Instruction: How is the new evidence consistent with our recommendations in AT9?

Output: increased DVT, decreased PE, and did notinﬂuence VTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the new evidence consistent with our recommendations in AT9?. ### Response: increased DVT, decreased PE, and did notinﬂuence VTE.


Instruction: In what subgroup of patients may an IVC filter not be recommended?

Output: anticoagulated patients with severe PE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what subgroup of patients may an IVC filter not be recommended?. ### Response: anticoagulated patients with severe PE.


Instruction: What is the name of the patient with severe PE with hypotension?

Output: anticoagulated

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the patient with severe PE with hypotension?. ### Response: anticoagulated.


Instruction: Why is it uncertain if there is bene fit to placement of anIVCfilter?

Output: may notapply to this select subgroup of patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is it uncertain if there is bene fit to placement of anIVCfilter?. ### Response: may notapply to this select subgroup of patients.


Instruction: Who may notapply to this select subgroup of patients?

Output: inpatients with acute PE who are anticoagulated

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who may notapply to this select subgroup of patients?. ### Response: inpatients with acute PE who are anticoagulated.


Instruction: What study has improved the quality of evidence for this recommendation?

Output: PREPIC 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What study has improved the quality of evidence for this recommendation?. ### Response: PREPIC 2.


Instruction: The AT10 panel decided against combining the results of what?

Output: TABLE 15 ]

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The AT10 panel decided against combining the results of what?. ### Response: TABLE 15 ].


Instruction: What are the Risk Factors for Bleeding with andContraindications to Use of ThrombolyticTherapy?

Output: Both Systemic and LocallyAdministered

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Risk Factors for Bleeding with andContraindications to Use of ThrombolyticTherapy?. ### Response: Both Systemic and LocallyAdministered.


Instruction: What is a major contraindicationsaStructural intracranial disease?

Output: Previous intracranial hemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a major contraindicationsaStructural intracranial disease?. ### Response: Previous intracranial hemorrhage.


Instruction: How long has there been aschemic stroke?

Output: more than 3 mo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long has there been aschemic stroke?. ### Response: more than 3 mo.


Instruction: What is the name of the non-intracranial procedure that has caused a stroke more than 3 mo previously?

Output: bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the non-intracranial procedure that has caused a stroke more than 3 mo previously?. ### Response: bleeding.


Instruction: What is another name for anticoagulated therapy?

Output: VKA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for anticoagulated therapy?. ### Response: VKA.


Instruction: How old is a woman when she is pregnant?

Output: >75 y

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old is a woman when she is pregnant?. ### Response: >75 y.


Instruction: What does the presence of major contraindications usually preclude?

Output: use of

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the presence of major contraindications usually preclude?. ### Response: use of.


Instruction: What is the ultimate goal of robotic CABG?

Output: totally endoscopic CABG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ultimate goal of robotic CABG?. ### Response: totally endoscopic CABG.


Instruction: Why has roboticCABG been limited?

Output: a substantial learning curve,cost considerations, and few data demonstrating noninferiorgraft patency and outcomes compared with standard CABG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why has roboticCABG been limited?. ### Response: a substantial learning curve,cost considerations, and few data demonstrating noninferiorgraft patency and outcomes compared with standard CABG.


Instruction: What may enable more routine applica-tion of totally endoscopic anastomoses?

Output: Anastomotic connectors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may enable more routine applica-tion of totally endoscopic anastomoses?. ### Response: Anastomotic connectors.


Instruction: What type of anastomoses are technically challenging when performed endoscopically?

Output: hand-sewn

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of anastomoses are technically challenging when performed endoscopically?. ### Response: hand-sewn.


Instruction: Why have anatomicconnectors been considered?

Output: to facilitate more reproducible and less technicallydemanding procedures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why have anatomicconnectors been considered?. ### Response: to facilitate more reproducible and less technicallydemanding procedures.


Instruction: What types of connectors are available?

Output: proximal and distal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What types of connectors are available?. ### Response: proximal and distal.


Instruction: What type of connectors may be used?

Output: proximal and distal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of connectors may be used?. ### Response: proximal and distal.


Instruction: What is the evidence base supporting PAS-Port proximal devices evolving?

Output: Several options are being developed, some only availableoutside the United States, and the evidence base supportingtheir use is evolving.1254The PAS-Port proximal device hasbeen associated with acceptable outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the evidence base supporting PAS-Port proximal devices evolving?. ### Response: Several options are being developed, some only availableoutside the United States, and the evidence base supportingtheir use is evolving.1254The PAS-Port proximal device hasbeen associated with acceptable outcomes.


Instruction: How long after CABG is graft patency similar to that of hand-sewn anastomoses?

Output: 9 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after CABG is graft patency similar to that of hand-sewn anastomoses?. ### Response: 9 months.


Instruction: What must be constructed with this device?

Output: proximal anastomoses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must be constructed with this device?. ### Response: proximal anastomoses.


Instruction: When was the ACCF/AHA CABG Guidelinee699Downloaded from http://ahajournals.org by?

Output: April 26, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the ACCF/AHA CABG Guidelinee699Downloaded from http://ahajournals.org by?. ### Response: April 26, 2023.


Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al.


Instruction: What is the name of the 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines?

Output: Otto et al 2020 ACC/AHA Guideline for the Management of Valvular Heart DiseaseCirculation. 2021;143:e72–e227. DOI: 10.1161/CIR.0000000000000923 February 2, 2021 e209CLINICAL STATEMENTS  AND GUIDELINESThrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines?. ### Response: Otto et al 2020 ACC/AHA Guideline for the Management of Valvular Heart DiseaseCirculation. 2021;143:e72–e227. DOI: 10.1161/CIR.0000000000000923 February 2, 2021 e209CLINICAL STATEMENTS  AND GUIDELINESThrombosis.


Instruction: What is the main cause of intracardiac thrombosis?

Output: patient-related and device-related factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the main cause of intracardiac thrombosis?. ### Response: patient-related and device-related factors.


Instruction: What is a lesson learned from GELIA?

Output: Intensity of oral anticoagulation af-ter implantation of St. Jude Medical mitral or multiple valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a lesson learned from GELIA?. ### Response: Intensity of oral anticoagulation af-ter implantation of St. Jude Medical mitral or multiple valve replacement.


Instruction: How did Pruefer D, Dahm M, Dohmen G, et al. assess the intensity of oral anticoagulation?

Output: Intensity of oral anticoagulation af-ter implantation of St. Jude Medical mitral or multiple valve replacement: lessons learned from GELIA (GELIA 5).

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Pruefer D, Dahm M, Dohmen G, et al. assess the intensity of oral anticoagulation?. ### Response: Intensity of oral anticoagulation af-ter implantation of St. Jude Medical mitral or multiple valve replacement: lessons learned from GELIA (GELIA 5)..


Instruction: What is GELIA 5?

Output: Intensity of oral anticoagulation af-ter implantation of St. Jude Medical mitral or multiple valve replacement: lessons learned from GELIA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is GELIA 5?. ### Response: Intensity of oral anticoagulation af-ter implantation of St. Jude Medical mitral or multiple valve replacement: lessons learned from GELIA.


Instruction: What is ARTE?

