Instruction: What are the ACCF/SCAI/STS/AATS/AHA/ASNC/HFSA/SCCT 2012 Appropriate Use Criteria for?

Output: Coronary Revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the ACCF/SCAI/STS/AATS/AHA/ASNC/HFSA/SCCT 2012 Appropriate Use Criteria for?. ### Response: Coronary Revascularization.


Instruction: What is the aim of the Criteria for Coronary Revascularization?

Output: emergency or urgent revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the aim of the Criteria for Coronary Revascularization?. ### Response: emergency or urgent revascularization.


Instruction: What are the Appropriate Use Criteria of Diagnostic Catheterization called?

Output: ACCF/SCAI/AATS/AHA/ASE/ASNC/HFSA/HRS/SCCM/SCCT/SCMR/STS 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Appropriate Use Criteria of Diagnostic Catheterization called?. ### Response: ACCF/SCAI/AATS/AHA/ASE/ASNC/HFSA/HRS/SCCM/SCCT/SCMR/STS 2012.


Instruction: What are the criteria for emergency or urgent revascularization for patients with acute coronary disease?

Output: ACCF/SCAI/STS/AATS/AHA/ASNC/HFSA/SCCT 2012 Appropriate Use Criteria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the criteria for emergency or urgent revascularization for patients with acute coronary disease?. ### Response: ACCF/SCAI/STS/AATS/AHA/ASNC/HFSA/SCCT 2012 Appropriate Use Criteria.


Instruction: What were high rates of?

Output: incomplete data col-lection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were high rates of?. ### Response: incomplete data col-lection.


Instruction: What may provide important information that will inform future clinical trials of different BP reduction strategies?

Output: nonpharmacological recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may provide important information that will inform future clinical trials of different BP reduction strategies?. ### Response: nonpharmacological recommendations.


Instruction: Several nonpharmacological recommendations for BP man-agement are relevant to both men and women?

Output: 117

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Several nonpharmacological recommendations for BP man-agement are relevant to both men and women?. ### Response: 117.


Instruction: What did a modest reduction in salt intake for 4 weeks lead to?

Output: significant and important decreases in BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a modest reduction in salt intake for 4 weeks lead to?. ### Response: significant and important decreases in BP.


Instruction: How long did salt intake lead to significant and important decreases in BP?

Output: ≥4 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did salt intake lead to significant and important decreases in BP?. ### Response: ≥4 weeks.


Instruction: What was accompanied by a small physiological increase in plasma renin activity, aldosterone, and noradrenaline?

Output: a modest reduction in salt intake

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was accompanied by a small physiological increase in plasma renin activity, aldosterone, and noradrenaline?. ### Response: a modest reduction in salt intake.


Instruction: How much salt did reductions in salt intake from 9 to 12 g/d lead to?

Output: 3 g/d

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much salt did reductions in salt intake from 9 to 12 g/d lead to?. ### Response: 3 g/d.


Instruction: What has been recommended to reduce salt intake?

Output: 9 to 12 g/d to 3 g/d

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been recommended to reduce salt intake?. ### Response: 9 to 12 g/d to 3 g/d.


Instruction: What are side effects of antihypertensive therapy encoun-tered with a higher degree of frequency in women than men?

Output: Diuretic-induced disturbances of electrolyte concentration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are side effects of antihypertensive therapy encoun-tered with a higher degree of frequency in women than men?. ### Response: Diuretic-induced disturbances of electrolyte concentration.


Instruction: What type of edema is more common in women?

Output: Diuretic-induced disturbances of electrolyte concentration are seen more frequently in women,118,119 as is angiotensin- converting enzyme inhibitor–induced cough and calcium channel blocker (CCB)–related dependent edema

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of edema is more common in women?. ### Response: Diuretic-induced disturbances of electrolyte concentration are seen more frequently in women,118,119 as is angiotensin- converting enzyme inhibitor–induced cough and calcium channel blocker (CCB)–related dependent edema.


Instruction: What is CB?

Output: calcium channel blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CB?. ### Response: calcium channel blocker.


Instruction: When was this article published?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this article published?. ### Response: April 28, 2023.


Instruction: What is a shor t explanation of wh y the committee made t he recommendation f or resear ch?

Output: see t he rationale and impact section on blood pr essur e tar gets for people wit h cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a shor t explanation of wh y the committee made t he recommendation f or resear ch?. ### Response: see t he rationale and impact section on blood pr essur e tar gets for people wit h cardiovascular disease.


Instruction: What is the rationale and impact section on blood pr essur e tar gets for people with cardiovascular disease?

Output: shor t explanation of wh y the committ ee made t he recommendation f or resear ch

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the rationale and impact section on blood pr essur e tar gets for people with cardiovascular disease?. ### Response: shor t explanation of wh y the committ ee made t he recommendation f or resear ch.


Instruction: What type of tension in adult s: diagnosis and management (NG136) NICE 2023. All right s reserved.

Output: Hyper

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of tension in adult s: diagnosis and management (NG136) NICE 2023. All right s reserved.. ### Response: Hyper.


Instruction: What is the subject t o Notice of right s?

Output: All right s reserved

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the subject t o Notice of right s?. ### Response: All right s reserved.


Instruction: When was last updat ed?

Output: 18 Mar ch 2022

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was last updat ed?. ### Response: 18 Mar ch 2022.


Instruction: What does J Am Heart Assoc. 2014;3:e001471?

Output: tions. J Am Heart Assoc. 2014;3:e001471. S7.3-21. Sawant AC, te Riele AS, Tichnell C, et al. Safety of American Heart Association-recommended minimum exercise for desmosomal mutation carriers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does J Am Heart Assoc. 2014;3:e001471?. ### Response: tions. J Am Heart Assoc. 2014;3:e001471. S7.3-21. Sawant AC, te Riele AS, Tichnell C, et al. Safety of American Heart Association-recommended minimum exercise for desmosomal mutation carriers.


Instruction: What is the safety of American Heart Association-recommended minimum exercise for desmosomal mutation carriers?

Output: S7.3-21

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the safety of American Heart Association-recommended minimum exercise for desmosomal mutation carriers?. ### Response: S7.3-21.


Instruction: How does geno-type affect clinical course in arrhythmogenic right ventricular dys-plasia/cardiomyopathy-associated diseases?

Output: Risk stratification in arrhythmogenic right ventricular dysplasia/cardiomyopathy-associ-ated desmosomal mutation carriers. Circ Arrhythm Electrophysiol. 2013;6:569–78. S7.3-24. Hershberger RE, Lindenfeld J, Mestroni L, et al. Genetic evalua-tion of cardiomyopathy–a Heart Failure Society of America practice guideline. J Card Fail. 2009;15:83–97. S7.3-25. Kapplinger JD, Landstrom AP , Salisbury BA, et al. Distinguishing arrhythmogenic right ventricular cardiomyopathy/dysplasia-associ-ated mutations from background genetic noise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does geno-type affect clinical course in arrhythmogenic right ventricular dys-plasia/cardiomyopathy-associated diseases?. ### Response: Risk stratification in arrhythmogenic right ventricular dysplasia/cardiomyopathy-associ-ated desmosomal mutation carriers. Circ Arrhythm Electrophysiol. 2013;6:569–78. S7.3-24. Hershberger RE, Lindenfeld J, Mestroni L, et al. Genetic evalua-tion of cardiomyopathy–a Heart Failure Society of America practice guideline. J Card Fail. 2009;15:83–97. S7.3-25. Kapplinger JD, Landstrom AP , Salisbury BA, et al. Distinguishing arrhythmogenic right ventricular cardiomyopathy/dysplasia-associ-ated mutations from background genetic noise.


