Instruction: Where is rifampin used?

Output: staphylococcal IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is rifampin used?. ### Response: staphylococcal IE.


Instruction: What does rifampin do to staphylococcal IE?

Output: antibi-otic rifampin is included as an addition to other antibiotic drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does rifampin do to staphylococcal IE?. ### Response: antibi-otic rifampin is included as an addition to other antibiotic drugs.


Instruction: What is the mortality rate associated with prosthetic valve endocarditis?

Output: relatively high

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the mortality rate associated with prosthetic valve endocarditis?. ### Response: relatively high.


Instruction: What is the most common cause of valve endocarditis?

Output: S aureus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common cause of valve endocarditis?. ### Response: S aureus.


Instruction: What type of valve infection is most likely to be caused by S aureus?

Output: prosthetic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of valve infection is most likely to be caused by S aureus?. ### Response: prosthetic.


Instruction: How can pediatric IE be treated with medical management alone?

Output: patches or prostheses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can pediatric IE be treated with medical management alone?. ### Response: patches or prostheses.


Instruction: What is a risk factor for death for prosthetic valve infection caused by S aureus?

Output: independent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for death for prosthetic valve infection caused by S aureus?. ### Response: independent.


Instruction: What is not feasible?

Output: timely transfer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not feasible?. ### Response: timely transfer.


Instruction: What does an ACHD program have in addition to cardiac anesthesia?

Output: congenital cardiac surgery, and specialty cardiac imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does an ACHD program have in addition to cardiac anesthesia?. ### Response: congenital cardiac surgery, and specialty cardiac imaging.


Instruction: What is a direct renin inhibitor versusplacebo?

Output: Adults with CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a direct renin inhibitor versusplacebo?. ### Response: Adults with CKD.


Instruction: What is an aliskiren versus ACEi or ARBTable?

Output: ACEi DARB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an aliskiren versus ACEi or ARBTable?. ### Response: ACEi DARB.


Instruction: Adults with diabetes and CKD, high-dose potassium binder versus what?

Output: low-dosepotassium binder

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Adults with diabetes and CKD, high-dose potassium binder versus what?. ### Response: low-dosepotassium binder.


Instruction: What type of diet are kidney transplant recipients compared to?

Output: low-salt

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diet are kidney transplant recipients compared to?. ### Response: low-salt.


Instruction: What is the difference between a Mediterranean diet and a low-fat diet?

Output: Kidney transplant recipients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between a Mediterranean diet and a low-fat diet?. ### Response: Kidney transplant recipients.


Instruction: Kidney transplant recipients, ARB versus calcium channel blockersTable S94.

Output: ACEi

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Kidney transplant recipients, ARB versus calcium channel blockersTable S94.. ### Response: ACEi.


Instruction: What is ACEi versus ARBTable Table S95?

Output: ACEi Dcalcium channel blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ACEi versus ARBTable Table S95?. ### Response: ACEi Dcalcium channel blockers.


Instruction: What are kidney transplant recipients comparing to?

Output: low-salt diet versus usual or normal-salt dietTable S90. Kidney transplant recipients, Mediterranean diet versus low-fat diet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are kidney transplant recipients comparing to?. ### Response: low-salt diet versus usual or normal-salt dietTable S90. Kidney transplant recipients, Mediterranean diet versus low-fat diet.


Instruction: Channel blockers versus calcium channel blockers aloneTable S97.

Output: ACEi Dcalcium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Channel blockers versus calcium channel blockers aloneTable S97.. ### Response: ACEi Dcalcium.


Instruction: Kidney transplant recipients, ACEi DARB versus ARB alone Table S99.

Output: placebo or no treatmentTable S100

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Kidney transplant recipients, ACEi DARB versus ARB alone Table S99.. ### Response: placebo or no treatmentTable S100.


Instruction: What are kidney transplant recipients referred to as?

Output: ACE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are kidney transplant recipients referred to as?. ### Response: ACE.


Instruction: What is a kidney transplant recipient called?

Output: ACEi

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a kidney transplant recipient called?. ### Response: ACEi.


Instruction: What is ACEi versus?

Output: calcium channel blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ACEi versus?. ### Response: calcium channel blockers.


Instruction: What is ARB versus beta-blocker?

Output: calcium channel blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ARB versus beta-blocker?. ### Response: calcium channel blockers.


Instruction: Which kidney transplant recipients have calcium channel blockers versus thiazide?

Output: Kidney transplant recipients, calcium channel blockers versus thiazideTable S106

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which kidney transplant recipients have calcium channel blockers versus thiazide?. ### Response: Kidney transplant recipients, calcium channel blockers versus thiazideTable S106.


Instruction: What is the difference between channel blockers and thiazide?

Output: calcium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between channel blockers and thiazide?. ### Response: calcium.


Instruction: What are the differences between kidney transplant recipients and placebo?

Output: no treatment, or standard of care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the differences between kidney transplant recipients and placebo?. ### Response: no treatment, or standard of care.


Instruction: Where is Kidney International located?

Output: 2021) 99, S1–S87

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Kidney International located?. ### Response: 2021) 99, S1–S87.


Instruction: What percentage of patients underwent multivessel primary PCI during the indexhospitalization?

Output: 72%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients underwent multivessel primary PCI during the indexhospitalization?. ### Response: 72%.


Instruction: How long did the composite primary outcome of death, reinfarction, heart failure, and ischemia-driven revascularization occur in 15 patients?

Output: 12 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the composite primary outcome of death, reinfarction, heart failure, and ischemia-driven revascularization occur in 15 patients?. ### Response: 12 months.


Instruction: What is the third Danish Study of Optimal Acute Care?

Output: DANAMI 3 PRIMULTI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the third Danish Study of Optimal Acute Care?. ### Response: DANAMI 3 PRIMULTI.


Instruction: What is a PCI?

Output: percutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a PCI?. ### Response: percutaneous coronary intervention.


Instruction: What is the third Danish study of Optimal Acute Treatment ofPatients with ST-segment El evation Myocardial Infarc-tion called?

Output: DANAMI 3 PRIMULTI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the third Danish study of Optimal Acute Treatment ofPatients with ST-segment El evation Myocardial Infarc-tion called?. ### Response: DANAMI 3 PRIMULTI.


Instruction: What was the primary outcome of the DANAMI 3 PRIMULTI trial?

Output: a l l - c a u s ed e a t h ,n o n f a t a lM I , or ischemia-driven revas-cularization of nonculprit artery disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary outcome of the DANAMI 3 PRIMULTI trial?. ### Response: a l l - c a u s ed e a t h ,n o n f a t a lM I , or ischemia-driven revas-cularization of nonculprit artery disease.


Instruction: How many of 314 patients had ischemia-driven revascularization of nonculprit artery disease?

Output: 40

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many of 314 patients had ischemia-driven revascularization of nonculprit artery disease?. ### Response: 40.


Instruction: How many patients underwent multivessel stagedP C Ig u i d e db?

Output: 314

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients underwent multivessel stagedP C Ig u i d e db?. ### Response: 314.


Instruction: How many of 313 patients were treated with culprit artery only PCI?

Output: 68

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many of 313 patients were treated with culprit artery only PCI?. ### Response: 68.


