Instruction: The risks of bleeding and throm-boembolism with mechanical prostheses are low, especially in compliant patients with appropriate INR monitoring.

Output: 14–19

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The risks of bleeding and throm-boembolism with mechanical prostheses are low, especially in compliant patients with appropriate INR monitoring.. ### Response: 14–19.


Instruction: What age group have studies shown a survival advantage with a mechanical prosthesis?

Output: between 50 and 65 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What age group have studies shown a survival advantage with a mechanical prosthesis?. ### Response: between 50 and 65 years of age.


Instruction: Large retrospec-tive observational studies have shown similar long-term survival rates in patients 50 to 69 years of age undergoing what type of valve replacement?

Output: mechanical versus biopros-thetic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Large retrospec-tive observational studies have shown similar long-term survival rates in patients 50 to 69 years of age undergoing what type of valve replacement?. ### Response: mechanical versus biopros-thetic.


Instruction: What is the difference between mechanical and bioprosthetic valve replacement?

Output: similar long-term survival rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between mechanical and bioprosthetic valve replacement?. ### Response: similar long-term survival rates.


Instruction: What causes a higher risk of bleeding in patients with mechanical valves?

Output: anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes a higher risk of bleeding in patients with mechanical valves?. ### Response: anticoagulation.


Instruction: Why do patients with biological valves experience a high rate of reoperation?

Output: structural deterioration of the prosthesis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why do patients with biological valves experience a high rate of reoperation?. ### Response: structural deterioration of the prosthesis.


Instruction: What are some other factors to consider in the choice of type of valve prosthesis?

Output: valve durability and risk of bleeding and thromboem-bolic events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some other factors to consider in the choice of type of valve prosthesis?. ### Response: valve durability and risk of bleeding and thromboem-bolic events.


Instruction: For all patients, but especially for those between 50 and 65 years of age, what is the choice?

Output: mechanical versus bio-prosthetic valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For all patients, but especially for those between 50 and 65 years of age, what is the choice?. ### Response: mechanical versus bio-prosthetic valve replacement.


Instruction: What is a shared decision-making process that must account for the trade-offs between dura-bility, bleeding, and thromboembolism?

Output: the choice of mechanical versus bio-prosthetic valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a shared decision-making process that must account for the trade-offs between dura-bility, bleeding, and thromboembolism?. ### Response: the choice of mechanical versus bio-prosthetic valve replacement.


Instruction: What is the likelihood of primary struc-tural deterioration at the time of bio-prosthetic AVR?

Output: 10%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the likelihood of primary struc-tural deterioration at the time of bio-prosthetic AVR?. ### Response: 10%..


Instruction: What is the likelihood of primary struc-tural deterioration at 15 to 20 years of age?

Output: 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the likelihood of primary struc-tural deterioration at 15 to 20 years of age?. ### Response: 50%.


Instruction: How much is the chance of a primary struc-tur deterioration at 15 or 20 years?

Output: 10%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much is the chance of a primary struc-tur deterioration at 15 or 20 years?. ### Response: 10%..


Instruction: What are older patients at higher risk of?

Output: bleeding caused by anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are older patients at higher risk of?. ### Response: bleeding caused by anticoagulation.


Instruction: What is less than significant under the preceding definition?

Output: Relationships that exist with no financial benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is less than significant under the preceding definition?. ### Response: Relationships that exist with no financial benefit.


Instruction: Relationships that exist with no financial benefit are also included for the purpose of what?

Output: transparency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Relationships that exist with no financial benefit are also included for the purpose of what?. ### Response: transparency.


Instruction: Names are listed in alphabetical order within each category of review.

Output: Relationships

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Names are listed in alphabetical order within each category of review.. ### Response: Relationships.


Instruction: Who did not provide a peer reviewer for this document?

Output: American College of Physicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who did not provide a peer reviewer for this document?. ### Response: American College of Physicians.


Instruction: What does ACC stand for?

Output: American College of Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ACC stand for?. ### Response: American College of Cardiology.


Instruction: Which category of review did the American College of Physicians not provide?

Output: peer reviewer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which category of review did the American College of Physicians not provide?. ### Response: peer reviewer.


Instruction: What is the acronym for American Stroke Association?

Output: ASA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for American Stroke Association?. ### Response: ASA.


Instruction: What is another acronym for Canadian Institutes of Health Research?

Output: CIHR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another acronym for Canadian Institutes of Health Research?. ### Response: CIHR.


Instruction: FH stands for what?

Output: familial hypercholesterolemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: FH stands for what?. ### Response: familial hypercholesterolemia.


Instruction: HFSA stands for Heart Failure Society of America.

Output: HFSA, Heart Failure Society of America; ISHLT, International Society for Heart and Lung Transplantation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: HFSA stands for Heart Failure Society of America.. ### Response: HFSA, Heart Failure Society of America; ISHLT, International Society for Heart and Lung Transplantation.


Instruction: ISHLT stands for International Society for Heart and Lung Transplantation.

Output: Institutes of Health Research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ISHLT stands for International Society for Heart and Lung Transplantation.. ### Response: Institutes of Health Research.


Instruction: What is the acronym for National Heart, Lung, and Blood Institute?

Output: NHLBI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for National Heart, Lung, and Blood Institute?. ### Response: NHLBI.


Instruction: What does PCORI stand for?

Output: Patient-Centered Outcomes Research Institute

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does PCORI stand for?. ### Response: Patient-Centered Outcomes Research Institute.


Instruction: Where does SCAI stand for Society for Cardiac Angiography and Interventions?

Output: Patient-Centered Outcomes Research Institute

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where does SCAI stand for Society for Cardiac Angiography and Interventions?. ### Response: Patient-Centered Outcomes Research Institute.


Instruction: What is the name of the agency that oversees veterans affairs?

Output: VA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the agency that oversees veterans affairs?. ### Response: VA.


Instruction: What state is the VA in charge of?

Output: UT, University of Texas

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What state is the VA in charge of?. ### Response: UT, University of Texas.


Instruction: On what date was the Appendix 2 downloaded?

Output: May 3, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On what date was the Appendix 2 downloaded?. ### Response: May 3, 2023.


Instruction: What is a standard process for properly screening all adults 18 years of age for HBP?

Output: CDU

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a standard process for properly screening all adults 18 years of age for HBP?. ### Response: CDU.


Instruction: What does USPSTF stand for?

Output: HBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does USPSTF stand for?. ### Response: HBP.


Instruction: What does the CDU use to properly screen all adults 18 years of age for HBP?

Output: a standard process/protocol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the CDU use to properly screen all adults 18 years of age for HBP?. ### Response: a standard process/protocol.


Instruction: What is the standard process/protocol for properly screening?

Output: daytime ABPM or HBPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the standard process/protocol for properly screening?. ### Response: daytime ABPM or HBPM.


Instruction: Adults ages 18-39 y with office-measured SBP/DBP 120/80 mm Hg can what?

Output: space out screenings to every 3–5 y

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Adults ages 18-39 y with office-measured SBP/DBP 120/80 mm Hg can what?. ### Response: space out screenings to every 3–5 y.


Instruction: What should be done for adults at increased risk for hypertension?

Output: Annual BP screening

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be done for adults at increased risk for hypertension?. ### Response: Annual BP screening.


Instruction: What should be confirmed at a follow-up visit within 1 month?

Output: the finding of an office BP consistent with hypertension and with SBP/DBP <160/100 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be confirmed at a follow-up visit within 1 month?. ### Response: the finding of an office BP consistent with hypertension and with SBP/DBP <160/100 mm Hg.


