Instruction: Who published the 2018 Cholesterol Clinical Practice Guidelines?

Output: Grundy et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2018 Cholesterol Clinical Practice Guidelines?. ### Response: Grundy et al.


Instruction: What is the required information for the 2018 CHOLOSTERO Clinical Practice Guidelines?

Output: age, sex, and race/ethnicity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the required information for the 2018 CHOLOSTERO Clinical Practice Guidelines?. ### Response: age, sex, and race/ethnicity.


Instruction: What does the PCE include?

Output: a stroke endpoint and race-specific coefficients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the PCE include?. ### Response: a stroke endpoint and race-specific coefficients.


Instruction: What is a race-specific coefficient?

Output: a black woman who with similar risk factors is at much higher risk than her white counterpart

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a race-specific coefficient?. ### Response: a black woman who with similar risk factors is at much higher risk than her white counterpart.


Instruction: Where were the tests externally validated?

Output: a high-qual-ity natural history study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where were the tests externally validated?. ### Response: a high-qual-ity natural history study.


Instruction: When were the PCE externally validated?

Output: shortly after the 2013 ACC/AHA cholesterol guidelines were presented

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When were the PCE externally validated?. ### Response: shortly after the 2013 ACC/AHA cholesterol guidelines were presented.


Instruction: What may underestimate risk in individuals of South Asian ancestry and other high-risk groups?

Output: equations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may underestimate risk in individuals of South Asian ancestry and other high-risk groups?. ### Response: equations.


Instruction: What type of endpoints does the PCE use?

Output: fatal and nonfatal stroke and CHD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of endpoints does the PCE use?. ### Response: fatal and nonfatal stroke and CHD.


Instruction: What other risk estimators provide risk estimates that can't be compared directly with those given by PCE?

Output: revascularization and additional cardiovascular endpoints

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What other risk estimators provide risk estimates that can't be compared directly with those given by PCE?. ### Response: revascularization and additional cardiovascular endpoints.


Instruction: In addition to revascularization, what other endpoint provides risk estimates?

Output: cardiovascular

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In addition to revascularization, what other endpoint provides risk estimates?. ### Response: cardiovascular.


Instruction: What can be reviewed in the clinician-patient risk discussion?

Output: the potential for errors in estimating ASCVD risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be reviewed in the clinician-patient risk discussion?. ### Response: the potential for errors in estimating ASCVD risk.


Instruction: The present guidelines continue to emphasize the importance of what?

Output: clinician–patient risk discussion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The present guidelines continue to emphasize the importance of what?. ### Response: clinician–patient risk discussion.


Instruction: What does the 2013 ACC/AHA cholesterol guidelines recommend?

Output: frank discussion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the 2013 ACC/AHA cholesterol guidelines recommend?. ### Response: frank discussion.


Instruction: What should a clinician-patient risk discussion consider?

Output: whether ASCVD risk factors have been addressed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should a clinician-patient risk discussion consider?. ### Response: whether ASCVD risk factors have been addressed.


Instruction: What should the 2013 ACC/AHA cholesterol guidelines consider?

Output: whether ASCVD risk factors have been addressed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should the 2013 ACC/AHA cholesterol guidelines consider?. ### Response: whether ASCVD risk factors have been addressed.


Instruction: What should be considered in the 2013 cholesterol guidelines?

Output: frank discussion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered in the 2013 cholesterol guidelines?. ### Response: frank discussion.


Instruction: How should the cholesterol guidelines be evaluated?

Output: frank discussion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How should the cholesterol guidelines be evaluated?. ### Response: frank discussion.


Instruction: How can a risk decision about statin therapy be made?

Output: on the basis of individual characteristics and including an informed patient preference in shared decision-making

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can a risk decision about statin therapy be made?. ### Response: on the basis of individual characteristics and including an informed patient preference in shared decision-making.


Instruction: As ASCVD risk increases, so does benefit of evidence-based LDL-C-lower-ing therapy?

Output: Clinicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: As ASCVD risk increases, so does benefit of evidence-based LDL-C-lower-ing therapy?. ### Response: Clinicians.


Instruction: What can be used to clarify risk for those at intermediate-risk?

Output: risk-enhancing factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be used to clarify risk for those at intermediate-risk?. ### Response: risk-enhancing factors.


Instruction: What are CACs?

Output: risk-enhancing factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are CACs?. ### Response: risk-enhancing factors.


Instruction: What can be used to clarify risk if the risk decision is uncertain?

Output: risk-enhancing factors or CAC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be used to clarify risk if the risk decision is uncertain?. ### Response: risk-enhancing factors or CAC.


Instruction: What are some risk-enhancing factors?

Output: CAC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some risk-enhancing factors?. ### Response: CAC.


Instruction: How many mg/dL of LDL-C are there in Table 7?

Output: 189

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mg/dL of LDL-C are there in Table 7?. ### Response: 189.


Instruction: What did the Framingham study show about alcohol consumption and risk of atrial fibrillation?

Output: Long-term

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Framingham study show about alcohol consumption and risk of atrial fibrillation?. ### Response: Long-term.


Instruction: What was the name of the 2008 study that examined alcohol consumption in relation to risk of a heart attack?

Output: ARIC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the 2008 study that examined alcohol consumption in relation to risk of a heart attack?. ### Response: ARIC.


Instruction: When was the Am J Cardiol 200493:710-713?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Am J Cardiol 200493:710-713?. ### Response: 2004.


Instruction: What reduces the risk of ischemic stroke?

Output: Moderate alcohol consumption

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What reduces the risk of ischemic stroke?. ### Response: Moderate alcohol consumption.


Instruction: What is the name of the study that found that moderate alcohol consumption reduces risk?

Output: Northern Manhattan Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that found that moderate alcohol consumption reduces risk?. ### Response: Northern Manhattan Study.


Instruction: How many people were involved in the Northern Manhattan Study?

Output: 670

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were involved in the Northern Manhattan Study?. ### Response: 670.


Instruction: How many urban medical centers were involved in a case-control study?

Output: three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many urban medical centers were involved in a case-control study?. ### Response: three.


Instruction: What is the name of the study that examined the effects of cigarette smoking on the risk of stroke?

Output: Northern Manhattan Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined the effects of cigarette smoking on the risk of stroke?. ### Response: Northern Manhattan Study.


Instruction: Where was the study conducted?

Output: Chicago, Illinois

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where was the study conducted?. ### Response: Chicago, Illinois.


Instruction: What does alcohol consumption and risk of stroke among mid-dle-aged men: the JPHC Study Cohort I. Stroke. 2004;35:1124–1129. 672.

Output: JPHC Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does alcohol consumption and risk of stroke among mid-dle-aged men: the JPHC Study Cohort I. Stroke. 2004;35:1124–1129. 672.. ### Response: JPHC Study Group.


Instruction: What is the name of the study cohort that studied alcohol consumption among middle age men?

Output: JPHC Study Cohort I

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study cohort that studied alcohol consumption among middle age men?. ### Response: JPHC Study Cohort I.


Instruction: What type of alcohol intake is associated with the risk of cerebral infarction in young women?

Output: Drinking frequency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of alcohol intake is associated with the risk of cerebral infarction in young women?. ### Response: Drinking frequency.


