dosing group and discontinuation group?. ### Response: intermittent dosing group.


Instruction: What group had higher rates of niacin and bile acid sequestrant use?

Output: intermittent dosing and discontinuation groups

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What group had higher rates of niacin and bile acid sequestrant use?. ### Response: intermittent dosing and discontinuation groups.


Instruction: What did intermittent dosing and discontinuation groups have?

Output: higher rates of niacin and bile acid sequestrant use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did intermittent dosing and discontinuation groups have?. ### Response: higher rates of niacin and bile acid sequestrant use.


Instruction: What is the most common category of statin-related events?

Output: musculoskeletal symptoms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common category of statin-related events?. ### Response: musculoskeletal symptoms.


Instruction: What was a non-significant trend toward in all- cause mortality at eight years for intermittent statin dosing?

Output: a decr ease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a non-significant trend toward in all- cause mortality at eight years for intermittent statin dosing?. ### Response: a decr ease.


Instruction: What is the most common category of statin related events?

Output: musculoskeletal symptoms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common category of statin related events?. ### Response: musculoskeletal symptoms.


Instruction: Musculoskeletal symptoms can be misattributed to what?

Output: s tatins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Musculoskeletal symptoms can be misattributed to what?. ### Response: s tatins.


Instruction: What may lead to statin discontinuation and a reluctance to restart treatment?

Output: musculoskeletal symptoms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may lead to statin discontinuation and a reluctance to restart treatment?. ### Response: musculoskeletal symptoms.


Instruction: How many patients were included in a meta -analysis?

Output: 1,605

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were included in a meta -analysis?. ### Response: 1,605.


Instruction: How many patients were included in the Riaz et al. (2017) review?

Output: over 125,000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were included in the Riaz et al. (2017) review?. ### Response: over 125,000.


Instruction: What was the OR of the statin group compared to the placebo group?

Output: 1.2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the OR of the statin group compared to the placebo group?. ### Response: 1.2.


Instruction: How low is the absolute incidence of serious muscle injury?

Output: 3.4 per 100,000 person -years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How low is the absolute incidence of serious muscle injury?. ### Response: 3.4 per 100,000 person -years.


Instruction: How many people per 100,000 person-years is statin-induced muscle toxicity estimated to be?

Output: 3.4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people per 100,000 person-years is statin-induced muscle toxicity estimated to be?. ### Response: 3.4.


Instruction: Drug- drug interactions, impaired hepatic or renal function, hypothyroidism, advanced age, rheumatologic disorders, vitamin D deficiency, and alcoholism are some of the risk factors that may predispose patients to what?

Output: statin- induced muscle toxicity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Drug- drug interactions, impaired hepatic or renal function, hypothyroidism, advanced age, rheumatologic disorders, vitamin D deficiency, and alcoholism are some of the risk factors that may predispose patients to what?. ### Response: statin- induced muscle toxicity.


Instruction: Vitamin D deficiency, and alcoholism are factors that need to be considered when evaluating what?

Output: statin intolerance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Vitamin D deficiency, and alcoholism are factors that need to be considered when evaluating what?. ### Response: statin intolerance.


Instruction: A washout period is a short-term interruption of a statin to evaluate whether the perceived adverse event is related to what substance?

Output: statin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A washout period is a short-term interruption of a statin to evaluate whether the perceived adverse event is related to what substance?. ### Response: statin.


Instruction: What was not the optimal duration of the washout period?

Output: statin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not the optimal duration of the washout period?. ### Response: statin.


Instruction: Who should undergo a clinical evaluation and TTE before pregnancy?

Output: women with VHD who are contemplating pregnancy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should undergo a clinical evaluation and TTE before pregnancy?. ### Response: women with VHD who are contemplating pregnancy.


Instruction: Women with severe valve disease should undergo pre-pregnancy counseling by a cardiologist with expertise in managing women with VHD during pregnancy.

Output: risks of pregnancy for the mother and fetus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Women with severe valve disease should undergo pre-pregnancy counseling by a cardiologist with expertise in managing women with VHD during pregnancy.. ### Response: risks of pregnancy for the mother and fetus.


Instruction: What should be monitored in a tertiary-care center with a dedicated Heart Valve Team?

Output: Pregnant women with severe valve disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be monitored in a tertiary-care center with a dedicated Heart Valve Team?. ### Response: Pregnant women with severe valve disease.


Instruction: What are Stages C and D of severe valve disease?

Output: Women with severe valve disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are Stages C and D of severe valve disease?. ### Response: Women with severe valve disease.


Instruction: What is the management of high-risk cardiac conditions during pregnancy?

Output: Pre-pregnancy counseling

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the management of high-risk cardiac conditions during pregnancy?. ### Response: Pre-pregnancy counseling.


Instruction: What is reasonable in asymptomatic women with severe valve disease?

Output: exercise testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable in asymptomatic women with severe valve disease?. ### Response: exercise testing.


Instruction: Exercise testing is reasonable before pregnancy for what?

Output: risk assessment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Exercise testing is reasonable before pregnancy for what?. ### Response: risk assessment.


Instruction: What is the best time for a comprehensive evaluation of a woman with VHD and her baby?

Output: before the time of conception

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the best time for a comprehensive evaluation of a woman with VHD and her baby?. ### Response: before the time of conception.


Instruction: What are the frequency and intensity of follow-up and treatment heavily dependent on during pregnancies?

Output: type and sever -ity of valve lesion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the frequency and intensity of follow-up and treatment heavily dependent on during pregnancies?. ### Response: type and sever -ity of valve lesion.


Instruction: What are the risks to the mother and fetus during pregnancy highly dependent on?

Output: valve disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the risks to the mother and fetus during pregnancy highly dependent on?. ### Response: valve disease.


Instruction: What is a complete TTE with full anatomic and hemodynamic assessment of the valves?

