Instruction: Adequately powered studies show that treatment of patients with diabetes mellitus with a placebo reduces what risk of stroke?

Output: serious vascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Adequately powered studies show that treatment of patients with diabetes mellitus with a placebo reduces what risk of stroke?. ### Response: serious vascular events.


Instruction: What decreases the risk of a first stroke in patients with diabetes mellitus?

Output: a statin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What decreases the risk of a first stroke in patients with diabetes mellitus?. ### Response: a statin.


Instruction: Gemfi-brozil reduces stroke in men with what condition?

Output: diabetes mellitus and dyslip-idemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Gemfi-brozil reduces stroke in men with what condition?. ### Response: diabetes mellitus and dyslip-idemia.


Instruction: What effect was not seen in FIELD?

Output: fibrate effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What effect was not seen in FIELD?. ### Response: fibrate effect.


Instruction: What was not seen in FIELD?

Output: a fibrate effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not seen in FIELD?. ### Response: a fibrate effect.


Instruction: What found no benefit of adding fenofibrate to statin?

Output: ACCORD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What found no benefit of adding fenofibrate to statin?. ### Response: ACCORD.


Instruction: The subgroup analysis from fibrate trials suggests a benefit of fibrates in patients with diabetes mellitus?

Output: a BMI >30 kg/m2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The subgroup analysis from fibrate trials suggests a benefit of fibrates in patients with diabetes mellitus?. ### Response: a BMI >30 kg/m2.


Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al.


Instruction: What is the DOI: 10.1161/CIR.0000000000000923 February 2, 2021 e221?

Output: CLINICAL STATEMENTS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the DOI: 10.1161/CIR.0000000000000923 February 2, 2021 e221?. ### Response: CLINICAL STATEMENTS.


Instruction: What is the purpose of defining the intrinsic cardiac risks of opera-tions?

Output: to improve preoperative cardiac risk assessments

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of defining the intrinsic cardiac risks of opera-tions?. ### Response: to improve preoperative cardiac risk assessments.


Instruction: What are the results of this study?

Output: 1-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of this study?. ### Response: 1-year.


Instruction: How is functional capacity assessed before surgery?

Output: an international, prospective cohort study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is functional capacity assessed before surgery?. ### Response: an international, prospective cohort study.


Instruction: What is a new index for pre-operative cardiovascular evaluation?

Output: ACC/AHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a new index for pre-operative cardiovascular evaluation?. ### Response: ACC/AHA.


Instruction: What is the 2014 AHA/ACC guideline for the management of patients with valvular heart disease?

Output: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2014 AHA/ACC guideline for the management of patients with valvular heart disease?. ### Response: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.


Instruction: What did the American College of Cardiology/American Heart Association Task Force on Practice Guidelines do?

Output: line on perioperative cardiovascular evaluation and management of pa-tients undergoing noncardiac surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the American College of Cardiology/American Heart Association Task Force on Practice Guidelines do?. ### Response: line on perioperative cardiovascular evaluation and management of pa-tients undergoing noncardiac surgery.


Instruction: What is the name of the group that did a report on the management of patients with valvular heart disease?

Output: American College of Cardiology/American Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that did a report on the management of patients with valvular heart disease?. ### Response: American College of Cardiology/American Heart Association Task Force on Practice Guidelines.


Instruction: When was the ACCF/ASE/AHA/ASNC/HFSA/HRS/SCCM/SCCT/SCMR 2011?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the ACCF/ASE/AHA/ASNC/HFSA/HRS/SCCM/SCCT/SCMR 2011?. ### Response: 2011.


Instruction: What is an echocar-diography?

Output: American Society of Echocardiog-raphy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an echocar-diography?. ### Response: American Society of Echocardiog-raphy.


Instruction: What is the American College of Cardiology Foundation Appropriate Use Criteria Task Force?

Output: A report

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the American College of Cardiology Foundation Appropriate Use Criteria Task Force?. ### Response: A report.


Instruction: What is the Society for Cardiovascular Magnetic Resonance?

Output: So-ciety

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Society for Cardiovascular Magnetic Resonance?. ### Response: So-ciety.


Instruction: What is a 2014 ACC/AHA guideline on perioperative cardiovascular evaluation and management of patients?

Output: valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a 2014 ACC/AHA guideline on perioperative cardiovascular evaluation and management of patients?. ### Response: valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.


Instruction: What does the American College of Cardiology/American Heart Association Task Force on Practice Guidelines focus on?

Output: perioperative cardiovascular evaluation and management of pa-tients undergoing noncardiac surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the American College of Cardiology/American Heart Association Task Force on Practice Guidelines focus on?. ### Response: perioperative cardiovascular evaluation and management of pa-tients undergoing noncardiac surgery.


Instruction: What is the name of the group that compiled a report on the management of patients with valvular heart disease?

Output: American College of Cardiology/American Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that compiled a report on the management of patients with valvular heart disease?. ### Response: American College of Cardiology/American Heart Association Task Force on Practice Guidelines.


Instruction: When was the Circulation.129:e521–643?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circulation.129:e521–643?. ### Response: 2014.


Instruction: How is the aortic-valve replaced?

Output: self-expanding prosthesis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the aortic-valve replaced?. ### Response: self-expanding prosthesis.


Instruction: What is the name of the prosthesis that is self-expanding?

Output: Transcatheter aortic-valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prosthesis that is self-expanding?. ### Response: Transcatheter aortic-valve replacement.


Instruction: What year did N Engl J Med publish 370:1790–8?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did N Engl J Med publish 370:1790–8?. ### Response: 2014.


Instruction: How long did it take to achieve 2-Year outcomes in patients undergoing aortic valve replacement?

Output: 2015;66:113–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take to achieve 2-Year outcomes in patients undergoing aortic valve replacement?. ### Response: 2015;66:113–.


Instruction: Transcatheter versus surgical aortic valve replacement: 1-year results from the all-comers NOTION randomized clinical trial?

Output: Thyregod HGH, Steinbrüchel DA, Ihlemann N, et al. Transcatheter versus surgical aortic valve replacement in patients with severe aortic valve ste-nosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Transcatheter versus surgical aortic valve replacement: 1-year results from the all-comers NOTION randomized clinical trial?. ### Response: Thyregod HGH, Steinbrüchel DA, Ihlemann N, et al. Transcatheter versus surgical aortic valve replacement in patients with severe aortic valve ste-nosis.


Instruction: J Am Coll Cardiol 2015;65:2184–94.

Output: Transcatheter versus surgical aortic valve replacement in patients with severe aortic valve ste-nosis: 1-year results from the all-comers NOTION randomized clinical trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: J Am Coll Cardiol 2015;65:2184–94.. ### Response: Transcatheter versus surgical aortic valve replacement in patients with severe aortic valve ste-nosis: 1-year results from the all-comers NOTION randomized clinical trial.


Instruction: What is the name of the longitudinal subgroup analysis in SPRINT?

Output: longitudinals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the longitudinal subgroup analysis in SPRINT?. ### Response: longitudinals.


Instruction: What does intensive blood pressure lowering do for kidney tubule injury?

Output: Effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does intensive blood pressure lowering do for kidney tubule injury?. ### Response: Effects.


Instruction: What is kidney tubule injury in CKD?