Instruction: When did Stroke. 2001;32:77-83?

Output: 673

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Stroke. 2001;32:77-83?. ### Response: 673.


Instruction: What is the protective effect of moderate alcohol consumption on?

Output: ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the protective effect of moderate alcohol consumption on?. ### Response: ischemic stroke.


Instruction: What is the protective effect of moderate alcohol consumption on ischemic stroke?

Output: reduces risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the protective effect of moderate alcohol consumption on ischemic stroke?. ### Response: reduces risk.


Instruction: When did JAMA publish its 281:53-60?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did JAMA publish its 281:53-60?. ### Response: 1999.


Instruction: What was the name of the prospective study that examined alcohol consumption and risk of coro-nary disease and stroke in women?

Output: ARIC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the prospective study that examined alcohol consumption and risk of coro-nary disease and stroke in women?. ### Response: ARIC.


Instruction: What does alcohol consumption and risk of stroke in women do?

Output: moderate alcohol consumption and the risk of coro-nary disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does alcohol consumption and risk of stroke in women do?. ### Response: moderate alcohol consumption and the risk of coro-nary disease.


Instruction: What does Stroke. 2012:43:939-945?

Output: Alcohol consumption and risk of stroke in women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Stroke. 2012:43:939-945?. ### Response: Alcohol consumption and risk of stroke in women.


Instruction: How many women were diagnosed with stroke in 1988?

Output: 675

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many women were diagnosed with stroke in 1988?. ### Response: 675.


Instruction: What is a risk factor for cardiovascular disease among hypertensive women?

Output: Alcohol consumption

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for cardiovascular disease among hypertensive women?. ### Response: Alcohol consumption.


Instruction: What is the name of the journal that studies the relationship between alcohol consumption and risk of cardiovascular disease?

Output: Framingham

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies the relationship between alcohol consumption and risk of cardiovascular disease?. ### Response: Framingham.


Instruction: In what year did Neuroepidemiology publish a study on alcohol consumption?

Output: 1989

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did Neuroepidemiology publish a study on alcohol consumption?. ### Response: 1989.


Instruction: What is a meta-analysis of alcohol con-sumption and risk of stroke?

Output: JPHC Study Cohort I. Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a meta-analysis of alcohol con-sumption and risk of stroke?. ### Response: JPHC Study Cohort I. Stroke.


Instruction: What is the name of the journal that published a study on the association between alcohol consumption and stroke risk?

Output: JAMA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that published a study on the association between alcohol consumption and stroke risk?. ### Response: JAMA.


Instruction: In what year was the Journal of Ambulatory Medicine published?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was the Journal of Ambulatory Medicine published?. ### Response: 1999.


Instruction: What is hemorrhage: characteristics and effect on outcome?

Output: moderate alcohol consumption

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hemorrhage: characteristics and effect on outcome?. ### Response: moderate alcohol consumption.


Instruction: What is drinking frequency, mediating biomarkers, and risk of myocardial infarction in women and men?

Output: Alcohol intake

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is drinking frequency, mediating biomarkers, and risk of myocardial infarction in women and men?. ### Response: Alcohol intake.


Instruction: What does alcohol consumption and type of alcoholic beverage con-sume with?

Output: plasma lipid levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does alcohol consumption and type of alcoholic beverage con-sume with?. ### Response: plasma lipid levels.


Instruction: What is the difference between Whites and African Americans of the ARIC study?

Output: Relationship of alcohol consumption and type of alcoholic beverage con-sumed with plasma lipid levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between Whites and African Americans of the ARIC study?. ### Response: Relationship of alcohol consumption and type of alcoholic beverage con-sumed with plasma lipid levels.


Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020 Page 54 of 127 mortality?

Output: federal recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020 Page 54 of 127 mortality?. ### Response: federal recommendations.


Instruction: What was associated with a 20% reduction in CV and all-cause mortality compared to no leisure time activity?

Output: Leisure time activity levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with a 20% reduction in CV and all-cause mortality compared to no leisure time activity?. ### Response: Leisure time activity levels.


Instruction: What percentage reduction in all-cause mortality was associated with activity three to five times the recommended level?

Output: 39%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage reduction in all-cause mortality was associated with activity three to five times the recommended level?. ### Response: 39%.


Instruction: What was the reduction in CV mortality associated with?

Output: light leisure time physical activ ity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the reduction in CV mortality associated with?. ### Response: light leisure time physical activ ity.


Instruction: How many times the recommendation level was related to activity 3 to 5 times?

Output: three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many times the recommendation level was related to activity 3 to 5 times?. ### Response: three.


Instruction: The dose -response curve demonstrated an upper limit of benefit at what time?

Output: three to five times recommended levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The dose -response curve demonstrated an upper limit of benefit at what time?. ### Response: three to five times recommended levels.


Instruction: What is the upper limit of benefit at three to five times recommended levels?

Output: dose -response curve demonstrated an upper limit of benefit at three to five times recommended levels, suggesting a ceiling effect on leisure time physical activity benefits

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the upper limit of benefit at three to five times recommended levels?. ### Response: dose -response curve demonstrated an upper limit of benefit at three to five times recommended levels, suggesting a ceiling effect on leisure time physical activity benefits.


Instruction: Evidence indicates a benefit to activity levels much lower than what?

Output: federal recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Evidence indicates a benefit to activity levels much lower than what?. ### Response: federal recommendations.


Instruction: What did Chastin et al. 2017 show?

Output: 29% reduction in all- cause mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Chastin et al. 2017 show?. ### Response: 29% reduction in all- cause mortality.


Instruction: What was the reduction in all cause mortality in primary prevention patients?

Output: 29%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the reduction in all cause mortality in primary prevention patients?. ### Response: 29%.


Instruction: How much time was reduced by LIPA?

Output: 2 – 4 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much time was reduced by LIPA?. ### Response: 2 – 4 hours.


Instruction: What are METs?

Output: metabolic equivalent of task

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are METs?. ### Response: metabolic equivalent of task.


Instruction: How much faster is a MET than a treadmill?

Output: 2 mph

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much faster is a MET than a treadmill?. ### Response: 2 mph.


Instruction: In what study did Schnohr and colleagues follow 12,000 primary prevention patients?

Output: Copenhagen City Heart Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what study did Schnohr and colleagues follow 12,000 primary prevention patients?. ### Response: Copenhagen City Heart Study.


Instruction: How many primary prevention patients were studied for over 30 years?

Output: over 12,000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many primary prevention patients were studied for over 30 years?. ### Response: over 12,000.


Instruction: What was the reduction in CV mortality found in patients persistently at light leisure time physical activity?

Output: 24%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the reduction in CV mortality found in patients persistently at light leisure time physical activity?. ### Response: 24%.


Instruction: How many hours LIPA per week were found in persistently sedentary patients?

Output: (<2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many hours LIPA per week were found in persistently sedentary patients?. ### Response: (<2.


Instruction: How many times a week did LIPA occur?

Output: 2 – 4 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many times a week did LIPA occur?. ### Response: 2 – 4 hours.


Instruction: What did the Work Group not report about safety?

Output: outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Work Group not report about safety?. ### Response: outcomes.