Output: Clinical evaluation of women with VHD who are contemplating pregnancy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a complete TTE with full anatomic and hemodynamic assessment of the valves?. ### Response: Clinical evaluation of women with VHD who are contemplating pregnancy.


Instruction: What is a congenital bicuspid or unicuspid aortic valve associated with?

Output: dilation of the aortic sinuses, the ascending aorta, or both

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a congenital bicuspid or unicuspid aortic valve associated with?. ### Response: dilation of the aortic sinuses, the ascending aorta, or both.


Instruction: What is often associated with dilation of the Aortic sinuses, the ascending Aorta or both?

Output: A con-genital bicuspid or unicuspid aortic valve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is often associated with dilation of the Aortic sinuses, the ascending Aorta or both?. ### Response: A con-genital bicuspid or unicuspid aortic valve.


Instruction: Why does valve include assessment of the aorta before pregnancy?

Output: because of the risk of further aortic enlargement and aortic dissection during pregnancy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why does valve include assessment of the aorta before pregnancy?. ### Response: because of the risk of further aortic enlargement and aortic dissection during pregnancy.


Instruction: What is a risk of further enlargement and dissection?

Output: congenitally abnormal aortic valve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk of further enlargement and dissection?. ### Response: congenitally abnormal aortic valve.


Instruction: Pre-pregnancy counseling with a cardiologist allows discussion of the risks of pregnancy for the mother and fetus?

Output: 1–52

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Pre-pregnancy counseling with a cardiologist allows discussion of the risks of pregnancy for the mother and fetus?. ### Response: 1–52.


Instruction: What is the role of pregnancy for the mother and fetus?

Output: managing women with valve disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of pregnancy for the mother and fetus?. ### Response: managing women with valve disease.


Instruction: What is a complete assessment of functional capacity, severity of valve lesions, status of the LV and RV, and pulmonary status?

Output: TTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a complete assessment of functional capacity, severity of valve lesions, status of the LV and RV, and pulmonary status?. ### Response: TTE.


Instruction: What type of patients have a poorer prognosis than patients without pulmonary hypertension?

Output: ACHD with similar histo-ries and anatomic abnormalities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of patients have a poorer prognosis than patients without pulmonary hypertension?. ### Response: ACHD with similar histo-ries and anatomic abnormalities.


Instruction: What are the fields of ACHD and pulmonary vascular disease care increasingly disparate but complementary?

Output: bodies of know-ledge

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the fields of ACHD and pulmonary vascular disease care increasingly disparate but complementary?. ### Response: bodies of know-ledge.


Instruction: What are increasingly disparate but complementary bodies of know-ledge necessary to achieve for patients with PAH?

Output: op-timal outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are increasingly disparate but complementary bodies of know-ledge necessary to achieve for patients with PAH?. ### Response: op-timal outcomes.


Instruction: What are clinicians cross-trained in both subspecialties or partnering experts from each subspecialty?

Output: to fully counsel patients with ACHD with PAH re-garding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are clinicians cross-trained in both subspecialties or partnering experts from each subspecialty?. ### Response: to fully counsel patients with ACHD with PAH re-garding.


Instruction: What are some of the factors that contribute to PAH?

Output: prognosis, lifestyle choices

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the factors that contribute to PAH?. ### Response: prognosis, lifestyle choices.


Instruction: What is one of the reasons for PAH development?

Output: Anatomic defects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the reasons for PAH development?. ### Response: Anatomic defects.


Instruction: How long can PAH develop in patients with ACHD?

Output: years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long can PAH develop in patients with ACHD?. ### Response: years.


Instruction: What can develop years after shunt closure in patients with ACHD?

Output: PAH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can develop years after shunt closure in patients with ACHD?. ### Response: PAH.


Instruction: What are some predictors for the develop-ment or presence of PAH?

Output: Anatomic defects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some predictors for the develop-ment or presence of PAH?. ### Response: Anatomic defects.


Instruction: What type of abnormalities are associated with ACHD AP classification II or III?

Output: Anatomic defects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of abnormalities are associated with ACHD AP classification II or III?. ### Response: Anatomic defects.


Instruction: Preintervention Qp:Qs 3 and/or PASP >40 mm Hg.?

Output: Preintervention Qp:Qs ≥3 and/or PASP >40 mm Hg.c.  Presence of associated syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Preintervention Qp:Qs 3 and/or PASP >40 mm Hg.?. ### Response: Preintervention Qp:Qs ≥3 and/or PASP >40 mm Hg.c.  Presence of associated syndrome.


Instruction: Presence of associated syndrome (eg, Down syndrome)?

Output: Presence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Presence of associated syndrome (eg, Down syndrome)?. ### Response: Presence.


Instruction: What is the frequency of Routine Follow-Up and Testing?

Output: Frequency of Routine Follow-Up and TestingPhysiological  Stage C*

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the frequency of Routine Follow-Up and Testing?. ### Response: Frequency of Routine Follow-Up and TestingPhysiological  Stage C*.


Instruction: Who is the Outpatient ACHD cardiologist?

Output: 6–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Outpatient ACHD cardiologist?. ### Response: 6–.


Instruction: What type of oximetry is performed each visit?

Output: Pulse

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of oximetry is performed each visit?. ### Response: Pulse.


Instruction: What are Tables 3 and 4 for?

Output: details on the ACHD AP classification system

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are Tables 3 and 4 for?. ### Response: details on the ACHD AP classification system.


Instruction: What may be unnecessary in a year when CMR imaging is performed?

Output: Routine TTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be unnecessary in a year when CMR imaging is performed?. ### Response: Routine TTE.


Instruction: CMR may be indicated for assessment of what?

Output: right ventricular function and CHD anatomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: CMR may be indicated for assessment of what?. ### Response: right ventricular function and CHD anatomy.