Output: Effects of intensive bloodpressure lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is kidney tubule injury in CKD?. ### Response: Effects of intensive bloodpressure lowering.


Instruction: What is the name of the longitudinalsubgroup analysis in SPRINT?

Output: Effects of intensive bloodpressure lowering on kidney tubule injury in CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the longitudinalsubgroup analysis in SPRINT?. ### Response: Effects of intensive bloodpressure lowering on kidney tubule injury in CKD.


Instruction: What year did Intern Med publish 169:610–618?

Output: 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Intern Med publish 169:610–618?. ### Response: 2018.


Instruction: What year was Kidney International published?

Output: 2021

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was Kidney International published?. ### Response: 2021.


Instruction: What did the writing committee consider assessing rates of after PCI?

Output: blood transfusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the writing committee consider assessing rates of after PCI?. ### Response: blood transfusion.


Instruction: Why was the measure not included as a measure?

Output: it is currently challenging to adequately account for allthe factors related to the decision to transfuse patients afterPCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the measure not included as a measure?. ### Response: it is currently challenging to adequately account for allthe factors related to the decision to transfuse patients afterPCI.


Instruction: The writing committee felt that it is currently challenging to adequately account for all factors related to what?

Output: the decision to transfuse patients afterPCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The writing committee felt that it is currently challenging to adequately account for all factors related to what?. ### Response: the decision to transfuse patients afterPCI.


Instruction: What are some patients after PCI related to?

Output: theprocedure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some patients after PCI related to?. ### Response: theprocedure.


Instruction: What is the name of the journal that describes emergency coronary artery bypass surgery?

Output: JACC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that describes emergency coronary artery bypass surgery?. ### Response: JACC.


Instruction: When was the 2013 PCI Performance Measure published?

Output: February 25, 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the 2013 PCI Performance Measure published?. ### Response: February 25, 2014.


Instruction: What may be considered to reduce the risk of recurrent embolism if there is no evidence of intracranial hemorrhage or extensive neurologi-cal damage?

Output: biotics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered to reduce the risk of recurrent embolism if there is no evidence of intracranial hemorrhage or extensive neurologi-cal damage?. ### Response: biotics.


Instruction: What can be considered in patients with ischemic stroke or TIA and IE?

Output: early valve surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be considered in patients with ischemic stroke or TIA and IE?. ### Response: early valve surgery.


Instruction: What may be considered in patients with no evidence of intracranial hemorrhage or extensive neurological damage?

Output: early valve surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered in patients with no evidence of intracranial hemorrhage or extensive neurological damage?. ### Response: early valve surgery.


Instruction: For patients with IE and major ischemic stroke, delaying valve surgery for at least 4 weeks is considered what?

Output: hemodynamically stable

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For patients with IE and major ischemic stroke, delaying valve surgery for at least 4 weeks is considered what?. ### Response: hemodynamically stable.


Instruction: How long may be considered for patients with IE and major ischemic stroke or intracranial hemorrhage if the patient is hemodynamically stable?

Output: surgery for at least 4 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long may be considered for patients with IE and major ischemic stroke or intracranial hemorrhage if the patient is hemodynamically stable?. ### Response: surgery for at least 4 weeks.


Instruction: What does dabigatran cause in patients with mechanical heart valves?

Output: harm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does dabigatran cause in patients with mechanical heart valves?. ### Response: harm.


Instruction: What does dabigatran cause to heart valves?

Output: harm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does dabigatran cause to heart valves?. ### Response: harm.


Instruction: What is the process used to reach consensus in both cases?

Output: the same

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the process used to reach consensus in both cases?. ### Response: the same.


Instruction: What is valvular AF?

Output: moderate to severe mitral stenosis or a mechanical heart valve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is valvular AF?. ### Response: moderate to severe mitral stenosis or a mechanical heart valve.


Instruction: What is the term for a mechanical heart valve?

Output: valvular AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for a mechanical heart valve?. ### Response: valvular AF.


Instruction: Antiplatelet therapy is still recommended over what?

Output: warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Antiplatelet therapy is still recommended over what?. ### Response: warfarin.


Instruction: Antiplatelet therapy continues to be recommended over warfarin in patients with what type of disease?

Output: VHD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Antiplatelet therapy continues to be recommended over warfarin in patients with what type of disease?. ### Response: VHD.


Instruction: What type of valve is influenced by the type of therapy?

Output: bioprosthetic versus mechanical

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of valve is influenced by the type of therapy?. ### Response: bioprosthetic versus mechanical.


Instruction: What is influenced by the type of valve?

Output: antithrombotic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is influenced by the type of valve?. ### Response: antithrombotic therapy.


Instruction: Indications and timing for surgical interventions in patients with IE and stroke or TIA depend on multiple factors?

Output: recurrent events while on antibiotic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Indications and timing for surgical interventions in patients with IE and stroke or TIA depend on multiple factors?. ### Response: recurrent events while on antibiotic therapy.


Instruction: What depend on multiple factors?

Output: Indications and timing for surgical interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What depend on multiple factors?. ### Response: Indications and timing for surgical interventions.


Instruction: What is the recommended antithrombotic regimen in patients with history of ischemic stroke?

Output: Figure 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommended antithrombotic regimen in patients with history of ischemic stroke?. ### Response: Figure 3.


Instruction: What is highly prevalent in patients with VHD?

Output: AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is highly prevalent in patients with VHD?. ### Response: AF.


Instruction: What is one of the most important risk fac-tors for ischemic stroke and TIA?

Output: AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the most important risk fac-tors for ischemic stroke and TIA?. ### Response: AF.


Instruction: What is crucial in the selection of the optimal oral anticoagula-tion regimen?

Output: the distinction between valvular and nonvalvular AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is crucial in the selection of the optimal oral anticoagula-tion regimen?. ### Response: the distinction between valvular and nonvalvular AF.


Instruction: What refers to AF in the context of moderate to severe mitral stenosis or the presence of any mechanical heart valve?

Output: valvular

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What refers to AF in the context of moderate to severe mitral stenosis or the presence of any mechanical heart valve?. ### Response: valvular.


Instruction: What does the term nonvalvular mean?

Output: nonvalvular AF is crucial because it has important implications in the selection of the optimal oral anticoagula-tion regimen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the term nonvalvular mean?. ### Response: nonvalvular AF is crucial because it has important implications in the selection of the optimal oral anticoagula-tion regimen.


Instruction: What is considered a contraindication to all NOACs on the basis of the outcomes of the RE-ALIGN trial?

Output: the presence of a mechanical heart valve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is considered a contraindication to all NOACs on the basis of the outcomes of the RE-ALIGN trial?. ### Response: the presence of a mechanical heart valve.


Instruction: What type of valve is considered a contraindication to all NOACs?

Output: mechanical heart valve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of valve is considered a contraindication to all NOACs?. ### Response: mechanical heart valve.


Instruction: What is a major advance in therapeutic safety when compared with other types of anticoagulants?

Output: NOACs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a major advance in therapeutic safety when compared with other types of anticoagulants?. ### Response: NOACs.


Instruction: NOACs represent an advance in therapeutic safety when compared with what other drug?

Output: warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: NOACs represent an advance in therapeutic safety when compared with what other drug?. ### Response: warfarin.