Instruction: What did the Work Group recognize musculoskeletal injuries are not uncommon during exercise?

Output: Safety outcomes were not reported

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Work Group recognize musculoskeletal injuries are not uncommon during exercise?. ### Response: Safety outcomes were not reported.


Instruction: The Work Group determined the available body of evidence ha d significant what?

Output: methodologic limitations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The Work Group determined the available body of evidence ha d significant what?. ### Response: methodologic limitations.


Instruction: What was not reported?

Output: Safety outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not reported?. ### Response: Safety outcomes.


Instruction: What could have impacted outcomes in large prospective cohorts?

Output: imbalance in unmeasured CV prognostic variables

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could have impacted outcomes in large prospective cohorts?. ### Response: imbalance in unmeasured CV prognostic variables.


Instruction: What type of bias did many studies utilize?

Output: self- reported physical activity levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of bias did many studies utilize?. ### Response: self- reported physical activity levels.


Instruction: What is the body of evidence on the CVD benefits of exercise?

Output: a positive association of high magnitude

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the body of evidence on the CVD benefits of exercise?. ### Response: a positive association of high magnitude.


Instruction: What was consistently demonstrated across large studies?

Output: positive association of high magnitude

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was consistently demonstrated across large studies?. ### Response: positive association of high magnitude.


Instruction: Positive effects were found on important patient outcomes in a dose-response relationship?

Output: any movement in daily living during their leisure time might have beneficial effects on CV and all- cause mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Positive effects were found on important patient outcomes in a dose-response relationship?. ### Response: any movement in daily living during their leisure time might have beneficial effects on CV and all- cause mortality.


Instruction: What is the name of the guideline for the secondary prevention of ischemic stroke?

Output: Guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the guideline for the secondary prevention of ischemic stroke?. ### Response: Guideline.


Instruction: What does secondary stroke prevention influence by influencing patient behaviors?

Output: vascular risk factor treatment and control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does secondary stroke prevention influence by influencing patient behaviors?. ### Response: vascular risk factor treatment and control.


Instruction: What are multicomponent interventions that fit into categories defined by Wensing et al829?

Output: secondary stroke prevention as those that influence vascular risk factor treatment and control by influencing provider or patient behaviors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are multicomponent interventions that fit into categories defined by Wensing et al829?. ### Response: secondary stroke prevention as those that influence vascular risk factor treatment and control by influencing provider or patient behaviors.


Instruction: What are interventions that involve revision of pro-fessional roles, collaboration between multidisciplinary teams, integrated care services, and knowledge management systems?

Output: Cat-egories

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are interventions that involve revision of pro-fessional roles, collaboration between multidisciplinary teams, integrated care services, and knowledge management systems?. ### Response: Cat-egories.


Instruction: What do we review best available data for?

Output: revision of pro-fessional roles, collaboration between multidisciplinary teams, integrated care services, knowledge management systems, and quality management systems

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do we review best available data for?. ### Response: revision of pro-fessional roles, collaboration between multidisciplinary teams, integrated care services, knowledge management systems, and quality management systems.


Instruction: What may affect the generalizability of findings?

Output: the study setting, patient access to care after an acute stroke, and other patient demographic characteristics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may affect the generalizability of findings?. ### Response: the study setting, patient access to care after an acute stroke, and other patient demographic characteristics.


Instruction: What is affect by health system level, hospital-level, provider-level and patient- and community-specific factors?

Output: Adherence to evidence-based guidelines for secondary stroke prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is affect by health system level, hospital-level, provider-level and patient- and community-specific factors?. ### Response: Adherence to evidence-based guidelines for secondary stroke prevention.


Instruction: Regular hospital and outpatient-based programs for adherence and risk factor monitoring provide the oppor-tunity to identify areas of need?

Output: to optimize strategies to improve care quality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Regular hospital and outpatient-based programs for adherence and risk factor monitoring provide the oppor-tunity to identify areas of need?. ### Response: to optimize strategies to improve care quality.


Instruction: What is an example of an inpatient registry used for quality monitoring and improvement?

Output: The Get With The Guidelines registry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of an inpatient registry used for quality monitoring and improvement?. ### Response: The Get With The Guidelines registry.


Instruction: What is an inpatient registry used for?

Output: quality monitoring and improvement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an inpatient registry used for?. ### Response: quality monitoring and improvement.


Instruction: What may be beneficial for risk factor control and secondary prevention after ischemic stroke and TIA?

Output: Interventions that include a multidisciplinary team–based approach to care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be beneficial for risk factor control and secondary prevention after ischemic stroke and TIA?. ### Response: Interventions that include a multidisciplinary team–based approach to care.


Instruction: Where was the ICARUSS study conducted?

Output: Australia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where was the ICARUSS study conducted?. ### Response: Australia.


Instruction: In what country was the Reduction of Secondary Stroke conducted?

Output: Australia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what country was the Reduction of Secondary Stroke conducted?. ### Response: Australia.


Instruction: What was associated with a significant decrease in SBP at 12 months compared with usual care?

Output: care model intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with a significant decrease in SBP at 12 months compared with usual care?. ### Response: care model intervention.


Instruction: What study showed significant benefit for BP lowering when nurses or pharmacists were involved in BP man-agement?

Output: NAILED Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What study showed significant benefit for BP lowering when nurses or pharmacists were involved in BP man-agement?. ### Response: NAILED Stroke.


Instruction: What did investigators test in the SUSTAIN study?

Output: an intervention that included a nurse prac-titioner/physician assistant care manager, group clinics, self-management support, and care coordi-nation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did investigators test in the SUSTAIN study?. ### Response: an intervention that included a nurse prac-titioner/physician assistant care manager, group clinics, self-management support, and care coordi-nation.


Instruction: What is a systemic use of stroke averting interventions?

Output: SUSTAIN study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a systemic use of stroke averting interventions?. ### Response: SUSTAIN study.


Instruction: What did investigators test to enhance risk factor control?

Output: an intervention that included a nurse prac-titioner/physician assistant care manager, group clinics, self-management support, and care coordi-nation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did investigators test to enhance risk factor control?. ### Response: an intervention that included a nurse prac-titioner/physician assistant care manager, group clinics, self-management support, and care coordi-nation.


Instruction: What group was more likely to achieve LDL goals than the usual care group?

Output: intervention group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What group was more likely to achieve LDL goals than the usual care group?. ### Response: intervention group.


Instruction: Based Clinical Practice Guidelines. Chest. 2012;141:e531S–575S.

Output: 381

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Based Clinical Practice Guidelines. Chest. 2012;141:e531S–575S.. ### Response: 381.


Instruction: A novel user-friendly score to assess 1-year risk of major bleeding in patients with atrial fibrillation?

Output: HAS-BLED

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A novel user-friendly score to assess 1-year risk of major bleeding in patients with atrial fibrillation?. ### Response: HAS-BLED.


Instruction: What is the Euro Heart Survey?

Output: A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Euro Heart Survey?. ### Response: A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation.


Instruction: What are the three risk-prediction scores in patients with atrial fibrillation undergoing anticoagulation?

Output: R(2)HAGES, ATRIA, and HAS-BLED bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the three risk-prediction scores in patients with atrial fibrillation undergoing anticoagulation?. ### Response: R(2)HAGES, ATRIA, and HAS-BLED bleeding.


