Instruction: Intracranial aneurysms are a feature of certain mendelian disorders?

Output: cerebral venous thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Intracranial aneurysms are a feature of certain mendelian disorders?. ### Response: cerebral venous thrombosis.


Instruction: What is Ehlers-Danlos type IV syndrome?

Output: vas-cular Ehlers-Danlos

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Ehlers-Danlos type IV syndrome?. ### Response: vas-cular Ehlers-Danlos.


Instruction: What percentage of individuals with autosomal-dominant polycystic kidney disease have cervical fibromuscular dysplasia?

Output: 7%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of individuals with autosomal-dominant polycystic kidney disease have cervical fibromuscular dysplasia?. ### Response: 7%.


Instruction: What type of mutations in KRIT1 cause cerebral cavernous malformation syn-dromes CCM1, CCM2, and CCM3?

Output: Loss-of-function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of mutations in KRIT1 cause cerebral cavernous malformation syn-dromes CCM1, CCM2, and CCM3?. ### Response: Loss-of-function.


Instruction: What are the malformation syn-dromes CCM1, CCM2, and CCM3?

Output: cerebral cavernous

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the malformation syn-dromes CCM1, CCM2, and CCM3?. ### Response: cerebral cavernous.


Instruction: Mutations in what gene can cause inherited cerebral amyloid angiopathy syndromes?

Output: amyloid precursor protein gene

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Mutations in what gene can cause inherited cerebral amyloid angiopathy syndromes?. ### Response: amyloid precursor protein gene.


Instruction: What has been considered appropriately when formulating our revas-cularization recommendations?

Output: the results of SYNTAX

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been considered appropriately when formulating our revas-cularization recommendations?. ### Response: the results of SYNTAX.


Instruction: What is areasonable surrogate for the extent of CAD and its complexity?

Output: Calculation of the Society of Thoracic Surgeons(STS) and SYNTAX scores

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is areasonable surrogate for the extent of CAD and its complexity?. ### Response: Calculation of the Society of Thoracic Surgeons(STS) and SYNTAX scores.


Instruction: What should be considered when making revascularization decisions?

Output: SYNTAX score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered when making revascularization decisions?. ### Response: SYNTAX score.


Instruction: What are SYNTAX scores used assurrogates for the extent and complexity of?

Output: CAD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are SYNTAX scores used assurrogates for the extent and complexity of?. ### Response: CAD.


Instruction: What aresummarized in Tables 2 and 3?

Output: Revascularization recommendations to improve survivaland symptoms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What aresummarized in Tables 2 and 3?. ### Response: Revascularization recommendations to improve survivaland symptoms.


Instruction: What is presented in Table 2 and3?

Output: Revascularization recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is presented in Table 2 and3?. ### Response: Revascularization recommendations.


Instruction: What is recommended in patients with unprotected left main or complex CAD?

Output: A Heart Team approach to revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended in patients with unprotected left main or complex CAD?. ### Response: A Heart Team approach to revascularization.


Instruction: What is the level of evidence for STS and SYNTAX scores?

Output: B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the level of evidence for STS and SYNTAX scores?. ### Response: B.


Instruction: What is a multidisciplinary approach used in RCTs14-16?

Output: Heart Team

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a multidisciplinary approach used in RCTs14-16?. ### Response: Heart Team.


Instruction: What is the Heart Team composed of?

Output: an interventional cardiologist and a cardiac surgeon

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Heart Team composed of?. ### Response: an interventional cardiologist and a cardiac surgeon.


Instruction: The Heart Team reviews the patient’s medical condition and what else?

Output: coronary anatomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The Heart Team reviews the patient’s medical condition and what else?. ### Response: coronary anatomy.


Instruction: What type of approach is supported by reports of patients with complex CAD referred for PCI or CABG in concurrently?

Output: Heart Team

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of approach is supported by reports of patients with complex CAD referred for PCI or CABG in concurrently?. ### Response: Heart Team.


Instruction: Who determines that PCI and/or CABG are feasible and reasonable?

Output: theHeart Team

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who determines that PCI and/or CABG are feasible and reasonable?. ### Response: theHeart Team.


Instruction: Whose mortality rates are lower with complexCAD referred specifically for PCI or CABG in concurrent trial registries?

Output: patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Whose mortality rates are lower with complexCAD referred specifically for PCI or CABG in concurrent trial registries?. ### Response: patients.


Instruction: What are the SIHD, PCI and CABG guideline writing committees responsible for?

Output: survival and symptomatic benefits

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the SIHD, PCI and CABG guideline writing committees responsible for?. ### Response: survival and symptomatic benefits.


Instruction: What does recanalization of acute bas-ilar artery occlusion improve?

Output: outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does recanalization of acute bas-ilar artery occlusion improve?. ### Response: outcomes.


Instruction: What is a meta-analysis of prospective randomized controlled trials evaluating endovascular therapies for?

Output: acute ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a meta-analysis of prospective randomized controlled trials evaluating endovascular therapies for?. ### Response: acute ischemic stroke.


Instruction: What is the name of the meta-analysis that shows that stent retrievers improve outcomes?

Output: Cochrane Database

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis that shows that stent retrievers improve outcomes?. ### Response: Cochrane Database.


Instruction: When was the J Neurointerv Surg published?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Neurointerv Surg published?. ### Response: 2011.


Instruction: What is a comprehensive review and meta-analysis for the management of acute ischemic stroke?

Output: Safety and efficacy of stent retrievers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a comprehensive review and meta-analysis for the management of acute ischemic stroke?. ### Response: Safety and efficacy of stent retrievers.


Instruction: What is the name of the systematic review of endovascular thrombectomy for anterior circulation stroke? What is one of the main findings of the review?

Output: meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review of endovascular thrombectomy for anterior circulation stroke? What is one of the main findings of the review?. ### Response: meta-analysis.


Instruction: How many strokes are there in 2015?

Output: 462

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes are there in 2015?. ### Response: 462.


Instruction: What is the name of the device used in stroke therapy?

Output: Merci

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the device used in stroke therapy?. ### Response: Merci.


Instruction: What system was used in the stroke therapy study?

Output: argatroban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What system was used in the stroke therapy study?. ### Response: argatroban.


Instruction: How many strokes were treated with the Merci device?

Output: 2015.07.021 462

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes were treated with the Merci device?. ### Response: 2015.07.021 462.


Instruction: What is the name of the meta-analysis of randomized intra-arterial thrombolytic trials for the treatment of acute stroke due to middle ce-rebral artery occlusion?

Output: STROKEAHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis of randomized intra-arterial thrombolytic trials for the treatment of acute stroke due to middle ce-rebral artery occlusion?. ### Response: STROKEAHA.


Instruction: When did JD, Khatri P, Nesbit GM, Liu KC, Barnwell SL, Lutsep HL, Lansberg MG, and Clark WM do?

Output: Fields

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did JD, Khatri P, Nesbit GM, Liu KC, Barnwell SL, Lutsep HL, Lansberg MG, and Clark WM do?. ### Response: Fields.


Instruction: What is the difference between general anesthesia and conscious sedation for endovascular treatment of acute ischemic stroke?

Output: AnStroke trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between general anesthesia and conscious sedation for endovascular treatment of acute ischemic stroke?. ### Response: AnStroke trial.


Instruction: What does the AnStroke trial stand for?

