Instruction: Adenosine may be useful diagnostically, to unmask what?

Output: atrial flutter or AT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Adenosine may be useful diagnostically, to unmask what?. ### Response: atrial flutter or AT.


Instruction: What should women with asymptomatic carotid stenosis be screened for?

Output: other treatable risk factors for stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should women with asymptomatic carotid stenosis be screened for?. ### Response: other treatable risk factors for stroke.


Instruction: What should be instituted in women who are to undergo CEA?

Output: appropriate lifestyle changes and medi-cal therapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be instituted in women who are to undergo CEA?. ### Response: appropriate lifestyle changes and medi-cal therapies.


Instruction: What is recommended in women who are to undergo CEA unless contraindicated?

Output: aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended in women who are to undergo CEA unless contraindicated?. ### Response: aspirin.


Instruction: What was used in every major trial that demonstrated efficacy of CEA (Class I; Level of Evidence C).

Output: aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was used in every major trial that demonstrated efficacy of CEA (Class I; Level of Evidence C).. ### Response: aspirin.


Instruction: What can be useful in highly selected patients with an asymptomatic carotid artery?

Output: appropriate interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be useful in highly selected patients with an asymptomatic carotid artery?. ### Response: appropriate interventions.


Instruction: What can be useful in highly selected patients with an asymptomatic carotid stenosis?

Output: morbidity/mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be useful in highly selected patients with an asymptomatic carotid stenosis?. ### Response: morbidity/mortality.


Instruction: What is recommended for women with recent TIA or IS within the past 6 months?

Output: CEA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for women with recent TIA or IS within the past 6 months?. ### Response: CEA.


Instruction: What percentage of women have severe carotid artery stenosis?

Output: 70%–99%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of women have severe carotid artery stenosis?. ### Response: 70%–99%).


Instruction: What is recommended if the periop-erative morbidity and mortality risk is estimated to be 6% (Class I; Level of Evidence A)205?

Output: CEA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended if the periop-erative morbidity and mortality risk is estimated to be 6% (Class I; Level of Evidence A)205?. ### Response: CEA.


Instruction: How is CEA rec-ommended for women with recent TIA or IS?

Output: depending on patient-specific factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is CEA rec-ommended for women with recent TIA or IS?. ### Response: depending on patient-specific factors.


Instruction: What is rec-ommended depending on patient-specific factors?

Output: CEA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is rec-ommended depending on patient-specific factors?. ### Response: CEA.


Instruction: What is the perioperative morbidity and mortality risk estimated to be?

Output: <6%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the perioperative morbidity and mortality risk estimated to be?. ### Response: <6%.


Instruction: When CEA is indicated for women with TIA or stroke, what is reasonable rather than delaying surgery?

Output: surgery within 2 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When CEA is indicated for women with TIA or stroke, what is reasonable rather than delaying surgery?. ### Response: surgery within 2 weeks.


Instruction: What is reasonable in women with diabetes mellitus unless contraindicated?

Output: Aspirin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable in women with diabetes mellitus unless contraindicated?. ### Response: Aspirin therapy.


Instruction: What is a high-risk (ie, 10-year predicted CVD risk)?

Output: ≥10%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a high-risk (ie, 10-year predicted CVD risk)?. ### Response: ≥10%).


Instruction: What should be substituted if a high-risk woman has an indication for aspirin but is intolerant of it?

Output: clopidogrel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be substituted if a high-risk woman has an indication for aspirin but is intolerant of it?. ### Response: clopidogrel.


Instruction: What can be useful in women 65 years of age?

Output: Aspirin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be useful in women 65 years of age?. ### Response: Aspirin therapy.


Instruction: How many mg/d or 100 mg every other day is recommended for women 65 years of age?

Output: 81

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mg/d or 100 mg every other day is recommended for women 65 years of age?. ### Response: 81.


Instruction: If BP is controlled, the benefit for IS and MI prevention is likely to outweigh the risk of what?

Output: gastrointestinal bleeding and hemorrhagic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: If BP is controlled, the benefit for IS and MI prevention is likely to outweigh the risk of what?. ### Response: gastrointestinal bleeding and hemorrhagic stroke.


Instruction: What is Class IIa; Level of Evidence B?

Output: Aspirin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Class IIa; Level of Evidence B?. ### Response: Aspirin therapy.


Instruction: What is a Class IIb; Level of Evidence B) and may be reasonable for women 65 years of age for IS prevention?

Output: Aspirin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a Class IIb; Level of Evidence B) and may be reasonable for women 65 years of age for IS prevention?. ### Response: Aspirin therapy.


Instruction: What has been advocated to clinically classify indi-viduals according to their overall risk?

Output: Risk scores

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been advocated to clinically classify indi-viduals according to their overall risk?. ### Response: Risk scores.


Instruction: Classify indi-viduals according to their overall risk to guide what?

Output: prevention and treatment recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Classify indi-viduals according to their overall risk to guide what?. ### Response: prevention and treatment recommendations.


Instruction: The goal of such scores is to accurately classify individuals as high or low risk so that high-risk individuals receive appropriate interventions to reduce risk?

Output: Risk scores

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The goal of such scores is to accurately classify individuals as high or low risk so that high-risk individuals receive appropriate interventions to reduce risk?. ### Response: Risk scores.


Instruction: How many general cardiovascular risk scores?

Output: 438,439

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many general cardiovascular risk scores?. ### Response: 438,439.


Instruction: How many stroke-specific scores are there?

Output: 438,439

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many stroke-specific scores are there?. ### Response: 438,439.


Instruction: What type of models are not specific to women?

Output: Risk prediction models

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of models are not specific to women?. ### Response: Risk prediction models.


Instruction: What is a potassium-channel block er?

Output: amiodar one

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a potassium-channel block er?. ### Response: amiodar one.


Instruction: What do wit hout rat e contr ol suggest?

Output: litt le difference betw een t he 2 groups

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do wit hout rat e contr ol suggest?. ### Response: litt le difference betw een t he 2 groups.


Instruction: What was not included in t he 2014 guideline?

Output: potassium-channel block er (amiodar one) wit h or wit hout rat e contr ol suggest ed litt le difference betw een t he 2 groups. Based on t his e vidence and t heir e xperience, t he committ ee decided t hat rh ythm contr ol could be consider ed but t hat t he evidence no longer suppor ted the str onger r ecommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not included in t he 2014 guideline?. ### Response: potassium-channel block er (amiodar one) wit h or wit hout rat e contr ol suggest ed litt le difference betw een t he 2 groups. Based on t his e vidence and t heir e xperience, t he committ ee decided t hat rh ythm contr ol could be consider ed but t hat t he evidence no longer suppor ted the str onger r ecommendation.


Instruction: The committ ee not ed that post operativ e atrial fibrillation oft en resolves naturally?

Output: most people under going mitral v alve sur gery wit h pre-existing atrial fibrillation w ould under go left atrial surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committ ee not ed that post operativ e atrial fibrillation oft en resolves naturally?. ### Response: most people under going mitral v alve sur gery wit h pre-existing atrial fibrillation w ould under go left atrial surgery.


