Instruction: How long did it take for patients with a recent small vessel, lacunar stroke to enroll in the study?

Output: >40 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for patients with a recent small vessel, lacunar stroke to enroll in the study?. ### Response: >40 days.


Instruction: How long was the qualifying event to enrollment in the SPS3 trial?

Output: >40 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the qualifying event to enrollment in the SPS3 trial?. ### Response: >40 days.


Instruction: What may have underestimated benefit in the early poststroke period?

Output: the median time from the qualifying event to enrollment in the SPS3 trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may have underestimated benefit in the early poststroke period?. ### Response: the median time from the qualifying event to enrollment in the SPS3 trial.


Instruction: How many studies did a recent meta-analysis of 5 studies include?

Output: 3 RCTs and 2 observational registries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies did a recent meta-analysis of 5 studies include?. ### Response: 3 RCTs and 2 observational registries.


Instruction: What was found to decrease the risk of major cardiovascular events and recurrent stroke in patients switching to an alternative antiplatelet agent?

Output: aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was found to decrease the risk of major cardiovascular events and recurrent stroke in patients switching to an alternative antiplatelet agent?. ### Response: aspirin.


Instruction: What was included in the analysis of data from aspirin failure subgroups?

Output: CHANCE trial of dual antiplatelet therapy in patients with minor stroke or TIA and the SOCRATES trial of aspirin versus ticagrelor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was included in the analysis of data from aspirin failure subgroups?. ### Response: CHANCE trial of dual antiplatelet therapy in patients with minor stroke or TIA and the SOCRATES trial of aspirin versus ticagrelor.


Instruction: What were the subgroups in the CHANCE trial of?

Output: aspirin failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the subgroups in the CHANCE trial of?. ### Response: aspirin failure.


Instruction: What was the SOCRATES trial of aspirin versus?

Output: ticagrelor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the SOCRATES trial of aspirin versus?. ### Response: ticagrelor.


Instruction: Data from registries are susceptible to unmeasured confounders and what else?

Output: bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Data from registries are susceptible to unmeasured confounders and what else?. ### Response: bias.


Instruction: What is e vidence t hat rapidly lo wering blood pr essur e does not incr ease the risk of neurological det erioration caused by reduced blood flo w to the brain and has potential to impr ove quality of lif e?

Output: has t he pot ential to impr ove quality of lif e

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is e vidence t hat rapidly lo wering blood pr essur e does not incr ease the risk of neurological det erioration caused by reduced blood flo w to the brain and has potential to impr ove quality of lif e?. ### Response: has t he pot ential to impr ove quality of lif e.


Instruction: ential to impr ove quality of lif e?

Output: extrapolat e from t he available data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ential to impr ove quality of lif e?. ### Response: extrapolat e from t he available data.


Instruction: In anot her clinical trial, t here was no benefit t o rapidly lo wering what?

Output: blood pr essur e

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In anot her clinical trial, t here was no benefit t o rapidly lo wering what?. ### Response: blood pr essur e.


Instruction: What was an incr ease in adv erse r enal vents?

Output: rapid blood pr essur e lowering tr eatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was an incr ease in adv erse r enal vents?. ### Response: rapid blood pr essur e lowering tr eatment.


Instruction: What is an incr ease in adv erse r enal e vents?

Output: rapid blood pr essur e lowering tr eatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an incr ease in adv erse r enal e vents?. ### Response: rapid blood pr essur e lowering tr eatment.


Instruction: The committ ee not ed what in t he trial?

Output: the tr eatment r egimens

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committ ee not ed what in t he trial?. ### Response: the tr eatment r egimens.


Instruction: What did the committee agr eed t hat rapid blood pr essur e lowering tr eatment is beneficial?

Output: an incr ease in adv erse r enal e vents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee agr eed t hat rapid blood pr essur e lowering tr eatment is beneficial?. ### Response: an incr ease in adv erse r enal e vents.


Instruction: What was an incr ease in?

Output: adv erse r enal e vents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was an incr ease in?. ### Response: adv erse r enal e vents.


Instruction: Who was concerned about the lack of evidence in people who ar e frail?

Output: committ ee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was concerned about the lack of evidence in people who ar e frail?. ### Response: committ ee.


Instruction: What should be considered ed?

Output: rapid blood pr essur e lowering tr eatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered ed?. ### Response: rapid blood pr essur e lowering tr eatment.


Instruction: What should be considered as a tr eatment option xcept f or the gr oups highlight ed in recommendation 1.5.7?

Output: rapid blood pr essur e lowering tr eatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered as a tr eatment option xcept f or the gr oups highlight ed in recommendation 1.5.7?. ### Response: rapid blood pr essur e lowering tr eatment.


Instruction: Ther e was evidence t hat a moderat e reduction of up to what?

Output: 60  mmHg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Ther e was evidence t hat a moderat e reduction of up to what?. ### Response: 60  mmHg.


Instruction: What was associat ed wit h better out comes such as functional independence?

Output: ot her trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associat ed wit h better out comes such as functional independence?. ### Response: ot her trials.


Instruction: A r eduction of mor e than 60 mmHg wit hin 1 hour was what?

Output: associat ed wit h significant ly worse out comes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A r eduction of mor e than 60 mmHg wit hin 1 hour was what?. ### Response: associat ed wit h significant ly worse out comes.


Instruction: What is an example of a significantly worse out come?

Output: renal f ailure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a significantly worse out come?. ### Response: renal f ailure.


Instruction: What is a compar ed wit h standar d treatment?

Output: her trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a compar ed wit h standar d treatment?. ### Response: her trials.


Instruction: Ther efore, the committ ee agreed t hat a lar ge reduction of what?

Output: 60  mmHg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Ther efore, the committ ee agreed t hat a lar ge reduction of what?. ### Response: 60  mmHg.


Instruction: What should a reduction of 60 mmHg or mor e within 1 hour be a voided?

Output: lar ge

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should a reduction of 60 mmHg or mor e within 1 hour be a voided?. ### Response: lar ge.


Instruction: The 2019 guideline included a what?

Output: 130 mmHg lo wer tar get limit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The 2019 guideline included a what?. ### Response: 130 mmHg lo wer tar get limit.


Instruction: What is t he variation in class of drugs used in practice?

Output: it is difficult t o predict t he blood pr essur e reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is t he variation in class of drugs used in practice?. ### Response: it is difficult t o predict t he blood pr essur e reduction.


Instruction: What is difficult to predict?

Output: blood pr essur e reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is difficult to predict?. ### Response: blood pr essur e reduction.


Instruction: The committee decided to remove what?

Output: 130 mmHg lo wer tar get limit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committee decided to remove what?. ### Response: 130 mmHg lo wer tar get limit.


Instruction: Who decided to remove the 130 mmHg lo wer tar get limit?

Output: The committ ee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who decided to remove the 130 mmHg lo wer tar get limit?. ### Response: The committ ee.


Instruction: The committee considered the pot ential risk of syst olic blood pr essur e dropping what?

Output: t oo lo w

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committee considered the pot ential risk of syst olic blood pr essur e dropping what?. ### Response: t oo lo w.


Instruction: What is addedressed b y the avoidance of a lar ge reduction of 60 mmHg or mor e wit hin 1 hour?

Output: syst olic blood pr essur e dropping t oo lo w but not ed that t his pot ential concern

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is addedressed b y the avoidance of a lar ge reduction of 60 mmHg or mor e wit hin 1 hour?. ### Response: syst olic blood pr essur e dropping t oo lo w but not ed that t his pot ential concern.