Output: Anesthesia During Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the AnStroke trial stand for?. ### Response: Anesthesia During Stroke.


Instruction: What is the name of the 2017 issue of Stroke?

Output: STROKEAHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2017 issue of Stroke?. ### Response: STROKEAHA.


Instruction: How many strokes were there between 2016 and 2017?

Output: 471–476. doi: 10.1161/STROKEAHA.115.011250 468

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes were there between 2016 and 2017?. ### Response: 471–476. doi: 10.1161/STROKEAHA.115.011250 468.


Instruction: What was the main difference between 2017 and 2017 in terms of stroke treatment?

Output: Conscious sedation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the main difference between 2017 and 2017 in terms of stroke treatment?. ### Response: Conscious sedation.


Instruction: What is the name of the study conducted in Japan?

Output: Outcomes of argatroban treatment in patients with atherothrombotic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study conducted in Japan?. ### Response: Outcomes of argatroban treatment in patients with atherothrombotic stroke.


Instruction: What is one of the outcomes of argatroban treatment in stroke patients?

Output: General anesthesia versus conscious sedation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the outcomes of argatroban treatment in stroke patients?. ### Response: General anesthesia versus conscious sedation.


Instruction: What is the Cochrane Database Syst Rev. 2008:CD000024. 469?

Output: Anticoagulants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Cochrane Database Syst Rev. 2008:CD000024. 469?. ### Response: Anticoagulants.


Instruction: What is low-molecular-weight heparin and early neurologic deteri-oration in acute stroke caused by large artery occlusive disease?

Output: Low-molecular-weight heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is low-molecular-weight heparin and early neurologic deteri-oration in acute stroke caused by large artery occlusive disease?. ### Response: Low-molecular-weight heparin.


Instruction: What disease is caused by large artery occlusive disease?

Output: Low-molecular-weight heparin and early neurologic deteri-oration in acute stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What disease is caused by large artery occlusive disease?. ### Response: Low-molecular-weight heparin and early neurologic deteri-oration in acute stroke.


Instruction: What is the name of the 2012 issue of Arch Neurol?

Output: 2012.1633 470

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2012 issue of Arch Neurol?. ### Response: 2012.1633 470.


Instruction: What is the name of the 2019 ACC/AHA guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary?

Output: Arnett

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2019 ACC/AHA guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary?. ### Response: Arnett.


Instruction: How long is the time horizon to the clinical mani-festation of disease?

Output: —many decades in the young

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the time horizon to the clinical mani-festation of disease?. ### Response: —many decades in the young.


Instruction: How many decades in the young is it difficult to assess long-term effectiveness?

Output: —many decades

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many decades in the young is it difficult to assess long-term effectiveness?. ### Response: —many decades.


Instruction: What is QALYs?

Output: quality-adjusted life-years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is QALYs?. ### Response: quality-adjusted life-years.


Instruction: What are QALYs?

Output: quality-adjusted life-years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are QALYs?. ### Response: quality-adjusted life-years.


Instruction: What is the principle that places relative emphasis on current costs and benefits while deemphasizing downstream cost and benefits?

Output: discounting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the principle that places relative emphasis on current costs and benefits while deemphasizing downstream cost and benefits?. ### Response: discounting.


Instruction: What are disadvantages for prevention because costs of-ten accrue in the present while the benefit may only be fully realized long into the future?

Output: the principle of discounting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are disadvantages for prevention because costs of-ten accrue in the present while the benefit may only be fully realized long into the future?. ### Response: the principle of discounting.


Instruction: Prior AHA statements have highlighted what?

Output: public policies, community efforts, and pharmacological interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Prior AHA statements have highlighted what?. ### Response: public policies, community efforts, and pharmacological interventions.


Instruction: What are likely to be cost-effective and at times cost-saving prevention tac-tics compared with common benchmarks?

Output: public policies, community efforts, and pharmacological interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are likely to be cost-effective and at times cost-saving prevention tac-tics compared with common benchmarks?. ### Response: public policies, community efforts, and pharmacological interventions.


Instruction: Antihypertensive therapyS5-3-S5-6 and statin therapyS5-7-S5,-9 particularly with low-cost generic drug formulations are high-value inter ventions across a wide spectrum of risk and age strata?

Output: high

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Antihypertensive therapyS5-3-S5-6 and statin therapyS5-7-S5,-9 particularly with low-cost generic drug formulations are high-value inter ventions across a wide spectrum of risk and age strata?. ### Response: high.


Instruction: What is one of several considerations in medical decision-making and resource allocation?

Output: The incorporation of the value category into clinical practice guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of several considerations in medical decision-making and resource allocation?. ### Response: The incorporation of the value category into clinical practice guidelines.


Instruction: What must clini-cians, researchers, and policymakers place in the proper context?

Output: cost-effective analyses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must clini-cians, researchers, and policymakers place in the proper context?. ### Response: cost-effective analyses.


Instruction: What is needed to fully characterize the full spectrum of benefits produced by the preven-tion approach?

Output: Further research and methodological advances

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed to fully characterize the full spectrum of benefits produced by the preven-tion approach?. ### Response: Further research and methodological advances.


Instruction: What is more consequential to cost-effectiveness as-sessments?

Output: uncertainty about outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more consequential to cost-effectiveness as-sessments?. ### Response: uncertainty about outcome.


Instruction: What does the preven-tion approach make more consequential to clinical practice?

Output: cost-effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the preven-tion approach make more consequential to clinical practice?. ### Response: cost-effectiveness.


Instruction: Most ASCVD events are avoidable through what?

Output: primordial prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Most ASCVD events are avoidable through what?. ### Response: primordial prevention.


Instruction: Tobacco avoidance is critically important for what kind of prevention?

Output: ASCVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Tobacco avoidance is critically important for what kind of prevention?. ### Response: ASCVD.


Instruction: What should all adults strive to do most days of the Table 8?

Output: regular brisk physical activity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should all adults strive to do most days of the Table 8?. ### Response: regular brisk physical activity.


Instruction: What are the highlights of Recommended Behavioral and Pharmacotherapy Tobacco Treatment Modalities?

Output: *Timing of Behavioral Interventions†<3 min of tobacco status assessment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the highlights of Recommended Behavioral and Pharmacotherapy Tobacco Treatment Modalities?. ### Response: *Timing of Behavioral Interventions†<3 min of tobacco status assessment.


Instruction: What is the utility of repeat stress testing in patients with known CAD?

Output: 6.3.6. Utility of Repeat Stress Testing in Patients WithKnown CADThe interpretation of repeat testing should be based on athreshold change value that exceeds the expected variabilityin test results

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the utility of repeat stress testing in patients with known CAD?. ### Response: 6.3.6. Utility of Repeat Stress Testing in Patients WithKnown CADThe interpretation of repeat testing should be based on athreshold change value that exceeds the expected variabilityin test results.


Instruction: What should be based on athreshold change value that exceeds the expected variability?

Output: The interpretation of repeat testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be based on athreshold change value that exceeds the expected variability?. ### Response: The interpretation of repeat testing.


Instruction: What is not well established about the variability of exercise and stresstesting results?

Output: differences in day-to-day operations in the same laboratory

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not well established about the variability of exercise and stresstesting results?. ### Response: differences in day-to-day operations in the same laboratory.


