Instruction: Journal of the American College of Cardiology. 2010; 56(25):2090 -100 115.

Output: Can PRo -brain -natriuretic peptide guided therapy of  chronic heart failure IMprove heart fAilure morbidity and mortality?) study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Journal of the American College of Cardiology. 2010; 56(25):2090 -100 115.. ### Response: Can PRo -brain -natriuretic peptide guided therapy of  chronic heart failure IMprove heart fAilure morbidity and mortality?) study.


Instruction: What is the role of biomarkers in predicting outcome in patients with coronary artery disease and left ventricular dysfunction?

Output: Prognostic significance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of biomarkers in predicting outcome in patients with coronary artery disease and left ventricular dysfunction?. ### Response: Prognostic significance.


Instruction: What are the results of the Surgical Treatment for Ischemic Heart Failure trials?

Output: Prognostic significance of biomark ers in predicting outcome in patients with coronary artery disease and left ventricular dysfunction: results of the biomarker substudy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of the Surgical Treatment for Ischemic Heart Failure trials?. ### Response: Prognostic significance of biomark ers in predicting outcome in patients with coronary artery disease and left ventricular dysfunction: results of the biomarker substudy.


Instruction: Circulation: Heart Failure. 2013; 6(3):461 -72 116.

Output: Prognostic significance of biomark ers in predicting outcome in patients with coronary artery disease and left ventricular dysfunction: results of the biomarker substudy of the Surgical Treatment for Ischemic Heart Failure trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation: Heart Failure. 2013; 6(3):461 -72 116.. ### Response: Prognostic significance of biomark ers in predicting outcome in patients with coronary artery disease and left ventricular dysfunction: results of the biomarker substudy of the Surgical Treatment for Ischemic Heart Failure trials.


Instruction: What is the effect of natriuretic peptide -guided therapy on hospitalization or cardiovascular mortality in high-risk patients with heart failure and reduced ejection fraction?

Output: A randomized clinica l trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of natriuretic peptide -guided therapy on hospitalization or cardiovascular mortality in high-risk patients with heart failure and reduced ejection fraction?. ### Response: A randomized clinica l trial.


Instruction: What is the name of the study that examined heart failure patients' understanding of their medication?

Output: FAIR -HF trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined heart failure patients' understanding of their medication?. ### Response: FAIR -HF trial.


Instruction: What is Field K, Ziebland S, McPherson A, Lehman R.?

Output: tablets

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Field K, Ziebland S, McPherson A, Lehman R.?. ### Response: tablets.


Instruction: What is intravenous ferric carboxymaltose used for in chronic heart failure patients with and without anaemia?

Output: a subanalysis of the FAIR -HF trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is intravenous ferric carboxymaltose used for in chronic heart failure patients with and without anaemia?. ### Response: a subanalysis of the FAIR -HF trial.


Instruction: What is the name of the subanalysis of the FAIR -HF trial?

Output: Intravenous ferric carboxymaltose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the subanalysis of the FAIR -HF trial?. ### Response: Intravenous ferric carboxymaltose.


Instruction: What is the name of the randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure?

Output: SENI ORS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure?. ### Response: SENI ORS.


Instruction: What is SENI ORS?

Output: Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SENI ORS?. ### Response: Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure.


Instruction: When was the European Heart Journal published?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the European Heart Journal published?. ### Response: 2005.


Instruction: What is the focus of the study on battery replacement and end of life issues?

Output: Patients' experiences of the implantable cardioverter defibrillator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the focus of the study on battery replacement and end of life issues?. ### Response: Patients' experiences of the implantable cardioverter defibrillator.


Instruction: What is the title of the 2013 issue of the journal Pulmonary and Lung?

Output: Circulation: Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of the 2013 issue of the journal Pulmonary and Lung?. ### Response: Circulation: Heart Failure.


Instruction: Whose reflections on implantable cardioverter are discussed?

Output: Spouses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Whose reflections on implantable cardioverter are discussed?. ### Response: Spouses.


Instruction: What does Fluur C, Bolse K, Strömberg A, Thylén I. think about implanted cardioverters?

Output: Spouses' reflections

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Fluur C, Bolse K, Strömberg A, Thylén I. think about implanted cardioverters?. ### Response: Spouses' reflections.


Instruction: What is hydroxyurea used for in children?

Output: lowers transcranial Doppler flow velocities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hydroxyurea used for in children?. ### Response: lowers transcranial Doppler flow velocities.


Instruction: What is the Belgian experience?

Output: Hydroxyurea for sickle cell disease in children

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Belgian experience?. ### Response: Hydroxyurea for sickle cell disease in children.


Instruction: What does Hydroxyurea therapy lower in children with sickle cell disease?

Output: TCD velocities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Hydroxyurea therapy lower in children with sickle cell disease?. ### Response: TCD velocities.


Instruction: What is the name of the treatment that lowers TCD velocities in children?

Output: Hydroxyurea therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the treatment that lowers TCD velocities in children?. ### Response: Hydroxyurea therapy.


Instruction: What therapy lowers transcranial Doppler flow velocities in chil-dren with sickle cell anemia?

Output: Hydroxyurea

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What therapy lowers transcranial Doppler flow velocities in chil-dren with sickle cell anemia?. ### Response: Hydroxyurea.


Instruction: What does Hydroxyurea therapy lower?

Output: transcranial Doppler flow velocities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Hydroxyurea therapy lower?. ### Response: transcranial Doppler flow velocities.


Instruction: What did BABY HUG Investigators study?

Output: Influence of severity of anemia on clinical findings in infants with sickle cell anemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did BABY HUG Investigators study?. ### Response: Influence of severity of anemia on clinical findings in infants with sickle cell anemia.


Instruction: What was the impact of severity of anemia on clinical findings in infants with sickle cell anemia?

Output: analyses from the BABY HUG study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the impact of severity of anemia on clinical findings in infants with sickle cell anemia?. ### Response: analyses from the BABY HUG study.


Instruction: When was the Pediatr Blood Cancer published?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Pediatr Blood Cancer published?. ### Response: 2012.


Instruction: What is SFGM-TC?

Output: Long-term results of related myeloablative stem-cell transplantation to cure sickle cell disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SFGM-TC?. ### Response: Long-term results of related myeloablative stem-cell transplantation to cure sickle cell disease.


Instruction: What are the results of related myeloablative stem-cell transplantation to cure?

Output: sickle cell disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of related myeloablative stem-cell transplantation to cure?. ### Response: sickle cell disease.


Instruction: What does transplantation do to cure sickle cell disease?

Output: Pulmonary, gonadal, and central nervous system status

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does transplantation do to cure sickle cell disease?. ### Response: Pulmonary, gonadal, and central nervous system status.


Instruction: When did Blood. 2007:110:2749–2756.

Output: Long-term results of related myeloablative stem-cell transplantation to cure sickle cell disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Blood. 2007:110:2749–2756.. ### Response: Long-term results of related myeloablative stem-cell transplantation to cure sickle cell disease.


Instruction: What is the name of the study that examined sickle cells?

Output: Multicenter Study of Bone Marrow Transplantation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined sickle cells?. ### Response: Multicenter Study of Bone Marrow Transplantation.


Instruction: What is the name of the multicenter study of bone marrow transplantation for sickle cell disease?