Instruction: The committee also agr eed t hat the tar get syst olic blood pr essur e and what else?

Output: reduction should be made int o a separat e recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committee also agr eed t hat the tar get syst olic blood pr essur e and what else?. ### Response: reduction should be made int o a separat e recommendation.


Instruction: What should be made int o a separat e recommendation?

Output: syst olic blood pr essur e reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be made int o a separat e recommendation?. ### Response: syst olic blood pr essur e reduction.


Instruction: What was litt le evidence on people pr esenting be yond 6 hours?

Output: Ther e

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was litt le evidence on people pr esenting be yond 6 hours?. ### Response: Ther e.


Instruction: How many mmHg of blood does a person with a syst olic blood pr essur e?

Output: 220

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mmHg of blood does a person with a syst olic blood pr essur e?. ### Response: 220.


Instruction: What is agr eed t hat some guidance is needed on tr eating h yper tension?

Output: the committ ee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is agr eed t hat some guidance is needed on tr eating h yper tension?. ### Response: the committ ee.


Instruction: What should healt hcare professionals take into account when considering rapid blood pr essur e lowering?

Output: risk of harm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should healt hcare professionals take into account when considering rapid blood pr essur e lowering?. ### Response: risk of harm.


Instruction: What type of blood pr essur e lowering is used on a case-by-case basis?

Output: rapid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of blood pr essur e lowering is used on a case-by-case basis?. ### Response: rapid.


Instruction: Stroke and transient ischaemic attack in what age group?

Output: 16s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Stroke and transient ischaemic attack in what age group?. ### Response: 16s.


Instruction: How many drinks a day should nonpregnant women have?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many drinks a day should nonpregnant women have?. ### Response: 1.


Instruction: How many ounces of beer or spirits should men have if they have SIHD?

Output: 12

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many ounces of beer or spirits should men have if they have SIHD?. ### Response: 12.


Instruction: What type of alcohol is contraindicated in patients with SIHD who use alcohol?

Output: Light to moderate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of alcohol is contraindicated in patients with SIHD who use alcohol?. ### Response: Light to moderate.


Instruction: What is the level of evidence for alcohol consumption?

Output: Light to moderate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the level of evidence for alcohol consumption?. ### Response: Light to moderate.


Instruction: What is associated with a lower risk of IHD andall-cause mortality?

Output: light to moderate alcoholconsumption

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with a lower risk of IHD andall-cause mortality?. ### Response: light to moderate alcoholconsumption.


Instruction: Most studies report a J-shaped relation between alcohol consumed and what?

Output: cardiovascular event rateor mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Most studies report a J-shaped relation between alcohol consumed and what?. ### Response: cardiovascular event rateor mortality.


Instruction: Most studies report a J-shaped relation between alcohol consumed and cardiovascular event rateor mortality.

Output: Class IIb1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Most studies report a J-shaped relation between alcohol consumed and cardiovascular event rateor mortality.. ### Response: Class IIb1.


Instruction: Light to moderate drinkers have less risk than what?

Output: abstainers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Light to moderate drinkers have less risk than what?. ### Response: abstainers.


Instruction: Heavy drinkers are at what risk?

Output: greatest risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Heavy drinkers are at what risk?. ### Response: greatest risk.


Instruction: A meta-analysis of 34 prospective studies found mortality rate reduc-tions of 17% in men and 18% in women with low alcohol consumption?

Output: 703

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A meta-analysis of 34 prospective studies found mortality rate reduc-tions of 17% in men and 18% in women with low alcohol consumption?. ### Response: 703.


Instruction: What percentage of men have low levels of alcohol intake?

Output: 17%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of men have low levels of alcohol intake?. ### Response: 17%.


Instruction: What is the lowest mortality rate at 6g of alcohol per day?

Output: approximately one half drink)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the lowest mortality rate at 6g of alcohol per day?. ### Response: approximately one half drink).


Instruction: Inpatients with IHD are what?

Output: limited

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Inpatients with IHD are what?. ### Response: limited.


Instruction: What was the survival rate among early survivors of MI?

Output: 30%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the survival rate among early survivors of MI?. ### Response: 30%.


Instruction: What was predictive of lower all-cause mortality?

Output: light to moderate alcoholconsumption

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was predictive of lower all-cause mortality?. ### Response: light to moderate alcoholconsumption.


Instruction: How much lower was the risk of death among moderate drinkers than abstainers?

Output: 30%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much lower was the risk of death among moderate drinkers than abstainers?. ### Response: 30%.


Instruction: What is a 30% lower risk of death than abstainers?

Output: moderate drinkers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a 30% lower risk of death than abstainers?. ### Response: moderate drinkers.


Instruction: Light to moderate alcohol consumption might confer pro-tection against what?

Output: cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Light to moderate alcohol consumption might confer pro-tection against what?. ### Response: cardiovascular disease.


Instruction: Alcohol intake modestly increases HDL cholesterol in a dose-dependent fashion.

Output: 706,707

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Alcohol intake modestly increases HDL cholesterol in a dose-dependent fashion.. ### Response: 706,707.


Instruction: Consumption of how many drinks per daylowers fasting and postprandial insulin levels?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Consumption of how many drinks per daylowers fasting and postprandial insulin levels?. ### Response: 2.


Instruction: How often have you been bothered by any of the problems mentioned above?

Output: Little interest or pleasure in doing things

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often have you been bothered by any of the problems mentioned above?. ### Response: Little interest or pleasure in doing things.


Instruction: What do drinks lower in healthy subjects?

Output: fasting and postprandial insulin levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do drinks lower in healthy subjects?. ### Response: fasting and postprandial insulin levels.


Instruction: How often do you feel down?

Output: depressed, or hopeless

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often do you feel down?. ### Response: depressed, or hopeless.


Instruction: How often have you been bothered by any of the following problems?

Output: Over the past 2 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often have you been bothered by any of the following problems?. ### Response: Over the past 2 weeks.


Instruction: What is the name of the patient health questionaire?

Output: 9: DepressionScreening Scales

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the patient health questionaire?. ### Response: 9: DepressionScreening Scales.


Instruction: What do you feel about yourself?

Output: Feeling bad

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do you feel about yourself?. ### Response: Feeling bad.


Instruction: What does it feel like to be down, depressed or hopeless?

Output: Little interest or pleasure in doing things

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does it feel like to be down, depressed or hopeless?. ### Response: Little interest or pleasure in doing things.


Instruction: How do you feel about yourself or your family?

Output: you have let yourself or your family down

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do you feel about yourself or your family?. ### Response: you have let yourself or your family down.


Instruction: What do you do when you feel like you have let yourself down?

Output: Little interest or pleasure in doing things

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do you do when you feel like you have let yourself down?. ### Response: Little interest or pleasure in doing things.


Instruction: How are you feeling about yourself?

Output: down, depressed, or hopeless

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are you feeling about yourself?. ### Response: down, depressed, or hopeless.


Instruction: What do you think you would be better off doing if you were dead?

Output: you want to hurtyourself

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do you think you would be better off doing if you were dead?. ### Response: you want to hurtyourself.


Instruction: How do you feel about yourself?

Output: Feeling bad

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do you feel about yourself?. ### Response: Feeling bad.


Instruction: What do pr ofessionals and practitioners expect to tak when e xercising t heir judgement?

Output: this guideline fully int o account

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do pr ofessionals and practitioners expect to tak when e xercising t heir judgement?. ### Response: this guideline fully int o account.