Instruction: What is the effect of geno-type on clinical course in arrhythmogenic right ventricular dys-plasia/cardiomyopathy-associated mutation carriers?

Output: Risk stratification

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of geno-type on clinical course in arrhythmogenic right ventricular dys-plasia/cardiomyopathy-associated mutation carriers?. ### Response: Risk stratification.


Instruction: What is a risk stratification in?

Output: arrhythmogenic right ventricular dysplasia/cardiomyopathy-associ-ated desmosomal mutation carriers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk stratification in?. ### Response: arrhythmogenic right ventricular dysplasia/cardiomyopathy-associ-ated desmosomal mutation carriers.


Instruction: What does Hershberger RE, Lindenfeld J, Mestroni L, et al. do?

Output: Genetic evalua-tion of cardiomyopathy–a Heart Failure Society of America practice guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Hershberger RE, Lindenfeld J, Mestroni L, et al. do?. ### Response: Genetic evalua-tion of cardiomyopathy–a Heart Failure Society of America practice guideline.


Instruction: What is a Heart Failure Society of America practice guideline?

Output: Genetic evalua-tion of cardiomyopathy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a Heart Failure Society of America practice guideline?. ### Response: Genetic evalua-tion of cardiomyopathy.


Instruction: When did J Card Fail issue 15:83–97. S7.3-25.

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J Card Fail issue 15:83–97. S7.3-25.. ### Response: 2009.


Instruction: What did Kapplinger JD, Landstrom AP, Salisbury BA, and others do to distinguish arrhythmogenic right ventricular cardiomyopathy from background genetic noise?

Output: Distinguishing arrhythmogenic right ventricular cardiomyopathy/dysplasia-associ-ated mutations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Kapplinger JD, Landstrom AP, Salisbury BA, and others do to distinguish arrhythmogenic right ventricular cardiomyopathy from background genetic noise?. ### Response: Distinguishing arrhythmogenic right ventricular cardiomyopathy/dysplasia-associ-ated mutations.


Instruction: What predicts lifetime arrhythmic outcome and sudden cardiac death in desmosomal gene-related arrhythmogenic right ventricular cardiomyopathy?

Output: Compound and digenic heterozygosity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What predicts lifetime arrhythmic outcome and sudden cardiac death in desmosomal gene-related arrhythmogenic right ventricular cardiomyopathy?. ### Response: Compound and digenic heterozygosity.


Instruction: What are the outcomes of epicardial ablation of ventricular tachycardia in arrhythmogenic right ventricular dyspla-sia/cardiomyopathy?

Output: Epicardial substrate and out-come

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the outcomes of epicardial ablation of ventricular tachycardia in arrhythmogenic right ventricular dyspla-sia/cardiomyopathy?. ### Response: Epicardial substrate and out-come.


Instruction: What does Philips B, Madhavan S, James C, et al. believe to be the outcome of catheter ablation?

Output: Long-term efficacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Philips B, Madhavan S, James C, et al. believe to be the outcome of catheter ablation?. ### Response: Long-term efficacy.


Instruction: What type of dysplasia/cardiomyopathy can be treated with catheter ablation?

Output: arrhythmogenic right ven-tricular

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of dysplasia/cardiomyopathy can be treated with catheter ablation?. ### Response: arrhythmogenic right ven-tricular.


Instruction: When did Circ Arrhythm Electrophysiol. 2012 issue 5:499-505?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circ Arrhythm Electrophysiol. 2012 issue 5:499-505?. ### Response: 2012.


Instruction: How long did catheter abla-tion of ventricular tachycardia last?

Output: Long-term efficacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did catheter abla-tion of ventricular tachycardia last?. ### Response: Long-term efficacy.


Instruction: What year did J Am Coll Cardiol issue 50:432-40?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did J Am Coll Cardiol issue 50:432-40?. ### Response: 2007.


Instruction: What year did Am Coll Cardiol publish a 50:432–40 study?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Am Coll Cardiol publish a 50:432–40 study?. ### Response: 2007.


Instruction: What is a possible outcome of epicardial ablation of ventricular tachycardia in arrhyth-mogenic right ventricular cardiomyopathy/dysplasia?

Output: Epicardial substrate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a possible outcome of epicardial ablation of ventricular tachycardia in arrhyth-mogenic right ventricular cardiomyopathy/dysplasia?. ### Response: Epicardial substrate.


Instruction: When was Circulation published?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Circulation published?. ### Response: 2009.


Instruction: Where did Bai R, Di BL, Shivkumar K, et al. publish their findings?

Output: Circulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where did Bai R, Di BL, Shivkumar K, et al. publish their findings?. ### Response: Circulation.


Instruction: What is ventricular arrhyth-mias in arrhythmogenic right ventricular dysplasia/cardiomyopa-thy?

Output: arrhythmia-free survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ventricular arrhyth-mias in arrhythmogenic right ventricular dysplasia/cardiomyopa-thy?. ### Response: arrhythmia-free survival.


Instruction: What is arrhythmia-free survival after after endo-epicardial substrate based mapping and ablation?

Output: Ablation of ventricular arrhyth-mias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is arrhythmia-free survival after after endo-epicardial substrate based mapping and ablation?. ### Response: Ablation of ventricular arrhyth-mias.


Instruction: What technique is used to treat right ven-tricular dysplasia?

Output: scar dechanneling technique

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What technique is used to treat right ven-tricular dysplasia?. ### Response: scar dechanneling technique.


Instruction: Circ Arrhythm Electrophysiol. 2012;5:111–21. S7.3-33. What is the long-term outcome with catheter ablation of ventricular tachycardia in patients with heart failure?

Output: Combined endo-cardial and epicardial catheter ablation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circ Arrhythm Electrophysiol. 2012;5:111–21. S7.3-33. What is the long-term outcome with catheter ablation of ventricular tachycardia in patients with heart failure?. ### Response: Combined endo-cardial and epicardial catheter ablation.


Instruction: What type of salt substitutes differ from foodsrich in potassium?

Output: Potassium-containing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of salt substitutes differ from foodsrich in potassium?. ### Response: Potassium-containing.


Instruction: What may not be informative to potassium-containing salt substitute?

Output: extrapolating data from potassium intake in thediet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may not be informative to potassium-containing salt substitute?. ### Response: extrapolating data from potassium intake in thediet.


Instruction: Why is there still controversy about the risk -benefit ratio of potassium intake?

Output: more data on the safetyand ef ﬁcacy of their use in CKD become available

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is there still controversy about the risk -benefit ratio of potassium intake?. ### Response: more data on the safetyand ef ﬁcacy of their use in CKD become available.


Instruction: What may be associated with a lower risk for all-cause death, CV disease, and CV death?

Output: dietary sodium reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be associated with a lower risk for all-cause death, CV disease, and CV death?. ### Response: dietary sodium reduction.


Instruction: At advanced stages of CKD (G4 and G5), a highpotassium intake is associated with higher risk?

