Instruction: What is the baseline NIH Stroke Scale score strongly predicts after stroke?

Output: outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the baseline NIH Stroke Scale score strongly predicts after stroke?. ### Response: outcome.


Instruction: What does TOAST stand for?

Output: Trial of Org 10172 in Acute Stroke Treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does TOAST stand for?. ### Response: Trial of Org 10172 in Acute Stroke Treatment.


Instruction: What is the name of the trial of ORG 10172 in Acute Stroke Treatment?

Output: TOAST

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the trial of ORG 10172 in Acute Stroke Treatment?. ### Response: TOAST.


Instruction: Neurology. 1999;53:126–131. doi: 10.212/wnl.53.1.126 72.

Output: 1212

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Neurology. 1999;53:126–131. doi: 10.212/wnl.53.1.126 72.. ### Response: 1212.


Instruction: What is the name of the National Institute of Neurological Disorders and Stroke rt-PA?

Output: NINDS t-PA Stroke Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the National Institute of Neurological Disorders and Stroke rt-PA?. ### Response: NINDS t-PA Stroke Study Group.


Instruction: What is a multivariable variable for the Safe Implementation of Thrombolysis?

Output: outcome predictors and adjustment of main outcome results to baseline data profile

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a multivariable variable for the Safe Implementation of Thrombolysis?. ### Response: outcome predictors and adjustment of main outcome results to baseline data profile.


Instruction: Who is responsible for the safe implementation of thrombolysis in stroke-MOnitoring STUDy Investigators?

Output: Wahlgren N, Ahmed N, Eriksson N, Aichner F, Bluhmki E, Dávalos A, Erilä T, Ford GA, Grond M, Hacke W, et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is responsible for the safe implementation of thrombolysis in stroke-MOnitoring STUDy Investigators?. ### Response: Wahlgren N, Ahmed N, Eriksson N, Aichner F, Bluhmki E, Dávalos A, Erilä T, Ford GA, Grond M, Hacke W, et al.


Instruction: What is the Safe Implementation of Thrombolysis in Stroke-MOnitoring STudy Investigators?

Output: Multivariable analysis of outcome predictors and adjustment of main outcome results to baseline data profile in randomized controlled trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Safe Implementation of Thrombolysis in Stroke-MOnitoring STudy Investigators?. ### Response: Multivariable analysis of outcome predictors and adjustment of main outcome results to baseline data profile in randomized controlled trials.


Instruction: What are the results of the multivariable analysis of outcome predictors and adjustment of main outcome results to?

Output: baseline data profile

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of the multivariable analysis of outcome predictors and adjustment of main outcome results to?. ### Response: baseline data profile.


Instruction: How did video training improve the NIH Stroke Scale reliability?

Output: using video training

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did video training improve the NIH Stroke Scale reliability?. ### Response: using video training.


Instruction: What is the name of the group that improved the reliability of the nih Stroker Scale using video training?

Output: NINDS TPA Stroke Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that improved the reliability of the nih Stroker Scale using video training?. ### Response: NINDS TPA Stroke Study Group.


Instruction: When did the NINDS TPA strike study group release their findings?

Output: 2000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the NINDS TPA strike study group release their findings?. ### Response: 2000.


Instruction: What is the NIH Stroke Scale reliability in ratings from a large sample of clinicians?

Output: 75

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the NIH Stroke Scale reliability in ratings from a large sample of clinicians?. ### Response: 75.


Instruction: What is reliable across multiple venues?

Output: Stroke Scale certification

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reliable across multiple venues?. ### Response: Stroke Scale certification.


Instruction: What is the name of the study that studies the relationship of the National Institutes of Health Stroke Scale to 30-day mortality in Medicare beneficiaries?

Output: NINDS TPA Stroke Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that studies the relationship of the National Institutes of Health Stroke Scale to 30-day mortality in Medicare beneficiaries?. ### Response: NINDS TPA Stroke Study Group.


Instruction: What is the Health Stroke Scale to 30-day mortality in Medicare beneficiaries with acute ischemic stroke?

Output: Relationship

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Health Stroke Scale to 30-day mortality in Medicare beneficiaries with acute ischemic stroke?. ### Response: Relationship.


Instruction: What was the J Am Heart Assoc. 2012;1:42–50?

Output: Relationship of National Institutes of Health Stroke Scale to 30-day mortality in Medicare beneficiaries with acute ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the J Am Heart Assoc. 2012;1:42–50?. ### Response: Relationship of National Institutes of Health Stroke Scale to 30-day mortality in Medicare beneficiaries with acute ischemic stroke.


Instruction: What should be initiated by a heart failure specialist with access to a multidisciplinary heart fail ure team?

Output: Ivabradine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be initiated by a heart failure specialist with access to a multidisciplinary heart fail ure team?. ### Response: Ivabradine.


Instruction: What should be carried out by a heart failure specialist?

Output: Dose titration and monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be carried out by a heart failure specialist?. ### Response: Dose titration and monitoring.


Instruction: What should a GP with a special interest in heart failure do in primary care?

Output: Dose titration and monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should a GP with a special interest in heart failure do in primary care?. ### Response: Dose titration and monitoring.


Instruction: Who should do dose titration and monitoring?

Output: the most appropriate team members

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should do dose titration and monitoring?. ### Response: the most appropriate team members.


Instruction: What is Sacubitril valsartan recommended for treating?

Output: symptomatic chronic heart failure with reduced ejection fraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Sacubitril valsartan recommended for treating?. ### Response: symptomatic chronic heart failure with reduced ejection fraction.


Instruction: What is the recommended option for treating symptomatic chronic heart failure with reduced ejection fraction?

Output: Digoxin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommended option for treating symptomatic chronic heart failure with reduced ejection fraction?. ### Response: Digoxin.


Instruction: What is the name of the New York Hear t Association?

Output: NYHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the New York Hear t Association?. ### Response: NYHA.


Instruction: What does NYHA stand for?

Output: New York Hear t Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does NYHA stand for?. ### Response: New York Hear t Association.


Instruction: How much is the left ventricular ejection fraction?

Output: 35%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much is the left ventricular ejection fraction?. ### Response: 35%.


Instruction: Who should start treatment with sacubitril valsartan?

Output: a heart failure specialist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should start treatment with sacubitril valsartan?. ### Response: a heart failure specialist.


Instruction: Who should have access to a multidisciplinary heart failure team?

Output: a heart failure specialist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should have access to a multidisciplinary heart failure team?. ### Response: a heart failure specialist.


Instruction: What should be performed by the most appropriate team members?

Output: Dose titration  and monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be performed by the most appropriate team members?. ### Response: Dose titration  and monitoring.


Instruction: What is NICE’s guideline on chronic heart failure in adults: diagnosis and management?

Output: Dose titration  and monitoring should be performed by the most appropriate team members

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE’s guideline on chronic heart failure in adults: diagnosis and management?. ### Response: Dose titration  and monitoring should be performed by the most appropriate team members.


Instruction: What may continue without change to whatever arrangements were in place for them before this guidance was published?

Output: Treatment of those patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may continue without change to whatever arrangements were in place for them before this guidance was published?. ### Response: Treatment of those patients.