Instruction: How old are people who are overweight, obese or black?

Output: <40 y of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old are people who are overweight, obese or black?. ### Response: <40 y of age.


Instruction: How many BP measurements were taken at each follow-up visit?

Output: ≥2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many BP measurements were taken at each follow-up visit?. ### Response: ≥2.


Instruction: What is the 2017 Hypertension Clinical Practice Guidelines Recommendation4?

Output: In adults with an untreated SBP >130 mm Hg but <160 mm Hg or DBP >80 mm Hg but <100 mm Hg, it is reasonable to screen for the presence of white-coat hypertension by using either daytime ABPM or HBPM before diagnosis of hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2017 Hypertension Clinical Practice Guidelines Recommendation4?. ### Response: In adults with an untreated SBP >130 mm Hg but <160 mm Hg or DBP >80 mm Hg but <100 mm Hg, it is reasonable to screen for the presence of white-coat hypertension by using either daytime ABPM or HBPM before diagnosis of hypertension.


Instruction: What should be used to screen for the presence of white-coat hypertension?

Output: daytime ABPM or HBPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be used to screen for the presence of white-coat hypertension?. ### Response: daytime ABPM or HBPM.


Instruction: What is the class 2a, Level of Evidence: B-NR?

Output: 61–68

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the class 2a, Level of Evidence: B-NR?. ### Response: 61–68.


Instruction: In adults with untreated office BPs, what should be done?

Output: screening for masked hypertension with HBPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In adults with untreated office BPs, what should be done?. ### Response: screening for masked hypertension with HBPM.


Instruction: What type of hypertension is screening for with HBPM or ABPM reasonable in adults with untreated office BPs?

Output: masked

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of hypertension is screening for with HBPM or ABPM reasonable in adults with untreated office BPs?. ### Response: masked.


Instruction: What is HBPM or ABPM?

Output: masked hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is HBPM or ABPM?. ### Response: masked hypertension.


Instruction: What is the class of evidence for screening for HBP?

Output: Class 2a

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the class of evidence for screening for HBP?. ### Response: Class 2a.


Instruction: When did the USPSTF reaffirm its recommendation to screen for hypertension in adults 18 y of age?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the USPSTF reaffirm its recommendation to screen for hypertension in adults 18 y of age?. ### Response: 2003.


Instruction: What is Grade A recommendation?

Output: screen for hypertension in adults ≥18 y of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Grade A recommendation?. ### Response: screen for hypertension in adults ≥18 y of age.


Instruction: Who commissioned previous evidence reviews that screening for hypertension has few major harms and provides substantial benefits?

Output: USPSTF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who commissioned previous evidence reviews that screening for hypertension has few major harms and provides substantial benefits?. ### Response: USPSTF.


Instruction: What did these reviews not address?

Output: diagnostic accuracy of different BP measurement protocols

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did these reviews not address?. ### Response: diagnostic accuracy of different BP measurement protocols.


Instruction: What did the USPSTF examine for the present recommendation?

Output: the diagnostic accuracy of office BP measurement, ABPM, and HBPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the USPSTF examine for the present recommendation?. ### Response: the diagnostic accuracy of office BP measurement, ABPM, and HBPM.


Instruction: What did it assess for the diagnostic accuracy of office BP measurement?

Output: average of ≥2 BP measurements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did it assess for the diagnostic accuracy of office BP measurement?. ### Response: average of ≥2 BP measurements.


Instruction: What did the USPSTF review for optimal screening intervals for diagnosing hypertension in adults?

Output: 3–5 y

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the USPSTF review for optimal screening intervals for diagnosing hypertension in adults?. ### Response: 3–5 y.


Instruction: What found good evidence that screening for and treatment of HBP has few major harms?

Output: The USPSTF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What found good evidence that screening for and treatment of HBP has few major harms?. ### Response: The USPSTF.


Instruction: Who concluded with high certainty that the net benefit of screening for HBP in adults was net benefit?

Output: The USPSTF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who concluded with high certainty that the net benefit of screening for HBP in adults was net benefit?. ### Response: The USPSTF.


Instruction: What is the net benefit of screening for HBP in adults?

Output: substantial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the net benefit of screening for HBP in adults?. ### Response: substantial.


Instruction: Who randomly assigned patients to different rescreening intervals?

Output: No clinical trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who randomly assigned patients to different rescreening intervals?. ### Response: No clinical trials.


Instruction: What is lacking in RCT data targeting eitheroscillometric or auscultatory BP measurements in children?

Output: HBPM toimprove clinical outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is lacking in RCT data targeting eitheroscillometric or auscultatory BP measurements in children?. ### Response: HBPM toimprove clinical outcomes.


Instruction: What is the initial BP measurement in a clinic setting using?

Output: oscillometric using a calibrated machine that has beenvalidated for use in the pediatric population

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the initial BP measurement in a clinic setting using?. ### Response: oscillometric using a calibrated machine that has beenvalidated for use in the pediatric population.


Instruction: What is dif ficult to convert from oscillometric to ascultatory measurement on an individual basis?

Output: BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is dif ficult to convert from oscillometric to ascultatory measurement on an individual basis?. ### Response: BP.


Instruction: What should be con firmed by auscultation in individuals at particularly high risk for elevated BP?

Output: 364readings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be con firmed by auscultation in individuals at particularly high risk for elevated BP?. ### Response: 364readings.


Instruction: What has not been endorsed for the diagnosis of hypertension by the AAP Clinical Practice Guideline?

Output: Use of HBPM in children

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has not been endorsed for the diagnosis of hypertension by the AAP Clinical Practice Guideline?. ### Response: Use of HBPM in children.


Instruction: What have been clinicallyvalidated in children?

Output: elec-tronic upper-arm cuff monitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have been clinicallyvalidated in children?. ### Response: elec-tronic upper-arm cuff monitors.


Instruction: Where can the Validation status for oscillometric BP devices be checked?

Output: stridebp.org

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can the Validation status for oscillometric BP devices be checked?. ### Response: stridebp.org.


Instruction: What can be checked at stridebp.org?

Output: Validation status for oscillometric BP devices in thepediatric age group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be checked at stridebp.org?. ### Response: Validation status for oscillometric BP devices in thepediatric age group.


Instruction: How many days should H B P M be performed?

Output: 7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many days should H B P M be performed?. ### Response: 7.


Instruction: What should be performed for 7 days?

Output: H B P M

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be performed for 7 days?. ### Response: H B P M.


Instruction: How many readings per week have been suggested for children with suspected hypertension?

Output: 12

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many readings per week have been suggested for children with suspected hypertension?. ### Response: 12.


Instruction: What are the advantages of HBPM?

Output: the ability to obtain multiple BP measure-ments outside the of ﬁce setting, its relative ease of use, andperhaps higher acceptance by patients and families

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the advantages of HBPM?. ### Response: the ability to obtain multiple BP measure-ments outside the of ﬁce setting, its relative ease of use, andperhaps higher acceptance by patients and families.


Instruction: What is the relative ease of use of standardized of fice BP measurements?

Output: HBPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the relative ease of use of standardized of fice BP measurements?. ### Response: HBPM.


Instruction: No prospective RCTs targeting HBPM are available in children?

Output: improve clinical outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No prospective RCTs targeting HBPM are available in children?. ### Response: improve clinical outcomes.


Instruction: What is not available in children?