Output: 44–46TheWork Group suggests caution in using potassium-containingsalt substitutes in CKD populations, especially in those withadvanced CKD, hyporeninemic hypoaldosteronism, orhyperkalemia from other causes until more data on the safetyand ef ﬁcacy of their use in CKD become available (seePractice Point 2.1.2).Quality of evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: At advanced stages of CKD (G4 and G5), a highpotassium intake is associated with higher risk?. ### Response: 44–46TheWork Group suggests caution in using potassium-containingsalt substitutes in CKD populations, especially in those withadvanced CKD, hyporeninemic hypoaldosteronism, orhyperkalemia from other causes until more data on the safetyand ef ﬁcacy of their use in CKD become available (seePractice Point 2.1.2).Quality of evidence.


Instruction: TheWork Group suggests caution in using what?

Output: potassium-containingsalt substitutes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: TheWork Group suggests caution in using what?. ### Response: potassium-containingsalt substitutes.


Instruction: Who suggests caution in using potassium-containingsalt substitutes in CKD populations?

Output: TheWork Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who suggests caution in using potassium-containingsalt substitutes in CKD populations?. ### Response: TheWork Group.


Instruction: What do the Cochrane systematic reviews upda-ted?

Output: Quality of evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do the Cochrane systematic reviews upda-ted?. ### Response: Quality of evidence.


Instruction: What did the Cochrane systematic reviews upda-ted for this guideline find low-to-moderate-quality evidence showing?

Output: dietary sodium reduction results in short-term reductions in BP in CKD populations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Cochrane systematic reviews upda-ted for this guideline find low-to-moderate-quality evidence showing?. ### Response: dietary sodium reduction results in short-term reductions in BP in CKD populations.


Instruction: What does dietary sodium reduction result in?

Output: short-term reductions in BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does dietary sodium reduction result in?. ### Response: short-term reductions in BP.


Instruction: What type of diabetes is low in Supplementary Tables S659-63?

Output: Type 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diabetes is low in Supplementary Tables S659-63?. ### Response: Type 1.


Instruction: What is high in Supplemental Table S764-69 in Type 1 diabetes?

Output: BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is high in Supplemental Table S764-69 in Type 1 diabetes?. ### Response: BP.


Instruction: In addition to CKD and diabetes, what other type of diabetic condition is low?

Output: albuminuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In addition to CKD and diabetes, what other type of diabetic condition is low?. ### Response: albuminuria.


Instruction: What is evidence confirming in SBP and DBP reduction in the general population?

Output: short-term bene ﬁts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is evidence confirming in SBP and DBP reduction in the general population?. ### Response: short-term bene ﬁts.


Instruction: What may be greater in persons with highBP which is more prevalent in CKD patients?

Output: BP lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be greater in persons with highBP which is more prevalent in CKD patients?. ### Response: BP lowering.


Instruction: There is moderate strength of evidence from what?

Output: sys-tematic reviews

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is moderate strength of evidence from what?. ### Response: sys-tematic reviews.


Instruction: What reduces CVdisease in the general population?

Output: lowering of sodium intake

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What reduces CVdisease in the general population?. ### Response: lowering of sodium intake.


Instruction: What was kidney failure formerly known as?

Output: end-stage kidneydisease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was kidney failure formerly known as?. ### Response: end-stage kidneydisease.


Instruction: What does ESKD stand for?

Output: end-stage kidneydisease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ESKD stand for?. ### Response: end-stage kidneydisease.


Instruction: What does the Work Group agree there is no reason to believe that the epidemiologic findings would be different in CKD populations?

Output: gen-eral population

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Work Group agree there is no reason to believe that the epidemiologic findings would be different in CKD populations?. ### Response: gen-eral population.


Instruction: What does GDMT stand for?

Output: optimal medical therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does GDMT stand for?. ### Response: optimal medical therapy.


Instruction: What is the primary class of therapy defined by the ACCF/AHA guideline-recommended therapies?

Output: Class I

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary class of therapy defined by the ACCF/AHA guideline-recommended therapies?. ### Response: Class I.


Instruction: Which new term will be used throughout sub-sequent guidelines?

Output: GDMT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which new term will be used throughout sub-sequent guidelines?. ### Response: GDMT.


Instruction: Why do ACCF and AHA practice guidelines address patient populations?

Output: residing in North America

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why do ACCF and AHA practice guidelines address patient populations?. ### Response: residing in North America.


Instruction: What is discussed in the text without a specific COR?

Output: drugs that are not currently available in North America

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is discussed in the text without a specific COR?. ### Response: drugs that are not currently available in North America.


Instruction: What does each writing committee review for studies performed in large numbers of subjects outside North America?

Output: the potential influ-ence of different practice patterns and patient populations on the treatment effect and relevance to the ACCF/AHA target population

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does each writing committee review for studies performed in large numbers of subjects outside North America?. ### Response: the potential influ-ence of different practice patterns and patient populations on the treatment effect and relevance to the ACCF/AHA target population.


Instruction: What are the ACCF/AHA practice guidelines intended to assist healthcare providers in?

Output: clinical decision making

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the ACCF/AHA practice guidelines intended to assist healthcare providers in?. ### Response: clinical decision making.


Instruction: What do guidelines attempt to define that meet the needs of most patients in most circumstances?

Output: practices

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do guidelines attempt to define that meet the needs of most patients in most circumstances?. ### Response: practices.


Instruction: Who must make the final judgment regarding care of a particular patient?

Output: the healthcare provider and patient

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who must make the final judgment regarding care of a particular patient?. ### Response: the healthcare provider and patient.


Instruction: What must be made by the healthcare provider and patient in light of all the circumstances presented by that patient?

Output: The ultimate judgment regarding care of a particular patient

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must be made by the healthcare provider and patient in light of all the circumstances presented by that patient?. ### Response: The ultimate judgment regarding care of a particular patient.


Instruction: What may arise for which deviations from these guidelines may be appropriate?

Output: situ-ations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may arise for which deviations from these guidelines may be appropriate?. ### Response: situ-ations.


Instruction: What should clinical decision making involve consideration of?

Output: quality and availability of expertise in the area where care is provided

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should clinical decision making involve consideration of?. ### Response: quality and availability of expertise in the area where care is provided.


Instruction: What should the goal be when guidelines are used as a basis for regulatory or payer decisions?

Output: improvement in quality of care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should the goal be when guidelines are used as a basis for regulatory or payer decisions?. ### Response: improvement in quality of care.


Instruction: What does the Task Force recognize that situations arise in which additional data are needed to inform patient care more effectively?

Output: these areas are identified within each respective guideline when appropriate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Task Force recognize that situations arise in which additional data are needed to inform patient care more effectively?. ### Response: these areas are identified within each respective guideline when appropriate.


Instruction: What is effective only if prescribed courses of treatment are followed?

Output: Prescribed courses of treatment in accordance with these recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is effective only if prescribed courses of treatment are followed?. ### Response: Prescribed courses of treatment in accordance with these recommendations.


Instruction: What is effective only if followed?

Output: Prescribed courses of treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is effective only if followed?. ### Response: Prescribed courses of treatment.


Instruction: Lack of patient understanding and adherence may adversely affect what?

Output: outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Lack of patient understanding and adherence may adversely affect what?. ### Response: outcomes.


Instruction: What should physicians and other healthcare providers make every effort to engage the patient in?

Output: prescribed medical regimens and lifestyles

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should physicians and other healthcare providers make every effort to engage the patient in?. ### Response: prescribed medical regimens and lifestyles.


