Instruction: What is the recommended period of withdrawal in patients receiving clopidogrel?

Output: 5 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommended period of withdrawal in patients receiving clopidogrel?. ### Response: 5 days.


Instruction: What is a P2Y12receptor inhibitor?

Output: CABG is planned and can be delayed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a P2Y12receptor inhibitor?. ### Response: CABG is planned and can be delayed.


Instruction: How long should withdrawal be in patients receiving clopidogrel13,45,99 (Level of Evidence: B) or ticagrelor*12(Level ofEvidence: C)?

Output: 5 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long should withdrawal be in patients receiving clopidogrel13,45,99 (Level of Evidence: B) or ticagrelor*12(Level ofEvidence: C)?. ### Response: 5 days.


Instruction: What should be at least 7 days in patients taking prasugrel8 (Levelof Evidence: C), unless the need forrevascularization and/or the net benefit of the P2Y12receptor inhibitor therapy outweighs the potential risks of excessbleeding?

Output: The period of withdrawalshould be at least 5 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be at least 7 days in patients taking prasugrel8 (Levelof Evidence: C), unless the need forrevascularization and/or the net benefit of the P2Y12receptor inhibitor therapy outweighs the potential risks of excessbleeding?. ### Response: The period of withdrawalshould be at least 5 days.


Instruction: What does P2Y12receptor inhibitor therapy outweigh the potential risks of?

Output: excessbleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does P2Y12receptor inhibitor therapy outweigh the potential risks of?. ### Response: excessbleeding.


Instruction: What is the 2011 recommendationmodified?

Output: ticagrelor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2011 recommendationmodified?. ### Response: ticagrelor.


Instruction: Evidence from randomized clinical tria ls on the benefits of interventions No 3.4 Document the search Yes 3.4.1 Provide a line-by-line descripti on of the search strategy, including the date of every search for each database, web browser, etc.?

Output: Yes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Evidence from randomized clinical tria ls on the benefits of interventions No 3.4 Document the search Yes 3.4.1 Provide a line-by-line descripti on of the search strategy, including the date of every search for each database, web browser, etc.?. ### Response: Yes.


Instruction: 3.4.2 Document the disposition of each report identifi ed including reasons for their exclusion if appropriate No 3.5 Manage data collection Yes 3.5.1 At a minimum, use how many researchers, working independently to extract quantitative and other critical data from each study?

Output: two or more

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: 3.4.2 Document the disposition of each report identifi ed including reasons for their exclusion if appropriate No 3.5 Manage data collection Yes 3.5.1 At a minimum, use how many researchers, working independently to extract quantitative and other critical data from each study?. ### Response: two or more.


Instruction: What could one individual extract for other types of data?

Output: the data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could one individual extract for other types of data?. ### Response: the data.


Instruction: What could the second individual independently check for?

Output: accuracy and completeness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could the second individual independently check for?. ### Response: accuracy and completeness.


Instruction: Establish a fair procedure for resolving discrepancies—do not give final decision-making power to the senior reviewer?

Output: Document the search Yes 3.4.1 Provide a line-by-line descripti on of the search strategy, including the date of every search for each database, web browser, etc. Yes 3.4.2 Document the disposition of each report identifi ed including reasons for their exclusion if appropriate No 3.5 Manage data collection Yes 3.5.1 At a minimum, use two or more researchers, working independently, to extract quantitative and other critical data from each study. For other types of data, one individual could extract the data while the second individual independently checks for accuracy and completeness. Establish a fair procedure for resolving discrepancies—do not simply give final decision-making power to the senior reviewer Single extraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Establish a fair procedure for resolving discrepancies—do not give final decision-making power to the senior reviewer?. ### Response: Document the search Yes 3.4.1 Provide a line-by-line descripti on of the search strategy, including the date of every search for each database, web browser, etc. Yes 3.4.2 Document the disposition of each report identifi ed including reasons for their exclusion if appropriate No 3.5 Manage data collection Yes 3.5.1 At a minimum, use two or more researchers, working independently, to extract quantitative and other critical data from each study. For other types of data, one individual could extract the data while the second individual independently checks for accuracy and completeness. Establish a fair procedure for resolving discrepancies—do not simply give final decision-making power to the senior reviewer Single extraction.


Instruction: Reviewer Single extraction 3.5.2 Link publications from the same study to avoid including data from same study more than once?

Output: Establish a fair procedure for resolving discrepancies—do not simply give final decision-making power to the senior reviewer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Reviewer Single extraction 3.5.2 Link publications from the same study to avoid including data from same study more than once?. ### Response: Establish a fair procedure for resolving discrepancies—do not simply give final decision-making power to the senior reviewer.


Instruction: What is a pilot study of nor -mobaric oxygen therapy in acute ischemic stroke?

Output: Singhal AB, Benner T, Roccatagliata L, Koroshetz WJ, Schaefer PW, Lo EH, Buonanno FS, Gonzalez RG, Sorensen AG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a pilot study of nor -mobaric oxygen therapy in acute ischemic stroke?. ### Response: Singhal AB, Benner T, Roccatagliata L, Koroshetz WJ, Schaefer PW, Lo EH, Buonanno FS, Gonzalez RG, Sorensen AG.


Instruction: What is the name of the study?

Output: PAIS study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study?. ### Response: PAIS study.


Instruction: How many stroke victims should receive supplemental oxygen?

Output: 435

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many stroke victims should receive supplemental oxygen?. ### Response: 435.


Instruction: What should stroke victims routinely receive?

Output: supplemental oxygen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should stroke victims routinely receive?. ### Response: supplemental oxygen.


Instruction: What is the name of the quasi-randomized controlled trial?

Output: Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the quasi-randomized controlled trial?. ### Response: Stroke.


Instruction: When was the journal Stroke.30.10.2033 435 published?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the journal Stroke.30.10.2033 435 published?. ### Response: 1999.


Instruction: How did protocol deviations before and after treatment with intravenous tissue plasminogen activator occur in community hospitals?

Output: pro-tocol violations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did protocol deviations before and after treatment with intravenous tissue plasminogen activator occur in community hospitals?. ### Response: pro-tocol violations.


Instruction: What is the name of the disease that affects drip-and-ship stroke patients?

Output: Poor hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease that affects drip-and-ship stroke patients?. ### Response: Poor hypertension.


Instruction: How many strokes were there in 2016?

Output: 04.013 437

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes were there in 2016?. ### Response: 04.013 437.


Instruction: What was the most recent issue of J Stroke Cerebrovasc Dis?

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the most recent issue of J Stroke Cerebrovasc Dis?. ### Response: 2016.


Instruction: What is the name of the disease that affects stroke patients?

Output: ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease that affects stroke patients?. ### Response: ischemic stroke.


Instruction: What are the names of the diseases that affect stroke patients in 2016?

Output: Poor hypertension control and longer trans-port times

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the diseases that affect stroke patients in 2016?. ### Response: Poor hypertension control and longer trans-port times.


Instruction: How many stroke patients are affected by tPA?

Output: 855–860

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many stroke patients are affected by tPA?. ### Response: 855–860.


Instruction: What is the name of the drug used to treat stroke?

Output: Paracetamol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used to treat stroke?. ### Response: Paracetamol.


Instruction: How many strokes were there in 2014?

Output: 855–860

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes were there in 2014?. ### Response: 855–860.


Instruction: What was the most common cause of intracerebral hemorrhage?