Output: Reliablefactors converting standardized of ﬁce BP to home BP orABPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not available in children?. ### Response: Reliablefactors converting standardized of ﬁce BP to home BP orABPM.


Instruction: What is needed to validate newer, more automated BP devices?

Output: clin-ical

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed to validate newer, more automated BP devices?. ### Response: clin-ical.


Instruction: The quality of the evidence is low for what outcomes?

Output: annual GFR loss and ESKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The quality of the evidence is low for what outcomes?. ### Response: annual GFR loss and ESKD.


Instruction: How was the quality of the evidence for the mortality outcome?

Output: low

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the quality of the evidence for the mortality outcome?. ### Response: low.


Instruction: What was the target of 50th percentile MAP by ABPM inchildren based on?

Output: a single RCT with study limitations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the target of 50th percentile MAP by ABPM inchildren based on?. ### Response: a single RCT with study limitations.


Instruction: Why was BP low?

Output: recom-mendation of a target of <50th percentile MAP by ABPM inchildren was based on a single RCT with study limitations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was BP low?. ### Response: recom-mendation of a target of <50th percentile MAP by ABPM inchildren was based on a single RCT with study limitations.


Instruction: Why is death a rare event in children?

Output: ations and very serious imprecision

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is death a rare event in children?. ### Response: ations and very serious imprecision.


Instruction: What has consistently shown bene fitsof BP lowering?

Output: multiple smaller interven-tional trials and observational studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has consistently shown bene fitsof BP lowering?. ### Response: multiple smaller interven-tional trials and observational studies.


Instruction: What are MAP targets at 90thpercentile bene ficial for children with glomerular ornon-glomerular causes of CKD?

Output: MAP targets at <90thpercentile are bene ﬁcial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are MAP targets at 90thpercentile bene ficial for children with glomerular ornon-glomerular causes of CKD?. ### Response: MAP targets at <90thpercentile are bene ﬁcial.


Instruction: What may have an additional bene fit?

Output: lower MAP at <50thpercentile

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may have an additional bene fit?. ### Response: lower MAP at <50thpercentile.


Instruction: What does the ACHD GuidelineCirculation. 2019:139:e698–e800?

Output: Stout et al 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the ACHD GuidelineCirculation. 2019:139:e698–e800?. ### Response: Stout et al 2018.


Instruction: What do the writing commit-tee use in developing recommendations?

Output: systematic review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do the writing commit-tee use in developing recommendations?. ### Response: systematic review.


Instruction: What is an RCT?

Output: randomized controlled trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an RCT?. ### Response: randomized controlled trials.


Instruction: What are RCTs also called?

Output: randomized controlled trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are RCTs also called?. ### Response: randomized controlled trials.


Instruction: What type of review will determine which patients are most likely to benefit from a drug, device, or treatment strategy?

Output: systematic review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of review will determine which patients are most likely to benefit from a drug, device, or treatment strategy?. ### Response: systematic review.


Instruction: What are the criteria for commissioning an ERC and formal systematic review?

Output: the absence of a current authoritative systematic review, b) the feasibility of defining the ben-efit and risk in a time frame

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the criteria for commissioning an ERC and formal systematic review?. ### Response: the absence of a current authoritative systematic review, b) the feasibility of defining the ben-efit and risk in a time frame.


Instruction: ERC and formal systematic review include: a) the absence of a current authoritative systematic review; b) the feasibility of defining the ben-efit and risk in a time frame consistent with the writing of what?

Output: a guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ERC and formal systematic review include: a) the absence of a current authoritative systematic review; b) the feasibility of defining the ben-efit and risk in a time frame consistent with the writing of what?. ### Response: a guideline.


Instruction: What do ERC members include?

Output: methodologists, epidemiologists, healthcare providers, and biostatisticians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do ERC members include?. ### Response: methodologists, epidemiologists, healthcare providers, and biostatisticians.


Instruction: What are the recommendations developed by the writing committee on the basis of the systematic review marked with?

Output: SR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the recommendations developed by the writing committee on the basis of the systematic review marked with?. ### Response: SR.


Instruction: The term Guideline-Directed Management and Therapy refers to what?

Output: clinical evaluation, diagnostic testing, and pharmacological and procedural treat-ments

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The term Guideline-Directed Management and Therapy refers to what?. ### Response: clinical evaluation, diagnostic testing, and pharmacological and procedural treat-ments.


Instruction: What is the term for guideline-directed management and therapy?

Output: GDMT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for guideline-directed management and therapy?. ### Response: GDMT.


Instruction: What does GDMT encompass?

Output: clinical evaluation, diagnostic testing, and pharmacological and procedural treat-ments

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does GDMT encompass?. ### Response: clinical evaluation, diagnostic testing, and pharmacological and procedural treat-ments.


Instruction: How should the reader confirm the dosage?

Output: by reviewing product insert material and evaluate the treatment regimen for contraindications and interac-tions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How should the reader confirm the dosage?. ### Response: by reviewing product insert material and evaluate the treatment regimen for contraindications and interac-tions.


Instruction: What does COR stand for?

Output: Class of Recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does COR stand for?. ### Response: Class of Recommendation.


Instruction: What is a class of recommendation?

Output: COR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a class of recommendation?. ### Response: COR.


Instruction: What indicates the strength of the recommendation?

Output: The Class of Recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates the strength of the recommendation?. ### Response: The Class of Recommendation.


Instruction: What measures the magnitude and certainty of benefit in propor tion to risk?

Output: The Class of Recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What measures the magnitude and certainty of benefit in propor tion to risk?. ### Response: The Class of Recommendation.


Instruction: The Level of Evidence (LOE) rates the quality of scientific evidence that supports the intervention on the basis of what?

Output: type, quantity, and consistency of data from clinical trials and other sources

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The Level of Evidence (LOE) rates the quality of scientific evidence that supports the intervention on the basis of what?. ### Response: type, quantity, and consistency of data from clinical trials and other sources.


Instruction: How are the recommendations listed in this guideline based?

Output: evidence-based

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are the recommendations listed in this guideline based?. ### Response: evidence-based.


Instruction: What is the name of the person who is a member of the ACC/AHA Task Force on Clinical Practice Guidelines?

Output: Glenn N. Levine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the person who is a member of the ACC/AHA Task Force on Clinical Practice Guidelines?. ### Response: Glenn N. Levine.


Instruction: What was included in the initial exten-sive evidence review?

Output: literature de-rived from research involving human subjects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was included in the initial exten-sive evidence review?. ### Response: literature de-rived from research involving human subjects.


Instruction: In what language was the initial review published?

Output: English

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what language was the initial review published?. ### Response: English.


Instruction: What is MEDLINE indexed in?

Output: PubMed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is MEDLINE indexed in?. ### Response: PubMed.


Instruction: Where is EMBASE indexed?

Output: MEDLINE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is EMBASE indexed?. ### Response: MEDLINE.


Instruction: Powers et al 2019 Guidelines for Management of AIS e405 81.

Output: Zaidi SF, Shawver J, Espinosa Morales A, Salahuddin H, Tietjen G,  Lindstrom D, Parquette B, Adams A, Korsnack A, Jumaa MA. Stroke  care: initial data from a county-based bypass protocol for patients with acute stroke. J Neurointerv Surg. 2017;9:631–635. doi: 10.1136/ neurintsurg-2016-012476 82

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Powers et al 2019 Guidelines for Management of AIS e405 81.. ### Response: Zaidi SF, Shawver J, Espinosa Morales A, Salahuddin H, Tietjen G,  Lindstrom D, Parquette B, Adams A, Korsnack A, Jumaa MA. Stroke  care: initial data from a county-based bypass protocol for patients with acute stroke. J Neurointerv Surg. 2017;9:631–635. doi: 10.1136/ neurintsurg-2016-012476 82.


