Instruction: What is shown as A, B, C, or D?

Output: the quality of thesupporting evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is shown as A, B, C, or D?. ### Response: the quality of thesupporting evidence.


Instruction: What does the chain of logic consist of?

Output: declarative sentences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the chain of logic consist of?. ### Response: declarative sentences.


Instruction: What is the recommended BP goal(mm Hg)?

Output: Recommended preferred anti-hypertensiveagent(s)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommended BP goal(mm Hg)?. ### Response: Recommended preferred anti-hypertensiveagent(s).


Instruction: Where can you find the Renal Association's CKD Guidelines396?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find the Renal Association's CKD Guidelines396?. ### Response: http://www.renal.org/Clinical/GuidelinesSection/.


Instruction: What is feasible to implement as it is currently being used in somesettings?

Output: The intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is feasible to implement as it is currently being used in somesettings?. ### Response: The intervention.


Instruction: Costs have not been formally assessed, but they are what?

Output: likely moderate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Costs have not been formally assessed, but they are what?. ### Response: likely moderate.


Instruction: What is the net health benefit/harm from using a visualmedication schedule to improve?

Output: adherence to anticoagulationtherapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the net health benefit/harm from using a visualmedication schedule to improve?. ### Response: adherence to anticoagulationtherapy.


Instruction: What is the cost of using a visual medication schedule for VTE patients?

Output: moderate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cost of using a visual medication schedule for VTE patients?. ### Response: moderate.


Instruction: What does the panel suggest against?

Output: periprocedural bridging with LMWH or UHF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the panel suggest against?. ### Response: periprocedural bridging with LMWH or UHF.


Instruction: What should be used for patients at low to moderate risk of recurrent VTE who require interruption of VKA therapy for invasive procedures?

Output: periprocedural bridging with LMWH or UHF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be used for patients at low to moderate risk of recurrent VTE who require interruption of VKA therapy for invasive procedures?. ### Response: periprocedural bridging with LMWH or UHF.


Instruction: What should LMWH or UHF be used?

Output: periprocedural bridging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should LMWH or UHF be used?. ### Response: periprocedural bridging.


Instruction: What is the ASH guideline panel's recommendation for patients at low to moderate risk of recurrent VTE?

Output: againstperiprocedural bridging with LMWH or UHF in favor of in-terruption of VKA alone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ASH guideline panel's recommendation for patients at low to moderate risk of recurrent VTE?. ### Response: againstperiprocedural bridging with LMWH or UHF in favor of in-terruption of VKA alone.


Instruction: What is a strong recommendation based on moderate certainty in the evidence about effects?

Output: in-terruption of VKA alone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a strong recommendation based on moderate certainty in the evidence about effects?. ### Response: in-terruption of VKA alone.


Instruction: How many systematic reviews did we find that addressed this question?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many systematic reviews did we find that addressed this question?. ### Response: 1.


Instruction: Why did we not use any studies in evidence?

Output: they evaluated patientsreceiving anticoagulation therapy for mixed indications, and iso-lating the minority of patients with low to moderate risk of recurrentVTE was not possible

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why did we not use any studies in evidence?. ### Response: they evaluated patientsreceiving anticoagulation therapy for mixed indications, and iso-lating the minority of patients with low to moderate risk of recurrentVTE was not possible.


Instruction: Iso-lating the minority of patients with low to moderate risk of recurrentVTE was not possible?

Output: (1) they evaluated patientsreceiving anticoagulation therapy for mixed indications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Iso-lating the minority of patients with low to moderate risk of recurrentVTE was not possible?. ### Response: (1) they evaluated patientsreceiving anticoagulation therapy for mixed indications.


Instruction: What did the studies include only patients withindications for other than VTE?

Output: anticoagulation therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the studies include only patients withindications for other than VTE?. ### Response: anticoagulation therapy.


Instruction: What was a surrogate measure of quality-of-life impairment?

Output: patient satisfaction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a surrogate measure of quality-of-life impairment?. ### Response: patient satisfaction.


Instruction: What was an RCT evaluating?

Output: uninterrupted vs interrupted anticoagulation during pacemaker ordefibrillator surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was an RCT evaluating?. ### Response: uninterrupted vs interrupted anticoagulation during pacemaker ordefibrillator surgery.


Instruction: What is a surrogate measure of quality-of-life impairment?

Output: patient satisfaction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a surrogate measure of quality-of-life impairment?. ### Response: patient satisfaction.


Instruction: What percentage of patients in this study had VTE as an indication for anticoagulation therapy?

Output: 5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients in this study had VTE as an indication for anticoagulation therapy?. ### Response: 5%.


Instruction: The EtD framework is shown online at https://dbep.gradepro.org/profile/510d8142-f0d4-4 7f4-8998-e153cec6018f What are the benefits of EtD?

Output: Benefits. For benefits, see the evidence profile in the EtDframework referenced at the end of the previous section, availableonline. There was no effect of bridging therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The EtD framework is shown online at https://dbep.gradepro.org/profile/510d8142-f0d4-4 7f4-8998-e153cec6018f What are the benefits of EtD?. ### Response: Benefits. For benefits, see the evidence profile in the EtDframework referenced at the end of the previous section, availableonline. There was no effect of bridging therapy.


Instruction: What is shown online at https://dbep.gradepro.org/profile/510d8142-f0d4-4 7f4-8998-e153cec6018f?

Output: EtD framework

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is shown online at https://dbep.gradepro.org/profile/510d8142-f0d4-4 7f4-8998-e153cec6018f?. ### Response: EtD framework.


Instruction: What was no effect of bridging therapy on mortality risk?

Output: no deaths occurred during the 30-day follow-up period

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was no effect of bridging therapy on mortality risk?. ### Response: no deaths occurred during the 30-day follow-up period.


Instruction: What can cause urticarial skin reac-tions?

Output: Heparin and LMWH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can cause urticarial skin reac-tions?. ### Response: Heparin and LMWH.


Instruction: What should be suspected in cases of skin necrosis at sites of injec-tion?

Output: HIT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be suspected in cases of skin necrosis at sites of injec-tion?. ### Response: HIT.


Instruction: How many different LMWH preparations did a patient develop skin reactions to?

Output: three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many different LMWH preparations did a patient develop skin reactions to?. ### Response: three.


Instruction: How many different LMWH preparations did people develop skin reactions to?

Output: three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many different LMWH preparations did people develop skin reactions to?. ### Response: three.


Instruction: What has been limited to to date studies on the effects of fondaparinux on bone metabolism?

Output: in vitro exper-iments using cultured osteoblasts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been limited to to date studies on the effects of fondaparinux on bone metabolism?. ### Response: in vitro exper-iments using cultured osteoblasts.


Instruction: In one study, fondaparainux was compared with heparin, dalteparin or what?

Output: enoxaparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In one study, fondaparainux was compared with heparin, dalteparin or what?. ### Response: enoxaparin.


Instruction: What did fondaparinux show higher mitochondrial activity and protein synthesis than?

Output: unexposed osteoblasts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did fondaparinux show higher mitochondrial activity and protein synthesis than?. ### Response: unexposed osteoblasts.


Instruction: What did therapeutically relevant concentrations of heparin, dalteparin or enoxaparain decrease?

Output: matrix collagen type 2 content and calcification

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did therapeutically relevant concentrations of heparin, dalteparin or enoxaparain decrease?. ### Response: matrix collagen type 2 content and calcification.