Output: SFGM-TC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multicenter study of bone marrow transplantation for sickle cell disease?. ### Response: SFGM-TC.


Instruction: Pulmonary, gonadal, and central nervous system status after what type of transplantation?

Output: bone marrow

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Pulmonary, gonadal, and central nervous system status after what type of transplantation?. ### Response: bone marrow.


Instruction: What is the name of the study that investigated the relationship between migraine and ischaemic stroke in young women?

Output: Case-control study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the relationship between migraine and ischaemic stroke in young women?. ### Response: Case-control study.


Instruction: What is one of the findings from the study?

Output: Pulmonary, gonadal, and central nervous system status

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the findings from the study?. ### Response: Pulmonary, gonadal, and central nervous system status.


Instruction: When did the BMJ publish a 310-page report on migraine?

Output: 1995

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the BMJ publish a 310-page report on migraine?. ### Response: 1995.


Instruction: What is the name of the updated meta-analysis of migraine headache and ischemic stroke risk?

Output: Am J Med.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the updated meta-analysis of migraine headache and ischemic stroke risk?. ### Response: Am J Med..


Instruction: What are the names of the authors of the systematic review of migraine and cardiovascular disease?

Output: pton RB, Kurth T

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the authors of the systematic review of migraine and cardiovascular disease?. ### Response: pton RB, Kurth T.


Instruction: Where is the BMJ's 2009339:b3914?

Output: 595

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the BMJ's 2009339:b3914?. ### Response: 595.


Instruction: What is the name of the systematic review and meta-analysis of obser-vational studies in people with migraine?

Output: Risk of ischaemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta-analysis of obser-vational studies in people with migraine?. ### Response: Risk of ischaemic stroke.


Instruction: What does BMJ 2009 339:b3914. 595. Kurth T, Schurks M, Logroscino G, Buring JE. Migraine frequency and risk of what in women?

Output: cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does BMJ 2009 339:b3914. 595. Kurth T, Schurks M, Logroscino G, Buring JE. Migraine frequency and risk of what in women?. ### Response: cardiovascular disease.


Instruction: What is the frequency and risk of cardiovascular disease in women?

Output: Migraine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the frequency and risk of cardiovascular disease in women?. ### Response: Migraine.


Instruction: What was the name of the study that examined migraine in women in 2009?

Output: Neurology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the study that examined migraine in women in 2009?. ### Response: Neurology.


Instruction: Who was the author of this study?

Output: R, Wang WC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the author of this study?. ### Response: R, Wang WC.


Instruction: Who published the 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease?

Output: Arnett et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease?. ### Response: Arnett et al.


Instruction: What is the name of the guideline published in 2019?

Output: S4.5-33

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the guideline published in 2019?. ### Response: S4.5-33.


Instruction: Where is the Health and Medicine Division located?

Output: National Academies of Sciences, Engineering, and Medicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the Health and Medicine Division located?. ### Response: National Academies of Sciences, Engineering, and Medicine.


Instruction: What are the health consequences of e-cigarettes?

Output: Public Health Consequences of E-Cigarettes. Available at: http://nationalacademies.org/hmd/Reports/  2018/public-health-consequences-of-e-cigarettes.aspx; 2018. Accessed  January 5, 2019. S4.5-25. Ahmed AA, Patel K, Nyaku MA, et al. Risk of heart failure and death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the health consequences of e-cigarettes?. ### Response: Public Health Consequences of E-Cigarettes. Available at: http://nationalacademies.org/hmd/Reports/  2018/public-health-consequences-of-e-cigarettes.aspx; 2018. Accessed  January 5, 2019. S4.5-25. Ahmed AA, Patel K, Nyaku MA, et al. Risk of heart failure and death.


Instruction: What is the risk of heart failure and death after prolonged smoking cessation?

Output: role of amount and duration of prior smoking

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of heart failure and death after prolonged smoking cessation?. ### Response: role of amount and duration of prior smoking.


Instruction: What is NAADAC?

Output: Association for Addiction Professionals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NAADAC?. ### Response: Association for Addiction Professionals.


Instruction: What is the National Certificate in Tobacco Treatment Practice?

Output: NCTTP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the National Certificate in Tobacco Treatment Practice?. ### Response: NCTTP.


Instruction: What is the name of the National Certificate in Tobacco Treatment Practice?

Output: NCTTP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the National Certificate in Tobacco Treatment Practice?. ### Response: NCTTP.


Instruction: Where is the NCTTP available?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the NCTTP available?. ### Response: https://www.naadac.org/NCTTP.


Instruction: What is ATTUD?

Output: Association for the Treatment of Tobacco Use and Dependence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ATTUD?. ### Response: Association for the Treatment of Tobacco Use and Dependence.


Instruction: Training Programs. Accredited pro-grams. Available at: http://ctttp.org/accredited-programs?

Output: Council for Tobacco Treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Training Programs. Accredited pro-grams. Available at: http://ctttp.org/accredited-programs?. ### Response: Council for Tobacco Treatment.


Instruction: Accessed January 30, 2019.

Output: S4.5-30

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Accessed January 30, 2019.. ### Response: S4.5-30.


Instruction: Oono IP, Mackay DF, Pell JP. Meta-analysis of the association between what?

Output: secondhand smoke exposure and stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Oono IP, Mackay DF, Pell JP. Meta-analysis of the association between what?. ### Response: secondhand smoke exposure and stroke.


Instruction: What is the association between secondhand smoke exposure and stroke?

Output: Meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association between secondhand smoke exposure and stroke?. ### Response: Meta-analysis.


Instruction: When was the J Public Health (Oxf) published?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Public Health (Oxf) published?. ### Response: 2011.


Instruction: Where is the US Institute of Medicine Committee on Secondhand Smoke Exposure and Acute Coronary Events located?

Output: Washington, DC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the US Institute of Medicine Committee on Secondhand Smoke Exposure and Acute Coronary Events located?. ### Response: Washington, DC.


Instruction: Where is Making Sense of the Evidence published?

Output: National Academies Press

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Making Sense of the Evidence published?. ### Response: National Academies Press.


Instruction: What is the name of the book available at http://www.ncbi.nlm.nih.gov/books/NBK219565?

Output: Making Sense of the Evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the book available at http://www.ncbi.nlm.nih.gov/books/NBK219565?. ### Response: Making Sense of the Evidence.


Instruction: When did the US Department of Health and Human Services publish The health consequences of smoking-50 years of progress: A report of the Surgeon General?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the US Department of Health and Human Services publish The health consequences of smoking-50 years of progress: A report of the Surgeon General?. ### Response: 2014.


Instruction: Where is the Tobacco Control Legal Consortium located?

Output: Public Health Law Center

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the Tobacco Control Legal Consortium located?. ### Response: Public Health Law Center.


Instruction: What is HUD's rule to restrict smoking in public housing an overview?

Output: S4.5-33

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is HUD's rule to restrict smoking in public housing an overview?. ### Response: S4.5-33.


Instruction: When was the HUD-Final-Rule-Smoke-Free-Public-Housing-2016.pdf available?

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the HUD-Final-Rule-Smoke-Free-Public-Housing-2016.pdf available?. ### Response: 2017.


Instruction: How is aspirin used?

Output: primary prevention in adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is aspirin used?. ### Response: primary prevention in adults.