Instruction: What was the HR of PRAGUE-13?

Output: 0.56

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the HR of PRAGUE-13?. ### Response: 0.56.


Instruction: How many patients in the STEMI trial were randomized to staged revascularization?

Output: 214

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients in the STEMI trial were randomized to staged revascularization?. ### Response: 214.


Instruction: How much diameter diameter were STEMI noninfarct lesions?

Output: $70%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much diameter diameter were STEMI noninfarct lesions?. ### Response: $70%.


Instruction: What was the median follow-up at 38 months?

Output: nobetween-group differences in the composite primaryendpoint of all-cause death, nonfatal MI, and stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the median follow-up at 38 months?. ### Response: nobetween-group differences in the composite primaryendpoint of all-cause death, nonfatal MI, and stroke.


Instruction: What type of PCI was used?

Output: culprit artery –only PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of PCI was used?. ### Response: culprit artery –only PCI.


Instruction: What was the primary endpoint of all-cause death, nonfatal MI, and stroke?

Output: 38 months ’mean follow-up

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary endpoint of all-cause death, nonfatal MI, and stroke?. ### Response: 38 months ’mean follow-up.


Instruction: How long was the mean follow-up?

Output: 38 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the mean follow-up?. ### Response: 38 months.


Instruction: Who recommended multi-vessel primary PCI?

Output: Modi

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who recommended multi-vessel primary PCI?. ### Response: Modi.


Instruction: What has been upgraded to a Class IIbrecommendation?

Output: STEMI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been upgraded to a Class IIbrecommendation?. ### Response: STEMI.


Instruction: What should not be interpreted as endorsingroutine performance?

Output: this change

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not be interpreted as endorsingroutine performance?. ### Response: this change.


Instruction: What should not be interpreted as endorsing theroutine performance of multivessel PCI in all patients with STEMI and multivenous disease?

Output: this change

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not be interpreted as endorsing theroutine performance of multivessel PCI in all patients with STEMI and multivenous disease?. ### Response: this change.


Instruction: What should physicians integrate when considering the indications for and timing ofmultivesselPCI?

Output: clinical data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should physicians integrate when considering the indications for and timing ofmultivesselPCI?. ### Response: clinical data.


Instruction: Which class of PCI shouldn't be performed in anoninfarct artery at all?

Output: Class III: Harm Class IIbPCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which class of PCI shouldn't be performed in anoninfarct artery at all?. ### Response: Class III: Harm Class IIbPCI.


Instruction: What class of PCI should not be performed in anoninfarct artery at thetime of primary PCI inpatients with STEMIwho arehemodynamicallystable?

Output: Class III: Harm Class IIbPCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What class of PCI should not be performed in anoninfarct artery at thetime of primary PCI inpatients with STEMIwho arehemodynamicallystable?. ### Response: Class III: Harm Class IIbPCI.


Instruction: What type of artery may beconsidered in selectedpatientswith STEMIand multivesseldisease who are hemodynamically stable?

Output: PCI of a noninfarctartery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of artery may beconsidered in selectedpatientswith STEMIand multivesseldisease who are hemodynamically stable?. ### Response: PCI of a noninfarctartery.


Instruction: What is PCIor as a planned stagedprocedure?

Output: multivesselPCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PCIor as a planned stagedprocedure?. ### Response: multivesselPCI.


Instruction: What class was changed from "III: Harm" to "IIb"and expanded timeframe in whichmultivessel PCI couldbe performed?

Output: Modiﬁedrecommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What class was changed from "III: Harm" to "IIb"and expanded timeframe in whichmultivessel PCI couldbe performed?. ### Response: Modiﬁedrecommendation.


Instruction: What did Meschia et al Guidelines for the Primary Prevention of Stroke 3789 reduce by an additional 20% to 25% com-pared with a lower dose?

Output: stroke and cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Meschia et al Guidelines for the Primary Prevention of Stroke 3789 reduce by an additional 20% to 25% com-pared with a lower dose?. ### Response: stroke and cardiovascular events.


Instruction: How many patients with the metabolic syndrome were randomly assigned to a study?

Output: 5584

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with the metabolic syndrome were randomly assigned to a study?. ### Response: 5584.


Instruction: How many patients with metabolic syndrome were randomly assigned to high- or low-dose statin?

Output: 5584

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with metabolic syndrome were randomly assigned to high- or low-dose statin?. ### Response: 5584.


Instruction: What did the higher dose of statin lead to greater reductions in at 3 months?

Output: LDL cholesterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the higher dose of statin lead to greater reductions in at 3 months?. ### Response: LDL cholesterol.


Instruction: How much more patients with the metabolic syndrome had a major cardio-vascular event than patients without metabolic syndrome?

Output: 11.3%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much more patients with the metabolic syndrome had a major cardio-vascular event than patients without metabolic syndrome?. ### Response: 11.3%).


Instruction: What percentage of patients with metabolic syndrome had a major cardio-vascular event than those without metabolic syndrome?

Output: 11.3%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients with metabolic syndrome had a major cardio-vascular event than those without metabolic syndrome?. ### Response: 11.3%).


Instruction: What was the median follow-up of patients receiving low-dose statin?

Output: 4.9 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the median follow-up of patients receiving low-dose statin?. ### Response: 4.9 years.


Instruction: How many patients receiving higher dose statin had major cardiovascular events?

Output: 9.5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients receiving higher dose statin had major cardiovascular events?. ### Response: 9.5%.


Instruction: What percentage of people receiving a higher dose of Metabolic Syndrome were at risk for ischemic stroke?

Output: 9.5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of people receiving a higher dose of Metabolic Syndrome were at risk for ischemic stroke?. ### Response: 9.5%.


Instruction: What was reduced by 26% of people who received the higher dose?

Output: cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was reduced by 26% of people who received the higher dose?. ### Response: cardiovascular events.


Instruction: Which component of the metabolic syndrome is associated with an increased risk of ischemia?

Output: alcohol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which component of the metabolic syndrome is associated with an increased risk of ischemia?. ### Response: alcohol.


Instruction: What is the risk of ischemic stroke and should be treated as appropriate?

Output: increased

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of ischemic stroke and should be treated as appropriate?. ### Response: increased.


Instruction: The specific risk of stroke in people with metabolic syndrome appears to be higher but remains uncertain?

Output: the effect of treatment of the syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The specific risk of stroke in people with metabolic syndrome appears to be higher but remains uncertain?. ### Response: the effect of treatment of the syndrome.


Instruction: What is recommended management of individual components of the meta-bolic syndrome?

Output: lifestyle measures (ie, exercise, appropriate weight loss, proper diet) and pharmacotherapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended management of individual components of the meta-bolic syndrome?. ### Response: lifestyle measures (ie, exercise, appropriate weight loss, proper diet) and pharmacotherapy.


Instruction: What is recommended of individual components of the metabolic syndrome?

Output: Management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended of individual components of the metabolic syndrome?. ### Response: Management.


Instruction: Lifestyle measures include what?

Output: exercise, appropriate weight loss, proper diet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Lifestyle measures include what?. ### Response: exercise, appropriate weight loss, proper diet.


Instruction: Pharmacotherapy includes medications for BP lowering, lipid lowering and what else?

