Instruction: Comprehensive cardiac screening including 12-lead ECG, possible signal averaged, echocardiogram, and exercise testing of first-degree relatives of decedents with sudden unexpected death may identify a probable heritable condition?

Output: up to 30% of cases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Comprehensive cardiac screening including 12-lead ECG, possible signal averaged, echocardiogram, and exercise testing of first-degree relatives of decedents with sudden unexpected death may identify a probable heritable condition?. ### Response: up to 30% of cases.


Instruction: How much of sudden unexpected death may identify a probable heritable cardiac cause of death?

Output: up to 30%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of sudden unexpected death may identify a probable heritable cardiac cause of death?. ### Response: up to 30%.


Instruction: What should be targeted based on the results of initial evaluation?

Output: Genetic testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be targeted based on the results of initial evaluation?. ### Response: Genetic testing.


Instruction: Genetic testing in selected first-degree relatives may result in what?

Output: identification of inherited conditions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Genetic testing in selected first-degree relatives may result in what?. ### Response: identification of inherited conditions.


Instruction: What percentage of families have HCM?

Output: 4% to 30%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of families have HCM?. ### Response: 4% to 30%.


Instruction: What is important to use for family risk profiling?

Output: disease-specific genetic test panel that corresponds to the autopsy findings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is important to use for family risk profiling?. ### Response: disease-specific genetic test panel that corresponds to the autopsy findings.


Instruction: What type of test corresponds to the autopsy findings?

Output: disease-specific genetic test

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of test corresponds to the autopsy findings?. ### Response: disease-specific genetic test.


Instruction: What is important in risk profiling of family members of an SCD victim?

Output: disease-specific genetic test panel that corresponds to the autopsy findings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is important in risk profiling of family members of an SCD victim?. ### Response: disease-specific genetic test panel that corresponds to the autopsy findings.


Instruction: Phenotyping of surviving family members is crucial in what?

Output: family risk profiling

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Phenotyping of surviving family members is crucial in what?. ### Response: family risk profiling.


Instruction: How does genotyping of the SCD proband provide a mechanism for efficient follow-up evaluation?

Output: phenotyping of surviving family members is crucial, genotyp-ing of the SCD proband provides a mechanism for efficient follow-up evaluation of those rela-tives with the disease-causing mutation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does genotyping of the SCD proband provide a mechanism for efficient follow-up evaluation?. ### Response: phenotyping of surviving family members is crucial, genotyp-ing of the SCD proband provides a mechanism for efficient follow-up evaluation of those rela-tives with the disease-causing mutation.


Instruction: What provides a mechanism for efficient follow-up evaluation of those rela-tives with the disease-causing mutation found?

Output: genotyp-ing of the SCD proband

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What provides a mechanism for efficient follow-up evaluation of those rela-tives with the disease-causing mutation found?. ### Response: genotyp-ing of the SCD proband.


Instruction: When was SCD proband downloaded from http://ahajournals.org?

Output: April 23, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was SCD proband downloaded from http://ahajournals.org?. ### Response: April 23, 2023.


Instruction: What year did Neurosurg Rev. 2017:40:45–51?

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Neurosurg Rev. 2017:40:45–51?. ### Response: 2017.


Instruction: What is the name of the disease that recently symptomatic carotid ar -tery stenosis has?

Output: intracranial artery stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease that recently symptomatic carotid ar -tery stenosis has?. ### Response: intracranial artery stenosis.


Instruction: When did Cochrane Database Syst Rev. 2016:9:CD011401 release?

Output: 14651858

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Cochrane Database Syst Rev. 2016:9:CD011401 release?. ### Response: 14651858.


Instruction: How many patients were treated with the North American Symptomatic Carotid Endarterectomy Trial?

Output: 1415

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with the North American Symptomatic Carotid Endarterectomy Trial?. ### Response: 1415.


Instruction: What is the name of the trial that evaluated surgical results in 1415 patients?

Output: The North American Symptomatic Carotid Endarterectomy Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the trial that evaluated surgical results in 1415 patients?. ### Response: The North American Symptomatic Carotid Endarterectomy Trial.


Instruction: When did Stroke. 1999;30:1751–1758?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Stroke. 1999;30:1751–1758?. ### Response: 1999.


Instruction: What is a symptomatic intracranial arterial stenosis?

Output: warfarin and aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a symptomatic intracranial arterial stenosis?. ### Response: warfarin and aspirin.


Instruction: What is the name of the study that compares warfarin and aspirin?

Output: Warfarin-Aspirin Symptomatic Intracranial Disease Trial Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that compares warfarin and aspirin?. ### Response: Warfarin-Aspirin Symptomatic Intracranial Disease Trial Investigators.


Instruction: How many pages were in 2005?

Output: 1305–1316

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many pages were in 2005?. ### Response: 1305–1316.


Instruction: What is the name of the trial investigators that investigated stenting versus aggressive medical therapy for in-tracranial arterial stenosis?

Output: SAMMPRIS Trial Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the trial investigators that investigated stenting versus aggressive medical therapy for in-tracranial arterial stenosis?. ### Response: SAMMPRIS Trial Investigators.


Instruction: What year did N Engl J Med issue 365:993-1003?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did N Engl J Med issue 365:993-1003?. ### Response: 2011.


Instruction: Who was the SAMMPRIS Trial Investigator?

Output: Chaturvedi S

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the SAMMPRIS Trial Investigator?. ### Response: Chaturvedi S.


Instruction: What does stenting and aggressive medical management help prevent?

Output: Recurrent Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does stenting and aggressive medical management help prevent?. ### Response: Recurrent Stroke.


Instruction: What is the name of the trial investigators that used stetting to prevent recurrent stroke?

Output: SAMMPRIS Trial Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the trial investigators that used stetting to prevent recurrent stroke?. ### Response: SAMMPRIS Trial Investigators.


Instruction: What is SAMMPRIS?

Output: the final results of a randomised trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SAMMPRIS?. ### Response: the final results of a randomised trial.


Instruction: What is the final result of a randomised trial in high-risk patients with intracranial artery stenosis?

Output: Aggressive medical treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the final result of a randomised trial in high-risk patients with intracranial artery stenosis?. ### Response: Aggressive medical treatment.


Instruction: Who are the SAMMPRIS Investigators?

Output: Lutsep HL, Barnwell SL, Larsen DT, Lynn MJ, Hong M, Turan TN, Derdeyn CP, Fiorella D, Janis LS, Chimowitz MI; for the SAMMPRIS Investigators. Outcome in patients previously on antithrombotic therapy in the SAMMPRIS trial: subgroup analysis. Stroke. 2015;46:775–779. doi: 10.1161/STROKEAHA.114.007752 339. Chaturvedi S, Turan TN, Lynn MJ, Derdeyn CP, Fiorella D, Janis LS, Chimowitz MI; for the SAMMPRIS Trial Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who are the SAMMPRIS Investigators?. ### Response: Lutsep HL, Barnwell SL, Larsen DT, Lynn MJ, Hong M, Turan TN, Derdeyn CP, Fiorella D, Janis LS, Chimowitz MI; for the SAMMPRIS Investigators. Outcome in patients previously on antithrombotic therapy in the SAMMPRIS trial: subgroup analysis. Stroke. 2015;46:775–779. doi: 10.1161/STROKEAHA.114.007752 339. Chaturvedi S, Turan TN, Lynn MJ, Derdeyn CP, Fiorella D, Janis LS, Chimowitz MI; for the SAMMPRIS Trial Investigators.