Instruction: What may affect the position of patients whose treatment wi th sacubitril valsartan was started within the NHS?

Output: With a left ventricular ejection fraction of 35% or less

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may affect the position of patients whose treatment wi th sacubitril valsartan was started within the NHS?. ### Response: With a left ventricular ejection fraction of 35% or less.


Instruction: What was published until they and their N HS clinician consider it appropriate to stop?

Output: this guidance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was published until they and their N HS clinician consider it appropriate to stop?. ### Response: this guidance.


Instruction: Hydralazine in combination with nitrate 57.

Output: Hydralazine in combination with nitrate  57. Seek specialist advice and consider offering h ydralazine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hydralazine in combination with nitrate 57.. ### Response: Hydralazine in combination with nitrate  57. Seek specialist advice and consider offering h ydralazine.


Instruction: Seek specialist advice and consider offering what?

Output: h ydralazine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Seek specialist advice and consider offering what?. ### Response: h ydralazine.


Instruction: What type of heart failure is the person of African or Caribbean family considered to be?

Output: severe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of heart failure is the person of African or Caribbean family considered to be?. ### Response: severe.


Instruction: What is the ejection fraction of a person with atrial fibrillation considered to have?

Output: 35%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ejection fraction of a person with atrial fibrillation considered to have?. ### Response: 35%.


Instruction: Digoxin is recommended for people with what condition?

Output: atrial fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Digoxin is recommended for people with what condition?. ### Response: atrial fibrillation.


Instruction: What is the NICE guideline on atrial fibrillation?

Output: 58

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the NICE guideline on atrial fibrillation?. ### Response: 58.


Instruction: What is recommended for worsening or severe heart failure with reduced ejection fraction?

Output: Digoxin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for worsening or severe heart failure with reduced ejection fraction?. ### Response: Digoxin.


Instruction: Seek specialist advice before initiating what?

Output: Digoxin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Seek specialist advice before initiating what?. ### Response: Digoxin.


Instruction: What is not recommended for routine monitoring of serum digoxin concentrations?

Output: A digoxin concentration measured within 8 –12 hours of the last dose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended for routine monitoring of serum digoxin concentrations?. ### Response: A digoxin concentration measured within 8 –12 hours of the last dose.


Instruction: How long after the last dose is it useful to confirm a clinical impression of toxicity or non-adherence?

Output: 8 –12 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after the last dose is it useful to confirm a clinical impression of toxicity or non-adherence?. ### Response: 8 –12 hours.


Instruction: What year was there a non -adherence?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was there a non -adherence?. ### Response: 2003.


Instruction: What was the name of the non adherence in 2003?

Output: toxicity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the non adherence in 2003?. ### Response: toxicity.


Instruction: What is the name of the NICE guideline on digoxin for people with atrial fibrillation?

Output: 58

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the NICE guideline on digoxin for people with atrial fibrillation?. ### Response: 58.


Instruction: What is the NICE guideline on atrial fibrillation called?

Output: 58

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the NICE guideline on atrial fibrillation called?. ### Response: 58.


Instruction: How manymL/min are the Guidelines for Prevention of Stroke in Women?

Output: 1571

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How manymL/min are the Guidelines for Prevention of Stroke in Women?. ### Response: 1571.


Instruction: What type of disease is advanced liver disease?

Output: impaired baseline clotting function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of disease is advanced liver disease?. ### Response: impaired baseline clotting function.


Instruction: Depression is associated with increased risk of what?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Depression is associated with increased risk of what?. ### Response: stroke.


Instruction: Depression is associated with increased risk of stroke inci-dence among women and men?

Output: 399

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Depression is associated with increased risk of stroke inci-dence among women and men?. ### Response: 399.


Instruction: In the INTERSTROKE case-control study of stroke participants from 22 countries, what was self-reported depression defined as?

Output: feeling sad, blue, or depressed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the INTERSTROKE case-control study of stroke participants from 22 countries, what was self-reported depression defined as?. ### Response: feeling sad, blue, or depressed.


Instruction: Depression is defined as feeling sad, blue, or depressed for how many consecutive weeks dur-ing the past 12 months?

Output: ≥2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Depression is defined as feeling sad, blue, or depressed for how many consecutive weeks dur-ing the past 12 months?. ### Response: ≥2.


Instruction: 2 consecutive weeks dur -ing the past 12 months was associated with a 35% increased odds of stroke?

Output: self-reported depression

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: 2 consecutive weeks dur -ing the past 12 months was associated with a 35% increased odds of stroke?. ### Response: self-reported depression.


Instruction: What was adjusted for age, sex, and region?

Output: multivariable models

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was adjusted for age, sex, and region?. ### Response: multivariable models.


Instruction: Psychosocial stress was defined with  a combined measure of what?

Output: general stress at home and in the workplace

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Psychosocial stress was defined with  a combined measure of what?. ### Response: general stress at home and in the workplace.


Instruction: What was associated with a 30% increased odds of stroke in the adjusted model?

Output: psychosocial stress

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with a 30% increased odds of stroke in the adjusted model?. ### Response: psychosocial stress.


Instruction: What was adjusted for sex?

Output: multivariable models

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was adjusted for sex?. ### Response: multivariable models.


Instruction: What were the multivariable models adjusted for?

Output: sex

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the multivariable models adjusted for?. ### Response: sex.


Instruction: What was not performed in the Nurses' Health Study?

Output: sex-specific anal-yses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not performed in the Nurses' Health Study?. ### Response: sex-specific anal-yses.


Instruction: Women with a history of depression had a 29% increased risk of what?

Output: incident total stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Women with a history of depression had a 29% increased risk of what?. ### Response: incident total stroke.


Instruction: What was the pooled adjusted HR in a meta-analysis of prospective studies of stroke and depres-sion?

Output: 1.45

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the pooled adjusted HR in a meta-analysis of prospective studies of stroke and depres-sion?. ### Response: 1.45.


Instruction: What percentage of the CI was 1.13-1.48)?

Output: 95

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the CI was 1.13-1.48)?. ### Response: 95.


Instruction: How much difference was found in the cumulative ORs for studies that included only men or women?

Output: no

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much difference was found in the cumulative ORs for studies that included only men or women?. ### Response: no.


Instruction: What is depression associated with?

Output: increased risk of stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is depression associated with?. ### Response: increased risk of stroke.


Instruction: What is needed to understand the mechanisms of depression and stroke?

Output: More research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed to understand the mechanisms of depression and stroke?. ### Response: More research.


Instruction: What is needed to understand the mechanisms underlying the association between depression and stroke?

Output: More research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed to understand the mechanisms underlying the association between depression and stroke?. ### Response: More research.


Instruction: What are women with depression at risk of?

Output: incident total stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are women with depression at risk of?. ### Response: incident total stroke.


Instruction: What are the most accurate to determine stroke risk?

Output: self- reported measures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the most accurate to determine stroke risk?. ### Response: self- reported measures.


Instruction: What is a lack of in many cohorts that have assessed multiple risk factors?

Output: sex-specific analyses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a lack of in many cohorts that have assessed multiple risk factors?. ### Response: sex-specific analyses.