Instruction: What type of study is recommended with periodic follow-up CMR?

Output: Baseline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of study is recommended with periodic follow-up CMR?. ### Response: Baseline.


Instruction: How long is the walk test?

Output: 6-minute

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the walk test?. ### Response: 6-minute.


Instruction: What is the CPET?

Output: cardiopulmonary exercise test

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the CPET?. ### Response: cardiopulmonary exercise test.


Instruction: What does ACHD mean?

Output: pulmonary hyperten-sion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ACHD mean?. ### Response: pulmonary hyperten-sion.


Instruction: What does CMR stand for?

Output: cardiovascular magnetic resonance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CMR stand for?. ### Response: cardiovascular magnetic resonance.


Instruction: Where can ahajournals.org be found?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can ahajournals.org be found?. ### Response: http://ahajournals.org.


Instruction: What indicates creatine kinase?

Output: CK

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates creatine kinase?. ### Response: CK.


Instruction: What does HIV stand for?

Output: human immunodeficiency virus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does HIV stand for?. ### Response: human immunodeficiency virus.


Instruction: HMGCR stands for what?

Output: 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: HMGCR stands for what?. ### Response: 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase.


Instruction: What is SASE?

Output: statin associated side effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SASE?. ### Response: statin associated side effects.


Instruction: What is ULN?

Output: upper limit of normal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ULN?. ### Response: upper limit of normal.


Instruction: What type of statin is recommended for PCI?

Output: high-dose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of statin is recommended for PCI?. ### Response: high-dose.


Instruction: What is the level of evidence for statin-nave patients?

Output: A

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the level of evidence for statin-nave patients?. ### Response: A.


Instruction: How long-term do statins have in patients with CAD and ACS?

Output: long-term benefits

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long-term do statins have in patients with CAD and ACS?. ### Response: long-term benefits.


Instruction: What do the benefits of statin in ACSbegin early?

Output: before substantial lipid lowering has oc-curred

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do the benefits of statin in ACSbegin early?. ### Response: before substantial lipid lowering has oc-curred.


Instruction: What wasbeneficial when pretreatment was started from 7 days to just before PCI?

Output: Statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What wasbeneficial when pretreatment was started from 7 days to just before PCI?. ### Response: Statins.


Instruction: What is now recognized as a major riskfactor for subsequent mortality?

Output: Periprocedural bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is now recognized as a major riskfactor for subsequent mortality?. ### Response: Periprocedural bleeding.


Instruction: What is recognized as a major riskfactor for subsequent mortality?

Output: Periprocedural bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recognized as a major riskfactor for subsequent mortality?. ### Response: Periprocedural bleeding.


Instruction: Bleeding may lead to what directly?

Output: tomortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Bleeding may lead to what directly?. ### Response: tomortality.


Instruction: What is a comorbidity associated with worse prognosis?

Output: occult cancer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a comorbidity associated with worse prognosis?. ### Response: occult cancer.


Instruction: What is associated with a number of patient factors?

Output: The risk of bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with a number of patient factors?. ### Response: The risk of bleeding.


Instruction: The overall approach to PCIshould be individualized to what?

Output: to minimize both ischemic andbleeding risks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The overall approach to PCIshould be individualized to what?. ### Response: to minimize both ischemic andbleeding risks.


Instruction: What should be individualized to minimize both ischemic and bleeding risks?

Output: The overall approach to PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be individualized to minimize both ischemic and bleeding risks?. ### Response: The overall approach to PCI.


Instruction: What are measures to minimize the risks of bleeding complica-tions discussed in several sections of this guideline?

Output: Vascular closure devices

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are measures to minimize the risks of bleeding complica-tions discussed in several sections of this guideline?. ### Response: Vascular closure devices.


Instruction: What does UFH stand for?

Output: unfractionated heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does UFH stand for?. ### Response: unfractionated heparin.


Instruction: What do patients with CKD avoid?

Output: excess anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do patients with CKD avoid?. ### Response: excess anticoagulation.


Instruction: How are radial artery access sites used?

Output: 350useof radial artery access site,255and avoidance of femoralvein cannulation when possible

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are radial artery access sites used?. ### Response: 350useof radial artery access site,255and avoidance of femoralvein cannulation when possible.


Instruction: What are devices discussed in detail in Section 5.11.4.8?

Output: Vascular closure devices

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are devices discussed in detail in Section 5.11.4.8?. ### Response: Vascular closure devices.


Instruction: What is reasonable in hospitals withouton-site cardiac surgery?

Output: Primary PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable in hospitals withouton-site cardiac surgery?. ### Response: Primary PCI.


Instruction: What is the level of evidence?

Output: B)e594

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the level of evidence?. ### Response: B)e594.


Instruction: When was this article circulated?

Output: December 6, 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this article circulated?. ### Response: December 6, 2011.


Instruction: What is the VA/DoD Clinical Practice Guideline for the Diagnosis and Management of Hypertensi on in the Primary Care Setting March 2020?

Output: Page 100 of 134

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for the Diagnosis and Management of Hypertensi on in the Primary Care Setting March 2020?. ### Response: Page 100 of 134.


Instruction: What is Eplerenoned Spironolactoneb 50-100 mg/day?

Output: daily or divided bid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Eplerenoned Spironolactoneb 50-100 mg/day?. ### Response: daily or divided bid.


Instruction: What is the daily dose of Spironolactoneb?

Output: 50-100 mg/day

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the daily dose of Spironolactoneb?. ### Response: 50-100 mg/day.


Instruction: What is another term for hyperkalemia or severe kidney dysfunction?

Output: hypokalemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for hyperkalemia or severe kidney dysfunction?. ### Response: hypokalemia.


Instruction: How much of a risk of gynecomastia is associated with the use of this drug?

Output: 9%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of a risk of gynecomastia is associated with the use of this drug?. ### Response: 9%).


