Instruction: How is warfarin compared to other anticoagulants?

Output: efficacy and safety

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is warfarin compared to other anticoagulants?. ### Response: efficacy and safety.


Instruction: How many wkProsthetic valve Staphylococci are resistant to oxacillin?

Output: 6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many wkProsthetic valve Staphylococci are resistant to oxacillin?. ### Response: 6.


Instruction: Native or prosthetic valve enterococcus treated with what antibiotic?

Output: vancomycin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Native or prosthetic valve enterococcus treated with what antibiotic?. ### Response: vancomycin.


Instruction: How many wkHACEK indicates Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species?

Output: 6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many wkHACEK indicates Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species?. ### Response: 6.


Instruction: Patients with complicated episodes or recurrences may require what?

Output: additional treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with complicated episodes or recurrences may require what?. ### Response: additional treatment.


Instruction: How long is recommended for some adult patients?

Output: Two weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is recommended for some adult patients?. ### Response: Two weeks.


Instruction: What is not recommended for children because of lack of effectiveness data?

Output: Two weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended for children because of lack of effectiveness data?. ### Response: Two weeks.


Instruction: IOM Standards for Systematic Reviews Part of the KDIGO Process?

Output: 2.6.10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: IOM Standards for Systematic Reviews Part of the KDIGO Process?. ### Response: 2.6.10.


Instruction: What does 2.6.10 describe and justify any planned analyses of differential treatment effects according to patient subgroups?

Output: IOM Standards for Systematic Reviews

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does 2.6.10 describe and justify any planned analyses of differential treatment effects according to patient subgroups?. ### Response: IOM Standards for Systematic Reviews.


Instruction: What is the timetable for conducting the review?

Output: 2.7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the timetable for conducting the review?. ### Response: 2.7.


Instruction: Submit the protocol for peer review No 2.7.1 Provide a public comment period for the protoc ol and publicly report on disposition of comments No 2.8 Make the final protocol publicly available and add any amendments to the protocol in a timely fashion?

Output: Describe the proposed timetable for conducting the review Yes 2.7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Submit the protocol for peer review No 2.7.1 Provide a public comment period for the protoc ol and publicly report on disposition of comments No 2.8 Make the final protocol publicly available and add any amendments to the protocol in a timely fashion?. ### Response: Describe the proposed timetable for conducting the review Yes 2.7.


Instruction: How do you add amendments to the protocol in a timely fashion?

Output: Make the final protocol publicly available

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do you add amendments to the protocol in a timely fashion?. ### Response: Make the final protocol publicly available.


Instruction: What type of search does a librarian or other information specia list trained in performing systematic reviews do?

Output: to plan the search strategy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of search does a librarian or other information specia list trained in performing systematic reviews do?. ### Response: to plan the search strategy.


Instruction: How does the search strategy address each key issue?

Output: Design

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does the search strategy address each key issue?. ### Response: Design.


Instruction: What type of librarian or other information specialist can peer review the search strategy?

Output: independent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of librarian or other information specialist can peer review the search strategy?. ### Response: independent.


Instruction: Search bibliographic databases Yes 3.1.5 Search citation indexes Yes 3.1.6 Search literature cited by eligible studies Yes 3.1.7 Search literature cit ed by what studies?

Output: eligible studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Search bibliographic databases Yes 3.1.5 Search citation indexes Yes 3.1.6 Search literature cited by eligible studies Yes 3.1.7 Search literature cit ed by what studies?. ### Response: eligible studies.


Instruction: 3.1.6 Search literature cit ed by eligible studies No 3.1.7 Update the search at intervals appropriate to the pace of generation of new information for the research question being addressed Yes 3.1.8 Search subject-specific databases if other databas es are unlikely to provide all relevant evidence N/A 3.1.9 Search regional databases?

Output: Search bibliographic databases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: 3.1.6 Search literature cit ed by eligible studies No 3.1.7 Update the search at intervals appropriate to the pace of generation of new information for the research question being addressed Yes 3.1.8 Search subject-specific databases if other databas es are unlikely to provide all relevant evidence N/A 3.1.9 Search regional databases?. ### Response: Search bibliographic databases.


Instruction: What do you do if other databases are unlikely to provide all relevant evidence N/A 3.1.9 Search regional bibliographic databases?

Output: Search subject-specific databases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do you do if other databases are unlikely to provide all relevant evidence N/A 3.1.9 Search regional bibliographic databases?. ### Response: Search subject-specific databases.


Instruction: Take action to address potentially biased reporting of research results No 3.2.1 Search grey-literature databases, clinical trial registries and other sources of what?

Output: unpublished information about studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Take action to address potentially biased reporting of research results No 3.2.1 Search grey-literature databases, clinical trial registries and other sources of what?. ### Response: unpublished information about studies.


Instruction: What should researchers clarify about study eligibility, study characteristics, and risk of bias?

Output: Invite researchers to clarify information

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should researchers clarify about study eligibility, study characteristics, and risk of bias?. ### Response: Invite researchers to clarify information.


Instruction: What should all study sponsors and researchers submit for possible inclusion in the systematic review?

Output: unpublished data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should all study sponsors and researchers submit for possible inclusion in the systematic review?. ### Response: unpublished data.


Instruction: What is included in a systematic review?

Output: unreported outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is included in a systematic review?. ### Response: unreported outcomes.


Instruction: What is a possible inclusion in the systematic review No 3.2.4 Handsearch selected journal s and conference abstracts No 3.2.5 Conduct a web search No 3.2.6 Search for studies reported in languages other than English if appropriate?

Output: Invite all study sponsors and researchers to submit unpublished data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a possible inclusion in the systematic review No 3.2.4 Handsearch selected journal s and conference abstracts No 3.2.5 Conduct a web search No 3.2.6 Search for studies reported in languages other than English if appropriate?. ### Response: Invite all study sponsors and researchers to submit unpublished data.


Instruction: How many members of a review team can work independently?

Output: two or more

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many members of a review team can work independently?. ### Response: two or more.


Instruction: What type of studies can be used to evaluate harms of interventions?

Output: observational studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of studies can be used to evaluate harms of interventions?. ### Response: observational studies.


Instruction: How many members of the review team work independently to screen and select studies?

Output: two or more

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many members of the review team work independently to screen and select studies?. ### Response: two or more.


Instruction: How do screeners train screeners?

Output: using written documentation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do screeners train screeners?. ### Response: using written documentation.


Instruction: What does screeners do to improve accuracy and consistency?

Output: test and retest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does screeners do to improve accuracy and consistency?. ### Response: test and retest.


Instruction: How many fulltext articles were identified in the search?

Output: all

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many fulltext articles were identified in the search?. ### Response: all.


Instruction: How many screen titles and abstracts of all articles were found in the initial screening?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many screen titles and abstracts of all articles were found in the initial screening?. ### Response: 2.


Instruction: What is the risk of bias?

Output: study eligibility, study characteristics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of bias?. ### Response: study eligibility, study characteristics.


Instruction: What type of studies can be used to address gaps in the data?

Output: observational

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of studies can be used to address gaps in the data?. ### Response: observational.


Instruction: Who wrote the 2019 Guidelines for Management of AIS e413Atrial Fibrillation Trial?

Output: Powers et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote the 2019 Guidelines for Management of AIS e413Atrial Fibrillation Trial?. ### Response: Powers et al.


Instruction: What year did Powers and colleagues publish the guidelines?

