Instruction: Where is the Office of Quality and Patient Safety located?

Output: VA, Washington, DC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the Office of Quality and Patient Safety located?. ### Response: VA, Washington, DC.


Instruction: What is the name of the office of quality and patient safety?

Output: The Office of Quality and Patient Safety

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the office of quality and patient safety?. ### Response: The Office of Quality and Patient Safety.


Instruction: What percentage of patients with AF presenting in the ED are eligible for warfarin but are either undertreated or untreated?

Output: ≈12% to 34%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients with AF presenting in the ED are eligible for warfarin but are either undertreated or untreated?. ### Response: ≈12% to 34%.


Instruction: What is an important location to identify patients with new-onset AF?

Output: The ED

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an important location to identify patients with new-onset AF?. ### Response: The ED.


Instruction: What do patients with new-onset AF need to initiate anticoagula-tion depending on comorbidities?

Output: The ED

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do patients with new-onset AF need to initiate anticoagula-tion depending on comorbidities?. ### Response: The ED.


Instruction: What do ED encounters for patients with known AF provide opportunities to promote?

Output: behaviors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do ED encounters for patients with known AF provide opportunities to promote?. ### Response: behaviors.


Instruction: What is a major contributor to many ED visits?

Output: Alcohol consumption

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a major contributor to many ED visits?. ### Response: Alcohol consumption.


Instruction: What has been investigated in response to the epidemic of alcohol-related injuries and illnesses?

Output: ED-based interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been investigated in response to the epidemic of alcohol-related injuries and illnesses?. ### Response: ED-based interventions.


Instruction: What did Emergency Physicians develop that did not require significant resources to produce or distribute?

Output: a brief alcohol use intervention bro-chure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Emergency Physicians develop that did not require significant resources to produce or distribute?. ### Response: a brief alcohol use intervention bro-chure.


Instruction: What was found to be marginally effective in the absence of referral for cessation counseling?

Output: alcohol use intervention bro-chure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was found to be marginally effective in the absence of referral for cessation counseling?. ### Response: alcohol use intervention bro-chure.


Instruction: More interactive interventions require more resources but are more likely to produce what?

Output: enduring benefits

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: More interactive interventions require more resources but are more likely to produce what?. ### Response: enduring benefits.


Instruction: Interventions require more resources but are more likely to produce what?

Output: enduring benefits

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Interventions require more resources but are more likely to produce what?. ### Response: enduring benefits.


Instruction: Integrating health promotion into the curriculum of emergency medicine training programs will help overcome what type of nihilism?

Output: existing nihilism of many practicing emergency physicians related to the benefit of alcohol interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Integrating health promotion into the curriculum of emergency medicine training programs will help overcome what type of nihilism?. ### Response: existing nihilism of many practicing emergency physicians related to the benefit of alcohol interventions.


Instruction: What are potential lifestyle targets for emergency physicians?

Output: Nutrition, physical activity, and drug abuse

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are potential lifestyle targets for emergency physicians?. ### Response: Nutrition, physical activity, and drug abuse.


Instruction: What are potential lifestyle targets for behavioral interventions aimed at pri-mary stroke prevention?

Output: Nutrition, physical activity, and drug abuse

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are potential lifestyle targets for behavioral interventions aimed at pri-mary stroke prevention?. ### Response: Nutrition, physical activity, and drug abuse.


Instruction: In what setting has only the feasibility and efficacy of substance abuse screening and intervention been studied?

Output: adult ED setting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what setting has only the feasibility and efficacy of substance abuse screening and intervention been studied?. ### Response: adult ED setting.


Instruction: What was recently done in a pediatric ED?

Output: an obe-sity screening study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was recently done in a pediatric ED?. ### Response: an obe-sity screening study.


Instruction: What percentage of children in an ED were overweight or obese?

Output: more than half

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of children in an ED were overweight or obese?. ### Response: more than half.


Instruction: What contributes to medical conditions seen in the ED?

Output: Alcohol consumption

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What contributes to medical conditions seen in the ED?. ### Response: Alcohol consumption.


Instruction: Many physicians are reluctant to discuss what?

Output: issues related to a patient’s weight

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Many physicians are reluctant to discuss what?. ### Response: issues related to a patient’s weight.


Instruction: What are emergency physicians reluctant to discuss?

Output: issues related to a patient’s weight

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are emergency physicians reluctant to discuss?. ### Response: issues related to a patient’s weight.


Instruction: What are patients not always receptive to?

Output: the discussion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients not always receptive to?. ### Response: the discussion.


Instruction: No study has investigated the use of the ED as a site for what?

Output: nutritional and dietary counseling

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No study has investigated the use of the ED as a site for what?. ### Response: nutritional and dietary counseling.


Instruction: What do few practice routine screening and counseling of emergency patients?

Output: emergency physicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do few practice routine screening and counseling of emergency patients?. ### Response: emergency physicians.


Instruction: What are many skepti-cal of the effect of ED health promotion?

Output: emergency physicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are many skepti-cal of the effect of ED health promotion?. ### Response: emergency physicians.


Instruction: What can serve as an effective location to educate patients about stroke signs and symptoms and the need to seek immediate medical attention?

Output: the ED

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can serve as an effective location to educate patients about stroke signs and symptoms and the need to seek immediate medical attention?. ### Response: the ED.


Instruction: What was used in a pilot study of stroke education?

Output: educational videos

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was used in a pilot study of stroke education?. ### Response: educational videos.


Instruction: What type of counseling did the intervention group receive compared to a control group that did not receive any intervention?

Output: cessation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of counseling did the intervention group receive compared to a control group that did not receive any intervention?. ### Response: cessation.


Instruction: What does 1 provide for writing recommen-dations within each COR?

Output: suggested phrases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does 1 provide for writing recommen-dations within each COR?. ### Response: suggested phrases.


Instruction: What is a new addition to this methodology?

Output: separation of the Class III recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a new addition to this methodology?. ### Response: separation of the Class III recommendations.


Instruction: What has been added in view of the increasing number of comparative effectiveness studies?

Output: com-parator verbs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been added in view of the increasing number of comparative effectiveness studies?. ### Response: com-parator verbs.


Instruction: What have been added for COR I and IIa, LOEA or B?

Output: com-parator verbs and suggested phrases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have been added for COR I and IIa, LOEA or B?. ### Response: com-parator verbs and suggested phrases.


Instruction: What does GDMT stand for?

Output: guideline -directed medical therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does GDMT stand for?. ### Response: guideline -directed medical therapy.


Instruction: What is class I?

Output: ACCF/AHA guideline–recommended therapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is class I?. ### Response: ACCF/AHA guideline–recommended therapies.


Instruction: What drug will be used in the ACCF/AHA practice guidelines?

Output: GDMT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug will be used in the ACCF/AHA practice guidelines?. ### Response: GDMT.


Instruction: Why are drugs that are not currently available in North America discussed in the text without a specific COR?

Output: Because the ACCF/AHA practice guidelines address pa-tient populations (and healthcare providers) residing in NorthAmerica

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why are drugs that are not currently available in North America discussed in the text without a specific COR?. ### Response: Because the ACCF/AHA practice guidelines address pa-tient populations (and healthcare providers) residing in NorthAmerica.