Instruction: What is higher risk of gynecomastia with spironolactone than eplerenone?

Output: 9%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is higher risk of gynecomastia with spironolactone than eplerenone?. ### Response: 9%).


Instruction: What is effective in resistant hypertension Other Potassium -Sparing Diuretics Amiloride 5-10 mg/daily?

Output: Alpha -Adrenergic Blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is effective in resistant hypertension Other Potassium -Sparing Diuretics Amiloride 5-10 mg/daily?. ### Response: Alpha -Adrenergic Blockers.


Instruction: What is helpful in reducing hypokalemia caused by thiazide diuretics?

Output: Amiloride

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is helpful in reducing hypokalemia caused by thiazide diuretics?. ### Response: Amiloride.


Instruction: What is effective in resistant hypertension?

Output: Alpha -Adrenergic Blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is effective in resistant hypertension?. ### Response: Alpha -Adrenergic Blockers.


Instruction: How many mg/daily is Terazosinb?

Output: 1-16

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mg/daily is Terazosinb?. ### Response: 1-16.


Instruction: How many mg of Propranolol daily is recommended for use in patients with symptomatic BPH Beta -Adrenergic Blockers Noncardioselective?

Output: 200-800

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mg of Propranolol daily is recommended for use in patients with symptomatic BPH Beta -Adrenergic Blockers Noncardioselective?. ### Response: 200-800.


Instruction: Beta -Adrenergic blockers Noncardioselective Propranolol What is the name of the blocker?

Output: Carvedilol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Beta -Adrenergic blockers Noncardioselective Propranolol What is the name of the blocker?. ### Response: Carvedilol.


Instruction: Carvedilol Labetalold Immediate release: how many mg/day (divided bid)?

Output: 80-160

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Carvedilol Labetalold Immediate release: how many mg/day (divided bid)?. ### Response: 80-160.


Instruction: How many mg/day (daily or divided bid) is a Sustained release?

Output: 25-200

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mg/day (daily or divided bid) is a Sustained release?. ### Response: 25-200.


Instruction: What is the daily dose of CKD?

Output: 25-100 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the daily dose of CKD?. ### Response: 25-100 mg.


Instruction: How much of a dose does a divided bid release each day?

Output: 200-800 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of a dose does a divided bid release each day?. ### Response: 200-800 mg.


Instruction: How many mg/day (divided bid) are available?

Output: 200-800

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mg/day (divided bid) are available?. ### Response: 200-800.


Instruction: How long does it take to discontinue with slow taper?

Output: over one week

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take to discontinue with slow taper?. ### Response: over one week.


Instruction: Why do people avoid using non- DHP CCB?

Output: increased risk of bradycardia or heart attack

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why do people avoid using non- DHP CCB?. ### Response: increased risk of bradycardia or heart attack.


Instruction: What happens to cardioselectivity as doses increase?

Output: decrea ses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What happens to cardioselectivity as doses increase?. ### Response: decrea ses.


Instruction: What should be used cautiously in asthma?

Output: Beta -blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be used cautiously in asthma?. ### Response: Beta -blockers.


Instruction: What is evidence available for reduction in morbidity and mortality?

Output: HFrEF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is evidence available for reduction in morbidity and mortality?. ### Response: HFrEF.


Instruction: What is angina?

Output: recent MI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is angina?. ### Response: recent MI.


Instruction: What are beta -blockers used for?

Output: asthma

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are beta -blockers used for?. ### Response: asthma.


Instruction: Who published the 2018 Cholesterol Clinical Practice Guidelines?

Output: Grundy et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2018 Cholesterol Clinical Practice Guidelines?. ### Response: Grundy et al.


Instruction: When did Grundy and colleagues publish the 2018 CHOLOSTERO Clinical Practice Guidelines?

Output: June 18/25, 2019

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Grundy and colleagues publish the 2018 CHOLOSTERO Clinical Practice Guidelines?. ### Response: June 18/25, 2019.


Instruction: What is a CAC score of zero and a high 10 year risk?

Output: ≥20%).

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a CAC score of zero and a high 10 year risk?. ### Response: ≥20%)..


Instruction: How many Agatston units are CAC scores of 1 to 99?

Output: S4.4.2-34 For those with CAC scores of 1 to 99

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many Agatston units are CAC scores of 1 to 99?. ### Response: S4.4.2-34 For those with CAC scores of 1 to 99.


Instruction: What are the 10-year ASCVD event rates for age groups 45 to 54, 55 to 64, and 65 to 74 years?

Output: 3.8%, 6.5%, and 8.3%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the 10-year ASCVD event rates for age groups 45 to 54, 55 to 64, and 65 to 74 years?. ### Response: 3.8%, 6.5%, and 8.3%.


Instruction: What do CAC scores in this range favor?

Output: statin initiation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do CAC scores in this range favor?. ### Response: statin initiation.


Instruction: When is statin initiation only in adults >55 years of age?

Output: S4.4.2-23

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is statin initiation only in adults >55 years of age?. ### Response: S4.4.2-23.


Instruction: What is the risk reclassification modest for?

Output: indi-viduals with CAC scores of 1 to 99

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk reclassification modest for?. ### Response: indi-viduals with CAC scores of 1 to 99.


Instruction: For patients with CAC scores of 1 to 99, it is reasonable to repeat the risk discussion for what?

Output: If these patients remain untreated

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For patients with CAC scores of 1 to 99, it is reasonable to repeat the risk discussion for what?. ### Response: If these patients remain untreated.


Instruction: How long can a repeat CAC measure-ment be useful in reassessing for CAC progression?

Output: 5 to 10 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long can a repeat CAC measure-ment be useful in reassessing for CAC progression?. ### Response: 5 to 10 years.


Instruction: What does a systematic review and meta-analysis suggest knowledge that a patient's CAC score is greater than zero is?