Output: 2019

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Powers and colleagues publish the guidelines?. ### Response: 2019.


Instruction: What is Find-AFrandomised?

Output: an open-label randomised controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Find-AFrandomised?. ### Response: an open-label randomised controlled trial.


Instruction: What is the name of the open-label randomised controlled trial?

Output: Holter-electrocardiogram-monitoring in patients with acute ischaemic stroke (Find-AFrandomised

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the open-label randomised controlled trial?. ### Response: Holter-electrocardiogram-monitoring in patients with acute ischaemic stroke (Find-AFrandomised.


Instruction: What is a randomized trial of atrial arrhythmia monitoring to guide anticoagula-tion in patients with implanted defibrillator and cardiac resynchronization devices?

Output: IMPACT Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a randomized trial of atrial arrhythmia monitoring to guide anticoagula-tion in patients with implanted defibrillator and cardiac resynchronization devices?. ### Response: IMPACT Investigators.


Instruction: What does Eur Heart J. 2015:36:1660-1668?

Output: patients with implanted defibrillator and cardiac resynchronization devices

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Eur Heart J. 2015:36:1660-1668?. ### Response: patients with implanted defibrillator and cardiac resynchronization devices.


Instruction: What is atrial fibrillation in patients with cryptogenic stroke?

Output: Transesophageal echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is atrial fibrillation in patients with cryptogenic stroke?. ### Response: Transesophageal echocardiography.


Instruction: What does N Engl J Med. 2014:370:2467-2477?

Output: Atrial fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does N Engl J Med. 2014:370:2467-2477?. ### Response: Atrial fibrillation.


Instruction: What is the predictive value of newly detected atrial fibrillation paroxysms in patients with acute ischemic stroke?

Output: atrial fibrillation after 90 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the predictive value of newly detected atrial fibrillation paroxysms in patients with acute ischemic stroke?. ### Response: atrial fibrillation after 90 days.


Instruction: How long does it take for atrial fibrosis to be detected?

Output: 90 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take for atrial fibrosis to be detected?. ### Response: 90 days.


Instruction: What is TARDIS?

Output: acute cerebral ischaemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is TARDIS?. ### Response: acute cerebral ischaemia.


Instruction: What is the difference between aspirin, clopidogrel, and di-pyridamole in patients with acute cerebral ischaemia?

Output: Antiplatelet therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between aspirin, clopidogrel, and di-pyridamole in patients with acute cerebral ischaemia?. ### Response: Antiplatelet therapy.


Instruction: When was the phase 3 superiority trial conducted?

Output: 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the phase 3 superiority trial conducted?. ### Response: 2018.


Instruction: What is the name of the open-label, phase 3 superiority trial?

Output: TARDIS Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the open-label, phase 3 superiority trial?. ### Response: TARDIS Investigators.


Instruction: When did the Lancet publish the results of the study?

Output: 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Lancet publish the results of the study?. ### Response: 2018.


Instruction: What is one of the benefits of echocardiography and carotid im-aging in stroke management?

Output: Effectiveness and cost-effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the benefits of echocardiography and carotid im-aging in stroke management?. ### Response: Effectiveness and cost-effectiveness.


Instruction: What is the need for inpatient echocardiography?

Output: acute ischaemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the need for inpatient echocardiography?. ### Response: acute ischaemic stroke.


Instruction: Acute ischaemic stroke or transient ischaemia and need for what?

Output: inpatient echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Acute ischaemic stroke or transient ischaemia and need for what?. ### Response: inpatient echocardiography.


Instruction: Med J. 2014;90:434–438. doi: 10.136/postgradmedj-2013-132220 353. Holmes M, Rathbone J, Littlewood C, Rawdin A, Stevenson M, Stevens J, Archer R, Evans P, Wang J. Routine echocardiography in the management of stroke and transient ischaemic attack: a systematic re-view and what?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Med J. 2014;90:434–438. doi: 10.136/postgradmedj-2013-132220 353. Holmes M, Rathbone J, Littlewood C, Rawdin A, Stevenson M, Stevens J, Archer R, Evans P, Wang J. Routine echocardiography in the management of stroke and transient ischaemic attack: a systematic re-view and what?. ### Response: stroke.


Instruction: Health Technol Assess. 2014.;18:1–176

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Health Technol Assess. 2014.;18:1–176. ### Response: stroke.


Instruction: What is the name of the systematic review of echocardiography in patients with cryp-togenic ischemic stroke?

Output: Am Heart J.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review of echocardiography in patients with cryp-togenic ischemic stroke?. ### Response: Am Heart J..


Instruction: What are the names of the authors of this systematic review?

Output: McGrath ER, Paikin JS, Motlagh B, Salehian O, Kapral MK, O’Donnell MJ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the authors of this systematic review?. ### Response: McGrath ER, Paikin JS, Motlagh B, Salehian O, Kapral MK, O’Donnell MJ.


Instruction: What is the name of the randomized clinical trial that compares double kissing crush with provisional stenting for treatment of coronary bifurcation lesions?

Output: DKCRUSH-II

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized clinical trial that compares double kissing crush with provisional stenting for treatment of coronary bifurcation lesions?. ### Response: DKCRUSH-II.


Instruction: What does DKCRUSH-II stand for?

Output: doublekissing crush versus provisional stenting technique for treatment ofcoronary bifurcation lesions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does DKCRUSH-II stand for?. ### Response: doublekissing crush versus provisional stenting technique for treatment ofcoronary bifurcation lesions.


Instruction: When was the J Am Coll Cardiol 57:914–20.731 published?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol 57:914–20.731 published?. ### Response: 2011.


Instruction: What is the difference between randomized clinical trials and patient centered decision-making?

Output: disconnect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between randomized clinical trials and patient centered decision-making?. ### Response: disconnect.


Instruction: When was this article published?

Output: May 1, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this article published?. ### Response: May 1, 2023.


Instruction: Where can this article be found?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can this article be found?. ### Response: http://ahajournals.org.


Instruction: What are members of the writing panel required to complete and submit?

Output: a Disclosure Questionnaire

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are members of the writing panel required to complete and submit?. ### Response: a Disclosure Questionnaire.


Instruction: What is a Disclosure Questionnaire?

Output: showing all such relationships that might be perceived as real or potential conflicts of interest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a Disclosure Questionnaire?. ### Response: showing all such relationships that might be perceived as real or potential conflicts of interest.


Instruction: Who requests the disclosure questionnaire?

Output: The American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who requests the disclosure questionnaire?. ### Response: The American Heart Association.


Instruction: Who requested that this document be cited?

Output: The American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who requested that this document be cited?. ### Response: The American Heart Association.


Instruction: What is the name of the organization that requested this document?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that requested this document?. ### Response: American Heart Association.


Instruction: Who is on behalf of the American Heart Association StrokeCouncil?

Output: Connolly ES Jr, Rabinstein AA, Carhuapoma JR, Derdeyn CP, DionJ, Higashida RT, Hoh BL, Kirkness CJ, Naidech AM, Ogilvy CS, Patel AB, Thompson BG, Vespa P

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is on behalf of the American Heart Association StrokeCouncil?. ### Response: Connolly ES Jr, Rabinstein AA, Carhuapoma JR, Derdeyn CP, DionJ, Higashida RT, Hoh BL, Kirkness CJ, Naidech AM, Ogilvy CS, Patel AB, Thompson BG, Vespa P.