Instruction: What did fonda-parinux have no effect on?

Output: osteo-blastic activity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did fonda-parinux have no effect on?. ### Response: osteo-blastic activity.


Instruction: What did a second study compare the effects of fondaparinx and dalteparin on human osteoblasts in culture?

Output: inhibited osteoblast prolifera-tion, protein synthesis, and the decreased levels of osteocalcin and alkaline phosphatase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a second study compare the effects of fondaparinx and dalteparin on human osteoblasts in culture?. ### Response: inhibited osteoblast prolifera-tion, protein synthesis, and the decreased levels of osteocalcin and alkaline phosphatase.


Instruction: Dalteparain inhibited osteoblast prolifera-tion, protein synthesis, and the decreased levels of what?

Output: osteocalcin and alkaline phosphatase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Dalteparain inhibited osteoblast prolifera-tion, protein synthesis, and the decreased levels of what?. ### Response: osteocalcin and alkaline phosphatase.


Instruction: What did fondaparinux have no effect on?

Output: osteo-blastic activity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did fondaparinux have no effect on?. ### Response: osteo-blastic activity.


Instruction: What is not widely used in pregnancy because of insuffi cient safety data?

Output: fondaparinux

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not widely used in pregnancy because of insuffi cient safety data?. ### Response: fondaparinux.


Instruction: How many low levels of anti-Xa activity were detected in the umbilical cord blood in newborns of mothers treated with fondaparinux?

Output: 212

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many low levels of anti-Xa activity were detected in the umbilical cord blood in newborns of mothers treated with fondaparinux?. ### Response: 212.


Instruction: What is danaparoid Sodium a mixture of?

Output: glycosaminoglycans

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is danaparoid Sodium a mixture of?. ### Response: glycosaminoglycans.


Instruction: What does danaparoid act as?

Output: anticoagulant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does danaparoid act as?. ### Response: anticoagulant.


Instruction: What is the role of heparan sulfate in anticoagulation?

Output: decreased matrix collagen type 2 content and calcification

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of heparan sulfate in anticoagulation?. ### Response: decreased matrix collagen type 2 content and calcification.


Instruction: How long does half-life of danapraroid last?

Output: 25 h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does half-life of danapraroid last?. ### Response: 25 h.


Instruction: What is the half-life of danaparoid?

Output: 25

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the half-life of danaparoid?. ### Response: 25.


Instruction: What was shown to be effective for the prevention of venous thrombosis in high-risk patients?

Output: fondaparinux

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was shown to be effective for the prevention of venous thrombosis in high-risk patients?. ### Response: fondaparinux.


Instruction: What is the only agent that has been evaluated for HIT in a randomized clinical trial?

Output: Danaparoid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the only agent that has been evaluated for HIT in a randomized clinical trial?. ### Response: Danaparoid.


Instruction: What was reported to be signifi cantly better than dextran?

Output: Danaparoid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was reported to be signifi cantly better than dextran?. ### Response: Danaparoid.


Instruction: High success rates in the treatment of HIT have also been observed in what studies?

Output: retrospective studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: High success rates in the treatment of HIT have also been observed in what studies?. ### Response: retrospective studies.


Instruction: Danaparoid is approved for what in some countries?

Output: the treatment of HIT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Danaparoid is approved for what in some countries?. ### Response: the treatment of HIT.


Instruction: What country does Danaparoid not prolong the INR?

Output: United States

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What country does Danaparoid not prolong the INR?. ### Response: United States.


Instruction: What is the compound most bound to?

Output: AT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the compound most bound to?. ### Response: AT.


Instruction: How long does the compound last after it is almost complete bioavailability?

Output: 25 h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does the compound last after it is almost complete bioavailability?. ### Response: 25 h.


Instruction: What is not recommended for patients whose CT brain imaging exhibits extensive regions of clear hypoattenuation?

Output: administering IV alteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended for patients whose CT brain imaging exhibits extensive regions of clear hypoattenuation?. ### Response: administering IV alteplase.


Instruction: What is a poor prognosis despite IV alteplase?

Output: patients whose CT brain imaging exhibits extensive regions of clear hypoattenuation is not recommended. These patients have a poor prognosis despite IV alteplase, and severe hypoattenuation defined as obvious hypodensity represents irreversible injury

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a poor prognosis despite IV alteplase?. ### Response: patients whose CT brain imaging exhibits extensive regions of clear hypoattenuation is not recommended. These patients have a poor prognosis despite IV alteplase, and severe hypoattenuation defined as obvious hypodensity represents irreversible injury.


Instruction: What is severe hypoattenuation defined as?

Output: obvious hypodensity represents irreversible injury

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is severe hypoattenuation defined as?. ### Response: obvious hypodensity represents irreversible injury.


Instruction: What is irreversible injury?

Output: severe hypoattenuation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is irreversible injury?. ### Response: severe hypoattenuation.


Instruction: Who should not be given IV alteplase to a patient whose CT shows an acute intracranial hemorrhage?

Output: ICH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should not be given IV alteplase to a patient whose CT shows an acute intracranial hemorrhage?. ### Response: ICH.


Instruction: What is the term for intracranial hemorrhage?

Output: acute

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for intracranial hemorrhage?. ### Response: acute.


Instruction: Ischemic stroke within 3 mo Use of IV alteplase in patients with AIS may be what?

Output: harmful

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Ischemic stroke within 3 mo Use of IV alteplase in patients with AIS may be what?. ### Response: harmful.


Instruction: What is contraindicated in AIS patients with severe head trauma within 3 mo?

Output: IV alteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is contraindicated in AIS patients with severe head trauma within 3 mo?. ### Response: IV alteplase.


Instruction: What is the COR III: Harm; LOE C-EO?

Output: Coagulopathy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the COR III: Harm; LOE C-EO?. ### Response: Coagulopathy.


Instruction: IV alteplase should not be administered to what type of patient?

Output: acute stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: IV alteplase should not be administered to what type of patient?. ### Response: acute stroke.


Instruction: What should not be administered in posttraumatic infarction that occurs during the acute in-hospital phase?

Output: IV alteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not be administered in posttraumatic infarction that occurs during the acute in-hospital phase?. ### Response: IV alteplase.


Instruction: Intracranial/intraspinal surgery within 3 mo For patients with AIS and a history of what?

Output: intracranial/spinal surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Intracranial/intraspinal surgery within 3 mo For patients with AIS and a history of what?. ### Response: intracranial/spinal surgery.


Instruction: What is IV alteplase potentially harmful for?

Output: acute stroke patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is IV alteplase potentially harmful for?. ### Response: acute stroke patients.


Instruction: What is potentially harmful?

Output: Ischemic stroke within 3 mo Use of IV alteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is potentially harmful?. ### Response: Ischemic stroke within 3 mo Use of IV alteplase.


Instruction: Subarachnoid hemorrhage IV alteplase is contraindicated in patients presenting with symptoms and signs most consistent with what?

Output: an SAH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Subarachnoid hemorrhage IV alteplase is contraindicated in patients presenting with symptoms and signs most consistent with what?. ### Response: an SAH.


Instruction: What should patients with a structural GI malignancy or recent bleeding event within 21 d of their stroke event be considered?