Instruction: Operativ e atrial fibrillation oft en resolv es naturally, meaning t hat rate contr ol rat her than rh ythm control ma y be a suitable option f or some people?

Output: people wit h pre-existing atrial fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Operativ e atrial fibrillation oft en resolv es naturally, meaning t hat rate contr ol rat her than rh ythm control ma y be a suitable option f or some people?. ### Response: people wit h pre-existing atrial fibrillation.


Instruction: R educing the emphasis on what strat egies will allo w rat e-contr-ol strat gies?

Output: rh ythm-contr ol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: R educing the emphasis on what strat egies will allo w rat e-contr-ol strat gies?. ### Response: rh ythm-contr ol.


Instruction: What will allo w rat e-contr ol strat egies be considered if appr opriat e for the person?

Output: R educing the emphasis on rh ythm-contr ol strat egies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will allo w rat e-contr ol strat egies be considered if appr opriat e for the person?. ### Response: R educing the emphasis on rh ythm-contr ol strat egies.


Instruction: The committ ee were also aware of t he risk of adv erse e vents if amiodar one, a rh ythm control drug, is taken?

Output: awar e of t he risk of adv erse e vents if amiodar one, a rh ythm contr ol drug, is tak en long-t erm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committ ee were also aware of t he risk of adv erse e vents if amiodar one, a rh ythm control drug, is taken?. ### Response: awar e of t he risk of adv erse e vents if amiodar one, a rh ythm contr ol drug, is tak en long-t erm.


Instruction: How long should a rh ythm-contr ol strat egy be reassessed?

Output: 6 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long should a rh ythm-contr ol strat egy be reassessed?. ### Response: 6 weeks.


Instruction: What should be r oximat ely 6 weeks?

Output: drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be r oximat ely 6 weeks?. ### Response: drugs.


Instruction: How long should a committee agr eed t hat 6 weeks be r eassessed at?

Output: appr oximat ely 6 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long should a committee agr eed t hat 6 weeks be r eassessed at?. ### Response: appr oximat ely 6 weeks.


Instruction: What should not be continued aut omatically f or long periods of time?

Output: contr ol drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not be continued aut omatically f or long periods of time?. ### Response: contr ol drugs.


Instruction: How long is an appr opriat e time point?

Output: 6  weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is an appr opriat e time point?. ### Response: 6  weeks.


Instruction: What is an appr opriat e time point to assess t he person's r ecovery?

Output: 6  weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an appr opriat e time point to assess t he person's r ecovery?. ### Response: 6  weeks.


Instruction: What was not mak e a separat e recommendation?

Output: people wit h pre-existing atrial fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not mak e a separat e recommendation?. ### Response: people wit h pre-existing atrial fibrillation.


Instruction: Why did not mak e a separat e recommendation for people wit h pre-existing atrial fibrillation?

Output: lack of e vidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why did not mak e a separat e recommendation for people wit h pre-existing atrial fibrillation?. ### Response: lack of e vidence.


Instruction: Did most people under going mitral v alve surgery would under go left atrial surgery?

Output: most people under going mitral v alve sur gery wit h pre-existing atrial fibrillation w ould

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Did most people under going mitral v alve surgery would under go left atrial surgery?. ### Response: most people under going mitral v alve sur gery wit h pre-existing atrial fibrillation w ould.


Instruction: Pre-existing atrial fibrillation w ould under go left atrial surgery to treat what?

Output: atrial fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Pre-existing atrial fibrillation w ould under go left atrial surgery to treat what?. ### Response: atrial fibrillation.


Instruction: How the r ecommenda tions mig ht affect practice?

Output: t hat t he evidence no longer suppor ted the str onger r ecommendation included in t he 2014  guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How the r ecommenda tions mig ht affect practice?. ### Response: t hat t he evidence no longer suppor ted the str onger r ecommendation included in t he 2014  guideline.


Instruction: What is curr ent practice and amiodar?

Output: ic surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is curr ent practice and amiodar?. ### Response: ic surgery.


Instruction: What is curr ent practice and amiodar one is most commonly used?

Output: ic surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is curr ent practice and amiodar one is most commonly used?. ### Response: ic surgery.


Instruction: What can still be considereded?

Output: ic surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can still be considereded?. ### Response: ic surgery.


Instruction: Atrial fibrillation: diagnosis and management (NG196) NICE 2022.

Output: All right s reserved

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atrial fibrillation: diagnosis and management (NG196) NICE 2022.. ### Response: All right s reserved.


Instruction: All right s reserved.

Output: Subject t o Notice of right s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: All right s reserved.. ### Response: Subject t o Notice of right s.


Instruction: What is the last updat ed 30 June 2021?

Output: Page 42of 47

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the last updat ed 30 June 2021?. ### Response: Page 42of 47.


Instruction: What is the name of the book that treats heart failure chronic heart failure?

Output: NICE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the book that treats heart failure chronic heart failure?. ### Response: NICE.


Instruction: Who is the author of NICE 2018?

Output: 978 -1-4731 -3093 -7 167

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of NICE 2018?. ### Response: 978 -1-4731 -3093 -7 167.


Instruction: What was the IQR of the placebo group?

Output: 397

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the IQR of the placebo group?. ### Response: 397.


Instruction: What is the KCCQ clinical summary score?

Output: 3.6 higher  (IQR 67.7 to 91.6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the KCCQ clinical summary score?. ### Response: 3.6 higher  (IQR 67.7 to 91.6.


Instruction: Why is LOW a,d?

Output: risk of bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is LOW a,d?. ### Response: risk of bias.


Instruction: What was the median IQR in the placebo group?

Output: 397

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the median IQR in the placebo group?. ### Response: 397.


Instruction: How much higher was the median KCCQ clinical summary score in the oral iron group?

Output: 3.6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much higher was the median KCCQ clinical summary score in the oral iron group?. ### Response: 3.6.


Instruction: How many increments were downgraded if the majority of the evidence was at high risk of bias?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many increments were downgraded if the majority of the evidence was at high risk of bias?. ### Response: 2.


Instruction: At high risk of bias, and downgraded by 2 increments if the majority of the evidence was at what risk?

Output: very  high risk of bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: At high risk of bias, and downgraded by 2 increments if the majority of the evidence was at what risk?. ### Response: very  high risk of bias.


Instruction: By 1 increment if a confidence interval crossed 1 MID or by how many increments when the confidence interv al crossed both MIDs?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: By 1 increment if a confidence interval crossed 1 MID or by how many increments when the confidence interv al crossed both MIDs?. ### Response: 2.


Instruction: How many increments if the confidence interv al crossed both MIDs?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many increments if the confidence interv al crossed both MIDs?. ### Response: 2.


Instruction: Why was the study downgraded by 1 increment?

Output: heterogeneity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the study downgraded by 1 increment?. ### Response: heterogeneity.


Instruction: What did the study report the results as?

Output: median and IQR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the study report the results as?. ### Response: median and IQR.


Instruction: How much was I2=51%?

Output: Downgraded by 1 increment due to heterogeneity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much was I2=51%?. ### Response: Downgraded by 1 increment due to heterogeneity.


Instruction: Why is I2=51%?