Instruction: How many factors are important contributors to observed differences in serial testing?

Output: 306,1251

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many factors are important contributors to observed differences in serial testing?. ### Response: 306,1251.


Instruction: A 5% change in the percent of ischemic myocardium is what?

Output: based on extent andseverity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A 5% change in the percent of ischemic myocardium is what?. ### Response: based on extent andseverity.


Instruction: How much change in the percent of ischemic myocardium has been suggested by some investigators as athreshold that indicates clinical significant change for stressnuclear MPI?

Output: 5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much change in the percent of ischemic myocardium has been suggested by some investigators as athreshold that indicates clinical significant change for stressnuclear MPI?. ### Response: 5%.


Instruction: What can be even more difficult to compare the findings from different exercise or stress imagingmodalities?

Output: echocardiography versus nuclearMPI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be even more difficult to compare the findings from different exercise or stress imagingmodalities?. ### Response: echocardiography versus nuclearMPI.


Instruction: NuclearMPI) can be even more difficult to compare what?

Output: different exercise orstress imaging modalities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: NuclearMPI) can be even more difficult to compare what?. ### Response: different exercise orstress imaging modalities.


Instruction: What shouldclinicians use the same imaging modality over time whenever possible?

Output: different exercise orstress imaging modalities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What shouldclinicians use the same imaging modality over time whenever possible?. ### Response: different exercise orstress imaging modalities.


Instruction: How can interval change in repeat testing alter risk assessment?

Output: the presenceof significant interval change

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can interval change in repeat testing alter risk assessment?. ### Response: the presenceof significant interval change.


Instruction: How long of randomized treatment did patients who exercise nuclear MPI normalize after 6 months have an improved survival?

Output: 6months of randomized treatment had an improved survivalFigure 15

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long of randomized treatment did patients who exercise nuclear MPI normalize after 6 months have an improved survival?. ### Response: 6months of randomized treatment had an improved survivalFigure 15.


Instruction: What does MPI stand for?

Output: myocardialperfusion imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does MPI stand for?. ### Response: myocardialperfusion imaging.


Instruction: When was the full text of Fihn et al Stable Ischemic Heart Disease published?

Output: May 1, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the full text of Fihn et al Stable Ischemic Heart Disease published?. ### Response: May 1, 2023.


Instruction: What is the International SocietyonHypertensioninBlacksconsensusstatement?

Output: ManagementofhighbloodpressureinBlacks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the International SocietyonHypertensioninBlacksconsensusstatement?. ### Response: ManagementofhighbloodpressureinBlacks.


Instruction: What are the next steps indevelopingclinicalpracticeguidelinesforprevention?

Output: 43

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the next steps indevelopingclinicalpracticeguidelinesforprevention?. ### Response: 43.


Instruction: Who published the 2014GuidelineforManagementofHigh Blood PressureE14?

Output: JAMA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2014GuidelineforManagementofHigh Blood PressureE14?. ### Response: JAMA.


Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020 Page 121 of 127 46?

Output: Newman CB, Preiss D, Tobert JA, et al .

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020 Page 121 of 127 46?. ### Response: Newman CB, Preiss D, Tobert JA, et al ..


Instruction: What is a scientific statement from the American Heart Association?

Output: Statin safety and associated adverse events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a scientific statement from the American Heart Association?. ### Response: Statin safety and associated adverse events.


Instruction: What is Rosuvastatin to prevent in men and women with elevated C -reactive protein?

Output: vascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Rosuvastatin to prevent in men and women with elevated C -reactive protein?. ### Response: vascular events.


Instruction: What is the name of the study that aimed to prevent vascular events?

Output: Rosuvastatin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that aimed to prevent vascular events?. ### Response: Rosuvastatin.


Instruction: What did Engl J Med. Nov 20 2008:359(21):2195 -2207?

Output: C -reactive protein

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Engl J Med. Nov 20 2008:359(21):2195 -2207?. ### Response: C -reactive protein.


Instruction: What did Engeda JC, Stackhouse A, White M, et al. Evidence of heterogeneity in statin-associated type 2 diabetes mellitus risk: A meta-analysis of randomized controlled trials and observational studies?

Output: 48

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Engeda JC, Stackhouse A, White M, et al. Evidence of heterogeneity in statin-associated type 2 diabetes mellitus risk: A meta-analysis of randomized controlled trials and observational studies?. ### Response: 48.


Instruction: Diabetes Res Clin Pract. May 2019;151:96 -105.

Output: C -reactive protein

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Diabetes Res Clin Pract. May 2019;151:96 -105.. ### Response: C -reactive protein.


Instruction: What is the PMID for Diabetes Res Clin Pract?

Output: 30954511

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the PMID for Diabetes Res Clin Pract?. ### Response: 30954511.


Instruction: What are the results of a systematic review and meta-analysis of observational studies in the general population?

Output: Unintended effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of a systematic review and meta-analysis of observational studies in the general population?. ### Response: Unintended effects.


Instruction: What is the name of the journal that published a meta-analysis of the legacy effects of statins on cardiovascular and all-cause mortality?

Output: BMJ Open

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that published a meta-analysis of the legacy effects of statins on cardiovascular and all-cause mortality?. ### Response: BMJ Open.


Instruction: What did BMC Med report on Mar 22 2014?

Output: Unintended effects of statins from observational studies in the general population: Systematic review and meta -analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did BMC Med report on Mar 22 2014?. ### Response: Unintended effects of statins from observational studies in the general population: Systematic review and meta -analysis.


Instruction: How did the BMJ open report on Oct 4 2018?

Output: 8(9):e020584

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did the BMJ open report on Oct 4 2018?. ### Response: 8(9):e020584.


Instruction: How does statin adherence affect cardiovascular disease and mortality outcomes?

Output: Legacy effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does statin adherence affect cardiovascular disease and mortality outcomes?. ### Response: Legacy effects.


Instruction: What is the PMID for this systematic review?

Output: 25364801

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the PMID for this systematic review?. ### Response: 25364801.


Instruction: How is high burden of recurrent cardiovascular events in heterozygous familial?

Output: hypercholesterolemia: The French fam ilial hypercholesterolemia registry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is high burden of recurrent cardiovascular events in heterozygous familial?. ### Response: hypercholesterolemia: The French fam ilial hypercholesterolemia registry.


Instruction: What is a high burden of recurrent cardiovascular events in heterozygous familial hypercholesterolemia?

Output: The French fam ilial hypercholesterolemia registry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a high burden of recurrent cardiovascular events in heterozygous familial hypercholesterolemia?. ### Response: The French fam ilial hypercholesterolemia registry.


Instruction: What is the PMID: 30270068?

Output: Atherosclerosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the PMID: 30270068?. ### Response: Atherosclerosis.


Instruction: How does lipid lowering treatment affect cardiovascular disease prevalence?

Output: familial hypercholesterolemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does lipid lowering treatment affect cardiovascular disease prevalence?. ### Response: familial hypercholesterolemia.


Instruction: What is the prevalence of familial hypercholesterolemia?

Output: heterozygous

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the prevalence of familial hypercholesterolemia?. ### Response: heterozygous.


Instruction: When did Atherosclerosis issue 284:245- 252?

Output: May 2019

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Atherosclerosis issue 284:245- 252?. ### Response: May 2019.