Instruction: Patients should be informed of the risks, benefits, and what else?

Output: alterna-tives

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients should be informed of the risks, benefits, and what else?. ### Response: alterna-tives.


Instruction: What is the benefit-to-risk ratio for COR IIa and IIb?

Output: lower

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the benefit-to-risk ratio for COR IIa and IIb?. ### Response: lower.


Instruction: The Task Force makes every effort to avoid what?

Output: actual

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The Task Force makes every effort to avoid what?. ### Response: actual.


Instruction: What was the adjusted hazard ratio of sponta-neous pregnancy loss in the statin-exposed women versus controls?

Output: increased

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the adjusted hazard ratio of sponta-neous pregnancy loss in the statin-exposed women versus controls?. ### Response: increased.


Instruction: What was used as a covariant in a recent retrospective cohort study?

Output: time-to-event analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was used as a covariant in a recent retrospective cohort study?. ### Response: time-to-event analysis.


Instruction: What was the adjusted hazard ratio of sponta-neous pregnancy loss in the statin-exposed group increased?

Output: S4.5.3-12

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the adjusted hazard ratio of sponta-neous pregnancy loss in the statin-exposed group increased?. ### Response: S4.5.3-12.


Instruction: What may be related to older age, CVD risk factors, and other medications?

Output: The increase in miscarriages

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be related to older age, CVD risk factors, and other medications?. ### Response: The increase in miscarriages.


Instruction: A reasonable approach is to stop statins 1 to what month before pregnancy is attempted?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A reasonable approach is to stop statins 1 to what month before pregnancy is attempted?. ### Response: 2.


Instruction: How long before pregnancy is attempted?

Output: 1 to 2 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long before pregnancy is attempted?. ### Response: 1 to 2 months.


Instruction: What should be stopped promptly and not restarted until after pregnancy and breastfeeding are completed?

Output: statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be stopped promptly and not restarted until after pregnancy and breastfeeding are completed?. ### Response: statin therapy.


Instruction: Cholesterol levels rise in pregnancy, with a similar percentage rise in normal women and those with what?

Output: heterozygous

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cholesterol levels rise in pregnancy, with a similar percentage rise in normal women and those with what?. ### Response: heterozygous.


Instruction: Who should be consulted for women with FH?

Output: An experienced lipid specialist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should be consulted for women with FH?. ### Response: An experienced lipid specialist.


Instruction: What does FH not appear to have a higher risk of?

Output: preterm delivery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does FH not appear to have a higher risk of?. ### Response: preterm delivery.


Instruction: What should be consulted for women with homozygous FH?

Output: An experienced lipid specialist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be consulted for women with homozygous FH?. ### Response: An experienced lipid specialist.


Instruction: What does triglyceride levels rise with each trimester?

Output: progressively

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does triglyceride levels rise with each trimester?. ### Response: progressively.


Instruction: How can women with a trichloride level 500 mg/dL at the onset of pregnancy develop?

Output: severe hypertriglyceridemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can women with a trichloride level 500 mg/dL at the onset of pregnancy develop?. ### Response: severe hypertriglyceridemia.


Instruction: What can hypertriglyceridemia lead to during the third trimester of pregnancy?

Output: pancreatitis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can hypertriglyceridemia lead to during the third trimester of pregnancy?. ### Response: pancreatitis.


Instruction: What can lead to pancreatitis?

Output: severe hypertriglyceridemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can lead to pancreatitis?. ### Response: severe hypertriglyceridemia.


Instruction: Advising patients on lifestyle, including both diet and physical activity, can reduce what?

Output: levels of triglycerides

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Advising patients on lifestyle, including both diet and physical activity, can reduce what?. ### Response: levels of triglycerides.


Instruction: What can medications that are less likely to raise tri-glycerides reduce before pregnancy begins?

Output: levels of triglycerides

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can medications that are less likely to raise tri-glycerides reduce before pregnancy begins?. ### Response: levels of triglycerides.


Instruction: What is beyond the scope of the present guideline and requires consultation with an experienced lipid specialist?

Output: Treatment of severe hypertri-glyceridemic pregnancy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is beyond the scope of the present guideline and requires consultation with an experienced lipid specialist?. ### Response: Treatment of severe hypertri-glyceridemic pregnancy.


Instruction: Adults With CKDReferenced studies that support recommendations are what?

Output: Online Data Supplements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Adults With CKDReferenced studies that support recommendations are what?. ### Response: Online Data Supplements.


Instruction: What are CKDRecommendations for Adults summarized in?

Output: Online Data Supplements 36 to 38

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are CKDRecommendations for Adults summarized in?. ### Response: Online Data Supplements 36 to 38.


Instruction: How old are adults 40 to 75 years of age with LDL-C 70 to 189 mg/dL?

Output: 10-year ASCVD risk of 7.5% or higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old are adults 40 to 75 years of age with LDL-C 70 to 189 mg/dL?. ### Response: 10-year ASCVD risk of 7.5% or higher.


Instruction: What is the 10-year ASCVD risk of 7.5% or higher?

Output: 40 to 75 years of age with LDL-C 70 to 189 mg/dL (1.7 to 4.8 mmol/L)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 10-year ASCVD risk of 7.5% or higher?. ### Response: 40 to 75 years of age with LDL-C 70 to 189 mg/dL (1.7 to 4.8 mmol/L).


Instruction: CKD not treated with dialysis or kidney transplantation is a risk-enhancing factor.

Output: 40 to 75 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: CKD not treated with dialysis or kidney transplantation is a risk-enhancing factor.. ### Response: 40 to 75 years of age.


Instruction: What can be useful?

Output: initiation of a moderate-intensity statin or moderate-intensity statins combined with ezetimibe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be useful?. ### Response: initiation of a moderate-intensity statin or moderate-intensity statins combined with ezetimibe.


Instruction: What is a risk-enhancing factor for kidney disease?

Output: CKD not treated with dialysis or kidney transplantation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk-enhancing factor for kidney disease?. ### Response: CKD not treated with dialysis or kidney transplantation.


Instruction: In adults with advanced kidney disease who require dialysis treatment, initiation of a statin is not recommended?

Output: S4.5.4-2III: No BenefitB-R3.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In adults with advanced kidney disease who require dialysis treatment, initiation of a statin is not recommended?. ### Response: S4.5.4-2III: No BenefitB-R3..


Instruction: What is not recommended of a statin?

Output: In adults with advanced kidney disease who require dialysis treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended of a statin?. ### Response: In adults with advanced kidney disease who require dialysis treatment.


Instruction: What is a risk-enhancing factor for ASCVD?

Output: CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk-enhancing factor for ASCVD?. ### Response: CKD.


Instruction: What is the acronym for Committee on Standards for Developing Trustworthy Clinical Practice Guidelines?

Output: Task Force on Clinical Practice Guide-lines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Committee on Standards for Developing Trustworthy Clinical Practice Guidelines?. ### Response: Task Force on Clinical Practice Guide-lines.


Instruction: When was the document ucm_319826.pdf downloadable?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the document ucm_319826.pdf downloadable?. ### Response: 2010.


Instruction: What is the Committee on Standards for Systematic Reviews of Comparative Effectiveness Research, Institute of Medicine (US) responsible for?