Output: glycemic control, and antiplatelet therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Pharmacotherapy includes medications for BP lowering, lipid lowering and what else?. ### Response: glycemic control, and antiplatelet therapy.


Instruction: What does the National Institute on Alcohol Abuse and Alcoholism define heavy drinking for a man as?

Output: >4 drinks in any single day or >14 drinks per week

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the National Institute on Alcohol Abuse and Alcoholism define heavy drinking for a man as?. ### Response: >4 drinks in any single day or >14 drinks per week.


Instruction: How many drinks in a single day does the national institute on alcohol abuse and alcoholism say a woman must drink per week?

Output: >3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many drinks in a single day does the national institute on alcohol abuse and alcoholism say a woman must drink per week?. ### Response: >3.


Instruction: How many drinks per day does a woman drink?

Output: >3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many drinks per day does a woman drink?. ### Response: >3.


Instruction: What is a standard drink defined as?

Output: 12 fl oz of regular beer, 5 fl oz of table wine, or a 1.5–fl oz shot of 80-proof spirits

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a standard drink defined as?. ### Response: 12 fl oz of regular beer, 5 fl oz of table wine, or a 1.5–fl oz shot of 80-proof spirits.


Instruction: How many fl oz of regular beer is considered to be a normal drink for women?

Output: 12

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many fl oz of regular beer is considered to be a normal drink for women?. ### Response: 12.


Instruction: What can heavy alcohol consumption lead to?

Output: multiple medical

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can heavy alcohol consumption lead to?. ### Response: multiple medical.


Instruction: What is a risk factor for all types of stroke?

Output: Heavy alcohol consumption

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for all types of stroke?. ### Response: Heavy alcohol consumption.


Instruction: Most studies suggest a J-shaped association between alcohol consumption and the risk of total and ischemic stroke with what effect?

Output: a protective effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Most studies suggest a J-shaped association between alcohol consumption and the risk of total and ischemic stroke with what effect?. ### Response: a protective effect.


Instruction: What type of drinkers have a protective effect against total and ischemic stroke?

Output: light (<151 g/wk) or moderate (151 to 300 g/wk) drinkers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of drinkers have a protective effect against total and ischemic stroke?. ### Response: light (<151 g/wk) or moderate (151 to 300 g/wk) drinkers.


Instruction: What is the risk of ICH in heavy drinkers?

Output: (>300 g/wk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of ICH in heavy drinkers?. ### Response: (>300 g/wk.


Instruction: How many people were studied in a pro-spective cohort study?

Output: 540

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were studied in a pro-spective cohort study?. ### Response: 540.


Instruction: How many patients had spontaneous ICH?

Output: 540

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had spontaneous ICH?. ### Response: 540.


Instruction: What was associated with ICH at a young age?

Output: heavy alcohol intake

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with ICH at a young age?. ### Response: heavy alcohol intake.


Instruction: Alcohol consumption is associated with higher levels of what?

Output: HDL cholesterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Alcohol consumption is associated with higher levels of what?. ### Response: HDL cholesterol.


Instruction: Who published the 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease?

Output: Arnett et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease?. ### Response: Arnett et al.


Instruction: What is the name of the guideline that addresses major issues related to cholesterol management?

Output: Cholesterol Clinical Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the guideline that addresses major issues related to cholesterol management?. ### Response: Cholesterol Clinical Practice Guidelines.


Instruction: What are the major issues related to cholesterol management addressed in the 2018 Cholesterol Clinical Practice Guidelines?

Output: primary ASCVD prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the major issues related to cholesterol management addressed in the 2018 Cholesterol Clinical Practice Guidelines?. ### Response: primary ASCVD prevention.


Instruction: What does this writing committee agree for young adults?

Output: priority should be given to estimating lifetime risk and promoting a healthy lifestyle

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does this writing committee agree for young adults?. ### Response: priority should be given to estimating lifetime risk and promoting a healthy lifestyle.


Instruction: Who agrees that for young adults, prioritization should be given to estimating lifetime risk and promoting a healthy lifestyle?

Output: This writing committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who agrees that for young adults, prioritization should be given to estimating lifetime risk and promoting a healthy lifestyle?. ### Response: This writing committee.


Instruction: Only in select patients with mod-erately high LDL-C (160 mg/dL) is drug therapy indicated?

Output: interme-diate-risk patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Only in select patients with mod-erately high LDL-C (160 mg/dL) is drug therapy indicated?. ### Response: interme-diate-risk patients.


Instruction: How much LDL-C is drug therapy indicated for?

Output: low-density lipoprotein cholesterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much LDL-C is drug therapy indicated for?. ### Response: low-density lipoprotein cholesterol.


Instruction: What should guide therapeutic considerations in adults 40 to 75 years of age?

Output: 10-year ASCVD risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should guide therapeutic considerations in adults 40 to 75 years of age?. ### Response: 10-year ASCVD risk.


Instruction: The higher the estimated risk, the more likely the patient is to benefit from what?

Output: statin treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The higher the estimated risk, the more likely the patient is to benefit from what?. ### Response: statin treatment.


Instruction: What is needed to decide whether to continue or initiate statin treatment?

Output: assessment of risk status and a clinician pa-tient risk discussion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed to decide whether to continue or initiate statin treatment?. ### Response: assessment of risk status and a clinician pa-tient risk discussion.


Instruction: For a detailed discussion of statin safety, please refer to what section of the 2018 Cholesterol Clinical Manual?

Output: S4.3-1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For a detailed discussion of statin safety, please refer to what section of the 2018 Cholesterol Clinical Manual?. ### Response: S4.3-1.


Instruction: What is Section 5 of the 2018 Cholesterol Clinical Practice Guidelines?

Output: S4.3-1Recommendation-Specific Supportive Text

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Section 5 of the 2018 Cholesterol Clinical Practice Guidelines?. ### Response: S4.3-1Recommendation-Specific Supportive Text.


Instruction: Large-scale RCTs in primary prevention demonstrated ASCVD risk reduction with moder -ate-intensityS4.3-6,S4.3-36 and what else outweighed the observable risks?

Output: high-intensity statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Large-scale RCTs in primary prevention demonstrated ASCVD risk reduction with moder -ate-intensityS4.3-6,S4.3-36 and what else outweighed the observable risks?. ### Response: high-intensity statin therapy.


Instruction: What type of population confirmed statin benefit from a moderate-intensity statin therapy as compared with placebo in interme-diate-risk patients?

Output: eth-nically and racially diverse

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of population confirmed statin benefit from a moderate-intensity statin therapy as compared with placebo in interme-diate-risk patients?. ### Response: eth-nically and racially diverse.


Instruction: How old were the men enrolled in the RCT?

Output: ≥55 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old were the men enrolled in the RCT?. ### Response: ≥55 years of age.


Instruction: What were the women enrolled with at least 1 cardiovascular risk factor?

Output: ≥65 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the women enrolled with at least 1 cardiovascular risk factor?. ### Response: ≥65 years of age.


Instruction: What does ABI stand for?

Output: ankle-brachial index

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ABI stand for?. ### Response: ankle-brachial index.


Instruction: What does apoB stand for in relation to?

Output: apolipoprotein B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does apoB stand for in relation to?. ### Response: apolipoprotein B.