Instruction: What did Silva M, Matthews ML, Jarvis C, et al. Meta -analysis of drug induced adverse events associated with intensive -dose statin therapy?

Output: 54

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Silva M, Matthews ML, Jarvis C, et al. Meta -analysis of drug induced adverse events associated with intensive -dose statin therapy?. ### Response: 54.


Instruction: What is atorvastatin 80 mg used for?

Output: lipid -lowering treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is atorvastatin 80 mg used for?. ### Response: lipid -lowering treatment.


Instruction: What is the name of the meta-analysis of 17 randomized controlled trials?

Output: atorvastatin 80 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis of 17 randomized controlled trials?. ### Response: atorvastatin 80 mg.


Instruction: How many participants participated in the meta -analysis?

Output: 170,000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many participants participated in the meta -analysis?. ### Response: 170,000.


Instruction: When was the drug Saf published?

Output: May 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the drug Saf published?. ### Response: May 2016.


Instruction: How many participants participated in a meta -analysis of data from 26 randomised trials?

Output: 170,000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many participants participated in a meta -analysis of data from 26 randomised trials?. ### Response: 170,000.


Instruction: What is the PMID for this meta-analysis?

Output: 21067804

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the PMID for this meta-analysis?. ### Response: 21067804.


Instruction: What is the name of the meta-analysis that examined the association between statin therapy and the risk of new onset diabetes?

Output: A meta -analysis of randomized controlled trials and observational studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis that examined the association between statin therapy and the risk of new onset diabetes?. ### Response: A meta -analysis of randomized controlled trials and observational studies.


Instruction: What did Wang S, Cai R, Yuan Y, Varghese Z, Moorhead J, Ruan XZ do?

Output: 57

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Wang S, Cai R, Yuan Y, Varghese Z, Moorhead J, Ruan XZ do?. ### Response: 57.


Instruction: What is the PMID of 28071756?

Output: 21067804.  57. Wang S, Cai R, Yuan Y, Varghese Z, Moorhead J, Ruan XZ. Association between r eductions in low -density lipoprotein cholesterol with statin therapy and the risk of new -onset diabetes: A meta -analysis. Sci Rep. Jan 10 2017;7:39982

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the PMID of 28071756?. ### Response: 21067804.  57. Wang S, Cai R, Yuan Y, Varghese Z, Moorhead J, Ruan XZ. Association between r eductions in low -density lipoprotein cholesterol with statin therapy and the risk of new -onset diabetes: A meta -analysis. Sci Rep. Jan 10 2017;7:39982.


Instruction: What is risk of incident diabetes with intensive -dose compared with moderate-dose?

Output: 58. Preiss D, Seshasai SR, Welsh P, et al. Risk of incident diabetes with intensive -dose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is risk of incident diabetes with intensive -dose compared with moderate-dose?. ### Response: 58. Preiss D, Seshasai SR, Welsh P, et al. Risk of incident diabetes with intensive -dose.


Instruction: What is CAC?

Output: coronary artery calcium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CAC?. ### Response: coronary artery calcium.


Instruction: What is CKD?

Output: chronic kidney disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CKD?. ### Response: chronic kidney disease.


Instruction: Where can you download this article?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you download this article?. ### Response: http://ahajournals.org.


Instruction: When was this article published?

Output: May 1, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this article published?. ### Response: May 1, 2023.


Instruction: What can be selected without the use of echocardiography?

Output: appropriate evidence-based treatment for secondary prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be selected without the use of echocardiography?. ### Response: appropriate evidence-based treatment for secondary prevention.


Instruction: What are some RCTs that provide the current best evidence for secondary prevention treatments?

Output: NASCET (North American Symptomatic Carotid Endarterectomy Trial), ECST (European Carotid Surgery Trial),

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some RCTs that provide the current best evidence for secondary prevention treatments?. ### Response: NASCET (North American Symptomatic Carotid Endarterectomy Trial), ECST (European Carotid Surgery Trial),.


Instruction: What is the name of the European Carotid Surgery Trial?

Output: ECST

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the European Carotid Surgery Trial?. ### Response: ECST.


Instruction: What does CAPRIE stand for?

Output: Clopidogrel versus Aspirin in Patients at Risk of Ischaemic Events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CAPRIE stand for?. ### Response: Clopidogrel versus Aspirin in Patients at Risk of Ischaemic Events.


Instruction: What is PROGRESS?

Output: Perindopril Protection Against Recurrent Stroke Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PROGRESS?. ### Response: Perindopril Protection Against Recurrent Stroke Study.


Instruction: What is SPARCL?

Output: Stroke Prevention by Aggressive Reduction in Cholesterol Levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SPARCL?. ### Response: Stroke Prevention by Aggressive Reduction in Cholesterol Levels.


Instruction: How are the benefits shown in these RCTs expected?

Output: when the same eligibility criteria are applied

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are the benefits shown in these RCTs expected?. ### Response: when the same eligibility criteria are applied.


Instruction: What criteria are applied to patients with known or newly discovered atrial fibrillation by routine ECG?

Output: eligibility criteria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What criteria are applied to patients with known or newly discovered atrial fibrillation by routine ECG?. ### Response: eligibility criteria.


Instruction: What will benefit from oral anticoagulation regardless of echocardiographic findings?

Output: ibrillation by routine ECG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will benefit from oral anticoagulation regardless of echocardiographic findings?. ### Response: ibrillation by routine ECG.


Instruction: Intracardiac thrombus occurs almost exclusively in patients with clinical evidence of heart disease but is rare even in them?

Output: 342

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Intracardiac thrombus occurs almost exclusively in patients with clinical evidence of heart disease but is rare even in them?. ### Response: 342.


Instruction: What is rare even in AIS patients?

Output: Intracardiac thrombus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is rare even in AIS patients?. ### Response: Intracardiac thrombus.


Instruction: Echocardiography for detecting intracardiac thrombus in unselected patients will produce at least how many false-positive as true-positive diagnoses?

Output: as many false-positive as true-positive diagnoses.351

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Echocardiography for detecting intracardiac thrombus in unselected patients will produce at least how many false-positive as true-positive diagnoses?. ### Response: as many false-positive as true-positive diagnoses.351.


Instruction: In large series of patients with AIS who underwent echocardiography, the reported yield of important potentially cardioembolic sources has ranged from what?

Output: 0.2% to 55%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In large series of patients with AIS who underwent echocardiography, the reported yield of important potentially cardioembolic sources has ranged from what?. ### Response: 0.2% to 55%.


Instruction: What has ranged from 0.2% to 55% in cardioembolic sources?

Output: reported yield

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has ranged from 0.2% to 55% in cardioembolic sources?. ### Response: reported yield.


Instruction: What is the result of differences in categorization of cardiac pathology?

Output: Much of this discrepancy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the result of differences in categorization of cardiac pathology?. ### Response: Much of this discrepancy.


Instruction: What is the risk of recurrent stroke associated with many echocardiographic lesions?

Output: The efficacy of treatment in reducing the risk of recurrent stroke associated with many of these echocardiographic lesions is unknown

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of recurrent stroke associated with many echocardiographic lesions?. ### Response: The efficacy of treatment in reducing the risk of recurrent stroke associated with many of these echocardiographic lesions is unknown.


Instruction: What has been shown to be better than standard medical therapy?