Output: Aspirin Ver -sus Aspirin + Clopidogrel Following Transcatheter Aortic Valve Implanta-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ARTE?. ### Response: Aspirin Ver -sus Aspirin + Clopidogrel Following Transcatheter Aortic Valve Implanta-tion.


Instruction: How is aspirin compared to clopidogrel?

Output: Aspirin Ver -sus Aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is aspirin compared to clopidogrel?. ### Response: Aspirin Ver -sus Aspirin.


Instruction: What is the name of the randomized clinical trial that followed transcatheter aortic valve implanta-tion?

Output: ARTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized clinical trial that followed transcatheter aortic valve implanta-tion?. ### Response: ARTE.


Instruction: What year was the JACC Cardiovasc Interv. 10:1357-65?

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the JACC Cardiovasc Interv. 10:1357-65?. ### Response: 2017.


Instruction: How many antiplatelet therapies have been performed after trans catheter valve replacement?

Output: Single or dual

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many antiplatelet therapies have been performed after trans catheter valve replacement?. ### Response: Single or dual.


Instruction: When will the J Thorac Dis. 11 be published?

Output: 2019

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When will the J Thorac Dis. 11 be published?. ### Response: 2019.


Instruction: What is the risk of thromboemboli early after bioprosthetic cardiac valve implanta-tion?

Output: High risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of thromboemboli early after bioprosthetic cardiac valve implanta-tion?. ### Response: High risk.


Instruction: What is a meta-analysis comparing single versus dual antiplatelet therapy?

Output: transcatheter aortic valve implanta-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a meta-analysis comparing single versus dual antiplatelet therapy?. ### Response: transcatheter aortic valve implanta-tion.


Instruction: What is the risk of thromboemboli early after a bioprosthetic cardiac valve replacement?

Output: High

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of thromboemboli early after a bioprosthetic cardiac valve replacement?. ### Response: High.


Instruction: What was the J Am Coll Cardiol. 1995;25:1111–9.

Output: bioprosthetic cardiac valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the J Am Coll Cardiol. 1995;25:1111–9.. ### Response: bioprosthetic cardiac valve replacement.


Instruction: What did Colli A, Mestres CA, Castella M, et al. compare to warfarin after?

Output: aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Colli A, Mestres CA, Castella M, et al. compare to warfarin after?. ### Response: aspirin.


Instruction: What was the name of the pilot trial that resulted in heart valve bioprosthesis?

Output: WoA Epic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the pilot trial that resulted in heart valve bioprosthesis?. ### Response: WoA Epic.


Instruction: What is the name given to triflusal versus oral an-ticoagulation for primary prevention of thromboembolism?

Output: TRAC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name given to triflusal versus oral an-ticoagulation for primary prevention of thromboembolism?. ### Response: TRAC.


Instruction: What is a co-operative trial?

Output: Triflusal versus oral an-ticoagulation for primary prevention of thromboembolism after biopros-thetic valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a co-operative trial?. ### Response: Triflusal versus oral an-ticoagulation for primary prevention of thromboembolism after biopros-thetic valve replacement.


Instruction: What is the name of the study that aimed to prevent thromboembolism using aspirin after mitral valve replacement with porcine bioprosthesis?

Output: WoA Epic pilot trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that aimed to prevent thromboembolism using aspirin after mitral valve replacement with porcine bioprosthesis?. ### Response: WoA Epic pilot trial.


Instruction: What is the name of the study that describes modern management of prosthetic valve anticoagulation?

Output: Mayo Clin Proc

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that describes modern management of prosthetic valve anticoagulation?. ### Response: Mayo Clin Proc.


Instruction: When was the Mayo Clin Proc. 73:665-80?

Output: 1998

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Mayo Clin Proc. 73:665-80?. ### Response: 1998.


Instruction: What is a risk of mortality, thromboembolic complications, and bleeding after bioprosthetic aortic valve replacement?

Output: Association of warfarin ther -apy duration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk of mortality, thromboembolic complications, and bleeding after bioprosthetic aortic valve replacement?. ### Response: Association of warfarin ther -apy duration.


Instruction: What is thromboembolic complications after surgical correction of mitral regurgitation incidence, predictors, and clinical implications?

Output: Intracardiac thrombosis: patient-related and device-related factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is thromboembolic complications after surgical correction of mitral regurgitation incidence, predictors, and clinical implications?. ### Response: Intracardiac thrombosis: patient-related and device-related factors.


Instruction: What is aortic stenosis: disease severity, progression, and timing and type of intervention?

Output: Low-output, low-gra-dient aortic stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is aortic stenosis: disease severity, progression, and timing and type of intervention?. ### Response: Low-output, low-gra-dient aortic stenosis.


Instruction: What is the name of the 6th ed. of The Practice of Clinical Echocardiography?

Output: Otto CM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 6th ed. of The Practice of Clinical Echocardiography?. ### Response: Otto CM.


Instruction: Where is Otto CM located?

Output: Philadelphia, PA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Otto CM located?. ### Response: Philadelphia, PA.


Instruction: What is low-output, low-gra-dient aortic stenosis in patients with depressed left ventricular systolic?

Output: Low-output, low-gra-dient aortic stenosis in patients with depressed left ventricular systolic Downloaded from http://ahajournals.org by on April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is low-output, low-gra-dient aortic stenosis in patients with depressed left ventricular systolic?. ### Response: Low-output, low-gra-dient aortic stenosis in patients with depressed left ventricular systolic Downloaded from http://ahajournals.org by on April 28, 2023.


Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al.


Instruction: What is the cause of transvalvular, caused by leaflet immobility?

Output: calcification

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cause of transvalvular, caused by leaflet immobility?. ### Response: calcification.


Instruction: What is focal calcification?

Output: leaflet perforation or flail

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is focal calcification?. ### Response: leaflet perforation or flail.


Instruction: What are the defini-tions of prosthetic valve regurgitation severity published by?

Output: hemody-namic effects, and etiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the defini-tions of prosthetic valve regurgitation severity published by?. ### Response: hemody-namic effects, and etiology.


Instruction: Where are references to studies that support the recommendations summarized?

Output: Online Data Supplement 41.COR LOE Recommendations1 B-NR1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are references to studies that support the recommendations summarized?. ### Response: Online Data Supplement 41.COR LOE Recommendations1 B-NR1.


Instruction: What are TTE and TEE recommended to determine in patients with suspected mechanical or bioprosthetic valve regurgitation?

Output: the cause and severity of the leak

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are TTE and TEE recommended to determine in patients with suspected mechanical or bioprosthetic valve regurgitation?. ### Response: the cause and severity of the leak.


Instruction: What is TTE recommended to assess?

Output: ventricular function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is TTE recommended to assess?. ### Response: ventricular function.


Instruction: In patients undergoing a transcatheter procedure, what is 3D recommended?

Output: intraprocedural guidance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients undergoing a transcatheter procedure, what is 3D recommended?. ### Response: intraprocedural guidance.


Instruction: How do patients evaluate pulmonary artery systolic pressure?

Output: TTE and TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do patients evaluate pulmonary artery systolic pressure?. ### Response: TTE and TEE.


Instruction: What is recommended for intraprocedural guidance for patients undergoing a transcatheter procedure for paravalvular prosthetic regurgitation?

