Instruction: How many more structured guidelines are there?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many more structured guidelines are there?. ### Response: 2.


Instruction: What is the abbreviation of the Preamble?

Output: abbreviated version

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the abbreviation of the Preamble?. ### Response: abbreviated version.


Instruction: Who is a member of the ACC/AHA Task Force on Clinical Practice Guidelines?

Output: Glenn N. Levine, MD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a member of the ACC/AHA Task Force on Clinical Practice Guidelines?. ### Response: Glenn N. Levine, MD.


Instruction: What may initially account for theirantihypertensive effect?

Output: salt and water excretion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may initially account for theirantihypertensive effect?. ### Response: salt and water excretion.


Instruction: What may involve direct or indirectvasodilator actions?

Output: salt and water excretion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may involve direct or indirectvasodilator actions?. ### Response: salt and water excretion.


Instruction: What should be considered inpatients at risk of metabolic syndrome?

Output: metabolic side effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered inpatients at risk of metabolic syndrome?. ### Response: metabolic side effects.


Instruction: What are 2 broad groups of thiazide-type diuretics?

Output: Furosemide (also called frusemide), bu-metanide, torsemide and ethacrynic acid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are 2 broad groups of thiazide-type diuretics?. ### Response: Furosemide (also called frusemide), bu-metanide, torsemide and ethacrynic acid.


Instruction: What is used in low doses intreatment of hypertension?

Output: thiazide diuretics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used in low doses intreatment of hypertension?. ### Response: thiazide diuretics.


Instruction: What is the valid compar-ion of low dose thiazide versus?

Output: thiazide-like diuretic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the valid compar-ion of low dose thiazide versus?. ### Response: thiazide-like diuretic.


Instruction: Where have these regimens been compared?

Output: UKNational Institute for Health and Clinical Excellence (NICE)guidelines on primary hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where have these regimens been compared?. ### Response: UKNational Institute for Health and Clinical Excellence (NICE)guidelines on primary hypertension.


Instruction: What did NICE recommend in newly treated primary hypertensives?

Output: thiazide-like diuretics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did NICE recommend in newly treated primary hypertensives?. ### Response: thiazide-like diuretics.


Instruction: Why were the diuretics preferable to thiazides?

Output: larger volume ofevidence for efﬁcacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why were the diuretics preferable to thiazides?. ### Response: larger volume ofevidence for efﬁcacy.


Instruction: What is the relevance of these observations to CKD patients?

Output: unclear

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the relevance of these observations to CKD patients?. ### Response: unclear.


Instruction: What are thiazides excreted by the kidney?

Output: no dose adjustment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are thiazides excreted by the kidney?. ### Response: no dose adjustment.


Instruction: What is no dose adjustment recom-mend in patients with reduced GFR?

Output: thiazides

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is no dose adjustment recom-mend in patients with reduced GFR?. ### Response: thiazides.


Instruction: When the GFR falls below 30–50 ml/min/1.73 m2, the ability of what is diminished?

Output: thiazides

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When the GFR falls below 30–50 ml/min/1.73 m2, the ability of what is diminished?. ### Response: thiazides.


Instruction: What do most clinicians switch to in patients with CKD 4?

Output: aloop diuretic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do most clinicians switch to in patients with CKD 4?. ### Response: aloop diuretic.


Instruction: What is often one of the drug combinations?

Output: Thiazides

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is often one of the drug combinations?. ### Response: Thiazides.


Instruction: What is often one of the first drugs used for BP lowering in CKD?

Output: Thiazides

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is often one of the first drugs used for BP lowering in CKD?. ### Response: Thiazides.


Instruction: What is known to potentiate the effect of other antihypertensive agents?

Output: Thiazides

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is known to potentiate the effect of other antihypertensive agents?. ### Response: Thiazides.


Instruction: What may reduce the risk of hyperkalemia?

Output: Thiazides

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may reduce the risk of hyperkalemia?. ### Response: Thiazides.


Instruction: What is convenient for patients and mayimprove compliance?

Output: The inclusion of thiazides in ﬁxed-dose combinations withother antihypertensives

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is convenient for patients and mayimprove compliance?. ### Response: The inclusion of thiazides in ﬁxed-dose combinations withother antihypertensives.


Instruction: What are the most commonly used loop diuretics?

Output: Furosemide (also called frusemide), bu-metanide, torsemide and ethacrynic acid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the most commonly used loop diuretics?. ### Response: Furosemide (also called frusemide), bu-metanide, torsemide and ethacrynic acid.


Instruction: What is the most common use of loop diuretics?

Output: Furosemide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common use of loop diuretics?. ### Response: Furosemide.


Instruction: In what type of hypertension are loop diurestics more effective than thiazides in the long term?

Output: primary hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what type of hypertension are loop diurestics more effective than thiazides in the long term?. ### Response: primary hypertension.


Instruction: What type of diuretic is particularly useful when treating edema and high BP in CKD 4-5 patients?

Output: Loop diuretics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diuretic is particularly useful when treating edema and high BP in CKD 4-5 patients?. ### Response: Loop diuretics.


Instruction: What is an alternative to thiazide diuretics?

Output: Loop diuretics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an alternative to thiazide diuretics?. ### Response: Loop diuretics.


Instruction: Triamterene and amiloride are what?

Output: Potassium-sparing diuretics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Triamterene and amiloride are what?. ### Response: Potassium-sparing diuretics.


Instruction: What did sitting with 3-minute interruptions of walking or light-intensity activity while standing every 30 minutes decrease SBP by?

Output: 5.0 mm Hg (95% CI, −7 .9 to 2.0) and 4.2 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did sitting with 3-minute interruptions of walking or light-intensity activity while standing every 30 minutes decrease SBP by?. ### Response: 5.0 mm Hg (95% CI, −7 .9 to 2.0) and 4.2 mm Hg.


Instruction: What was the difference between 8 hours of uninterrupted sitting and sitting?

Output: decreased SBP by 5.0 mm Hg (95% CI, −7 .9 to 2.0) and 4.2 mm Hg (95% CI, −7 .2 to −1.3),

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the difference between 8 hours of uninterrupted sitting and sitting?. ### Response: decreased SBP by 5.0 mm Hg (95% CI, −7 .9 to 2.0) and 4.2 mm Hg (95% CI, −7 .2 to −1.3),.


Instruction: How many hours of uninterrupted sitting was observed?

Output: 8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many hours of uninterrupted sitting was observed?. ### Response: 8.


Instruction: What was not observed by condition for diastolic BP or plasma fibrinogen lev-els?

Output: effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not observed by condition for diastolic BP or plasma fibrinogen lev-els?. ### Response: effect.


Instruction: What is a treatment for stroke or TIA?

Output: nicotine replacement, bupropion, or varenicline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a treatment for stroke or TIA?. ### Response: nicotine replacement, bupropion, or varenicline.


Instruction: What is the name of a drug that can be used to help quit smoking?

Output: nicotine replacement, bupropion, or varenicline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of a drug that can be used to help quit smoking?. ### Response: nicotine replacement, bupropion, or varenicline.


Instruction: What should be advised to stop smoking to lower the risk of recurrent stroke?

Output: Patients with stroke or TIA who continue to smoke tobacco

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be advised to stop smoking to lower the risk of recurrent stroke?. ### Response: Patients with stroke or TIA who continue to smoke tobacco.