Instruction: Zaidi SF, Shawver J, Espinosa Morales A, Salahuddin H, Tietjen G, Lindstrom D, Parquette B, Adams A, Korsnack A, Jumaa MA. What is the initial data from a county-based bypass protocol for patients with acute stroke?

Output: Stroke  care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Zaidi SF, Shawver J, Espinosa Morales A, Salahuddin H, Tietjen G, Lindstrom D, Parquette B, Adams A, Korsnack A, Jumaa MA. What is the initial data from a county-based bypass protocol for patients with acute stroke?. ### Response: Stroke  care.


Instruction: What is the name of the county-based bypass protocol for patients with acute stroke?

Output: 2016-012476 82

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the county-based bypass protocol for patients with acute stroke?. ### Response: 2016-012476 82.


Instruction: Magnetic res-onance imaging and computed tomography are used in emergency assessment of patients with what condition?

Output: suspected acute stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Magnetic res-onance imaging and computed tomography are used in emergency assessment of patients with what condition?. ### Response: suspected acute stroke.


Instruction: What is a prospective comparison of imaging and computed tomography in emergency assessment of patients with suspected acute stroke?

Output: Magnetic res-onance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a prospective comparison of imaging and computed tomography in emergency assessment of patients with suspected acute stroke?. ### Response: Magnetic res-onance.


Instruction: What is the name of the study group that studies imaging of the brain in acute ischaemic stroke.

Output: ASPECTS Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study group that studies imaging of the brain in acute ischaemic stroke.. ### Response: ASPECTS Study Group.


Instruction: What is the name of the study group that compares computed tomography and magnetic resonance diffusion-weighted imaging?

Output: ASPECTS Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study group that compares computed tomography and magnetic resonance diffusion-weighted imaging?. ### Response: ASPECTS Study Group.


Instruction: When was the J Neurol Neurosurg Psychiatry 76:1528-1533?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Neurol Neurosurg Psychiatry 76:1528-1533?. ### Response: 2005.


Instruction: What was the name of the Task Force on Performance Measures and Practice Guidelines?

Output: American College of Cardiology/American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the Task Force on Performance Measures and Practice Guidelines?. ### Response: American College of Cardiology/American Heart Association.


Instruction: What is the doi number for Circulation. 2014?

Output: 10.1161/CIR.0000000000000042 85

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the doi number for Circulation. 2014?. ### Response: 10.1161/CIR.0000000000000042 85.


Instruction: How does immediate computed tomography scan of acute stroke improve quality of life?

Output: cost-ef-fective

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does immediate computed tomography scan of acute stroke improve quality of life?. ### Response: cost-ef-fective.


Instruction: What year did Stroke. 2004:35:2477–2483. doi: 10.1161/01.STR.0000143453.78005.44?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Stroke. 2004:35:2477–2483. doi: 10.1161/01.STR.0000143453.78005.44?. ### Response: 2004.


Instruction: What is a comparison of MRI and CT for detection of acute intracerebral hemorrhage?

Output: computed tomography and magnetic resonance diffusion-weighted imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a comparison of MRI and CT for detection of acute intracerebral hemorrhage?. ### Response: computed tomography and magnetic resonance diffusion-weighted imaging.


Instruction: When did JAMA issue 292:1823-1830?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did JAMA issue 292:1823-1830?. ### Response: 2004.


Instruction: What is the doi number for JAMA?

Output: 10.1001/jama.292.15.1823

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the doi number for JAMA?. ### Response: 10.1001/jama.292.15.1823.


Instruction: What is accurate in hyperacute intracerebral hemorrhage?

Output: Stroke magnetic resonance im-aging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is accurate in hyperacute intracerebral hemorrhage?. ### Response: Stroke magnetic resonance im-aging.


Instruction: What is a multicenter study on the validity of stroke imaging?

Output: Stroke magnetic resonance im-aging is accurate in hyperacute intracerebral hemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a multicenter study on the validity of stroke imaging?. ### Response: Stroke magnetic resonance im-aging is accurate in hyperacute intracerebral hemorrhage.


Instruction: What is MRI-guided thrombolysis for stroke with unknown time of onset?

Output: WAKE-UP Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is MRI-guided thrombolysis for stroke with unknown time of onset?. ### Response: WAKE-UP Investigators.


Instruction: What is the doi: 10.1056/NEJMoa1804355?

Output: N Engl J Med. 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the doi: 10.1056/NEJMoa1804355?. ### Response: N Engl J Med. 2018.


Instruction: What is the N Engl J Med 2018 379:611–622 doi: 10.1056/NEJMoa1804355 89?

Output: MRI-guided thrombolysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the N Engl J Med 2018 379:611–622 doi: 10.1056/NEJMoa1804355 89?. ### Response: MRI-guided thrombolysis.


Instruction: What are the clinical relevance of microbleeds in acute stroke thrombolysis: comprehensive meta-analysis?

Output: International META-MICROBLEEDS Initiative

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the clinical relevance of microbleeds in acute stroke thrombolysis: comprehensive meta-analysis?. ### Response: International META-MICROBLEEDS Initiative.


Instruction: What are the 2019 AHA/ACC High Blood Pressure Performance and Quality Measures for Adults with high blood pressure?

Output: Cardiovasc Qual Outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the 2019 AHA/ACC High Blood Pressure Performance and Quality Measures for Adults with high blood pressure?. ### Response: Cardiovasc Qual Outcomes.


Instruction: What is the DOI: 10.1161/HCQ.0000000000000057 November 2019?

Output: Casey et al; 2019 AHA/ACC High Blood Pressure Performance and Quality MeasuresCirc Cardiovasc Qual Outcomes. 2019;12:e000057

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the DOI: 10.1161/HCQ.0000000000000057 November 2019?. ### Response: Casey et al; 2019 AHA/ACC High Blood Pressure Performance and Quality MeasuresCirc Cardiovasc Qual Outcomes. 2019;12:e000057.


Instruction: Who is the official TFPM Lead?

Output: Biykem Bozkurt

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the official TFPM Lead?. ### Response: Biykem Bozkurt.


Instruction: What is the title of Michael E. DeBakey VA Medical Center, Cardiology?

Output: —Chief, Cardiology Section

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of Michael E. DeBakey VA Medical Center, Cardiology?. ### Response: —Chief, Cardiology Section.


Instruction: What is Michael E. DeBakey VA Medical Center, Cardiology?

Output: —Chief, Cardiology Section

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Michael E. DeBakey VA Medical Center, Cardiology?. ### Response: —Chief, Cardiology Section.


Instruction: Who is the Chief of the Cardiology Section at ACC Medical College of Wisconsin?

Output: Michael E. DeBakey

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Chief of the Cardiology Section at ACC Medical College of Wisconsin?. ### Response: Michael E. DeBakey.


Instruction: What is the name of the company that produces Respicardia?

Output: Lantheus Medical Imaging, Inc• LivaNova USA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the company that produces Respicardia?. ### Response: Lantheus Medical Imaging, Inc• LivaNova USA.


Instruction: Who is the official AHA Medical University of South Carolina, Charleston (MUSC)Professor of Medicine and Pharmacology?

Output: Brent Egan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the official AHA Medical University of South Carolina, Charleston (MUSC)Professor of Medicine and Pharmacology?. ### Response: Brent Egan.