Output: high risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients with a structural GI malignancy or recent bleeding event within 21 d of their stroke event be considered?. ### Response: high risk.


Instruction: What is IV alteplase administration potentially harmful?

Output: Ischemic stroke within 3 mo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is IV alteplase administration potentially harmful?. ### Response: Ischemic stroke within 3 mo.


Instruction: What is the efficacy of IV alteplase for acute stroke patients with platelets 100 000/mm3, INR >1.7, aPTT >40 s, or PT >15 s?

Output: unknown

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the efficacy of IV alteplase for acute stroke patients with platelets 100 000/mm3, INR >1.7, aPTT >40 s, or PT >15 s?. ### Response: unknown.


Instruction: What should not be administered?

Output: IV alteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not be administered?. ### Response: IV alteplase.


Instruction: What type of thrombocytopenia can be treated with IV alteplase?

Output: without history

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of thrombocytopenia can be treated with IV alteplase?. ### Response: without history.


Instruction: What should be discontinued if platelet count is 100 000/mm3?

Output: IV alteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be discontinued if platelet count is 100 000/mm3?. ### Response: IV alteplase.


Instruction: In patients without recent use of OACs or heparin, what can be initiated before availability of coagulation test results?

Output: treatment with IV alteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients without recent use of OACs or heparin, what can be initiated before availability of coagulation test results?. ### Response: treatment with IV alteplase.


Instruction: What should be discontinued if INR is >1.7 or PT is abnormally elevated by local laboratory standards?

Output: treatment with IV alteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be discontinued if INR is >1.7 or PT is abnormally elevated by local laboratory standards?. ### Response: treatment with IV alteplase.


Instruction: What is the name of the trial in patients with acute HF that demonstrated a high-dose furosemide strategy?

Output: Diuretic Optimization Strategies Evaluation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the trial in patients with acute HF that demonstrated a high-dose furosemide strategy?. ### Response: Diuretic Optimization Strategies Evaluation.


Instruction: What strategy was asso-ciated with a nonstatistically significant trend toward greater improvement in patients’ global assessment of symptoms?

Output: high-dose furosemide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What strategy was asso-ciated with a nonstatistically significant trend toward greater improvement in patients’ global assessment of symptoms?. ### Response: high-dose furosemide.


Instruction: What did the high-dose furosemide strategy show no significant difference in?

Output: creatinine levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the high-dose furosemide strategy show no significant difference in?. ### Response: creatinine levels.


Instruction: What is thought to reduce the remodeling that occurs after MI?

Output: ACE InhibitorsACE inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is thought to reduce the remodeling that occurs after MI?. ### Response: ACE InhibitorsACE inhibitors.


Instruction: What are ACE inhibitors thought to improve?

Output: ischemic preconditioning

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are ACE inhibitors thought to improve?. ### Response: ischemic preconditioning.


Instruction: To reverse angiotensin II-induced vasoconstriction and inotropy?

Output: ACE InhibitorsACE inhibitors are thought to reduce the remodeling that occurs after MI,249 to improve ischemic preconditioning,250

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: To reverse angiotensin II-induced vasoconstriction and inotropy?. ### Response: ACE InhibitorsACE inhibitors are thought to reduce the remodeling that occurs after MI,249 to improve ischemic preconditioning,250.


Instruction: Inotropy is used to prevent the depletion of what?

Output: high-energy phosphate stores

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Inotropy is used to prevent the depletion of what?. ### Response: high-energy phosphate stores.


Instruction: To enhance nitric oxide release through prevention of what breakdown?

Output: bradyki-nin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: To enhance nitric oxide release through prevention of what breakdown?. ### Response: bradyki-nin.


Instruction: ACE inhibitors have been shown in many trials to be ben-eficial in patients with what type of dysfunction?

Output: LV dysfunction of ischemic origin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ACE inhibitors have been shown in many trials to be ben-eficial in patients with what type of dysfunction?. ### Response: LV dysfunction of ischemic origin.


Instruction: What did the TRandolapril Cardiac Evaluation (TRACE) trial show a 7% reduction in?

Output: mortality rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the TRandolapril Cardiac Evaluation (TRACE) trial show a 7% reduction in?. ### Response: mortality rate.


Instruction: What was the relative mortality risk of ramipril administered 3 to 7 days after MI reduced by 27% in the AIRE trial?

Output: total cohort

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the relative mortality risk of ramipril administered 3 to 7 days after MI reduced by 27% in the AIRE trial?. ### Response: total cohort.


Instruction: How much did MI reduce the relative mortality risk after MI?

Output: 27%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much did MI reduce the relative mortality risk after MI?. ### Response: 27%.


Instruction: How much was reduced by MI in normotensive subjects?

Output: 15%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much was reduced by MI in normotensive subjects?. ### Response: 15%.


Instruction: What is the importance of inhibition of ACE in LV dysfunction in the post-MI period?

Output: reduce the remodeling

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the importance of inhibition of ACE in LV dysfunction in the post-MI period?. ### Response: reduce the remodeling.


Instruction: What was significantly lower in patients with HF who received a high dose of lisinopril than in those treated with a low dose?

Output: mor -tality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was significantly lower in patients with HF who received a high dose of lisinopril than in those treated with a low dose?. ### Response: mor -tality.


Instruction: What is the name of the ATLAS trial?

Output: Assessment of Treatment With Lisinopril and Survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the ATLAS trial?. ### Response: Assessment of Treatment With Lisinopril and Survival.


Instruction: What is the dose of lisinopril?

Output: 32.5–35 mg/d

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the dose of lisinopril?. ### Response: 32.5–35 mg/d.


Instruction: What are ACE inhibitors most notable for in patients with diabetes mellitus or other cardiovascular complica-tions?

Output: 16,18

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are ACE inhibitors most notable for in patients with diabetes mellitus or other cardiovascular complica-tions?. ### Response: 16,18.


Instruction: In the IMPROVE-HF registry, what percentage of clinicians have not been impacted as well as it should?

Output: ACE inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the IMPROVE-HF registry, what percentage of clinicians have not been impacted as well as it should?. ### Response: ACE inhibitors.


Instruction: How many patients with LV dysfunction were prescribed an ACE inhibitor/ARB at baseline?

Output: ≈80%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with LV dysfunction were prescribed an ACE inhibitor/ARB at baseline?. ### Response: ≈80%.


Instruction: What did the ARBs losartan255 and irbesar -tan256 significantly reduce the incidence of?

Output: HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the ARBs losartan255 and irbesar -tan256 significantly reduce the incidence of?. ### Response: HF.


Instruction: What was found to be noninferior to captopril in the V ALIANT trial?

Output: valsartan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was found to be noninferior to captopril in the V ALIANT trial?. ### Response: valsartan.


Instruction: What did the evaluation of Losartan show in patients with type 2 diabetes mellitus?

Output: reduced the incidence of HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the evaluation of Losartan show in patients with type 2 diabetes mellitus?. ### Response: reduced the incidence of HF.


Instruction: How many patients had reconstructed time-to-event data?

Output: 3,560

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had reconstructed time-to-event data?. ### Response: 3,560.


Instruction: How many randomised clinical trials were included in the meta-analysis?

Output: six

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many randomised clinical trials were included in the meta-analysis?. ### Response: six.


Instruction: What is the name of the study that evaluated transcatheter closure of patent foramen ovale?

