Instruction: The signs in heart failure could be due to what?

Output: pulmonary and systemic congestion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The signs in heart failure could be due to what?. ### Response: pulmonary and systemic congestion.


Instruction: What could be the cause of heart failure?

Output: pulmonary and systemic congestion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could be the cause of heart failure?. ### Response: pulmonary and systemic congestion.


Instruction: There is no single diagnostic test for heart failure, and diagnosis relies on a combination of what?

Output: history, physical examination and appropriate investigations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is no single diagnostic test for heart failure, and diagnosis relies on a combination of what?. ### Response: history, physical examination and appropriate investigations.


Instruction: What type of heart failure is the subject of separate guidance?

Output: heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of heart failure is the subject of separate guidance?. ### Response: heart failure.


Instruction: What is NICE Acute Heart Failure: diagnosis and management?

Output: separate guidance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE Acute Heart Failure: diagnosis and management?. ### Response: separate guidance.


Instruction: What percentage of patients with heart failure suffer an acute decompensation?

Output: ≈65%),

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients with heart failure suffer an acute decompensation?. ### Response: ≈65%),.


Instruction: What is the most common complaint of heart failure patients?

Output: breathlessness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common complaint of heart failure patients?. ### Response: breathlessness.


Instruction: What is the most common complaint of heart failure?

Output: breathlessness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common complaint of heart failure?. ### Response: breathlessness.


Instruction: What is another common non-specific symptom that patients consult their doctor with?

Output: fatigue

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another common non-specific symptom that patients consult their doctor with?. ### Response: fatigue.


Instruction: How many people in the UK today have been diagnosed with heart failure 74?

Output: Around 920,000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people in the UK today have been diagnosed with heart failure 74?. ### Response: Around 920,000.


Instruction: What is the average age at first diagnosis of heart failure?

Output: 77 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the average age at first diagnosis of heart failure?. ### Response: 77 years.


Instruction: What is the average age at first diagnosis?

Output: 77 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the average age at first diagnosis?. ### Response: 77 years.


Instruction: How many people have heart failure?

Output: 1 in 35

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people have heart failure?. ### Response: 1 in 35.


Instruction: How many heart failure patients are over the age of 85?

Output: 1 in 7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many heart failure patients are over the age of 85?. ### Response: 1 in 7.


Instruction: What is the prevalence of heart failure in younger age groups?

Output: Less data exists about heart failure in younger age groups but there is increasing recognition that this condition affects a proportion of patients aged less than 65 years 371

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the prevalence of heart failure in younger age groups?. ### Response: Less data exists about heart failure in younger age groups but there is increasing recognition that this condition affects a proportion of patients aged less than 65 years 371.


Instruction: Prevalence of heart failure is rising despite improvements in care?

Output: The prev alence of heart failure is rising overall despite improvements in care through a combination of improved survival of people with ischaemic heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Prevalence of heart failure is rising despite improvements in care?. ### Response: The prev alence of heart failure is rising overall despite improvements in care through a combination of improved survival of people with ischaemic heart disease.


Instruction: Improved survival of people with ischaemic heart disease, more effective treatments for heart failure, and the effects of population ageing 74 are a combination of what?

Output: improvements in care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Improved survival of people with ischaemic heart disease, more effective treatments for heart failure, and the effects of population ageing 74 are a combination of what?. ### Response: improvements in care.


Instruction: The recent rise in the prevalence of what with preserved left ventricular?

Output: heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The recent rise in the prevalence of what with preserved left ventricular?. ### Response: heart failure.


Instruction: What is the most common cause of heart failure?

Output: impairment of the heart ’s action  as a pump supporting the circulation 11, 74, 337. It is caused by str uctural or functional abnormalities of the heart

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common cause of heart failure?. ### Response: impairment of the heart ’s action  as a pump supporting the circulation 11, 74, 337. It is caused by str uctural or functional abnormalities of the heart.


Instruction: Heart failure with preserved left ventricular ejection fraction parallels the rise in obesity and what other co-morbidities?

Output: hypertension, and diabetes mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Heart failure with preserved left ventricular ejection fraction parallels the rise in obesity and what other co-morbidities?. ### Response: hypertension, and diabetes mellitus.


Instruction: Who is the Chair of the ACC/AHA Task Force on Clinical Practice Guidelines?

Output: Methodology and Evidence Review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Chair of the ACC/AHA Task Force on Clinical Practice Guidelines?. ### Response: Methodology and Evidence Review.


Instruction: When possible, what are the recommendations listed in the present guideline based on?

Output: evidence based

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When possible, what are the recommendations listed in the present guideline based on?. ### Response: evidence based.


Instruction: What was included in the initial ex-tensive evidence review?

Output: literature de-rived from research involving human subjects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was included in the initial ex-tensive evidence review?. ### Response: literature de-rived from research involving human subjects.


Instruction: Where was literature de-rived from research involving human subjects published?

Output: English

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where was literature de-rived from research involving human subjects published?. ### Response: English.


Instruction: What is MEDLINE indexed in?

Output: PubMed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is MEDLINE indexed in?. ### Response: PubMed.


Instruction: What is EMBASE?

Output: An initial ex-tensive evidence review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is EMBASE?. ### Response: An initial ex-tensive evidence review.


Instruction: When was the search conducted?

Output: May 1980 to July 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the search conducted?. ### Response: May 1980 to July 2017.


Instruction: What is a risk-enhancing factor for ASCVD?

Output: statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk-enhancing factor for ASCVD?. ### Response: statin therapy.


Instruction: What is an inhibitor for PCSK9?

Output: bile acid seques-trants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an inhibitor for PCSK9?. ### Response: bile acid seques-trants.


Instruction: What is included in the Online Data Supplement?

Output: The final evidence tables

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is included in the Online Data Supplement?. ### Response: The final evidence tables.


Instruction: What was considered by the writing committee during the guideline writing process?

Output: Additional relevant studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was considered by the writing committee during the guideline writing process?. ### Response: Additional relevant studies.


Instruction: What does the Online Data Supplement summarize the evidence used by the writing committee to formulate recommendations?

Output: The final evidence tables

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Online Data Supplement summarize the evidence used by the writing committee to formulate recommendations?. ### Response: The final evidence tables.


Instruction: References selected and published in the present docu-ment are representative and not all-inclusive?

Output: evidence based

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: References selected and published in the present docu-ment are representative and not all-inclusive?. ### Response: evidence based.


Instruction: An independent evidence review committee was commissioned to perform what?

Output: a formal systematic review of critical clinical questions related to cholesterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: An independent evidence review committee was commissioned to perform what?. ### Response: a formal systematic review of critical clinical questions related to cholesterol.


Instruction: What was the purpose of the independent evidence review committee?

Output: to perform a formal systematic review of critical clinical questions related to cholesterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the purpose of the independent evidence review committee?. ### Response: to perform a formal systematic review of critical clinical questions related to cholesterol.


