Instruction: Where can you find the Taskforce on Practice Guidelines?

Output: Circulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find the Taskforce on Practice Guidelines?. ### Response: Circulation.


Instruction: What is one of the reasons for the continued evolution of the AHA/ACC clinical practice guideline?

Output: cardio-vascular disease and comorbid conditions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the reasons for the continued evolution of the AHA/ACC clinical practice guideline?. ### Response: cardio-vascular disease and comorbid conditions.


Instruction: What is the name of the Task Force on Clinical Practice Guidelines?

Output: American College of Cardiology/American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Clinical Practice Guidelines?. ### Response: American College of Cardiology/American Heart Association.


Instruction: What is another name for the ACCF/AHA clinical practice guideline methodology summit report?

Output: Task Force on Performance Measures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for the ACCF/AHA clinical practice guideline methodology summit report?. ### Response: Task Force on Performance Measures.


Instruction: What is the name of the summit report on the ACCF/AHA clinical practice guideline methodology?

Output: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Prac-tice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the summit report on the ACCF/AHA clinical practice guideline methodology?. ### Response: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Prac-tice Guidelines.


Instruction: What was the report of the American College of Cardiology Foundation/American Heart Association Task Force on Prac-tice Guidelines?

Output: ACCF/AHA clinical practice guideline methodology summit report

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the report of the American College of Cardiology Foundation/American Heart Association Task Force on Prac-tice Guidelines?. ### Response: ACCF/AHA clinical practice guideline methodology summit report.


Instruction: How long did the guidelines take?

Output: 30-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the guidelines take?. ### Response: 30-year.


Instruction: What was the name of the Task Force on Prac-tice Guidelines?

Output: American College of Cardiology Foundation/American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the Task Force on Prac-tice Guidelines?. ### Response: American College of Cardiology Foundation/American Heart Association.


Instruction: How long was the guideline journey?

Output: 30-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the guideline journey?. ### Response: 30-year.


Instruction: What is the 2013 ACCF/AHA guideline for the management of heart failure?

Output: a report of the American College of Cardiol-ogy Foundation/American Heart Association Task Force on Practice Guide-lines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2013 ACCF/AHA guideline for the management of heart failure?. ### Response: a report of the American College of Cardiol-ogy Foundation/American Heart Association Task Force on Practice Guide-lines.


Instruction: What did the American College of Cardiol-ogy Foundation/American Heart Association Task Force on Practice Guide-lines report on?

Output: management of heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the American College of Cardiol-ogy Foundation/American Heart Association Task Force on Practice Guide-lines report on?. ### Response: management of heart failure.


Instruction: What was the 2013 ACCF/AHA guideline for the management of heart failure?

Output: a report of the American College of Cardiol-ogy Foundation/American Heart Association Task Force on Practice Guide-lines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 2013 ACCF/AHA guideline for the management of heart failure?. ### Response: a report of the American College of Cardiol-ogy Foundation/American Heart Association Task Force on Practice Guide-lines.


Instruction: What year was the ACCF/AHA guideline for the management of heart failure updated?

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the ACCF/AHA guideline for the management of heart failure updated?. ### Response: 2017.


Instruction: How many strokes were there in May 2014?

Output: 1546

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes were there in May 2014?. ### Response: 1546.


Instruction: How many people in the US are living after having had a stroke?

Output: 6.8 million

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people in the US are living after having had a stroke?. ### Response: 6.8 million.


Instruction: What is the fifth-leading cause of death in the United States?

Output: Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the fifth-leading cause of death in the United States?. ### Response: Stroke.


Instruction: How many men will die in 2030?

Output: 72 million

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many men will die in 2030?. ### Response: 72 million.


Instruction: What is the fifth leading cause of death for men?

Output: Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the fifth leading cause of death for men?. ### Response: Stroke.


Instruction: How many people will be over 65 by 2030? What percentage of the population will be women?

Output: 19%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people will be over 65 by 2030? What percentage of the population will be women?. ### Response: 19%.


Instruction: What percentage of stroke survivors have residual deficits 6 months after stroke?

Output: Nearly half

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of stroke survivors have residual deficits 6 months after stroke?. ### Response: Nearly half.


Instruction: How many more disabled women have stroke than men?

Output: ≈200 000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many more disabled women have stroke than men?. ### Response: ≈200 000.


Instruction: Why are women more likely to be living alone and wid-owed before stroke?

Output: women live longer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why are women more likely to be living alone and wid-owed before stroke?. ### Response: women live longer.


Instruction: What is the lifetime risk of stroke in those aged 55 to 75 years?

Output: higher in women (20%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the lifetime risk of stroke in those aged 55 to 75 years?. ### Response: higher in women (20%).


Instruction: Who are more likely to be living alone and wid-owed before stroke?

Output: Women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who are more likely to be living alone and wid-owed before stroke?. ### Response: Women.


Instruction: What are women more adversely affected by than men?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are women more adversely affected by than men?. ### Response: stroke.


Instruction: How does society adapt to the anticipated increase in stroke prevalence?

Output: women will increasingly outnumber men

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does society adapt to the anticipated increase in stroke prevalence?. ### Response: women will increasingly outnumber men.


Instruction: What is the anticipated increase in stroke prevalence in women?

Output: How our society adapts to the anticipated increase in stroke prevalence in women is vitally important

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the anticipated increase in stroke prevalence in women?. ### Response: How our society adapts to the anticipated increase in stroke prevalence in women is vitally important.


Instruction: What is critical to identify women at higher risk for stroke and initiate the appropriate prevention strategies?

Output: it is critical to identify women at higher risk for stroke and initiate the appropriate prevention strategies.Despite the importance of stroke in women, there has never been an American Heart Association (AHA)/American Stroke Association guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is critical to identify women at higher risk for stroke and initiate the appropriate prevention strategies?. ### Response: it is critical to identify women at higher risk for stroke and initiate the appropriate prevention strategies.Despite the importance of stroke in women, there has never been an American Heart Association (AHA)/American Stroke Association guideline.


Instruction: There has never been a guideline for what?

Output: stroke risk and preven-tion in women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There has never been a guideline for what?. ### Response: stroke risk and preven-tion in women.


Instruction: What does the AHA stand for?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the AHA stand for?. ### Response: American Heart Association.


Instruction: What are some of the ways women differ from men?

Output: genetic differences in immunity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the ways women differ from men?. ### Response: genetic differences in immunity.


Instruction: How many factors do women have in common?

Output: third

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many factors do women have in common?. ### Response: third.


Instruction: What factors can influence risk for stroke and impact stroke outcomes?

Output: women live longer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What factors can influence risk for stroke and impact stroke outcomes?. ### Response: women live longer.


Instruction: What does this document provide a new stroke prevention guideline?

Output: covers topics specific to women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does this document provide a new stroke prevention guideline?. ### Response: covers topics specific to women.


Instruction: What does the com-mittee chair nominate writing group members for?

Output: previous work in relevant topic areas

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the com-mittee chair nominate writing group members for?. ### Response: previous work in relevant topic areas.


Instruction: What is included in current primary and secondary stroke prevention guidelines?