Instruction: What is the name of the SR34006 compared to Warfarin or Acenocoumarol in Patients With Atrial Fibrillation study?

Output: AMADEUS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the SR34006 compared to Warfarin or Acenocoumarol in Patients With Atrial Fibrillation study?. ### Response: AMADEUS.


Instruction: When was the J Am Coll Cardiol.60:861-867?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol.60:861-867?. ### Response: 2012.


Instruction: What was the outcome of the community-based cohort study in patients with atrial fibrillation?

Output: Prognosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome of the community-based cohort study in patients with atrial fibrillation?. ### Response: Prognosis.


Instruction: What was the CHA2DS2-V ASc Score=0 in a community-based cohort study?

Output: Prognosis in patients with atrial fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the CHA2DS2-V ASc Score=0 in a community-based cohort study?. ### Response: Prognosis in patients with atrial fibrillation.


Instruction: What is the name of the new risk scheme to predict warfarin-associated hem-orrhage?

Output: ATRIA (Anticoagulation and Risk Factors in Atrial Fibrillation) Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the new risk scheme to predict warfarin-associated hem-orrhage?. ### Response: ATRIA (Anticoagulation and Risk Factors in Atrial Fibrillation) Study.


Instruction: What is the name of the study that looked at the risk factors in atrial fibrillation?

Output: AMADEUS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that looked at the risk factors in atrial fibrillation?. ### Response: AMADEUS.


Instruction: What is a meta-analysis of antithrombotic therapy to prevent stroke in patients with nonvalvular atrial fibrosis?

Output: an observational study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a meta-analysis of antithrombotic therapy to prevent stroke in patients with nonvalvular atrial fibrosis?. ### Response: an observational study.


Instruction: How many patients were enrolled in the 2011 J Am Coll Cardiol study?

Output: 385

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were enrolled in the 2011 J Am Coll Cardiol study?. ### Response: 385.


Instruction: What was reduced poststroke mortality in patients with stroke and atrial fibrillation treated with anticoagulants?

Output: results from a Danish quality-control registry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was reduced poststroke mortality in patients with stroke and atrial fibrillation treated with anticoagulants?. ### Response: results from a Danish quality-control registry.


Instruction: How many patients with ischemic stroke were enrolled in the Danish quality-control registry?

Output: 22,179

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with ischemic stroke were enrolled in the Danish quality-control registry?. ### Response: 22,179.


Instruction: What is the name of the study that found a reduction in post stroke mortality?

Output: Danish quality-control registry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that found a reduction in post stroke mortality?. ### Response: Danish quality-control registry.


Instruction: What is the effect of oral anticoagulation on stroke severity and mortality in atrial fibrillation?

Output: Effect of intensity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of oral anticoagulation on stroke severity and mortality in atrial fibrillation?. ### Response: Effect of intensity.


Instruction: What was the N Engl J Med 2003 349:1019-1026?

Output: Effect of intensity of oral anticoagulation on stroke severity and mortality in atrial fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the N Engl J Med 2003 349:1019-1026?. ### Response: Effect of intensity of oral anticoagulation on stroke severity and mortality in atrial fibrillation.


Instruction: Who are the Investigators of the Registry of the Canadian Stroke Network?

Output: O’Donnell M, Oczkowski W, Fang J, Kearon C, Silva J, Bradley C, Guyatt G, Gould L, D’Uva C, Kapral M, Silver F

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who are the Investigators of the Registry of the Canadian Stroke Network?. ### Response: O’Donnell M, Oczkowski W, Fang J, Kearon C, Silva J, Bradley C, Guyatt G, Gould L, D’Uva C, Kapral M, Silver F.


Instruction: What is the name of the observational study that looked at stroke severity in patients with atrial fibrillation and acute ischaemic stroke?

Output: Preadmission antithrombotic treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the observational study that looked at stroke severity in patients with atrial fibrillation and acute ischaemic stroke?. ### Response: Preadmission antithrombotic treatment.


Instruction: What is the Birmingham Atrial Fibrillation Treatment of the Aged Study known as?

Output: BAFTA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Birmingham Atrial Fibrillation Treatment of the Aged Study known as?. ### Response: BAFTA.


Instruction: Which drug is used for stroke prevention in an elderly community population with atrial fibrillation?

Output: Warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which drug is used for stroke prevention in an elderly community population with atrial fibrillation?. ### Response: Warfarin.


Instruction: What is BAFTA?

Output: Birmingham Atrial Fibrillation Treatment of the Aged Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is BAFTA?. ### Response: Birmingham Atrial Fibrillation Treatment of the Aged Study.


Instruction: What is the Aged Study called?

Output: Birmingham Atrial Fibrillation Treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Aged Study called?. ### Response: Birmingham Atrial Fibrillation Treatment.


Instruction: When was the aged study published?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the aged study published?. ### Response: 2007.


Instruction: Who is on behalf of the American Heart Association?

Output: Stroke Council

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is on behalf of the American Heart Association?. ### Response: Stroke Council.


Instruction: What does Care and Outcomes Research stand for?

Output: Council on Quality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Care and Outcomes Research stand for?. ### Response: Council on Quality.


Instruction: What does Council on Clinical Cardiology stand for for the prevention of?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Council on Clinical Cardiology stand for for the prevention of?. ### Response: stroke.


Instruction: Infarction rates and cardiovascular risk factors among patients with what disease?

Output: human immunodeficiency virus disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Infarction rates and cardiovascular risk factors among patients with what disease?. ### Response: human immunodeficiency virus disease.


Instruction: In what year did J Clin Endocrinol Metab. 2007:92:2506-12?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did J Clin Endocrinol Metab. 2007:92:2506-12?. ### Response: 2007.


Instruction: What is the missing link in HIV-1-associated atherosclerosis?

Output: unraveling

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the missing link in HIV-1-associated atherosclerosis?. ### Response: unraveling.


Instruction: What causes cardiovascular and type 2 diabetes morbidity and all-cause mortality among diverse chronic inflammatory disorders?

Output: infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes cardiovascular and type 2 diabetes morbidity and all-cause mortality among diverse chronic inflammatory disorders?. ### Response: infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease.


Instruction: What does hepatitis C virus coinfection independently increase the risk of?

Output: cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does hepatitis C virus coinfection independently increase the risk of?. ### Response: cardiovascular disease.


Instruction: What is the risk of cardiovascular disease in HIV-positive patients?

Output: Hepatitis C virus coinfection independently increases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of cardiovascular disease in HIV-positive patients?. ### Response: Hepatitis C virus coinfection independently increases.


Instruction: What is low frequency of primary lipid screening among medicare patients with rheumatoid arthritis?

Output: S4.5.5-14

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is low frequency of primary lipid screening among medicare patients with rheumatoid arthritis?. ### Response: S4.5.5-14.


Instruction: What is statin use in rheumatoid arthritis in relation to?

Output: actual cardiovascular risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is statin use in rheumatoid arthritis in relation to?. ### Response: actual cardiovascular risk.


Instruction: What is evidence for substantial undertreatment of lipid-associated cardiovascular risk?