Output: increased blood pressure levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the most common cause of intracerebral hemorrhage?. ### Response: increased blood pressure levels.


Instruction: What is the temporal profile of body temperature in acute ischemic stroke: relation to stroke severity and outcome?

Output: Karaszewski B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the temporal profile of body temperature in acute ischemic stroke: relation to stroke severity and outcome?. ### Response: Karaszewski B.


Instruction: What does BMC Neurol. 2012;12:123?

Output: Temporal profile of body temperature

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does BMC Neurol. 2012;12:123?. ### Response: Temporal profile of body temperature.


Instruction: How is an early rise in body temperature related to unfavorable outcome after stroke?

Output: related to unfavorable outcome after stroke: data from the PAIS study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is an early rise in body temperature related to unfavorable outcome after stroke?. ### Response: related to unfavorable outcome after stroke: data from the PAIS study.


Instruction: What did the PAIS study do?

Output: An early rise in body temperature is related to unfavorable outcome after stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the PAIS study do?. ### Response: An early rise in body temperature is related to unfavorable outcome after stroke.


Instruction: What is a bicenter prospective, randomized trial in ICU patients with severe cerebrovascular disease?

Output: Paracetamol (Acetaminophen) In Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a bicenter prospective, randomized trial in ICU patients with severe cerebrovascular disease?. ### Response: Paracetamol (Acetaminophen) In Stroke.


Instruction: What is the name of the study that randomized patients to a long-term normothermia?

Output: PAIS study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that randomized patients to a long-term normothermia?. ### Response: PAIS study.


Instruction: How many strokes were reported in 2009?

Output: 40:e657–e665

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes were reported in 2009?. ### Response: 40:e657–e665.


Instruction: What is the name of the phase III trial of Acetaminophen in Stroke?

Output: The Paracetamol (Acetaminophen) In Stroke (PAIS) trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the phase III trial of Acetaminophen in Stroke?. ### Response: The Paracetamol (Acetaminophen) In Stroke (PAIS) trial.


Instruction: How many patients were enrolled in the PAIS trial?

Output: multicen-tre, randomised, placebo-controlled, phase III trial. Lancet Neurol. 2009;8:434–440

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were enrolled in the PAIS trial?. ### Response: multicen-tre, randomised, placebo-controlled, phase III trial. Lancet Neurol. 2009;8:434–440.


Instruction: What was the outcome of the Phase III study?

Output: randomised, placebo-controlled

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome of the Phase III study?. ### Response: randomised, placebo-controlled.


Instruction: What does ReCCLAIM I stand for?

Output: Endovascular Reperfusion and Cooling in Cerebral Acute Ischemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ReCCLAIM I stand for?. ### Response: Endovascular Reperfusion and Cooling in Cerebral Acute Ischemia.


Instruction: What is Endovascular Reperfusion and Cooling in?

Output: Cerebral Acute Ischemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Endovascular Reperfusion and Cooling in?. ### Response: Cerebral Acute Ischemia.


Instruction: What is the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al 2020 ACC/AHA Guideline for the Management of Valvular Heart DiseaseCirculation. 2021;143:e72–e227

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al 2020 ACC/AHA Guideline for the Management of Valvular Heart DiseaseCirculation. 2021;143:e72–e227.


Instruction: What is a noninvasive evaluation of mitral regurgitation by analysis of left atrial signal loss in cine magnetic resonance?

Output: Pflugfelder PW, Sechtem UP , White RD, et al. Noninvasive evaluation of mitral regurgitation by analysis of left atrial signal loss in cine magnetic resonance. Am Heart J. 1989;117:1113–9. 8. Myerson SG, d’Arcy J, Christiansen JP , et al. Determination of clinical outcome in mitral regurgitation with cardiovascular magnetic resonance quantification. Circulation. 2016;133:2287–96. 9. Zoghbi WA, Adams D, Bonow RO, et al. Recommendations for noninvasive evaluation of native valvular regurgitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a noninvasive evaluation of mitral regurgitation by analysis of left atrial signal loss in cine magnetic resonance?. ### Response: Pflugfelder PW, Sechtem UP , White RD, et al. Noninvasive evaluation of mitral regurgitation by analysis of left atrial signal loss in cine magnetic resonance. Am Heart J. 1989;117:1113–9. 8. Myerson SG, d’Arcy J, Christiansen JP , et al. Determination of clinical outcome in mitral regurgitation with cardiovascular magnetic resonance quantification. Circulation. 2016;133:2287–96. 9. Zoghbi WA, Adams D, Bonow RO, et al. Recommendations for noninvasive evaluation of native valvular regurgitation.


Instruction: What is the name of the technique used to analyze left atrial signal loss?

Output: cine magnetic resonance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the technique used to analyze left atrial signal loss?. ### Response: cine magnetic resonance.


Instruction: What is one of the results of the cine magnetic resonance analysis?

Output: Determination of clinical outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the results of the cine magnetic resonance analysis?. ### Response: Determination of clinical outcome.


Instruction: How is clinical outcome measured in mitral regurgitation?

Output: cardiovascular magnetic resonance quantification

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is clinical outcome measured in mitral regurgitation?. ### Response: cardiovascular magnetic resonance quantification.


Instruction: Who developed the recommendations for noninvasive evaluation of native valvular regurgitation?

Output: American Society of Echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who developed the recommendations for noninvasive evaluation of native valvular regurgitation?. ### Response: American Society of Echocardiography.


Instruction: What was developed in collaboration with the Society for Cardio-vascular Magnetic Resonance?

Output: Recommendations for noninvasive evaluation of native valvular regurgitation: a report from the American Society of Echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was developed in collaboration with the Society for Cardio-vascular Magnetic Resonance?. ### Response: Recommendations for noninvasive evaluation of native valvular regurgitation: a report from the American Society of Echocardiography.


Instruction: What type of echocardiogra-phy is used in intraoperative evaluation of recon-struction of the atrioventricular valves?

Output: transesophageal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of echocardiogra-phy is used in intraoperative evaluation of recon-struction of the atrioventricular valves?. ### Response: transesophageal.


Instruction: What year did Thorac Cardiovasc Surg issue 35(Spec No. 2):140–2?

Output: 1987

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Thorac Cardiovasc Surg issue 35(Spec No. 2):140–2?. ### Response: 1987.


Instruction: How does TEE predict early and late postoperative mitral valve dys-function?

Output: Intraoperative TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does TEE predict early and late postoperative mitral valve dys-function?. ### Response: Intraoperative TEE.


Instruction: What predicts early and late postoperative mitral valve dys-function?

Output: Intraoperative TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What predicts early and late postoperative mitral valve dys-function?. ### Response: Intraoperative TEE.


Instruction: What is part 2 of European Association of Echocar -diography recommendations for the assessment of valvular regurgitation?

Output: mitral and tricuspid regurgitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is part 2 of European Association of Echocar -diography recommendations for the assessment of valvular regurgitation?. ### Response: mitral and tricuspid regurgitation.


Instruction: What is regurgitation?

Output: native valve disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is regurgitation?. ### Response: native valve disease.


Instruction: When did Eur J Echo-cardiogr. 2010 issue 11:307-32?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Eur J Echo-cardiogr. 2010 issue 11:307-32?. ### Response: 2010.


Instruction: What is the name of the disease that causes native valve disease?