Instruction: What are the guidelines for the management of aneurysmal subarachnoid hemorrhage?

Output: a guideline for healthcare professional

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the guidelines for the management of aneurysmal subarachnoid hemorrhage?. ### Response: a guideline for healthcare professional.


Instruction: Who conducts expert peer review of AHA Scientific Statements?

Output: AHA Office of Science Operations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who conducts expert peer review of AHA Scientific Statements?. ### Response: AHA Office of Science Operations.


Instruction: Where can you find more information on AHA statements and guidelines?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find more information on AHA statements and guidelines?. ### Response: http://my.americanheart.org/statements.


Instruction: What is a link to the "Copyright Permissions Request Form" located on the right side of the page?

Output: pag e

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a link to the "Copyright Permissions Request Form" located on the right side of the page?. ### Response: pag e.


Instruction: What is the name of the organization that grants permission for multiple copies of this document?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that grants permission for multiple copies of this document?. ### Response: American Heart Association.


Instruction: What appears on the right side of the pag e?

Output: A link to the “Copyright Permissions Request Form

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What appears on the right side of the pag e?. ### Response: A link to the “Copyright Permissions Request Form.


Instruction: When was the statement approved by the American Heart Association Science Advisory and Coordinating Committee?

Output: January 30, 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the statement approved by the American Heart Association Science Advisory and Coordinating Committee?. ### Response: January 30, 2012.


Instruction: Where can a copy of the statement be found?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can a copy of the statement be found?. ### Response: http://my.americanheart.org/statements.


Instruction: What is the name of the 2012 American Heart Association, Inc. Stroke is available at http://stroke.ahajournals.org DOI: 10.1161/STR.0b013e31825878391711Downloaded by on what date?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2012 American Heart Association, Inc. Stroke is available at http://stroke.ahajournals.org DOI: 10.1161/STR.0b013e31825878391711Downloaded by on what date?. ### Response: April 28, 2023.


Instruction: What was the HR of the composite of primary CVdisease outcome or all-cause death?

Output: 0.66

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the HR of the composite of primary CVdisease outcome or all-cause death?. ### Response: 0.66.


Instruction: What was there no description of potential harm of achieving lower targets in this subgroup of older adults withCKD?

Output: 91

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was there no description of potential harm of achieving lower targets in this subgroup of older adults withCKD?. ### Response: 91.


Instruction: What was the benefit ratio in the whole CKDcohort and in the entire subcohort older than 75 years inSPRINT?

Output: 0.64

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the benefit ratio in the whole CKDcohort and in the entire subcohort older than 75 years inSPRINT?. ### Response: 0.64.


Instruction: In the age group 80 years and older, what decreased the risk of CV events?

Output: intensive BPlowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the age group 80 years and older, what decreased the risk of CV events?. ### Response: intensive BPlowering.


Instruction: What is the risk factor for all-cause mortality?

Output: HR: 0.67

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk factor for all-cause mortality?. ### Response: HR: 0.67.


Instruction: What are the risk factors for adults with diabetes and CKD?

Output: mortality and kidney outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the risk factors for adults with diabetes and CKD?. ### Response: mortality and kidney outcomes.


Instruction: Are the benefits of intensive BPlowering more or less certain?

Output: less

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Are the benefits of intensive BPlowering more or less certain?. ### Response: less.


Instruction: What type of studies have favored more rather than less intensive BP reduction?

Output: All previous studies in diabetes with and without CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of studies have favored more rather than less intensive BP reduction?. ### Response: All previous studies in diabetes with and without CKD.


Instruction: What did Ettehad et al. report that the reduction in major CV events remained proportional to?

Output: the BP reduc-tion achieved among trial participants with diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Ettehad et al. report that the reduction in major CV events remained proportional to?. ### Response: the BP reduc-tion achieved among trial participants with diabetes.


Instruction: What proportional risk reductions were smaller than the re-ductions in those without diabetes?

Output: reductionin major CV events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What proportional risk reductions were smaller than the re-ductions in those without diabetes?. ### Response: reductionin major CV events.


Instruction: In themeta-analysis of intensive versus less-intensive BP-loweringtherapy among patients with CKD, Malhotra et al. found no evidence of heterogeneity in beneficial effects on mortality?

Output: diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In themeta-analysis of intensive versus less-intensive BP-loweringtherapy among patients with CKD, Malhotra et al. found no evidence of heterogeneity in beneficial effects on mortality?. ### Response: diabetes.


Instruction: Who conducted a systematic review and meta-analysis of RCTs that included at least 100 patients with diabetes?

Output: Brunström et al.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who conducted a systematic review and meta-analysis of RCTs that included at least 100 patients with diabetes?. ### Response: Brunström et al..


Instruction: What decreased MI, stroke,CV mortality, ESKD, and all-cause mortality if baseline SBPwas>150mm Hg?

Output: BP reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What decreased MI, stroke,CV mortality, ESKD, and all-cause mortality if baseline SBPwas>150mm Hg?. ### Response: BP reduction.


Instruction: What was decreased if baseline SBP was 140 to 150 mm Hg?

Output: MI, HF, and all-causemortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was decreased if baseline SBP was 140 to 150 mm Hg?. ### Response: MI, HF, and all-causemortality.


Instruction: What was increased when baselineSBP was 140 mmHg? What are the two major caveats regarding these meta-analyses in diabetes?

Output: these meta-analyses differ sub-stantially from each other in their respective inclusioncriteria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was increased when baselineSBP was 140 mmHg? What are the two major caveats regarding these meta-analyses in diabetes?. ### Response: these meta-analyses differ sub-stantially from each other in their respective inclusioncriteria.


Instruction: What did Brunström and Ettehad compare antihypertensives to?

Output: placebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Brunström and Ettehad compare antihypertensives to?. ### Response: placebo.


Instruction: What was the effect of 10mm Hg reduction in SBP on SBP?

Output: clinical outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the effect of 10mm Hg reduction in SBP on SBP?. ### Response: clinical outcomes.


Instruction: How many meta-analyses differ from each other?

Output: sub-stantially

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many meta-analyses differ from each other?. ### Response: sub-stantially.


Instruction: What is the effect of 10mm Hg reduction in SBP on clinical outcomes?

Output: decreases the CVevent rate and perhaps mortality and kidney outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of 10mm Hg reduction in SBP on clinical outcomes?. ### Response: decreases the CVevent rate and perhaps mortality and kidney outcomes.


Instruction: None of the trials conducted prior to ACCORD and SPRINTexamined an SBP target as low as what?

Output: <120 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: None of the trials conducted prior to ACCORD and SPRINTexamined an SBP target as low as what?. ### Response: <120 mm Hg.


Instruction: What was the prespeci fid primaryendpoint of composite CV events?

Output: all-cause death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the prespeci fid primaryendpoint of composite CV events?. ### Response: all-cause death.


Instruction: What did the ACCORD trial not show?

Output: a difference in the prespeci ﬁed primaryendpoint of composite CV events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the ACCORD trial not show?. ### Response: a difference in the prespeci ﬁed primaryendpoint of composite CV events.


Instruction: The intensive SBPtarget showed a difference in what?

Output: decreased the risk of CV events (HR: 0.66; 95% CI:0.49–0.90) and all-cause mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The intensive SBPtarget showed a difference in what?. ### Response: decreased the risk of CV events (HR: 0.66; 95% CI:0.49–0.90) and all-cause mortality.