Instruction: In patients with stroke or TIA, what is recommended to reduce risk?

Output: tobacco smoke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with stroke or TIA, what is recommended to reduce risk?. ### Response: tobacco smoke.


Instruction: What is an independent, potent, and safe method of smoking?

Output: SynopsisCigarette smoking

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an independent, potent, and safe method of smoking?. ### Response: SynopsisCigarette smoking.


Instruction: What is an independent, potent, and dose-respondent risk factor for first ischemic stroke147,151,152 and silent cerebral infarction153?

Output: SynopsisCigarette smoking

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an independent, potent, and dose-respondent risk factor for first ischemic stroke147,151,152 and silent cerebral infarction153?. ### Response: SynopsisCigarette smoking.


Instruction: What has been independently associated with increased risk of stroke and mortality?

Output: Environmental tobacco smoke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been independently associated with increased risk of stroke and mortality?. ### Response: Environmental tobacco smoke.


Instruction: What is tobacco use an addictive behavior?

Output: cessation is difficult

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is tobacco use an addictive behavior?. ### Response: cessation is difficult.


Instruction: What percentage of smokers continue to smoke even after a life-threatening vascular event?

Output: one-third

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of smokers continue to smoke even after a life-threatening vascular event?. ### Response: one-third.


Instruction: Persis-tent cigarette smoking after stroke is associated with increased what?

Output: longer-term mortality rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Persis-tent cigarette smoking after stroke is associated with increased what?. ### Response: longer-term mortality rates.


Instruction: What is the risk of stroke recurrence in persistent smokers compared with nonsmokers143–145?

Output: ≈ 2-fold

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of stroke recurrence in persistent smokers compared with nonsmokers143–145?. ### Response: ≈ 2-fold.


Instruction: Behavioral and pharmacological interventions for tobacco dependence are evidence based through multiple meta-analyses139,140,160 but not in what type of disease popu-lations?

Output: cerebrovascular

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Behavioral and pharmacological interventions for tobacco dependence are evidence based through multiple meta-analyses139,140,160 but not in what type of disease popu-lations?. ### Response: cerebrovascular.


Instruction: No RCTs have examined smoking cessation interventions on what?

Output: recurrent events after stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No RCTs have examined smoking cessation interventions on what?. ### Response: recurrent events after stroke.


Instruction: No RCTs have examined smoking cessation interventions on recurrent events after stroke compared with what?

Output: no intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No RCTs have examined smoking cessation interventions on recurrent events after stroke compared with what?. ### Response: no intervention.


Instruction: What is emerging encouraging evidence of after stroke in mul-tibehavioral interventions?

Output: increased smoking cessation rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is emerging encouraging evidence of after stroke in mul-tibehavioral interventions?. ### Response: increased smoking cessation rates.


Instruction: How long after discharge did intensive counseling in hospital with supportive contacts increase smoking cessa-tion rates compared with usual care?

Output: 1 month

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after discharge did intensive counseling in hospital with supportive contacts increase smoking cessa-tion rates compared with usual care?. ### Response: 1 month.


Instruction: What is the RR of ahajournals.org?

Output: 1.37

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the RR of ahajournals.org?. ### Response: 1.37.


Instruction: How many patients had composite primary outcomes of cardiac death, nonfatal myocardial infarction, or refractory angina?

Output: 21

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had composite primary outcomes of cardiac death, nonfatal myocardial infarction, or refractory angina?. ### Response: 21.


Instruction: What percentage of patients were treated with multivessel primary PCI?

Output: 9%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients were treated with multivessel primary PCI?. ### Response: 9%).


Instruction: HBPM has the advantage of empowering individuals to take ownership of their medical care, hence promoting what?

Output: adherence to therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: HBPM has the advantage of empowering individuals to take ownership of their medical care, hence promoting what?. ### Response: adherence to therapy.


Instruction: What type of research is needed for the CKD population?

Output: research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of research is needed for the CKD population?. ### Response: research.


Instruction: What can be simpli fid?

Output: procedures for standardized BP measurement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be simpli fid?. ### Response: procedures for standardized BP measurement.


Instruction: How long is the rest period for BP measurement?

Output: 1or 2 minutes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the rest period for BP measurement?. ### Response: 1or 2 minutes.


Instruction: What is the optimal interval for repeating ABPM andHBPM among individuals not taking and taking antihy-pertensive medications?

Output: C15

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the optimal interval for repeating ABPM andHBPM among individuals not taking and taking antihy-pertensive medications?. ### Response: C15.


Instruction: What is a BPthreshold of 120 mm Hg instead of?

Output: 140 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a BPthreshold of 120 mm Hg instead of?. ### Response: 140 mm Hg.


Instruction: What is the BPthreshold for hypertension?

Output: 120 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the BPthreshold for hypertension?. ### Response: 120 mm Hg.


Instruction: What are the phenotypes associated with increased risk for CV disease?

Output: “white-coat”hypertension, masked hypertension, the “white-coat ”effect, and masked uncontrolled hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the phenotypes associated with increased risk for CV disease?. ### Response: “white-coat”hypertension, masked hypertension, the “white-coat ”effect, and masked uncontrolled hypertension.


Instruction: How is the cost-effectiveness of ABPM and HBPM assessed?

Output: sepa-rately

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the cost-effectiveness of ABPM and HBPM assessed?. ### Response: sepa-rately.


Instruction: What is the name of the RCT that compares treatment based on ABPM orHBPM versus standardized of fice BP measurements?

Output: C15

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the RCT that compares treatment based on ABPM orHBPM versus standardized of fice BP measurements?. ### Response: C15.


Instruction: What is not treated with white-coat hypertension?

Output: patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not treated with white-coat hypertension?. ### Response: patients.


Instruction: How is treatment of masked un-controlled hypertension treated?

Output: intensifying

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is treatment of masked un-controlled hypertension treated?. ### Response: intensifying.


Instruction: What is the acronym for transcatheter aortic valve implantation?

Output: TAVI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for transcatheter aortic valve implantation?. ### Response: TAVI.


Instruction: What is the name of the anti-fibrinolytic therapy used in cardiac surgery?

Output: tranexamic acid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the anti-fibrinolytic therapy used in cardiac surgery?. ### Response: tranexamic acid.


Instruction: What is another name for Rapidpoint Coag?

Output: Hepcon HMS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for Rapidpoint Coag?. ### Response: Hepcon HMS.


Instruction: In what year was heparin and protamine used?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was heparin and protamine used?. ### Response: 2006.


Instruction: How does Rapidpoint Coag and Hepcon HMS administer heparin?

Output: Comparison ofheparin administration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does Rapidpoint Coag and Hepcon HMS administer heparin?. ### Response: Comparison ofheparin administration.


Instruction: What is a quick anti-Xa-activity-based whole blood coagulationassay for monitoring?

Output: unfractionated heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a quick anti-Xa-activity-based whole blood coagulationassay for monitoring?. ### Response: unfractionated heparin.


Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al.


Instruction: What can be especially helpful in patients with concomitant MR?

Output: hemodynamic exercise testing using Doppler echocardiography or cardiac catheterization or cardiopulmonary exercise testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be especially helpful in patients with concomitant MR?. ### Response: hemodynamic exercise testing using Doppler echocardiography or cardiac catheterization or cardiopulmonary exercise testing.


