Instruction: What was a 1.2% stroke complication rate for catheter angiography?

Output: The 30-day stroke morbidity and all-cause mortality for CEA was 2.3%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a 1.2% stroke complication rate for catheter angiography?. ### Response: The 30-day stroke morbidity and all-cause mortality for CEA was 2.3%,.


Instruction: Why would complications of angiogram not be included in the risk of surgery?

Output: an angiogram would not have been performed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why would complications of angiogram not be included in the risk of surgery?. ### Response: an angiogram would not have been performed.


Instruction: What would not have been performed if surgery were not contemplated?

Output: an angiogram

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would not have been performed if surgery were not contemplated?. ### Response: an angiogram.


Instruction: What is SPRINT?

Output: Systolic Blood Pressure Intervention Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SPRINT?. ### Response: Systolic Blood Pressure Intervention Trial.


Instruction: What was the systolic BP goal?

Output: 120 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the systolic BP goal?. ### Response: 120 mm Hg.


Instruction: Who was the more aggressive target?

Output: persons with a systolic BP goal of 120 mm Hg and those with a goal of 140 mm Hg.6 The results favored the more aggressive target, with lower rates of a composite of cardiovascular events and all-cause  mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the more aggressive target?. ### Response: persons with a systolic BP goal of 120 mm Hg and those with a goal of 140 mm Hg.6 The results favored the more aggressive target, with lower rates of a composite of cardiovascular events and all-cause  mortality.


Instruction: What is a composite of cardiovascular events and all-cause mortality?

Output: lower rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a composite of cardiovascular events and all-cause mortality?. ### Response: lower rates.


Instruction: The current guideline panel reviewed existing trial evidence to reach the conclusions summarized in what?

Output: Table 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The current guideline panel reviewed existing trial evidence to reach the conclusions summarized in what?. ### Response: Table 1.


Instruction: What does the AAFP/ACP guideline make a strong recommendation to treat adults 60 years and older to?

Output: a systolic BP of less than 150 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the AAFP/ACP guideline make a strong recommendation to treat adults 60 years and older to?. ### Response: a systolic BP of less than 150 mm Hg.


Instruction: What is the recommended systolic BP for adults 60 years and older?

Output: less than 150 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommended systolic BP for adults 60 years and older?. ### Response: less than 150 mm Hg.


Instruction: What is a weak recommendation made to treat those at high cardiovas -cular risk?

Output: low-quality evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a weak recommendation made to treat those at high cardiovas -cular risk?. ### Response: low-quality evidence.


Instruction: The panel found the body of what?

Output: evidence supporting a lower BP target to be of low quality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The panel found the body of what?. ### Response: evidence supporting a lower BP target to be of low quality.


Instruction: What did the panel find the body of evidence supporting a lower BP target to be of?

Output: low quality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the panel find the body of evidence supporting a lower BP target to be of?. ### Response: low quality.


Instruction: The background evidence review noted inconsistent trial results with what?

Output: imprecise Table 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The background evidence review noted inconsistent trial results with what?. ### Response: imprecise Table 1.


Instruction: What does the College of Physicians recommend for pharmacologic treatment of hypertension in adults 60 years and older?

Output: systolic BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the College of Physicians recommend for pharmacologic treatment of hypertension in adults 60 years and older?. ### Response: systolic BP.


Instruction: What is the target systolic BP of less than 150 mm Hg?

Output: reduce the risk of mortality, stroke, and cardiac events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the target systolic BP of less than 150 mm Hg?. ### Response: reduce the risk of mortality, stroke, and cardiac events.


Instruction: What is a target systolic BP of less than 150 mm Hg to reduce the risk of mortality, stroke, and cardiac events?

Output: adults 60 years and older

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a target systolic BP of less than 150 mm Hg to reduce the risk of mortality, stroke, and cardiac events?. ### Response: adults 60 years and older.


Instruction: How old are adults 60 years and older with a history of stroke or transient ischemic attack?

Output: less than 150 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old are adults 60 years and older with a history of stroke or transient ischemic attack?. ### Response: less than 150 mm Hg.


Instruction: Attaining a target systolic BP of less than 140 mm Hg to reduce the risk of recurrent stroke is what?

Output: initiating or intensifying pharmacologic treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Attaining a target systolic BP of less than 140 mm Hg to reduce the risk of recurrent stroke is what?. ### Response: initiating or intensifying pharmacologic treatment.


Instruction: In adults 60 years and older at high cardiovascular risk, consider initiating or intensifying pharmacologic treatment to achieve what goal?

Output: reduce the risk of recurrent stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In adults 60 years and older at high cardiovascular risk, consider initiating or intensifying pharmacologic treatment to achieve what goal?. ### Response: reduce the risk of recurrent stroke.


Instruction: What is the target systolic BP of less than 140 mm Hg?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the target systolic BP of less than 140 mm Hg?. ### Response: stroke.


Instruction: What is BP = blood pressure?

Output: 120 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is BP = blood pressure?. ### Response: 120 mm Hg.


Instruction: How was shared decision making emphasized?

Output: For each recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was shared decision making emphasized?. ### Response: For each recommendation.


Instruction: Where is the American Family Physician website located?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the American Family Physician website located?. ### Response: www.aafp.org/afp.


Instruction: What year was the American Academy of Family Physicians founded?

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the American Academy of Family Physicians founded?. ### Response: 2017.


Instruction: Who can use the website for private use?

Output: one individual user

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who can use the website for private use?. ### Response: one individual user.


Instruction: What is NICE 2018's guideline for Chronic Heart Failure?

Output: approach to care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE 2018's guideline for Chronic Heart Failure?. ### Response: approach to care.


Instruction: What is the ISBN number for follow up studies?

Output: 978 -1-4731 -3093 -7 330

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ISBN number for follow up studies?. ### Response: 978 -1-4731 -3093 -7 330.


Instruction: What is the risk difference with MDTn (95% CI)?

Output: Relative effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk difference with MDTn (95% CI)?. ### Response: Relative effect.


Instruction: Hospitalisations 158 (1 study) 6 months  LOWa, b due to risk of bias, imprecision rate ratio 0.92 (0.68 to 1.22) 1203 per 1000 96 fewer per 10 00?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hospitalisations 158 (1 study) 6 months  LOWa, b due to risk of bias, imprecision rate ratio 0.92 (0.68 to 1.22) 1203 per 1000 96 fewer per 10 00?. ### Response: ⊝⊝.


Instruction: How many fewer deaths per 10 00?

Output: 96

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many fewer deaths per 10 00?. ### Response: 96.


Instruction: How many more deaths per 1 000?

Output: 52

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many more deaths per 1 000?. ### Response: 52.


Instruction: Why is the risk of bias VERY low?

Output: imprecision

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is the risk of bias VERY low?. ### Response: imprecision.


Instruction: What is the RR of imprecision?

Output: 1.24

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the RR of imprecision?. ### Response: 1.24.


Instruction: What is a proxy for QoL?

Output: NYHA class change

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a proxy for QoL?. ### Response: NYHA class change.


Instruction: What is the scale from: 1 to 4?

Output: 148 fewer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the scale from: 1 to 4?. ### Response: 148 fewer.


Instruction: What was the mean NYHA class change in the control groups?

Output: -0.3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean NYHA class change in the control groups?. ### Response: -0.3.


Instruction: What is a proxy for qol?

Output: NYHA class change

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a proxy for qol?. ### Response: NYHA class change.