Instruction: What does NOAC reduce intracranial bleeding as compared to warfarin?

Output: S4.2.2.2-1–S4.2.2.2-5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does NOAC reduce intracranial bleeding as compared to warfarin?. ### Response: S4.2.2.2-1–S4.2.2.2-5.


Instruction: The NOAC AF trials demonstrated that NOAC are superior to what drug in preventing stroke?

Output: warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The NOAC AF trials demonstrated that NOAC are superior to what drug in preventing stroke?. ### Response: warfarin.


Instruction: What is intracranial bleeding compared to with warfarin?

Output: NOACs reduce

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is intracranial bleeding compared to with warfarin?. ### Response: NOACs reduce.


Instruction: No direct RCT data are available.

Output: Anticoagulant Options

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No direct RCT data are available.. ### Response: Anticoagulant Options.


Instruction: What are emerging from meta-analyses of the original NOAC clinical trials?

Output: limited data comparing individual NOACs to one another

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are emerging from meta-analyses of the original NOAC clinical trials?. ### Response: limited data comparing individual NOACs to one another.


Instruction: What is an example of a specific NOAC?

Output: apixaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a specific NOAC?. ### Response: apixaban.


Instruction: What is apixaban?

Output: Specific NOACs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is apixaban?. ### Response: Specific NOACs.


Instruction: What is the risk of bleeding for rivaroxaban comparable to?

Output: warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of bleeding for rivaroxaban comparable to?. ### Response: warfarin.


Instruction: In other studies, uninterrupted dabi-gatran had a more favorable outcome than what drug?

Output: warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In other studies, uninterrupted dabi-gatran had a more favorable outcome than what drug?. ### Response: warfarin.


Instruction: What is the RE-CIRCUIT Trial?

Output: Uninterrupted Dabigatran Etexilate in Comparison to Uninterrupted Warfarin in Pulmonary Vein Ablation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the RE-CIRCUIT Trial?. ### Response: Uninterrupted Dabigatran Etexilate in Comparison to Uninterrupted Warfarin in Pulmonary Vein Ablation.


Instruction: What may NOACs be associated with lower risks of adverse renal outcomes than warfarin?

Output: dabigatran and rivaroxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may NOACs be associated with lower risks of adverse renal outcomes than warfarin?. ### Response: dabigatran and rivaroxaban.


Instruction: What did dabigatran have a lower risk of in older adults with AF receiving anticoagulation than warfarin?

Output: osteoporotic fracture

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did dabigatran have a lower risk of in older adults with AF receiving anticoagulation than warfarin?. ### Response: osteoporotic fracture.


Instruction: What is emerging data on drug interactions with NOACs?

Output: meta-analyses of the original NOAC clinical trialsS4.2.2.2-6 and registries and patient databases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is emerging data on drug interactions with NOACs?. ### Response: meta-analyses of the original NOAC clinical trialsS4.2.2.2-6 and registries and patient databases.


Instruction: What are some of the factors that should be considered when designing a trial?

Output: absence of control groups, incomplete laboratory and histori-cal data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the factors that should be considered when designing a trial?. ### Response: absence of control groups, incomplete laboratory and histori-cal data.


Instruction: What is missing data for some drugs?

Output: edoxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is missing data for some drugs?. ### Response: edoxaban.


Instruction: How do some drugs in the United States differ from those in Europe?

Output: varying NOAC drug doses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do some drugs in the United States differ from those in Europe?. ### Response: varying NOAC drug doses.


Instruction: What is needed for further evaluation of comparative bleeding risk and effectiveness?

Output: Head-to-head prospective RCT data for NO-ACs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed for further evaluation of comparative bleeding risk and effectiveness?. ### Response: Head-to-head prospective RCT data for NO-ACs.


Instruction: What is now available to measure NOAC serum levels?

Output: Commercial assays

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is now available to measure NOAC serum levels?. ### Response: Commercial assays.


Instruction: Reference ranges derived from published literature are not well cor-related with what?

Output: safety, efficacy, and clinical outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Reference ranges derived from published literature are not well cor-related with what?. ### Response: safety, efficacy, and clinical outcomes.


Instruction: What is not well cor -related with safety, efficacy, and clinical outcomes?

Output: reference ranges derived from published literature

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not well cor -related with safety, efficacy, and clinical outcomes?. ### Response: reference ranges derived from published literature.


Instruction: Measurement of drug levels in patients undergoing urgent surgical procedures might include what?

Output: heart valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Measurement of drug levels in patients undergoing urgent surgical procedures might include what?. ### Response: heart valves.


Instruction: What does isradipine(Lomir) do after kidney transplantation?

Output: better renal function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does isradipine(Lomir) do after kidney transplantation?. ### Response: better renal function.


Instruction: What is the effect of diltiazem on acute kidney failure?

Output: Protective

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of diltiazem on acute kidney failure?. ### Response: Protective.


Instruction: What is the calciumantagonist of diltiazem used for?

Output: acute kidney failure following kidneytransplantation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the calciumantagonist of diltiazem used for?. ### Response: acute kidney failure following kidneytransplantation.


Instruction: What was the result of a prospective randomized study?

Output: Protective effect of the calciumantagonist diltiazem on acute kidney failure following kidneytransplantation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the result of a prospective randomized study?. ### Response: Protective effect of the calciumantagonist diltiazem on acute kidney failure following kidneytransplantation.


Instruction: When was the 111th DtschMed Wochenschr published?

Output: 1986

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the 111th DtschMed Wochenschr published?. ### Response: 1986.


Instruction: What is nifedipine used for in kidney transplant recipients?

Output: early renal allograft function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is nifedipine used for in kidney transplant recipients?. ### Response: early renal allograft function.


Instruction: What is angiotensin II blockade?

Output: inkidney transplant recipients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is angiotensin II blockade?. ### Response: inkidney transplant recipients.


Instruction: How does angiotensin II blockade in kidney transplant recipients?

Output: renin-angiotensin system blockade

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does angiotensin II blockade in kidney transplant recipients?. ### Response: renin-angiotensin system blockade.


Instruction: How does candesartan improve bloodpressure control and reduce proteinuria?

Output: results from SECRET

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does candesartan improve bloodpressure control and reduce proteinuria?. ### Response: results from SECRET.


Instruction: When did Salzberg DJ, Karadsheh FF, Haririan A, et al. publish?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Salzberg DJ, Karadsheh FF, Haririan A, et al. publish?. ### Response: 2010.


Instruction: What is a potential randomized trial of calcium channel blockade and preservation of renal graft function in cyclosporine-treatedrecipients?

Output: placebo-controlled 2-year study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a potential randomized trial of calcium channel blockade and preservation of renal graft function in cyclosporine-treatedrecipients?. ### Response: placebo-controlled 2-year study.


Instruction: What is the name of the prospective randomized placebo-controlled 2-year study?

Output: Calcium channel blockadeand preservation of renal graft function in cyclosporine-treatedrecipients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective randomized placebo-controlled 2-year study?. ### Response: Calcium channel blockadeand preservation of renal graft function in cyclosporine-treatedrecipients.


Instruction: What is cyclosporine used for?

Output: preservation of renal graft function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is cyclosporine used for?. ### Response: preservation of renal graft function.


Instruction: How long did the study last?

Output: 2-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the study last?. ### Response: 2-year.