Instruction: What is the Table 1 of the ERC?

Output: cholesterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Table 1 of the ERC?. ### Response: cholesterol.


Instruction: What is the magnitude of benefit in terms of individual endpoints and composite ischemic events?

Output: absolute reduction; NNT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the magnitude of benefit in terms of individual endpoints and composite ischemic events?. ### Response: absolute reduction; NNT.


Instruction: In terms of adverse events (eg cancer, rhabdomyolysis, diabetes, NNT), what is the size of harm?

Output: absolute increase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In terms of adverse events (eg cancer, rhabdomyolysis, diabetes, NNT), what is the size of harm?. ### Response: absolute increase.


Instruction: What is the term for acute coronary syndrome?

Output: ACS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for acute coronary syndrome?. ### Response: ACS.


Instruction: How many participants were involved in large RCTs?

Output: (>1 000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many participants were involved in large RCTs?. ### Response: (>1 000.


Instruction: What was the initial duration of the RCT?

Output: >12 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the initial duration of the RCT?. ### Response: >12 months.


Instruction: What is the acronym for atherosclerotic cardiovascular disease?

Output: ASCVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for atherosclerotic cardiovascular disease?. ### Response: ASCVD.


Instruction: What is MI?

Output: myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is MI?. ### Response: myocardial infarction.


Instruction: What indicates atherosclerotic cardiovascular disease?

Output: ASCVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates atherosclerotic cardiovascular disease?. ### Response: ASCVD.


Instruction: What does CHD mean?

Output: coronary heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CHD mean?. ### Response: coronary heart disease.


Instruction: What is the name of the study?

Output: Study None

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study?. ### Response: Study None.


Instruction: When was the study completed?

Output: April 27, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the study completed?. ### Response: April 27, 2023.


Instruction: Where did the study begin?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where did the study begin?. ### Response: http://ahajournals.org.


Instruction: How many domains of non-health-related measures affect health outcomes?

Output: 5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many domains of non-health-related measures affect health outcomes?. ### Response: 5.


Instruction: What is the ACC/AHA guideline on the Primary Prevention of Cardiovascular Disease?

Output: creening tool to assess 5 domains of non–health-related measures that affect health outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ACC/AHA guideline on the Primary Prevention of Cardiovascular Disease?. ### Response: creening tool to assess 5 domains of non–health-related measures that affect health outcomes.


Instruction: What are some upstream social determinants of health that affect treatment adherence and ASCVD health outcomes?

Output: comorbid mental illness, lack of health literacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some upstream social determinants of health that affect treatment adherence and ASCVD health outcomes?. ### Response: comorbid mental illness, lack of health literacy.


Instruction: What is an example of comorbid mental illness?

Output: upstream social determinants of health

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of comorbid mental illness?. ### Response: upstream social determinants of health.


Instruction: What are some of the health outcomes associated with ASCVD?

Output: comorbid mental illness, lack of health literacy, exposure to adversity (eg, home/community vio-lence, trauma exposures, safety concerns), finan-cial strain, inadequate housing conditions, lack of food security (ie, access to affordable and nutritious food), and inadequate social support

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the health outcomes associated with ASCVD?. ### Response: comorbid mental illness, lack of health literacy, exposure to adversity (eg, home/community vio-lence, trauma exposures, safety concerns), finan-cial strain, inadequate housing conditions, lack of food security (ie, access to affordable and nutritious food), and inadequate social support.


Instruction: What is one of the social determinants systems of care should evaluate?

Output: transportation barriers, the availability of health services

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the social determinants systems of care should evaluate?. ### Response: transportation barriers, the availability of health services.


Instruction: What should systems of care evaluate for the primary prevention of ASCVD?

Output: social determinants of health

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should systems of care evaluate for the primary prevention of ASCVD?. ### Response: social determinants of health.


Instruction: What are not captured by existing CVD risk equations?

Output: Important considerations related to socioeco-nomic disadvantage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are not captured by existing CVD risk equations?. ### Response: Important considerations related to socioeco-nomic disadvantage.


Instruction: Addressing unmet social needs improves management of what?

Output: BP and lipids

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Addressing unmet social needs improves management of what?. ### Response: BP and lipids.


Instruction: What improves management of BP and lipids?

Output: Addressing unmet social needs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What improves management of BP and lipids?. ### Response: Addressing unmet social needs.


Instruction: What highlights the importance of dietary coun-seling and encouraging physical activity?

Output: S2.1-32

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What highlights the importance of dietary coun-seling and encouraging physical activity?. ### Response: S2.1-32.


Instruction: What impedes the efficacy of proven prevention recommendations?

Output: Failure to address the impact of social determinants of health

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What impedes the efficacy of proven prevention recommendations?. ### Response: Failure to address the impact of social determinants of health.


Instruction: What outlines key considerations related to social determinants of health?

Output: Table 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What outlines key considerations related to social determinants of health?. ### Response: Table 2.


Instruction: What are the key considerations related to social determinants of health and ASCVD prevention?

Output: Table 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the key considerations related to social determinants of health and ASCVD prevention?. ### Response: Table 2.


Instruction: What should clinicians routinely assess for adults 40 to 75 years?

Output: traditional cardiovascular risk factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should clinicians routinely assess for adults 40 to 75 years?. ### Response: traditional cardiovascular risk factors.


Instruction: What should clinicians use to calculate 10-year risk of ASCVD?

Output: pooled cohort equations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should clinicians use to calculate 10-year risk of ASCVD?. ### Response: pooled cohort equations.


Instruction: For adults 20 to 39 years of age, it is reasonable to assess traditional asCVD risk factors at least every 4 to 6 years?

Output: S2.2-1,S2.2-2IIa B-NR2.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For adults 20 to 39 years of age, it is reasonable to assess traditional asCVD risk factors at least every 4 to 6 years?. ### Response: S2.2-1,S2.2-2IIa B-NR2..


Instruction: How often should ASCVD risk factors be checked?

Output: every 4 to 6 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often should ASCVD risk factors be checked?. ### Response: every 4 to 6 years.


Instruction: What is the range of risk for borderline and intermediate risk?

Output: ≥7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the range of risk for borderline and intermediate risk?. ### Response: ≥7.


Instruction: What type of intervention is used to guide decisions about preventive interventions?

Output: statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of intervention is used to guide decisions about preventive interventions?. ### Response: statin therapy.


Instruction: In adults at intermediate risk, what is the risk of 10-year ASCVD?

Output: ≥7.5% to <20%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In adults at intermediate risk, what is the risk of 10-year ASCVD?. ### Response: ≥7.5% to <20%.


Instruction: How many patients with heterozygous FH took contemporary statin with or without ezetimibe treatment regimens?

Output: 404

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with heterozygous FH took contemporary statin with or without ezetimibe treatment regimens?. ### Response: 404.


Instruction: What are the independent predictors of incident ASCVD over a 5.5-year follow-up period?