Instruction: Aspirin for the pri-mary prevention of cardiovascular events: a systematic evidence review for the US Preventive Services Task Force.

Output: 804–13

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Aspirin for the pri-mary prevention of cardiovascular events: a systematic evidence review for the US Preventive Services Task Force.. ### Response: 804–13.


Instruction: What did Whitlock EP, Burda BU, Williams SB, et al. do with aspirin use for primary prevention?

Output: Bleeding risks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Whitlock EP, Burda BU, Williams SB, et al. do with aspirin use for primary prevention?. ### Response: Bleeding risks.


Instruction: What is the purpose of the US Preventive Services Task Force?

Output: systematic evidence review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of the US Preventive Services Task Force?. ### Response: systematic evidence review.


Instruction: What are two factors related to physician clinical decision-making for African-American and Hispanic patients?

Output: Breathett

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are two factors related to physician clinical decision-making for African-American and Hispanic patients?. ### Response: Breathett.


Instruction: What is a qualitativemeta-synthesis?

Output: Factorsrelated to physician clinical decision-making forAfrican-American and Hispanic patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a qualitativemeta-synthesis?. ### Response: Factorsrelated to physician clinical decision-making forAfrican-American and Hispanic patients.


Instruction: Krishnaswami A, Steinman MA, Goyal P, et al.Deprescribing in older adults with what?

Output: cardiovascular dis-ease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Krishnaswami A, Steinman MA, Goyal P, et al.Deprescribing in older adults with what?. ### Response: cardiovascular dis-ease.


Instruction: What is inter-twined with heart failure: mechanisms, prevalence, prognosis, assessment, and assessment?

Output: Frailty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is inter-twined with heart failure: mechanisms, prevalence, prognosis, assessment, and assessment?. ### Response: Frailty.


Instruction: What is the impact of frailtyon mortality and hospitalization in chronic heart fail-ure?

Output: a systematic review and meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact of frailtyon mortality and hospitalization in chronic heart fail-ure?. ### Response: a systematic review and meta-analysis.


Instruction: What is inter-twined with heart failure: mechanisms, prevalence, prognosis, assessment and management?

Output: Frailty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is inter-twined with heart failure: mechanisms, prevalence, prognosis, assessment and management?. ### Response: Frailty.


Instruction: What is the J Am CollCardiol HF. 2019;7:1001 -11.141?

Output: Frailty is inter-twined with heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the J Am CollCardiol HF. 2019;7:1001 -11.141?. ### Response: Frailty is inter-twined with heart failure.


Instruction: Who is responsible for forecasting the impact of heart failure in the US?

Output: American Heart Associa-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is responsible for forecasting the impact of heart failure in the US?. ### Response: American Heart Associa-tion.


Instruction: What year did the American Heart Association publish a report on heart disease and stroke?

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did the American Heart Association publish a report on heart disease and stroke?. ### Response: 2016.


Instruction: What is the name of the organization that published the 2016 report?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that published the 2016 report?. ### Response: American Heart Association.


Instruction: How many patients were hospitalized with heart failure?

Output: 72.147

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were hospitalized with heart failure?. ### Response: 72.147.


Instruction: What is a factor associated with diabetesmellitus among patients hospitalized with heart failure?

Output: Temporal trends

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a factor associated with diabetesmellitus among patients hospitalized with heart failure?. ### Response: Temporal trends.


Instruction: What is the name of the organization that found factors associated with diabetic heart failure among hospitalized heart failure patients?

Output: Get With The Guidelines-Heart Failureregistry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that found factors associated with diabetic heart failure among hospitalized heart failure patients?. ### Response: Get With The Guidelines-Heart Failureregistry.


Instruction: When was the Am Heart J.182:9–20.144 published?

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Am Heart J.182:9–20.144 published?. ### Response: 2016.


Instruction: What is the difference between sacubitril and ena-lapril in patients with heart failure and reduced ejectionfraction?

Output: Cost-effectiveness analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between sacubitril and ena-lapril in patients with heart failure and reduced ejectionfraction?. ### Response: Cost-effectiveness analysis.


Instruction: What are the outcomes of canagli flozinand in type 2 diabetes and nephropa-thy?

Output: renal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the outcomes of canagli flozinand in type 2 diabetes and nephropa-thy?. ### Response: renal.


Instruction: What is ivabradine used for in the United States?

Output: heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ivabradine used for in the United States?. ### Response: heart failure.


Instruction: What is the effect of sacubitril-valsartan on heart failure?

Output: effective-ness and value

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of sacubitril-valsartan on heart failure?. ### Response: effective-ness and value.


Instruction: What is the cost-effectiveness of ivabradine for heart failure in the United States?

Output: Cost-effectiveness of ivabradine for heart failure in theUnited States. J Am Heart Assoc. 2016;5:e003221 .149

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cost-effectiveness of ivabradine for heart failure in the United States?. ### Response: Cost-effectiveness of ivabradine for heart failure in theUnited States. J Am Heart Assoc. 2016;5:e003221 .149.


Instruction: What did Clarkson EB, Linley A, FrankJS, et al. Theimplementation of a patient assistance program in afree clinic setting: a case report?

Output: sacubitril/valsartan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Clarkson EB, Linley A, FrankJS, et al. Theimplementation of a patient assistance program in afree clinic setting: a case report?. ### Response: sacubitril/valsartan.


Instruction: What is the mor-tality risk of deferring optimal medical therapy in heart failure?

Output: a systematic comparison against norms forsurgical consent and patient information lea ﬂets

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the mor-tality risk of deferring optimal medical therapy in heart failure?. ### Response: a systematic comparison against norms forsurgical consent and patient information lea ﬂets.


Instruction: What is a systematic comparison against norms for surgical therapy?

Output: Cost-effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a systematic comparison against norms for surgical therapy?. ### Response: Cost-effectiveness.


Instruction: What is a systematic comparison against norms for surgical consent and patient information lea flets?

Output: The mor-tality risk of deferring optimal medical therapy in heartfailure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a systematic comparison against norms for surgical consent and patient information lea flets?. ### Response: The mor-tality risk of deferring optimal medical therapy in heartfailure.


Instruction: What did Dunlay SM, Givertz MM, Aguilar D, et al. study type 2 diabetes mellitus and heart failure: a scienti fic state-of-the-art study?

Output: The mor-tality risk of deferring optimal medical therapy in heartfailure: a systematic comparison against norms forsurgical consent and patient information lea ﬂets.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Dunlay SM, Givertz MM, Aguilar D, et al. study type 2 diabetes mellitus and heart failure: a scienti fic state-of-the-art study?. ### Response: The mor-tality risk of deferring optimal medical therapy in heartfailure: a systematic comparison against norms forsurgical consent and patient information lea ﬂets..


Instruction: How many different prophylactic dose regimens of low molecular weight heparin in bariatric surgery are there?

Output: two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many different prophylactic dose regimens of low molecular weight heparin in bariatric surgery are there?. ### Response: two.


Instruction: What year was Obes Surg. 2002?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was Obes Surg. 2002?. ### Response: 2002.


Instruction: How many ( 1 ): 19-24?

Output: 12

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many ( 1 ): 19-24?. ### Response: 12.


Instruction: What is the name of the study that investigated the pharmacodynamics of low molecular weight?

Output: BAFLUX study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the pharmacodynamics of low molecular weight?. ### Response: BAFLUX study.