Output: evidence-based treatment for secondary prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been shown to be better than standard medical therapy?. ### Response: evidence-based treatment for secondary prevention.


Instruction: Different authors have concluded that routine echocardiography is indicated or what?

Output: contraindicated

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Different authors have concluded that routine echocardiography is indicated or what?. ### Response: contraindicated.


Instruction: How many RCTs have evaluated mechanical closure of echocardiographically detected PFO to prevent recurrent stroke in patients without an obvious cause for their index stroke?

Output: Six

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs have evaluated mechanical closure of echocardiographically detected PFO to prevent recurrent stroke in patients without an obvious cause for their index stroke?. ### Response: Six.


Instruction: What criteria did these trials have?

Output: highly restrictive eligibility criteria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What criteria did these trials have?. ### Response: highly restrictive eligibility criteria.


Instruction: Echocardiography is reasonable in selected patients as part of a comprehensive evaluation?

Output: Echocardiography is reasonable in selected patients as part of a comprehensive evaluation to determine if they meet the eligibility criteria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Echocardiography is reasonable in selected patients as part of a comprehensive evaluation?. ### Response: Echocardiography is reasonable in selected patients as part of a comprehensive evaluation to determine if they meet the eligibility criteria.


Instruction: What criteria did the RCTs meet to determine if they met the eligibility criteria?

Output: did not require echocardiography for patient selection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What criteria did the RCTs meet to determine if they met the eligibility criteria?. ### Response: did not require echocardiography for patient selection.


Instruction: What was investigated for prevention of recurrent stroke?

Output: mechanical closure of PFO

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was investigated for prevention of recurrent stroke?. ### Response: mechanical closure of PFO.


Instruction: What is a conditional recommendation based on low certainty in the evidence about effects?

Output: administration of P-gp inhibitors or inducers or strong inhibitors orinducers of CYP enzymes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a conditional recommendation based on low certainty in the evidence about effects?. ### Response: administration of P-gp inhibitors or inducers or strong inhibitors orinducers of CYP enzymes.


Instruction: The recommen-dation places a high value on avoiding the uncertainty in what?

Output: DOACanticoagulant response

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The recommen-dation places a high value on avoiding the uncertainty in what?. ### Response: DOACanticoagulant response.


Instruction: What is a low value on avoiding the burden of warfarinor LMWH therapy?

Output: low certainty in the evidence about effects ÅÅ◯◯

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a low value on avoiding the burden of warfarinor LMWH therapy?. ### Response: low certainty in the evidence about effects ÅÅ◯◯.


Instruction: Patients strongly adverse to INR monitoring ordaily injections are likely to remain on what?

Output: DOACs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients strongly adverse to INR monitoring ordaily injections are likely to remain on what?. ### Response: DOACs.


Instruction: AvoidingDOACs in favor of VKA may be favored in the very elderly, those withcompromised renal function and situations where multiple injections occur?

Output: multiple drugsaffecting P-gp and/or CYP enzymes are coprescribed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: AvoidingDOACs in favor of VKA may be favored in the very elderly, those withcompromised renal function and situations where multiple injections occur?. ### Response: multiple drugsaffecting P-gp and/or CYP enzymes are coprescribed.


Instruction: What are some situations where multiple drugsaffecting P-gp and/or CYP enzymes are coprescribed?

Output: renal function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some situations where multiple drugsaffecting P-gp and/or CYP enzymes are coprescribed?. ### Response: renal function.


Instruction: What are the patient-important outcomes associated with concomitant administration of DOACs?

Output: compared with DOACs alone or comparedwith other anticoagulants coadministered with strong P-gp orCYP3A4 inhibitors/inducers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the patient-important outcomes associated with concomitant administration of DOACs?. ### Response: compared with DOACs alone or comparedwith other anticoagulants coadministered with strong P-gp orCYP3A4 inhibitors/inducers.


Instruction: What type of testing should be used for patients receiving maintenance VKA therapy for treatment of VTE?

Output: home point-of-care INR testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of testing should be used for patients receiving maintenance VKA therapy for treatment of VTE?. ### Response: home point-of-care INR testing.


Instruction: What is the ASH guideline panel used for?

Output: patients receiving maintenance VKA therapy for treatmentof VTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ASH guideline panel used for?. ### Response: patients receiving maintenance VKA therapy for treatmentof VTE.


Instruction: What type of therapy is recommended for treatmentof VTE?

Output: maintenance VKA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is recommended for treatmentof VTE?. ### Response: maintenance VKA.


Instruction: What is PST?

Output: home point-of-care INR testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PST?. ### Response: home point-of-care INR testing.


Instruction: How many systematic reviews did we find that addressed this question?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many systematic reviews did we find that addressed this question?. ### Response: 1.


Instruction: What did we perform on this subset of studies?

Output: meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did we perform on this subset of studies?. ### Response: meta-analysis.


Instruction: How many studies did we include measuring outcomes relevant to PST?

Output: 11

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies did we include measuring outcomes relevant to PST?. ### Response: 11.


Instruction: What did three studies report the effect of PST on mortality?

Output: 31,33,36,41,42Recurrent PE and DVT rates were estimated

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did three studies report the effect of PST on mortality?. ### Response: 31,33,36,41,42Recurrent PE and DVT rates were estimated.


Instruction: How were PE and DVT rates estimated?

Output: by extrapol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How were PE and DVT rates estimated?. ### Response: by extrapol.


Instruction: How many studies were used to estimate recurrent PE and DVT rates?

Output: 9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were used to estimate recurrent PE and DVT rates?. ### Response: 9.


Instruction: Who presented the data at the 6th National Conference of the Anticoagulation Forum, May 2001?

Output: Scott Kaatz

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who presented the data at the 6th National Conference of the Anticoagulation Forum, May 2001?. ### Response: Scott Kaatz.


Instruction: How many studies have been published and 1 unpublished?

Output: 8published and 1 unpublished [Scott Kaatz, data presented atthe 6th National Conference of the Anticoagulation Forum, May2001])30,31,33,34,36,38-42to baseline recurrent VTE rates from theLMWH/VKA arms of recent randomized, controlled trials (RCTs).Nine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies have been published and 1 unpublished?. ### Response: 8published and 1 unpublished [Scott Kaatz, data presented atthe 6th National Conference of the Anticoagulation Forum, May2001])30,31,33,34,36,38-42to baseline recurrent VTE rates from theLMWH/VKA arms of recent randomized, controlled trials (RCTs).Nine.


Instruction: Who presented the data presented at the 6th National Conference of the AnticoagulationForum, May 2001?

Output: Scott Kaatz

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who presented the data presented at the 6th National Conference of the AnticoagulationForum, May 2001?. ### Response: Scott Kaatz.


Instruction: How manystudies reported information on TTR?

Output: 6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How manystudies reported information on TTR?. ### Response: 6.


Instruction: What is the EtD framework shown online?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the EtD framework shown online?. ### Response: https://dbep.gradepro.org.


Instruction: IOM Standards for Developing Trustworthy Clinical Practice Guidelines Part of the KDIGO Process?

Output:  an explanation of the part played by values, opinion, theory, and clinical experience in deriving the recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: IOM Standards for Developing Trustworthy Clinical Practice Guidelines Part of the KDIGO Process?. ### Response:  an explanation of the part played by values, opinion, theory, and clinical experience in deriving the recommendation.


