Instruction: What group had very low certainty?

Output: intervention group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What group had very low certainty?. ### Response: intervention group.


Instruction: What is more expensive than overlapping DOAC therapy?

Output: LMWH-bridgingtherapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more expensive than overlapping DOAC therapy?. ### Response: LMWH-bridgingtherapy.


Instruction: Atrial fibrillation: diagnosis and manag emen t NICE guideline Published: 27 April 2021 www.nice.or g.uk/guidance/ng196

Output: Atrial fi brilla tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atrial fibrillation: diagnosis and manag emen t NICE guideline Published: 27 April 2021 www.nice.or g.uk/guidance/ng196. ### Response: Atrial fi brilla tion.


Instruction: What is a risk factor for sudden cardiac death in adults late in life?

Output: Left ventricular longitudinal function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for sudden cardiac death in adults late in life?. ### Response: Left ventricular longitudinal function.


Instruction: What is left ventricular dysfunction?

Output: a risk factor for sudden cardiac death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is left ventricular dysfunction?. ### Response: a risk factor for sudden cardiac death.


Instruction: When did N Engl J Med. 1993;329:593-9?

Output: 1993

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did N Engl J Med. 1993;329:593-9?. ### Response: 1993.


Instruction: What is a risk factor for sudden cardiac death in adults late after repair of tetralogy of Fallot?

Output: Left ventricular dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for sudden cardiac death in adults late after repair of tetralogy of Fallot?. ### Response: Left ventricular dysfunction.


Instruction: When did J Am Coll Cardiol. 2002;40:1675-80?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J Am Coll Cardiol. 2002;40:1675-80?. ### Response: 2002.


Instruction: What was a randomized trial of pulmo-nary valve replacement with and without right ventricular remodel-ing surgery?

Output: Circulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a randomized trial of pulmo-nary valve replacement with and without right ventricular remodel-ing surgery?. ### Response: Circulation.


Instruction: What is ventricular remodel-ing surgery called?

Output: beta-blockade

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ventricular remodel-ing surgery called?. ### Response: beta-blockade.


Instruction: What is the name of the multicentre study that examined risk factors for ar -rhythmia and sudden cardiac death late after repair of tetralogy of Fallot?

Output: Lancet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multicentre study that examined risk factors for ar -rhythmia and sudden cardiac death late after repair of tetralogy of Fallot?. ### Response: Lancet.


Instruction: In what year was the Lancet published in 356:975–81?

Output: 2000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was the Lancet published in 356:975–81?. ### Response: 2000.


Instruction: What is the difference between intervention and nonintervention in pulmonary valve replacement?

Output: Optimal timing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between intervention and nonintervention in pulmonary valve replacement?. ### Response: Optimal timing.


Instruction: What are the differences in surgical referral patterns in adults with tetralogy of Fallot with pulmonary regurgitation?

Output: Variability

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the differences in surgical referral patterns in adults with tetralogy of Fallot with pulmonary regurgitation?. ### Response: Variability.


Instruction: What is the best timing for pulmo-nary valve replacement in adults after tetralogy of Fallot repair?

Output: Twenty-to-thirty-seven-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the best timing for pulmo-nary valve replacement in adults after tetralogy of Fallot repair?. ### Response: Twenty-to-thirty-seven-year.


Instruction: What predicts sustained tachyarrhythmia in repaired tetralogy of Fallot?

Output: Right atrial area and right ventricular outflow tract akinetic length

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What predicts sustained tachyarrhythmia in repaired tetralogy of Fallot?. ### Response: Right atrial area and right ventricular outflow tract akinetic length.


Instruction: When did Bonello B, Kempny A, Uebing A, et al. perform a twenty-to-thirty-seven-year follow-up after repair?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Bonello B, Kempny A, Uebing A, et al. perform a twenty-to-thirty-seven-year follow-up after repair?. ### Response: 1999.


Instruction: How long after a fallot repair did Nrgaard MA, Lauridsen P, Helvind M follow up?

Output: Twenty-to-thirty-seven-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after a fallot repair did Nrgaard MA, Lauridsen P, Helvind M follow up?. ### Response: Twenty-to-thirty-seven-year.


Instruction: How many years follow-up after repair for tetralogy of Fallot?

Output: Twenty-to-thirty-seven

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many years follow-up after repair for tetralogy of Fallot?. ### Response: Twenty-to-thirty-seven.


Instruction: What year did Eur J Cardiothorac Surg.16:125-30?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Eur J Cardiothorac Surg.16:125-30?. ### Response: 1999.


Instruction: Silka MJ, Hardy BG, Menashe VD, et al. A population-based prospective evaluation of risk of sudden cardiac death after operation for com-mon congenital heart defects.

Output: Silka MJ, Hardy BG, Menashe VD, et al. A population-based prospec-tive evaluation of risk of sudden cardiac death after operation for com-mon congenital heart defects. J Am Coll Cardiol. 1998;32:245–51

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Silka MJ, Hardy BG, Menashe VD, et al. A population-based prospective evaluation of risk of sudden cardiac death after operation for com-mon congenital heart defects.. ### Response: Silka MJ, Hardy BG, Menashe VD, et al. A population-based prospec-tive evaluation of risk of sudden cardiac death after operation for com-mon congenital heart defects. J Am Coll Cardiol. 1998;32:245–51.


Instruction: What is the name of the study that evaluated beta-blockade in patients with heart defects?

Output: Norozi K, Bahlmann J, Raab B, et al. A prospective, randomized, double-blind, placebo controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated beta-blockade in patients with heart defects?. ### Response: Norozi K, Bahlmann J, Raab B, et al. A prospective, randomized, double-blind, placebo controlled trial.


Instruction: When did J Am Coll Cardiol. 1998 issue 32:245–51?

Output: 1998

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J Am Coll Cardiol. 1998 issue 32:245–51?. ### Response: 1998.


Instruction: What is another name for heart defect?

Output: Left ventricular dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for heart defect?. ### Response: Left ventricular dysfunction.


Instruction: How many patients underwent surgical correction of Fallot?

Output: Twenty-to-thirty-seven

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients underwent surgical correction of Fallot?. ### Response: Twenty-to-thirty-seven.


Instruction: What predicts life-threatening ventricular arrhythmia and death in adults with repaired tetralogy of Fallot?

Output: Left ventricular longitudinal function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What predicts life-threatening ventricular arrhythmia and death in adults with repaired tetralogy of Fallot?. ### Response: Left ventricular longitudinal function.


Instruction: When did Circulation. 2012:125:2440–6. S4.3.5-33. What predict ventricular arhythmiias and death?

Output: Left ventricular longitudinal function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circulation. 2012:125:2440–6. S4.3.5-33. What predict ventricular arhythmiias and death?. ### Response: Left ventricular longitudinal function.


Instruction: How do lesion-specific dif-ferences for implantable cardioverter defibrillator therapies affect adults with congenital heart?

Output: Variability in surgical referral patterns

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do lesion-specific dif-ferences for implantable cardioverter defibrillator therapies affect adults with congenital heart?. ### Response: Variability in surgical referral patterns.


Instruction: What type of defibrillator therapies can be used in adults with congenital heart disease?

Output: implantable cardioverter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of defibrillator therapies can be used in adults with congenital heart disease?. ### Response: implantable cardioverter.