Instruction: What can be especially helpful in patients with concomitant lung disease?

Output: Hemo-dynamic evaluation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be especially helpful in patients with concomitant lung disease?. ### Response: Hemo-dynamic evaluation.


Instruction: Normal LA pressure and a large transpulmonary gradient suggest pulmonary hypertension that is attrib-utable to what?

Output: lung disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Normal LA pressure and a large transpulmonary gradient suggest pulmonary hypertension that is attrib-utable to what?. ### Response: lung disease.


Instruction: Left ventriculography may also be of what benefit?

Output: diagnostic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Left ventriculography may also be of what benefit?. ### Response: diagnostic.


Instruction: What is echocardiographic-Doppler interrogation of?

Output: the mitral valve measures flow velocity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is echocardiographic-Doppler interrogation of?. ### Response: the mitral valve measures flow velocity.


Instruction: What does echocardiographic-Doppler interrogation of the mitral valve measure?

Output: flow velocity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does echocardiographic-Doppler interrogation of the mitral valve measure?. ### Response: flow velocity.


Instruction: What is used to determine the amount of blood flow from the LV to the LA?

Output: ventriculography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used to determine the amount of blood flow from the LV to the LA?. ### Response: ventriculography.


Instruction: A carefully performed ventriculogram can help in what?

Output: quantifying MR severity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A carefully performed ventriculogram can help in what?. ### Response: quantifying MR severity.


Instruction: What can help in quantifying MR severity?

Output: a carefully performed ventriculogram

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can help in quantifying MR severity?. ### Response: a carefully performed ventriculogram.


Instruction: What can be helpful when resting information is equivocal?

Output: Additional hemodynam-ic interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be helpful when resting information is equivocal?. ### Response: Additional hemodynam-ic interventions.


Instruction: Where are references to studies that support the recommendation summarized?

Output: Online Data Supplement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are references to studies that support the recommendation summarized?. ### Response: Online Data Supplement.


Instruction: What does Online Data Supplement 28.COR LOE Recommendation2a B-NR1 summarize?

Output: studies that support the recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Online Data Supplement 28.COR LOE Recommendation2a B-NR1 summarize?. ### Response: studies that support the recommendation.


Instruction: What is reasonable in patients with primary MR (Stages B and C) and symptoms that might be attributable to MR?

Output: hemodynamic exercise testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable in patients with primary MR (Stages B and C) and symptoms that might be attributable to MR?. ### Response: hemodynamic exercise testing.


Instruction: What is reasonable?

Output: hemodynamic exercise testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable?. ### Response: hemodynamic exercise testing.


Instruction: What can provide additional diagnostic and prognostic information in a subset of apparently asymptomatic patients with severe primary MR?

Output: exercise testing with hemodynamics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can provide additional diagnostic and prognostic information in a subset of apparently asymptomatic patients with severe primary MR?. ### Response: exercise testing with hemodynamics.


Instruction: Exercise testing with hemodynamics can provide what?

Output: additional diagnostic and prognostic information

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Exercise testing with hemodynamics can provide what?. ### Response: additional diagnostic and prognostic information.


Instruction: What can establish true exercise tolerance?

Output: A formal treadmill exercise test

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can establish true exercise tolerance?. ### Response: A formal treadmill exercise test.


Instruction: What can form the base-line for future symptom assessment?

Output: A formal treadmill exercise test

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can form the base-line for future symptom assessment?. ### Response: A formal treadmill exercise test.


Instruction: What can provide additional information about a cardiac or noncardiac limita-tion?

Output: oxygen consumption measurements during exercise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can provide additional information about a cardiac or noncardiac limita-tion?. ### Response: oxygen consumption measurements during exercise.


Instruction: What do patients usually complain of when they complain of symptoms?

Output: dyspnea with exertion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do patients usually complain of when they complain of symptoms?. ### Response: dyspnea with exertion.


Instruction: Exercise echocardiography or exercise invasive hemodynamics may add what?

Output: i-tional prognostic value

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Exercise echocardiography or exercise invasive hemodynamics may add what?. ### Response: i-tional prognostic value.


Instruction: What might echocardiography or exercise invasive hemodynamics add to the prognostic value?

Output: beyond conventional exer -cise treadmill testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What might echocardiography or exercise invasive hemodynamics add to the prognostic value?. ### Response: beyond conventional exer -cise treadmill testing.


Instruction: What may worsen during exercise?

Output: MR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may worsen during exercise?. ### Response: MR.


Instruction: Filling pressures may become markedly abnormal, helping to demon-strate MR as the cause of what?

Output: dyspnea

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Filling pressures may become markedly abnormal, helping to demon-strate MR as the cause of what?. ### Response: dyspnea.


Instruction: What is the cause of the patient’s dyspnea?

Output: noncardiac

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cause of the patient’s dyspnea?. ### Response: noncardiac.


Instruction: What are the recommendations for Medical Therapy for Chronic Primary MR summarized in?

Output: Online Data Supplement 29.COR LOE Recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the recommendations for Medical Therapy for Chronic Primary MR summarized in?. ### Response: Online Data Supplement 29.COR LOE Recommendations.


Instruction: What did Schomig A, Neumann FJ, Kastrati A, et al. do after the placement of coronary-artery stents?

Output: randomized comparison ofantiplatelet and anticoagulant therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Schomig A, Neumann FJ, Kastrati A, et al. do after the placement of coronary-artery stents?. ### Response: randomized comparison ofantiplatelet and anticoagulant therapy.


Instruction: What was a randomized comparison of antiplatelet and anticoagulant therapy after?

Output: the placement of coronary-artery stents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a randomized comparison of antiplatelet and anticoagulant therapy after?. ### Response: the placement of coronary-artery stents.


Instruction: When did BMJ issue 324:71–86.562?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did BMJ issue 324:71–86.562?. ### Response: 2002.


Instruction: What is a risk factor for stroke in high riskpatients?

Output: myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for stroke in high riskpatients?. ### Response: myocardial infarction.


Instruction: What are the AHA/ACC guidelines for sec-ondary prevention for patients with coronary and other atheroscleroticvascular disease?

Output: 2006 Update

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the AHA/ACC guidelines for sec-ondary prevention for patients with coronary and other atheroscleroticvascular disease?. ### Response: 2006 Update.


Instruction: Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials?

Output: Lancet. 2009;373:1849–60.564

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials?. ### Response: Lancet. 2009;373:1849–60.564.


Instruction: When did Gurbel PA, Bliden KP, Zaman KA, et al. publish Clopidogrel loading witheptifibatide to arrest the reactivity of platelets?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Gurbel PA, Bliden KP, Zaman KA, et al. publish Clopidogrel loading witheptifibatide to arrest the reactivity of platelets?. ### Response: 2005.


Instruction: What is CLEARPLATELETS?

Output: ClopidogrelLoading With eptifibatide to Arrest the Reactivity of Platelets

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CLEARPLATELETS?. ### Response: ClopidogrelLoading With eptifibatide to Arrest the Reactivity of Platelets.


Instruction: What is the effect of clopidogrelpretreatment before percutaneous coronary intervention in patients with ST-elevation myocardial infarction treated with fibrinolytics?