Instruction: What was the outcome in patients previously on antithrombotic therapy?

Output: Immediate versus delayed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome in patients previously on antithrombotic therapy?. ### Response: Immediate versus delayed.


Instruction: How did the outcome compare to other patients?

Output: patient char -acteristics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did the outcome compare to other patients?. ### Response: patient char -acteristics.


Instruction: Who were the investigators for?

Output: SAMMPRIS Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who were the investigators for?. ### Response: SAMMPRIS Investigators.


Instruction: What is the acronym for the SAMMPRIS Trial Investigators?

Output: pirin Symptomatic Intracranial Disease Trial Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the SAMMPRIS Trial Investigators?. ### Response: pirin Symptomatic Intracranial Disease Trial Investigators.


Instruction: Do patient char -acteristics explain the differences in outcome between medically treated patients?

Output: Do patient char -acteristics explain the differences in outcome between medically treated patients in SAMMPRIS and WASID

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Do patient char -acteristics explain the differences in outcome between medically treated patients?. ### Response: Do patient char -acteristics explain the differences in outcome between medically treated patients in SAMMPRIS and WASID.


Instruction: Stroke. 2015;46:2562–2567.

Output: patient char -acteristics explain the differences in outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Stroke. 2015;46:2562–2567.. ### Response: patient char -acteristics explain the differences in outcome.


Instruction: What is the name of the systematic, prospec-tive analysis of serious cardiac arrhythmias after stroke?

Output: North American Symptomatic Carotid Endarterectomy Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic, prospec-tive analysis of serious cardiac arrhythmias after stroke?. ### Response: North American Symptomatic Carotid Endarterectomy Trial.


Instruction: When did Stroke.43:2892-2897 occur?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Stroke.43:2892-2897 occur?. ### Response: 2012.


Instruction: What is a common cause of heart failure?

Output: carotid ar -tery stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a common cause of heart failure?. ### Response: carotid ar -tery stenosis.


Instruction: Where are heart failures diagnosed?

Output: Lancet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are heart failures diagnosed?. ### Response: Lancet.


Instruction: What are cardiac arrhythmias in stroke unit patients evaluated for?

Output: cardiac monitoring data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are cardiac arrhythmias in stroke unit patients evaluated for?. ### Response: cardiac monitoring data.


Instruction: What is the name of the study that evaluated cardiac monitoring data?

Output: Neurologia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated cardiac monitoring data?. ### Response: Neurologia.


Instruction: What does not necessarily reflect relationships with industry at the time of publication?

Output: The table

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not necessarily reflect relationships with industry at the time of publication?. ### Response: The table.


Instruction: What is deemed to have a significant interest in a business if the interest represents ownership of 5% of the voting stock or share of the business entity?

Output: A person

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is deemed to have a significant interest in a business if the interest represents ownership of 5% of the voting stock or share of the business entity?. ### Response: A person.


Instruction: How much of the fair market value of the business entity does a person own?

Output: $5 000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the fair market value of the business entity does a person own?. ### Response: $5 000.


Instruction: What percentage of the person's gross income for the previous year does the amount of funds received by a business entity exceed?

Output: 5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the person's gross income for the previous year does the amount of funds received by a business entity exceed?. ### Response: 5%.


Instruction: Relationships that exist with no financial benefit are also included in what category?

Output: transparency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Relationships that exist with no financial benefit are also included in what category?. ### Response: transparency.


Instruction: What are relationships that exist with no financial benefit included for the purpose of transparency?

Output: Relationships in this table are modest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are relationships that exist with no financial benefit included for the purpose of transparency?. ### Response: Relationships in this table are modest.


Instruction: Relationships in this table are modest unless otherwise noted?

Output: Relationships that exist with no financial benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Relationships in this table are modest unless otherwise noted?. ### Response: Relationships that exist with no financial benefit.


Instruction: According to the ACC/AHA, a person has a relevant relationship if: a) the relationship or interest relates to the same or similar subject matter, intellectual property or what else?

Output: asset, topic, or issue addressed in the document

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: According to the ACC/AHA, a person has a relevant relationship if: a) the relationship or interest relates to the same or similar subject matter, intellectual property or what else?. ### Response: asset, topic, or issue addressed in the document.


Instruction: What does the company/entity make a drug, drug class, or device addressed in the document?

Output: a competing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the company/entity make a drug, drug class, or device addressed in the document?. ### Response: a competing.


Instruction: What is the name of the company or entity with whom the relationship exists?

Output: the company

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the company or entity with whom the relationship exists?. ### Response: the company.


Instruction: What type of drug or device is addressed in the document?

Output: competing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of drug or device is addressed in the document?. ### Response: competing.


Instruction: Who has a reasonable potential for financial, professional or other personal gain or loss as a result of the issues/content addressed?

Output: the person or a member of the person’s household

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who has a reasonable potential for financial, professional or other personal gain or loss as a result of the issues/content addressed?. ### Response: the person or a member of the person’s household.


Instruction: What indicates American College of Cardiology?

Output: ACC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates American College of Cardiology?. ### Response: ACC.


Instruction: AHA indicates American Heart Association.

Output: ACC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: AHA indicates American Heart Association.. ### Response: ACC.


Instruction: What is the acronym for the American College of Cardiology?

Output: ACC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the American College of Cardiology?. ### Response: ACC.


Instruction: What does AHA stand for?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does AHA stand for?. ### Response: American Heart Association.


Instruction: Where does LLP stand for Limited Liability Partnership?

Output: LLP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where does LLP stand for Limited Liability Partnership?. ### Response: LLP.


Instruction: What is the name of the person who is a BureauOwnershipPartnership/PrincipalPersonal ResearchInstitutional, Organizational, or Other Financial BenefitExpert WitnessDownloaded from http://ahajournals.org by on May 1, 2023?

Output: ContinuedCommittee Member Employment ConsultantSpeakers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the person who is a BureauOwnershipPartnership/PrincipalPersonal ResearchInstitutional, Organizational, or Other Financial BenefitExpert WitnessDownloaded from http://ahajournals.org by on May 1, 2023?. ### Response: ContinuedCommittee Member Employment ConsultantSpeakers.


Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020 Page 43 of 127 Recommendation 18?

Output: For primary prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020 Page 43 of 127 Recommendation 18?. ### Response: For primary prevention.


Instruction: What is insufficient evidence to recommend for or against icosapent ethyl in patients on statin therapy?

Output: persistently elevated fasting triglycerides

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is insufficient evidence to recommend for or against icosapent ethyl in patients on statin therapy?. ### Response: persistently elevated fasting triglycerides.


Instruction: Patients on statin therapy with persistently elevated fasting triglycerides should take what for secondary prevention?

Output: icosapent ethyl

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients on statin therapy with persistently elevated fasting triglycerides should take what for secondary prevention?. ### Response: icosapent ethyl.


Instruction: What is icosapent ethyl meant to reduce?

Output: cardiovascular morbidity and mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is icosapent ethyl meant to reduce?. ### Response: cardiovascular morbidity and mortality.