Output: LDL-C levels ≥100 mg/dL (≥2.6 mmol/L)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the independent predictors of incident ASCVD over a 5.5-year follow-up period?. ### Response: LDL-C levels ≥100 mg/dL (≥2.6 mmol/L).


Instruction: What do other medical interventions that lower LDL-C levels via increased expression of LDL receptors reduce?

Output: ASCVD risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do other medical interventions that lower LDL-C levels via increased expression of LDL receptors reduce?. ### Response: ASCVD risk.


Instruction: How does increased expression of LDL receptors reduce ASCVD risk?

Output: other medical interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does increased expression of LDL receptors reduce ASCVD risk?. ### Response: other medical interventions.


Instruction: What may be considered after a clinician-patient discussion of the net benefits versus the cost of such therapy?

Output: treatment with a PCSK9 inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered after a clinician-patient discussion of the net benefits versus the cost of such therapy?. ### Response: treatment with a PCSK9 inhibitor.


Instruction: What is the cost of LDL-C-lowering therapy?

Output: 1.7 to 4.8 mmol/L

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cost of LDL-C-lowering therapy?. ### Response: 1.7 to 4.8 mmol/L.


Instruction: What is a patient with a genetic mutation associated with FH most likely to achieve the greatest benefit from?

Output: evidence-based LDL-C–lowering therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a patient with a genetic mutation associated with FH most likely to achieve the greatest benefit from?. ### Response: evidence-based LDL-C–lowering therapy.


Instruction: What is a baseline LDL-C level?

Output: ≥220 mg/dL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a baseline LDL-C level?. ### Response: ≥220 mg/dL.


Instruction: What is an on-treatment level of a PCSK9 inhibitor?

Output: ≥130 mg/dL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an on-treatment level of a PCSK9 inhibitor?. ### Response: ≥130 mg/dL.


Instruction: Patients who have maximally tolerated statin and ezetimibe therapy may be considered for treatment with what?

Output: PCSK9 inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients who have maximally tolerated statin and ezetimibe therapy may be considered for treatment with what?. ### Response: PCSK9 inhibitor.


Instruction: What is the cost-effectiveness of PCSK9 inhibitors for primary prevention among patients with LDL-C levels >190 mg/dL or with FH?

Output: has not been evaluated extensively

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cost-effectiveness of PCSK9 inhibitors for primary prevention among patients with LDL-C levels >190 mg/dL or with FH?. ### Response: has not been evaluated extensively.


Instruction: What has not been evaluated extensively?

Output: The cost-effectiveness of PCSK9 inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has not been evaluated extensively?. ### Response: The cost-effectiveness of PCSK9 inhibitors.


Instruction: How many published cost-effectiveness models for pri-mary prevention report very different results?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many published cost-effectiveness models for pri-mary prevention report very different results?. ### Response: 2.


Instruction: How much does one suggest an incremental cost effectiveness ratio per patient?

Output: $503 000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much does one suggest an incremental cost effectiveness ratio per patient?. ### Response: $503 000.


Instruction: What is the incremental cost-effectiveness ratio for PCSK9 inhibitors?

Output: $503 000 per QALY added

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the incremental cost-effectiveness ratio for PCSK9 inhibitors?. ### Response: $503 000 per QALY added.


Instruction: How much does one report per QALY added?

Output: $75 000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much does one report per QALY added?. ### Response: $75 000.


Instruction: What does the lack of consistent evidence mean about PCSK inhibitors in patients with hypercholesterolemia?

Output: uncertain value

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the lack of consistent evidence mean about PCSK inhibitors in patients with hypercholesterolemia?. ### Response: uncertain value.


Instruction: What type of hypercholesterolemia are patients with ASCVD at risk for?

Output: severe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of hypercholesterolemia are patients with ASCVD at risk for?. ### Response: severe.


Instruction: What are the Online Data Supplements 11 and 12 summarized in?

Output: Recommendations for Patients With Diabetes MellitusReferenced studies that support recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Online Data Supplements 11 and 12 summarized in?. ### Response: Recommendations for Patients With Diabetes MellitusReferenced studies that support recommendations.


Instruction: In adults 40 to 75 years of age with diabetes mellitus, regardless of estimated 10-year risk, what are the recommendations?

Output: moderate-intensity statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In adults 40 to 75 years of age with diabetes mellitus, regardless of estimated 10-year risk, what are the recommendations?. ### Response: moderate-intensity statin therapy.


Instruction: What type of statin therapy is indicated for adults with diabetes mellitus?

Output: moderate-intensity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of statin therapy is indicated for adults with diabetes mellitus?. ### Response: moderate-intensity.


Instruction: What is the LDL-C level of adults 40 to 75 years of age?

Output: 70 to 189 mg/dL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the LDL-C level of adults 40 to 75 years of age?. ### Response: 70 to 189 mg/dL.


Instruction: How long is it reasonable to assess the 10-year risk of a first ASCVD event?

Output: 5.5-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is it reasonable to assess the 10-year risk of a first ASCVD event?. ### Response: 5.5-year.


Instruction: What can race and sex-specific PCE help stratify?

Output: ASCVD risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can race and sex-specific PCE help stratify?. ### Response: ASCVD risk.


Instruction: What was the name of the TIMI 48 AF trials?

Output: edoxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the TIMI 48 AF trials?. ### Response: edoxaban.


Instruction: How many patients had mitral or aortic bioprosthet-ic valve implants?

Output: small numbers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had mitral or aortic bioprosthet-ic valve implants?. ### Response: small numbers.


Instruction: What did the findings suggest about apixaban?

Output: significantly lower rates of bleeding and death from cardiovascular causes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the findings suggest about apixaban?. ### Response: significantly lower rates of bleeding and death from cardiovascular causes.


Instruction: Warfarin in patients with AF and remote bioprosthetic valve implantation is what?

Output: equitable alternatives

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Warfarin in patients with AF and remote bioprosthetic valve implantation is what?. ### Response: equitable alternatives.


Instruction: Short-term anticoagulation of what is standard practice?

Output: bioprosthetic valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Short-term anticoagulation of what is standard practice?. ### Response: bioprosthetic valves.


Instruction: What is needed before the routine long-term use of the CHA2DS2-VASc score can be recom-mended in AF patients?

Output: further study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed before the routine long-term use of the CHA2DS2-VASc score can be recom-mended in AF patients?. ### Response: further study.


Instruction: What is the INR of a mechanical aortic valve replacement?

Output: 1.5 to 2.0

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the INR of a mechanical aortic valve replacement?. ### Response: 1.5 to 2.0.


Instruction: How long after implantation is the recommended INR?

Output: 3 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after implantation is the recommended INR?. ### Response: 3 months.


Instruction: What is low-dose aspirin based on?

Output: a limited clinical trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is low-dose aspirin based on?. ### Response: a limited clinical trial.


Instruction: What is the name of the approved mechanical valve prosthesis?

Output: On-X

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the approved mechanical valve prosthesis?. ### Response: On-X.