Output: heterogeneity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is I2=51%?. ### Response: heterogeneity.


Instruction: What percentage increment is due to heterogeneity?

Output: 51%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage increment is due to heterogeneity?. ### Response: 51%..


Instruction: How many participants did the study have?

Output: 225

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many participants did the study have?. ### Response: 225.


Instruction: What is the 95% CI of Anticipated absolute effects Risk with Oral iron Risk difference with Intravenous iron?

Output: Relative effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 95% CI of Anticipated absolute effects Risk with Oral iron Risk difference with Intravenous iron?. ### Response: Relative effect.


Instruction: Mortality 17 (1 study) 3 months  VERY LOWa, b due to risk of bias, imprecision Peto Odds Ratio 6.13 (0.33 to 112.36)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Mortality 17 (1 study) 3 months  VERY LOWa, b due to risk of bias, imprecision Peto Odds Ratio 6.13 (0.33 to 112.36). ### Response: ⊕⊝⊝⊝.


Instruction: What is the imprecision Peto Odds Ratio?

Output: 6.13

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the imprecision Peto Odds Ratio?. ### Response: 6.13.


Instruction: How many comparisons of CABG and contemporary medicaltherapy are of sufficient size to allow meaningful conclusions?

Output: Few

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many comparisons of CABG and contemporary medicaltherapy are of sufficient size to allow meaningful conclusions?. ### Response: Few.


Instruction: What was the largest such trial?

Output: BARI2D

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the largest such trial?. ### Response: BARI2D.


Instruction: How many patients with type 2 diabetesmellitus were randomly assigned to revascularization plus intensive medical therapy?

Output: 2368

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with type 2 diabetesmellitus were randomly assigned to revascularization plus intensive medical therapy?. ### Response: 2368.


Instruction: How many patients underwent revascularization during follow-up?

Output: 404,1176

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients underwent revascularization during follow-up?. ### Response: 404,1176.


Instruction: What was determined before randomization by the treating physicians?

Output: The planned method of revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was determined before randomization by the treating physicians?. ### Response: The planned method of revascularization.


Instruction: What was not evident between the PCI group and the themedical therapy group?

Output: primaryendpoints

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not evident between the PCI group and the themedical therapy group?. ### Response: primaryendpoints.


Instruction: What was there no difference in between those undergoing CABG and those receiving only medicaltherapy?

Output: survival rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was there no difference in between those undergoing CABG and those receiving only medicaltherapy?. ### Response: survival rate.


Instruction: Acute MI occurred less often in those assigned to what type of therapy?

Output: CABG plus intensive medical therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Acute MI occurred less often in those assigned to what type of therapy?. ### Response: CABG plus intensive medical therapy.


Instruction: What percentage of patients were assigned to CABG plus intensive medical therapy?

Output: 10%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients were assigned to CABG plus intensive medical therapy?. ### Response: 10%.


Instruction: When was the ACCF/AHA CABG Guideline e695Downloaded from http://ahajournals.org?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the ACCF/AHA CABG Guideline e695Downloaded from http://ahajournals.org?. ### Response: 2011.


Instruction: What is the name of the study that focused on atrial fibrillation?

Output: January et al 2019 Focused Update

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that focused on atrial fibrillation?. ### Response: January et al 2019 Focused Update.


Instruction: When was the Focused Update on Atrial Fibrillation published?

Output: July 9, 2019

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Focused Update on Atrial Fibrillation published?. ### Response: July 9, 2019.


Instruction: How many patients were enrolled in the 3 clinical trials?

Output: both patients with stable ischemic disease and patients with ACS treated with PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were enrolled in the 3 clinical trials?. ### Response: both patients with stable ischemic disease and patients with ACS treated with PCI.


Instruction: How many clinical tri-als enrolled patients with stable ischemic disease and patients with ACS treated with PCI?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many clinical tri-als enrolled patients with stable ischemic disease and patients with ACS treated with PCI?. ### Response: 3.


Instruction: What did not include patients with managed medically?

Output: These trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did not include patients with managed medically?. ### Response: These trials.


Instruction: Warfarin, rivaroxa-ban and dabigatran are options for what?

Output: anticoagulants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Warfarin, rivaroxa-ban and dabigatran are options for what?. ### Response: anticoagulants.


Instruction: What are the names of the drugs used to treat thromboembolism?

Output: warfarin, rivaroxa-ban, and dabigatran

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the drugs used to treat thromboembolism?. ### Response: warfarin, rivaroxa-ban, and dabigatran.


Instruction: How many studies have used the CHA2DS2-VASc score?

Output: several small studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies have used the CHA2DS2-VASc score?. ### Response: several small studies.


Instruction: What is a single-center prospective cohort study?

Output: S7.4-22,S7.4-234

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a single-center prospective cohort study?. ### Response: S7.4-22,S7.4-234.


Instruction: What type of thromboembolism was found in a single-center prospective cohort study?

Output: systemic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of thromboembolism was found in a single-center prospective cohort study?. ### Response: systemic.


Instruction: What was a higher incidence of Thrombolysis in Myocardial Infarction major or minor bleed-ing events?

Output: triple therapy with clopi-dogrel, triple therapy with prasugrel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a higher incidence of Thrombolysis in Myocardial Infarction major or minor bleed-ing events?. ### Response: triple therapy with clopi-dogrel, triple therapy with prasugrel.


Instruction: What was the name of the TRANSLATE-ACS study?

Output: Treatment with Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the TRANSLATE-ACS study?. ### Response: Treatment with Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome.


Instruction: What type of study did TRANSLate-ACS do?

Output: Treatment with Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of study did TRANSLate-ACS do?. ### Response: Treatment with Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome.


Instruction: How did the Translate ACS study compare to triple therapy?

Output: did not include patients with ACS managed medically

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did the Translate ACS study compare to triple therapy?. ### Response: did not include patients with ACS managed medically.


Instruction: What is BARC?

Output: Bleeding Academic Research Consortium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is BARC?. ### Response: Bleeding Academic Research Consortium.


Instruction: What was an RCT that showed that triple therapy with prasugrel was associated with a higher incidence of bleed-ing events?

Output: WOEST

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was an RCT that showed that triple therapy with prasugrel was associated with a higher incidence of bleed-ing events?. ### Response: WOEST.


Instruction: What did an RCT show was associated with fewer bleeding complications?

Output: double therapy with warfarin and clopidogrel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did an RCT show was associated with fewer bleeding complications?. ### Response: double therapy with warfarin and clopidogrel.


Instruction: What was not powered to assess stent thrombosis?

Output: WOEST

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not powered to assess stent thrombosis?. ### Response: WOEST.


Instruction: How did two other registry-based studies show that double therapy with warfarin and clopidogrel was not?

Output: These trials did not include patients with ACS managed medically

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did two other registry-based studies show that double therapy with warfarin and clopidogrel was not?. ### Response: These trials did not include patients with ACS managed medically.


Instruction: Dou-ble therapy with warfarin and clopidogrel was not associated with higher risk of what?

Output: coronary isch-emia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Dou-ble therapy with warfarin and clopidogrel was not associated with higher risk of what?. ### Response: coronary isch-emia.