Instruction: What is the name of the kidney transplantation that causes hypertension?

Output: renaltransplantation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the kidney transplantation that causes hypertension?. ### Response: renaltransplantation.


Instruction: What is another name for converting enzyme blockade?

Output: Calcium channel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for converting enzyme blockade?. ### Response: Calcium channel.


Instruction: In what year did Nephrol Dial Transplant issue 14:384-388.334?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did Nephrol Dial Transplant issue 14:384-388.334?. ### Response: 1999.


Instruction: What is amlodipinein normotensive renal transplant recipients treated with?

Output: reduced dose of cyclosporine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is amlodipinein normotensive renal transplant recipients treated with?. ### Response: reduced dose of cyclosporine.


Instruction: What is the effect of nifedipine on renalhaemodynamics and urinary protein excretion in stable renaltransplant recipients?

Output: reduces proteinuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of nifedipine on renalhaemodynamics and urinary protein excretion in stable renaltransplant recipients?. ### Response: reduces proteinuria.


Instruction: What type of edema is associated with calcium channel blockers?

Output: Peripheral

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of edema is associated with calcium channel blockers?. ### Response: Peripheral.


Instruction: What is the incidence and withdrawal rate of calcium channel blocks?

Output: Peripheral edema

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the incidence and withdrawal rate of calcium channel blocks?. ### Response: Peripheral edema.


Instruction: When was the J Hypertens.29:1270 – 1280.336?

Output: 1995

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Hypertens.29:1270 – 1280.336?. ### Response: 1995.


Instruction: What is a UK general practice-basedcohort study?

Output: Adherence to guidelines forcreatinine and potassium monitoring and discontinuation followingrenin-angiotensin system blockade

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a UK general practice-basedcohort study?. ### Response: Adherence to guidelines forcreatinine and potassium monitoring and discontinuation followingrenin-angiotensin system blockade.


Instruction: What is the name of the randomized controlled trial?

Output: Amara AB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized controlled trial?. ### Response: Amara AB.


Instruction: What is being retired because it covers only one aspect of medication use and misses other aspects such as inappropriate use?

Output: QM-7 Inpatient Anticoagulant Dosing Protocol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is being retired because it covers only one aspect of medication use and misses other aspects such as inappropriate use?. ### Response: QM-7 Inpatient Anticoagulant Dosing Protocol.


Instruction: What is not a direct stand-alone Class I or III recommendation in the guidelines?

Output: QM-7 Inpatient Anticoagulant Dosing Protocol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not a direct stand-alone Class I or III recommendation in the guidelines?. ### Response: QM-7 Inpatient Anticoagulant Dosing Protocol.


Instruction: What does the QM-8 Inpatient Anticoagulant Error Tracking System cover only?

Output: limited aspects of medication use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the QM-8 Inpatient Anticoagulant Error Tracking System cover only?. ### Response: limited aspects of medication use.


Instruction: What is missing from this measure?

Output: patient reasons

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is missing from this measure?. ### Response: patient reasons.


Instruction: Why is this measure being retired?

Output: because it covers only one aspect of medication use and misses other aspects such as inappropriate use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is this measure being retired?. ### Response: because it covers only one aspect of medication use and misses other aspects such as inappropriate use.


Instruction: AMI indicates acute myocardial infarction.

Output: QM-7 Inpatient Anticoagulant Dosing Protocol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: AMI indicates acute myocardial infarction.. ### Response: QM-7 Inpatient Anticoagulant Dosing Protocol.


Instruction: LDL, low-density lipoprotein, what is NSTEMI?

Output: non–ST-elevation myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: LDL, low-density lipoprotein, what is NSTEMI?. ### Response: non–ST-elevation myocardial infarction.


Instruction: PM, performance measure, and QM are what?

Output: quality measure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: PM, performance measure, and QM are what?. ### Response: quality measure.


Instruction: What is being revised to reflect the 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults?

Output: PM-4 Inpatient Statin for AMI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is being revised to reflect the 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults?. ### Response: PM-4 Inpatient Statin for AMI.


Instruction: Who recommended statin use for all patients with established atherosclerotic cardiovascular disease?

Output: ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who recommended statin use for all patients with established atherosclerotic cardiovascular disease?. ### Response: ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults.


Instruction: Which measure is being revised from "Evaluation of Left Ventricular Systolic Function"?

Output: PM- 5 Inpatient Evaluation of LVEF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which measure is being revised from "Evaluation of Left Ventricular Systolic Function"?. ### Response: PM- 5 Inpatient Evaluation of LVEF.


Instruction: What are the treatment recommendations regarding the use of guideline-directed medication therapies based on?

Output: LVEF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the treatment recommendations regarding the use of guideline-directed medication therapies based on?. ### Response: LVEF.


Instruction: What is the 2013 ACCF/AHA STEMI guideline12 explicitly recommended measuring?

Output: LVEF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2013 ACCF/AHA STEMI guideline12 explicitly recommended measuring?. ### Response: LVEF.


Instruction: The 2014 AHA/ACC NSTE-ACS guidelines11 have what?

Output: medication recommendations based on knowledge of the ejection fraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The 2014 AHA/ACC NSTE-ACS guidelines11 have what?. ### Response: medication recommendations based on knowledge of the ejection fraction.


Instruction: What is based on knowledge of the ejection fraction?

Output: medication recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is based on knowledge of the ejection fraction?. ### Response: medication recommendations.


Instruction: What measure is being adapted from the AACVPR/ACCF/AHA 2010 Update: Performance Measures on Cardiac Rehabilitation?

Output: Inpatient Cardiac Rehabilitation Referral

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What measure is being adapted from the AACVPR/ACCF/AHA 2010 Update: Performance Measures on Cardiac Rehabilitation?. ### Response: Inpatient Cardiac Rehabilitation Referral.


Instruction: What was removed from the 2010 measurement set?

Output: patient reasons

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was removed from the 2010 measurement set?. ### Response: patient reasons.


Instruction: What does not constitute a justifiable reason for a clinician not offering a referral to a patient?

Output: patient refusal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not constitute a justifiable reason for a clinician not offering a referral to a patient?. ### Response: patient refusal.


Instruction: What is consistent with HIPAA confidentiality?

Output: If documentation in the medical record exists noting that the provider has informed and discussed referral to cardiac rehabilitation/secondary prevention program with the patient, but that the patient refuses a referral, then the healthcare provider would not be expected to send communication about the patient to the cardiac rehabilitation/secondary prevention program. This is consistent with HIPAA confidentiality regulations and shared decision making

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is consistent with HIPAA confidentiality?. ### Response: If documentation in the medical record exists noting that the provider has informed and discussed referral to cardiac rehabilitation/secondary prevention program with the patient, but that the patient refuses a referral, then the healthcare provider would not be expected to send communication about the patient to the cardiac rehabilitation/secondary prevention program. This is consistent with HIPAA confidentiality regulations and shared decision making.


Instruction: What would the healthcare provider not be expected to do if the patient refuses a referral?

Output: send communication about the patient to the cardiac rehabilitation/secondary prevention program

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would the healthcare provider not be expected to do if the patient refuses a referral?. ### Response: send communication about the patient to the cardiac rehabilitation/secondary prevention program.