Instruction: What did the study show?

Output: decreased the risk of CV events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the study show?. ### Response: decreased the risk of CV events.


Instruction: What was the HR of the study?

Output: 0.59

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the HR of the study?. ### Response: 0.59.


Instruction: How was the SBP lowered?

Output: intensive SBP lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the SBP lowered?. ### Response: intensive SBP lowering.


Instruction: What is the focus of the 2017 ACC/AHA/HFSA Heart Failure Focused UpdateCirculation. 2017;136:e137–e161?

Output: clinical practice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the focus of the 2017 ACC/AHA/HFSA Heart Failure Focused UpdateCirculation. 2017;136:e137–e161?. ### Response: clinical practice.


Instruction: What does the Task Force strive to avoid?

Output: bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Task Force strive to avoid?. ### Response: bias.


Instruction: What types of backgrounds do writing commit-tee members represent?

Output: different geographic regions, sexes, ethnicities, races, intellectual perspectives/biases, and scopes of clinical practice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What types of backgrounds do writing commit-tee members represent?. ### Response: different geographic regions, sexes, ethnicities, races, intellectual perspectives/biases, and scopes of clinical practice.


Instruction: Who may also invite organizations and professional societies to participate as partners, collaborators, or endorsers?

Output: The Task Force

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who may also invite organizations and professional societies to participate as partners, collaborators, or endorsers?. ### Response: The Task Force.


Instruction: What do ACC and AHA have to ensure that guidelines are developed without bias or improper influence?

Output: rigorous policies and meth-ods

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do ACC and AHA have to ensure that guidelines are developed without bias or improper influence?. ### Response: rigorous policies and meth-ods.


Instruction: What can the complete relationships with industry and other entities (RWI) policy be found online?

Output: Appendix 1 of the current document lists writing committee members’ relevant RWI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can the complete relationships with industry and other entities (RWI) policy be found online?. ### Response: Appendix 1 of the current document lists writing committee members’ relevant RWI.


Instruction: What does Appendix 1 of the current document list?

Output: writing committee members’ relevant RWI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Appendix 1 of the current document list?. ### Response: writing committee members’ relevant RWI.


Instruction: What is available online for the purposes of full transparency?

Output: writing committee mem-bers’ comprehensive disclosure information

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is available online for the purposes of full transparency?. ### Response: writing committee mem-bers’ comprehensive disclosure information.


Instruction: Where is comprehensive disclosure information for the Task Force?

Output: online

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is comprehensive disclosure information for the Task Force?. ### Response: online.


Instruction: What does the writing com-mittee use when developing recommendations?

Output: evidence-based methodologies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the writing com-mittee use when developing recommendations?. ### Response: evidence-based methodologies.


Instruction: What do literature searches focus on?

Output: randomized controlled trials (RCTs)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do literature searches focus on?. ### Response: randomized controlled trials (RCTs).


Instruction: How many questions are deemed of utmost clinical importance that merit formal systematic review?

Output: 1 or more

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many questions are deemed of utmost clinical importance that merit formal systematic review?. ### Response: 1 or more.


Instruction: What is an independent evidence review committee called?

Output: ERC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an independent evidence review committee called?. ### Response: ERC.


Instruction: What will strive to de-termine which patients are most likely to benefit from a drug, device, or treatment strategy?

Output: An independent evidence review committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will strive to de-termine which patients are most likely to benefit from a drug, device, or treatment strategy?. ### Response: An independent evidence review committee.


Instruction: What criteria for commissioning an ERC and formal systematic review include: a) the absence of a current authoritative systematic review; b) the feasibility of defining what?

Output: the ben-efit and risk in a time frame consistent with the writing of a guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What criteria for commissioning an ERC and formal systematic review include: a) the absence of a current authoritative systematic review; b) the feasibility of defining what?. ### Response: the ben-efit and risk in a time frame consistent with the writing of a guideline.


Instruction: What are ERC members?

Output: methodologists, epidemiologists, healthcare providers, and biostatisticians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are ERC members?. ### Response: methodologists, epidemiologists, healthcare providers, and biostatisticians.


Instruction: What is the likelihood that the findings can be translated into actionable recommendations?

Output: d

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the likelihood that the findings can be translated into actionable recommendations?. ### Response: d.


Instruction: What is the term for guideline-directed management and therapy?

Output: GDMT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for guideline-directed management and therapy?. ### Response: GDMT.


Instruction: What does GDMT mean?

Output: guideline-directed management and therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does GDMT mean?. ### Response: guideline-directed management and therapy.


Instruction: What is GDMT?

Output: guideline-directed management and therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is GDMT?. ### Response: guideline-directed management and therapy.


Instruction: How many hemorrhagic strokes did patients receiving the device have than those receiving warfarin?

Output: significantly fewer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many hemorrhagic strokes did patients receiving the device have than those receiving warfarin?. ### Response: significantly fewer.


Instruction: What was the difference in ischemic strokes when periprocedural events were excluded?

Output: not significant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the difference in ischemic strokes when periprocedural events were excluded?. ### Response: not significant.


Instruction: What was not significant when events were excluded?

Output: the dif-ference in ischemic strokes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not significant when events were excluded?. ### Response: the dif-ference in ischemic strokes.


Instruction: What remains the preferred ther-apy for stroke prevention for most patients with AF and elevated stroke risk?

Output: Oral anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What remains the preferred ther-apy for stroke prevention for most patients with AF and elevated stroke risk?. ### Response: Oral anticoagulation.


Instruction: What is another name for the Watchman device?

Output: oral anticoagu-lation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for the Watchman device?. ### Response: oral anticoagu-lation.


Instruction: What is the difference between the FDA approval and the CMS approval?

Output: wording

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between the FDA approval and the CMS approval?. ### Response: wording.


Instruction: Who approved the device?

Output: FDA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who approved the device?. ### Response: FDA.


Instruction: What was the device restricted to?

Output: patients who were deemed suitable for long-term warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the device restricted to?. ### Response: patients who were deemed suitable for long-term warfarin.


Instruction: Who states that the device is an option for patients who are deemed suitable for long term warfarin?

Output: FDA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who states that the device is an option for patients who are deemed suitable for long term warfarin?. ### Response: FDA.


Instruction: What are patients who are suitable for short-term warfarin deemed unable to take long-term oral anticoagulation?

Output: patients who are suitable for short-term warfarin but deemed unable to take long-term oral anticoagulation. CMS has specified that patients should have a CHADS2 score ≥2 or a CHA2DS2-VASc score ≥3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients who are suitable for short-term warfarin deemed unable to take long-term oral anticoagulation?. ### Response: patients who are suitable for short-term warfarin but deemed unable to take long-term oral anticoagulation. CMS has specified that patients should have a CHADS2 score ≥2 or a CHA2DS2-VASc score ≥3.


Instruction: What should patients have to have a CHADS2 score 2 or CHA2DS2-VASc score?

Output: ≥3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients have to have a CHADS2 score 2 or CHA2DS2-VASc score?. ### Response: ≥3.


Instruction: What are two issues that remain unresolved?

Output: optimal patient selection and peripro-cedural antithrombotic regimen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are two issues that remain unresolved?. ### Response: optimal patient selection and peripro-cedural antithrombotic regimen.


Instruction: What does the current FDA labeling specify?