Output: mitral and tricuspid regurgitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease that causes native valve disease?. ### Response: mitral and tricuspid regurgitation.


Instruction: Who was the author of Valvular heart disease in 1997?

Output: Carabello BA, Crawford FA Jr

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the author of Valvular heart disease in 1997?. ### Response: Carabello BA, Crawford FA Jr.


Instruction: In what year was N Engl J Med published?

Output: 1997

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was N Engl J Med published?. ### Response: 1997.


Instruction: What is the rationale for optimizing surgical indications?

Output: Impact of preoperative symptoms on survival after surgical correction of organic mitral regurgitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the rationale for optimizing surgical indications?. ### Response: Impact of preoperative symptoms on survival after surgical correction of organic mitral regurgitation.


Instruction: When did Circulation. 1999:400–5?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circulation. 1999:400–5?. ### Response: 1999.


Instruction: What should patients with severe degenerative mitral regurgitation delay surgery until symptoms develop?

Output: 15

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients with severe degenerative mitral regurgitation delay surgery until symptoms develop?. ### Response: 15.


Instruction: What did Schaff HV, AJ, Schuler G, Peterson KL, Johnson A, et al. do after surgical correction of organic mitral regurgitation?

Output: Impact of preoperative symptoms on survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Schaff HV, AJ, Schuler G, Peterson KL, Johnson A, et al. do after surgical correction of organic mitral regurgitation?. ### Response: Impact of preoperative symptoms on survival.


Instruction: What was the temporal response of left ventricular performance to mitral valve surgery?

Output: dys-function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the temporal response of left ventricular performance to mitral valve surgery?. ### Response: dys-function.


Instruction: What is standardization of adult transthoracic echocardiography reporting in agreement with recent chamber quantification, diastolic function, and heart valve disease recommendations?

Output: an expert con-sensus document of the European Association of Cardiovascular Imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is standardization of adult transthoracic echocardiography reporting in agreement with recent chamber quantification, diastolic function, and heart valve disease recommendations?. ### Response: an expert con-sensus document of the European Association of Cardiovascular Imaging.


Instruction: What is an expert con-senus document of the European Association of Cardiovascular Imaging?

Output: Standardization of adult transthoracic echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an expert con-senus document of the European Association of Cardiovascular Imaging?. ### Response: Standardization of adult transthoracic echocardiography.


Instruction: What is the most recent issue of Heart J Cardiovasc Imaging?

Output: Eur

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most recent issue of Heart J Cardiovasc Imaging?. ### Response: Eur.


Instruction: What are the names of the authors of the study?

Output: Dahm M, Iversen S, Schmid FX

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the authors of the study?. ### Response: Dahm M, Iversen S, Schmid FX.


Instruction: How does contrast enhancement and image quality affect two- and three-dimensional echocardiographic determi-cations?

Output: Jenner J

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does contrast enhancement and image quality affect two- and three-dimensional echocardiographic determi-cations?. ### Response: Jenner J.


Instruction: What is another name for Surgery Study II366?

Output: Angioplasty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for Surgery Study II366?. ### Response: Angioplasty.


Instruction: What is the acronym for Synergy between Percutaneous Coronary Intervention with TAXUS andCardiac Surgery?

Output: SYNTAX

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Synergy between Percutaneous Coronary Intervention with TAXUS andCardiac Surgery?. ### Response: SYNTAX.


Instruction: Ezetimibe added to statin therapy after acute coronary syndromes.

Output: Cannon CP , Blazing MA, Giugliano RP , et al. Ezetimibe added to statin therapy after acute coronary syndromes. N Engl J Med. 2015;372:2387–97

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Ezetimibe added to statin therapy after acute coronary syndromes.. ### Response: Cannon CP , Blazing MA, Giugliano RP , et al. Ezetimibe added to statin therapy after acute coronary syndromes. N Engl J Med. 2015;372:2387–97.


Instruction: What is the name of the drug that has been added to the statin treatment?

Output: Ezetimibe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug that has been added to the statin treatment?. ### Response: Ezetimibe.


Instruction: What does simvastatin do to lower LDL cholesterol in patients with chronic kidney disease?

Output: The effects of lowering LDL cholesterol with simvastatin plus ezetimibe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does simvastatin do to lower LDL cholesterol in patients with chronic kidney disease?. ### Response: The effects of lowering LDL cholesterol with simvastatin plus ezetimibe.


Instruction: What is the name of the randomised placebo-controlled trial of simvastatin and ezetimibe in patients with chronic kidney disease?

Output: Study of Heart and Renal Protection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised placebo-controlled trial of simvastatin and ezetimibe in patients with chronic kidney disease?. ### Response: Study of Heart and Renal Protection.


Instruction: What is a risk factor for cardiovascular events in type 2 diabetes?

Output: Lower extremity peripheral arterial disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for cardiovascular events in type 2 diabetes?. ### Response: Lower extremity peripheral arterial disease.


Instruction: What type of diabetes is more dangerous and lethal than type 1 diabetes?

Output: type 2 dia-betes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diabetes is more dangerous and lethal than type 1 diabetes?. ### Response: type 2 dia-betes.


Instruction: What is the association of type 2 diabetes mel-litus with?

Output: coronary heart disease and stroke risks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association of type 2 diabetes mel-litus with?. ### Response: coronary heart disease and stroke risks.


Instruction: What type of diabetes is associated with complications during teenage years and young adulthood?

Output: type 1 diabetes vs type 2 diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diabetes is associated with complications during teenage years and young adulthood?. ### Response: type 1 diabetes vs type 2 diabetes.


Instruction: What is the name of the systematic review of the association between dia-betic retinopathy and cardiovascular disease?

Output: Prospective

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review of the association between dia-betic retinopathy and cardiovascular disease?. ### Response: Prospective.


Instruction: What is a prospective association between dia-betic retinopathy and cardiovascular disease?

Output: —a systematic review and meta-analysis of cohort studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a prospective association between dia-betic retinopathy and cardiovascular disease?. ### Response: —a systematic review and meta-analysis of cohort studies.


Instruction: What is the J Stroke Cerebrovasc Dis. 2016;25:1688-95?

Output: Prospective association between dia-betic retinopathy and cardiovascular disease—a systematic review and meta-analysis of cohort studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the J Stroke Cerebrovasc Dis. 2016;25:1688-95?. ### Response: Prospective association between dia-betic retinopathy and cardiovascular disease—a systematic review and meta-analysis of cohort studies.


Instruction: How is risk of non-fatal cardiovascular diseases in early-onset versus late-onset type 2 diabetes in China?

Output: cross-sectional study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is risk of non-fatal cardiovascular diseases in early-onset versus late-onset type 2 diabetes in China?. ### Response: cross-sectional study.


Instruction: What is the name of the cross-sectional study of diabetes in China?

Output: Risk of non-fatal cardiovascular diseases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the cross-sectional study of diabetes in China?. ### Response: Risk of non-fatal cardiovascular diseases.


Instruction: What was the title of the study?

Output: Study of Heart and Renal Protection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the title of the study?. ### Response: Study of Heart and Renal Protection.


Instruction: How did Nezarat N, Budoff MJ, Luo Y, et al. determine the presence, characteristics, and volumes of coronary plaque?

Output: computed tomogra-phy angiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Nezarat N, Budoff MJ, Luo Y, et al. determine the presence, characteristics, and volumes of coronary plaque?. ### Response: computed tomogra-phy angiography.