Instruction: How many NOACs have FDA approval for use?

Output: 4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many NOACs have FDA approval for use?. ### Response: 4.


Instruction: What are the 4 NOACs with FDA approval for use in patients with AF defined by?

Output: renal function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the 4 NOACs with FDA approval for use in patients with AF defined by?. ### Response: renal function.


Instruction: What does the Cockcroft-Gault equation use to define dosing?

Output: renal function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Cockcroft-Gault equation use to define dosing?. ### Response: renal function.


Instruction: How long does Apixaban have to be to be approved for use?

Output: age ≥80 years or weight ≤60 kg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does Apixaban have to be to be approved for use?. ### Response: age ≥80 years or weight ≤60 kg.


Instruction: When is Edoxaban not approved?

Output: patients with poor renal function (CrCl <30 mL/min) or upper-range renal function (CrCl >95 mL/min).

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is Edoxaban not approved?. ### Response: patients with poor renal function (CrCl <30 mL/min) or upper-range renal function (CrCl >95 mL/min)..


Instruction: What is not approved for use in patients with poor renal function or upper-range renal function?

Output: Edoxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not approved for use in patients with poor renal function or upper-range renal function?. ### Response: Edoxaban.


Instruction: What should be regularly monitored and CrCl calculated?

Output: Renal function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be regularly monitored and CrCl calculated?. ### Response: Renal function.


Instruction: What should be made according to FDA dosing guidelines?

Output: dose adjustments

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be made according to FDA dosing guidelines?. ### Response: dose adjustments.


Instruction: What should occasionally be monitored for the factor Xa inhibitors?

Output: hepatic function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should occasionally be monitored for the factor Xa inhibitors?. ### Response: hepatic function.


Instruction: NOACs are not recommended for use in patients with severe what?

Output: hepatic dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: NOACs are not recommended for use in patients with severe what?. ### Response: hepatic dysfunction.


Instruction: What was the name of the large randomized prospective AF trial?

Output: ENGAGE AF-TIMI 48

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the large randomized prospective AF trial?. ### Response: ENGAGE AF-TIMI 48.


Instruction: What was edoxaban associated with significantly lower rates of bleeding and death?

Output: cardiovascular causes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was edoxaban associated with significantly lower rates of bleeding and death?. ### Response: cardiovascular causes.


Instruction: What was associated with significantly lower rates of bleeding and death from cardiovascular causes?

Output: Edoxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with significantly lower rates of bleeding and death from cardiovascular causes?. ### Response: Edoxaban.


Instruction: What contributes to the increased risk of stroke in patients with AF as expressed in the CHA2DS2-VASc score?

Output: Many risk factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What contributes to the increased risk of stroke in patients with AF as expressed in the CHA2DS2-VASc score?. ### Response: Many risk factors.


Instruction: What has been assessed in many stud-ies?

Output: female sex

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been assessed in many stud-ies?. ### Response: female sex.


Instruction: Most studies support the finding that females Downloaded from http://ahajournals.org by on what date?

Output: April 23, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Most studies support the finding that females Downloaded from http://ahajournals.org by on what date?. ### Response: April 23, 2023.


Instruction: What is NICE 2018?

Output: All rights reserved

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE 2018?. ### Response: All rights reserved.


Instruction: What are the Outcomes No of Participants (studies)?

Output: Quality of the evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Outcomes No of Participants (studies)?. ### Response: Quality of the evidence.


Instruction: What is the GRADE of the evidence?

Output: Quality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the GRADE of the evidence?. ### Response: Quality.


Instruction: Anticipated absolute effects Risk with primary care Risk difference with MDT pharm (95% CI) (1 study) 12 months VERY LOWa, b due to risk of bias, what is the imprecision ratio?

Output: 0.51

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Anticipated absolute effects Risk with primary care Risk difference with MDT pharm (95% CI) (1 study) 12 months VERY LOWa, b due to risk of bias, what is the imprecision ratio?. ### Response: 0.51.


Instruction: What is the imprecision ratio?

Output: 0.51

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the imprecision ratio?. ### Response: 0.51.


Instruction: How many deaths were there in one study?

Output: 83

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many deaths were there in one study?. ### Response: 83.


Instruction: What was the risk of bias?

Output: the majority of the evidence was at high risk of bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk of bias?. ### Response: the majority of the evidence was at high risk of bias.


Instruction: Why was the death rate so low?

Output: risk of bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the death rate so low?. ### Response: risk of bias.


Instruction: How many fewer people live in Minnesota LWHFQ?

Output: 67

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many fewer people live in Minnesota LWHFQ?. ### Response: 67.


Instruction: What is the scale from: 0 to 105?

Output: Quality of life  Minnesota LWHFQ, lower=better

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the scale from: 0 to 105?. ### Response: Quality of life  Minnesota LWHFQ, lower=better.


Instruction: How many studies were conducted in Minnesota?

Output: 23

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were conducted in Minnesota?. ### Response: 23.


Instruction: Why was the risk of death a factor in the study?

Output: risk of bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the risk of death a factor in the study?. ### Response: risk of bias.


Instruction: What was the mean MLWHFQ final score in the control groups?

Output: 19.1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean MLWHFQ final score in the control groups?. ### Response: 19.1.


Instruction: The mean quality of life in the intervention groups was what?

Output: 6.40 lower

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The mean quality of life in the intervention groups was what?. ### Response: 6.40 lower.


Instruction: What is the risk of bias in Self-report 49 (1 study) 12 months  LOWa due to?

Output: Taking prescribed medication

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of bias in Self-report 49 (1 study) 12 months  LOWa due to?. ### Response: Taking prescribed medication.


Instruction: How many more per 1 000 (from 67 fewer to 48 more per 1000)?

Output: 48

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many more per 1 000 (from 67 fewer to 48 more per 1000)?. ### Response: 48.


Instruction: How many more people took prescribed medication?

Output: 172

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many more people took prescribed medication?. ### Response: 172.


Instruction: How many studies were conducted?

Output: 23

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were conducted?. ### Response: 23.


Instruction: Why was the RR of the study VERY LOW?

Output: risk of bias, imprecision

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the RR of the study VERY LOW?. ### Response: risk of bias, imprecision.


Instruction: How many more per 10 00?

Output: 468

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many more per 10 00?. ### Response: 468.


Instruction: How many increments were downgraded if the majority of the evidence was at high risk of bias?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many increments were downgraded if the majority of the evidence was at high risk of bias?. ### Response: 1.


Instruction: How many increments were downgraded if the majority of the evidence was at very high risk of bias?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many increments were downgraded if the majority of the evidence was at very high risk of bias?. ### Response: 1.


Instruction: How much increment as confidence interval crosses one MID or two incréments as confident interval crosses both MID?

Output: one increment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much increment as confidence interval crosses one MID or two incréments as confident interval crosses both MID?. ### Response: one increment.


Instruction: What is low risk, Long, Case -management?