Instruction: Depression and psychosocial stressors are more common in women, what may it be?

Output: it may be reasonable to test these risk factors in a woman-specific stroke risk score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Depression and psychosocial stressors are more common in women, what may it be?. ### Response: it may be reasonable to test these risk factors in a woman-specific stroke risk score.


Instruction: What is more common in women?

Output: depression and psychosocial stressors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more common in women?. ### Response: depression and psychosocial stressors.


Instruction: What is a woman-specific stroke risk score?

Output: depression and psychosocial stressors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a woman-specific stroke risk score?. ### Response: depression and psychosocial stressors.


Instruction: Who account for less than half of all subjects enrolled in National Institutes of Health?

Output: Women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who account for less than half of all subjects enrolled in National Institutes of Health?. ### Response: Women.


Instruction: How many subjects were enrolled in the National Institutes of Health funded stroke prevention drug trials in the past decade?

Output: less than half

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many subjects were enrolled in the National Institutes of Health funded stroke prevention drug trials in the past decade?. ### Response: less than half.


Instruction: What is underrepresented in clinical trials in surgery, overall CVD, and cancer?

Output: women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is underrepresented in clinical trials in surgery, overall CVD, and cancer?. ### Response: women.


Instruction: How many studies did we find that included patients receiving DOAC therapy for atrial fibrillation?

Output: 5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies did we find that included patients receiving DOAC therapy for atrial fibrillation?. ### Response: 5.


Instruction: What type of therapy did most of the studies include patients who required interruption of anticoagulation for an invasive procedure?

Output: DOAC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy did most of the studies include patients who required interruption of anticoagulation for an invasive procedure?. ### Response: DOAC.


Instruction: What did WITT and al 27 NOVEMBER 2018 xVOLUME 2, NUMBER 22Downloaded from http://ashpublications.org/bloodadvances/article-pdf/2/22/3257/1630010/advantces024893cg?

Output: laboratory testing to assess DOAC anticoagulant effect was3276

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did WITT and al 27 NOVEMBER 2018 xVOLUME 2, NUMBER 22Downloaded from http://ashpublications.org/bloodadvances/article-pdf/2/22/3257/1630010/advantces024893cg?. ### Response: laboratory testing to assess DOAC anticoagulant effect was3276.


Instruction: How many species are in the Enterococcus genus?

Output: >15

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many species are in the Enterococcus genus?. ### Response: >15.


Instruction: How long should Gentamicin be given for?

Output: 500 µg/mL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long should Gentamicin be given for?. ### Response: 500 µg/mL.


Instruction: What are the major species isolated from clinical sources in IE patients?

Output: E faecalis and E faecium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the major species isolated from clinical sources in IE patients?. ### Response: E faecalis and E faecium.


Instruction: Enterococci are the third leading cause of IE and account for 10% of cases in non-IDUs?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Enterococci are the third leading cause of IE and account for 10% of cases in non-IDUs?. ### Response: ≈.


Instruction: E faecalis causes 97% of what?

Output: cases of IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: E faecalis causes 97% of what?. ### Response: cases of IE.


Instruction: What is the percentage of IE cases in E faecium?

Output: ≈1% to 2%;

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the percentage of IE cases in E faecium?. ### Response: ≈1% to 2%;.


Instruction: What are the percentages of other species recommended for enterococcal IE in Tables 12 through 15?

Output: ≈1%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the percentages of other species recommended for enterococcal IE in Tables 12 through 15?. ### Response: ≈1%..


Instruction: Enterococci should be routinely tested in vitro for susceptibility to penicillin or ampicillin and van-comycin (MIC determination) and for high-level resistance to gentamicin to predict what?

Output: synergistic interactions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Enterococci should be routinely tested in vitro for susceptibility to penicillin or ampicillin and van-comycin (MIC determination) and for high-level resistance to gentamicin to predict what?. ### Response: synergistic interactions.


Instruction: What can be used to predict synergistic interactions?

Output: high-level resistance to gentamicin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be used to predict synergistic interactions?. ### Response: high-level resistance to gentamicin.


Instruction: What may be necessary to identify alternative antimicrobial regimens for enterococci?

Output: additional susceptibility tests

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be necessary to identify alternative antimicrobial regimens for enterococci?. ### Response: additional susceptibility tests.


Instruction: What are enterococci resistant to?

Output: penicillin, ampicillin, and vancomycin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are enterococci resistant to?. ### Response: penicillin, ampicillin, and vancomycin.


Instruction: What is reason-able to test for susceptibility in vitro to daptomycin and line-zolid?

Output: For strains of enterococci

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reason-able to test for susceptibility in vitro to daptomycin and line-zolid?. ### Response: For strains of enterococci.


Instruction: Where is linezolide bacteriostatic?

Output: in vitro

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is linezolide bacteriostatic?. ### Response: in vitro.


Instruction: Who is bactericidal in vivo in susceptible strains?

Output: daptomycin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is bactericidal in vivo in susceptible strains?. ### Response: daptomycin.


Instruction: What may account for relapse of infection?

Output: β-lactamase–producing enterococci

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may account for relapse of infection?. ### Response: β-lactamase–producing enterococci.


Instruction: Routine screening for -lactamase production is not what?

Output: sensitive enough

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Routine screening for -lactamase production is not what?. ### Response: sensitive enough.


Instruction: What is relatively resistant to penicillin, ampicillin, and vancomycin?

Output: enterococci

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is relatively resistant to penicillin, ampicillin, and vancomycin?. ### Response: enterococci.


Instruction: What are enterococci usually killed by monotherapy with?

Output: antimicrobials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are enterococci usually killed by monotherapy with?. ### Response: antimicrobials.


Instruction: What is the synergistic action of penicillin, ampi-cillin, or vancomycin in combination with gentamicin or streptomycin?

Output: Killing of susceptible strains of enterococci

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the synergistic action of penicillin, ampi-cillin, or vancomycin in combination with gentamicin or streptomycin?. ### Response: Killing of susceptible strains of enterococci.


Instruction: What is required to achieve sufficient concentrations of the drug at the site of the ribosomal target within the bacterial cell for bactericidal activity?

Output: extracellular environment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is required to achieve sufficient concentrations of the drug at the site of the ribosomal target within the bacterial cell for bactericidal activity?. ### Response: extracellular environment.


Instruction: What are higher than can be achieved safely in patients?

Output: con-centrations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are higher than can be achieved safely in patients?. ### Response: con-centrations.


Instruction: What can be achieved safely in patients?

Output: Gentamicin should be administered for the initial 2 weeks of therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be achieved safely in patients?. ### Response: Gentamicin should be administered for the initial 2 weeks of therapy.


Instruction: What raises the permeability of the enterococcal cell?

Output: cell wall–active agents such as penicillin, ampicillin, and vancomycin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What raises the permeability of the enterococcal cell?. ### Response: cell wall–active agents such as penicillin, ampicillin, and vancomycin.


Instruction: How can a bactericidal effect be achieved?

Output: by relatively low concentrations of an aminoglycoside

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can a bactericidal effect be achieved?. ### Response: by relatively low concentrations of an aminoglycoside.