Instruction: What are the r ecommendations in NICE?

Output: epresent t he view of NICE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the r ecommendations in NICE?. ### Response: epresent t he view of NICE.


Instruction: What are practitioners expected to tak e this guideline fully int o account?

Output: assess and r educe t he en vironmental impact

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are practitioners expected to tak e this guideline fully int o account?. ### Response: assess and r educe t he en vironmental impact.


Instruction: What is not mandatory to apply t he recommendations?

Output: It is not mandat ory

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not mandatory to apply t he recommendations?. ### Response: It is not mandat ory.


Instruction: What does not verride t he responsibility to make decisions appr opriat e to the cir cumstances of a person?

Output: t he guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not verride t he responsibility to make decisions appr opriat e to the cir cumstances of a person?. ### Response: t he guideline.


Instruction: What should all pr oblems related to a medicine or medical de vice be r eported to?

Output: Medicines and Healt hcare product s Regulat ory Agency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should all pr oblems related to a medicine or medical de vice be r eported to?. ### Response: Medicines and Healt hcare product s Regulat ory Agency.


Instruction: What does the Medicines and Healt hcare product s Regulat ory Agency use?

Output: Yellow Car

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Medicines and Healt hcare product s Regulat ory Agency use?. ### Response: Yellow Car.


Instruction: Who has a responsibility to enable t he guideline to be applied when individual pr ofessionals and people using sertaint h care use a guideline?

Output: Local commissioners and pr oviders of healt hcare

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who has a responsibility to enable t he guideline to be applied when individual pr ofessionals and people using sertaint h care use a guideline?. ### Response: Local commissioners and pr oviders of healt hcare.


Instruction: What should be applied when individual pr ofessionals and people using ser vices wish to use it?

Output: guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be applied when individual pr ofessionals and people using ser vices wish to use it?. ### Response: guideline.


Instruction: What should the y do in t he cont ext of local and national priorities?

Output: funding and developing ser vices

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should the y do in t he cont ext of local and national priorities?. ### Response: funding and developing ser vices.


Instruction: What should not be int erpreted in a wa y?

Output: guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not be int erpreted in a wa y?. ### Response: guideline.


Instruction: What should be eliminated in light of t heir duties?

Output: unlawful discrimination

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be eliminated in light of t heir duties?. ### Response: unlawful discrimination.


Instruction: Who has a responsibility to promote an environmentally sustainable healt h and car e syst em?

Output: Commissioners and pr oviders

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who has a responsibility to promote an environmentally sustainable healt h and car e syst em?. ### Response: Commissioners and pr oviders.


Instruction: What should be int erpreted in a wa y that would be inconsist ent wit h his duties?

Output: Not hing in t his guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be int erpreted in a wa y that would be inconsist ent wit h his duties?. ### Response: Not hing in t his guideline.


Instruction: What should assess and r educe the environmental impact of implementing NICE recommendations wher ever possible?

Output: Commissioners and pr oviders

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should assess and r educe the environmental impact of implementing NICE recommendations wher ever possible?. ### Response: Commissioners and pr oviders.


Instruction: Cardiovascular disease: risk assessment and reduction, including lipid modification(CG181)?

Output: NICE 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cardiovascular disease: risk assessment and reduction, including lipid modification(CG181)?. ### Response: NICE 2023.


Instruction: What is the subject t o Notice of right s?

Output: All right s reserved

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the subject t o Notice of right s?. ### Response: All right s reserved.


Instruction: Where is the last updat ed?

Output: 10 F ebruar y 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the last updat ed?. ### Response: 10 F ebruar y 2023.


Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020 Page 118 of 127 References?

Output: Evidence based practice work group charter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020 Page 118 of 127 References?. ### Response: Evidence based practice work group charter.


Instruction: Who is the U.S. Department of Veterans Affairs/Department of Defense?

Output: Health Executive Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the U.S. Department of Veterans Affairs/Department of Defense?. ### Response: Health Executive Committee.


Instruction: What did the Centers for Disease Control and Prevention publish on January 9, 2017?

Output: Total and high -density lipoprotein cholesterol in adults: United States, 2015 –2016. 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Centers for Disease Control and Prevention publish on January 9, 2017?. ### Response: Total and high -density lipoprotein cholesterol in adults: United States, 2015 –2016. 2017.


Instruction: What is the name of the document that was updated on January 9th, 2017 at healthquality.va.gov?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the document that was updated on January 9th, 2017 at healthquality.va.gov?. ### Response: EvidenceBasedPracticeWGCharter123020161.pdf.


Instruction: When was the document updated?

Output: January  9, 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the document updated?. ### Response: January  9, 2017.


Instruction: What year did the American Heart Association publish a report on heart disease and stroke statistics?

Output: 2020

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did the American Heart Association publish a report on heart disease and stroke statistics?. ### Response: 2020.


Instruction: What is the PMID for this report?

Output: 17147811

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the PMID for this report?. ### Response: 17147811.


Instruction: Where is the U.S. Department of Veterans Affairs?

Output: Department of Defense

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the U.S. Department of Veterans Affairs?. ### Response: Department of Defense.


Instruction: What is the name of the subgroup that reviews VA guidelines?

Output: Evidence Review Subgroup

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the subgroup that reviews VA guidelines?. ### Response: Evidence Review Subgroup.


Instruction: When was the evidence review subgroup revised?

Output: January 29, 20 19

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the evidence review subgroup revised?. ### Response: January 29, 20 19.


Instruction: What is one of the GRADE guidelines that is reviewed by the VA?

Output: 15

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the GRADE guidelines that is reviewed by the VA?. ### Response: 15.


Instruction: What is a recommendation's direction and strength?

Output: Going from evidence to recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a recommendation's direction and strength?. ### Response: Going from evidence to recommendation.


Instruction: When did J Clin Epidemiol issue 66(7):726-735?

Output: Jul 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J Clin Epidemiol issue 66(7):726-735?. ### Response: Jul 2013.


Instruction: Where is the Agency for Healthcare Research located?

Output: Rockville (MD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the Agency for Healthcare Research located?. ### Response: Rockville (MD.


Instruction: Where is the Agency for Healthcare Research and Quality located?

Output: Rockville (MD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the Agency for Healthcare Research and Quality located?. ### Response: Rockville (MD.


Instruction: What is the name of the organization that reviews implementation and early experience?

Output: Agency for Healthcare Research and Quality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that reviews implementation and early experience?. ### Response: Agency for Healthcare Research and Quality.


Instruction: When was the agency for healthcare research and quality based in Rockville?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the agency for healthcare research and quality based in Rockville?. ### Response: 2008.


Instruction: What is evidence based recommendation development?

Output: work group charter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is evidence based recommendation development?. ### Response: work group charter.


Instruction: What is the PMID for Evidence Based Recommendation Development?

Output: 17147811

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the PMID for Evidence Based Recommendation Development?. ### Response: 17147811.


Instruction: When was the National Institute of Health and Care Excellence's The guidelines manual released?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the National Institute of Health and Care Excellence's The guidelines manual released?. ### Response: 2012.


Instruction: What is the current status of NICE clinical guidelines?

Output: 15

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the current status of NICE clinical guidelines?. ### Response: 15.


Instruction: What are the latest recommendations?

Output: An assessment of NICE clinical guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the latest recommendations?. ### Response: An assessment of NICE clinical guidelines.


Instruction: How does AHRQ work?