Instruction: What is the purpose of the ACCF/AHA practice guidelines?

Output: improvement inquality of care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of the ACCF/AHA practice guidelines?. ### Response: improvement inquality of care.


Instruction: What does each writing committee review to determine whether the findings should inform a recommendation?

Output: the potential influ-ence of different practice patterns and patient populations onthe treatment effect and relevance to the ACCF/AHA targetpopulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does each writing committee review to determine whether the findings should inform a recommendation?. ### Response: the potential influ-ence of different practice patterns and patient populations onthe treatment effect and relevance to the ACCF/AHA targetpopulation.


Instruction: What are ACCF/AHA practice guidelines intended to assist in?

Output: clinical decision making

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are ACCF/AHA practice guidelines intended to assist in?. ### Response: clinical decision making.


Instruction: What do ACCF and AHA practice guides attempt to define?

Output: practices that meet the needs ofmost patients in most circumstances

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do ACCF and AHA practice guides attempt to define?. ### Response: practices that meet the needs ofmost patients in most circumstances.


Instruction: In most cases, who makes the final judgment regarding care of a particular patient?

Output: thehealthcare provider and patient

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In most cases, who makes the final judgment regarding care of a particular patient?. ### Response: thehealthcare provider and patient.


Instruction: What must the health care provider and patient do in light of all the circumstancespresented by that patient?

Output: The ultimate judgmentregarding the care of a particular patient

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must the health care provider and patient do in light of all the circumstancespresented by that patient?. ### Response: The ultimate judgmentregarding the care of a particular patient.


Instruction: What should clinical decision making involve consideration of?

Output: quality and availability of expertise in the area where care isprovided

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should clinical decision making involve consideration of?. ### Response: quality and availability of expertise in the area where care isprovided.


Instruction: What should the goal be when guidelines are used as the basis for regulatory or payer decisions?

Output: improvement inquality of care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should the goal be when guidelines are used as the basis for regulatory or payer decisions?. ### Response: improvement inquality of care.


Instruction: What does the Task Force recognize that situations arise in which additional data are needed to inform patient care more effectively?

Output: comparative effectiveness studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Task Force recognize that situations arise in which additional data are needed to inform patient care more effectively?. ### Response: comparative effectiveness studies.


Instruction: What is effective only if prescribed courses of treatment are followed?

Output: lack

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is effective only if prescribed courses of treatment are followed?. ### Response: lack.


Instruction: What did Meschia et al Guidelines for the Primary Prevention of Stroke 3795trembophilia compared with?

Output: no screening

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Meschia et al Guidelines for the Primary Prevention of Stroke 3795trembophilia compared with?. ### Response: no screening.


Instruction: What was more cost-effective than universal screening?

Output: Selective screening based on prior venous thromboembolism history

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was more cost-effective than universal screening?. ### Response: Selective screening based on prior venous thromboembolism history.


Instruction: What is very little evidence to guide the management of asymptomatic people with thrombophilia?

Output: Inherited Hypercoagulable State

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is very little evidence to guide the management of asymptomatic people with thrombophilia?. ### Response: Inherited Hypercoagulable State.


Instruction: What did a systematic review of prospective observational studies indicate occurred during periods of high risk such as surgery, trauma, or pregnancy?

Output: venous thromboembolic events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a systematic review of prospective observational studies indicate occurred during periods of high risk such as surgery, trauma, or pregnancy?. ### Response: venous thromboembolic events.


Instruction: What would be likely to be effic-tive during these periods?

Output: antithrombotic pro-phylaxis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would be likely to be effic-tive during these periods?. ### Response: antithrombotic pro-phylaxis.


Instruction: What is not known about the effect of prophylaxis on the incidence of stroke or TIA in these subjects?

Output: the effect of prophylaxis on the incidence of stroke or TIA in these subjects is not known

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not known about the effect of prophylaxis on the incidence of stroke or TIA in these subjects?. ### Response: the effect of prophylaxis on the incidence of stroke or TIA in these subjects is not known.


Instruction: What are hypercoagulable states associated with?

Output: venous thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are hypercoagulable states associated with?. ### Response: venous thrombosis.


Instruction: What is the association with arterial cerebral infarction uncertain?

Output: Hypercoagulability: Summary and GapsInherited and acquired hypercoagulable states

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association with arterial cerebral infarction uncertain?. ### Response: Hypercoagulability: Summary and GapsInherited and acquired hypercoagulable states.


Instruction: Young women with isch-emic stroke have a higher prevalence of what?

Output: aPL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Young women with isch-emic stroke have a higher prevalence of what?. ### Response: aPL.


Instruction: The majority of case-control studies have not found an association between what two things?

Output: arterial cerebral infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The majority of case-control studies have not found an association between what two things?. ### Response: arterial cerebral infarction.


Instruction: What should be done to refine the risks and establish the associations of thrombophilias with venous veins?

Output: Large prospective studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be done to refine the risks and establish the associations of thrombophilias with venous veins?. ### Response: Large prospective studies.


Instruction: What type of states are associated with stroke in other patient populations?

Output: acquired or hereditary hypercoagulable

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of states are associated with stroke in other patient populations?. ### Response: acquired or hereditary hypercoagulable.


Instruction: The relationship between the presence of PFO and what else deserves further study?

Output: thrombophilia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The relationship between the presence of PFO and what else deserves further study?. ### Response: thrombophilia.


Instruction: What is the pathogenic role of prothrombotic abnormalities in childhood and young adult ischemic stroke?

Output: the lack of any clinical trial data precludes definitive recommendations for screening or treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the pathogenic role of prothrombotic abnormalities in childhood and young adult ischemic stroke?. ### Response: the lack of any clinical trial data precludes definitive recommendations for screening or treatment.


Instruction: What precludes definitive recommendations for screening or treatment?

Output: lack of any clinical trial data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What precludes definitive recommendations for screening or treatment?. ### Response: lack of any clinical trial data.


Instruction: What is not well established to detect inher-ited hypercoagulable states?

Output: genetic screening

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not well established to detect inher-ited hypercoagulable states?. ### Response: genetic screening.


Instruction: What is not well established for primary stroke prevention in asymptomatic patients with a hereditary or acquired thrombophilia?

Output: The usefulness of specific treatments

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not well established for primary stroke prevention in asymptomatic patients with a hereditary or acquired thrombophilia?. ### Response: The usefulness of specific treatments.


Instruction: Low-dose aspirin (81 mg/d) is not indicated for what in individuals who are persistently aPL positive?

Output: pri-mary stroke prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Low-dose aspirin (81 mg/d) is not indicated for what in individuals who are persistently aPL positive?. ### Response: pri-mary stroke prevention.


Instruction: What is a class III; Level of Evidence B?

Output: Inflammation and Infection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a class III; Level of Evidence B?. ### Response: Inflammation and Infection.


Instruction: What affects the initiation, growth, and stability of atherosclerotic lesions?