Instruction: What did a hospital-based retrospective cohort study find?

Output: double therapy with warfarin and ticagrelor had thrombotic and bleeding rates that were similar to those observed with triple therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a hospital-based retrospective cohort study find?. ### Response: double therapy with warfarin and ticagrelor had thrombotic and bleeding rates that were similar to those observed with triple therapy.


Instruction: How many patients were in the PIONEER AF-PCI trial?

Output: 2 124

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were in the PIONEER AF-PCI trial?. ### Response: 2 124.


Instruction: What was the name of the multi-center, randomized, open-label trial of 2 124 patients with AF?

Output: PIONEER AF-PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the multi-center, randomized, open-label trial of 2 124 patients with AF?. ### Response: PIONEER AF-PCI.


Instruction: How many patients had AF without mitral stenosis or a mechanical heart valve?

Output: 2 124

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had AF without mitral stenosis or a mechanical heart valve?. ### Response: 2 124.


Instruction: How were patients randomized?

Output: 1:1:1 ratio to low-dose rivar -oxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How were patients randomized?. ### Response: 1:1:1 ratio to low-dose rivar -oxaban.


Instruction: What was the ratio of patients to low-dose rivar -oxaban?

Output: 1:1:1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the ratio of patients to low-dose rivar -oxaban?. ### Response: 1:1:1.


Instruction: Who published the 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease?

Output: Arnett et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease?. ### Response: Arnett et al.


Instruction: What are the most widely used measurements in clinical practice?

Output: S4.1-18 BMI, waist circumference, and waist–hip ratio

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the most widely used measurements in clinical practice?. ### Response: S4.1-18 BMI, waist circumference, and waist–hip ratio.


Instruction: What is the most widely used in clinical practice?

Output: S4.1-18 BMI, waist circumference, and waist–hip ratio

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most widely used in clinical practice?. ### Response: S4.1-18 BMI, waist circumference, and waist–hip ratio.


Instruction: A USPSTF document found good evi-dence supporting the use of BMI to identify adults at increased risk of future morbidity and mortality?

Output: S4.1-18

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A USPSTF document found good evi-dence supporting the use of BMI to identify adults at increased risk of future morbidity and mortality?. ### Response: S4.1-18.


Instruction: What should BMI be inter -preted with caution in persons of Asian ancestry, older adults, and muscular adults?

Output: S4.1-18

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should BMI be inter -preted with caution in persons of Asian ancestry, older adults, and muscular adults?. ### Response: S4.1-18.


Instruction: What has been associ-ated with increased cardiometabolic and ASCVD risk?

Output: Increased waist circumference

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been associ-ated with increased cardiometabolic and ASCVD risk?. ### Response: Increased waist circumference.


Instruction: What has been associated with ASCVD risk?

Output: Central adiposity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been associated with ASCVD risk?. ### Response: Central adiposity.


Instruction: What measurement is recommended in all patients with BMI 35 kg/m2?

Output: Waist cir -cumference measurement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What measurement is recommended in all patients with BMI 35 kg/m2?. ### Response: Waist cir -cumference measurement.


Instruction: How is central adiposity captured?

Output: by using waist circumference

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is central adiposity captured?. ### Response: by using waist circumference.


Instruction: What is the BMI of all patients with BMI 35 kg/m2?

Output: Waist cir -cumference measurement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the BMI of all patients with BMI 35 kg/m2?. ### Response: Waist cir -cumference measurement.


Instruction: Ethnic differences in waist circumference thresholds associated with cardiometabolic risk have been reported?

Output: ≥40 inches (≥102 cm) in men and ≥35 inches (≥88 cm) in women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Ethnic differences in waist circumference thresholds associated with cardiometabolic risk have been reported?. ### Response: ≥40 inches (≥102 cm) in men and ≥35 inches (≥88 cm) in women.


Instruction: Waist circumference may be more useful than what in persons with abdominal obesity?

Output: BMI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Waist circumference may be more useful than what in persons with abdominal obesity?. ### Response: BMI.


Instruction: What are the definitions of elevated waist circumference in men?

Output: ≥40 inches (≥102 cm)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the definitions of elevated waist circumference in men?. ### Response: ≥40 inches (≥102 cm).


Instruction: What was recommended by the 1998 National Heart, Lung and Blood Institute Obesity Initiative Expert PanelS4.1-25?

Output: Definitions of elevated waist cir -cumference

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was recommended by the 1998 National Heart, Lung and Blood Institute Obesity Initiative Expert PanelS4.1-25?. ### Response: Definitions of elevated waist cir -cumference.


Instruction: What was adopted by the 2013 AHA/ACC/TOS writing committee?

Output: Definitions of elevated waist cir -cumference

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was adopted by the 2013 AHA/ACC/TOS writing committee?. ### Response: Definitions of elevated waist cir -cumference.


Instruction: What is needed for the diagnosis of metabolic syndrome?

Output: waist circumference assessment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed for the diagnosis of metabolic syndrome?. ### Response: waist circumference assessment.


Instruction: What may be the best approach for assessing obesity-related risk?

Output: combining waist circumference and BMI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be the best approach for assessing obesity-related risk?. ### Response: combining waist circumference and BMI.


Instruction: Counseling and comprehensive lifestyle interventions have all been associated with what?

Output: significant reductions in waist circumference and improvement in cardiometabolic risk profiles

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Counseling and comprehensive lifestyle interventions have all been associated with what?. ### Response: significant reductions in waist circumference and improvement in cardiometabolic risk profiles.


Instruction: What has surgery been associated with?

Output: significant reductions in waist circumference and improvement in cardiometabolic risk profiles

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has surgery been associated with?. ### Response: significant reductions in waist circumference and improvement in cardiometabolic risk profiles.


Instruction: What have all been linked with significant reductions in waist circumference?

Output: restriction and adjunctive therapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have all been linked with significant reductions in waist circumference?. ### Response: restriction and adjunctive therapies.


Instruction: What is the name of the supplement that summarizes studies that support recommendations?

Output: Online Data Supplement 10.COR LOE RecommendationsI A1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the supplement that summarizes studies that support recommendations?. ### Response: Online Data Supplement 10.COR LOE RecommendationsI A1.


Instruction: What type of diet is recommended for adults with T2DM?

Output: heart-healthy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diet is recommended for adults with T2DM?. ### Response: heart-healthy.


Instruction: A tailored nutrition plan focusing on a heart-healthy dietary pattern is recommended?

Output: For all adults with T2DM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A tailored nutrition plan focusing on a heart-healthy dietary pattern is recommended?. ### Response: For all adults with T2DM.


Instruction: What should adults with T2DM perform at least 150 minutes of per week of moderate-intensity physical activity?

Output: e596–e646

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should adults with T2DM perform at least 150 minutes of per week of moderate-intensity physical activity?. ### Response: e596–e646.


Instruction: What is the loading dose ofticagrelorLD?

Output: 180 mg orally

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the loading dose ofticagrelorLD?. ### Response: 180 mg orally.


Instruction: What should patients who are already taking clopidogrel take?