Output: topics specific to women in more detail

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is included in current primary and secondary stroke prevention guidelines?. ### Response: topics specific to women in more detail.


Instruction: What committee approved the work of the Stroke Council's Scientific Statement Oversight Committee?

Output: AHA Stroke Council’s Scientific Statement Oversight Committee and the AHA’s Manuscript Oversight Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What committee approved the work of the Stroke Council's Scientific Statement Oversight Committee?. ### Response: AHA Stroke Council’s Scientific Statement Oversight Committee and the AHA’s Manuscript Oversight Committee.


Instruction: What is one of the disciplines represented in the AHA's scientific statement oversight committee?

Output: neurology, neuroscience research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the disciplines represented in the AHA's scientific statement oversight committee?. ### Response: neurology, neuroscience research.


Instruction: The panel reviewed relevant articles on adults using computerized searches of what?

Output: medical literature

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The panel reviewed relevant articles on adults using computerized searches of what?. ### Response: medical literature.


Instruction: The evidence is organized within the context of what framework?

Output: AHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The evidence is organized within the context of what framework?. ### Response: AHA.


Instruction: What is the age dependence of complete heart block complicating radiofrequency ablation of the atrioventricular nodal slow pathway?

Output: Age dependence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the age dependence of complete heart block complicating radiofrequency ablation of the atrioventricular nodal slow pathway?. ### Response: Age dependence.


Instruction: What is Goldberg AS, Bathina MN, Mickelsen S, et al.?

Output: Long-term outcomes on quality-of-life and health care costs in patients with supraventricular tachycardia (radiofrequency catheter ablation versus medical therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Goldberg AS, Bathina MN, Mickelsen S, et al.?. ### Response: Long-term outcomes on quality-of-life and health care costs in patients with supraventricular tachycardia (radiofrequency catheter ablation versus medical therapy.


Instruction: What is the difference between radiofrequency catheter ablation and medical therapy?

Output: quality of life and healthcare costs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between radiofrequency catheter ablation and medical therapy?. ### Response: quality of life and healthcare costs.


Instruction: What are the two main aspects of supraventricular tachycardia?

Output: radiofrequency catheter ablation versus medical therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the two main aspects of supraventricular tachycardia?. ### Response: radiofrequency catheter ablation versus medical therapy.


Instruction: When was the last issue of Am J Cardiol published?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last issue of Am J Cardiol published?. ### Response: 1999.


Instruction: What is the impact of tachycardia on quality of life and healthcare costs?

Output: Long-term outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact of tachycardia on quality of life and healthcare costs?. ### Response: Long-term outcomes.


Instruction: When was the Am J Cardiol 82:589–93?

Output: 1998

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Am J Cardiol 82:589–93?. ### Response: 1998.


Instruction: How long did it take for patients to maintain high quality of lives after ablation?

Output: 5-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for patients to maintain high quality of lives after ablation?. ### Response: 5-year.


Instruction: What was the result of a large retrospective patient cohort?

Output: Sustained high quality of life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the result of a large retrospective patient cohort?. ### Response: Sustained high quality of life.


Instruction: What is ventricular tachycardia?

Output: radiofrequency catheter ablation versus medical therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ventricular tachycardia?. ### Response: radiofrequency catheter ablation versus medical therapy.


Instruction: What is the name of the large retrospective patient cohort?

Output: Patients’ Perspective on Radiofrequency Catheter Ablation of A VRT and A VNRT Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the large retrospective patient cohort?. ### Response: Patients’ Perspective on Radiofrequency Catheter Ablation of A VRT and A VNRT Study.


Instruction: When was the int J Med Sci.6:28–36?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the int J Med Sci.6:28–36?. ### Response: 2009.


Instruction: How did patients perceive symptoms and quality of life after ablation?

Output: Healthcare utilization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did patients perceive symptoms and quality of life after ablation?. ### Response: Healthcare utilization.


Instruction: What is the effect of radiofrequency ablation treatment on quality of life and anxiety in patients with supraven-tricular tachycardia?

Output: Gender-related differ -ences in outcomes and resource utilization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of radiofrequency ablation treatment on quality of life and anxiety in patients with supraven-tricular tachycardia?. ### Response: Gender-related differ -ences in outcomes and resource utilization.


Instruction: What are the results of gender-related differ-ences in outcomes and resource utilization?

Output: Patients’ Perspective on Radiofrequency Catheter Ablation of A VRT and A VNRT Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of gender-related differ-ences in outcomes and resource utilization?. ### Response: Patients’ Perspective on Radiofrequency Catheter Ablation of A VRT and A VNRT Study.


Instruction: What are gender-related differences in outcomes and resource utilization in patients undergoing radio-frequency ablation of supraventricular tachycardia?

Output: differ -ences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are gender-related differences in outcomes and resource utilization in patients undergoing radio-frequency ablation of supraventricular tachycardia?. ### Response: differ -ences.


Instruction: What are the results from Patients’ Perspective on Radiofrequency Catheter Ablation of A VRT and A VNRT Study?

Output: Gender-related differ -ences in outcomes and resource utilization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results from Patients’ Perspective on Radiofrequency Catheter Ablation of A VRT and A VNRT Study?. ### Response: Gender-related differ -ences in outcomes and resource utilization.


Instruction: What is the name of the patient with drug refractory atrioven-tricular nodal reentrant tachycardia treated with radiofrequency catheter ablation?

Output: Larson MS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the patient with drug refractory atrioven-tricular nodal reentrant tachycardia treated with radiofrequency catheter ablation?. ### Response: Larson MS.


Instruction: When was the Am J Cardiol. 84:471–3, A9. 547?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Am J Cardiol. 84:471–3, A9. 547?. ### Response: 1999.


Instruction: What is one of the key words of this study?

Output: AHA Scientific Statements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the key words of this study?. ### Response: AHA Scientific Statements.


Instruction: After catheter ablation of atrial flutter?

Output: Healthcare utilization and clinical outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: After catheter ablation of atrial flutter?. ### Response: Healthcare utilization and clinical outcomes.


Instruction: What is tachycardia, supraventricular and atrioventricular nodal reentry?

Output: Wolff-Parkinson-White syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is tachycardia, supraventricular and atrioventricular nodal reentry?. ### Response: Wolff-Parkinson-White syndrome.


Instruction: Wolff-Parkinson-White syndrome is associated with what?

Output: catheter ablation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Wolff-Parkinson-White syndrome is associated with what?. ### Response: catheter ablation.


Instruction: What are anti-arrhythmia agents?

Output: ◼ accessory atrioventricular bundle

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are anti-arrhythmia agents?. ### Response: ◼ accessory atrioventricular bundle.


Instruction: What are heart defects, congenital  death, sudden  electrophysiologic techniques, cardiac  sinus tachycardia?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are heart defects, congenital  death, sudden  electrophysiologic techniques, cardiac  sinus tachycardia?. ### Response: ◼.


Instruction: What type of therapy may be considered in patients who cannot tolerate statins?

Output: nonstatin lipid-lowering therapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy may be considered in patients who cannot tolerate statins?. ### Response: nonstatin lipid-lowering therapies.


Instruction: What is not established about nonstatin lipid-lowering therapies?

