Instruction: Who is the Content Reviewer?

Output: Brian R. Lindman

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Content Reviewer?. ### Response: Brian R. Lindman.


Instruction: What is the name of the committee that reviews clinical practice guidelines?

Output: Joint Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the committee that reviews clinical practice guidelines?. ### Response: Joint Committee.


Instruction: What is the name of the group that reviewed the guidelines?

Output: Joint Committee on Clinical Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that reviewed the guidelines?. ### Response: Joint Committee on Clinical Practice Guidelines.


Instruction: What is NIH's affiliation with the NGS Predict Study?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NIH's affiliation with the NGS Predict Study?. ### Response: None.


Instruction: What is the name of the NGS Predict Study?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the NGS Predict Study?. ### Response: None.


Instruction: What is another name for the NIH?

Output: The NGS Predict Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for the NIH?. ### Response: The NGS Predict Study.


Instruction: What imaging results can affect therapy decisions in hyperacute stroke care?

Output: Magnetic resonance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What imaging results can affect therapy decisions in hyperacute stroke care?. ### Response: Magnetic resonance.


Instruction: What is the name of the group that collaborated with North American Symptomatic Carotid Endarterectomy Trial Collaborators?

Output: PROGRESS Collaborative Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that collaborated with North American Symptomatic Carotid Endarterectomy Trial Collaborators?. ### Response: PROGRESS Collaborative Group.


Instruction: What is the benefit of carotid endarterectomy in symptomatic patients with high-grade stenosis?

Output: Beneficial effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the benefit of carotid endarterectomy in symptomatic patients with high-grade stenosis?. ### Response: Beneficial effect.


Instruction: When was the N Engl J Med 325:445-453?

Output: 1991

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the N Engl J Med 325:445-453?. ### Response: 1991.


Instruction: What was the final result of the MRC ECST?

Output: Randomised trial of endarterectomy for recently symptomatic carotid stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the final result of the MRC ECST?. ### Response: Randomised trial of endarterectomy for recently symptomatic carotid stenosis.


Instruction: What was the name of the MRC European Carotid Surgery Trial?

Output: ECST

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the MRC European Carotid Surgery Trial?. ### Response: ECST.


Instruction: When was the ECST published?

Output: 1998

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the ECST published?. ### Response: 1998.


Instruction: What did SPARCL stand for?

Output: Stroke Prevention by Aggressive Reduction in Cholesterol Levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did SPARCL stand for?. ### Response: Stroke Prevention by Aggressive Reduction in Cholesterol Levels.


Instruction: What does SPARCL stand for?

Output: Stroke Prevention by Aggressive Reduction in Cholesterol Levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does SPARCL stand for?. ### Response: Stroke Prevention by Aggressive Reduction in Cholesterol Levels.


Instruction: What is atorvastatin used for after a stroke or transient ischemic attack?

Output: High-dose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is atorvastatin used for after a stroke or transient ischemic attack?. ### Response: High-dose.


Instruction: When did the N Engl J Med issue 355:549-559?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the N Engl J Med issue 355:549-559?. ### Response: 2006.


Instruction: How did the European Stroke Prevention Study compare dipyridamole and acetylsalicylic acid?

Output: 2: dipyridamole and acetylsalicylic acid in the secondary prevention of stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did the European Stroke Prevention Study compare dipyridamole and acetylsalicylic acid?. ### Response: 2: dipyridamole and acetylsalicylic acid in the secondary prevention of stroke.


Instruction: What is acetylsalicylic acid in the secondary prevention of?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is acetylsalicylic acid in the secondary prevention of?. ### Response: stroke.


Instruction: What is the name of the randomised, blinded trial of clopido-grel versus aspirin in patients at risk of ischaemic events?

Output: CAPRIE Steering Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised, blinded trial of clopido-grel versus aspirin in patients at risk of ischaemic events?. ### Response: CAPRIE Steering Committee.


Instruction: What is clopido-grel versus for recurrent stroke?

Output: Aspirin and extended-release dipyridamole

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is clopido-grel versus for recurrent stroke?. ### Response: Aspirin and extended-release dipyridamole.


Instruction: What is the name of the study group that studied aspirin and extended-release dipyridamole?

Output: PRoFESS Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study group that studied aspirin and extended-release dipyridamole?. ### Response: PRoFESS Study Group.


Instruction: When was the N Engl J Med published?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the N Engl J Med published?. ### Response: 2008.


Instruction: What is the name of the Swedish Aspirin Low-Dose Trial?

Output: SALT Collaborative Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Swedish Aspirin Low-Dose Trial?. ### Response: SALT Collaborative Group.


Instruction: What is a secondary prophylaxis after cerebrovascular ischaemic events?

Output: Swedish Aspirin Low-Dose Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a secondary prophylaxis after cerebrovascular ischaemic events?. ### Response: Swedish Aspirin Low-Dose Trial.


Instruction: How many people were in a randomised trial of a perindopril-based blood pressure-lowering regimen?

Output: 6,105

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were in a randomised trial of a perindopril-based blood pressure-lowering regimen?. ### Response: 6,105.


Instruction: How many strokes were there in 2001?

Output: 358:1033–1041

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes were there in 2001?. ### Response: 358:1033–1041.


Instruction: What is the name of the journal that published a systematic review of the impact of MRI on stroke management and outcomes?

Output: J Eval Clin Pract.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that published a systematic review of the impact of MRI on stroke management and outcomes?. ### Response: J Eval Clin Pract..


Instruction: When did J Eval Clin Pract publish its systematic review?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J Eval Clin Pract publish its systematic review?. ### Response: 2013.


Instruction: What is the name of the study that evaluated the cost-effectiveness of magnetic resonance in patients with transient ischaemic attack and minor stroke?

Output: a systematic review, meta-analysis and economic evaluation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated the cost-effectiveness of magnetic resonance in patients with transient ischaemic attack and minor stroke?. ### Response: a systematic review, meta-analysis and economic evaluation.


Instruction: What does diffusion-weighted imaging include?

Output: cost-effectiveness of magnetic resonance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does diffusion-weighted imaging include?. ### Response: cost-effectiveness of magnetic resonance.


Instruction: What ischaemic attack and minor stroke: a systematic review, meta-analysis and economic evaluation?

Output: transient

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What ischaemic attack and minor stroke: a systematic review, meta-analysis and economic evaluation?. ### Response: transient.


Instruction: What did Health Technol Assess. 2014;18:1–368, v–vi?

Output: An assessment of the cost-effectiveness of magnetic resonance, including diffusion-weighted imaging, in patients with transient ischaemic attack and minor stroke: a systematic review, meta-analysis and economic evaluation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Health Technol Assess. 2014;18:1–368, v–vi?. ### Response: An assessment of the cost-effectiveness of magnetic resonance, including diffusion-weighted imaging, in patients with transient ischaemic attack and minor stroke: a systematic review, meta-analysis and economic evaluation.


Instruction: How many economic evaluations were included in this review?

Output: Five

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many economic evaluations were included in this review?. ### Response: Five.


Instruction: What is a GP who has completed a course for special interest registration?

Output: healthcare professionals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a GP who has completed a course for special interest registration?. ### Response: healthcare professionals.