Output: protease inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is evidence for substantial undertreatment of lipid-associated cardiovascular risk?. ### Response: protease inhibitors.


Instruction: When did Friis-Moller N, Sabin CA, Weber R, et al. combine antiretro-viral therapy and the risk of myocardial infarction?

Output: 2003;349:1993–2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Friis-Moller N, Sabin CA, Weber R, et al. combine antiretro-viral therapy and the risk of myocardial infarction?. ### Response: 2003;349:1993–2003.


Instruction: What is the risk of myocardial infarction?

Output: Assessing and refin-ing myocardial infarction risk estimation among patients with human immunodeficiency virus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of myocardial infarction?. ### Response: Assessing and refin-ing myocardial infarction risk estimation among patients with human immunodeficiency virus.


Instruction: What was the study done by the Centers for AIDS Research Network of Integrated Clinical Systems?

Output: Assessing and refin-ing myocardial infarction risk estimation among patients with human immunodeficiency virus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the study done by the Centers for AIDS Research Network of Integrated Clinical Systems?. ### Response: Assessing and refin-ing myocardial infarction risk estimation among patients with human immunodeficiency virus.


Instruction: How many current risk algorithms are used in predicting cardiovascular events in patients with early rheumatoid arthritis?

Output: four

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many current risk algorithms are used in predicting cardiovascular events in patients with early rheumatoid arthritis?. ### Response: four.


Instruction: What is the name of the journal in which the Network of Integrated Clinical Systems was published?

Output: JAMA Cardiol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal in which the Network of Integrated Clinical Systems was published?. ### Response: JAMA Cardiol.


Instruction: How are hyperlipidemia and insu-lin resistance induced by protease inhibitors?

Output: independent of changes in body composition in patients with HIV infection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are hyperlipidemia and insu-lin resistance induced by protease inhibitors?. ### Response: independent of changes in body composition in patients with HIV infection.


Instruction: What is independent of changes in body composition in patients with HIV infection?

Output: Hyperlipidemia and insu-lin resistance are induced by protease inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is independent of changes in body composition in patients with HIV infection?. ### Response: Hyperlipidemia and insu-lin resistance are induced by protease inhibitors.


Instruction: When did J Acquir Immune Defic Syndr. 2000;23:35–43?

Output: 2000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J Acquir Immune Defic Syndr. 2000;23:35–43?. ### Response: 2000.


Instruction: What is the name of the Swiss HIV Cohort Study?

Output: Ledergerber B, Furrer H, Rickenbach M, et al. Factors associated with the incidence of type 2 diabetes mellitus in HIV-infected par -ticipants in the Swiss HIV Cohort Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Swiss HIV Cohort Study?. ### Response: Ledergerber B, Furrer H, Rickenbach M, et al. Factors associated with the incidence of type 2 diabetes mellitus in HIV-infected par -ticipants in the Swiss HIV Cohort Study.


Instruction: How many people were infected with type 2 diabetes mellitus in 2007?

Output: 111

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were infected with type 2 diabetes mellitus in 2007?. ### Response: 111.


Instruction: What is rheumatoid arthritis a population-based cohort study?

Output: Glucocorticoids and cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is rheumatoid arthritis a population-based cohort study?. ### Response: Glucocorticoids and cardiovascular events.


Instruction: What is the impact of serum lipid measures and systemic inflammation on the risk of cardiovascular disease?

Output: umatoid arthritis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact of serum lipid measures and systemic inflammation on the risk of cardiovascular disease?. ### Response: umatoid arthritis.


Instruction: What is rheumatoid arthritis known for?

Output: the impact of serum lipid measures and systemic inflammation on the risk of cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is rheumatoid arthritis known for?. ### Response: the impact of serum lipid measures and systemic inflammation on the risk of cardiovascular disease.


Instruction: What is the name of the disease that is associated with lupus erythema-tosus?

Output: rheumatoid arthritis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease that is associated with lupus erythema-tosus?. ### Response: rheumatoid arthritis.


Instruction: In what year was the journal Ann Rheum Dis. published?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was the journal Ann Rheum Dis. published?. ### Response: 2015.


Instruction: What is VOYAGER an indiVidual patient data meta-analysis of?

Output: statin therapY

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is VOYAGER an indiVidual patient data meta-analysis of?. ### Response: statin therapY.


Instruction: What is the extended release of XL?

Output: VOYAGER

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the extended release of XL?. ### Response: VOYAGER.


Instruction: When was the download from ahajournals.org?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the download from ahajournals.org?. ### Response: April 28, 2023.


Instruction: What is another term for cancer-associated thrombosis?

Output: cancer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for cancer-associated thrombosis?. ### Response: cancer.


Instruction: How long does extended anticoagulant therapy last?

Output: 3 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does extended anticoagulant therapy last?. ### Response: 3 months.


Instruction: What is the grade 1B of therapy?

Output: 3 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the grade 1B of therapy?. ### Response: 3 months.


Instruction: What is the Grade 2B of anticoagulant therapy?

Output: recurrent VTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Grade 2B of anticoagulant therapy?. ### Response: recurrent VTE.


Instruction: What should be reassessed at periodic intervals?

Output: continuing use of treatments

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be reassessed at periodic intervals?. ### Response: continuing use of treatments.


Instruction: Aspirin is expected to be much lesseffective at preventing recurrent VTE than what?

Output: anticoagulants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Aspirin is expected to be much lesseffective at preventing recurrent VTE than what?. ### Response: anticoagulants.


Instruction: What do PE who are stopping anticoagulant therapy not have a contraindication to?

Output: aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do PE who are stopping anticoagulant therapy not have a contraindication to?. ### Response: aspirin.


Instruction: What is a reasonablealternative to anticoagulant therapy in patients whowant extended therapy?

Output: serial imaging of thedeep veins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a reasonablealternative to anticoagulant therapy in patients whowant extended therapy?. ### Response: serial imaging of thedeep veins.


Instruction: What is one of the benefits of aspirin that needs to bebalanced against the risk of bleeding andinconvenience?

Output: VTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the benefits of aspirin that needs to bebalanced against the risk of bleeding andinconvenience?. ### Response: VTE.


Instruction: What should be reevaluated when patients stop anticoagulant therapy?

Output: Use of aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be reevaluated when patients stop anticoagulant therapy?. ### Response: Use of aspirin.


Instruction: What is a common cause of isolated distal DVT of the leg?

Output: forextension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a common cause of isolated distal DVT of the leg?. ### Response: forextension.


Instruction: What type of imaging is recommended for 2 weeks over anticoagulation (Grade 2C)or (ii) with severe symptoms or risk factors forjournal.publications.chestnet.org 317

Output: serial imaging of thedeep veins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of imaging is recommended for 2 weeks over anticoagulation (Grade 2C)or (ii) with severe symptoms or risk factors forjournal.publications.chestnet.org 317. ### Response: serial imaging of thedeep veins.


Instruction: What is the name of the group that attempts to develop recommendations for BP reduction and the man-agement of CAD in its various manifestations?

Output: Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that attempts to develop recommendations for BP reduction and the man-agement of CAD in its various manifestations?. ### Response: Hypertension.


Instruction: What does the writing group propose when data are meager or lacking?