Output: their efficacy in preventing stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not established about nonstatin lipid-lowering therapies?. ### Response: their efficacy in preventing stroke.


Instruction: What does nonstatin mean?

Output: no change in class or LOE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does nonstatin mean?. ### Response: no change in class or LOE.


Instruction: Why is no longer made reference to a low-density lipoprotein target for statin therapy?

Output: the decision to use moderate or intensive statin therapy depends on estimated risk of future cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is no longer made reference to a low-density lipoprotein target for statin therapy?. ### Response: the decision to use moderate or intensive statin therapy depends on estimated risk of future cardiovascular events.


Instruction: What does the decision to use moderate or intensive statin treatment depend on?

Output: estimated risk of future cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the decision to use moderate or intensive statin treatment depend on?. ### Response: estimated risk of future cardiovascular events.


Instruction: A Mediterranean diet supplemented with nuts may help prevent what?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A Mediterranean diet supplemented with nuts may help prevent what?. ### Response: stroke.


Instruction: What may be considered in lowering the risk of stroke?

Output: blood pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered in lowering the risk of stroke?. ### Response: blood pressure.


Instruction: What is a Mediterranean diet supplemented with nuts?

Output: lowering the risk of stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a Mediterranean diet supplemented with nuts?. ### Response: lowering the risk of stroke.


Instruction: What type of therapy is recommended?

Output: nonstatin lipid-lowering therapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is recommended?. ### Response: nonstatin lipid-lowering therapies.


Instruction: What is recommended for patients with prehypertension?

Output: Annual blood pressure screening for high blood pressure and health-promoting lifestyle modification

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for patients with prehypertension?. ### Response: Annual blood pressure screening for high blood pressure and health-promoting lifestyle modification.


Instruction: What is more important in reducing stroke risk than the choice of a specific agent?

Output: Successful reduction of blood pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more important in reducing stroke risk than the choice of a specific agent?. ### Response: Successful reduction of blood pressure.


Instruction: What should be individualized on the basis of other patient characteristics and medication tolerance?

Output: treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be individualized on the basis of other patient characteristics and medication tolerance?. ### Response: treatment.


Instruction: What is recommended to improve blood pressure control?

Output: Self-measured blood pressure monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended to improve blood pressure control?. ### Response: Self-measured blood pressure monitoring.


Instruction: What is a class I; Level of Evidence A?

Output: Self-measured blood pressure monitoring is recommended to improve blood pressure control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a class I; Level of Evidence A?. ### Response: Self-measured blood pressure monitoring is recommended to improve blood pressure control.


Instruction: What type of person has a body mass index >30 kg/m2?

Output: obese

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of person has a body mass index >30 kg/m2?. ### Response: obese.


Instruction: What is recommended for lowering blood pressure?

Output: weight reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for lowering blood pressure?. ### Response: weight reduction.


Instruction: How are overweight and obesity defined?

Output: on the basis of body mass index

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are overweight and obesity defined?. ### Response: on the basis of body mass index.


Instruction: What is clopidogrel's risk OH, falls, and syncope?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is clopidogrel's risk OH, falls, and syncope?. ### Response: ↑.


Instruction: What is the most potent BP first 3 mo?

Output: ↓BP first 3 mo, then less•  Non-DHP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most potent BP first 3 mo?. ### Response: ↓BP first 3 mo, then less•  Non-DHP.


Instruction: What is the most potent BP first 3 mo, then less?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most potent BP first 3 mo, then less?. ### Response: ↓.


Instruction: What is less PR prolongation than DHP and with age?

Output: ↑age; negative inotropy; ↑SA node sensitivity and ↓HR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is less PR prolongation than DHP and with age?. ### Response: ↑age; negative inotropy; ↑SA node sensitivity and ↓HR.


Instruction: What is the risk of OH, falls, syncope?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of OH, falls, syncope?. ### Response: ↑.


Instruction: What is a risk of baroreceptor response to volume shifts?

Output: ↑Sensitivity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk of baroreceptor response to volume shifts?. ### Response: ↑Sensitivity.


Instruction: What is the risk of hypovolemia-thirst?

Output: May need ↑doses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of hypovolemia-thirst?. ### Response: May need ↑doses.


Instruction: What is a risk of OH/falls?

Output: ↑risk OH, falls, syncope

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk of OH/falls?. ### Response: ↑risk OH, falls, syncope.


Instruction: What is the recommended maximum loading dose?

Output: 400 U and 900 U/h INF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommended maximum loading dose?. ### Response: 400 U and 900 U/h INF.


Instruction: What is more potent anticoagulation per dose with age?

Output: ↑age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more potent anticoagulation per dose with age?. ### Response: ↑age.


Instruction: How much weight-based dosing is recommended?

Output: 60 U/kg loading dose + 12 U/kg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much weight-based dosing is recommended?. ### Response: 60 U/kg loading dose + 12 U/kg.


Instruction: How many U/kg/h INF?

Output: 12

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many U/kg/h INF?. ### Response: 12.


Instruction: What is the recommended max loading dose?

Output: 400 U and 900 U/h INF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommended max loading dose?. ### Response: 400 U and 900 U/h INF.


Instruction: What does aPTT• LMWH Cleared renally?

Output: more predictable dose response

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does aPTT• LMWH Cleared renally?. ### Response: more predictable dose response.


Instruction: What is more predictable dose response than UFH?

Output: LMWH Cleared renally

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more predictable dose response than UFH?. ### Response: LMWH Cleared renally.


Instruction: 30 mL/min–avoid or 1 mg/kg SC q 24 h; CrCl 30–60 ml/min: 75%;Dalteparin: Use caution in older pts with low body weight or what other condition?

Output: renal insufficiency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: 30 mL/min–avoid or 1 mg/kg SC q 24 h; CrCl 30–60 ml/min: 75%;Dalteparin: Use caution in older pts with low body weight or what other condition?. ### Response: renal insufficiency.


Instruction: What does Thrombin Inhibitors• Bivalirudin Cleared renally; more predictable dose response; not dependent on plasma protein levels?

Output: less bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Thrombin Inhibitors• Bivalirudin Cleared renally; more predictable dose response; not dependent on plasma protein levels?. ### Response: less bleeding.


Instruction: What is significantly less bleeding in older pts even with renal dysfunction?

Output: UFH + GP IIb/IIIa with similar efficacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is significantly less bleeding in older pts even with renal dysfunction?. ### Response: UFH + GP IIb/IIIa with similar efficacy.


Instruction: How much less bleeding does UFHLess bleeding than GP IIb/IIIa inhibitor + heparin?

Output: 30 to 60 mL/min

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much less bleeding does UFHLess bleeding than GP IIb/IIIa inhibitor + heparin?. ### Response: 30 to 60 mL/min.


Instruction: Fondaparinux Cleared renally Renal/weight adjust; less bleeding but similar efficacy vs. what in older pts with NSTE-ACS?

Output: enoxaparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Fondaparinux Cleared renally Renal/weight adjust; less bleeding but similar efficacy vs. what in older pts with NSTE-ACS?. ### Response: enoxaparin.


Instruction: CrCl 30 to 60–preferred over what?