Output: using existing systematic reviews to replace de novo processes in conducting comparative effectiveness reviews

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does AHRQ work?. ### Response: using existing systematic reviews to replace de novo processes in conducting comparative effectiveness reviews.


Instruction: How are systematic reviews used to replace de novo processes in conducting comparative effectiveness reviews?

Output: AHRQ method s for effective health care using existing systematic reviews

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are systematic reviews used to replace de novo processes in conducting comparative effectiveness reviews?. ### Response: AHRQ method s for effective health care using existing systematic reviews.


Instruction: What does the Institute of Medicine Committe on Standards for Developing?

Output: Trustworthy Clinical Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Institute of Medicine Committe on Standards for Developing?. ### Response: Trustworthy Clinical Practice Guidelines.


Instruction: Who edited the Institute of Medicine Committe on Standards for Developing Trustworthy Clinical Practice Guidelines?

Output: Graham R, Mancher M, Miller Wolman D, et al.,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who edited the Institute of Medicine Committe on Standards for Developing Trustworthy Clinical Practice Guidelines?. ### Response: Graham R, Mancher M, Miller Wolman D, et al.,.


Instruction: Where did Graham R, Mancher M, Miller Wolman D, et al. publish the Clinical practice guidelines we can trust?

Output: Institute of Medicine (US) Committe on Standards for Developing Trustworthy Clinical Practice Guidelines, Graham R, Mancher M, Miller Wolman D, et al., editors. Clinical practice guidelines we can trust. Washington, DC: Nation al Academies Press

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where did Graham R, Mancher M, Miller Wolman D, et al. publish the Clinical practice guidelines we can trust?. ### Response: Institute of Medicine (US) Committe on Standards for Developing Trustworthy Clinical Practice Guidelines, Graham R, Mancher M, Miller Wolman D, et al., editors. Clinical practice guidelines we can trust. Washington, DC: Nation al Academies Press.


Instruction: What does Fretheim A, Oxman AD say is the key to guideline development?

Output: research evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Fretheim A, Oxman AD say is the key to guideline development?. ### Response: research evidence.


Instruction: What does the Health Res Policy Syt. 2006:4:22 do?

Output: Integrating values and consumer involvement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Health Res Policy Syt. 2006:4:22 do?. ### Response: Integrating values and consumer involvement.


Instruction: What year did e378 Stroke occur?

Output: 20193

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did e378 Stroke occur?. ### Response: 20193.


Instruction: What year was the AIS Guidelines revised?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the AIS Guidelines revised?. ### Response: 2013.


Instruction: What was the COR unchanged from?

Output: 2013 AIS Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the COR unchanged from?. ### Response: 2013 AIS Guidelines.


Instruction: What was LOE amended to conform with?

Output: ACC/AHA 2015 Recommendation Classification System

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was LOE amended to conform with?. ### Response: ACC/AHA 2015 Recommendation Classification System.


Instruction: The safety and usefulness of short-term anticoagulation in the setting of AIS are not well established what?

Output: nonocclusive, extracranial intraluminal thrombus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The safety and usefulness of short-term anticoagulation in the setting of AIS are not well established what?. ### Response: nonocclusive, extracranial intraluminal thrombus.


Instruction: What is the optimal medical management of patients with AIS and radiologic evidence of nonocclusive, intraluminal thrombus?

Output: remains uncertain

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the optimal medical management of patients with AIS and radiologic evidence of nonocclusive, intraluminal thrombus?. ### Response: remains uncertain.


Instruction: What has been suggested the safety of short-term IV heparin or LMWH?

Output: small observational studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been suggested the safety of short-term IV heparin or LMWH?. ### Response: small observational studies.


Instruction: What is required to establish safety and efficacy?

Output: further research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is required to establish safety and efficacy?. ### Response: further research.


Instruction: What is the usefulness of argatroban, dabigatran, or other thrombin inhibitors for the treatment of patients with AIS not well established?

Output: The safety and usefulness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the usefulness of argatroban, dabigatran, or other thrombin inhibitors for the treatment of patients with AIS not well established?. ### Response: The safety and usefulness.


Instruction: What was revised from 2013 AIS Guidelines?

Output: IIb B-RRecommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was revised from 2013 AIS Guidelines?. ### Response: IIb B-RRecommendation.


Instruction: What has shown the safety and feasibility of treating AIS with thrombin inhibitors as a single or adjunct therapy to alteplase?

Output: Several observational studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has shown the safety and feasibility of treating AIS with thrombin inhibitors as a single or adjunct therapy to alteplase?. ### Response: Several observational studies.


Instruction: How many patients with TIA or minor stroke were studied with the oral direct thrombi inhibitor dabigatran?

Output: 53

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with TIA or minor stroke were studied with the oral direct thrombi inhibitor dabigatran?. ### Response: 53.


Instruction: What is the NIHSS score for TIA or minor stroke?

Output: ≤ 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the NIHSS score for TIA or minor stroke?. ### Response: ≤ 3.


Instruction: How long did there be no occurrences of sICH up to 30 days?

Output: 224

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did there be no occurrences of sICH up to 30 days?. ### Response: 224.


Instruction: What is ARTSS?

Output: Argatroban With Recombinant Tissue Plasminogen Activator for Acute Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ARTSS?. ### Response: Argatroban With Recombinant Tissue Plasminogen Activator for Acute Stroke.


Instruction: In what study was argatroban infusion plus IV alteplase used?

Output: ARTSS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what study was argatroban infusion plus IV alteplase used?. ### Response: ARTSS.


Instruction: How many patients were diagnosed with thrombus by Doppler?

Output: 65

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were diagnosed with thrombus by Doppler?. ### Response: 65.


Instruction: How many were randomized to receive placebo or argatroban in the ARTSS-2 phase II study?

Output: patients with AIS treated with alteplase (N=90)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many were randomized to receive placebo or argatroban in the ARTSS-2 phase II study?. ### Response: patients with AIS treated with alteplase (N=90).


Instruction: What did the patients with AIS treated with alteplase receive?

Output: placebo or argatroban (100-µ g/kg bolus),

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the patients with AIS treated with alteplase receive?. ### Response: placebo or argatroban (100-µ g/kg bolus),.


Instruction: How many doses of sICH were similar among the control, low-dose, and high-dose arms?

Output: 3 of 29

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many doses of sICH were similar among the control, low-dose, and high-dose arms?. ### Response: 3 of 29.


Instruction: How long did it take to get 1 (low dose) or 3 (high dose) g/kg per minute for 48 hours?

Output: 3 of 29

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take to get 1 (low dose) or 3 (high dose) g/kg per minute for 48 hours?. ### Response: 3 of 29.


Instruction: What is needed to clarify the safety and efficacy of this intervention?

Output: Further trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed to clarify the safety and efficacy of this intervention?. ### Response: Further trials.


Instruction: What are Tables XLIX and L in online Data Supplement 1.4?

Output: 226 Further trials are necessary to clarify the safety and efficacy of this intervention.See Tables XLIX and L in online Data Supplement 1.4.  The safety and usefulness of oral factor Xa inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are Tables XLIX and L in online Data Supplement 1.4?. ### Response: 226 Further trials are necessary to clarify the safety and efficacy of this intervention.See Tables XLIX and L in online Data Supplement 1.4.  The safety and usefulness of oral factor Xa inhibitors.


Instruction: The safety and usefulness of oral factor Xa inhibitors in the treatment of AIS are not well established.

Output: IIb C-LDNew recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The safety and usefulness of oral factor Xa inhibitors in the treatment of AIS are not well established.. ### Response: IIb C-LDNew recommendation.