Instruction: How much higher was the ACE -I 145 in the intervention groups?

Output: 0.10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much higher was the ACE -I 145 in the intervention groups?. ### Response: 0.10.


Instruction: What was the imprecision RR?

Output: 1.24

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the imprecision RR?. ### Response: 1.24.


Instruction: Why was there a risk of bias in the study?

Output: indirectness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was there a risk of bias in the study?. ### Response: indirectness.


Instruction: What percentage of the evidence was at high risk of bias?

Output: majority

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the evidence was at high risk of bias?. ### Response: majority.


Instruction: How many increments were downgraded if the majority of evidence was high risk?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many increments were downgraded if the majority of evidence was high risk?. ### Response: 2.


Instruction: By how many increments if the majority of the evidence was at very high risk of bias?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: By how many increments if the majority of the evidence was at very high risk of bias?. ### Response: 2.


Instruction: Downgraded due to indirectness as a proxy measure?

Output: quality of life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Downgraded due to indirectness as a proxy measure?. ### Response: quality of life.


Instruction: What was downgraded due to indirectness as a proxy measure of quality of life?

Output: High risk, Mid -length, Case -management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was downgraded due to indirectness as a proxy measure of quality of life?. ### Response: High risk, Mid -length, Case -management.


Instruction: What was reported by the study?

Output: Downgraded due to indirectness as a proxy measure of quality of life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was reported by the study?. ### Response: Downgraded due to indirectness as a proxy measure of quality of life.


Instruction: High risk, Mid-length, Case management Table 111: Clinical Evidence Summary: J-HOMECARE

Output: bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: High risk, Mid-length, Case management Table 111: Clinical Evidence Summary: J-HOMECARE. ### Response: bias.


Instruction: What is the difference between Mid-length Case management and Cardiology clinic?

Output: high risk HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between Mid-length Case management and Cardiology clinic?. ### Response: high risk HF.


Instruction: What does GRADE stand for?

Output: Quality of the evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does GRADE stand for?. ### Response: Quality of the evidence.


Instruction: What is the risk difference with MDTcm (95% CI) Hospitalisations 98 (1 study)  VERY LOWa,b,c HR 0.5 2 (0.28 to estimated risk: 213 per 1000d 96 fewer per 10 00?

Output: ⊕⊝⊝⊝  VERY LOWa,b,c HR 0.5 2  (0.28 to estimated risk:  213 per 1000d 96 fewer per 10 00 (from 4 fewer to 148 fewer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk difference with MDTcm (95% CI) Hospitalisations 98 (1 study)  VERY LOWa,b,c HR 0.5 2 (0.28 to estimated risk: 213 per 1000d 96 fewer per 10 00?. ### Response: ⊕⊝⊝⊝  VERY LOWa,b,c HR 0.5 2  (0.28 to estimated risk:  213 per 1000d 96 fewer per 10 00 (from 4 fewer to 148 fewer.


Instruction: What is the name of the FAST-MAG Trial?

Output: Field Administration of Stroke Therapy–Magnesium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the FAST-MAG Trial?. ### Response: Field Administration of Stroke Therapy–Magnesium.


Instruction: What is a tool for paramedics?

Output: Severity-based stroke triage algorithm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a tool for paramedics?. ### Response: Severity-based stroke triage algorithm.


Instruction: How is the LA Motor Scale validated?

Output: Field

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the LA Motor Scale validated?. ### Response: Field.


Instruction: What is a tool for paramedic assessment of stroke severity?

Output: Los Angeles Motor Scale

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a tool for paramedic assessment of stroke severity?. ### Response: Los Angeles Motor Scale.


Instruction: What does the Los Angeles Motor Scale do?

Output: a tool for paramedic assessment of stroke severity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Los Angeles Motor Scale do?. ### Response: a tool for paramedic assessment of stroke severity.


Instruction: When did the American Heart Association publish a Severity-based assessment?

Output: December 1, 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the American Heart Association publish a Severity-based assessment?. ### Response: December 1, 2017.


Instruction: What is the name of the tool used in Prehosp Emerg Care?

Output: Cincinnati Stroke Triage Assessment Tool

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the tool used in Prehosp Emerg Care?. ### Response: Cincinnati Stroke Triage Assessment Tool.


Instruction: What does the American Heart Association call the Severity-based stroke triage algorithm for EMS?

Output: missionlifelinestroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the American Heart Association call the Severity-based stroke triage algorithm for EMS?. ### Response: missionlifelinestroke.


Instruction: When is time to treatment with intravenous tissue plasminogen activator?

Output: acute ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is time to treatment with intravenous tissue plasminogen activator?. ### Response: acute ischemic stroke.


Instruction: What is the effect of intravenous tissue plasminogen activator on outcome from acute ischemic stroke?

Output: Time to treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of intravenous tissue plasminogen activator on outcome from acute ischemic stroke?. ### Response: Time to treatment.


Instruction: What is Schwamm LH's title?

Output: Fonarow GC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Schwamm LH's title?. ### Response: Fonarow GC.


Instruction: When was Schwamm's last name published?

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Schwamm's last name published?. ### Response: 2016.


Instruction: How is time to treat with endovascular therapy?

Output: intravenous tissue plasminogen activator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is time to treat with endovascular therapy?. ### Response: intravenous tissue plasminogen activator.


Instruction: What is a meta-analysis of time to treatment with endovascular throm-bectomy and outcomes from ischemic stroke?

Output: stepped-wedge randomized trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a meta-analysis of time to treatment with endovascular throm-bectomy and outcomes from ischemic stroke?. ### Response: stepped-wedge randomized trial.


Instruction: What is the doi: 10.1001/jama.2016.13647 43?

Output: 316:1279–1288

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the doi: 10.1001/jama.2016.13647 43?. ### Response: 316:1279–1288.


Instruction: What is a retrospective analysis of systems of stroke care and reduction in 30-day mortality?

Output: Neurology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a retrospective analysis of systems of stroke care and reduction in 30-day mortality?. ### Response: Neurology.


Instruction: Neurology. 2016;86:898-904. doi: 10.1212/WNL.0000000000002443 44.

Output: Neurology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Neurology. 2016;86:898-904. doi: 10.1212/WNL.0000000000002443 44.. ### Response: Neurology.


Instruction: What is the name of the organization that certifies stroke centers?

Output: A VC II Trial Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that certifies stroke centers?. ### Response: A VC II Trial Group.


Instruction: What year did Stroke.48:412–419.

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Stroke.48:412–419.. ### Response: 2017.


Instruction: What is a multi-level intervention to increase community hospital use of alteplase?

Output: a cluster-randomised controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a multi-level intervention to increase community hospital use of alteplase?. ### Response: a cluster-randomised controlled trial.


Instruction: What is the name of the cluster-randomised controlled trial to increase community hospital use of alteplase for acute stroke?

Output: INSTINCT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the cluster-randomised controlled trial to increase community hospital use of alteplase for acute stroke?. ### Response: INSTINCT.


Instruction: When did Lancet Neurol. 2013;12:139-148?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Lancet Neurol. 2013;12:139-148?. ### Response: 2013.


Instruction: What is INSTINCT?

Output: Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is INSTINCT?. ### Response: Investigators.


Instruction: Who are the PRomoting ACute Thrombolysis in Ischemic StrokE Investigators?