Output: a loading dose ofticagrelorLD of 180 mg orally

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients who are already taking clopidogrel take?. ### Response: a loading dose ofticagrelorLD of 180 mg orally.


Instruction: Who should take 90 mg orally twice daily?

Output: Patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should take 90 mg orally twice daily?. ### Response: Patients.


Instruction: What is the recommended maintenance dose of ASA to be used with ticagrelor?

Output: 81 mg daily

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommended maintenance dose of ASA to be used with ticagrelor?. ### Response: 81 mg daily.


Instruction: What percentage of patients in PLATOreceived clopidogrel at the time of randomization?

Output: 47%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients in PLATOreceived clopidogrel at the time of randomization?. ### Response: 47%.


Instruction: What should be at least 5d before surgery?

Output: Period of withdrawal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be at least 5d before surgery?. ### Response: Period of withdrawal.


Instruction: What increases the risk of fatal ICH compared with clopidogrel?

Output: Ticagrelor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What increases the risk of fatal ICH compared with clopidogrel?. ### Response: Ticagrelor.


Instruction: Who should be avoided in those with prior history of ICH?

Output: Ticagrelor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should be avoided in those with prior history of ICH?. ### Response: Ticagrelor.


Instruction: What should be considered when considering the addition ofticagrelor to aspirin in patients with prior stroke or TIA?

Output: intracranial bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered when considering the addition ofticagrelor to aspirin in patients with prior stroke or TIA?. ### Response: intracranial bleeding.


Instruction: When was this publication circulated?

Output: August 14, 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this publication circulated?. ### Response: August 14, 2012.


Instruction: How are patients treated with PCI brought to cardiac catheterization after being resuscitated from out-of-hospital cardiac arrest?

Output: separately from their hospital and individual operator quality “score-cards

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are patients treated with PCI brought to cardiac catheterization after being resuscitated from out-of-hospital cardiac arrest?. ### Response: separately from their hospital and individual operator quality “score-cards.


Instruction: What is the percentage of cardiac arrest vic-tims whose event is triggered by an acute coronary occlusion less clear?

Output: 77,197,198

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the percentage of cardiac arrest vic-tims whose event is triggered by an acute coronary occlusion less clear?. ### Response: 77,197,198.


Instruction: What is present in the majority of cardiac arrest victims who survive and undergo coronary angiography?

Output: Coronary atherosclerosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is present in the majority of cardiac arrest victims who survive and undergo coronary angiography?. ### Response: Coronary atherosclerosis.


Instruction: What is the high prevalence of in out-of-hospital cardiac arrest patients who cannot be resuscitated?

Output: mortality rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the high prevalence of in out-of-hospital cardiac arrest patients who cannot be resuscitated?. ### Response: mortality rate.


Instruction: What does the AHA 2010 Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care201 recommend?

Output: emer -gency coronary angiography with prompt opening of the infarct artery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the AHA 2010 Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care201 recommend?. ### Response: emer -gency coronary angiography with prompt opening of the infarct artery.


Instruction: What does emer -gency coronary angiography with prompt opening of the infarct artery do?

Output: occlusions in out-of-hospital cardiac arrest patients who are resuscitated successfully

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does emer -gency coronary angiography with prompt opening of the infarct artery do?. ### Response: occlusions in out-of-hospital cardiac arrest patients who are resuscitated successfully.


Instruction: What is angiography with prompt opening of the infarct artery?

Output: emer -gency coronary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is angiography with prompt opening of the infarct artery?. ### Response: emer -gency coronary.


Instruction: What is the rate of survival to discharge after early PCI?

Output: 60%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the rate of survival to discharge after early PCI?. ### Response: 60%.


Instruction: Who issued a policy statement calling for communi-ties to establish regional systems of care for out-of-hospital cardiac arrest victims?

Output: The AHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who issued a policy statement calling for communi-ties to establish regional systems of care for out-of-hospital cardiac arrest victims?. ### Response: The AHA.


Instruction: How many different levels of cardiac resuscitation centers are defined in the statement?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many different levels of cardiac resuscitation centers are defined in the statement?. ### Response: 2.


Instruction: What are ideal can-didates to serve as Level I cardiac reassur-tion centers?

Output: PCI-capable hospitals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are ideal can-didates to serve as Level I cardiac reassur-tion centers?. ### Response: PCI-capable hospitals.


Instruction: What type of resuscitation center can offer a wide range of services?

Output: Level I

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of resuscitation center can offer a wide range of services?. ### Response: Level I.


Instruction: What should all other partici-pating hospitals be trained and equipped as?

Output: Level II cardiac resuscitation centers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should all other partici-pating hospitals be trained and equipped as?. ### Response: Level II cardiac resuscitation centers.


Instruction: What should hospitals be trained and equipped as?

Output: Level II cardiac resuscitation centers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should hospitals be trained and equipped as?. ### Response: Level II cardiac resuscitation centers.


Instruction: What are Level II cardiac resuscitation centers capable of initiating?

Output: therapeutic hypothermia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are Level II cardiac resuscitation centers capable of initiating?. ### Response: therapeutic hypothermia.


Instruction: Out-of-hospital cardiac arrest outcomes should be measured and compared within what?

Output: dedi-cated registry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Out-of-hospital cardiac arrest outcomes should be measured and compared within what?. ### Response: dedi-cated registry.


Instruction: What is important for organizations that collect and publicly report STEMI and PCI data to consider separately from their hospital and individual operator quality score-cards?

Output: resuscitated out-of-hospital cardiac arrest patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is important for organizations that collect and publicly report STEMI and PCI data to consider separately from their hospital and individual operator quality score-cards?. ### Response: resuscitated out-of-hospital cardiac arrest patients.


Instruction: Patients with STEMI have a much higher mortality rate than patients with what?

Output: optimal care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with STEMI have a much higher mortality rate than patients with what?. ### Response: optimal care.


Instruction: What is the mortality rate of STEMI patients?

Output: not had a cardiac arrest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the mortality rate of STEMI patients?. ### Response: not had a cardiac arrest.


Instruction: What might public reporting have the unintended consequence of reducing appropriate care?

Output: resuscitation centers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What might public reporting have the unintended consequence of reducing appropriate care?. ### Response: resuscitation centers.


Instruction: Primary PCI in STEMI: Recommendations

Output: PCI-Capable Hospital

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Primary PCI in STEMI: Recommendations. ### Response: PCI-Capable Hospital.


Instruction: What should be performed in patients with STEMI and ischemic symptoms of less than 12 hours' duration?

Output: Primary PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be performed in patients with STEMI and ischemic symptoms of less than 12 hours' duration?. ### Response: Primary PCI.


Instruction: What is the level of evidence for Primary PCI?

Output: A

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the level of evidence for Primary PCI?. ### Response: A.


Instruction: What is the difference between primary angioplasty and thrombolysis?

Output: obesity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between primary angioplasty and thrombolysis?. ### Response: obesity.


Instruction: When did the J Am Coll Cardiol. 1999:33:412-9?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the J Am Coll Cardiol. 1999:33:412-9?. ### Response: 1999.


Instruction: What was the GUSTO-I trial about?