Instruction: What is rivaroxaban, apixaban and edoxaban used for?

Output: treatment of patients with AIS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is rivaroxaban, apixaban and edoxaban used for?. ### Response: treatment of patients with AIS.


Instruction: What is the name of a factor Xa inhibitor used for treatment of patients with AIS?

Output: rivaroxaban, apixaban, edoxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of a factor Xa inhibitor used for treatment of patients with AIS?. ### Response: rivaroxaban, apixaban, edoxaban.


Instruction: What was the target MAP of MDRD and AASKstudies instead of anSBP and a DBP target?

Output: <92 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the target MAP of MDRD and AASKstudies instead of anSBP and a DBP target?. ### Response: <92 mm Hg.


Instruction: What is often considered equivalent to 125/75 mm Hg?

Output: intensive BP arm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is often considered equivalent to 125/75 mm Hg?. ### Response: intensive BP arm.


Instruction: What is also considered equal to 116/80, 135/70, 140/68, 145/65 or other figures depending on pulse pressure?

Output: intensive BP arm, which isoften considered equivalent to 125/75 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is also considered equal to 116/80, 135/70, 140/68, 145/65 or other figures depending on pulse pressure?. ### Response: intensive BP arm, which isoften considered equivalent to 125/75 mm Hg.


Instruction: What should be the DBP of youngpatients with CKD and diastolic hypertension?

Output: <80mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be the DBP of youngpatients with CKD and diastolic hypertension?. ### Response: <80mm Hg.


Instruction: What should the SBP target be?

Output: <120 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should the SBP target be?. ### Response: <120 mm Hg.


Instruction: Why is the Work Group hesitant to recommend a DBP target?

Output: lack of evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is the Work Group hesitant to recommend a DBP target?. ### Response: lack of evidence.


Instruction: What was the 2017 ACC/AHA guideline for CKD?

Output: <130/<80 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 2017 ACC/AHA guideline for CKD?. ### Response: <130/<80 mm Hg.


Instruction: What is the SBP target of 130 mm Hg more aggressive than?

Output: EuropeanSociety of Cardiology (ESC)/European Society of Hyperten-sion (ESH)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the SBP target of 130 mm Hg more aggressive than?. ### Response: EuropeanSociety of Cardiology (ESC)/European Society of Hyperten-sion (ESH).


Instruction: 130 mm Hgis still more aggressive than what?

Output: those proposed by the EuropeanSociety of Cardiology (ESC)/European Society of Hyperten-sion (ESH)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: 130 mm Hgis still more aggressive than what?. ### Response: those proposed by the EuropeanSociety of Cardiology (ESC)/European Society of Hyperten-sion (ESH).


Instruction: What is the target?

Output: <120 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the target?. ### Response: <120 mm Hg.


Instruction: NICE proposes a target of 120-139 mmHg?

Output: 120–139 mm Hg).2,8,157,158

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: NICE proposes a target of 120-139 mmHg?. ### Response: 120–139 mm Hg).2,8,157,158.


Instruction: What does the KDIGO Work Group believe patients should not be penalized for?

Output: suboptimal clinical practice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the KDIGO Work Group believe patients should not be penalized for?. ### Response: suboptimal clinical practice.


Instruction: What should one not rely on routineoffice BP to adjust?

Output: BP-lowering therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should one not rely on routineoffice BP to adjust?. ### Response: BP-lowering therapy.


Instruction: Hypertension Canada recommends an SBP target of what?

Output: <120 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hypertension Canada recommends an SBP target of what?. ### Response: <120 mm Hg.


Instruction: Canada recommends an SBP target of what?

Output: <120 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Canada recommends an SBP target of what?. ### Response: <120 mm Hg.


Instruction: The ACC/AHA guideline provides a table of equivalent BPvalues among what measures?

Output: standardized of ﬁce, home, daytime ambulatory,night-time ambulatory, and 24-hour ambulatory measure-ments

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The ACC/AHA guideline provides a table of equivalent BPvalues among what measures?. ### Response: standardized of ﬁce, home, daytime ambulatory,night-time ambulatory, and 24-hour ambulatory measure-ments.


Instruction: What determines the BP threshold with eachmeasurement technique that is associated with similar long-term outcomes in study populations?

Output: outcome-based approach

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What determines the BP threshold with eachmeasurement technique that is associated with similar long-term outcomes in study populations?. ### Response: outcome-based approach.


Instruction: Differences in BP values obtained using different measurementtechniques vary greatly among individual persons and even within a given individual over time?

Output: 160

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Differences in BP values obtained using different measurementtechniques vary greatly among individual persons and even within a given individual over time?. ### Response: 160.


Instruction: What did the KDIGO Work Group find no evidence of for any given in-dividual patient?

Output: one can reliably estimate the BP that would be obtainedunder standardized of ﬁce conditions from measurementstaken in any other settings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the KDIGO Work Group find no evidence of for any given in-dividual patient?. ### Response: one can reliably estimate the BP that would be obtainedunder standardized of ﬁce conditions from measurementstaken in any other settings.


Instruction: What was the best evidence-based approach?

Output: to usestandardized of ﬁce BP for management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the best evidence-based approach?. ### Response: to usestandardized of ﬁce BP for management.


Instruction: What is the best evidence-based approach to BP management?

Output: usestandardized

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the best evidence-based approach to BP management?. ### Response: usestandardized.


Instruction: What is risky to apply a therecommended SBP target of 120 mm Hg to?

Output: routine of ﬁce BPreadings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is risky to apply a therecommended SBP target of 120 mm Hg to?. ### Response: routine of ﬁce BPreadings.


Instruction: What index of sinus node function is isolated from autonomic control?

Output: Intrinsic heart rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What index of sinus node function is isolated from autonomic control?. ### Response: Intrinsic heart rate.


Instruction: What does Marcus B, Gillette PC, Garson A have in common with the intrinsic heart rate in children and young adults?

Output: an index of sinus node function isolated from autonomic control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Marcus B, Gillette PC, Garson A have in common with the intrinsic heart rate in children and young adults?. ### Response: an index of sinus node function isolated from autonomic control.


Instruction: What is the intrinsic heart rate in man?

Output: The normal range and determinants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the intrinsic heart rate in man?. ### Response: The normal range and determinants.


Instruction: What is induced by inappropriate sinus tachycardia?

Output: cardiomyopathy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is induced by inappropriate sinus tachycardia?. ### Response: cardiomyopathy.


Instruction: What was a case of cardiomyopathy induced by inappropriate sinus tachycardia and cured by ivabradine?

Output: Winum P-F

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a case of cardiomyopathy induced by inappropriate sinus tachycardia and cured by ivabradine?. ### Response: Winum P-F.


Instruction: What did Romeo E, Grimaldi N, Sarubbi B, et al. do?

Output: Efficacy of ivabradine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Romeo E, Grimaldi N, Sarubbi B, et al. do?. ### Response: Efficacy of ivabradine.


Instruction: What is BEAUTIFUL?

Output: a ran-domised, double-blind, placebo-controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is BEAUTIFUL?. ### Response: a ran-domised, double-blind, placebo-controlled trial.


Instruction: What is SHIFT?

Output: a randomised placebo-controlled study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SHIFT?. ### Response: a randomised placebo-controlled study.


Instruction: How is Ivabradine used in chronic heart failure?

Output: randomised placebo-controlled study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is Ivabradine used in chronic heart failure?. ### Response: randomised placebo-controlled study.