Instruction: What year was the population study 'Men born in 1914' from Malmo, Sweden conducted?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the population study 'Men born in 1914' from Malmo, Sweden conducted?. ### Response: 2005.


Instruction: What is the name of the study?

Output: Study of Heart and Renal Protection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study?. ### Response: Study of Heart and Renal Protection.


Instruction: How old are 68 year old men with diabetes?

Output: 66–71

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old are 68 year old men with diabetes?. ### Response: 66–71.


Instruction: What is an independent predictor of type 1 diabetes complications?

Output: Peripheral neu-ropathy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an independent predictor of type 1 diabetes complications?. ### Response: Peripheral neu-ropathy.


Instruction: What is the Pittsburgh Epidemiology of Diabetes Complications Study experience?

Output: 30-year natural history of type 1 diabetes complications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Pittsburgh Epidemiology of Diabetes Complications Study experience?. ### Response: 30-year natural history of type 1 diabetes complications.


Instruction: Diabetes. 2006;55:1463–9.

Output: Pittsburgh Epidemiology of Diabetes Complications Study experience

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Diabetes. 2006;55:1463–9.. ### Response: Pittsburgh Epidemiology of Diabetes Complications Study experience.


Instruction: What is an independent predictor of coronary heart disease and stroke risks in patients with type 2 diabetes mellitus in China?

Output: Lower extremity peripheral arterial disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an independent predictor of coronary heart disease and stroke risks in patients with type 2 diabetes mellitus in China?. ### Response: Lower extremity peripheral arterial disease.


Instruction: What is albuminuria and renal function as predictors of?

Output: cardiovascular events and mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is albuminuria and renal function as predictors of?. ### Response: cardiovascular events and mortality.


Instruction: What predictors cardiovascular events and mortality in a general population of patients with type 2 diabetes?

Output: Albuminuria and renal function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What predictors cardiovascular events and mortality in a general population of patients with type 2 diabetes?. ### Response: Albuminuria and renal function.


Instruction: What is the name of the nationwide observational study from the Swedish National Diabetes Register?

Output: Svensson MK, Cederholm J, Eliasson B, et al. Albuminuria and renal function as predictors of cardiovascular events and mortality in a general population of patients with type 2 diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the nationwide observational study from the Swedish National Diabetes Register?. ### Response: Svensson MK, Cederholm J, Eliasson B, et al. Albuminuria and renal function as predictors of cardiovascular events and mortality in a general population of patients with type 2 diabetes.


Instruction: What is primary prevention with statin therapy in the elderly?

Output: new meta-analyses from the con-temporary JUPITER and HOPE-3 randomized trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is primary prevention with statin therapy in the elderly?. ### Response: new meta-analyses from the con-temporary JUPITER and HOPE-3 randomized trials.


Instruction: What are the contemporary JUPITER and HOPE-3 trials?

Output: S4.3-20

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the contemporary JUPITER and HOPE-3 trials?. ### Response: S4.3-20.


Instruction: What could have cost implications?

Output: recommendati ons

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could have cost implications?. ### Response: recommendati ons.


Instruction: What will incur an additional cost due to the required extra time from the clinician to fully explain the person’s diagnosis and prognosis?

Output: an extended first consultation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will incur an additional cost due to the required extra time from the clinician to fully explain the person’s diagnosis and prognosis?. ### Response: an extended first consultation.


Instruction: What did the committee feel was necessary for good clinical practice?

Output: a stand ard consultation appointment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee feel was necessary for good clinical practice?. ### Response: a stand ard consultation appointment.


Instruction: What is endorsed by the patient experience guideline?

Output: specifies that when discussing patient views and preferences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is endorsed by the patient experience guideline?. ### Response: specifies that when discussing patient views and preferences.


Instruction: What should be allowed when discussing patient views and preferences?

Output: adequate time

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be allowed when discussing patient views and preferences?. ### Response: adequate time.


Instruction: What did the meta-analyses show about PCI and CABG?

Output: similar survival rates in these patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the meta-analyses show about PCI and CABG?. ### Response: similar survival rates in these patients.


Instruction: What is another name for proximal LAD artery disease?

Output: GDMT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for proximal LAD artery disease?. ### Response: GDMT.


Instruction: How do most patients undergoing CABG receive revascularization?

Output: complete or nearlycomplete

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do most patients undergoing CABG receive revascularization?. ### Response: complete or nearlycomplete.


Instruction: What does CABG receive that seems to influence long-term prognosis positively?

Output: complete or nearlycomplete revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CABG receive that seems to influence long-term prognosis positively?. ### Response: complete or nearlycomplete revascularization.


Instruction: When is complete revascu-larization accomplished less often in subjects receiving PCI?

Output: /H1102170% of patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is complete revascu-larization accomplished less often in subjects receiving PCI?. ### Response: /H1102170% of patients.


Instruction: The extent to which the absence of complete initial revascularization influences outcome is not clear what?

Output: better survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The extent to which the absence of complete initial revascularization influences outcome is not clear what?. ### Response: better survival.


Instruction: What are rates of late survival and survival free of?

Output: MI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are rates of late survival and survival free of?. ### Response: MI.


Instruction: What are the rates of late survival and survival free of MI?

Output: similar

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the rates of late survival and survival free of MI?. ### Response: similar.


Instruction: What is the need for subsequent CABG in those whose initial revas-cularization procedure was incomplete?

Output: higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the need for subsequent CABG in those whose initial revas-cularization procedure was incomplete?. ### Response: higher.


Instruction: What did older studies show about patients with LV systolic dysfunc-tion?

Output: better survival with CABG than with medical therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did older studies show about patients with LV systolic dysfunc-tion?. ### Response: better survival with CABG than with medical therapy.


Instruction: What type of patients had better survival with CABG than with medical therapy?

Output: patients with LV systolic dysfunc-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of patients had better survival with CABG than with medical therapy?. ### Response: patients with LV systolic dysfunc-tion.


Instruction: What is lacking for patients with more severe LV systolicdysfunction?

Output: the evidence that CABG results inbetter survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is lacking for patients with more severe LV systolicdysfunction?. ### Response: the evidence that CABG results inbetter survival.


Instruction: What did the STICH trial of subjects with LVEF/H1102135% with or withoutviability testing show?

Output: similar ratesof survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the STICH trial of subjects with LVEF/H1102135% with or withoutviability testing show?. ### Response: similar ratesof survival.


Instruction: After how long did GDMT and CABG result in similar rates of survival?

Output: 5 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: After how long did GDMT and CABG result in similar rates of survival?. ### Response: 5 years.


Instruction: What is the primary outcome of a study?

Output: death from any cause

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary outcome of a study?. ### Response: death from any cause.


Instruction: How long does it take to survive?

Output: 5 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take to survive?. ### Response: 5 years.


Instruction: What is a secondary outcome after 5 years of follow up?

Output: death from any cause

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a secondary outcome after 5 years of follow up?. ### Response: death from any cause.


Instruction: What was superior to GDMT?

Output: CABG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was superior to GDMT?. ### Response: CABG.


Instruction: What was the primary out-come after 5 years of follow-up?

Output: death from any cause

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary out-come after 5 years of follow-up?. ### Response: death from any cause.


Instruction: How many years of follow-up does the study have?

Output: 5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many years of follow-up does the study have?. ### Response: 5.


Instruction: How long is the study continuing?