Instruction: What economic evaluation compared an MDT to usual care?

Output: Five

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What economic evaluation compared an MDT to usual care?. ### Response: Five.


Instruction: How long did a mid -length MDT clinic last?

Output: 3-6 month

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did a mid -length MDT clinic last?. ### Response: 3-6 month.


Instruction: What was included in this review?

Output: Five relevant economic evaluations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was included in this review?. ### Response: Five relevant economic evaluations.


Instruction: What is the length of a home based MDT clinic?

Output: 3-6 month

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the length of a home based MDT clinic?. ### Response: 3-6 month.


Instruction: What is a cardiologist, heart failure nurse, palliative care physician and physiotherapist?

Output: home -based MDT clinic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a cardiologist, heart failure nurse, palliative care physician and physiotherapist?. ### Response: home -based MDT clinic.


Instruction: What are patients with a previous stroke or TIA at higher risk for during CABG than those without ahistory?

Output: aperioperative stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients with a previous stroke or TIA at higher risk for during CABG than those without ahistory?. ### Response: aperioperative stroke.


Instruction: What is the perioperative stroke risk of 8.5% in patients with previous stroke compared to 2.2% in those without prior stroke?

Output: P/H110210.0001

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the perioperative stroke risk of 8.5% in patients with previous stroke compared to 2.2% in those without prior stroke?. ### Response: P/H110210.0001.


Instruction: How much increased perioperative risk was present in patients with previous stroke compared with patients without a previous neurological event?

Output: 2.2%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much increased perioperative risk was present in patients with previous stroke compared with patients without a previous neurological event?. ### Response: 2.2%.


Instruction: How many patients with a history of stroke or TIA were analyzed separately?

Output: 860

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with a history of stroke or TIA were analyzed separately?. ### Response: 860.


Instruction: In a multivariate logistic regressionanalysis of 16 194 patients, what was the increase in risk incomparison?

Output: neurologically asymptomatic patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In a multivariate logistic regressionanalysis of 16 194 patients, what was the increase in risk incomparison?. ### Response: neurologically asymptomatic patients.


Instruction: How many cardiac surgery patients had a history ofcerebrovascular disease?

Output: 16 194

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many cardiac surgery patients had a history ofcerebrovascular disease?. ### Response: 16 194.


Instruction: What was identified as an independent predictor of perioperative stroke in a multivariate logistic regression analysis of 16 194 patients?

Output: a history ofcerebrovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was identified as an independent predictor of perioperative stroke in a multivariate logistic regression analysis of 16 194 patients?. ### Response: a history ofcerebrovascular disease.


Instruction: The STS National Car-diac Surgery Database demonstrated an increased risk of what?

Output: perioperative death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The STS National Car-diac Surgery Database demonstrated an increased risk of what?. ### Response: perioperative death.


Instruction: When did patients with a history of stroke undergo isolated CABG?

Output: 2002 to 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did patients with a history of stroke undergo isolated CABG?. ### Response: 2002 to 2006.


Instruction: What is PADCAD and PAD generally defined as?

Output: atherosclerotic diseaseof the aorta

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PADCAD and PAD generally defined as?. ### Response: atherosclerotic diseaseof the aorta.


Instruction: The presence of PAD is what?

Output: an independent predictor of early1241and late death in CABG patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The presence of PAD is what?. ### Response: an independent predictor of early1241and late death in CABG patients.


Instruction: What is an independent predictor of early1241and late death in CABG patients?

Output: PAD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an independent predictor of early1241and late death in CABG patients?. ### Response: PAD.


Instruction: In the STS National CardiacSurgery Database, how many patients underwent isolatedCABG over a 5-year period?

Output: 774 881

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the STS National CardiacSurgery Database, how many patients underwent isolatedCABG over a 5-year period?. ### Response: 774 881.


Instruction: What was an independent risk factor for in-hospital death or death within 30 days of CABG?

Output: PAD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was an independent risk factor for in-hospital death or death within 30 days of CABG?. ### Response: PAD.


Instruction: What was PAD independent risk for perioperative strokeand subsequent need for post-CABG limb revascularization or amputation?

Output: death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was PAD independent risk for perioperative strokeand subsequent need for post-CABG limb revascularization or amputation?. ### Response: death.


Instruction: What may the presence of PAD lead to?

Output: vascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may the presence of PAD lead to?. ### Response: vascular events.


Instruction: What may PAD be a marker for?

Output: more severe CAD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may PAD be a marker for?. ### Response: more severe CAD.


Instruction: What may contribute to noncardiovascular death in the long term?

Output: PAD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may contribute to noncardiovascular death in the long term?. ### Response: PAD.


Instruction: What is not known toimprove post-CABG outcomes?

Output: Revascularization of PAD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not known toimprove post-CABG outcomes?. ### Response: Revascularization of PAD.


Instruction: How much is the annual hospital cost of CABG in the US?

Output: $10 billion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much is the annual hospital cost of CABG in the US?. ### Response: $10 billion.


Instruction: What is the annual cost of CABG?

Output: $10 billion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the annual cost of CABG?. ### Response: $10 billion.


Instruction: What is CABG becoming more cost-effective?

Output: increasing risk profile of CABG candidates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CABG becoming more cost-effective?. ### Response: increasing risk profile of CABG candidates.


Instruction: How many patients had isolated CABG in the United States from 1988 to 2005?

Output: 5.5 million

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had isolated CABG in the United States from 1988 to 2005?. ### Response: 5.5 million.


Instruction: What was the decrease in risk-adjusted mortal-ity rate from 6.2% to 2.1%?

Output: P/H110210.0001

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the decrease in risk-adjusted mortal-ity rate from 6.2% to 2.1%?. ### Response: P/H110210.0001.


Instruction: When werehospital costs corrected for inflation?

Output: 1988

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When werehospital costs corrected for inflation?. ### Response: 1988.


Instruction: How much did the cost of CABG decrease in 1988?

Output: $26 210

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much did the cost of CABG decrease in 1988?. ### Response: $26 210.


Instruction: What does Tullus K say about angiotensin II receptor blockers in preschoolchildren?

Output: Safety concerns

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Tullus K say about angiotensin II receptor blockers in preschoolchildren?. ### Response: Safety concerns.


Instruction: What does Simonetti GD, Santoro L, Ferrarini A, et al. say about systemic hypertension andproteinuria in childhood chronic renal parenchymal disease?

Output: role ofantihypertensive drug management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Simonetti GD, Santoro L, Ferrarini A, et al. say about systemic hypertension andproteinuria in childhood chronic renal parenchymal disease?. ### Response: role ofantihypertensive drug management.


Instruction: What year did Paediatr Drugs publish a report on hypertension in children with kidneydisease?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Paediatr Drugs publish a report on hypertension in children with kidneydisease?. ### Response: 2007.


Instruction: What is the name of the multicenter study of thepharmacokinetics of lisinopril?

Output: pilot study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multicenter study of thepharmacokinetics of lisinopril?. ### Response: pilot study.


Instruction: What is the name of the study that found that hypertensive patients respond differently to benazepril?

Output: Anhui HypertensionHealth Care Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that found that hypertensive patients respond differently to benazepril?. ### Response: Anhui HypertensionHealth Care Study.