Instruction: What is ivabradine and outcomes in chronic heart failure?

Output: SHIFT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ivabradine and outcomes in chronic heart failure?. ### Response: SHIFT.


Instruction: What is the name of the randomised placebo-controlled study?

Output: SHIFT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised placebo-controlled study?. ### Response: SHIFT.


Instruction: When was the Lancet 376:875-85 published?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Lancet 376:875-85 published?. ### Response: 2010.


Instruction: What is the difference between ivabradine and metoprolol succinate in the treatment of sinus tachycardia?

Output: unresponsive to previous pharmacological therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between ivabradine and metoprolol succinate in the treatment of sinus tachycardia?. ### Response: unresponsive to previous pharmacological therapy.


Instruction: What is a crossover evaluation?

Output: Clinical efficacy of  ivabradine in patients with inappropriate sinus tachycardia: a prospective, random-ized, placebo-controlled, double-blind

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a crossover evaluation?. ### Response: Clinical efficacy of  ivabradine in patients with inappropriate sinus tachycardia: a prospective, random-ized, placebo-controlled, double-blind.


Instruction: What is the difference between metoprolol succinate and ivabradine in the treatment of inappropriate sinus tachycardia in patients unresponsive to previous pharmacological therapy?

Output: Efficacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between metoprolol succinate and ivabradine in the treatment of inappropriate sinus tachycardia in patients unresponsive to previous pharmacological therapy?. ### Response: Efficacy.


Instruction: Europace. 2013;15:116–21. 171.

Output: Metoprolol succinate vs. ivabradine in the treatment of inappropriate sinus tachycardia in pa-tients unresponsive to previous pharmacological therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Europace. 2013;15:116–21. 171.. ### Response: Metoprolol succinate vs. ivabradine in the treatment of inappropriate sinus tachycardia in pa-tients unresponsive to previous pharmacological therapy.


Instruction: What drug is used to treat inappropriate sinus Tachcardia after radiofrequency catheter ablation?

Output: ivabradine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug is used to treat inappropriate sinus Tachcardia after radiofrequency catheter ablation?. ### Response: ivabradine.


Instruction: What drug is used in combination with metoprolol succinate in the treatment of inappropriate sinus tachycardia?

Output: Ivabradine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug is used in combination with metoprolol succinate in the treatment of inappropriate sinus tachycardia?. ### Response: Ivabradine.


Instruction: How many patients were treated with radiofrequency catheter ablation?

Output: 171

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with radiofrequency catheter ablation?. ### Response: 171.


Instruction: How many patients with inappropriate sinus tachycardia were treated with ivabradine?

Output: four

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with inappropriate sinus tachycardia were treated with ivabradine?. ### Response: four.


Instruction: How long did the study last?

Output: three month

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the study last?. ### Response: three month.


Instruction: What was the outcome of the study?

Output: three month-long experience

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome of the study?. ### Response: three month-long experience.


Instruction: How long did it take to treat four patients with inappropriate sinus tachycardia?

Output: three month

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take to treat four patients with inappropriate sinus tachycardia?. ### Response: three month.


Instruction: How many patients were treated with ivabradine?

Output: four

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with ivabradine?. ### Response: four.


Instruction: What is the name of the drug used to treat all strokes?

Output: NOAC Aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used to treat all strokes?. ### Response: NOAC Aspirin.


Instruction: What is another name for Intracranial hem-orrhage?

Output: Major extracranialhemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for Intracranial hem-orrhage?. ### Response: Major extracranialhemorrhage.


Instruction: What is a major extracranialhemorrhage-M I- Vascular deathSRRCTsCohort studiesAs above NOAC Aspirin- Death- All stroke- Ischemic stroke- Systemicembolism- Intracranial hem-orrhea (subdural,subarachnoid, andintracerebral)1132 Evidence-Based Medicine (Continued)

Output: Death- All stroke- Ischemic stroke- Systemicembolism- Intracranial hem-orrhage (subdural,subarachnoid, andintracerebral)- Major extracranialhemorrhage-M I- Vascular deathSRRCTsCohort studies(Continued)1132 Evidence-Based Medicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a major extracranialhemorrhage-M I- Vascular deathSRRCTsCohort studiesAs above NOAC Aspirin- Death- All stroke- Ischemic stroke- Systemicembolism- Intracranial hem-orrhea (subdural,subarachnoid, andintracerebral)1132 Evidence-Based Medicine (Continued). ### Response: Death- All stroke- Ischemic stroke- Systemicembolism- Intracranial hem-orrhage (subdural,subarachnoid, andintracerebral)- Major extracranialhemorrhage-M I- Vascular deathSRRCTsCohort studies(Continued)1132 Evidence-Based Medicine.


Instruction: What is the name of the 2019 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation?

Output: Focused Update

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2019 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation?. ### Response: Focused Update.


Instruction: How many patients with atrial fibrillation were diagnosed in July 2018?

Output: 4.1.1, 4.2.2.2, 4.3, 4.4.1, 4.4.2, 6.1.1, 6.3.4, 7.4, 7.12

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with atrial fibrillation were diagnosed in July 2018?. ### Response: 4.1.1, 4.2.2.2, 4.3, 4.4.1, 4.4.2, 6.1.1, 6.3.4, 7.4, 7.12.


Instruction: Who was the Vice Chair of the University of Wisconsin-Madison?

Output: L. Samuel Wann

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the Vice Chair of the University of Wisconsin-Madison?. ### Response: L. Samuel Wann.


Instruction: Who is the Vice Chair of Columbia St. Mary’s Cardiovascular Physicians?

Output: L. Samuel Wann

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Vice Chair of Columbia St. Mary’s Cardiovascular Physicians?. ### Response: L. Samuel Wann.


Instruction: What is the name of the professor of medicine at John Hopkins Hospital?

Output: Hugh Calkins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor of medicine at John Hopkins Hospital?. ### Response: Hugh Calkins.


Instruction: Who is a director of electrophysiology at Johns Hopkins?

Output: Hugh Calkins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a director of electrophysiology at Johns Hopkins?. ### Response: Hugh Calkins.


Instruction: Which pharmaceutical company is Boehringer Ingelheim affiliated with?

Output: Bristol-Myers Squibb

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which pharmaceutical company is Boehringer Ingelheim affiliated with?. ### Response: Bristol-Myers Squibb.


Instruction: Who is the Associate Professor of Medicine at the University of Minnesota?

Output: Lin Y. Chen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Associate Professor of Medicine at the University of Minnesota?. ### Response: Lin Y. Chen.


Instruction: What is the name of the professor of medicine at Oregon Health and Science University?

Output: Joaquin E. Cigarroa

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor of medicine at Oregon Health and Science University?. ### Response: Joaquin E. Cigarroa.


Instruction: Who is a professor of medicine at the University of Colorado?

Output: Joseph C. Cleveland, Jr

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a professor of medicine at the University of Colorado?. ### Response: Joseph C. Cleveland, Jr.


Instruction: What is the division head of cardiology at the Knight Cardiovascular Institute?

Output: Joaquin E. Cigarroa

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the division head of cardiology at the Knight Cardiovascular Institute?. ### Response: Joaquin E. Cigarroa.


Instruction: Who is the Chief of Cardiac Surgery at Denver Veteran's Administration Hospital?

Output: Joseph C. Cleveland, Jr

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Chief of Cardiac Surgery at Denver Veteran's Administration Hospital?. ### Response: Joseph C. Cleveland, Jr.


Instruction: What is the name of the director of the Massachusetts General Hospital Heart Center?

