Instruction: What is the difference between tricuspid and bicuspid valves?

Output: transcatheter aortic valve implantation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between tricuspid and bicuspid valves?. ### Response: transcatheter aortic valve implantation.


Instruction: In what year did Circulation issue 108(suppl 1):II291–4?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did Circulation issue 108(suppl 1):II291–4?. ### Response: 2003.


Instruction: What is Fate of nonreplaced sinuses of Valsalva in bicuspid aortic valve disease?

Output: 14. Park CB, Greason KL, Suri RM, et al. Fate of nonreplaced sinuses of Valsalva in bicuspid aortic valve disease. J Thorac Cardiovasc Surg. 2011;142:278–84

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Fate of nonreplaced sinuses of Valsalva in bicuspid aortic valve disease?. ### Response: 14. Park CB, Greason KL, Suri RM, et al. Fate of nonreplaced sinuses of Valsalva in bicuspid aortic valve disease. J Thorac Cardiovasc Surg. 2011;142:278–84.


Instruction: What is the J Thorac Cardiovasc Surg. 2011;142:278–84.

Output: Fate of nonreplaced sinuses of Valsalva in bicuspid aortic valve disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the J Thorac Cardiovasc Surg. 2011;142:278–84.. ### Response: Fate of nonreplaced sinuses of Valsalva in bicuspid aortic valve disease.


Instruction: What are the guidelines for management and quality measures?

Output: Aortic valve and ascending aorta

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the guidelines for management and quality measures?. ### Response: Aortic valve and ascending aorta.


Instruction: What is the name of the aortic valve that is repaired or replaced?

Output: bicuspid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the aortic valve that is repaired or replaced?. ### Response: bicuspid.


Instruction: How long has David TE, Feindel CM, David CM been doing?

Output: quarter of a century

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long has David TE, Feindel CM, David CM been doing?. ### Response: quarter of a century.


Instruction: What does J Thorac Cardiovasc Surg. 2014:148:872–9?

Output: aortic valve-sparing operations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does J Thorac Cardiovasc Surg. 2014:148:872–9?. ### Response: aortic valve-sparing operations.


Instruction: What are the characteristics of contemporary patients with bicuspid aortic valves?

Output: long-term outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the characteristics of contemporary patients with bicuspid aortic valves?. ### Response: long-term outcomes.


Instruction: How long has Schneider U, Feldner SK, Hofmann C, et al. had experience with root remodeling and valve repair?

Output: Two decades

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long has Schneider U, Feldner SK, Hofmann C, et al. had experience with root remodeling and valve repair?. ### Response: Two decades.


Instruction: What is Takagi's name?

Output: Nakatani S

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Takagi's name?. ### Response: Nakatani S.


Instruction: What type of aortic valves are used?

Output: bicuspid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of aortic valves are used?. ### Response: bicuspid.


Instruction: What is the name of the study that compares bicuspid versus tricuspid valves?

Output: Meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that compares bicuspid versus tricuspid valves?. ### Response: Meta-analysis.


Instruction: When was the last time a patient had a transcatheter valve replacement?

Output: A quarter of a century

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last time a patient had a transcatheter valve replacement?. ### Response: A quarter of a century.


Instruction: What is the name of the systematic review and meta-analysis that compares outcomes after transcatheter aortic valve replacement in patients with stenotic bi-cuspid and tricuspid?

Output: a systematic review and meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta-analysis that compares outcomes after transcatheter aortic valve replacement in patients with stenotic bi-cuspid and tricuspid?. ### Response: a systematic review and meta-analysis.


Instruction: What does Makkar RR, Yoon S-H, Leon MB, et al. have an association between?

Output: transcatheter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Makkar RR, Yoon S-H, Leon MB, et al. have an association between?. ### Response: transcatheter.


Instruction: What are the specific mechanisms leading to statin-associated diabetes mellitus unclear?

Output: statins directly cause diabetes mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the specific mechanisms leading to statin-associated diabetes mellitus unclear?. ### Response: statins directly cause diabetes mellitus.


Instruction: Is it likely that statins directly cause diabetes?

Output: it is unlikely

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Is it likely that statins directly cause diabetes?. ### Response: it is unlikely.


Instruction: What does a small number of individuals with diabetic susceptibility cross after statin therapy?

Output: the threshold to incident diabetes mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does a small number of individuals with diabetic susceptibility cross after statin therapy?. ### Response: the threshold to incident diabetes mellitus.


Instruction: When should patients be informed of the potential risk of new-onset diabetes mellitus?

Output: before initiation of statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When should patients be informed of the potential risk of new-onset diabetes mellitus?. ### Response: before initiation of statin therapy.


Instruction: The benefits of statin therapy outweigh the risks of what?

Output: new-onset diabetes mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The benefits of statin therapy outweigh the risks of what?. ### Response: new-onset diabetes mellitus.


Instruction: What should not be a contraindication to statin therapy or indication for statin discontinuation?

Output: incident diabetes mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not be a contraindication to statin therapy or indication for statin discontinuation?. ### Response: incident diabetes mellitus.


Instruction: In individuals at increased risk of both ASCVD and incident diabetes mellitus, it is recommended that counseling be provided based on what approach?

Output: ADA prevention approach

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In individuals at increased risk of both ASCVD and incident diabetes mellitus, it is recommended that counseling be provided based on what approach?. ### Response: ADA prevention approach.


Instruction: What does the ADA prevent approach encourage?

Output: regular moderate physical activity, maintaining a healthy dietary pattern, and sustaining modest weight loss

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the ADA prevent approach encourage?. ### Response: regular moderate physical activity, maintaining a healthy dietary pattern, and sustaining modest weight loss.


Instruction: What is the core principle of the Diabetes Prevention Program?

Output: sustaining modest weight loss

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the core principle of the Diabetes Prevention Program?. ### Response: sustaining modest weight loss.


Instruction: In patients with statin-associated side effects, what should be measured?

Output: CK

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with statin-associated side effects, what should be measured?. ### Response: CK.


Instruction: What should CK be measured in the case of severe SAMS and in the presence of objective mus-cle weakness?

Output: statin-associated side effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should CK be measured in the case of severe SAMS and in the presence of objective mus-cle weakness?. ### Response: statin-associated side effects.


Instruction: What does the FDA recommend measuring if there are signs or symptoms suggesting hepatotoxicity?

Output: transaminases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the FDA recommend measuring if there are signs or symptoms suggesting hepatotoxicity?. ### Response: transaminases.


Instruction: What is an infrequent statin-associated side effect that often resolves with dose reduc-tion or rechallenge with alternative statins?

Output: An asymptomatic increase in transaminases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an infrequent statin-associated side effect that often resolves with dose reduc-tion or rechallenge with alternative statins?. ### Response: An asymptomatic increase in transaminases.


Instruction: What is rare and not impacted by routine statin use?

Output: hepatotoxicity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is rare and not impacted by routine statin use?. ### Response: hepatotoxicity.


Instruction: What is rare?

Output: side effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is rare?. ### Response: side effects.


Instruction: What is not impacted by routine monitor-ing of transaminases?

Output: Severe statin-associated hepatotoxicity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not impacted by routine monitor-ing of transaminases?. ### Response: Severe statin-associated hepatotoxicity.


Instruction: A thorough evaluation for nonstatin etiologies is warranted when what persists?