Output: up to 10 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the study continuing?. ### Response: up to 10 years.


Instruction: What is the only data available comparing PCI with medicaltherapy?

Output: patients with LV systolic dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the only data available comparing PCI with medicaltherapy?. ### Response: patients with LV systolic dysfunction.


Instruction: What is avail-able in patients with LV systolic dysfunction?

Output: very limited data comparing PCI with medicaltherapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is avail-able in patients with LV systolic dysfunction?. ### Response: very limited data comparing PCI with medicaltherapy.


Instruction: What are some studies comparing with CABG and balloon angioplasty?

Output: many were retrospective

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some studies comparing with CABG and balloon angioplasty?. ### Response: many were retrospective.


Instruction: What is the rate of revascularization in patients with CAD and LV systolic dysfunction?

Output: 964

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the rate of revascularization in patients with CAD and LV systolic dysfunction?. ### Response: 964.


Instruction: What was the rate in patients having CABG and PCI?

Output: similarsurvival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the rate in patients having CABG and PCI?. ### Response: similarsurvival.


Instruction: What determines the optimal strategy?

Output: severity/complexity, and risk of contrast nephropathy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What determines the optimal strategy?. ### Response: severity/complexity, and risk of contrast nephropathy.


Instruction: What is the strategy of routine PCI of noninfarct related arteries in hemodynamically stable patients?

Output: optimal strategy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the strategy of routine PCI of noninfarct related arteries in hemodynamically stable patients?. ### Response: optimal strategy.


Instruction: What type of patients have spontaneous symptoms andmyocardial ischemia?

Output: hemodynamically stable patients. Recommendations inthe 2013 STEMI guideline with regard to PCI of a non –infarct-related artery at a time separate from primary PCIin patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of patients have spontaneous symptoms andmyocardial ischemia?. ### Response: hemodynamically stable patients. Recommendations inthe 2013 STEMI guideline with regard to PCI of a non –infarct-related artery at a time separate from primary PCIin patients.


Instruction: What are patients who have intermediate- or high-riskfindings on noninvasive testing?

Output: patients who have spontaneous symptoms andmyocardial ischemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients who have intermediate- or high-riskfindings on noninvasive testing?. ### Response: patients who have spontaneous symptoms andmyocardial ischemia.


Instruction: What may be asso ciated with better outcomethan multivessel staged PCI?

Output: multi-vessel staged PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be asso ciated with better outcomethan multivessel staged PCI?. ### Response: multi-vessel staged PCI.


Instruction: There are insuf ficientobservational data and no randomized data at this time to inform a recommendation with regard to the optimaltiming of what?

Output: nonculprit vessel PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There are insuf ficientobservational data and no randomized data at this time to inform a recommendation with regard to the optimaltiming of what?. ### Response: nonculprit vessel PCI.


Instruction: Additional trial data that will help clarify this issue are awaited.

Output: T h r e emulticenter trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Additional trial data that will help clarify this issue are awaited.. ### Response: T h r e emulticenter trials.


Instruction: What are issues related to the optimal method of evaluating nonculpritlesions beyond the scope of this focused update?

Output: percent diam eter stenosis, fractional ﬂowreserve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are issues related to the optimal method of evaluating nonculpritlesions beyond the scope of this focused update?. ### Response: percent diam eter stenosis, fractional ﬂowreserve.


Instruction: How many RCTs did the 2011 PCI and 2013 STEMI guidelines have?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs did the 2011 PCI and 2013 STEMI guidelines have?. ### Response: 2.


Instruction: How manymeta-analysis were there?

Output: 13

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How manymeta-analysis were there?. ### Response: 13.


Instruction: What was the recommendation for aspiration thrombectomy before pri-mary PCI?

Output: Class II

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the recommendation for aspiration thrombectomy before pri-mary PCI?. ### Response: Class II.


Instruction: What is TAPAS?

Output: Thrombus Aspiration During PrimaryPercutaneous Coronary Interv ention in Acute MyocardialInfarction Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is TAPAS?. ### Response: Thrombus Aspiration During PrimaryPercutaneous Coronary Interv ention in Acute MyocardialInfarction Study.


Instruction: How many patients with STEMI were randomized to aspiration thrombectomyb?

Output: 1071

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with STEMI were randomized to aspiration thrombectomyb?. ### Response: 1071.


Instruction: How many patients were enrolled in the INFUSE-AMI trial?

Output: 452

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were enrolled in the INFUSE-AMI trial?. ### Response: 452.


Instruction: What is the name of the multicenter trial that enrolled significally more patients than prior aspiration thrombectomy trials?

Output: INFUSE-AMI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multicenter trial that enrolled significally more patients than prior aspiration thrombectomy trials?. ### Response: INFUSE-AMI.


Instruction: What is the name of the intracoronary abciximab and aspiration thrombectomy in patients with large anterior myocardial infarction trial?

Output: INFUSE-AMI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the intracoronary abciximab and aspiration thrombectomy in patients with large anterior myocardial infarction trial?. ### Response: INFUSE-AMI.


Instruction: How many patients in the INFUSE-AMI trial had anterior STEMIdue to proximal or mid-left anterior descending occlusion?

Output: 452

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients in the INFUSE-AMI trial had anterior STEMIdue to proximal or mid-left anterior descending occlusion?. ### Response: 452.


Instruction: How many patients wereenrolled in the Elevation Myocardial Infarction trial?

Output: 452 patients with anterior STEMIdue to proximal or mid-left anterior descending occlusion,infarct size was not reduced by aspiration thrombectomybefore primary PCI. The TASTE (Thrombus AspirationDuring ST-Segment Elevation Myocardial Infarction) trial(n¼7,244

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients wereenrolled in the Elevation Myocardial Infarction trial?. ### Response: 452 patients with anterior STEMIdue to proximal or mid-left anterior descending occlusion,infarct size was not reduced by aspiration thrombectomybefore primary PCI. The TASTE (Thrombus AspirationDuring ST-Segment Elevation Myocardial Infarction) trial(n¼7,244.


Instruction: How long did the difference between the group that receivedaspiration thrombectomy before primary PCI and thegroup that did not?

Output: 30-day

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the difference between the group that receivedaspiration thrombectomy before primary PCI and thegroup that did not?. ### Response: 30-day.


Instruction: What type of design allowed randomization within an existing national registry?

Output: unique

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of design allowed randomization within an existing national registry?. ### Response: unique.


Instruction: What type of thrombectomy did a group receive before primary PCI?

Output: aspiration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of thrombectomy did a group receive before primary PCI?. ### Response: aspiration.


Instruction: What is the TOTAL (Trial of R outine Aspiration Thrombectomy)?

Output: primary PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the TOTAL (Trial of R outine Aspiration Thrombectomy)?. ### Response: primary PCI.


Instruction: What is a relationship considered to be if it is less than "significant"?

Output: modest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a relationship considered to be if it is less than "significant"?. ### Response: modest.


Instruction: How much of the fair market value of the entity is considered a "modest" relationship?

Output: $10 000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the fair market value of the entity is considered a "modest" relationship?. ### Response: $10 000.


Instruction: What is the yearly rupture or dissection rates for thoracic aortic aneurysms based on?

Output: size

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the yearly rupture or dissection rates for thoracic aortic aneurysms based on?. ### Response: size.


Instruction: What is Masri A, Kalahasti V?