Instruction: What is the pacing Clin Electrophysiol. 2014;37:1492-8?

Output: Lesion-specific dif-ferences for implantable cardioverter defibrillator therapies in adults with congenital heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the pacing Clin Electrophysiol. 2014;37:1492-8?. ### Response: Lesion-specific dif-ferences for implantable cardioverter defibrillator therapies in adults with congenital heart disease.


Instruction: Whose working groups recommend car-diovascular magnetic resonance?

Output: European Society of Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Whose working groups recommend car-diovascular magnetic resonance?. ### Response: European Society of Cardiology.


Instruction: What are the groups of the European Society of Cardiology?

Output: working groups

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the groups of the European Society of Cardiology?. ### Response: working groups.


Instruction: What is the name of the journal that published in 2010?

Output: Circulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that published in 2010?. ### Response: Circulation.


Instruction: What is the VA/DoD Clinical Practice Guideline for the Diagnosis and Management of Hypertension in the Primary Care Setting March 2020 Page 36 of 134 benefit for the more intensive approach?

Output: Benefits of intensive therapy seem to outweigh harms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for the Diagnosis and Management of Hypertension in the Primary Care Setting March 2020 Page 36 of 134 benefit for the more intensive approach?. ### Response: Benefits of intensive therapy seem to outweigh harms.


Instruction: What did Weiss et al. look at studies targeting?

Output: a lower threshold

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Weiss et al. look at studies targeting?. ### Response: a lower threshold.


Instruction: What did Reboussin et al. (2018) find?

Output: significant reductions in the risk of major cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Reboussin et al. (2018) find?. ### Response: significant reductions in the risk of major cardiovascular events.


Instruction: What was the largest individual study to date examining cardiovascular risk?

Output: SPRINT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the largest individual study to date examining cardiovascular risk?. ### Response: SPRINT.


Instruction: What is the name of the largest individual study to date examining SBP targets?

Output: Systolic Blood Pressure Intervention Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the largest individual study to date examining SBP targets?. ### Response: Systolic Blood Pressure Intervention Trial.


Instruction: What did the SPRINT study demonstrate a 25% reduction in in the intensive treatment group?

Output: cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the SPRINT study demonstrate a 25% reduction in in the intensive treatment group?. ### Response: cardiovascular events.


Instruction: How many mm Hg was the SBP target?

Output: 120

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mm Hg was the SBP target?. ### Response: 120.


Instruction: What did Saiz et al. (2018) find benefits for reducing SBP below?

Output: 150 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Saiz et al. (2018) find benefits for reducing SBP below?. ### Response: 150 mm Hg.


Instruction: What was the SBP target?

Output: <150 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the SBP target?. ### Response: <150 mm Hg.


Instruction: How many participants were included in the SR?

Output: Only a small proportion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many participants were included in the SR?. ### Response: Only a small proportion.


Instruction: Who found no benefits for reducing SBP below 150 mm Hg?

Output: Saiz et al.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who found no benefits for reducing SBP below 150 mm Hg?. ### Response: Saiz et al..


Instruction: What is also supported by evidence for treating to a lower SBP goal for older adults?

Output: Treating to a lower SBP goal of <130 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is also supported by evidence for treating to a lower SBP goal for older adults?. ### Response: Treating to a lower SBP goal of <130 mm Hg.


Instruction: What is weaker than the evidence for treating to a SBP goal of 150 mm Hg in patients 60 years and older?

Output: Treating to a lower SBP goal of <130 mm Hg for older adults is also supported by evidence, but the research support this lower goal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is weaker than the evidence for treating to a SBP goal of 150 mm Hg in patients 60 years and older?. ### Response: Treating to a lower SBP goal of <130 mm Hg for older adults is also supported by evidence, but the research support this lower goal.


Instruction: What is the current recommendation specific to?

Output: HTN in patients age 60 and over

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the current recommendation specific to?. ### Response: HTN in patients age 60 and over.


Instruction: How many clinical trials included older people?

Output: large number

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many clinical trials included older people?. ### Response: large number.


Instruction: What does the SR by Weiss and al. 2017 support?

Output: lowering SBP to a target of 150 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the SR by Weiss and al. 2017 support?. ### Response: lowering SBP to a target of 150 mm Hg.


Instruction: Benefits clearly outweigh what?

Output: harms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Benefits clearly outweigh what?. ### Response: harms.


Instruction: What is less consistent in the evidence supporting additional blood pressure reductions for patients with an SBP between 130 and 150 mm Hg?

Output: Benefits clearly outweigh harms and burdens associated with this therapy. There is less consistency in the evidence supporting additional blood pressure reductions for patients with an SBP between 130 and 150 mm Hg. This more intensive or aggressive appro ach often requires additional medications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is less consistent in the evidence supporting additional blood pressure reductions for patients with an SBP between 130 and 150 mm Hg?. ### Response: Benefits clearly outweigh harms and burdens associated with this therapy. There is less consistency in the evidence supporting additional blood pressure reductions for patients with an SBP between 130 and 150 mm Hg. This more intensive or aggressive appro ach often requires additional medications.


Instruction: What does more intensive or aggressive approach often require?

Output: additional medications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does more intensive or aggressive approach often require?. ### Response: additional medications.


Instruction: What do some people not prefer?

Output: medications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do some people not prefer?. ### Response: medications.


Instruction: What seem to outweigh the harms of intensive therapy?

Output: Benefits

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What seem to outweigh the harms of intensive therapy?. ### Response: Benefits.


Instruction: What may older or frail people develop side effects while titrating therapy to achieve lower blood pressures?

Output: they may wish to have medications tapered back or changed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may older or frail people develop side effects while titrating therapy to achieve lower blood pressures?. ### Response: they may wish to have medications tapered back or changed.


Instruction: What may they wish to have medications tapered back or changed?

Output: if older or particularly frail people develop side effects while titrating therapy to achieve lower blood pressures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may they wish to have medications tapered back or changed?. ### Response: if older or particularly frail people develop side effects while titrating therapy to achieve lower blood pressures.


Instruction: What did the Work Group systematically review?

Output: evidence identified in the evidence review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Work Group systematically review?. ### Response: evidence identified in the evidence review.


Instruction: What is high confidence in the quality of evidence for people with an SBP between 130 and 150mm Hg?

Output: additional reductions in blood pressure are beneficial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is high confidence in the quality of evidence for people with an SBP between 130 and 150mm Hg?. ### Response: additional reductions in blood pressure are beneficial.


Instruction: What did Ettehad et al. (2016) find about a 10 mm Hg reduction in SBP?

Output: improved cardiovascular outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Ettehad et al. (2016) find about a 10 mm Hg reduction in SBP?. ### Response: improved cardiovascular outcomes.


Instruction: What was associated with improved cardiovascular outcomes?

Output: 10 mm Hg reduction in SBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with improved cardiovascular outcomes?. ### Response: 10 mm Hg reduction in SBP.


Instruction: What did Reboussin et al. (2018) find about cardiovascular outcomes?

Output: significant reductions in the risk of major cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Reboussin et al. (2018) find about cardiovascular outcomes?. ### Response: significant reductions in the risk of major cardiovascular events.


Instruction: What is there some inconsistency in?

Output: the data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is there some inconsistency in?. ### Response: the data.


Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020?

Output: Page 22 of 127 medications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020?. ### Response: Page 22 of 127 medications.


Instruction: How many medications are there for patients who may not benefit from pharmacotherapy?

Output: 127

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many medications are there for patients who may not benefit from pharmacotherapy?. ### Response: 127.


Instruction: What is FRS?

Output: a tool used to estimate the 10 -year risk of having a CV event

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is FRS?. ### Response: a tool used to estimate the 10 -year risk of having a CV event.


Instruction: What is a tool used to estimate the 10 -year risk of having a CV event?

Output: FRS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a tool used to estimate the 10 -year risk of having a CV event?. ### Response: FRS.


Instruction: What is PCE?

Output: a central tool recommended by the American College of Cardiology/American Heart Association (ACC/AHA)  based on a 10 -year CVD risk estimation from a pooled cohort equation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PCE?. ### Response: a central tool recommended by the American College of Cardiology/American Heart Association (ACC/AHA)  based on a 10 -year CVD risk estimation from a pooled cohort equation.


Instruction: How long is the VARS -CVD risk score calculator?

Output: five -year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the VARS -CVD risk score calculator?. ### Response: five -year.


Instruction: What is the VA's EHR used for?

Output: Electronic Health Record

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA's EHR used for?. ### Response: Electronic Health Record.


Instruction: What are CVD risk calculators used for?

Output: help identify patients who may  benefit the most from treatment for primary prevention with statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are CVD risk calculators used for?. ### Response: help identify patients who may  benefit the most from treatment for primary prevention with statin therapy.


Instruction: What are the two most commonly used CVD risks calculators in clinical practice?

Output: FRS or the PCE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the two most commonly used CVD risks calculators in clinical practice?. ### Response: FRS or the PCE.


Instruction: What do providers commonly use to calculate a 10 -year CV risk estimation?

Output: FRS or the PCE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do providers commonly use to calculate a 10 -year CV risk estimation?. ### Response: FRS or the PCE.


Instruction: Evidence supports the use of the revised or updated PCE for what?

Output: CV risk estimates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Evidence supports the use of the revised or updated PCE for what?. ### Response: CV risk estimates.


Instruction: The revised PCE has higher adherence rates than the FRS or PCE?

Output: FRS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The revised PCE has higher adherence rates than the FRS or PCE?. ### Response: FRS.


Instruction: Why does the revised PCE have higher accuracy than the FRS for CV risk estimates?

Output: it considers race and history of DM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why does the revised PCE have higher accuracy than the FRS for CV risk estimates?. ### Response: it considers race and history of DM.


Instruction: What does the revision PCE take into account?

Output: race and history of DM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the revision PCE take into account?. ### Response: race and history of DM.


Instruction: How did the Work Group review this recommendation?

Output: systematically reviewed  evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did the Work Group review this recommendation?. ### Response: systematically reviewed  evidence.


Instruction: What did the Work Group systematically review related to the Amended recommendation?

Output: evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Work Group systematically review related to the Amended recommendation?. ### Response: evidence.


Instruction: Why was the Work group's confidence in the quality of the evidence low?

Output: inconsistency, imprecision, and the unknown applicability of risk calculators other than FRS and PCE in the VA/DoD setting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the Work group's confidence in the quality of the evidence low?. ### Response: inconsistency, imprecision, and the unknown applicability of risk calculators other than FRS and PCE in the VA/DoD setting.


Instruction: The Work Group's trust in the evidence was low because of inconsistency, imprecision, and what else?

Output: unknown applicability of risk calculators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The Work Group's trust in the evidence was low because of inconsistency, imprecision, and what else?. ### Response: unknown applicability of risk calculators.


Instruction: What other calculators are used in the VA/DoD setting?

Output: FRS and PCE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What other calculators are used in the VA/DoD setting?. ### Response: FRS and PCE.


Instruction: Why do the benefits of using a 10 -year risk calculator outweigh the harms?

Output: they identify high risk patients b etter than provider judgment alone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why do the benefits of using a 10 -year risk calculator outweigh the harms?. ### Response: they identify high risk patients b etter than provider judgment alone.


Instruction: What did the Work Group recognize that under - and over -estimation of CV risk is?

Output: a concern

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Work Group recognize that under - and over -estimation of CV risk is?. ### Response: a concern.


Instruction: Under and over-estimation of CV risk is a concern and may lead to improper prescribing of what?

Output: lipid-lowering medications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Under and over-estimation of CV risk is a concern and may lead to improper prescribing of what?. ### Response: lipid-lowering medications.


Instruction: Patients may prefer awareness of their CV risk to make inform ed decisions.

Output: FRS or the PCE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients may prefer awareness of their CV risk to make inform ed decisions.. ### Response: FRS or the PCE.


Instruction: The Work Group decided upon what recommendation?

Output: Reviewed , Amended

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The Work Group decided upon what recommendation?. ### Response: Reviewed , Amended.


Instruction: Recommendation 4: We suggest against the routine use of what?

Output: coronary  artery calcium  testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Recommendation 4: We suggest against the routine use of what?. ### Response: coronary  artery calcium  testing.


Instruction: What is a weak recommendation?

Output: “Weak for

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a weak recommendation?. ### Response: “Weak for.


Instruction: What does CAC stand for?

Output: Coronary artery calcium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CAC stand for?. ### Response: Coronary artery calcium.


Instruction: What can CAC supplement to further refine the risk assessment of CVD and potential need for treatment?

Output: 10 -year risk calculator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can CAC supplement to further refine the risk assessment of CVD and potential need for treatment?. ### Response: 10 -year risk calculator.


Instruction: What would the ideal CV risk assessment correctly reclassify all intermediate risk individuals into?

Output: a low  or high risk category

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would the ideal CV risk assessment correctly reclassify all intermediate risk individuals into?. ### Response: a low  or high risk category.


Instruction: What is the greatest potential benefit for any test that improves the CVD?

Output: Individuals at intermediate CV risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the greatest potential benefit for any test that improves the CVD?. ### Response: Individuals at intermediate CV risk.


Instruction: What is the VA/DoD Clinical Practice Guideline for the Diagnosis and Management of Hypertension in the Primary Care Setting March 2020 Page 10 of 134 providers within the VA and DoD healthcare systems?

Output: KQs) of the most clinical relevance, importance, and interest for the diagnosis  and management of patients with HTN . The Champions and the Work Group also provided direction on inclusion and exclusion criteria for the evidence review and assessed  the level and quality of the evidence. The amount of new scientific evidence that had accumulated since the previous version of the CPG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for the Diagnosis and Management of Hypertension in the Primary Care Setting March 2020 Page 10 of 134 providers within the VA and DoD healthcare systems?. ### Response: KQs) of the most clinical relevance, importance, and interest for the diagnosis  and management of patients with HTN . The Champions and the Work Group also provided direction on inclusion and exclusion criteria for the evidence review and assessed  the level and quality of the evidence. The amount of new scientific evidence that had accumulated since the previous version of the CPG.


Instruction: What are the Champions and Workforces?