Output: long-term therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of clopidogrelpretreatment before percutaneous coronary intervention in patients with ST-elevation myocardial infarction treated with fibrinolytics?. ### Response: long-term therapy.


Instruction: What is clopidogrel used for in the prevention of myocardialdamage after elective stent implantation?

Output: pre-treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is clopidogrel used for in the prevention of myocardialdamage after elective stent implantation?. ### Response: pre-treatment.


Instruction: What is the difference between prasugrel and clopi-dogrel?

Output: acute coronary syndromes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between prasugrel and clopi-dogrel?. ### Response: acute coronary syndromes.


Instruction: What is clopi-dogrel used for in patients with acute coronary syndromes?

Output: Prasugrel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is clopi-dogrel used for in patients with acute coronary syndromes?. ### Response: Prasugrel.


Instruction: What is the difference between clopidogrel and ticagrelor?

Output: acute coronary syndromes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between clopidogrel and ticagrelor?. ### Response: acute coronary syndromes.


Instruction: How many patients have been treated with aspirinin?

Output: 45 852

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients have been treated with aspirinin?. ### Response: 45 852.


Instruction: How many patients with acute myocardial infarction were treated with clopidogrel and aspirinin?

Output: 45 852

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with acute myocardial infarction were treated with clopidogrel and aspirinin?. ### Response: 45 852.


Instruction: What is the name of the study that evaluated the effects of pretreatment with a combination of aspiridin and ciscogine on patients undergoing percutaneous coronary intervention?

Output: PCI-CURE study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated the effects of pretreatment with a combination of aspiridin and ciscogine on patients undergoing percutaneous coronary intervention?. ### Response: PCI-CURE study.


Instruction: What is the PCI-CURE study?

Output: Effects of pretreatment withclopidogrel and aspirin followed by long-term therapy in patientsundergoing percutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the PCI-CURE study?. ### Response: Effects of pretreatment withclopidogrel and aspirin followed by long-term therapy in patientsundergoing percutaneous coronary intervention.


Instruction: What are the long-term outcomes of clopidogrelduration and stent type in a diabetic population with de novo coronaryartery lesions?

Output: Long-term outcomes by clopidogrelduration and stent type in a diabetic population with de novo coronaryartery lesions. J Am Coll Cardiol. 2008;51:2220–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the long-term outcomes of clopidogrelduration and stent type in a diabetic population with de novo coronaryartery lesions?. ### Response: Long-term outcomes by clopidogrelduration and stent type in a diabetic population with de novo coronaryartery lesions. J Am Coll Cardiol. 2008;51:2220–.


Instruction: When was the J Am Coll Cardiol.51:2220–7.572?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol.51:2220–7.572?. ### Response: 2008.


Instruction: What is the name of the randomized controlled trial of oral antiplatelet therapy following percutaneous coronary intervention?

Output: PCI-CURE study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized controlled trial of oral antiplatelet therapy following percutaneous coronary intervention?. ### Response: PCI-CURE study.


Instruction: When was the JAMA's 288:2411–20.573 published?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the JAMA's 288:2411–20.573 published?. ### Response: 2002.


Instruction: What was the 8th edition of the AmericanCollege of Chest Physicians Evidence-Based Clinical PracticeGuidelines?

Output: Antiplatelet drugs: AmericanCollege of Chest Physicians Evidence-Based Clinical PracticeGuidelines (8th edition). Chest. 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 8th edition of the AmericanCollege of Chest Physicians Evidence-Based Clinical PracticeGuidelines?. ### Response: Antiplatelet drugs: AmericanCollege of Chest Physicians Evidence-Based Clinical PracticeGuidelines (8th edition). Chest. 2008.


Instruction: What age group did the retrospective analysis cover?

Output: 60

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What age group did the retrospective analysis cover?. ### Response: 60.


Instruction: When was this retrospective analysis released?

Output: April 23, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this retrospective analysis released?. ### Response: April 23, 2023.


Instruction: How much of the usual dose of enoxaparin is given to CrCl patients?

Output: 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the usual dose of enoxaparin is given to CrCl patients?. ### Response: 50%.


Instruction: What is the usual dosage of LMWH?

Output: 1 mg/kg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the usual dosage of LMWH?. ### Response: 1 mg/kg.


Instruction: When given in prophylactic doses, what is the effect on the cardiovascular system?

Output: LMWH has not been shown to increase the risk of bleeding complica-tions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When given in prophylactic doses, what is the effect on the cardiovascular system?. ### Response: LMWH has not been shown to increase the risk of bleeding complica-tions.


Instruction: What has not been shown to increase the risk of bleeding complica-tions?

Output: drug accumulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has not been shown to increase the risk of bleeding complica-tions?. ### Response: drug accumulation.


Instruction: What was found in patients with renal failure who received repeated once-daily prophylactic doses of enoxaparin?

Output: higher anti-Xa levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was found in patients with renal failure who received repeated once-daily prophylactic doses of enoxaparin?. ### Response: higher anti-Xa levels.


Instruction: What was the mean peak anti-Xa level?

Output: 0.6 units/mL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean peak anti-Xa level?. ### Response: 0.6 units/mL.


Instruction: How many units/mL was the trough?

Output: 0.2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many units/mL was the trough?. ### Response: 0.2.


Instruction: What was no increased bleeding observed?

Output: aparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was no increased bleeding observed?. ### Response: aparin.


Instruction: What was not observed in a study of critically ill patients with a wide range of renal function?

Output: dalteparin bioaccu-mulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not observed in a study of critically ill patients with a wide range of renal function?. ### Response: dalteparin bioaccu-mulation.


Instruction: What was given daily to consec-utive ICU patients?

Output: subcutaneous dalteparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was given daily to consec-utive ICU patients?. ### Response: subcutaneous dalteparin.


Instruction: How many International Units was dalteparin given to?

Output: 5,000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many International Units was dalteparin given to?. ### Response: 5,000.


Instruction: How many International Units were given daily to consec-utive ICU patients?

Output: 5,000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many International Units were given daily to consec-utive ICU patients?. ### Response: 5,000.


Instruction: How much creatinine clearance did the patients have?

Output: 30 mL/min

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much creatinine clearance did the patients have?. ### Response: 30 mL/min.


Instruction: What was the risk of bleeding increased?

Output: no evidence of drug accumulation nor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk of bleeding increased?. ### Response: no evidence of drug accumulation nor.


Instruction: What is the recommended dose of enoxaparin for CrCl patients?

Output: 30 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommended dose of enoxaparin for CrCl patients?. ### Response: 30 mg.


Instruction: How many units of tinzaparin were used once daily in a small comparative study?

Output: 4,500

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many units of tinzaparin were used once daily in a small comparative study?. ### Response: 4,500.


Instruction: How long did it take for enoxaparin to bioaccumulate?

Output: 8 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for enoxaparin to bioaccumulate?. ### Response: 8 days.


Instruction: What was seen in 8 days of exposure?

Output: bioaccumulation of enoxaparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was seen in 8 days of exposure?. ### Response: bioaccumulation of enoxaparin.


Instruction: For other LMWHs, dosing recommendations cannot be made in the setting of what?

Output: renal insufﬁ  ciency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For other LMWHs, dosing recommendations cannot be made in the setting of what?. ### Response: renal insufﬁ  ciency.


