Instruction: What are symptoms higher in women than men?

Output: stroke warning signs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are symptoms higher in women than men?. ### Response: stroke warning signs.


Instruction: What is tissue-type plasminogen activator therapy for stroke called?

Output: 81–83 One study reported that although women were more likely than men to have heard of tissue-type plasminogen activator therapy for stroke, they were less likely to know that it must be administered within 3 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is tissue-type plasminogen activator therapy for stroke called?. ### Response: 81–83 One study reported that although women were more likely than men to have heard of tissue-type plasminogen activator therapy for stroke, they were less likely to know that it must be administered within 3 hours.


Instruction: Women are more likely than men to have heard of what?

Output: tissue-type plasminogen activator therapy for stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Women are more likely than men to have heard of what?. ### Response: tissue-type plasminogen activator therapy for stroke.


Instruction: How long did it take for a stroke to be administered?

Output: 3 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for a stroke to be administered?. ### Response: 3 hours.


Instruction: Who conducted the AHA's population-based surveys of women?

Output: AHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who conducted the AHA's population-based surveys of women?. ### Response: AHA.


Instruction: What type of women have a poor knowledge of CVD and stroke?

Output: minority

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of women have a poor knowledge of CVD and stroke?. ### Response: minority.


Instruction: What does epidemiology research mostly describe?

Output: IS events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does epidemiology research mostly describe?. ### Response: IS events.


Instruction: What is needed to understand sex differences for hemorrhagic stroke events?

Output: Additional research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed to understand sex differences for hemorrhagic stroke events?. ### Response: Additional research.


Instruction: Data are limited in terms of what?

Output: sex-, race-, and age-specific rates of stroke incidence, mortality, and case fatality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Data are limited in terms of what?. ### Response: sex-, race-, and age-specific rates of stroke incidence, mortality, and case fatality.


Instruction: What is an important gap because disease patterns and outcomes have been shown to vary by these characteristics?

Output: Data are limited in terms of sex-, race-, and age-specific rates of stroke incidence, mortality, and case fatality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an important gap because disease patterns and outcomes have been shown to vary by these characteristics?. ### Response: Data are limited in terms of sex-, race-, and age-specific rates of stroke incidence, mortality, and case fatality.


Instruction: Future studies should report data separately for men and women when examining sex differences in dis-ease rates?

Output: Most studies that have explored knowledge and awareness of stroke symptoms in either stroke patients or  at-risk populations have not compared results by sex

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Future studies should report data separately for men and women when examining sex differences in dis-ease rates?. ### Response: Most studies that have explored knowledge and awareness of stroke symptoms in either stroke patients or  at-risk populations have not compared results by sex.


Instruction: What should be reported by race/ethnicity for each stroke subtype?

Output: the incidence, mortal-ity, and case fatality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be reported by race/ethnicity for each stroke subtype?. ### Response: the incidence, mortal-ity, and case fatality.


Instruction: What are lower stroke event rates?

Output: women than men

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are lower stroke event rates?. ### Response: women than men.


Instruction: What are stroke event rates lower in women than men?

Output: 28-day case fatality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are stroke event rates lower in women than men?. ### Response: 28-day case fatality.


Instruction: What masks important differences by age?

Output: sex comparisons based on age-adjusted rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What masks important differences by age?. ### Response: sex comparisons based on age-adjusted rates.


Instruction: There is a higher lifetime risk of stroke in what gender?

Output: women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is a higher lifetime risk of stroke in what gender?. ### Response: women.


Instruction: In what gender is there a greater number of stroke deaths?

Output: women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what gender is there a greater number of stroke deaths?. ### Response: women.


Instruction: What is the most common modifiable risk factor for stroke in both men and women?

Output: Vascular Differences in Stroke Risk: Sex  and HypertensionHypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common modifiable risk factor for stroke in both men and women?. ### Response: Vascular Differences in Stroke Risk: Sex  and HypertensionHypertension.


Instruction: What has the highest population- attributable risk?

Output: Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has the highest population- attributable risk?. ### Response: Hypertension.


Instruction: What are some important sex differences in the prevalence, treatment, and pathophysiology of hypertension?

Output: Delay, Warning Signs, Risk Factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some important sex differences in the prevalence, treatment, and pathophysiology of hypertension?. ### Response: Delay, Warning Signs, Risk Factors.


Instruction: What should be highlighted to improve awareness and treatment of this risk factor in women?

Output: sex dif-ferences in the prevalence, treatment, and pathophysiology of hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be highlighted to improve awareness and treatment of this risk factor in women?. ### Response: sex dif-ferences in the prevalence, treatment, and pathophysiology of hypertension.


Instruction: What are some people who will need treatment with more thanoneantihypertensive drug to achieve BP control?

Output: blackpatients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some people who will need treatment with more thanoneantihypertensive drug to achieve BP control?. ### Response: blackpatients.


Instruction: What should be appliedwithcautiontothesepopula-tions?

Output: rec-ommendation6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be appliedwithcautiontothesepopula-tions?. ### Response: rec-ommendation6.


Instruction: For general black population, what should bedosedadequatetoachieversultssimilarto?

Output: Moderate Recommendation – Grade B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For general black population, what should bedosedadequatetoachieversultssimilarto?. ### Response: Moderate Recommendation – Grade B.


Instruction: What type of diuretic wasmore effective in improving cerebrovascular, heart failure, and combined cardiovascular outcomes compared to an ACEI in theblackpatientsubgroup?

Output: thiazide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diuretic wasmore effective in improving cerebrovascular, heart failure, and combined cardiovascular outcomes compared to an ACEI in theblackpatientsubgroup?. ### Response: thiazide.


Instruction: What was lesseffectivethanadiureticinpreventingheartfailureintheblacksubgroupofthistrial?

Output: CCB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was lesseffectivethanadiureticinpreventingheartfailureintheblacksubgroupofthistrial?. ### Response: CCB.


Instruction: What was less effective than adiureticinpreventingheartfailureintheblacksubgroupofthistrial?

Output: CCB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was less effective than adiureticinpreventingheartfailureintheblacksubgroupofthistrial?. ### Response: CCB.


Instruction: What did the panel recommend as first-linetherapy in black patients?

Output: CCB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the panel recommend as first-linetherapy in black patients?. ### Response: CCB.


Instruction: Why was a CCB recommended over an ACEI?

Output: there was a 51% higher rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was a CCB recommended over an ACEI?. ### Response: there was a 51% higher rate.


Instruction: How much higher was the rate of stroke in black people inALLHATwiththeuseofanACEIasinitialtherapycomparedwithuseofaCCB?

Output: 51%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much higher was the rate of stroke in black people inALLHATwiththeuseofanACEIasinitialtherapycomparedwithuseofaCCB?. ### Response: 51%.


Instruction: What was less effective in reducing BP in black individuals comparedwiththeACEI?

Output: TheACEI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was less effective in reducing BP in black individuals comparedwiththeACEI?. ### Response: TheACEI.


Instruction: What percentage of survivors survive in monitored intensive care units?

Output: >90%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of survivors survive in monitored intensive care units?. ### Response: >90%..


Instruction: What is the survival rate after the initial 2 minutes?

Output: ≤25%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the survival rate after the initial 2 minutes?. ### Response: ≤25%,.