Instruction: What is Icosapent ethy l purified from?

Output: omega- 3 fatty acid eicosapentaenoic acid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Icosapent ethy l purified from?. ### Response: omega- 3 fatty acid eicosapentaenoic acid.


Instruction: What is the omega-3 fatty acid EPA?

Output: eicosapentaenoic acid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the omega-3 fatty acid EPA?. ### Response: eicosapentaenoic acid.


Instruction: What was the body of evidence examining the potential effects of icosapent ethyl on critical CV outcomes limited to?

Output: a single randomized trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the body of evidence examining the potential effects of icosapent ethyl on critical CV outcomes limited to?. ### Response: a single randomized trial.


Instruction: What was limited to a single randomized trial?

Output: the body of evidence examining the potential effects of icosapent ethyl on critical CV outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was limited to a single randomized trial?. ### Response: the body of evidence examining the potential effects of icosapent ethyl on critical CV outcomes.


Instruction: Who conducted a double-blind, placebo -controlled trial in 2019?

Output: Bhatt et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who conducted a double-blind, placebo -controlled trial in 2019?. ### Response: Bhatt et al.


Instruction: What is REDUCE -IT?

Output: Reduction of Cardiovascular Events With Icosapent Ethyl -Intervention Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is REDUCE -IT?. ### Response: Reduction of Cardiovascular Events With Icosapent Ethyl -Intervention Trial.


Instruction: How much did treatment with 4 grams of icosapent ethyl result in?

Output: 25% reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much did treatment with 4 grams of icosapent ethyl result in?. ### Response: 25% reduction.


Instruction: What is the primary endpoint defined as?

Output: prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary endpoint defined as?. ### Response: prevention.


Instruction: How long did it take for a non- fatal stroke to occur?

Output: 4.9 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for a non- fatal stroke to occur?. ### Response: 4.9 years.


Instruction: What percentage of the subjects in the study were high risk patients?

Output: 70%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the subjects in the study were high risk patients?. ### Response: 70%.


Instruction: What percentage of the enrolled patients had a history of CVD?

Output: 70%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the enrolled patients had a history of CVD?. ### Response: 70%.


Instruction: What was a minority of the patients enrolled in the primary prevention cohort?

Output: patients without a history of atherosclerotic CVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a minority of the patients enrolled in the primary prevention cohort?. ### Response: patients without a history of atherosclerotic CVD.


Instruction: How did the Work Group determine that the REDUCE -IT results alone are insufficient to show a difference in CV outcomes?

Output: a subgroup analysis of the primary prevention cohort

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did the Work Group determine that the REDUCE -IT results alone are insufficient to show a difference in CV outcomes?. ### Response: a subgroup analysis of the primary prevention cohort.


Instruction: What are the results of REDUCE -IT insufficient to suggest?

Output: icosapent ethyl

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of REDUCE -IT insufficient to suggest?. ### Response: icosapent ethyl.


Instruction: What is applicable to many patients classified as high risk by virtue of a history of CVD?

Output: The results from REDUCE -IT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is applicable to many patients classified as high risk by virtue of a history of CVD?. ### Response: The results from REDUCE -IT.


Instruction: What percentage of patients had TG levels above 150 mg/dL?

Output: 90%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients had TG levels above 150 mg/dL?. ### Response: 90%.


Instruction: What was the median TG level in patients with CVD?

Output: 216 mg/dL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the median TG level in patients with CVD?. ### Response: 216 mg/dL.


Instruction: How much of the patients with TG were on medication?

Output: 90%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the patients with TG were on medication?. ### Response: 90%.


Instruction: What percentage of patients were on stable doses of moderate to high dose statins for at least four weeks before the intervention?

Output: 90%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients were on stable doses of moderate to high dose statins for at least four weeks before the intervention?. ### Response: 90%.


Instruction: What percentage reduction in CVD outcomes pertains to secondary prevention populations on statin therapy with hypertriglyceridemia?

Output: 25%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage reduction in CVD outcomes pertains to secondary prevention populations on statin therapy with hypertriglyceridemia?. ### Response: 25%.


Instruction: What was the composite outcome of statin therapy with hypertriglyceridemia?

Output: coronary revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the composite outcome of statin therapy with hypertriglyceridemia?. ### Response: coronary revascularization.


Instruction: What is a less clinically valid outcome for some patients?

Output: coronary revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a less clinically valid outcome for some patients?. ### Response: coronary revascularization.


Instruction: What is the name of the reference list for Chronic Heart Failure?

Output: NICE 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the reference list for Chronic Heart Failure?. ### Response: NICE 2018.


Instruction: Who is the author of this reference list?

Output: NICE 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of this reference list?. ### Response: NICE 2018.


Instruction: How does remote telemedical management affect mortality?

Output: Impact of remote telemedical management on mortality and hospitalizations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does remote telemedical management affect mortality?. ### Response: Impact of remote telemedical management on mortality and hospitalizations.


Instruction: What is the impact of remote telemedical management on mortality and hospitalizations in ambulatory patients with chronic heart failure?

Output: telemedical interventional monitoring in heart failure study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact of remote telemedical management on mortality and hospitalizations in ambulatory patients with chronic heart failure?. ### Response: telemedical interventional monitoring in heart failure study.


Instruction: What was the name of the study?

Output: EMPHASIS -HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the study?. ### Response: EMPHASIS -HF.


Instruction: What is HEAAL?

Output: a randomised, double -blind trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is HEAAL?. ### Response: a randomised, double -blind trial.


Instruction: What is the name of the randomised, double-blind trial?

Output: HEAAL study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised, double-blind trial?. ### Response: HEAAL study.


Instruction: What are the benefits of Beta-Blockers in patients with heart failure?

Output: Heart Rate and Rhythm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the benefits of Beta-Blockers in patients with heart failure?. ### Response: Heart Rate and Rhythm.


Instruction: What is the Journal of the American College of Cardiology?

Output: 201 7; 69(24):2885 -2896  181

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Journal of the American College of Cardiology?. ### Response: 201 7; 69(24):2885 -2896  181.


Instruction: What does Holmes J, Krum H, Altman DG, Manzano L, Cleland JG et al. do?

Output: Efficacy of beta blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Holmes J, Krum H, Altman DG, Manzano L, Cleland JG et al. do?. ### Response: Efficacy of beta blockers.


Instruction: What is the effect of beta blockers in patients with heart failure plus atrial fibrillation?

Output: Efficacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of beta blockers in patients with heart failure plus atrial fibrillation?. ### Response: Efficacy.


Instruction: When was the Lancet 384(9961):2235 -43 182?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Lancet 384(9961):2235 -43 182?. ### Response: 2014.


Instruction: What are the views of nurses on deactivation of pacemakers and implantable cardioverter-defibrillators?

Output: Just because we can doesn't mean we should":

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the views of nurses on deactivation of pacemakers and implantable cardioverter-defibrillators?. ### Response: Just because we can doesn't mean we should":.


Instruction: Journal of Interventional Cardiac Electrophysiology. 2011; 32(3):243 -52 183.

Output: emakers and implantable cardioverter -defibrillators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Journal of Interventional Cardiac Electrophysiology. 2011; 32(3):243 -52 183.. ### Response: emakers and implantable cardioverter -defibrillators.