Output: Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the GUSTO-I trial about?. ### Response: Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries.


Instruction: What is a high prevalence of subclinical coronary atherosclerosis in women with a low Framingham risk score and a family history of premature coronary heart disease?

Output: 119

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a high prevalence of subclinical coronary atherosclerosis in women with a low Framingham risk score and a family history of premature coronary heart disease?. ### Response: 119.


Instruction: What is the name of the study that examined cardiac events in patients with acute coronary syndrome at a com-munity hospital?

Output: GUSTO-I trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined cardiac events in patients with acute coronary syndrome at a com-munity hospital?. ### Response: GUSTO-I trial.


Instruction: How long did it take for cardiac events to occur in a 30-day period?

Output: 120

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for cardiac events to occur in a 30-day period?. ### Response: 120.


Instruction: What is a family history of premature coronary heart disease?

Output: high prevalence of subclinical coronary atherosclerosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a family history of premature coronary heart disease?. ### Response: high prevalence of subclinical coronary atherosclerosis.


Instruction: What is more strongly associated with sibling history than parental history of premature coronary heart disease?

Output: sibling history

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more strongly associated with sibling history than parental history of premature coronary heart disease?. ### Response: sibling history.


Instruction: Circulation. 2004;110:2150–6. What is the influence of diabetes mel-litus on clinical outcome in the thrombolytic era of acute myocardial infarction?

Output: 122. Mak KH, Moliterno DJ, Granger CB, et al. Influence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation. 2004;110:2150–6. What is the influence of diabetes mel-litus on clinical outcome in the thrombolytic era of acute myocardial infarction?. ### Response: 122. Mak KH, Moliterno DJ, Granger CB, et al. Influence.


Instruction: What is the era of acute myocardial infarction?

Output: thrombolytic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the era of acute myocardial infarction?. ### Response: thrombolytic.


Instruction: Who is the GUSTO-I Investigators?

Output: Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the GUSTO-I Investigators?. ### Response: Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries.


Instruction: What is Streptokinase and Tissue Plasminogen Activator for?

Output: Occluded Coronary Arteries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Streptokinase and Tissue Plasminogen Activator for?. ### Response: Occluded Coronary Arteries.


Instruction: When was J Am Coll Cardiol 30:171-9?

Output: 1997

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was J Am Coll Cardiol 30:171-9?. ### Response: 1997.


Instruction: What are the outcomes in patients with acute ST-elevation myocardial infarction?

Output: clinical outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the outcomes in patients with acute ST-elevation myocardial infarction?. ### Response: clinical outcomes.


Instruction: What is excess weight at time of presentation associated with?

Output: lower initial mortality risks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is excess weight at time of presentation associated with?. ### Response: lower initial mortality risks.


Instruction: Is excess weight associated with lower initial mortality risks or higher long term risks?

Output: higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Is excess weight associated with lower initial mortality risks or higher long term risks?. ### Response: higher.


Instruction: What are some of the risks associated with recurrent re-infarction and car-diac death?

Output: higher long-term risks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the risks associated with recurrent re-infarction and car-diac death?. ### Response: higher long-term risks.


Instruction: What is the name of the study that found the obesity paradox in non-ST-segment elevation acute coronary syndromes?

Output: Can Rapid risk stratification of Unstable angina patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that found the obesity paradox in non-ST-segment elevation acute coronary syndromes?. ### Response: Can Rapid risk stratification of Unstable angina patients.


Instruction: What does the American College of Cardiology/American Heart Association Guidelines Quality Improvement Initiative do?

Output: Early implementation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the American College of Cardiology/American Heart Association Guidelines Quality Improvement Initiative do?. ### Response: Early implementation.


Instruction: What does obesity have to do with coronary artery disease?

Output: severity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does obesity have to do with coronary artery disease?. ### Response: severity.


Instruction: What is the name of the disease in patients undergoing coronary angi-ography?

Output: coronary artery disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease in patients undergoing coronary angi-ography?. ### Response: coronary artery disease.


Instruction: What are the names of the diseases in Korean men and women?

Output: Overweight, obesity, and mor -tality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the diseases in Korean men and women?. ### Response: Overweight, obesity, and mor -tality.


Instruction: How is the body-mass index and mortality measured?

Output: 779–87

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the body-mass index and mortality measured?. ### Response: 779–87.


Instruction: What is the age range of people 50 to 71 years old in a large prospective cohort of?

Output: 128

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the age range of people 50 to 71 years old in a large prospective cohort of?. ### Response: 128.


Instruction: What was the N Engl J Med. 2006;355:763–78?

Output: Overweight, obesity, and mor -tality in a large prospective cohort of persons 50 to 71 years old

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the N Engl J Med. 2006;355:763–78?. ### Response: Overweight, obesity, and mor -tality in a large prospective cohort of persons 50 to 71 years old.


Instruction: What is the name of the systematic review of cohort studies?

Output: Lancet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review of cohort studies?. ### Response: Lancet.


Instruction: When was the Lancet 368: 666–78 published?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Lancet 368: 666–78 published?. ### Response: 2006.


Instruction: What is a trigger for myocardial infarction?

Output: Excess weight

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a trigger for myocardial infarction?. ### Response: Excess weight.


Instruction: What percentage of deaths were reduced with monotherapy RASi compared to dualRASi therapy?

Output: 9%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of deaths were reduced with monotherapy RASi compared to dualRASi therapy?. ### Response: 9%.


Instruction: How long was the mean follow-up of the patients with dualRASi?

Output: 52 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the mean follow-up of the patients with dualRASi?. ### Response: 52 months.


Instruction: What was the marginal reduction of 20% in serum creatinine by dual therapy versus monotherapy?

Output: doubling

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the marginal reduction of 20% in serum creatinine by dual therapy versus monotherapy?. ### Response: doubling.


Instruction: How long did the study last?

Output: 37 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the study last?. ### Response: 37 months.


Instruction: What was the mean follow-up of the study?

Output: 37 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean follow-up of the study?. ### Response: 37 months.


Instruction: The lower con fidence interval reaches what?

Output: thenull

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The lower con fidence interval reaches what?. ### Response: thenull.


Instruction: What does dual therapy reduce albuminuria and BP compared to monotherapy?

Output: moderately

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does dual therapy reduce albuminuria and BP compared to monotherapy?. ### Response: moderately.


Instruction: What causes more hyperkalemia?

Output: dual therapydoes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes more hyperkalemia?. ### Response: dual therapydoes.


Instruction: What causes more hyperkalemia and AKI?

Output: dual therapydoes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes more hyperkalemia and AKI?. ### Response: dual therapydoes.


Instruction: What was the overall quality of the evidence forharm?

Output: moderate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the overall quality of the evidence forharm?. ### Response: moderate.


Instruction: Why was the network meta-analysis moderate?

Output: concerns regarding inconsistency for all-cause mortality and CV events and serious imprecision forESKD due to wide CIs that indicated appreciable bene ﬁtsand harms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the network meta-analysis moderate?. ### Response: concerns regarding inconsistency for all-cause mortality and CV events and serious imprecision forESKD due to wide CIs that indicated appreciable bene ﬁtsand harms.