Instruction: What is the purpose of a P2Y12 Receptor Inhibitor program?

Output: preventing unjust penalization of the provider

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of a P2Y12 Receptor Inhibitor program?. ### Response: preventing unjust penalization of the provider.


Instruction: What are the requirements for a cardiac rehabilitation/secondary prevention program that are consistent with HIPAA?

Output: confidentiality regulations and shared decision making

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the requirements for a cardiac rehabilitation/secondary prevention program that are consistent with HIPAA?. ### Response: confidentiality regulations and shared decision making.


Instruction: Who published the 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary?

Output: Arnett et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary?. ### Response: Arnett et al.


Instruction: Whose risk is sufficiently high should medications to reduce ASCVD risk be considered as part of a shared decision-making process?

Output: person

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Whose risk is sufficiently high should medications to reduce ASCVD risk be considered as part of a shared decision-making process?. ### Response: person.


Instruction: How should clinicians and individuals focus on living a healthy lifestyle?

Output: by referring to these evidence-based recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How should clinicians and individuals focus on living a healthy lifestyle?. ### Response: by referring to these evidence-based recommendations.


Instruction: What is the aim of this guideline?

Output: to de-sign a comprehensive yet succinct compilation of practi-cal guidance for the primary prevention of ASCVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the aim of this guideline?. ### Response: to de-sign a comprehensive yet succinct compilation of practi-cal guidance for the primary prevention of ASCVD.


Instruction: What is the aim of the AHA's guideline?

Output: to de-sign a comprehensive yet succinct compilation of practi-cal guidance for the primary prevention of ASCVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the aim of the AHA's guideline?. ### Response: to de-sign a comprehensive yet succinct compilation of practi-cal guidance for the primary prevention of ASCVD.


Instruction: What are the recommen-dations listed in the guideline evidence based and supported by?

Output: an extensive evidence review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the recommen-dations listed in the guideline evidence based and supported by?. ### Response: an extensive evidence review.


Instruction: How was the search conducted for literature derived from research involving human sub-jects?

Output: published in English, and indexed in Ovid MED-LINE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the search conducted for literature derived from research involving human sub-jects?. ### Response: published in English, and indexed in Ovid MED-LINE.


Instruction: What is the name of the national institute for health and care excellence?

Output: NICE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the national institute for health and care excellence?. ### Response: NICE.


Instruction: What are RCTs?

Output: Randomized controlled trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are RCTs?. ### Response: Randomized controlled trials.


Instruction: What are meta-analyses and large, US-based, high-quality cohort studies called?

Output: Randomized controlled trials (RCTs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are meta-analyses and large, US-based, high-quality cohort studies called?. ### Response: Randomized controlled trials (RCTs.


Instruction: How many topic areas were evaluated for their content on the prevention of ASCVD outcomes?

Output: 9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many topic areas were evaluated for their content on the prevention of ASCVD outcomes?. ### Response: 9.


Instruction: What type of diabetes is T2DM?

Output: diabetes mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diabetes is T2DM?. ### Response: diabetes mellitus.


Instruction: What is another name for diabetes mellitus?

Output: T2DM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for diabetes mellitus?. ### Response: T2DM.


Instruction: What are some of the other things that have been assessed in the ACC/AHA guideline?

Output: Previous ACC/AHA guidelines, as well as US Preventive Services Task Force (USPSTF) reviews

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the other things that have been assessed in the ACC/AHA guideline?. ### Response: Previous ACC/AHA guidelines, as well as US Preventive Services Task Force (USPSTF) reviews.


Instruction: The Online Data Supplement summarizes the evidence used to formulate what?

Output: recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The Online Data Supplement summarizes the evidence used to formulate what?. ### Response: recommendations.


Instruction: Who served as the document manager for this guideline?

Output: Avalere Health

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who served as the document manager for this guideline?. ### Response: Avalere Health.


Instruction: What did Avalere Health facilitate?

Output: the deliberations of the writing committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Avalere Health facilitate?. ### Response: the deliberations of the writing committee.


Instruction: What role did Avalere hold as a document manager?

Output: facilitated the deliberations of the writing committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What role did Avalere hold as a document manager?. ### Response: facilitated the deliberations of the writing committee.


Instruction: What was the modified Delphi process used for?

Output: establishing the Class of Recommendation and the Level of Evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the modified Delphi process used for?. ### Response: establishing the Class of Recommendation and the Level of Evidence.


Instruction: Who was an independent health data and epidemiology expert?

Output: Lee Ann Prebil

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was an independent health data and epidemiology expert?. ### Response: Lee Ann Prebil.


Instruction: Who conducted a systematic evidence review for the key topic of exercise and physical activity?

Output: Lee Ann Prebil

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who conducted a systematic evidence review for the key topic of exercise and physical activity?. ### Response: Lee Ann Prebil.


Instruction: Who conducted targeted literature searches to support the document’s discussion of patient-centered approaches?

Output: Lee Ann Prebil

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who conducted targeted literature searches to support the document’s discussion of patient-centered approaches?. ### Response: Lee Ann Prebil.


Instruction: Who published the 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease?

Output: Arnett et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease?. ### Response: Arnett et al.


Instruction: What is the name of the guideline published by the American College of Cardiology and the American Heart Association?

Output: Guideline on the Primary Prevention of Cardiovascular DiseaseCirculation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the guideline published by the American College of Cardiology and the American Heart Association?. ### Response: Guideline on the Primary Prevention of Cardiovascular DiseaseCirculation.


Instruction: What is the name of the electronic nicotine delivery system?

Output: *END

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the electronic nicotine delivery system?. ### Response: *END.


Instruction: When was the rapid review conducted by the Evidence-based Practice Center completed?

Output: in the limited timeframe provided

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the rapid review conducted by the Evidence-based Practice Center completed?. ### Response: in the limited timeframe provided.


Instruction: What was built on existing systematic reviews conducted on behalf of the USPSTF?

Output: The rapid review conducted by the Evidence-based Practice Center to complete this literature search

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was built on existing systematic reviews conducted on behalf of the USPSTF?. ### Response: The rapid review conducted by the Evidence-based Practice Center to complete this literature search.


Instruction: Since the 2017 review, what has been searched since the 2018 review?

Output: Obesity and Weight Loss

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Since the 2017 review, what has been searched since the 2018 review?. ### Response: Obesity and Weight Loss.


Instruction: Since the 2015 review3exp Diabetes Mellitus, Type 2/ impaired fasting glucosePrediabetic State/ impaired glucose toleranceGlucose Intolerance/ IfgPrimary Prevention/ Igtpredibetes*type 2 diabet*DMAppendix 1?

Output: coronaryheartmyocardial infarctionMICVDCHDcerebrovascularstrokemicrovascularmortalityprevent*Type 2 Diabetes MellitusSearch since the 2015 review3exp Diabetes Mellitus, Type 2/ impaired fasting glucosePrediabetic State/ impaired glucose toleranceGlucose Intolerance/ IfgPrimary Prevention/ Igtprediabetes*type 2 diabet*DMAppendix 1.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Since the 2015 review3exp Diabetes Mellitus, Type 2/ impaired fasting glucosePrediabetic State/ impaired glucose toleranceGlucose Intolerance/ IfgPrimary Prevention/ Igtpredibetes*type 2 diabet*DMAppendix 1?. ### Response: coronaryheartmyocardial infarctionMICVDCHDcerebrovascularstrokemicrovascularmortalityprevent*Type 2 Diabetes MellitusSearch since the 2015 review3exp Diabetes Mellitus, Type 2/ impaired fasting glucosePrediabetic State/ impaired glucose toleranceGlucose Intolerance/ IfgPrimary Prevention/ Igtprediabetes*type 2 diabet*DMAppendix 1..