Output: Identifying  appropriate disciplines of individuals to be included as part of the Work Group  • Directing and coordinating the Work Group  • Participating throughout the guideline development and review processes  The VA Office of Quality, Safety and Value, in collaboration with the Office of Evidence Based Practice, U.S. Army Medical Command, the proponent for CPGs for the DoD, identified four  clinical leaders

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Champions and Workforces?. ### Response: Identifying  appropriate disciplines of individuals to be included as part of the Work Group  • Directing and coordinating the Work Group  • Participating throughout the guideline development and review processes  The VA Office of Quality, Safety and Value, in collaboration with the Office of Evidence Based Practice, U.S. Army Medical Command, the proponent for CPGs for the DoD, identified four  clinical leaders.


Instruction: Who were responsible for identifying the most clinical relevance, importance, and interest for the diagnosis and management of patients with HTN?

Output: the Champions and Work Group members

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who were responsible for identifying the most clinical relevance, importance, and interest for the diagnosis and management of patients with HTN?. ### Response: the Champions and Work Group members.


Instruction: What did the Champions and the Work Group provide?

Output: direction on inclusion and exclusion criteria for the evidence review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Champions and the Work Group provide?. ### Response: direction on inclusion and exclusion criteria for the evidence review.


Instruction: Who provided direction on inclusion and exclusion criteria for the evidence review?

Output: The Champions and the Work Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who provided direction on inclusion and exclusion criteria for the evidence review?. ### Response: The Champions and the Work Group.


Instruction: Who assessed the level and quality of the evidence?

Output: The Champions and the Work Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who assessed the level and quality of the evidence?. ### Response: The Champions and the Work Group.


Instruction: The amount of new scientific evidence that had accumulated since the previous version of the CPG was taken into account?

Output: identification of the KQs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The amount of new scientific evidence that had accumulated since the previous version of the CPG was taken into account?. ### Response: identification of the KQs.


Instruction: What was also taken into consideration in the identification of the KQs?

Output: The amount of new scientific evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was also taken into consideration in the identification of the KQs?. ### Response: The amount of new scientific evidence.


Instruction: What did the Champions assist in?

Output: Identifying  appropriate disciplines of individuals to be included as part of the Work Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Champions assist in?. ### Response: Identifying  appropriate disciplines of individuals to be included as part of the Work Group.


Instruction: How many CPGs did the VA Office of Quality, Safety and Value identify for the DoD?

Output: four

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many CPGs did the VA Office of Quality, Safety and Value identify for the DoD?. ### Response: four.


Instruction: What is the name of the organization that is responsible for the development of CPG guidelines?

Output: The Lewin Team

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that is responsible for the development of CPG guidelines?. ### Response: The Lewin Team.


Instruction: Who is the proponent of the CPG program?

Output: U.S. Army Medical Command

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the proponent of the CPG program?. ### Response: U.S. Army Medical Command.


Instruction: How many PGs were identified by the VA?

Output: 134

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many PGs were identified by the VA?. ### Response: 134.


Instruction: How many clinical leaders did the proponent of CPGs for the DoD identify as Champions for?

Output: four

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many clinical leaders did the proponent of CPGs for the DoD identify as Champions for?. ### Response: four.


Instruction: What are the names of the four clinical leaders from the VA?

Output: William Cushman, MD and Dan Berlowitz, MD, MPH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the four clinical leaders from the VA?. ### Response: William Cushman, MD and Dan Berlowitz, MD, MPH.


Instruction: Who were the Champions for the 2020 VA/DoD HTN CPG?

Output: four  clinical leaders

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who were the Champions for the 2020 VA/DoD HTN CPG?. ### Response: four  clinical leaders.


Instruction: What did the VA and DoD contract The Lewin Team to support?

Output: development of this CPG and conduct the evidence review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the VA and DoD contract The Lewin Team to support?. ### Response: development of this CPG and conduct the evidence review.


Instruction: What did the VA and DoD do to support the development of this CPG and conduct the evidence review?

Output: Formulating and prioritizing KQs and defining critical outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the VA and DoD do to support the development of this CPG and conduct the evidence review?. ### Response: Formulating and prioritizing KQs and defining critical outcomes.


Instruction: When was the first conference call held?

Output: October  2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the first conference call held?. ### Response: October  2018.


Instruction: What was the name of the COR?

Output: contracting officer’s representative

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the COR?. ### Response: contracting officer’s representative.


Instruction: What is the DoD Office of Evidence Based Practice called?

Output: Champions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the DoD Office of Evidence Based Practice called?. ### Response: Champions.


Instruction: What are the roles and responsibilities of the Champions?

Output: identifying the key questions (KQs) of the most clinical relevance, importance, and interest for the diagnosis  and management of patients with HTN

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the roles and responsibilities of the Champions?. ### Response: identifying the key questions (KQs) of the most clinical relevance, importance, and interest for the diagnosis  and management of patients with HTN.


Instruction: What is SR?

Output: systematic review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SR?. ### Response: systematic review.


Instruction: What did the group identify that are important and relevant to the management of HTN?

Output: clinical specialties and areas of expertise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the group identify that are important and relevant to the management of HTN?. ### Response: clinical specialties and areas of expertise.


Instruction: What was recruited from the Work Group members?

Output: clinical specialties and areas of expertise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was recruited from the Work Group members?. ### Response: clinical specialties and areas of expertise.


Instruction: What were the specialties and clinical areas of interest?

Output: internal medicine, family medicine, nephrology, cardiology, nutrition, nursing, and pharmacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the specialties and clinical areas of interest?. ### Response: internal medicine, family medicine, nephrology, cardiology, nutrition, nursing, and pharmacy.


Instruction: How was the guideline development process for the 2020 VA/DoD HTN CPG update?

Output: consisted of the following steps

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the guideline development process for the 2020 VA/DoD HTN CPG update?. ### Response: consisted of the following steps.


Instruction: What were the steps for the 2020 VA/DoD HTN CPG update?

Output: 1. Formulating and prioritizing KQs and defining critical outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the steps for the 2020 VA/DoD HTN CPG update?. ### Response: 1. Formulating and prioritizing KQs and defining critical outcomes.


Instruction: What was the name of the group that was convened for the patient focus group?

Output: Champions and Work Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the group that was convened for the patient focus group?. ### Response: Champions and Work Group.


Instruction: What refers to an unexplained heterogeneity of results for an outcome across different studies?

Output: Inconsistency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What refers to an unexplained heterogeneity of results for an outcome across different studies?. ### Response: Inconsistency.


Instruction: When estimates of the treatment effect across studies differ widely, this suggests true differences in what?

Output: the underlying treatment effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When estimates of the treatment effect across studies differ widely, this suggests true differences in what?. ### Response: the underlying treatment effect.


Instruction: What may be due to differences in populations, settings or doses?

Output: underlying treatment effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be due to differences in populations, settings or doses?. ### Response: underlying treatment effect.


Instruction: How was the quality of evidence for an outcome downgraded?

Output: When heterogeneity existed within an outcome (chi -squared p<0.1, or I2>50%), but no plausible explanation could be found

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the quality of evidence for an outcome downgraded?. ### Response: When heterogeneity existed within an outcome (chi -squared p<0.1, or I2>50%), but no plausible explanation could be found.


Instruction: What was given a'serious' score if the I2 was 50 –74%?

Output: Inconsistency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was given a'serious' score if the I2 was 50 –74%?. ### Response: Inconsistency.