Output: Patrick T. Ellinor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the director of the Massachusetts General Hospital Heart Center?. ### Response: Patrick T. Ellinor.


Instruction: Who is the Director of the Cardiac Arrhythmia Service?

Output: Bayer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Director of the Cardiac Arrhythmia Service?. ### Response: Bayer.


Instruction: Which medical college is located at Thomas Jefferson University?

Output: Sidney Kimmel Medical College

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which medical college is located at Thomas Jefferson University?. ### Response: Sidney Kimmel Medical College.


Instruction: Who is the professor of medicine at Thomas Jefferson University?

Output: Michael D. EzekowitzSidney Kimmel Medical College

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the professor of medicine at Thomas Jefferson University?. ### Response: Michael D. EzekowitzSidney Kimmel Medical College.


Instruction: What is the atending cardiologist at Bryn Mawr Hospital?

Output: Armetheon

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the atending cardiologist at Bryn Mawr Hospital?. ### Response: Armetheon.


Instruction: Which company is Boehringer Ingelheim affiliated with?

Output: Boston Scientific

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which company is Boehringer Ingelheim affiliated with?. ### Response: Boston Scientific.


Instruction: Who is the Associate Professor of Medicine at Ralph H. Johnson VA Medical Center?

Output: Michael E. Field Medical University of South Carolina

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Associate Professor of Medicine at Ralph H. Johnson VA Medical Center?. ### Response: Michael E. Field Medical University of South Carolina.


Instruction: What is the name of the company that owns Sanofi-aventis?

Output: Pfizer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the company that owns Sanofi-aventis?. ### Response: Pfizer.


Instruction: Who is the Chair of Neurology at Brown University?

Output: The Warren Alpert Medical School

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Chair of Neurology at Brown University?. ### Response: The Warren Alpert Medical School.


Instruction: What is the name of the Rhode Island hospital that is a neurologist-in-chief?

Output: Karen L. Furie

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Rhode Island hospital that is a neurologist-in-chief?. ### Response: Karen L. Furie.


Instruction: What does Foex BA say is possible in acute myocardial infarction?

Output: informed consent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Foex BA say is possible in acute myocardial infarction?. ### Response: informed consent.


Instruction: What does Williams BF, French JK, White HD say is not possible?

Output: informed consent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Williams BF, French JK, White HD say is not possible?. ### Response: informed consent.


Instruction: What is the HERO-2 consentsubstudy?

Output: a prospective observational study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the HERO-2 consentsubstudy?. ### Response: a prospective observational study.


Instruction: What is Task force 4?

Output: appropriateclinical care and issues of “self-referral

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Task force 4?. ### Response: appropriateclinical care and issues of “self-referral.


Instruction: When was Task Force 4 published?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Task Force 4 published?. ### Response: 2004.


Instruction: What is the ACCF/AHA/HRS/SCAIclinical competence statement on physician knowledge to optimizepatient safety and image quality in fluoroscopically guided invasivecardiovascular procedures?

Output: Task Force on Clinical Competence and Training

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ACCF/AHA/HRS/SCAIclinical competence statement on physician knowledge to optimizepatient safety and image quality in fluoroscopically guided invasivecardiovascular procedures?. ### Response: Task Force on Clinical Competence and Training.


Instruction: What is a report of the American College of Car-diology Foundation/American Heart Association/American College ofPhysicians Task Force on Clinical Competence and Training?

Output: ACCF/AHA/HRS/SCAIclinical competence statement on physician knowledge to optimizepatient safety and image quality in fluoroscopically guided invasivecardiovascular procedures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a report of the American College of Car-diology Foundation/American Heart Association/American College ofPhysicians Task Force on Clinical Competence and Training?. ### Response: ACCF/AHA/HRS/SCAIclinical competence statement on physician knowledge to optimizepatient safety and image quality in fluoroscopically guided invasivecardiovascular procedures.


Instruction: What is the name of the Task Force on Clinical Competence and Training?

Output: Car-diology Foundation/American Heart Association/American College ofPhysicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Clinical Competence and Training?. ### Response: Car-diology Foundation/American Heart Association/American College ofPhysicians.


Instruction: When was the Circu-lation.111:511–32.317 published?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circu-lation.111:511–32.317 published?. ### Response: 2005.


Instruction: What is a safety program for the cardiac catheterization laboratory?

Output: Radiation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a safety program for the cardiac catheterization laboratory?. ### Response: Radiation.


Instruction: Where was the Deleted in proof.319.

Output: Catheter Cardiovasc Interv. 2011;77:546–56.318. Deleted in proof.319. Deleted in proof.320

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where was the Deleted in proof.319.. ### Response: Catheter Cardiovasc Interv. 2011;77:546–56.318. Deleted in proof.319. Deleted in proof.320.


Instruction: What is the name of the randomized trial of inpatient vsoutpatient hydration protocols in mild-to-moderate renal dysfunction?

Output: PREPARED

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized trial of inpatient vsoutpatient hydration protocols in mild-to-moderate renal dysfunction?. ### Response: PREPARED.


Instruction: What did Taylor AJ, Hotchkiss D, Morse RW, et al. do?

Output: PREPARED: Preparation forAngiography in Renal Dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Taylor AJ, Hotchkiss D, Morse RW, et al. do?. ### Response: PREPARED: Preparation forAngiography in Renal Dysfunction.


Instruction: What does REINFORCE stand for?

Output: Renal InsufficiencyFollowing Radiocontrast Exposure Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does REINFORCE stand for?. ### Response: Renal InsufficiencyFollowing Radiocontrast Exposure Trial.


Instruction: What is the name of the randomized trial that compares sodium bicarbonate and sodium chloride?

Output: INFORCE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized trial that compares sodium bicarbonate and sodium chloride?. ### Response: INFORCE.


Instruction: What is the difference between sodium bicarbonate and sodiumchloride for the prevention of contrast medium-induced nephropathy inpatientsundergoing coronary angiography?

Output: comparison of sodium bicarbonate versus sodium chlo-ride hydrationfor the prevention of contrast-induced nephropathy. Coron Artery Dis.2008;19:413–9.323. Brar SS, Shen AY, Jorgensen MB, et al. Sodium bicarbonate vs sodiumchloride for the prevention of contrast medium-induced nephropathy inpatients undergoing coronary angiography: a randomized trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between sodium bicarbonate and sodiumchloride for the prevention of contrast medium-induced nephropathy inpatientsundergoing coronary angiography?. ### Response: comparison of sodium bicarbonate versus sodium chlo-ride hydrationfor the prevention of contrast-induced nephropathy. Coron Artery Dis.2008;19:413–9.323. Brar SS, Shen AY, Jorgensen MB, et al. Sodium bicarbonate vs sodiumchloride for the prevention of contrast medium-induced nephropathy inpatients undergoing coronary angiography: a randomized trial.


Instruction: What is a systematic review and meta-analysis?

Output: Sodium bicarbonate for theprevention of contrast induced-acute kidney injury

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a systematic review and meta-analysis?. ### Response: Sodium bicarbonate for theprevention of contrast induced-acute kidney injury.


Instruction: What is the name of the randomized com-parison of 3 preventive strategies?

Output: Renal Insufficiency FollowingContrast Media Administration Trial (REMEDIAL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized com-parison of 3 preventive strategies?. ### Response: Renal Insufficiency FollowingContrast Media Administration Trial (REMEDIAL.


Instruction: What is Sodium bicarbonate associated with?