Instruction: What is the name of the website that contains the (MeSH) Terms Key Words?

Output: ahajournals.org

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the website that contains the (MeSH) Terms Key Words?. ### Response: ahajournals.org.


Instruction: On what date was the document downloaded?

Output: May 1, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On what date was the document downloaded?. ### Response: May 1, 2023.


Instruction: How many times will the document be available for download?

Output: May 1, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many times will the document be available for download?. ### Response: May 1, 2023.


Instruction: What are reviewers required to complete and submit?

Output: Questionnaire

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are reviewers required to complete and submit?. ### Response: Questionnaire.


Instruction: What is a relationship considered to be if a person receives $ 10 000 or more during a 12-month period?

Output: significant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a relationship considered to be if a person receives $ 10 000 or more during a 12-month period?. ### Response: significant.


Instruction: How much of the voting stock or share of the entity does the person own?

Output: 5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the voting stock or share of the entity does the person own?. ### Response: 5%.


Instruction: What is a relationship considered to be if it is less than "significant"?

Output: modest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a relationship considered to be if it is less than "significant"?. ### Response: modest.


Instruction: Circulation January 26, what is the date of publication of the circular?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation January 26, what is the date of publication of the circular?. ### Response: 2010.


Instruction: What is the meaning of the word “significant” in the preceding de finition?

Output: less than “significant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the meaning of the word “significant” in the preceding de finition?. ### Response: less than “significant.


Instruction: When was this publication released?

Output: May 2, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this publication released?. ### Response: May 2, 2023.


Instruction: What is the name of the CT-angiography spot sign?

Output: PREDICT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the CT-angiography spot sign?. ### Response: PREDICT.


Instruction: What is PREDICT?

Output: Sunnybrook ICH CTA Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PREDICT?. ### Response: Sunnybrook ICH CTA Study Group.


Instruction: When did the Lancet Neurol. 2012 issue?

Output: 11:307–314

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Lancet Neurol. 2012 issue?. ### Response: 11:307–314.


Instruction: What predicts hematoma expansion in patients with delayed presentation after intracerebral hemorrhage?

Output: CTA spot sign

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What predicts hematoma expansion in patients with delayed presentation after intracerebral hemorrhage?. ### Response: CTA spot sign.


Instruction: What does CTA spot sign predict?

Output: hematoma expansion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CTA spot sign predict?. ### Response: hematoma expansion.


Instruction: What is useful for identifying patients at risk for hematoma enlargement?

Output: CTA spot sign

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is useful for identifying patients at risk for hematoma enlargement?. ### Response: CTA spot sign.


Instruction: What are the Spot signs in intracerebral hemorrhage useful for?

Output: identifying patients at risk for hematoma enlargement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Spot signs in intracerebral hemorrhage useful for?. ### Response: identifying patients at risk for hematoma enlargement.


Instruction: What is the most common spot sign number?

Output: A1546

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common spot sign number?. ### Response: A1546.


Instruction: What is the most important spot sign char -acteristic for predicting hematoma expansion using first-pass computed tomography angiography?

Output: Spot sign number

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most important spot sign char -acteristic for predicting hematoma expansion using first-pass computed tomography angiography?. ### Response: Spot sign number.


Instruction: What year did Stroke.44:972-977. doi: 10.1161/STROKEAHA.111.000410?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Stroke.44:972-977. doi: 10.1161/STROKEAHA.111.000410?. ### Response: 2013.


Instruction: What identify patients at highest risk of in-hospital mortality and poor outcome among survivors?

Output: The spot sign score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What identify patients at highest risk of in-hospital mortality and poor outcome among survivors?. ### Response: The spot sign score.


Instruction: What is the spot sign score in primary intracerebral hemor -rhage?

Output: highest risk of in-hospital mortality and poor outcome among survivors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the spot sign score in primary intracerebral hemor -rhage?. ### Response: highest risk of in-hospital mortality and poor outcome among survivors.


Instruction: What is the name of the study that improved diagnostic yield and cost effectiveness in the initial evaluation of spontaneous nonsubarach-noid intracerebral hemorrhage?

Output: Computed tomography angiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that improved diagnostic yield and cost effectiveness in the initial evaluation of spontaneous nonsubarach-noid intracerebral hemorrhage?. ### Response: Computed tomography angiography.


Instruction: What is a term for computed tomography angiography?

Output: spot sign

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a term for computed tomography angiography?. ### Response: spot sign.


Instruction: What is the name of the multidetector CT angiog-raphy used in the evaluation of spontaneous intraparenchymal cerebral hemor -rhage?

Output: PREDICT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multidetector CT angiog-raphy used in the evaluation of spontaneous intraparenchymal cerebral hemor -rhage?. ### Response: PREDICT.


Instruction: What is AJNR Am J Neuroradiol 2009.30:1213–1221. doi: 10.3174/ajnr.A1546?

Output: Diagnostic accuracy and yield of multidetector CT angiog-raphy in the evaluation of spontaneous intraparenchymal cerebral hemor -rhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is AJNR Am J Neuroradiol 2009.30:1213–1221. doi: 10.3174/ajnr.A1546?. ### Response: Diagnostic accuracy and yield of multidetector CT angiog-raphy in the evaluation of spontaneous intraparenchymal cerebral hemor -rhage.


Instruction: What is the name of the CT angiography “spot sign” in patients with secondary intracerebral hemorrhage?

Output: PREDICT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the CT angiography “spot sign” in patients with secondary intracerebral hemorrhage?. ### Response: PREDICT.


Instruction: When was the last time a patient had a CT scan done?

Output: 53

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last time a patient had a CT scan done?. ### Response: 53.


Instruction: How many patients had CT scans done in 2008?

Output: 59

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had CT scans done in 2008?. ### Response: 59.


Instruction: What is MR angiog-raphy of moyamoya disease before and after encephaloduroarterior-venous malformation?

Output: Spot sign number

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is MR angiog-raphy of moyamoya disease before and after encephaloduroarterior-venous malformation?. ### Response: Spot sign number.


Instruction: Who published the 2019 Guidelines for Management of AIS e3772?

Output: Powers et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2019 Guidelines for Management of AIS e3772?. ### Response: Powers et al.


Instruction: How long did the treatment with aspirin and clopidogrel last?

Output: 21 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the treatment with aspirin and clopidogrel last?. ### Response: 21 days.


Instruction: What was the NIHSS score 3?

Output: ≤ 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the NIHSS score 3?. ### Response: ≤ 3.


Instruction: How long after symptom onset is dual antiplatelet therapy effective in reducing recurrent ischemic stroke for a period of up to 90 days?

Output: ≈10 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after symptom onset is dual antiplatelet therapy effective in reducing recurrent ischemic stroke for a period of up to 90 days?. ### Response: ≈10 days.