Output: Dirks M, Niessen LW, van Wijngaarden JD, Koudstaal PJ,  Franke CL, van Oostenbrugge RJ, Huijsman R, Lingsma HF, Minkman MM, Dippel DW

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who are the PRomoting ACute Thrombolysis in Ischemic StrokE Investigators?. ### Response: Dirks M, Niessen LW, van Wijngaarden JD, Koudstaal PJ,  Franke CL, van Oostenbrugge RJ, Huijsman R, Lingsma HF, Minkman MM, Dippel DW.


Instruction: What does PRactISE promote in acute ischemic stroke?

Output: throm-bolysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does PRactISE promote in acute ischemic stroke?. ### Response: throm-bolysis.


Instruction: When did Stroke. 201142:1325-1330?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Stroke. 201142:1325-1330?. ### Response: 2011.


Instruction: What group is Bravant E, Rabilloud M, Schott AM on behalf of?

Output: A VC II Trial Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What group is Bravant E, Rabilloud M, Schott AM on behalf of?. ### Response: A VC II Trial Group.


Instruction: Improving access to throm-bolysis and inhospital management times in ischemic stroke: a stepped-wedge randomized trial?

Output: A VC II Trial Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Improving access to throm-bolysis and inhospital management times in ischemic stroke: a stepped-wedge randomized trial?. ### Response: A VC II Trial Group.


Instruction: Stroke. 2018;49:405–411. doi: 10.1161/STROKEAHA.117.018335.

Output: bolysis in acute ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Stroke. 2018;49:405–411. doi: 10.1161/STROKEAHA.117.018335.. ### Response: bolysis in acute ischemic stroke.


Instruction: What may be perceived to be greater for a young patient with AAOCA than for many other con-ditions?

Output: ACHD Guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be perceived to be greater for a young patient with AAOCA than for many other con-ditions?. ### Response: ACHD Guideline.


Instruction: What is often a clinical urge to seek a reason to do?

Output: surgical repair

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is often a clinical urge to seek a reason to do?. ### Response: surgical repair.


Instruction: What is the clinical urge to seek a reason for doing something like surgical repair?

Output: because the available data do not identify clinical fea-tures that provide reassurance that a patient is at low risk of cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the clinical urge to seek a reason for doing something like surgical repair?. ### Response: because the available data do not identify clinical fea-tures that provide reassurance that a patient is at low risk of cardiovascular events.


Instruction: What does the available data do not identify that provide reassurance that a patient is at low risk of?

Output: clinical fea-tures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the available data do not identify that provide reassurance that a patient is at low risk of?. ### Response: clinical fea-tures.


Instruction: Evidence demonstrating that surgical repair ameliorates SCD risk is derived from large enough cohorts followed over how many years?

Output: a sufficient period of time

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Evidence demonstrating that surgical repair ameliorates SCD risk is derived from large enough cohorts followed over how many years?. ### Response: a sufficient period of time.


Instruction: What is not available to ameliorate SCD risk?

Output: surgical repair

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not available to ameliorate SCD risk?. ### Response: surgical repair.


Instruction: What are the recommendations for Anomalous Coronary Artery Evaluation summarized in?

Output: Online Data Supplement 51

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the recommendations for Anomalous Coronary Artery Evaluation summarized in?. ### Response: Online Data Supplement 51.


Instruction: What is recommended for evaluation of anomalous coronary artery?

Output: Coronary angiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for evaluation of anomalous coronary artery?. ### Response: Coronary angiography.


Instruction: What should be performed in patients with anomalous aortic origin of the left coronary from the right sinus?

Output: surgical repair

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be performed in patients with anomalous aortic origin of the left coronary from the right sinus?. ### Response: surgical repair.


Instruction: What can all delineate the proximal course of the coronary artery?

Output: CTA, CMR, and catheterization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can all delineate the proximal course of the coronary artery?. ### Response: CTA, CMR, and catheterization.


Instruction: What is generally preferred because it has superior spatial and tem-poral resolution?

Output: CTA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is generally preferred because it has superior spatial and tem-poral resolution?. ### Response: CTA.


Instruction: CMR may also pro-vide adequate delineation of what?

Output: the relationship of the coronary artery to the aorta, PA and other structures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: CMR may also pro-vide adequate delineation of what?. ### Response: the relationship of the coronary artery to the aorta, PA and other structures.


Instruction: What can be helpful when there is concern about stenosis in the coronary artery?

Output: Coronary angiography by catheterization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be helpful when there is concern about stenosis in the coronary artery?. ### Response: Coronary angiography by catheterization.


Instruction: What may also pro-vide adequate delineation of the relationship of the coronare artery to the aorta, PA and other structures?

Output: CMR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may also pro-vide adequate delineation of the relationship of the coronare artery to the aorta, PA and other structures?. ### Response: CMR.


Instruction: Is there concern about stenosis in the coronary artery or when concomitant hemodynamic evaluation for shunt assessment or intravascular ultrasonog-raphy/flow evaluation is needed?

Output: when there is concern about stenosis in the coronary artery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Is there concern about stenosis in the coronary artery or when concomitant hemodynamic evaluation for shunt assessment or intravascular ultrasonog-raphy/flow evaluation is needed?. ### Response: when there is concern about stenosis in the coronary artery.


Instruction: Assessment of AAOCA is enhanced when the precise anatomy and physiological impact of what are understood?

Output: coronary artery anomaly

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Assessment of AAOCA is enhanced when the precise anatomy and physiological impact of what are understood?. ### Response: coronary artery anomaly.


Instruction: What may all influence the clinical course and management options?

Output: CTA, CMR, and catheterization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may all influence the clinical course and management options?. ### Response: CTA, CMR, and catheterization.


Instruction: What will better inform clinical decisions?

Output: Understanding these issues

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will better inform clinical decisions?. ### Response: Understanding these issues.


Instruction: What is a surgical intervention to involve unroofing or coronary revascularization for patients with concomitant fixed obstruction?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a surgical intervention to involve unroofing or coronary revascularization for patients with concomitant fixed obstruction?. ### Response: *.


Instruction: What are patients with familial hypercholesterolemia at risk of having an early ASCVD event?

Output: signifi-cant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients with familial hypercholesterolemia at risk of having an early ASCVD event?. ### Response: signifi-cant.


Instruction: What is the use of risk calculators?

Output: not applicable to these patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the use of risk calculators?. ### Response: not applicable to these patients.


Instruction: What is not applicable to early ASCVD patients?

Output: risk calculators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not applicable to early ASCVD patients?. ### Response: risk calculators.


Instruction: Other studies have found overestimation of what with the PCE?

Output: risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Other studies have found overestimation of what with the PCE?. ### Response: risk.


Instruction: What could lead to overtreatment of individuals less likely to receive net benefit from preventive pharmacotherapies over the next decade?

Output: overestimation of risk with the PCE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could lead to overtreatment of individuals less likely to receive net benefit from preventive pharmacotherapies over the next decade?. ### Response: overestimation of risk with the PCE.


Instruction: What may be suboptimally calibrated in more modern populations as compared with older cohorts?

Output: The PCE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be suboptimally calibrated in more modern populations as compared with older cohorts?. ### Response: The PCE.


Instruction: What is the risk of ASCVD among adults at bor -derline and intermediate risk?

Output: ≥7.5% to <20%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of ASCVD among adults at bor -derline and intermediate risk?. ### Response: ≥7.5% to <20%).


Instruction: What are some factors that can be used to revise the 10-year risk estimate?