Instruction: What is there no proven method for neutralizing LMWH?

Output: protamine sulfate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is there no proven method for neutralizing LMWH?. ### Response: protamine sulfate.


Instruction: Studies in vitro and in animals have demon-strated that protamine sulfate neutralizes the anti-IIa activity of what?

Output: LMWH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Studies in vitro and in animals have demon-strated that protamine sulfate neutralizes the anti-IIa activity of what?. ### Response: LMWH.


Instruction: What neutralizes a variable portion of the anti-Xa activity of LMWH?

Output: protamine sulfate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What neutralizes a variable portion of the anti-Xa activity of LMWH?. ### Response: protamine sulfate.


Instruction: Protamine does not bind to what?

Output: LMWH fragments

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Protamine does not bind to what?. ### Response: LMWH fragments.


Instruction: What does sulfate neutralize?

Output: anti-IIa activity of LMWH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does sulfate neutralize?. ### Response: anti-IIa activity of LMWH.


Instruction: What are LMWH preparations that have low sulfate charge density?

Output: LMWH fragments

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are LMWH preparations that have low sulfate charge density?. ### Response: LMWH fragments.


Instruction: What is the clinical signifi cce of incomplete anti-Xa neutralization?

Output: unclear

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the clinical signifi cce of incomplete anti-Xa neutralization?. ### Response: unclear.


Instruction: How many patients have clinical bleeding associated with LMWH?

Output: three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients have clinical bleeding associated with LMWH?. ### Response: three.


Instruction: How many of the 169 patients have bleeding associated?

Output: three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many of the 169 patients have bleeding associated?. ### Response: three.


Instruction: What is there no human studies that demonstrate or refute a benefi cial effect of protamine sulfate on?

Output: © 2012 American College of Chest Physicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is there no human studies that demonstrate or refute a benefi cial effect of protamine sulfate on?. ### Response: © 2012 American College of Chest Physicians.


Instruction: What is the name of the book written by Kimberly Henricks?

Output: American College of Chest Physicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the book written by Kimberly Henricks?. ### Response: American College of Chest Physicians.


Instruction: When was chestjournal.chestpubs.org released?

Output: February 10, 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was chestjournal.chestpubs.org released?. ### Response: February 10, 2012.


Instruction: What was more effective in reducing BP in the valsartan group?

Output: amlodipine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was more effective in reducing BP in the valsartan group?. ### Response: amlodipine.


Instruction: What was a strong trend for an excess risk of stroke?

Output: amlodipine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a strong trend for an excess risk of stroke?. ### Response: amlodipine.


Instruction: Which group had the same BP differential that favored amlodipine?

Output: valsartan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which group had the same BP differential that favored amlodipine?. ### Response: valsartan.


Instruction: What drug was favored by amlodipine?

Output: BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug was favored by amlodipine?. ### Response: BP.


Instruction: What was the goal of aggressive BP control in high-risk hypertensive patients?

Output: frequently requires combina-tion therapy at the outset

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the goal of aggressive BP control in high-risk hypertensive patients?. ### Response: frequently requires combina-tion therapy at the outset.


Instruction: Who supported the idea of combina-tion therapy at the outset?

Output: Blood Pressure Lowering Treatment Trialists’ Collaboration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who supported the idea of combina-tion therapy at the outset?. ### Response: Blood Pressure Lowering Treatment Trialists’ Collaboration.


Instruction: What should be prescribed to all CAD patients with stable angina who also have hypertension, diabetes mellitus, an LV ejection fraction 40% or CKD?

Output: Angiotensin Receptor BlockersARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be prescribed to all CAD patients with stable angina who also have hypertension, diabetes mellitus, an LV ejection fraction 40% or CKD?. ### Response: Angiotensin Receptor BlockersARBs.


Instruction: What did the HOPE study do?

Output: high-risk individuals, 80% of whom had CAD, were given an ACE inhibitor (ramipril 10 mg/d), with a reduction in CVD end points by 20% to 25%;

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the HOPE study do?. ### Response: high-risk individuals, 80% of whom had CAD, were given an ACE inhibitor (ramipril 10 mg/d), with a reduction in CVD end points by 20% to 25%;.


Instruction: What percentage of CAD patients were given an ACE inhibitor?

Output: 80%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of CAD patients were given an ACE inhibitor?. ### Response: 80%.


Instruction: What percentage of high-risk individuals had CAD?

Output: 80%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of high-risk individuals had CAD?. ### Response: 80%.


Instruction: What was the ACE inhibitor used for?

Output: management of patients with stable CAD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the ACE inhibitor used for?. ### Response: management of patients with stable CAD.


Instruction: How much was the reduction in CVD end points?

Output: 20% to 25%;

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much was the reduction in CVD end points?. ### Response: 20% to 25%;.


Instruction: EUROPA showed a 20% relative risk reduction in what end point?

Output: primary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: EUROPA showed a 20% relative risk reduction in what end point?. ### Response: primary.


Instruction: What is the dose of perindopril versus placebo?

Output: 8 mg/d

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the dose of perindopril versus placebo?. ### Response: 8 mg/d.


Instruction: What are some studies that have had negative results?

Output: PEACE,106

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some studies that have had negative results?. ### Response: PEACE,106.


Instruction: PEACE,106 showed what type of LV function in patients with stable CAD?

Output: normal or slightly reduced

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: PEACE,106 showed what type of LV function in patients with stable CAD?. ### Response: normal or slightly reduced.


Instruction: What is the target dose of trandolapril?

Output: 4 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the target dose of trandolapril?. ### Response: 4 mg.


Instruction: What was found to not be a difference between the groups in the incidence of the primary composite end point of cardiovascular death, MI, or coronary revascularization?

Output: Patients in the PEACE trial were at lower risk and were receiving more aggressive secondary prevention therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was found to not be a difference between the groups in the incidence of the primary composite end point of cardiovascular death, MI, or coronary revascularization?. ### Response: Patients in the PEACE trial were at lower risk and were receiving more aggressive secondary prevention therapy.


Instruction: Who was at lower risk for coronary revascularization in the PEACE trial?

Output: Patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was at lower risk for coronary revascularization in the PEACE trial?. ### Response: Patients.


Instruction: Who was receiving more aggressive secondary prevention therapy?

Output: Patients in the PEACE trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was receiving more aggressive secondary prevention therapy?. ### Response: Patients in the PEACE trial.


Instruction: What percent of participants in the ALLHAT trial had CAD?

Output: 25%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percent of participants in the ALLHAT trial had CAD?. ### Response: 25%.


Instruction: What was the primary outcome of the study?

Output: nonfa-tal MI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary outcome of the study?. ### Response: nonfa-tal MI.


Instruction: What is combined CAD plus coronary revascularization or hos-pitalization for angina?

Output: the primary outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is combined CAD plus coronary revascularization or hos-pitalization for angina?. ### Response: the primary outcome.


Instruction: What was the name of the study that reported the results of a prospective, open-label study in patients 65 to 84 years of age with hypertension?

Output: Second Australian National Blood Pressure Study (ANBP-2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the study that reported the results of a prospective, open-label study in patients 65 to 84 years of age with hypertension?. ### Response: Second Australian National Blood Pressure Study (ANBP-2.