Output: 9.2.3.3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is low risk, Long, Case -management?. ### Response: 9.2.3.3.


Instruction: What is the consensus panel guide to comprehensive risk reduction for adult patients without coronary or other atherosclerotic vascular diseases?

Output: AHA guidelines for primary prevention of cardiovascular disease and stroke: 2002 update

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the consensus panel guide to comprehensive risk reduction for adult patients without coronary or other atherosclerotic vascular diseases?. ### Response: AHA guidelines for primary prevention of cardiovascular disease and stroke: 2002 update.


Instruction: What is Bibbins-Domingo K's profession?

Output: US Preventive Services Task Force

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Bibbins-Domingo K's profession?. ### Response: US Preventive Services Task Force.


Instruction: What is the US Preventive Services Task Force Recommendation Statement for?

Output: primary prevention of cardiovascular disease and colorec-tal cancer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the US Preventive Services Task Force Recommendation Statement for?. ### Response: primary prevention of cardiovascular disease and colorec-tal cancer.


Instruction: What is a primary prevention of cardiovascular disease and colorec-tal cancer?

Output: Aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a primary prevention of cardiovascular disease and colorec-tal cancer?. ### Response: Aspirin.


Instruction: When was the Ann Intern Med164:836-45?

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Ann Intern Med164:836-45?. ### Response: 2016.


Instruction: What is the name of the study using aspirin to reduce risk of initial vascular events in patients at moderate risk of cardiovascular disease?

Output: ARRIVE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study using aspirin to reduce risk of initial vascular events in patients at moderate risk of cardiovascular disease?. ### Response: ARRIVE.


Instruction: What is ARRIVE?

Output: a randomised, double-blind, pla-cebo-controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ARRIVE?. ### Response: a randomised, double-blind, pla-cebo-controlled trial.


Instruction: At moderate risk of cardiovascular disease (ARRIVE): a randomised, double-blind, pla-cebo-controlled trial?

Output: Use of aspirin to reduce risk of initial vascular events in patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: At moderate risk of cardiovascular disease (ARRIVE): a randomised, double-blind, pla-cebo-controlled trial?. ### Response: Use of aspirin to reduce risk of initial vascular events in patients.


Instruction: In what year did the Lancet publish a report on ARRIVE?

Output: 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did the Lancet publish a report on ARRIVE?. ### Response: 2018.


Instruction: What is the scientific state-ment of the American Heart Association?

Output: Aspirin for primary pre-vention of cardiovascular events in people with diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the scientific state-ment of the American Heart Association?. ### Response: Aspirin for primary pre-vention of cardiovascular events in people with diabetes.


Instruction: What is a scientific statement of the American Heart Association?

Output: Value of primordial and primary prevention for cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a scientific statement of the American Heart Association?. ### Response: Value of primordial and primary prevention for cardiovascular disease.


Instruction: What is an expert consen-sus document of?

Output: American College of Cardiology Foundation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an expert consen-sus document of?. ### Response: American College of Cardiology Foundation.


Instruction: Which journal published a position paper on aspirin therapy in pri-mary cardiovascular disease prevention?

Output: European Society of Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which journal published a position paper on aspirin therapy in pri-mary cardiovascular disease prevention?. ### Response: European Society of Cardiology.


Instruction: What is a position paper of the European Society of Cardiology working group on thrombosis?

Output: Aspirin therapy in pri-mary cardiovascular disease prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a position paper of the European Society of Cardiology working group on thrombosis?. ### Response: Aspirin therapy in pri-mary cardiovascular disease prevention.


Instruction: When did the J Am Coll Cardiol. 2014:64:319–27?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the J Am Coll Cardiol. 2014:64:319–27?. ### Response: 2014.


Instruction: What is Aspirin for primary prevention of atherosclerotic cardiovascular disease?

Output: advances in diagnosis and treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Aspirin for primary prevention of atherosclerotic cardiovascular disease?. ### Response: advances in diagnosis and treatment.


Instruction: What is used to guide aspirin utilization for primary preven-tion?

Output: coronary artery calcium testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used to guide aspirin utilization for primary preven-tion?. ### Response: coronary artery calcium testing.


Instruction: What is the name of the multi-ethnic study of atherosclerosis?

Output: Miedema MD, Duprez DA, Misialek JR, et al. Use of coronary artery calcium testing to guide aspirin utilization for primary preven-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multi-ethnic study of atherosclerosis?. ### Response: Miedema MD, Duprez DA, Misialek JR, et al. Use of coronary artery calcium testing to guide aspirin utilization for primary preven-tion.


Instruction: When did Circ Cardiovasc Qual Outcomes publish?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circ Cardiovasc Qual Outcomes publish?. ### Response: 2014.


Instruction: What are the risks of vascular events and cancer according to bodyweight and dose?

Output: Effects of aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the risks of vascular events and cancer according to bodyweight and dose?. ### Response: Effects of aspirin.


Instruction: What is the name of the study that examined individual patient data from randomised trials?

Output: Lancet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined individual patient data from randomised trials?. ### Response: Lancet.


Instruction: When should aspirin be used for primary prevention?

Output: post-statin Era

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When should aspirin be used for primary prevention?. ### Response: post-statin Era.


Instruction: What is the post-statin era?

Output: primary prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the post-statin era?. ### Response: primary prevention.


Instruction: What are the costs and value considerations?

Output: S5-1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the costs and value considerations?. ### Response: S5-1.


Instruction: Who has a policy state-ment for primordial and primary prevention for cardiovascular disease?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who has a policy state-ment for primordial and primary prevention for cardiovascular disease?. ### Response: American Heart Association.


Instruction: What is the name of the Task Force on Performance Measures and Practice Guidelines?

Output: American College of Cardiology/American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Performance Measures and Practice Guidelines?. ### Response: American College of Cardiology/American Heart Association.


Instruction: What is the name of the book published by NICE 2018?

Output: Chronic Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the book published by NICE 2018?. ### Response: Chronic Heart Failure.


Instruction: What was the estimated cost of a QALY intervention?

Output: £20,000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the estimated cost of a QALY intervention?. ### Response: £20,000.


Instruction: What was the estimated cost per QALY gained?

Output: £20,000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the estimated cost per QALY gained?. ### Response: £20,000.


Instruction: What section of the relevant chapter discusses the reasons for the decision?

Output: ‘Recommendations and link to evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What section of the relevant chapter discusses the reasons for the decision?. ### Response: ‘Recommendations and link to evidence.


Instruction: What factors are set out in ‘Social value judgements: principles for the development of NICE guidance’?

Output: balance of benefits, harms and costs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What factors are set out in ‘Social value judgements: principles for the development of NICE guidance’?. ### Response: balance of benefits, harms and costs.


Instruction: When QALYs or life years gained are not used in the analysis, results are difficult to interpret?