Instruction: In the placebo, what does hs-CRP mean?

Output: high-sensitivity C-reactive protein

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the placebo, what does hs-CRP mean?. ### Response: high-sensitivity C-reactive protein.


Instruction: How does LDL-C refer to cholesterol?

Output: low-density lipoprotein cholesterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does LDL-C refer to cholesterol?. ### Response: low-density lipoprotein cholesterol.


Instruction: What is high-sensitivity C-reactive protein?

Output: hs-CRP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is high-sensitivity C-reactive protein?. ### Response: hs-CRP.


Instruction: What is low-density lipoprotein cholesterol?

Output: LDL-C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is low-density lipoprotein cholesterol?. ### Response: LDL-C.


Instruction: What is the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Circulation. 2021;143:e72–e227

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Circulation. 2021;143:e72–e227.


Instruction: What are the recommendations summarized in in Online Data Supplement 15 to 17.

Output: Referenced studies that support the recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the recommendations summarized in in Online Data Supplement 15 to 17.. ### Response: Referenced studies that support the recommendations.


Instruction: What is indicated regardless of LV systolic function in symptomatic patients with severe AR?

Output: aortic valve surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is indicated regardless of LV systolic function in symptomatic patients with severe AR?. ### Response: aortic valve surgery.


Instruction: What is the LVEF 55% in Stage C2 patients?

Output: 60%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the LVEF 55% in Stage C2 patients?. ### Response: 60%).


Instruction: What percentage of LV systolic dysfunction is LVEF 55%)?

Output: 60%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of LV systolic dysfunction is LVEF 55%)?. ### Response: 60%).


Instruction: Aortic valve surgery is indicated if no other cause for what is identified?

Output: systolic dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Aortic valve surgery is indicated if no other cause for what is identified?. ### Response: systolic dysfunction.


Instruction: In patients with severe AR who are undergoing cardiac surgery for other indications, what is indicated?

Output: aortic valve surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with severe AR who are undergoing cardiac surgery for other indications, what is indicated?. ### Response: aortic valve surgery.


Instruction: What is indicated in asymptomatic patients with severe AR and normal LV systolic function?

Output: low surgical risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is indicated in asymptomatic patients with severe AR and normal LV systolic function?. ### Response: low surgical risk.


Instruction: What is reasonable when the LV is severely enlarged?

Output: aortic valve surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable when the LV is severely enlarged?. ### Response: aortic valve surgery.


Instruction: What type of surgery is reasonable in patients with moderate AR?

Output: aortic valve surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of surgery is reasonable in patients with moderate AR?. ### Response: aortic valve surgery.


Instruction: What is Stage B?

Output: moderate AR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Stage B?. ### Response: moderate AR.


Instruction: In asymptomatic patients with severe AR and normal LV systolic function at rest, what is LVEF >55%?

Output: Stage C1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In asymptomatic patients with severe AR and normal LV systolic function at rest, what is LVEF >55%?. ### Response: Stage C1.


Instruction: What percentage of LVEF is considered Stage C1?

Output: 55% to 60%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of LVEF is considered Stage C1?. ### Response: 55% to 60%).


Instruction: What is considered low surgical risk for aortic valve surgery?

Output: progressive decline in LVEF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is considered low surgical risk for aortic valve surgery?. ### Response: progressive decline in LVEF.


Instruction: How many serial studies have shown a progressive decline in LVF?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many serial studies have shown a progressive decline in LVF?. ### Response: 3.


Instruction: In patients with isolated severe AR who have indications for SAVR and are candidates for surgery, TAVI should not be performed what?

Output: 29–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with isolated severe AR who have indications for SAVR and are candidates for surgery, TAVI should not be performed what?. ### Response: 29–.


Instruction: What is the LV end-diastolic dimension (LVEDD) >65 mm?

Output: LV dilation into the severe range

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the LV end-diastolic dimension (LVEDD) >65 mm?. ### Response: LV dilation into the severe range.


Instruction: What do indications for surgery for chronic severe AR require?

Output: valve replacement with a mechani-cal or bioprosthetic valve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do indications for surgery for chronic severe AR require?. ### Response: valve replacement with a mechani-cal or bioprosthetic valve.


Instruction: What is preservation of the native aortic valve known as?

Output: valve sparing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is preservation of the native aortic valve known as?. ### Response: valve sparing.


Instruction: What are the current recommendations for AVR related to severity of LV dilation based on?

Output: mea-surement of LV short-axis diameters

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the current recommendations for AVR related to severity of LV dilation based on?. ### Response: mea-surement of LV short-axis diameters.


Instruction: What are advanc-es occurring in?

Output: primary aortic valve repair

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are advanc-es occurring in?. ### Response: primary aortic valve repair.


Instruction: What is the prognostic value of LV volume measurements in chronic AR using?

Output: >65 mm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the prognostic value of LV volume measurements in chronic AR using?. ### Response: >65 mm.


Instruction: What has been determined as have criteria for severe LV dilation?

Output: Normal limits for LV volumes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been determined as have criteria for severe LV dilation?. ### Response: Normal limits for LV volumes.


Instruction: How do the values for normal limits for LV volumes differ?

Output: these values differ between 2D echocardiography, 3D echocardiography, and CMR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do the values for normal limits for LV volumes differ?. ### Response: these values differ between 2D echocardiography, 3D echocardiography, and CMR.


Instruction: What is the difference between 2D and 3D echocardiography?

Output: Normal limits for LV volumes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between 2D and 3D echocardiography?. ### Response: Normal limits for LV volumes.


Instruction: What is there insufficient data on?

Output: LV volume measurements in chronic AR using left ventriculogra-phy,43 2D echocardiography,18,44 and CMR.45,46 Normal limits for LV volumes have been determined, as have criteria for severe LV dilation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is there insufficient data on?. ### Response: LV volume measurements in chronic AR using left ventriculogra-phy,43 2D echocardiography,18,44 and CMR.45,46 Normal limits for LV volumes have been determined, as have criteria for severe LV dilation.


Instruction: What is the standard for imaging dur -ing MR surgery?

Output: Intraoperative TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the standard for imaging dur -ing MR surgery?. ### Response: Intraoperative TEE.


Instruction: What may give the surgeon a better understanding of the valve before the operative incision?

Output: Three-dimensional TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may give the surgeon a better understanding of the valve before the operative incision?. ### Response: Three-dimensional TEE.


Instruction: What is a three-dimensional TEE?

Output: surgical view

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a three-dimensional TEE?. ### Response: surgical view.


Instruction: What does TEE mean?

Output: surgical view

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does TEE mean?. ### Response: surgical view.


Instruction: Why is TEE helpful?

Output: to evaluate the mitral valve apparatus and LV function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is TEE helpful?. ### Response: to evaluate the mitral valve apparatus and LV function.


Instruction: What should be evaluated at the same loading conditions as occurred during the awake state?

Output: deci-sions about severity of MR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be evaluated at the same loading conditions as occurred during the awake state?. ### Response: deci-sions about severity of MR.


Instruction: What is especially helpful in gauging the adequacy of repair?

Output: Intraoperative TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is especially helpful in gauging the adequacy of repair?. ### Response: Intraoperative TEE.


Instruction: What is particularly helpful in gauging the adequacy of repair?