Instruction: How much survival decreases rapidly after the initial 2 minutes from the onset of car -diac arrest?

Output: S6-33–S6-36

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much survival decreases rapidly after the initial 2 minutes from the onset of car -diac arrest?. ### Response: S6-33–S6-36.


Instruction: By 4 to 5 minutes, survival may be 25%, and by 10 minutes, it is what?

Output: 0%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: By 4 to 5 minutes, survival may be 25%, and by 10 minutes, it is what?. ### Response: 0%..


Instruction: Cardioversion and defibrillation for control of tachyarrhythmias are not related to what other activity?

Output: life support

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cardioversion and defibrillation for control of tachyarrhythmias are not related to what other activity?. ### Response: life support.


Instruction: What are cardioversion and defibrillation for control of?

Output: tachyarrhythmias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are cardioversion and defibrillation for control of?. ### Response: tachyarrhythmias.


Instruction: What have led to the generation of comprehensive protocols to guide responders?

Output: Advanced life support activities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have led to the generation of comprehensive protocols to guide responders?. ### Response: Advanced life support activities.


Instruction: These AHA documents cover the broad expanse of what?

Output: clinical circumstances and con-siderations of mechanisms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: These AHA documents cover the broad expanse of what?. ### Response: clinical circumstances and con-siderations of mechanisms.


Instruction: How many failed shocks and administration of epi-nephrine improved hospital admission rates?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many failed shocks and administration of epi-nephrine improved hospital admission rates?. ### Response: 3.


Instruction: What was not improved with placeboS6-6 or 1.5 mg/kg lido-caineS6-1,S6-4 in RCTs?

Output: survival to hospital discharge

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not improved with placeboS6-6 or 1.5 mg/kg lido-caineS6-1,S6-4 in RCTs?. ### Response: survival to hospital discharge.


Instruction: What was not improved with amiodarone or lidocaine?

Output: survival to hospital discharge and survival with favorable neurologic outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not improved with amiodarone or lidocaine?. ### Response: survival to hospital discharge and survival with favorable neurologic outcome.


Instruction: What was higher in the subset of patients with witnessed cardiac arrest due to initial shock-refractory VF or pulseless VT?

Output: survival to hospital discharge

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was higher in the subset of patients with witnessed cardiac arrest due to initial shock-refractory VF or pulseless VT?. ### Response: survival to hospital discharge.


Instruction: What has been associated with more shocks, more pharmacologic interventions, longer resuscitation times, and lower survival?

Output: procainamide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been associated with more shocks, more pharmacologic interventions, longer resuscitation times, and lower survival?. ### Response: procainamide.


Instruction: What causes loss of consciousness and leads to death?

Output: VA with hemodynamic instability

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes loss of consciousness and leads to death?. ### Response: VA with hemodynamic instability.


Instruction: What causes loss of consciousness and leads to death if untreated?

Output: VA with hemodynamic instability

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes loss of consciousness and leads to death if untreated?. ### Response: VA with hemodynamic instability.


Instruction: A short time to direct current car -dioversion is the major determinant of what?

Output: sur -vival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A short time to direct current car -dioversion is the major determinant of what?. ### Response: sur -vival.


Instruction: What is used until a perfusing rhythm is restored?

Output: CPR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used until a perfusing rhythm is restored?. ### Response: CPR.


Instruction: If defibrillation is unsuccessful in returning spontaneous circulation, responders follow what?

Output: advanced cardiovascular life support activities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: If defibrillation is unsuccessful in returning spontaneous circulation, responders follow what?. ### Response: advanced cardiovascular life support activities.


Instruction: What is associated with improved sur vival and better functional recovery?

Output: Quickly identifying and treating patients with out-of-hospital cardiac arrest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with improved sur vival and better functional recovery?. ### Response: Quickly identifying and treating patients with out-of-hospital cardiac arrest.


Instruction: What is not reli-ably predicted by clinical and electrocardiographic Recommendations for Management of Cardiac Arrest (Continued)?

Output: Coronary occlusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not reli-ably predicted by clinical and electrocardiographic Recommendations for Management of Cardiac Arrest (Continued)?. ### Response: Coronary occlusion.


Instruction: On what date were the recommendations downloaded from http://ahajournals.org?

Output: April 23, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On what date were the recommendations downloaded from http://ahajournals.org?. ### Response: April 23, 2023.


Instruction: Who wrote the 2019 Guidelines for Management of AIS e401?

Output: Powers et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote the 2019 Guidelines for Management of AIS e401?. ### Response: Powers et al.


Instruction: What is the name of the University of Iowa professor of medicine?

Output: Colin P. Derdeyn

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the University of Iowa professor of medicine?. ### Response: Colin P. Derdeyn.


Instruction: Who is the president of the American Heart Association?

Output: Karen L. Furie

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the president of the American Heart Association?. ### Response: Karen L. Furie.


Instruction: Who received compensation for expert witness work?

Output: Employer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who received compensation for expert witness work?. ### Response: Employer.


Instruction: What was the name of the clinical trial that was not funded by the employer?

Output: NeuroSpring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the clinical trial that was not funded by the employer?. ### Response: NeuroSpring.


Instruction: What is the University of Maryland School of Medicine?

Output: Maryland Health Care System

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the University of Maryland School of Medicine?. ### Response: Maryland Health Care System.


Instruction: Who is the Director of the Cedars-Sinai Medical Center?

Output: Patrick D. Lyden

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Director of the Cedars-Sinai Medical Center?. ### Response: Patrick D. Lyden.


Instruction: Who is the employer of St. Jude Medical?

Output: University of California

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the employer of St. Jude Medical?. ### Response: University of California.


Instruction: What is the name of the private law firm that holds stock holdings in various pharma companies?

Output: Lawrence R. Wechsler

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the private law firm that holds stock holdings in various pharma companies?. ### Response: Lawrence R. Wechsler.


Instruction: What is a managed investment portfolio?

Output: family

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a managed investment portfolio?. ### Response: family.


Instruction: What is the name of a speaker's bureau?

Output: Stryker Neurovascular

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of a speaker's bureau?. ### Response: Stryker Neurovascular.


Instruction: What type of conflicts of interest are reported on the Disclosure Questionnaire?

Output: actual or reasonably perceived

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of conflicts of interest are reported on the Disclosure Questionnaire?. ### Response: actual or reasonably perceived.


Instruction: What is a relationship considered to be if a person receives $10 000 or more during a 12-month period?

Output: significant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a relationship considered to be if a person receives $10 000 or more during a 12-month period?. ### Response: significant.


Instruction: How much of a person's gross income does he or she earn during a 12-month period?

Output: 5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of a person's gross income does he or she earn during a 12-month period?. ### Response: 5%.


Instruction: How much or more of the voting stock or share of an entity does the person own?

Output: 5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much or more of the voting stock or share of an entity does the person own?. ### Response: 5%.


Instruction: What is the percentage of the fair market value of the entity?

Output: $10 000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the percentage of the fair market value of the entity?. ### Response: $10 000.


Instruction: What is a relationship considered to be if it is less than "significant"?

Output: modest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a relationship considered to be if it is less than "significant"?. ### Response: modest.


Instruction: What is the definition of a "modest" relationship?