Output: enoxaparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: CrCl 30 to 60–preferred over what?. ### Response: enoxaparin.


Instruction: What is CrCl 30 to 60 preferred over?

Output: enoxaparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CrCl 30 to 60 preferred over?. ### Response: enoxaparin.


Instruction: What is good safety profile versus UFH/LMWHP2Y12 Inhibitors?

Output: more predictable dose response

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is good safety profile versus UFH/LMWHP2Y12 Inhibitors?. ### Response: more predictable dose response.


Instruction: What is the name of the Task Force on Practice Guidelines?

Output: American College of Cardiology Foundation/American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Practice Guidelines?. ### Response: American College of Cardiology Foundation/American Heart Association.


Instruction: When was the Methodology Manual and Policies from the ACCF/AHA Task Force On Practice Guidelines released?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Methodology Manual and Policies from the ACCF/AHA Task Force On Practice Guidelines released?. ### Response: 2010.


Instruction: Where can you find the Manual for ACC_AHA Writing Committees?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find the Manual for ACC_AHA Writing Committees?. ### Response: http://assets.cardiosource.com.


Instruction: Who is the Committee on Standards for Developing Trustworthy Clinical Practice Guidelines from?

Output: Institute of Medicine (US

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Committee on Standards for Developing Trustworthy Clinical Practice Guidelines from?. ### Response: Institute of Medicine (US.


Instruction: What is the name of the Committee on Standards for Systematic Reviews of Comparative Effectiveness Research?

Output: Committee on Standards for Developing Trustworthy Clinical Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Committee on Standards for Systematic Reviews of Comparative Effectiveness Research?. ### Response: Committee on Standards for Developing Trustworthy Clinical Practice Guidelines.


Instruction: Where is the Institute of Medicine located?

Output: Washington, DC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the Institute of Medicine located?. ### Response: Washington, DC.


Instruction: What are the standards for developing trustworthy clinical practice guidelines?

Output: Committee on Standards

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the standards for developing trustworthy clinical practice guidelines?. ### Response: Committee on Standards.


Instruction: What is Works in Health Care: Standards for Systematic Reviews published in?

Output: Committee on Standards for Systematic Reviews of Comparative Effectiveness Research, Institute of Medicine (US). Finding What Works in Health Care: Standards for Systematic Reviews. Washington, DC: National Academies Press

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Works in Health Care: Standards for Systematic Reviews published in?. ### Response: Committee on Standards for Systematic Reviews of Comparative Effectiveness Research, Institute of Medicine (US). Finding What Works in Health Care: Standards for Systematic Reviews. Washington, DC: National Academies Press.


Instruction: What is the name of the Task Force on Performance Measures that was created by the American College of Cardiology?

Output: American Heart Association Task Force

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Performance Measures that was created by the American College of Cardiology?. ### Response: American Heart Association Task Force.


Instruction: What is the name of the Task Force on Performance Measures and Practice Guidelines?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Performance Measures and Practice Guidelines?. ### Response: American Heart Association.


Instruction: What are the names of the two Task Forces?

Output: American Heart Association Task Force on Performance Measures and Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the two Task Forces?. ### Response: American Heart Association Task Force on Performance Measures and Task Force on Practice Guidelines.


Instruction: Who is responsible for enhancing application of clinical practice guidelines?

Output: American College of Cardiology/American Heart Association Task Force

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is responsible for enhancing application of clinical practice guidelines?. ### Response: American College of Cardiology/American Heart Association Task Force.


Instruction: What is the acronym for diovascular disease and comorbid conditions?

Output: car

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for diovascular disease and comorbid conditions?. ### Response: car.


Instruction: What does the acronym ACCF/AHA refer to?

Output: Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the acronym ACCF/AHA refer to?. ### Response: Task Force on Practice Guidelines.


Instruction: How long have ACC/AHA clinical practice guidelines been evolving?

Output: 30-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long have ACC/AHA clinical practice guidelines been evolving?. ### Response: 30-year.


Instruction: The American College of Cardiology/American Heart Association Task Force on Practice Guidelines.

Output: The evolution and future of ACC/AHA clinical practice guidelines: a 30-year journey

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The American College of Cardiology/American Heart Association Task Force on Practice Guidelines.. ### Response: The evolution and future of ACC/AHA clinical practice guidelines: a 30-year journey.


Instruction: Circulation. 2014;130:1208–17.

Output: American Heart Association Task Force on Performance Measures and Task Force on Practice Guidelines. Circulation. 2014;129:2329–45

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation. 2014;130:1208–17.. ### Response: American Heart Association Task Force on Performance Measures and Task Force on Practice Guidelines. Circulation. 2014;129:2329–45.


Instruction: Halperin JL, Levine GN, Al-Khatib SM, et al. Further evolution of the ACC/AHA clinical practice guideline recommendation classification system.

Output: 8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Halperin JL, Levine GN, Al-Khatib SM, et al. Further evolution of the ACC/AHA clinical practice guideline recommendation classification system.. ### Response: 8.


Instruction: Who published the 2011 ACCF/AHA/SCAI guideline for percutaneous coronary intervention?

Output: American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2011 ACCF/AHA/SCAI guideline for percutaneous coronary intervention?. ### Response: American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions.


Instruction: What is the name of the Task Force on Clinical Practice Guidelines?

Output: American College of Cardiology/American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Clinical Practice Guidelines?. ### Response: American College of Cardiology/American Heart Association.


Instruction: What did the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions do?

Output: Further evolution of the ACC/AHA clinical practice guideline recommendation classification system: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines [published online ahead of print September 23, 2015]. Circulation. doi:10.1161/CIR.0000000000000312. Accessed December 7, 2015. 9. Levine GN, Bates ER, Blankenship JC, et al. 2011 ACCF/AHA/SCAI guideline for percutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions do?. ### Response: Further evolution of the ACC/AHA clinical practice guideline recommendation classification system: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines [published online ahead of print September 23, 2015]. Circulation. doi:10.1161/CIR.0000000000000312. Accessed December 7, 2015. 9. Levine GN, Bates ER, Blankenship JC, et al. 2011 ACCF/AHA/SCAI guideline for percutaneous coronary intervention.


Instruction: What year did Circulation. 2011;124:e574–651?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Circulation. 2011;124:e574–651?. ### Response: 2011.


Instruction: Who wrote the 2013 ACCF/AHA guideline?

Output: O’Gara PT, Kushner FG, Ascheim DD, et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote the 2013 ACCF/AHA guideline?. ### Response: O’Gara PT, Kushner FG, Ascheim DD, et al.


Instruction: What should pregnant women with mechanical prostheses receive during pregnancy?

Output: therapeutic anticoagulation with frequent monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should pregnant women with mechanical prostheses receive during pregnancy?. ### Response: therapeutic anticoagulation with frequent monitoring.


Instruction: What should women who have mechanical heart valves receive?

Output: therapeutic anticoagulation with frequent monitoring during pregnancy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should women who have mechanical heart valves receive?. ### Response: therapeutic anticoagulation with frequent monitoring during pregnancy.


Instruction: Who should receive therapeutic anticoagulation?