Output: Inflammation and InfectionInflammation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What affects the initiation, growth, and stability of atherosclerotic lesions?. ### Response: Inflammation and InfectionInflammation.


Instruction: Inflammation has pro-thrombotic effects and plays a role in what?

Output: major stroke risk fac-tors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Inflammation has pro-thrombotic effects and plays a role in what?. ### Response: major stroke risk fac-tors.


Instruction: What is the value of assessing inflammation in assessing risk to optimize the primary prevention of stroke?

Output: contro-versial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the value of assessing inflammation in assessing risk to optimize the primary prevention of stroke?. ### Response: contro-versial.


Instruction: What are some of the serum markers of inflammation?

Output: fibrinogen, serum amyloid A, lipoprotein-associated phospholi-

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the serum markers of inflammation?. ### Response: fibrinogen, serum amyloid A, lipoprotein-associated phospholi-.


Instruction: What is an important consideration?

Output: Age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an important consideration?. ### Response: Age.


Instruction: What is greater in those 30 years of age?

Output: sudden death risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is greater in those 30 years of age?. ### Response: sudden death risk.


Instruction: What is the most common cause of SCD in individuals 40 years of age?

Output: HCM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common cause of SCD in individuals 40 years of age?. ### Response: HCM.


Instruction: What are patients who have survived an episode of VF or sustained VT resulting in syncope or hemodynamic compromise warrant?

Output: ICD  implantation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients who have survived an episode of VF or sustained VT resulting in syncope or hemodynamic compromise warrant?. ### Response: ICD  implantation.


Instruction: What are two reasons for ICD implantation?

Output: Individuals who have survived an episode of SCD, VF, or sustained VT resulting in syncope  or hemodynamic compromise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are two reasons for ICD implantation?. ### Response: Individuals who have survived an episode of SCD, VF, or sustained VT resulting in syncope  or hemodynamic compromise.


Instruction: What percentage of patients with an ICD placed for secondary prevention received appro-priate ICD therapy during an average follow-up?

Output: 54%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients with an ICD placed for secondary prevention received appro-priate ICD therapy during an average follow-up?. ### Response: 54%.


Instruction: How long did it take for patients placed for secondary prevention to receive appropriate ICD therapy?

Output: 4.6 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for patients placed for secondary prevention to receive appropriate ICD therapy?. ### Response: 4.6 years.


Instruction: What type of patient may be candidates for implantation of the subcutaneous implantable cardioverter-defibrillator?

Output: Select patients with HCM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of patient may be candidates for implantation of the subcutaneous implantable cardioverter-defibrillator?. ### Response: Select patients with HCM.


Instruction: Which group has a higher risk of T wave oversensing?

Output: HCM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which group has a higher risk of T wave oversensing?. ### Response: HCM.


Instruction: What may increase the risk of inappropriate ICD shocks?

Output: T wave oversensing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may increase the risk of inappropriate ICD shocks?. ### Response: T wave oversensing.


Instruction: What is important to identify those with unrec-ognized disease?

Output: Genetic counseling

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is important to identify those with unrec-ognized disease?. ### Response: Genetic counseling.


Instruction: Genetic counseling should precede what?

Output: genetic testing of family members

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Genetic counseling should precede what?. ### Response: genetic testing of family members.


Instruction: How is the pattern of inheri-tance ascertained to identify and manage relatives at risk?

Output: family history, clinical screening, and  pedigree analyses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the pattern of inheri-tance ascertained to identify and manage relatives at risk?. ### Response: family history, clinical screening, and  pedigree analyses.


Instruction: Why is familial HCM a dominant disorder?

Output: the risk that an affected patient will transmit disease to each offspring is 50%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is familial HCM a dominant disorder?. ### Response: the risk that an affected patient will transmit disease to each offspring is 50%..


Instruction: What is familial HCM?

Output: a dominant disorder

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is familial HCM?. ### Response: a dominant disorder.


Instruction: What is the risk that an affected patient will transmit disease to each offspring?

Output: 50%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk that an affected patient will transmit disease to each offspring?. ### Response: 50%..


Instruction: When is a pathogenic mutation identified in an index patient?

Output: the genetic status of each family member can be readily ascertained

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is a pathogenic mutation identified in an index patient?. ### Response: the genetic status of each family member can be readily ascertained.


Instruction: Relatives with overt HCM will have what?

Output: the same patho-genic HCM mutation as the index patient

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Relatives with overt HCM will have what?. ### Response: the same patho-genic HCM mutation as the index patient.


Instruction: What will have the same patho-genic HCM mutation as the index patient?

Output: Relatives with overt HCM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will have the same patho-genic HCM mutation as the index patient?. ### Response: Relatives with overt HCM.


Instruction: What may also be identified in other relatives with unknown clinical status?

Output: Pathogenic mutations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may also be identified in other relatives with unknown clinical status?. ### Response: Pathogenic mutations.


Instruction: Who should undergo risk stratification if HCM is identified?

Output: these individuals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should undergo risk stratification if HCM is identified?. ### Response: these individuals.


Instruction: What may be at risk for future development of HCM?

Output: Gene-positive subjects with-out evidence of HCM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be at risk for future development of HCM?. ### Response: Gene-positive subjects with-out evidence of HCM.


Instruction: Who benefit from ongoing clinical evaluation?

Output: Gene-positive subjects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who benefit from ongoing clinical evaluation?. ### Response: Gene-positive subjects.


Instruction: What is a bona fide disease-causing mutation?

Output: proband’s implicated mutation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a bona fide disease-causing mutation?. ### Response: proband’s implicated mutation.


Instruction: What must mutation-negative family members have to ensure?

Output: an echocardiogram to ensure genotype and pheno-type concordance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must mutation-negative family members have to ensure?. ### Response: an echocardiogram to ensure genotype and pheno-type concordance.


Instruction: What is less accurate than TTE and TEE for identifying valvular vegetation and perfo-rations?

Output: CT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is less accurate than TTE and TEE for identifying valvular vegetation and perfo-rations?. ### Response: CT.


Instruction: What is CT useful for evaluating patients with equivocal findings on TEE?

Output: CT is less accurate than TTE and TEE for identifying valvular vegetation and valvular perfo-rations, CT is useful for evaluating patients with equivocal findings on TEE and for evaluating com-plications in patients with suspected paravalvular infection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CT useful for evaluating patients with equivocal findings on TEE?. ### Response: CT is less accurate than TTE and TEE for identifying valvular vegetation and valvular perfo-rations, CT is useful for evaluating patients with equivocal findings on TEE and for evaluating com-plications in patients with suspected paravalvular infection.


Instruction: What is particularly useful in pre-operative evaluation of patients with aortic valve IE?

Output: CT imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is particularly useful in pre-operative evaluation of patients with aortic valve IE?. ### Response: CT imaging.


Instruction: What is less affected by the shadowing of mechanical valves or bioprosthetic valve sew-ing rings than is ultrasonography?

Output: cardiac CT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is less affected by the shadowing of mechanical valves or bioprosthetic valve sew-ing rings than is ultrasonography?. ### Response: cardiac CT.


Instruction: What allows evaluation of the motion of mechanical valve occluders?