Instruction: What did the study show in men but not in women?

Output: better cardiovascular outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the study show in men but not in women?. ### Response: better cardiovascular outcomes.


Instruction: What is better for women with ACE inhibitors than with diuretic agents?

Output: cardiovascular outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is better for women with ACE inhibitors than with diuretic agents?. ### Response: cardiovascular outcomes.


Instruction: What are Angiotensin Receptor Blockers recommended for all patients with stable angina?

Output: ARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are Angiotensin Receptor Blockers recommended for all patients with stable angina?. ### Response: ARBs.


Instruction: Who published the 2018 Cholesterol Clinical Practice Guidelines?

Output: Grundy et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2018 Cholesterol Clinical Practice Guidelines?. ### Response: Grundy et al.


Instruction: When did Grundy and colleagues publish the 2018 CHOLESTEOLOGICAL PRACTICE GUIDELINES?

Output: June 18/25, 2019

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Grundy and colleagues publish the 2018 CHOLESTEOLOGICAL PRACTICE GUIDELINES?. ### Response: June 18/25, 2019.


Instruction: What is the name of the randomized controlled trial of myocardial infarction?

Output: IDEAL study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized controlled trial of myocardial infarction?. ### Response: IDEAL study.


Instruction: Where can you find the FDA Approved Drug Products?

Output: https://www.accessdata.fda.gov/scripts/  cder/daf/

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find the FDA Approved Drug Products?. ### Response: https://www.accessdata.fda.gov/scripts/  cder/daf/.


Instruction: What is Rosuvastatin to prevent in men and women with elevated C-reactive pro-tein?

Output: vascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Rosuvastatin to prevent in men and women with elevated C-reactive pro-tein?. ### Response: vascular events.


Instruction: What is the name of the randomised trial of cholesterol lowering in 4444 patients with coro-nary heart disease?

Output: Scandinavian Simvastatin Survival Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised trial of cholesterol lowering in 4444 patients with coro-nary heart disease?. ### Response: Scandinavian Simvastatin Survival Study.


Instruction: How many patients with coro-nary heart disease were included in the Scandinavian Simvastatin Survival Study (4S)?

Output: 4444

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with coro-nary heart disease were included in the Scandinavian Simvastatin Survival Study (4S)?. ### Response: 4444.


Instruction: What is the name of the study that examined cholesterol lowering in 4444 patients?

Output: Scandinavian Simvastatin Survival Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined cholesterol lowering in 4444 patients?. ### Response: Scandinavian Simvastatin Survival Study.


Instruction: When was the Lancet 344:1383-9?

Output: 1994

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Lancet 344:1383-9?. ### Response: 1994.


Instruction: How is lovastatin used to prevent acute coronary events?

Output: Primary prevention of acute coronary events with lovastatin in men and women with average cho-lesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is lovastatin used to prevent acute coronary events?. ### Response: Primary prevention of acute coronary events with lovastatin in men and women with average cho-lesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study.


Instruction: What is the Air Force/Texas Coronary Atherosclerosis Prevention Study?

Output: AFCAPS/TexCAPS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Air Force/Texas Coronary Atherosclerosis Prevention Study?. ### Response: AFCAPS/TexCAPS.


Instruction: What is pravastatin's effect on coronary events after myocardial infarction in patients with average cholesterol levels?

Output: death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is pravastatin's effect on coronary events after myocardial infarction in patients with average cholesterol levels?. ### Response: death.


Instruction: Cholesterol and Recurrent Events Trial. 1996;335:1001–9.

Output: patients with average cholesterol levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cholesterol and Recurrent Events Trial. 1996;335:1001–9.. ### Response: patients with average cholesterol levels.


Instruction: What is pravastatin used for in men with hypercholesterolemia?

Output: Prevention of coronary heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is pravastatin used for in men with hypercholesterolemia?. ### Response: Prevention of coronary heart disease.


Instruction: What is the West of Scotland Coronary Prevention Study Group?

Output: Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the West of Scotland Coronary Prevention Study Group?. ### Response: Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia.


Instruction: When did N Engl J Med 333:1301-7?

Output: 1995

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did N Engl J Med 333:1301-7?. ### Response: 1995.


Instruction: What is pravastatin used for in patients with coronary heart disease and a broad range of initial cholesterol levels?

Output: Prevention of cardiovascular events and death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is pravastatin used for in patients with coronary heart disease and a broad range of initial cholesterol levels?. ### Response: Prevention of cardiovascular events and death.


Instruction: What is the name of the MRC/BHF Heart Protection Study in 20 536 high-risk individuals?

Output: MRC/BHF Heart Protection Study of antioxidant vitamin supple-mentation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the MRC/BHF Heart Protection Study in 20 536 high-risk individuals?. ### Response: MRC/BHF Heart Protection Study of antioxidant vitamin supple-mentation.


Instruction: How many high-risk individuals were enrolled in a randomised placebo-controlled trial?

Output: 20 536

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many high-risk individuals were enrolled in a randomised placebo-controlled trial?. ### Response: 20 536.


Instruction: What is the name of the trial that involved 20 536 high risk individuals?

Output: MRC/BHF Heart Protection Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the trial that involved 20 536 high risk individuals?. ### Response: MRC/BHF Heart Protection Study.


Instruction: When was the trial conducted?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the trial conducted?. ### Response: 2006.


Instruction: How many people were included in the study?

Output: 20 536

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were included in the study?. ### Response: 20 536.


Instruction: What is the difference between intensive versus moderate lipid lowering with statins after acute coronary syndromes?

Output: Intensive versus mod-erate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between intensive versus moderate lipid lowering with statins after acute coronary syndromes?. ### Response: Intensive versus mod-erate.


Instruction: What is atorvastatin used for in patients with stable coronary disease?

Output: Intensive lipid lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is atorvastatin used for in patients with stable coronary disease?. ### Response: Intensive lipid lowering.


Instruction: In what year did N Engl J Med issue 350:1495-504.

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did N Engl J Med issue 350:1495-504.. ### Response: 2004.


Instruction: What is pravastatin used for in Japan?

Output: Primary prevention of car -diovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is pravastatin used for in Japan?. ### Response: Primary prevention of car -diovascular disease.


Instruction: What is the MEGA Study?

Output: a pro-spective randomised controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the MEGA Study?. ### Response: a pro-spective randomised controlled trial.


Instruction: In what year was MEGA study conducted?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was MEGA study conducted?. ### Response: 2006.


Instruction: What is the name of the study that investigated the effect of cholesterol lowering in people with cardiovascular disease?

Output: Scandinavian Simvastatin Survival Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the effect of cholesterol lowering in people with cardiovascular disease?. ### Response: Scandinavian Simvastatin Survival Study.


Instruction: What was the N Engl J Med 2016:374:2021-31?

Output: Cholesterol lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the N Engl J Med 2016:374:2021-31?. ### Response: Cholesterol lowering.


Instruction: What is a marker of reversibility of pulmonary vascular resistance?

Output: pulmonary vasodilator therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a marker of reversibility of pulmonary vascular resistance?. ### Response: pulmonary vasodilator therapy.


Instruction: What are “Treat-to-repair” strategies involving use of PAH therapies?