Output: Developing Trustworthy Clinical Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Committee on Standards for Systematic Reviews of Comparative Effectiveness Research, Institute of Medicine (US) responsible for?. ### Response: Developing Trustworthy Clinical Practice Guidelines.


Instruction: Where is National Academies Press located?

Output: Washington, DC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is National Academies Press located?. ### Response: Washington, DC.


Instruction: What is the name of the summit report on the ACCF/AHA clinical prac-tice guideline methodology?

Output: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the summit report on the ACCF/AHA clinical prac-tice guideline methodology?. ### Response: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.


Instruction: What are the names of the members of the Task Force on Practice Guidelines?

Output: Jacobs AK, Anderson JL, Halperin JL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the members of the Task Force on Practice Guidelines?. ### Response: Jacobs AK, Anderson JL, Halperin JL.


Instruction: When was the Circulation 127:268–310?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circulation 127:268–310?. ### Response: 2013.


Instruction: What is the name of the Task Force on Practice Guidelines?

Output: American College of Cardiology Foundation/American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Practice Guidelines?. ### Response: American College of Cardiology Foundation/American Heart Association.


Instruction: How long did it take for ACC/AHA clinical practice guidelines to evolve?

Output: 30-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for ACC/AHA clinical practice guidelines to evolve?. ### Response: 30-year.


Instruction: What year did Circulation issue 130:1208-17?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Circulation issue 130:1208-17?. ### Response: 2014.


Instruction: What is the name of the Task Force on Perfor-mance Measures and Practice Guidelines?

Output: American College of Cardiology/American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Perfor-mance Measures and Practice Guidelines?. ### Response: American College of Cardiology/American Heart Association.


Instruction: What is Arnett DK, Goodman RA, Halperin JL, et al.?

Output: AHA/ACC/HHS strate-gies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Arnett DK, Goodman RA, Halperin JL, et al.?. ### Response: AHA/ACC/HHS strate-gies.


Instruction: The American College of Cardiology and the U.S. Department of Health and Human Services are among what organizations?

Output: Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The American College of Cardiology and the U.S. Department of Health and Human Services are among what organizations?. ### Response: Heart Association.


Instruction: Circulation. 2014;130:1662–7. What is Halperin JL, Levine GN, Al-Khatib SM, et al?

Output: 8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation. 2014;130:1662–7. What is Halperin JL, Levine GN, Al-Khatib SM, et al?. ### Response: 8.


Instruction: What did the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines recommend?

Output: Perfor-mance Measures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines recommend?. ### Response: Perfor-mance Measures.


Instruction: What is the name of the study that examined the effects of enalapril on mortality in severe congestive heart failure?

Output: Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined the effects of enalapril on mortality in severe congestive heart failure?. ### Response: Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS).


Instruction: What does CONSENSUS stand for?

Output: North Scandinavian Enalapril Survival Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CONSENSUS stand for?. ### Response: North Scandinavian Enalapril Survival Study.


Instruction: What is the name of the study that studied the effects of enalapril on patients with reduced left ven-tricular ejection fractions and congestive heart failure?

Output: North Scandinavian Enalapril Survival Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that studied the effects of enalapril on patients with reduced left ven-tricular ejection fractions and congestive heart failure?. ### Response: North Scandinavian Enalapril Survival Study.


Instruction: What is lisinopril an angiotensin-converting enzyme inhibitor?

Output: low and high doses of the angiotensin-converting enzyme inhibitor, lisinopril, on morbidity and mortality in chronic heart fail-ure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is lisinopril an angiotensin-converting enzyme inhibitor?. ### Response: low and high doses of the angiotensin-converting enzyme inhibitor, lisinopril, on morbidity and mortality in chronic heart fail-ure.


Instruction: What is the ATLAS Study?

Output: ATLAS Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ATLAS Study?. ### Response: ATLAS Study Group.


Instruction: What is the name of the study group that studies heart failure?

Output: ATLAS Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study group that studies heart failure?. ### Response: ATLAS Study Group.


Instruction: When was Circulation published?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Circulation published?. ### Response: 1999.


Instruction: Chronic Heart Failure Treating Heart Failure  NICE 2018. All rights reserved. Subject to What?

Output: Notice of rights

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Chronic Heart Failure Treating Heart Failure  NICE 2018. All rights reserved. Subject to What?. ### Response: Notice of rights.


Instruction: ISBN: 978-1-4731 -3093 -7139 6.2.3.4 Economic evidence Published literature No relevant health economic studies were identified.

Output: Chronic Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ISBN: 978-1-4731 -3093 -7139 6.2.3.4 Economic evidence Published literature No relevant health economic studies were identified.. ### Response: Chronic Heart Failure.


Instruction: Where are unit costs presented in absence of any economic analysis?

Output: Table 43 below

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are unit costs presented in absence of any economic analysis?. ### Response: Table 43 below.


Instruction: What are likely to be incurred in the first year of initiation due to up -titration?

Output: Additional costs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are likely to be incurred in the first year of initiation due to up -titration?. ### Response: Additional costs.


Instruction: What are the costs of Mineralcorticoid receptor antagonists presented in?

Output: Table 44

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the costs of Mineralcorticoid receptor antagonists presented in?. ### Response: Table 44.


Instruction: What is the cost of Spironolactone 25 1 28 1.40 0.05 18 50 1 28 3.16

Output: Cost/year (£)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cost of Spironolactone 25 1 28 1.40 0.05 18 50 1 28 3.16. ### Response: Cost/year (£).


Instruction: How much does Eplerenone cost?

Output: 25 1 28 3.99

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much does Eplerenone cost?. ### Response: 25 1 28 3.99.


Instruction: What is the name of the drug that is being sold in the UK?

Output: Spironolactone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug that is being sold in the UK?. ### Response: Spironolactone.


Instruction: When was the NHS Drug Tariff published?

Output: May

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the NHS Drug Tariff published?. ### Response: May.


Instruction: Table 44: Unit costs of up - titration What is the unit cost of a nurse specialist appointment in community setting?

Output: £91 per hour

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Table 44: Unit costs of up - titration What is the unit cost of a nurse specialist appointment in community setting?. ### Response: £91 per hour.


Instruction: How much does the NHS Reference costs 2014/15242?

Output: £3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much does the NHS Reference costs 2014/15242?. ### Response: £3.


Instruction: What does a 30 minute appointment occur every 30 minutes?

Output: maximum tolerated dose achieved

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does a 30 minute appointment occur every 30 minutes?. ### Response: maximum tolerated dose achieved.


Instruction: Who agreed that the cost of all cause hospitalisation and acute kidney injury should be included in the NHS Reference costs 2014/15242?

Output: The GC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who agreed that the cost of all cause hospitalisation and acute kidney injury should be included in the NHS Reference costs 2014/15242?. ### Response: The GC.


Instruction: How many appointments are scheduled every 4 weeks until maximum tolerated dose is achieved?

Output: 30 minute

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many appointments are scheduled every 4 weeks until maximum tolerated dose is achieved?. ### Response: 30 minute.


Instruction: What is the name of the direct access service?

Output: community

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the direct access service?. ### Response: community.


Instruction: What did the GC agree would be typical for a chronic heart failure population experiencing hyperkalaemia or worsening renal function?

Output: the cost of acute kidney injury t reatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the GC agree would be typical for a chronic heart failure population experiencing hyperkalaemia or worsening renal function?. ### Response: the cost of acute kidney injury t reatment.