Output: risk-enhancing clinical factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some factors that can be used to revise the 10-year risk estimate?. ### Response: risk-enhancing clinical factors.


Instruction: What type of ancestry may be a factor in having a family history of preeclampsia?

Output: South Asian

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of ancestry may be a factor in having a family history of preeclampsia?. ### Response: South Asian.


Instruction: What is CKD?

Output: chronic kidney disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CKD?. ### Response: chronic kidney disease.


Instruction: Which type of biomarkers may be elevated per-sistently?

Output: inflammatory markers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which type of biomarkers may be elevated per-sistently?. ### Response: inflammatory markers.


Instruction: What type of biomarkers are elevated per -sistently?

Output: inflammatory markers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of biomarkers are elevated per -sistently?. ### Response: inflammatory markers.


Instruction: What is the risk estimate for individu-als in the borderline- or intermediate-risk categories?

Output: ≥7.5% to <20%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk estimate for individu-als in the borderline- or intermediate-risk categories?. ### Response: ≥7.5% to <20%).


Instruction: What type of testing is reasonable to more accurately reclassify the risk estimate upward or downward?

Output: subclinical coronary atherosclerosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of testing is reasonable to more accurately reclassify the risk estimate upward or downward?. ### Response: subclinical coronary atherosclerosis.


Instruction: What can be a useful measure for individuals with intermediate predicted risk by the PCE?

Output: coronary artery calcium measurement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be a useful measure for individuals with intermediate predicted risk by the PCE?. ### Response: coronary artery calcium measurement.


Instruction: What can be a useful tool in refining risk assessment for preventive interventions like statin therapy?

Output: coronary artery calcium measurement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be a useful tool in refining risk assessment for preventive interventions like statin therapy?. ### Response: coronary artery calcium measurement.


Instruction: What can coronary artery calcium measurement reclassify risk upward?

Output: coronary artery calcium score is ≥100 Agatston units (AU) or ≥75th age/sex/race percentile

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can coronary artery calcium measurement reclassify risk upward?. ### Response: coronary artery calcium score is ≥100 Agatston units (AU) or ≥75th age/sex/race percentile.


Instruction: What units are used to classify borderline- or intermediate-risk patients with elevated coronary artery calcium?

Output: risk calculators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What units are used to classify borderline- or intermediate-risk patients with elevated coronary artery calcium?. ### Response: risk calculators.


Instruction: What are AU units used for?

Output: coronary artery calcium score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are AU units used for?. ### Response: coronary artery calcium score.


Instruction: What will have event rates that clearly exceed benefit thresholds?

Output: borderline- or intermediate-risk patients with elevated coronary artery calcium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will have event rates that clearly exceed benefit thresholds?. ### Response: borderline- or intermediate-risk patients with elevated coronary artery calcium.


Instruction: Those with coronary artery calcium scores of zero will have what?

Output: event rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Those with coronary artery calcium scores of zero will have what?. ### Response: event rates.


Instruction: What is the name of the Danish trial in Acute Myocardial Infarction?

Output: DANAMI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Danish trial in Acute Myocardial Infarction?. ### Response: DANAMI.


Instruction: What is invasive versus conservative treatment in patients withinducible ischemia after thrombolysis?

Output: Percutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is invasive versus conservative treatment in patients withinducible ischemia after thrombolysis?. ### Response: Percutaneous coronary intervention.


Instruction: What is the difference between Culprit vessel percuta-neous coronary intervention and multivessel and staged percutaneouscoronary intervention for ST-segment elevation myocardial infarctionpatients?

Output: multivessel disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between Culprit vessel percuta-neous coronary intervention and multivessel and staged percutaneouscoronary intervention for ST-segment elevation myocardial infarctionpatients?. ### Response: multivessel disease.


Instruction: When was the J Am Coll Cardiol Intv published?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol Intv published?. ### Response: 2010.


Instruction: How long did it take for 14-day survivors of acute myocarcinoma to survive after revascularisation?

Output: 1-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for 14-day survivors of acute myocarcinoma to survive after revascularisation?. ### Response: 1-year.


Instruction: What is the name of the prospective cohort study?

Output: Early revascularisation and 1-year survivalin 14-day survivors of acute myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective cohort study?. ### Response: Early revascularisation and 1-year survivalin 14-day survivors of acute myocardial infarction.


Instruction: When was the Lancet 359:1805-11.414.

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Lancet 359:1805-11.414.. ### Response: 2002.


Instruction: What is one of the outcomes after acute myocardial infarction at hospitals with and without on-site revascularization facilities in Canada?

Output: Waiting times, revascularizationmodality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the outcomes after acute myocardial infarction at hospitals with and without on-site revascularization facilities in Canada?. ### Response: Waiting times, revascularizationmodality.


Instruction: What is the name of the study that compared percu-taneous transluminal coronary angioplasty and medical therapy in stablesurvivors of acute myocardial infarction with single vessel disease?

Output: Arbeitsgemeinschaft Leitende Kardiologische Kranken-hausarzte

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that compared percu-taneous transluminal coronary angioplasty and medical therapy in stablesurvivors of acute myocardial infarction with single vessel disease?. ### Response: Arbeitsgemeinschaft Leitende Kardiologische Kranken-hausarzte.


Instruction: What did the Arbeitsgemeinschaft Leitende Kardiologische Kranken-hausarzte do?

Output: Randomized comparison of percu-taneous transluminal coronary angioplasty and medical therapy in stablesurvivors of acute myocardial infarction with single vessel disease: astudy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Arbeitsgemeinschaft Leitende Kardiologische Kranken-hausarzte do?. ### Response: Randomized comparison of percu-taneous transluminal coronary angioplasty and medical therapy in stablesurvivors of acute myocardial infarction with single vessel disease: astudy.


Instruction: When was the Circulation.108:1324–8.416 published?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circulation.108:1324–8.416 published?. ### Response: 2003.


Instruction: What is the name of the multilevel analysis of patients in ASSENT-2?

Output: International differences inin-hospital revascularization and outcomes following acute myocardialinfarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multilevel analysis of patients in ASSENT-2?. ### Response: International differences inin-hospital revascularization and outcomes following acute myocardialinfarction.


Instruction: What is Gibson CM, Karha J, Murphy SA, et al. associated with?

Output: Early and long-term clinicaloutcomes associated with reinfarction following fibrinolytic adminis-tration in the Thrombolysis in Myocardial Infarction trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Gibson CM, Karha J, Murphy SA, et al. associated with?. ### Response: Early and long-term clinicaloutcomes associated with reinfarction following fibrinolytic adminis-tration in the Thrombolysis in Myocardial Infarction trials.


Instruction: What is the name of the randomized multi-centre trial of DEsobstructionCOronaire en Post-Infarctus?

Output: DECOPI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized multi-centre trial of DEsobstructionCOronaire en Post-Infarctus?. ### Response: DECOPI.


Instruction: What is DECOPI?

Output: a randomized multi-centre trial ofoccluded artery angioplasty after acute myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is DECOPI?. ### Response: a randomized multi-centre trial ofoccluded artery angioplasty after acute myocardial infarction.


Instruction: What is the name of the randomized multi-centre trial of angioplasty after acute myocardial infarction?

Output: DECOPI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized multi-centre trial of angioplasty after acute myocardial infarction?. ### Response: DECOPI.