Output: unless one strategy dominates the others with respect to every relevant health outcome and cost

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When QALYs or life years gained are not used in the analysis, results are difficult to interpret?. ### Response: unless one strategy dominates the others with respect to every relevant health outcome and cost.


Instruction: What is difficult to interpret unless one strategy dominates the others?

Output: When QALYs or life years gained

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is difficult to interpret unless one strategy dominates the others?. ### Response: When QALYs or life years gained.


Instruction: What did the committee make in the absence of health economic evidence?

Output: a qualitative judgement about cost  effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee make in the absence of health economic evidence?. ### Response: a qualitative judgement about cost  effectiveness.


Instruction: What was not prioritised?

Output: a new analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not prioritised?. ### Response: a new analysis.


Instruction: What did the committee make a qualitative judgement about?

Output: cost  effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee make a qualitative judgement about?. ### Response: cost  effectiveness.


Instruction: The committee considered expected differences in resource use between options and what?

Output: relevant UK NHS  unit costs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committee considered expected differences in resource use between options and what?. ### Response: relevant UK NHS  unit costs.


Instruction: What are the UK NHS costs reported in the guideline?

Output: those that were presented to the committee  and were correct at the time recommendations were drafted

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the UK NHS costs reported in the guideline?. ### Response: those that were presented to the committee  and were correct at the time recommendations were drafted.


Instruction: What may have changed subsequently before the time of publication?

Output: UK NHS costs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may have changed subsequently before the time of publication?. ### Response: UK NHS costs.


Instruction: What does the committee have no reason to believe has changed substantially?

Output: UK NHS costs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the committee have no reason to believe has changed substantially?. ### Response: UK NHS costs.


Instruction: What did the committee receive during the guideline development process?

Output: Evidence tables of the cl inical and health economic evidence reviewed from the literature

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee receive during the guideline development process?. ### Response: Evidence tables of the cl inical and health economic evidence reviewed from the literature.


Instruction: Where are all evidence tables located?

Output: appendices  F and G

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are all evidence tables located?. ### Response: appendices  F and G.


Instruction: Where are summaries of clinical and health economic evidence and quality?

Output: chapters  5-10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are summaries of clinical and health economic evidence and quality?. ### Response: chapters  5-10.


Instruction: What are presented in chapters 5-10?

Output: Summaries of clinical and health economic evidence and quality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are presented in chapters 5-10?. ### Response: Summaries of clinical and health economic evidence and quality.


Instruction: What was the purpose of the cost -effectiveness analyses?

Output: for the guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the purpose of the cost -effectiveness analyses?. ### Response: for the guideline.


Instruction: What did the committee take into account in drafting recommendations?

Output: the balance of benefits, harms and costs between different courses of action

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee take into account in drafting recommendations?. ### Response: the balance of benefits, harms and costs between different courses of action.


Instruction: How was the balance of benefits, harms and costs calculated?

Output: informally

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the balance of benefits, harms and costs calculated?. ### Response: informally.


Instruction: Informally, what was the net clinical benefit over harm considered?

Output: c linical effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Informally, what was the net clinical benefit over harm considered?. ### Response: c linical effectiveness.


Instruction: What was the focus of the clinical effectiveness?

Output: critical outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the focus of the clinical effectiveness?. ### Response: critical outcomes.


Instruction: When did the committee take into account the clinical benefits and harms when one intervention was compared with another?

Output: informally

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the committee take into account the clinical benefits and harms when one intervention was compared with another?. ### Response: informally.


Instruction: What was the committee's values and preferences?

Output: outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the committee's values and preferences?. ### Response: outcomes.


Instruction: What are the committee's values and preferences?

Output: outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the committee's values and preferences?. ### Response: outcomes.


Instruction: What is the confidence the committee had in the evidence?

Output: evidence quality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the confidence the committee had in the evidence?. ### Response: evidence quality.


Instruction: The committee assessed whether the net clinical benefit justified any differences in what?

Output: costs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committee assessed whether the net clinical benefit justified any differences in what?. ### Response: costs.


Instruction: Who published Guidelines for Prevention of Stroke in Women 1563CI, 1.03-1.58?

Output: Bushnell et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published Guidelines for Prevention of Stroke in Women 1563CI, 1.03-1.58?. ### Response: Bushnell et al.


Instruction: What was the P for trend=0.02?

Output: Guidelines for Prevention of Stroke in Women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the P for trend=0.02?. ### Response: Guidelines for Prevention of Stroke in Women.


Instruction: There was no trend for increased stroke based on years since what?

Output: menopause

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There was no trend for increased stroke based on years since what?. ### Response: menopause.


Instruction: The Estonian trial of HT confirmed the findings of what study?

Output: WHI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The Estonian trial of HT confirmed the findings of what study?. ### Response: WHI.


Instruction: What is the Kronos Early Estrogen Prevention Study?

Output: KEEPS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Kronos Early Estrogen Prevention Study?. ### Response: KEEPS.


Instruction: How old are women taking HT257?

Output: 50 to 64

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old are women taking HT257?. ### Response: 50 to 64.


Instruction: What is KEEPS?

Output: Kronos Early Estrogen Prevention Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is KEEPS?. ### Response: Kronos Early Estrogen Prevention Study.


Instruction: How many months after their final menstrual period were women randomized to estrogen replacement in low doses?

Output: 36

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many months after their final menstrual period were women randomized to estrogen replacement in low doses?. ### Response: 36.


Instruction: How many days each month did women receive cyclic oral, micronized progesterone 200 mg?

Output: 12

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many days each month did women receive cyclic oral, micronized progesterone 200 mg?. ### Response: 12.


Instruction: What is the primary dose of estrogen replacement?

Output: Transdermal estradiol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary dose of estrogen replacement?. ### Response: Transdermal estradiol.


Instruction: How many days a month does progesterone last?

Output: 12

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many days a month does progesterone last?. ### Response: 12.


Instruction: What are the primary outcomes of this study?

Output: progres-sion of subclinical atherosclerosis as measured by carotid intima-media thickness and coronary calcium scores

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the primary outcomes of this study?. ### Response: progres-sion of subclinical atherosclerosis as measured by carotid intima-media thickness and coronary calcium scores.


Instruction: How is subclinical atherosclerosis measured?

Output: carotid intima-media thickness and coronary calcium scores

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is subclinical atherosclerosis measured?. ### Response: carotid intima-media thickness and coronary calcium scores.


Instruction: When was the meeting of the North American Menopause Society held?

Output: October 3, 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the meeting of the North American Menopause Society held?. ### Response: October 3, 2012.


Instruction: What is the name of the organization that presented the initial results of the HT study?

Output: North American Menopause Society

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that presented the initial results of the HT study?. ### Response: North American Menopause Society.


Instruction: What is the name of the open-label Danish Osteoporosis Prevention Study?

Output: DOPS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the open-label Danish Osteoporosis Prevention Study?. ### Response: DOPS.


Instruction: How many randomized trials were conducted in Denmark?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many randomized trials were conducted in Denmark?. ### Response: 1.