Output: signifi-cant transaminase elevation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A thorough evaluation for nonstatin etiologies is warranted when what persists?. ### Response: signifi-cant transaminase elevation.


Instruction: Statins are not contraindicated in patients with increased ASCVD risk with what?

Output: chronic, stable liver dis-ease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Statins are not contraindicated in patients with increased ASCVD risk with what?. ### Response: chronic, stable liver dis-ease.


Instruction: What is an example of a liver dis-ease?

Output: nonalcoholic fatty liver

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a liver dis-ease?. ### Response: nonalcoholic fatty liver.


Instruction: What are statin-associated side effects rare?

Output: Severe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are statin-associated side effects rare?. ### Response: Severe.


Instruction: Recurrent SAMS are infrequent when a thorough reassessment and management strategy is used?

Output: Severe statin-associated side effects are rare

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Recurrent SAMS are infrequent when a thorough reassessment and management strategy is used?. ### Response: Severe statin-associated side effects are rare.


Instruction: What should nonstatin therapy be considered when there is net clinical benefit?

Output: In patients at increased ASCVD risk with severe statin-asso-ciated side effects or recurrent SAMS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should nonstatin therapy be considered when there is net clinical benefit?. ### Response: In patients at increased ASCVD risk with severe statin-asso-ciated side effects or recurrent SAMS.


Instruction: What remains chal-lenging given that the majority of symptoms are subjective and definitive diagnostic criteria do not exist?

Output: The clinical diagnosis of SAMS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What remains chal-lenging given that the majority of symptoms are subjective and definitive diagnostic criteria do not exist?. ### Response: The clinical diagnosis of SAMS.


Instruction: What does not exist?

Output: definitive diagnostic criteria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not exist?. ### Response: definitive diagnostic criteria.


Instruction: What has been suggested to contribute to SAMS?

Output: Multiple potential mechanisms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been suggested to contribute to SAMS?. ### Response: Multiple potential mechanisms.


Instruction: When will SAMS be downloaded?

Output: May 1, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When will SAMS be downloaded?. ### Response: May 1, 2023.


Instruction: What is the name of the 2018 ACHD GuidelineCirculation?

Output: Stout et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2018 ACHD GuidelineCirculation?. ### Response: Stout et al.


Instruction: What is an anomalous left coro-nary artery from the pulmonary artery?

Output: saphenous vein graft

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an anomalous left coro-nary artery from the pulmonary artery?. ### Response: saphenous vein graft.


Instruction: What is the name of the operation for anomalous left coro-nary artery from the pulmonary artery?

Output: saphenous vein graft

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the operation for anomalous left coro-nary artery from the pulmonary artery?. ### Response: saphenous vein graft.


Instruction: When was the J Thorac Cardiovasc Surg. 1999;117:332–42?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Thorac Cardiovasc Surg. 1999;117:332–42?. ### Response: 1999.


Instruction: Exercise performance after repair of anomalous origin of the left coronary artery is what?

Output: Long-term results

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Exercise performance after repair of anomalous origin of the left coronary artery is what?. ### Response: Long-term results.


Instruction: Circulation. 1990;81:1287–92.

Output: Exercise performance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation. 1990;81:1287–92.. ### Response: Exercise performance.


Instruction: What year did Circulation.81:1287–92. S4.4.7.3-3. Lange R, Vogt M, Hörer J, et al. Long-term results of repair of anomalous origin of the left coronary artery from the pulmonary artery.

Output: 1990

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Circulation.81:1287–92. S4.4.7.3-3. Lange R, Vogt M, Hörer J, et al. Long-term results of repair of anomalous origin of the left coronary artery from the pulmonary artery.. ### Response: 1990.


Instruction: What year was Ann Thorac Surg.83:1463–71.

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was Ann Thorac Surg.83:1463–71.. ### Response: 2007.


Instruction: What was the early and late result of saphenous vein graft for anomalous origin of left coronary artery from pulmonary artery?

Output: Exercise performance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the early and late result of saphenous vein graft for anomalous origin of left coronary artery from pulmonary artery?. ### Response: Exercise performance.


Instruction: Circulation. 1973;48:III2–6. S4.4.7.3-5.

Output: Early and late result of saphenous vein graft for anomalous origin of left coronary artery from pulmonary artery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation. 1973;48:III2–6. S4.4.7.3-5.. ### Response: Early and late result of saphenous vein graft for anomalous origin of left coronary artery from pulmonary artery.


Instruction: What did Wilson CL, Dlabal PW, McGuire SA do?

Output: Surgical treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Wilson CL, Dlabal PW, McGuire SA do?. ### Response: Surgical treatment.


Instruction: How many adult cases of anomalous origin of the left coronary artery from the pulmonary artery were reviewed?

Output: 151

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many adult cases of anomalous origin of the left coronary artery from the pulmonary artery were reviewed?. ### Response: 151.


Instruction: What year did Clin Cardiol. 2011:34:204-10?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Clin Cardiol. 2011:34:204-10?. ### Response: 2011.


Instruction: How old was the woman?

Output: 53

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old was the woman?. ### Response: 53.


Instruction: What was the age range of the woman in the study?

Output: 53

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the age range of the woman in the study?. ### Response: 53.


Instruction: Who was the author of Surgical strategies for anomalous origin of coronary artery in adults?

Output: Rajbanshi

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the author of Surgical strategies for anomalous origin of coronary artery in adults?. ### Response: Rajbanshi.


Instruction: How many adult patients underwent coronary angiography?

Output: 12,457

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many adult patients underwent coronary angiography?. ### Response: 12,457.


Instruction: What was the prevalence of coronary artery anomalies in 12,457 adult patients?

Output: Prevalence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the prevalence of coronary artery anomalies in 12,457 adult patients?. ### Response: Prevalence.


Instruction: What is a word of caution in repair of congenital coronary artery fistulas?

Output: Late outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a word of caution in repair of congenital coronary artery fistulas?. ### Response: Late outcome.


Instruction: What is an EVIDENCE GAPS AND FUTURE DIRECTIONS S5-1?

Output: Emerging research direc-tions in adult congenital heart disease: a report from an NHLBI/ACHA Working Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an EVIDENCE GAPS AND FUTURE DIRECTIONS S5-1?. ### Response: Emerging research direc-tions in adult congenital heart disease: a report from an NHLBI/ACHA Working Group.


Instruction: What is the name of the working group that developed research direc-tions in adult congenital heart disease?

Output: NHLBI/ACHA Working Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the working group that developed research direc-tions in adult congenital heart disease?. ### Response: NHLBI/ACHA Working Group.


Instruction: When was this report released?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this report released?. ### Response: April 28, 2023.


Instruction: What is ahajournals.org?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ahajournals.org?. ### Response: http://ahajournals.org.


Instruction: What is LADA?

Output: latent autoimmune diabetes in adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is LADA?. ### Response: latent autoimmune diabetes in adults.


Instruction: What are LADA and type 2 diabetes?

Output: Sweetened bever -age intake and risk of latent autoimmune diabetes in adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are LADA and type 2 diabetes?. ### Response: Sweetened bever -age intake and risk of latent autoimmune diabetes in adults.


Instruction: How many people in the U.S. are obese?

Output: 187–225

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people in the U.S. are obese?. ### Response: 187–225.


Instruction: Which type of diabetes is more likely to develop?