Output: less than “significant”

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the definition of a "modest" relationship?. ### Response: less than “significant”.


Instruction: Where can a reviewer's disclosure be found?

Output: the Disclosure Questionnaire

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can a reviewer's disclosure be found?. ### Response: the Disclosure Questionnaire.


Instruction: How many classes of antihypertensive agents are available to treat high BP?

Output: Numerous

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many classes of antihypertensive agents are available to treat high BP?. ### Response: Numerous.


Instruction: What should agents that have been shown to reduce clinical events be used preferentially?

Output: antihypertensive agents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should agents that have been shown to reduce clinical events be used preferentially?. ### Response: antihypertensive agents.


Instruction: Which pri-mary agents are used in the treatment of hypertension?

Output: thia-zide diuretics, ACE inhibitors, ARBs, and CCBsS8.1.4-8–S8.1.4-11

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which pri-mary agents are used in the treatment of hypertension?. ### Response: thia-zide diuretics, ACE inhibitors, ARBs, and CCBsS8.1.4-8–S8.1.4-11.


Instruction: What are some of the pri-mary agents used in the treatment of hypertension?

Output: thia-zide diuretics, ACE inhibitors, ARBs, and CCBsS8.1.4-8–S8.1.4-11

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the pri-mary agents used in the treatment of hypertension?. ### Response: thia-zide diuretics, ACE inhibitors, ARBs, and CCBsS8.1.4-8–S8.1.4-11.


Instruction: What are ACE inhibitors, ARBs, and CCBs?

Output: thia-zide diuretics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are ACE inhibitors, ARBs, and CCBs?. ### Response: thia-zide diuretics.


Instruction: What may relegate primary agents to use as sec-ondary agents?

Output: safety and tolerability

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may relegate primary agents to use as sec-ondary agents?. ### Response: safety and tolerability.


Instruction: There is inadequate evidence to support the initial use of beta blockers for hypertension in the absence of what?

Output: specific cardiovascular comorbidities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is inadequate evidence to support the initial use of beta blockers for hypertension in the absence of what?. ### Response: specific cardiovascular comorbidities.


Instruction: What are specific cardiovascular comorbidities?

Output: age, concur -rent medications, drug adherence, drug interactions, the over -all treatment regimen, out-of-pocket costs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are specific cardiovascular comorbidities?. ### Response: age, concur -rent medications, drug adherence, drug interactions, the over -all treatment regimen, out-of-pocket costs.


Instruction: When the initial drug treatment of high BP is being considered, how many different strategies may be considered?

Output: several

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When the initial drug treatment of high BP is being considered, how many different strategies may be considered?. ### Response: several.


Instruction: How many patients can be started on a single agent?

Output: ≥2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients can be started on a single agent?. ### Response: ≥2.


Instruction: How many drugs of different classes for those with stage 2 hypertension?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many drugs of different classes for those with stage 2 hypertension?. ### Response: 2.


Instruction: What should be considered in addition to age, concur-rent medications, drug adherence, drug interactions, the over-all treatment regimen, out-of-pocket costs, and comorbidities?

Output: patient-specific factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered in addition to age, concur-rent medications, drug adherence, drug interactions, the over-all treatment regimen, out-of-pocket costs, and comorbidities?. ### Response: patient-specific factors.


Instruction: What must be taken into account from a societal perspective?

Output: total costs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must be taken into account from a societal perspective?. ### Response: total costs.


Instruction: What should drive the ulti-mate choice of antihypertensive agent(s)?

Output: Shared decision making

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should drive the ulti-mate choice of antihypertensive agent(s)?. ### Response: Shared decision making.


Instruction: How many patients will require 2 drugs from different pharmacological classes to reach their BP goals?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients will require 2 drugs from different pharmacological classes to reach their BP goals?. ### Response: ≥.


Instruction: What do drugs from different pharmacological classes do to reach their BP goals?

Output: ≥2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do drugs from different pharmacological classes do to reach their BP goals?. ### Response: ≥2.


Instruction: What is important to know about each agent?

Output: pharmacological mechanisms of action

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is important to know about each agent?. ### Response: pharmacological mechanisms of action.


Instruction: How can drug regimens with complementary activity result?

Output: additive lowering of BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can drug regimens with complementary activity result?. ### Response: additive lowering of BP.


Instruction: What may be achieved by adding an ACE inhibitor or ARB to the thiazide?

Output: an additive BP-lowering effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be achieved by adding an ACE inhibitor or ARB to the thiazide?. ### Response: an additive BP-lowering effect.


Instruction: What may also improve adherence?

Output: Use of combination therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may also improve adherence?. ### Response: Use of combination therapy.


Instruction: How many fixed-dose drug combinations are available?

Output: 2- and 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many fixed-dose drug combinations are available?. ### Response: 2- and 3.


Instruction: What may contain a lower-than-optimal dose of thiazide diuretic?

Output: triple-dose combinations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may contain a lower-than-optimal dose of thiazide diuretic?. ### Response: triple-dose combinations.


Instruction: What is a summary of oral antihypertensive drugs?

Output: Table 18

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a summary of oral antihypertensive drugs?. ### Response: Table 18.


Instruction: How many drugs from the same class should not be administered?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many drugs from the same class should not be administered?. ### Response: 2.


Instruction: What is the name of the Thrombosis: Risk and Economic Assessment of Thrombophilia Screening study?

Output: TREATS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Thrombosis: Risk and Economic Assessment of Thrombophilia Screening study?. ### Response: TREATS.


Instruction: What is a possible migraine with visual aura and risk of isch-emic stroke?

Output: the Stroke Prevention in Young Women Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a possible migraine with visual aura and risk of isch-emic stroke?. ### Response: the Stroke Prevention in Young Women Study.


Instruction: What is the risk of isch-emic stroke associated with migraine?

Output: use of combined oral contraceptives and hormone replacement therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of isch-emic stroke associated with migraine?. ### Response: use of combined oral contraceptives and hormone replacement therapy.


Instruction: When was the Stroke Prevention in Young Women Study published?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Stroke Prevention in Young Women Study published?. ### Response: 2007.


Instruction: What was the name of the Task Force on Combined Oral Contraceptives & Hormone Replacement Therapy?

Output: International Headache Society

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the Task Force on Combined Oral Contraceptives & Hormone Replacement Therapy?. ### Response: International Headache Society.


Instruction: What is the risk of ischaemic stroke associated with use of combined oral contraceptives and hormone replacement therapy in women with migraine?

Output: Recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of ischaemic stroke associated with use of combined oral contraceptives and hormone replacement therapy in women with migraine?. ### Response: Recommendations.


Instruction: What study investigators were involved in the ENIGMA Study?

Output: Hickson SS, Miles KL, McDonnell BJ, Yasmin, Cockcroft JR, Wilkinson IB, McEniery CM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What study investigators were involved in the ENIGMA Study?. ### Response: Hickson SS, Miles KL, McDonnell BJ, Yasmin, Cockcroft JR, Wilkinson IB, McEniery CM.


Instruction: Who were the ENIGMA Study Investigators?