Instruction: Inconsistency for all-cause mortality and CV events and serious imprecision forESKD due to wide CIs that indicated appreciable bene fitsand what?

Output: harms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Inconsistency for all-cause mortality and CV events and serious imprecision forESKD due to wide CIs that indicated appreciable bene fitsand what?. ### Response: harms.


Instruction: The ERT review rated the quality of evidence to be what for studies that compared dual with mono RASi?

Output: moderate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The ERT review rated the quality of evidence to be what for studies that compared dual with mono RASi?. ### Response: moderate.


Instruction: What was the quality of the evidence for most outcomes?

Output: moderate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the quality of the evidence for most outcomes?. ### Response: moderate.


Instruction: What was unclear reporting for for Cochrane risk of bias282domains?

Output: random sequence generation, and allocation concealment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was unclear reporting for for Cochrane risk of bias282domains?. ### Response: random sequence generation, and allocation concealment.


Instruction: What was downgraded because of serious imprecision?

Output: the quality of the evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was downgraded because of serious imprecision?. ### Response: the quality of the evidence.


Instruction: How many studies reported all-cause mortality?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies reported all-cause mortality?. ### Response: 1.


Instruction: What was downgraded due to wide con fidence intervals that indicate appreciable bene fitsand harms?

Output: all-cause mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was downgraded due to wide con fidence intervals that indicate appreciable bene fitsand harms?. ### Response: all-cause mortality.


Instruction: What was the quality of the evidence downgraded to for serious adverse events?

Output: moderate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the quality of the evidence downgraded to for serious adverse events?. ### Response: moderate.


Instruction: What does the Work Group believe is more important than preventinghyperkalemia and AKI?

Output: reduction ofalbuminuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Work Group believe is more important than preventinghyperkalemia and AKI?. ### Response: reduction ofalbuminuria.


Instruction: What is unclear in view of the absence of effects in the reduction ofalbuminuria?

Output: The signi ﬁcance of these bene ﬁcial effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is unclear in view of the absence of effects in the reduction ofalbuminuria?. ### Response: The signi ﬁcance of these bene ﬁcial effects.


Instruction: The Work Group believes that this recommendation places a higher importance on what?

Output: preventinghyperkalemia and AKI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The Work Group believes that this recommendation places a higher importance on what?. ### Response: preventinghyperkalemia and AKI.


Instruction: What is unclear in view of the absence of effects in GFR during the follow-up period of the trials?

Output: The signi ﬁcance of these bene ﬁcial effects onalbuminuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is unclear in view of the absence of effects in GFR during the follow-up period of the trials?. ### Response: The signi ﬁcance of these bene ﬁcial effects onalbuminuria.


Instruction: What has been found for dual therapy in HF?

Output: somebeneﬁt

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been found for dual therapy in HF?. ### Response: somebeneﬁt.


Instruction: What year was Chronic Heart Failure Referral and approach to care published by NICE?

Output: 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was Chronic Heart Failure Referral and approach to care published by NICE?. ### Response: 2018.


Instruction: Where was the author from?

Output: Highlands of Scotland

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where was the author from?. ### Response: Highlands of Scotland.


Instruction: How many different trusts were involved in the study?

Output: three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many different trusts were involved in the study?. ### Response: three.


Instruction: Adequacy was rated as what?

Output: no or very minor concerns

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Adequacy was rated as what?. ### Response: no or very minor concerns.


Instruction: What was expected in the subfinding?

Output: fairly general

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was expected in the subfinding?. ### Response: fairly general.


Instruction: How was the subfinding supported?

Output: numbers of studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the subfinding supported?. ### Response: numbers of studies.


Instruction: What was the overall assessment of confidence?

Output: moderate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the overall assessment of confidence?. ### Response: moderate.


Instruction: Why was the confidence downgraded?

Output: combined minor concerns about methodology, coherence and relevance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the confidence downgraded?. ### Response: combined minor concerns about methodology, coherence and relevance.


Instruction: What concerns did increment have about methodology, coherence and relevance?

Output: Methodological limitations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What concerns did increment have about methodology, coherence and relevance?. ### Response: Methodological limitations.


Instruction: What did people discharged from HF clinics to primary care report having gone from?

Output: a situation where they received appointments for follow -up

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did people discharged from HF clinics to primary care report having gone from?. ### Response: a situation where they received appointments for follow -up.


Instruction: What did some feel like they were no longer eligible for?

Output: help

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did some feel like they were no longer eligible for?. ### Response: help.


Instruction: What did they express a wish to be called to see?

Output: the GP or nurse

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did they express a wish to be called to see?. ### Response: the GP or nurse.


Instruction: Who expressed a wish to be called to see the GP or nurse once in a while?

Output: One patient

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who expressed a wish to be called to see the GP or nurse once in a while?. ### Response: One patient.


Instruction: What did one patient feel?

Output: a bit left out

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did one patient feel?. ### Response: a bit left out.


Instruction: What did HF nurses say led to unhappiness when discharging patients?

Output: people liked being pat ients in the HF clinic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did HF nurses say led to unhappiness when discharging patients?. ### Response: people liked being pat ients in the HF clinic.


Instruction: What type of clinics do nurses see patients discharged from?

Output: HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of clinics do nurses see patients discharged from?. ### Response: HF.


Instruction: What do patients who get discharged hate?

Output: HF clinics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do patients who get discharged hate?. ### Response: HF clinics.


Instruction: What does the focussed qualitative review on on continuity in care focus on?

Output: Feelings of abandonment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the focussed qualitative review on on continuity in care focus on?. ### Response: Feelings of abandonment.


Instruction: What did the focussed qualitative review on continuity in CG138 find?

Output: Feelings of abandonment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the focussed qualitative review on continuity in CG138 find?. ### Response: Feelings of abandonment.


Instruction: What was the sub -finding based on?

Output: 2 studies 14, 294

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the sub -finding based on?. ### Response: 2 studies 14, 294.


Instruction: How many studies were based on this sub-finding?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were based on this sub-finding?. ### Response: 2.


Instruction: How many papers were rated serious?

Output: Two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many papers were rated serious?. ### Response: Two.


Instruction: What was the study of patient interviews because of?

Output: limited discussion and reflection on the role of the researc her and their methods

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the study of patient interviews because of?. ### Response: limited discussion and reflection on the role of the researc her and their methods.


Instruction: How was the study of HCP interviews rated?

Output: moderate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the study of HCP interviews rated?. ### Response: moderate.


Instruction: What was rated no or very minor?

Output: Adequacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was rated no or very minor?. ### Response: Adequacy.


Instruction: What was rated as no or very minor concerns overall?

Output: Adequacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was rated as no or very minor concerns overall?. ### Response: Adequacy.


Instruction: What was good about the agreement between papers?

Output: Coherence was rated no or very minor concerns overall. Agreement between papers was good, and while it does not directly align with the sub -finding concerning the primacy of primary care in providing continuity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was good about the agreement between papers?. ### Response: Coherence was rated no or very minor concerns overall. Agreement between papers was good, and while it does not directly align with the sub -finding concerning the primacy of primary care in providing continuity.