Output: type 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which type of diabetes is more likely to develop?. ### Response: type 2.


Instruction: What is the association between sugar intake and car -diovascular diseases mortality among US adults?

Output: Added sugar intake

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association between sugar intake and car -diovascular diseases mortality among US adults?. ### Response: Added sugar intake.


Instruction: What is a sci-ence advisory from the American Heart Association?

Output: Low-calorie sweetened beverages and cardiometabolic health

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a sci-ence advisory from the American Heart Association?. ### Response: Low-calorie sweetened beverages and cardiometabolic health.


Instruction: What is associated with hazard of acute coronary heart disease in the Reasons for Geographic and Racial Differences in Stroke study?

Output: Southern dietary pat-tern

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with hazard of acute coronary heart disease in the Reasons for Geographic and Racial Differences in Stroke study?. ### Response: Southern dietary pat-tern.


Instruction: Circulation. 2015;132:804–14. S3.1-22. What is a prospective study of diet carbohydrate intake and mortality?

Output: a prospective cohort study and meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation. 2015;132:804–14. S3.1-22. What is a prospective study of diet carbohydrate intake and mortality?. ### Response: a prospective cohort study and meta-analysis.


Instruction: What is a prospective cohort study and meta-analysis of?

Output: Dietary carbohydrate intake and mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a prospective cohort study and meta-analysis of?. ### Response: Dietary carbohydrate intake and mortality.


Instruction: What is the name of the study that examined the relationship between carbohydrate intake and mortality?

Output: prospective cohort study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined the relationship between carbohydrate intake and mortality?. ### Response: prospective cohort study.


Instruction: How many people were enrolled in the Eur J Clin Nutr 2007?

Output: 61:575–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were enrolled in the Eur J Clin Nutr 2007?. ### Response: 61:575–.


Instruction: What did Clin Nutr. 2007:61:575–81?

Output: Eur J

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Clin Nutr. 2007:61:575–81?. ### Response: Eur J.


Instruction: What did Noto H, Goto A, Tsujimoto T, et al. study low-carbohydrate diets and all-cause mortality: a systematic review and meta-analysis of observa-tional studies?

Output: PLoS ONE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Noto H, Goto A, Tsujimoto T, et al. study low-carbohydrate diets and all-cause mortality: a systematic review and meta-analysis of observa-tional studies?. ### Response: PLoS ONE.


Instruction: How did Brandt EJ, Myerson R, Perraillon MC, and others compare hospital admissions for myocardial infarction and stroke?

Output: before and after the trans-fatty acid restrictions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Brandt EJ, Myerson R, Perraillon MC, and others compare hospital admissions for myocardial infarction and stroke?. ### Response: before and after the trans-fatty acid restrictions.


Instruction: What type of myocardial infarction did New York have before and after the trans-fatty acid restrictions?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of myocardial infarction did New York have before and after the trans-fatty acid restrictions?. ### Response: stroke.


Instruction: What is the JAMA Cardiol. 2017 2:627-34?

Output: Hospital admissions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the JAMA Cardiol. 2017 2:627-34?. ### Response: Hospital admissions.


Instruction: Micha R, Mozaffarian D. What are the effects of trans fatty acids on meta-bolic syndrome, heart disease and diabetes?

Output: S3.1-27

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Micha R, Mozaffarian D. What are the effects of trans fatty acids on meta-bolic syndrome, heart disease and diabetes?. ### Response: S3.1-27.


Instruction: What is a comprehensive review of dietary and policy priorities for cardiovascular dis-ease, diabetes, and obesity?

Output: Circulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a comprehensive review of dietary and policy priorities for cardiovascular dis-ease, diabetes, and obesity?. ### Response: Circulation.


Instruction: What are the trends and projections in the United States, 1969-2020?

Output: Heart disease and cancer deaths

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the trends and projections in the United States, 1969-2020?. ### Response: Heart disease and cancer deaths.


Instruction: What is the name of the systematic review and meta-analysis of red and processed meat con-sumption and risk of incident coronary heart disease, stroke, and diabetes mellitus?

Output: Micha R, Wallace SK, Mozaffarian D. Red and processed meat con-sumption and risk of incident coronary heart disease, stroke, and diabetes mellitus: a systematic review and meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta-analysis of red and processed meat con-sumption and risk of incident coronary heart disease, stroke, and diabetes mellitus?. ### Response: Micha R, Wallace SK, Mozaffarian D. Red and processed meat con-sumption and risk of incident coronary heart disease, stroke, and diabetes mellitus: a systematic review and meta-analysis.


Instruction: When did Circulation. 2010:121:2271–83.

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circulation. 2010:121:2271–83.. ### Response: 2016.


Instruction: What is a recommended dietary pattern to achieve adherence to the American Dietary Guidelines?

Output: Low-carbohydrate-high-protein diet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a recommended dietary pattern to achieve adherence to the American Dietary Guidelines?. ### Response: Low-carbohydrate-high-protein diet.


Instruction: What is the acronym for the American Heart Association/American College of Cardiology?

Output: AHA/ACC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the American Heart Association/American College of Cardiology?. ### Response: AHA/ACC.


Instruction: What is a scien-tific statement from the AHA/ACC?

Output: Recommended dietary pattern to achieve adherence to the American Heart Association/American College of Cardiology (AHA/ACC) guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a scien-tific statement from the AHA/ACC?. ### Response: Recommended dietary pattern to achieve adherence to the American Heart Association/American College of Cardiology (AHA/ACC) guidelines.


Instruction: When was the Circulation. 2016;134:e505-29?

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circulation. 2016;134:e505-29?. ### Response: 2016.


Instruction: What is a science advisory from the American Heart Association?

Output: Seafood long-chain n-3 polyun-saturated fatty acids and cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a science advisory from the American Heart Association?. ### Response: Seafood long-chain n-3 polyun-saturated fatty acids and cardiovascular disease.


Instruction: What is the association of dairy intake with cardiovascular disease and mortality in 21 countries from five continents?

Output: PURE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association of dairy intake with cardiovascular disease and mortality in 21 countries from five continents?. ### Response: PURE.


Instruction: What is powder/paste cocaine associated with?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is powder/paste cocaine associated with?. ### Response: stroke.


Instruction: What is the CARDIA study?

Output: Coronary Artery Risk Development in Young Adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the CARDIA study?. ### Response: Coronary Artery Risk Development in Young Adults.


Instruction: What is the risk of stroke/TIA?

Output: no significant risk for stroke/TIA as a result of cumulative lifetime can-nabis use of ≥ 5 years or recent use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of stroke/TIA?. ### Response: no significant risk for stroke/TIA as a result of cumulative lifetime can-nabis use of ≥ 5 years or recent use.


Instruction: What is higher among cannabis users?

Output: Acute ischemic stroke hospitalization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is higher among cannabis users?. ### Response: Acute ischemic stroke hospitalization.


Instruction: How long is cannabis use cumulative?

Output: ≥ 5 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is cannabis use cumulative?. ### Response: ≥ 5 years.


Instruction: What are the odds of stroke among young adults with recent cannabis use?

Output: higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the odds of stroke among young adults with recent cannabis use?. ### Response: higher.


Instruction: What is the adjusted OR of cannabis use among nonus-ers?

Output: 1.82

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the adjusted OR of cannabis use among nonus-ers?. ### Response: 1.82.