Instruction: What is the acronym for the Chronic Heart Failure Assessment by Telephone study?

Output: CHAT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the Chronic Heart Failure Assessment by Telephone study?. ### Response: CHAT.


Instruction: What does CHAT stand for?

Output: Chronic Heart Failure Assessment by Telephone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CHAT stand for?. ### Response: Chronic Heart Failure Assessment by Telephone.


Instruction: What is the clinical benefit of eplerenone in patients with mild symptoms of systolic heart failure already receiving optimal best practice background drug therapy?

Output: an alysis of the EMPHASIS -HF study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the clinical benefit of eplerenone in patients with mild symptoms of systolic heart failure already receiving optimal best practice background drug therapy?. ### Response: an alysis of the EMPHASIS -HF study.


Instruction: Circulation: Heart Failure. 2013; 6(4):711 -718 185.

Output: isen DJ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation: Heart Failure. 2013; 6(4):711 -718 185.. ### Response: isen DJ.


Instruction: What is the EMPHASIS -HF study?

Output: Clinical benefit of eplerenone in patients with mild symptoms of systolic heart failure already receiving optimal best practice background drug therapy: an alysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the EMPHASIS -HF study?. ### Response: Clinical benefit of eplerenone in patients with mild symptoms of systolic heart failure already receiving optimal best practice background drug therapy: an alysis.


Instruction: What are the results of the 2013 Circulation: Heart Failure?

Output: 711 -718 185

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of the 2013 Circulation: Heart Failure?. ### Response: 711 -718 185.


Instruction: How is heart failure therapy guided by plasma BNP concentrations?

Output: Optimalization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is heart failure therapy guided by plasma BNP concentrations?. ### Response: Optimalization.


Instruction: What are multiple biomarkers for risk prediction in chronic heart failure?

Output: beta blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are multiple biomarkers for risk prediction in chronic heart failure?. ### Response: beta blockers.


Instruction: Circulation: Heart Failure. 2012; 5(2):183 -90 187 What is on your health care team?

Output: LaDonna KA, Bates J, Tait GR, McDougall A, Schulz V, Lingard L

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation: Heart Failure. 2012; 5(2):183 -90 187 What is on your health care team?. ### Response: LaDonna KA, Bates J, Tait GR, McDougall A, Schulz V, Lingard L.


Instruction: What does NT-proBNP do?

Output: guided drug treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does NT-proBNP do?. ### Response: guided drug treatment.


Instruction: What is the name of the drug used for chronic heart failure?

Output: NT-proBNP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used for chronic heart failure?. ### Response: NT-proBNP.


Instruction: What was the name of the trial that was used to treat chronic heart failure?

Output: BATTLESCARRED

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the trial that was used to treat chronic heart failure?. ### Response: BATTLESCARRED.


Instruction: What is the European Journal of Heart Failure's 2006 edition of the "BATTLESCARRED" trial?

Output: 8(5):532 -8 189

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the European Journal of Heart Failure's 2006 edition of the "BATTLESCARRED" trial?. ### Response: 8(5):532 -8 189.


Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al.


Instruction: When did Otto and colleagues publish their guideline?

Output: February 2, 2021

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Otto and colleagues publish their guideline?. ### Response: February 2, 2021.


Instruction: What is a benefit of AVR in severe high-gradi-ent AS?

Output: survival, symp-toms, and LV systolic function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a benefit of AVR in severe high-gradi-ent AS?. ### Response: survival, symp-toms, and LV systolic function.


Instruction: What is the most common initial symptom of AS?

Output: exertional dys-pnea or decreased exercise tolerance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common initial symptom of AS?. ### Response: exertional dys-pnea or decreased exercise tolerance.


Instruction: What is needed to recognize early symptoms and proceed promptly to AVR?

Output: Clinical vigilance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed to recognize early symptoms and proceed promptly to AVR?. ### Response: Clinical vigilance.


Instruction: HF, syncope, and angina are examples of what?

Output: More severe “classical” symptoms of AS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: HF, syncope, and angina are examples of what?. ### Response: More severe “classical” symptoms of AS.


Instruction: What can be avoided by appropriate treatment at the onset of even mild symptoms?

Output: More severe “classical” symptoms of AS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be avoided by appropriate treatment at the onset of even mild symptoms?. ### Response: More severe “classical” symptoms of AS.


Instruction: Outcomes after surgical or transcatheter AVR are excellent in patients who do not have a high procedural risk?

Output: LV function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Outcomes after surgical or transcatheter AVR are excellent in patients who do not have a high procedural risk?. ### Response: LV function.


Instruction: Surgical series demon-strate improved symptoms after what?

Output: AVR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Surgical series demon-strate improved symptoms after what?. ### Response: AVR.


Instruction: Most patients have an improvement in exercise toler-ance, as documented in studies with pre- and post-AVR exercise stress testing?

Output: Surgical series demon-strate improved symptoms after AVR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Most patients have an improvement in exercise toler-ance, as documented in studies with pre- and post-AVR exercise stress testing?. ### Response: Surgical series demon-strate improved symptoms after AVR.


Instruction: Historical observation studies on outcomes in symptomatic patients with severe AS have been confirmed in RCTs comparing what with palliative care?

Output: TAVI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Historical observation studies on outcomes in symptomatic patients with severe AS have been confirmed in RCTs comparing what with palliative care?. ### Response: TAVI.


Instruction: What has been confirmed in RCTs comparing TAVI with palliative care in patients with a prohibitive surgical risk?

Output: Historical observation studies on outcomes in symptomatic patients with severe AS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been confirmed in RCTs comparing TAVI with palliative care in patients with a prohibitive surgical risk?. ### Response: Historical observation studies on outcomes in symptomatic patients with severe AS.


Instruction: What is discussed in Section 3.2.4.1–3,5,6,12–16,35,42,47–552?

Output: The choice of surgical versus transcatheter AVR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is discussed in Section 3.2.4.1–3,5,6,12–16,35,42,47–552?. ### Response: The choice of surgical versus transcatheter AVR.


Instruction: What is the survival rate dur ing the asymptomatic phase similar to?

Output: that of age-matched controls

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the survival rate dur ing the asymptomatic phase similar to?. ### Response: that of age-matched controls.


Instruction: What is a low risk of sud-den death per year?

Output: (<1%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a low risk of sud-den death per year?. ### Response: (<1%.


Instruction: When patients are followed prospectively and when patients promptly report symptom onset?

Output: Clinical vigilance is needed to recognize these early symptoms and proceed promptly to AVR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When patients are followed prospectively and when patients promptly report symptom onset?. ### Response: Clinical vigilance is needed to recognize these early symptoms and proceed promptly to AVR.


Instruction: Report what?

Output: symptom onset

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Report what?. ### Response: symptom onset.


Instruction: What is the cause of depressed LVEF?

Output: excessive afterload

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cause of depressed LVEF?. ### Response: excessive afterload.


Instruction: How does LV function improve after AVR?

Output: excessive afterload

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does LV function improve after AVR?. ### Response: excessive afterload.


Instruction: What does LV function improve after AVR?

Output: depressed LVEF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does LV function improve after AVR?. ### Response: depressed LVEF.


Instruction: What is indicated for all patients in whom AVR is not yet indicated?