Output: 3D TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for intraprocedural guidance for patients undergoing a transcatheter procedure for paravalvular prosthetic regurgitation?. ### Response: 3D TEE.


Instruction: What varies depending on its severity, hemody-namic effects, and etiology?

Output: The clinical presentation of prosthetic valve regur -gitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What varies depending on its severity, hemody-namic effects, and etiology?. ### Response: The clinical presentation of prosthetic valve regur -gitation.


Instruction: What should prompt suspicion of prosthetic valve dysfunction?

Output: A change in auscultatory findings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should prompt suspicion of prosthetic valve dysfunction?. ### Response: A change in auscultatory findings.


Instruction: What type of patients present with unexplained or new-onset HF or significant hemolysis?

Output: Symptomatic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of patients present with unexplained or new-onset HF or significant hemolysis?. ### Response: Symptomatic.


Instruction: What is inadequate for evaluation of prosthetic mitral valves?

Output: TTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is inadequate for evaluation of prosthetic mitral valves?. ### Response: TTE.


Instruction: What is needed when prosthetic MR is a concern?

Output: TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed when prosthetic MR is a concern?. ### Response: TEE.


Instruction: A critical step in evaluation of the patient with prosthetic valve regurgitation is to distinguish transval-vular from what?

Output: paravalvular leak

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A critical step in evaluation of the patient with prosthetic valve regurgitation is to distinguish transval-vular from what?. ### Response: paravalvular leak.


Instruction: To distinguish transval-vular from paravalvular leak, what requires TEE in addition to TTE?

Output: pros-thetic valve regurgitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: To distinguish transval-vular from paravalvular leak, what requires TEE in addition to TTE?. ### Response: pros-thetic valve regurgitation.


Instruction: What is the management of prosthetic valve stenosis and regurgitation?

Output: Figure 14

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the management of prosthetic valve stenosis and regurgitation?. ### Response: Figure 14.


Instruction: What is the acronym for transesophageal echocardiography?

Output: TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for transesophageal echocardiography?. ### Response: TEE.


Instruction: What is TTE?

Output: transthoracic echocardiography/echocardiogram

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is TTE?. ### Response: transthoracic echocardiography/echocardiogram.


Instruction: What is the average age of onset of aSAH in adults?

Output: 1135050 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the average age of onset of aSAH in adults?. ### Response: 1135050 years of age.


Instruction: What is relatively uncommon in children?

Output: aSAH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is relatively uncommon in children?. ### Response: aSAH.


Instruction: As children get older, what is the rate of incidence of ASD?

Output: 0.18 to 2.0 per100 000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: As children get older, what is the rate of incidence of ASD?. ### Response: 0.18 to 2.0 per100 000.


Instruction: How many studies have shown that the incidence ofaSD increases with age?

Output: 1.6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies have shown that the incidence ofaSD increases with age?. ### Response: 1.6.


Instruction: How many times higher is the incidence of aSAH in women than in men?

Output: 1.24

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many times higher is the incidence of aSAH in women than in men?. ### Response: 1.24.


Instruction: What is the previous estimate of the incidence in women?

Output: 1.6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the previous estimate of the incidence in women?. ### Response: 1.6.


Instruction: What was the previous estimate for the years 1960 to 1994?

Output: 1.6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the previous estimate for the years 1960 to 1994?. ### Response: 1.6.


Instruction: What is the confidence interval between 1.1 and 2.3?

Output: 95%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the confidence interval between 1.1 and 2.3?. ### Response: 95%.


Instruction: What is the age range between 55 and 85 years of age?

Output: women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the age range between 55 and 85 years of age?. ### Response: women.


Instruction: What are the differences in incidence of aSAH by race and ethnicity?

Output: appear to exist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the differences in incidence of aSAH by race and ethnicity?. ### Response: appear to exist.


Instruction: When did Stroke June 2012 occur?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Stroke June 2012 occur?. ### Response: April 28, 2023.


Instruction: What is the name of the prospective trial of Intravenous Streptoki-nase in Acute Myocardial infarction?

Output: The I.S.A.M. Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective trial of Intravenous Streptoki-nase in Acute Myocardial infarction?. ### Response: The I.S.A.M. Study Group.


Instruction: What was the mortality, morbidity, and infarct size at 21 days of I.S.A.M.?

Output: Intravenous Streptoki-nase in Acute Myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mortality, morbidity, and infarct size at 21 days of I.S.A.M.?. ### Response: Intravenous Streptoki-nase in Acute Myocardial infarction.


Instruction: When was the N Engl J Med 314:1465–71.312?

Output: 1986

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the N Engl J Med 314:1465–71.312?. ### Response: 1986.


Instruction: What is added to conventional therapy in patients with ischemic cardiac pain at rest?

Output: tissue-type plasminogen activator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is added to conventional therapy in patients with ischemic cardiac pain at rest?. ### Response: tissue-type plasminogen activator.


Instruction: What is the name of the Thrombolysis in Myocardial Ischemia Trial?

Output: TIMI IIIA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Thrombolysis in Myocardial Ischemia Trial?. ### Response: TIMI IIIA.


Instruction: When was the TIMI IIIA Trial conducted?

Output: 1993

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the TIMI IIIA Trial conducted?. ### Response: 1993.


Instruction: What is the prognostic value of lead aVR in patients with a first non-ST-segment elevation acute myocardial infarc-tion?

Output: 108:814–9.314

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the prognostic value of lead aVR in patients with a first non-ST-segment elevation acute myocardial infarc-tion?. ### Response: 108:814–9.314.


Instruction: When did Circulation. 2003;108:814–9.314.

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circulation. 2003;108:814–9.314.. ### Response: 2003.


Instruction: What is recombinant plasminogen activator?

Output: double-bolus reteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recombinant plasminogen activator?. ### Response: double-bolus reteplase.


Instruction: What is recombinant tissue plasminogen activator?

Output: alteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recombinant tissue plasminogen activator?. ### Response: alteplase.


Instruction: What is front-loaded, acceler -ated alteplase?

Output: recombinant tissue plasminogen activator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is front-loaded, acceler -ated alteplase?. ### Response: recombinant tissue plasminogen activator.


Instruction: When did Circulation. 1996;94:891–8.315?

Output: 1996

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circulation. 1996;94:891–8.315?. ### Response: 1996.


Instruction: ISIS-3 is the third international study of what?

Output: Infarct Survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ISIS-3 is the third international study of what?. ### Response: Infarct Survival.


Instruction: How many cases of suspected acute myocardial infarction were treated with anistreplase and of aspirin plus heparin vs aspirine alone?

Output: 41,299

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many cases of suspected acute myocardial infarction were treated with anistreplase and of aspirin plus heparin vs aspirine alone?. ### Response: 41,299.


Instruction: What is the GUS-TO III Investigators' name?

Output: Global Use of Strategies to Open Occluded Coronary Arteries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the GUS-TO III Investigators' name?. ### Response: Global Use of Strategies to Open Occluded Coronary Arteries.


Instruction: What is GUS-TO III?

Output: Global Use of Strategies to Open Occluded Coronary Arteries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is GUS-TO III?. ### Response: Global Use of Strategies to Open Occluded Coronary Arteries.