Output: consensus recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the writing group propose when data are meager or lacking?. ### Response: consensus recommendations.


Instruction: What has the writing committee not addressed in the pediatric age group?

Output: hypertension or IHD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has the writing committee not addressed in the pediatric age group?. ### Response: hypertension or IHD.


Instruction: The writing group has proposed what?

Output: consensus recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The writing group has proposed what?. ### Response: consensus recommendations.


Instruction: In what age group does IHD occur?

Output: pediatric

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what age group does IHD occur?. ### Response: pediatric.


Instruction: In what year was 24-hour ambulatory BP monitoring the subject of a scientific statement?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was 24-hour ambulatory BP monitoring the subject of a scientific statement?. ### Response: 2005.


Instruction: What has been developed according to the AHA format shown in the document?

Output: Recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been developed according to the AHA format shown in the document?. ### Response: Recommendations.


Instruction: What format is shown in Table 1?

Output: AHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What format is shown in Table 1?. ### Response: AHA.


Instruction: The general design of the scientific statement is based on the concept that each of the clinical sections refers to a particular subset of patients?

Output: so each section should pro-vide a stand-alone description of the recommendations and their justification independently of the other sections

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The general design of the scientific statement is based on the concept that each of the clinical sections refers to a particular subset of patients?. ### Response: so each section should pro-vide a stand-alone description of the recommendations and their justification independently of the other sections.


Instruction: What should make it easier for practitioners to extract the information relevant to any particular patient without needing to cross-reference?

Output: each section should pro-vide a stand-alone description of the recommendations and their justification independently of the other sections

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should make it easier for practitioners to extract the information relevant to any particular patient without needing to cross-reference?. ### Response: each section should pro-vide a stand-alone description of the recommendations and their justification independently of the other sections.


Instruction: What should the stand-alone description of recommendations and their justification do?

Output: independently of the other sections

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should the stand-alone description of recommendations and their justification do?. ### Response: independently of the other sections.


Instruction: What will increase the utility of this document?

Output: extract the infor -mation relevant to any particular patient without needing to cross-reference

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will increase the utility of this document?. ### Response: extract the infor -mation relevant to any particular patient without needing to cross-reference.


Instruction: What may be repeated from one section to the next?

Output: information

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be repeated from one section to the next?. ### Response: information.


Instruction: What is a major independent risk factor for CAD for all age/race/sex groups?

Output: Epidemiology of Hypertension and CADHypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a major independent risk factor for CAD for all age/race/sex groups?. ### Response: Epidemiology of Hypertension and CADHypertension.


Instruction: What does the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure use?

Output: traditional definition of hypertension as an SBP of ≥140 mm Hg or a DBP of ≥90 mm Hg and/or the current use of antihyperten-sive medication

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure use?. ### Response: traditional definition of hypertension as an SBP of ≥140 mm Hg or a DBP of ≥90 mm Hg and/or the current use of antihyperten-sive medication.


Instruction: What is the traditional definition of hypertension?

Output: SBP of ≥140 mm Hg or a DBP of ≥90 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the traditional definition of hypertension?. ### Response: SBP of ≥140 mm Hg or a DBP of ≥90 mm Hg.


Instruction: How many adults are estimated to be using this definition?

Output: 65 million

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many adults are estimated to be using this definition?. ### Response: 65 million.


Instruction: What percentage of the adult population is hypertension defined as?

Output: one fourth

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the adult population is hypertension defined as?. ### Response: one fourth.


Instruction: How many adult Americans have hypertension?

Output: 65 million

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many adult Americans have hypertension?. ### Response: 65 million.


Instruction: How much of the adult population of the United States has hypertension?"

Output: one fourth

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the adult population of the United States has hypertension?". ### Response: one fourth.


Instruction: What is the SBP of a quarter of the population?

Output: 120 to 139 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the SBP of a quarter of the population?. ### Response: 120 to 139 mm Hg.


Instruction: What does the DBP of 80 to 89 mm Hg mean?

Output: prehypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the DBP of 80 to 89 mm Hg mean?. ### Response: prehypertension.


Instruction: How does the form of BP elevation differ as a function of age?

Output: DBP elevation predominating in young hypertensive indi-vidual

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does the form of BP elevation differ as a function of age?. ### Response: DBP elevation predominating in young hypertensive indi-vidual.


Instruction: In young hypertensive indi-viduals, what does DBP elevation predominate?

Output: BP elevation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In young hypertensive indi-viduals, what does DBP elevation predominate?. ### Response: BP elevation.


Instruction: What is isolated systolic hypertension?

Output: systolic hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is isolated systolic hypertension?. ### Response: systolic hypertension.


Instruction: How is the prevalence of hypertension directly proportional to the age of the population?

Output: directly proportional to the age of the population, with more than half of Americans >65 years of age having a high BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the prevalence of hypertension directly proportional to the age of the population?. ### Response: directly proportional to the age of the population, with more than half of Americans >65 years of age having a high BP.


Instruction: What percentage of Americans over 65 have a high BP?

Output: more than half

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of Americans over 65 have a high BP?. ### Response: more than half.


Instruction: What study has estimated the remaining lifetime risk of developing hypertension at 90% for men and women?

Output: Framingham Heart Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What study has estimated the remaining lifetime risk of developing hypertension at 90% for men and women?. ### Response: Framingham Heart Study.


Instruction: What are women not yet hypertensive by middle age?

Output: The Framingham Heart Study has esti-mated the remaining lifetime risk of developing hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are women not yet hypertensive by middle age?. ### Response: The Framingham Heart Study has esti-mated the remaining lifetime risk of developing hypertension.


Instruction: What is a change with age in the relative?

Output: BP elevation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a change with age in the relative?. ### Response: BP elevation.


Instruction: What was the name of the trial that randomized 10,732 patients with STEMI toaspiration thrombectomy before primary PCI or primaryPCI only?

Output: The TOTAL (Trial of R outine Aspiration Throm-bectomy With PCI Versus PCI Alone in Patients WithSTEMI)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the trial that randomized 10,732 patients with STEMI toaspiration thrombectomy before primary PCI or primaryPCI only?. ### Response: The TOTAL (Trial of R outine Aspiration Throm-bectomy With PCI Versus PCI Alone in Patients WithSTEMI).


Instruction: What was performed in 7.1%of the primary PC I –only group?

Output: Bailout thrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was performed in 7.1%of the primary PC I –only group?. ### Response: Bailout thrombectomy.


Instruction: How many patients were randomized to the TOTAL trial?

Output: 10,732

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were randomized to the TOTAL trial?. ### Response: 10,732.


Instruction: What was the rate of cross-over from aspiration thrombectomy before primary PCI toprimary PCI only?

Output: 4.6%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the rate of cross-over from aspiration thrombectomy before primary PCI toprimary PCI only?. ### Response: 4.6%..


Instruction: What is the primary endpoint of cardiova scular death, recurrent MI,cardiogenic shock, or New York Heart Association class IVheart failure at 180 days?

Output: stent thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary endpoint of cardiova scular death, recurrent MI,cardiogenic shock, or New York Heart Association class IVheart failure at 180 days?. ### Response: stent thrombosis.


Instruction: How long did New York Heart Association class IVheart failure last?