Instruction: How many doses of parnaparin were compared in the BAFLUX study?

Output: two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many doses of parnaparin were compared in the BAFLUX study?. ### Response: two.


Instruction: How many heparins were used in the study?

Output: two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many heparins were used in the study?. ### Response: two.


Instruction: What were the results of the studies?

Output: Pharmacokinetic studies of standard unfractionated heparin, and low molec-ular weight heparins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the results of the studies?. ### Response: Pharmacokinetic studies of standard unfractionated heparin, and low molec-ular weight heparins.


Instruction: How many low-molecular-weight drugs were used?

Output: two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many low-molecular-weight drugs were used?. ### Response: two.


Instruction: How many low-molecular-weight heparin dosing regimens were compared for patients undergoing laparoscopic bariatric surgery?

Output: two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many low-molecular-weight heparin dosing regimens were compared for patients undergoing laparoscopic bariatric surgery?. ### Response: two.


Instruction: What year did Surg Endosc publish its 22 ( 11): 2392 - 2395?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Surg Endosc publish its 22 ( 11): 2392 - 2395?. ### Response: 2008.


Instruction: What is the pharmacokinetics of subcutaneous enoxaparin in end-stage renal disease?

Output: thrombocytopenia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the pharmacokinetics of subcutaneous enoxaparin in end-stage renal disease?. ### Response: thrombocytopenia.


Instruction: What is end-stage renal disease?

Output: The pharmacokinetics of subcutaneous enoxaparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is end-stage renal disease?. ### Response: The pharmacokinetics of subcutaneous enoxaparin.


Instruction: What is the name of the drug that was used to treat end stage renal disease in 2001?

Output: enoxaparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug that was used to treat end stage renal disease in 2001?. ### Response: enoxaparin.


Instruction: What is heparin?

Output: low-molecular-weight

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is heparin?. ### Response: low-molecular-weight.


Instruction: What is the name of the drug used in various stages of chronic renal failure?

Output: Fraxiparine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used in various stages of chronic renal failure?. ### Response: Fraxiparine.


Instruction: How many cases were there in 1991?

Output: 543 - 545

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many cases were there in 1991?. ### Response: 543 - 545.


Instruction: What is the correlation of antifactor Xa concentrations with?

Output: 122

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the correlation of antifactor Xa concentrations with?. ### Response: 122.


Instruction: How many. 155?

Output: 155

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many. 155?. ### Response: 155.


Instruction: What does Chow SL do?

Output: pharmacokinetics of subcutaneous enoxaparin in end-stage renal disease .   Pharmacotherapy  .  2001 ; 21 ( 2 ): 169 - 174 .      154 .  Goudable   C ,  Saivin   S ,  Houin   G ,  et al .  Pharmacokinetics of a low molecular weight heparin (Fraxiparine) in various stages of chronic renal failure .   Nephron  .  1991 ; 59 ( 4 ): 543 - 545 .      155 .  Chow

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Chow SL do?. ### Response: pharmacokinetics of subcutaneous enoxaparin in end-stage renal disease .   Pharmacotherapy  .  2001 ; 21 ( 2 ): 169 - 174 .      154 .  Goudable   C ,  Saivin   S ,  Houin   G ,  et al .  Pharmacokinetics of a low molecular weight heparin (Fraxiparine) in various stages of chronic renal failure .   Nephron  .  1991 ; 59 ( 4 ): 543 - 545 .      155 .  Chow.


Instruction: What is the correlation of antifactor Xa concentrations with 122?

Output: Correlation of antifactor Xa concentrations with     122 .  Anderson

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the correlation of antifactor Xa concentrations with 122?. ### Response: Correlation of antifactor Xa concentrations with     122 .  Anderson.


Instruction: Anderson DR, O'Brien BJ, Levine MN, Roberts R, Wells PS, and Hirsh J.

Output: Roberts   R ,  Wells   PS ,  Hirsh   J .  Efﬁ  cacy and cost of low-molecular-weight heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Anderson DR, O'Brien BJ, Levine MN, Roberts R, Wells PS, and Hirsh J.. ### Response: Roberts   R ,  Wells   PS ,  Hirsh   J .  Efﬁ  cacy and cost of low-molecular-weight heparin.


Instruction: What is low-molecular-weight heparin compared with?

Output: standard heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is low-molecular-weight heparin compared with?. ### Response: standard heparin.


Instruction: What is the cost of low-molecular weight hepatin?

Output: 107 - 112

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cost of low-molecular weight hepatin?. ### Response: 107 - 112.


Instruction: When was the Ann Intern Med published?

Output: 1993

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Ann Intern Med published?. ### Response: 1993.


Instruction: What is the name of the randomized trial comparing 5-mg and 10-mg warfarin?

Output: Arch Intern Med

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized trial comparing 5-mg and 10-mg warfarin?. ### Response: Arch Intern Med.


Instruction: When was the 119 ( 11 ): 1105-1112?

Output: 1993

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the 119 ( 11 ): 1105-1112?. ### Response: 1993.


Instruction: A randomized trial comparing 5-mg and 10-mg warfarin loading doses was conducted in what year?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A randomized trial comparing 5-mg and 10-mg warfarin loading doses was conducted in what year?. ### Response: 1999.


Instruction: What is heparin-induced thrombocytopenia in patients treated with low-molecular-weight or unfractionated?

Output: unfractionated

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is heparin-induced thrombocytopenia in patients treated with low-molecular-weight or unfractionated?. ### Response: unfractionated.


Instruction: What is the N Engl J Med. 1995 ; 332 ( 20): 1330?

Output: Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin .   N Engl J Med  .   1995 ; 332 ( 20 ): 1330 - 1335

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the N Engl J Med. 1995 ; 332 ( 20): 1330?. ### Response: Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin .   N Engl J Med  .   1995 ; 332 ( 20 ): 1330 - 1335.


Instruction: How many ( 20 ): 1330 - 1335?

Output: 332

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many ( 20 ): 1330 - 1335?. ### Response: 332.


Instruction: What was the length of time between 1330 and 1335 in 1995?

Output: 332 ( 20 ):

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the length of time between 1330 and 1335 in 1995?. ### Response: 332 ( 20 ):.


Instruction: What is heparin a synthetic pen-tasaccharide with high affi nity for antithrombin III and eliciting high anti-factor Xa activity?

Output: Structure-activity relationship

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is heparin a synthetic pen-tasaccharide with high affi nity for antithrombin III and eliciting high anti-factor Xa activity?. ### Response: Structure-activity relationship.


Instruction: What year was Biochem Biophys Res Commun published?

Output: 1983

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was Biochem Biophys Res Commun published?. ### Response: 1983.


Instruction: How many ( 2 ): 492-499?

Output: 116

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many ( 2 ): 492-499?. ### Response: 116.


Instruction: Handeland GF, Abildgaard U, Holm HA, and Arnesen KE were published in 1983?

Output: 1983

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Handeland GF, Abildgaard U, Holm HA, and Arnesen KE were published in 1983?. ### Response: 1983.


Instruction: What is a comparison of unfractionated and low molecular weight heparin for deep venous throm-bosis?

Output: Dose adjusted heparin treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a comparison of unfractionated and low molecular weight heparin for deep venous throm-bosis?. ### Response: Dose adjusted heparin treatment.


Instruction: When was the Eur J Clin Pharmacol published?