Instruction: What is the name of the official ACC Indiana University Health Director?

Output: Andrea L. Price

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the official ACC Indiana University Health Director?. ### Response: Andrea L. Price.


Instruction: What is the name of the professor, chair, and Chief of Hypertension Specialty Services at Southern Illinois University School of Medicine?

Output: John M. Flack

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor, chair, and Chief of Hypertension Specialty Services at Southern Illinois University School of Medicine?. ### Response: John M. Flack.


Instruction: Who is the Professor of Medicine at Mayo Clinic?

Output: Sandra J. Taler

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Professor of Medicine at Mayo Clinic?. ### Response: Sandra J. Taler.


Instruction: Who is the AHA Mayo Clinic Professor of Medicine?

Output: Sandra J. Taler

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the AHA Mayo Clinic Professor of Medicine?. ### Response: Sandra J. Taler.


Instruction: What is the name of the Vice President of the AMA American Medical Association?

Output: Michael Rakotz

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Vice President of the AMA American Medical Association?. ### Response: Michael Rakotz.


Instruction: Where is Cheryl Dennison-Himmelfarb from?

Output: Johns Hopkins School of Nursing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Cheryl Dennison-Himmelfarb from?. ### Response: Johns Hopkins School of Nursing.


Instruction: Who is Sarah E. Allison Endowed Professor and Deputy Director, Institute for Clinical Translational Research?

Output: Cheryl Dennison-Himmelfarb

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Sarah E. Allison Endowed Professor and Deputy Director, Institute for Clinical Translational Research?. ### Response: Cheryl Dennison-Himmelfarb.


Instruction: Who is Helene Fuld Health Trust?

Output: *• NIH*• PCNA† None

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Helene Fuld Health Trust?. ### Response: *• NIH*• PCNA† None.


Instruction: What was the name of the Firefighter who developed an arrhythmia at work?

Output: Marjorie L. King

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the Firefighter who developed an arrhythmia at work?. ### Response: Marjorie L. King.


Instruction: What is the title of the Professorship for Asian Health at the University of Washington School of Medicine?

Output: Medical Director and Clinical Associate Professor of Medicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of the Professorship for Asian Health at the University of Washington School of Medicine?. ### Response: Medical Director and Clinical Associate Professor of Medicine.


Instruction: What was the name of the Firefighter who developed an arrhythmia at work in 2017?

Output: Marjorie L. King

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the Firefighter who developed an arrhythmia at work in 2017?. ### Response: Marjorie L. King.


Instruction: Who was the Chief Medical Officer, Internal Medicine (Cardiology) and Director, Cardiopulmonary, Rehabilitation?

Output: Helen Hayes Hospital

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the Chief Medical Officer, Internal Medicine (Cardiology) and Director, Cardiopulmonary, Rehabilitation?. ### Response: Helen Hayes Hospital.


Instruction: How much radiation did CAC deliver?

Output: 0.74 to l.27 mSv

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much radiation did CAC deliver?. ### Response: 0.74 to l.27 mSv.


Instruction: What is the dose of a clinical mammogram similar to?

Output: 0.74 to l.27 mSv of radiation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the dose of a clinical mammogram similar to?. ### Response: 0.74 to l.27 mSv of radiation.


Instruction: Who should order CAC scans?

Output: a clinician who is fully versed in the pros and cons of diagnostic radiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should order CAC scans?. ### Response: a clinician who is fully versed in the pros and cons of diagnostic radiology.


Instruction: How many mmol/L of LDL-C are recommended for Adults 40 to 75 years of age?

Output: 1.7 to 4.8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mmol/L of LDL-C are recommended for Adults 40 to 75 years of age?. ### Response: 1.7 to 4.8.


Instruction: Where are studies that support recommendations summarized?

Output: Online Data Supplement 16.COR LOE RecommendationsI A1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are studies that support recommendations summarized?. ### Response: Online Data Supplement 16.COR LOE RecommendationsI A1.


Instruction: What does statin therapy reduce the risk of in adults at intermediate-risk?

Output: ASCVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does statin therapy reduce the risk of in adults at intermediate-risk?. ### Response: ASCVD.


Instruction: What should be recommended if a decision is made for statin?

Output: a moderate-intensity statin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be recommended if a decision is made for statin?. ### Response: a moderate-intensity statin.


Instruction: Where are references to studies summarized?

Output: Online Data Supplement 16.COR LOE RecommendationsI A1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are references to studies summarized?. ### Response: Online Data Supplement 16.COR LOE RecommendationsI A1.


Instruction: What type of statin should be used?

Output: moderate-intensity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of statin should be used?. ### Response: moderate-intensity.


Instruction: What should LDL-C levels be reduced by in intermediate-risk patients?

Output: 30% or more

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should LDL-C levels be reduced by in intermediate-risk patients?. ### Response: 30% or more.


Instruction: For optimal ASCVD risk reduction, levels should be decreased by what percentage or more?

Output: 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For optimal ASCVD risk reduction, levels should be decreased by what percentage or more?. ### Response: 50%.


Instruction: What is the primary prevention of clinical ASCVD in adults 40 to 75 years of age without diabetes mellitus and with an LDL-C level of 70 to 189 mg/dL?

Output: S4.4.2-1,S4.4.2-4–S4.4.2-9I B-NR3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary prevention of clinical ASCVD in adults 40 to 75 years of age without diabetes mellitus and with an LDL-C level of 70 to 189 mg/dL?. ### Response: S4.4.2-1,S4.4.2-4–S4.4.2-9I B-NR3.


Instruction: How long does it take to prevent a first “hard” asCVD event (fatal and nonfatal MI or stroke)?

Output: 10-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take to prevent a first “hard” asCVD event (fatal and nonfatal MI or stroke)?. ### Response: 10-year.


Instruction: What should be estimated by using the race- and sex-specific PCE?

Output: the 10-year ASCVD risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be estimated by using the race- and sex-specific PCE?. ### Response: the 10-year ASCVD risk.


Instruction: What should adults be categorized as being at low risk (5%), borderline risk (5% to 7.5%), intermediate-risk (7.5%to 20%)?

Output: intermediate-risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should adults be categorized as being at low risk (5%), borderline risk (5% to 7.5%), intermediate-risk (7.5%to 20%)?. ### Response: intermediate-risk.


Instruction: How should clinicians and patients engage with ASCVD?

Output: a risk discussion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How should clinicians and patients engage with ASCVD?. ### Response: a risk discussion.


Instruction: What percentage of patients are at risk for ASCVD?

Output: 1.7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients are at risk for ASCVD?. ### Response: 1.7.


Instruction: What should clinicians and patients consider for a individualized treatment decision?

Output: patient preferences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should clinicians and patients consider for a individualized treatment decision?. ### Response: patient preferences.


Instruction: What are patient preferences for?

Output: an individualized treatment decision

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patient preferences for?. ### Response: an individualized treatment decision.


Instruction: What do risk-enhancing factors favor in intermediate-risk adults?

Output: initiation or intensification of statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do risk-enhancing factors favor in intermediate-risk adults?. ### Response: initiation or intensification of statin therapy.


Instruction: How is it reasonable to use a CAC score in the decision to use statin?

Output: moderate-intensity statin should be recommended

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is it reasonable to use a CAC score in the decision to use statin?. ### Response: moderate-intensity statin should be recommended.


Instruction: What is reasonable to use a CAC score in the decision to withhold, postpone or initiate statin therapy?