Output: beneficial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does a systematic review and meta-analysis suggest knowledge that a patient's CAC score is greater than zero is?. ### Response: beneficial.


Instruction: What is beneficial to a patient whose CAC score is greater than zero?

Output: knowledge

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is beneficial to a patient whose CAC score is greater than zero?. ### Response: knowledge.


Instruction: What are some examples of candidates for CAC scoring who might benefit from knowing that their CAC scores are zero in Table 8?

Output: S4.4.2-38

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some examples of candidates for CAC scoring who might benefit from knowing that their CAC scores are zero in Table 8?. ### Response: S4.4.2-38.


Instruction: There is an increased likelihood that lifestyle therapies and drug therapy will be started or con-tinued with what?

Output: significant, albeit modest, changes in risk factor levels and predicted risk levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is an increased likelihood that lifestyle therapies and drug therapy will be started or con-tinued with what?. ### Response: significant, albeit modest, changes in risk factor levels and predicted risk levels.


Instruction: What will be started or con-tinued with significant, albeit modest, changes in risk factor levels and predicted risk levels?

Output: lifestyle therapies and drug therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will be started or con-tinued with significant, albeit modest, changes in risk factor levels and predicted risk levels?. ### Response: lifestyle therapies and drug therapy.


Instruction: What may need to address reducing ASCVD risk in higher-risk primary-prevention patients who do not wish to take a statin?

Output: Clinicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may need to address reducing ASCVD risk in higher-risk primary-prevention patients who do not wish to take a statin?. ### Response: Clinicians.


Instruction: What is an alternative to a statin?

Output: cholesterol absorption inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an alternative to a statin?. ### Response: cholesterol absorption inhibitor.


Instruction: What is a cholesterol absorption inhibitor?

Output: One alternative

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a cholesterol absorption inhibitor?. ### Response: One alternative.


Instruction: What is an alternative to a cholesterol absorption inhibitor?

Output: nonsystemic bile acid sequestrant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an alternative to a cholesterol absorption inhibitor?. ### Response: nonsystemic bile acid sequestrant.


Instruction: What did an RCT in adults 40 years of age with advanced CKD and without known CHD at baseline find?

Output: cholesterol absorption inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did an RCT in adults 40 years of age with advanced CKD and without known CHD at baseline find?. ### Response: cholesterol absorption inhibitor.


Instruction: How much did the addition of ezetimibe lower LDL-C at 1 year?

Output: 43 mg/dL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much did the addition of ezetimibe lower LDL-C at 1 year?. ### Response: 43 mg/dL.


Instruction: How long did it take for ezeti-mibe and simvastatin to reduce major athero-sclerotic events?

Output: 4.9 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for ezeti-mibe and simvastatin to reduce major athero-sclerotic events?. ### Response: 4.9 years.


Instruction: What was the median age of the study?

Output: 4.9 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the median age of the study?. ### Response: 4.9 years.


Instruction: How much was the reduction in major atherosclerosis events compared to placebo?

Output: 17%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much was the reduction in major atherosclerosis events compared to placebo?. ### Response: 17%.


Instruction: Mono-therapy reduced what endpoints in a large pri-mary-prevention trial?

Output: CHD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Mono-therapy reduced what endpoints in a large pri-mary-prevention trial?. ### Response: CHD.


Instruction: What can bile acid sequestrants bind other drugs?

Output: other medications must be avoided for 1 hour before and at least 3 to 4 hours after administration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can bile acid sequestrants bind other drugs?. ### Response: other medications must be avoided for 1 hour before and at least 3 to 4 hours after administration.


Instruction: How long must other medications be avoided before and at least 3 to 4 hours after administration?

Output: 1 hour

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long must other medications be avoided before and at least 3 to 4 hours after administration?. ### Response: 1 hour.


Instruction: What can reduce the bile acid sequestrant dose?

Output: Adding psyllium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can reduce the bile acid sequestrant dose?. ### Response: Adding psyllium.


Instruction: What should be considered in a risk dis-cussion that reviews potential for benefit along with tolerability and safety issues?

Output: These therapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered in a risk dis-cussion that reviews potential for benefit along with tolerability and safety issues?. ### Response: These therapies.


Instruction: Benefit from statin therapy is seen in lower-risk individuals?

Output: adults >55 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Benefit from statin therapy is seen in lower-risk individuals?. ### Response: adults >55 years of age.


Instruction: What is the 2017 VA/SCD Guideline for Circulation?

Output: e272–e391

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2017 VA/SCD Guideline for Circulation?. ### Response: e272–e391.


Instruction: What are the 2017 AHA/ACC/HRS guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death?

Output: Reviewer Relationships With Industry and Other Entities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the 2017 AHA/ACC/HRS guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death?. ### Response: Reviewer Relationships With Industry and Other Entities.


Instruction: What is the date of Cardiac Death?

Output: July 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the date of Cardiac Death?. ### Response: July 2017.


Instruction: Who is the Content Reviewer Professor of Medicine at Harvard Medical School?

Output: Alfred E. Buxton

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Content Reviewer Professor of Medicine at Harvard Medical School?. ### Response: Alfred E. Buxton.


Instruction: Which company is the content reviewer professor of medicine at Harvard?

Output: Medtronic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which company is the content reviewer professor of medicine at Harvard?. ### Response: Medtronic.


Instruction: Who is a Content Reviewer Professor of Medicine at the University of Pennsylvania?

Output: Andrew E. Epstein

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a Content Reviewer Professor of Medicine at the University of Pennsylvania?. ### Response: Andrew E. Epstein.


Instruction: Who is the Chief of Cardiology Section at the Philipadelphia VA Medical Center?

Output: Andrew E. Epstein

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Chief of Cardiology Section at the Philipadelphia VA Medical Center?. ### Response: Andrew E. Epstein.