Output: an increased incidence of contrast nephropathy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Sodium bicarbonate associated with?. ### Response: an increased incidence of contrast nephropathy.


Instruction: What is associated with an increased incidence of contrast nephropathy?

Output: Sodium bicarbonate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with an increased incidence of contrast nephropathy?. ### Response: Sodium bicarbonate.


Instruction: How many patients were enrolled in a ret-rospective cohort study of sodium bicarbonate at Mayo Clinic?

Output: 7977

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were enrolled in a ret-rospective cohort study of sodium bicarbonate at Mayo Clinic?. ### Response: 7977.


Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al.


Instruction: What is the date of publication of the 2021 Circulation. 2021:143:e72–e227?

Output: February 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the date of publication of the 2021 Circulation. 2021:143:e72–e227?. ### Response: February 2.


Instruction: Who is the Chair-Elect of the JOINT COMMITTEE?

Output: Joshua A. Beckman

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Chair-Elect of the JOINT COMMITTEE?. ### Response: Joshua A. Beckman.


Instruction: Who is Glenn N. Levine?

Output: MD, FACC, FAHA, Immediate Past Chair*

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Glenn N. Levine?. ### Response: MD, FACC, FAHA, Immediate Past Chair*.


Instruction: Who is Sana M. Al-Khatib?

Output: Immediate Past Chair*

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Sana M. Al-Khatib?. ### Response: Immediate Past Chair*.


Instruction: Anastasia Arm-bruster is PharmD, AACC; what is Kim K. Birtcher?

Output: PharmD, MS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Anastasia Arm-bruster is PharmD, AACC; what is Kim K. Birtcher?. ### Response: PharmD, MS.


Instruction: Who is the MD, FACC, FAHA*; Lisa de las Fuentes, MD, MSc, FASE; Federico Gentile, MD?

Output: Joaquin Ciggaroa

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the MD, FACC, FAHA*; Lisa de las Fuentes, MD, MSc, FASE; Federico Gentile, MD?. ### Response: Joaquin Ciggaroa.


Instruction: What is the MPH of Norisa Haynes?

Output: MD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the MPH of Norisa Haynes?. ### Response: MD.


Instruction: Where is Mark A. Hlatky?

Output: MD, FACC, FAHA*

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Mark A. Hlatky?. ### Response: MD, FACC, FAHA*.


Instruction: Who is Mark A. Hlatky?

Output: MD, FACC, FAHA*

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Mark A. Hlatky?. ### Response: MD, FACC, FAHA*.


Instruction: Who is José A. Joglar?

Output: MD, FACC, FAHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is José A. Joglar?. ### Response: MD, FACC, FAHA.


Instruction: What is Daniel Mark's specialty?

Output: MD, MPH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Daniel Mark's specialty?. ### Response: MD, MPH.


Instruction: Who is the President of the American College of Cardiology?

Output: Athena Poppas

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the President of the American College of Cardiology?. ### Response: Athena Poppas.


Instruction: What is the title of the Chief Science and Quality Officer?

Output: MD, PhD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of the Chief Science and Quality Officer?. ### Response: MD, PhD.


Instruction: Who is the Senior Director of Science, Education, Quality and Publishing?

Output: MaryAnne Elma

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Senior Director of Science, Education, Quality and Publishing?. ### Response: MaryAnne Elma.


Instruction: What is the name of the person who leads the Clinical Policy Publications team?

Output: Grace D. Ronan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the person who leads the Clinical Policy Publications team?. ### Response: Grace D. Ronan.


Instruction: Which doctor is the Director of Guideline Strategy and Operations?

Output: Thomas S. D. Getchius

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which doctor is the Director of Guideline Strategy and Operations?. ### Response: Thomas S. D. Getchius.


Instruction: Who is the Director of Guideline Science and Methodology?

Output: Abdul R. Abdullah, MD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Director of Guideline Science and Methodology?. ### Response: Abdul R. Abdullah, MD.


Instruction: What is the name of the advisor for the American Heart Association?

Output: Laura Mitchell

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the advisor for the American Heart Association?. ### Response: Laura Mitchell.


Instruction: Who is a Vice President of Office of Science, Medicine and Health?

Output: Radhika Rajgopal Singh

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a Vice President of Office of Science, Medicine and Health?. ### Response: Radhika Rajgopal Singh.


Instruction: Who is the Senior Science and Medicine Advisor at the Office of Science, Medicine and Health?

Output: Paul St. Laurent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Senior Science and Medicine Advisor at the Office of Science, Medicine and Health?. ### Response: Paul St. Laurent.


Instruction: When was the document approved by the American College of Cardiology Clinical Policy Approval Committee?

Output: August 2020

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the document approved by the American College of Cardiology Clinical Policy Approval Committee?. ### Response: August 2020.


Instruction: When will the American Heart Association Science Advisory and Coordinating Committee meet?

Output: August 2020

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When will the American Heart Association Science Advisory and Coordinating Committee meet?. ### Response: August 2020.


Instruction: When is the Comprehensive RWI Data Supplement table available with this article?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is the Comprehensive RWI Data Supplement table available with this article?. ### Response: https://www.ahajournals.org.


Instruction: What journal has this article been copublished in?

Output: Journal of the American College of Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What journal has this article been copublished in?. ### Response: Journal of the American College of Cardiology.


Instruction: Where can you find additional materials for this article?

Output: https://www.ahajournals.org/doi/suppl/10.1161/CIR.0000000000000923This article has been copublished in Journal of the American College of Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find additional materials for this article?. ### Response: https://www.ahajournals.org/doi/suppl/10.1161/CIR.0000000000000923This article has been copublished in Journal of the American College of Cardiology.


Instruction: What are some of the cardiac conditions that are associated with an increased risk for stroke?

Output: MI, cardiomyopathy, valvular heart disease, PFO and ASAs, cardiac tumors, and aortic ath-erosclerosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the cardiac conditions that are associated with an increased risk for stroke?. ### Response: MI, cardiomyopathy, valvular heart disease, PFO and ASAs, cardiac tumors, and aortic ath-erosclerosis.


Instruction: What is based on well-reasoned consensus of opinion?

Output: Therapies to prevent stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is based on well-reasoned consensus of opinion?. ### Response: Therapies to prevent stroke.


Instruction: Randomized, prospective trials to prevent stroke in many of these conditions are what?

Output: often lacking

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Randomized, prospective trials to prevent stroke in many of these conditions are what?. ### Response: often lacking.


Instruction: What is often lacking to support these decisions?

Output: prospective trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is often lacking to support these decisions?. ### Response: prospective trials.


Instruction: What is reasonable for patients with STEMI and left ventricular mural thrombi?

Output: therapy with a vitamin K antagonist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable for patients with STEMI and left ventricular mural thrombi?. ### Response: therapy with a vitamin K antagonist.


Instruction: Clinical trials could inform what?

Output: the duration of treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Clinical trials could inform what?. ### Response: the duration of treatment.


Instruction: What is lacking to determine whether antithrombotic therapy is useful for the primary prevention of stroke in patients with mitral valve prolapse and mitral regurgitation who don't have AF?

Output: Prospective trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is lacking to determine whether antithrombotic therapy is useful for the primary prevention of stroke in patients with mitral valve prolapse and mitral regurgitation who don't have AF?. ### Response: Prospective trials.


Instruction: What would be useful to determine which would be most effective in reducing stroke?

Output: Comparative-effectiveness trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would be useful to determine which would be most effective in reducing stroke?. ### Response: Comparative-effectiveness trials.