Output: CT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What allows evaluation of the motion of mechanical valve occluders?. ### Response: CT.


Instruction: What provides visualization of throm-bus?

Output: CT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What provides visualization of throm-bus?. ### Response: CT.


Instruction: Cardiovascular valvular fluoroscopy can be an adjunct to other what?

Output: clinical and imaging information

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cardiovascular valvular fluoroscopy can be an adjunct to other what?. ### Response: clinical and imaging information.


Instruction: What can be an adjunct to other clinical and imaging information to detect the presence of obstructive disease in mechanical prosthetic valves?

Output: 18F-fluorodeoxyglucose PET/CT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be an adjunct to other clinical and imaging information to detect the presence of obstructive disease in mechanical prosthetic valves?. ### Response: 18F-fluorodeoxyglucose PET/CT.


Instruction: What can still be a vexing under -taking?

Output: Diagnosis of IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can still be a vexing under -taking?. ### Response: Diagnosis of IE.


Instruction: What increases the diagnostic capability of the Modified Duke Criteria?

Output: initial presentation of patients with suspected pros-thetic valve endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What increases the diagnostic capability of the Modified Duke Criteria?. ### Response: initial presentation of patients with suspected pros-thetic valve endocarditis.


Instruction: What percentage of patients with prosthetic valve endocarditis were recatego-rized after the inclusion of abnormal 18F-fluorodeoxyglucose?

Output: 76%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients with prosthetic valve endocarditis were recatego-rized after the inclusion of abnormal 18F-fluorodeoxyglucose?. ### Response: 76%.


Instruction: How many patients with prosthetic valve endocarditis were recatego-rized?

Output: 76%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with prosthetic valve endocarditis were recatego-rized?. ### Response: 76%.


Instruction: What percentage of patients were initially classified as “possible” IE on admission to the hospital?

Output: 76%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients were initially classified as “possible” IE on admission to the hospital?. ### Response: 76%.


Instruction: Where must this tool be used because it may be prone to false-positive results?

Output: centers with great experi-ence with the technology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where must this tool be used because it may be prone to false-positive results?. ### Response: centers with great experi-ence with the technology.


Instruction: What may be prone to false-positive results?

Output: implanted prosthetic valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be prone to false-positive results?. ### Response: implanted prosthetic valves.


Instruction: What may also be considered a complementary diagnostic tool for some patients with suspected native valve endocarditis?

Output: 18F-fluorodeoxyglucose PET/CT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may also be considered a complementary diagnostic tool for some patients with suspected native valve endocarditis?. ### Response: 18F-fluorodeoxyglucose PET/CT.


Instruction: Why is the frequency of IE among patients with S. aureus bacteremia reported to be?

Output: 30%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is the frequency of IE among patients with S. aureus bacteremia reported to be?. ### Response: 30%,.


Instruction: What percentage of patients with S. aureus bacteremia have TEE?

Output: 30%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients with S. aureus bacteremia have TEE?. ### Response: 30%,.


Instruction: What may be considered to rule out IE?

Output: TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered to rule out IE?. ### Response: TEE.


Instruction: What is an example of a known extracardiac source?

Output: an infected joint or joint prosthe-sis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a known extracardiac source?. ### Response: an infected joint or joint prosthe-sis.


Instruction: What might be considered if there are known cases of seeding of valve tissue in this type of setting?

Output: TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What might be considered if there are known cases of seeding of valve tissue in this type of setting?. ### Response: TEE.


Instruction: How long does it take for symptoms of IE to resolve?

Output: 72 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take for symptoms of IE to resolve?. ### Response: 72 hours.


Instruction: What is the name of the website that ahajournals.org was able to access on April 28, 2023?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the website that ahajournals.org was able to access on April 28, 2023?. ### Response: http://ahajournals.org.


Instruction: How many hours after removal of a bacteremia and fever resolves?

Output: 72

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many hours after removal of a bacteremia and fever resolves?. ### Response: 72.


Instruction: What is the goal of titration?

Output: Achieving target or maximally tolerated doses of GDMT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the goal of titration?. ### Response: Achieving target or maximally tolerated doses of GDMT.


Instruction: How often should beta-blocker doses be adjusted?

Output: every 2 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often should beta-blocker doses be adjusted?. ### Response: every 2 weeks.


Instruction: Beta-blocker doses should be adjusted every 2 weeks (43)i nap a t i e n tw i do n what?

Output: decompensated HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Beta-blocker doses should be adjusted every 2 weeks (43)i nap a t i e n tw i do n what?. ### Response: decompensated HF.


Instruction: Longer time periods may be needed for frail pa-tients or those with what condition?

Output: marginal hemodynamics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Longer time periods may be needed for frail pa-tients or those with what condition?. ### Response: marginal hemodynamics.


Instruction: What may be needed for frail patients or those with marginal hemodynamics?

Output: Longer time periods

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be needed for frail patients or those with marginal hemodynamics?. ### Response: Longer time periods.


Instruction: More rapid titration may be reasonable in clinically stablepatients without what?

Output: hypotension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: More rapid titration may be reasonable in clinically stablepatients without what?. ### Response: hypotension.


Instruction: What is the preferred renin-angiotensin inhibitor in the absence of hypotension, electrolyte/renal instability, or prior angioedema on an ACEI?

Output: An ARNI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the preferred renin-angiotensin inhibitor in the absence of hypotension, electrolyte/renal instability, or prior angioedema on an ACEI?. ### Response: An ARNI.


Instruction: What should be used if administration of an ARNI is not possible?

Output: ACEI or ARB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be used if administration of an ARNI is not possible?. ### Response: ACEI or ARB.


Instruction: What might be titrated similarly to beta-blockers with monitoring of renal function, potassium and blood pressure?

Output: ARNI/ACEI/ARB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What might be titrated similarly to beta-blockers with monitoring of renal function, potassium and blood pressure?. ### Response: ARNI/ACEI/ARB.


Instruction: What can be increased every 2weeks for those taking an ARNI to allow time for adjustment to the vasodilatoryeffects of the combined inhi bition of the angiotensinreceptor and neprilysin?

Output: doses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be increased every 2weeks for those taking an ARNI to allow time for adjustment to the vasodilatoryeffects of the combined inhi bition of the angiotensinreceptor and neprilysin?. ### Response: doses.


Instruction: What is important to monitor for optimal titration of an ARNI/ACEI/ARB?

Output: renal function, potassium, and blood pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is important to monitor for optimal titration of an ARNI/ACEI/ARB?. ### Response: renal function, potassium, and blood pressure.


Instruction: What may be necessary to reduce HFrEF?

Output: lower loopdiuretic doses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be necessary to reduce HFrEF?. ### Response: lower loopdiuretic doses.


Instruction: What is added as part of the therapy for patients with symptomatic chronic HFfrEF who are already receiving beta-blockers and ACEI/ARB?

Output: Aldosterone antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is added as part of the therapy for patients with symptomatic chronic HFfrEF who are already receiving beta-blockers and ACEI/ARB?. ### Response: Aldosterone antagonists.