Instruction: What is the Unit cost Source All-cause hospitalisation?

Output: £2,930

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Unit cost Source All-cause hospitalisation?. ### Response: £2,930.


Instruction: How much is the NHS Reference costs 2014/15242 Acute kidney injury (with and without interventions)?

Output: £2,337

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much is the NHS Reference costs 2014/15242 Acute kidney injury (with and without interventions)?. ### Response: £2,337.


Instruction: What does LA07H -P cost?

Output: £2,337

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does LA07H -P cost?. ### Response: £2,337.


Instruction: How many publications reported clinical two studies comparing MRAs with placebo in people with heart failure with preserved ejection fraction on current standard first line treatment?

Output: 11

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many publications reported clinical two studies comparing MRAs with placebo in people with heart failure with preserved ejection fraction on current standard first line treatment?. ### Response: 11.


Instruction: What was included in the review of spironolactone and placebo?

Output: Two studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was included in the review of spironolactone and placebo?. ### Response: Two studies.


Instruction: What was the quality of the evidence in both studies?

Output: high to very low

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the quality of the evidence in both studies?. ### Response: high to very low.


Instruction: Why was the evidence downgraded?

Output: due to a number of contributory factors including r isk of bias, imprecision due to wide confidence intervals surrounding the effect estimate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the evidence downgraded?. ### Response: due to a number of contributory factors including r isk of bias, imprecision due to wide confidence intervals surrounding the effect estimate.


Instruction: What are some contributory factors?

Output: r isk of bias, imprecision due to wide confidence intervals surrounding the effect estimate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some contributory factors?. ### Response: r isk of bias, imprecision due to wide confidence intervals surrounding the effect estimate.


Instruction: What is imprecision due to wide confidence intervals surrounding the effect estimate?

Output: r isk of bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is imprecision due to wide confidence intervals surrounding the effect estimate?. ### Response: r isk of bias.


Instruction: What is especially common with inferior NSTEMI?

Output: Sinus bradycardia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is especially common with inferior NSTEMI?. ### Response: Sinus bradycardia.


Instruction: What should be treated with atropine and, if not responsive, temporary pacing?

Output: Symptomatic or hemodynamically significant sinus bradycardia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be treated with atropine and, if not responsive, temporary pacing?. ### Response: Symptomatic or hemodynamically significant sinus bradycardia.


Instruction: The incidence of complete heart block is 1.0% to 3.7% in what?

Output: NSTEMI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The incidence of complete heart block is 1.0% to 3.7% in what?. ### Response: NSTEMI.


Instruction: What percentage of NSTEMI is based on anterior or posterior/inferior location?

Output: 1.0% to 3.7%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of NSTEMI is based on anterior or posterior/inferior location?. ### Response: 1.0% to 3.7%.


Instruction: How many patients develop atrioventricular block and bun-dle-branch block?

Output: 5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients develop atrioventricular block and bun-dle-branch block?. ### Response: 5%.


Instruction: What is more ominous because of a greater extent of myocardial injury and involvement of the conduction system?

Output: High-degree atrioventricular block

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more ominous because of a greater extent of myocardial injury and involvement of the conduction system?. ### Response: High-degree atrioventricular block.


Instruction: What does not require treatment for first degree atrioventricular block?

Output: 587

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not require treatment for first degree atrioventricular block?. ### Response: 587.


Instruction: What is the most common type of high-grade ventricular block after inferior NSTEMI?

Output: transient

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common type of high-grade ventricular block after inferior NSTEMI?. ### Response: transient.


Instruction: How can a junctional escape rhythm be managed?

Output: with an ischemia-guided strategy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can a junctional escape rhythm be managed?. ### Response: with an ischemia-guided strategy.


Instruction: What type of pacemaker is recommended for high-grade atrioven-tricular block, new bundle-branch block, or bifascicular block with anterior infarction?

Output: tem-porary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of pacemaker is recommended for high-grade atrioven-tricular block, new bundle-branch block, or bifascicular block with anterior infarction?. ### Response: tem-porary.


Instruction: What is the 2012 device-based therapy CPG.207.2.2?

Output: Indications for permanent pacing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2012 device-based therapy CPG.207.2.2?. ### Response: Indications for permanent pacing.


Instruction: Why is early revascularization recommended in suitable patients?

Output: cardiac pump failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is early revascularization recommended in suitable patients?. ### Response: cardiac pump failure.


Instruction: What is the leading cause of cardiogenic shock?

Output: AMI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the leading cause of cardiogenic shock?. ### Response: AMI.


Instruction: Why is early revascularization a mainstay in the treatment?

Output: AMI is the leading cause of cardiogenic shock

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is early revascularization a mainstay in the treatment?. ### Response: AMI is the leading cause of cardiogenic shock.


Instruction: What is compared with medical therapy?

Output: early revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is compared with medical therapy?. ### Response: early revascularization.


Instruction: Early revascularization is asso-ciated with what?

Output: improved 6-month mortality560 and 13% absolute mortality reduction at 6 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Early revascularization is asso-ciated with what?. ### Response: improved 6-month mortality560 and 13% absolute mortality reduction at 6 years.


Instruction: What is an improvement in 6-month mortality560 and 13% absolute mortality reduction at 6 years?

Output: early revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an improvement in 6-month mortality560 and 13% absolute mortality reduction at 6 years?. ### Response: early revascularization.


Instruction: Urgent re-vascularization with CABG may be indicated for failed PCI, what type of anatomy not amenable to PCI and at the time of surgical repair?

Output: coronary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Urgent re-vascularization with CABG may be indicated for failed PCI, what type of anatomy not amenable to PCI and at the time of surgical repair?. ### Response: coronary.


Instruction: What is an example of a mechani-cal defect?

Output: septal, papillary muscle, free-wall rupture

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a mechani-cal defect?. ### Response: septal, papillary muscle, free-wall rupture.


Instruction: What is not a contraindication to urgent revascularization for cardiogenic shock?

Output: Age alone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not a contraindication to urgent revascularization for cardiogenic shock?. ### Response: Age alone.


Instruction: Mortality has steadily improved after what?

Output: cardiogenic shock

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Mortality has steadily improved after what?. ### Response: cardiogenic shock.


Instruction: How long has mortality ranging from approximately 40% with milder forms of shock268 to >45% with refractory shock592?

Output: 30-day

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long has mortality ranging from approximately 40% with milder forms of shock268 to >45% with refractory shock592?. ### Response: 30-day.


Instruction: What percentage of patients with milder forms of shock have refractory shock?

Output: >45%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients with milder forms of shock have refractory shock?. ### Response: >45%.


Instruction: What percent of patients in the IABP-SHOCK II trial presented with NSTEMI?

Output: 30%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percent of patients in the IABP-SHOCK II trial presented with NSTEMI?. ### Response: 30%.


Instruction: What did the Randomized International Study in Unstable Acute Myocardial Infarction Patients With Cardiogenic Shock) trial have on presentation?

Output: ST depres-sion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Randomized International Study in Unstable Acute Myocardial Infarction Patients With Cardiogenic Shock) trial have on presentation?. ### Response: ST depres-sion.


Instruction: What percentage of patients with ACS who had NSTEMI in the GRACE registry experi-enced cardiogenic shock?

Output: 4.6%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients with ACS who had NSTEMI in the GRACE registry experi-enced cardiogenic shock?. ### Response: 4.6%.