Instruction: What year did the Anhui HypertensionHealth Care Study take place?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did the Anhui HypertensionHealth Care Study take place?. ### Response: 2004.


Instruction: What is the name of the double-blind, placebo-controlled, dose-response study of lisinopril for children with hypertension?

Output: Am J Hypertens

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the double-blind, placebo-controlled, dose-response study of lisinopril for children with hypertension?. ### Response: Am J Hypertens.


Instruction: What was the title of the study that examined the effectiveness and safety of enalapril?

Output: a pilot study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the title of the study that examined the effectiveness and safety of enalapril?. ### Response: a pilot study.


Instruction: What is the pharmacokinetics of enalapril in children and infants with hypertension?

Output: Antiproteinuric effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the pharmacokinetics of enalapril in children and infants with hypertension?. ### Response: Antiproteinuric effects.


Instruction: What is Ellis D, Moritz ML, Vats A et al.?

Output: Antihypertensive and renoprotectiveefﬁcacy and safety of losartan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Ellis D, Moritz ML, Vats A et al.?. ### Response: Antihypertensive and renoprotectiveefﬁcacy and safety of losartan.


Instruction: What is the name of the long-term study in children with renaldisorders?

Output: Am J Hypertens

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the long-term study in children with renaldisorders?. ### Response: Am J Hypertens.


Instruction: What does bradykinin do to cardiovascularmodeling in renovascular hypertensive rats?

Output: Effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does bradykinin do to cardiovascularmodeling in renovascular hypertensive rats?. ### Response: Effects.


Instruction: What type of renovascular hypertensive rat has been modelled?

Output: proteinuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of renovascular hypertensive rat has been modelled?. ### Response: proteinuria.


Instruction: What is the name of the disease that causes proteinuria to be associated with race and kidney disease?

Output: chronic kidney disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease that causes proteinuria to be associated with race and kidney disease?. ### Response: chronic kidney disease.


Instruction: What is the cause of chronic kidney disease in children study?

Output: Systemic hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cause of chronic kidney disease in children study?. ### Response: Systemic hypertension.


Instruction: What was the glomerular filtration rate in the study in children?

Output: 363– 371.341

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the glomerular filtration rate in the study in children?. ### Response: 363– 371.341.


Instruction: How did angiotensin II antagonist compare to dihydropyridine calciumchannel blocker?

Output: Better renoprotectiveeffect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did angiotensin II antagonist compare to dihydropyridine calciumchannel blocker?. ### Response: Better renoprotectiveeffect.


Instruction: What is the effect of enalapril and losartan on the kidney?

Output: Antiproteinuric effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of enalapril and losartan on the kidney?. ### Response: Antiproteinuric effects.


Instruction: What is a side effect of angiotensin-converting enzyme inhibitor plus a calciumchannel blocker?

Output: Better renoprotectiveeffect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a side effect of angiotensin-converting enzyme inhibitor plus a calciumchannel blocker?. ### Response: Better renoprotectiveeffect.


Instruction: What is the main effect of angiotensin-converting enzyme inhibitor on children with proteinuria?

Output: Renal and cardiovascular

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the main effect of angiotensin-converting enzyme inhibitor on children with proteinuria?. ### Response: Renal and cardiovascular.


Instruction: What is a reappraisal of Europeanguidelines on hypertension management: a European Society of Hypertension Task Force document?

Output: Mancia G, Laurent S, Agabiti-Rosei E et al.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a reappraisal of Europeanguidelines on hypertension management: a European Society of Hypertension Task Force document?. ### Response: Mancia G, Laurent S, Agabiti-Rosei E et al..


Instruction: Where is Online Data Supplement 29.COR LOE Recommendations2a B-NR1 summarized?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Online Data Supplement 29.COR LOE Recommendations2a B-NR1 summarized?. ### Response: http://ahajournals.org.


Instruction: What is reasonable in symptomatic or asymptomatic patients with severe primary MR and LV systolic dysfunction?

Output: GDMT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable in symptomatic or asymptomatic patients with severe primary MR and LV systolic dysfunction?. ### Response: GDMT.


Instruction: What is dysfunction reasonable?

Output: GDMT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is dysfunction reasonable?. ### Response: GDMT.


Instruction: What is not indicated in patients with primary MR and normal LV systolic function?

Output: vasodilator therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not indicated in patients with primary MR and normal LV systolic function?. ### Response: vasodilator therapy.


Instruction: What is evidence that vasodilator therapy reduces MR severity?

Output: little or no clinically important ben-efit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is evidence that vasodilator therapy reduces MR severity?. ### Response: little or no clinically important ben-efit.


Instruction: What should be implemented as in any patient with LV systolic dysfunction or systemic hypertension?

Output: GDMT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be implemented as in any patient with LV systolic dysfunction or systemic hypertension?. ### Response: GDMT.


Instruction: Patients with MR and LV dysfunction experience what?

Output: myocardial damage and HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with MR and LV dysfunction experience what?. ### Response: myocardial damage and HF.


Instruction: What is usually indicated in patients with LV systolic dysfunction?

Output: surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is usually indicated in patients with LV systolic dysfunction?. ### Response: surgery.


Instruction: What may be helpful to treat the LV dysfunction alone?

Output: medical therapy for systolic dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be helpful to treat the LV dysfunction alone?. ### Response: medical therapy for systolic dysfunction.


Instruction: What is the standard regimen for HF?

Output: beta-adrenergic blockade, ACE inhibitors or ARBs, and possibly aldosterone antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the standard regimen for HF?. ### Response: beta-adrenergic blockade, ACE inhibitors or ARBs, and possibly aldosterone antagonists.


Instruction: What are the best data available for the use of?

Output: beta blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the best data available for the use of?. ### Response: beta blockers.


Instruction: Beta blockers reverse what in experimental MR?

Output: LV dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Beta blockers reverse what in experimental MR?. ### Response: LV dysfunction.


Instruction: Patients receiving beta blockers may have better surgical outcomes and delayed onset of what?

Output: LV dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients receiving beta blockers may have better surgical outcomes and delayed onset of what?. ### Response: LV dysfunction.


Instruction: ACE inhibition has not been effective in what type of MR with LV dysfunction?

Output: experimental

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ACE inhibition has not been effective in what type of MR with LV dysfunction?. ### Response: experimental.


Instruction: Why is aldosterone antagonism thought to work in part by inhibiting fibrosis?

Output: its role in MR, where little fibrosis occurs, is unclear

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is aldosterone antagonism thought to work in part by inhibiting fibrosis?. ### Response: its role in MR, where little fibrosis occurs, is unclear.


Instruction: Why is vasodilator therapy efficacious in acute severe symptomatic MR?

Output: to forestall the need for surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is vasodilator therapy efficacious in acute severe symptomatic MR?. ### Response: to forestall the need for surgery.


Instruction: What is it rea-sonable to try to forestall the need for surgery?

Output: vasodilator therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is it rea-sonable to try to forestall the need for surgery?. ### Response: vasodilator therapy.


Instruction: What has the limited number of trials addressing afterload reduction shown?