Instruction: What was the duration of use for HT in this subset of women?

Output: 50 to 64 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the duration of use for HT in this subset of women?. ### Response: 50 to 64 years of age.


Instruction: What was a designated end point?

Output: Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a designated end point?. ### Response: Stroke.


Instruction: How many women were randomly allocated to the study?

Output: 502

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many women were randomly allocated to the study?. ### Response: 502.


Instruction: What was the mean time since menopause?

Output: 0.6 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean time since menopause?. ### Response: 0.6 years.


Instruction: How many women were randomly allocated to receive HT and 504 to receive no treatment?

Output: 502

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many women were randomly allocated to receive HT and 504 to receive no treatment?. ### Response: 502.


Instruction: What was important about the open-label design of the study?

Output: patients in the control arm did not receive placebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was important about the open-label design of the study?. ### Response: patients in the control arm did not receive placebo.


Instruction: The patients in the control arm did not receive what?

Output: placebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The patients in the control arm did not receive what?. ### Response: placebo.


Instruction: How long did the trial last?

Output: 11 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the trial last?. ### Response: 11 years.


Instruction: Why was the trial stopped after 11 years?

Output: secondary to concerns of potentially harmful effects of HT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the trial stopped after 11 years?. ### Response: secondary to concerns of potentially harmful effects of HT.


Instruction: How long was the observational cohort followed?

Output: 5 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the observational cohort followed?. ### Response: 5 years.


Instruction: How long did the observational cohort last?

Output: 5 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the observational cohort last?. ### Response: 5 years.


Instruction: There was no increase in stroke, VTE, or breast cancer in treated women?

Output: observational cohort

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There was no increase in stroke, VTE, or breast cancer in treated women?. ### Response: observational cohort.


Instruction: What did younger women significantly reduce the risk of?

Output: combined end point of mortality, MI, or heart fail-ure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did younger women significantly reduce the risk of?. ### Response: combined end point of mortality, MI, or heart fail-ure.


Instruction: What is MI?

Output: heart fail-ure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is MI?. ### Response: heart fail-ure.


Instruction: Stroke rates did not differ between groups.

Output: There was, however, no trend for increased stroke based on years since menopause

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Stroke rates did not differ between groups.. ### Response: There was, however, no trend for increased stroke based on years since menopause.


Instruction: What may represent a safer alterna-tive than oral estrogens?

Output: Transdermal estradiol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may represent a safer alterna-tive than oral estrogens?. ### Response: Transdermal estradiol.


Instruction: How many stroke cases were included in a nested case-control study?

Output: 15 710

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many stroke cases were included in a nested case-control study?. ### Response: 15 710.


Instruction: Who is the Board of Trustees of the Guidelines InternationalNetwork?

Output: Qaseem A, Forland F, Macbeth F, Ollenschl ¨ager G, Phillips S, van der Wees P

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Board of Trustees of the Guidelines InternationalNetwork?. ### Response: Qaseem A, Forland F, Macbeth F, Ollenschl ¨ager G, Phillips S, van der Wees P.


Instruction: What is the goal of the guidelines international network?

Output: inter national standards for clinical practice guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the goal of the guidelines international network?. ### Response: inter national standards for clinical practice guidelines.


Instruction: When was the Ann Intern Med 156(7) published?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Ann Intern Med 156(7) published?. ### Response: 2012.


Instruction: Who is the Board of Trustees of the Guidelines International Network?

Output: Qaseem A, Forland F, Macbeth F, Ollenschl ¨ager G, Phillips S, van der Wees P

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Board of Trustees of the Guidelines International Network?. ### Response: Qaseem A, Forland F, Macbeth F, Ollenschl ¨ager G, Phillips S, van der Wees P.


Instruction: What is the principle for disclosure of interests and management of conflicts in guidelines?

Output: Guidelines International Network

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the principle for disclosure of interests and management of conflicts in guidelines?. ### Response: Guidelines International Network.


Instruction: What is a systematic and transparent approach to making well informed healthcare choices?

Output: GRADE Evidence to Decision (EtD) frameworks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a systematic and transparent approach to making well informed healthcare choices?. ### Response: GRADE Evidence to Decision (EtD) frameworks.


Instruction: What are GRADE Evidence to Decision frameworks?

Output: tests inclinical practice and public health

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are GRADE Evidence to Decision frameworks?. ### Response: tests inclinical practice and public health.


Instruction: GRADE Evidence to Decision frameworks are a systematic and transparent approach to making what?

Output: well informed healthcare choices

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: GRADE Evidence to Decision frameworks are a systematic and transparent approach to making what?. ### Response: well informed healthcare choices.


Instruction: Atkins D, Eccles M, Flottorp S, et al; GRADE Working Group. Systems for grading the quality of evidence and the strength of recommendations.

Output: 2016;353:i2016.8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atkins D, Eccles M, Flottorp S, et al; GRADE Working Group. Systems for grading the quality of evidence and the strength of recommendations.. ### Response: 2016;353:i2016.8.


Instruction: What is one of the strengths of recommendations?

Output: evidence to decision frameworks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the strengths of recommendations?. ### Response: evidence to decision frameworks.


Instruction: What is another of the strength of recommendations that can be made?

Output: GRADE Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another of the strength of recommendations that can be made?. ### Response: GRADE Guidelines.


Instruction: What is an emerging consensus on rating quality of evidence and strength ofrecommendations?

Output: GRADE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an emerging consensus on rating quality of evidence and strength ofrecommendations?. ### Response: GRADE.


Instruction: What is a GRADE Working Group?

Output: Systems for grading the quality of evidence and the strength of recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a GRADE Working Group?. ### Response: Systems for grading the quality of evidence and the strength of recommendations.


Instruction: When did the BMJ issue 336(7650):924-926?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the BMJ issue 336(7650):924-926?. ### Response: 2008.


Instruction: What is the name of the GRADE Working Group?

Output: Sch ¨unemann HJ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the GRADE Working Group?. ### Response: Sch ¨unemann HJ.


Instruction: What is a GRADE Guidelines?

Output: 1. Introdu ction-GRADE evidence profiles and summary of findings tables

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a GRADE Guidelines?. ### Response: 1. Introdu ction-GRADE evidence profiles and summary of findings tables.


Instruction: What is the name of the 9th ed of AmericanCollege of Chest Physicians Evidence-Based Clinical Practice Guidelines?

Output: Parenteral anticoagulants: Antithrombotic Therapy and Prevention of Thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 9th ed of AmericanCollege of Chest Physicians Evidence-Based Clinical Practice Guidelines?. ### Response: Parenteral anticoagulants: Antithrombotic Therapy and Prevention of Thrombosis.


Instruction: What are the names of the tests used in public health and inclinical practice?

Output: GRADE Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the tests used in public health and inclinical practice?. ### Response: GRADE Guidelines.


Instruction: What is the name of the 9th edition of Antithrombotic Therapy and Prevention of Thrombosis?