Instruction: What is the name of the company that defended Amiodarone pulmonary toxicity in 2016?

Output: Amgen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the company that defended Amiodarone pulmonary toxicity in 2016?. ### Response: Amgen.


Instruction: Who is the professor of medicine at Des Moines University?

Output: Brian Olshansky

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the professor of medicine at Des Moines University?. ### Response: Brian Olshansky.


Instruction: Which company does Lundbeck Inc represent?

Output: Boehringer Ingleheim

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which company does Lundbeck Inc represent?. ### Response: Boehringer Ingleheim.


Instruction: On-X/Cryolife is a company that does what?

Output: Lundbeck Inc*

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On-X/Cryolife is a company that does what?. ### Response: Lundbeck Inc*.


Instruction: What company is on-X/Cryolife?

Output: Lundbeck Inc

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What company is on-X/Cryolife?. ### Response: Lundbeck Inc.


Instruction: What is the name of the company that is DSMB?

Output: Medtronic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the company that is DSMB?. ### Response: Medtronic.


Instruction: Who was the Content Reviewer Division Chief of Pediatric Cardiology at Children's National Medical Center?

Output: Charles I. Berul

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the Content Reviewer Division Chief of Pediatric Cardiology at Children's National Medical Center?. ### Response: Charles I. Berul.


Instruction: Who is the Executive Director of the Simon’s Fund?

Output: Darren Sudman

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Executive Director of the Simon’s Fund?. ### Response: Darren Sudman.


Instruction: What is the Chief of Cardiology of the London Health Sciences Center?

Output: George J. Klein

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Chief of Cardiology of the London Health Sciences Center?. ### Response: George J. Klein.


Instruction: Who is a member of the ACC/AHA Task Force on Cardiology?

Output: Boston Scientific

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a member of the ACC/AHA Task Force on Cardiology?. ### Response: Boston Scientific.


Instruction: Who is the ACC/AHA Task Force on Clinical Practice GuidelinesProfessor of Medicine—Baylor College of Medicine Director—Cardiac Care Unit—Michael E. DeBakey Medical Center?

Output: Glenn N. Levine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the ACC/AHA Task Force on Clinical Practice GuidelinesProfessor of Medicine—Baylor College of Medicine Director—Cardiac Care Unit—Michael E. DeBakey Medical Center?. ### Response: Glenn N. Levine.


Instruction: What year did ACC Heart Failure and Transplant Council conduct a content review?

Output: 2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death (July 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did ACC Heart Failure and Transplant Council conduct a content review?. ### Response: 2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death (July 2017.


Instruction: What is the name of the official reviewer at AHADuke University Medical Center?

Output: James P . Daubert

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the official reviewer at AHADuke University Medical Center?. ### Response: James P . Daubert.


Instruction: What is the name of the biopharma company?

Output: ARCA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the biopharma company?. ### Response: ARCA.


Instruction: What is a DSMB?

Output: NHLBI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a DSMB?. ### Response: NHLBI.


Instruction: Which university has a Biosense Webster?

Output: Medtronic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which university has a Biosense Webster?. ### Response: Medtronic.


Instruction: What is the DSMB of NHLBI?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the DSMB of NHLBI?. ### Response: †.


Instruction: What is St. Jude Medical?

Output: DSMB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is St. Jude Medical?. ### Response: DSMB.


Instruction: What is the 2018 ACHD GuidelineAppendix 2 of the 2018 AHA/ACC Guideline for the Management of Adults With Congenital Heart Disease?

Output: Reviewer Relationships With Industry and Other Entities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2018 ACHD GuidelineAppendix 2 of the 2018 AHA/ACC Guideline for the Management of Adults With Congenital Heart Disease?. ### Response: Reviewer Relationships With Industry and Other Entities.


Instruction: Who is the official reviewer for AHA Mayo Clinic?

Output: Samuel J. Asirvatham

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the official reviewer for AHA Mayo Clinic?. ### Response: Samuel J. Asirvatham.


Instruction: What is the name of the professor of medicine at AHA Emory University?

Output: Wendy M. Book

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor of medicine at AHA Emory University?. ### Response: Wendy M. Book.


Instruction: Who is the Chief of the Division of Pediatric Cardiology at DuPont Hospital for Children?

Output: Samuel S. Gidding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Chief of the Division of Pediatric Cardiology at DuPont Hospital for Children?. ### Response: Samuel S. Gidding.


Instruction: Who is a Professor of Medicine at the AHA University of Pennsylvania?

Output: Yuli Y. Kim

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a Professor of Medicine at the AHA University of Pennsylvania?. ### Response: Yuli Y. Kim.


Instruction: Who is a Pediatric Cardiologist at Children's Mercy Hospital?

Output: Geetha Raghuveer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a Pediatric Cardiologist at Children's Mercy Hospital?. ### Response: Geetha Raghuveer.


Instruction: Where is Y. Kim a Professor of Medicine?

Output: AHA University of Pennsylvania

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Y. Kim a Professor of Medicine?. ### Response: AHA University of Pennsylvania.


Instruction: What is the name of the medical director at Children’s Hospital of Philadelphia?

Output: Yuli Y. Kim

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the medical director at Children’s Hospital of Philadelphia?. ### Response: Yuli Y. Kim.


Instruction: Who is the professor of Pediatrics at the University of Missouri?

Output: Kansas City School of Medicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the professor of Pediatrics at the University of Missouri?. ### Response: Kansas City School of Medicine.


Instruction: Who is the official reviewer of Mayo Clinic?

Output: Samuel J. Asirvatham

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the official reviewer of Mayo Clinic?. ### Response: Samuel J. Asirvatham.


Instruction: What is the name of the Associate Professor, Medical College of Wisconsin?