Output: little or no clinically important ben-efit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has the limited number of trials addressing afterload reduction shown?. ### Response: little or no clinically important ben-efit.


Instruction: What do vasodilators decrease in LV size and mitral closing force?

Output: they may increase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do vasodilators decrease in LV size and mitral closing force?. ### Response: they may increase.


Instruction: On what date will ahajournals.org be available?

Output: April 27, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On what date will ahajournals.org be available?. ### Response: April 27, 2023.


Instruction: How many sets of blood tests did the UK study consist of?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many sets of blood tests did the UK study consist of?. ### Response: 2.


Instruction: What was the name of the study that included the costs of the blood test?

Output: UK study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the study that included the costs of the blood test?. ### Response: UK study.


Instruction: How many sets of blood tests did the trial consist of?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many sets of blood tests did the trial consist of?. ### Response: 2.


Instruction: How many hospital appointments with a consultant were there?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many hospital appointments with a consultant were there?. ### Response: 2.


Instruction: What was assumed to be the same as standard care?

Output: monitoring costs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was assumed to be the same as standard care?. ### Response: monitoring costs.


Instruction: What was assumed in the Irish study?

Output: 1 extra outpatient visit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was assumed in the Irish study?. ### Response: 1 extra outpatient visit.


Instruction: How many additional outpatient visits were assumed?

Output: 4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many additional outpatient visits were assumed?. ### Response: 4.


Instruction: What is spironolactone still worth?

Output: highly cost -effective

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is spironolactone still worth?. ### Response: highly cost -effective.


Instruction: How many additional outpatient visits were assumed that spironolactone is still highly cost -effective?

Output: 4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many additional outpatient visits were assumed that spironolactone is still highly cost -effective?. ### Response: 4.


Instruction: The committee agreed that MRAs should be offered to chronic heart failure patients with reduced ejection who remain symptomatic on what current first line?

Output: therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committee agreed that MRAs should be offered to chronic heart failure patients with reduced ejection who remain symptomatic on what current first line?. ### Response: therapy.


Instruction: What should be part of shared decision making in heart failure?

Output: the introduction and continuation of MRAs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be part of shared decision making in heart failure?. ### Response: the introduction and continuation of MRAs.


Instruction: What did the committee consider?

Output: current practice regarding the prescribing of MRAs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee consider?. ### Response: current practice regarding the prescribing of MRAs.


Instruction: What did a lay committee member raise the issue of?

Output: polypharmacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a lay committee member raise the issue of?. ### Response: polypharmacy.


Instruction: What could be discontinued if a person's heart function improves significantly?

Output: one or more of medications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could be discontinued if a person's heart function improves significantly?. ### Response: one or more of medications.


Instruction: How many medications could be discontinued?

Output: one or more

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many medications could be discontinued?. ### Response: one or more.


Instruction: What is the burden of polypharmacy?

Output: not take more medications than required

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the burden of polypharmacy?. ### Response: not take more medications than required.


Instruction: There are no large scale trials addressing this question so what is lacking?

Output: evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There are no large scale trials addressing this question so what is lacking?. ### Response: evidence.


Instruction: What is lacking in this regard?

Output: evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is lacking in this regard?. ### Response: evidence.


Instruction: What should healthcare professionals ensu re that patients are on?

Output: appropriate polypharmacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should healthcare professionals ensu re that patients are on?. ### Response: appropriate polypharmacy.


Instruction: The reduction or removal of particular medications has been noted to lead to what?

Output: deterioration of heart function and risk of arrhythm ia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The reduction or removal of particular medications has been noted to lead to what?. ### Response: deterioration of heart function and risk of arrhythm ia.


Instruction: What is the risk of arrhythmia?

Output: deterioration of heart function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of arrhythmia?. ### Response: deterioration of heart function.


Instruction: What should the decision to discontinue therapies be made on an individual patient basis?

Output: as part of shared decision with the patient as part of the wider multi -disciplinary team

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should the decision to discontinue therapies be made on an individual patient basis?. ### Response: as part of shared decision with the patient as part of the wider multi -disciplinary team.


Instruction: Who discussed current practice regarding the prescribing of MRAs and the potential impact of their recommendation?

Output: The committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who discussed current practice regarding the prescribing of MRAs and the potential impact of their recommendation?. ### Response: The committee.


Instruction: In the 2010 guideline, what can be 'considered' as one of a kind?

Output: MRAs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the 2010 guideline, what can be 'considered' as one of a kind?. ### Response: MRAs.


Instruction: In the 2010 guideline, what can be considered as one of several second line treatment options?

Output: MRAs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the 2010 guideline, what can be considered as one of several second line treatment options?. ### Response: MRAs.


Instruction: What is stronger than the previous recommendation on the use of MRAs?

Output: The new recommendati

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is stronger than the previous recommendation on the use of MRAs?. ### Response: The new recommendati.


Instruction: The suggestion to seek specialist advice prior to introduction has what?

Output: been removed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The suggestion to seek specialist advice prior to introduction has what?. ### Response: been removed.


Instruction: Why has the suggestion to seek specialist advice been removed?

Output: strengthening of the evidence base

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why has the suggestion to seek specialist advice been removed?. ### Response: strengthening of the evidence base.


Instruction: The strengthening of the evidence base and the recognition of local variation in the evidence are what?

Output: The new recommendati on is stronger than the previous recommendation on the use of MRAs (‘offer’ rather than ‘consider’) and the suggestion to seek specialist advice prior to introduction has been removed. This is due to the strengthening of the evidence base and the recogniti on

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The strengthening of the evidence base and the recognition of local variation in the evidence are what?. ### Response: The new recommendati on is stronger than the previous recommendation on the use of MRAs (‘offer’ rather than ‘consider’) and the suggestion to seek specialist advice prior to introduction has been removed. This is due to the strengthening of the evidence base and the recogniti on.


Instruction: How many studies involved repeated BNP or NT -proBNP biomarker testing?

Output: All

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies involved repeated BNP or NT -proBNP biomarker testing?. ### Response: All.


Instruction: What were some algorithms aiming for?

Output: a personal target best on percentage drop of levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were some algorithms aiming for?. ### Response: a personal target best on percentage drop of levels.


Instruction: What was compared against cl inical monitoring in the other study arm?

Output: Treatment algorithms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was compared against cl inical monitoring in the other study arm?. ### Response: Treatment algorithms.


Instruction: What was the usual care with routine cardiac imaging, troponin, or combinations of different biomarkers identified?

Output: No relevant studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the usual care with routine cardiac imaging, troponin, or combinations of different biomarkers identified?. ### Response: No relevant studies.


Instruction: What was included in the review?

Output: Summary of  systematic review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was included in the review?. ### Response: Summary of  systematic review.


Instruction: What is the population included data for Troughton 2014338?

Output: Brunner -la rocca  201555

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the population included data for Troughton 2014338?. ### Response: Brunner -la rocca  201555.


Instruction: What was the median age for HFpEF 77.2 (9.3)?

Output: 72.6 (10.7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the median age for HFpEF 77.2 (9.3)?. ### Response: 72.6 (10.7.


Instruction: How long did the NP-guided therapy last?

Output: 36 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the NP-guided therapy last?. ### Response: 36 months.