Output: Hickson SS, Miles KL, McDonnell BJ, Yasmin, Cockcroft JR, Wilkinson IB, McEniery CM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who were the ENIGMA Study Investigators?. ### Response: Hickson SS, Miles KL, McDonnell BJ, Yasmin, Cockcroft JR, Wilkinson IB, McEniery CM.


Instruction: When was the oral version of the study published?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the oral version of the study published?. ### Response: April 28, 2023.


Instruction: What is the name of the organization that was involved in the study?

Output: ENIGMA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that was involved in the study?. ### Response: ENIGMA.


Instruction: Prasugrel and ticagrelor are added to this guideline on the basis of the results of what trial?

Output: TRITON-TIMI 38

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Prasugrel and ticagrelor are added to this guideline on the basis of the results of what trial?. ### Response: TRITON-TIMI 38.


Instruction: PLATO is a study of what?

Output: Platelet Inhibition and PatientOutcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: PLATO is a study of what?. ### Response: Platelet Inhibition and PatientOutcomes.


Instruction: What does the present update continue to recommend for chronic therapy?

Output: lower -dose aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the present update continue to recommend for chronic therapy?. ### Response: lower -dose aspirin.


Instruction: What has further confirmed the benefit of aldosterone antagoni sttherapy among patients with impaired left ventricular function?

Output: The results of additional studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has further confirmed the benefit of aldosterone antagoni sttherapy among patients with impaired left ventricular function?. ### Response: The results of additional studies.


Instruction: What has been clarified to reflect the fact that evidence supporting their efficacy is greates t among patients with recent myocardial infarction?

Output: /H9252-blocker therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been clarified to reflect the fact that evidence supporting their efficacy is greates t among patients with recent myocardial infarction?. ### Response: /H9252-blocker therapy.


Instruction: What are the current recommendations for angiotensin-conve rtingenzyme inhibitor therapy?

Output: therapies in appropriate patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the current recommendations for angiotensin-conve rtingenzyme inhibitor therapy?. ### Response: therapies in appropriate patients.


Instruction: What is the efficacy of H9252-blocker therapy among patients with recent myocardial infarction and/or leftventricular systolic dysfunction?

Output: greates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the efficacy of H9252-blocker therapy among patients with recent myocardial infarction and/or leftventricular systolic dysfunction?. ### Response: greates.


Instruction: What is optional for patients without Class I indications?

Output: /H9252-blocker therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is optional for patients without Class I indications?. ### Response: /H9252-blocker therapy.


Instruction: In what year was the recommendation for inactivated influenza vaccine introduced?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was the recommendation for inactivated influenza vaccine introduced?. ### Response: 2006.


Instruction: What is vaccinated for people who have chronic disorders of the cardiovascular system because they are at increased risk for complications?

Output: inactivated influenza vaccine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is vaccinated for people who have chronic disorders of the cardiovascular system because they are at increased risk for complications?. ### Response: inactivated influenza vaccine.


Instruction: Who is at increased risk for complications from influenza?

Output: individuals who have chronic disorders of the cardiovas cularsystem

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is at increased risk for complications from influenza?. ### Response: individuals who have chronic disorders of the cardiovas cularsystem.


Instruction: What did the writing group add new sections on?

Output: depression

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the writing group add new sections on?. ### Response: depression.


Instruction: What do randomized clinical trials strengthen?

Output: evidence-based foundation f ortherapeutic application of these guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do randomized clinical trials strengthen?. ### Response: evidence-based foundation f ortherapeutic application of these guidelines.


Instruction: Who is re-underrepresented in many trials?

Output: ethnic minorities, women, and the elderly

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is re-underrepresented in many trials?. ### Response: ethnic minorities, women, and the elderly.


Instruction: How many years have passed since the guidelines were first published?

Output: 15

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many years have passed since the guidelines were first published?. ### Response: 15.


Instruction: The aging of the population continues toexpand the number of patients living with what disease?

Output: cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The aging of the population continues toexpand the number of patients living with what disease?. ### Response: cardiovascular disease.


Instruction: What is the estimated number of patients living with a diagnosis ofcardiovascular disease?

Output: 16.3 million

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the estimated number of patients living with a diagnosis ofcardiovascular disease?. ### Response: 16.3 million.


Instruction: How many patients are estimated to benefit from these therapies?

Output: 16.3 million

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients are estimated to benefit from these therapies?. ### Response: 16.3 million.


Instruction: Multiple studies of the use of these recommended therapies in appropriate patients continue to show what?

Output: slowimprovement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Multiple studies of the use of these recommended therapies in appropriate patients continue to show what?. ### Response: slowimprovement.


Instruction: The AHA andACCF recommend the use of what programs?

Output: AHA’

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The AHA andACCF recommend the use of what programs?. ### Response: AHA’.


Instruction: What is one program that the AHA recommends?

Output: AHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one program that the AHA recommends?. ### Response: AHA.


Instruction: What should be assessed at eachpatient encounter?

Output: Volume status and vital signs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be assessed at eachpatient encounter?. ### Response: Volume status and vital signs.


Instruction: What can be useful to estimate the subsequent risk of mortality in patients?

Output: Validated multivariable risk scores

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be useful to estimate the subsequent risk of mortality in patients?. ### Response: Validated multivariable risk scores.


Instruction: What can be used to estimate the subsequent risk of mortality in ambulatory or hospitalizedpatients with HF?

Output: Validated multivariable risk scores

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be used to estimate the subsequent risk of mortality in ambulatory or hospitalizedpatients with HF?. ### Response: Validated multivariable risk scores.


Instruction: What is the level of evidence for HF inpatients?

Output: C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the level of evidence for HF inpatients?. ### Response: C.


Instruction: What is the first laboratory evaluation of a patient presenting withHF that should include complete blood count, urinalysis and serum electro-lytes?

Output: Diagnostic TestsCLASS I1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the first laboratory evaluation of a patient presenting withHF that should include complete blood count, urinalysis and serum electro-lytes?. ### Response: Diagnostic TestsCLASS I1.


Instruction: What should be performed on all patients presenting with HF?

Output: A 12-lead electrocardiogram

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be performed on all patients presenting with HF?. ### Response: A 12-lead electrocardiogram.


Instruction: What should include serumelectrolytes and renal function?

Output: Serial monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should include serumelectrolytes and renal function?. ### Response: Serial monitoring.


Instruction: What is reasonable in selectedpatients who present with HF (63)?

Output: romatosis or HIV

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable in selectedpatients who present with HF (63)?. ### Response: romatosis or HIV.


Instruction: What are reasonable in patients presentingwith HF in whom there is a clinical suspicion of these diseases?

Output: Diagnostic tests for rheumatologic diseases, amyloidosis, orpheochromocytoma

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are reasonable in patients presentingwith HF in whom there is a clinical suspicion of these diseases?. ### Response: Diagnostic tests for rheumatologic diseases, amyloidosis, orpheochromocytoma.


Instruction: What type of peptide is useful in ambulatory patients with dyspnea?

Output: B-type natriuretic peptide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of peptide is useful in ambulatory patients with dyspnea?. ### Response: B-type natriuretic peptide.


Instruction: What is N-terminal pro-B-typenatriureticpeptide?

Output: NT-proBNP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is N-terminal pro-B-typenatriureticpeptide?. ### Response: NT-proBNP.