Instruction: What is a chronic relapsing brain disease characterized by compulsive use, loss of control over intake, and a negative emo-tional state when not using?

Output: alcohol or drug use disorder

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a chronic relapsing brain disease characterized by compulsive use, loss of control over intake, and a negative emo-tional state when not using?. ### Response: alcohol or drug use disorder.


Instruction: What is required to manage an alcohol or drug use disorder?

Output: special-ized care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is required to manage an alcohol or drug use disorder?. ### Response: special-ized care.


Instruction: What type of care is required to manage substance dependency?

Output: special-ized

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of care is required to manage substance dependency?. ### Response: special-ized.


Instruction: What is recommended in alcohol use disorders?

Output: established screening and counseling strategies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended in alcohol use disorders?. ### Response: established screening and counseling strategies.


Instruction: In what year was the US Preventive Services Task Force update?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was the US Preventive Services Task Force update?. ### Response: 2004.


Instruction: What are effective in the management of drug dependency?

Output: Long-term treatment strategies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are effective in the management of drug dependency?. ### Response: Long-term treatment strategies.


Instruction: What draw from convincing primary prevention data and broader CVD populations?

Output: Lifestyle recommendations in stroke secondary pre-vention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What draw from convincing primary prevention data and broader CVD populations?. ### Response: Lifestyle recommendations in stroke secondary pre-vention.


Instruction: Recurrent stroke lacks robust evidence supporting what?

Output: interventions addressing smoking and diet/nutrition

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Recurrent stroke lacks robust evidence supporting what?. ### Response: interventions addressing smoking and diet/nutrition.


Instruction: How are interventions limited to non-disabling stroke in physical activity?

Output: absent for substance use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are interventions limited to non-disabling stroke in physical activity?. ### Response: absent for substance use.


Instruction: What is absent for substance use?

Output: Recurrent stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is absent for substance use?. ### Response: Recurrent stroke.


Instruction: Future research in established stroke or TIA is required for what?

Output: To identify the effects on recurrent stroke of proven dietary interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Future research in established stroke or TIA is required for what?. ### Response: To identify the effects on recurrent stroke of proven dietary interventions.


Instruction: What diets are used to identify the effects on recurrent stroke?

Output: Mediterranean or DASH diets

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What diets are used to identify the effects on recurrent stroke?. ### Response: Mediterranean or DASH diets.


Instruction: What is the most efficacious and safe target for dietary sodium reduction?

Output: potassium increase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most efficacious and safe target for dietary sodium reduction?. ### Response: potassium increase.


Instruction: What is the purpose of this study?

Output: To identify the effects on recurrent stroke of proven dietary interventions (eg, Mediterranean or DASH diets) compared with usual care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of this study?. ### Response: To identify the effects on recurrent stroke of proven dietary interventions (eg, Mediterranean or DASH diets) compared with usual care.


Instruction: What is one of the activities to be trialed?

Output: breaking sedentary time

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the activities to be trialed?. ### Response: breaking sedentary time.


Instruction: When will this study be published?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When will this study be published?. ### Response: April 28, 2023.


Instruction: What can be done to reduce the need for fur in vestigations f or some w omen?

Output: identifying more women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be done to reduce the need for fur in vestigations f or some w omen?. ### Response: identifying more women.


Instruction: Moving fr om 2 4-hour urine collection t o spot urine A CR or PCR will save time?

Output: faster diagnosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Moving fr om 2 4-hour urine collection t o spot urine A CR or PCR will save time?. ### Response: faster diagnosis.


Instruction: How long does it take to complete a 2 4-hour urine A CR or PCR?

Output: time-consuming

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take to complete a 2 4-hour urine A CR or PCR?. ### Response: time-consuming.


Instruction: What is a r eduction in inaccuracies because of incomplet e samples?

Output: 2 4-hour urine collection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a r eduction in inaccuracies because of incomplet e samples?. ### Response: 2 4-hour urine collection.


Instruction: How long is it to complete a 2 4-hour urine collection?

Output: time-consuming

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is it to complete a 2 4-hour urine collection?. ### Response: time-consuming.


Instruction: A PCR of 30 mg/mmol is alr eady used as what?

Output: a diagnostic t hreshold

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A PCR of 30 mg/mmol is alr eady used as what?. ### Response: a diagnostic t hreshold.


Instruction: What should not change practice?

Output: 30  mg/mmol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not change practice?. ### Response: 30  mg/mmol.


Instruction: How many mg/mmol will standar dise practice?

Output: 8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mg/mmol will standar dise practice?. ### Response: 8.


Instruction: What has been made for the use of either A CR or PCR allowing local decisions?

Output: Recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been made for the use of either A CR or PCR allowing local decisions?. ### Response: Recommendations.


Instruction: What should not aff ect practice?

Output: A CR or PCR allo wing local decisions t o use whiche ver test

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not aff ect practice?. ### Response: A CR or PCR allo wing local decisions t o use whiche ver test.


Instruction: Repeating a PCR or A CR test ma y incur a small additional cost?

Output: Ho wever, this should reduce t he false positiv e rat e

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Repeating a PCR or A CR test ma y incur a small additional cost?. ### Response: Ho wever, this should reduce t he false positiv e rat e.


Instruction: What should reduce t he false positiv e rat e?

Output: Ho wever

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should reduce t he false positiv e rat e?. ### Response: Ho wever.


Instruction: What will a void unnecessar y follow-up or intensiv e monitoring do?

Output: if t heir pr oteinuria r esolv es and is sho wn to be transient

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will a void unnecessar y follow-up or intensiv e monitoring do?. ### Response: if t heir pr oteinuria r esolv es and is sho wn to be transient.


Instruction: What is sho wn to be transient?

Output: pr oteinuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is sho wn to be transient?. ### Response: pr oteinuria.


Instruction: Full details of the evidence and t he committee's discussion ar e in evidence r eview G: assessment of pr oteinuria

Output: commendations on t he values specified in t he recent Contr ol of Hyper tension in Pr egnancy Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Full details of the evidence and t he committee's discussion ar e in evidence r eview G: assessment of pr oteinuria. ### Response: commendations on t he values specified in t he recent Contr ol of Hyper tension in Pr egnancy Study.


Instruction: Why did the c ommi ttee make the recommendations?

Output: local decisions t o use whiche ver test is a vailable

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why did the c ommi ttee make the recommendations?. ### Response: local decisions t o use whiche ver test is a vailable.


Instruction: What should be offered lifestyle advice similar t o other adult s?

Output: The committ ee agr eed t hat pr egnant w oman wit h chr onic h yper tension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be offered lifestyle advice similar t o other adult s?. ### Response: The committ ee agr eed t hat pr egnant w oman wit h chr onic h yper tension.


Instruction: What is the NICE guideline on hyper tension in adult s?

Output: in line wit h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the NICE guideline on hyper tension in adult s?. ### Response: in line wit h.


Instruction: What was v ery little evidence a vailable on tr eatment initiation?

Output: Ther e

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was v ery little evidence a vailable on tr eatment initiation?. ### Response: Ther e.


Instruction: What does CHIPS stand for?

Output: Contr ol of Hyper tension in Pr egnancy Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CHIPS stand for?. ### Response: Contr ol of Hyper tension in Pr egnancy Study.


Instruction: What does NICE Hyper tension in pr egnancy mean?