Output: 5. Masri A, Kalahasti V, Alkharabsheh S, et al. Characteristics and long-term outcomes of contemporary patients with bicuspid aortic valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Masri A, Kalahasti V?. ### Response: 5. Masri A, Kalahasti V, Alkharabsheh S, et al. Characteristics and long-term outcomes of contemporary patients with bicuspid aortic valves.


Instruction: What is the risk of aortic events in patients with bicuspid valves?

Output: Long-term risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of aortic events in patients with bicuspid valves?. ### Response: Long-term risk.


Instruction: What year did Am J Cardiol. 2010:106:1626–33?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Am J Cardiol. 2010:106:1626–33?. ### Response: 2010.


Instruction: Girdauskas E, Disha K, Borger MA, et al.

Output: 7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Girdauskas E, Disha K, Borger MA, et al.. ### Response: 7.


Instruction: What is the name of the valve that causes ascending aortic aneurysm?

Output: bicuspid aortic valve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the valve that causes ascending aortic aneurysm?. ### Response: bicuspid aortic valve.


Instruction: What type of valve stenosis is more likely to occur after valve replacement?

Output: bicus-pid aortic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of valve stenosis is more likely to occur after valve replacement?. ### Response: bicus-pid aortic.


Instruction: How many years has it been reported that a bicuspid versus tri-cuspid valve is better?

Output: 11

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many years has it been reported that a bicuspid versus tri-cuspid valve is better?. ### Response: 11.


Instruction: What is the name of the valve and rate of as-cending aortic dilatation?

Output: Congenital bicuspid aortic valve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the valve and rate of as-cending aortic dilatation?. ### Response: Congenital bicuspid aortic valve.


Instruction: When was the Am J Cardiol.93:525–6 published?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Am J Cardiol.93:525–6 published?. ### Response: 2004.


Instruction: What are the names of the authors of the study?

Output: Davies RR, Goldstein LJ, Coady MA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the authors of the study?. ### Response: Davies RR, Goldstein LJ, Coady MA.


Instruction: What is the fate of mild-to-moderate proximal aortic dilatation?

Output: after isolated aortic valve replacement for bicus-pid aortic valve stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the fate of mild-to-moderate proximal aortic dilatation?. ### Response: after isolated aortic valve replacement for bicus-pid aortic valve stenosis.


Instruction: What was the outcome of the magnetic resonance imaging follow-up study?

Output: mild-to-moderate proximal aortic dilatation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome of the magnetic resonance imaging follow-up study?. ### Response: mild-to-moderate proximal aortic dilatation.


Instruction: What is the name of the consensus guidelines on bicuspid aortic valve-related Aortopathy?

Output: The American Associa-tion for Thoracic Surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the consensus guidelines on bicuspid aortic valve-related Aortopathy?. ### Response: The American Associa-tion for Thoracic Surgery.


Instruction: What are the guidelines for patients with BAV5.1.2.1?

Output: Interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the guidelines for patients with BAV5.1.2.1?. ### Response: Interventions.


Instruction: Who is the author of The American Association for Thoracic Surgery?

Output: Borger

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of The American Association for Thoracic Surgery?. ### Response: Borger.


Instruction: What is a systematic review of contemporary natural history of bi-cuspid aortic valve disease?

Output: Heart

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a systematic review of contemporary natural history of bi-cuspid aortic valve disease?. ### Response: Heart.


Instruction: What are the 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for?

Output: the diagnosis and management of patients with thoracic aortic disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for?. ### Response: the diagnosis and management of patients with thoracic aortic disease.


Instruction: What type of disease is associated with thoracic aortic disease?

Output: bi-cuspid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of disease is associated with thoracic aortic disease?. ### Response: bi-cuspid.


Instruction: The American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines issued a report on what?

Output: Guidelines for the diagnosis and management of patients with thoracic aortic disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines issued a report on what?. ### Response: Guidelines for the diagnosis and management of patients with thoracic aortic disease.


Instruction: American Stroke Association, Society of Cardiovascular An-esthesiologists, Society for Cardiovascular Angiography and Interventions and Society of Interventional Radiology were among the organizations that produced the report.

Output: American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: American Stroke Association, Society of Cardiovascular An-esthesiologists, Society for Cardiovascular Angiography and Interventions and Society of Interventional Radiology were among the organizations that produced the report.. ### Response: American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.


Instruction: What is the name of the Society of Interventional Radiology?

Output: Society for Cardiovascular Angiography and Interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Society of Interventional Radiology?. ### Response: Society for Cardiovascular Angiography and Interventions.


Instruction: What are the names of Society of Thoracic Surgeons and Soci-ety for Vascular Medicine?

Output: Society of Interventional Radiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of Society of Thoracic Surgeons and Soci-ety for Vascular Medicine?. ### Response: Society of Interventional Radiology.


Instruction: When did J Am Coll Cardiol. 2010 issue 55:e27-129?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J Am Coll Cardiol. 2010 issue 55:e27-129?. ### Response: 2010.


Instruction: Where did Elefteriades come from?

Output: 10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where did Elefteriades come from?. ### Response: 10.


Instruction: What is the yearly rupture or dissection rates for thoracic aortic aneurysms?

Output: simple prediction based on size

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the yearly rupture or dissection rates for thoracic aortic aneurysms?. ### Response: simple prediction based on size.


Instruction: What is a simple prediction based on size?

Output: Yearly rupture or dissection rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a simple prediction based on size?. ### Response: Yearly rupture or dissection rates.


Instruction: What is the name of the 2021 guideline for the secondary prevention of Ischemic Stroke?

Output: 2021 Guideline for the Secondary Prevention of Ischemic StrokeTicagrelor and ASA for Prevention of Stroke and Death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2021 guideline for the secondary prevention of Ischemic Stroke?. ### Response: 2021 Guideline for the Secondary Prevention of Ischemic StrokeTicagrelor and ASA for Prevention of Stroke and Death.


Instruction: What are the names of the two drugs discussed in more detail in Section 5.19, Use of Antithrombotic Medications in secondary stroke prevention?

Output: ticagrelor and aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the two drugs discussed in more detail in Section 5.19, Use of Antithrombotic Medications in secondary stroke prevention?. ### Response: ticagrelor and aspirin.


Instruction: What is the risk of recurrent stroke or death at 30 days among patients with 30% intracranial stenosis ipsilateral to the ischemic territory?

Output: 9.9%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of recurrent stroke or death at 30 days among patients with 30% intracranial stenosis ipsilateral to the ischemic territory?. ### Response: 9.9%.


Instruction: What are the recommendations for short-term treatment with combination ticagrelor and aspirin?

Output: loading doses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the recommendations for short-term treatment with combination ticagrelor and aspirin?. ### Response: loading doses.


Instruction: What percentage of patients had 30% intracranial stenosis ipsilateral to the ischemic event?

Output: 9.9%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients had 30% intracranial stenosis ipsilateral to the ischemic event?. ### Response: 9.9%.


Instruction: What was the HR of the ticagrelor 90 mg twice daily plus aspirin 100 mg once a day group?

Output: 0.66

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the HR of the ticagrelor 90 mg twice daily plus aspirin 100 mg once a day group?. ### Response: 0.66.


Instruction: What was the HR of THALES patients without atherosclerosis?

Output: 0.66

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the HR of THALES patients without atherosclerosis?. ### Response: 0.66.