Instruction: Of the 2992 patients in shock, what percentage underwent cardiac catheterization?

Output: 57%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Of the 2992 patients in shock, what percentage underwent cardiac catheterization?. ### Response: 57%.


Instruction: How many patients in shock underwent cardiac catheterization?

Output: 57%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients in shock underwent cardiac catheterization?. ### Response: 57%.


Instruction: What percentage of shock patients underwent in-hospital revasculariza-tion?

Output: 47%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of shock patients underwent in-hospital revasculariza-tion?. ### Response: 47%.


Instruction: In-hospital mortality of all patients with shock was what?

Output: 59%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In-hospital mortality of all patients with shock was what?. ### Response: 59%..


Instruction: What is the US Preventive Services Task Force reaffirmation recommenda-tion statement?

Output: Counseling, and interventions to prevent tobacco use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the US Preventive Services Task Force reaffirmation recommenda-tion statement?. ### Response: Counseling, and interventions to prevent tobacco use.


Instruction: What is a comparison of high-dose and low-dose drugs?

Output: nicotine replacement therapy, varenicline, and bupropion for smoking cessation: a systematic review and multiple treatment meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a comparison of high-dose and low-dose drugs?. ### Response: nicotine replacement therapy, varenicline, and bupropion for smoking cessation: a systematic review and multiple treatment meta-analysis.


Instruction: What is a combination of varenicline and bupropion for smoking cessation?

Output: nicotine replacement therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a combination of varenicline and bupropion for smoking cessation?. ### Response: nicotine replacement therapy.


Instruction: What is the name of the systematic review and multiple treatment meta-analysis that compares high-dose and combination nicotine replacement therapy?

Output: varenicline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and multiple treatment meta-analysis that compares high-dose and combination nicotine replacement therapy?. ### Response: varenicline.


Instruction: What is rehabilitation in chronic heart failure?

Output: All rights reserved

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is rehabilitation in chronic heart failure?. ### Response: All rights reserved.


Instruction: What is NICE 2018 Subject to?

Output: Notice of rights

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE 2018 Subject to?. ### Response: Notice of rights.


Instruction: Who is subject to Notice of rights?

Output: Rehabilitation in chro nic heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is subject to Notice of rights?. ### Response: Rehabilitation in chro nic heart failure.


Instruction: What are the limitations of a study?

Output: Very serious limitations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the limitations of a study?. ### Response: Very serious limitations.


Instruction: What is the effect of the study on the cost effectiveness?

Output: Incremental effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of the study on the cost effectiveness?. ### Response: Incremental effects.


Instruction: How serious are these limitations?

Output: Very serious

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How serious are these limitations?. ### Response: Very serious.


Instruction: What is ICER?

Output: incremental cost -effectiveness ratio

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ICER?. ### Response: incremental cost -effectiveness ratio.


Instruction: How long does it take for people with heart failure to be clinically stable?

Output: one month

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take for people with heart failure to be clinically stable?. ### Response: one month.


Instruction: What is the average follow-up for 5 years?

Output: £480

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the average follow-up for 5 years?. ### Response: £480.


Instruction: What does ICER stand for?

Output: incremental cost -effectiveness ratio

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ICER stand for?. ### Response: incremental cost -effectiveness ratio.


Instruction: What is the abbreviation for QALY?

Output: quality -adjusted life years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the abbreviation for QALY?. ### Response: quality -adjusted life years.


Instruction: Does not include any health outcomes?

Output: (a)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Does not include any health outcomes?. ### Response: (a).


Instruction: What is the baseline patient charact eristics not typical with a very high proportion of males?

Output: Small sample size, which has significant impact on cost per patient for the home training group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the baseline patient charact eristics not typical with a very high proportion of males?. ### Response: Small sample size, which has significant impact on cost per patient for the home training group.


Instruction: The usual care group nearly 10 years younger than what group?

Output: hospi tal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The usual care group nearly 10 years younger than what group?. ### Response: hospi tal.


Instruction: No discounting was undertaken.

Output: the usual care group nearly 10 years younger than hospi tal group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No discounting was undertaken.. ### Response: the usual care group nearly 10 years younger than hospi tal group.


Instruction: What was an additional comparator of usual care included in the study?

Output: Hospital training

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was an additional comparator of usual care included in the study?. ### Response: Hospital training.


Instruction: What were both hospital training and home training cost sav ing compared to?

Output: usual care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were both hospital training and home training cost sav ing compared to?. ### Response: usual care.


Instruction: What was the annual risk of the kidney and cardio-vascular end points all approached?

Output: 10%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the annual risk of the kidney and cardio-vascular end points all approached?. ### Response: 10%..


Instruction: How many RCTs have provided high-quality evidence in type 1 diabetes?

Output: Several

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs have provided high-quality evidence in type 1 diabetes?. ### Response: Several.


Instruction: What does ACE-Is reduce the risk of?

Output: kidney outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ACE-Is reduce the risk of?. ### Response: kidney outcomes.


Instruction: Why has no clear effect on cardiovascular out-comes been established?

Output: inadequatepower

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why has no clear effect on cardiovascular out-comes been established?. ### Response: inadequatepower.


Instruction: What is the applicability of study findings to the entire CKD and diabetes population?

Output: limited

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the applicability of study findings to the entire CKD and diabetes population?. ### Response: limited.


Instruction: Why is the entire CKD anddiabetes population limited?

Output: majorstudies have excluded patients with clinically signiﬁcantCVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is the entire CKD anddiabetes population limited?. ### Response: majorstudies have excluded patients with clinically signiﬁcantCVD.


Instruction: Why have majorstudies excluded patients with clinically significantCVD?

Output: applicability of study ﬁndings to the entire CKD anddiabetes population is somewhat limited

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why have majorstudies excluded patients with clinically significantCVD?. ### Response: applicability of study ﬁndings to the entire CKD anddiabetes population is somewhat limited.


Instruction: There is high-quality evidence from trials of high-riskindividuals from what?

Output: the general population

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is high-quality evidence from trials of high-riskindividuals from what?. ### Response: the general population.


Instruction: What did the studies not focus on?

Output: patients with clinically signiﬁcantalbuminuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the studies not focus on?. ### Response: patients with clinically signiﬁcantalbuminuria.


Instruction: What was not a benefit of ACE-Is as compared to diuretic therapy in the CKD and diabeticsubgroups?

Output: ALLHAT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not a benefit of ACE-Is as compared to diuretic therapy in the CKD and diabeticsubgroups?. ### Response: ALLHAT.


Instruction: What was the difference in BP between diuretictherapy and ACE-Is?

Output: clear BP differences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the difference in BP between diuretictherapy and ACE-Is?. ### Response: clear BP differences.


Instruction: Why was the comparison between the two groups difficult?

Output: majorstudies have excluded patients with clinically signiﬁcantCVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the comparison between the two groups difficult?. ### Response: majorstudies have excluded patients with clinically signiﬁcantCVD.


Instruction: What is the level of evidence in this study?

Output: high

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the level of evidence in this study?. ### Response: high.


Instruction: Who made the decision on the grade of this recommendation statement?

Output: a majority vote

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who made the decision on the grade of this recommendation statement?. ### Response: a majority vote.


Instruction: What percentage of Work Group members supported an evidence grade of A?