Output: Intraoperative TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is particularly helpful in gauging the adequacy of repair?. ### Response: Intraoperative TEE.


Instruction: Because even mild residual MR after repair increases the likelihood of later repair failure, surgeons strive for near-perfect what?

Output: operative repair

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Because even mild residual MR after repair increases the likelihood of later repair failure, surgeons strive for near-perfect what?. ### Response: operative repair.


Instruction: Adequacy is judged by TEE after physiological filling pressure and blood pressure have been established?

Output: repair

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Adequacy is judged by TEE after physiological filling pressure and blood pressure have been established?. ### Response: repair.


Instruction: What can cause systolic anterior leaflet motion?

Output: underfilling of the LV

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can cause systolic anterior leaflet motion?. ### Response: underfilling of the LV.


Instruction: What can happen if more than trivial MR is detected after repair?

Output: repair revision usually ensues

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can happen if more than trivial MR is detected after repair?. ### Response: repair revision usually ensues.


Instruction: What is helpful in determining the feasibility of transcatheter edge-to-edge repair in patients with primary severe MR who are at high surgical risk?

Output: TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is helpful in determining the feasibility of transcatheter edge-to-edge repair in patients with primary severe MR who are at high surgical risk?. ### Response: TEE.


Instruction: What is indicated to evaluate the mitral valve apparatus in patients with primary MR?

Output: TTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is indicated to evaluate the mitral valve apparatus in patients with primary MR?. ### Response: TTE.


Instruction: What is the Online Data Supplement 26.COR LOE Recommendation1 B-NR1.

Output: Referenced studies that support the recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Online Data Supplement 26.COR LOE Recommendation1 B-NR1.. ### Response: Referenced studies that support the recommendation.


Instruction: What is TTE indicated to evaluate?

Output: mitral valve apparatus and LV function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is TTE indicated to evaluate?. ### Response: mitral valve apparatus and LV function.


Instruction: What provides clinical relevant information about patients who are being followed for primary MR who develop new-onset symptoms?

Output: A repeat TTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What provides clinical relevant information about patients who are being followed for primary MR who develop new-onset symptoms?. ### Response: A repeat TTE.


Instruction: What is the risk of MR Mild mitral valve prolapse with normal coaptation?

Output: Moderate to severe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of MR Mild mitral valve prolapse with normal coaptation?. ### Response: Moderate to severe.


Instruction: How much LA on Doppler is MR jet or small central jet area 20%?

Output: <20%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much LA on Doppler is MR jet or small central jet area 20%?. ### Response: <20%.


Instruction: Progressive MR Moderate to severe mitral venous prolapse?

Output: with normal coaptation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Progressive MR Moderate to severe mitral venous prolapse?. ### Response: with normal coaptation.


Instruction: What valve changes with leaflet restriction and loss of central coaptation can cause mitral valve prolapse?

Output: Rheumatic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What valve changes with leaflet restriction and loss of central coaptation can cause mitral valve prolapse?. ### Response: Rheumatic.


Instruction: What type of valve changes are most common?

Output: Rheumatic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of valve changes are most common?. ### Response: Rheumatic.


Instruction: How much LA enlargement is there?

Output: 1+ to 2+Mild

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much LA enlargement is there?. ### Response: 1+ to 2+Mild.


Instruction: What is the normal pulmonary pressure?

Output: NoneC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the normal pulmonary pressure?. ### Response: NoneC.


Instruction: Asymptomatic severe?

Output: NoneC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Asymptomatic severe?. ### Response: NoneC.


Instruction: What is the CHEST Grading System?

Output: Grade of Recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the CHEST Grading System?. ### Response: Grade of Recommendation.


Instruction: What does Bene fit clearly outweigh risk and burdens?

Output: High quality evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Bene fit clearly outweigh risk and burdens?. ### Response: High quality evidence.


Instruction: What can apply to most patients in most circumstances?

Output: Recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can apply to most patients in most circumstances?. ### Response: Recommendation.


Instruction: What is very unlikely to change our con fidence in theestimate of effect?

Output: Further research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is very unlikely to change our con fidence in theestimate of effect?. ### Response: Further research.


Instruction: What can have an important impact on our confidence in the estimate of effect?

Output: Higher quality research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can have an important impact on our confidence in the estimate of effect?. ### Response: Higher quality research.


Instruction: What is the con finiteness of the effectestimate?

Output: limited

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the con finiteness of the effectestimate?. ### Response: limited.


Instruction: What is likely to have an important impact on our confidence in the estimate of effect and may change the estimate?

Output: Higher quality research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is likely to have an important impact on our confidence in the estimate of effect and may change the estimate?. ### Response: Higher quality research.


Instruction: What clearly outweighs risk and burdens?

Output: Bene ﬁts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What clearly outweighs risk and burdens?. ### Response: Bene ﬁts.


Instruction: What is likely to be substantially different from the estimate ofeffect?

Output: The trueeffect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is likely to be substantially different from the estimate ofeffect?. ### Response: The trueeffect.


Instruction: Higher quality research has an important impact on ourconfidence in what?

Output: estimate of effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Higher quality research has an important impact on ourconfidence in what?. ### Response: estimate of effect.


Instruction: What fits closely balanced with risksand burden?

Output: High quality evidenceBene

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What fits closely balanced with risksand burden?. ### Response: High quality evidenceBene.


Instruction: What may differ depending oncircumstances or patients’ or societal values?

Output: Best action

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may differ depending oncircumstances or patients’ or societal values?. ### Response: Best action.


Instruction: What type of evidence fits closely balanced with risksand burden?

Output: High quality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of evidence fits closely balanced with risksand burden?. ### Response: High quality.


Instruction: What kind of effect is close to the estimate of the effect?

Output: true effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What kind of effect is close to the estimate of the effect?. ### Response: true effect.


Instruction: What may vary depending on circumstances or patients' or societal values?

Output: Best action

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may vary depending on circumstances or patients' or societal values?. ### Response: Best action.


Instruction: What may have animportant impact on our con fidence in theestimate of effect and may changetheestimate?

Output: Higher quality research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may have animportant impact on our con fidence in theestimate of effect and may changetheestimate?. ### Response: Higher quality research.


Instruction: What is the con fidence in the effectestimate?

Output: limited

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the con fidence in the effectestimate?. ### Response: limited.


Instruction: What may be substantiallydifferent from the estimate of the effect?

Output: The trueeffect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be substantiallydifferent from the estimate of the effect?. ### Response: The trueeffect.


Instruction: What is the prevalence of chronic heart failure in the United States?

Output: 90%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the prevalence of chronic heart failure in the United States?. ### Response: 90%,.


Instruction: What is a huge public health burden in the US?

Output: 90%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a huge public health burden in the US?. ### Response: 90%,.


Instruction: What prevents the development of HFL?

Output: Treatment of Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What prevents the development of HFL?. ### Response: Treatment of Hypertension.


Instruction: What has been shown to reduce the risk of HF?

Output: Treatment of Hypertension prevents the Development of HFLong-term treatment of both systolic and diastolic hyper-tension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been shown to reduce the risk of HF?. ### Response: Treatment of Hypertension prevents the Development of HFLong-term treatment of both systolic and diastolic hyper-tension.