Instruction: When was the EurHeart J.25:2187–94.420?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the EurHeart J.25:2187–94.420?. ### Response: 2004.


Instruction: What is a one-year survival following revascularization for patients with a heart attack?

Output: 14-day survivors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a one-year survival following revascularization for patients with a heart attack?. ### Response: 14-day survivors.


Instruction: What is one-year survival following early revascularization for cardiogenic shock?

Output: One-year survival followingearly revascularization for cardiogenic shock. JAMA. 2001;285:190–2.422

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one-year survival following early revascularization for cardiogenic shock?. ### Response: One-year survival followingearly revascularization for cardiogenic shock. JAMA. 2001;285:190–2.422.


Instruction: What is the name of the randomized evaluation of earlyrevascularisation to treat shock?

Output: The (Swiss) Multicenter Trial of Angioplasty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized evaluation of earlyrevascularisation to treat shock?. ### Response: The (Swiss) Multicenter Trial of Angioplasty.


Instruction: What does earlyrevascularization treat?

Output: shock complicating acute myocardialinfarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does earlyrevascularization treat?. ### Response: shock complicating acute myocardialinfarction.


Instruction: What is the name of the (Swiss) Multicenter Trial of Angioplasty for Shock(S)MASH?

Output: The (Swiss) Multicenter Trial of Angioplasty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the (Swiss) Multicenter Trial of Angioplasty for Shock(S)MASH?. ### Response: The (Swiss) Multicenter Trial of Angioplasty.


Instruction: When was the Eur Heart J 20:1030–8.424.

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Eur Heart J 20:1030–8.424.. ### Response: 1999.


Instruction: What is e540S Antithrombotic Therapy for Atrial Fibrillation?

Output: Quality Assessment Summary of Findings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is e540S Antithrombotic Therapy for Atrial Fibrillation?. ### Response: Quality Assessment Summary of Findings.


Instruction: What is the Risk of Bias Inconsistency Indirectness Imprecision?

Output: Publication Bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Risk of Bias Inconsistency Indirectness Imprecision?. ### Response: Publication Bias.


Instruction: What is the 95% CI of VKA?

Output: No Therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 95% CI of VKA?. ### Response: No Therapy.


Instruction: What is important outcome of treatment?

Output: Burden

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is important outcome of treatment?. ### Response: Burden.


Instruction: No therapyWarfarin: daily medication, lifestyle limitations, dietary restrictions, frequent blood testing and clinic visitsWhat is ATRIA 5?

Output: Anticoagulation and Risk Factors in Atrial Fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No therapyWarfarin: daily medication, lifestyle limitations, dietary restrictions, frequent blood testing and clinic visitsWhat is ATRIA 5?. ### Response: Anticoagulation and Risk Factors in Atrial Fibrillation.


Instruction: How many Atrial Fibrillation Aspirin and Anticoagulation are there?

Output: 5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many Atrial Fibrillation Aspirin and Anticoagulation are there?. ### Response: 5.


Instruction: What is the name of the ATRIA 5 anticoagulation and risk factors?

Output: AFASAK

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the ATRIA 5 anticoagulation and risk factors?. ### Response: AFASAK.


Instruction: How many atrial fibrillation aspirins are there in the U.S.?

Output: 5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many atrial fibrillation aspirins are there in the U.S.?. ### Response: 5.


Instruction: What is the name of the European Atrial Fibrillation Trial?

Output: EAFT  5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the European Atrial Fibrillation Trial?. ### Response: EAFT  5.


Instruction: What is not applicable to IPD 5?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not applicable to IPD 5?. ### Response: N/A.


Instruction: How many risk ratios are there in RR5?

Output: 5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many risk ratios are there in RR5?. ### Response: 5.


Instruction: What is the abbreviation for Nonrheumatic Atrial Fibrillation?

Output: SPINAF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the abbreviation for Nonrheumatic Atrial Fibrillation?. ### Response: SPINAF.


Instruction: How many RCTs of adjusted-dose VKA therapy were included in the meta-analysis?

Output: 6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs of adjusted-dose VKA therapy were included in the meta-analysis?. ### Response: 6.


Instruction: How many RCTs of adjusted-dose VKA therapy compared to no antithrombotic therapy?

Output: 6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs of adjusted-dose VKA therapy compared to no antithrombotic therapy?. ### Response: 6.


Instruction: What was the mortality rate in untreated (no warfarin) patients?

Output: 5.33 per 100 person-y

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mortality rate in untreated (no warfarin) patients?. ### Response: 5.33 per 100 person-y.


Instruction: What percentage of patients in ATRIA had a CHADS 2 score of /H11350?

Output: 78%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients in ATRIA had a CHADS 2 score of /H11350?. ### Response: 78%).


Instruction: What does c VKA therapy likely not lead to?

Output: any reductions in all-cause mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does c VKA therapy likely not lead to?. ### Response: any reductions in all-cause mortality.


Instruction: In low-risk patients with a CHADS 2 score of 0 what does therapy likely not lead to?

Output: reductions in all-cause mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In low-risk patients with a CHADS 2 score of 0 what does therapy likely not lead to?. ### Response: reductions in all-cause mortality.


Instruction: What does evidence suggest about absolute reductions in ischemic stroke heavily depend on?

Output: stroke risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does evidence suggest about absolute reductions in ischemic stroke heavily depend on?. ### Response: stroke risk.


Instruction: What is stroke risk?

Output: small reductions at low CHADS 2  score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is stroke risk?. ### Response: small reductions at low CHADS 2  score.


Instruction: What is the absolute increase in intracranial hemorrhage consistent across CHADS 2 categories?

Output: relatively consistent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the absolute increase in intracranial hemorrhage consistent across CHADS 2 categories?. ### Response: relatively consistent.


Instruction: Intracerebral, subdural, and subarachnoid bleeds include what?

Output: Intracranial hemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Intracerebral, subdural, and subarachnoid bleeds include what?. ### Response: Intracranial hemorrhage.


Instruction: What types of bleeds are included in the study?

Output: intracerebral, subdural, and subarachnoid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What types of bleeds are included in the study?. ### Response: intracerebral, subdural, and subarachnoid.


Instruction: What did the study report that did not report the number of strokes that were fatal and nonfatal?

Output: CAFA, EAFT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the study report that did not report the number of strokes that were fatal and nonfatal?. ### Response: CAFA, EAFT.


Instruction: How did we estimate the pooled relative risk for stroke across all eligible studies?

Output: imputed values for the number of fatal and nonfatal strokes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did we estimate the pooled relative risk for stroke across all eligible studies?. ### Response: imputed values for the number of fatal and nonfatal strokes.


Instruction: What percentage of nonfatal strokes on no therapy were ischemic?

Output: 98%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of nonfatal strokes on no therapy were ischemic?. ### Response: 98%).


Instruction: How many of the 108 strokes were hemorrhagic?

Output: two (2%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many of the 108 strokes were hemorrhagic?. ### Response: two (2%).


Instruction: How many nonfatal strokes on VKA therapy were ischemic?

Output: 34

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many nonfatal strokes on VKA therapy were ischemic?. ### Response: 34.


Instruction: How many strokes were hemorrhagic?

Output: two (2%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes were hemorrhagic?. ### Response: two (2%).


Instruction: Who published the Guidelines for Prevention of Stroke in Women 1587B?

Output: Bushnell et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the Guidelines for Prevention of Stroke in Women 1587B?. ### Response: Bushnell et al.