Output: antithrom-botic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated transcatheter closure of patent foramen ovale?. ### Response: antithrom-botic therapy.


Instruction: What does Closure of patent foramen ovale do for cryptogenic stroke patients?

Output: preventing recurrent stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Closure of patent foramen ovale do for cryptogenic stroke patients?. ### Response: preventing recurrent stroke.


Instruction: What is the name of the updated systematic review and meta-analysis of randomized trials?

Output: Closure of patent foramen ovale for cryptogenic stroke patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the updated systematic review and meta-analysis of randomized trials?. ### Response: Closure of patent foramen ovale for cryptogenic stroke patients.


Instruction: When did Closure versus medical therapy for preventing recurrent stroke occur?

Output: 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Closure versus medical therapy for preventing recurrent stroke occur?. ### Response: 2018.


Instruction: What is the difference between medical therapy and patent foramen ovale closure?

Output: preventing recurrent stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between medical therapy and patent foramen ovale closure?. ### Response: preventing recurrent stroke.


Instruction: What type of stroke are patent foramnes ovale patients at risk for?

Output: cryptogenic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of stroke are patent foramnes ovale patients at risk for?. ### Response: cryptogenic.


Instruction: How does Closure compare to medical therapy?

Output: ovale closure over medical therapy after cryptogenic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does Closure compare to medical therapy?. ### Response: ovale closure over medical therapy after cryptogenic stroke.


Instruction: What does patent foramen ovale closure over medical therapy after cryptogenic stroke support?

Output: quality of ev-idence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does patent foramen ovale closure over medical therapy after cryptogenic stroke support?. ### Response: quality of ev-idence.


Instruction: What is the doi: 10.1093/eurheartj/ehy496 325?

Output: ovale closure over medical therapy after cryptogenic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the doi: 10.1093/eurheartj/ehy496 325?. ### Response: ovale closure over medical therapy after cryptogenic stroke.


Instruction: In what year did Stroke. 2009:40:2727-2731?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did Stroke. 2009:40:2727-2731?. ### Response: 2009.


Instruction: What is the most common type of stenosis?

Output: ca-rotid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common type of stenosis?. ### Response: ca-rotid.


Instruction: What type of intervention is recommended for recently symptomatic stenoses?

Output: early carotid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of intervention is recommended for recently symptomatic stenoses?. ### Response: early carotid.


Instruction: When did Stroke. 2015 issue 46?

Output: 3423–34

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Stroke. 2015 issue 46?. ### Response: 3423–34.


Instruction: What is stenosis based on?

Output: meta-analysis of current risks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is stenosis based on?. ### Response: meta-analysis of current risks.


Instruction: What is the time window recommended for carotid endarterectomy?

Output: Stroke recur -rence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the time window recommended for carotid endarterectomy?. ### Response: Stroke recur -rence.


Instruction: What is a recommended time window for carotid endarterectomy?

Output: Stroke recur -rence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a recommended time window for carotid endarterectomy?. ### Response: Stroke recur -rence.


Instruction: What is the ANSYSCAP study?

Output: Risk of recurrent stroke before ca-rotid endarterectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ANSYSCAP study?. ### Response: Risk of recurrent stroke before ca-rotid endarterectomy.


Instruction: What is risk of early recurrent stroke in symptomatic carotid stenosis?

Output: High

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is risk of early recurrent stroke in symptomatic carotid stenosis?. ### Response: High.


Instruction: What is the doi: 10.1016/j.ejvs.2014.11.004330?

Output: 10.4244/EIJ-D-18-00341 322

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the doi: 10.1016/j.ejvs.2014.11.004330?. ### Response: 10.4244/EIJ-D-18-00341 322.


Instruction: What is the name of the surgical procedure for symptomatic stenosis?

Output: carotid endarterectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the surgical procedure for symptomatic stenosis?. ### Response: carotid endarterectomy.


Instruction: What is one of the outcomes of early carotid endarterectomy?

Output: Acute carotid ar -tery stenting in symptomatic high-grade cervical carotid artery stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the outcomes of early carotid endarterectomy?. ### Response: Acute carotid ar -tery stenting in symptomatic high-grade cervical carotid artery stenosis.


Instruction: How many patients died from cerebral infarct in 2016?

Output: 329

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients died from cerebral infarct in 2016?. ### Response: 329.


Instruction: What type of endarterectomy is recommended after intravenous thrombolysis?

Output: Acute carotid ar -tery stenting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of endarterectomy is recommended after intravenous thrombolysis?. ### Response: Acute carotid ar -tery stenting.


Instruction: What is the name of the 2016 issue of Eur J Vasc Endovasc Surg?

Output: 51:482–486

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2016 issue of Eur J Vasc Endovasc Surg?. ### Response: 51:482–486.


Instruction: When was the last issue of Neurosurg Rev. 2017 published?

Output: 40

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last issue of Neurosurg Rev. 2017 published?. ### Response: 40.


Instruction: What is angiograms with chelation?

Output: randomized controlled trial (RCT) examining the effect of chelation therapy on SIHD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is angiograms with chelation?. ### Response: randomized controlled trial (RCT) examining the effect of chelation therapy on SIHD.


Instruction: How many patients were studied in a randomized controlled trial?

Output: 84

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were studied in a randomized controlled trial?. ### Response: 84.


Instruction: What did the 84 patients with stable angina and a positive treadmill test for ischemia receive in the RCT?

Output: weight-adjusted disodium EDTA chelation therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the 84 patients with stable angina and a positive treadmill test for ischemia receive in the RCT?. ### Response: weight-adjusted disodium EDTA chelation therapy.


Instruction: For how many weeks did the patients with active therapy receive weight-adjusted EDTA?

Output: 15

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For how many weeks did the patients with active therapy receive weight-adjusted EDTA?. ### Response: 15.


Instruction: How many hours per treatment?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many hours per treatment?. ### Response: 3.


Instruction: How many times weekly for 15 weeks and once monthly for an additional 3 months?

Output: twice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many times weekly for 15 weeks and once monthly for an additional 3 months?. ### Response: twice.


Instruction: What was the difference between groups in changes in exercise time to ischemia, exercise capacity, or quality-of-life scores?

Output: no

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the difference between groups in changes in exercise time to ischemia, exercise capacity, or quality-of-life scores?. ### Response: no.


Instruction: Who are the National Center of Complementary and Alternative Medicine?

Output: National Heart, Lung, and Blood Institute

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who are the National Center of Complementary and Alternative Medicine?. ### Response: National Heart, Lung, and Blood Institute.


Instruction: What did the National Heart, Lung, and Blood Institute conduct?

Output: TACT (Trial to Assess Chelation Therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the National Heart, Lung, and Blood Institute conduct?. ### Response: TACT (Trial to Assess Chelation Therapy.


Instruction: What was the primary composite endpoint of the TACT?

Output: total mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary composite endpoint of the TACT?. ### Response: total mortality.


Instruction: How many patients were hospitalized for angina in the chelation group?

Output: 222

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were hospitalized for angina in the chelation group?. ### Response: 222.


Instruction: What was the risk ratio for MI, stroke, coronary revascularization, or hospitalization?

Output: 0.82

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk ratio for MI, stroke, coronary revascularization, or hospitalization?. ### Response: 0.82.


Instruction: Why was statistical significance considered at P values  0.036?