Instruction: How many independent multicenter, randomized, double-blind, placebo-controlled trials have established the efficacy of short-term dual anti platelet therapy?

Output: Two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many independent multicenter, randomized, double-blind, placebo-controlled trials have established the efficacy of short-term dual anti platelet therapy?. ### Response: Two.


Instruction: What is short-term dual antiplatelet therapy to prevent in patients with minor stroke or high-risk TIA?

Output: recurrent ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is short-term dual antiplatelet therapy to prevent in patients with minor stroke or high-risk TIA?. ### Response: recurrent ischemic stroke.


Instruction: What was the name of the CHANCE trial?

Output: Clopidogrel in High Risk Patients With Acute Nondisabling Cerebrovascular Events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the CHANCE trial?. ### Response: Clopidogrel in High Risk Patients With Acute Nondisabling Cerebrovascular Events.


Instruction: In what country was this trial conducted?

Output: China

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what country was this trial conducted?. ### Response: China.


Instruction: What was the initial dose of clopidogrel?

Output: 300 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the initial dose of clopidogrel?. ### Response: 300 mg.


Instruction: How long was the dosing regimen for dual antiplatelet therapy?

Output: ≈10 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the dosing regimen for dual antiplatelet therapy?. ### Response: ≈10 days.


Instruction: What is the NIHSS score 3?

Output: ≤ 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the NIHSS score 3?. ### Response: ≤ 3.


Instruction: What was the primary outcome of the study?

Output: dual antiplatelet therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary outcome of the study?. ### Response: dual antiplatelet therapy.


Instruction: How long did it take for aspirin to work?

Output: 21 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for aspirin to work?. ### Response: 21 days.


Instruction: What did the participants receive on day 1?

Output: open-label aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the participants receive on day 1?. ### Response: open-label aspirin.


Instruction: What was the primary outcome of recurrent stroke at 90 days?

Output: dual antiplatelet therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary outcome of recurrent stroke at 90 days?. ### Response: dual antiplatelet therapy.


Instruction: What is the hazard ratio (HR) of dual antiplatelet therapy?

Output: 0.68

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the hazard ratio (HR) of dual antiplatelet therapy?. ### Response: 0.68.


Instruction: Post hoc analysis found a small but measurable reduction in what?

Output: poor functional outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Post hoc analysis found a small but measurable reduction in what?. ### Response: poor functional outcome.


Instruction: What was the measurable reduction in poor functional outcome on dual antiplatelet therapy compared with aspirin alone?

Output: absolute RR, 1.7%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the measurable reduction in poor functional outcome on dual antiplatelet therapy compared with aspirin alone?. ### Response: absolute RR, 1.7%.


Instruction: What did a post hoc time-course analysis show that the benefit in reducing recurrent ischemic stroke compared to the risk of bleeding dissipated?

Output: ≈10 days of treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a post hoc time-course analysis show that the benefit in reducing recurrent ischemic stroke compared to the risk of bleeding dissipated?. ### Response: ≈10 days of treatment.


Instruction: After how many days of treatment did the risk of bleeding on dual antiplatelet therapy dissipate?

Output: ≈10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: After how many days of treatment did the risk of bleeding on dual antiplatelet therapy dissipate?. ### Response: ≈10.


Instruction: A report of 1-year outcomes found a durable treatment effect, but what was only significantly beneficial in the first 90 days?

Output: HR for secondary stroke prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A report of 1-year outcomes found a durable treatment effect, but what was only significantly beneficial in the first 90 days?. ### Response: HR for secondary stroke prevention.


Instruction: Subgroup analyses found no benefit of what?

Output: clopidogrel plus aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Subgroup analyses found no benefit of what?. ### Response: clopidogrel plus aspirin.


Instruction: How long did clopidogrel plus aspirin not benefit carriers of a CYP2C19 loss-of-function allele214?

Output: 90 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did clopidogrel plus aspirin not benefit carriers of a CYP2C19 loss-of-function allele214?. ### Response: 90 days.


Instruction: What was the POINT trial?

Output: Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the POINT trial?. ### Response: Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke.


Instruction: Where was the POINT trial conducted?

Output: North America, Europe, Australia, and New Zealand

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where was the POINT trial conducted?. ### Response: North America, Europe, Australia, and New Zealand.


Instruction: What percent of the participants were white?

Output: 75%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percent of the participants were white?. ### Response: 75%.


Instruction: Where were the majority of participants from the POTENT trial?

Output: United States

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where were the majority of participants from the POTENT trial?. ### Response: United States.


Instruction: What was the target enrollment population for CHANCE?

Output: N=5170

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the target enrollment population for CHANCE?. ### Response: N=5170.


Instruction: How many hours after symptom onset were patients randomized to clopidogrel plus aspirin?

Output: 24

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many hours after symptom onset were patients randomized to clopidogrel plus aspirin?. ### Response: 24.


Instruction: What is the gender influence on thediagnostic accuracy of 64-slice multisplice computed tomographycoronary angiography for detection of obstructive coronary arterydisease?

Output: Sex differences in mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the gender influence on thediagnostic accuracy of 64-slice multisplice computed tomographycoronary angiography for detection of obstructive coronary arterydisease?. ### Response: Sex differences in mortality.


Instruction: What is Motoyama S, Sarai M, Harigaya H, et al?

Output: Kondo T

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Motoyama S, Sarai M, Harigaya H, et al?. ### Response: Kondo T.


Instruction: What are the characteristics of atherosclerotic plaques that result in acute coronary syndrome?

Output: Computed tomographicangiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the characteristics of atherosclerotic plaques that result in acute coronary syndrome?. ### Response: Computed tomographicangiography.


Instruction: What is the J Am Coll Cardiol. 2009;54:49–57.212?

Output: Computed tomographicangiography characteristics of atherosclerotic plaques subsequentlyresulting in acute coronary syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the J Am Coll Cardiol. 2009;54:49–57.212?. ### Response: Computed tomographicangiography characteristics of atherosclerotic plaques subsequentlyresulting in acute coronary syndrome.


Instruction: Who is the author of the exploratoryanalysis?

Output: Shaw LJ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of the exploratoryanalysis?. ### Response: Shaw LJ.


Instruction: What is exploratoryanalysis?

Output: Sex differences in mortality asso-ciated with computed tomographic angiographic measuremen ts ofobstructive and nonobstructive coronary artery disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is exploratoryanalysis?. ### Response: Sex differences in mortality asso-ciated with computed tomographic angiographic measuremen ts ofobstructive and nonobstructive coronary artery disease.


Instruction: What is the name of the study that investigated multislice computed tomo-graphic characteristics of coronary lesions in acute coronary syn-dromes?

Output: CONFIRM (Coronary CT Angiography Evaluation forClinical Outcomes: An International Multicenter) Registry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated multislice computed tomo-graphic characteristics of coronary lesions in acute coronary syn-dromes?. ### Response: CONFIRM (Coronary CT Angiography Evaluation forClinical Outcomes: An International Multicenter) Registry.


Instruction: What does CONFIRM stand for?

Output: Coronary CT Angiography Evaluation forClinical Outcomes: An International Multicenter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CONFIRM stand for?. ### Response: Coronary CT Angiography Evaluation forClinical Outcomes: An International Multicenter.