Output: if the decision about statin use remains uncertain

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable to use a CAC score in the decision to withhold, postpone or initiate statin therapy?. ### Response: if the decision about statin use remains uncertain.


Instruction: In intermediate-risk adults, what is measured for the purpose of making a treatment decision?

Output: CAC score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In intermediate-risk adults, what is measured for the purpose of making a treatment decision?. ### Response: CAC score.


Instruction: If the coronary calcium score is zero, it is reasonable to withhold statin therapy and reassess in how many years?

Output: 5 to 10 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: If the coronary calcium score is zero, it is reasonable to withhold statin therapy and reassess in how many years?. ### Response: 5 to 10 years.


Instruction: If the CAC score is 1 to 99, what is it reasonable to do?

Output: initiate statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: If the CAC score is 1 to 99, what is it reasonable to do?. ### Response: initiate statin therapy.


Instruction: When is it reasonable to initiate statin therapy for patients 55 years of age?

Output: If CAC score is 1 to 99

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is it reasonable to initiate statin therapy for patients 55 years of age?. ### Response: If CAC score is 1 to 99.


Instruction: If CAC score is 100 or higher or in the 75th percentile or higher, it is reasonable to begin what?

Output: statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: If CAC score is 100 or higher or in the 75th percentile or higher, it is reasonable to begin what?. ### Response: statin therapy.


Instruction: How many participants were in the 33 cohorts?

Output: 310,000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many participants were in the 33 cohorts?. ### Response: 310,000.


Instruction: What is the name of the collaboration that studies body mass index and cardiovascular disease in the Asia-Pacific region?

Output: Asia Pacific Cohort Studies Collaboration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the collaboration that studies body mass index and cardiovascular disease in the Asia-Pacific region?. ### Response: Asia Pacific Cohort Studies Collaboration.


Instruction: What is body mass index and risk of stroke among Chinese men and women?

Output: Body mass index, waist circumference, and waist-hip ratio

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is body mass index and risk of stroke among Chinese men and women?. ### Response: Body mass index, waist circumference, and waist-hip ratio.


Instruction: What is the doi: 10.1093/ije/dyh163 286?

Output: Asia Pacific Cohort Studies Collaboration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the doi: 10.1093/ije/dyh163 286?. ### Response: Asia Pacific Cohort Studies Collaboration.


Instruction: What is the waist circumference and waist-hip ratio on the risk of total and type-specific stroke?

Output: Body mass index

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the waist circumference and waist-hip ratio on the risk of total and type-specific stroke?. ### Response: Body mass index.


Instruction: What was the name of the 2007 issue of Arch Intern Med?

Output: 167:1420–1427

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the 2007 issue of Arch Intern Med?. ### Response: 167:1420–1427.


Instruction: Who is Kurth T?

Output: Gaz

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Kurth T?. ### Response: Gaz.


Instruction: What is the risk of stroke in men?

Output: Body mass index

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of stroke in men?. ### Response: Body mass index.


Instruction: What is a prospective study of body mass index and stroke risk?

Output: Asia Pacific Cohort Studies Collaboration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a prospective study of body mass index and stroke risk?. ### Response: Asia Pacific Cohort Studies Collaboration.


Instruction: What is the name of the prospective study of body mass index and risk of stroke in apparently healthy women?

Output: Million Women Study Collaborators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective study of body mass index and risk of stroke in apparently healthy women?. ### Response: Million Women Study Collaborators.


Instruction: When did Circulation. 2005,111:1992–1998. doi: 10.1161/01.CIR.0000161822.83163.B6 290?

Output: 1998

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circulation. 2005,111:1992–1998. doi: 10.1161/01.CIR.0000161822.83163.B6 290?. ### Response: 1998.


Instruction: What does adiposity and ischemic and hemorrhagic stroke do?

Output: prospective study in women and meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does adiposity and ischemic and hemorrhagic stroke do?. ### Response: prospective study in women and meta-analysis.


Instruction: What is the name of the collaboration that studies adiposity and ischemic and hemorrhagic stroke?

Output: Million Women Study Collaborators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the collaboration that studies adiposity and ischemic and hemorrhagic stroke?. ### Response: Million Women Study Collaborators.


Instruction: What is BMI Mediated Effects?

Output: Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is BMI Mediated Effects?. ### Response: Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration.


Instruction: How many participants were in the pooled analysis of 97 prospective cohorts with 18 million participants?

Output: 310,000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many participants were in the pooled analysis of 97 prospective cohorts with 18 million participants?. ### Response: 310,000.


Instruction: What is the name of the study that looked at the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke?

Output: Metabolic mediators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that looked at the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke?. ### Response: Metabolic mediators.


Instruction: What is the name of the study that investigated the cardiovascular effects of intensive lifestyle intervention in type 2 diabetes?

Output: N Engl J Med.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the cardiovascular effects of intensive lifestyle intervention in type 2 diabetes?. ### Response: N Engl J Med..


Instruction: What was the N Engl J Med 2013 369:145–154?

Output: Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the N Engl J Med 2013 369:145–154?. ### Response: Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes.


Instruction: What is the name of the medical journal that studies bariatric surgery and long-term cardiovascular events?

Output: JAMA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the medical journal that studies bariatric surgery and long-term cardiovascular events?. ### Response: JAMA.


Instruction: When was the journal published?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the journal published?. ### Response: 2002.


Instruction: What was the title of the journal in 2012?

Output: JAMA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the title of the journal in 2012?. ### Response: JAMA.


Instruction: What is the association between bariatric surgery and macrovascular disease outcomes in patients with type 2 diabetes and severe obesity?

Output: long-term cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association between bariatric surgery and macrovascular disease outcomes in patients with type 2 diabetes and severe obesity?. ### Response: long-term cardiovascular events.


Instruction: What is JAMA. 2018;320:1570-1582. doi: 10.1001/jama.2018.14619 295?

Output: Association between bariatric surgery and macrovascular disease outcomes in patients with type 2 diabetes and severe obesity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is JAMA. 2018;320:1570-1582. doi: 10.1001/jama.2018.14619 295?. ### Response: Association between bariatric surgery and macrovascular disease outcomes in patients with type 2 diabetes and severe obesity.


Instruction: Inzucchi SE, Sawan C, Macko RF, Furie KL. Obesity: a stub-bornly obvious target for what?

Output: stroke prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Inzucchi SE, Sawan C, Macko RF, Furie KL. Obesity: a stub-bornly obvious target for what?. ### Response: stroke prevention.


Instruction: Stroke. 2013;44:278–286. doi: 10.1161/STROKEAHA.111.639922 296.

Output: Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Stroke. 2013;44:278–286. doi: 10.1161/STROKEAHA.111.639922 296.. ### Response: Stroke.


Instruction: What is NICE 2018?

Output: Monitoring  Chronic Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE 2018?. ### Response: Monitoring  Chronic Heart Failure.


Instruction: What are the Outcomes No of Participants (studies) Follow up Quality of evidence?

Output: Relative effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Outcomes No of Participants (studies) Follow up Quality of evidence?. ### Response: Relative effect.


Instruction: Relative effect (95% CI) Anticipated absolute effects Risk with Usual care Risk difference with structured telephone support (95% confidence interval) Better indicated by higher imprecisio n 4.6 (0.12 to 0.48 higher) Adherence to intervention (take medication)

Output: All-cause mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Relative effect (95% CI) Anticipated absolute effects Risk with Usual care Risk difference with structured telephone support (95% confidence interval) Better indicated by higher imprecisio n 4.6 (0.12 to 0.48 higher) Adherence to intervention (take medication). ### Response: All-cause mortality.