Instruction: What is a score of 1 if the I2 was 50 – 74%?

Output: −1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a score of 1 if the I2 was 50 – 74%?. ### Response: −1.


Instruction: What is another name for a very serious score if it was 75% or more?

Output: −2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for a very serious score if it was 75% or more?. ### Response: −2.


Instruction: What percentage of the I250% was taken into account by the committee?

Output: prespecifie d subgroup analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the I250% was taken into account by the committee?. ### Response: prespecifie d subgroup analysis.


Instruction: The committee considered whether to make recommendations on new outcomes based on what?

Output: subgroups defined by the assumed explanatory

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committee considered whether to make recommendations on new outcomes based on what?. ### Response: subgroups defined by the assumed explanatory.


Instruction: What is the role of cardiovascular magnetic resonance in adults with congenital heart disease?

Output: Kilner PJ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of cardiovascular magnetic resonance in adults with congenital heart disease?. ### Response: Kilner PJ.


Instruction: What is Boxt LM's role in magnetic resonance and computed tomographic eval-uation?

Output: congenital heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Boxt LM's role in magnetic resonance and computed tomographic eval-uation?. ### Response: congenital heart disease.


Instruction: When was J Magn Reson Imaging's 19:827-47?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was J Magn Reson Imaging's 19:827-47?. ### Response: 2004.


Instruction: What is the clinical value of real-time three-dimensional echocardiography for right ven-tricular quantification in congenital heart disease: validation with cardiac magnetic resonance imaging?

Output: S3.4.4-16

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the clinical value of real-time three-dimensional echocardiography for right ven-tricular quantification in congenital heart disease: validation with cardiac magnetic resonance imaging?. ### Response: S3.4.4-16.


Instruction: What is a role of magnetic reso-nance angiography in?

Output: the diagnosis of major aortopulmonary col-lateral arteries and partial anomalous pulmonary venous drainage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a role of magnetic reso-nance angiography in?. ### Response: the diagnosis of major aortopulmonary col-lateral arteries and partial anomalous pulmonary venous drainage.


Instruction: What is the role of magnetic reso-nance angiography in the diagnosis of major aortopulmonary col-lateral arteries and partial anomalous pulmonary venous drainage?

Output: Role

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of magnetic reso-nance angiography in the diagnosis of major aortopulmonary col-lateral arteries and partial anomalous pulmonary venous drainage?. ### Response: Role.


Instruction: When was Circulation.109:207–14.3.4.5?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Circulation.109:207–14.3.4.5?. ### Response: 2004.


Instruction: What is an increasing source of radiation exposure?

Output: Computed tomography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an increasing source of radiation exposure?. ### Response: Computed tomography.


Instruction: What year did J Med publish 357:2277–84?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did J Med publish 357:2277–84?. ### Response: 2007.


Instruction: What is the name of the second-generation dual-source computed tomography used in adult congenital heart disease imaging?

Output: S3.4.4-14

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the second-generation dual-source computed tomography used in adult congenital heart disease imaging?. ### Response: S3.4.4-14.


Instruction: Which year did Congenit Heart Dis publish 7:516–25.3.4.6?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which year did Congenit Heart Dis publish 7:516–25.3.4.6?. ### Response: 2012.


Instruction: Who wrote the paper Cardiac Catheterization?

Output: Moore JW, Vincent RN, Beekman RH 3rd

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote the paper Cardiac Catheterization?. ### Response: Moore JW, Vincent RN, Beekman RH 3rd.


Instruction: What is the name of the initial report from the National Cardiovascular Data Registry?

Output: Beekman RH 3rd, et al. Procedural results and safety of common interventional procedures in congenital heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the initial report from the National Cardiovascular Data Registry?. ### Response: Beekman RH 3rd, et al. Procedural results and safety of common interventional procedures in congenital heart disease.


Instruction: What are the results of common interventional procedures in congenital heart disease?

Output: Procedural results and safety

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of common interventional procedures in congenital heart disease?. ### Response: Procedural results and safety.


Instruction: What are the results of the C3PO?

Output: Adverse events rates and risk factors in adults undergoing cardiac catheterization at pedi-atric hospitals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of the C3PO?. ### Response: Adverse events rates and risk factors in adults undergoing cardiac catheterization at pedi-atric hospitals.


Instruction: What is a risk factor for cardiac catheterization in adults at pedi-atric hospitals?

Output: Adverse events rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for cardiac catheterization in adults at pedi-atric hospitals?. ### Response: Adverse events rates.


Instruction: Who cares for the adult with congenital heart disease in an adult catheterization laboratory by pediatric interventionalists?

Output: Sutton NJ, Greenberg MA, Menegus MA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who cares for the adult with congenital heart disease in an adult catheterization laboratory by pediatric interventionalists?. ### Response: Sutton NJ, Greenberg MA, Menegus MA.


Instruction: What did pediatric interventionalists focus on in 2013?

Output: safety and efficacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did pediatric interventionalists focus on in 2013?. ### Response: safety and efficacy.


Instruction: What is the impact of clinical variables and hospital procedure volume on in-hospital adverse events?

Output: Percutaneous clo-sure of patent foramen ovale and atrial septal defect in adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact of clinical variables and hospital procedure volume on in-hospital adverse events?. ### Response: Percutaneous clo-sure of patent foramen ovale and atrial septal defect in adults.


Instruction: In-hospital adverse events.

Output: Percutaneous clo-sure of patent foramen ovale and atrial septal defect in adults: the impact of clinical variables and hospital procedure volume

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In-hospital adverse events.. ### Response: Percutaneous clo-sure of patent foramen ovale and atrial septal defect in adults: the impact of clinical variables and hospital procedure volume.


Instruction: What is the name of the study that combines noninvasive coronary angiography with multidetector computed tomography?

Output: Predictive value

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that combines noninvasive coronary angiography with multidetector computed tomography?. ### Response: Predictive value.


Instruction: What does S3.4.6-5 do?

Output: Predictive value of noninvasive coronary angiography with multidetector computed tomography to detect significant coronary stenosis before valve surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does S3.4.6-5 do?. ### Response: Predictive value of noninvasive coronary angiography with multidetector computed tomography to detect significant coronary stenosis before valve surgery.


Instruction: What did Gilard M, Cornily J-C, Pennec P-Y, et al. use in the preoperative assessment of coronary heart disease?

Output: multislice computed tomography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Gilard M, Cornily J-C, Pennec P-Y, et al. use in the preoperative assessment of coronary heart disease?. ### Response: multislice computed tomography.


Instruction: When was this article published?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this article published?. ### Response: April 28, 2023.


Instruction: What should be measured in the fasting state?

Output: Striglycerides

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be measured in the fasting state?. ### Response: Striglycerides.


Instruction: Patients with RA who are untreated or who have high disease activity generally have decreased levels of TC, triglycerides, HDL-C, and what else?

Output: LDL-C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with RA who are untreated or who have high disease activity generally have decreased levels of TC, triglycerides, HDL-C, and what else?. ### Response: LDL-C.


Instruction: What is a possible cause of the lower lipid levels?

Output: increased inflammation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a possible cause of the lower lipid levels?. ### Response: increased inflammation.


Instruction: What is an example of a cho-lesterol efflux capacity of HDL-C?