Instruction: By 30% in younger populations, by 50% in the elderly, and by almost 80% in older populations?

Output: hypertension, the risk of developing HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: By 30% in younger populations, by 50% in the elderly, and by almost 80% in older populations?. ### Response: hypertension, the risk of developing HF.


Instruction: How much does optimal BP control decrease the risk of new HF?

Output: ≈50%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much does optimal BP control decrease the risk of new HF?. ### Response: ≈50%..


Instruction: What percentage of the elderly have a history of MI?

Output: 80%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the elderly have a history of MI?. ### Response: 80%.


Instruction: What was the risk of new HF by 50%?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk of new HF by 50%?. ### Response: ≈.


Instruction: What was reduced significantly by regimens based on angiotensin-converting enzyme inhibitors?

Output: the risk for develop-ing HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was reduced significantly by regimens based on angiotensin-converting enzyme inhibitors?. ### Response: the risk for develop-ing HF.


Instruction: What did ACE inhibitors not do?

Output: calcium antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did ACE inhibitors not do?. ### Response: calcium antagonists.


Instruction: What did treatment regimens that targeted lower BP goals produce?

Output: Greater risk reductions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did treatment regimens that targeted lower BP goals produce?. ### Response: Greater risk reductions.


Instruction: Hypertension to Prevent HFPatients with hypertension are at high risk for developing what?

Output: HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hypertension to Prevent HFPatients with hypertension are at high risk for developing what?. ### Response: HF.


Instruction: What should be controlled in accordance with contemporary guidelines to lower the risk of HF?

Output: hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be controlled in accordance with contemporary guidelines to lower the risk of HF?. ### Response: hypertension.


Instruction: What is the goal for treatment of high BP for patients who are 60 years of age or for adult pa-tients with chronic kidney disease or diabetes mellitus?

Output: <150/90 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the goal for treatment of high BP for patients who are 60 years of age or for adult pa-tients with chronic kidney disease or diabetes mellitus?. ### Response: <150/90 mm Hg.


Instruction: What are the 2014 evidence-based guidelines for the management of?

Output: high BP in adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the 2014 evidence-based guidelines for the management of?. ### Response: high BP in adults.


Instruction: What is the target for 150/90 mm Hg for patients 60 years of age in the general population?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the target for 150/90 mm Hg for patients 60 years of age in the general population?. ### Response: <.


Instruction: What has been debated and debated in the literature?

Output: this last recommendation of a higher target for patients ≥60 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been debated and debated in the literature?. ### Response: this last recommendation of a higher target for patients ≥60 years of age.


Instruction: What has been controversial and debated in the literature?

Output: this last recommendation of a higher target for patients ≥60 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been controversial and debated in the literature?. ### Response: this last recommendation of a higher target for patients ≥60 years of age.


Instruction: What is evidence that the initiation of an-tihypertensive treatment for the above thresholds is associated with?

Output: a reduction of HF and other cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is evidence that the initiation of an-tihypertensive treatment for the above thresholds is associated with?. ### Response: a reduction of HF and other cardiovascular events.


Instruction: How old are hyper-tensive patients with kidney disease or diabetes mellitus?

Output: ≥18 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old are hyper-tensive patients with kidney disease or diabetes mellitus?. ### Response: ≥18 years of age.


Instruction: What was a target of 140/90 mm Hg for the treatment of cardiovascular disease and stroke?

Output: <140/90 mm Hg for the treatment of Figure 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a target of 140/90 mm Hg for the treatment of cardiovascular disease and stroke?. ### Response: <140/90 mm Hg for the treatment of Figure 1.


Instruction: What is the general goal of 140/90 mm Hg for the treatment of Figure 1?

Output: AHA Guidelines for Primary Prevention of Cardiovascular Disease and Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the general goal of 140/90 mm Hg for the treatment of Figure 1?. ### Response: AHA Guidelines for Primary Prevention of Cardiovascular Disease and Stroke.


Instruction: Cumulative incidence of heart failure, adjusted for death as a competing risk, by baseline systolic blood pressure categories?

Output: <120, 120 to 139, 140 to 159, and ≥160 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cumulative incidence of heart failure, adjusted for death as a competing risk, by baseline systolic blood pressure categories?. ### Response: <120, 120 to 139, 140 to 159, and ≥160 mm Hg.


Instruction: What does Focused Update on Atrial FibrillationCirculation. 2019;140:e125–e151?

Output: January et al 2019

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Focused Update on Atrial FibrillationCirculation. 2019;140:e125–e151?. ### Response: January et al 2019.


Instruction: What is the DOI for Focuses Update on atrial fibrillation?

Output: 10.1161/CIR.0000000000000665

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the DOI for Focuses Update on atrial fibrillation?. ### Response: 10.1161/CIR.0000000000000665.


Instruction: What will be incor-porated into the full-text guideline in the future?

Output: Individual recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will be incor-porated into the full-text guideline in the future?. ### Response: Individual recommendations.


Instruction: What is the 2014 AF GuidelineS1.3-1?

Output: full-text version

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2014 AF GuidelineS1.3-1?. ### Response: full-text version.


Instruction: What does the LOE reflect when originally developed?

Output: COR/LOE system

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the LOE reflect when originally developed?. ### Response: COR/LOE system.


Instruction: What are LOE B and C?

Output: subcategorized for greater specificity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are LOE B and C?. ### Response: subcategorized for greater specificity.


Instruction: What is the latest COR/LOE system?

Output: LOE B and C are subcategorized for greater specificity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the latest COR/LOE system?. ### Response: LOE B and C are subcategorized for greater specificity.


Instruction: What are LOE B and C subcategorized for greater specificity?

Output: COR/LOE system

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are LOE B and C subcategorized for greater specificity?. ### Response: COR/LOE system.


Instruction: The section numbers correspond to what?

Output: full-text guideline sections

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The section numbers correspond to what?. ### Response: full-text guideline sections.


Instruction: Who reviewed data published in a peer-reviewed format through August 2018?

Output: the Task Force and members of the 2014 AF Guideline writ-ing group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who reviewed data published in a peer-reviewed format through August 2018?. ### Response: the Task Force and members of the 2014 AF Guideline writ-ing group.


Instruction: What did the Task Force and members of the 2014 AF Guideline writ-ing group do?

Output: to identify trials and other key data that might affect guideline recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Task Force and members of the 2014 AF Guideline writ-ing group do?. ### Response: to identify trials and other key data that might affect guideline recommendations.


Instruction: What is included in evidence tables in the Online Data Supplement?

Output: The infor -mation considered important enough to prompt up-dated recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is included in evidence tables in the Online Data Supplement?. ### Response: The infor -mation considered important enough to prompt up-dated recommendations.


Instruction: The complete section of recommendations for each clinical section is included to provide a comprehensive overview for what?

Output: the reader

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The complete section of recommendations for each clinical section is included to provide a comprehensive overview for what?. ### Response: the reader.


Instruction: What is included to provide a comprehensible overview for the reader?

Output: Rec-ommendations from the prior guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is included to provide a comprehensible overview for the reader?. ### Response: Rec-ommendations from the prior guideline.


Instruction: Recommendations that have been deleted or superseded are not what?