Instruction: What can support clinical decision making regarding the diagnosis of HF?

Output: Measurement of BNP or NT-proBNP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can support clinical decision making regarding the diagnosis of HF?. ### Response: Measurement of BNP or NT-proBNP.


Instruction: What can be useful to achieve optimal dosing?

Output: BNP- or NT-proBNP Lguided HF therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be useful to achieve optimal dosing?. ### Response: BNP- or NT-proBNP Lguided HF therapy.


Instruction: How can BNP- or NT-proBNP Lguided HF therapy be useful?

Output: toachieve optimal dosing of GDMT in select clinically euvole-mic patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can BNP- or NT-proBNP Lguided HF therapy be useful?. ### Response: toachieve optimal dosing of GDMT in select clinically euvole-mic patients.


Instruction: What can be useful to achieve optimal dosing of GDMT in select clinical euvolemic patients?

Output: BNP- or NT-proBNP Lguided HF therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be useful to achieve optimal dosing of GDMT in select clinical euvolemic patients?. ### Response: BNP- or NT-proBNP Lguided HF therapy.


Instruction: What is not well established about the usefulness of serial measurement of BNP?

Output: to reduce hospitalization or mortality in patients with HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not well established about the usefulness of serial measurement of BNP?. ### Response: to reduce hospitalization or mortality in patients with HF.


Instruction: What is not well established in patients with HF?

Output: The usefulness of serial measurement of BNP or NT-proBNPto reduce hospitalization or mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not well established in patients with HF?. ### Response: The usefulness of serial measurement of BNP or NT-proBNPto reduce hospitalization or mortality.


Instruction: What may be considered for additive risk strati fication in chronicHF patients?

Output: Measurement of BNP or NT-proBNP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered for additive risk strati fication in chronicHF patients?. ### Response: Measurement of BNP or NT-proBNP.


Instruction: How is BNP useful to supportclinical judgment?

Output: Measurement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is BNP useful to supportclinical judgment?. ### Response: Measurement.


Instruction: What is useful to supportclinical judgment for the diagnosis of acute decompensated HF?

Output: Measurement of BNP or NT-proBNP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is useful to supportclinical judgment for the diagnosis of acute decompensated HF?. ### Response: Measurement of BNP or NT-proBNP.


Instruction: What is helpful in the setting of uncertainty for thediagnosis?

Output: Measurement of BNP or NT-proBNP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is helpful in the setting of uncertainty for thediagnosis?. ### Response: Measurement of BNP or NT-proBNP.


Instruction: How many patients have chronic HFS?

Output: 85–91

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients have chronic HFS?. ### Response: 85–91.


Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: http://SeattleHeartFailureModel.org?. ### Response: http://SeattleHeartFailureModel.org.


Instruction: What is the TAVI registry?

Output: TOPAS-TAVI registry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the TAVI registry?. ### Response: TOPAS-TAVI registry.


Instruction: When did Schewel J, Schlüter M, Schmidt T, et al. report on the early haemodynamic changes and long-term outcome of patients with severe low-gradient aortic stenosis?

Output: 31

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Schewel J, Schlüter M, Schmidt T, et al. report on the early haemodynamic changes and long-term outcome of patients with severe low-gradient aortic stenosis?. ### Response: 31.


Instruction: What was the name of the registry that was published in 2018?

Output: TOPAS-TAVI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the registry that was published in 2018?. ### Response: TOPAS-TAVI.


Instruction: What is a substudy from the TOPAS-TAVI registry?

Output: left ventricular ejection fraction less than 30%:

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a substudy from the TOPAS-TAVI registry?. ### Response: left ventricular ejection fraction less than 30%:.


Instruction: What does Elmariah S, Fearon WF, Inglessis I, et al. do?

Output: Transapical transcatheter aortic valve replacement is associated with increased cardiac mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Elmariah S, Fearon WF, Inglessis I, et al. do?. ### Response: Transapical transcatheter aortic valve replacement is associated with increased cardiac mortality.


Instruction: What is associated with increased cardiac mortality in patients with left ventricular dysfunction?

Output: Transapical transcatheter aortic valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with increased cardiac mortality in patients with left ventricular dysfunction?. ### Response: Transapical transcatheter aortic valve replacement.


Instruction: What is the JACC Cardiovasc Interv. 2017;10:2414–22?

Output: Transapical transcatheter aortic valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the JACC Cardiovasc Interv. 2017;10:2414–22?. ### Response: Transapical transcatheter aortic valve replacement.


Instruction: What type of stenosis can be treated with a transcatheter aortic valve replacement?

Output: severe aortic stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of stenosis can be treated with a transcatheter aortic valve replacement?. ### Response: severe aortic stenosis.


Instruction: What is the name of the registry that provides insights into the outcomes of urgent/emergency transcatherter valve replacements?

Output: STS/ACC TVT registry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the registry that provides insights into the outcomes of urgent/emergency transcatherter valve replacements?. ### Response: STS/ACC TVT registry.


Instruction: How many years ago did N Engl J Med issue 366:1696–704?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many years ago did N Engl J Med issue 366:1696–704?. ### Response: 2012.


Instruction: What is the CURRENT AS registry used for?

Output: Acute heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the CURRENT AS registry used for?. ### Response: Acute heart failure.


Instruction: What is aortic valvu-loplasty used for in the management of patients with stenosis?

Output: Usefulness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is aortic valvu-loplasty used for in the management of patients with stenosis?. ### Response: Usefulness.


Instruction: What procedure is used in the management of patients with aortic stenosis?

Output: balloon aortic valvu-loplasty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What procedure is used in the management of patients with aortic stenosis?. ### Response: balloon aortic valvu-loplasty.


Instruction: What year did Am J Cardiol. 2017:120:1366–72?

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Am J Cardiol. 2017:120:1366–72?. ### Response: 2017.


Instruction: How did Bongiovanni D, Kühl C, Bleiziffer S, et al. treat decompensated Aortic Stenosis in 2018?

Output: Emergency treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Bongiovanni D, Kühl C, Bleiziffer S, et al. treat decompensated Aortic Stenosis in 2018?. ### Response: Emergency treatment.


Instruction: AORTIC REGURGITATION4.1.1. Diagnosis of AR 1.

Output: 23–9.4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: AORTIC REGURGITATION4.1.1. Diagnosis of AR 1.. ### Response: 23–9.4.


Instruction: What is a clinical classification for the perioperative echocardiog-rapher in the era of echocardiography?

Output: ortic regurgitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a clinical classification for the perioperative echocardiog-rapher in the era of echocardiography?. ### Response: ortic regurgitation.


Instruction: What is an example of an aortic regurgitation?

Output: acute type-A aortic dissection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of an aortic regurgitation?. ### Response: acute type-A aortic dissection.


Instruction: What is the clinical classification for the perioperative echocardiog-rapher in the era of the functional aortic annulus?

Output: Aortic regurgitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the clinical classification for the perioperative echocardiog-rapher in the era of the functional aortic annulus?. ### Response: Aortic regurgitation.


Instruction: What is Hamirani YS, Dietl CA, Voyles W, et al.?

Output: Acute aortic regurgitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Hamirani YS, Dietl CA, Voyles W, et al.?. ### Response: Acute aortic regurgitation.