Output: S4.5.5-22

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a cho-lesterol efflux capacity of HDL-C?. ### Response: S4.5.5-22.


Instruction: What is methotrexate associated with?

Output: an increase in and normalization of lipid levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is methotrexate associated with?. ### Response: an increase in and normalization of lipid levels.


Instruction: What is the ratio of TC to HDL-C?

Output: reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ratio of TC to HDL-C?. ### Response: reduction.


Instruction: When should ASCVD risk estimation be repeated?

Output: when the patient has a stable and low

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When should ASCVD risk estimation be repeated?. ### Response: when the patient has a stable and low.


Instruction: What should be repeated when the patient has a stable and low disease activity with normalization of their lipid lev-els?

Output: ASCVD risk estimation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be repeated when the patient has a stable and low disease activity with normalization of their lipid lev-els?. ### Response: ASCVD risk estimation.


Instruction: Lower lipid levels measured during high disease activity may lead to a significant underestimation of what risk for patients with RA?

Output: ASCVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Lower lipid levels measured during high disease activity may lead to a significant underestimation of what risk for patients with RA?. ### Response: ASCVD.


Instruction: What is a clinician-patient risk discussion recommended before initiation of statin therapy?

Output: to review net clinical benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a clinician-patient risk discussion recommended before initiation of statin therapy?. ### Response: to review net clinical benefit.


Instruction: What are the Online Data Supplements 40 and 41?

Output: Recommendations for Statin Safety and Statin-Associated Side EffectsReferenced studies that support recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Online Data Supplements 40 and 41?. ### Response: Recommendations for Statin Safety and Statin-Associated Side EffectsReferenced studies that support recommendations.


Instruction: What does SAMS stand for?

Output: statin-associated muscle symptoms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does SAMS stand for?. ### Response: statin-associated muscle symptoms.


Instruction: What is a thorough assessment of statin-associated muscle symptoms?

Output: recommended

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a thorough assessment of statin-associated muscle symptoms?. ### Response: recommended.


Instruction: What is the term for muscle symptoms?

Output: statin-associated muscle symptoms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for muscle symptoms?. ### Response: statin-associated muscle symptoms.


Instruction: What is a thorough assessment of symptoms recommended?

Output: statin-associated muscle symptoms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a thorough assessment of symptoms recommended?. ### Response: statin-associated muscle symptoms.


Instruction: What type of diabetes is recommended before initiation of treatment?

Output: RA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diabetes is recommended before initiation of treatment?. ### Response: RA.


Instruction: What is recommended in patients with statin-associated side effects that are not severe?

Output: to reassess and to rechallenge to achieve a maximal LDL-C lowering by modified dosing regimen, an alternate statin or in combination with nonstatin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended in patients with statin-associated side effects that are not severe?. ### Response: to reassess and to rechallenge to achieve a maximal LDL-C lowering by modified dosing regimen, an alternate statin or in combination with nonstatin therapy.


Instruction: What type of therapy is recommended in patients with diabetes mellitus risk?

Output: anti-inflammatory medications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is recommended in patients with diabetes mellitus risk?. ### Response: anti-inflammatory medications.


Instruction: What are the core principles of regular moderate-intensity physical activity?

Output: maintaining a healthy dietary pattern, and sustaining modest weight loss

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the core principles of regular moderate-intensity physical activity?. ### Response: maintaining a healthy dietary pattern, and sustaining modest weight loss.


Instruction: What are the core principles of regular moderate-intensity physical activity, maintaining a healthy dietary pattern, and sustaining modest weight loss?

Output: net clinical benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the core principles of regular moderate-intensity physical activity, maintaining a healthy dietary pattern, and sustaining modest weight loss?. ### Response: net clinical benefit.


Instruction: In patients treated with statins, it is recommended to measure what in individuals with severe statin-dependent illness?

Output: creatine kinase levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients treated with statins, it is recommended to measure what in individuals with severe statin-dependent illness?. ### Response: creatine kinase levels.


Instruction: What is NICE 2018?

Output: All rights reserved

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE 2018?. ### Response: All rights reserved.


Instruction: Who is subject to Notice of rights?

Output: Chronic Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is subject to Notice of rights?. ### Response: Chronic Heart Failure.


Instruction: What is the ISBN number of the study?

Output: 978 -1-4731 -3093 -7 377

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ISBN number of the study?. ### Response: 978 -1-4731 -3093 -7 377.


Instruction: How many studies contributed to the finding Design Criteria Rating Overall assessment of confidence 2a Poor Co -ordination Between Services 6 29, 47, 126,#2771, 225, 325 2 x interviews of pt with advanced CHF and their care network

Output: No of studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies contributed to the finding Design Criteria Rating Overall assessment of confidence 2a Poor Co -ordination Between Services 6 29, 47, 126,#2771, 225, 325 2 x interviews of pt with advanced CHF and their care network. ### Response: No of studies.


Instruction: Interviews of pt with advanced CHF and their care network What do people with heart failure experience as being poorly co-ordinated?

Output: the healthcare system

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Interviews of pt with advanced CHF and their care network What do people with heart failure experience as being poorly co-ordinated?. ### Response: the healthcare system.


Instruction: What does the lack of co-ordination of the healthcare system lead to?

Output: increased burdens on them

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the lack of co-ordination of the healthcare system lead to?. ### Response: increased burdens on them.


Instruction: What did being poorly coordinated lead to?

Output: increased burdens on them

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did being poorly coordinated lead to?. ### Response: increased burdens on them.


Instruction: What resulted in uncertainty and loss of confidence?

Output: People with heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What resulted in uncertainty and loss of confidence?. ### Response: People with heart failure.


Instruction: No or very minor concerns Relevance minor concerns Adequacy no or very small concerns 2b Models to co -ordinate care 5 124, 133, 202, 294, 325 2 x interviews of mix of what?

Output: HCP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No or very minor concerns Relevance minor concerns Adequacy no or very small concerns 2b Models to co -ordinate care 5 124, 133, 202, 294, 325 2 x interviews of mix of what?. ### Response: HCP.


Instruction: Interviews of pt and their care networks Health professionals were aware of several models that could be used to better what?

Output: co -ordinate care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Interviews of pt and their care networks Health professionals were aware of several models that could be used to better what?. ### Response: co -ordinate care.


Instruction: What type of nurses are used to facilitate cross-boundary working?

Output: heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of nurses are used to facilitate cross-boundary working?. ### Response: heart failure.


Instruction: What kind of work can be done between primary and secondary care via a shared care agreement?

Output: conjoint

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What kind of work can be done between primary and secondary care via a shared care agreement?. ### Response: conjoint.


Instruction: What type of concerns are moderately concerned about?

Output: minor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of concerns are moderately concerned about?. ### Response: minor.


Instruction: What kind of concerns do moderate concerns have about adequate?

Output: no or very minor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What kind of concerns do moderate concerns have about adequate?. ### Response: no or very minor.


Instruction: What is another word for "Strong recommendation, moderate quality evidence"?

Output: NOACs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another word for "Strong recommendation, moderate quality evidence"?. ### Response: NOACs.


Instruction: If TTR 65% - implement what to improve INR control?