Output: American College of Chest Physici ans Evidence-Based Clinical Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 9th edition of Antithrombotic Therapy and Prevention of Thrombosis?. ### Response: American College of Chest Physici ans Evidence-Based Clinical Practice Guidelines.


Instruction: What was the title of the 8th ed. of the American College of ChestPhysicians Evidence-Based Clinical Practice Guidelines?

Output: GRADE Working Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the title of the 8th ed. of the American College of ChestPhysicians Evidence-Based Clinical Practice Guidelines?. ### Response: GRADE Working Group.


Instruction: What is the name of the ASH 2018 VTE GUIDELINES: ANTICOAGULATION MANAGEMENT 3283Downloaded from http://ashpublications.org/bloodadvances/article-pdf/2/22/3257/1630010/advaces024893cg?

Output: NUMBER 22

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the ASH 2018 VTE GUIDELINES: ANTICOAGULATION MANAGEMENT 3283Downloaded from http://ashpublications.org/bloodadvances/article-pdf/2/22/3257/1630010/advaces024893cg?. ### Response: NUMBER 22.


Instruction: How many patients with stable coronary artery disease were treated with rosuvastatin pharmacoki-netics and pharmacogenetics in the 2018 Cholesterol Clinical Practice Guidelines?

Output: 13 054

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with stable coronary artery disease were treated with rosuvastatin pharmacoki-netics and pharmacogenetics in the 2018 Cholesterol Clinical Practice Guidelines?. ### Response: 13 054.


Instruction: What is Rosuvastatin pharmacokinetics and pharmacogenetics in white and Asian subjects residing in the same environment?

Output: pharmacoki-netics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Rosuvastatin pharmacokinetics and pharmacogenetics in white and Asian subjects residing in the same environment?. ### Response: pharmacoki-netics.


Instruction: What is Liao JK's title?

Output: Safety and efficacy of statins in Asians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Liao JK's title?. ### Response: Safety and efficacy of statins in Asians.


Instruction: What is the name of the study that evaluated statins in Asians?

Output: Liao JK

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated statins in Asians?. ### Response: Liao JK.


Instruction: What is another name for rosuvastatin?

Output: atorvastatin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for rosuvastatin?. ### Response: atorvastatin.


Instruction: How many patients were compared to atorvastatine in the STARSHIP trial?

Output: 768–73

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were compared to atorvastatine in the STARSHIP trial?. ### Response: 768–73.


Instruction: What is the name of the 2013 ACC/AHA guideline on the treatment of blood cholesterol?

Output: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2013 ACC/AHA guideline on the treatment of blood cholesterol?. ### Response: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.


Instruction: What are the effects of demographics, comorbidities, and body composition on the normal range?

Output: Creatine kinase in the US popula-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the effects of demographics, comorbidities, and body composition on the normal range?. ### Response: Creatine kinase in the US popula-tion.


Instruction: What is a risk factor for cardiovascular disease independent of plasma triglyceride level?

Output: high-density lipoprotein cholesterol level

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for cardiovascular disease independent of plasma triglyceride level?. ### Response: high-density lipoprotein cholesterol level.


Instruction: What is the 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce?

Output: ath-erosclerotic cardiovascular risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce?. ### Response: ath-erosclerotic cardiovascular risk.


Instruction: What is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level?

Output: Plasma triglyceride level

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level?. ### Response: Plasma triglyceride level.


Instruction: What is the meta-analysis of population-based prospective studies?

Output: Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the meta-analysis of population-based prospective studies?. ### Response: Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level.


Instruction: What causes myocardial infarction, ischemic heart disease, and death in men and women?

Output: Nonfasting triglycerides

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes myocardial infarction, ischemic heart disease, and death in men and women?. ### Response: Nonfasting triglycerides.


Instruction: What is a VOYAGER meta-anal-ysis of the impact of triglyc-erides?

Output: population-based prospective studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a VOYAGER meta-anal-ysis of the impact of triglyc-erides?. ### Response: population-based prospective studies.


Instruction: What is the name of the meta-anal-ysis of the impact of statin therapy on low-density lipoprotein cho-lesterol and triglyceride levels?

Output: VOYAGER

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-anal-ysis of the impact of statin therapy on low-density lipoprotein cho-lesterol and triglyceride levels?. ### Response: VOYAGER.


Instruction: What is one of the effects of lowering LDL cholesterol with statin?

Output: low risk of vascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the effects of lowering LDL cholesterol with statin?. ### Response: low risk of vascular disease.


Instruction: How many randomised trials were included in the meta-analysis?

Output: 27

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many randomised trials were included in the meta-analysis?. ### Response: 27.


Instruction: What is the average triglyceride level in a person with low risk of vascular disease?

Output: 500 mg/dL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the average triglyceride level in a person with low risk of vascular disease?. ### Response: 500 mg/dL.


Instruction: What is observed when follow-up triglyceride levels are less than 500 mg/dL?

Output: Clinical and eco-nomic benefits

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is observed when follow-up triglyceride levels are less than 500 mg/dL?. ### Response: Clinical and eco-nomic benefits.


Instruction: What is Simvastatin?

Output: rosuvastatin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Simvastatin?. ### Response: rosuvastatin.


Instruction: Who is a senior research sci-entist at Arbor Research Collaborativefor Health?

Output: Roberto Pecoits-Filho

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a senior research sci-entist at Arbor Research Collaborativefor Health?. ### Response: Roberto Pecoits-Filho.


Instruction: What is Roberto Pecoits-Filho's profession?

Output: MD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Roberto Pecoits-Filho's profession?. ### Response: MD.


Instruction: Where is the Ponti ficalCatholic University of Paraná located?

Output: Curi-tiba, Brazil

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the Ponti ficalCatholic University of Paraná located?. ### Response: Curi-tiba, Brazil.


Instruction: Where is Dr. Pecoits-Filho based?

Output: Curitiba, Brazil

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Dr. Pecoits-Filho based?. ### Response: Curitiba, Brazil.


Instruction: When was he the chief of the Department of Internal Medicine?

Output: between 2010 and2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was he the chief of the Department of Internal Medicine?. ### Response: between 2010 and2016.


Instruction: Where is he director of the residency program innephrology?

Output: Tufts MedicalCenter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is he director of the residency program innephrology?. ### Response: Tufts MedicalCenter.


Instruction: Where did Dr. Pecoits-Filho receive his medical degree?

Output: Curitiba, Brazil

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where did Dr. Pecoits-Filho receive his medical degree?. ### Response: Curitiba, Brazil.


Instruction: Where did he train in internal medicine and nephrology?

Output: Curitiba, Brazil

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where did he train in internal medicine and nephrology?. ### Response: Curitiba, Brazil.


Instruction: Where did he receive a fellowship in nephrology?

Output: Tufts MedicalCenter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where did he receive a fellowship in nephrology?. ### Response: Tufts MedicalCenter.