Instruction: What is reteplase compared to?

Output: alteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reteplase compared to?. ### Response: alteplase.


Instruction: How many thrombolytic strategies did the GUSTO Investigators compare?

Output: four

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many thrombolytic strategies did the GUSTO Investigators compare?. ### Response: four.


Instruction: What is the difference between single-bolus tenecteplase and front-loaded alteplased in acute myocardial infarction: the ASSENT-2 double-blind randomised trial?

Output: Single-bolus tenecteplase compared with front-loaded alteplase in acute myocardial infarction: the ASSENT-2 double-blind randomised trial. Lancet. 1999;354:716–22.320. Wilcox RG, von der Lippe G, Olsson CG, et al. Trial of tissue plasminogen activator for mortality reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between single-bolus tenecteplase and front-loaded alteplased in acute myocardial infarction: the ASSENT-2 double-blind randomised trial?. ### Response: Single-bolus tenecteplase compared with front-loaded alteplase in acute myocardial infarction: the ASSENT-2 double-blind randomised trial. Lancet. 1999;354:716–22.320. Wilcox RG, von der Lippe G, Olsson CG, et al. Trial of tissue plasminogen activator for mortality reduction.


Instruction: What is a potential benefit of tissue plasminogen activator for mortality reduction?

Output: serum troponin I elevation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a potential benefit of tissue plasminogen activator for mortality reduction?. ### Response: serum troponin I elevation.


Instruction: What is ASSET?

Output: Anglo-Scan-dinavian Study of Early Thrombolysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ASSET?. ### Response: Anglo-Scan-dinavian Study of Early Thrombolysis.


Instruction: What does ASSET stand for?

Output: Anglo-Scan-dinavian Study of Early Thrombolysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ASSET stand for?. ### Response: Anglo-Scan-dinavian Study of Early Thrombolysis.


Instruction: When was ASSET published?

Output: 1988

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was ASSET published?. ### Response: 1988.


Instruction: How did ASSET compare to other studies?

Output: double-blind randomised trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did ASSET compare to other studies?. ### Response: double-blind randomised trial.


Instruction: What is the ascending aorta called?

Output: aortic dissection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ascending aorta called?. ### Response: aortic dissection.


Instruction: What are the investigators of the LATE study?

Output: Langer A, Goodman SG, Topol EJ, et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the investigators of the LATE study?. ### Response: Langer A, Goodman SG, Topol EJ, et al.


Instruction: When was the Late study conducted?

Output: 1996

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Late study conducted?. ### Response: 1996.


Instruction: How many patients had non-Q wave myocardial infarction?

Output: 32.323

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had non-Q wave myocardial infarction?. ### Response: 32.323.


Instruction: What is the name of the group that studies the effects of tissue plasmino-immunotherapy?

Output: GUSTO Angiographic Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that studies the effects of tissue plasmino-immunotherapy?. ### Response: GUSTO Angiographic Investigators.


Instruction: What type of therapy is used in patients with acute myocardial infarction?

Output: Bolus fibrinolytic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is used in patients with acute myocardial infarction?. ### Response: Bolus fibrinolytic.


Instruction: Who is the Head of the Department of Medicine at Dunedin School ofMedicine, University of Otago?

Output: Robert J Walker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Head of the Department of Medicine at Dunedin School ofMedicine, University of Otago?. ### Response: Robert J Walker.


Instruction: Who is Robert Walker a ConsultantNephrologist and Head of Nephrologyat Healthcare Otag?

Output: Robert J Walker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Robert Walker a ConsultantNephrologist and Head of Nephrologyat Healthcare Otag?. ### Response: Robert J Walker.


Instruction: What is Dr Walker's interests in?

Output: renal hemodynamics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Dr Walker's interests in?. ### Response: renal hemodynamics.


Instruction: What is the broad base of translational renal research with interests in renal pharmacology, renal pathophysiology, and drugnephrotoxicity?

Output: Robert J Walker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the broad base of translational renal research with interests in renal pharmacology, renal pathophysiology, and drugnephrotoxicity?. ### Response: Robert J Walker.


Instruction: What is linked to the ongoing clinical research interests in the regulation of renal and cardiovascular hemodynamics?

Output: renal pharmacology, renal pathophysiology and drugnephrotoxicity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is linked to the ongoing clinical research interests in the regulation of renal and cardiovascular hemodynamics?. ### Response: renal pharmacology, renal pathophysiology and drugnephrotoxicity.


Instruction: How many publications did Dr Walker have?

Output: 180

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many publications did Dr Walker have?. ### Response: 180.


Instruction: How many pivotal trials has Dr Walker participated in?

Output: a number of pivotal trialsincluding IDEAL, SHARP , ASFAST, and PERFECT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many pivotal trials has Dr Walker participated in?. ### Response: a number of pivotal trialsincluding IDEAL, SHARP , ASFAST, and PERFECT.


Instruction: What was Dr Walker active in until 2011?

Output: Scientiﬁc Programme and Education Commit-tee for the ANZSN

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was Dr Walker active in until 2011?. ### Response: Scientiﬁc Programme and Education Commit-tee for the ANZSN.


Instruction: How many publications did Professor Walker write?

Output: 180

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many publications did Professor Walker write?. ### Response: 180.


Instruction: What committees does Professor Walker serve on?

Output: ISNNexus and Forefronts Committees

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What committees does Professor Walker serve on?. ### Response: ISNNexus and Forefronts Committees.


Instruction: In what year was Professor Walker active in the Scientific Programme and Education Commit-tee?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was Professor Walker active in the Scientific Programme and Education Commit-tee?. ### Response: 2011.


Instruction: Who is an Executive Council member of theAsian Pacific Society of Nephrology?

Output: Professor Walker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is an Executive Council member of theAsian Pacific Society of Nephrology?. ### Response: Professor Walker.


Instruction: Who has a strong interest in developing links between Australia & New Zealand?

Output: Professor Walker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who has a strong interest in developing links between Australia & New Zealand?. ### Response: Professor Walker.


Instruction: What country has a strong interest in developing links with SouthEast Asia and the Pacific?

Output: Australia & New Zealand

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What country has a strong interest in developing links with SouthEast Asia and the Pacific?. ### Response: Australia & New Zealand.


Instruction: Who is Professor of Medicine at the University of Minnesota, USA?

Output: KDIGO CHAIRSBertram L Kasiske

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Professor of Medicine at the University of Minnesota, USA?. ### Response: KDIGO CHAIRSBertram L Kasiske.


Instruction: Where did Dr. Kasiske receive his medical degree?

Output: University of Iowa

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where did Dr. Kasiske receive his medical degree?. ### Response: University of Iowa.


Instruction: Who is the former Deputy Director of the United States Renal Data System?

Output: Dr Kasiske

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the former Deputy Director of the United States Renal Data System?. ### Response: Dr Kasiske.


Instruction: What was the former Editor-in-Chief of American Journal of KidneyDiseases?

Output: Dr Kasiske

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the former Editor-in-Chief of American Journal of KidneyDiseases?. ### Response: Dr Kasiske.


Instruction: Who has served on the Board of Directors of the American Society of Transplantation?