Instruction: Who wrote the guidelines for prevention of stroke in women?

Output: Bushnell et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote the guidelines for prevention of stroke in women?. ### Response: Bushnell et al.


Instruction: What is the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology called?

Output: ESC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology called?. ### Response: ESC.


Instruction: What does ESC stand for?

Output: European Society of Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ESC stand for?. ### Response: European Society of Cardiology.


Instruction: How many pages were in Europace in 2010?

Output: 388

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many pages were in Europace in 2010?. ### Response: 388.


Instruction: What is the focus of the 2012 update of the Canadian Cardiovascular Society atrial fibrillation guidelines?

Output: recommendations for stroke prevention and rate/rhythm control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the focus of the 2012 update of the Canadian Cardiovascular Society atrial fibrillation guidelines?. ### Response: recommendations for stroke prevention and rate/rhythm control.


Instruction: What are the recommendations for stroke prevention and rate/rhythm control?

Output: Canadian Cardiovascular Society atrial fibrillation guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the recommendations for stroke prevention and rate/rhythm control?. ### Response: Canadian Cardiovascular Society atrial fibrillation guidelines.


Instruction: What does rate/rhythm control do?

Output: stroke prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does rate/rhythm control do?. ### Response: stroke prevention.


Instruction: What is the name of the journal that published a correction in 2012?

Output: Can J Cardiol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that published a correction in 2012?. ### Response: Can J Cardiol.


Instruction: When was the published correction published?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the published correction published?. ### Response: 2010.


Instruction: What are risk stratification schemes for predicting in patients with atrial fibrillation?

Output: stroke and throm-boembolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are risk stratification schemes for predicting in patients with atrial fibrillation?. ### Response: stroke and throm-boembolism.


Instruction: What is the name of the nationwide cohort study?

Output: Validation of risk stratification schemes for predicting stroke and throm-boembolism in patients with atrial fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the nationwide cohort study?. ### Response: Validation of risk stratification schemes for predicting stroke and throm-boembolism in patients with atrial fibrillation.


Instruction: When was the BMJ's 342:d124?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the BMJ's 342:d124?. ### Response: 2011.


Instruction: Atrial fibrillation to differences in warfarin anticoagulation control (from AFFIRM)?

Output: ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atrial fibrillation to differences in warfarin anticoagulation control (from AFFIRM)?. ### Response: ischemic stroke.


Instruction: Am J Cardiol. 2012;110:1799–1802. 391. Connolly SJ, Eikelboom J, Joyner C, Diener HC, Hart R, Golitsyn S, Flaker G, Avezum A, Hohnloser SH, Diaz R, Pais P, Budaj A, Parkhomenko A, Jansky P, Commerford P,

Output: ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Am J Cardiol. 2012;110:1799–1802. 391. Connolly SJ, Eikelboom J, Joyner C, Diener HC, Hart R, Golitsyn S, Flaker G, Avezum A, Hohnloser SH, Diaz R, Pais P, Budaj A, Parkhomenko A, Jansky P, Commerford P,. ### Response: ischemic stroke.


Instruction: What is the name of the Steering Committee and Investigators for Apixaban in patients?

Output: A VERROES

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Steering Committee and Investigators for Apixaban in patients?. ### Response: A VERROES.


Instruction: A VERROES Steering Committee and Investigators. What is Apixaban in patients with atrial fibrillation?

Output: warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A VERROES Steering Committee and Investigators. What is Apixaban in patients with atrial fibrillation?. ### Response: warfarin.


Instruction: What is the N Engl J Med. 2011:364:806-817?

Output: Apixaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the N Engl J Med. 2011:364:806-817?. ### Response: Apixaban.


Instruction: What is the difference between Apixaban and warfarin?

Output: atrial fibrilla-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between Apixaban and warfarin?. ### Response: atrial fibrilla-tion.


Instruction: What is the difference between apixaban and warfarin in patients with atrial fibrilla-tion?

Output: gender-specific risk of ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between apixaban and warfarin in patients with atrial fibrilla-tion?. ### Response: gender-specific risk of ischemic stroke.


Instruction: What year did N Engl J Med publish 365:981–992?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did N Engl J Med publish 365:981–992?. ### Response: 2011.


Instruction: Who is a member of the ARISTOTLE Committees and Investigators?

Output: Zhu J, Wallentin L

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a member of the ARISTOTLE Committees and Investigators?. ### Response: Zhu J, Wallentin L.


Instruction: What is the difference between Dabigatran and war -farin in patients with atrial fibrillation?

Output: Apixaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between Dabigatran and war -farin in patients with atrial fibrillation?. ### Response: Apixaban.


Instruction: When did N Engl J Med. 2009:361:1139–1151?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did N Engl J Med. 2009:361:1139–1151?. ### Response: 2010.


Instruction: What year did Engl J Med. 2010:363:1877?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Engl J Med. 2010:363:1877?. ### Response: 2009.


Instruction: What was the name of the study that was published in 2009?

Output: N Engl J Med.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the study that was published in 2009?. ### Response: N Engl J Med..


Instruction: How many people were in the 2009 study?

Output: 393

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were in the 2009 study?. ### Response: 393.


Instruction: Who was the author of the 2010 study in 2010?

Output: Bushnell

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the author of the 2010 study in 2010?. ### Response: Bushnell.


Instruction: What are the 2018 Cholesterol Clinical Practice Guidelines?

Output: CLINICAL STATEMENTS  AND GUIDELINESValue Statement: Low Value (LOE: B-NR)6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the 2018 Cholesterol Clinical Practice Guidelines?. ### Response: CLINICAL STATEMENTS  AND GUIDELINESValue Statement: Low Value (LOE: B-NR)6.


Instruction: What is the low cost value of PCSK9 inhibitors compared to the good cost value?

Output: (>$150 000 per QALY

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the low cost value of PCSK9 inhibitors compared to the good cost value?. ### Response: (>$150 000 per QALY.


Instruction: What is the average cost per QALY?

Output: $150 000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the average cost per QALY?. ### Response: $150 000.


Instruction: What section provides a full discussion of the dynamic interaction of different prices and clinical benefit?

Output: Section 7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What section provides a full discussion of the dynamic interaction of different prices and clinical benefit?. ### Response: Section 7.


Instruction: How old is it reasonable to initiate moderate- or high-intensity statin therapy?

Output: 75 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old is it reasonable to initiate moderate- or high-intensity statin therapy?. ### Response: 75 years of age.


Instruction: What is reasonable to initiate in patients older than 75 years of age who are tolerating high-intensity statin therapy?

Output: moderate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable to initiate in patients older than 75 years of age who are tolerating high-intensity statin therapy?. ### Response: moderate.


Instruction: What is another reason to continue high-intensity statin therapy?

Output: clinical ASCVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another reason to continue high-intensity statin therapy?. ### Response: clinical ASCVD.


Instruction: What type of ASCVD risk reduction is considered to be a consideration for patients who are tolerating statins?

Output: high-intensity statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of ASCVD risk reduction is considered to be a consideration for patients who are tolerating statins?. ### Response: high-intensity statin therapy.


Instruction: What is the LDL-C level of patients with ASCVD?

Output: 70 mg/dL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the LDL-C level of patients with ASCVD?. ### Response: 70 mg/dL.


Instruction: What may be reasonable to add ezetimibe.S4.1-15IIb B-R10 in patients with heart failure?