Instruction: What is not necessary to achieve target or maxi-mally tolerated doses of othe r drugs before adding aldo-sterone antagonists?

Output: It

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not necessary to achieve target or maxi-mally tolerated doses of othe r drugs before adding aldo-sterone antagonists?. ### Response: It.


Instruction: What is typically below those that might in fluence blood pressure?

Output: The doses of aldosterone antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is typically below those that might in fluence blood pressure?. ### Response: The doses of aldosterone antagonists.


Instruction: Adherence to the guideline is sufficient for what?

Output: monitoring of renal function and potassium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Adherence to the guideline is sufficient for what?. ### Response: monitoring of renal function and potassium.


Instruction: What is required for monitoring of renal function and potassium?

Output: Adherence to the guideline recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is required for monitoring of renal function and potassium?. ### Response: Adherence to the guideline recommendations.


Instruction: What is added as part of the therapy for patients with chronic HFrEF who are already receivingbeta-blockers?

Output: SGLT2 inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is added as part of the therapy for patients with chronic HFrEF who are already receivingbeta-blockers?. ### Response: SGLT2 inhibitors.


Instruction: Aldosterone an-tagonists, if not contraindicated, are what?

Output: SGLT2 inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Aldosterone an-tagonists, if not contraindicated, are what?. ### Response: SGLT2 inhibitors.


Instruction: There is little data regarding the combination of an ARNI and an SGLT2inhibitor?

Output: There is little dataaddressing the combination of an ARNI and an SGLT2inhibitor. However, in both DAPA-HF and EMPEROR-Reduced, the bene ﬁ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is little data regarding the combination of an ARNI and an SGLT2inhibitor?. ### Response: There is little dataaddressing the combination of an ARNI and an SGLT2inhibitor. However, in both DAPA-HF and EMPEROR-Reduced, the bene ﬁ.


Instruction: In both DAPA-HF and EMPEROR-Reduced, the bene fit of what was consistent?

Output: SGLT2 inhibition

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In both DAPA-HF and EMPEROR-Reduced, the bene fit of what was consistent?. ### Response: SGLT2 inhibition.


Instruction: What year was stroke associated with an approximate doubling of risk?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was stroke associated with an approximate doubling of risk?. ### Response: 2014.


Instruction: What is smoking also associated with?

Output: hemorrhagic stroke risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is smoking also associated with?. ### Response: hemorrhagic stroke risk.


Instruction: Smoking is associated with a 2- to 3- to 4- to 3-to 4-to-three-toed of what?

Output: SAH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Smoking is associated with a 2- to 3- to 4- to 3-to 4-to-three-toed of what?. ### Response: SAH.


Instruction: What is smoking associated with a 2- to 4-fold increased risk for?

Output: SAH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is smoking associated with a 2- to 4-fold increased risk for?. ### Response: SAH.


Instruction: What is inconsistent with the data for ICH?

Output: A multicenter case-control study found an adjusted OR of 1.58 (95% CI, 1.02–2.44)333

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is inconsistent with the data for ICH?. ### Response: A multicenter case-control study found an adjusted OR of 1.58 (95% CI, 1.02–2.44)333.


Instruction: A multicenter case-control study found an adjusted OR of what?

Output: 1.58

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A multicenter case-control study found an adjusted OR of what?. ### Response: 1.58.


Instruction: What did the Physicians’ Health Study332 and WHS331 find?

Output: such an association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Physicians’ Health Study332 and WHS331 find?. ### Response: such an association.


Instruction: What did other studies find no relationship between?

Output: smoking and ICH risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did other studies find no relationship between?. ### Response: smoking and ICH risk.


Instruction: How many studies estimated the RR for ischemic stroke?

Output: 32

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies estimated the RR for ischemic stroke?. ### Response: 32.


Instruction: What is the RR for ischemic stroke for smokers versus nonsmokers?

Output: 1.9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the RR for ischemic stroke for smokers versus nonsmokers?. ### Response: 1.9.


Instruction: What is it for SAH?

Output: 2.9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is it for SAH?. ### Response: 2.9.


Instruction: How many stroke deaths are attributed to smoking in the U.S.?

Output: 21 400

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many stroke deaths are attributed to smoking in the U.S.?. ### Response: 21 400.


Instruction: What is the estimated number of stroke deaths in the United States after adjustment for potential confounding factors?

Output: 17 800

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the estimated number of stroke deaths in the United States after adjustment for potential confounding factors?. ### Response: 17 800.


Instruction: What did the Centers for Disease Control and Prevention estimate smoking resulted in?

Output: 61 616 stroke deaths

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Centers for Disease Control and Prevention estimate smoking resulted in?. ### Response: 61 616 stroke deaths.


Instruction: What was the annual average of stroke deaths among men and women?

Output: 97 681

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the annual average of stroke deaths among men and women?. ### Response: 97 681.


Instruction: How many stroke deaths did smoking result in among women and men?

Output: 97 681

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many stroke deaths did smoking result in among women and men?. ### Response: 97 681.


Instruction: How many stroke deaths are there among women?

Output: 97 681

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many stroke deaths are there among women?. ### Response: 97 681.


Instruction: What may smoking potentiate the effects of other stroke risk factors?

Output: Exposure to environmental tobacco smoke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may smoking potentiate the effects of other stroke risk factors?. ### Response: Exposure to environmental tobacco smoke.


Instruction: How many times greater were the odds of cerebral infarc-tion for women who smoked but did not use OCs than for nonsmoking OC users?

Output: 1.3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many times greater were the odds of cerebral infarc-tion for women who smoked but did not use OCs than for nonsmoking OC users?. ### Response: 1.3.


Instruction: What percentage of the OC user's odds were 7.2 times greater than for those who did not smoke?

Output: 95% CI, 3.2–16.1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the OC user's odds were 7.2 times greater than for those who did not smoke?. ### Response: 95% CI, 3.2–16.1.


Instruction: How many times greater were the odds of hemorrhagic stroke for OC users who smoked?

Output: 3.7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many times greater were the odds of hemorrhagic stroke for OC users who smoked?. ### Response: 3.7.


Instruction: What was the synergistic effect of smoking and OC use on?

Output: risk of cerebral infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the synergistic effect of smoking and OC use on?. ### Response: risk of cerebral infarction.


Instruction: How many times greater is exposure to environmental tobacco smoke for smokers?

Output: 2- to 4-fold

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many times greater is exposure to environmental tobacco smoke for smokers?. ### Response: 2- to 4-fold.


Instruction: What is another term for passive or second-hand smoke?

Output: environmental tobacco smoke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for passive or second-hand smoke?. ### Response: environmental tobacco smoke.


Instruction: What is smoke also referred to as?

Output: Cigarette

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is smoke also referred to as?. ### Response: Cigarette.


Instruction: What is an established risk factor for heart disease?

Output: Exposure to environmental tobacco smoke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an established risk factor for heart disease?. ### Response: Exposure to environmental tobacco smoke.


Instruction: Exposure to environmental tobacco smoke may also be a risk for what?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Exposure to environmental tobacco smoke may also be a risk for what?. ### Response: stroke.