Output: Dr Kasiske

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who has served on the Board of Directors of the American Society of Transplantation?. ### Response: Dr Kasiske.


Instruction: Who is currently serving on the Board of Councilors of the ISN?

Output: Dr Kasiske

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is currently serving on the Board of Councilors of the ISN?. ### Response: Dr Kasiske.


Instruction: Who is the PI for a study of long-term outcomes after kidney donation?

Output: Dr Kasiske

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the PI for a study of long-term outcomes after kidney donation?. ### Response: Dr Kasiske.


Instruction: Who is the Director of the ScientificRegistry of Transplant Recipients?

Output: Dr Kasiske

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Director of the ScientificRegistry of Transplant Recipients?. ### Response: Dr Kasiske.


Instruction: How many scientificpublications does Dr Kasiske have?

Output: over 160

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many scientificpublications does Dr Kasiske have?. ### Response: over 160.


Instruction: What award did Dr Kasiske receive in 2003?

Output: Garabed Eknoyan Award

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What award did Dr Kasiske receive in 2003?. ### Response: Garabed Eknoyan Award.


Instruction: What is NICE 2018?

Output: Chronic Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE 2018?. ### Response: Chronic Heart Failure.


Instruction: What is the name of the study that compares telemonitoring to usual care?

Output: A single study (n=1437

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that compares telemonitoring to usual care?. ### Response: A single study (n=1437.


Instruction: How many studies were included for the outcome all -cause mortality?

Output: 9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were included for the outcome all -cause mortality?. ### Response: 9.


Instruction: What was low quality and showed a clinically important reduction in deaths?

Output: all -cause mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was low quality and showed a clinically important reduction in deaths?. ### Response: all -cause mortality.


Instruction: How many studies did the outcome all -cause hospitalisation contain?

Output: 6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies did the outcome all -cause hospitalisation contain?. ### Response: 6.


Instruction: What was a significant level of heterogeneity (I2=83%)?

Output: outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a significant level of heterogeneity (I2=83%)?. ### Response: outcome.


Instruction: What was I2=83%), unexplained by subgroup analysis for age, year of publication and intensity of intervention?

Output: heterogeneity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was I2=83%), unexplained by subgroup analysis for age, year of publication and intensity of intervention?. ### Response: heterogeneity.


Instruction: What was taken into consideration when judging the quality of the evidence?

Output: heterogeneity (I2=55%), unexplained by subgroup analysis for age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was taken into consideration when judging the quality of the evidence?. ### Response: heterogeneity (I2=55%), unexplained by subgroup analysis for age.


Instruction: For the outcome QoL the evidence ranged from high to what?

Output: very low quality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For the outcome QoL the evidence ranged from high to what?. ### Response: very low quality.


Instruction: What scales showed no clinical effect?

Output: MLWHF t

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What scales showed no clinical effect?. ### Response: MLWHF t.


Instruction: What scale showed a clinically important improvement in QoL?

Output: SF -36

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What scale showed a clinically important improvement in QoL?. ### Response: SF -36.


Instruction: How did the mental component summary compare to the SF-36 scale?

Output: there was evidence of a clinically important reduction in QoL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did the mental component summary compare to the SF-36 scale?. ### Response: there was evidence of a clinically important reduction in QoL.


Instruction: What component of QoL showed no clinical effect?

Output: physical

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What component of QoL showed no clinical effect?. ### Response: physical.


Instruction: How many studies reported all -cause mortality alone?

Output: n=20

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies reported all -cause mortality alone?. ### Response: n=20.


Instruction: What was the quality of the evidence?

Output: very low quality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the quality of the evidence?. ### Response: very low quality.


Instruction: What was low quality and did not demonstrate a clear effect with the confidence interval?

Output: The evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was low quality and did not demonstrate a clear effect with the confidence interval?. ### Response: The evidence.


Instruction: How many studies were included in the outcome all -cause hospitalisation?

Output: 6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were included in the outcome all -cause hospitalisation?. ### Response: 6.


Instruction: What was the confidence interval ranging from a decrease and increase in all cause mortality?

Output: low quality and did not demonstrate a clear effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the confidence interval ranging from a decrease and increase in all cause mortality?. ### Response: low quality and did not demonstrate a clear effect.


Instruction: What was I2=55%)?

Output: heterogeneity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was I2=55%)?. ### Response: heterogeneity.


Instruction: For the outcome QoL the evidence ranged from low to what?

Output: very low quality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For the outcome QoL the evidence ranged from low to what?. ### Response: very low quality.


Instruction: What component of the SF -36 showed evidence of a clinically important improvement in QoL?

Output: physical functioning

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What component of the SF -36 showed evidence of a clinically important improvement in QoL?. ### Response: physical functioning.


Instruction: For the mental component summary, there was evidence of what?

Output: a clinically important reduction in QoL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For the mental component summary, there was evidence of what?. ### Response: a clinically important reduction in QoL.


Instruction: What is a clinically important reduction in QoL?

Output: mental component summary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a clinically important reduction in QoL?. ### Response: mental component summary.


Instruction: For the scale MLWHF t here was no evidence of a what?

Output: clinical effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For the scale MLWHF t here was no evidence of a what?. ### Response: clinical effect.


Instruction: Telemonitoring + structured telephone support Recent admission A single study looked at the effect of telemonitoring in addition to what other support?

Output: structured telephone support

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Telemonitoring + structured telephone support Recent admission A single study looked at the effect of telemonitoring in addition to what other support?. ### Response: structured telephone support.


Instruction: What was the outcome all -cause mortality (low quality)?

Output: there was evidence of a clinically important reduction in deaths

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome all -cause mortality (low quality)?. ### Response: there was evidence of a clinically important reduction in deaths.


Instruction: What was evidence of a clinically important reduction in deaths?

Output: low quality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was evidence of a clinically important reduction in deaths?. ### Response: low quality.


Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al.


Instruction: When was the 2021 Circulation. 2021:143:e72–e227?

Output: February 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the 2021 Circulation. 2021:143:e72–e227?. ### Response: February 2.


Instruction: What are the patients least amenable to percutaneous treatment?

Output: GUIDELINES

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the patients least amenable to percutaneous treatment?. ### Response: GUIDELINES.


Instruction: What is the SYNTAX score?

Output: >33.3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the SYNTAX score?. ### Response: >33.3.


Instruction: What is reasonable in this subset of patients?

Output: a surgical approach

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable in this subset of patients?. ### Response: a surgical approach.


Instruction: Revascularization for SAVR patients has been shown to impact late risk of mortality favorably?

Output: CAD (>50% stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Revascularization for SAVR patients has been shown to impact late risk of mortality favorably?. ### Response: CAD (>50% stenosis.


Instruction: What is shown to impact late risk of mortality favorably?

Output: revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is shown to impact late risk of mortality favorably?. ### Response: revascularization.


Instruction: What is summarized in Online Data Supplement 45.COR LOE Recommendations1 C-LD1.

Output: Referenced studies that support the recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is summarized in Online Data Supplement 45.COR LOE Recommendations1 C-LD1.. ### Response: Referenced studies that support the recommendations.


Instruction: What is indicated before valve intervention in patients with symptoms of angina?

