Instruction: What year did Ann Intern Med issue 52:741–9?

Output: 1960

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Ann Intern Med issue 52:741–9?. ### Response: 1960.


Instruction: Who wrote the book Systemic embolism and Mitral Stenosis?

Output: Szekely P

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote the book Systemic embolism and Mitral Stenosis?. ### Response: Szekely P.


Instruction: What year did Intern Med publish a report on mitral stenosis?

Output: 1960

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Intern Med publish a report on mitral stenosis?. ### Response: 1960.


Instruction: What is the name of the disease that is associated with left atrial thrombi?

Output: mitral stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease that is associated with left atrial thrombi?. ### Response: mitral stenosis.


Instruction: In what year did Br Med J publish the report on rheumatic heart disease?

Output: 1964

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did Br Med J publish the report on rheumatic heart disease?. ### Response: 1964.


Instruction: Incidence of left atrial thrombi in patients with sinus rhythm and with a neurologic deficit.

Output: Am Heart J. 2000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Incidence of left atrial thrombi in patients with sinus rhythm and with a neurologic deficit.. ### Response: Am Heart J. 2000.


Instruction: What is the name of the study that investigated the incidence of left ventricular thrombo in sinus rhythm patients?

Output: ste-nosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the incidence of left ventricular thrombo in sinus rhythm patients?. ### Response: ste-nosis.


Instruction: In what year was the Am Heart J140:658-662 published?

Output: 2000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was the Am Heart J140:658-662 published?. ### Response: 2000.


Instruction: What was the effect of heart rate control on coagulation status in rheumatic mitral stenosis with atrial fibrillation?

Output: effort tolerance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the effect of heart rate control on coagulation status in rheumatic mitral stenosis with atrial fibrillation?. ### Response: effort tolerance.


Instruction: What is the coagulation status in patients of rheumatic mitral stenosis with atrial fibrillation?

Output: Effect of heart rate control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the coagulation status in patients of rheumatic mitral stenosis with atrial fibrillation?. ### Response: Effect of heart rate control.


Instruction: Indian Heart J. 2015;67(suppl 2):S40-5.

Output: 9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Indian Heart J. 2015;67(suppl 2):S40-5.. ### Response: 9.


Instruction: What does inadequate cardiac output reserve have an effect on?

Output: exercise tolerance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does inadequate cardiac output reserve have an effect on?. ### Response: exercise tolerance.


Instruction: Am J Cardiol. 1997;80:236-40.

Output: Effect of inadequate cardiac output reserve on exercise tolerance in patients with moderate mitral stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Am J Cardiol. 1997;80:236-40.. ### Response: Effect of inadequate cardiac output reserve on exercise tolerance in patients with moderate mitral stenosis.


Instruction: What is the name of the disease that causes mitral stenosis?

Output: exer -cise intolerance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease that causes mitral stenosis?. ### Response: exer -cise intolerance.


Instruction: What is one of the mechanisms of effort intoler-ance in patients with rheumatic mitral syndrome?

Output: inadequate cardiac output reserve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the mechanisms of effort intoler-ance in patients with rheumatic mitral syndrome?. ### Response: inadequate cardiac output reserve.


Instruction: How many patients were treated with combined echocardiog-raphy and cardiopulmonary stress protocol?

Output: 13

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with combined echocardiog-raphy and cardiopulmonary stress protocol?. ### Response: 13.


Instruction: What is ivabradine used for in patients with mild-to-moderate mitral stenosis?

Output: heart rate and effort tolerance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ivabradine used for in patients with mild-to-moderate mitral stenosis?. ### Response: heart rate and effort tolerance.


Instruction: What is the name of the drug used in a randomized comparison with metoprolol?

Output: ivabradine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used in a randomized comparison with metoprolol?. ### Response: ivabradine.


Instruction: What is ivabradine compared to atenolol in patients with mild-to-moderate mitral stenosis?

Output: heart rate and effort tolerance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ivabradine compared to atenolol in patients with mild-to-moderate mitral stenosis?. ### Response: heart rate and effort tolerance.


Instruction: What is the effect on heart rate and effort tolerance?

Output: Effect of ivabradine vs atenolol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect on heart rate and effort tolerance?. ### Response: Effect of ivabradine vs atenolol.


Instruction: When did J Card Fail. 2012:18:282–8.