Instruction: What is resistant to the cell wall-active agent or high concentrations of an aminoglycoside?

Output: enterococcal strain

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is resistant to the cell wall-active agent or high concentrations of an aminoglycoside?. ### Response: enterococcal strain.


Instruction: What will not result in bactericidal activity in vitro or in vivo?

Output: the combination of an aminoglycoside and the cell wall–active agent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will not result in bactericidal activity in vitro or in vivo?. ### Response: the combination of an aminoglycoside and the cell wall–active agent.


Instruction: No large trials have evaluated the effects of beta blockers on what?

Output: survival or coronary event rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No large trials have evaluated the effects of beta blockers on what?. ### Response: survival or coronary event rates.


Instruction: What are some of the clinical important differences between betablockers?

Output: cardioselectivity, pres-ence of intrinsic sympathomimetic activity or vasodilatingproperties, and relative lipid solubility in the presence of renalor hepatic impairment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the clinical important differences between betablockers?. ### Response: cardioselectivity, pres-ence of intrinsic sympathomimetic activity or vasodilatingproperties, and relative lipid solubility in the presence of renalor hepatic impairment.


Instruction: What does cardioselectivity, intrinsic sympathomimetic activity or vasodilatingproperties have?

Output: pres-ence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does cardioselectivity, intrinsic sympathomimetic activity or vasodilatingproperties have?. ### Response: pres-ence.


Instruction: What does relative lipid solubility in the presence of renal or hepatic impairment do?

Output: all betablockers seem to be equally efficacious

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does relative lipid solubility in the presence of renal or hepatic impairment do?. ### Response: all betablockers seem to be equally efficacious.


Instruction: All betablockers seem to be equally efficacious in what type of SIHD?

Output: dihydropyridine calcium channel blockers in controlledclinical trials. The results of the APSIS (Angina PrognosisStudy in Stockholm), TIBBS (Total Ischemic Burden Biso-prolol Study), and IMAGE (International Multicenter AnginaExercise) studies showed that a beta blocker was moreeffective than a calcium channel blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: All betablockers seem to be equally efficacious in what type of SIHD?. ### Response: dihydropyridine calcium channel blockers in controlledclinical trials. The results of the APSIS (Angina PrognosisStudy in Stockholm), TIBBS (Total Ischemic Burden Biso-prolol Study), and IMAGE (International Multicenter AnginaExercise) studies showed that a beta blocker was moreeffective than a calcium channel blocker.


Instruction: How many large long-term follow-up studies showed that all-causemortality rate progressively increases with higher heart rate?

Output: Two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many large long-term follow-up studies showed that all-causemortality rate progressively increases with higher heart rate?. ### Response: Two.


Instruction: What does all-causemortality rate progressively increase with higher resting heart rate?

Output: exercise capacity, age, diabetesmellitus, systolic arterial pressure, BMI, and level of physicalactivity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does all-causemortality rate progressively increase with higher resting heart rate?. ### Response: exercise capacity, age, diabetesmellitus, systolic arterial pressure, BMI, and level of physicalactivity.


Instruction: What should be adjusted to limit the heart rate to 55 to 60 beats perminute at rest?

Output: beta-blockerdosing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be adjusted to limit the heart rate to 55 to 60 beats perminute at rest?. ### Response: beta-blockerdosing.


Instruction: How many beats per minute at rest?

Output: 55 to 60

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many beats per minute at rest?. ### Response: 55 to 60.


Instruction: Bisoprolol, carvedilol andmetoprolol have been shown to reduce the risk of death and improve symptoms,clinical status, and quality of life in patients with chronicsystolic heart failure?

Output: digoxin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Bisoprolol, carvedilol andmetoprolol have been shown to reduce the risk of death and improve symptoms,clinical status, and quality of life in patients with chronicsystolic heart failure?. ### Response: digoxin.


Instruction: What is the name of the gene encoding for the beta-adrenergic receptor?

Output: genotype

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the gene encoding for the beta-adrenergic receptor?. ### Response: genotype.


Instruction: What has been shown by studies on multiple polymorphisms in the gene?

Output: asso-ciations with physiological responses to exercise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been shown by studies on multiple polymorphisms in the gene?. ### Response: asso-ciations with physiological responses to exercise.


Instruction: How do patients with chronicsystolic heart failure improve?

Output: symptoms,clinical status, and quality of life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do patients with chronicsystolic heart failure improve?. ### Response: symptoms,clinical status, and quality of life.


Instruction: What have studies with a variety of beta blockers yielded in terms of associations with BP and heartrate?

Output: diver-gent results

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have studies with a variety of beta blockers yielded in terms of associations with BP and heartrate?. ### Response: diver-gent results.


Instruction: What remains to be studied whether this variation is mainly a function of beta-adrenergic receptor genotype?

Output: BP and heartrate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What remains to be studied whether this variation is mainly a function of beta-adrenergic receptor genotype?. ### Response: BP and heartrate.


Instruction: What influences the clinical outcome of beta-blocker use in patients with SIHD?

Output: beta-adrenergic receptor genotype

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What influences the clinical outcome of beta-blocker use in patients with SIHD?. ### Response: beta-adrenergic receptor genotype.


Instruction: What has been compared with and combined with dihydropyridine calcium channel blockers in controlledclinical trials?

Output: Beta blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been compared with and combined with dihydropyridine calcium channel blockers in controlledclinical trials?. ### Response: Beta blockers.


Instruction: What did the Burden Biso-prolol Study) and IMAGE (International Multicenter AnginaExercise) studies show?

Output: a beta blocker was moreeffective

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Burden Biso-prolol Study) and IMAGE (International Multicenter AnginaExercise) studies show?. ### Response: a beta blocker was moreeffective.


Instruction: What was more effective than a calcium channel blocker in control of angina?

Output: beta blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was more effective than a calcium channel blocker in control of angina?. ### Response: beta blocker.


Instruction: Beta blockers and dihydropyri-dine calcium channel blockers have shown a trend toward a lower rate of what?

Output: cardiovascularoutcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Beta blockers and dihydropyri-dine calcium channel blockers have shown a trend toward a lower rate of what?. ### Response: cardiovascularoutcomes.


Instruction: What is caution warranted when a beta blocker is combined with verapamil or diltiazem because of the potential for development of bradycardia?

Output: it is recommended that beta-blockerdosing be adjusted to limit the heart rate to 55 to 60 beats perminute at rest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is caution warranted when a beta blocker is combined with verapamil or diltiazem because of the potential for development of bradycardia?. ### Response: it is recommended that beta-blockerdosing be adjusted to limit the heart rate to 55 to 60 beats perminute at rest.


Instruction: What is bradycardia?

Output: dihydropyridine-induced tachycardia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is bradycardia?. ### Response: dihydropyridine-induced tachycardia.


Instruction: What is excessivefatigue?

Output: bradycardia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is excessivefatigue?. ### Response: bradycardia.


Instruction: What does CEA stand for?

Output: carotid endarterectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CEA stand for?. ### Response: carotid endarterectomy.


Instruction: What is the term for a small infarct core with large territory at risk?

Output: penumbra

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for a small infarct core with large territory at risk?. ### Response: penumbra.