Instruction: Where is Stout KK, Verrier ED?

Output: Circulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Stout KK, Verrier ED?. ### Response: Circulation.


Instruction: What is valvular regurgitation?

Output: Acute

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is valvular regurgitation?. ### Response: Acute.


Instruction: What is the effect of early surgery on in-hospital mortality of native valve endocarditis?

Output: increased cardiac mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of early surgery on in-hospital mortality of native valve endocarditis?. ### Response: increased cardiac mortality.


Instruction: How does the propensity score and instrumental variable methods adjust for treatment-selection bias?

Output: Analysis of the impact of early sur -gery on in-hospital mortality of native valve endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does the propensity score and instrumental variable methods adjust for treatment-selection bias?. ### Response: Analysis of the impact of early sur -gery on in-hospital mortality of native valve endocarditis.


Instruction: What is bias in Circulation?

Output: treatment-selection bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is bias in Circulation?. ### Response: treatment-selection bias.


Instruction: What is a clinical classification for the perioperative echocardiog-rapher in the era of the functional aortic annulus?

Output: Aortic regurgitation in acute type-A aortic dissection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a clinical classification for the perioperative echocardiog-rapher in the era of the functional aortic annulus?. ### Response: Aortic regurgitation in acute type-A aortic dissection.


Instruction: What is the basis for the assumed risk?

Output: the median control group risk across studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the basis for the assumed risk?. ### Response: the median control group risk across studies.


Instruction: What percentage of the corresponding risk is based on the assumption risk in the study?

Output: 95% CI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the corresponding risk is based on the assumption risk in the study?. ### Response: 95% CI.


Instruction: What is the 95% CI of the intervention based on?

Output: relative effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 95% CI of the intervention based on?. ### Response: relative effect.


Instruction: What are the grades of evidence in the GRADE Working Group?

Output: a

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the grades of evidence in the GRADE Working Group?. ### Response: a.


Instruction: Who had completed 6 to 12 mo of anticoagulation therapy?

Output: Patients with VTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who had completed 6 to 12 mo of anticoagulation therapy?. ### Response: Patients with VTE.


Instruction: What was Apixaban 2.5 mg twice-daily dose vs placebo?

Output: aPatients with VTE who had completed 6 to 12 mo of anticoagulation therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was Apixaban 2.5 mg twice-daily dose vs placebo?. ### Response: aPatients with VTE who had completed 6 to 12 mo of anticoagulation therapy.


Instruction: What is ventricular tachycardia?

Output: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ventricular tachycardia?. ### Response: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society.


Instruction: What is the name of the Task Force on Clinical Practice Guidelines and the Heart Rhythm Society?

Output: American College of Cardiology/American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Clinical Practice Guidelines and the Heart Rhythm Society?. ### Response: American College of Cardiology/American Heart Association.


Instruction: What does PACES stand for?

Output: Pediatric and Congenital Electrophysiology Society

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does PACES stand for?. ### Response: Pediatric and Congenital Electrophysiology Society.


Instruction: What is HRS a part of?

Output: Heart Rhythm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is HRS a part of?. ### Response: Heart Rhythm.


Instruction: Who developed Heart Rhythm?

Output: Pediatric and Congenital Electrophysiology Society (PACES) and the Heart Rhythm Society

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who developed Heart Rhythm?. ### Response: Pediatric and Congenital Electrophysiology Society (PACES) and the Heart Rhythm Society.


Instruction: What is the acronym for Wolff-Parkinson-White?

Output: WPW

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Wolff-Parkinson-White?. ### Response: WPW.


Instruction: What does ACCF stand for?

Output: American College of Cardiology Foundation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ACCF stand for?. ### Response: American College of Cardiology Foundation.


Instruction: What is the acronym for the Heart Rhythm Society?

Output: HRS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the Heart Rhythm Society?. ### Response: HRS.


Instruction: What predicts major adverse clinical out-comes late after tetralogy of Fallot repair?

Output: Ventricular size and func-tion assessed by cardiac MRI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What predicts major adverse clinical out-comes late after tetralogy of Fallot repair?. ### Response: Ventricular size and func-tion assessed by cardiac MRI.


Instruction: What type of repair does Fallot repair?

Output: surgical

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of repair does Fallot repair?. ### Response: surgical.


Instruction: What is the risk of coronary ar tery compression among patients referred for transcatheter pulmo-nary valve implantation: a multicenter experience?

Output: Risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of coronary ar tery compression among patients referred for transcatheter pulmo-nary valve implantation: a multicenter experience?. ### Response: Risk.


Instruction: Who wrote the PACES/HRS expert consensus statement?

Output: Khairy P ,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote the PACES/HRS expert consensus statement?. ### Response: Khairy P ,.


Instruction: Who developed the consensus statement on the recognition and management of arrhythmias in adult congenital heart disease?

Output: PACES/HRS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who developed the consensus statement on the recognition and management of arrhythmias in adult congenital heart disease?. ### Response: PACES/HRS.


Instruction: What is the name of the partnership between the Pediatric and Congenital Electrophysiology Society and the Heart Rhythm Society?

Output: PACES

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the partnership between the Pediatric and Congenital Electrophysiology Society and the Heart Rhythm Society?. ### Response: PACES.


Instruction: What is the value of programmed ventricular stimulation after tetralogy of Fallot?

Output: S4.3.5-6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the value of programmed ventricular stimulation after tetralogy of Fallot?. ### Response: S4.3.5-6.


Instruction: What is a life-threatening arrhyth-mias and RV dysfunction after surgical repair?

Output: tetralogy of Fallot

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a life-threatening arrhyth-mias and RV dysfunction after surgical repair?. ### Response: tetralogy of Fallot.


Instruction: What is the value of programmed ventricular stimulation after tetralogy of Fallot repair?

Output: a

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the value of programmed ventricular stimulation after tetralogy of Fallot repair?. ### Response: a.


Instruction: When was the study conducted?

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the study conducted?. ### Response: 2016.


Instruction: What was the rate of inducible ventricular ar -rhythmia in adults with congenital heart disease?

Output: 730–6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the rate of inducible ventricular ar -rhythmia in adults with congenital heart disease?. ### Response: 730–6.


Instruction: What is a Bayesian perspective on ventricular stimulation in Fallot patients?

Output: Programmed ventricular stimulation for risk stratification

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a Bayesian perspective on ventricular stimulation in Fallot patients?. ### Response: Programmed ventricular stimulation for risk stratification.


Instruction: When did Khairy publish his paper?

Output: 1994

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Khairy publish his paper?. ### Response: 1994.


Instruction: What is the name of the paper he published in 2007?

Output: Nat Clin Pract Cardiovasc Med

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the paper he published in 2007?. ### Response: Nat Clin Pract Cardiovasc Med.


Instruction: What are the differences in glucose tolerance between fixed-dose antihypertensive drug combinations in people withmetabolic syndrome?

Output: ﬁ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the differences in glucose tolerance between fixed-dose antihypertensive drug combinations in people withmetabolic syndrome?. ### Response: ﬁ.


Instruction: What is the National Clinical Guideline Center's Hypertension. The Clinical Manage-ment of Primary Hypertension in Adults?