Instruction: Why is the dose of exposure to tobacco smoke significantly lower than for active smoking?

Output: 350

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is the dose of exposure to tobacco smoke significantly lower than for active smoking?. ### Response: 350.


Instruction: What is the magnitude of the risk of tobacco exposure?

Output: 2- to 4-fold

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the magnitude of the risk of tobacco exposure?. ### Response: 2- to 4-fold.


Instruction: How many studies found no association?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies found no association?. ### Response: 1.


Instruction: What is the title of the 2015 ACC/AHA/SCAI Focused Update on Primary PCI 1143?

Output: Levine et al  2015 ACC/AHA/SCAI Focused Update on Primary PCI  1143Debabrata  MukherjeeTexas Tech University—Chief, Cardiovascular Medicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of the 2015 ACC/AHA/SCAI Focused Update on Primary PCI 1143?. ### Response: Levine et al  2015 ACC/AHA/SCAI Focused Update on Primary PCI  1143Debabrata  MukherjeeTexas Tech University—Chief, Cardiovascular Medicine.


Instruction: Who is the Chief, Cardiovascular Medicine at Texas Tech University?

Output: Debabrata  Mukherjee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Chief, Cardiovascular Medicine at Texas Tech University?. ### Response: Debabrata  Mukherjee.


Instruction: Which hospital is the Senior Vice President and Chief Quality Officer at Cornell?

Output: The University Hospital of Columbia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which hospital is the Senior Vice President and Chief Quality Officer at Cornell?. ### Response: The University Hospital of Columbia.


Instruction: What table represents the relationships of committee members with industry and other entities that were determined to be relevant to this document?

Output: Appendix 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What table represents the relationships of committee members with industry and other entities that were determined to be relevant to this document?. ### Response: Appendix 1.


Instruction: What percentage of voting stock does a person have a significant interest in?

Output: ≥5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of voting stock does a person have a significant interest in?. ### Response: ≥5%.


Instruction: How much of the fair market value of the business entity does the person have?

Output: ≥5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the fair market value of the business entity does the person have?. ### Response: ≥5%.


Instruction: What is the percentage of ownership of the voting stock or share of a business entity?

Output: ≥5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the percentage of ownership of the voting stock or share of a business entity?. ### Response: ≥5%.


Instruction: How much of a person's gross income does a business entity receive?

Output: 5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of a person's gross income does a business entity receive?. ### Response: 5%.


Instruction: What is included in the table for the purpose of transparency?

Output: Relationships that exist with no financial benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is included in the table for the purpose of transparency?. ### Response: Relationships that exist with no financial benefit.


Instruction: How are relationships in this table modest?

Output: unless otherwise noted

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are relationships in this table modest?. ### Response: unless otherwise noted.


Instruction: What are relationships in this table modest unless otherwise noted?

Output: Relationships that exist with no financial benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are relationships in this table modest unless otherwise noted?. ### Response: Relationships that exist with no financial benefit.


Instruction: According to the ACC/AHA, a person has a relevant relationship if: a) the relationship or interest relates to the same or similar subject matter, intellectual property or asset addressed in the document; or b) the company/entity (with whom the relationship exists) makes what?

Output: a drug, drug class, or device addressed in the document

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: According to the ACC/AHA, a person has a relevant relationship if: a) the relationship or interest relates to the same or similar subject matter, intellectual property or asset addressed in the document; or b) the company/entity (with whom the relationship exists) makes what?. ### Response: a drug, drug class, or device addressed in the document.


Instruction: What does the company/entity make a drug, drug class, or device addressed in the document?

Output: a competing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the company/entity make a drug, drug class, or device addressed in the document?. ### Response: a competing.


Instruction: What does a person or a member of the person’s household have a reasonable potential for?

Output: financial, professional, or other personal gain or loss

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does a person or a member of the person’s household have a reasonable potential for?. ### Response: financial, professional, or other personal gain or loss.


Instruction: What are writing group members required to recuse themselves from voting on sections to which their specific relationships with industry and other entities may apply?

Output: †No financial benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are writing group members required to recuse themselves from voting on sections to which their specific relationships with industry and other entities may apply?. ### Response: †No financial benefit.


Instruction: ACC indicates which American College of Cardiology?

Output: AHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ACC indicates which American College of Cardiology?. ### Response: AHA.


Instruction: AHA, American Heart Association, and SCAI, Society for Cardiovascular Angiography and Interventions.

Output: Society for Cardiovascular

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: AHA, American Heart Association, and SCAI, Society for Cardiovascular Angiography and Interventions.. ### Response: Society for Cardiovascular.


Instruction: What does ACC stand for?

Output: Focused Update on Primary PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ACC stand for?. ### Response: Focused Update on Primary PCI.


Instruction: What is the acronym for Society for Cardiovascular Angiography and Interventions?

Output: SCAI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Society for Cardiovascular Angiography and Interventions?. ### Response: SCAI.


Instruction: What is the name of the ST-Elevation Myocardial Infarction Writing Committee?

Output: ST-Elevation Myocardial Infarction Writing Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the ST-Elevation Myocardial Infarction Writing Committee?. ### Response: ST-Elevation Myocardial Infarction Writing Committee.


Instruction: What year did the committee meet?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did the committee meet?. ### Response: 2014.


Instruction: Who was the committee member?

Output: Employment Consultant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the committee member?. ### Response: Employment Consultant.


Instruction: Powers et al 2019 Guidelines for Management of AIS e3854.11. Other4.11. Other COR LOE New, Revised, or Unchanged?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Powers et al 2019 Guidelines for Management of AIS e3854.11. Other4.11. Other COR LOE New, Revised, or Unchanged?. ### Response: 1.


Instruction: During hospitalization and inpatient rehabilitation, regular skin assessments are recommended with what?

Output: objective scales of risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: During hospitalization and inpatient rehabilitation, regular skin assessments are recommended with what?. ### Response: objective scales of risk.


Instruction: What is recommended to minimize or eliminate skin friction, to minimize skin pressure, to provide appropriate support surfaces, and to avoid excessive moisture?

Output: LOE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended to minimize or eliminate skin friction, to minimize skin pressure, to provide appropriate support surfaces, and to avoid excessive moisture?. ### Response: LOE.


Instruction: What should be maintained to prevent skin breakdown?

Output: adequate nutrition and hydration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be maintained to prevent skin breakdown?. ### Response: adequate nutrition and hydration.


Instruction: What is recommended until mobility returns?

Output: Regular turning, good skin hygiene, and use of specialized mattresses, wheelchair cushions, and seating

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended until mobility returns?. ### Response: Regular turning, good skin hygiene, and use of specialized mattresses, wheelchair cushions, and seating.


Instruction: How are C-LDRecommendation and COR unchanged from 2016?

Output: Rehab Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are C-LDRecommendation and COR unchanged from 2016?. ### Response: Rehab Guidelines.


Instruction: How was LOE amended?

Output: to conform with ACC/AHA 2015 Recommendation Classification System

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was LOE amended?. ### Response: to conform with ACC/AHA 2015 Recommendation Classification System.


Instruction: What is reasonable for patients and families with stroke to be directed to palliative care resources?