Instruction: What was not significantly higher in the ipsilateral atherosclerosis subgroup treated with ticagrelor and aspirin than in those taking aspirine alone?

Output: bleeding events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not significantly higher in the ipsilateral atherosclerosis subgroup treated with ticagrelor and aspirin than in those taking aspirine alone?. ### Response: bleeding events.


Instruction: What were the loading doses of both ticagre-lor and aspirin?

Output: 90 mg twice a day

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the loading doses of both ticagre-lor and aspirin?. ### Response: 90 mg twice a day.


Instruction: What was not required to be related to the index isch-emic event?

Output: ICAS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not required to be related to the index isch-emic event?. ### Response: ICAS.


Instruction: What is the role of genetic studies or platelet function testing?

Output: unclear

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of genetic studies or platelet function testing?. ### Response: unclear.


Instruction: What has been studied in RCTs?

Output: the efficacy of cilo-stazol 200 mg/d combined with other antiplate-let agents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been studied in RCTs?. ### Response: the efficacy of cilo-stazol 200 mg/d combined with other antiplate-let agents.


Instruction: Several RCTs have studied the efficacy of cilo-stazol 200 mg/d combined with what other antiplate-let agent in patients with symptomatic ICAS?

Output: aspirin or clopidogrel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Several RCTs have studied the efficacy of cilo-stazol 200 mg/d combined with what other antiplate-let agent in patients with symptomatic ICAS?. ### Response: aspirin or clopidogrel.


Instruction: The TOSS-1 and TOSS-2 trials found that what was as safe as aspirin alone?

Output: cilostazol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The TOSS-1 and TOSS-2 trials found that what was as safe as aspirin alone?. ### Response: cilostazol.


Instruction: What was as safe as clopidogrel plus aspirin?

Output: cilostazol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was as safe as clopidogrel plus aspirin?. ### Response: cilostazol.


Instruction: What was no better for stroke prevention in patients with ICAS?

Output: aspirin alone or clopidogrel plus aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was no better for stroke prevention in patients with ICAS?. ### Response: aspirin alone or clopidogrel plus aspirin.


Instruction: The CATHARSIS trial reported that the combination of cilostazol and what other drug was superior to?

Output: aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The CATHARSIS trial reported that the combination of cilostazol and what other drug was superior to?. ### Response: aspirin.


Instruction: What was superior to aspirin for the prevention of the combined sec-ondary end point of all vascular events and new silent brain infarcts?

Output: cilostazol and aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was superior to aspirin for the prevention of the combined sec-ondary end point of all vascular events and new silent brain infarcts?. ### Response: cilostazol and aspirin.


Instruction: What percentage of patients with ICAS had no impact on ICAS progression?

Output: 10.7% versus 25%; P =0.04) but had no impact on ICAS progression.343

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients with ICAS had no impact on ICAS progression?. ### Response: 10.7% versus 25%; P =0.04) but had no impact on ICAS progression.343.


Instruction: What did the CSPS trial report?

Output: lower rate of stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the CSPS trial report?. ### Response: lower rate of stroke.


Instruction: What was the rate of stroke in patients with ICAS who were randomized to cilostazol plus aspirin or clopidogrel (dual group)?

Output: lower

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the rate of stroke in patients with ICAS who were randomized to cilostazol plus aspirin or clopidogrel (dual group)?. ### Response: lower.


Instruction: What was the 95% confidence interval between aspirin and cilostazol?

Output: 0.23–0.95

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 95% confidence interval between aspirin and cilostazol?. ### Response: 0.23–0.95.


Instruction: What population were the trials conducted in?

Output: Asian

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What population were the trials conducted in?. ### Response: Asian.


Instruction: How much did the dose of apirin when used in a com-bination?

Output: 150 mg/d

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much did the dose of apirin when used in a com-bination?. ### Response: 150 mg/d.


Instruction: What year did e106 Hypertension take place?

Output: 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did e106 Hypertension take place?. ### Response: 2018.


Instruction: What is the name of the study that examined the effects of nurse-managed protocols in the outpatient management of adults with chronic conditions?

Output: a systematic review and meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined the effects of nurse-managed protocols in the outpatient management of adults with chronic conditions?. ### Response: a systematic review and meta-analysis.


Instruction: How many pages did Ann Intern Med 2014 issue?

Output: 161:113–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many pages did Ann Intern Med 2014 issue?. ### Response: 161:113–.


Instruction: What is the name of the community-based, multifaceted intervention to improve blood pressure control?

Output: Thomas KL, Shah BR, Elliot-Bynum S, et al. Check it, change it

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the community-based, multifaceted intervention to improve blood pressure control?. ### Response: Thomas KL, Shah BR, Elliot-Bynum S, et al. Check it, change it.


Instruction: What are the results of the cluster-randomized trial of a physician/pharmacist collaborative model?

Output: improve blood pres-sure control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of the cluster-randomized trial of a physician/pharmacist collaborative model?. ### Response: improve blood pres-sure control.


Instruction: What is a collaborative model to improve blood pres-sure control?

Output: physician/pharmacist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a collaborative model to improve blood pres-sure control?. ### Response: physician/pharmacist.


Instruction: What is the name of the guide to community preventive services?

Output: The Community Guide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the guide to community preventive services?. ### Response: The Community Guide.


Instruction: When did Himmelfarb CRD, Commodore-Mensah Y, Hill MN publish their findings?

Output: June 1, 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Himmelfarb CRD, Commodore-Mensah Y, Hill MN publish their findings?. ### Response: June 1, 2017.


Instruction: What is the name of the organization that recommends team-based care for improving blood pressure control?

Output: Centers for Disease Control and Prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that recommends team-based care for improving blood pressure control?. ### Response: Centers for Disease Control and Prevention.


Instruction: When was Cardiovascular Disease: Team-Based Care to Improve Blood Pressure Control released?

Output: May 15, 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Cardiovascular Disease: Team-Based Care to Improve Blood Pressure Control released?. ### Response: May 15, 2012.


Instruction: Where is the Community Guide located?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the Community Guide located?. ### Response: https://www.thecom-munityguide.org.


Instruction: What year was the Task Force recom-mends team based care to improve blood pressure?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the Task Force recom-mends team based care to improve blood pressure?. ### Response: 2012.


Instruction: What is the name of the press release that was released on May 15, 2012?

Output: S12.2-10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the press release that was released on May 15, 2012?. ### Response: S12.2-10.


Instruction: When was this press release released?

Output: May 15, 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this press release released?. ### Response: May 15, 2012.


Instruction: What is one of the outcomes of the Multicenter Randomized Controlled RxEACH Trial?

Output: effectiveness of pharmacist interventions on cardiovascular risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the outcomes of the Multicenter Randomized Controlled RxEACH Trial?. ### Response: effectiveness of pharmacist interventions on cardiovascular risk.


Instruction: What is the name of the 2015 ACC health policy statement on cardiovascular team-based care and the role of community health workers in the care of people with hypertension?

Output: S12.2-10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2015 ACC health policy statement on cardiovascular team-based care and the role of community health workers in the care of people with hypertension?. ### Response: S12.2-10.


Instruction: What is the health policy statement on cardiovascular team-based care and the role of advanced practice providers?

Output: 2015 ACC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the health policy statement on cardiovascular team-based care and the role of advanced practice providers?. ### Response: 2015 ACC.


Instruction: What was the J Am Coll Cardiol 2015;65: 2118–36?