Output: invasive coronary angiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is indicated before valve intervention in patients with symptoms of angina?. ### Response: invasive coronary angiography.


Instruction: In patients with chronic severe secondary MR, invasive coronary angiography is indicated what?

Output: before valve intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with chronic severe secondary MR, invasive coronary angiography is indicated what?. ### Response: before valve intervention.


Instruction: What should be performed in patients with chronic severe secondary MR?

Output: invasive coronary angiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be performed in patients with chronic severe secondary MR?. ### Response: invasive coronary angiography.


Instruction: In patients with low to intermediate pretest probability of CAD, contrast-enhanced coronary CT angiography is reasonable to exclude the presence of what?

Output: significant obstructive CAD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with low to intermediate pretest probability of CAD, contrast-enhanced coronary CT angiography is reasonable to exclude the presence of what?. ### Response: significant obstructive CAD.


Instruction: What is CABG reasonable for in patients undergoing valve repair or replacement with significant proximal CAD?

Output: selective patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CABG reasonable for in patients undergoing valve repair or replacement with significant proximal CAD?. ### Response: selective patients.


Instruction: What percentage reduction in luminal diameter in major coronary arteries or physiological significance is considered to be reasonable?

Output: ≥70%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage reduction in luminal diameter in major coronary arteries or physiological significance is considered to be reasonable?. ### Response: ≥70%.


Instruction: What is reasonable for selective patients?

Output: a surgical approach

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable for selective patients?. ### Response: a surgical approach.


Instruction: What defines anat-omy that may be at risk during surgery or interven-tion?

Output: Coronary imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What defines anat-omy that may be at risk during surgery or interven-tion?. ### Response: Coronary imaging.


Instruction: What type of MR has a pathophysiological link?

Output: sec-ondary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of MR has a pathophysiological link?. ### Response: sec-ondary.


Instruction: What can impact periprocedural risk or long-term outcome?

Output: Re-vascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can impact periprocedural risk or long-term outcome?. ### Response: Re-vascularization.


Instruction: In the case of secondary MR, revascularization may positively impact the valve dis-ease via what?

Output: reverse remodeling of the LV

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the case of secondary MR, revascularization may positively impact the valve dis-ease via what?. ### Response: reverse remodeling of the LV.


Instruction: In a surgical setting, where repeat intervention is at high cost to the patient, what is typically made to correct all surgically correctable disease present at the index op-eration?

Output: an aggressive approach to revas-cularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In a surgical setting, where repeat intervention is at high cost to the patient, what is typically made to correct all surgically correctable disease present at the index op-eration?. ### Response: an aggressive approach to revas-cularization.


Instruction: An aggressive approach to revas-cularization is appropriate in what setting?

Output: surgical setting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: An aggressive approach to revas-cularization is appropriate in what setting?. ### Response: surgical setting.


Instruction: In the setting of percutaneous interventions, what option is available?

Output: sequential interventions with interval tests of improvement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the setting of percutaneous interventions, what option is available?. ### Response: sequential interventions with interval tests of improvement.


Instruction: What is often present among patients with coronary artery disease?

Output: CAD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is often present among patients with coronary artery disease?. ### Response: CAD.


Instruction: What type of imaging is in-creasingly adopted?

Output: less invasive imaging via contrast-enhanced coronary CT angiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of imaging is in-creasingly adopted?. ### Response: less invasive imaging via contrast-enhanced coronary CT angiography.


Instruction: What is the abbreviated therapeutic approach to Wolff-Parkinson-White syndrome?

Output: Radiofrequency catheter ablation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the abbreviated therapeutic approach to Wolff-Parkinson-White syndrome?. ### Response: Radiofrequency catheter ablation.


Instruction: How many patients were treated with radiofrequency catheter ablation?

Output: 508

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with radiofrequency catheter ablation?. ### Response: 508.


Instruction: How many patients had connections?

Output: 250

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had connections?. ### Response: 250.


Instruction: When was the Circulation.85:1337-46.

Output: 1992

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circulation.85:1337-46.. ### Response: 1992.


Instruction: What was the outcome after successful ra-diofrequency catheter abla-tion of accessory pathways?

Output: Late clinical outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome after successful ra-diofrequency catheter abla-tion of accessory pathways?. ### Response: Late clinical outcome.


Instruction: How long was the radiofrequency ablation of accessory pathways at Tel Aviv Medical Center?

Output: 14 year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the radiofrequency ablation of accessory pathways at Tel Aviv Medical Center?. ### Response: 14 year.


Instruction: How many patients were treated at the Isr Med Assoc J.?

Output: 508

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated at the Isr Med Assoc J.?. ### Response: 508.


Instruction: How many patients were treated at Aviv Medical Center?

Output: 508

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated at Aviv Medical Center?. ### Response: 508.


Instruction: What is the name of the journal that published the study?

Output: ahajournals.org

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that published the study?. ### Response: ahajournals.org.


Instruction: When was the study published?

Output: April 23, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the study published?. ### Response: April 23, 2023.


Instruction: No RCTs of IV alteplase in AIS with baseline MRI to identify CMBs have been conducted to identify what?

Output: no determination of the effect of baseline CMB on the treatment effect of alteplase with CMB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No RCTs of IV alteplase in AIS with baseline MRI to identify CMBs have been conducted to identify what?. ### Response: no determination of the effect of baseline CMB on the treatment effect of alteplase with CMB.


Instruction: No determination of the effect of baseline CMB on the treatment effect is available what is there no direct evidence of?

Output: IV alteplase provides no benefit or produces harm in eligible patients with CMBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No determination of the effect of baseline CMB on the treatment effect is available what is there no direct evidence of?. ### Response: IV alteplase provides no benefit or produces harm in eligible patients with CMBs.


Instruction: What does IV alteplase provide in patients with CMBs?

Output: no benefit or produces harm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does IV alteplase provide in patients with CMBs?. ### Response: no benefit or produces harm.


Instruction: What could lead to the exclusion of patients who would benefit from treatment?

Output: withholding treatment on the basis of the presence of CMBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could lead to the exclusion of patients who would benefit from treatment?. ### Response: withholding treatment on the basis of the presence of CMBs.


Instruction: What is the name of the online supplement?

Output: Data Supplement 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the online supplement?. ### Response: Data Supplement 1.


Instruction: When was Data Supplement 1 downloaded?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Data Supplement 1 downloaded?. ### Response: April 28, 2023.


Instruction: Acute kidney injury MACE/H11005major adverse coronary events?

Output: ARB/H11005angiotensin-receptor blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Acute kidney injury MACE/H11005major adverse coronary events?. ### Response: ARB/H11005angiotensin-receptor blockers.


Instruction: Angiotensin-receptor blockers MI / H11005myocardial infarctionBMS / HA11005bare-metal stent NSTEMI /H11105coronary artery bypass graft surgery PAC/H10905pulmonary artery catheterCAD/H10805coronal artery disease PAD /Ho11105peripheral artery diseasesCKD/Ho10805dual antiplatelet therapy

Output: H11005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Angiotensin-receptor blockers MI / H11005myocardial infarctionBMS / HA11005bare-metal stent NSTEMI /H11105coronary artery bypass graft surgery PAC/H10905pulmonary artery catheterCAD/H10805coronal artery disease PAD /Ho11105peripheral artery diseasesCKD/Ho10805dual antiplatelet therapy. ### Response: H11005.