Output: diagnosis and management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does NICE Hyper tension in pr egnancy mean?. ### Response: diagnosis and management.


Instruction: What is CHIPS?

Output: Contr ol of Hyper tension in Pr egnancy Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CHIPS?. ### Response: Contr ol of Hyper tension in Pr egnancy Study.


Instruction: What is NICE Hyper tension in pregnancy: diagnosis and management?

Output: guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE Hyper tension in pregnancy: diagnosis and management?. ### Response: guideline.


Instruction: When was the last updat ed?

Output: 17 April 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last updat ed?. ### Response: 17 April 2023.


Instruction: What is a strong trend for reduction in composite adverse events with the addition of parenteral UFH to aspirin therapy?

Output: those studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a strong trend for reduction in composite adverse events with the addition of parenteral UFH to aspirin therapy?. ### Response: those studies.


Instruction: What can provide more predictable anticoagulation327 than a fixed initial dose?

Output: weight-adjusted dosing regi-men of UFH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can provide more predictable anticoagulation327 than a fixed initial dose?. ### Response: weight-adjusted dosing regi-men of UFH.


Instruction: What is more predictable anticoagulation327 than a fixed initial dose?

Output: weight-adjusted dosing regi-men of UFH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more predictable anticoagulation327 than a fixed initial dose?. ### Response: weight-adjusted dosing regi-men of UFH.


Instruction: What is the recommended weight-adjusted regimen?

Output: an initial loading dose of 60 IU/kg (maximum 4000 IU) and an initial infusion of 12 IU/kg/h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommended weight-adjusted regimen?. ### Response: an initial loading dose of 60 IU/kg (maximum 4000 IU) and an initial infusion of 12 IU/kg/h.


Instruction: How is the initial loading dose adjusted?

Output: using a standardized nomogram

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the initial loading dose adjusted?. ### Response: using a standardized nomogram.


Instruction: What is Argatroban?

Output: a direct thrombin inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Argatroban?. ### Response: a direct thrombin inhibitor.


Instruction: How long after intravenous administration is steady state plasma concentrations achieved?

Output: 1 to 3 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after intravenous administration is steady state plasma concentrations achieved?. ### Response: 1 to 3 hours.


Instruction: What is argatroboan indicated for?

Output: pro-phylaxis or treatment of thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is argatroboan indicated for?. ### Response: pro-phylaxis or treatment of thrombosis.


Instruction: What can be used in patients with renal insuffi-ciency?

Output: argatroban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be used in patients with renal insuffi-ciency?. ### Response: argatroban.


Instruction: What is the usual dose of argatroban?

Output: 2 mcg/kg per minute

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the usual dose of argatroban?. ### Response: 2 mcg/kg per minute.


Instruction: How long is activated partial thromboplastin time?

Output: 1.5 to 3 times baseline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is activated partial thromboplastin time?. ### Response: 1.5 to 3 times baseline.


Instruction: What should not be used in patients with NSTE-ACS?

Output: intravenous fibrinolytic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not be used in patients with NSTE-ACS?. ### Response: intravenous fibrinolytic therapy.


Instruction: How many times baseline?

Output: 1.5 to 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many times baseline?. ### Response: 1.5 to 3.


Instruction: What is the level of evidence for fibrinolytic therapy?

Output: There was no benefit for mortality or MI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the level of evidence for fibrinolytic therapy?. ### Response: There was no benefit for mortality or MI.


Instruction: What is the level of evidence for fibrinolytic therapy in NSTE-ACS?

Output: Class III: Harm1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the level of evidence for fibrinolytic therapy in NSTE-ACS?. ### Response: Class III: Harm1.


Instruction: What was evaluated by the Fibrinolytic Trialists and TIMI investigators?

Output: Fibrinolysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was evaluated by the Fibrinolytic Trialists and TIMI investigators?. ### Response: Fibrinolysis.


Instruction: There was no benefit for mortality or MI.

Output: fibrinolytic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There was no benefit for mortality or MI.. ### Response: fibrinolytic therapy.


Instruction: What is a benefit for mortality or MI?

Output: reduction in composite adverse events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a benefit for mortality or MI?. ### Response: reduction in composite adverse events.


Instruction: Intracranial hemorrhage and fatal and nonfatal MI occur more frequently in patients treated with fibrinolytic therapy?

Output: 93,329

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Intracranial hemorrhage and fatal and nonfatal MI occur more frequently in patients treated with fibrinolytic therapy?. ### Response: 93,329.


Instruction: See Online Data Supplement 17 for additional information on what?

Output: parenteral anticoagulant and fibrinolytic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: See Online Data Supplement 17 for additional information on what?. ### Response: parenteral anticoagulant and fibrinolytic therapy.


Instruction: What is the management algorithm for ischemia-guided versus early invasive strategies?

Output: Figure 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the management algorithm for ischemia-guided versus early invasive strategies?. ### Response: Figure 3.


Instruction: How many treatment pathways have emerged for all patients with NSTE-ACS?

Output: Two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many treatment pathways have emerged for all patients with NSTE-ACS?. ### Response: Two.


Instruction: What triages patients to an inva-sive diagnostic evaluation?

Output: invasive strategy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What triages patients to an inva-sive diagnostic evaluation?. ### Response: invasive strategy.


Instruction: Angina at rest or with minimal activity despite vigorous medical therapy are examples of what?

Output: fail medical therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Angina at rest or with minimal activity despite vigorous medical therapy are examples of what?. ### Response: fail medical therapy.


Instruction: What is the initial ischemia-guided strategy called for for patients who fail medical therapy?

Output: an inva-sive evaluation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the initial ischemia-guided strategy called for for patients who fail medical therapy?. ### Response: an inva-sive evaluation.


Instruction: What can be directed at the accessory pathway or the A V node?

Output: patients with orthodromic A VRT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be directed at the accessory pathway or the A V node?. ### Response: patients with orthodromic A VRT.


Instruction: What may be contraindicated in patients at risk of rapid conduction?

Output: A V nodal–blocking agents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be contraindicated in patients at risk of rapid conduction?. ### Response: A V nodal–blocking agents.


Instruction: What may be contraindicated in patients at risk of rapid conduction down the accessory pathway during AF?

Output: A V nodal–blocking agents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be contraindicated in patients at risk of rapid conduction down the accessory pathway during AF?. ### Response: A V nodal–blocking agents.


Instruction: Catheter ablation strategies target what pathway with high success rates?

Output: accessory pathway

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Catheter ablation strategies target what pathway with high success rates?. ### Response: accessory pathway.


Instruction: What is Figure 14 for the algorithm for acute treatment of?

Output: ortho-dromic A VRT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Figure 14 for the algorithm for acute treatment of?. ### Response: ortho-dromic A VRT.


Instruction: What is the algorithm for acute treatment of ortho-dromic A VRT?

Output: Figure 14

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the algorithm for acute treatment of ortho-dromic A VRT?. ### Response: Figure 14.


Instruction: What is Figure 15 for?

Output: the algorithm for ongoing management of orthodromic A VRT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Figure 15 for?. ### Response: the algorithm for ongoing management of orthodromic A VRT.


Instruction: What can be performed for acute conversion of orthodromic AVRT?

Output: Vagal maneuvers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be performed for acute conversion of orthodromic AVRT?. ### Response: Vagal maneuvers.