Instruction: The lack of continuity within the system as a whole was rated as what?

Output: minor concerns

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The lack of continuity within the system as a whole was rated as what?. ### Response: minor concerns.


Instruction: The relevance of the sub -finding to the focus of the section was what concern?

Output: Relevance was rated minor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The relevance of the sub -finding to the focus of the section was what concern?. ### Response: Relevance was rated minor.


Instruction: What was not powered to examine the risk of ASCVD events?

Output: The study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not powered to examine the risk of ASCVD events?. ### Response: The study.


Instruction: What did a very large placebo-controlled RCT examine in post-ACS patients?

Output: ASCVD outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a very large placebo-controlled RCT examine in post-ACS patients?. ### Response: ASCVD outcomes.


Instruction: How long did the addition of ezetimibe 10 mg to simvastatin 40 years?

Output: 7 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the addition of ezetimibe 10 mg to simvastatin 40 years?. ### Response: 7 years.


Instruction: What did the addition of ezetimibe 10 mg to simvastatin 40 mg daily result in?

Output: greater ASCVD risk reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the addition of ezetimibe 10 mg to simvastatin 40 mg daily result in?. ### Response: greater ASCVD risk reduction.


Instruction: What did statin monotherapy produce?

Output: ≥50% reduction in LDL-C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did statin monotherapy produce?. ### Response: ≥50% reduction in LDL-C.


Instruction: Patients with severe hyper -cholesterolemia exhibit greater ASCVD risk reduction from what?

Output: ezetimibe add-on therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with severe hyper -cholesterolemia exhibit greater ASCVD risk reduction from what?. ### Response: ezetimibe add-on therapy.


Instruction: What are patients with severe hyper cholesterolemia likely to derive additional ASCVD risk reduction from ezetimibe add-on therapy?

Output: LDL-C level ≥100 mg/dL (≥2.6 mmol/L)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients with severe hyper cholesterolemia likely to derive additional ASCVD risk reduction from ezetimibe add-on therapy?. ### Response: LDL-C level ≥100 mg/dL (≥2.6 mmol/L).


Instruction: What does ezetimibe add-on therapy reduce ASCVD risk from?

Output: LDL-C lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ezetimibe add-on therapy reduce ASCVD risk from?. ### Response: LDL-C lowering.


Instruction: What has demonstrated LDL-C-lowering efficacy when administered to patients with severe hyper-cholesterolemia?

Output: bile acid sequestrants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has demonstrated LDL-C-lowering efficacy when administered to patients with severe hyper-cholesterolemia?. ### Response: bile acid sequestrants.


Instruction: What is limited by the lack of ASCVD outcomes data when used in combi-nation with statins?

Output: the clinical utility of bile acid sequestrants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is limited by the lack of ASCVD outcomes data when used in combi-nation with statins?. ### Response: the clinical utility of bile acid sequestrants.


Instruction: What are the issues of twice-daily dosing, high pill burden, the absence of well-tolerated generic formulations, drug inter-actions and potential for triglyceride eleva-tion?

Output: the clinical utility of bile acid sequestrants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the issues of twice-daily dosing, high pill burden, the absence of well-tolerated generic formulations, drug inter-actions and potential for triglyceride eleva-tion?. ### Response: the clinical utility of bile acid sequestrants.


Instruction: What is the potential for triglyceride eleva-tion?

Output: maximal cholesterol-lowering therapy in patients who are not eligible for a PCSK9 inhib-itor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the potential for triglyceride eleva-tion?. ### Response: maximal cholesterol-lowering therapy in patients who are not eligible for a PCSK9 inhib-itor.


Instruction: In patients with very severe hypercholesterolemia, adding sequestrants to otherwise maximal cholesterol-lowering therapy may be considered in patients who are not eligible for what?

Output: PCSK9 inhib-itor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with very severe hypercholesterolemia, adding sequestrants to otherwise maximal cholesterol-lowering therapy may be considered in patients who are not eligible for what?. ### Response: PCSK9 inhib-itor.


Instruction: What are promising drugs for treat-ment of FH?

Output: PCSK9 inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are promising drugs for treat-ment of FH?. ### Response: PCSK9 inhibitors.


Instruction: How old were the patients with heterozygous FH?

Output: ≥18 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old were the patients with heterozygous FH?. ### Response: ≥18 years of age.


Instruction: How much reduction in LDL-C did the two RCTs show?

Output: ≥50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much reduction in LDL-C did the two RCTs show?. ### Response: ≥50%.


Instruction: What is reduced in LDL-C?

Output: ≥50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reduced in LDL-C?. ### Response: ≥50%.


Instruction: There are no cur -rently available outcomes trials of what inhibi-tors in patients with ASCVD heterozygous FH?

Output: PCSK9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There are no cur -rently available outcomes trials of what inhibi-tors in patients with ASCVD heterozygous FH?. ### Response: PCSK9.


Instruction: What is a risk factor for heterozygous FH?

Output: age-related risk would likely apply to those with heterozygous FH because of their higher lifetime exposure to increased LDL-C concentration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for heterozygous FH?. ### Response: age-related risk would likely apply to those with heterozygous FH because of their higher lifetime exposure to increased LDL-C concentration.


Instruction: What is the lifetime exposure to increased LDL-C concentration?

Output: higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the lifetime exposure to increased LDL-C concentration?. ### Response: higher.


Instruction: When was the study completed?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the study completed?. ### Response: April 28, 2023.


Instruction: What does CHEST stand for?

Output: weight-based nomogram

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CHEST stand for?. ### Response: weight-based nomogram.


Instruction: What is the weight-based nomogram?

Output: starting dose, 80 units/kg bolus followed by 18 units/kg/h by infusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the weight-based nomogram?. ### Response: starting dose, 80 units/kg bolus followed by 18 units/kg/h by infusion.


Instruction: How many units of heparin are in a bolus?

Output: 5,000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many units of heparin are in a bolus?. ### Response: 5,000.


Instruction: Who received higher doses within the fi rst 24 h?

Output: Patients whose heparin was weight-adjusted

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who received higher doses within the fi rst 24 h?. ### Response: Patients whose heparin was weight-adjusted.


Instruction: What was significantly lower with the weight-adjusted heparin regimen?

Output: The rate of recurrent thromboem-bolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was significantly lower with the weight-adjusted heparin regimen?. ### Response: The rate of recurrent thromboem-bolism.


Instruction: What is the initial dosing of IV Heparin for VTE either weight-based?

Output: 80 units/kg bolus and 18 units/kg/h infusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the initial dosing of IV Heparin for VTE either weight-based?. ### Response: 80 units/kg bolus and 18 units/kg/h infusion.


Instruction: How many units/kg bolus and 18 units per kg/h infusion?

Output: 80

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many units/kg bolus and 18 units per kg/h infusion?. ### Response: 80.


Instruction: How many units of heparin can be given as a bolus?

Output: 5,000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many units of heparin can be given as a bolus?. ### Response: 5,000.


Instruction: What is the maximum amount of units/d given for treatment of VTE?

Output: 4,000 units

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the maximum amount of units/d given for treatment of VTE?. ### Response: 4,000 units.