Instruction: What is the name of the randomized controlled trial in H11005?

Output: DAPT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized controlled trial in H11005?. ### Response: DAPT.


Instruction: What type of therapy is used to treat ischemic heart disease?

Output: dual antiplatelet therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is used to treat ischemic heart disease?. ### Response: dual antiplatelet therapy.


Instruction: What is the ACCF/AHA CABG Guideline e735Downloaded from http://ahajournals.org by on April 26, 2023?

Output: Hillis et al 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ACCF/AHA CABG Guideline e735Downloaded from http://ahajournals.org by on April 26, 2023?. ### Response: Hillis et al 2011.


Instruction: What should be included in theregimen if urine ACR 430 mg/mmol(4300 mg/g)?

Output: DM, CKD o130/80 Non-DKD:ACE-I or ARB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be included in theregimen if urine ACR 430 mg/mmol(4300 mg/g)?. ### Response: DM, CKD o130/80 Non-DKD:ACE-I or ARB.


Instruction: ACE-I, ARB, thiazides, long-acting CCB, or beta-blockers are included in what?

Output: the regimen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ACE-I, ARB, thiazides, long-acting CCB, or beta-blockers are included in what?. ### Response: the regimen.


Instruction: What should be included in the regimen ifurine ACR o30 mg/mmol ( o300 mg/g)?

Output: DKD:ACE-I or ARB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be included in the regimen ifurine ACR o30 mg/mmol ( o300 mg/g)?. ### Response: DKD:ACE-I or ARB.


Instruction: How should ACE-I or ARB be includedin the regimen?

Output: if urine ACR 430 mg/mmol(4300 mg/g)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How should ACE-I or ARB be includedin the regimen?. ### Response: if urine ACR 430 mg/mmol(4300 mg/g).


Instruction: What should be the first choice of therapy for those with urine proteinZ1 g/d?

Output: target o125/75ACE-I or ARB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be the first choice of therapy for those with urine proteinZ1 g/d?. ### Response: target o125/75ACE-I or ARB.


Instruction: How should dose be titrated by urinaryalbumin excretion?

Output: For those with urine proteinZ1 g/d: target o125/75ACE-I or ARB should be the first choice oftherapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How should dose be titrated by urinaryalbumin excretion?. ### Response: For those with urine proteinZ1 g/d: target o125/75ACE-I or ARB should be the first choice oftherapy.


Instruction: What should choice of therapy and dose be titrated by?

Output: urinaryalbumin excretion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should choice of therapy and dose be titrated by?. ### Response: urinaryalbumin excretion.


Instruction: What should be used if GFRZ30 ml/min/1.73 m2?

Output: loop diuretics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be used if GFRZ30 ml/min/1.73 m2?. ### Response: loop diuretics.


Instruction: How many pages did Kidney International Supplements (2012) have?

Output: 394

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many pages did Kidney International Supplements (2012) have?. ### Response: 394.


Instruction: What was the name of the 2012 Kidney international supplement?

Output: Kidney International Supplements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the 2012 Kidney international supplement?. ### Response: Kidney International Supplements.


Instruction: What has not been a randomized trial of in patients with CeAD?

Output: antithrombotic therapy versus placebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has not been a randomized trial of in patients with CeAD?. ### Response: antithrombotic therapy versus placebo.


Instruction: What does CADISS stand for?

Output: Cervical Artery Dissection in Stroke Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CADISS stand for?. ### Response: Cervical Artery Dissection in Stroke Study.


Instruction: What group published a randomized, open-label phase II feasibility trial of anticoagulation versus antiplatelet therapy in 250 participants with extracranial carotid or vertebral artery dissection?

Output: CADISS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What group published a randomized, open-label phase II feasibility trial of anticoagulation versus antiplatelet therapy in 250 participants with extracranial carotid or vertebral artery dissection?. ### Response: CADISS.


Instruction: How many centers were recruited from the United Kingdom and Australia?

Output: 46

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many centers were recruited from the United Kingdom and Australia?. ### Response: 46.


Instruction: Where were the centers located?

Output: United Kingdom and Australia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where were the centers located?. ### Response: United Kingdom and Australia.


Instruction: What was the primary outcome of the study?

Output: ipsilateral stroke or all-cause mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary outcome of the study?. ### Response: ipsilateral stroke or all-cause mortality.


Instruction: How long after randomization did the study last?

Output: 12 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after randomization did the study last?. ### Response: 12 months.


Instruction: The primary outcome was what?

Output: ipsilateral stroke or all-cause mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The primary outcome was what?. ### Response: ipsilateral stroke or all-cause mortality.


Instruction: What was not feasible as a phase II trial?

Output: a definitive phase III trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not feasible as a phase II trial?. ### Response: a definitive phase III trial.


Instruction: Why was a definitive phase III trial not feasible?

Output: low event rates in both groups

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was a definitive phase III trial not feasible?. ### Response: low event rates in both groups.


Instruction: What percentage of cases did not have central radiological confirmation?

Output: 20%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of cases did not have central radiological confirmation?. ### Response: 20%.


Instruction: How long was the mean time to randomization?

Output: 3.65 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the mean time to randomization?. ### Response: 3.65 days.


Instruction: How much of the cases were treated with anticoagulation?

Output: 20%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the cases were treated with anticoagulation?. ### Response: 20%.


Instruction: The CADISS trial supports numerous previous studies that found no difference in what?

Output: clinical outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The CADISS trial supports numerous previous studies that found no difference in what?. ### Response: clinical outcomes.


Instruction: Anticoagulation compared with antiplatelet therapy in CeAD patients?

Output: no significant difference in clinical outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Anticoagulation compared with antiplatelet therapy in CeAD patients?. ### Response: no significant difference in clinical outcomes.


Instruction: What was no association between treatment allocation (antiplatelets versus anticoagulants) and whether DAs at baseline persisted at follow-up?

Output: whether new DAs developed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was no association between treatment allocation (antiplatelets versus anticoagulants) and whether DAs at baseline persisted at follow-up?. ### Response: whether new DAs developed.


Instruction: During how many months did the study take place?

Output: 12

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: During how many months did the study take place?. ### Response: 12.


Instruction: How many patients with DA had a stroke during 12 months of follow-up?

Output: 48

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with DA had a stroke during 12 months of follow-up?. ### Response: 48.


Instruction: How many of 216 patients without DA were stroke patients?

Output: 7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many of 216 patients without DA were stroke patients?. ### Response: 7.


Instruction: What was the age- and sex-adjusted OR of DA?

Output: 0.84

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the age- and sex-adjusted OR of DA?. ### Response: 0.84.


Instruction: A review of published studies showed what?

Output: a similarly low risk of stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A review of published studies showed what?. ### Response: a similarly low risk of stroke.


Instruction: What type of study showed a low risk of stroke in patients with DA?

Output: retrospective

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of study showed a low risk of stroke in patients with DA?. ### Response: retrospective.


Instruction: What is the prognosis of DAs?

Output: benign

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the prognosis of DAs?. ### Response: benign.


Instruction: How should DA patients be treated?