Output: bring pulmonary vascular resistance into a range where repair can be considered have been applied

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are “Treat-to-repair” strategies involving use of PAH therapies?. ### Response: bring pulmonary vascular resistance into a range where repair can be considered have been applied.


Instruction: What has been applied to bring pulmonary vascular resistance into a range where repair can be considered?

Output: PAH therapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been applied to bring pulmonary vascular resistance into a range where repair can be considered?. ### Response: PAH therapies.


Instruction: What is the ACHD AP classification system?

Output: anatomic and physiological

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ACHD AP classification system?. ### Response: anatomic and physiological.


Instruction: What is the acronym for adult congenital heart disease?

Output: ACHD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for adult congenital heart disease?. ### Response: ACHD.


Instruction: What does ASD stand for?

Output: atrial septal defect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ASD stand for?. ### Response: atrial septal defect.


Instruction: CCT stands for what?

Output: cardiac computed tomography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: CCT stands for what?. ### Response: cardiac computed tomography.


Instruction: IE stands for infective endocarditis.

Output: IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: IE stands for infective endocarditis.. ### Response: IE.


Instruction: What is PR stands for?

Output: pulmonary regurgitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PR stands for?. ### Response: pulmonary regurgitation.


Instruction: What is RV?

Output: right ventricle

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is RV?. ### Response: right ventricle.


Instruction: What is TGA?

Output: transposition of the great arteries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is TGA?. ### Response: transposition of the great arteries.


Instruction: WHAT is VSD?

Output: ventricular septal defect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: WHAT is VSD?. ### Response: ventricular septal defect.


Instruction: What is the risk of sinus node dysfunction after the Mustard, Senning, Glenn, or Fontan procedure?

Output: sinus bradycardia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of sinus node dysfunction after the Mustard, Senning, Glenn, or Fontan procedure?. ### Response: sinus bradycardia.


Instruction: What type of tachycardia is seen in patients who have had atriotomy?

Output: intra-atrial re-entry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of tachycardia is seen in patients who have had atriotomy?. ### Response: intra-atrial re-entry.


Instruction: Atrioventricular block in patients at risk for progression of what?

Output: atri

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atrioventricular block in patients at risk for progression of what?. ### Response: atri.


Instruction: What is used to evaluate rhythm in patients with pacemakers?

Output: ECGs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used to evaluate rhythm in patients with pacemakers?. ### Response: ECGs.


Instruction: What is measured in patients after repair of TOF and as part of CRT evaluation?

Output: QRS duration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is measured in patients after repair of TOF and as part of CRT evaluation?. ### Response: QRS duration.


Instruction: To compare with postoperative ECGs in patients undergoing heart surgery and noncardiac surgery?

Output: Preoperatively

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: To compare with postoperative ECGs in patients undergoing heart surgery and noncardiac surgery?. ### Response: Preoperatively.


Instruction: Postoperatively to identify what arrhythmias?

Output: atrial ectopic tachycardia, atrial flutter, AF, junctional ectopic tachycardia, atrioventricular block

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Postoperatively to identify what arrhythmias?. ### Response: atrial ectopic tachycardia, atrial flutter, AF, junctional ectopic tachycardia, atrioventricular block.


Instruction: What is Wolff-Parkinson-White syndrome in patients with Ebstein anomaly?

Output: Diagnosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Wolff-Parkinson-White syndrome in patients with Ebstein anomaly?. ### Response: Diagnosis.


Instruction: What indicates adult congenital heart disease?

Output: ACHD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates adult congenital heart disease?. ### Response: ACHD.


Instruction: What is CRT?

Output: cardiac resynchronization therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CRT?. ### Response: cardiac resynchronization therapy.


Instruction: What is ECG?

Output: electrocardiogram

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ECG?. ### Response: electrocardiogram.


Instruction: Tof is tetralogy of what?

Output: Fallot

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Tof is tetralogy of what?. ### Response: Fallot.


Instruction: What is a possible cause of RV volume and pressure overload?

Output: systemic right ventricles

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a possible cause of RV volume and pressure overload?. ### Response: systemic right ventricles.


Instruction: What type of aneurysms can be assessed with a serial assessment?

Output: thoracic aortic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of aneurysms can be assessed with a serial assessment?. ### Response: thoracic aortic.


Instruction: What is relatively safe when performed in a controlled manner by experienced operators?

Output: ergonovine, acetylcholine, methylergonovine)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is relatively safe when performed in a controlled manner by experienced operators?. ### Response: ergonovine, acetylcholine, methylergonovine).


Instruction: What can happen very infrequently?

Output: sustained spasm, serious arrhythmias, and even death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can happen very infrequently?. ### Response: sustained spasm, serious arrhythmias, and even death.


Instruction: Provocative testing should be avoided in patients with what?

Output: significant left main disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Provocative testing should be avoided in patients with what?. ### Response: significant left main disease.


Instruction: What is the main disease?

Output: left

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the main disease?. ### Response: left.


Instruction: What are the presence of high-grade obstructive lesions?

Output: advanced 3-vessel disease, presence of high-grade obstructive lesions, significant valvular stenosis, significant LV systolic dysfunction, and advanced HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the presence of high-grade obstructive lesions?. ### Response: advanced 3-vessel disease, presence of high-grade obstructive lesions, significant valvular stenosis, significant LV systolic dysfunction, and advanced HF.


Instruction: Who published the 2018 Cholesterol Clinical Practice Guidelines?

Output: Grundy et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2018 Cholesterol Clinical Practice Guidelines?. ### Response: Grundy et al.


Instruction: When did Grundy publish the 2018 ACC/AHA focused update of secondary prevention lipid performance?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Grundy publish the 2018 ACC/AHA focused update of secondary prevention lipid performance?. ### Response: 2015.


Instruction: What was the focus of the 2015 ACC/AHA focused update of secondary prevention lipid performance measures?

Output: a report of the American College of Cardiology/American Heart Association Task Force on Performance Measures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the focus of the 2015 ACC/AHA focused update of secondary prevention lipid performance measures?. ### Response: a report of the American College of Cardiology/American Heart Association Task Force on Performance Measures.


Instruction: What did the American College of Cardiology/American Heart Association Task Force on Performance Measures report on?

Output: secondary prevention lipid performance measures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the American College of Cardiology/American Heart Association Task Force on Performance Measures report on?. ### Response: secondary prevention lipid performance measures.


Instruction: When did Circ Cardiovasc Qual Outcomes publish?

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circ Cardiovasc Qual Outcomes publish?. ### Response: 2016.


Instruction: What is the name of the randomized controlled trial that examined absolute cardiovascular dis-ease risk and shared decision making in primary care?

Output: ASCVD Risk Estimator Plus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized controlled trial that examined absolute cardiovascular dis-ease risk and shared decision making in primary care?. ### Response: ASCVD Risk Estimator Plus.


Instruction: What is available at: http://tools.acc.org/ASCVD-Risk-Estimator-Plus/#!/calculate/estimate/?

Output: ASCVD Risk Estimator Plus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is available at: http://tools.acc.org/ASCVD-Risk-Estimator-Plus/#!/calculate/estimate/?. ### Response: ASCVD Risk Estimator Plus.


Instruction: Where is Statin Choice Decision Aid available?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Statin Choice Decision Aid available?. ### Response: https://statindecisionaid.mayoclinic.org/..