Output: Peter J. Bartz

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Associate Professor, Medical College of Wisconsin?. ### Response: Peter J. Bartz.


Instruction: Who is a co-director of HRSInova Fairfax Children’s Hospital?

Output: Mitchell I. Cohen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a co-director of HRSInova Fairfax Children’s Hospital?. ### Response: Mitchell I. Cohen.


Instruction: Who is the co-director of the Heart Center and Chief, Pediatric Cardiology?

Output: Mitchell I. Cohen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the co-director of the Heart Center and Chief, Pediatric Cardiology?. ### Response: Mitchell I. Cohen.


Instruction: What is the name of the professor of surgery and director of the pediatric heart surgery outcomes research?

Output: Marshall L. Jacobs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor of surgery and director of the pediatric heart surgery outcomes research?. ### Response: Marshall L. Jacobs.


Instruction: Who is the Director of Pediatric and Congenital Interventional Cardiology at the Children’s Hospital Heart Institute?

Output: Joe DiMaggio

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Director of Pediatric and Congenital Interventional Cardiology at the Children’s Hospital Heart Institute?. ### Response: Joe DiMaggio.


Instruction: What is the name of the professor of Cardiothoracic Surgery at the University of Connecticut?

Output: Doff B. McElhinney

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor of Cardiothoracic Surgery at the University of Connecticut?. ### Response: Doff B. McElhinney.


Instruction: Who is a professor of Cardiothoracic Surgery and of Pediatrics at Stanford University?

Output: Doff B. McElhinney

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a professor of Cardiothoracic Surgery and of Pediatrics at Stanford University?. ### Response: Doff B. McElhinney.


Instruction: Who is the Director of Adult Congenital Disease at Peter Munk Cardiac Centre?

Output: Erwin N. Oechslin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Director of Adult Congenital Disease at Peter Munk Cardiac Centre?. ### Response: Erwin N. Oechslin.


Instruction: What is characterized by high spatialresolution of the photon attenuation-corrected images?

Output: Myocardial perfusion PET

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is characterized by high spatialresolution of the photon attenuation-corrected images?. ### Response: Myocardial perfusion PET.


Instruction: What can result from global reductions in myocardial perfusionSPECT?

Output: balanced reduction and an underestimation of ischemicburden

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can result from global reductions in myocardial perfusionSPECT?. ### Response: balanced reduction and an underestimation of ischemicburden.


Instruction: What is PET characterized by high spatialresolution of?

Output: photon attenuation–corrected images

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PET characterized by high spatialresolution of?. ### Response: photon attenuation–corrected images.


Instruction: What are myocardial blood flowtracers used for?

Output: Myocardial perfusion PET is characterized by high spatialresolution of the photon attenuation–corrected images with82Rubidium or13N-ammonia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are myocardial blood flowtracers used for?. ### Response: Myocardial perfusion PET is characterized by high spatialresolution of the photon attenuation–corrected images with82Rubidium or13N-ammonia.


Instruction: PET has a slightly higher (uncorrected) sensitivity for detection of what?

Output: CAD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: PET has a slightly higher (uncorrected) sensitivity for detection of what?. ### Response: CAD.


Instruction: What is the imaging endpoint of pharmacologicalstress CMR?

Output: develop-ment of a new wall motion abnormality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the imaging endpoint of pharmacologicalstress CMR?. ### Response: develop-ment of a new wall motion abnormality.


Instruction: What is a new wall motion abnormality for cine CMR withdobutamine stress?

Output: develop-ment of a new wall motion abnormality for cine CMR withdobutamine stress or a new perfusion abnormality withvasodilator stress

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a new wall motion abnormality for cine CMR withdobutamine stress?. ### Response: develop-ment of a new wall motion abnormality for cine CMR withdobutamine stress or a new perfusion abnormality withvasodilator stress.


Instruction: What is a new perfusion abnormality withvasodilator stress?

Output: wall motion abnormality for cine CMR withdobutamine stress

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a new perfusion abnormality withvasodilator stress?. ### Response: wall motion abnormality for cine CMR withdobutamine stress.


Instruction: What percentage of uncorrected diagnostic sensitivity and specificity of dobutamine-induced CMR wall motion imaging was found to be?

Output: 83%and 86%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of uncorrected diagnostic sensitivity and specificity of dobutamine-induced CMR wall motion imaging was found to be?. ### Response: 83%and 86%,.


Instruction: What percentage of CMR MPI were 91% and 81% respectively?

Output: uncorrected diagnostic sensitivity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of CMR MPI were 91% and 81% respectively?. ### Response: uncorrected diagnostic sensitivity.


Instruction: What has a high negative predictive value for obstructive CAD?

Output: normal CMR perfusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has a high negative predictive value for obstructive CAD?. ### Response: normal CMR perfusion.


Instruction: How many patients were enrolled in a multicenter study that demonstrated similar diagnostic accuracy between CMR perfusion andSPECT MPI?

Output: 234

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were enrolled in a multicenter study that demonstrated similar diagnostic accuracy between CMR perfusion andSPECT MPI?. ### Response: 234.


Instruction: What does SPECT MPI do in detecting obstructive CAD?

Output: diagnostic accuracy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does SPECT MPI do in detecting obstructive CAD?. ### Response: diagnostic accuracy.


Instruction: What did a randomized study of 752 patients directly compare with phar-macological stress CMR?

Output: SPECT MPI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a randomized study of 752 patients directly compare with phar-macological stress CMR?. ### Response: SPECT MPI.


Instruction: What did CMR wall motion have high accuracy fordetection of in patients with suboptimalechocardiographic acoustic window?

Output: obstructive CAD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did CMR wall motion have high accuracy fordetection of in patients with suboptimalechocardiographic acoustic window?. ### Response: obstructive CAD.


Instruction: What showed higher accuracy than CMR dobutamine echocardiography wall motion?