Instruction: Adherence to intervention (take medication) Better indicated by higher 287 (1 study) 3 months  LOW1 due to risk of bias What was the mean adherence to intervention in the control groups?

Output: 4.9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Adherence to intervention (take medication) Better indicated by higher 287 (1 study) 3 months  LOW1 due to risk of bias What was the mean adherence to intervention in the control groups?. ### Response: 4.9.


Instruction: How much higher was the mean adherence to intervention in the intervention groups?

Output: 0.1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much higher was the mean adherence to intervention in the intervention groups?. ### Response: 0.1.


Instruction: How many studies were involved in Community All-cause mortality?

Output: 9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were involved in Community All-cause mortality?. ### Response: 9.


Instruction: What was the reason for the LOW2,3?

Output: imprecision

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the reason for the LOW2,3?. ### Response: imprecision.


Instruction: Why was the publication bias 0.88?

Output: imprecision

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the publication bias 0.88?. ### Response: imprecision.


Instruction: What is the RR of publication bias due to imprecision, publication bias?

Output: 0.81

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the RR of publication bias due to imprecision, publication bias?. ### Response: 0.81.


Instruction: How many studies were carried out?

Output: 4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were carried out?. ### Response: 4.


Instruction: What was the LOW2,3 due to?

Output: imprecision, publication bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the LOW2,3 due to?. ### Response: imprecision, publication bias.


Instruction: Why are months  LOW2,3 due to imprecision, publication bias RR 0.81 (0.73 to 0.89) 498 per 1000 76 fewer per 1000 (from 44 fewer to 107 fewer) What is better indicated by lower 2103?

Output: Quality of life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why are months  LOW2,3 due to imprecision, publication bias RR 0.81 (0.73 to 0.89) 498 per 1000 76 fewer per 1000 (from 44 fewer to 107 fewer) What is better indicated by lower 2103?. ### Response: Quality of life.


Instruction: What was the mean QoL in the intervention groups?

Output: 4.28 lower

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean QoL in the intervention groups?. ### Response: 4.28 lower.


Instruction: What was better indicated by lower 2103 (4 studies) 3 to 24 months  HIGH 4?

Output: Quality of life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was better indicated by lower 2103 (4 studies) 3 to 24 months  HIGH 4?. ### Response: Quality of life.


Instruction: How long was the mean QoL in the control groups?

Output: 1.03

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the mean QoL in the control groups?. ### Response: 1.03.


Instruction: What is the term for life that is better indicated by lower 52 (1 study) 3 months  VERY LOW1,2 due to the risk of bias, imprecision?

Output: HDS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for life that is better indicated by lower 52 (1 study) 3 months  VERY LOW1,2 due to the risk of bias, imprecision?. ### Response: HDS.


Instruction: How much lower is the mean quality of life in the intervention groups (1.97)?

Output: 0.25

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much lower is the mean quality of life in the intervention groups (1.97)?. ### Response: 0.25.


Instruction: How much lower was the QoL in the intervention groups?

Output: 4.28

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much lower was the QoL in the intervention groups?. ### Response: 4.28.


Instruction: What was the Mixed All-cause mortality?

Output: 254

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the Mixed All-cause mortality?. ### Response: 254.


Instruction: How much higher was the RR?

Output: 1.32

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much higher was the RR?. ### Response: 1.32.


Instruction: What is the name of the randomised controlled trial conducted in France?

Output: The WALPA Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised controlled trial conducted in France?. ### Response: The WALPA Group.


Instruction: What group was involved in the trial?

Output: SPRINT Research Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What group was involved in the trial?. ### Response: SPRINT Research Group.


Instruction: In what year did the WALPA Group conduct a study?

Output: 1995

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did the WALPA Group conduct a study?. ### Response: 1995.


Instruction: Which group did Law MR, Morris JK, Wald NJ, and Wald NJ work together?

Output: WALPA Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which group did Law MR, Morris JK, Wald NJ, and Wald NJ work together?. ### Response: WALPA Group.


Instruction: Pressure lowering drugs in the prevention of cardiovascular disease: a meta-analysis of 147 randomised trials in the context of expectations from what?

Output: prospective epidemiological studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Pressure lowering drugs in the prevention of cardiovascular disease: a meta-analysis of 147 randomised trials in the context of expectations from what?. ### Response: prospective epidemiological studies.


Instruction: BMJ. 2009;338:b1665. S4.4-31. Ettehad D, Emdin CA, Kiran A, et al.

Output: Lancet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: BMJ. 2009;338:b1665. S4.4-31. Ettehad D, Emdin CA, Kiran A, et al.. ### Response: Lancet.


Instruction: What is a systematic review and meta-analysis of cardiovascular disease and death?

Output: Blood pressure lowering for prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a systematic review and meta-analysis of cardiovascular disease and death?. ### Response: Blood pressure lowering for prevention.


Instruction: What is the name of the systematic review in the Lancet in 2016?

Output: Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. Lancet. 2016;387:957–67

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review in the Lancet in 2016?. ### Response: Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. Lancet. 2016;387:957–67.


Instruction: In what year did the Ann Intern Med issue 162:184–91?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did the Ann Intern Med issue 162:184–91?. ### Response: 2015.


Instruction: Atkins E, Lv J, et al. Effects of intensive blood pressure low-ering on cardiovascular and renal outcomes: updated systematic review and meta-analysis.

Output: Xie X

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atkins E, Lv J, et al. Effects of intensive blood pressure low-ering on cardiovascular and renal outcomes: updated systematic review and meta-analysis.. ### Response: Xie X.


Instruction: SPRINT Research Group Wright JT Jr., Williamson JD, and others. A random-ized trial of intensive versus standard blood pressure control.

Output: N Engl J Med. 2015;373:2103–16

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: SPRINT Research Group Wright JT Jr., Williamson JD, and others. A random-ized trial of intensive versus standard blood pressure control.. ### Response: N Engl J Med. 2015;373:2103–16.


Instruction: What is the difference between standard blood-pressure control and blood pressure reduction?

Output: More versus less intensive blood pressure-lowering strategy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between standard blood-pressure control and blood pressure reduction?. ### Response: More versus less intensive blood pressure-lowering strategy.


Instruction: What does N Engl J Med. 2015:373:2103-16. Segment S4.4-35.

Output: A random-ized trial of intensive versus standard blood-pressure control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does N Engl J Med. 2015:373:2103-16. Segment S4.4-35.. ### Response: A random-ized trial of intensive versus standard blood-pressure control.


Instruction: What are the effects of different blood pressure-lowering regimens on?

Output: major cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the effects of different blood pressure-lowering regimens on?. ### Response: major cardiovascular events.


Instruction: What is the name of the meta-analysis of randomized trials?

Output: network

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis of randomized trials?. ### Response: network.


Instruction: What are the effects of blood pressure low-ering on outcome incidence in hypertension?

Output: 7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the effects of blood pressure low-ering on outcome incidence in hypertension?. ### Response: 7.


Instruction: What is low-ering on outcome incidence in hypertension?

Output: Effects of blood pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is low-ering on outcome incidence in hypertension?. ### Response: Effects of blood pressure.


Instruction: What are the effects at different baseline and achieved blood pressure levels—overview and meta-analyses of randomized trials?

Output: more vs. less intensive blood pressure lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the effects at different baseline and achieved blood pressure levels—overview and meta-analyses of randomized trials?. ### Response: more vs. less intensive blood pressure lowering.