Output: maximally tolerated statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be reasonable to add ezetimibe.S4.1-15IIb B-R10 in patients with heart failure?. ### Response: maximally tolerated statin therapy.


Instruction: What is the life expectancy for patients with ischemic heart disease?

Output: 3 to 5 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the life expectancy for patients with ischemic heart disease?. ### Response: 3 to 5 years.


Instruction: What may clinicians consider to reduce the occurrence of ASCVD events?

Output: initiation of moderate-intensity statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may clinicians consider to reduce the occurrence of ASCVD events?. ### Response: initiation of moderate-intensity statin therapy.


Instruction: What is an example of a cardiac atherosclerotic cardiovascular disease?

Output: aortic aneurysm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a cardiac atherosclerotic cardiovascular disease?. ### Response: aortic aneurysm.


Instruction: What is a medical term for acute coronary syndrome?

Output: atherosclerotic cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a medical term for acute coronary syndrome?. ### Response: atherosclerotic cardiovascular disease.


Instruction: What is aneurysm all of atherosclerotic origin?

Output: aortic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is aneurysm all of atherosclerotic origin?. ### Response: aortic.


Instruction: What encompasses those with history of MI, stable or unstable angina, coronary or other arterial revascularization, stroke, TIA or PAD?

Output: Clinical ASCVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What encompasses those with history of MI, stable or unstable angina, coronary or other arterial revascularization, stroke, TIA or PAD?. ### Response: Clinical ASCVD.


Instruction: Which meta-analysis did the writ-ing group use?

Output: Cholesterol Treatment Tri-alists’ (CTT)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which meta-analysis did the writ-ing group use?. ### Response: Cholesterol Treatment Tri-alists’ (CTT).


Instruction: How many other RCTs have used nonstatin drugs as add-ons to statin therapy?

Output: 4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many other RCTs have used nonstatin drugs as add-ons to statin therapy?. ### Response: 4.


Instruction: What is indicated as a primary recommendation for clinical ASCVD?

Output: high-intensity statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is indicated as a primary recommendation for clinical ASCVD?. ### Response: high-intensity statin therapy.


Instruction: High-intensity statin is indicated for what?

Output: clinical ASCVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: High-intensity statin is indicated for what?. ### Response: clinical ASCVD.


Instruction: What type of statin therapy can be initiated if it cannot be used?

Output: moderate-intensity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of statin therapy can be initiated if it cannot be used?. ### Response: moderate-intensity.


Instruction: What is the first goal of a moderate-intensity statin treatment?

Output: reduce the occurrence of ASCVD events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the first goal of a moderate-intensity statin treatment?. ### Response: reduce the occurrence of ASCVD events.


Instruction: If LDL-C levels remain 70 mg/dL, what may be added?

Output: ezetimibe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: If LDL-C levels remain 70 mg/dL, what may be added?. ### Response: ezetimibe.


Instruction: What is the name of the family-based SKIPOGH study?

Output: PLoS ONE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the family-based SKIPOGH study?. ### Response: PLoS ONE.


Instruction: What are age-specific differences between conventional and ambulatory daytime blood pressure?

Output: 64:1073–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are age-specific differences between conventional and ambulatory daytime blood pressure?. ### Response: 64:1073–.


Instruction: What is white-coat hypertension?

Output: cardiovascular risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is white-coat hypertension?. ### Response: cardiovascular risk.


Instruction: What is the family-based SKIPOGH study?

Output: Epidemiology of masked and white-coat hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the family-based SKIPOGH study?. ### Response: Epidemiology of masked and white-coat hypertension.


Instruction: How does the Masked Hypertension Study compare with left ventricular mass?

Output: diagnostic overlap and interrelationships

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does the Masked Hypertension Study compare with left ventricular mass?. ### Response: diagnostic overlap and interrelationships.


Instruction: What is the cardiovascular risk of white-coat hypertension?

Output: S4.4-25

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cardiovascular risk of white-coat hypertension?. ### Response: S4.4-25.


Instruction: What study did Tientcheu D, Ayers C, Das SR, et al. analyze?

Output: Dallas Heart Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What study did Tientcheu D, Ayers C, Das SR, et al. analyze?. ### Response: Dallas Heart Study.


Instruction: What is the Dallas Heart Study?

Output: Masked Hypertension Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Dallas Heart Study?. ### Response: Masked Hypertension Study.


Instruction: What is a meta-analysis of white-coat hypertension and cardiovascular events?

Output: Pressione Arteriose Monitorate E Loro Associazioni [PAMELA] Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a meta-analysis of white-coat hypertension and cardiovascular events?. ### Response: Pressione Arteriose Monitorate E Loro Associazioni [PAMELA] Study.


Instruction: Who recommended screening adults for high blood pressure?

Output: U.S. Preventive Services Task Force. Screening for high blood pressure in adults: U.S. Preventive Services Task Force

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who recommended screening adults for high blood pressure?. ### Response: U.S. Preventive Services Task Force. Screening for high blood pressure in adults: U.S. Preventive Services Task Force.


Instruction: Blood pressure in adults: U.S. Preventive Services Task Force recommendation statement.

Output: Siu AL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Blood pressure in adults: U.S. Preventive Services Task Force recommendation statement.. ### Response: Siu AL.


Instruction: What is the name of the recommendation statement?

Output: U.S. Preventive Services Task Force

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the recommendation statement?. ### Response: U.S. Preventive Services Task Force.


Instruction: Blood Press Monit. 2006;11:47–52.

Output: Home blood pressure self-moni-toring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Blood Press Monit. 2006;11:47–52.. ### Response: Home blood pressure self-moni-toring.


Instruction: What does Nasothimiou EG, Tzamouranis D, Rarra V, et al. do?

Output: Diagnostic accu-racy of home vs. ambulatory blood pressure monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Nasothimiou EG, Tzamouranis D, Rarra V, et al. do?. ### Response: Diagnostic accu-racy of home vs. ambulatory blood pressure monitoring.


Instruction: What is the difference between home and ambulatory blood pressure monitoring?

Output: Diagnostic accu-racy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between home and ambulatory blood pressure monitoring?. ### Response: Diagnostic accu-racy.


Instruction: Hypertens Res. 2012;35:750-5. S4.4-30. Sega R, Trocino G, Lanzarotti A, and others. Alterations of cardiac struc-ture in patients with what type of hypertension?

Output: isolated office, ambulatory, or home hyper -tension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hypertens Res. 2012;35:750-5. S4.4-30. Sega R, Trocino G, Lanzarotti A, and others. Alterations of cardiac struc-ture in patients with what type of hypertension?. ### Response: isolated office, ambulatory, or home hyper -tension.


Instruction: What is the name of the PAMELA Study?

Output: Pressione Arteriose Monitorate E Loro Associazioni

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the PAMELA Study?. ### Response: Pressione Arteriose Monitorate E Loro Associazioni.


Instruction: How many people were included in the meta-analysis?

Output: 7 030

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were included in the meta-analysis?. ### Response: 7 030.


Instruction: What type of ambulatory blood pressure is better than daytime?

Output: conventional

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of ambulatory blood pressure is better than daytime?. ### Response: conventional.


Instruction: How many people were included in a meta-analysis of conventional blood pressure in four populations?

Output: 7 030

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were included in a meta-analysis of conventional blood pressure in four populations?. ### Response: 7 030.


Instruction: What is the name of the study that examined the prevalence, determi-nants, and clinical significance of masked hypertension in African Americans?