Instruction: How many studies were included in IPD: BATTLESCARRED?

Output: Berger 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were included in IPD: BATTLESCARRED?. ### Response: Berger 2010.


Instruction: What is the HFpEF arm of TIME -CHF included in?

Output: Brunner La Rocca

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the HFpEF arm of TIME -CHF included in?. ### Response: Brunner La Rocca.


Instruction: What is the ACEi/ARB angiotensin converting enzyme inhibitor and/or Aldosterone receptor blocker?

Output: ACEi/ARB: Angiotensin converting enzyme inhibitor and/or Aldosterone receptor blocker, BB: Beta -blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ACEi/ARB angiotensin converting enzyme inhibitor and/or Aldosterone receptor blocker?. ### Response: ACEi/ARB: Angiotensin converting enzyme inhibitor and/or Aldosterone receptor blocker, BB: Beta -blocker.


Instruction: What is BB: Beta -blocker, IV: Intravenous therapy?

Output: Angiotensin converting enzyme inhibitor and/or Aldosterone receptor blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is BB: Beta -blocker, IV: Intravenous therapy?. ### Response: Angiotensin converting enzyme inhibitor and/or Aldosterone receptor blocker.


Instruction: What type of studies were included in the review?

Output: primary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of studies were included in the review?. ### Response: primary.


Instruction: Where were primary studies included?

Output: in HF clinic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where were primary studies included?. ### Response: in HF clinic.


Instruction: What was the BATTLESCARRED trial called?

Output: Lainchbury 2009189

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the BATTLESCARRED trial called?. ### Response: Lainchbury 2009189.


Instruction: How long was therapy increased to meet clinical and NP target?

Output: 36 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was therapy increased to meet clinical and NP target?. ### Response: 36 months.


Instruction: How long did therapy increase to meet NP and clinical targets?

Output: 36 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did therapy increase to meet NP and clinical targets?. ### Response: 36 months.


Instruction: What was the mean age of patients who received no protocol?

Output: 18

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean age of patients who received no protocol?. ### Response: 18.


Instruction: How old was the primary care population?

Output: Age > 18

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old was the primary care population?. ### Response: Age > 18.


Instruction: What was the mean age of primary care n=122?

Output: 18

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean age of primary care n=122?. ### Response: 18.


Instruction: HF-admission LVEF40%: 63% Elevated what?

Output: NP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: HF-admission LVEF40%: 63% Elevated what?. ### Response: NP.


Instruction: What is the risk of ASCVD 10%?

Output: <10%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of ASCVD 10%?. ### Response: <10%,.


Instruction: What should be considered in the setting of medication intolerance?

Output: allowing a defined period of time to evaluate the effects of lifestyle mod-ification

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered in the setting of medication intolerance?. ### Response: allowing a defined period of time to evaluate the effects of lifestyle mod-ification.


Instruction: How long does it take to evaluate the effects of lifestyle mod-ification in patients with low CVD risk?

Output: 10-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take to evaluate the effects of lifestyle mod-ification in patients with low CVD risk?. ### Response: 10-year.


Instruction: What is a risk estimater for CVD?

Output: ASCVD Risk Estimator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk estimater for CVD?. ### Response: ASCVD Risk Estimator.


Instruction: What is an assessment of BP levels?

Output: sched-uled follow-up visits

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an assessment of BP levels?. ### Response: sched-uled follow-up visits.


Instruction: How does the Risk Estimator compare to other risk estimates?

Output: 10-year risk of ASCVD <10%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does the Risk Estimator compare to other risk estimates?. ### Response: 10-year risk of ASCVD <10%,.


Instruction: What is BP (SBP or DBP >20 or >10 mm Hg above target) usually downloaded from?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is BP (SBP or DBP >20 or >10 mm Hg above target) usually downloaded from?. ### Response: http://ahajournals.org.


Instruction: When is medication usually Downloaded from http://ahajournals.org?

Output: May 3, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is medication usually Downloaded from http://ahajournals.org?. ### Response: May 3, 2023.


Instruction: Who were the Investigators of the Randomized Aldactone Evaluation Study?

Output: Fox K, Ford I, Steg PG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who were the Investigators of the Randomized Aldactone Evaluation Study?. ### Response: Fox K, Ford I, Steg PG.


Instruction: When was the N Engl J Med published?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the N Engl J Med published?. ### Response: 2008.


Instruction: What was the effect of angiotensin-converting enzyme inhibitors on mortality and morbidity?

Output: Overview of randomized trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the effect of angiotensin-converting enzyme inhibitors on mortality and morbidity?. ### Response: Overview of randomized trials.


Instruction: What type of association does XPNPEP2 C-2399A polymorphism have with angiotensin-converting enzyme inhibitor-associated angioedema?

Output: Sex-dependent and race-dependent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of association does XPNPEP2 C-2399A polymorphism have with angiotensin-converting enzyme inhibitor-associated angioedema?. ### Response: Sex-dependent and race-dependent.


Instruction: What is the name of the drug used in patients at high risk for vascular events?

Output: Telmisartan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used in patients at high risk for vascular events?. ### Response: Telmisartan.


Instruction: What is telmisartan an angiotensin-receptor blocker used for?

Output: vascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is telmisartan an angiotensin-receptor blocker used for?. ### Response: vascular events.


Instruction: What is the name of the Novartis drug Entresto?

Output: Novartis Pharmaceuticals Corporation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Novartis drug Entresto?. ### Response: Novartis Pharmaceuticals Corporation.


Instruction: How many people are at high risk for cardiovascular events?

Output: 145

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people are at high risk for cardiovascular events?. ### Response: 145.


Instruction: What is the name of the trial that compares omapatrilat and enalapril in patients with chronic heart failure?

Output: Omapatrilat Versus Enalapril Randomized Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the trial that compares omapatrilat and enalapril in patients with chronic heart failure?. ### Response: Omapatrilat Versus Enalapril Randomized Trial.


Instruction: When did the OVERTURE Randomized Trial of Utility in Reducing Events take place?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the OVERTURE Randomized Trial of Utility in Reducing Events take place?. ### Response: 2002.


Instruction: What is the acronym for Utility in Reducing Events?

Output: OVERTURE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Utility in Reducing Events?. ### Response: OVERTURE.


Instruction: What does OVERTURE stand for?

Output: Omapatrilat Versus Enalapril Randomized Trial of Utility in Reducing Events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does OVERTURE stand for?. ### Response: Omapatrilat Versus Enalapril Randomized Trial of Utility in Reducing Events.


Instruction: When was the OCTAVE trial conducted?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the OCTAVE trial conducted?. ### Response: 2004.


Instruction: What is a combination of neprilysin and renin- angiotensin system inhibition for the treatment of?

Output: heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a combination of neprilysin and renin- angiotensin system inhibition for the treatment of?. ### Response: heart failure.


Instruction: What is the J Am Coll Cardiol HF. 2014;2:663-70?

Output: Combined neprilysin and renin- angiotensin system inhibition

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the J Am Coll Cardiol HF. 2014;2:663-70?. ### Response: Combined neprilysin and renin- angiotensin system inhibition.


Instruction: Messerli FH, Nussberger J. Vasopeptidase inhibition and what?