Instruction: What should be performed with the patient in the first line to terminate SVT?

Output: vagal maneuvers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be performed with the patient in the first line to terminate SVT?. ### Response: vagal maneuvers.


Instruction: What position should the patient be in during Valsalva maneuvers?

Output: supine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What position should the patient be in during Valsalva maneuvers?. ### Response: supine.


Instruction: There is no “gold standard” for what maneuver technique?

Output: Valsalva

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is no “gold standard” for what maneuver technique?. ### Response: Valsalva.


Instruction: How long does the patient bear down against a closed glottis?

Output: 10 to 30 seconds

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does the patient bear down against a closed glottis?. ### Response: 10 to 30 seconds.


Instruction: What is the equivalent of 10 to 30 seconds?

Output: 30 to 40 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the equivalent of 10 to 30 seconds?. ### Response: 30 to 40 mm Hg.


Instruction: How long is a carotid massage performed?

Output: 5 to 10 seconds

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is a carotid massage performed?. ### Response: 5 to 10 seconds.


Instruction: How long does it take to apply steady pressure over the right or left cranial sinus?

Output: 5 to 10 seconds

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take to apply steady pressure over the right or left cranial sinus?. ### Response: 5 to 10 seconds.


Instruction: What is another vagal maneuver based on?

Output: Valsalva

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another vagal maneuver based on?. ### Response: Valsalva.


Instruction: What is another vagal maneuver based on the classic diving reflex?

Output: Valsalva

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another vagal maneuver based on the classic diving reflex?. ### Response: Valsalva.


Instruction: What does applying an ice-cold, wet towel to the face consist of?

Output: vagal maneuver

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does applying an ice-cold, wet towel to the face consist of?. ### Response: vagal maneuver.


Instruction: In a laboratory setting, what has proved effective in terminating tachycardia?

Output: facial immersion in water

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In a laboratory setting, what has proved effective in terminating tachycardia?. ### Response: facial immersion in water.


Instruction: One study involving 148 patients with SVT demonstrated that Valsalva was more effective than what?

Output: carotid sinus massage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: One study involving 148 patients with SVT demonstrated that Valsalva was more effective than what?. ### Response: carotid sinus massage.


Instruction: How many patients with SVT received Valsalva?

Output: 148

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with SVT received Valsalva?. ### Response: 148.


Instruction: What was the overall success rate of the Valsalvan technique?

Output: 27.7%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the overall success rate of the Valsalvan technique?. ### Response: 27.7%..


Instruction: The practice of applying pressure to the eyeball has been abandoned, what is it?

Output: potentially dangerous

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The practice of applying pressure to the eyeball has been abandoned, what is it?. ### Response: potentially dangerous.


Instruction: Which technique was more successful than carotid sinus massage?

Output: Valsalva

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which technique was more successful than carotid sinus massage?. ### Response: Valsalva.


Instruction: What is beneficial for acute treatment in patients with orthodromic AVRT?

Output: Vagal maneuvers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is beneficial for acute treatment in patients with orthodromic AVRT?. ### Response: Vagal maneuvers.


Instruction: What percentage of patients have adenosine effective for conversion?

Output: 90% to 95%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients have adenosine effective for conversion?. ### Response: 90% to 95%.


Instruction: How long does it take for side effects to occur?

Output: (<1 min

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take for side effects to occur?. ### Response: (<1 min.


Instruction: What percentage of patients have minor and brief side effects?

Output: 30%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients have minor and brief side effects?. ### Response: 30%.


Instruction: Patients often have atrial or ventricular premature complexes immediately after conversion that may induce further episodes of what?

Output: AVRT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients often have atrial or ventricular premature complexes immediately after conversion that may induce further episodes of what?. ### Response: AVRT.


Instruction: What may be required to prevent acute reinitiation of tachycardia?

Output: antiarrhythmic drug

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be required to prevent acute reinitiation of tachycardia?. ### Response: antiarrhythmic drug.


Instruction: What may precipitate AF that may then conduct rapidly to the ventricle and cause ventricular fibrillation?

Output: adenosine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may precipitate AF that may then conduct rapidly to the ventricle and cause ventricular fibrillation?. ### Response: adenosine.


Instruction: Why should electrical cardioversion be available?

Output: adenosine may precipitate AF that may then conduct rapidly to the ventricle and even cause ventricular fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why should electrical cardioversion be available?. ### Response: adenosine may precipitate AF that may then conduct rapidly to the ventricle and even cause ventricular fibrillation.


Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al.


Instruction: When was tricuspid valve surgery performed for severe TR his-torically performed?

Output: late in the natural history of the disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was tricuspid valve surgery performed for severe TR his-torically performed?. ### Response: late in the natural history of the disease.


Instruction: What has been performed relatively late in the natural history of HF?

Output: Isolated tricuspid valve surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been performed relatively late in the natural history of HF?. ### Response: Isolated tricuspid valve surgery.


Instruction: What has unadjusted mortality rates exceeded for isolated tricuspid valve surgery?

Output: those reported for isolated aortic or mitral valve surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has unadjusted mortality rates exceeded for isolated tricuspid valve surgery?. ### Response: those reported for isolated aortic or mitral valve surgery.


Instruction: What type of valve surgery has a higher mortality rate than mitral valve surgery?

Output: isolated tricuspid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of valve surgery has a higher mortality rate than mitral valve surgery?. ### Response: isolated tricuspid.


Instruction: What is the reason for the high reoperative mortality rate?

Output: advanced nature of RV failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the reason for the high reoperative mortality rate?. ### Response: advanced nature of RV failure.


Instruction: Why is this high mortality rate related to RV failure?

Output: advanced nature

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is this high mortality rate related to RV failure?. ### Response: advanced nature.


Instruction: What has influenced decision-making for initial repair of functional TR at the time of left-sided valve surgery?

Output: The hazards imposed by reoperation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has influenced decision-making for initial repair of functional TR at the time of left-sided valve surgery?. ### Response: The hazards imposed by reoperation.


Instruction: What did the hazards imposed by reoperation try to prevent?

Output: development of severe TR later after the left-sided valve surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the hazards imposed by reoperation try to prevent?. ### Response: development of severe TR later after the left-sided valve surgery.


Instruction: What may improve symptoms of right-sided HF if done before the onset of severe RV dysfunc-tion?

Output: operation for severe symptomatic isolated TR years after surgery for left-sided disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may improve symptoms of right-sided HF if done before the onset of severe RV dysfunc-tion?. ### Response: operation for severe symptomatic isolated TR years after surgery for left-sided disease.


Instruction: If there is no significant pulmonary hypertension or severe RV systolic dysfunction, operation for severe symptomatic isolated TR years after surgery for left-sided disease may improve what?

Output: symptoms of right-sided HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: If there is no significant pulmonary hypertension or severe RV systolic dysfunction, operation for severe symptomatic isolated TR years after surgery for left-sided disease may improve what?. ### Response: symptoms of right-sided HF.


Instruction: What is a common cause of RV dysfunction or end-organ damage?

Output: hepatic or renal dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a common cause of RV dysfunction or end-organ damage?. ### Response: hepatic or renal dysfunction.


Instruction: What is the cause of PULMONIC VALVE DISEASESee guidelines for the management of adults with con-genital heart disease?