Output: Pregnant women with mechanical prostheses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should receive therapeutic anticoagulation?. ### Response: Pregnant women with mechanical prostheses.


Instruction: What should women with mechanical heart valves not maintain with frequent monitoring be counseled against?

Output: therapeutic anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should women with mechanical heart valves not maintain with frequent monitoring be counseled against?. ### Response: therapeutic anticoagulation.


Instruction: What should be used to choose an anticoagulation strategy for pregnancy?

Output: shared decision-making

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be used to choose an anticoagulation strategy for pregnancy?. ### Response: shared decision-making.


Instruction: What should women be informed about during pregnancy?

Output: VKA during pregnancy is associated with the lowest likelihood of maternal complications but the highest likelihood of miscarriage, fetal death, and congenital abnormalities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should women be informed about during pregnancy?. ### Response: VKA during pregnancy is associated with the lowest likelihood of maternal complications but the highest likelihood of miscarriage, fetal death, and congenital abnormalities.


Instruction: What is associated with the lowest likelihood of maternal complications but the highest likelihood of miscarriage, fetal death and congenital abnormalities?

Output: VKA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with the lowest likelihood of maternal complications but the highest likelihood of miscarriage, fetal death and congenital abnormalities?. ### Response: VKA.


Instruction: What is the target anti-Xa level of LMWH?

Output: 0.8 to 1.2 U/mL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the target anti-Xa level of LMWH?. ### Response: 0.8 to 1.2 U/mL.


Instruction: What should women with mechanical valve prostheses switch to?

Output: UFH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should women with mechanical valve prostheses switch to?. ### Response: UFH.


Instruction: How often should women who are on warfarin switch to intravenous UFH?

Output: 1 week

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often should women who are on warfarin switch to intravenous UFH?. ### Response: 1 week.


Instruction: How many hours after dose) or intravenous UFH at least 1 week before planned delivery?

Output: 4 to 6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many hours after dose) or intravenous UFH at least 1 week before planned delivery?. ### Response: 4 to 6.


Instruction: Pregnant women with mechanical valve prostheses who are on LMWH should switch to what?

Output: UFH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Pregnant women with mechanical valve prostheses who are on LMWH should switch to what?. ### Response: UFH.


Instruction: How many hours before planned delivery should pregnant women stop UFH?

Output: 6 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many hours before planned delivery should pregnant women stop UFH?. ### Response: 6 hours.


Instruction: What should a woman do if labor begins or urgent delivery is required?

Output: cesarean section should be performed after reversal of anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should a woman do if labor begins or urgent delivery is required?. ### Response: cesarean section should be performed after reversal of anticoagulation.


Instruction: How long before planned vaginal delivery should pregnant women with valve prostheses stop UHF?

Output: 6 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long before planned vaginal delivery should pregnant women with valve prostheses stop UHF?. ### Response: 6 hours.


Instruction: What is required in a woman therapeutically anticoagulated with a VKA?

Output: labor begins or urgent delivery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is required in a woman therapeutically anticoagulated with a VKA?. ### Response: labor begins or urgent delivery.


Instruction: What should be performed after reversal of anticoagulation?

Output: cesarean section

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be performed after reversal of anticoagulation?. ### Response: cesarean section.


Instruction: For pregnant women with mechanical prostheses who require a dose of warfarin 5 mg/d to maintain a therapeutic INR?

Output: Pregnant women with mechanical valve prostheses who are on warfarin should switch to twice-daily LMWH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For pregnant women with mechanical prostheses who require a dose of warfarin 5 mg/d to maintain a therapeutic INR?. ### Response: Pregnant women with mechanical valve prostheses who are on warfarin should switch to twice-daily LMWH.


Instruction: What is the therapeutic INR for all 3 trimesters?

Output: warfarin ≤5 mg/d to maintain a therapeutic INR, continuation of warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the therapeutic INR for all 3 trimesters?. ### Response: warfarin ≤5 mg/d to maintain a therapeutic INR, continuation of warfarin.


Instruction: What is reasonable after full discussion with the patient about risks and benefits?

Output: continuation of warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable after full discussion with the patient about risks and benefits?. ### Response: continuation of warfarin.


Instruction: For pregnant women with mechanical prostheses who require >5 mg/d of warfarin to achieve a therapeutic, dose-adjusted LMWH?

Output: reasonable

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For pregnant women with mechanical prostheses who require >5 mg/d of warfarin to achieve a therapeutic, dose-adjusted LMWH?. ### Response: reasonable.


Instruction: What is the target anti-Xa level for LMWH?

Output: 0.8 to 1.2 U/mL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the target anti-Xa level for LMWH?. ### Response: 0.8 to 1.2 U/mL.


Instruction: How often per day is warfarin taken during the first trimester?

Output: 2 times per day

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often per day is warfarin taken during the first trimester?. ### Response: 2 times per day.


Instruction: What is recommended for pregnant women with mechanical prostheses?

Output: therapeutic anticoagulation with frequent monitoring during pregnancy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for pregnant women with mechanical prostheses?. ### Response: therapeutic anticoagulation with frequent monitoring during pregnancy.


Instruction: What is the B-NR10 for pregnant women with mechanical prostheses who require a dose of warfarin >5 mg/d to achieve a therapeutic INR?

Output: reasonable

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the B-NR10 for pregnant women with mechanical prostheses who require a dose of warfarin >5 mg/d to achieve a therapeutic INR?. ### Response: reasonable.


Instruction: What is unavailable to pregnant women who require dose-adjusted LMWH?

Output: continuous intravenous UFH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is unavailable to pregnant women who require dose-adjusted LMWH?. ### Response: continuous intravenous UFH.


Instruction: During the first trimester, with aPTT 2 times control, what is used?

Output: dose-adjusted continuous intravenous UFH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: During the first trimester, with aPTT 2 times control, what is used?. ### Response: dose-adjusted continuous intravenous UFH.


Instruction: What is the second and third trimester followed by?

Output: warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the second and third trimester followed by?. ### Response: warfarin.


Instruction: What is reasonable?

Output: dose-adjusted LMWH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable?. ### Response: dose-adjusted LMWH.


Instruction: When was the ahajournals.org downloaded?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the ahajournals.org downloaded?. ### Response: April 28, 2023.


Instruction: Who edited the Committee on Standards for Developing Trustworthy Clinical Practice Guidelines?

Output: Graham R, Mancher M, Miller Wolman D, et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who edited the Committee on Standards for Developing Trustworthy Clinical Practice Guidelines?. ### Response: Graham R, Mancher M, Miller Wolman D, et al.


Instruction: What is the name of the committee that developed trustworthy clinical practice guidelines?

Output: Committee on Standards

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the committee that developed trustworthy clinical practice guidelines?. ### Response: Committee on Standards.


Instruction: Where is the National Academies Press located?

Output: Wash-ington, DC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the National Academies Press located?. ### Response: Wash-ington, DC.


Instruction: What are the ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction?

Output: ACC/AHA/SCAI guidelines on percutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction?. ### Response: ACC/AHA/SCAI guidelines on percutaneous coronary intervention.


Instruction: What is the name of the Task Force on Practice Guidelines?

Output: American College of Cardiology Foundation/American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Practice Guidelines?. ### Response: American College of Cardiology Foundation/American Heart Association.