Output: 1990

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Eur J Clin Pharmacol published?. ### Response: 1990.


Instruction: How many pharmacokinetic studies of standard unfractionated heparin and low molec-ular weight heparains have been conducted?

Output: 39

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many pharmacokinetic studies of standard unfractionated heparin and low molec-ular weight heparains have been conducted?. ### Response: 39.


Instruction: What is the name of the drug that has been shown to have a high molecular weight?

Output: heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug that has been shown to have a high molecular weight?. ### Response: heparin.


Instruction: What is standard unfractionated heparin in the rabbit?

Output: low molec-ular weight

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is standard unfractionated heparin in the rabbit?. ### Response: low molec-ular weight.


Instruction: What is low molec-ular weight?

Output: heparin or unfractionated heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is low molec-ular weight?. ### Response: heparin or unfractionated heparin.


Instruction: When was Semin Thromb Hemost. 14 (1): 18-27. 128?

Output: 1988

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Semin Thromb Hemost. 14 (1): 18-27. 128?. ### Response: 1988.


Instruction: What is the pharmacokinetics of heparin and low?

Output: standard unfractionated heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the pharmacokinetics of heparin and low?. ### Response: standard unfractionated heparin.


Instruction: What has recently been evaluated as a nondrug alternative for stroke prevention in patients with AF?

Output: Percutaneous closure of the left atrial appendage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has recently been evaluated as a nondrug alternative for stroke prevention in patients with AF?. ### Response: Percutaneous closure of the left atrial appendage.


Instruction: What is the PROTECT-AF (WATCHMAN Left) similar to the 33% relative reduction in stroke achieved?

Output: dabigatran 150 mg bid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the PROTECT-AF (WATCHMAN Left) similar to the 33% relative reduction in stroke achieved?. ### Response: dabigatran 150 mg bid.


Instruction: How much is dabigatran 150 mg bid compared with VKA therapy?

Output: 33%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much is dabigatran 150 mg bid compared with VKA therapy?. ### Response: 33%.


Instruction: What would likely not exist for motivated patients who are able to participate in home monitoring?

Output: dabigatran

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would likely not exist for motivated patients who are able to participate in home monitoring?. ### Response: dabigatran.


Instruction: What will reduce the burden of INR testing and VKA dose adjustment?

Output: home monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will reduce the burden of INR testing and VKA dose adjustment?. ### Response: home monitoring.


Instruction: The burdens of VKA therapy related to dietary restrictions and drug interactions will still exist, and there will be a cost for what?

Output: the home monitoring device and test strips

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The burdens of VKA therapy related to dietary restrictions and drug interactions will still exist, and there will be a cost for what?. ### Response: the home monitoring device and test strips.


Instruction: What may some patients choose instead of home monitoring of VKA therapy?

Output: dabigatran

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may some patients choose instead of home monitoring of VKA therapy?. ### Response: dabigatran.


Instruction: Before prescribing dabigatran, clinicians need to judge whether a patient is similar enough to those enrolled in RE-LY?

Output: clinical trial results are still likely to apply

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Before prescribing dabigatran, clinicians need to judge whether a patient is similar enough to those enrolled in RE-LY?. ### Response: clinical trial results are still likely to apply.


Instruction: What type of impairment was excluded from the RE-LY study?

Output: severe renal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of impairment was excluded from the RE-LY study?. ### Response: severe renal.


Instruction: What is the estimated creatinine clearance of patients with renal impairment?

Output: 30 mL/min or less

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the estimated creatinine clearance of patients with renal impairment?. ### Response: 30 mL/min or less.


Instruction: The cost-effectiveness of the new anticoagulants compared with VKA therapy is what?

Output: consider-ation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The cost-effectiveness of the new anticoagulants compared with VKA therapy is what?. ### Response: consider-ation.


Instruction: What is another factor to consider when considering new anticoagulants compared with VKA therapy?

Output: cost-effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another factor to consider when considering new anticoagulants compared with VKA therapy?. ### Response: cost-effectiveness.


Instruction: How much more would dabigatran cost per quality-adjusted life year gained compared to warfarin for patients with AF?

Output: $45,372

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much more would dabigatran cost per quality-adjusted life year gained compared to warfarin for patients with AF?. ### Response: $45,372.


Instruction: What was the life year gained compared with warfarin for patients with AF aged 65 years with risk factors for stroke?

Output: $45,372

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the life year gained compared with warfarin for patients with AF aged 65 years with risk factors for stroke?. ### Response: $45,372.


Instruction: The cost-effectiveness estimates in this model were sensitive to what?

Output: pricing of dabigatran

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The cost-effectiveness estimates in this model were sensitive to what?. ### Response: pricing of dabigatran.


Instruction: What is the target INR range for patients with AF?

Output: 2.0-3.0

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the target INR range for patients with AF?. ### Response: 2.0-3.0.


Instruction: What are the recommendations in favor of oral anticoagulation?

Output: 2.1.9, 2.1.10, and excluding 2.2, 3.1, 3.2, 3.3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the recommendations in favor of oral anticoagulation?. ### Response: 2.1.9, 2.1.10, and excluding 2.2, 3.1, 3.2, 3.3.


Instruction: What is the target INR range?

Output: 2.0-3.0

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the target INR range?. ### Response: 2.0-3.0.


Instruction: What is excreted primarily by the kidney?

Output: igatran

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is excreted primarily by the kidney?. ### Response: igatran.


Instruction: When is Dabigatran contraindi-cated in patients with severe renal impairment?

Output: twice daily

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is Dabigatran contraindi-cated in patients with severe renal impairment?. ### Response: twice daily.


Instruction: What is the estimated creatinine clearance of /H11349 30 mL/min?

Output: igatran

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the estimated creatinine clearance of /H11349 30 mL/min?. ### Response: igatran.


Instruction: Clinicians should be aware that there is no antidote for what drug?

Output: dabigatran

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Clinicians should be aware that there is no antidote for what drug?. ### Response: dabigatran.


Instruction: What should treatment decisions be individualized based on?

Output: patient values and preferences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should treatment decisions be individualized based on?. ### Response: patient values and preferences.


Instruction: What is based on patient values and preferences in this case?

Output: treatment decisions should be individualized

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is based on patient values and preferences in this case?. ### Response: treatment decisions should be individualized.


Instruction: What is an assessment of bleeding risk and a consid eration of additional risk factors for stroke?

Output: Bleeding Risk Assessment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an assessment of bleeding risk and a consid eration of additional risk factors for stroke?. ### Response: Bleeding Risk Assessment.


Instruction: What year did Kimberly Henricks become president of the American College of Chest Physicians?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Kimberly Henricks become president of the American College of Chest Physicians?. ### Response: 2012.


Instruction: What is the name of the author of the book chestjournal.chestpubs.org?

Output: Kimberly Henricks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the author of the book chestjournal.chestpubs.org?. ### Response: Kimberly Henricks.


Instruction: What is the effect of ampicillin plus ceftriaxone on experimental endocarditis?

Output: Efficacy of ampicillin plus ceftriaxone in treatment of experimental endocarditis due to Enterococcus faecalis strains highly resistant to aminoglycosides

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of ampicillin plus ceftriaxone on experimental endocarditis?. ### Response: Efficacy of ampicillin plus ceftriaxone in treatment of experimental endocarditis due to Enterococcus faecalis strains highly resistant to aminoglycosides.