Output: as appropriate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable for patients and families with stroke to be directed to palliative care resources?. ### Response: as appropriate.


Instruction: Who should ascertain and include patient-centered preferences in decision-making?

Output: Healthcare providers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should ascertain and include patient-centered preferences in decision-making?. ### Response: Healthcare providers.


Instruction: What should healthcare providers include in decision making?

Output: patient-centered preferences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should healthcare providers include in decision making?. ### Response: patient-centered preferences.


Instruction: What has not been shown to be beneficial?

Output: Routine use of prophylactic antibiotics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has not been shown to be beneficial?. ### Response: Routine use of prophylactic antibiotics.


Instruction: How many large RCTs demonstrated no effect of preventive antimicrobial therapy on functional outcome?

Output: Two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many large RCTs demonstrated no effect of preventive antimicrobial therapy on functional outcome?. ### Response: Two.


Instruction: What study showed no difference in the primary end point of distribution of functional outcome scores on the mRS score at 3 months?

Output: Preventive Antibiotics in Stroke Study)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What study showed no difference in the primary end point of distribution of functional outcome scores on the mRS score at 3 months?. ### Response: Preventive Antibiotics in Stroke Study).


Instruction: What was the adjusted common OR of the Stroke Study?

Output: 0.95

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the adjusted common OR of the Stroke Study?. ### Response: 0.95.


Instruction: What was the OR of STROKE-INF?

Output: 0.95

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the OR of STROKE-INF?. ### Response: 0.95.


Instruction: What did the OR decrease in urinary tract infections?

Output: 0.34

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the OR decrease in urinary tract infections?. ### Response: 0.34.


Instruction: How was the rate of poststroke pneumonia reduced?

Output: no significant decrease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the rate of poststroke pneumonia reduced?. ### Response: no significant decrease.


Instruction: What did not affect the incidence of the primary end point of poststroke pneumonia?

Output: prophylactic antibiotics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did not affect the incidence of the primary end point of poststroke pneumonia?. ### Response: prophylactic antibiotics.


Instruction: What was the adjusted OR of prophylactic antibiotics at 90 days?

Output: 0.87

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the adjusted OR of prophylactic antibiotics at 90 days?. ### Response: 0.87.


Instruction: How many meta-analyses were included in the meta-analysis?

Output: Three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many meta-analyses were included in the meta-analysis?. ### Response: Three.


Instruction: How many meta-analyses showed a reduction in infection but no change in functional outcome?

Output: Three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many meta-analyses showed a reduction in infection but no change in functional outcome?. ### Response: Three.


Instruction: What should not be performed because of the associated risks?

Output: Routine placement of indwelling bladder catheters

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not be performed because of the associated risks?. ### Response: Routine placement of indwelling bladder catheters.


Instruction: Why should bladder catheters not be performed?

Output: associated risk of catheter-associated urinary tract infections

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why should bladder catheters not be performed?. ### Response: associated risk of catheter-associated urinary tract infections.


Instruction: What is the risk associated with catheter-associated urinary tract infections?

Output: Routine placement of indwelling bladder catheters should not be performed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk associated with catheter-associated urinary tract infections?. ### Response: Routine placement of indwelling bladder catheters should not be performed.


Instruction: What is the name of the registry used by the American Heart Association?

Output: sbhci

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the registry used by the American Heart Association?. ### Response: sbhci.


Instruction: When was the Catheter Cardiovasc Interv.84:912 – 22.21.

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Catheter Cardiovasc Interv.84:912 – 22.21.. ### Response: 2014.


Instruction: What was the outcome of the randomised trial?

Output: major adversecardiac events during long-term follow-up

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome of the randomised trial?. ### Response: major adversecardiac events during long-term follow-up.


Instruction: What is a major adversecardiac event?

Output: target-vessel versus multi-vessel revascularisationin ST-elevation myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a major adversecardiac event?. ### Response: target-vessel versus multi-vessel revascularisationin ST-elevation myocardial infarction.


Instruction: What type of intervention is used for acute myocardialinfarction?

Output: primary percutaneouscoronary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of intervention is used for acute myocardialinfarction?. ### Response: primary percutaneouscoronary.


Instruction: What is the name of the randomized trial of preventive angioplasty in ST-elevation patients?

Output: EXPIRA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized trial of preventive angioplasty in ST-elevation patients?. ### Response: EXPIRA.


Instruction: How is multivessel percutaneous coronary intervention performed?

Output: mechanical reperfusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is multivessel percutaneous coronary intervention performed?. ### Response: mechanical reperfusion.


Instruction: What is the name of the randomized trial of preventive angioplasty in myocardial infarction?

Output: EXPIRA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized trial of preventive angioplasty in myocardial infarction?. ### Response: EXPIRA.


Instruction: What are the results of the Randomized Angioplasty Trial?

Output: 53:309 –15.32

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of the Randomized Angioplasty Trial?. ### Response: 53:309 –15.32.


Instruction: What is the name of the condition that causes acute myocardial infarction?

Output: mul-tivessel disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the condition that causes acute myocardial infarction?. ### Response: mul-tivessel disease.


Instruction: When was the last time a patient had a primary PCI for STEMI?

Output: 1115 –23.25

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last time a patient had a primary PCI for STEMI?. ### Response: 1115 –23.25.


Instruction: What is a common cause of non-infarct-related coronary artery disease?

Output: ST-elevationmyocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a common cause of non-infarct-related coronary artery disease?. ### Response: ST-elevationmyocardial infarction.


Instruction: How is multivessel coronary disease diagnosed?

Output: at the time of primary PCI for STEMI: complete revas-cularization versus conservative strategy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is multivessel coronary disease diagnosed?. ### Response: at the time of primary PCI for STEMI: complete revas-cularization versus conservative strategy.


Instruction: What is the primary PCI for STEMI: complete revas-cularization versus conservative strategy?

Output: PRAGUE13 trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary PCI for STEMI: complete revas-cularization versus conservative strategy?. ### Response: PRAGUE13 trial.


Instruction: What is available at: http://sbhci.org.br/wp-content/uploads/2015/05/PR AGUE-13-Trial.pdf?

Output: PRAGUE13 trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is available at: http://sbhci.org.br/wp-content/uploads/2015/05/PR AGUE-13-Trial.pdf?. ### Response: PRAGUE13 trial.


Instruction: When was the PRAGUE13 trial available?

Output: September 10, 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the PRAGUE13 trial available?. ### Response: September 10, 2015.


Instruction: What is the name of the meta-analysis of patients with ST-segment elevation myocardialinfarction?

Output: pairwise and network

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis of patients with ST-segment elevation myocardialinfarction?. ### Response: pairwise and network.


Instruction: When was the J AmColl Cardiol. 2011 58:692-703.29?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J AmColl Cardiol. 2011 58:692-703.29?. ### Response: 2011.


Instruction: How long did the TAPAS follow-up study last?

Output: 1-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the TAPAS follow-up study last?. ### Response: 1-year.


Instruction: What is the name of the study that followed a 1-year follow-up?