Instruction: What is stenosis or occlusion?

Output: critical carotid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is stenosis or occlusion?. ### Response: critical carotid.


Instruction: What is not well established in the case of acute neurological deficit after CEA?

Output: acute thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not well established in the case of acute neurological deficit after CEA?. ### Response: acute thrombosis.


Instruction: What does ACC/AHA 2015 Recommendation Classification System conform to?

Output: LOE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ACC/AHA 2015 Recommendation Classification System conform to?. ### Response: LOE.


Instruction: What is the original wording of Table XCV in online Data Supplement 1?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the original wording of Table XCV in online Data Supplement 1?. ### Response: 2.


Instruction: In patients with unstable neurological status, what is the efficacy of emergency CEA/carotid angioplasty and stenting not well established?

Output: efficacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with unstable neurological status, what is the efficacy of emergency CEA/carotid angioplasty and stenting not well established?. ### Response: efficacy.


Instruction: How was the 2013 AIS Guidelines reworded?

Output: No BenefitB-R Recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the 2013 AIS Guidelines reworded?. ### Response: No BenefitB-R Recommendation.


Instruction: What was the LOE amended to conform with?

Output: ACC/AHA 2015 Recommendation Classification System

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the LOE amended to conform with?. ### Response: ACC/AHA 2015 Recommendation Classification System.


Instruction: Where is Table XCV located?

Output: online Data Supplement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Table XCV located?. ### Response: online Data Supplement.


Instruction: What is not recommended for the treatment of AIS?

Output: Transcranial near-infrared laser therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended for the treatment of AIS?. ### Response: Transcranial near-infrared laser therapy.


Instruction: What did previous data suggest that transcranial near-infrared laser therapy held promise as a therapeutic intervention?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did previous data suggest that transcranial near-infrared laser therapy held promise as a therapeutic intervention?. ### Response: stroke.


Instruction: What is NEST?

Output: Neurothera Effectiveness and Safety Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NEST?. ### Response: Neurothera Effectiveness and Safety Trial.


Instruction: What was the NEST-3 trial?

Output: a prospective RCT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the NEST-3 trial?. ### Response: a prospective RCT.


Instruction: How long did the transcranial laser therapy take to treat stroke?

Output: between 4.5 and 24 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the transcranial laser therapy take to treat stroke?. ### Response: between 4.5 and 24 hours.


Instruction: What was the NIHSS score of patients with moderate stroke?

Output: 7–17

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the NIHSS score of patients with moderate stroke?. ### Response: 7–17.


Instruction: Why was the study terminated?

Output: futility

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the study terminated?. ### Response: futility.


Instruction: How many patients were analyzed in the study?

Output: 566

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were analyzed in the study?. ### Response: 566.


Instruction: What is the current status of transcranial laser therapy?

Output: There is currently no evidence that transcranial laser therapy is beneficial in the treatment of ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the current status of transcranial laser therapy?. ### Response: There is currently no evidence that transcranial laser therapy is beneficial in the treatment of ischemic stroke.


Instruction: What type of laser therapy is better than sham treatment?

Output: transcranial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of laser therapy is better than sham treatment?. ### Response: transcranial.


Instruction: What is the current status of transcranial laser therapy in the treatment of ischemic stroke?

Output: not recommended

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the current status of transcranial laser therapy in the treatment of ischemic stroke?. ### Response: not recommended.


Instruction: Where is the table LIV in online Data Supplement 1.3.11 located?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the table LIV in online Data Supplement 1.3.11 located?. ### Response: http://ahajournals.org.


Instruction: What type of heart failure is referred to as NICE 2018?

Output: Chronic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of heart failure is referred to as NICE 2018?. ### Response: Chronic.


Instruction: What is the ISBN for Chronic Heart Failure Referral and approach to care?

Output: 978 -1-4731 -3093 -7 412 9.4.4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ISBN for Chronic Heart Failure Referral and approach to care?. ### Response: 978 -1-4731 -3093 -7 412 9.4.4.


Instruction: How many economic evaluations were identified?

Output: No

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many economic evaluations were identified?. ### Response: No.


Instruction: What is the economic article selection flow chart in Appendix D?

Output: No relevant economic evaluations were identified

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the economic article selection flow chart in Appendix D?. ### Response: No relevant economic evaluations were identified.


Instruction: What is the average mm Hg for women?

Output: ≥160

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the average mm Hg for women?. ### Response: ≥160.


Instruction: What is it for men that is 140 to 159?

Output: ≥160 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is it for men that is 140 to 159?. ### Response: ≥160 mm Hg.


Instruction: Who is the author of this study?

Output: Butler et al19

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of this study?. ### Response: Butler et al19.


Instruction: What is the British Cardiovascular Society's recommendation for the Treatment of Hypertension in Stage A HF?

Output: Asymptomatic p atients at risk for HFrecommendation Cor LoEreferenced Guideline references

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the British Cardiovascular Society's recommendation for the Treatment of Hypertension in Stage A HF?. ### Response: Asymptomatic p atients at risk for HFrecommendation Cor LoEreferenced Guideline references.


Instruction: What should be controlled in accordance with contemporary guidelines?

Output: Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be controlled in accordance with contemporary guidelines?. ### Response: Hypertension.


Instruction: What indicates Class of Recommendation?

Output: I A 7–914, 21–28, 30, 31COR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates Class of Recommendation?. ### Response: I A 7–914, 21–28, 30, 31COR.


Instruction: What indicates LOE?

Output: Level of Evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates LOE?. ### Response: Level of Evidence.


Instruction: What should be considered in the evaluation of patients with HF symptoms?

Output: Prosthesis–patient mismatch and functional stenosis of a repaired native valve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered in the evaluation of patients with HF symptoms?. ### Response: Prosthesis–patient mismatch and functional stenosis of a repaired native valve.


Instruction: What type of assessment begins with trans-thoracic assessment?

Output: Repeat noninvasive assessment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of assessment begins with trans-thoracic assessment?. ### Response: Repeat noninvasive assessment.


Instruction: What is the preferred approach for initial assessment of suspected prosthetic valve dysfunction?

Output: TTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the preferred approach for initial assessment of suspected prosthetic valve dysfunction?. ### Response: TTE.


Instruction: What does TTE allow for?

Output: measurement of transvalvular velocity, gradient, and valve area

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does TTE allow for?. ### Response: measurement of transvalvular velocity, gradient, and valve area.


Instruction: What is the initial assessment of suspected prosthetic valve dysfunction?

Output: TTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the initial assessment of suspected prosthetic valve dysfunction?. ### Response: TTE.


Instruction: What allows quantita-tion of LV volumes and LVEF?

Output: TTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What allows quantita-tion of LV volumes and LVEF?. ### Response: TTE.


Instruction: What obscures the LA side of a prosthetic mitral valve?

Output: acoustic shadowing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What obscures the LA side of a prosthetic mitral valve?. ### Response: acoustic shadowing.


Instruction: What results in reduced sensi-tivity for detection of prosthetic MR, pannus, or vegetation?