Output: medical

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How should DA patients be treated?. ### Response: medical.


Instruction: Where are Tables LI and XC in online Data Supplement 1.2?

Output: For patients with AIS and extracranial carotid or extracranial verte

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are Tables LI and XC in online Data Supplement 1.2?. ### Response: For patients with AIS and extracranial carotid or extracranial verte.


Instruction: What is extracranial EVT?

Output: stenting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is extracranial EVT?. ### Response: stenting.


Instruction: What is not well established in patients with extracranial CeAD?

Output: the value of extracranial EVT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not well established in patients with extracranial CeAD?. ### Response: the value of extracranial EVT.


Instruction: When was the IIb C-LDRecommendation revised?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the IIb C-LDRecommendation revised?. ### Response: 2014.


Instruction: There have been no controlled trials of what?

Output: antithrombotic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There have been no controlled trials of what?. ### Response: antithrombotic therapy.


Instruction: What is aureus bacteremia despite prolonged vancomycin treatment?

Output: Methicillin-resistant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is aureus bacteremia despite prolonged vancomycin treatment?. ### Response: Methicillin-resistant.


Instruction: What is the name of the study group that studied linezolid therapy for infective endocarditis?

Output: GAME Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study group that studied linezolid therapy for infective endocarditis?. ### Response: GAME Study Group.


Instruction: What did Sander A, Beiderlinden M, Schmid EN, Peters J use as rescue treatment of critically ill patients infected with methicillin-resistant staphylococci?

Output: quinupristin-dalfopristin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Sander A, Beiderlinden M, Schmid EN, Peters J use as rescue treatment of critically ill patients infected with methicillin-resistant staphylococci?. ### Response: quinupristin-dalfopristin.


Instruction: What did Nace H, Lorber B. successfully treat with telavancin?

Output: methicillin-resistant Staphylococcus aureus endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Nace H, Lorber B. successfully treat with telavancin?. ### Response: methicillin-resistant Staphylococcus aureus endocarditis.


Instruction: What is telavancin used for?

Output: Successful treatment of methicillin-resistant Staphylococcus aureus endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is telavancin used for?. ### Response: Successful treatment of methicillin-resistant Staphylococcus aureus endocarditis.


Instruction: What is the name of the drug used to treat endocarditis?

Output: telavancin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used to treat endocarditis?. ### Response: telavancin.


Instruction: When was the last version of this article published?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last version of this article published?. ### Response: April 28, 2023.


Instruction: What is the name of the reference list for Chronic Heart Failure?

Output: NICE 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the reference list for Chronic Heart Failure?. ### Response: NICE 2018.


Instruction: Subject to Notice of rights.

Output: Chronic Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Subject to Notice of rights.. ### Response: Chronic Heart Failure.


Instruction: ISBN: 978-1-4731 -3093-7 506 suspected heart failure: results of the UK natriuretic peptide study?

Output: Chronic Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ISBN: 978-1-4731 -3093-7 506 suspected heart failure: results of the UK natriuretic peptide study?. ### Response: Chronic Heart Failure.


Instruction: What is the name of the journal that studies the value of brain natriuretic peptides in primary care patients with the clinical diagnosis of chronic heart failure?

Output: Scandinavian Car diovascular Journal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies the value of brain natriuretic peptides in primary care patients with the clinical diagnosis of chronic heart failure?. ### Response: Scandinavian Car diovascular Journal.


Instruction: What journal published in 2009: 43(5):324 -9?

Output: Scandinavian Car diovascular Journal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What journal published in 2009: 43(5):324 -9?. ### Response: Scandinavian Car diovascular Journal.


Instruction: How many Hypertension events occurred in high-risk patients in June 2015?

Output: 1400

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many Hypertension events occurred in high-risk patients in June 2015?. ### Response: 1400.


Instruction: What is the name of the study that investigated hypertension in high risk patients?

Output: Heart Outcomes Prevention Evaluation Study Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated hypertension in high risk patients?. ### Response: Heart Outcomes Prevention Evaluation Study Investigators.


Instruction: In what year was the N Engl J Med published?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was the N Engl J Med published?. ### Response: 2010.


Instruction: What did the SA VE Investigators study?

Output: Effect of captopril on mortality and morbid-ity in patients with left ventricular dysfunction after myocardial infarc-tion: results of the Survival and Ventricular Enlargement trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the SA VE Investigators study?. ### Response: Effect of captopril on mortality and morbid-ity in patients with left ventricular dysfunction after myocardial infarc-tion: results of the Survival and Ventricular Enlargement trial.


Instruction: What was the effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction?

Output: Effect of captopril on mortality and morbid-ity in patients with left ventricular dysfunction after myocardial infarc-tion: results of the Survival and Ventricular Enlargement trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction?. ### Response: Effect of captopril on mortality and morbid-ity in patients with left ventricular dysfunction after myocardial infarc-tion: results of the Survival and Ventricular Enlargement trial.


Instruction: What is the SA VE Investigators trial?

Output: Survival and Ventricular Enlargement trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the SA VE Investigators trial?. ### Response: Survival and Ventricular Enlargement trial.


Instruction: What was the N Engl J Med. 1992;327:669–677?

Output: Survival and Ventricular Enlargement trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the N Engl J Med. 1992;327:669–677?. ### Response: Survival and Ventricular Enlargement trial.


Instruction: What is the EUROPA study?

Output: randomised, double-blind, placebo-controlled, multicentre trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the EUROPA study?. ### Response: randomised, double-blind, placebo-controlled, multicentre trial.


Instruction: What is TROPHY?

Output: Trial of Preventing Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is TROPHY?. ### Response: Trial of Preventing Hypertension.


Instruction: What does TROPHY stand for?

Output: Trial of Preventing Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does TROPHY stand for?. ### Response: Trial of Preventing Hypertension.


Instruction: What is the name of the study that investigated the feasibility of treating prehypertension with an angiotensin-receptor blocker?

Output: Trial of Preventing Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the feasibility of treating prehypertension with an angiotensin-receptor blocker?. ### Response: Trial of Preventing Hypertension.


Instruction: Who is the ACCORD Study Group?

Output: Cushman WC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the ACCORD Study Group?. ### Response: Cushman WC.


Instruction: What does intensive blood pressure control have on type 2 diabetes mellitus?

Output: Effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does intensive blood pressure control have on type 2 diabetes mellitus?. ### Response: Effects.


Instruction: What is the N Engl J Med. 2010:362:1575–1585?

Output: Effects of intensive blood-pressure control in type 2 diabetes mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the N Engl J Med. 2010:362:1575–1585?. ### Response: Effects of intensive blood-pressure control in type 2 diabetes mellitus.


Instruction: Kannel WB. Some lessons in cardiovascular epidemiology from where?

Output: Framingham

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Kannel WB. Some lessons in cardiovascular epidemiology from where?. ### Response: Framingham.


Instruction: What did Framingham learn from?

Output: cardiovascular epidemiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Framingham learn from?. ### Response: cardiovascular epidemiology.


Instruction: What is the acronym for Kidney Disease: Improving Global Outcomes?

Output: KDIGO

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Kidney Disease: Improving Global Outcomes?. ### Response: KDIGO.