Output: The minority

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of Work Group members supported an evidence grade of A?. ### Response: The minority.


Instruction: The choice between an ACE-I and an ARB in CKDpatients is what?

Output: controversial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The choice between an ACE-I and an ARB in CKDpatients is what?. ### Response: controversial.


Instruction: What is older and applies mostly to type 1 diabetes?

Output: the evidence for kidneyoutcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is older and applies mostly to type 1 diabetes?. ### Response: the evidence for kidneyoutcomes.


Instruction: The evidence supporting the use of ARB comes from more recent trials in what type ofdiabetes?

Output: diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The evidence supporting the use of ARB comes from more recent trials in what type ofdiabetes?. ### Response: diabetes.


Instruction: For cardiovascular protection in patients with diabetes, what largely points to ACE-Is?

Output: the evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For cardiovascular protection in patients with diabetes, what largely points to ACE-Is?. ### Response: the evidence.


Instruction: What do the availabledata suggest the effects of both classes of agents are likely to be?

Output: similar

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do the availabledata suggest the effects of both classes of agents are likely to be?. ### Response: similar.


Instruction: Cost and availability may be animportant consideration in some countries.

Output: agents are likely to be similar

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cost and availability may be animportant consideration in some countries.. ### Response: agents are likely to be similar.


Instruction: Within-class effects on hard outcomes may differ and depend on what?

Output: the dose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Within-class effects on hard outcomes may differ and depend on what?. ### Response: the dose.


Instruction: What may depend on the dose?

Output: within-class effects on hard outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may depend on the dose?. ### Response: within-class effects on hard outcomes.


Instruction: A 2004meta-analysis concluded that there was insufficient evidenceon the relative effects of ACE-Is versus ARBs on what?

Output: survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A 2004meta-analysis concluded that there was insufficient evidenceon the relative effects of ACE-Is versus ARBs on what?. ### Response: survival.


Instruction: What type of patients were comparing ACE-Is andARBs in?

Output: CKDpatients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of patients were comparing ACE-Is andARBs in?. ### Response: CKDpatients.


Instruction: What was there no clear difference between the effects of the two classes of drugs?

Output: cardiovascular out-comes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was there no clear difference between the effects of the two classes of drugs?. ### Response: cardiovascular out-comes.


Instruction: What could be an alternative method of monitoring?

Output: Imaging with echocardiography or cardiac MRI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could be an alternative method of monitoring?. ### Response: Imaging with echocardiography or cardiac MRI.


Instruction: What is the aim of this section of the review?

Output: to examine the clinical and cost -effectiveness of biomarker measurement or imaging in the management of heart failure in patients with CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the aim of this section of the review?. ### Response: to examine the clinical and cost -effectiveness of biomarker measurement or imaging in the management of heart failure in patients with CKD.


Instruction: What is the clinical and cost effectiveness of biomarker based monitoring in people with CKD?

Output: 8.2.2 Review question: What is the clinical and cost effectiveness of biomarker -based monitoring, monitoring with cardiac MRI, and monitoring with repeated echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the clinical and cost effectiveness of biomarker based monitoring in people with CKD?. ### Response: 8.2.2 Review question: What is the clinical and cost effectiveness of biomarker -based monitoring, monitoring with cardiac MRI, and monitoring with repeated echocardiography.


Instruction: What is a review protocol in Appendix?

Output: A

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a review protocol in Appendix?. ### Response: A.


Instruction: What is CKD?

Output: heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CKD?. ### Response: heart failure.


Instruction: What is the review protocol?

Output: Appendix  A

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the review protocol?. ### Response: Appendix  A.


Instruction: What percentage of blacks with elevated BP in the ED had subclinical hyper-tensive heart disease?

Output: 90%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of blacks with elevated BP in the ED had subclinical hyper-tensive heart disease?. ### Response: 90%.


Instruction: What is asymptomatic but many patients have target-organ injury?

Output: asymptom-atic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is asymptomatic but many patients have target-organ injury?. ### Response: asymptom-atic.


Instruction: What is performed in the ED for target-organ damage?

Output: screening tests

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is performed in the ED for target-organ damage?. ### Response: screening tests.


Instruction: What is done in selected patents?

Output: performing screening tests in the ED for target-organ damage and tests for identifiable causes of hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is done in selected patents?. ### Response: performing screening tests in the ED for target-organ damage and tests for identifiable causes of hypertension.


Instruction: Most asymptomatic patients will not require what?

Output: acute BP reduction or long-term antihypertensive medication initiation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Most asymptomatic patients will not require what?. ### Response: acute BP reduction or long-term antihypertensive medication initiation.


Instruction: What can the ED encounter do for newly diagnosed hypertensive patients?

Output: arranging appropriate referral

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can the ED encounter do for newly diagnosed hypertensive patients?. ### Response: arranging appropriate referral.


Instruction: When was this article published?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this article published?. ### Response: April 28, 2023.


Instruction: What was the percentage time out-of-INR range lower in the electronic reminder group than in controls?

Output: 0.64

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the percentage time out-of-INR range lower in the electronic reminder group than in controls?. ### Response: 0.64.


Instruction: What is the adjusted OR forlikelihood of being out of INR range?

Output: 0.77

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the adjusted OR forlikelihood of being out of INR range?. ### Response: 0.77.


Instruction: There was no difference in median days withincorrect adherence between electronic reminder and controlgroups?

Output: majorbleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There was no difference in median days withincorrect adherence between electronic reminder and controlgroups?. ### Response: majorbleeding.


Instruction: What was the difference in the fully adjusted model for percentageincorrect adherence?

Output: 22.0%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the difference in the fully adjusted model for percentageincorrect adherence?. ### Response: 22.0%.


Instruction: What was there no effect of electronic reminders on mortality and PE/DVT because these outcomes did not occur in any study?

Output: Harms and burden

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was there no effect of electronic reminders on mortality and PE/DVT because these outcomes did not occur in any study?. ### Response: Harms and burden.


Instruction: What was the difference in majorbleeding between the electronic reminders group and controls?

Output: There was no

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the difference in majorbleeding between the electronic reminders group and controls?. ### Response: There was no.


Instruction: How much more episodes were there per 1000?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much more episodes were there per 1000?. ### Response: 1.


Instruction: What would be the resource require-ments for an electronic reminder system?

Output: large

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would be the resource require-ments for an electronic reminder system?. ### Response: large.


Instruction: What would be a large resource requirement for the electronic reminder system?

Output: specialized equipment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would be a large resource requirement for the electronic reminder system?. ### Response: specialized equipment.


Instruction: What is likely not feasible to implement in most settings?

Output: electronic reminders

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is likely not feasible to implement in most settings?. ### Response: electronic reminders.


Instruction: What is the net benefit/harm of using electronic reminders to improve adherence to anticoagula-tion therapy for patients receiving treatment of VTE?

Output: burden

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the net benefit/harm of using electronic reminders to improve adherence to anticoagula-tion therapy for patients receiving treatment of VTE?. ### Response: burden.


Instruction: The panel suggests against using what?

Output: electronic reminders

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The panel suggests against using what?. ### Response: electronic reminders.


Instruction: See recommendation 13a for additional comments regarding adherence interventions ingeneral and what needs pertaining to this recommendation?

Output: research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: See recommendation 13a for additional comments regarding adherence interventions ingeneral and what needs pertaining to this recommendation?. ### Response: research.