Output: angio-oedema

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Messerli FH, Nussberger J. Vasopeptidase inhibition and what?. ### Response: angio-oedema.


Instruction: What is a receptor antagonist-neprilysin inhibitor in the treatment of?

Output: heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a receptor antagonist-neprilysin inhibitor in the treatment of?. ### Response: heart failure.


Instruction: Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and what else?

Output: neprilysin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and what else?. ### Response: neprilysin.


Instruction: What was a randomised, double-blind, placebo-controlled, active comparator study?

Output: Blood-pressure reduction with LCZ696

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a randomised, double-blind, placebo-controlled, active comparator study?. ### Response: Blood-pressure reduction with LCZ696.


Instruction: What is the name of the randomised, double-blind, placebo-controlled, active com-parator study?

Output: BEAUTIFUL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised, double-blind, placebo-controlled, active com-parator study?. ### Response: BEAUTIFUL.


Instruction: When was the Lancet 375:1255-66 published?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Lancet 375:1255-66 published?. ### Response: 2010.


Instruction: What did Bohm M, Robertson M, Ford I, et al. do?

Output: Influence of cardiovascular and non-cardiovascular co-morbidities on outcomes and treatment effect of heart rate reduction with ivabradine in stable heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Bohm M, Robertson M, Ford I, et al. do?. ### Response: Influence of cardiovascular and non-cardiovascular co-morbidities on outcomes and treatment effect of heart rate reduction with ivabradine in stable heart failure.


Instruction: What is the name of the randomised placebo-controlled study of Ivabradine and outcomes in chronic heart failure?

Output: SHIFT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised placebo-controlled study of Ivabradine and outcomes in chronic heart failure?. ### Response: SHIFT.


Instruction: What does SHIFT stand for?

Output: chronic heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does SHIFT stand for?. ### Response: chronic heart failure.


Instruction: When did the Lancet 376:875-85 publish?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Lancet 376:875-85 publish?. ### Response: 2010.


Instruction: What is stable coronary artery disease without clinical heart failure?

Output: Ivabradine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is stable coronary artery disease without clinical heart failure?. ### Response: Ivabradine.


Instruction: What is Ivabradine for patients with stable coro-nary arterial disease and left-ventricular systolic dysfunction?

Output: BEAUTIFUL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Ivabradine for patients with stable coro-nary arterial disease and left-ventricular systolic dysfunction?. ### Response: BEAUTIFUL.


Instruction: What are Pooled Cohort Equations S4.4.1.2-1?

Output: multiple cardiovascular risk scores

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are Pooled Cohort Equations S4.4.1.2-1?. ### Response: multiple cardiovascular risk scores.


Instruction: What is an analysis of calibra-tion and discrimination among multiple cardiovascular risk scores in a modern multiethnic cohort?

Output: DeFilippis AP , Young R, Carrubba CJ, et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an analysis of calibra-tion and discrimination among multiple cardiovascular risk scores in a modern multiethnic cohort?. ### Response: DeFilippis AP , Young R, Carrubba CJ, et al.


Instruction: What are the ACC/AHA guidelines, Adult Treatment Panel III guidelines, and European Society of Cardiology guidelines for?

Output: cardiovascular disease prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the ACC/AHA guidelines, Adult Treatment Panel III guidelines, and European Society of Cardiology guidelines for?. ### Response: cardiovascular disease prevention.


Instruction: What is the name of the study that compares the use and custom-ization of risk scores?

Output: Framingham Heart Study Offspring Cohort

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that compares the use and custom-ization of risk scores?. ### Response: Framingham Heart Study Offspring Cohort.


Instruction: When did JAMA issue 311:1416-23?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did JAMA issue 311:1416-23?. ### Response: 2014.


Instruction: What does Bandyopadhyay use and custom-ization of risk scores for predicting using electronic health record data?

Output: cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Bandyopadhyay use and custom-ization of risk scores for predicting using electronic health record data?. ### Response: cardiovascular events.


Instruction: What is the 2013 ACC/AHA guideline on the assessment of cardiovascular risk?

Output: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2013 ACC/AHA guideline on the assessment of cardiovascular risk?. ### Response: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.


Instruction: What did the American College of Cardiology/American Heart Association Task Force on Practice Guidelines do?

Output: assessment of cardiovascular risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the American College of Cardiology/American Heart Association Task Force on Practice Guidelines do?. ### Response: assessment of cardiovascular risk.


Instruction: What was the 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce?

Output: ath-erosclerotic cardiovascular risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce?. ### Response: ath-erosclerotic cardiovascular risk.


Instruction: Ath-erosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Ath-erosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.. ### Response: 2013.


Instruction: Circulation. 2014;129:S1–45.

Output: S4.4.1.2-6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation. 2014;129:S1–45.. ### Response: S4.4.1.2-6.


Instruction: Joint British Societies' consensus recommendations for the prevention of cardiovascular disease (JBS3) Heart 2014; 100 suppl 2. ii1–67.

Output: JBS3 Board. Joint British Societies’ consensus recommendations for the prevention of cardiovascular disease (JBS3) Heart 2014; 100 suppl 2. ii1–67. S4.4.1.2-7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Joint British Societies' consensus recommendations for the prevention of cardiovascular disease (JBS3) Heart 2014; 100 suppl 2. ii1–67.. ### Response: JBS3 Board. Joint British Societies’ consensus recommendations for the prevention of cardiovascular disease (JBS3) Heart 2014; 100 suppl 2. ii1–67. S4.4.1.2-7.


Instruction: What is the suppl 2. ii1–67?

Output: S4.4.1.2-7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the suppl 2. ii1–67?. ### Response: S4.4.1.2-7.


Instruction: What are the equations for atherosclerotic cardiovascular disease?

Output: Pooled Cohort risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the equations for atherosclerotic cardiovascular disease?. ### Response: Pooled Cohort risk.


Instruction: When did the JAMA issue 311:1406–15?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the JAMA issue 311:1406–15?. ### Response: 2014.


Instruction: What are the guidelines on eligibility for statin therapy in the commu-nity?

Output: US cholesterol guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the guidelines on eligibility for statin therapy in the commu-nity?. ### Response: US cholesterol guidelines.


Instruction: What is the comparison of observed and predicted risks in the Framingham Heart Study Offspring Cohort?

Output: Implications of the US cholesterol guidelines on eligibility for statin therapy in the commu-nity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the comparison of observed and predicted risks in the Framingham Heart Study Offspring Cohort?. ### Response: Implications of the US cholesterol guidelines on eligibility for statin therapy in the commu-nity.


Instruction: How are atherosclerotic cardiovascular disease pooled cohort risk equations by social deprivation status?

Output: Performance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are atherosclerotic cardiovascular disease pooled cohort risk equations by social deprivation status?. ### Response: Performance.


Instruction: What is the J Am Heart Assoc. 2017;6:e005676?

Output: Performance of the atherosclerotic cardiovascular disease pooled cohort risk equations by social deprivation status

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the J Am Heart Assoc. 2017;6:e005676?. ### Response: Performance of the atherosclerotic cardiovascular disease pooled cohort risk equations by social deprivation status.