Instruction: What is a meta-analysis of disease events among persons without hypertension?

Output: Antihypertensive treat-ment and secondary prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a meta-analysis of disease events among persons without hypertension?. ### Response: Antihypertensive treat-ment and secondary prevention.


Instruction: What is the JAMA 305:913-22?

Output: meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the JAMA 305:913-22?. ### Response: meta-analysis.


Instruction: How does blood pressure low-ering affect outcome incidence?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does blood pressure low-ering affect outcome incidence?. ### Response: 2.


Instruction: What is the name of a study that looked at blood pressure levels?

Output: Blood Pressure Lowering Treatment Trialists’ Collaboration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of a study that looked at blood pressure levels?. ### Response: Blood Pressure Lowering Treatment Trialists’ Collaboration.


Instruction: What was the title of the study?

Output: Antihypertensive treat-ment and secondary prevention of cardiovascular disease events among persons without hypertension: a meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the title of the study?. ### Response: Antihypertensive treat-ment and secondary prevention of cardiovascular disease events among persons without hypertension: a meta-analysis.


Instruction: How many patients were enrolled in a randomized trial in 2016?

Output: 613

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were enrolled in a randomized trial in 2016?. ### Response: 613.


Instruction: What is the name of the network meta-analysis of randomized trials?

Output: Optimal systolic blood pres-sure target after SPRINT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the network meta-analysis of randomized trials?. ### Response: Optimal systolic blood pres-sure target after SPRINT.


Instruction: What is a systolic blood pressure target after SPRINT?

Output: Optimal systolic blood pres-sure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a systolic blood pressure target after SPRINT?. ### Response: Optimal systolic blood pres-sure.


Instruction: What do anticoagulation guidelines apply to for catheter ablation?

Output: periprocedural anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do anticoagulation guidelines apply to for catheter ablation?. ### Response: periprocedural anticoagulation.


Instruction: How many patients were in a randomized trial of uninterrupted warfarin compared with interruption with heparin bridging?

Output: 1,584

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were in a randomized trial of uninterrupted warfarin compared with interruption with heparin bridging?. ### Response: 1,584.


Instruction: What did a randomized trial of uninterrupted rivaroxabanvs uninterrupted VKA in AF ablation demonstrate?

Output: similar event rates in both arms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a randomized trial of uninterrupted rivaroxabanvs uninterrupted VKA in AF ablation demonstrate?. ### Response: similar event rates in both arms.


Instruction: What was found to be associated with fewer bleedingcomplications than uninterrupted warfarin?

Output: dabigatran

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was found to be associated with fewer bleedingcomplications than uninterrupted warfarin?. ### Response: dabigatran.


Instruction: What is the use of uninterrupted anticoagulation forelectrophysiology procedures?

Output: these studies were open-label, they strongly support

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the use of uninterrupted anticoagulation forelectrophysiology procedures?. ### Response: these studies were open-label, they strongly support.


Instruction: What are systematic reviews with meta-analyses that include studies with such patients consistent with?

Output: results

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are systematic reviews with meta-analyses that include studies with such patients consistent with?. ### Response: results.


Instruction: Clinical observations indicate that AF and stroke are often what?

Output: temporally discordant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Clinical observations indicate that AF and stroke are often what?. ### Response: temporally discordant.


Instruction: What is associated with discontinuation of OAC after catheter ablation?

Output: increased risk of stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with discontinuation of OAC after catheter ablation?. ### Response: increased risk of stroke.


Instruction: What may confer a long-term risk of stroke?

Output: postoperative AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may confer a long-term risk of stroke?. ### Response: postoperative AF.


Instruction: How many patients were hospitalized for surgery?

Output: 1.7 million

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were hospitalized for surgery?. ### Response: 1.7 million.


Instruction: AF was associated with an increased long-term risk of what?

Output: ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: AF was associated with an increased long-term risk of what?. ### Response: ischemic stroke.


Instruction: Evidence-Based Medicine [154#5 CHEST NOVEMBER 2018]

Output: dabigatran was associated with fewer bleedingcomplications than uninterrupted warfarin.300Althoughthese studies were open-label, they strongly support theuse of uninterrupted anticoagulation forelectrophysiology procedures ( Table 9 ).298-301Tworecent systematic reviews with meta-analyses thatinclude studies with such patients consistent withresults.302,303Long-term Anticoagulation After Restoration ofSinus RhythmClinical observations indicate that AF and stroke areoften temporally discordant, with stroke occurringduring periods of sinus rhythm in the majority ofpatients with paroxysmal AF.304

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Evidence-Based Medicine [154#5 CHEST NOVEMBER 2018]. ### Response: dabigatran was associated with fewer bleedingcomplications than uninterrupted warfarin.300Althoughthese studies were open-label, they strongly support theuse of uninterrupted anticoagulation forelectrophysiology procedures ( Table 9 ).298-301Tworecent systematic reviews with meta-analyses thatinclude studies with such patients consistent withresults.302,303Long-term Anticoagulation After Restoration ofSinus RhythmClinical observations indicate that AF and stroke areoften temporally discordant, with stroke occurringduring periods of sinus rhythm in the majority ofpatients with paroxysmal AF.304.


Instruction: What is the name of the microbiology of PPM/ICD infections?

Output: n /H11005189

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the microbiology of PPM/ICD infections?. ### Response: n /H11005189.


Instruction: What is the CHA2DS2-VASc score?

Output: 1 in men and 2 in women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the CHA2DS2-VASc score?. ### Response: 1 in men and 2 in women.


Instruction: What is a factor Xa inhibitor?

Output: rivaroxaban or edoxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a factor Xa inhibitor?. ### Response: rivaroxaban or edoxaban.


Instruction: What are the exclusion criteria now defined as?

Output: moderate-to-severe mitral stenosis or a mechanical heart valve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the exclusion criteria now defined as?. ### Response: moderate-to-severe mitral stenosis or a mechanical heart valve.


Instruction: What was the recommendation changed in response to the approval of edoxaban?

Output: moderate-to-severe mitral stenosis or a mechanical heart valve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the recommendation changed in response to the approval of edoxaban?. ### Response: moderate-to-severe mitral stenosis or a mechanical heart valve.


Instruction: What is a CHA2DS2-VASc score of 1 in men and 2 in women?

Output: AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a CHA2DS2-VASc score of 1 in men and 2 in women?. ### Response: AF.


Instruction: What may be considered for patients with AF?

Output: prescribing an oral anticoagulant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered for patients with AF?. ### Response: prescribing an oral anticoagulant.


Instruction: What may be considered to reduce thromboembolic stroke risk?

Output: prescribing an oral anticoagulant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered to reduce thromboembolic stroke risk?. ### Response: prescribing an oral anticoagulant.


Instruction: What is now defined as moderate-to-severe mitral stenosis?

Output: Exclusion criteria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is now defined as moderate-to-severe mitral stenosis?. ### Response: Exclusion criteria.


Instruction: Evidence was added to support separate risk scores by what?

Output: sex

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Evidence was added to support separate risk scores by what?. ### Response: sex.


Instruction: What is not recommended in patients with AF and end-stage CKD or on dialysis?

Output: direct thrombin inhibitor dabigatran or the factor Xa inhibitors rivaroxaban or edoxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended in patients with AF and end-stage CKD or on dialysis?. ### Response: direct thrombin inhibitor dabigatran or the factor Xa inhibitors rivaroxaban or edoxaban.