Output: Jackson Heart Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined the prevalence, determi-nants, and clinical significance of masked hypertension in African Americans?. ### Response: Jackson Heart Study.


Instruction: What is the name of the study that examined masked hypertension in hypertensive patients treated in a primary care setting?

Output: Ohasama study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined masked hypertension in hypertensive patients treated in a primary care setting?. ### Response: Ohasama study.


Instruction: What did the Ohasama study show about hypertension in Japan?

Output: Masked hypertension determined by self-measured blood pressure at home and chronic kidney disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Ohasama study show about hypertension in Japan?. ### Response: Masked hypertension determined by self-measured blood pressure at home and chronic kidney disease.


Instruction: What was the name of the study that found masked hypertension and chronic kidney disease in the Japanese population?

Output: Ohasama study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the study that found masked hypertension and chronic kidney disease in the Japanese population?. ### Response: Ohasama study.


Instruction: What is the name of the 2013 ACCF/AHA STEMI Guideline?

Output: O’Gara et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2013 ACCF/AHA STEMI Guideline?. ### Response: O’Gara et al.


Instruction: What are some potential complications of primary PCI?

Output: problems with the arterial access site; adverse reactions to volume loading, contrast medium, and antithrombotic medications; technical complications; and reperfusion events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some potential complications of primary PCI?. ### Response: problems with the arterial access site; adverse reactions to volume loading, contrast medium, and antithrombotic medications; technical complications; and reperfusion events.


Instruction: What causes suboptimal myocardial perfu-sion despite restoration of epicardial flow in the infarct artery?

Output: no-reflow

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes suboptimal myocardial perfu-sion despite restoration of epicardial flow in the infarct artery?. ### Response: no-reflow.


Instruction: What is associated with reduced survival rate?

Output: No-reflow

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with reduced survival rate?. ### Response: No-reflow.


Instruction: What is the GP IIb/IIIa antagonist abciximab used for?

Output: Treatment and prevention strategies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the GP IIb/IIIa antagonist abciximab used for?. ### Response: Treatment and prevention strategies.


Instruction: What are vasodilators?

Output: nitroprusside, vera-pamil, adenosine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are vasodilators?. ### Response: nitroprusside, vera-pamil, adenosine.


Instruction: How does manual thrombus aspiration improve tissue perfusion?

Output: more complete ST resolution

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does manual thrombus aspiration improve tissue perfusion?. ### Response: more complete ST resolution.


Instruction: What has improved tissue perfusion and more complete ST resolution?

Output: Manual thrombus aspiration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has improved tissue perfusion and more complete ST resolution?. ### Response: Manual thrombus aspiration.


Instruction: What has not all studies shown positive results?

Output: Manual thrombus aspiration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has not all studies shown positive results?. ### Response: Manual thrombus aspiration.


Instruction: What is not recom-mended in this context unless multiple complex lesions are seen on angiography and ECG localization of the infarct is ambiguous?

Output: Noninfarct artery PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recom-mended in this context unless multiple complex lesions are seen on angiography and ECG localization of the infarct is ambiguous?. ### Response: Noninfarct artery PCI.


Instruction: Clinical stability may be defined broadly as what?

Output: the absence of low output, hypotension, persistent tachycar -dia, apparent shock, high-grade ventricular or symptomatic supraventricular tachyarrhythmias, and spontaneous recurrent ischemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Clinical stability may be defined broadly as what?. ### Response: the absence of low output, hypotension, persistent tachycar -dia, apparent shock, high-grade ventricular or symptomatic supraventricular tachyarrhythmias, and spontaneous recurrent ischemia.


Instruction: What is ambiguous?

Output: ECG localization of the infarct

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ambiguous?. ### Response: ECG localization of the infarct.


Instruction: Clinical stability may be defined broadly as the absence of low output, hypotension, persistent tachycar -dia, apparent shock, high-grade ventricular or symptomatic supraventricular techyarrhythmias, and what else?

Output: spontaneous recurrent ischemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Clinical stability may be defined broadly as the absence of low output, hypotension, persistent tachycar -dia, apparent shock, high-grade ventricular or symptomatic supraventricular techyarrhythmias, and what else?. ### Response: spontaneous recurrent ischemia.


Instruction: What might improve hemodynamic stability in a large noninfarct artery?

Output: PCI of a severe stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What might improve hemodynamic stability in a large noninfarct artery?. ### Response: PCI of a severe stenosis.


Instruction: What should be considered dur ing the primary procedure?

Output: PCI of a severe stenosis in a large noninfarct artery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered dur ing the primary procedure?. ### Response: PCI of a severe stenosis in a large noninfarct artery.


Instruction: In the majority of patients, delayed PCI can be performed at a later time?

Output: if indicated by clinical events or the results of noninvasive testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the majority of patients, delayed PCI can be performed at a later time?. ### Response: if indicated by clinical events or the results of noninvasive testing.


Instruction: What is reasonable for patients undergoing primary PCI?

Output: Manual aspiration thrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable for patients undergoing primary PCI?. ### Response: Manual aspiration thrombectomy.


Instruction: How many RCTs and a meta-analysis support the use of man-ual aspiration thrombectomy?

Output: Two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs and a meta-analysis support the use of man-ual aspiration thrombectomy?. ### Response: Two.


Instruction: What is the purpose of aspiration thrombectomy during PCI?

Output: to improve microvascular reperfusion and to decrease deaths and adverse cardiac events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of aspiration thrombectomy during PCI?. ### Response: to improve microvascular reperfusion and to decrease deaths and adverse cardiac events.


Instruction: What did the INFUSE-AMI trial show?

Output: The trial was underpowered to detect differences in clinical outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the INFUSE-AMI trial show?. ### Response: The trial was underpowered to detect differences in clinical outcomes.


Instruction: What is the name of the Coronary Intervention for Anterior ST-Segment Elevation Myocardial Infarction trial?

Output: INFUSE-AMI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Coronary Intervention for Anterior ST-Segment Elevation Myocardial Infarction trial?. ### Response: INFUSE-AMI.


Instruction: What was the trial underpowered to detect?

Output: differences in clinical outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the trial underpowered to detect?. ### Response: differences in clinical outcomes.


Instruction: What is the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al.


Instruction: What is ideally located at centers with immediate access to cardiac surgery during the initial observation stages of the disease?

Output: CLINICAL STATEMENTS  AND GUIDELINESmodalities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ideally located at centers with immediate access to cardiac surgery during the initial observation stages of the disease?. ### Response: CLINICAL STATEMENTS  AND GUIDELINESmodalities.


Instruction: What may be rea-sonable to manage patients with lower-acuity IE in a center without on-site multispecialty care?

Output: telemedicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be rea-sonable to manage patients with lower-acuity IE in a center without on-site multispecialty care?. ### Response: telemedicine.


Instruction: What is the emerging use of telemedicine?

Output: it may be rea-sonable to manage patients with lower-acuity IE in a center without on-site multispecialty care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the emerging use of telemedicine?. ### Response: it may be rea-sonable to manage patients with lower-acuity IE in a center without on-site multispecialty care.


Instruction: What is a major criterion in the diagnosis of IE?

Output: The presence of valvular vegetation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a major criterion in the diagnosis of IE?. ### Response: The presence of valvular vegetation.


Instruction: What has a sen-sitivity between 50% and 90%?

Output: TTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has a sen-sitivity between 50% and 90%?. ### Response: TTE.