Instruction: Cook NR, Ridker PM. Further insight into the cardiovascular risk calculator: the roles of statins, revascularizations and underas-certainty in the Women's Health Study.

Output: J Am Heart Assoc. 2017;6:e005676. S4.4.1.2-10. Cook NR, Ridker PM. Further insight into the cardiovascular risk calculator: the roles of statins, revascularizations, and underas-certainment in the Women’s Health Study. JAMA Intern Med. 2014;174:1964–71. S4.4.1.2-11. Dalton JE, Perzynski AT, Zidar DA, et al. Accuracy of cardiovascular risk prediction varies by neighborhood socioeconomic position

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cook NR, Ridker PM. Further insight into the cardiovascular risk calculator: the roles of statins, revascularizations and underas-certainty in the Women's Health Study.. ### Response: J Am Heart Assoc. 2017;6:e005676. S4.4.1.2-10. Cook NR, Ridker PM. Further insight into the cardiovascular risk calculator: the roles of statins, revascularizations, and underas-certainment in the Women’s Health Study. JAMA Intern Med. 2014;174:1964–71. S4.4.1.2-11. Dalton JE, Perzynski AT, Zidar DA, et al. Accuracy of cardiovascular risk prediction varies by neighborhood socioeconomic position.


Instruction: What year did JAMA Intern Med publish 174:1964–71?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did JAMA Intern Med publish 174:1964–71?. ### Response: 2014.


Instruction: What is the name of the retrospective cohort study that examined the accuracy of cardiovascular risk prediction?

Output: Pooled Cohort Equations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the retrospective cohort study that examined the accuracy of cardiovascular risk prediction?. ### Response: Pooled Cohort Equations.


Instruction: How many people were enrolled in the cohort study in 2017?

Output: 6:e005676

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were enrolled in the cohort study in 2017?. ### Response: 6:e005676.


Instruction: Who conducted a study to assess and refine myocardial infarction risk estimation among patients with human immunodeficiency virus?

Output: Centers for AIDS Research Network of Integrated Clinical Systems

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who conducted a study to assess and refine myocardial infarction risk estimation among patients with human immunodeficiency virus?. ### Response: Centers for AIDS Research Network of Integrated Clinical Systems.


Instruction: What did the Centers for AIDS Research Network of Integrated Clinical Systems do?

Output: Assessing and refin-ing myocardial infarction risk estimation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Centers for AIDS Research Network of Integrated Clinical Systems do?. ### Response: Assessing and refin-ing myocardial infarction risk estimation.


Instruction: Who is the Chair of the ACC/AHA Task Force on Clinical Practice Guidelines1?

Output: ERC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Chair of the ACC/AHA Task Force on Clinical Practice Guidelines1?. ### Response: ERC.


Instruction: What are the recommendations listed in this clinical practice guide-line whenever possible?

Output: evidence-based

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the recommendations listed in this clinical practice guide-line whenever possible?. ### Response: evidence-based.


Instruction: How is literature de-rived from research involving human subjects indexed?

Output: MEDLINE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is literature de-rived from research involving human subjects indexed?. ### Response: MEDLINE.


Instruction: What is MEDLINE indexed in?

Output: PubMed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is MEDLINE indexed in?. ### Response: PubMed.


Instruction: When was the search conducted?

Output: April 2016 to September 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the search conducted?. ### Response: April 2016 to September 2016.


Instruction: What was the key search words?

Output: sudden cardiac death, ventricular tachycardia, ventricular fibrillation, pre-mature ventricular contractions, implantable cardioverter-defibrillator, subcutaneous implantable cardioverter-defi-brillator, wearable cardioverter-defibrillator, and catheter ablation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the key search words?. ### Response: sudden cardiac death, ventricular tachycardia, ventricular fibrillation, pre-mature ventricular contractions, implantable cardioverter-defibrillator, subcutaneous implantable cardioverter-defi-brillator, wearable cardioverter-defibrillator, and catheter ablation.


Instruction: What are some of the studies that were included in the guideline writing process?

Output: ERC and the writing com-mittee members

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the studies that were included in the guideline writing process?. ### Response: ERC and the writing com-mittee members.


Instruction: What is a subcutaneous implantable cardioverter-defi-brillator?

Output: implantable cardioverter-defibrillator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a subcutaneous implantable cardioverter-defi-brillator?. ### Response: implantable cardioverter-defibrillator.


Instruction: What are the final evidence tables included in?

Output: Online Data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the final evidence tables included in?. ### Response: Online Data.


Instruction: What summarizes the evidence used by the writing committee to formulate recommendations?

Output: final evidence tables

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What summarizes the evidence used by the writing committee to formulate recommendations?. ### Response: final evidence tables.


Instruction: The writing committee reviewed documents related to what?

Output: the guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The writing committee reviewed documents related to what?. ### Response: the guideline.


Instruction: What is VA?

Output: ventricular arrhythmias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is VA?. ### Response: ventricular arrhythmias.


Instruction: What is SCD?

Output: sudden cardiac death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SCD?. ### Response: sudden cardiac death.


Instruction: Who was commissioned to perform a formal systematic review?

Output: an independent ERC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was commissioned to perform a formal systematic review?. ### Response: an independent ERC.


Instruction: Who was commissioned to perform a formal systematic review of 2 important clinical questions?

Output: an independent ERC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was commissioned to perform a formal systematic review of 2 important clinical questions?. ### Response: an independent ERC.


Instruction: What was felt to be lacking or limited?

Output: clear literature and prior guideline consensus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was felt to be lacking or limited?. ### Response: clear literature and prior guideline consensus.


Instruction: Who considered the results of the ERC review for incorporation into the guideline?

Output: the writing committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who considered the results of the ERC review for incorporation into the guideline?. ### Response: the writing committee.


Instruction: Who evaluated other published data relevant to the guideline?

Output: writing committee members

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who evaluated other published data relevant to the guideline?. ### Response: writing committee members.


Instruction: What were the findings of the ERC and the writing committee members presented and discussed?

Output: guideline recommendations were developed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the findings of the ERC and the writing committee members presented and discussed?. ### Response: guideline recommendations were developed.


Instruction: How were guideline recommendations developed?

Output: evidence-based

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How were guideline recommendations developed?. ### Response: evidence-based.


Instruction: What is published in conjunction with the 2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Ar-rhythmias and the Prevention of Sudden Cardiac Death?

Output: Systematic Review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is published in conjunction with the 2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Ar-rhythmias and the Prevention of Sudden Cardiac Death?. ### Response: Systematic Review.


Instruction: What has the ACC and AHA acknowledged the impor-tance of value in health care?

Output: S1.4-1The ACC and AHA have acknowledged the impor -tance of value in health care and have called for even-tual development of a Level of Value for clinical practice recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has the ACC and AHA acknowledged the impor-tance of value in health care?. ### Response: S1.4-1The ACC and AHA have acknowledged the impor -tance of value in health care and have called for even-tual development of a Level of Value for clinical practice recommendations.


Instruction: What do they call for even-tual development of for clinical practice recommendations?

Output: a Level of Value

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do they call for even-tual development of for clinical practice recommendations?. ### Response: a Level of Value.