Output: April 27, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J Card Fail. 2012:18:282–8.. ### Response: April 27, 2023.


Instruction: What causes mitral stenosis and normal sinus rhythm?

Output: left atrial thrombi

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes mitral stenosis and normal sinus rhythm?. ### Response: left atrial thrombi.


Instruction: When was J Card Fail published?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was J Card Fail published?. ### Response: 2012.


Instruction: What is the name of the author of CLINICAL St AteMeNtS ANd GuIdeLINeSHeart Failure Focused Update on Pharmacological TherapyCirculation. 2016;134:e282-e293. DOI: 10.1161/CIR.0000000000000435 September 27, 2016 e293José A. Joglar is a professor of what?

Output: José A. Joglar

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the author of CLINICAL St AteMeNtS ANd GuIdeLINeSHeart Failure Focused Update on Pharmacological TherapyCirculation. 2016;134:e282-e293. DOI: 10.1161/CIR.0000000000000435 September 27, 2016 e293José A. Joglar is a professor of what?. ### Response: José A. Joglar.


Instruction: Who is a professor of cardiology at Johns Hopkins?

Output: E. Cowles Andrus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a professor of cardiology at Johns Hopkins?. ### Response: E. Cowles Andrus.


Instruction: Who is the professor of medicine at the University of Washington?

Output: Wayne C. Levy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the professor of medicine at the University of Washington?. ### Response: Wayne C. Levy.


Instruction: Who is the Director/Heart Failure Center at SUNY Downstate Medical Center?

Output: Judith E. Mitchell

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Director/Heart Failure Center at SUNY Downstate Medical Center?. ### Response: Judith E. Mitchell.


Instruction: What is the name of the associate professor of medicine at the University of New York?

Output: Judith E. Mitchell

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the associate professor of medicine at the University of New York?. ### Response: Judith E. Mitchell.


Instruction: Who is a member of the American Heart Association?

Output: José A. Joglar

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a member of the American Heart Association?. ### Response: José A. Joglar.


Instruction: Who is a content reviewer for the ACC Heart Failure and Transplant Council at Mount Sinai School of Medicine?

Output: Randall C. Starling

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a content reviewer for the ACC Heart Failure and Transplant Council at Mount Sinai School of Medicine?. ### Response: Randall C. Starling.


Instruction: Who is a Content Reviewer for the ACC Heart Failure and Transplant Council?

Output: Randall C. Starling

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a Content Reviewer for the ACC Heart Failure and Transplant Council?. ### Response: Randall C. Starling.


Instruction: Who is the Vice Chairman of the Department of Cardiovascular Medicine?

Output: Randall C. Starling

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Vice Chairman of the Department of Cardiovascular Medicine?. ### Response: Randall C. Starling.


Instruction: What is the Section Head of Heart Failure & Cardiac Transplant?

Output: BioControl

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Section Head of Heart Failure & Cardiac Transplant?. ### Response: BioControl.


Instruction: Who is a Content Reviewer at the Cleveland Clinic Foundation?

Output: W. H. Wilson Tang

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a Content Reviewer at the Cleveland Clinic Foundation?. ### Response: W. H. Wilson Tang.


Instruction: Who is an Assistant Professor of Medicine?

Output: Judith E. Mitchell

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is an Assistant Professor of Medicine?. ### Response: Judith E. Mitchell.


Instruction: Where is Emily J. Tsai from?

Output: Columbia University College of Physicians & Surgeons

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Emily J. Tsai from?. ### Response: Columbia University College of Physicians & Surgeons.


Instruction: Who is a Content Reviewer for the ACC/AHA Task Force on Clinical Practice Guidelines?

Output: José A. Joglar

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a Content Reviewer for the ACC/AHA Task Force on Clinical Practice Guidelines?. ### Response: José A. Joglar.


Instruction: Where is Li Ka Shing Knowledge Institute based?

Output: St. Michael’s Hospital

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Li Ka Shing Knowledge Institute based?. ### Response: St. Michael’s Hospital.


Instruction: What is the title of the Assistant Professor at the University of Toronto?

Output: Department of Anesthesia and Institute of Health Policy Management and Evaluation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of the Assistant Professor at the University of Toronto?. ### Response: Department of Anesthesia and Institute of Health Policy Management and Evaluation.


Instruction: What is another name for the Heart and Stroke Foundation of Canada?