Output: absence of RV dysfunction or pulmo-nary hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cause of PULMONIC VALVE DISEASESee guidelines for the management of adults with con-genital heart disease?. ### Response: absence of RV dysfunction or pulmo-nary hypertension.


Instruction: What is TTE recommended for patients with mixed valve disease?

Output: to assess the etiology, severity, and pathophysiological impact

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is TTE recommended for patients with mixed valve disease?. ### Response: to assess the etiology, severity, and pathophysiological impact.


Instruction: What is recommended to assess the etiology, severity, and pathophysiological impact?

Output: TTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended to assess the etiology, severity, and pathophysiological impact?. ### Response: TTE.


Instruction: What is stenosis and regurgita-tion of a single valve?

Output: Mixed valve disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is stenosis and regurgita-tion of a single valve?. ### Response: Mixed valve disease.


Instruction: What is mixed valve disease?

Output: stenosis and regurgita-tion of a single valve or 2) stenosis or regurgitation of 2 separate valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is mixed valve disease?. ### Response: stenosis and regurgita-tion of a single valve or 2) stenosis or regurgitation of 2 separate valves.


Instruction: What is stenosis or regurgitation of 2 separate valves?

Output: Mixed valve disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is stenosis or regurgitation of 2 separate valves?. ### Response: Mixed valve disease.


Instruction: What presents a special diagnostic challenge to the clinician in assessing the impact of the lesions on cardiac remodeling, ventricular function, and timing of intervention?

Output: Mixed valve disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What presents a special diagnostic challenge to the clinician in assessing the impact of the lesions on cardiac remodeling, ventricular function, and timing of intervention?. ### Response: Mixed valve disease.


Instruction: For many patients with mixed valve disease, there is a predominant valve lesion (ie, what?

Output: stenosis versus regurgitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For many patients with mixed valve disease, there is a predominant valve lesion (ie, what?. ### Response: stenosis versus regurgitation.


Instruction: What is a predominant valve lesion?

Output: stenosis versus regurgitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a predominant valve lesion?. ### Response: stenosis versus regurgitation.


Instruction: What causes chamber dilation and eccentric hypertrophy?

Output: volume overloads

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes chamber dilation and eccentric hypertrophy?. ### Response: volume overloads.


Instruction: When does pressure overload predominate?

Output: When pres-sure overload

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When does pressure overload predominate?. ### Response: When pres-sure overload.


Instruction: What is the 2017 ACC/AHA/HFSA Heart Failure Focused UpdateCirculation. 2017;136:e137–e161. DOI: 10.1161/CIR.0000000000000509 August 8, 2017 e153CLINICAL STATEMENTS AND GUIDELINES 85. Ledwidge M, Gallagher J, Conlon C, et al. What was the STOP-HF random-ized trial?

Output: Natriuretic peptide-based screening and collaborative care for heart failure: the STOP-HF random-ized trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2017 ACC/AHA/HFSA Heart Failure Focused UpdateCirculation. 2017;136:e137–e161. DOI: 10.1161/CIR.0000000000000509 August 8, 2017 e153CLINICAL STATEMENTS AND GUIDELINES 85. Ledwidge M, Gallagher J, Conlon C, et al. What was the STOP-HF random-ized trial?. ### Response: Natriuretic peptide-based screening and collaborative care for heart failure: the STOP-HF random-ized trial.


Instruction: What does PONTIAC stand for?

Output: NT-proBNP selected prevention of cardiac events in a population of diabetic patients without a history of cardiac disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does PONTIAC stand for?. ### Response: NT-proBNP selected prevention of cardiac events in a population of diabetic patients without a history of cardiac disease.


Instruction: What is the name of the prospective randomized controlled trial?

Output: PONTIAC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective randomized controlled trial?. ### Response: PONTIAC.


Instruction: How many diabetic patients have a history of cardiac disease?

Output: 89

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many diabetic patients have a history of cardiac disease?. ### Response: 89.


Instruction: What is the name of the Valsartan Heart Failure Trial?

Output: Val-HeFT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Valsartan Heart Failure Trial?. ### Response: Val-HeFT.


Instruction: What does Val-HeFT stand for?

Output: Valsartan Heart Failure Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Val-HeFT stand for?. ### Response: Valsartan Heart Failure Trial.


Instruction: How does B-type natriuretic peptide pre-dict sudden death in patients with chronic heart failure?

Output: prediction of death at dif-ferent stages of the disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does B-type natriuretic peptide pre-dict sudden death in patients with chronic heart failure?. ### Response: prediction of death at dif-ferent stages of the disease.


Instruction: What does natriuretic peptide pre-dict in patients with chronic heart failure?

Output: sudden death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does natriuretic peptide pre-dict in patients with chronic heart failure?. ### Response: sudden death.


Instruction: When did Circulation. 2002:105:2392-7?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circulation. 2002:105:2392-7?. ### Response: 2003.


Instruction: What is the relationship between B-type natruri-uretic Peptides and pulmonary capillary wedge pressure in the intensive care unit?

Output: Relationship

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the relationship between B-type natruri-uretic Peptides and pulmonary capillary wedge pressure in the intensive care unit?. ### Response: Relationship.


Instruction: What are independent risk factors for morbidity and mortality in patients with congestive heart failure?

Output: uretic peptide and interleukin-6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are independent risk factors for morbidity and mortality in patients with congestive heart failure?. ### Response: uretic peptide and interleukin-6.


Instruction: What is the name of the study that found high levels of plasma brain natri-uretic peptide and interleukin-6?

Output: Rapid Emergency Department Heart Failure Outpatient Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that found high levels of plasma brain natri-uretic peptide and interleukin-6?. ### Response: Rapid Emergency Department Heart Failure Outpatient Trial.


Instruction: What is the name of the peptide used in the prediction of death at different stages of heart failure?

Output: B-type natriuretic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the peptide used in the prediction of death at different stages of heart failure?. ### Response: B-type natriuretic.


Instruction: When did the J Am Coll Cardiol. 2000 issue 36:1587–93?

Output: 2000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the J Am Coll Cardiol. 2000 issue 36:1587–93?. ### Response: 2000.


Instruction: What does N-terminal-pro-brain natri-uretic peptide predict after hospital discharge in heart failure?

Output: outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does N-terminal-pro-brain natri-uretic peptide predict after hospital discharge in heart failure?. ### Response: outcome.


Instruction: What is the name of the drug used to predict hemodynamic and clinical decompensation?

Output: B-type natriuretic peptide levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used to predict hemodynamic and clinical decompensation?. ### Response: B-type natriuretic peptide levels.


Instruction: How does natri-uretic peptide predict outcome after hospital discharge in heart failure patients?

Output: N-terminal-pro-brain

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does natri-uretic peptide predict outcome after hospital discharge in heart failure patients?. ### Response: N-terminal-pro-brain.


Instruction: What is the name of the study that predicts treatment outcomes in patients admitted for decompensated heart failure?

Output: a pilot study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that predicts treatment outcomes in patients admitted for decompensated heart failure?. ### Response: a pilot study.


Instruction: How did Cheng V, Kazanagra R, Garcia A, et al. determine treatment outcomes?

Output: A rapid bedside test

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Cheng V, Kazanagra R, Garcia A, et al. determine treatment outcomes?. ### Response: A rapid bedside test.


Instruction: What is used to predict in-hospital mortality from ADHERE?