Output: incor -porated

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Recommendations that have been deleted or superseded are not what?. ### Response: incor -porated.


Instruction: What is provided to support the new and modified recommendations?

Output: The text

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is provided to support the new and modified recommendations?. ### Response: The text.


Instruction: What was appreciated that the primary author of the section had an RWI relevant to the section?

Output: After the preliminary recommendation and text were drafted for percutaneous approaches to occlusion of the left atrial appendage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was appreciated that the primary author of the section had an RWI relevant to the section?. ### Response: After the preliminary recommendation and text were drafted for percutaneous approaches to occlusion of the left atrial appendage.


Instruction: Task Force and organizational leadership directed that both the rec-ommendation and text be discarded and the section be constructed what?

Output: de novo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Task Force and organizational leadership directed that both the rec-ommendation and text be discarded and the section be constructed what?. ### Response: de novo.


Instruction: How was the new section constructed?

Output: de novo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the new section constructed?. ### Response: de novo.


Instruction: Who thoroughly reviewed this new section?

Output: the entire writing group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who thoroughly reviewed this new section?. ### Response: the entire writing group.


Instruction: What did the entire writing group do?

Output: thoroughly reviewed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the entire writing group do?. ### Response: thoroughly reviewed.


Instruction: What group formally voted on the recommendation?

Output: writing group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What group formally voted on the recommendation?. ### Response: writing group.


Instruction: What is COOLIST?

Output: Cooling for Ischemic Stroke Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is COOLIST?. ### Response: Cooling for Ischemic Stroke Trial.


Instruction: What is the name of the multicenter, open, randomized, phase ii, clinical trial?

Output: COOLIST

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multicenter, open, randomized, phase ii, clinical trial?. ### Response: COOLIST.


Instruction: What is Mild hypothermia after intravenous thromboly-sis in patients with acute stroke?

Output: a randomized controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Mild hypothermia after intravenous thromboly-sis in patients with acute stroke?. ### Response: a randomized controlled trial.


Instruction: What is the name of the randomized controlled trial?

Output: COOLIST

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized controlled trial?. ### Response: COOLIST.


Instruction: What is ICTuS-L?

Output: Intravenous Thrombolysis Plus Hypothermia for Acute Treatment of Ischemic Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ICTuS-L?. ### Response: Intravenous Thrombolysis Plus Hypothermia for Acute Treatment of Ischemic Stroke.


Instruction: What are the final results of the ICTus-L Investigators?

Output: 2265–2270

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the final results of the ICTus-L Investigators?. ### Response: 2265–2270.


Instruction: What is the TIMI II Pilot and Randomized Clinical Trial combined experience?

Output: Thrombolysis in Myocardial Infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the TIMI II Pilot and Randomized Clinical Trial combined experience?. ### Response: Thrombolysis in Myocardial Infarction.


Instruction: What is a common cause of intracerebral hemorrhage after rt-PA and heparin therapy?

Output: throm-bolysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a common cause of intracerebral hemorrhage after rt-PA and heparin therapy?. ### Response: throm-bolysis.


Instruction: What is the name of the Randomized Clinical Trial combined experience?

Output: Thrombolysis in Myocardial Infarction (TIMI) II Pilot

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Randomized Clinical Trial combined experience?. ### Response: Thrombolysis in Myocardial Infarction (TIMI) II Pilot.


Instruction: What was the result of the thrombolytic therapy for acute myocardial infarction?

Output: Neurosurgical evacuation of intracranial hemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the result of the thrombolytic therapy for acute myocardial infarction?. ### Response: Neurosurgical evacuation of intracranial hemorrhage.


Instruction: What is tPA?

Output: Global Utilization of Streptokinase and Tissue-Plasminogen Activator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is tPA?. ### Response: Global Utilization of Streptokinase and Tissue-Plasminogen Activator.


Instruction: What is the GUSTO-I trial used for?

Output: Global Utilization of Streptokinase and Tissue-Plasminogen Activator (tPA) for Occluded Coronary Arteries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the GUSTO-I trial used for?. ### Response: Global Utilization of Streptokinase and Tissue-Plasminogen Activator (tPA) for Occluded Coronary Arteries.


Instruction: When was the Am Heart J 138?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Am Heart J 138?. ### Response: 1999.


Instruction: What is a symptomatic intracerebral hemorrhage?

Output: throm-bolysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a symptomatic intracerebral hemorrhage?. ### Response: throm-bolysis.


Instruction: What is the name of the study that addresses the management of throm-bolysis-associated thrombolysis?

Output: COOLIST

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that addresses the management of throm-bolysis-associated thrombolysis?. ### Response: COOLIST.


Instruction: How many patients were treated with tranexamic acid?

Output: 141

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with tranexamic acid?. ### Response: 141.


Instruction: Who was treated with tissue plasminogen activator?

Output: Occluded Coronary Arteries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was treated with tissue plasminogen activator?. ### Response: Occluded Coronary Arteries.


Instruction: What does plasminogen activator do?

Output: a review of natural history and treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does plasminogen activator do?. ### Response: a review of natural history and treatment.


Instruction: What is the name of the drug used for thrombolysis in ischemic stroke?

Output: Intravenous Thrombolysis Plus Hypothermia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used for thrombolysis in ischemic stroke?. ### Response: Intravenous Thrombolysis Plus Hypothermia.


Instruction: When was the last time a patient had a stroke, what was it called?

Output: rombolysis Plus Hypothermia for Acute Treatment of Ischemic Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last time a patient had a stroke, what was it called?. ### Response: rombolysis Plus Hypothermia for Acute Treatment of Ischemic Stroke.


Instruction: What is recombi-nant factor VIIa used for in symptomatic intracerebral hemorrhage following intra-venous thrombolysis?

Output: 756

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recombi-nant factor VIIa used for in symptomatic intracerebral hemorrhage following intra-venous thrombolysis?. ### Response: 756.


Instruction: What is the doi: 10.4081/cp.2015.756144?

Output: Clin Pract. 2015;5:756

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the doi: 10.4081/cp.2015.756144?. ### Response: Clin Pract. 2015;5:756.


Instruction: What is a mul-ticenter retrospective study of thrombolysis-related hemorrhage?

Output: Treatment and outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a mul-ticenter retrospective study of thrombolysis-related hemorrhage?. ### Response: Treatment and outcome.


Instruction: What is the name of the study?

Output: Global Utilization of Streptokinase and Tissue-Plasminogen Activator (tPA) for Occluded Coronary Arteries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study?. ### Response: Global Utilization of Streptokinase and Tissue-Plasminogen Activator (tPA) for Occluded Coronary Arteries.


Instruction: How much of hypertension may be due to obesity?

Output: 40%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of hypertension may be due to obesity?. ### Response: 40%.


Instruction: What study showed that obesity may be responsible for 40% of the hypertension?

Output: Framingham Offspring Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What study showed that obesity may be responsible for 40% of the hypertension?. ### Response: Framingham Offspring Study.


Instruction: In what study did the Framingham Offspring Study show that obesity was responsible for even more than 40% of hypertensive?

Output: Nurses’ Health Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what study did the Framingham Offspring Study show that obesity was responsible for even more than 40% of hypertensive?. ### Response: Nurses’ Health Study.