Instruction: What is an explanation of the part played by values, opinion, theory, and clinical experience in deriving the recommendation?

Output: IOM Standards for Developing Trustworthy Clinical Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an explanation of the part played by values, opinion, theory, and clinical experience in deriving the recommendation?. ### Response: IOM Standards for Developing Trustworthy Clinical Practice Guidelines.


Instruction: What should a recommendation include in light of the preceding bullets?

Output: A rating of the strength of the recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should a recommendation include in light of the preceding bullets?. ### Response: A rating of the strength of the recommendation.


Instruction: A description and explanation of any differences of opinion regarding the recommendation?

Output: IOM Standards for Developing Trustworthy Clinical Practice Guidelines Part of KDIGO Process?  an explanation of the part played by values, opinion, theory, and clinical experience in deriving the recommendation. Yes  A rating of the level of confidence in (c ertainty regarding) t he evidence underpinning the recommendation Yes  A rating of the strength of the recommendation in light of the preceding bullets Yes 

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A description and explanation of any differences of opinion regarding the recommendation?. ### Response: IOM Standards for Developing Trustworthy Clinical Practice Guidelines Part of KDIGO Process?  an explanation of the part played by values, opinion, theory, and clinical experience in deriving the recommendation. Yes  A rating of the level of confidence in (c ertainty regarding) t he evidence underpinning the recommendation Yes  A rating of the strength of the recommendation in light of the preceding bullets Yes .


Instruction: Recommendations should be articulated in a standardized form detailing exactly what the recommended action is?

Output: Articulation of Recommendations  6.1 Recommendations should be articulated in a standardized form detailing precisely what the recommended action is, and under what circumstances it should be performed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Recommendations should be articulated in a standardized form detailing exactly what the recommended action is?. ### Response: Articulation of Recommendations  6.1 Recommendations should be articulated in a standardized form detailing precisely what the recommended action is, and under what circumstances it should be performed.


Instruction: Strong recommendations should be worded so that what can be evaluated?

Output: compliance with the recommendation(s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Strong recommendations should be worded so that what can be evaluated?. ### Response: compliance with the recommendation(s.


Instruction: How can compliance with the recommendation(s) be evaluated?

Output: Strong recommendations should be worded

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can compliance with the recommendation(s) be evaluated?. ### Response: Strong recommendations should be worded.


Instruction: Who should include a full spectrum of relevant stakeholders?

Output: External reviewers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should include a full spectrum of relevant stakeholders?. ### Response: External reviewers.


Instruction: Who should consider all external reviewer comments?

Output: The GDG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should consider all external reviewer comments?. ### Response: The GDG.


Instruction: What should the GDG keep a written record of?

Output: the rationale for m odifying or not modifying a CPG in response to reviewers’ comments

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should the GDG keep a written record of?. ### Response: the rationale for m odifying or not modifying a CPG in response to reviewers’ comments.


Instruction: What should reviewers keep a written record of in response to reviewers' comments?

Output: the rationale for m odifying or not modifying a CPG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should reviewers keep a written record of in response to reviewers' comments?. ### Response: the rationale for m odifying or not modifying a CPG.


Instruction: What should be made at the external review stage or immediately following it?

Output: A draft of the CPG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be made at the external review stage or immediately following it?. ### Response: A draft of the CPG.


Instruction: What should be made available to the general public for comment?

Output: A draft of the CPG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be made available to the general public for comment?. ### Response: A draft of the CPG.


Instruction: How should the CPG publication date, date of pertinent syst ematic evidence review, and proposed date for future publication be updated?

Output: documented in the CPG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How should the CPG publication date, date of pertinent syst ematic evidence review, and proposed date for future publication be updated?. ### Response: documented in the CPG.


Instruction: What should be documented in the CPG?

Output: future CPG review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be documented in the CPG?. ### Response: future CPG review.


Instruction: How many years from the publication date will the requirement for an update be assessed?

Output: five

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many years from the publication date will the requirement for an update be assessed?. ### Response: five.


Instruction: What should be monitored regularly follo wing CPG publication to identify the emergence of new, potentially relevant evidence and evaluate the validity of the CPG?

Output: Literature

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be monitored regularly follo wing CPG publication to identify the emergence of new, potentially relevant evidence and evaluate the validity of the CPG?. ### Response: Literature.


Instruction: CPGs should be updated when new evidence suggests the need for what?

Output: modification of clinically important recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: CPGs should be updated when new evidence suggests the need for what?. ### Response: modification of clinically important recommendations.


Instruction: What should be updated when new evidence suggests the need for modification of clinically important recommendations?

Output: CPGs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be updated when new evidence suggests the need for modification of clinically important recommendations?. ### Response: CPGs.


Instruction: What should a CPG be updated if new evidence shows that a recommended intervention causes previously unknown substantial harm?

Output: CPGs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should a CPG be updated if new evidence shows that a recommended intervention causes previously unknown substantial harm?. ### Response: CPGs.


Instruction: What is superior to a previously reco mmended intervention from an efficacy or harms perspective?

Output: a new intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is superior to a previously reco mmended intervention from an efficacy or harms perspective?. ### Response: a new intervention.


Instruction: What can a recommendation be applied to?

Output: new populations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can a recommendation be applied to?. ### Response: new populations.


Instruction: What is not recommended for patients who undergo diagnostic esopha-gogastroduodenoscopy?

Output: The administration of prophylactic antibiotics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended for patients who undergo diagnostic esopha-gogastroduodenoscopy?. ### Response: The administration of prophylactic antibiotics.


Instruction: What is Class III, LOEB?

Output: diagnostic esopha-gogastroduodenoscopy or colonoscopy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Class III, LOEB?. ### Response: diagnostic esopha-gogastroduodenoscopy or colonoscopy.


Instruction: What did previous AHA guidelines list for GI or GU tract procedures for which IE prophylaxis was recommended?

Output: antimicrobial-resistant strains

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did previous AHA guidelines list for GI or GU tract procedures for which IE prophylaxis was recommended?. ### Response: antimicrobial-resistant strains.


Instruction: What was not recommended for GU or GI tract procedures?

Output: The administration of prophylactic antibiotics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not recommended for GU or GI tract procedures?. ### Response: The administration of prophylactic antibiotics.


Instruction: A large number of diagnostic andtherapeutic procedures that involve the GI, hepatobiliary, or what else may cause transient enterococcal bacteremia?

Output: GU tract

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A large number of diagnostic andtherapeutic procedures that involve the GI, hepatobiliary, or what else may cause transient enterococcal bacteremia?. ### Response: GU tract.


Instruction: What can cause transient enterococcal bacteremia?

Output: that involve the GI, hepatobiliary,or GU tract

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can cause transient enterococcal bacteremia?. ### Response: that involve the GI, hepatobiliary,or GU tract.


Instruction: What has not been studied as extensively as the possible association with dental procedures?

Output: The possible association between GI or GU tract proce-dures and IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has not been studied as extensively as the possible association with dental procedures?. ### Response: The possible association between GI or GU tract proce-dures and IE.


Instruction: The cases of IE temporally associated with a GI or GU tract proce-dure are what?

Output: anecdotal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The cases of IE temporally associated with a GI or GU tract proce-dure are what?. ### Response: anecdotal.