Output: Periodic monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is indicated for all patients in whom AVR is not yet indicated?. ### Response: Periodic monitoring.


Instruction: What type of valve type is used for patients with asymptomatic and symptomatic AS?

Output: mechanical versus bioprosthetic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of valve type is used for patients with asymptomatic and symptomatic AS?. ### Response: mechanical versus bioprosthetic.


Instruction: What is another name for Stage C and Stage D patients?

Output: asymptomatic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for Stage C and Stage D patients?. ### Response: asymptomatic.


Instruction: What type of valve type is indicated when AVR is indicated?

Output: mechanical versus bioprosthetic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of valve type is indicated when AVR is indicated?. ### Response: mechanical versus bioprosthetic.


Instruction: What does AS indicate?

Output: aortic stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does AS indicate?. ### Response: aortic stenosis.


Instruction: AVAi, aortic valve area index, what does AVR stand for?

Output: aortic valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: AVAi, aortic valve area index, what does AVR stand for?. ### Response: aortic valve replacement.


Instruction: BNP, B-type natriuretic peptide, what is BNP?

Output: BP , blood pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: BNP, B-type natriuretic peptide, what is BNP?. ### Response: BP , blood pressure.


Instruction: DSE is dobutamine stress echocardiography ETT, what is an exercise treadmill test?

Output: left ventricular ejection fraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: DSE is dobutamine stress echocardiography ETT, what is an exercise treadmill test?. ### Response: left ventricular ejection fraction.


Instruction: LVEF is left ventricular ejection fraction.

Output: ∆Pmean, mean systolic pressure gradient between LV

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: LVEF is left ventricular ejection fraction.. ### Response: ∆Pmean, mean systolic pressure gradient between LV.


Instruction: Pmean is what?

Output: mean systolic pressure gradient between LV

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Pmean is what?. ### Response: mean systolic pressure gradient between LV.


Instruction: What is the name of the study group that studied oral sodium bicarbonate therapy for older patients with chronic kidney disease and low-grade acidosis?

Output: BiCARB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study group that studied oral sodium bicarbonate therapy for older patients with chronic kidney disease and low-grade acidosis?. ### Response: BiCARB.


Instruction: What is a pragmatic randomised, double-blind, placebo-controlled trial?

Output: BiCARB study group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a pragmatic randomised, double-blind, placebo-controlled trial?. ### Response: BiCARB study group.


Instruction: What prevents glomerular filtration rate?

Output: Daily oral sodium bicarbonatepreserves glomerular ﬁltration rate by slowing its decline in earlyhypertensive nephropathy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What prevents glomerular filtration rate?. ### Response: Daily oral sodium bicarbonatepreserves glomerular ﬁltration rate by slowing its decline in earlyhypertensive nephropathy.


Instruction: What does daily oral sodium bicarbonate slow down in earlyhypertensive nephropathy?

Output: glomerular ﬁltration rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does daily oral sodium bicarbonate slow down in earlyhypertensive nephropathy?. ### Response: glomerular ﬁltration rate.


Instruction: What should maximally tolerated LDL-C lowering therapy include?

Output: maximally tolerated statin therapy and ezetimibe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should maximally tolerated LDL-C lowering therapy include?. ### Response: maximally tolerated statin therapy and ezetimibe.


Instruction: In patients with clinical ASCVD who are judged to be very high risk and considered for PCSK9 inhibitor therapy, what should include maximally tolerable statin therapy and ezetimibe?

Output: maximally tolerated LDL-C lowering therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with clinical ASCVD who are judged to be very high risk and considered for PCSK9 inhibitor therapy, what should include maximally tolerable statin therapy and ezetimibe?. ### Response: maximally tolerated LDL-C lowering therapy.


Instruction: What type of ASCVD is considered to be very high risk?

Output: clinical

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of ASCVD is considered to be very high risk?. ### Response: clinical.


Instruction: What is the maximum tolerated LDL-C lowering therapy?

Output: LDL-C 70 mg/dL or higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the maximum tolerated LDL-C lowering therapy?. ### Response: LDL-C 70 mg/dL or higher.


Instruction: How is it reasonable to add a PCSK9 inhibitor following a clinician-patient discussion?

Output: net benefit, safety, and cost

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is it reasonable to add a PCSK9 inhibitor following a clinician-patient discussion?. ### Response: net benefit, safety, and cost.


Instruction: What is a reasonable reason to add a PCSK9 inhibitor?

Output: following a clinician–patient discussion about the net benefit, safety, and cost

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a reasonable reason to add a PCSK9 inhibitor?. ### Response: following a clinician–patient discussion about the net benefit, safety, and cost.


Instruction: What is the LDL-C level of patients with ASCVD that are on statin therapy?

Output: 70 mg/dL or higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the LDL-C level of patients with ASCVD that are on statin therapy?. ### Response: 70 mg/dL or higher.


Instruction: What is the LDL-C level?

Output: low-density lipoprotein cholesterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the LDL-C level?. ### Response: low-density lipoprotein cholesterol.


Instruction: What is ezetimibe therapy reasonable for?

Output: patients with clinical ASCVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ezetimibe therapy reasonable for?. ### Response: patients with clinical ASCVD.


Instruction: How many mg of Atorvastatin does it take to reduce LDL-C?

Output: 80 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mg of Atorvastatin does it take to reduce LDL-C?. ### Response: 80 mg.


Instruction: What is the name of the primary statin medications used in clinical practice?

Output: atorvastatin, rosuvastatin, simvastatin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the primary statin medications used in clinical practice?. ### Response: atorvastatin, rosuvastatin, simvastatin.


Instruction: What were the primary statin medications used in clinical practice estimated using?

Output: median reduction in LDL-C from the VOYAGER database

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the primary statin medications used in clinical practice estimated using?. ### Response: median reduction in LDL-C from the VOYAGER database.


Instruction: What was the median reduction in LDL-C from the VOYAGER database?

Output: S3.2.1-2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the median reduction in LDL-C from the VOYAGER database?. ### Response: S3.2.1-2.


Instruction: In adults with hyperlipidemia, primary hypercholesterolemia, and mixed conditions, what were the reductions for other statin drugs identified according to?

Output: FDA-approved product labeling

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In adults with hyperlipidemia, primary hypercholesterolemia, and mixed conditions, what were the reductions for other statin drugs identified according to?. ### Response: FDA-approved product labeling.


Instruction: What does Boldface type indicate?

Output: specific statins and doses that were evaluated in RCTs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Boldface type indicate?. ### Response: specific statins and doses that were evaluated in RCTs.


Instruction: What did the Cholesterol Treatment Trialists' 2010 meta-analysis show?

Output: a reduction in major cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Cholesterol Treatment Trialists' 2010 meta-analysis show?. ### Response: a reduction in major cardiovascular events.


Instruction: What are reductions estimates from?

Output: data across large populations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are reductions estimates from?. ### Response: data across large populations.


Instruction: Individual responses to statin therapy should vary in what?

Output: RCTs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Individual responses to statin therapy should vary in what?. ### Response: RCTs.


Instruction: What should occur with the dosage listed below each intensity?

Output: LDL-C lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should occur with the dosage listed below each intensity?. ### Response: LDL-C lowering.