Output: Acute myocardial infarction Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that followed a 1-year follow-up?. ### Response: Acute myocardial infarction Study.


Instruction: What does TAPAS stand for?

Output: Acute myocardial infarction Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does TAPAS stand for?. ### Response: Acute myocardial infarction Study.


Instruction: How long did the study last?

Output: 1-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the study last?. ### Response: 1-year.


Instruction: What improves myocardial reperfusion and reduces infarct size?

Output: Thrombus aspiration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What improves myocardial reperfusion and reduces infarct size?. ### Response: Thrombus aspiration.


Instruction: What is the EXPIRA?

Output: thrombectomy withexport catheter in infarct-related artery during primarypercutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the EXPIRA?. ### Response: thrombectomy withexport catheter in infarct-related artery during primarypercutaneous coronary intervention.


Instruction: What is thrombusaspiration during primary percutaneous coronary inter-vention?

Output: improves myocardial reperfusion andreduces infarct size

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is thrombusaspiration during primary percutaneous coronary inter-vention?. ### Response: improves myocardial reperfusion andreduces infarct size.


Instruction: What is aspirationthrombectomy bene ficial in patients undergoing?

Output: pri

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is aspirationthrombectomy bene ficial in patients undergoing?. ### Response: pri.


Instruction: What can be used in place of ficial income docu-mentation?

Output: come

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be used in place of ficial income docu-mentation?. ### Response: come.


Instruction: What do patients and clinicians need to be cognizant of?

Output: reordering procedures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do patients and clinicians need to be cognizant of?. ### Response: reordering procedures.


Instruction: What are not alwayssent if doses are changed?

Output: reﬁlls/reorders

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are not alwayssent if doses are changed?. ### Response: reﬁlls/reorders.


Instruction: Refills/reorders cannot berequested before what?

Output: 60-day post-approval date

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Refills/reorders cannot berequested before what?. ### Response: 60-day post-approval date.


Instruction: What provides product-speci fici n-formation on assistance in payment for newer HF thera-pies and appropriate use criteria to assist in the priorauthorization process?

Output: Supplemental Appendix 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What provides product-speci fici n-formation on assistance in payment for newer HF thera-pies and appropriate use criteria to assist in the priorauthorization process?. ### Response: Supplemental Appendix 2.


Instruction: What was the motivation behind the 2017 HF ECDP?

Output: an increasinglycomplex HFrEF management environment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the motivation behind the 2017 HF ECDP?. ### Response: an increasinglycomplex HFrEF management environment.


Instruction: How long has GDMT for HFrEF been published?

Output: 3 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long has GDMT for HFrEF been published?. ### Response: 3 years.


Instruction: What does HFrEF now have that improve patient outcomes?

Output: GDMT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does HFrEF now have that improve patient outcomes?. ### Response: GDMT.


Instruction: What is a strategy to reduce patients’ cost of caren?

Output: TABLE 12

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a strategy to reduce patients’ cost of caren?. ### Response: TABLE 12.


Instruction: What type of coverage is used when prescribing GDMT?

Output: generic equivalents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of coverage is used when prescribing GDMT?. ### Response: generic equivalents.


Instruction: Who can you work with to identify and navigate Patient Assistance Programs?

Output: pharmacist, social worker , or patient navigator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who can you work with to identify and navigate Patient Assistance Programs?. ### Response: pharmacist, social worker , or patient navigator.


Instruction: How much does a drug cost to be found at another pharmacy?

Output: lower

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much does a drug cost to be found at another pharmacy?. ### Response: lower.


Instruction: What is GDMT 14guideline-directed medical therapy?

Output: HFrEF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is GDMT 14guideline-directed medical therapy?. ### Response: HFrEF.


Instruction: What is included in HF phenotype?

Output: HFrEF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is included in HF phenotype?. ### Response: HFrEF.


Instruction: What is anappropriate rational for testing requests?

Output: clinical judgment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is anappropriate rational for testing requests?. ### Response: clinical judgment.


Instruction: What are known contraindications to use, adverse effects, and steps intended to minimize?

Output: the risks of drugs or procedures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are known contraindications to use, adverse effects, and steps intended to minimize?. ### Response: the risks of drugs or procedures.


Instruction: Do not hesitate to ap-peal decisions that are contrary to the best patient care?

Output: Work with local pharmacy resources and pharmacy professionals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Do not hesitate to ap-peal decisions that are contrary to the best patient care?. ### Response: Work with local pharmacy resources and pharmacy professionals.


Instruction: What type of patient care is best?

Output: clinical judgment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of patient care is best?. ### Response: clinical judgment.


Instruction: What may vary depending on payer and state?

Output: Required information

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may vary depending on payer and state?. ### Response: Required information.


Instruction: HF14heart failure with preserved ejection fraction; HFrEF 14Heart failure without reduced ejective fraction; NYHA 14,New heart failure; what type of heart failure?

Output: HF¼

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: HF14heart failure with preserved ejection fraction; HFrEF 14Heart failure without reduced ejective fraction; NYHA 14,New heart failure; what type of heart failure?. ### Response: HF¼.


Instruction: How many steps are taken in the patient?

Output: all

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many steps are taken in the patient?. ### Response: all.


Instruction: What is the LVEF 14left ventricular ejection fraction?

Output: ¼

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the LVEF 14left ventricular ejection fraction?. ### Response: ¼.


Instruction: What does NYHA stand for?

Output: New York Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does NYHA stand for?. ### Response: New York Heart Association.


Instruction: When was the JACC VOL. 77, NO. 6, 20212021 updated?

Output: FEBRUARY 16, 2021

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the JACC VOL. 77, NO. 6, 20212021 updated?. ### Response: FEBRUARY 16, 2021.


Instruction: What was the stroke risk for women taking or not taking warfarin?

Output: 0.7%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the stroke risk for women taking or not taking warfarin?. ### Response: 0.7%).


Instruction: What is the risk of stroke in women?

Output: 0.7%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of stroke in women?. ### Response: 0.7%).


Instruction: What was the HR adjusted for after adjustment for baseline comorbid conditions, individual components of the CHADS2 score, and warfarin treatment?

Output: increased risk of stroke in women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the HR adjusted for after adjustment for baseline comorbid conditions, individual components of the CHADS2 score, and warfarin treatment?. ### Response: increased risk of stroke in women.


Instruction: What was a signifi-cant (P =0.02) interaction of age with sex?

Output: 372

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a signifi-cant (P =0.02) interaction of age with sex?. ### Response: 372.


Instruction: What was the age-sex interaction on stroke risk in patients with AF confirmed in a large Swedish drug registry study?

Output: comparably low in both women (0.7%) and men (0.5%).

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the age-sex interaction on stroke risk in patients with AF confirmed in a large Swedish drug registry study?. ### Response: comparably low in both women (0.7%) and men (0.5%)..


Instruction: What was associated with greater stroke reduction in women (60%?

Output: warfarin use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with greater stroke reduction in women (60%?. ### Response: warfarin use.


Instruction: What was associated with greater stroke reduction in women than in men?

Output: warfarin use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with greater stroke reduction in women than in men?. ### Response: warfarin use.