Output: additional measures (more regular INR tests; reviewmedication adherence; address other factors known toinﬂuence INR control; education/counselling

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: If TTR 65% - implement what to improve INR control?. ### Response: additional measures (more regular INR tests; reviewmedication adherence; address other factors known toinﬂuence INR control; education/counselling.


Instruction: In patients with prior unprovoked bleeding,warfarin-associated bleeding or at high risk of bleeding, we suggest using what?

Output: apixaban, edoxaban, ordabigatran 110 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with prior unprovoked bleeding,warfarin-associated bleeding or at high risk of bleeding, we suggest using what?. ### Response: apixaban, edoxaban, ordabigatran 110 mg.


Instruction: What are the only drugs that can be used in patients with prior gastrointestinal bleeding?

Output: apixaban or dabigatran

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the only drugs that can be used in patients with prior gastrointestinal bleeding?. ### Response: apixaban or dabigatran.


Instruction: What is the only drug that can reduce major bleeding in patients?

Output: warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the only drug that can reduce major bleeding in patients?. ### Response: warfarin.


Instruction: When patients have prior bleeding, what may be preferable?

Output: apixaban or dabigatran 110 mg bid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When patients have prior bleeding, what may be preferable?. ### Response: apixaban or dabigatran 110 mg bid.


Instruction: What are the only NOACs associated without an increased risk of gastrointestinal bleeding compared with warfarin?

Output: apixaban or dabigatran 110 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the only NOACs associated without an increased risk of gastrointestinal bleeding compared with warfarin?. ### Response: apixaban or dabigatran 110 mg.


Instruction: How often is Dabigatran 150 mg twice daily recommended for patients at high risk of stroke?

Output: as only agent/dose with superior ef ﬁcacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often is Dabigatran 150 mg twice daily recommended for patients at high risk of stroke?. ### Response: as only agent/dose with superior ef ﬁcacy.


Instruction: What is the only agent/dose with superior ef ficacy?

Output: Dabigatran

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the only agent/dose with superior ef ficacy?. ### Response: Dabigatran.


Instruction: What would need to be assessed andpatients monitored?

Output: bleeding risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would need to be assessed andpatients monitored?. ### Response: bleeding risk.


Instruction: For patients with non-valvular AF, when VKAs are used, what should the target be?

Output: INR 2.0-3.0

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For patients with non-valvular AF, when VKAs are used, what should the target be?. ### Response: INR 2.0-3.0.


Instruction: Withattention to individual TTR, ideally 70% (Ungradedconsensus-based statement).

Output: non-valvular AF, when VKAs areused, we suggest the target should be INR 2.0-3.0

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Withattention to individual TTR, ideally 70% (Ungradedconsensus-based statement).. ### Response: non-valvular AF, when VKAs areused, we suggest the target should be INR 2.0-3.0.


Instruction: What percentage of TTR is considered to be sub-optimal?

Output: <65-70%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of TTR is considered to be sub-optimal?. ### Response: <65-70%).


Instruction: What should be done if the TTR reaches 65-70%?

Output: implement additional measures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be done if the TTR reaches 65-70%?. ### Response: implement additional measures.


Instruction: How do you review medication adherence?

Output: more regular INR tests

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do you review medication adherence?. ### Response: more regular INR tests.


Instruction: What is mandatory?

Output: Anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is mandatory?. ### Response: Anticoagulation.


Instruction: What is not appropriate for rhythms that break or recur spontaneously?

Output: synchronized cardioversion or rapid atrial pacing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not appropriate for rhythms that break or recur spontaneously?. ### Response: synchronized cardioversion or rapid atrial pacing.


Instruction: IV indicates intravenous.

Output: *Anticoagulation as per guideline is mandatory. †

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: IV indicates intravenous.. ### Response: *Anticoagulation as per guideline is mandatory. †.


Instruction: How many drugs are listed alphabetically?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many drugs are listed alphabetically?. ### Response: *.


Instruction: What should be combined with AV nodal-blocking agents to reduce risk of 1:1 conduction during atrial flutter?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be combined with AV nodal-blocking agents to reduce risk of 1:1 conduction during atrial flutter?. ### Response: †.


Instruction: What is ischemic heart disease?

Output: structural heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ischemic heart disease?. ### Response: structural heart disease.


Instruction: When was this article downloaded?

Output: April 23, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this article downloaded?. ### Response: April 23, 2023.


Instruction: What is the most impor -tant risk factor for early seizures?

Output: Cortical involvement of ICH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most impor -tant risk factor for early seizures?. ### Response: Cortical involvement of ICH.


Instruction: In a large single-center study, what significantly reduced the number of clinical seizures after lobar ICH?

Output: prophylactic antiseizure drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In a large single-center study, what significantly reduced the number of clinical seizures after lobar ICH?. ### Response: prophylactic antiseizure drugs.


Instruction: Prospective and population-based studies have shown no asso-ciation between clinical seizures and neurological outcome or mortality.

Output: a recent study found no association between antiseizure drugs and out-come

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Prospective and population-based studies have shown no asso-ciation between clinical seizures and neurological outcome or mortality.. ### Response: a recent study found no association between antiseizure drugs and out-come.


Instruction: What is the term for continuous electroencephalography?

Output: EEG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for continuous electroencephalography?. ### Response: EEG.


Instruction: What percentage of ICH patients have electrographic seizures?

Output: 28% to 31%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of ICH patients have electrographic seizures?. ### Response: 28% to 31%.


Instruction: Most studies suggest that prophylactic antiseizure medications are effective?

Output: Prophylactic antiseizure medication is not recom-mended

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Most studies suggest that prophylactic antiseizure medications are effective?. ### Response: Prophylactic antiseizure medication is not recom-mended.


Instruction: What is phenytoin primarily associated with?

Output: increased death and disability in ICH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is phenytoin primarily associated with?. ### Response: increased death and disability in ICH.


Instruction: What did a recent study find no association between antiseizure drugs and out-come in those who survived beyond 5 days?

Output: ICH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a recent study find no association between antiseizure drugs and out-come in those who survived beyond 5 days?. ### Response: ICH.


Instruction: What did a small randomized trial of prophylactic treatment with valproic acid show no reduc-tion in incident seizures over 1-year follow-up?

Output: 19.5% in the treatment group, 22.2% in the placebo group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a small randomized trial of prophylactic treatment with valproic acid show no reduc-tion in incident seizures over 1-year follow-up?. ### Response: 19.5% in the treatment group, 22.2% in the placebo group.


Instruction: What percentage of incident seizures were reduced in the treatment group?

Output: 19.5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of incident seizures were reduced in the treatment group?. ### Response: 19.5%.


Instruction: How much of the incident seizures in the placebo group were reduced?

Output: 22.2%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the incident seizures in the placebo group were reduced?. ### Response: 22.2%.


Instruction: Which type of anticonvulsant medication has been used to treat seizures?

Output: Prophylactic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which type of anticonvulsant medication has been used to treat seizures?. ### Response: Prophylactic.


Instruction: What is the P value of the placebo group?

Output: 0.8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the P value of the placebo group?. ### Response: 0.8.


Instruction: What should be treated with antisei-zure drugs in patients with a change in mental status?

Output: Clinical seizures or electrographic seizures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be treated with antisei-zure drugs in patients with a change in mental status?. ### Response: Clinical seizures or electrographic seizures.


Instruction: Continuous EEG monitoring should be considered in what type of patients?