Instruction: When did the Committee to Revise the 1999 Guidelines for the Management of Patients With Acute Myocardia Infarction meet?

Output: 2004;110:e82–292. 5. Antman EM, Hand M, Armstrong PW, et al. 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Committee to Revise the 1999 Guidelines for the Management of Patients With Acute Myocardia Infarction meet?. ### Response: 2004;110:e82–292. 5. Antman EM, Hand M, Armstrong PW, et al. 2007.


Instruction: What is the ACC/AHA 2004 guidelines for the management of patients with ST-el-evation myocardial infarction?

Output: Focused update

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ACC/AHA 2004 guidelines for the management of patients with ST-el-evation myocardial infarction?. ### Response: Focused update.


Instruction: What is a report of the American College of Car-diology/American Heart Association Task Force on Practice Guidelines?

Output: Focused update of the ACC/AHA 2004 guidelines for the management of patients with ST-el-evation myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a report of the American College of Car-diology/American Heart Association Task Force on Practice Guidelines?. ### Response: Focused update of the ACC/AHA 2004 guidelines for the management of patients with ST-el-evation myocardial infarction.


Instruction: What is the acronym for the American Heart Association Task Force on Practice Guidelines?

Output: American College of Car -diology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the American Heart Association Task Force on Practice Guidelines?. ### Response: American College of Car -diology.


Instruction: What are the ACC/AHA guidelines for the management of patients with ST-elevation myo-cardial infarction?

Output: updating the 2004 guideline and 2007 focused update) and ACC/AHA/SCAI guidelines on percutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the ACC/AHA guidelines for the management of patients with ST-elevation myo-cardial infarction?. ### Response: updating the 2004 guideline and 2007 focused update) and ACC/AHA/SCAI guidelines on percutaneous coronary intervention.


Instruction: What is the name of the group that updated the 2005 guideline and 2007 focused update on percutaneous coronary intervention?

Output: ACC/AHA/SCAI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that updated the 2005 guideline and 2007 focused update on percutaneous coronary intervention?. ### Response: ACC/AHA/SCAI.


Instruction: What are the names of the groups that revised the 2007 focus update on the percutaneous coronary intervention guidelines?

Output: American College of Car -diology/American Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the groups that revised the 2007 focus update on the percutaneous coronary intervention guidelines?. ### Response: American College of Car -diology/American Heart Association Task Force on Practice Guidelines.


Instruction: When did the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines publish their report?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines publish their report?. ### Response: 2009.


Instruction: What is the third universal definition of myo-cardial infarction?

Output: Thygesen K, Alpert JS, Jaffe AS, et al. Third universal definition of myo-cardial infarction. Circulation. 2012;126:2020–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the third universal definition of myo-cardial infarction?. ### Response: Thygesen K, Alpert JS, Jaffe AS, et al. Third universal definition of myo-cardial infarction. Circulation. 2012;126:2020–.


Instruction: What is another name for left bundle branch block?

Output: Bundle-branch block

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for left bundle branch block?. ### Response: Bundle-branch block.


Instruction: What type of infarction is associated with in-hospital mortality?

Output: ST-segment-elevation myocardial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of infarction is associated with in-hospital mortality?. ### Response: ST-segment-elevation myocardial.


Instruction: What is the name of the organization that studies myocardial infarct?

Output: National Registry of Myocardial Infarction 2 Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that studies myocardial infarct?. ### Response: National Registry of Myocardial Infarction 2 Investigators.


Instruction: When was the last time I had a heart attack?

Output: 1999–2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last time I had a heart attack?. ### Response: 1999–2006.


Instruction: What is a new ECG sign of?

Output: proximal LAD occlusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a new ECG sign of?. ### Response: proximal LAD occlusion.


Instruction: What can predict left main coronary artery lesion in patients with acute myocardial infarction?

Output: Reciprocal changes in 12-lead electrocardi-ography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can predict left main coronary artery lesion in patients with acute myocardial infarction?. ### Response: Reciprocal changes in 12-lead electrocardi-ography.


Instruction: What type of myocardial infarction is more common in black and white patients?

Output: ST-segment-elevation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of myocardial infarction is more common in black and white patients?. ### Response: ST-segment-elevation.


Instruction: What is the association between bleeding and in-hospital mortality?

Output: black and white patients with ST-segment-elevation myocardial infarction receiving reperfusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association between bleeding and in-hospital mortality?. ### Response: black and white patients with ST-segment-elevation myocardial infarction receiving reperfusion.


Instruction: In what year was Circulation 125:1727–34.13?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was Circulation 125:1727–34.13?. ### Response: 2012.


Instruction: What was the decline in rates of death and heart failure in acute coronary syndromes between 1999 and 2006?

Output: 1892–900.14

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the decline in rates of death and heart failure in acute coronary syndromes between 1999 and 2006?. ### Response: 1892–900.14.


Instruction: When did JAMA issue 297: 1892-900.14?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did JAMA issue 297: 1892-900.14?. ### Response: 2007.


Instruction: What is the name of the journal that published a study on the decline of heart failure and death in the period 1999-2006?

Output: JAMA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that published a study on the decline of heart failure and death in the period 1999-2006?. ### Response: JAMA.


Instruction: What is myocardial infarction?

Output: ST-segment-elevation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is myocardial infarction?. ### Response: ST-segment-elevation.


Instruction: When was the N Engl J Med published?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the N Engl J Med published?. ### Response: 2008.


Instruction: What is the second Euro Heart Survey?

Output: Population trends in the inci-dence and outcomes of acute myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the second Euro Heart Survey?. ### Response: Population trends in the inci-dence and outcomes of acute myocardial infarction.


Instruction: Who published the 2018 Cholesterol Clinical Practice Guidelines?

Output: Grundy et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2018 Cholesterol Clinical Practice Guidelines?. ### Response: Grundy et al.


Instruction: What is the name of the study that was published in 2018?

Output: Grundy et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that was published in 2018?. ### Response: Grundy et al.


Instruction: In adults who would benefit from more aggressive LDL-C lowering, what might be reasonable to add?

Output: a nonstatin drug

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In adults who would benefit from more aggressive LDL-C lowering, what might be reasonable to add?. ### Response: a nonstatin drug.


Instruction: What may be reasonable to add a nonstatin drug to a moderate-intensity statin?

Output: intermediate-risk adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be reasonable to add a nonstatin drug to a moderate-intensity statin?. ### Response: intermediate-risk adults.


Instruction: In patients at borderline risk, the presence of risk-enhancing factors may justify initiation of what?

Output: moderate-intensity statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients at borderline risk, the presence of risk-enhancing factors may justify initiation of what?. ### Response: moderate-intensity statin therapy.


Instruction: What includes acute coronary artery disease?

Output: Definition of clinical ASCVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What includes acute coronary artery disease?. ### Response: Definition of clinical ASCVD.


Instruction: What is the definition of clinical ASCVD?

Output: acute coronary syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the definition of clinical ASCVD?. ### Response: acute coronary syndrome.


Instruction: What is a definition of MI?

Output: myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a definition of MI?. ### Response: myocardial infarction.