Instruction: What are Enterococcus faecalis strains highly resistant to?

Output: aminoglycosides

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are Enterococcus faecalis strains highly resistant to?. ### Response: aminoglycosides.


Instruction: When did Antimicrob Agents Chemother issue 43:639-646?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Antimicrob Agents Chemother issue 43:639-646?. ### Response: 1999.


Instruction: How did Arias CA, Contreras GA, Murray BE manage multidrug-resistant enterococcal infections?

Output: combination tigecycline and high-dose daptomycin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Arias CA, Contreras GA, Murray BE manage multidrug-resistant enterococcal infections?. ### Response: combination tigecycline and high-dose daptomycin.


Instruction: What year was the outbreak of linezolid-resistant enterococci?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the outbreak of linezolid-resistant enterococci?. ### Response: 2007.


Instruction: What year did Emerg Infect Dis. 2007:13:1024-1030?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Emerg Infect Dis. 2007:13:1024-1030?. ### Response: 2007.


Instruction: What drug is used for the treatment of multidrug-resistant, gram-positive infections?

Output: Linezolid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug is used for the treatment of multidrug-resistant, gram-positive infections?. ### Response: Linezolid.


Instruction: What is the name of the program that provides Linezolid?

Output: compassionate-use program

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the program that provides Linezolid?. ### Response: compassionate-use program.


Instruction: When did Clin Infect Dis 2003 issue 36:159–168?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Clin Infect Dis 2003 issue 36:159–168?. ### Response: 2003.


Instruction: What drug is as effective as daptomycin?

Output: linezolid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug is as effective as daptomycin?. ### Response: linezolid.


Instruction: What is the effect of linezolid on bacteraemia?

Output: outbreak of linezolid-resistant enterococci

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of linezolid on bacteraemia?. ### Response: outbreak of linezolid-resistant enterococci.


Instruction: When did the J Antimicrob Chemother issue 64:175-181. doi: 10.1093/jac/dkp154?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the J Antimicrob Chemother issue 64:175-181. doi: 10.1093/jac/dkp154?. ### Response: 2009.


Instruction: How was the treatment of vancomycin-resistant enterococcus endo-carditis?

Output: Successful treatment of vancomycin-resistant enterococcus endo-carditis with oral linezolid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the treatment of vancomycin-resistant enterococcus endo-carditis?. ### Response: Successful treatment of vancomycin-resistant enterococcus endo-carditis with oral linezolid.


Instruction: What is the name of the drug used to treat prosthetic valve infective endocarditis due to multi-resistant Gram-positive bacteria?

Output: linezolid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used to treat prosthetic valve infective endocarditis due to multi-resistant Gram-positive bacteria?. ### Response: linezolid.


Instruction: What year did J Infect. 2006:52:300-304?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did J Infect. 2006:52:300-304?. ### Response: 2005.


Instruction: What type of endocarditis is Vancomycin-resistant Enterococcus faecalis?

Output: Infective

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of endocarditis is Vancomycin-resistant Enterococcus faecalis?. ### Response: Infective.


Instruction: What is the name of the journal that describes the characterization of virulence factors?

Output: J Clin Microbiol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that describes the characterization of virulence factors?. ### Response: J Clin Microbiol.


Instruction: How is Daptomycin resistance determined in Enterococcius Faecalis?

Output: linezolid fail-ure and strain characterization of virulence factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is Daptomycin resistance determined in Enterococcius Faecalis?. ### Response: linezolid fail-ure and strain characterization of virulence factors.


Instruction: When was the J Antimicrob Chemother published?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Antimicrob Chemother published?. ### Response: 2008.


Instruction: What is a prosthetic valve endocarditis?

Output: infective endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a prosthetic valve endocarditis?. ### Response: infective endocarditis.


Instruction: What is the name of the journal that studies the use of daptomycin in the treatment of patients with infec-tive endocrine disease?

Output: Ann Pharmacother.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies the use of daptomycin in the treatment of patients with infec-tive endocrine disease?. ### Response: Ann Pharmacother..


Instruction: When did Am J Med issue 120(suppl 1):S28–S33?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Am J Med issue 120(suppl 1):S28–S33?. ### Response: 2007.


Instruction: How many patients were treated with daptomycin for gram-positive bacteremia and infective endocarditis?

Output: 31

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with daptomycin for gram-positive bacteremia and infective endocarditis?. ### Response: 31.


Instruction: What is the name of the retrospective case series of 31 patients?

Output: ocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the retrospective case series of 31 patients?. ### Response: ocarditis.


Instruction: When did Pharmacotherapy. 2006:26:347–352. doi: 10.1592/phco.26.3.347.

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Pharmacotherapy. 2006:26:347–352. doi: 10.1592/phco.26.3.347.. ### Response: 2006.


Instruction: What was a case report of?

Output: Infective endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a case report of?. ### Response: Infective endocarditis.


Instruction: What year did Scand J Infect Dis publish?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Scand J Infect Dis publish?. ### Response: 2007.


Instruction: What is the name of the 2007 study that investigated multidrug-resistant Enterococcus faecium endo-carditis treated with combination tigecycline and high-dose daptomycin?

Output: J Clin Microbiol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2007 study that investigated multidrug-resistant Enterococcus faecium endo-carditis treated with combination tigecycline and high-dose daptomycin?. ### Response: J Clin Microbiol.


Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al.


Instruction: What is the name of the guideline for management of valve heart disease?

Output: ACC/AHA Guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the guideline for management of valve heart disease?. ### Response: ACC/AHA Guideline.


Instruction: When did Otto and colleagues publish their guideline?

Output: February 2, 2021

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Otto and colleagues publish their guideline?. ### Response: February 2, 2021.


Instruction: How much warfarin do women with mechanical prostheses need to take?

Output: >5 mg/d

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much warfarin do women with mechanical prostheses need to take?. ### Response: >5 mg/d.


Instruction: What is the target anti-Xa level for 4 to 6 hours after dose?

Output: 0.8 to 1.2 U/mL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the target anti-Xa level for 4 to 6 hours after dose?. ### Response: 0.8 to 1.2 U/mL.


Instruction: How long after dose should LMWH be adjusted?

Output: 4 to 6 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after dose should LMWH be adjusted?. ### Response: 4 to 6 hours.


Instruction: At least how many times per day for all 3 trimesters may be considered?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: At least how many times per day for all 3 trimesters may be considered?. ### Response: 2.


Instruction: For pregnant women with mechanical prostheses who require a dose of warfarin 5 mg/d to maintain a therapeutic INR, dose-adjusted LMWH at least twice per day?

Output: all 3 trimesters

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For pregnant women with mechanical prostheses who require a dose of warfarin 5 mg/d to maintain a therapeutic INR, dose-adjusted LMWH at least twice per day?. ### Response: all 3 trimesters.


Instruction: What may be considered for pregnant women with mechanical prostheses?

Output: aspirin 75 to 100 mg daily

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered for pregnant women with mechanical prostheses?. ### Response: aspirin 75 to 100 mg daily.


Instruction: How many times per day is therapeutic INR?

Output: 75 to 100 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many times per day is therapeutic INR?. ### Response: 75 to 100 mg.


Instruction: What is dose-adjusted LMWH at least twice per day during the first trimester?