Output: ICH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Continuous EEG monitoring should be considered in what type of patients?. ### Response: ICH.


Instruction: What percentage of young patients with ICH have epilepsy?

Output: 10%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of young patients with ICH have epilepsy?. ### Response: 10%.


Instruction: What is the risk of poststroke epilepsia in older patients?

Output: less

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of poststroke epilepsia in older patients?. ### Response: less.


Instruction: How many risk factors include stroke severity and cortical location of the brain?

Output: 169,170

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many risk factors include stroke severity and cortical location of the brain?. ### Response: 169,170.


Instruction: What are some risk factors for epilepsy?

Output: stroke severity, cortical location of the hematoma, and delayed initial seizures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some risk factors for epilepsy?. ### Response: stroke severity, cortical location of the hematoma, and delayed initial seizures.


Instruction: What is there no data to sug-gest that early use of antiseizure drugs will prevent?

Output: lesion-related epilepsy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is there no data to sug-gest that early use of antiseizure drugs will prevent?. ### Response: lesion-related epilepsy.


Instruction: What should be treated with antiseizure drugs?

Output: electrographic seizures on EEG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be treated with antiseizure drugs?. ### Response: electrographic seizures on EEG.


Instruction: What should patients with a change in mental status who are found to have electrographic seizures on EEG receive?

Output: antisei-zure drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients with a change in mental status who are found to have electrographic seizures on EEG receive?. ### Response: antisei-zure drugs.


Instruction: What is probably indicated in ICH patients with depressed mental status that is out of proportion to the degree of brain injury?

Output: Continuous EEG monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is probably indicated in ICH patients with depressed mental status that is out of proportion to the degree of brain injury?. ### Response: Continuous EEG monitoring.


Instruction: What is not recom-mended (Class III; Level of Evidence B)?

Output: Prophylactic antiseizure medication

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recom-mended (Class III; Level of Evidence B)?. ### Response: Prophylactic antiseizure medication.


Instruction: When was the guideline downloaded?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the guideline downloaded?. ### Response: April 28, 2023.


Instruction: Insufficient evidence to suggest an alt ernativ e option?

Output: lack of e vidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Insufficient evidence to suggest an alt ernativ e option?. ### Response: lack of e vidence.


Instruction: The committ ee agr eed t hat t the choice of tr eatment should still be made based on what?

Output: t heir experience

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committ ee agr eed t hat t the choice of tr eatment should still be made based on what?. ### Response: t heir experience.


Instruction: What is NICE's guideline on chronic hear t failure?

Output: advice on using beta-block ers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE's guideline on chronic hear t failure?. ### Response: advice on using beta-block ers.


Instruction: What is a voiding rat e-limiting calcium-channel block er?

Output: diltiaz em and v erapamil

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a voiding rat e-limiting calcium-channel block er?. ### Response: diltiaz em and v erapamil.


Instruction: What block ers are used in people who have atrial fibrillation wit h hear t failure?

Output: erapamil

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What block ers are used in people who have atrial fibrillation wit h hear t failure?. ### Response: erapamil.


Instruction: The committ ee agreed t hat digo xin monot herap y for non-par oxysmal atrial fibrosis should continue?

Output: alr eady happens in practice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committ ee agreed t hat digo xin monot herap y for non-par oxysmal atrial fibrosis should continue?. ### Response: alr eady happens in practice.


Instruction: What should be considered for people who ar e sedentar y?

Output: digo xin monot herap y for non-par oxysmal atrial fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered for people who ar e sedentar y?. ### Response: digo xin monot herap y for non-par oxysmal atrial fibrillation.


Instruction: Based on their experience, t he committ ee agr eed to hat it ma y also be consider ed as a tr eatment option when ot her rat e-limiting drugs are e not suitable?

Output: t heir experience, t he committ ee agr eed t hat it ma y also be consider ed as a tr eatment option when ot her rat e-limiting drugs ar e not suitable, so t hey expanded t he recommendation in the pr evious guideline t o also co ver these cir cumstances

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Based on their experience, t he committ ee agr eed to hat it ma y also be consider ed as a tr eatment option when ot her rat e-limiting drugs are e not suitable?. ### Response: t heir experience, t he committ ee agr eed t hat it ma y also be consider ed as a tr eatment option when ot her rat e-limiting drugs ar e not suitable, so t hey expanded t he recommendation in the pr evious guideline t o also co ver these cir cumstances.


Instruction: What are rat e-limiting drugs not suitable for?

Output: cir cumstances

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are rat e-limiting drugs not suitable for?. ### Response: cir cumstances.


Instruction: What are some clinicians feel that digo xin monot herap y is oft en better?

Output: improving sympt oms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some clinicians feel that digo xin monot herap y is oft en better?. ### Response: improving sympt oms.


Instruction: What is oft en bett er than alt ernativ es for improving sympt oms?

Output: digo xin monot herap y

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is oft en bett er than alt ernativ es for improving sympt oms?. ### Response: digo xin monot herap y.


Instruction: The lack of evidence curr ently available meant t he recommendation f or digo xin was not e xpanded to cover fur ther gr oups of what?

Output: people

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The lack of evidence curr ently available meant t he recommendation f or digo xin was not e xpanded to cover fur ther gr oups of what?. ### Response: people.


Instruction: In the absence of new evidence, t he committ ee also agr eed wit h what if initial monot herap y fails?

Output: the existing recommendation f or combination t herap y options

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the absence of new evidence, t he committ ee also agr eed wit h what if initial monot herap y fails?. ### Response: the existing recommendation f or combination t herap y options.


Instruction: What was lacking in evidence on long-t erm rat e contr ol?

Output: e vidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was lacking in evidence on long-t erm rat e contr ol?. ### Response: e vidence.


Instruction: What did the committ ee w ere awar e of numer ous serious side eff ects associat?

Output: amiodar one

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committ ee w ere awar e of numer ous serious side eff ects associat?. ### Response: amiodar one.


Instruction: What are some of the side effects of amiodar one?

Output: thyroid, lung and ner ve damage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the side effects of amiodar one?. ### Response: thyroid, lung and ner ve damage.


Instruction: What side effects are associated with long-t erm use?

Output: thyroid, lung and ner ve damage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What side effects are associated with long-t erm use?. ### Response: thyroid, lung and ner ve damage.


Instruction: Which side effect is irreversible?

Output: amiodar one

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which side effect is irreversible?. ### Response: amiodar one.


Instruction: What were the most common side effects of amiodar one?

Output: thyroid, lung and ner ve damage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the most common side effects of amiodar one?. ### Response: thyroid, lung and ner ve damage.


Instruction: What should be used only as an int erim t herap?

Output: Amiodar one

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be used only as an int erim t herap?. ### Response: Amiodar one.


Instruction: What should only be used as an int erim t herap y?

Output: Amiodar one

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should only be used as an int erim t herap y?. ### Response: Amiodar one.


Instruction: What should not usually be tak en for longer than 12 mont hs?

Output: Amiodar one

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not usually be tak en for longer than 12 mont hs?. ### Response: Amiodar one.


Instruction: How the r ecommendations mig ht affect practice?

Output: r eflect curr ent practice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How the r ecommendations mig ht affect practice?. ### Response: r eflect curr ent practice.