Instruction: How is white coat effect detected in patients on drug therapy?

Output: Colors correspond to Class of Recommendation in Table 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is white coat effect detected in patients on drug therapy?. ### Response: Colors correspond to Class of Recommendation in Table 1.


Instruction: What is the class of recommendations in Table 1?

Output: Class of Recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the class of recommendations in Table 1?. ### Response: Class of Recommendation.


Instruction: What does ABPM stand for?

Output: ambulatory blood pressure monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ABPM stand for?. ### Response: ambulatory blood pressure monitoring.


Instruction: Where can HBPM be found?

Output: home blood pressure monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can HBPM be found?. ### Response: home blood pressure monitoring.


Instruction: What is the ACC/AHA guideline on the Primary Prevention of Cardiovascular Disease?

Output: 2019

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ACC/AHA guideline on the Primary Prevention of Cardiovascular Disease?. ### Response: 2019.


Instruction: What is recommended to maximize quit rates in adults who use tobacco?

Output: a combination of behavioral interventions plus pharmacotherapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended to maximize quit rates in adults who use tobacco?. ### Response: a combination of behavioral interventions plus pharmacotherapy.


Instruction: What is recommended in adults who use tobacco to reduce ASCVD risk?

Output: tobacco abstinence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended in adults who use tobacco to reduce ASCVD risk?. ### Response: tobacco abstinence.


Instruction: To facilitate tobacco cessation, it is reasonable to dedicate trained staff to tobacco treatment in every healthcare system.

Output: S4.5-4,S4.5-5IIa B-R5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: To facilitate tobacco cessation, it is reasonable to dedicate trained staff to tobacco treatment in every healthcare system.. ### Response: S4.5-4,S4.5-5IIa B-R5.


Instruction: What should all adults and adolescents avoid to reduce ASCVD risk?

Output: secondhand smoke exposure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should all adults and adolescents avoid to reduce ASCVD risk?. ### Response: secondhand smoke exposure.


Instruction: What is the leading preventable cause of disease, disability, and death in the United States?

Output: Tobacco use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the leading preventable cause of disease, disability, and death in the United States?. ### Response: Tobacco use.


Instruction: Smoking and smokeless tobacco use increases the risk of what?

Output: cardiovascular and pulmonary diseases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Smoking and smokeless tobacco use increases the risk of what?. ### Response: cardiovascular and pulmonary diseases.


Instruction: What is the risk of all-cause mortality?

Output: Smoking and smokeless tobacco

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of all-cause mortality?. ### Response: Smoking and smokeless tobacco.


Instruction: What is a cause of ASCVD and stroke?

Output: Secondhand smoke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a cause of ASCVD and stroke?. ### Response: Secondhand smoke.


Instruction: How much of CHD deaths are attributable to smoking and exposure to secondhand smoke?

Output: almost one-third

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of CHD deaths are attributable to smoking and exposure to secondhand smoke?. ### Response: almost one-third.


Instruction: What does reducing the number of cigarettes per day not completely eliminate?

Output: risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does reducing the number of cigarettes per day not completely eliminate?. ### Response: risk.


Instruction: Healthy People 2020 recommends that cessation treat-ment in clinical care settings be expanded?

Output: S4.5-8 Healthy People 2020 recommends that cessation treat-ment in clinical care settings be expanded, with access to proven cessation treatment provided to all tobacco users

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Healthy People 2020 recommends that cessation treat-ment in clinical care settings be expanded?. ### Response: S4.5-8 Healthy People 2020 recommends that cessation treat-ment in clinical care settings be expanded, with access to proven cessation treatment provided to all tobacco users.


Instruction: Electronic Nicotine Delivery Systems (ENDS) are often called what?

Output: e-cigarettes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Electronic Nicotine Delivery Systems (ENDS) are often called what?. ### Response: e-cigarettes.


Instruction: What are Electronic Nicotine Delivery Systems also known as?

Output: e-cigarettes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are Electronic Nicotine Delivery Systems also known as?. ### Response: e-cigarettes.


Instruction: What is a new class of tobacco product that emit aerosol containing fine and ultrafine particulates, nicotine, and toxic gases?

Output: Electronic Nicotine Delivery Systems (ENDS), often called e-cigarettes,S4.5-10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a new class of tobacco product that emit aerosol containing fine and ultrafine particulates, nicotine, and toxic gases?. ### Response: Electronic Nicotine Delivery Systems (ENDS), often called e-cigarettes,S4.5-10.


Instruction: Ar-rhythmias and hypertension with e-cigarette use have been reported with what?

Output: S4.5-11

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Ar-rhythmias and hypertension with e-cigarette use have been reported with what?. ### Response: S4.5-11.


Instruction: What is associated with persistent increases in oxidative stress and sympathetic stimulation in young, healthy subjects?

Output: Chronic use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with persistent increases in oxidative stress and sympathetic stimulation in young, healthy subjects?. ### Response: Chronic use.


Instruction: What is the US Public Health Service's Clinical Practice Guideline for Treating Tobacco Use and Dependence?

Output: S4.5-14,S4.5-15

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the US Public Health Service's Clinical Practice Guideline for Treating Tobacco Use and Dependence?. ### Response: S4.5-14,S4.5-15.


Instruction: In what year did the USPSTF rec-ommend (Grade A) that clinicians ask all adults about tobacco use?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did the USPSTF rec-ommend (Grade A) that clinicians ask all adults about tobacco use?. ### Response: 2003.


Instruction: What does recording tobacco use status in the health record increase?

Output: the rate of tobacco treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does recording tobacco use status in the health record increase?. ### Response: the rate of tobacco treatment.


Instruction: What does record at every healthcare visit increase?

Output: the rate of tobacco treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does record at every healthcare visit increase?. ### Response: the rate of tobacco treatment.


Instruction: What can facilitate tobacco cessation?

Output: Office-wide screen-ing systems

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can facilitate tobacco cessation?. ### Response: Office-wide screen-ing systems.


Instruction: How do clinicians assess tobacco use status?

Output: as a vital sign

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do clinicians assess tobacco use status?. ### Response: as a vital sign.


Instruction: Why do many people who use tobacco not report it?

Output: using multiple ques-tions to assess tobacco use status may improve accuracy and disclosure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why do many people who use tobacco not report it?. ### Response: using multiple ques-tions to assess tobacco use status may improve accuracy and disclosure.


Instruction: What percentage of patients with angiographicrestenosis present with symptomatic, clinically relevant reste-nosis at 1-year follow-up?

Output: Less than half

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients with angiographicrestenosis present with symptomatic, clinically relevant reste-nosis at 1-year follow-up?. ### Response: Less than half.


Instruction: How many patients from 6 trials of BMS had target-lesion revascu-larization?

Output: 6186

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients from 6 trials of BMS had target-lesion revascu-larization?. ### Response: 6186.


Instruction: How many patients from 6 trials of BMS showed target-lesion revascu-larization was performed?

Output: 6186

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients from 6 trials of BMS showed target-lesion revascu-larization was performed?. ### Response: 6186.


Instruction: What percentage of patients with clinicalrestenosis present with recurrent exertional angina?

Output: 842,843

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients with clinicalrestenosis present with recurrent exertional angina?. ### Response: 842,843.