Instruction: What type of aneurysm are all of atherosclerotic origin?

Output: aortic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of aneurysm are all of atherosclerotic origin?. ### Response: aortic.


Instruction: Adults 40 to 75 years of age in primary prevention can be classified as what?

Output: borderline risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Adults 40 to 75 years of age in primary prevention can be classified as what?. ### Response: borderline risk.


Instruction: What should be considered during risk discussion of ASCVD?

Output: the presence of risk-enhancing factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered during risk discussion of ASCVD?. ### Response: the presence of risk-enhancing factors.


Instruction: What should be considered during risk discussion of treatment options?

Output: moderate- to high-intensity statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered during risk discussion of treatment options?. ### Response: moderate- to high-intensity statin therapy.


Instruction: What are other considerations favoring use of statins in in-termediate-risk patients?

Output: independent risk conditions and, in selected individuals, risk-enhancing factors associated with greater ASCVD risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are other considerations favoring use of statins in in-termediate-risk patients?. ### Response: independent risk conditions and, in selected individuals, risk-enhancing factors associated with greater ASCVD risk.


Instruction: What is the variability of percent LDL-C lowering with high-intensity statin use?

Output: wide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the variability of percent LDL-C lowering with high-intensity statin use?. ### Response: wide.


Instruction: What is its efficacy proportional to the magnitude of?

Output: LDL-C reduction obtained

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is its efficacy proportional to the magnitude of?. ### Response: LDL-C reduction obtained.


Instruction: How do those with higher baseline ASCVD risk derive greater absolute benefit?

Output: higher percent LDL-C reduction with evi-dence-based therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do those with higher baseline ASCVD risk derive greater absolute benefit?. ### Response: higher percent LDL-C reduction with evi-dence-based therapy.


Instruction: What percentage of LDL-C reduction is possible with evi-dence-based therapy?

Output: higher percent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of LDL-C reduction is possible with evi-dence-based therapy?. ### Response: higher percent.


Instruction: What should be reduced by 30% if a statin is given?

Output: LDL-C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be reduced by 30% if a statin is given?. ### Response: LDL-C.


Instruction: What is particularly useful in older adults to improve specificity?

Output: CAC scoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is particularly useful in older adults to improve specificity?. ### Response: CAC scoring.


Instruction: A CAC score of zero revises ASCVD risk downward and selects adults who show reduced benefit from starting a statin?

Output: S4.4.2-15

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A CAC score of zero revises ASCVD risk downward and selects adults who show reduced benefit from starting a statin?. ### Response: S4.4.2-15.


Instruction: Prior guidelines recommended what type of statins?

Output: moderate- or high-intensity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Prior guidelines recommended what type of statins?. ### Response: moderate- or high-intensity.


Instruction: What did prior guidelines recommend as first-line LDL-C-lowering ther-apy in primary prevention of ASCVD?

Output: moderate- or high-intensity statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did prior guidelines recommend as first-line LDL-C-lowering ther-apy in primary prevention of ASCVD?. ### Response: moderate- or high-intensity statins.


Instruction: What was based on 3 large-scale exclusively primary-prevention RCTs that demonstrated that moderate-intensity statin therapy was associated with?

Output: ASCVD risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was based on 3 large-scale exclusively primary-prevention RCTs that demonstrated that moderate-intensity statin therapy was associated with?. ### Response: ASCVD risk.


Instruction: Which statins were associated with ASCVD risk?

Output: moderate-intensity statin therapyS4.4.2-5,S4.4.2-25 and high-intensity statin therapyS4.4.2-6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which statins were associated with ASCVD risk?. ### Response: moderate-intensity statin therapyS4.4.2-5,S4.4.2-25 and high-intensity statin therapyS4.4.2-6.


Instruction: Statin therapyS4.4.2-5, S4.4.2-25, and high-intensity statin therapy S44.2-6 had what effect?

Output: ASCVD risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Statin therapyS4.4.2-5, S4.4.2-25, and high-intensity statin therapy S44.2-6 had what effect?. ### Response: ASCVD risk.


Instruction: What can be useful for patients on GDMT who have LVEF /C2035% and are undergoing new orplacement device implantation with anticipated ventricular pacing ( >40%)?

Output: IIa B 259–264CRT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be useful for patients on GDMT who have LVEF /C2035% and are undergoing new orplacement device implantation with anticipated ventricular pacing ( >40%)?. ### Response: IIa B 259–264CRT.


Instruction: AV nodal ablation or rate control allows near100% what?

Output: ventricular pacing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: AV nodal ablation or rate control allows near100% what?. ### Response: ventricular pacing.


Instruction: What is of uncertain benefit to prolong meaningful survival in patients with a high risk of nonsudden death?

Output: ICD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is of uncertain benefit to prolong meaningful survival in patients with a high risk of nonsudden death?. ### Response: ICD.


Instruction: What may be considered for patients who have LVEF /C2035%, sinus rhythm, a non-LBBB pattern?

Output: 271CRT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered for patients who have LVEF /C2035%, sinus rhythm, a non-LBBB pattern?. ### Response: 271CRT.


Instruction: What may be considered for patients who have LVEF /C2035%, sinus rhythm, a non-LBBB patternwith QRS 120 to 149 ms and NYHA class III/ambulatory class IV on GDMTIIb B 254,272CRT?

Output: IIb B 268–271CRT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered for patients who have LVEF /C2035%, sinus rhythm, a non-LBBB patternwith QRS 120 to 149 ms and NYHA class III/ambulatory class IV on GDMTIIb B 254,272CRT?. ### Response: IIb B 268–271CRT.


Instruction: What may be considered for patients who have LVEF /C2030%, ischemic etiology of HF, sinus rhythm,LBBB?

Output: not recommended

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered for patients who have LVEF /C2030%, ischemic etiology of HF, sinus rhythm,LBBB?. ### Response: not recommended.


Instruction: What is not recommended for patients with NYHA class I?

Output: symptoms on GDMTIIb C 253,254CRT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended for patients with NYHA class I?. ### Response: symptoms on GDMTIIb C 253,254CRT.


Instruction: What is not indicated for patients whose comorbidities and/or frailty limit survival to 1 y?

Output: Beneﬁt B 253,254,272CRT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not indicated for patients whose comorbidities and/or frailty limit survival to 1 y?. ### Response: Beneﬁt B 253,254,272CRT.


Instruction: What should be specific to each individual patient?

Output: Counseling

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be specific to each individual patient?. ### Response: Counseling.


Instruction: What should include documentation of a discussion about the potential for sudden death and nonsuddendeath from HF?

Output: Counseling

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should include documentation of a discussion about the potential for sudden death and nonsuddendeath from HF?. ### Response: Counseling.


Instruction: What does AF mean?

Output: atrial ﬁbrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does AF mean?. ### Response: atrial ﬁbrillation.


Instruction: What does COR stand for?

Output: Class of Recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does COR stand for?. ### Response: Class of Recommendation.


Instruction: When is the potential for inactivation of ICDs?

Output: when a patient is approaching end of life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is the potential for inactivation of ICDs?. ### Response: when a patient is approaching end of life.