Instruction: What was determined to be sufficient to support 2 specific?

Output: Available cost-effectiveness data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was determined to be sufficient to support 2 specific?. ### Response: Available cost-effectiveness data.


Instruction: What is central to the diagnosis and management of patients with IE?

Output: EchocardiographyEchocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is central to the diagnosis and management of patients with IE?. ### Response: EchocardiographyEchocardiography.


Instruction: What are major criteria in the diagnosis of IE patients?

Output: echocar -diographic evidence of an oscillating intracardiac mass or vegetation, an annular abscess, prosthetic valve partial dehis-cence, and new valvular regurgitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are major criteria in the diagnosis of IE patients?. ### Response: echocar -diographic evidence of an oscillating intracardiac mass or vegetation, an annular abscess, prosthetic valve partial dehis-cence, and new valvular regurgitation.


Instruction: What are major criteria in the diagnosis of IE?

Output: echocar -diographic evidence of an oscillating intracardiac mass or vegetation, an annular abscess, prosthetic valve partial dehis-cence, and new valvular regurgitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are major criteria in the diagnosis of IE?. ### Response: echocar -diographic evidence of an oscillating intracardiac mass or vegetation, an annular abscess, prosthetic valve partial dehis-cence, and new valvular regurgitation.


Instruction: What are done in many patients with IE dur ing initial evaluation and subsequent follow-up and provide complementary information?

Output: TTE and TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are done in many patients with IE dur ing initial evaluation and subsequent follow-up and provide complementary information?. ### Response: TTE and TEE.


Instruction: TTE should be done first in all cases of suspected what?

Output: IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: TTE should be done first in all cases of suspected what?. ### Response: IE.


Instruction: What should be performed as soon as pos-sible after TTE?

Output: TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be performed as soon as pos-sible after TTE?. ### Response: TEE.


Instruction: What are some circum-stances that preclude optimal echocardiographic windows?

Output: chronic obstructive lung disease, previous thoracic or cardiovascular surgery, morbid obesity, or other conditions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some circum-stances that preclude optimal echocardiographic windows?. ### Response: chronic obstructive lung disease, previous thoracic or cardiovascular surgery, morbid obesity, or other conditions.


Instruction: When is TTE negative and clinical suspicion remains low, what should be considered?

Output: other clinical entities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is TTE negative and clinical suspicion remains low, what should be considered?. ### Response: other clinical entities.


Instruction: What is unlikely to alter initial medi-cal management?

Output: TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is unlikely to alter initial medi-cal management?. ### Response: TEE.


Instruction: What should be performed first if clinical suspicion of IE or its complications is high?

Output: TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be performed first if clinical suspicion of IE or its complications is high?. ### Response: TEE.


Instruction: In adults, what has shown TEE to be significantly more?

Output: Investigation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In adults, what has shown TEE to be significantly more?. ### Response: Investigation.


Instruction: What is TEE more sensitive to?

Output: detection of veg-etations and abscesses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is TEE more sensitive to?. ### Response: detection of veg-etations and abscesses.


Instruction: What is hampered by the structural components of the prosthesis in setting a prosthesis?

Output: transthoracic images

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hampered by the structural components of the prosthesis in setting a prosthesis?. ### Response: transthoracic images.


Instruction: Where do infections often start?

Output: perivalvular area

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where do infections often start?. ### Response: perivalvular area.


Instruction: What should be the first examination in adults with suspected IE?

Output: TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be the first examination in adults with suspected IE?. ### Response: TEE.


Instruction: Why are many patients not candidates for immediate TEE?

Output: because of having eaten within the preceding 6 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why are many patients not candidates for immediate TEE?. ### Response: because of having eaten within the preceding 6 hours.


Instruction: Why are patients not candidates for immediate TEE?

Output: because of having eaten within the preceding 6 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why are patients not candidates for immediate TEE?. ### Response: because of having eaten within the preceding 6 hours.


Instruction: What should be performed without delay when TEE is not clinically possible or must be delayed?

Output: early TTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be performed without delay when TEE is not clinically possible or must be delayed?. ### Response: early TTE.


Instruction: What should be performed without delay?

Output: early TTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be performed without delay?. ### Response: early TTE.


Instruction: TTE will not definitively exclude what?

Output: vegeta-tions or abscesses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: TTE will not definitively exclude what?. ### Response: vegeta-tions or abscesses.


Instruction: It will allow identification of what patients?

Output: very-high-risk patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: It will allow identification of what patients?. ### Response: very-high-risk patients.


Instruction: What is needed to better define the subgroup of patients with bloodstream infection caused by S aureus who need only TTE to evaluate for IE?

Output: further work

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed to better define the subgroup of patients with bloodstream infection caused by S aureus who need only TTE to evaluate for IE?. ### Response: further work.


Instruction: What are the recommendations for Electrocardiographic Monitoring?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the recommendations for Electrocardiographic Monitoring?. ### Response: ...............


Instruction: What is the recommendation for Pulmonary Artery Catheterization?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommendation for Pulmonary Artery Catheterization?. ### Response: ...............


Instruction: What type of Imaging is used to reduce Stroke Rates?

Output: Epiaortic Ultra-sound

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of Imaging is used to reduce Stroke Rates?. ### Response: Epiaortic Ultra-sound.


Instruction: What is the role of PreoperativeCarotid Artery Noninva-sive Screening in CABGPatients: Recommendations?

Output: Recommenda-tions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of PreoperativeCarotid Artery Noninva-sive Screening in CABGPatients: Recommendations?. ### Response: Recommenda-tions.


Instruction: What is the term for CognitiveImpairment?

Output: Postoperative

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for CognitiveImpairment?. ### Response: Postoperative.


Instruction: What is another term for Mediastinitis/Perioperative Infection?

Output: Recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for Mediastinitis/Perioperative Infection?. ### Response: Recommendations.


Instruction: How is Renal Dysfunction described?

Output: Recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is Renal Dysfunction described?. ### Response: Recommendations.


Instruction: What type of disease does Diabetes Mellitus have?

Output: Chronic Obstructive PulmonaryDisease/Respiratory Insufficiency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of disease does Diabetes Mellitus have?. ### Response: Chronic Obstructive PulmonaryDisease/Respiratory Insufficiency.


Instruction: What is the name of the disease that causes End-Stage Renal Disease onDialysis?

Output: Chronic Obstructive PulmonaryDisease/Respiratory Insufficiency:Recommendations ..................... .e6966.6. Patients With End-Stage Renal Disease onDialysis: Recommendations .............. .e6976.7. Patients With Concomitant Valvular Disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease that causes End-Stage Renal Disease onDialysis?. ### Response: Chronic Obstructive PulmonaryDisease/Respiratory Insufficiency:Recommendations ..................... .e6966.6. Patients With End-Stage Renal Disease onDialysis: Recommendations .............. .e6976.7. Patients With Concomitant Valvular Disease.


Instruction: How many patients have had previous Cardiac surgery?

Output: e6976.8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients have had previous Cardiac surgery?. ### Response: e6976.8.


Instruction: What are the Indications for Repeat CABG?

Output: Operative Risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Indications for Repeat CABG?. ### Response: Operative Risk.