Output: Clinical Guideline 127

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the National Clinical Guideline Center's Hypertension. The Clinical Manage-ment of Primary Hypertension in Adults?. ### Response: Clinical Guideline 127.


Instruction: What is Clinical Guideline 127?

Output: The Clinical Manage-ment of Primary Hypertension in Adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Clinical Guideline 127?. ### Response: The Clinical Manage-ment of Primary Hypertension in Adults.


Instruction: What is the National Institute for Health and Clinical Excellence?

Output: National Clinical Guideline Center. Hypertension. The Clinical Manage-ment of Primary Hypertension in Adults. Clinical Guideline 127

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the National Institute for Health and Clinical Excellence?. ### Response: National Clinical Guideline Center. Hypertension. The Clinical Manage-ment of Primary Hypertension in Adults. Clinical Guideline 127.


Instruction: Who is the Expert RevCardiovasc?

Output: Expert RevCardiovasc Ther

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Expert RevCardiovasc?. ### Response: Expert RevCardiovasc Ther.


Instruction: What is thiazide?

Output: thiazide-like diuretics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is thiazide?. ### Response: thiazide-like diuretics.


Instruction: What is the name of the randomized trial of offurosemide vs hydrochlorothiazide in patients with chronic renal failure and hypertension?

Output: offurosemide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized trial of offurosemide vs hydrochlorothiazide in patients with chronic renal failure and hypertension?. ### Response: offurosemide.


Instruction: What is the name of the cochrane database for hypertension?

Output: Syst Rev2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the cochrane database for hypertension?. ### Response: Syst Rev2009.


Instruction: What does Bakris G focus on in his analysis of vasodilation in the management of?

Output: adrenergic blockade

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Bakris G focus on in his analysis of vasodilation in the management of?. ### Response: adrenergic blockade.


Instruction: What is the name of the subcommittee report on beta-adrenergic blockers?

Output: Oregon Health Resources Commission. Beta Adrenergic Blockers Pharma-ceutical Subcommittee Report

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the subcommittee report on beta-adrenergic blockers?. ### Response: Oregon Health Resources Commission. Beta Adrenergic Blockers Pharma-ceutical Subcommittee Report.


Instruction: What are the current guidelines for the use of beta-blockers in hypertension?

Output: pharmacokinetic considerations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the current guidelines for the use of beta-blockers in hypertension?. ### Response: pharmacokinetic considerations.


Instruction: When was the last update on Beta-Adrenergic blockers published?

Output: March 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last update on Beta-Adrenergic blockers published?. ### Response: March 2008.


Instruction: What is one of the results of a systematic review and meta-analysis of the effects of beta-agonists in chronic kidney disease?

Output: randomized trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the results of a systematic review and meta-analysis of the effects of beta-agonists in chronic kidney disease?. ### Response: randomized trial.


Instruction: What are beta-blockers used for as a second line therapy for primary hypertension?

Output: Blood pressure lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are beta-blockers used for as a second line therapy for primary hypertension?. ### Response: Blood pressure lowering.


Instruction: What is the name of the 2010 CochraneDatabase Syst Rev :CD007185.128?

Output: Ritz E, Rump LC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2010 CochraneDatabase Syst Rev :CD007185.128?. ### Response: Ritz E, Rump LC.


Instruction: How does RAS protect against renal injury?

Output: offurosemide vs hydrochlorothiazide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does RAS protect against renal injury?. ### Response: offurosemide vs hydrochlorothiazide.


Instruction: What year did the Curr Hypertens Rep publish 9:409–414.129?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did the Curr Hypertens Rep publish 9:409–414.129?. ### Response: 2007.


Instruction: What is the name of the study that focuses on calcium-channel blockers and end-stage renal disease?

Output: Calcium Channel Blocker Sub-committee Report Update #2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that focuses on calcium-channel blockers and end-stage renal disease?. ### Response: Calcium Channel Blocker Sub-committee Report Update #2.


Instruction: When was the last issue of Curr OpinNephrol hypertens?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last issue of Curr OpinNephrol hypertens?. ### Response: 2003.


Instruction: What subclasses are on markers of nephropathy progression?

Output: calciumantagonist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What subclasses are on markers of nephropathy progression?. ### Response: calciumantagonist.


Instruction: What is the name of the sub-committee report on calcium channel blockers?

Output: Update #2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the sub-committee report on calcium channel blockers?. ### Response: Update #2.


Instruction: When did the Oregon Health Resources Commission publish the Calcium Channel Blocker Report Update #2?

Output: May 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Oregon Health Resources Commission publish the Calcium Channel Blocker Report Update #2?. ### Response: May 2005.


Instruction: What is Moxonidine used for in essential hypertension?

Output: a review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Moxonidine used for in essential hypertension?. ### Response: a review.


Instruction: What is the name of the drug that has been reviewed in critical hypertension in 2006?

Output: Moxonidine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug that has been reviewed in critical hypertension in 2006?. ### Response: Moxonidine.


Instruction: Who is the author of Centrally acting antihypertensive agents: an update?

Output: Sica DA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of Centrally acting antihypertensive agents: an update?. ### Response: Sica DA.


Instruction: What is another term for cancer-associated thrombosis?

Output: cancer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for cancer-associated thrombosis?. ### Response: cancer.


Instruction: How long does extended anticoagulant therapy last?

Output: 3 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does extended anticoagulant therapy last?. ### Response: 3 months.


Instruction: What is the grade 1B of therapy?

Output: 3 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the grade 1B of therapy?. ### Response: 3 months.


Instruction: What is the Grade 2B of anticoagulant therapy?

Output: recurrent VTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Grade 2B of anticoagulant therapy?. ### Response: recurrent VTE.


Instruction: What should be reassessed at periodic intervals?

Output: continuing use of treatments

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be reassessed at periodic intervals?. ### Response: continuing use of treatments.


Instruction: Aspirin is expected to be much lesseffective at preventing recurrent VTE than what?

Output: anticoagulants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Aspirin is expected to be much lesseffective at preventing recurrent VTE than what?. ### Response: anticoagulants.


Instruction: What do PE who are stopping anticoagulant therapy not have a contraindication to?

Output: aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do PE who are stopping anticoagulant therapy not have a contraindication to?. ### Response: aspirin.


Instruction: What is a reasonablealternative to anticoagulant therapy in patients whowant extended therapy?

Output: serial imaging of thedeep veins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a reasonablealternative to anticoagulant therapy in patients whowant extended therapy?. ### Response: serial imaging of thedeep veins.


Instruction: What is one of the benefits of aspirin that needs to bebalanced against the risk of bleeding andinconvenience?

Output: VTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the benefits of aspirin that needs to bebalanced against the risk of bleeding andinconvenience?. ### Response: VTE.


Instruction: What should be reevaluated when patients stop anticoagulant therapy?

Output: Use of aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be reevaluated when patients stop anticoagulant therapy?. ### Response: Use of aspirin.


Instruction: What is a common cause of isolated distal DVT of the leg?

Output: forextension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a common cause of isolated distal DVT of the leg?. ### Response: forextension.