Instruction: What was the name of the study that evaluated simvastatin 80 mg in RCTs?

Output: IDEAL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the study that evaluated simvastatin 80 mg in RCTs?. ### Response: IDEAL.


Instruction: Why is titration to 80 mg not recommended by the FDA?

Output: increased risk of myopathy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is titration to 80 mg not recommended by the FDA?. ### Response: increased risk of myopathy.


Instruction: What does BID mean?

Output: twice daily

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does BID mean?. ### Response: twice daily.


Instruction: What does LDL-C stand for?

Output: low-density lipoprotein cholesterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does LDL-C stand for?. ### Response: low-density lipoprotein cholesterol.


Instruction: Which FDA agency is responsible for myopathy?

Output: US Food and Drug Administration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which FDA agency is responsible for myopathy?. ### Response: US Food and Drug Administration.


Instruction: What is the acronym for American College of Cardiology?

Output: ACC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for American College of Cardiology?. ### Response: ACC.


Instruction: What is ACPM?

Output: American College of Preventive Medicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ACPM?. ### Response: American College of Preventive Medicine.


Instruction: AGS stands for American Geriatrics Society.

Output: AGS, American Geriatrics Society

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: AGS stands for American Geriatrics Society.. ### Response: AGS, American Geriatrics Society.


Instruction: AHA stands for what?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: AHA stands for what?. ### Response: American Heart Association.


Instruction: What is the acronym for the National Lipid Association?

Output: NLA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the National Lipid Association?. ### Response: NLA.


Instruction: What does NLA stand for?

Output: National Lipid Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does NLA stand for?. ### Response: National Lipid Association.


Instruction: How does PCNA stand for preventive cardiovascular nurses?

Output: Preventive Cardiovascular Nurses Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does PCNA stand for preventive cardiovascular nurses?. ### Response: Preventive Cardiovascular Nurses Association.


Instruction: When was COR LOE published?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was COR LOE published?. ### Response: April 28, 2023.


Instruction: What percentage of untreated isolated distal DVT are expected to subsequently extend into the popliteal vein and may cause PE?

Output: 15%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of untreated isolated distal DVT are expected to subsequently extend into the popliteal vein and may cause PE?. ### Response: 15%.


Instruction: What is not acceptable to neither anticoagulate nordo surveillance to detect thrombus extension?

Output: about 15% of untreated isolated distal DVT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not acceptable to neither anticoagulate nordo surveillance to detect thrombus extension?. ### Response: about 15% of untreated isolated distal DVT.


Instruction: Anticoagulate nordo surveillance to detect thrombus extension?

Output: surveillance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Anticoagulate nordo surveillance to detect thrombus extension?. ### Response: surveillance.


Instruction: In AT9, what was effective for thetreatment of proximal DVT and PE?

Output: anticoagulant therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In AT9, what was effective for thetreatment of proximal DVT and PE?. ### Response: anticoagulant therapy.


Instruction: Why did patients with isolated distal DVT have lower risk of progressive or recurrent VTE?

Output: uncertainty thatthe bene ﬁts of anticoagulation outweigh its risks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why did patients with isolated distal DVT have lower risk of progressive or recurrent VTE?. ### Response: uncertainty thatthe bene ﬁts of anticoagulation outweigh its risks.


Instruction: Why do people with DVT have a lower risk of progressive or recurrent VTE?

Output: inpatients with isolated distal DVT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why do people with DVT have a lower risk of progressive or recurrent VTE?. ### Response: inpatients with isolated distal DVT.


Instruction: What would favor anticoagulation over surveillance?

Output: risk factors for extension of distal DVT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would favor anticoagulation over surveillance?. ### Response: risk factors for extension of distal DVT.


Instruction: How long is thrombosis?

Output: >5 cm in length

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is thrombosis?. ### Response: >5 cm in length.


Instruction: What is thrombosis con fined to the muscular veins of thecalf?

Output: lower risk ofextension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is thrombosis con fined to the muscular veins of thecalf?. ### Response: lower risk ofextension.


Instruction: What is there no reversibleprovoking factor for?

Output: DVT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is there no reversibleprovoking factor for?. ### Response: DVT.


Instruction: What veins are fined to the muscular veins of thecalf to have a lower risk oftension than thrombosis that involves the axial(ie, true deep; peroneal, tibial) veins?

Output: thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What veins are fined to the muscular veins of thecalf to have a lower risk oftension than thrombosis that involves the axial(ie, true deep; peroneal, tibial) veins?. ### Response: thrombosis.


Instruction: What type ofsymptoms favor anticoagulation?

Output: Severes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type ofsymptoms favor anticoagulation?. ### Response: Severes.


Instruction: A high risk for bleeding favors what type of surveillance?

Output: serial imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A high risk for bleeding favors what type of surveillance?. ### Response: serial imaging.


Instruction: What is expected to be sensitive to patient preferences?

Output: agulation or surveillance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is expected to be sensitive to patient preferences?. ### Response: agulation or surveillance.


Instruction: DistalDVT that are detected using a selective approach towhole-leg US will often satisfy criteria for initialanticoagulation?

Output: surveillance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: DistalDVT that are detected using a selective approach towhole-leg US will often satisfy criteria for initialanticoagulation?. ### Response: surveillance.


Instruction: What did not identify any newrandomized trials?

Output: The updated literature search

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did not identify any newrandomized trials?. ### Response: The updated literature search.


Instruction: Did the updated literature search identify any new randomized trials that assessed management of patients with isolated distal DVT?

Output: did not

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Did the updated literature search identify any new randomized trials that assessed management of patients with isolated distal DVT?. ### Response: did not.


Instruction: What did two new systematic reviews76,77and a narrative review83address?

Output: treatment of isolated distal DV

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did two new systematic reviews76,77and a narrative review83address?. ### Response: treatment of isolated distal DV.


Instruction: In addition to summarizing available data, what did they emphasize?

Output: the limitations of available evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In addition to summarizing available data, what did they emphasize?. ### Response: the limitations of available evidence.


Instruction: The panel endorsed the AT9 recommendations without what?

Output: revision

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The panel endorsed the AT9 recommendations without what?. ### Response: revision.


Instruction: What is the ability to predict in patients with acute isolated distal DVT limited?

Output: ension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ability to predict in patients with acute isolated distal DVT limited?. ### Response: ension.


Instruction: What is limited in patients with acute isolated distal DVT of the leg?

Output: ability to predictextension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is limited in patients with acute isolated distal DVT of the leg?. ### Response: ability to predictextension.


Instruction: How long do we suggest serial imaging of thedeep veins?

Output: 2 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long do we suggest serial imaging of thedeep veins?. ### Response: 2 weeks.


Instruction: What is grade 2C?

Output: anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is grade 2C?. ### Response: anticoagulation.


Instruction: Patients at high risk for bleeding are more likely to bene fit from what?

Output: serial imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients at high risk for bleeding are more likely to bene fit from what?. ### Response: serial imaging.


Instruction: What was the overall aim of the project?

Output: to develop an evidence-based CPG for the use of BP-lowering agents in individualswith CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the overall aim of the project?. ### Response: to develop an evidence-based CPG for the use of BP-lowering agents in individualswith CKD.


Instruction: What did the guideline consist of recommendationstatements, rationale, and?