Output: B-type natri-uretic peptide and cardiac troponin levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used to predict in-hospital mortality from ADHERE?. ### Response: B-type natri-uretic peptide and cardiac troponin levels.


Instruction: What is the name of the pilot study?

Output: PONTIAC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the pilot study?. ### Response: PONTIAC.


Instruction: When was the J Am Coll Cardiol.37:386-91?

Output: 2001

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol.37:386-91?. ### Response: 2001.


Instruction: What is the name of the rapid emergency department heart failure outpatient trial?

Output: REDHOT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the rapid emergency department heart failure outpatient trial?. ### Response: REDHOT.


Instruction: What type of peptide assay is used to identify patients at high risk of re-admission?

Output: B-type natriuretic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of peptide assay is used to identify patients at high risk of re-admission?. ### Response: B-type natriuretic.


Instruction: What is the acronym for Rapid Emergency Department Heart Failure Outpatient Trial?

Output: REDHOT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Rapid Emergency Department Heart Failure Outpatient Trial?. ### Response: REDHOT.


Instruction: What is REDHOT?

Output: Rapid Emergency Department Heart Failure Outpatient Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is REDHOT?. ### Response: Rapid Emergency Department Heart Failure Outpatient Trial.


Instruction: A multi-center study of what?

Output: B-type natriuretic peptide levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A multi-center study of what?. ### Response: B-type natriuretic peptide levels.


Instruction: What did Tribouilloy C, Rusinaru D, Szymanski C, et al. Predicting left ventricular dysfunction after valve repair for mitral regurgitation due to leaflet pro-lapse?

Output: additive value of left ventricular end-systolic dimension to ejection fraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Tribouilloy C, Rusinaru D, Szymanski C, et al. Predicting left ventricular dysfunction after valve repair for mitral regurgitation due to leaflet pro-lapse?. ### Response: additive value of left ventricular end-systolic dimension to ejection fraction.


Instruction: What did Additive value of leftventricular end-systolic dimension to ejection fraction do?

Output: Predicting left ventricular dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Additive value of leftventricular end-systolic dimension to ejection fraction do?. ### Response: Predicting left ventricular dysfunction.


Instruction: How long did EVEREST II last?

Output: 5-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did EVEREST II last?. ### Response: 5-year.


Instruction: What is the name of the study that compared percutaneous repair and surgery for mitral regurgitation?

Output: EVEREST II

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that compared percutaneous repair and surgery for mitral regurgitation?. ### Response: EVEREST II.


Instruction: What causes mitral regurgitation?

Output: leaflet pro-lapse

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes mitral regurgitation?. ### Response: leaflet pro-lapse.


Instruction: What is the current era of repair for “burnt-out” rheumatic disease?

Output: inferior

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the current era of repair for “burnt-out” rheumatic disease?. ### Response: inferior.


Instruction: When was the N Engl J Med.364:1395–406.

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the N Engl J Med.364:1395–406.. ### Response: 2011.


Instruction: What is the current era of degenerative disease?

Output: reconstructive surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the current era of degenerative disease?. ### Response: reconstructive surgery.


Instruction: What are the outcomes after repair of the anterior mitral leaflet for?

Output: degenerative disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the outcomes after repair of the anterior mitral leaflet for?. ### Response: degenerative disease.


Instruction: How did Gillinov AM, Blackstone EH, Alaulaqi A, et al. assess?

Output: Outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Gillinov AM, Blackstone EH, Alaulaqi A, et al. assess?. ### Response: Outcomes.


Instruction: What is the relationship between surgical volume, repair quality, and perioperative outcomes for repair of mitral in-sufficiency in a mitral valve reference center?

Output: repair rate, durability, and survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the relationship between surgical volume, repair quality, and perioperative outcomes for repair of mitral in-sufficiency in a mitral valve reference center?. ### Response: repair rate, durability, and survival.


Instruction: What was the J Thorac Cardiovasc Surg 2014;148:2021–6?

Output: mitral valve reference center

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the J Thorac Cardiovasc Surg 2014;148:2021–6?. ### Response: mitral valve reference center.


Instruction: Is there an outcome penalty linked to guideline-based indications for valvular surgery?

Output: an outcome pen-alty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Is there an outcome penalty linked to guideline-based indications for valvular surgery?. ### Response: an outcome pen-alty.


Instruction: Early and long-term analysis of patients with organic mitral regurgitation.

Output: Is there an outcome pen-alty linked to guideline-based indications for valvular surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Early and long-term analysis of patients with organic mitral regurgitation.. ### Response: Is there an outcome pen-alty linked to guideline-based indications for valvular surgery.


Instruction: What are the outcomes of mitral valve repair for degenerative disease with posterior, anterior, and bileaflet prolapse?

Output: A comparison

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the outcomes of mitral valve repair for degenerative disease with posterior, anterior, and bileaflet prolapse?. ### Response: A comparison.


Instruction: When did J Thorac Cardiovasc Surg. 2005;130:1242–9?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J Thorac Cardiovasc Surg. 2005;130:1242–9?. ### Response: 2015.


Instruction: What is the survival advantage and improved durability of withral repair?

Output: leaflet prolapse subsets in the current era

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the survival advantage and improved durability of withral repair?. ### Response: leaflet prolapse subsets in the current era.


Instruction: What is repairable in the modern era of reconstructive surgery?

Output: All anterior and bileaflet mitral valve prolapses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is repairable in the modern era of reconstructive surgery?. ### Response: All anterior and bileaflet mitral valve prolapses.


Instruction: What are all anterior and bileaflet mitral valve prolapses?

Output: repairable in the modern era of reconstructive surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are all anterior and bileaflet mitral valve prolapses?. ### Response: repairable in the modern era of reconstructive surgery.


Instruction: What is the repair rate for mitral valve prolapse?

Output: near 100%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the repair rate for mitral valve prolapse?. ### Response: near 100%.


Instruction: What is a near 100% repair rate achievable in a reference center?

Output: mitral valve prolapse

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a near 100% repair rate achievable in a reference center?. ### Response: mitral valve prolapse.


Instruction: In what year was the J Am Coll Cardiol 69:2397–406.

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was the J Am Coll Cardiol 69:2397–406.. ### Response: 2017.


Instruction: What is achievable in a reference center?

Output: A near 100% repair rate for mitral valve prolapse

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is achievable in a reference center?. ### Response: A near 100% repair rate for mitral valve prolapse.


Instruction: What is the time have come to define centers?

Output: centers of excellence in mitral valve repair

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the time have come to define centers?. ### Response: centers of excellence in mitral valve repair.


Instruction: What has come to define centers of excellence in mitral valve repair?

Output: The time

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has come to define centers of excellence in mitral valve repair?. ### Response: The time.


Instruction: What year did J Am Coll Cardiol.67:499–501?

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did J Am Coll Cardiol.67:499–501?. ### Response: 2016.


Instruction: What does the GRADE system use to assess the strength of each recommendation?

Output: the se four domains

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the GRADE system use to assess the strength of each recommendation?. ### Response: the se four domains.


Instruction: What are the se four domains used to assess?

Output: the strength of  each recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the se four domains used to assess?. ### Response: the strength of  each recommendation.


Instruction: What is the most commonly used exercise intensity range?

Output: 70% to 80% of peak V⋅o2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most commonly used exercise intensity range?. ### Response: 70% to 80% of peak V⋅o2.