Instruction: What is the acronym for atrial fibrillation?

Output: AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for atrial fibrillation?. ### Response: AF.


Instruction: What is MI?

Output: myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is MI?. ### Response: myocardial infarction.


Instruction: What is SCD?

Output: sudden cardiac death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SCD?. ### Response: sudden cardiac death.


Instruction: When was the ACCF/AHA Heart Failure Guidelines: Executive Summary published?

Output: 04/17/2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the ACCF/AHA Heart Failure Guidelines: Executive Summary published?. ### Response: 04/17/2014.


Instruction: How many pharmacies are in a limited geographic area?

Output: 144

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many pharmacies are in a limited geographic area?. ### Response: 144.


Instruction: What could potentially have negative im-plications for adherence?

Output: variability in pricing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could potentially have negative im-plications for adherence?. ### Response: variability in pricing.


Instruction: The use of multiple pharmacies prevents theefficiencies of what?

Output: having a single pharmacist overseeing all ofap a t i e n t ’s medications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The use of multiple pharmacies prevents theefficiencies of what?. ### Response: having a single pharmacist overseeing all ofap a t i e n t ’s medications.


Instruction: What prevents theefficiencies of having a single pharmacist overseeing all ofap a t i e n t’s medications?

Output: The use of multiple pharmacies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What prevents theefficiencies of having a single pharmacist overseeing all ofap a t i e n t’s medications?. ### Response: The use of multiple pharmacies.


Instruction: What does the use of multiple pharmacies prevent?

Output: theefﬁciencies of having a single pharmacist overseeing all ofap a t i e n t ’s medications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the use of multiple pharmacies prevent?. ### Response: theefﬁciencies of having a single pharmacist overseeing all ofap a t i e n t ’s medications.


Instruction: What should pharmacists, social workers, and patient navigators help identify?

Output: copay assis-tance programs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should pharmacists, social workers, and patient navigators help identify?. ### Response: copay assis-tance programs.


Instruction: What should patients and clinicians becouraged to do to help identify copay assis-tance programs?

Output: work with pharmacists, social workers,and/or patient navigators to help identify copay assis-tance programs and request price matching

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients and clinicians becouraged to do to help identify copay assis-tance programs?. ### Response: work with pharmacists, social workers,and/or patient navigators to help identify copay assis-tance programs and request price matching.


Instruction: What can be used to assist patients in finding retailers with the lowest cost medications?

Output: price-checkertools

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be used to assist patients in finding retailers with the lowest cost medications?. ### Response: price-checkertools.


Instruction: What are newer HFrEF therapies often expensive, with higher monthly costs andcopays?

Output: Medication Access Measures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are newer HFrEF therapies often expensive, with higher monthly costs andcopays?. ### Response: Medication Access Measures.


Instruction: What kind of authorization is often required before medications are covered?

Output: prior authorization frompayers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What kind of authorization is often required before medications are covered?. ### Response: prior authorization frompayers.


Instruction: What can serve as a signi ficant barrier to coverage?

Output: prior authorization frompayers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can serve as a signi ficant barrier to coverage?. ### Response: prior authorization frompayers.


Instruction: What did the reform of prior authorization and utilization management require?

Output: increase clinical workload and limit patient access to care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the reform of prior authorization and utilization management require?. ### Response: increase clinical workload and limit patient access to care.


Instruction: What does the reform increase clinical workload and limit patient access to care?

Output: prior authorizationprocess and utilization management requirements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the reform increase clinical workload and limit patient access to care?. ### Response: prior authorizationprocess and utilization management requirements.


Instruction: What is important to consider to justify out-of-pocket costs?

Output: the cost-effectiveness of anynew therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is important to consider to justify out-of-pocket costs?. ### Response: the cost-effectiveness of anynew therapy.


Instruction: What did cost-effectiveness analyses of sacubitril and ivabra-dine show?

Output: an incremental cost-effectiveness ratio

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did cost-effectiveness analyses of sacubitril and ivabra-dine show?. ### Response: an incremental cost-effectiveness ratio.


Instruction: What was the cost-effectiveness ratio of CV therapies when they were first adopted or approved?

Output: incremental cost-effectiveness ratio thatcompares favorably to other accepted CV therapies whenthey were ﬁrst adopted or approved ( 146–148

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the cost-effectiveness ratio of CV therapies when they were first adopted or approved?. ### Response: incremental cost-effectiveness ratio thatcompares favorably to other accepted CV therapies whenthey were ﬁrst adopted or approved ( 146–148.


Instruction: Who can help navigate insurance coverage and patientassistance programs to make sure that patients have ac-cess to the appropriate medications?

Output: Pharma-cists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who can help navigate insurance coverage and patientassistance programs to make sure that patients have ac-cess to the appropriate medications?. ### Response: Pharma-cists.


Instruction: What is the standard requests for 90-daysupplies?

Output: 3 re ﬁlls to provide coverage for 1 year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the standard requests for 90-daysupplies?. ### Response: 3 re ﬁlls to provide coverage for 1 year.


Instruction: How long are standard requests for patient assistance?

Output: 90-days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long are standard requests for patient assistance?. ### Response: 90-days.


Instruction: How many re fills are required to provide coverage for 1 year?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many re fills are required to provide coverage for 1 year?. ### Response: 3.


Instruction: What are two of the most challenging aspects of patient assistance programs for patients and clinicians?

Output: income veri ﬁcation and reordering procedures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are two of the most challenging aspects of patient assistance programs for patients and clinicians?. ### Response: income veri ﬁcation and reordering procedures.


Instruction: Many pharmaceutical companies accept signed letters from what?

Output: clinicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Many pharmaceutical companies accept signed letters from what?. ### Response: clinicians.


Instruction: What does a company accept that a patient has no known in-come?

Output: signed letters

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does a company accept that a patient has no known in-come?. ### Response: signed letters.


Instruction: What can be used to replace ficial income docu-nt?

Output: signed letters

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be used to replace ficial income docu-nt?. ### Response: signed letters.


Instruction: What does nonpharmacological treatment consist of?

Output: nutrition

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does nonpharmacological treatment consist of?. ### Response: nutrition.


Instruction: What is the primary prevention of psychosocial deprivation?

Output: public health

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary prevention of psychosocial deprivation?. ### Response: public health.


Instruction: What is another term for secondhand smoke?

Output: smoking

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for secondhand smoke?. ### Response: smoking.


Instruction: What is a term for smoking cessation?

Output: statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a term for smoking cessation?. ### Response: statin therapy.


Instruction: What is type 2 diabetes mellitus?

Output: waist circumference

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is type 2 diabetes mellitus?. ### Response: waist circumference.


Instruction: When was this article published?

Output: May 1, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this article published?. ### Response: May 1, 2023.


Instruction: What is ahajournals.org about?

Output: http://ahajournals.org by on May 1, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ahajournals.org about?. ### Response: http://ahajournals.org by on May 1, 2023.


Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020 Page 2 of 127

Output: The Management of Dyslipidemia for Cardiovascular Risk Reduction  Work Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020 Page 2 of 127. ### Response: The Management of Dyslipidemia for Cardiovascular Risk Reduction  Work Group.