Output: For pregnant women with mechanical prostheses who require a dose of warfarin ≤5 mg/d to maintain a therapeutic INR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is dose-adjusted LMWH at least twice per day during the first trimester?. ### Response: For pregnant women with mechanical prostheses who require a dose of warfarin ≤5 mg/d to maintain a therapeutic INR.


Instruction: Warfarin for the second and third trimesters?

Output: dose-adjusted LMWH at least 2 times per day

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Warfarin for the second and third trimesters?. ### Response: dose-adjusted LMWH at least 2 times per day.


Instruction: What may be considered in addition to anticoagulation if needed for other indications?

Output: aspirin 75 to 100 mg daily

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered in addition to anticoagulation if needed for other indications?. ### Response: aspirin 75 to 100 mg daily.


Instruction: For pregnant women with mechanical prostheses, LMWH should not be administered unless anti-Xa levels are monitored 4 to 6 hours after administration and dose is adjusted according to levels?

Output: 0.8 to 1.2 U/mL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For pregnant women with mechanical prostheses, LMWH should not be administered unless anti-Xa levels are monitored 4 to 6 hours after administration and dose is adjusted according to levels?. ### Response: 0.8 to 1.2 U/mL.


Instruction: What is the name of the direct thrombin inhibitor?

Output: dabigatran

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the direct thrombin inhibitor?. ### Response: dabigatran.


Instruction: What should not be administered to patients with mechanical valve prostheses?

Output: anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not be administered to patients with mechanical valve prostheses?. ### Response: anticoagulation.


Instruction: How is the use of anti-Xa direct oral anticoagulants evaluated?

Output: not been assessed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the use of anti-Xa direct oral anticoagulants evaluated?. ### Response: not been assessed.


Instruction: What is not recommended in pregnancy?

Output: The use of anti-Xa direct oral anticoagulants with mechanical heart valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended in pregnancy?. ### Response: The use of anti-Xa direct oral anticoagulants with mechanical heart valves.


Instruction: What is at increased risk for pregnant women with mechanical heart valves?

Output: serious maternal complications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is at increased risk for pregnant women with mechanical heart valves?. ### Response: serious maternal complications.


Instruction: How is the risk of poor fetal outcomes?

Output: high

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the risk of poor fetal outcomes?. ### Response: high.


Instruction: What percentage of women with mechanical heart valves have a serious maternal or fetal complication during pregnancy?

Output: More than one-third

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of women with mechanical heart valves have a serious maternal or fetal complication during pregnancy?. ### Response: More than one-third.


Instruction: What is the most effective anticoagulant at preventing thrombotic complications?

Output: Warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most effective anticoagulant at preventing thrombotic complications?. ### Response: Warfarin.


Instruction: All women with mechanical heart valves require uninterrupted therapeutic anticoagulation throughout pregnancy?

Output: The choice of anticoagulation strategy is challenging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: All women with mechanical heart valves require uninterrupted therapeutic anticoagulation throughout pregnancy?. ### Response: The choice of anticoagulation strategy is challenging.


Instruction: What crosses the placenta and can cause miscarriage, spontaneous abortion, war-farin embryopathy, or fetal intracranial hemorrhage?

Output: warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What crosses the placenta and can cause miscarriage, spontaneous abortion, war-farin embryopathy, or fetal intracranial hemorrhage?. ### Response: warfarin.


Instruction: Women with me-chanical heart valves on LMWH are at increased risk of what?

Output: thrombotic events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Women with me-chanical heart valves on LMWH are at increased risk of what?. ### Response: thrombotic events.


Instruction: What is an increased risk of when LMWH is im-properly dosed, monitored, or administered?

Output: thrombotic events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an increased risk of when LMWH is im-properly dosed, monitored, or administered?. ### Response: thrombotic events.


Instruction: What type of CKD has been confirmed in patients with or without diabetes?

Output: albuminuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of CKD has been confirmed in patients with or without diabetes?. ### Response: albuminuria.


Instruction: What group believes patients and providers would want to avoid hyperkalemia and AKI?

Output: The Work Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What group believes patients and providers would want to avoid hyperkalemia and AKI?. ### Response: The Work Group.


Instruction: What does dual RASi therapy decrease proteinuria?

Output: very high levels of albuminuri

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does dual RASi therapy decrease proteinuria?. ### Response: very high levels of albuminuri.


Instruction: What is a consideration for implementation?

Output: Resource use and costs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a consideration for implementation?. ### Response: Resource use and costs.


Instruction: What type of therapy is used to treat very high levels of albuminuriain selected patients?

Output: dual therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is used to treat very high levels of albuminuriain selected patients?. ### Response: dual therapy.


Instruction: There is no RCT data on what?

Output: safety orkidney

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is no RCT data on what?. ### Response: safety orkidney.


Instruction: What are dedicated clinics superior to?

Output: historical controls

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are dedicated clinics superior to?. ### Response: historical controls.


Instruction: What is insuf ficient todifferentiate between men and women for this recommenda-tion?

Output: 294There is insuf ﬁcient information

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is insuf ficient todifferentiate between men and women for this recommenda-tion?. ### Response: 294There is insuf ﬁcient information.


Instruction: What should be discouraged for patients with CKD?

Output: dual therapys

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be discouraged for patients with CKD?. ### Response: dual therapys.


Instruction: What is the belief that dual therapies of RASi are beneficial compared to monotherapies stemmed only from?

Output: theimprovement in albuminuria with dual therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the belief that dual therapies of RASi are beneficial compared to monotherapies stemmed only from?. ### Response: theimprovement in albuminuria with dual therapy.


Instruction: What did the addition of an MRA to an ACEi or ARB for renoprotection inpatients with diabetes and kidney disease result in?

Output: a reduc-tion of albuminuria but a higher risk of hyperkalemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the addition of an MRA to an ACEi or ARB for renoprotection inpatients with diabetes and kidney disease result in?. ### Response: a reduc-tion of albuminuria but a higher risk of hyperkalemia.


Instruction: What was reduced by adding spironolactone, epler-enone, or finerenone?

Output: albuminuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was reduced by adding spironolactone, epler-enone, or finerenone?. ### Response: albuminuria.


Instruction: No adequately powered study has been completed with spi-ronolactone or eplerenone?

Output: Beyondalbuminuria, no adequately powered study examining GFRand kidney failure outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No adequately powered study has been completed with spi-ronolactone or eplerenone?. ### Response: Beyondalbuminuria, no adequately powered study examining GFRand kidney failure outcomes.


Instruction: The FIDELIOtrial showed kidney and cardiovascular protection by finer-enone despite its modest effect on what?

Output: SBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The FIDELIOtrial showed kidney and cardiovascular protection by finer-enone despite its modest effect on what?. ### Response: SBP.


Instruction: What is the FIGARO trial testing on the background of an ACEi or ARB in patients with diabetes and kidney disease?

Output: erenone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the FIGARO trial testing on the background of an ACEi or ARB in patients with diabetes and kidney disease?. ### Response: erenone.


Instruction: What are the benefits of dual versus monotherapy in people with CKD without diabetes?

Output: major kidneyoutcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the benefits of dual versus monotherapy in people with CKD without diabetes?. ### Response: major kidneyoutcomes.


Instruction: What has not been wellstudied in people with CKD without diabetes and proteinuria?