Output: because of multiple comparisons

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was statistical significance considered at P values  0.036?. ### Response: because of multiple comparisons.


Instruction: What was considered significance at P values  0.036?

Output: statistical significance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was considered significance at P values  0.036?. ### Response: statistical significance.


Instruction: No individual endpoint differed significantly between groups?

Output: changes in exercise time to ischemia, exercise capacity, or quality-of-life scores

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No individual endpoint differed significantly between groups?. ### Response: changes in exercise time to ischemia, exercise capacity, or quality-of-life scores.


Instruction: What was the hazard ratio among patients with diabetes mellitus?

Output: 0.61

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the hazard ratio among patients with diabetes mellitus?. ### Response: 0.61.


Instruction: How much reduction was there in the composite endpoint for the chelation-treated patients relative to the placebo-treated?

Output: 39%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much reduction was there in the composite endpoint for the chelation-treated patients relative to the placebo-treated?. ### Response: 39%.


Instruction: What did the TACT investigators not recommend for all patients with SIHD?

Output: the routine use of chelation therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the TACT investigators not recommend for all patients with SIHD?. ### Response: the routine use of chelation therapy.


Instruction: What percentage of patients lost to withdrawal from chelation therapy?

Output: 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients lost to withdrawal from chelation therapy?. ### Response: 50%.


Instruction: How many patients withdrew from chelation therapy than from placebo?

Output: 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients withdrew from chelation therapy than from placebo?. ### Response: 50%.


Instruction: What percentage of patients lost to follow-up after treatment?

Output: 18%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients lost to follow-up after treatment?. ### Response: 18%.


Instruction: What is chelation therapy not risk free?

Output: Disodium EDTA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is chelation therapy not risk free?. ### Response: Disodium EDTA.


Instruction: What can disodium EDTA cause when infused too rapidly?

Output: hypocalcemia, renal failure, and death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can disodium EDTA cause when infused too rapidly?. ### Response: hypocalcemia, renal failure, and death.


Instruction: What can happen if EDTA is used too quickly?

Output: hypocalcemia, renal failure, and death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can happen if EDTA is used too quickly?. ### Response: hypocalcemia, renal failure, and death.


Instruction: What is the FDA's approval of disodiumEDTA?

Output: specific indications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the FDA's approval of disodiumEDTA?. ### Response: specific indications.


Instruction: For what are two examples of indications for edta?

Output: iron overload and lead poisoning

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For what are two examples of indications for edta?. ### Response: iron overload and lead poisoning.


Instruction: What does the writing group consider the usefulness of in cardiac disease?

Output: chelation therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the writing group consider the usefulness of in cardiac disease?. ### Response: chelation therapy.


Instruction: What is the recommendation on enhanced external counterpulsation?

Output: See Table 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommendation on enhanced external counterpulsation?. ### Response: See Table 3.


Instruction: What is EECP?

Output: enhanced external counterpulsation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is EECP?. ### Response: enhanced external counterpulsation.


Instruction: What is Online Data Supplement 3 for?

Output: evidence supporting the recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Online Data Supplement 3 for?. ### Response: evidence supporting the recommendation.


Instruction: What is the name of the randomized trial of beta -blockade in heart failure?

Output: The Cardiac Insufficiency Bisoprolol Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized trial of beta -blockade in heart failure?. ### Response: The Cardiac Insufficiency Bisoprolol Study.


Instruction: What is CIBIS?

Output: Cardiac Insufficiency Bisoprolol Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CIBIS?. ### Response: Cardiac Insufficiency Bisoprolol Study.


Instruction: What is the acronym for the Cardiac Insufficiency Bisoprolol Study?

Output: CIBIS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the Cardiac Insufficiency Bisoprolol Study?. ### Response: CIBIS.


Instruction: What does CIBIS stand for?

Output: Cardiac Insufficiency Bisoprolol Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CIBIS stand for?. ### Response: Cardiac Insufficiency Bisoprolol Study.


Instruction: When was the randomized clinical trial conducted?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the randomized clinical trial conducted?. ### Response: 2013.


Instruction: What is the name of the randomized clinical trial of heart failure?

Output: The Auckland Heart Failure Management Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized clinical trial of heart failure?. ### Response: The Auckland Heart Failure Management Study.


Instruction: What are the natriuretic peptide levels associated with in an ambulatory cohort?

Output: echocardiographically determined left ventricular diastolic function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the natriuretic peptide levels associated with in an ambulatory cohort?. ### Response: echocardiographically determined left ventricular diastolic function.


Instruction: What is left ventricular diastolic function in an ambulatory cohort?

Output: N -terminal pro B -type natriuretic peptide levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is left ventricular diastolic function in an ambulatory cohort?. ### Response: N -terminal pro B -type natriuretic peptide levels.


Instruction: What is the Journal of the American Society of Echocardiography?

Output: Health Expectations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Journal of the American Society of Echocardiography?. ### Response: Health Expectations.


Instruction: Disease multimorbidity at hospital discharge transition: a study of patient and carer experience.

Output: Heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Disease multimorbidity at hospital discharge transition: a study of patient and carer experience.. ### Response: Heart failure.


Instruction: What is the name of the randomized, controlled trial of integrated heart failure management?

Output: The Auckland Heart Failure Management Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized, controlled trial of integrated heart failure management?. ### Response: The Auckland Heart Failure Management Study.


Instruction: What is the name of the study that focuses on heart failure management?

Output: The Auckland Heart Failure Management Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that focuses on heart failure management?. ### Response: The Auckland Heart Failure Management Study.


Instruction: When was the European Heart Journal published?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the European Heart Journal published?. ### Response: 2002.


Instruction: What did Driscoll say about the impact of Dietary Sodium Restriction?

Output: Driscoll A

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Driscoll say about the impact of Dietary Sodium Restriction?. ### Response: Driscoll A.


Instruction: What is the name of the randomized controlled trial that improves chronic heart failure optimization of beta -adrenergic receptor blocking therapy?

Output: A nurse -led up -titration clinic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized controlled trial that improves chronic heart failure optimization of beta -adrenergic receptor blocking therapy?. ### Response: A nurse -led up -titration clinic.


Instruction: When did BMC Research Notes publish its 7:668 106?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did BMC Research Notes publish its 7:668 106?. ### Response: 2014.


Instruction: What is the name of the journal that describes the impact of care at a multidisciplinary congestive heart failure clinic: a randomized trial?

Output: CMAJ: Canadian Medical Association Journal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that describes the impact of care at a multidisciplinary congestive heart failure clinic: a randomized trial?. ### Response: CMAJ: Canadian Medical Association Journal.


Instruction: When was the CMAJ published?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the CMAJ published?. ### Response: 2005.


Instruction: What is a budget impact model for for a drug in heart failure called?

Output: Eplerenone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a budget impact model for for a drug in heart failure called?. ### Response: Eplerenone.


Instruction: What is the name of the drug used to treat heart failure?

Output: beta -blockade

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used to treat heart failure?. ### Response: beta -blockade.


Instruction: When was the British Journal of Cardiology published?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the British Journal of Cardiology published?. ### Response: 2008.


Instruction: What is spironolactone used for in patients with symptomatic diastolic heart failure?

Output: exercise capacity and diastolic function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is spironolactone used for in patients with symptomatic diastolic heart failure?. ### Response: exercise capacity and diastolic function.


Instruction: What is Aldo -DHF?