Instruction: What is the pinnacle of patient-centered care?

Output: Shared decision making

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the pinnacle of patient-centered care?. ### Response: Shared decision making.


Instruction: What year did N Engl J Med publish 366:780–1?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did N Engl J Med publish 366:780–1?. ### Response: 2012.


Instruction: Who wrote a systematic review of shared decision making and patient outcomes?

Output: Shay LA, Lafata JE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote a systematic review of shared decision making and patient outcomes?. ### Response: Shay LA, Lafata JE.


Instruction: What is Motivational Interviewing to Create Change?

Output: pharmacistsletter.therapeuticresearch.com/(X(1)S(0wvsds30  xqejdo551cdariq1))/ce/cecourse.aspx

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Motivational Interviewing to Create Change?. ### Response: pharmacistsletter.therapeuticresearch.com/(X(1)S(0wvsds30  xqejdo551cdariq1))/ce/cecourse.aspx.


Instruction: Where can you find motivational interviewing to create change?

Output: Available at: http://  pharmacistsletter.therapeuticresearch.com/(X(1)S(0wvsds30  xqejdo551cdariq1))/ce/cecourse.aspx

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find motivational interviewing to create change?. ### Response: Available at: http://  pharmacistsletter.therapeuticresearch.com/(X(1)S(0wvsds30  xqejdo551cdariq1))/ce/cecourse.aspx.


Instruction: What are the economic value considerations of PCSK9?

Output: policy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the economic value considerations of PCSK9?. ### Response: policy.


Instruction: What did the American College of Cardiology/American Heart Association Task Force on Performance Measures and Practice Guidelines state-ment on?

Output: cost/value methodology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the American College of Cardiology/American Heart Association Task Force on Performance Measures and Practice Guidelines state-ment on?. ### Response: cost/value methodology.


Instruction: What was the name of the task force on performance measures and practice guidelines?

Output: American College of Cardiology/American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the task force on performance measures and practice guidelines?. ### Response: American College of Cardiology/American Heart Association.


Instruction: When did Circulation. 2014;129:2329-45.

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circulation. 2014;129:2329-45.. ### Response: 2014.


Instruction: What is Evolocumab and clini-cal outcomes in patients with cardiovascular disease?

Output: Cost-effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Evolocumab and clini-cal outcomes in patients with cardiovascular disease?. ### Response: Cost-effectiveness.


Instruction: What is the N Engl J Med. 2017;376:1713–22?

Output: Evolocumab and clini-cal outcomes in patients with cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the N Engl J Med. 2017;376:1713–22?. ### Response: Evolocumab and clini-cal outcomes in patients with cardiovascular disease.


Instruction: Hlatky MA, Kazi DS. What is economics and policy?

Output: PCSK9 Inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hlatky MA, Kazi DS. What is economics and policy?. ### Response: PCSK9 Inhibitors.


Instruction: How many participants participated in a prospective meta-analysis of data from 14 randomised trials of statins?

Output: 90 056

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many participants participated in a prospective meta-analysis of data from 14 randomised trials of statins?. ### Response: 90 056.


Instruction: What is the name of the study that evaluated the efficacy and safety of cholesterol-lowering treatment?

Output: Grundy et al 2018 Cholesterol Clinical Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated the efficacy and safety of cholesterol-lowering treatment?. ### Response: Grundy et al 2018 Cholesterol Clinical Practice Guidelines.


Instruction: When was the Lancet 366:1267–78.

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Lancet 366:1267–78.. ### Response: 2005.


Instruction: What was the cost-effectiveness of evo-locumab therapy?

Output: Cost-effectiveness of evo-locumab therapy for reducing cardiovascular events in patients with ath -erosclerotic cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the cost-effectiveness of evo-locumab therapy?. ### Response: Cost-effectiveness of evo-locumab therapy for reducing cardiovascular events in patients with ath -erosclerotic cardiovascular disease.


Instruction: What does ath -erosclerotic cardiovascular disease cause?

Output: reducing cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ath -erosclerotic cardiovascular disease cause?. ### Response: reducing cardiovascular events.


Instruction: What does JAMA Cardiol. 2017:2:1069-78.

Output: Cost-effectiveness of evo-locumab therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does JAMA Cardiol. 2017:2:1069-78.. ### Response: Cost-effectiveness of evo-locumab therapy.


Instruction: What is a quantitative approach to determining when to add nonstatin therapy?

Output: Cost-effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a quantitative approach to determining when to add nonstatin therapy?. ### Response: Cost-effectiveness.


Instruction: What year did vasc Surg. 2017154:1371–8.e1?

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did vasc Surg. 2017154:1371–8.e1?. ### Response: 2017.


Instruction: When was this document downloaded?

Output: April 27, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this document downloaded?. ### Response: April 27, 2023.


Instruction: What type of stenosis does the catheter cardiovasc interv. 2008:71:944-9?

Output: mitral and aortic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of stenosis does the catheter cardiovasc interv. 2008:71:944-9?. ### Response: mitral and aortic.


Instruction: Dobutamine stress echocardiog-raphy for noninvasive assessment and risk stratification of patients with rheumatic mitral stenosis?

Output: 5. Reis G

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Dobutamine stress echocardiog-raphy for noninvasive assessment and risk stratification of patients with rheumatic mitral stenosis?. ### Response: 5. Reis G.


Instruction: What is the value of the mitral valve resistance?

Output: Value of the mitral valve resistance in evaluation of symptomatic patients with mild and moderate mitral ste-nosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the value of the mitral valve resistance?. ### Response: Value of the mitral valve resistance in evaluation of symptomatic patients with mild and moderate mitral ste-nosis.


Instruction: What is the value of the mitral valve resistance in evaluation of symptomatic patients with mild and moderate mitral ste-nosis?

Output: exercise tolerance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the value of the mitral valve resistance in evaluation of symptomatic patients with mild and moderate mitral ste-nosis?. ### Response: exercise tolerance.


Instruction: Echocardiography. 2014;31:347–52.6.2.2. What are the outcomes of direct oral anticoagulants in patients with withral stenosis called?

Output: Medical Therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Echocardiography. 2014;31:347–52.6.2.2. What are the outcomes of direct oral anticoagulants in patients with withral stenosis called?. ### Response: Medical Therapy.


Instruction: How many patients with mitral stenosis have a natural history of DOACs?

Output: 271

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with mitral stenosis have a natural history of DOACs?. ### Response: 271.


Instruction: What type of anticoagulants are used in patients with atrial fibrillation?

Output: heart rate control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of anticoagulants are used in patients with atrial fibrillation?. ### Response: heart rate control.


Instruction: Who is the author of the study?

Output: Olesen KH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of the study?. ### Response: Olesen KH.


Instruction: When is the time for a randomized clinical trial?

Output: 2019;73:1132–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is the time for a randomized clinical trial?. ### Response: 2019;73:1132–.


Instruction: How many patients with mitral stenosis under medical treatment did Olesen KH have?

Output: 271

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with mitral stenosis under medical treatment did Olesen KH have?. ### Response: 271.


Instruction: How many years did Rowe JC, Bland EF, Sprague HB, et al. have without surgery?

Output: ten- and twenty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many years did Rowe JC, Bland EF, Sprague HB, et al. have without surgery?. ### Response: ten- and twenty.