Output: The bene ﬁts of dual versus monotherapy on major kidneyoutcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has not been wellstudied in people with CKD without diabetes and proteinuria?. ### Response: The bene ﬁts of dual versus monotherapy on major kidneyoutcomes.


Instruction: What should be curtailing the risks of hyperkalemia and AKI?

Output: Future trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be curtailing the risks of hyperkalemia and AKI?. ### Response: Future trials.


Instruction: What should be directed to identify individuals who will bene fit or experience the benefits of personalized medicine?

Output: research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be directed to identify individuals who will bene fit or experience the benefits of personalized medicine?. ### Response: research.


Instruction: When did ACC/AHA/SCAI Focused Update on Primary PCI1243 occur?

Output: MARCH 15, 2016:1235 –50 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did ACC/AHA/SCAI Focused Update on Primary PCI1243 occur?. ### Response: MARCH 15, 2016:1235 –50 2015.


Instruction: How many people with essential hypertension had a stroke in December 2014?

Output: 9193

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people with essential hypertension had a stroke in December 2014?. ### Response: 9193.


Instruction: What was the duration of the stroke in 9193 people?

Output: 4 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the duration of the stroke in 9193 people?. ### Response: 4 years.


Instruction: How long did it take for BP reductions to be similar for each group?

Output: 305

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for BP reductions to be similar for each group?. ### Response: 305.


Instruction: How many people had diabetes mellitus?

Output: 5137

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people had diabetes mellitus?. ### Response: 5137.


Instruction: How much reduction was there in major vascular events?

Output: 24%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much reduction was there in major vascular events?. ### Response: 24%.


Instruction: What was the nonsignificant reduction in stroke among those treated?

Output: 21% reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the nonsignificant reduction in stroke among those treated?. ### Response: 21% reduction.


Instruction: What was the RR of stroke among those treated with the ARB?

Output: 0.79

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the RR of stroke among those treated with the ARB?. ### Response: 0.79.


Instruction: How many patients with type 2 diabetes mellitus had a fixed combination of perindopril and indapamide or matching pla-cebo?

Output: 11 140

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with type 2 diabetes mellitus had a fixed combination of perindopril and indapamide or matching pla-cebo?. ### Response: 11 140.


Instruction: What was the mean reduction in BP after 4.3 years of follow-up?

Output: 5.6/2.2 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean reduction in BP after 4.3 years of follow-up?. ### Response: 5.6/2.2 mm Hg.


Instruction: How much was the risk of a composite of major macrovascular and microvascu-lar events reduced by?

Output: 9%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much was the risk of a composite of major macrovascular and microvascu-lar events reduced by?. ### Response: 9%.


Instruction: How many antihypertensive treatment strategies were used in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT)?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many antihypertensive treatment strategies were used in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT)?. ### Response: 2.


Instruction: What was the HR of the ASCOT trial?

Output: 0.59

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the HR of the ASCOT trial?. ### Response: 0.59.


Instruction: How many patients with diabetes mellitus were compared to amlodipine-based or atenolol with addition of thiazide?

Output: 5137

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with diabetes mellitus were compared to amlodipine-based or atenolol with addition of thiazide?. ### Response: 5137.


Instruction: What was the target BP?

Output: <130/80 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the target BP?. ### Response: <130/80 mm Hg.


Instruction: Why was the trial terminated early?

Output: reductions in mortality and stroke with the amlodipine-based regimen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the trial terminated early?. ### Response: reductions in mortality and stroke with the amlodipine-based regimen.


Instruction: What did the amlodipine-based regimen reduce in deaths and strokes?

Output: incidence of total cardiovascular events and procedures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the amlodipine-based regimen reduce in deaths and strokes?. ### Response: incidence of total cardiovascular events and procedures.


Instruction: What was the difference in mortality and stroke reductions with the atenolol based regimen?

Output: 24% reduction (RR, 0.76; 95% CI, 0.58–0.98) in major vascular events and a nonsignificant 21% reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the difference in mortality and stroke reductions with the atenolol based regimen?. ### Response: 24% reduction (RR, 0.76; 95% CI, 0.58–0.98) in major vascular events and a nonsignificant 21% reduction.


Instruction: In patients with diabetes mellitus, what was the reduction in total cardiovascular events and procedures?

Output: the amlodipine-based therapy reduced the incidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with diabetes mellitus, what was the reduction in total cardiovascular events and procedures?. ### Response: the amlodipine-based therapy reduced the incidence.


Instruction: How much reduction in fatal and nonfatal strokes did the open-label therapy cause?

Output: 25%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much reduction in fatal and nonfatal strokes did the open-label therapy cause?. ### Response: 25%.


Instruction: What was the reduction in fatal and nonfatal strokes?

Output: 25%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the reduction in fatal and nonfatal strokes?. ### Response: 25%.


Instruction: How many participants were in the open-label ACCORD trial?

Output: 4733

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many participants were in the open-label ACCORD trial?. ### Response: 4733.


Instruction: What were the treatment goals for the more intensive and less intensive groups?

Output: 0.32% (more intensive) and 0.53%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the treatment goals for the more intensive and less intensive groups?. ### Response: 0.32% (more intensive) and 0.53%.


Instruction: What did not reduce the rate of the composite outcome of fatal and nonfatal major CVD events?

Output: Randomization to the more intensive goal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did not reduce the rate of the composite outcome of fatal and nonfatal major CVD events?. ### Response: Randomization to the more intensive goal.


Instruction: What was a prespecified secondary end point occur-ring at annual rates of 0.32%?

Output: Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a prespecified secondary end point occur-ring at annual rates of 0.32%?. ### Response: Stroke.


Instruction: How many patients were randomized to treatment with ACCOMPLISH?

Output: 11 506

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were randomized to treatment with ACCOMPLISH?. ### Response: 11 506.


Instruction: How many of the patients were with diabetes mellitus?

Output: 5137

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many of the patients were with diabetes mellitus?. ### Response: 5137.


Instruction: What was the average annual rate of more intensive and less intensive treatment?

Output: 0.32%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the average annual rate of more intensive and less intensive treatment?. ### Response: 0.32%.


Instruction: What was the primary end point of the study?

Output: <130/80 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary end point of the study?. ### Response: <130/80 mm Hg.


Instruction: What type of diabetes was randomized to benazepril plus amlodipine?

Output: mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diabetes was randomized to benazepril plus amlodipine?. ### Response: mellitus.


Instruction: What should be closely monitored during the introduction of aldosterone antagonists and during intercurrent illnesses?

Output: Plasma potassiumlevels and kidney function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be closely monitored during the introduction of aldosterone antagonists and during intercurrent illnesses?. ### Response: Plasma potassiumlevels and kidney function.


Instruction: What is associated with a risk of GFR reduction?

Output: dehydration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with a risk of GFR reduction?. ### Response: dehydration.


Instruction: What are aldosterone antagonists recommended for in patients without CKD?

Output: the treatment of severe cardiac failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are aldosterone antagonists recommended for in patients without CKD?. ### Response: the treatment of severe cardiac failure.


Instruction: What is used after acute myocardial infarction caused by cardiac failure?

Output: aldosterone antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used after acute myocardial infarction caused by cardiac failure?. ### Response: aldosterone antagonists.


Instruction: What is resistant to other therapies?

Output: essential hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is resistant to other therapies?. ### Response: essential hypertension.