Output: symptomatic diastolic heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Aldo -DHF?. ### Response: symptomatic diastolic heart failure.


Instruction: What is a symptomatic diastolic heart failure?

Output: Aldo -DHF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a symptomatic diastolic heart failure?. ### Response: Aldo -DHF.


Instruction: What is the European Journal of Heart Failure. 2010; 12(8):874 -82 109.

Output: a double -blind, randomized, place bo-controlled, parallel group study to determine the effects of spironolactone on exercise capacity and diastolic function in patients with symptomatic diastolic heart failure (Aldo -DHF). European Journal of Heart Failure. 2010; 12(8):874 -82 109.  Edelmann F, Wachter R, Schmidt AG, Kraigher -Krainer E, Colantonio C, Kamke W et al. Effect of spironolactone on diastolic function and exercise capacity in patients with heart failure with preserved ejection fraction: The Aldo -DHF randomized controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the European Journal of Heart Failure. 2010; 12(8):874 -82 109.. ### Response: a double -blind, randomized, place bo-controlled, parallel group study to determine the effects of spironolactone on exercise capacity and diastolic function in patients with symptomatic diastolic heart failure (Aldo -DHF). European Journal of Heart Failure. 2010; 12(8):874 -82 109.  Edelmann F, Wachter R, Schmidt AG, Kraigher -Krainer E, Colantonio C, Kamke W et al. Effect of spironolactone on diastolic function and exercise capacity in patients with heart failure with preserved ejection fraction: The Aldo -DHF randomized controlled trial.


Instruction: What does spironolactone do?

Output: exercise capacity and diastolic function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does spironolactone do?. ### Response: exercise capacity and diastolic function.


Instruction: What is the name of the randomized controlled trial in patients with heart failure?

Output: The Auckland Heart Failure Management Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized controlled trial in patients with heart failure?. ### Response: The Auckland Heart Failure Management Study.


Instruction: What was the ejection fraction preserved in the Aldo-DHF trial?

Output: 781 -791

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the ejection fraction preserved in the Aldo-DHF trial?. ### Response: 781 -791.


Instruction: What are some examples of decongestants?

Output: phenylephrine, pseudoephedrine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some examples of decongestants?. ### Response: phenylephrine, pseudoephedrine.


Instruction: What is one alternative therapy for hypertension?

Output: nasal saline, intranasal corticosteroids, antihistamines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one alternative therapy for hypertension?. ### Response: nasal saline, intranasal corticosteroids, antihistamines.


Instruction: How do you avoid using immunosuppressants?

Output: Consider converting to tacrolimus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do you avoid using immunosuppressants?. ### Response: Consider converting to tacrolimus.


Instruction: What is an example of a immunosuppressant?

Output: cyclosporine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a immunosuppressant?. ### Response: cyclosporine.


Instruction: What is a low-dose form of contraception?

Output: progestin-only

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a low-dose form of contraception?. ### Response: progestin-only.


Instruction: How many mcg is ethinyl estradiol?

Output: 20–30

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mcg is ethinyl estradiol?. ### Response: 20–30.


Instruction: What are some examples of analgesics that can be used to treat hypertension in women?

Output: acetaminophen, tramadol, topical NSAIDs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some examples of analgesics that can be used to treat hypertension in women?. ### Response: acetaminophen, tramadol, topical NSAIDs.


Instruction: What is a common example of a recreational drug?

Output: bath salts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a common example of a recreational drug?. ### Response: bath salts.


Instruction: What is an example of a systemic corticosteroids?

Output: dexamethasone, fludrocortisone, methylprednisolone, prednisone, prednisolone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a systemic corticosteroids?. ### Response: dexamethasone, fludrocortisone, methylprednisolone, prednisone, prednisolone.


Instruction: What is a tyrosine kinase inhibitor?

Output: sunitinib, sorafenib

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a tyrosine kinase inhibitor?. ### Response: sunitinib, sorafenib.


Instruction: How does ADHD indicate attention-deficit/hyperactivity disorder?

Output: BP, blood pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does ADHD indicate attention-deficit/hyperactivity disorder?. ### Response: BP, blood pressure.


Instruction: What is the acronym for attention deficit/hyperactivity disorder?

Output: ADHD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for attention deficit/hyperactivity disorder?. ### Response: ADHD.


Instruction: What does MAOI stand for?

Output: monoamine-oxidase inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does MAOI stand for?. ### Response: monoamine-oxidase inhibitors.


Instruction: Where can ahajournals.org be accessed by May 3, 2023?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can ahajournals.org be accessed by May 3, 2023?. ### Response: http://.


Instruction: What is the natriuretic peptide associated with in asymptomatic degenerative mitral regurgitation?

Output: survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the natriuretic peptide associated with in asymptomatic degenerative mitral regurgitation?. ### Response: survival.


Instruction: In what year did Heart issue 98:584-91?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did Heart issue 98:584-91?. ### Response: 2012.


Instruction: What is a prognostic value of global longitudinal strain after surgery for primary care?

Output: etiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a prognostic value of global longitudinal strain after surgery for primary care?. ### Response: etiology.


Instruction: What is etiology after surgery for primary mitral re-gurgitation?

Output: Prognostic value of global longitudinal strain

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is etiology after surgery for primary mitral re-gurgitation?. ### Response: Prognostic value of global longitudinal strain.


Instruction: What is the JACC Cardiovasc Imaging. 2020?

Output: 13:577–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the JACC Cardiovasc Imaging. 2020?. ### Response: 13:577–.


Instruction: Who is Clavel M-A, Tribouilloy C, Vanoverschelde J-L?

Output: 20. Clavel M-A, Tribouilloy C, Vanoverschelde J-L, et al. Association of B-type natriuretic peptide with survival in patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Clavel M-A, Tribouilloy C, Vanoverschelde J-L?. ### Response: 20. Clavel M-A, Tribouilloy C, Vanoverschelde J-L, et al. Association of B-type natriuretic peptide with survival in patients.


Instruction: How does B-type natriuretic peptide affect survival?

Output: Association of B-type natriuretic peptide with survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does B-type natriuretic peptide affect survival?. ### Response: Association of B-type natriuretic peptide with survival.


Instruction: What year did Am Coll Cardiol have a 68:1297–307.

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Am Coll Cardiol have a 68:1297–307.. ### Response: 2016.


Instruction: What is the name of the study that used myocardial strain in prediction of outcomes after surgery for severe mitral regurgitation?

Output: JACC Cardiovasc Imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that used myocardial strain in prediction of outcomes after surgery for severe mitral regurgitation?. ### Response: JACC Cardiovasc Imaging.


Instruction: What year was Circulation.125:2138–50 published?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was Circulation.125:2138–50 published?. ### Response: 2012.


Instruction: Who is the author of Diagnostic Testing: Cardiac Catheterization?

Output: Nishimura RA, Carabello BA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of Diagnostic Testing: Cardiac Catheterization?. ### Response: Nishimura RA, Carabello BA.


Instruction: What is the name of the cardiac catheterization laboratory of the 21st century?

Output: Cardiac Catheterization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the cardiac catheterization laboratory of the 21st century?. ### Response: Cardiac Catheterization.


Instruction: Circulation. 2012;125:2138–50.

Output: Hemodynamics in the cardiac catheterization laboratory of the 21st century

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation. 2012;125:2138–50.. ### Response: Hemodynamics in the cardiac catheterization laboratory of the 21st century.


Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020 Page 67 of 127?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020 Page 67 of 127?. ### Response: 2.


Instruction: How many abstracts were reviewed?

Output: 12,005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many abstracts were reviewed?. ### Response: 12,005.


Instruction: What was excluded at the abstract level?

Output: citations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was excluded at the abstract level?. ### Response: citations.


Instruction: What was excluded at this level?

Output: Citations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was excluded at this level?. ### Response: Citations.


Instruction: What did not address a KQ, did not report on an outcome of interest, or were outside cutoff publication dates?

Output: Citations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did not address a KQ, did not report on an outcome of interest, or were outside cutoff publication dates?. ### Response: Citations.


Instruction: How many full-length articles were reviewed in Box 5?

Output: 863

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many full-length articles were reviewed in Box 5?. ### Response: 863.


Instruction: How many full length articles were reviewed?

Output: 863

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many full length articles were reviewed?. ### Response: 863.


Instruction: How many citations were excluded at 1st pass full article level?

Output: 439

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many citations were excluded at 1st pass full article level?. ### Response: 439.


Instruction: What criteria did articles excluded at this level not meet?

Output: inclusion criteria for clinical study or SR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What criteria did articles excluded at this level not meet?. ### Response: inclusion criteria for clinical study or SR.


Instruction: How many articles were reviewed in Box 7?

Output: 424

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many articles were reviewed in Box 7?. ### Response: 424.


Instruction: How many citations were excluded at 2nd pass KQ level?

Output: 283

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many citations were excluded at 2nd pass KQ level?. ### Response: 283.


Instruction: How many citations excluded at 2nd pass KQ level?

Output: 283

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many citations excluded at 2nd pass KQ level?. ### Response: 283.


Instruction: How many superseded by more comprehensive review or included in an SR?

Output: 71

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many superseded by more comprehensive review or included in an SR?. ### Response: 71.


Instruction: How many studies were included in Box 9?

Output: 141

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were included in Box 9?. ### Response: 141.


Instruction: What was not published in English?

Output: clinical trial or SR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not published in English?. ### Response: clinical trial or SR.


Instruction: What is the impact of quality report cards onchoice of physicians, hospitals, and HMOs: a midcourse evaluation?

Output: Will quality report cards help consumers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact of quality report cards onchoice of physicians, hospitals, and HMOs: a midcourse evaluation?. ### Response: Will quality report cards help consumers.


Instruction: What does Mukamel DB, Weimer DL, Mushlin AI interpret as evidence for effectiveness of quality reports?

Output: market sharechanges

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Mukamel DB, Weimer DL, Mushlin AI interpret as evidence for effectiveness of quality reports?. ### Response: market sharechanges.


Instruction: Report cards. MedCare. 2007;45:1227–32.763. Curry HH, Mordavsky JK. Consumer reports in health care: do they make a difference?

Output: Will quality report cards help consumers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Report cards. MedCare. 2007;45:1227–32.763. Curry HH, Mordavsky JK. Consumer reports in health care: do they make a difference?. ### Response: Will quality report cards help consumers.


Instruction: Shahian DM, Yip W, Westcott G, et al. Selection of a cardiac surgeryprovider in the managed care era.

Output: –89.764

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Shahian DM, Yip W, Westcott G, et al. Selection of a cardiac surgeryprovider in the managed care era.. ### Response: –89.764.


Instruction: What are the unintended consequences of publicly reporting quality information?

Output: use and abuse of practice profiles

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the unintended consequences of publicly reporting quality information?. ### Response: use and abuse of practice profiles.


Instruction: What do well-publicized risk-adjusted outcomesreports affect?

Output: hospital volume

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do well-publicized risk-adjusted outcomesreports affect?. ### Response: hospital volume.


Instruction: When did Med Care issue a 42:367–77.767?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Med Care issue a 42:367–77.767?. ### Response: 2004.


Instruction: Infor-mation: assessing salience, comprehension, and approaches for com-municating quality.

Output: Condition-specific performance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Infor-mation: assessing salience, comprehension, and approaches for com-municating quality.. ### Response: Condition-specific performance.


Instruction: Health Care Financ Rev. 1996;18:95–109.768.

Output: Jewett JJ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Health Care Financ Rev. 1996;18:95–109.768.. ### Response: Jewett JJ.


Instruction: What does Health Aff say will quality report cards help consumers?

Output: 1997;16:218–28.769

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Health Aff say will quality report cards help consumers?. ### Response: 1997;16:218–28.769.


Instruction: What did Milbank Q call decision-making research?

Output: Informing consumer decisions inhealth care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Milbank Q call decision-making research?. ### Response: Informing consumer decisions inhealth care.


Instruction: What did Hibbard JH, Peters E, Slovic P, et al. Make easier to use?

Output: health care quality report

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Hibbard JH, Peters E, Slovic P, et al. Make easier to use?. ### Response: health care quality report.


Instruction: When did Jt Comm J Qual Improv publish?

Output: 2001

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Jt Comm J Qual Improv publish?. ### Response: 2001.


Instruction: What is the name of the study that evaluated New York State’s approach to reporting cardiac surgeons?

Output: Report cards

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated New York State’s approach to reporting cardiac surgeons?. ### Response: Report cards.


Instruction: What was the title of the paper that assessed NewYork State's approach?

Output: Report cards on cardiac surgeons

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the title of the paper that assessed NewYork State's approach?. ### Response: Report cards on cardiac surgeons.


Instruction: What are the effects of “report cards” on health care providers?

Output: Will quality report cards help consumers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the effects of “report cards” on health care providers?. ### Response: Will quality report cards help consumers.


Instruction: What is the name of the journal that investigated the optimal surgical mortality?

Output: Circulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that investigated the optimal surgical mortality?. ### Response: Circulation.


Instruction: Who is the author of Outmigration for coronarybypass surgery in an era of public dissemination?

Output: Omoigui

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of Outmigration for coronarybypass surgery in an era of public dissemination?. ### Response: Omoigui.


Instruction: What is the effect of cardiac-surgery performancereports on referral practices and access to care?

Output: Schneider EC, Epstein AM. influence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of cardiac-surgery performancereports on referral practices and access to care?. ### Response: Schneider EC, Epstein AM. influence.


Instruction: What did a survey of cardiovascular specialists do?

Output: surgery performancereports on referral practices and access to care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a survey of cardiovascular specialists do?. ### Response: surgery performancereports on referral practices and access to care.


Instruction: Who published Risk Adjustment for Measuring Health Care Outcomes?

Output: Health Administration Press

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published Risk Adjustment for Measuring Health Care Outcomes?. ### Response: Health Administration Press.


Instruction: What is the name of the journal that dealt with the use and abuse of practice profiles?

Output: N Engl J Med.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that dealt with the use and abuse of practice profiles?. ### Response: N Engl J Med..


Instruction: When was the N Engl J Med 330:634–6.779 published?

Output: 1994

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the N Engl J Med 330:634–6.779 published?. ### Response: 1994.


Instruction: Who wrote the American Heart Association Scientific Statement from the Quality of Care and Outcomes Research Interdisciplinary Writing Group?

Output: Krumholz HM, Brindis RG, Brush JE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote the American Heart Association Scientific Statement from the Quality of Care and Outcomes Research Interdisciplinary Writing Group?. ### Response: Krumholz HM, Brindis RG, Brush JE.