Output: patients should be deemed suitable for anticoagulation and, in particular, a period of periprocedural anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the current FDA labeling specify?. ### Response: patients should be deemed suitable for anticoagulation and, in particular, a period of periprocedural anticoagulation.


Instruction: Patients unable to take oral anticoagulation were excluded from what?

Output: Watchman RCTs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients unable to take oral anticoagulation were excluded from what?. ### Response: Watchman RCTs.


Instruction: Who was excluded from the Watchman RCTs?

Output: Patients unable to take oral anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was excluded from the Watchman RCTs?. ### Response: Patients unable to take oral anticoagulation.


Instruction: What is in-creasing experience outside the US with LAA closure in oral anticoagulation?

Output: –ineligible pa-tients using an antiplatelet regimen only

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is in-creasing experience outside the US with LAA closure in oral anticoagulation?. ### Response: –ineligible pa-tients using an antiplatelet regimen only.


Instruction: Where does this guideline place CG127?

Output: NG28

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where does this guideline place CG127?. ### Response: NG28.


Instruction: What is the basis of QS181, QS28 and QS209?

Output: CG127 . This guideline par tially r eplaces NG28 . This guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the basis of QS181, QS28 and QS209?. ### Response: CG127 . This guideline par tially r eplaces NG28 . This guideline.


Instruction: How is hyper tension defined in people aged 18?

Output: high blood pr essur e

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is hyper tension defined in people aged 18?. ### Response: high blood pr essur e.


Instruction: What is high blood pressure in people aged 18 and over?

Output: hyper tension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is high blood pressure in people aged 18 and over?. ### Response: hyper tension.


Instruction: What is it aimed to reduce t he risk of car diovascular pr oblems such as heart attacks and str okes?

Output: helping healt hcare professionals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is it aimed to reduce t he risk of car diovascular pr oblems such as heart attacks and str okes?. ### Response: helping healt hcare professionals.


Instruction: What is NICE's guideline on h yper tension in pr egnancy?

Output: Healt hcare professionals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE's guideline on h yper tension in pr egnancy?. ### Response: Healt hcare professionals.


Instruction: What does NICE help healt hcare professionals do?

Output: diagnose h yper tension accurat ely and tr eat it eff ectiv ely

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does NICE help healt hcare professionals do?. ### Response: diagnose h yper tension accurat ely and tr eat it eff ectiv ely.


Instruction: Who are high blood pressure patients referred to as?

Output: People who ha ve or ma y

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who are high blood pressure patients referred to as?. ### Response: People who ha ve or ma y.


Instruction: What is the name of the book called Hyper tension in adult s?

Output: NG136

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the book called Hyper tension in adult s?. ### Response: NG136.


Instruction: What is NICE 2023?

Output: People who ha ve or ma y have high blood pr essur e, their f amilies and car ers Hyper tension in adult s: diagnosis and management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE 2023?. ### Response: People who ha ve or ma y have high blood pr essur e, their f amilies and car ers Hyper tension in adult s: diagnosis and management.


Instruction: What is the last updat ed 18 Mar 2022?

Output: Page 5of 51

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the last updat ed 18 Mar 2022?. ### Response: Page 5of 51.


Instruction: What is recovered uncommonly from patients with bacteremia?

Output: high penicillin resistance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recovered uncommonly from patients with bacteremia?. ### Response: high penicillin resistance.


Instruction: What is increasing in frequency with cross-resistance of pneumococci to other antimicrobial agents?

Output: cephalosporins, mac-rolides, fluoroquinolones, carbapenems, and even vanco-mycin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is increasing in frequency with cross-resistance of pneumococci to other antimicrobial agents?. ### Response: cephalosporins, mac-rolides, fluoroquinolones, carbapenems, and even vanco-mycin.


Instruction: How many multicenter studies were conducted?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many multicenter studies were conducted?. ### Response: 1.


Instruction: How many patients had IE caused by Table 8?

Output: 131

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had IE caused by Table 8?. ### Response: 131.


Instruction: What is the name of the strain of VGS that is resistant to penicillin?

Output: Streptococcus gallolyticus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the strain of VGS that is resistant to penicillin?. ### Response: Streptococcus gallolyticus.


Instruction: What type of penicillin is used to treat IE caused penicillin-resistant VGS strains?

Output: ampicillin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of penicillin is used to treat IE caused penicillin-resistant VGS strains?. ### Response: ampicillin.


Instruction: How many equally divided doses of crystalline penicillin G sodium are available?

Output: 4–6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many equally divided doses of crystalline penicillin G sodium are available?. ### Response: 4–6.


Instruction: What is a reasonable alternative to penicillin if a penicillin shortage exists?

Output: Ampicillin 2 g IV every 4 h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a reasonable alternative to penicillin if a penicillin shortage exists?. ### Response: Ampicillin 2 g IV every 4 h.


Instruction: How many mg/kg per 24 h IV or IM is plusGentamicin sulfate?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mg/kg per 24 h IV or IM is plusGentamicin sulfate?. ### Response: 3.


Instruction: What is a reasonable alternative treatment option for VGS isolates that are susceptible to ceftriaxone (Class IIb; Level of Evidence C)?

Output: Ceftriaxone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a reasonable alternative treatment option for VGS isolates that are susceptible to ceftriaxone (Class IIb; Level of Evidence C)?. ### Response: Ceftriaxone.


Instruction: What is 30 mg/kg per 24 h IV in 2 equally divided doses?

Output: Vancomycin hydrochloride

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is 30 mg/kg per 24 h IV in 2 equally divided doses?. ### Response: Vancomycin hydrochloride.


Instruction: How many equally divided doses of CVancomycin?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many equally divided doses of CVancomycin?. ### Response: 2.


Instruction: What does IE mean?

Output: infective endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does IE mean?. ### Response: infective endocarditis.


Instruction: How does IV refer to the minimum inhibitory concentration?

Output: MIC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does IV refer to the minimum inhibitory concentration?. ### Response: MIC.


Instruction: WHAT does VGS refer to?

Output: viridans group streptococci

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: WHAT does VGS refer to?. ### Response: viridans group streptococci.


Instruction: What is the MIC for penicillin?

Output: >0.12 to <0.5 μg/mL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the MIC for penicillin?. ### Response: >0.12 to <0.5 μg/mL.


Instruction: What are the break points used to define penicillin susceptibility?

Output: Clinical and Laboratory Standards Institute–recommended

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the break points used to define penicillin susceptibility?. ### Response: Clinical and Laboratory Standards Institute–recommended.


Instruction: Patients with normal renal function are recommended what?

Output: Doses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with normal renal function are recommended what?. ### Response: Doses.


Instruction: What is the recommended daily dose of gentamicin?

Output: 3 mg/kg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommended daily dose of gentamicin?. ### Response: 3 mg/kg.


Instruction: How many equally divided doses can be given as a second option?

Output: 4–6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many equally divided doses can be given as a second option?. ### Response: 4–6.


Instruction: What is endocarditis caused by?

Output: viridans group streptococci

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is endocarditis caused by?. ### Response: viridans group streptococci.


Instruction: How many equally divided doses of vancomycin should be given daily?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many equally divided doses of vancomycin should be given daily?. ### Response: 2.


Instruction: What is accurate in hyperacute intracerebral hemorrhage?

Output: Stroke magnetic resonance imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is accurate in hyperacute intracerebral hemorrhage?. ### Response: Stroke magnetic resonance imaging.