Output: 180 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did New York Heart Association class IVheart failure last?. ### Response: 180 days.


Instruction: What was the primary endpoint of the study?

Output: stent thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary endpoint of the study?. ### Response: stent thrombosis.


Instruction: How many trials were included in an updated meta-analysis?

Output: 17

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many trials were included in an updated meta-analysis?. ### Response: 17.


Instruction: What was found to be no signi ficant reduction in death, reinfarction, orstent thrombosis?

Output: routine aspiration thrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was found to be no signi ficant reduction in death, reinfarction, orstent thrombosis?. ### Response: routine aspiration thrombectomy.


Instruction: What is a signi ficant reduction in death, reinfarction, orstent thrombosis with routine aspiration thrombectomy?

Output: major adverse cardiac events, stent thrombosis, and death(38–42). However, subgroup analyses from the TASTE andTOTAL trials did not suggest relative bene ﬁtf r o ma s p i r a -tion thrombectomy before primary PCI in patients withhigher thrombus burden or in pa tients with initial Throm-bolysis in Myocardial Infarction (TIMI) ﬂow grade 0 –1o rl e f tanterior descending artery/anterior infarction (34,35) .O nt h eb a s i so ft h er e s u l t so ft h e s es t u d i e s ,t h ep r i o rClass IIa recommendation for aspiration thrombectomyhas been changed. Routine aspiration thrombectomybefore primary PCI is now not recommended

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a signi ficant reduction in death, reinfarction, orstent thrombosis with routine aspiration thrombectomy?. ### Response: major adverse cardiac events, stent thrombosis, and death(38–42). However, subgroup analyses from the TASTE andTOTAL trials did not suggest relative bene ﬁtf r o ma s p i r a -tion thrombectomy before primary PCI in patients withhigher thrombus burden or in pa tients with initial Throm-bolysis in Myocardial Infarction (TIMI) ﬂow grade 0 –1o rl e f tanterior descending artery/anterior infarction (34,35) .O nt h eb a s i so ft h er e s u l t so ft h e s es t u d i e s ,t h ep r i o rClass IIa recommendation for aspiration thrombectomyhas been changed. Routine aspiration thrombectomybefore primary PCI is now not recommended.


Instruction: What has m a l lb u t increased in the risk of stroke?

Output: Aspiration thrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has m a l lb u t increased in the risk of stroke?. ### Response: Aspiration thrombectomy.


Instruction: How many previous studies have found that higherthrombus burden in patients?

Output: 35

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many previous studies have found that higherthrombus burden in patients?. ### Response: 35.


Instruction: How many previous studies have found that higherthrombus burden in patients with STEMI is independentlyassociated with higher risks of distal embolization?

Output: Several

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many previous studies have found that higherthrombus burden in patients with STEMI is independentlyassociated with higher risks of distal embolization?. ### Response: Several.


Instruction: What did subgroup analyses from the TASTE and TOTAL trials not suggest?

Output: relative bene

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did subgroup analyses from the TASTE and TOTAL trials not suggest?. ### Response: relative bene.


Instruction: What did not suggest relative bene fitf r o ma s p i ra tion thrombectomy before primary PCI?

Output: subgroup analyses from the TASTE andTOTAL trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did not suggest relative bene fitf r o ma s p i ra tion thrombectomy before primary PCI?. ### Response: subgroup analyses from the TASTE andTOTAL trials.


Instruction: What did trials not suggest in patients with higher thrombi burden or in pa tients with initial Throm-bolysis in Myocardial Infarction?

Output: relative bene ﬁtf r o ma s p i r a -tion thrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did trials not suggest in patients with higher thrombi burden or in pa tients with initial Throm-bolysis in Myocardial Infarction?. ### Response: relative bene ﬁtf r o ma s p i r a -tion thrombectomy.


Instruction: What is a class IIa recommendation for aspiration thrombectomy?

Output: Class IIb

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a class IIa recommendation for aspiration thrombectomy?. ### Response: Class IIb.


Instruction: What has been changed?

Output: Class IIa recommendation for aspiration thrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been changed?. ### Response: Class IIa recommendation for aspiration thrombectomy.


Instruction: What is no longer recommended before primary PCI?

Output: Routine aspiration thrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is no longer recommended before primary PCI?. ### Response: Routine aspiration thrombectomy.


Instruction: Forpatients undergoingprimary PCI (29-32), what is not well established?

Output: The usefulness ofselective andbailout aspirationthrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Forpatients undergoingprimary PCI (29-32), what is not well established?. ### Response: The usefulness ofselective andbailout aspirationthrombectomy.


Instruction: What does PCI indicate?

Output: percutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does PCI indicate?. ### Response: percutaneous coronary intervention.


Instruction: How is Routine aspirationthrombectomy before PCI?

Output: notuseful

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is Routine aspirationthrombectomy before PCI?. ### Response: notuseful.


Instruction: What is a new recommendation added forroutine aspirationthrombectomybefore PCI?

Output: “Class III: NoBeneﬁt

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a new recommendation added forroutine aspirationthrombectomybefore PCI?. ### Response: “Class III: NoBeneﬁt.


Instruction: What indicates percutaneous coronary intervention?

Output: PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates percutaneous coronary intervention?. ### Response: PCI.


Instruction: What type of therapy is recommended only in very specific patients?

Output: antiplatelet therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is recommended only in very specific patients?. ### Response: antiplatelet therapy.


Instruction: What is recommended in patients with early arriv-ing minor stroke?

Output: Guideline for the Secondary Prevention of Ischemic Strokeantiplatelet therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended in patients with early arriv-ing minor stroke?. ### Response: Guideline for the Secondary Prevention of Ischemic Strokeantiplatelet therapy.


Instruction: Atrial fibrillation remains a common and high-risk condition for what?

Output: second ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atrial fibrillation remains a common and high-risk condition for what?. ### Response: second ischemic stroke.


Instruction: What is usually recommended if the patient has no contraindications?

Output: Anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is usually recommended if the patient has no contraindications?. ### Response: Anticoagulation.


Instruction: Heart rhythm monitoring is usu-ally recommended for what if no other cause of stroke is discovered?

Output: occult atrial fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Heart rhythm monitoring is usu-ally recommended for what if no other cause of stroke is discovered?. ### Response: occult atrial fibrillation.


Instruction: What is an important and treatable cause of stroke?

Output: Extracranial carotid artery disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an important and treatable cause of stroke?. ### Response: Extracranial carotid artery disease.


Instruction: What should patients with severe stenosis have fixed?

Output: Patients with severe stenosis ipsilateral to a nondisabling stroke or transient ischemic attack who are candidates for intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients with severe stenosis have fixed?. ### Response: Patients with severe stenosis ipsilateral to a nondisabling stroke or transient ischemic attack who are candidates for intervention.


Instruction: When should the stenosis be fixed?

Output: relatively early after their ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When should the stenosis be fixed?. ### Response: relatively early after their ischemic stroke.


Instruction: What should be driven by specific patient comor-bidities and features of their vascular anatomy?

Output: The choice between carotid endarterectomy and carotid artery stenting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be driven by specific patient comor-bidities and features of their vascular anatomy?. ### Response: The choice between carotid endarterectomy and carotid artery stenting.