Output: the LA side of a prosthetic mitral valve is obscured by acoustic shadowing from the TTE approach

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What results in reduced sensi-tivity for detection of prosthetic MR, pannus, or vegetation?. ### Response: the LA side of a prosthetic mitral valve is obscured by acoustic shadowing from the TTE approach.


Instruction: TEE provides superior imaging of what side of the prosthesis?

Output: LA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: TEE provides superior imaging of what side of the prosthesis?. ### Response: LA.


Instruction: What is accurate for diagnosis of prosthetic mitral valve dysfunction?

Output: TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is accurate for diagnosis of prosthetic mitral valve dysfunction?. ### Response: TEE.


Instruction: What is needed for patients with prosthetic aortic valves in which the posterior aspect of the valve is shadowed on the TTE approach?

Output: TTE and TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed for patients with prosthetic aortic valves in which the posterior aspect of the valve is shadowed on the TTE approach?. ### Response: TTE and TEE.


Instruction: On which approach is the anterior aspect of the valve shadowed?

Output: TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On which approach is the anterior aspect of the valve shadowed?. ### Response: TEE.


Instruction: Which approach has superior sensitivity for the detection of vegetations and abscess formation in patients with suspected prosthetic valve endocarditis?

Output: TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which approach has superior sensitivity for the detection of vegetations and abscess formation in patients with suspected prosthetic valve endocarditis?. ### Response: TEE.


Instruction: What can help detect mechanical valve obstruction?

Output: fluoroscopy or CT imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can help detect mechanical valve obstruction?. ### Response: fluoroscopy or CT imaging.


Instruction: What can CT imaging help detect?

Output: reduced motion caused by pannus ingrowth or thrombus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can CT imaging help detect?. ### Response: reduced motion caused by pannus ingrowth or thrombus.


Instruction: How much of patients with a surgical aortic valve bioprosthesis develop evidence of over the 10 years after surgery?

Output: 30%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of patients with a surgical aortic valve bioprosthesis develop evidence of over the 10 years after surgery?. ### Response: 30%.


Instruction: How long does it take for a patient to develop evidence of valve dysfunction?

Output: 10 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take for a patient to develop evidence of valve dysfunction?. ### Response: 10 years.


Instruction: What is an increase in mean gradient of 10 mm Hg or a worsening of transprosthetic regurgitation from mild to moderate or from moderate to severe?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an increase in mean gradient of 10 mm Hg or a worsening of transprosthetic regurgitation from mild to moderate or from moderate to severe?. ### Response: ≥.


Instruction: How long after surgery does clinically important structural valve deterioration increase?

Output: more than 10 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after surgery does clinically important structural valve deterioration increase?. ### Response: more than 10 years.


Instruction: What is the risk factor associated with accelerated (5 years) valve deteriorion?

Output: young age (<60 years) at implantation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk factor associated with accelerated (5 years) valve deteriorion?. ### Response: young age (<60 years) at implantation.


Instruction: How old is the patient at implantation, smoking, and chronic kidney disease?

Output: (<60 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old is the patient at implantation, smoking, and chronic kidney disease?. ### Response: (<60 years.


Instruction: What is the name of the disease that causes diabetes mellitus?

Output: diabe-tes mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease that causes diabetes mellitus?. ### Response: diabe-tes mellitus.


Instruction: How many patients are at risk for TTE?

Output: up to 13%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients are at risk for TTE?. ### Response: up to 13%.


Instruction: What may be considered for at-risk patients on an individual basis?

Output: The selec-tive adoption of an earlier, annual TTE screening program

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered for at-risk patients on an individual basis?. ### Response: The selec-tive adoption of an earlier, annual TTE screening program.


Instruction: What was the date of 1402 Hypertension?

Output: June 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the date of 1402 Hypertension?. ### Response: June 2015.


Instruction: What is Valsartan in Acute Myocardial Infarction Trial Investigators?

Output: captopril

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Valsartan in Acute Myocardial Infarction Trial Investigators?. ### Response: captopril.


Instruction: What drug is used in acute myocardial infarction?

Output: Valsartan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug is used in acute myocardial infarction?. ### Response: Valsartan.


Instruction: What is another name for Valsartan?

Output: captopril

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for Valsartan?. ### Response: captopril.


Instruction: When was the N Engl J Med 349:1893-1906?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the N Engl J Med 349:1893-1906?. ### Response: 2003.


Instruction: Who is the ACCOMPLISH Trial Investigator?

Output: Jamerson K, Weber MA, Bakris GL, Dahlof B, Pitt B, Shi V , Hester A, Gupte J, Gatlin M, Velazequez EJ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the ACCOMPLISH Trial Investigator?. ### Response: Jamerson K, Weber MA, Bakris GL, Dahlof B, Pitt B, Shi V , Hester A, Gupte J, Gatlin M, Velazequez EJ.


Instruction: What does Benazepril plus amlodipine or hydrochlorothiazide do for hypertension in high-risk patients?

Output: Major outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Benazepril plus amlodipine or hydrochlorothiazide do for hypertension in high-risk patients?. ### Response: Major outcomes.


Instruction: When did N Engl J Med. 2008:359:2417-2428?

Output: 93

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did N Engl J Med. 2008:359:2417-2428?. ### Response: 93.


Instruction: What is the average diastolic blood pressure?

Output: 90 through 114 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the average diastolic blood pressure?. ### Response: 90 through 114 mm Hg.


Instruction: When was the JAMA published?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the JAMA published?. ### Response: 2002.


Instruction: What was the main result of the MRC trial?

Output: treatment of mild hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the main result of the MRC trial?. ### Response: treatment of mild hypertension.


Instruction: What is the name of the Systolic Hypertension in the Elderly Program?

Output: SHEP): SHEP Cooperative Research Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Systolic Hypertension in the Elderly Program?. ### Response: SHEP): SHEP Cooperative Research Group.


Instruction: When was SHEP Cooperative Research Group founded?

Output: 1991

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was SHEP Cooperative Research Group founded?. ### Response: 1991.


Instruction: What was the main outcome of the ALLHAT Collaborative Research Group?

Output: high-risk hyperten-sive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the main outcome of the ALLHAT Collaborative Research Group?. ### Response: high-risk hyperten-sive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic.


Instruction: What is the name of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial?

Output: ALLHAT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial?. ### Response: ALLHAT.


Instruction: What are the major outcomes in high-risk hyperten-sive patients randomized to?

Output: angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the major outcomes in high-risk hyperten-sive patients randomized to?. ### Response: angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic.


Instruction: What is the name of the study that investigated the adverse prognostic signifi-cance of new diabetes in treated hypertensive subjects?

Output: Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the adverse prognostic signifi-cance of new diabetes in treated hypertensive subjects?. ### Response: Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial.


Instruction: What was the title of this study?

Output: ACCOMPLISH Trial Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the title of this study?. ### Response: ACCOMPLISH Trial Investigators.


Instruction: In what year did Hypertension 43:963-969?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did Hypertension 43:963-969?. ### Response: 2004.


Instruction: What is the name of the study that evaluated antihypertensive and lipid-lowering treatment to prevent heart attack?

Output: ALLHAT Collaborative Research Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated antihypertensive and lipid-lowering treatment to prevent heart attack?. ### Response: ALLHAT Collaborative Research Group.