Instruction: What is a multicenter study on the accuracy of stroke magnetic resonance imaging?

Output: hyperacute intracerebral hemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a multicenter study on the accuracy of stroke magnetic resonance imaging?. ### Response: hyperacute intracerebral hemorrhage.


Instruction: What is accurate in hyperacute intracerebral hemorrhage: a multicenter study on the validity of stroke imaging?

Output: Stroke magnetic resonance imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is accurate in hyperacute intracerebral hemorrhage: a multicenter study on the validity of stroke imaging?. ### Response: Stroke magnetic resonance imaging.


Instruction: When did Stroke. 2004;35:502-506. doi: 10.1161/01.STR.0000114203.75678.88?

Output: 2005;293:2391–2402. doi: 10.1001/jama.293.19.2391. 41. Fiebach JB, Schellinger PD, Gass A, Kucinski T, Siebler M, Villringer A, Olkers P, Hirsch JG, Heiland S, Wilde P, Jansen O, Röther J, Hacke W, Sartor K; Kompetenznetzwerk Schlaganfall B5. Stroke magnetic resonance imaging is accurate in hyperacute intracerebral hemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Stroke. 2004;35:502-506. doi: 10.1161/01.STR.0000114203.75678.88?. ### Response: 2005;293:2391–2402. doi: 10.1001/jama.293.19.2391. 41. Fiebach JB, Schellinger PD, Gass A, Kucinski T, Siebler M, Villringer A, Olkers P, Hirsch JG, Heiland S, Wilde P, Jansen O, Röther J, Hacke W, Sartor K; Kompetenznetzwerk Schlaganfall B5. Stroke magnetic resonance imaging is accurate in hyperacute intracerebral hemorrhage.


Instruction: What are magnetic resonance imaging and computed tomography in emergency assessment of patients?

Output: prospective comparison

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are magnetic resonance imaging and computed tomography in emergency assessment of patients?. ### Response: prospective comparison.


Instruction: What is the difference between resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke?

Output: Practical limitations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke?. ### Response: Practical limitations.


Instruction: When did the Lancet 369:293–298 appear?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Lancet 369:293–298 appear?. ### Response: 2007.


Instruction: What are the practical limitations of acute stroke MRI due to?

Output: patient-related problems

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the practical limitations of acute stroke MRI due to?. ### Response: patient-related problems.


Instruction: What is the name of the group that studies the deterioration of neurologic function in intracerebral hemorrhage?

Output: Recombinant Activated Factor VII Intracerebral Hemorrhage Trial Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that studies the deterioration of neurologic function in intracerebral hemorrhage?. ### Response: Recombinant Activated Factor VII Intracerebral Hemorrhage Trial Investigators.


Instruction: What are some of the predictors and associated factors of early neurologic deterioration?

Output: Hematoma growth

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the predictors and associated factors of early neurologic deterioration?. ### Response: Hematoma growth.


Instruction: How many patients were diagnosed with a stroke in 2004?

Output: 43

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were diagnosed with a stroke in 2004?. ### Response: 43.


Instruction: What is a determinant of mortality and poor outcome after intracerebral hemorrhage?

Output: Hematoma growth

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a determinant of mortality and poor outcome after intracerebral hemorrhage?. ### Response: Hematoma growth.


Instruction: What type of hemorrhage is involved in oral anticoagulant related intra-cerebral bleeding?

Output: Hematoma growth

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of hemorrhage is involved in oral anticoagulant related intra-cerebral bleeding?. ### Response: Hematoma growth.


Instruction: What is the name of the investigators that investigated hemomatoma growth?

Output: CHANT Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the investigators that investigated hemomatoma growth?. ### Response: CHANT Investigators.


Instruction: When was the last time a patient had a stroke?

Output: 1998

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last time a patient had a stroke?. ### Response: 1998.


Instruction: How many patients died from stroke in 2008?

Output: 47

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients died from stroke in 2008?. ### Response: 47.


Instruction: What is the name of the INTERACT1 Investigators?

Output: CHANT Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the INTERACT1 Investigators?. ### Response: CHANT Investigators.


Instruction: What are the outcomes in intracerebral hemorrhage?

Output: hematoma enlargement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the outcomes in intracerebral hemorrhage?. ### Response: hematoma enlargement.


Instruction: How many patients were enrolled in the interact1 study?

Output: 47

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were enrolled in the interact1 study?. ### Response: 47.


Instruction: What are factors to enlargement of spontaneous intracerebral hema-toma?

Output: Predisposing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are factors to enlargement of spontaneous intracerebral hema-toma?. ### Response: Predisposing.


Instruction: When did Stroke. 1997;28:2370-2375. doi: 10.1161/01.STR.28.12.2370.

Output: 1997

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Stroke. 1997;28:2370-2375. doi: 10.1161/01.STR.28.12.2370.. ### Response: 1997.


Instruction: What is a multivariate analysis of predictors of?

Output: hematoma enlargement in spontaneous intra-cerebral hemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a multivariate analysis of predictors of?. ### Response: hematoma enlargement in spontaneous intra-cerebral hemorrhage.


Instruction: What predicts hematoma expansion in intracerebral hemorrhage?

Output: Contrast extravasation on CT angiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What predicts hematoma expansion in intracerebral hemorrhage?. ### Response: Contrast extravasation on CT angiography.


Instruction: Contrast extravasation on CT angiography predicts what?

Output: hematoma expansion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Contrast extravasation on CT angiography predicts what?. ### Response: hematoma expansion.


Instruction: Neurology. 2007;68:889–894. doi: 10.212/01.wnl.0000257087.22852.21.

Output: 10.1212

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Neurology. 2007;68:889–894. doi: 10.212/01.wnl.0000257087.22852.21.. ### Response: 10.1212.


Instruction: What predicts hematoma expansion in acute intracerebral hemorrhage?

Output: CT angiography “spot sign

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What predicts hematoma expansion in acute intracerebral hemorrhage?. ### Response: CT angiography “spot sign.


Instruction: What does CT angiography predict?

Output: hematoma expansion in intracerebral hemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CT angiography predict?. ### Response: hematoma expansion in intracerebral hemorrhage.


Instruction: Stroke. 2007;38:1257–1262. doi: 10.1161/01.STR.0000259633.59404.f3.

Output: Stroke. 2007;38:1257–1262. doi: 10.1161/01.STR.0000259633.59404.f3.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Stroke. 2007;38:1257–1262. doi: 10.1161/01.STR.0000259633.59404.f3.. ### Response: Stroke. 2007;38:1257–1262. doi: 10.1161/01.STR.0000259633.59404.f3..


Instruction: What is currently in widespread use for ACC/AHA stage 2 HBP?

Output: Medication adherence to drug therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is currently in widespread use for ACC/AHA stage 2 HBP?. ### Response: Medication adherence to drug therapy.


Instruction: Adds new emphasis on correct measurement of BP by individuals at home or elsewhere?

Output: outside the clinic setting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Adds new emphasis on correct measurement of BP by individuals at home or elsewhere?. ### Response: outside the clinic setting.


Instruction: What is an important strategy for evaluating control of HBP?

Output: BP population

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an important strategy for evaluating control of HBP?. ### Response: BP population.


Instruction: What is a nonpharmacological intervention for ACC/AHA stage elevated BPPhysician group practice, accountable care organization, clinical integrated network, health plan, integrated delivery system?