Instruction: No published data demonstrate a conclusive link between procedures of the GI or GU tractand the development of what?

Output: IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No published data demonstrate a conclusive link between procedures of the GI or GU tractand the development of what?. ### Response: IE.


Instruction: No studies existthat demonstrate that the administration of antimicrobialprophylaxis prevents IE in association with procedures performed on the gastrointestinal tract?

Output: no published studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No studies existthat demonstrate that the administration of antimicrobialprophylaxis prevents IE in association with procedures performed on the gastrointestinal tract?. ### Response: no published studies.


Instruction: What has been a dramatic increase in the frequency of?

Output: antimicrobial-resistant strains of enterococci

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been a dramatic increase in the frequency of?. ### Response: antimicrobial-resistant strains of enterococci.


Instruction: What was recom-mended for IE prophylaxis in previous AHA guidelines?

Output: GI or GU tract procedures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was recom-mended for IE prophylaxis in previous AHA guidelines?. ### Response: GI or GU tract procedures.


Instruction: What is the effect of multiresistant strains of enterococci on prevention of IE in patients who undergo GI or GUtract procedures?

Output: increased frequency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of multiresistant strains of enterococci on prevention of IE in patients who undergo GI or GUtract procedures?. ### Response: increased frequency.


Instruction: What adds further doubt about the efficacy ofprophylactic therapy?

Output: high prevalence of resistantstrains of enterococci

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What adds further doubt about the efficacy ofprophylactic therapy?. ### Response: high prevalence of resistantstrains of enterococci.


Instruction: Patients with infections of the GI and GU tract may have what?

Output: intermittent or sustained enterococcal bacteremia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with infections of the GI and GU tract may have what?. ### Response: intermittent or sustained enterococcal bacteremia.


Instruction: What type of bacteremia are infections of the GI or GU tract susceptible to?

Output: enterococcal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of bacteremia are infections of the GI or GU tract susceptible to?. ### Response: enterococcal.


Instruction: What is the name of the condition in which a patient has an established GIor GU bacterial infection or receives antibiotic therapy?

Output: Table 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the condition in which a patient has an established GIor GU bacterial infection or receives antibiotic therapy?. ### Response: Table 3.


Instruction: What type of sepsis is associated with a GI or GUtract procedure?

Output: wound infection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of sepsis is associated with a GI or GUtract procedure?. ### Response: wound infection.


Instruction: What are some antibiotics that may be included in an antibiotic regimen?

Output: penicillin,ampicillin, piperacillin, or vancomycin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some antibiotics that may be included in an antibiotic regimen?. ### Response: penicillin,ampicillin, piperacillin, or vancomycin.


Instruction: No published studies demonstrate that such therapy would prevent what?

Output: enterococcal IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No published studies demonstrate that such therapy would prevent what?. ### Response: enterococcal IE.


Instruction: What is an enterococcal IE?

Output: bacteremia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an enterococcal IE?. ### Response: bacteremia.


Instruction: What is a class IIb, LOE B procedure?

Output: antibiotic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a class IIb, LOE B procedure?. ### Response: antibiotic therapy.


Instruction: If the procedure is scheduled for an elective cystoscopy, what may be reasonable?

Output: the antibiotic regimeninclude an agent active against enterococci

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: If the procedure is scheduled for an elective cystoscopy, what may be reasonable?. ### Response: the antibiotic regimeninclude an agent active against enterococci.


Instruction: What is the preferred agent for enterococci?

Output: penicillin,ampicillin, piperacillin, or vancomycin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the preferred agent for enterococci?. ### Response: penicillin,ampicillin, piperacillin, or vancomycin.


Instruction: What is a class IIb, LOE B?

Output: antibiotic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a class IIb, LOE B?. ### Response: antibiotic therapy.


Instruction: What is MERIT-HF?

Output: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is MERIT-HF?. ### Response: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure.


Instruction: What is the name of the Randomised Intervention Trial in Congestive Heart Failure?

Output: MERIT-HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Randomised Intervention Trial in Congestive Heart Failure?. ### Response: MERIT-HF.


Instruction: When did the Lancet issue 359:2001-2007?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Lancet issue 359:2001-2007?. ### Response: 2003.


Instruction: What is the name of the randomised controlled trial that compares carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure?

Output: Carvedilol Or Metoprolol European Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised controlled trial that compares carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure?. ### Response: Carvedilol Or Metoprolol European Trial.


Instruction: What is COMET?

Output: randomised controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is COMET?. ### Response: randomised controlled trial.


Instruction: When was the Lancet 362:7–13?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Lancet 362:7–13?. ### Response: 2003.


Instruction: What contributes to the systemic hemodynamic effects of chronic angio-tensin-converting enzyme inhibition in patients with heart failure?

Output: Bradykinin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What contributes to the systemic hemodynamic effects of chronic angio-tensin-converting enzyme inhibition in patients with heart failure?. ### Response: Bradykinin.


Instruction: What does Bradykinin contribute to?

Output: systemic hemodynamic effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Bradykinin contribute to?. ### Response: systemic hemodynamic effects.


Instruction: When did Arterioscler Thromb Vasc Biol. 2004;24:1043-1048?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Arterioscler Thromb Vasc Biol. 2004;24:1043-1048?. ### Response: 2004.


Instruction: What is the effect of captopril on mortality and morbidity in patients with left ventricular dysfunction?

Output: survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of captopril on mortality and morbidity in patients with left ventricular dysfunction?. ### Response: survival.


Instruction: What is the effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarc-tion?

Output: Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarc-tion: results of the Survival and Ventricular Enlargement Trial: the SA VE Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarc-tion?. ### Response: Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarc-tion: results of the Survival and Ventricular Enlargement Trial: the SA VE Investigators.


Instruction: What was the result of the SA VE Investigators?

Output: Effect of captopril on mortality and morbidity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the result of the SA VE Investigators?. ### Response: Effect of captopril on mortality and morbidity.


Instruction: How long did enala-pril last?

Output: 12-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did enala-pril last?. ### Response: 12-year.


Instruction: What is the effect of enala-pril on 12-year survival and life expectancy in patients with left ventricu-lar systolic dysfunction?

Output: Effect of enala-pril on 12-year survival and life expectancy in patients with left ventricu-lar systolic dysfunction: a follow-up study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of enala-pril on 12-year survival and life expectancy in patients with left ventricu-lar systolic dysfunction?. ### Response: Effect of enala-pril on 12-year survival and life expectancy in patients with left ventricu-lar systolic dysfunction: a follow-up study.


Instruction: When did a follow-up study take place?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did a follow-up study take place?. ### Response: 2003.


Instruction: What did the SOLVD Investigators do in asymptomatic patients with reduced left ventricular ejection fractions?

Output: development of heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the SOLVD Investigators do in asymptomatic patients with reduced left ventricular ejection fractions?. ### Response: development of heart failure.


Instruction: What was the result of the Cooperative North Scandinavian Enalapril Survival Study?

Output: Effects of enalapril on mortality in severe congestive heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the result of the Cooperative North Scandinavian Enalapril Survival Study?. ### Response: Effects of enalapril on mortality in severe congestive heart failure.


Instruction: When was the CONSENSUS Trial Study Group conducted?

Output: 1987

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the CONSENSUS Trial Study Group conducted?. ### Response: 1987.