Output: a summary of systematicallygenerated evidence on relevant pre-deﬁned clinical topics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the guideline consist of recommendationstatements, rationale, and?. ### Response: a summary of systematicallygenerated evidence on relevant pre-deﬁned clinical topics.


Instruction: What did the KDIGO Clinical PracticeGuideline for the Management of Blood Pressure in Chronic Kidney Disease include?

Output: the following steps

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the KDIGO Clinical PracticeGuideline for the Management of Blood Pressure in Chronic Kidney Disease include?. ### Response: the following steps.


Instruction: What steps were included in the development process for the Clinical Practice Guideline?

Output: KAppointing Work Group members and the ERT.K

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What steps were included in the development process for the Clinical Practice Guideline?. ### Response: KAppointing Work Group members and the ERT.K.


Instruction: Who was appointed as Work Group members and the ERT?

Output: Work Group Co-Chairs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was appointed as Work Group members and the ERT?. ### Response: Work Group Co-Chairs.


Instruction: What is a key part of identifying populations, interventions or predictors?

Output: outcomes of interest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a key part of identifying populations, interventions or predictors?. ### Response: outcomes of interest.


Instruction: What is another part of the process of selecting topics for systematic evidence review?

Output: topic discussion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another part of the process of selecting topics for systematic evidence review?. ### Response: topic discussion.


Instruction: What does KGrading the methodology and outcomes in individualstudies do?

Output: Tabulating data from individual studies into summarytables

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does KGrading the methodology and outcomes in individualstudies do?. ### Response: Tabulating data from individual studies into summarytables.


Instruction: What is KTabulating data from individual studies into?

Output: summarytables

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is KTabulating data from individual studies into?. ### Response: summarytables.


Instruction: How is the quality of evidence for each outcome assessed?

Output: evidence profiles

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the quality of evidence for each outcome assessed?. ### Response: evidence profiles.


Instruction: How long did the Work Group, ERT, and KDIGOsupport staff meet for?

Output: three 2-day meetings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the Work Group, ERT, and KDIGOsupport staff meet for?. ### Response: three 2-day meetings.


Instruction: When was the draft of the guideline sent for peer review to the KDIGOBoard of Directors?

Output: December 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the draft of the guideline sent for peer review to the KDIGOBoard of Directors?. ### Response: December 2010.


Instruction: How many days did the group, ERT, and KDIGOsupport staff meet for?

Output: three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many days did the group, ERT, and KDIGOsupport staff meet for?. ### Response: three.


Instruction: What was the purpose of the three 2-day meetings?

Output: training

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the purpose of the three 2-day meetings?. ### Response: training.


Instruction: Who appointed the Work Group Co-Chairs?

Output: KDIGO Co-Chairs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who appointed the Work Group Co-Chairs?. ### Response: KDIGO Co-Chairs.


Instruction: Where is the Tufts Center for Kidney Disease GuidelineDevelopment and Implementation located?

Output: Boston, Massachusetts, USA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the Tufts Center for Kidney Disease GuidelineDevelopment and Implementation located?. ### Response: Boston, Massachusetts, USA.


Instruction: What did the ERT instruct and advise WorkGroup members in all steps of literature review, criticalliterature appraisal, and guideline development?

Output: The ERTconsisted of physician–methodologists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the ERT instruct and advise WorkGroup members in all steps of literature review, criticalliterature appraisal, and guideline development?. ### Response: The ERTconsisted of physician–methodologists.


Instruction: How did the WorkGroup and ERT collaborate throughout the project?

Output: closely

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did the WorkGroup and ERT collaborate throughout the project?. ### Response: closely.


Instruction: What has been largely unsuccessful in improving symptoms of claudication or walking dis-tance in patients with PAD?

Output: Hypertension  June 2015blockers, and direct vasodilators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been largely unsuccessful in improving symptoms of claudication or walking dis-tance in patients with PAD?. ### Response: Hypertension  June 2015blockers, and direct vasodilators.


Instruction: What do -blockers constrict resistance vessels?

Output: β-blockers constrict resistance vessels, a meta-analysis concluded that this drug class does not worsen intermittent claudication

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do -blockers constrict resistance vessels?. ### Response: β-blockers constrict resistance vessels, a meta-analysis concluded that this drug class does not worsen intermittent claudication.


Instruction: What can be used in PAD patients with compelling indications for their use such as CAD or HF?

Output: β-blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be used in PAD patients with compelling indications for their use such as CAD or HF?. ### Response: β-blockers.


Instruction: What should be administered to hyperten-sive patients with lower-extremity PAD?

Output: Antihypertensive therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be administered to hyperten-sive patients with lower-extremity PAD?. ### Response: Antihypertensive therapy.


Instruction: What should be given to hypertensive patients with lower-extremity PAD to achieve a goal of 140/90 mm Hg (nondiabetics)?

Output: Antihypertensive therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be given to hypertensive patients with lower-extremity PAD to achieve a goal of 140/90 mm Hg (nondiabetics)?. ### Response: Antihypertensive therapy.


Instruction: What should therapy be administered to to reduce the risk of MI, stroke, congestive HF, and cardiovascular death?

Output: Antihypertensive therapy should be administered to hyperten-sive patients with lower-extremity PAD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should therapy be administered to to reduce the risk of MI, stroke, congestive HF, and cardiovascular death?. ### Response: Antihypertensive therapy should be administered to hyperten-sive patients with lower-extremity PAD.


Instruction: What is a Level of Evidence A?

Output: Antihypertensive therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a Level of Evidence A?. ### Response: Antihypertensive therapy.


Instruction: What are effective antihypertensive agents?

Output: β-adrenergic blocking drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are effective antihypertensive agents?. ### Response: β-adrenergic blocking drugs.


Instruction: What is CKD defined as?

Output: kidney damage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CKD defined as?. ### Response: kidney damage.


Instruction: How long has there been a steady increase in the prevalence of?

Output: ≥ 3 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long has there been a steady increase in the prevalence of?. ### Response: ≥ 3 months.


Instruction: What is the glomerular filtration rate to?

Output: <60 mL· min−1·1.73 m−2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the glomerular filtration rate to?. ### Response: <60 mL· min−1·1.73 m−2.


Instruction: What is the glomerular filtration rate for 3 months?

Output: <60 mL· min−1·1.73 m−2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the glomerular filtration rate for 3 months?. ### Response: <60 mL· min−1·1.73 m−2.


Instruction: What is kidney failure defined as?

Output: a glomer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is kidney failure defined as?. ### Response: a glomer.


Instruction: How many patients in the US are affected by kidney failure?

Output: >525 000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients in the US are affected by kidney failure?. ### Response: >525 000.


Instruction: How many people in the US are on long-term hemodialysis?

Output: 65%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people in the US are on long-term hemodialysis?. ### Response: 65%.


Instruction: What is the preva-lence of hypertension in hypertensive patients?

Output: 28%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the preva-lence of hypertension in hypertensive patients?. ### Response: 28%.


Instruction: Cardiovascular death is more likely than what in patients with CKD?

Output: progression to end-stage renal disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cardiovascular death is more likely than what in patients with CKD?. ### Response: progression to end-stage renal disease.


Instruction: What is the leading cause of death in patients with end-stage renal dis-ease?