Instruction: What is lisinopril used for in nondiabetic individuals?

Output: hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is lisinopril used for in nondiabetic individuals?. ### Response: hypertension.


Instruction: What is the name of the trial that evaluated lisinopril as an initial treatment for hypertension?

Output: Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the trial that evaluated lisinopril as an initial treatment for hypertension?. ### Response: Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial.


Instruction: What is ALHAT?

Output: Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ALHAT?. ### Response: Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial.


Instruction: Diabetes Care. 2008;31:353–360.

Output: 98

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Diabetes Care. 2008;31:353–360.. ### Response: 98.


Instruction: What is the name of the research group that studies mortality and morbidity during and after the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial?

Output: ALLHAT Collaborative Research Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the research group that studies mortality and morbidity during and after the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial?. ### Response: ALLHAT Collaborative Research Group.


Instruction: What is Lipid-Lowering Treatment to Prevent Heart Attack?

Output: Antihypertensive

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Lipid-Lowering Treatment to Prevent Heart Attack?. ### Response: Antihypertensive.


Instruction: What is Greenwich's J Clin Hypertens?

Output: Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Greenwich's J Clin Hypertens?. ### Response: Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial.


Instruction: What were people with heart failure often unaware of?

Output: the term ‘heart failure’

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were people with heart failure often unaware of?. ### Response: the term ‘heart failure’.


Instruction: What did many describe that the term was not mentioned initially but introduced later by specialists?

Output: heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did many describe that the term was not mentioned initially but introduced later by specialists?. ### Response: heart failure.


Instruction: What was the subfinding based on?

Output: si x studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the subfinding based on?. ### Response: si x studies.


Instruction: What did shock and confusion cause?

Output: patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did shock and confusion cause?. ### Response: patients.


Instruction: S4.4-42. Bundy JD, Li C, Stuchlik P, et al. Systolic blood pressure reduction and risk of cardiovascular disease and mortality: a systematic review and network meta-analysis. 2017;2:775–81.

Output: 288:2421–31

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: S4.4-42. Bundy JD, Li C, Stuchlik P, et al. Systolic blood pressure reduction and risk of cardiovascular disease and mortality: a systematic review and network meta-analysis. 2017;2:775–81.. ### Response: 288:2421–31.


Instruction: Ruggenenti P, Perna A, Loriga G, and Ruggenti P. What is blood-pressure control for in patients with non-diabetic chronic renal disease?

Output: renoprotection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Ruggenenti P, Perna A, Loriga G, and Ruggenti P. What is blood-pressure control for in patients with non-diabetic chronic renal disease?. ### Response: renoprotection.


Instruction: What is the name of the multicentre, randomised controlled trial in non-diabetic chronic renal dis-ease?

Output: REIN-2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multicentre, randomised controlled trial in non-diabetic chronic renal dis-ease?. ### Response: REIN-2.


Instruction: What does REIN-2 stand for?

Output: Blood-pressure control for renoprotection in patients with non-diabetic chronic renal dis-ease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does REIN-2 stand for?. ### Response: Blood-pressure control for renoprotection in patients with non-diabetic chronic renal dis-ease.


Instruction: When did the AASK trial take place?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the AASK trial take place?. ### Response: 2002.


Instruction: What is hypertensive kidney disease?

Output: AASK trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hypertensive kidney disease?. ### Response: AASK trial.


Instruction: When was the AASK trial published?

Output: 2002;288:2421–31.Downloaded from http://ahajournals.org by on May 1, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the AASK trial published?. ### Response: 2002;288:2421–31.Downloaded from http://ahajournals.org by on May 1, 2023.


Instruction: What was the name of the trial?

Output: AASK trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the trial?. ### Response: AASK trial.


Instruction: What should anticoagulant and antiplatelet therapy be ad-justed when necessary for CKD to decrease the risk of bleeding in patients with NSTE-ACS?

Output: weight-based where appropriate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should anticoagulant and antiplatelet therapy be ad-justed when necessary for CKD to decrease the risk of bleeding in patients with NSTE-ACS?. ### Response: weight-based where appropriate.


Instruction: What is a strategy of routine blood transfusion in hemody-namically stable patients?

Output: not recommend-ed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a strategy of routine blood transfusion in hemody-namically stable patients?. ### Response: not recommend-ed.


Instruction: What is not recommended in hemody-namically stable patients with NSTE-ACS?

Output: routine blood transfusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended in hemody-namically stable patients with NSTE-ACS?. ### Response: routine blood transfusion.


Instruction: What is associated with an increased risk for Holter monitor-detected recurrent ischemia and MACE?

Output: Anemia in patients with ACS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with an increased risk for Holter monitor-detected recurrent ischemia and MACE?. ### Response: Anemia in patients with ACS.


Instruction: What is the risk of anemia in patients with NSTE-ACS with hemoglobin levels 11 g/dL?

Output: adverse outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of anemia in patients with NSTE-ACS with hemoglobin levels 11 g/dL?. ### Response: adverse outcome.


Instruction: What are the potentially detrimental effects of severe anemia?

Output: decreased myocardial oxygen delivery and increased MVO2 related to maintenance of a higher cardiac output

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the potentially detrimental effects of severe anemia?. ### Response: decreased myocardial oxygen delivery and increased MVO2 related to maintenance of a higher cardiac output.


Instruction: What are the two main causes of severe anemia?

Output: decreased myocardial oxygen delivery and increased MVO2 related to maintenance of a higher cardiac output

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the two main causes of severe anemia?. ### Response: decreased myocardial oxygen delivery and increased MVO2 related to maintenance of a higher cardiac output.


Instruction: What are patients with anemia less likely to be treated with?

Output: aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients with anemia less likely to be treated with?. ### Response: aspirin.


Instruction: Patients with ACS and anemia are likely to have more bleeding complica-tions with what?

Output: PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with ACS and anemia are likely to have more bleeding complica-tions with what?. ### Response: PCI.


Instruction: What has been correlated with increased short-term risk of MACE outcomes?

Output: bleeding complica-tions with PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been correlated with increased short-term risk of MACE outcomes?. ### Response: bleeding complica-tions with PCI.


Instruction: What study suggests that the risk of mortality associated with bleeding is at least as great as that associated with procedure-related or spontaneous MI?

Output: ACUITY

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What study suggests that the risk of mortality associated with bleeding is at least as great as that associated with procedure-related or spontaneous MI?. ### Response: ACUITY.


Instruction: What is a coprimary endpoint in many trials?

Output: Major bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a coprimary endpoint in many trials?. ### Response: Major bleeding.


Instruction: What is considered when assessing the "net clinical ben-efit" of a new drug?

Output: Major bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is considered when assessing the "net clinical ben-efit" of a new drug?. ### Response: Major bleeding.


Instruction: A "universal definition of bleeding" has been proposed to assist clinicians what?

Output: 547

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A "universal definition of bleeding" has been proposed to assist clinicians what?. ### Response: 547.


Instruction: How does the incidence of major bleeding in patients with ACS vary?

Output: widely

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does the incidence of major bleeding in patients with ACS vary?. ### Response: widely.