Output: QM-2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a nonpharmacological intervention for ACC/AHA stage elevated BPPhysician group practice, accountable care organization, clinical integrated network, health plan, integrated delivery system?. ### Response: QM-2.


Instruction: In what year was high-quality evidence recommended for promoting lifestyle modification?

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was high-quality evidence recommended for promoting lifestyle modification?. ### Response: 2017.


Instruction: What is recommended in the 2017 Hypertension Clinical Practice Guidelines for ACC/AHA elevated BP population as an important strategy for controlling HBP?

Output: correct measurement of BP by individuals at home or elsewhere outside the clinic setting, as recommended in the 2017 Hypertension Clinical Practice Guidelines for this population as an important strategy for evaluating control of HBP .QM-1 Nonpharmacological interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended in the 2017 Hypertension Clinical Practice Guidelines for ACC/AHA elevated BP population as an important strategy for controlling HBP?. ### Response: correct measurement of BP by individuals at home or elsewhere outside the clinic setting, as recommended in the 2017 Hypertension Clinical Practice Guidelines for this population as an important strategy for evaluating control of HBP .QM-1 Nonpharmacological interventions.


Instruction: What is the recommendation for promoting lifestyle modification?

Output: strong

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommendation for promoting lifestyle modification?. ### Response: strong.


Instruction: What did the 2017 Hypertension Clinical Practice Guidelines recommend for ACC/AHA stage 1 population as an important strategy for controlling HBP?

Output: ASCVD risk ≥10%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the 2017 Hypertension Clinical Practice Guidelines recommend for ACC/AHA stage 1 population as an important strategy for controlling HBP?. ### Response: ASCVD risk ≥10%.


Instruction: What is the new emphasis on high-quality evidence and strong recommendation for promoting?

Output: lifestyle modification

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the new emphasis on high-quality evidence and strong recommendation for promoting?. ### Response: lifestyle modification.


Instruction: Nonpharmacological interventions for all ACC/AHA stages of HBP (composite measure combining PM-4, QM-1, and QM-2)Physician group practice, accountable care organization, clinical integrated network, health plan, integrated delivery system?

Output: QM-3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Nonpharmacological interventions for all ACC/AHA stages of HBP (composite measure combining PM-4, QM-1, and QM-2)Physician group practice, accountable care organization, clinical integrated network, health plan, integrated delivery system?. ### Response: QM-3.


Instruction: New emphasis on high-quality evidence and strong recommendation for promoting what?

Output: lifestyle modification

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: New emphasis on high-quality evidence and strong recommendation for promoting what?. ### Response: lifestyle modification.


Instruction: How many ACC/AHA stages of HBP population are recommended in the 2017 Hypertension Clinical Practice Guidelines?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many ACC/AHA stages of HBP population are recommended in the 2017 Hypertension Clinical Practice Guidelines?. ### Response: 3.


Instruction: What allows assessment of effectiveness for all stages combined?

Output: Composite measure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What allows assessment of effectiveness for all stages combined?. ### Response: Composite measure.


Instruction: What is the risk of ASCVD 10% for ACC/AHA stage 1?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of ASCVD 10% for ACC/AHA stage 1?. ### Response: ≥.


Instruction: What is a new emphasis on high-quality evidence and strong recommendation for assessing and promoting medication adherence?

Output: lifestyle modification

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a new emphasis on high-quality evidence and strong recommendation for assessing and promoting medication adherence?. ### Response: lifestyle modification.


Instruction: What was recommended in the 2017 Hypertension Clinical Practice Guidelines for the combined ACC/AHA stage 1 with ASCVD risk 10%?

Output: Medication adherence to drug therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was recommended in the 2017 Hypertension Clinical Practice Guidelines for the combined ACC/AHA stage 1 with ASCVD risk 10%?. ### Response: Medication adherence to drug therapy.


Instruction: What is an important strategy for controlling HBP?

Output: BP population

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an important strategy for controlling HBP?. ### Response: BP population.


Instruction: What are the guidelines for the per-formance of percutaneous transluminal coronary angioplasty?

Output: Williams DO, Gruntzig A, Kent KM, et al. Guidelines for the per-formance of percutaneous transluminal coronary angioplasty. Circu-lation. 1982;66:693–4.5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the guidelines for the per-formance of percutaneous transluminal coronary angioplasty?. ### Response: Williams DO, Gruntzig A, Kent KM, et al. Guidelines for the per-formance of percutaneous transluminal coronary angioplasty. Circu-lation. 1982;66:693–4.5.


Instruction: What is the name of the Task Force on Assessment of Diagnostic and Therapeutic Cardio-vascular Procedures?

Output: Subcommittee on Percutaneous TransluminalCoronary Angioplasty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Assessment of Diagnostic and Therapeutic Cardio-vascular Procedures?. ### Response: Subcommittee on Percutaneous TransluminalCoronary Angioplasty.


Instruction: What subcommittee is responsible for percutaneous transluminal coronary angioplasty?

Output: Subcommittee on Percutaneous TransluminalCoronary Angioplasty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What subcommittee is responsible for percutaneous transluminal coronary angioplasty?. ### Response: Subcommittee on Percutaneous TransluminalCoronary Angioplasty.


Instruction: What is the name of the committee that authored the guidelines?

Output: Subcommittee on Percutaneous TransluminalCoronary Angioplasty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the committee that authored the guidelines?. ### Response: Subcommittee on Percutaneous TransluminalCoronary Angioplasty.


Instruction: When was the Circulation 78:486-502.6 published?

Output: 1988

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circulation 78:486-502.6 published?. ### Response: 1988.


Instruction: How long was the mean treatment period?

Output: 7.8 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the mean treatment period?. ### Response: 7.8 years.


Instruction: What was the primary end point?

Output: time to death resulting from any cause

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary end point?. ### Response: time to death resulting from any cause.


Instruction: How much was the risk of cardiovascular events reduced?

Output: 60%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much was the risk of cardiovascular events reduced?. ### Response: 60%.


Instruction: How much was the risk of death from cardiovascular causes reduced with intensive versus conventional therapy?

Output: 60%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much was the risk of death from cardiovascular causes reduced with intensive versus conventional therapy?. ### Response: 60%.


Instruction: How many strokes were reduced from 30 to 6?

Output: 30

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes were reduced from 30 to 6?. ### Response: 30.


Instruction: What percentage of people who received intensive therapy had a lower risk of dying due to cardiovascular causes?

Output: 57%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of people who received intensive therapy had a lower risk of dying due to cardiovascular causes?. ### Response: 57%.


Instruction: How many strokes were fatal in the conventional group?

Output: Eighteen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes were fatal in the conventional group?. ### Response: Eighteen.


Instruction: How many of the strokes in the inten-sive group were fatal?

Output: 6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many of the strokes in the inten-sive group were fatal?. ### Response: 6.


Instruction: What do patients with AF and stable coronary arterydisease choose?

Output: oral anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do patients with AF and stable coronary arterydisease choose?. ### Response: oral anticoagulation.


Instruction: What is the target internationalnormalized ratio range?

Output: 2.0-3.0

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the target internationalnormalized ratio range?. ### Response: 2.0-3.0.


Instruction: What is a weakrecommendation, low quality evidence?

Output: rivaroxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a weakrecommendation, low quality evidence?. ### Response: rivaroxaban.


Instruction: In patients with AF in whom catheter ablation ofAF or implantation of cardiac electronic implantabledevices is planned, we suggest performing the procedure on uninterrupted VKA, dabigatran or rivaroxaban?