Output: dobutaminewall motion imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What showed higher accuracy than CMR dobutamine echocardiography wall motion?. ### Response: dobutaminewall motion imaging.


Instruction: What does LGE stand for?

Output: gadolinium enhancement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does LGE stand for?. ### Response: gadolinium enhancement.


Instruction: What is LGE imaging used to delineate in scarredmyocardium?

Output: the extent and severity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is LGE imaging used to delineate in scarredmyocardium?. ### Response: the extent and severity.


Instruction: What can be combined with PET and CT or SPECT andCT?

Output: anatomic and functionaltesting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be combined with PET and CT or SPECT andCT?. ### Response: anatomic and functionaltesting.


Instruction: What has allowed assessment of perfusion and FFR by CCTA?

Output: newer scanning techniques

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has allowed assessment of perfusion and FFR by CCTA?. ### Response: newer scanning techniques.


Instruction: What does BMJ stand for?

Output: 1988;297:663–8. 98

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does BMJ stand for?. ### Response: 1988;297:663–8. 98.


Instruction: What does Xin X, He J, Frontini MG, et al. have to say about alcohol reduction on blood pressure?

Output: Effects of alcohol reduction on blood pressure: a meta-analysis of randomized controlled trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Xin X, He J, Frontini MG, et al. have to say about alcohol reduction on blood pressure?. ### Response: Effects of alcohol reduction on blood pressure: a meta-analysis of randomized controlled trials.


Instruction: In what year was Hypertension published?

Output: 2001

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was Hypertension published?. ### Response: 2001.


Instruction: What are the results of the Trials of Hypertension Prevention, Phase I?

Output: The effects of nonpharmacologic interventions on blood pressure of persons with high normal levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of the Trials of Hypertension Prevention, Phase I?. ### Response: The effects of nonpharmacologic interventions on blood pressure of persons with high normal levels.


Instruction: What is the name of the study that examined the effects of weight loss and sodium reduction on blood pressure and hypertension incidence in overweight people?

Output: Trials of Hypertension Prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined the effects of weight loss and sodium reduction on blood pressure and hypertension incidence in overweight people?. ### Response: Trials of Hypertension Prevention.


Instruction: What is the name of the research group that studies the prevention of hypertension?

Output: The Trials of Hypertension Prevention Collaborative Research Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the research group that studies the prevention of hypertension?. ### Response: The Trials of Hypertension Prevention Collaborative Research Group.


Instruction: What was the title of the study?

Output: Trials of Hypertension Prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the title of the study?. ### Response: Trials of Hypertension Prevention.


Instruction: When was the study released?

Output: May 3, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the study released?. ### Response: May 3, 2023.


Instruction: How many trials of antihy-pertensive therapy did a meta-analysis of?

Output: 25

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many trials of antihy-pertensive therapy did a meta-analysis of?. ### Response: 25.


Instruction: What was the pooled RR for stroke of patients receiving antihyper-tensives compared with control subjects?

Output: 0.77

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the pooled RR for stroke of patients receiving antihyper-tensives compared with control subjects?. ### Response: 0.77.


Instruction: The magni-tude of the RR reduction was greater for patients receiving what?

Output: thiazide diuretics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The magni-tude of the RR reduction was greater for patients receiving what?. ### Response: thiazide diuretics.


Instruction: What was the magni-tude of the RR reduction greater for stroke than for most other cardiovascular outcomes?

Output: 232

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the magni-tude of the RR reduction greater for stroke than for most other cardiovascular outcomes?. ### Response: 232.


Instruction: What was greater for other outcomes because of their greater relative frequency?

Output: absolute risk reductions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was greater for other outcomes because of their greater relative frequency?. ### Response: absolute risk reductions.


Instruction: How many trials were involved in a separate meta-analysis?

Output: 13

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many trials were involved in a separate meta-analysis?. ### Response: 13.


Instruction: How many people were treated with ACEIs or ARB?

Output: 80 594

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were treated with ACEIs or ARB?. ### Response: 80 594.


Instruction: How much did ARB therapy reduce the risk of a composite primary outcome including stroke?

Output: 11%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much did ARB therapy reduce the risk of a composite primary outcome including stroke?. ### Response: 11%,.


Instruction: What is the acronym for angiotensin-convert-ing enzyme inhibitor?

Output: ACE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for angiotensin-convert-ing enzyme inhibitor?. ### Response: ACE.


Instruction: What was a significant reduction in fatal and nonfatal strokes?

Output: OR, 0.91

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a significant reduction in fatal and nonfatal strokes?. ### Response: OR, 0.91.


Instruction: Non-ACEI/ARB therapies were allowed, but meta-regression analyses provided evidence that benefits were not due solely to what?

Output: BP reductions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Non-ACEI/ARB therapies were allowed, but meta-regression analyses provided evidence that benefits were not due solely to what?. ### Response: BP reductions.


Instruction: What is the RR of thiazide diuretics?

Output: 0.63

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the RR of thiazide diuretics?. ### Response: 0.63.


Instruction: What has been evaluated by other meta-analyses to offer protection against stroke?

Output: antihypertensive agents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been evaluated by other meta-analyses to offer protection against stroke?. ### Response: antihypertensive agents.


Instruction: What reduced the risk of stroke compared with placebo or no treatment?

Output: calcium channel blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What reduced the risk of stroke compared with placebo or no treatment?. ### Response: calcium channel blockers.


Instruction: What was the baseline BP of thiazide diuretics?

Output: >140/90 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the baseline BP of thiazide diuretics?. ### Response: >140/90 mm Hg.


Instruction: What does cal-cium channel blockers have a slightly greater effect on reducing the risk of stroke compared with placebo or no treatment?

Output: 236

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does cal-cium channel blockers have a slightly greater effect on reducing the risk of stroke compared with placebo or no treatment?. ### Response: 236.