Instruction: What is one of the factors that contributes to an increased bleeding risk in ACS patients?

Output: older age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the factors that contributes to an increased bleeding risk in ACS patients?. ### Response: older age.


Instruction: What is the risk of CKD?

Output: bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of CKD?. ### Response: bleeding.


Instruction: What are non-weight-based dosing of anticoagu-lants and antiplatelet medications associated with?

Output: an increased risk of bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are non-weight-based dosing of anticoagu-lants and antiplatelet medications associated with?. ### Response: an increased risk of bleeding.


Instruction: What are adjusted for CKD associated with an increased risk of?

Output: bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are adjusted for CKD associated with an increased risk of?. ### Response: bleeding.


Instruction: Bleeding is related to adverse out-comes because it may be a marker of underlying disease, such as occult malignancy?

Output: 522,697,698

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Bleeding is related to adverse out-comes because it may be a marker of underlying disease, such as occult malignancy?. ### Response: 522,697,698.


Instruction: What may prompt transfusion which itself may have adverse effects?

Output: Bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may prompt transfusion which itself may have adverse effects?. ### Response: Bleeding.


Instruction: What can transfusion cause?

Output: hypotension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can transfusion cause?. ### Response: hypotension.


Instruction: What can be fatal if intracranial?

Output: bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be fatal if intracranial?. ### Response: bleeding.


Instruction: Proton pump inhibitors decrease the risk of upper GI bleeding in patients treated with what?

Output: DAPT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Proton pump inhibitors decrease the risk of upper GI bleeding in patients treated with what?. ### Response: DAPT.


Instruction: What is an option in patients at increased risk of GI bleeding?

Output: Proton pump inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an option in patients at increased risk of GI bleeding?. ### Response: Proton pump inhibitors.


Instruction: What includes a focused his-and-her evaluation?

Output: the risk of bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What includes a focused his-and-her evaluation?. ### Response: the risk of bleeding.


Instruction: What are crucial prerequisites to optimize therapy for adults with Eisenmenger syndrome?

Output: hypertension by means of advanced imaging and cardiac catheterization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are crucial prerequisites to optimize therapy for adults with Eisenmenger syndrome?. ### Response: hypertension by means of advanced imaging and cardiac catheterization.


Instruction: In adults with ASD or VSD in WHO functional class III or IV, RCTs demonstrate improved what?

Output: 6-minute walk distance, hemody-namics, and subjective functional ability

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In adults with ASD or VSD in WHO functional class III or IV, RCTs demonstrate improved what?. ### Response: 6-minute walk distance, hemody-namics, and subjective functional ability.


Instruction: How long did oral bosentan last?

Output: months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did oral bosentan last?. ### Response: months.


Instruction: What has shown long-term benefit?

Output: open-label extension of this initial RCTS4.4.6.2-1 and in single-center registry cohorts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has shown long-term benefit?. ### Response: open-label extension of this initial RCTS4.4.6.2-1 and in single-center registry cohorts.


Instruction: How long has there been a class effect?

Output: months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long has there been a class effect?. ### Response: months.


Instruction: What are endothelin receptor antagonists studied for?

Output: class effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are endothelin receptor antagonists studied for?. ### Response: class effect.


Instruction: What is the name of the randomized crossover trial that enrolled adults with Eisenmenger syndrome or idiopathic PAH?

Output: combination PAH therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized crossover trial that enrolled adults with Eisenmenger syndrome or idiopathic PAH?. ### Response: combination PAH therapy.


Instruction: What did the single-center co-hort series suggest for adults with Eisenmenger syndrome?

Output: improvement in 6-minute walk testing and hemodynamics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the single-center co-hort series suggest for adults with Eisenmenger syndrome?. ### Response: improvement in 6-minute walk testing and hemodynamics.


Instruction: What was shown to improve in 6-minute walk testing and hemodynamics using combined PDE-5 inhibitory therapy?

Output: combination PAH therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was shown to improve in 6-minute walk testing and hemodynamics using combined PDE-5 inhibitory therapy?. ### Response: combination PAH therapy.


Instruction: What is the combination of PDE-5 in-hibitory therapy and endothelin receptor antago-nist therapy?

Output: PAH therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the combination of PDE-5 in-hibitory therapy and endothelin receptor antago-nist therapy?. ### Response: PAH therapy.


Instruction: What do open-label single-center registries and cohort studies of adults with Eisenmenger syndrome suggest?

Output: Longer-term benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do open-label single-center registries and cohort studies of adults with Eisenmenger syndrome suggest?. ### Response: Longer-term benefit.


Instruction: What are patients with ACHD and Down syndrome more likely to do?

Output: de-velop pulmonary hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients with ACHD and Down syndrome more likely to do?. ### Response: de-velop pulmonary hypertension.


Instruction: What are comorbidities that influence the nature of their pulmonary hypertension?

Output: unique

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are comorbidities that influence the nature of their pulmonary hypertension?. ### Response: unique.


Instruction: What type of registries and cohorts of adults with Down syndrome and Eisenmenger syndrome suggest benefit in subjective and objective functional capacity after months of endothelin re-ceptor antagonist therapy?

Output: Open-label single-center

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of registries and cohorts of adults with Down syndrome and Eisenmenger syndrome suggest benefit in subjective and objective functional capacity after months of endothelin re-ceptor antagonist therapy?. ### Response: Open-label single-center.


Instruction: What is another term for endothe-lin receptor antagonist therapy?

Output: PAH therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for endothe-lin receptor antagonist therapy?. ### Response: PAH therapy.


Instruction: Accurate diagnosis of PAH and Eisenmenger syn-drome remains essential before initiating what?

Output: such therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Accurate diagnosis of PAH and Eisenmenger syn-drome remains essential before initiating what?. ### Response: such therapy.


Instruction: What is the 2014 AHA/ACC NSTE-ACS Guideline e411 705?

Output: Amsterdam et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2014 AHA/ACC NSTE-ACS Guideline e411 705?. ### Response: Amsterdam et al.


Instruction: How does hemoglobin level affect in-hospital prognosis in patients with acute coro-nary syndrome?

Output: Influence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does hemoglobin level affect in-hospital prognosis in patients with acute coro-nary syndrome?. ### Response: Influence.


Instruction: What was the Rev Esp Cardiol. 2008;61:945–52?

Output: Influence of hemoglobin level on in-hospital prognosis in patients with acute coro-nary syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the Rev Esp Cardiol. 2008;61:945–52?. ### Response: Influence of hemoglobin level on in-hospital prognosis in patients with acute coro-nary syndrome.


Instruction: What is the effect of anemia on short- and long-term outcome in patients hospitalized for acute coronary syndrome?

Output: Effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of anemia on short- and long-term outcome in patients hospitalized for acute coronary syndrome?. ### Response: Effect.


Instruction: What does continuous electrocardiographic monitoring do?

Output: Relation between hemoglobin level and recurrent myocardial ischemia in acute coronary syndromes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does continuous electrocardiographic monitoring do?. ### Response: Relation between hemoglobin level and recurrent myocardial ischemia in acute coronary syndromes.