Output: 2015 ACC health policy statement on cardiovascular team-based care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the J Am Coll Cardiol 2015;65: 2118–36?. ### Response: 2015 ACC health policy statement on cardiovascular team-based care.


Instruction: Who is the Patient-Centered Primary Care Collaborative?

Output: The Patient-Centered Medical Home

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Patient-Centered Primary Care Collaborative?. ### Response: The Patient-Centered Medical Home.


Instruction: When was the Resource Guide released?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Resource Guide released?. ### Response: 2010.


Instruction: What year was medmanagement.pdf available?

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was medmanagement.pdf available?. ### Response: 2017.


Instruction: When was the document medManagement.pdf accessed?

Output: June 15, 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the document medManagement.pdf accessed?. ### Response: June 15, 2017.


Instruction: What is the role of the clinical pharmacist in the care of patients with cardiovascular disease?

Output: S12.2-15

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of the clinical pharmacist in the care of patients with cardiovascular disease?. ### Response: S12.2-15.


Instruction: What is the acronym for Strategies to Promote Hypertension Control?

Output: Health Information Technology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Strategies to Promote Hypertension Control?. ### Response: Health Information Technology.


Instruction: EHR and Patient Registries S12.3.1-1. Rakotz MK, Ewigman BG, Sarav M, et al. A technology-based quality innovation to identify undiagnosed hypertension among active primary care patients.

Output: Health Information Technology–Based Strategies to Promote Hypertension Control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: EHR and Patient Registries S12.3.1-1. Rakotz MK, Ewigman BG, Sarav M, et al. A technology-based quality innovation to identify undiagnosed hypertension among active primary care patients.. ### Response: Health Information Technology–Based Strategies to Promote Hypertension Control.


Instruction: What did Tang F, et al. consider the impact of the 2014 expert panel recommendations for management of high blood pressure?

Output: Impact

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Tang F, et al. consider the impact of the 2014 expert panel recommendations for management of high blood pressure?. ### Response: Impact.


Instruction: What is the second Randomised Intervention Treatment of Angina?

Output: RITA-2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the second Randomised Intervention Treatment of Angina?. ### Response: RITA-2.


Instruction: What was the name of the second RITA-2 trial?

Output: Randomised Intervention Treatment of Angina

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the second RITA-2 trial?. ### Response: Randomised Intervention Treatment of Angina.


Instruction: How long was the follow-up of the TIME trial in elderly patients?

Output: four-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the follow-up of the TIME trial in elderly patients?. ### Response: four-year.


Instruction: What is TIME?

Output: randomized Trial of Invasive versus Medical therapyin Elderly patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is TIME?. ### Response: randomized Trial of Invasive versus Medical therapyin Elderly patients.


Instruction: When was TIME published?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was TIME published?. ### Response: 2004.


Instruction: What is the effect of PCI on quality of life?

Output: patients with stable coronary disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of PCI on quality of life?. ### Response: patients with stable coronary disease.


Instruction: What type of cardiologists are board-eligible for CHD?

Output: Congenital cardiac surgeons

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of cardiologists are board-eligible for CHD?. ### Response: Congenital cardiac surgeons.


Instruction: What types of anesthesiologists have CHD training/expertise?

Output: Cardiac

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What types of anesthesiologists have CHD training/expertise?. ### Response: Cardiac.


Instruction: High-risk obstetrics Pulmonary hypertension HF/transplant Genetics Hepatology Cardiac pathology Rehabilitation services Social services Psychological services Financial counselors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: High-risk obstetrics Pulmonary hypertension HF/transplant Genetics Hepatology Cardiac pathology Rehabilitation services Social services Psychological services Financial counselors. ### Response: *:.


Instruction: What type of services are available to financial counselors?

Output: Psychological services

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of services are available to financial counselors?. ### Response: Psychological services.


Instruction: What are some of the modalities that must be used in CHD diagnostic and interventional catheterization?

Output: CHD electrophysiology/pacing/ICD implantation*:  Exercise testing  Echocardiographic  Radionuclide  Cardiopulmonary Cardiac imaging/radiology*:  CMR  CCT  Nuclear medicine Information technology:  Data collection  Database support  Quality assessment review/protocols

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the modalities that must be used in CHD diagnostic and interventional catheterization?. ### Response: CHD electrophysiology/pacing/ICD implantation*:  Exercise testing  Echocardiographic  Radionuclide  Cardiopulmonary Cardiac imaging/radiology*:  CMR  CCT  Nuclear medicine Information technology:  Data collection  Database support  Quality assessment review/protocols.


Instruction: What is the acronym for adult congenital heart disease?

Output: ACHD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for adult congenital heart disease?. ### Response: ACHD.


Instruction: What does CCT stand for?

Output: cardiac computed tomography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CCT stand for?. ### Response: cardiac computed tomography.


Instruction: CMR stands for what?

Output: cardiovascular magnetic resonance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: CMR stands for what?. ### Response: cardiovascular magnetic resonance.


Instruction: What is the acronym for implantable cardioverter-defibrillator?

Output: ICD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for implantable cardioverter-defibrillator?. ### Response: ICD.


Instruction: What is another name for transesophageal echocardiography?

Output: TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for transesophageal echocardiography?. ### Response: TEE.


Instruction: What indicates creatine kinase?

Output: CK

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates creatine kinase?. ### Response: CK.


Instruction: What does HIV stand for?

Output: human immunodeficiency virus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does HIV stand for?. ### Response: human immunodeficiency virus.


Instruction: HMGCR stands for what?

Output: 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: HMGCR stands for what?. ### Response: 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase.


Instruction: What is SASE?

Output: statin associated side effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SASE?. ### Response: statin associated side effects.


Instruction: What is ULN?

Output: upper limit of normal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ULN?. ### Response: upper limit of normal.


Instruction: What strategy demonstrated its greatest advantage in the highest-risk stratum of patients with no significant benefit on mortality over the noninvasive approach in moderate- and low-risk patients?

Output: invasive strategy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What strategy demonstrated its greatest advantage in the highest-risk stratum of patients with no significant benefit on mortality over the noninvasive approach in moderate- and low-risk patients?. ### Response: invasive strategy.


Instruction: What has been used with favorable results in initially stabilized patients with NSTE-ACS?

Output: An ischemia-guided strategy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been used with favorable results in initially stabilized patients with NSTE-ACS?. ### Response: An ischemia-guided strategy.


Instruction: What is a limitation of these studies?

Output: absence of adherence to optimal medical therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a limitation of these studies?. ### Response: absence of adherence to optimal medical therapy.


Instruction: What is the absence of adherence to optimal medical therapy in non-invasively treated patients dur ing long term management?

Output: One limitation of these studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the absence of adherence to optimal medical therapy in non-invasively treated patients dur ing long term management?. ### Response: One limitation of these studies.


Instruction: In FRISC-II, invasive management was what?

Output: delayed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In FRISC-II, invasive management was what?. ### Response: delayed.


Instruction: What was delayed in FRISC-II?

Output: invasive management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was delayed in FRISC-II?. ### Response: invasive management.


Instruction: What did patients with positive stress tests have to do in order to be randomized to noninvasive or invasive therapy?

Output: up to 2.9-mm exercise-induced ST depression

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did patients with positive stress tests have to do in order to be randomized to noninvasive or invasive therapy?. ### Response: up to 2.9-mm exercise-induced ST depression.