Output: CVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the leading cause of death in patients with end-stage renal dis-ease?. ### Response: CVD.


Instruction: How many times higher is CVD in patients on dialysis than in the general population?

Output: 5 to 30

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many times higher is CVD in patients on dialysis than in the general population?. ### Response: 5 to 30.


Instruction: In patients with lower stages of CKD, the risk of CVD is what?

Output: increased independently of other risk factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with lower stages of CKD, the risk of CVD is what?. ### Response: increased independently of other risk factors.


Instruction: What is a leading cause of renal failure?

Output: hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a leading cause of renal failure?. ### Response: hypertension.


Instruction: What is the risk of CVD and all-cause death increased by even the smallest degree of?

Output: albuminuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of CVD and all-cause death increased by even the smallest degree of?. ### Response: albuminuria.


Instruction: What are the BP goals in patients with CKD and microalbuminuria lower than in the general popula-tion?

Output: target the same as that in patients with estab-lished CAD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the BP goals in patients with CKD and microalbuminuria lower than in the general popula-tion?. ### Response: target the same as that in patients with estab-lished CAD.


Instruction: What is a target the same as in estab-lished CAD?

Output: BP goals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a target the same as in estab-lished CAD?. ### Response: BP goals.


Instruction: Recent investigations have shown that standard treatments for cardiovascular risk factors are what?

Output: statin therapy, ACE inhibitors, ARBs, and antiplatelet agents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Recent investigations have shown that standard treatments for cardiovascular risk factors are what?. ### Response: statin therapy, ACE inhibitors, ARBs, and antiplatelet agents.


Instruction: What are statins, ACE inhibitors, ARBs, and antiplatelet agents equally effective at in patients with CKD?

Output: risk reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are statins, ACE inhibitors, ARBs, and antiplatelet agents equally effective at in patients with CKD?. ### Response: risk reduction.


Instruction: What is another term for patients who are not on dialysis?

Output: CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for patients who are not on dialysis?. ### Response: CKD.


Instruction: Who published the 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary?

Output: Arnett et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary?. ### Response: Arnett et al.


Instruction: What is the name of the guideline published by the American College of Cardiology?

Output: Guideline on the Primary Prevention of Cardiovascular Disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the guideline published by the American College of Cardiology?. ### Response: Guideline on the Primary Prevention of Cardiovascular Disease.


Instruction: What is an effect modifier in chronic kidney disease?

Output: proteinuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an effect modifier in chronic kidney disease?. ### Response: proteinuria.


Instruction: What is the role of blood pressure control, proteinuria, and inhibition of angio-tensin-converting enzyme?

Output: Progression of chronic kidney disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of blood pressure control, proteinuria, and inhibition of angio-tensin-converting enzyme?. ### Response: Progression of chronic kidney disease.


Instruction: What is a patient-level meta-analysis?

Output: Progression of chronic kidney disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a patient-level meta-analysis?. ### Response: Progression of chronic kidney disease.


Instruction: What is an effect of intensive blood pressure lowering on the progression of chronic kidney disease?

Output: proteinuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an effect of intensive blood pressure lowering on the progression of chronic kidney disease?. ### Response: proteinuria.


Instruction: What are the effects of dietary protein restriction and blood-pressure control on the progression of chronic renal disease?

Output: 4.4-48

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the effects of dietary protein restriction and blood-pressure control on the progression of chronic renal disease?. ### Response: 4.4-48.


Instruction: What is the name of the group that modifies the diet in renal disease study group?

Output: Klahr S, Levey AS, Beck GJ, et al. The effects of dietary protein restriction and blood-pressure control on the progression of chronic renal disease. Modification of Diet in Renal Disease Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that modifies the diet in renal disease study group?. ### Response: Klahr S, Levey AS, Beck GJ, et al. The effects of dietary protein restriction and blood-pressure control on the progression of chronic renal disease. Modification of Diet in Renal Disease Study Group.


Instruction: When was the N Engl J Med 330:877-84 published?

Output: 1994

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the N Engl J Med 330:877-84 published?. ### Response: 1994.


Instruction: What is the name of the systematic review and meta-analysis of blood pressure lowering in type 2 diabetes?

Output: Emdin CA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta-analysis of blood pressure lowering in type 2 diabetes?. ### Response: Emdin CA.


Instruction: When did Arguedas JA, Leiva V, Wright JM, write their paper?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Arguedas JA, Leiva V, Wright JM, write their paper?. ### Response: 2015.


Instruction: What did the Cochrane Database Syst Rev do in 2013?

Output: CD008277

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Cochrane Database Syst Rev do in 2013?. ### Response: CD008277.


Instruction: What is the name of the randomized trial in which com-bined cardiovascular risk factor management strategies were used?

Output: ACCORD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized trial in which com-bined cardiovascular risk factor management strategies were used?. ### Response: ACCORD.


Instruction: What was the number of participants in the ACCORD trial in type 2 diabetes?

Output: S4.4-52

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the number of participants in the ACCORD trial in type 2 diabetes?. ### Response: S4.4-52.


Instruction: Which type of control did Bress AP and Bellows BK prefer?

Output: standard blood-pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which type of control did Bress AP and Bellows BK prefer?. ### Response: standard blood-pressure.


Instruction: What is the difference between inten-sive and standard blood pressure control?

Output: Cost-effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between inten-sive and standard blood pressure control?. ### Response: Cost-effectiveness.


Instruction: What are the results of the action to control cardiovascular risk in diabetes blood pressure trial?

Output: Effect of intensive blood pressure lowering on left ventricular hypertrophy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of the action to control cardiovascular risk in diabetes blood pressure trial?. ### Response: Effect of intensive blood pressure lowering on left ventricular hypertrophy.


Instruction: When did the Action to Control Cardiovascular Risk in Diabetes trial take place?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Action to Control Cardiovascular Risk in Diabetes trial take place?. ### Response: 2014.


Instruction: What is the risk in Diabetes blood pressure trial?

Output: Action to Control Cardiovascular Risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk in Diabetes blood pressure trial?. ### Response: Action to Control Cardiovascular Risk.


Instruction: What are the outcomes of intensive blood pressure control in type 2 diabetes mellitus?

Output: cardiovascular outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the outcomes of intensive blood pressure control in type 2 diabetes mellitus?. ### Response: cardiovascular outcomes.


Instruction: What is the age-specific relevance of usual blood pressure to vascular mortality?

Output: a meta-analysis of indi-vidual data for one million adults in 61 prospective studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the age-specific relevance of usual blood pressure to vascular mortality?. ### Response: a meta-analysis of indi-vidual data for one million adults in 61 prospective studies.


Instruction: How many prospective studies did the meta-analysis of indi-vidual data for one million adults in?

Output: 61

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many prospective studies did the meta-analysis of indi-vidual data for one million adults in?. ### Response: 61.


Instruction: When did the Lancet issue 360:1903-13?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Lancet issue 360:1903-13?. ### Response: 2002.


Instruction: What did Kassa B, Boissel J-P, Cucherat M, et al. treat?

Output: high blood pres-sure and gain in event-free life expectancy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Kassa B, Boissel J-P, Cucherat M, et al. treat?. ### Response: high blood pres-sure and gain in event-free life expectancy.