Instruction: What does Quality of Care and Outcomes Research Interdisciplinary Writing Group do?

Output: Standards for statisticalmodels used for public reporting of health outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Quality of Care and Outcomes Research Interdisciplinary Writing Group do?. ### Response: Standards for statisticalmodels used for public reporting of health outcomes.


Instruction: What is Selker HP's job title?

Output: Systems for comparing actual and predicted mortality rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Selker HP's job title?. ### Response: Systems for comparing actual and predicted mortality rates.


Instruction: What is blood pressure-lowering treatment based on?

Output: cardiovascular risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is blood pressure-lowering treatment based on?. ### Response: cardiovascular risk.


Instruction: What is a meta-analysis of individual patient data?

Output: Bloodpressure-lowering treatment based on cardiovascular risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a meta-analysis of individual patient data?. ### Response: Bloodpressure-lowering treatment based on cardiovascular risk.


Instruction: What is the effect of pressure-lowering regimens on majorcardiovascular events?

Output: The effects of blood pressurereduction and of different blood pressure-lowering regimens on majorcardiovascular events according to baseline blood pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of pressure-lowering regimens on majorcardiovascular events?. ### Response: The effects of blood pressurereduction and of different blood pressure-lowering regimens on majorcardiovascular events according to baseline blood pressure.


Instruction: What was the name of the meta-analysis of randomized trials?

Output: Blood Pressure Lowering Treatment Trialists Collaboration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the meta-analysis of randomized trials?. ### Response: Blood Pressure Lowering Treatment Trialists Collaboration.


Instruction: What is the effect of intensive blood pressure lowering oncardiovascular and renal outcomes?

Output: risk ofmortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of intensive blood pressure lowering oncardiovascular and renal outcomes?. ### Response: risk ofmortality.


Instruction: What was the name of the updated systematic review andmeta-analysis?

Output: Lancet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the updated systematic review andmeta-analysis?. ### Response: Lancet.


Instruction: What is a randomized clinical trial of standardblood pressure control and cardiovascular disease outcomes in adults aged 75 years?

Output: JAMA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a randomized clinical trial of standardblood pressure control and cardiovascular disease outcomes in adults aged 75 years?. ### Response: JAMA.


Instruction: What is the name of the investigators for the SPRINT Research Group?

Output: SPRINT MIND

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the investigators for the SPRINT Research Group?. ### Response: SPRINT MIND.


Instruction: Effect of intensive vs standard blood pressure control on probable dementia?

Output: SPRINT MIND Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Effect of intensive vs standard blood pressure control on probable dementia?. ### Response: SPRINT MIND Investigators.


Instruction: What is the name of the randomized clinical trial that investigated probable dementia?

Output: SPRINT MIND

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized clinical trial that investigated probable dementia?. ### Response: SPRINT MIND.


Instruction: What is Brunstrom M, Carlberg B's affiliation with?

Output: mortality and cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Brunstrom M, Carlberg B's affiliation with?. ### Response: mortality and cardiovascular disease.


Instruction: What is the name of the meta-analysis of randomised controlled trials in people with and without chronic kidney disease?

Output: Blood Pressure Lowering Treatment Trialists Collaboration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis of randomised controlled trials in people with and without chronic kidney disease?. ### Response: Blood Pressure Lowering Treatment Trialists Collaboration.


Instruction: What does more intensive vs less intensive blood pressure lowering have to do with risk ofmortality?

Output: Association between moreintensive vs less intensive blood pressure lowering and risk ofmortality in chronic kidney disease stages 3 to 5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does more intensive vs less intensive blood pressure lowering have to do with risk ofmortality?. ### Response: Association between moreintensive vs less intensive blood pressure lowering and risk ofmortality in chronic kidney disease stages 3 to 5.


Instruction: What is the difference between intensive blood pressure lowering and risk ofmortality in chronic kidney disease stages 3 to 5?

Output: moreintensive vs less

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between intensive blood pressure lowering and risk ofmortality in chronic kidney disease stages 3 to 5?. ### Response: moreintensive vs less.


Instruction: When did JAMA Intern Med publish 177:1498-1505.112.

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did JAMA Intern Med publish 177:1498-1505.112.. ### Response: 2017.


Instruction: What did Garrison SR, Kolber MR, Korownyk CS do?

Output: Blood pressure targets forhypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Garrison SR, Kolber MR, Korownyk CS do?. ### Response: Blood pressure targets forhypertension.


Instruction: What does Cochrane Database Syst Rev do?

Output: meta-analysis of randomised controlled trials. BMJ. 2013;347:f5680 .111. Malhotra R, Nguyen HA, Benavente O, et al. Association between moreintensive vs less intensive blood pressure lowering and risk ofmortality in chronic kidney disease stages 3 to 5: a systematic reviewand meta-analysis. JAMA Intern Med . 2017;177:1498 –1505 .112.Garrison SR, Kolber MR, Korownyk CS, et al. Blood pressure targets forhypertension in older adults. Cochrane Database Syst Rev . 2017;8:CD011575 .113. Bavishi C, Bangalore S, Messerli FH. Outcomes of intensive bloodpressure lowering in older hypertensive patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Cochrane Database Syst Rev do?. ### Response: meta-analysis of randomised controlled trials. BMJ. 2013;347:f5680 .111. Malhotra R, Nguyen HA, Benavente O, et al. Association between moreintensive vs less intensive blood pressure lowering and risk ofmortality in chronic kidney disease stages 3 to 5: a systematic reviewand meta-analysis. JAMA Intern Med . 2017;177:1498 –1505 .112.Garrison SR, Kolber MR, Korownyk CS, et al. Blood pressure targets forhypertension in older adults. Cochrane Database Syst Rev . 2017;8:CD011575 .113. Bavishi C, Bangalore S, Messerli FH. Outcomes of intensive bloodpressure lowering in older hypertensive patients.


Instruction: What does Bavishi C, Bangalore S, Messerli FH do in older hypertensive patients?

Output: intensive bloodpressure lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Bavishi C, Bangalore S, Messerli FH do in older hypertensive patients?. ### Response: intensive bloodpressure lowering.


Instruction: What is the UKPDS 38?

Output: UK Prospective Diabetes Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the UKPDS 38?. ### Response: UK Prospective Diabetes Study Group.


Instruction: When did the BMJ issue 317:703–713.115?

Output: 1998

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the BMJ issue 317:703–713.115?. ### Response: 1998.


Instruction: What was the name of the trial investigators that conducted the Syst-Eur trial?

Output: Systolic Hypertension in Europe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the trial investigators that conducted the Syst-Eur trial?. ### Response: Systolic Hypertension in Europe.


Instruction: What is the name of the journal that published in 1997?

Output: Lancet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that published in 1997?. ### Response: Lancet.


Instruction: What type of diabetic patients were studied for albuminuria?

Output: normotensive type 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diabetic patients were studied for albuminuria?. ### Response: normotensive type 2.


Instruction: What trial showed improvements in NYHA class and functional capacity over a short-term exposure?

Output: Assessment in Patients With Iron Deficiency and Chronic Heart Failure)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What trial showed improvements in NYHA class and functional capacity over a short-term exposure?. ### Response: Assessment in Patients With Iron Deficiency and Chronic Heart Failure).