Output: 32

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with AF in whom catheter ablation ofAF or implantation of cardiac electronic implantabledevices is planned, we suggest performing the procedure on uninterrupted VKA, dabigatran or rivaroxaban?. ### Response: 32.


Instruction: What is rivaroxaban?

Output: Weakrecommendation, low quality evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is rivaroxaban?. ### Response: Weakrecommendation, low quality evidence.


Instruction: What should be based on the patient's CHA 2DS2-VAScthromboembolic risk pro file?

Output: long-term anticoagulations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be based on the patient's CHA 2DS2-VAScthromboembolic risk pro file?. ### Response: long-term anticoagulations.


Instruction: What should not be used as bridgingtherapy in the acute phase of ischemic stroke?

Output: Heparinoids

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not be used as bridgingtherapy in the acute phase of ischemic stroke?. ### Response: Heparinoids.


Instruction: How long should very early anticoagulation be used?

Output: 1 week

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long should very early anticoagulation be used?. ### Response: 1 week.


Instruction: What does the acute phase of ischemic stroke seem to increase the risk of?

Output: symptomaticintracranial hemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the acute phase of ischemic stroke seem to increase the risk of?. ### Response: symptomaticintracranial hemorrhage.


Instruction: What is the optimal timing of anticoagulation after acute ischmicstroke?

Output: unknown

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the optimal timing of anticoagulation after acute ischmicstroke?. ### Response: unknown.


Instruction: In patients with acute stroke withoutcontraindications, what is indicated as secondary prevention?

Output: long-term oralanticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with acute stroke withoutcontraindications, what is indicated as secondary prevention?. ### Response: long-term oralanticoagulation.


Instruction: What is indicated as secondary prevention?

Output: oralanticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is indicated as secondary prevention?. ### Response: oralanticoagulation.


Instruction: The optimal timing of anticoagulation earlyafter acute ischemic stroke is unknown.

Output: earlier than 1 week

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The optimal timing of anticoagulation earlyafter acute ischemic stroke is unknown.. ### Response: earlier than 1 week.


Instruction: Early use ofNOACs shows promise but requires testing in what?

Output: randomized controlled trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Early use ofNOACs shows promise but requires testing in what?. ### Response: randomized controlled trials.


Instruction: What should be bestarted within 2 weeks of acute ischemic stroke?

Output: oral anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be bestarted within 2 weeks of acute ischemic stroke?. ### Response: oral anticoagulation.


Instruction: What is used to guidetiming of anticoagulation?

Output: infarct size

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used to guidetiming of anticoagulation?. ### Response: infarct size.


Instruction: Infarct size is predictive of a higher risk of what?

Output: early recurrent ischemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Infarct size is predictive of a higher risk of what?. ### Response: early recurrent ischemia.


Instruction: What is the risk of early recurrent ischemia, hemorrhagic transformation of the infarct, and poor outcome?

Output: higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of early recurrent ischemia, hemorrhagic transformation of the infarct, and poor outcome?. ### Response: higher.


Instruction: Anticoagulation with NOACs soon after stroke has not been tested in randomized trials, but shows promise in observational studies?

Output: 37

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Anticoagulation with NOACs soon after stroke has not been tested in randomized trials, but shows promise in observational studies?. ### Response: 37.


Instruction: What type of studies show promise in observational studies?

Output: randomized controlled trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of studies show promise in observational studies?. ### Response: randomized controlled trials.


Instruction: In patients with high ischemic stroke risk, we suggest anticoagulation with an NOAC after acutespontaneous ICH (which includes subdural,subarachnoid, and intracerebral hemorrhages) after careful consideration of the risks and bene fits.

Output: 37

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with high ischemic stroke risk, we suggest anticoagulation with an NOAC after acutespontaneous ICH (which includes subdural,subarachnoid, and intracerebral hemorrhages) after careful consideration of the risks and bene fits.. ### Response: 37.


Instruction: What might be more favorable in those with deep ICH or without neuroimaging evidence of cerebral isch?

Output: The balance of net bene ﬁt from long-term oralanticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What might be more favorable in those with deep ICH or without neuroimaging evidence of cerebral isch?. ### Response: The balance of net bene ﬁt from long-term oralanticoagulation.


Instruction: What did some patien ts say they did not receive information on?

Output: the harms of having high blood pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did some patien ts say they did not receive information on?. ### Response: the harms of having high blood pressure.


Instruction: What did patients want communication around?

Output: the AEs  of medication

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did patients want communication around?. ### Response: the AEs  of medication.


Instruction: What would patients like to know about the AEs of medication?

Output: communication

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would patients like to know about the AEs of medication?. ### Response: communication.


Instruction: What is the 2015 ACC/AHA/HRS SVT Guideline e559 42?

Output: Page et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2015 ACC/AHA/HRS SVT Guideline e559 42?. ### Response: Page et al.


Instruction: What is Adenosine for paroxysmal supra-ventricular tachycardia: dose ranging and comparison with verapamil?

Output: Intravenous

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Adenosine for paroxysmal supra-ventricular tachycardia: dose ranging and comparison with verapamil?. ### Response: Intravenous.


Instruction: What is the name of the study that investigated the correlation of symp-toms with occurrence of paroxysmal supraventricular tachycardia or atrial fibrillation?

Output: The Flecainide Supraventricular Tachycardia Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the correlation of symp-toms with occurrence of paroxysmal supraventricular tachycardia or atrial fibrillation?. ### Response: The Flecainide Supraventricular Tachycardia Study Group.


Instruction: What is another name for the Flecainide Supraventricular Tachycardie Study Group?

Output: Flecainide Multicenter Investigators Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for the Flecainide Supraventricular Tachycardie Study Group?. ### Response: Flecainide Multicenter Investigators Group.


Instruction: What prevents recurrence of symptomatic paroxysmal supraventricular tachycardia?

Output: Flecainide acetate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What prevents recurrence of symptomatic paroxysmal supraventricular tachycardia?. ### Response: Flecainide acetate.


Instruction: What does Flecainide acetate prevent?

Output: recurrence of symptomatic paroxysmal supraventricular tachycardia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Flecainide acetate prevent?. ### Response: recurrence of symptomatic paroxysmal supraventricular tachycardia.


Instruction: What is the name of the study group that studied supraventricular tachycardia?

Output: The Flecainide Supraventricular Tachycardia Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study group that studied supraventricular tachycardia?. ### Response: The Flecainide Supraventricular Tachycardia Study Group.


Instruction: When was the Circulation of the Flecainide Study Group published?

Output: 1991

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circulation of the Flecainide Study Group published?. ### Response: 1991.


Instruction: What drug was used in a randomized study of paroxysmal supraventricular Tachy-cardias?

Output: Intravenous adenosine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug was used in a randomized study of paroxysmal supraventricular Tachy-cardias?. ### Response: Intravenous adenosine.


Instruction: Which drug did the investigators use in their study?

Output: Intravenous adenosine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which drug did the investigators use in their study?. ### Response: Intravenous adenosine.


Instruction: What is the name of the syndrome in a general population younger than 50 years of age in an era of radiofrequency catheter ablation?

Output: Wolff-Parkinson-White syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the syndrome in a general population younger than 50 years of age in an era of radiofrequency catheter ablation?. ### Response: Wolff-Parkinson-White syndrome.