Instruction: Patients with severe intracranial stenosis in the vascular territory of ischemic stroke or transient ischemia should have what fixated?

Output: stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with severe intracranial stenosis in the vascular territory of ischemic stroke or transient ischemia should have what fixated?. ### Response: stenosis.


Instruction: Who should not receive angioplasty and stenting as a first-line therapy for preventing recur-ence?

Output: Patients with severe intracranial stenosis in the vascular territory of ischemic stroke or transient ischemic attack

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should not receive angioplasty and stenting as a first-line therapy for preventing recur-ence?. ### Response: Patients with severe intracranial stenosis in the vascular territory of ischemic stroke or transient ischemic attack.


Instruction: Aggressive medical management of risk factors and short-term dual antiplatelet therapy are preferred?

Output: 9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Aggressive medical management of risk factors and short-term dual antiplatelet therapy are preferred?. ### Response: 9.


Instruction: There have been several studies evaluating what type of stroke prevention?

Output: sec-ondary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There have been several studies evaluating what type of stroke prevention?. ### Response: sec-ondary.


Instruction: How many studies have evaluated sec-ondary stroke prevention of patent foramen ovale closure since the previous guideline in 2014?

Output: several

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies have evaluated sec-ondary stroke prevention of patent foramen ovale closure since the previous guideline in 2014?. ### Response: several.


Instruction: What age group are patients who meet each criteria?

Output: 18–60 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What age group are patients who meet each criteria?. ### Response: 18–60 years.


Instruction: What is a nonlacunar stroke?

Output: no other identified cause

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a nonlacunar stroke?. ### Response: no other identified cause.


Instruction: What are high risk patent foramen ovale features?

Output: age 18–60 years, nonlacunar stroke, no other identified cause

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are high risk patent foramen ovale features?. ### Response: age 18–60 years, nonlacunar stroke, no other identified cause.


Instruction: Patients with embolic stroke of uncertain source should not be treated empirically with what?

Output: anticoagu-lants or ticagrelor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with embolic stroke of uncertain source should not be treated empirically with what?. ### Response: anticoagu-lants or ticagrelor.


Instruction: What do the AHA/ASA translate into clinical practice guidelines with rec-ommendations?

Output: sci-entific evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do the AHA/ASA translate into clinical practice guidelines with rec-ommendations?. ### Response: sci-entific evidence.


Instruction: What do these guidelines provide a foundation for?

Output: the delivery of quality cerebrovascular care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do these guidelines provide a foundation for?. ### Response: the delivery of quality cerebrovascular care.


Instruction: Who sponsor the development and implementation of these guidelines?

Output: American Heart Association (AHA)/American Stroke Association (ASA)*

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who sponsor the development and implementation of these guidelines?. ### Response: American Heart Association (AHA)/American Stroke Association (ASA)*.


Instruction: Who sponsors the development and publication of clinical practice guidelines without commercial support?

Output: AHA/ASA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who sponsors the development and publication of clinical practice guidelines without commercial support?. ### Response: AHA/ASA.


Instruction: Who volunteer their time to the writing and review efforts?

Output: mem-bers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who volunteer their time to the writing and review efforts?. ### Response: mem-bers.


Instruction: What provide recommendations applicable to patients with or at risk of developing cerebrovascular disease?

Output: Clinical practice guidelines for stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What provide recommendations applicable to patients with or at risk of developing cerebrovascular disease?. ### Response: Clinical practice guidelines for stroke.


Instruction: What are patients at risk of developing?

Output: cerebrovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients at risk of developing?. ### Response: cerebrovascular disease.


Instruction: What is the focus of the study?

Output: medical practice in the United States

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the focus of the study?. ### Response: medical practice in the United States.


Instruction: Where are many aspects relevant to patients?

Output: throughout the world

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are many aspects relevant to patients?. ### Response: throughout the world.


Instruction: What is the best hydrationregimen to prevent contrast media-induced nephrotoxicity?

Output: N-acetylcysteine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the best hydrationregimen to prevent contrast media-induced nephrotoxicity?. ### Response: N-acetylcysteine.


Instruction: What did Mueller C, Buerkle G, Buettner HJ, et al. do to prevent contrast media-associated nephropathy?

Output: randomized comparison of 2 hydrationregimens

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Mueller C, Buerkle G, Buettner HJ, et al. do to prevent contrast media-associated nephropathy?. ### Response: randomized comparison of 2 hydrationregimens.


Instruction: How many patients underwent coronary angioplasty?

Output: 1620

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients underwent coronary angioplasty?. ### Response: 1620.


Instruction: What did Solomon R, Werner C, and Mann D use to prevent acute decreases?

Output: saline, mannitol, andfurosemide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Solomon R, Werner C, and Mann D use to prevent acute decreases?. ### Response: saline, mannitol, andfurosemide.


Instruction: What does saline, mannitol, and furosemide prevent?

Output: acute decreases in renal function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does saline, mannitol, and furosemide prevent?. ### Response: acute decreases in renal function.


Instruction: What does N Engl J Med. 1994:331:1416–20.275?

Output: Effects of saline, mannitol, andfurosemide to prevent acute decreases in renal function induced byradiocontrast agents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does N Engl J Med. 1994:331:1416–20.275?. ### Response: Effects of saline, mannitol, andfurosemide to prevent acute decreases in renal function induced byradiocontrast agents.


Instruction: How did Trivedi, Moore, Nasr, and others assess the role of hydration on contrastnephrotoxicity?

Output: randomized prospective trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Trivedi, Moore, Nasr, and others assess the role of hydration on contrastnephrotoxicity?. ### Response: randomized prospective trial.


Instruction: What causes contrastnephrotoxicity?

Output: saline hydration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes contrastnephrotoxicity?. ### Response: saline hydration.


Instruction: What is the name of the study that investigated contrast volume during percutaneous coronary intervention and subsequent contrast-induced nephropathies and mortality?

Output: LIPSIA-N-ACC (Prospective, Single-Blind,Placebo-Controlled, Randomized Leipzig Immediate PercutaneouSCoronary Intervention Acute Myocardial Infarction N-ACC) trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated contrast volume during percutaneous coronary intervention and subsequent contrast-induced nephropathies and mortality?. ### Response: LIPSIA-N-ACC (Prospective, Single-Blind,Placebo-Controlled, Randomized Leipzig Immediate PercutaneouSCoronary Intervention Acute Myocardial Infarction N-ACC) trial.


Instruction: What is the incidence and risk factors of acute renal failure aftercoronary intervention?

Output: relationship to mor-tality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the incidence and risk factors of acute renal failure aftercoronary intervention?. ### Response: relationship to mor-tality.


Instruction: What are the effects of contrastmedia on renal hemodynamics and tubular function in chronic renal failure?

Output: Early effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the effects of contrastmedia on renal hemodynamics and tubular function in chronic renal failure?. ### Response: Early effects.


Instruction: What is N-acetylcysteine used for in contrast-induced nephrotoxicity?

Output: unsupervised clus-tering to resolve heterogeneity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is N-acetylcysteine used for in contrast-induced nephrotoxicity?. ### Response: unsupervised clus-tering to resolve heterogeneity.