Instruction: What is the name of the registry that evaluates coronary CT angiography for clinical outcomes?

Output: CONFIRM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the registry that evaluates coronary CT angiography for clinical outcomes?. ### Response: CONFIRM.


Instruction: What is a marker of inducible regionalmyocardial hypoperfusion from severe coronary artery stenoses?

Output: coronary CT angiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a marker of inducible regionalmyocardial hypoperfusion from severe coronary artery stenoses?. ### Response: coronary CT angiography.


Instruction: What is the name of the prospective2-center study of 2,583 patients undergoing 64-detector row coronary computed tomography?

Output: Mortality risk in symptomaticpatients with nonobstructive coronary artery disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective2-center study of 2,583 patients undergoing 64-detector row coronary computed tomography?. ### Response: Mortality risk in symptomaticpatients with nonobstructive coronary artery disease.


Instruction: How many patients underwent 64-detector row coronarycomputed tomographic angiography?

Output: 2,583

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients underwent 64-detector row coronarycomputed tomographic angiography?. ### Response: 2,583.


Instruction: What did the prospective2-center study of 2,583 patients involve?

Output: 64-detector row coronarycomputed tomographic angiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the prospective2-center study of 2,583 patients involve?. ### Response: 64-detector row coronarycomputed tomographic angiography.


Instruction: When was the J Am Coll Cardiol 58:510–9.217 published?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol 58:510–9.217 published?. ### Response: 2011.


Instruction: What does the American College of Cardiology/American Heart Association expert consensus document?

Output: electron-beam computed tomography for the diagnosis andprognosis of coronary artery disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the American College of Cardiology/American Heart Association expert consensus document?. ### Response: electron-beam computed tomography for the diagnosis andprognosis of coronary artery disease.


Instruction: What does electron-beam computed tomography do for the diagnosis andprognosis of coronary artery disease?

Output: detection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does electron-beam computed tomography do for the diagnosis andprognosis of coronary artery disease?. ### Response: detection.


Instruction: When did J Am Coll Cardiol. 2000;32:326–40.219?

Output: 2000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J Am Coll Cardiol. 2000;32:326–40.219?. ### Response: 2000.


Instruction: What is the symptomaticstatus on the prevalence of obstructive coronary artery disease inpatients with zero calcium score?

Output: Influence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the symptomaticstatus on the prevalence of obstructive coronary artery disease inpatients with zero calcium score?. ### Response: Influence.


Instruction: Atherosclerosis. 2009;203:533–7.220.

Output: omaticstatus on the prevalence of obstructive coronary artery disease inpatients with zero calcium score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atherosclerosis. 2009;203:533–7.220.. ### Response: omaticstatus on the prevalence of obstructive coronary artery disease inpatients with zero calcium score.


Instruction: Cademartiri F, Maffei E, Palumbo A, et al. Diagnostic accuracy of computed tomography in patients with a zerocalcium score.

Output: 2010;20:81–7.221

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cademartiri F, Maffei E, Palumbo A, et al. Diagnostic accuracy of computed tomography in patients with a zerocalcium score.. ### Response: 2010;20:81–7.221.


Instruction: What is an effective filter before catheter angiography?

Output: Multislice spiral computed tomo-graphic angiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an effective filter before catheter angiography?. ### Response: Multislice spiral computed tomo-graphic angiography.


Instruction: What is a noninvasive eval-uation with multislice computed tomography in suspected ac ute?

Output: Sex differences in mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a noninvasive eval-uation with multislice computed tomography in suspected ac ute?. ### Response: Sex differences in mortality.


Instruction: Chronic Heart Failure Treating Heart Failure  NICE 2018 All rights reserved. Subject to Notice of rights.

Output: 978 -1-4731 -3093 -7 215 6.3.1.4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Chronic Heart Failure Treating Heart Failure  NICE 2018 All rights reserved. Subject to Notice of rights.. ### Response: 978 -1-4731 -3093 -7 215 6.3.1.4.


Instruction: ISBN: 978-1-4731 -3093 -7 215 6.3.1.4 Economic evidence Published literature No relevant health economic studies were identified.

Output: Chronic Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ISBN: 978-1-4731 -3093 -7 215 6.3.1.4 Economic evidence Published literature No relevant health economic studies were identified.. ### Response: Chronic Heart Failure.


Instruction: Where is the health economic study selection flow chart located?

Output: Appendix  D

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the health economic study selection flow chart located?. ### Response: Appendix  D.


Instruction: What is the unit cost of the revascularisation procedures shown in Table 72 below?

Output: Unit costs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the unit cost of the revascularisation procedures shown in Table 72 below?. ### Response: Unit costs.


Instruction: How is the cost of all-cause hospitalisation provided?

Output: £2,930

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the cost of all-cause hospitalisation provided?. ### Response: £2,930.


Instruction: Table 72: Cost of revascularisation procedures Procedure Code Average cost Source Coronary Artery Bypass Graft (without ventricular reconstruction) £17,714 NHS reference costs 2014/15242 Percutaneous Coronary Intervention

Output: £2,930

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Table 72: Cost of revascularisation procedures Procedure Code Average cost Source Coronary Artery Bypass Graft (without ventricular reconstruction) £17,714 NHS reference costs 2014/15242 Percutaneous Coronary Intervention. ### Response: £2,930.


Instruction: How much was the NHS reference cost for 2014/15242?

Output: 6.3.1.5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much was the NHS reference cost for 2014/15242?. ### Response: 6.3.1.5.


Instruction: What is the weighted cost using the activity for each of the included HRG codes?

Output: £4,928

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the weighted cost using the activity for each of the included HRG codes?. ### Response: £4,928.


Instruction: How many studies were reported in 14 publications?

Output: Two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were reported in 14 publications?. ### Response: Two.


Instruction: What was the total cost of all-cause hospitalisation?

Output: £2,930

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the total cost of all-cause hospitalisation?. ### Response: £2,930.


Instruction: How many studies were reported for inclusion in the review?

Output: Two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were reported for inclusion in the review?. ### Response: Two.


Instruction: How many publications reported clinical two studies?

Output: 14

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many publications reported clinical two studies?. ### Response: 14.


Instruction: What did the evidence compare with an invasive strategy?

Output: medical management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the evidence compare with an invasive strategy?. ### Response: medical management.


Instruction: How many studies compared CABG plus medical management with medical management alone?

Output: 212

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies compared CABG plus medical management with medical management alone?. ### Response: 212.


Instruction: What was the risk of bias and imprecision?

Output: wide confidence intervals around the effect estimate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk of bias and imprecision?. ### Response: wide confidence intervals around the effect estimate.


Instruction: Why was the single outcome downgraded?

Output: indirectness of the outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the single outcome downgraded?. ### Response: indirectness of the outcome.


Instruction: What was the outcome reported as?

Output: the number of people in NYHA class I at the specified follow -up point of 4.7 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome reported as?. ### Response: the number of people in NYHA class I at the specified follow -up point of 4.7 years.


Instruction: How many people were in NYHA class I at the specified follow-up point?

Output: 4.7 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were in NYHA class I at the specified follow-up point?. ### Response: 4.7 years.


Instruction: How long was the specified follow up point?

Output: 4.7 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the specified follow up point?. ### Response: 4.7 years.