Instruction: What is the N Engl J Med. 1987;316:1429–1435?

Output: Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS): the CONSENSUS Trial Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the N Engl J Med. 1987;316:1429–1435?. ### Response: Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS): the CONSENSUS Trial Study Group.


Instruction: What is another name for Trial Study Group?

Output: CONSENSUS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for Trial Study Group?. ### Response: CONSENSUS.


Instruction: What is the effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure?

Output: mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure?. ### Response: mortality.


Instruction: What drug is compared with hydralazine-isosorbide dinitrate?

Output: enalapril

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug is compared with hydralazine-isosorbide dinitrate?. ### Response: enalapril.


Instruction: What is the N Engl J Med. 1991;325:293–302?

Output: enalapril

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the N Engl J Med. 1991;325:293–302?. ### Response: enalapril.


Instruction: What are the SOLVD Investigators?

Output: Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the SOLVD Investigators?. ### Response: Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure.


Instruction: How long after surgical or medical ther -apy for coronary artery disease does cognitive function last?

Output: 6 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after surgical or medical ther -apy for coronary artery disease does cognitive function last?. ### Response: 6 years.


Instruction: What is the name of the group of investigators that studied Cognition 6 years after surgery?

Output: ISPOCD2 Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group of investigators that studied Cognition 6 years after surgery?. ### Response: ISPOCD2 Investigators.


Instruction: What is the name of the investigators that investigated cognitive dys-function in middle-aged patients?

Output: ISPOCD2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the investigators that investigated cognitive dys-function in middle-aged patients?. ### Response: ISPOCD2.


Instruction: When did Rasmussen LS and Moller JT publish their findings?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Rasmussen LS and Moller JT publish their findings?. ### Response: 2002.


Instruction: What was the result of Central nervous system dysfunction after anesthesia in the geriatric patient?

Output: decline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the result of Central nervous system dysfunction after anesthesia in the geriatric patient?. ### Response: decline.


Instruction: What are the predictors of cognitive dysfunction after major noncardiac surgery?

Output: Anesthesiology. 2008;108:18–30. doi: 10.1097/01.anes.0000296071.19434.1e. 386. Ho PM, Arciniegas DB, Grigsby J, McCarthy M Jr, McDonald GO, Moritz TE, Shroyer AL, Sethi GK, Henderson WG, London MJ, VillaNueva CB, Grover FL, Hammermeister KE. Predictors of cogni-tive decline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the predictors of cognitive dysfunction after major noncardiac surgery?. ### Response: Anesthesiology. 2008;108:18–30. doi: 10.1097/01.anes.0000296071.19434.1e. 386. Ho PM, Arciniegas DB, Grigsby J, McCarthy M Jr, McDonald GO, Moritz TE, Shroyer AL, Sethi GK, Henderson WG, London MJ, VillaNueva CB, Grover FL, Hammermeister KE. Predictors of cogni-tive decline.


Instruction: What is the doi: 10.1097/01.anes.0000296071.19434.1e?

Output: Predictors of cognitive dysfunction after major noncardiac surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the doi: 10.1097/01.anes.0000296071.19434.1e?. ### Response: Predictors of cognitive dysfunction after major noncardiac surgery.


Instruction: What is the name of the surgeon who performed coronary artery bypass graft surgery?

Output: Chrolavicius S, Yusuf S

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the surgeon who performed coronary artery bypass graft surgery?. ### Response: Chrolavicius S, Yusuf S.


Instruction: What is one of the factors that can predict cognitive decline following coronary bypass?

Output: Magnetic resonance imaging findings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the factors that can predict cognitive decline following coronary bypass?. ### Response: Magnetic resonance imaging findings.


Instruction: When was the Ann Thorac Surg 77:597-603?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Ann Thorac Surg 77:597-603?. ### Response: 2004.


Instruction: What imaging findings are associated with postoperative neurologic dys-function in elderly patients undergoing coronary artery bypass grafting?

Output: Magnetic resonance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What imaging findings are associated with postoperative neurologic dys-function in elderly patients undergoing coronary artery bypass grafting?. ### Response: Magnetic resonance.


Instruction: Ann Thorac Surg. 2001;72:137–142. What is the name of the study that found magnetic resonance imaging findings in elderly people?

Output: Octopus Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Ann Thorac Surg. 2001;72:137–142. What is the name of the study that found magnetic resonance imaging findings in elderly people?. ### Response: Octopus Study Group.


Instruction: What is the name of the study group that evaluated cognitive outcomes after coronary artery bypass graft surgery?

Output: Octopus Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study group that evaluated cognitive outcomes after coronary artery bypass graft surgery?. ### Response: Octopus Study Group.


Instruction: When did the Octopus Study Group conduct a ran-domized trial?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Octopus Study Group conduct a ran-domized trial?. ### Response: 2002.


Instruction: What did Marasco SF, Sharwood LN, Abramson MJ find?

Output: No improvement in neuro-cognitive outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Marasco SF, Sharwood LN, Abramson MJ find?. ### Response: No improvement in neuro-cognitive outcomes.


Instruction: What did Sharwood LN, Abramson MJ, and Octopus Study Group find about off-pump versus on-push coronary revascu-larisation?

Output: No improvement in neuro-cognitive outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Sharwood LN, Abramson MJ, and Octopus Study Group find about off-pump versus on-push coronary revascu-larisation?. ### Response: No improvement in neuro-cognitive outcomes.


Instruction: What is the name of the meta-analysis that found no improvement in neuro-cognitive outcomes?

Output: Octopus Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis that found no improvement in neuro-cognitive outcomes?. ### Response: Octopus Study Group.


Instruction: When did Eur J Cardiothorac Surg issue 33:961-970?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Eur J Cardiothorac Surg issue 33:961-970?. ### Response: 2008.


Instruction: What is the Octopus Study Group?

Output: Cognitive and cardiac outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Octopus Study Group?. ### Response: Cognitive and cardiac outcomes.


Instruction: Cognitive and cardiac outcomes 5 years after off-pump vs what?

Output: on-pump coronary artery bypass graft surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cognitive and cardiac outcomes 5 years after off-pump vs what?. ### Response: on-pump coronary artery bypass graft surgery.


Instruction: JAMA. 2007;297:701–708. doi: 10.1001/jama.297.7.701.

Output: Cognitive and cardiac outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: JAMA. 2007;297:701–708. doi: 10.1001/jama.297.7.701.. ### Response: Cognitive and cardiac outcomes.


Instruction: What is the name of the investigator who investigated the effects of off-pump and on-push coronary-artery bypass grafting?

Output: Yusuf S

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the investigator who investigated the effects of off-pump and on-push coronary-artery bypass grafting?. ### Response: Yusuf S.


Instruction: What is a major risk factor for coronary heart disease?

Output: obe-sity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a major risk factor for coronary heart disease?. ### Response: obe-sity.


Instruction: What is the name of the study that investigated the effects of off-pump and on-push coronary-artery bypass grafting at 1 year?

Output: CORONARY Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the effects of off-pump and on-push coronary-artery bypass grafting at 1 year?. ### Response: CORONARY Investigators.


Instruction: When was the N Engl J Med 368:1179-1188?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the N Engl J Med 368:1179-1188?. ### Response: 2013.


Instruction: Who is the AHA Nutrition Committee?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the AHA Nutrition Committee?. ### Response: American Heart Association.