Instruction: What type of imaging is recommended for 2 weeks over anticoagulation (Grade 2C)or (ii) with severe symptoms or risk factors forjournal.publications.chestnet.org 317

Output: serial imaging of thedeep veins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of imaging is recommended for 2 weeks over anticoagulation (Grade 2C)or (ii) with severe symptoms or risk factors forjournal.publications.chestnet.org 317. ### Response: serial imaging of thedeep veins.


Instruction: What crevice around teeth releases many different microbial species into the bloodstream?

Output: gingival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What crevice around teeth releases many different microbial species into the bloodstream?. ### Response: gingival.


Instruction: What happens frequently in association with dental extractions or other routine daily activities?

Output: Transient bacteremia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What happens frequently in association with dental extractions or other routine daily activities?. ### Response: Transient bacteremia.


Instruction: What is believed to be related to the nature and intensity of tissue trauma?

Output: the frequency and intensity of the resultingbacteremias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is believed to be related to the nature and intensity of tissue trauma?. ### Response: the frequency and intensity of the resultingbacteremias.


Instruction: What is the density of the microbialflora and the degree of inflammation or infection at the site of trauma related to?

Output: tissue trauma

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the density of the microbialflora and the degree of inflammation or infection at the site of trauma related to?. ### Response: tissue trauma.


Instruction: How do bacterial species enter the circulation?

Output: unique endogenous microflora

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do bacterial species enter the circulation?. ### Response: unique endogenous microflora.


Instruction: What determines the anatomic localization of infection caused by microorganisms?

Output: Bacterial AdherenceThe ability of various microbial species to adhere to specificsites

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What determines the anatomic localization of infection caused by microorganisms?. ### Response: Bacterial AdherenceThe ability of various microbial species to adhere to specificsites.


Instruction: Mediators of what serve as virulence factors in the pathogenesis of IE?

Output: bacterial adherences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Mediators of what serve as virulence factors in the pathogenesis of IE?. ### Response: bacterial adherences.


Instruction: What are numerous bacterial surface components present in streptococci,staphylococci, and enterococci shown to function as?

Output: criticaladhesins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are numerous bacterial surface components present in streptococci,staphylococci, and enterococci shown to function as?. ### Response: criticaladhesins.


Instruction: Some viridans group what?

Output: streptococci

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Some viridans group what?. ### Response: streptococci.


Instruction: What is a lipoprotein receptor antigen I?

Output: FimAprotein

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a lipoprotein receptor antigen I?. ### Response: FimAprotein.


Instruction: What serves as a major adhesin to the fibrin platelet matrix ofNBTE?

Output: FimAprotein

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What serves as a major adhesin to the fibrin platelet matrix ofNBTE?. ### Response: FimAprotein.


Instruction: How many ways do staphylococcal adhesions function?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many ways do staphylococcal adhesions function?. ### Response: 2.


Instruction: What surface components recognize adhesivematrix molecules?

Output: microbial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What surface components recognize adhesivematrix molecules?. ### Response: microbial.


Instruction: What do bacterial extracellular structures contribute to the formation of on the surface of implantedmedical devices?

Output: biofilm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do bacterial extracellular structures contribute to the formation of on the surface of implantedmedical devices?. ### Response: biofilm.


Instruction: What are important virulence factors in both cases?

Output: staphylococcal adhesins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are important virulence factors in both cases?. ### Response: staphylococcal adhesins.


Instruction: FimA and staphylococcal adhesins are what type of experimental infections?

Output: immunogenic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: FimA and staphylococcal adhesins are what type of experimental infections?. ### Response: immunogenic.


Instruction: What do vaccines prepared against FimAand staphylococcal adhesins provide some protective effect in?

Output: inexperimental endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do vaccines prepared against FimAand staphylococcal adhesins provide some protective effect in?. ### Response: inexperimental endocarditis.


Instruction: What is caused by viridans group strepto-cocci and staphyllococci?

Output: endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is caused by viridans group strepto-cocci and staphyllococci?. ### Response: endocarditis.


Instruction: Why are the results of these experimen-tal studies highly intriguing?

Output: the development ofan effective vaccine for use in humans

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why are the results of these experimen-tal studies highly intriguing?. ### Response: the development ofan effective vaccine for use in humans.


Instruction: What would be of major importance?

Output: development ofan effective vaccine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would be of major importance?. ### Response: development ofan effective vaccine.


Instruction: What stimulates furtherdeposition of fibrin and platelets on their surface?

Output: Proliferation of Bacteria Within a VegetationMicroorganisms adherent to the vegetation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What stimulates furtherdeposition of fibrin and platelets on their surface?. ### Response: Proliferation of Bacteria Within a VegetationMicroorganisms adherent to the vegetation.


Instruction: How do buried microorganisms multiply?

Output: as rap-idly as bacteria in broth cultures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do buried microorganisms multiply?. ### Response: as rap-idly as bacteria in broth cultures.


Instruction: How many colony-forming units per gram of vegetation?

Output: 108to 1011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many colony-forming units per gram of vegetation?. ### Response: 108to 1011.


Instruction: How long does it take for cultures to reach maximum microbialdensities?

Output: 108to 1011colony-forming units per gram ofvegetation within a short time

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take for cultures to reach maximum microbialdensities?. ### Response: 108to 1011colony-forming units per gram ofvegetation within a short time.


Instruction: 516. Gale CP, Cattle BA, Woolston A, et al. Reduced mortality in the elderly after acute coronary syndromes.

Output: Resolving inequalities in care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: 516. Gale CP, Cattle BA, Woolston A, et al. Reduced mortality in the elderly after acute coronary syndromes.. ### Response: Resolving inequalities in care.


Instruction: The Myocardial Ischaemia National Audit Project 2003-2010.

Output: 516. Gale CP, Cattle BA, Woolston A, et al. Resolving inequalities in care? Reduced mortality in the elderly after acute coronary syndromes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The Myocardial Ischaemia National Audit Project 2003-2010.. ### Response: 516. Gale CP, Cattle BA, Woolston A, et al. Resolving inequalities in care? Reduced mortality in the elderly after acute coronary syndromes.


Instruction: How long did it take for patients with high-risk non-ST-elevation acute coronary syndromes to be managed?

Output: 6-month

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for patients with high-risk non-ST-elevation acute coronary syndromes to be managed?. ### Response: 6-month.


Instruction: What is the name of the registry that tracks the management and outcomes of acute coronaries in elderly and very elderly patients?

Output: The Global Registry of Acute Coronary Events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the registry that tracks the management and outcomes of acute coronaries in elderly and very elderly patients?. ### Response: The Global Registry of Acute Coronary Events.


Instruction: When was the Eur Heart J.29:1275–82 published?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Eur Heart J.29:1275–82 published?. ### Response: 2008.


Instruction: How does age affect long-term outcomes after a routine invasive or selective invasive strategy in patients presenting with non-ST segment elevation acute coronary syndromes?

Output: Effects of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does age affect long-term outcomes after a routine invasive or selective invasive strategy in patients presenting with non-ST segment elevation acute coronary syndromes?. ### Response: Effects of age.


Instruction: What is the name of the collaborative analysis of individual data from the FRISC II - IC?

Output: Damman P, Clayton T, Wallentin L, et al. Effects of age on long-term outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the collaborative analysis of individual data from the FRISC II - IC?. ### Response: Damman P, Clayton T, Wallentin L, et al. Effects of age on long-term outcomes.