Output: CIHR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for the Heart and Stroke Foundation of Canada?. ### Response: CIHR.


Instruction: What does PCORI stand for?

Output: DSMB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does PCORI stand for?. ### Response: DSMB.


Instruction: What is the name of the organization that records the relationships of reviewers with industry and other entities?

Output: Myers Squib

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that records the relationships of reviewers with industry and other entities?. ### Response: Myers Squib.


Instruction: What percentage of a business is owned by a person who has a significant interest in it?

Output: ≥ 5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of a business is owned by a person who has a significant interest in it?. ### Response: ≥ 5%.


Instruction: How much of the business does the person have a substantial interest in?

Output: ≥ 5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the business does the person have a substantial interest in?. ### Response: ≥ 5%.


Instruction: What type of peptide is NT-proBNP?

Output: N -terminus pro -B-type natriuretic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of peptide is NT-proBNP?. ### Response: N -terminus pro -B-type natriuretic.


Instruction: What is B-type natriuretic Peptide?

Output: BNP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is B-type natriuretic Peptide?. ### Response: BNP.


Instruction: How many thresholds are there?

Output: 978 -1-4731

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many thresholds are there?. ### Response: 978 -1-4731.


Instruction: What peptides are most accurate in identifying heart failure?

Output: N -terminus pro -B-type natriuretic peptide (NT -proBNP) and B-type natriuretic peptide (BNP)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What peptides are most accurate in identifying heart failure?. ### Response: N -terminus pro -B-type natriuretic peptide (NT -proBNP) and B-type natriuretic peptide (BNP).


Instruction: What is the reference standard for NT-proBNP?

Output: N -terminus pro -B-type natriuretic peptide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the reference standard for NT-proBNP?. ### Response: N -terminus pro -B-type natriuretic peptide.


Instruction: What is the area under Curve 5 Diagnostic RCT?

Output: ROC curve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the area under Curve 5 Diagnostic RCT?. ### Response: ROC curve.


Instruction: What are the clinical and cost effectiveness of N -terminus pro -B-type natriuretic peptide?

Output: when each is followed by the appropriate patient pathway

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the clinical and cost effectiveness of N -terminus pro -B-type natriuretic peptide?. ### Response: when each is followed by the appropriate patient pathway.


Instruction: What is natriuretic peptide (BNP) used for?

Output: improve patient outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is natriuretic peptide (BNP) used for?. ### Response: improve patient outcomes.


Instruction: What are the Efficacy outcomes of BNP?

Output: All-cause mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Efficacy outcomes of BNP?. ### Response: All-cause mortality.


Instruction: How many people receive echocardiography?

Output: Number

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people receive echocardiography?. ### Response: Number.


Instruction: What is another term for people who may not have needed echocardiography?

Output: false positive results

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for people who may not have needed echocardiography?. ### Response: false positive results.


Instruction: What are the secondary outcomes of echocardiographic testing?

Output: Sensitivity / specificity and other test accuracy measures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the secondary outcomes of echocardiographic testing?. ### Response: Sensitivity / specificity and other test accuracy measures.


Instruction: What is the clinical and cost effectivenes s of cardiac MRI followed by the appropriate patient pathway?

Output: In people with heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the clinical and cost effectivenes s of cardiac MRI followed by the appropriate patient pathway?. ### Response: In people with heart failure.


Instruction: What are the critical outcomes?

Output: All-cause mortality (time to event)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the critical outcomes?. ### Response: All-cause mortality (time to event).


Instruction: How long is the health-related quality of life?

Output: 12

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the health-related quality of life?. ### Response: 12.


Instruction: How long is the quality of life at 12 months?

Output: continuous

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the quality of life at 12 months?. ### Response: continuous.


Instruction: What is the term for unplanned hospitalisation?

Output: Count rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for unplanned hospitalisation?. ### Response: Count rate.


Instruction: Adverse events related to test?

Output: non -specific fibrosis in the presence of renal dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Adverse events related to test?. ### Response: non -specific fibrosis in the presence of renal dysfunction.


Instruction: Reclassification of specific HF aetiology includes ability to classify previous unclassified patients?

Output: Adverse events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Reclassification of specific HF aetiology includes ability to classify previous unclassified patients?. ### Response: Adverse events.


Instruction: What is specific HF aetiology?

Output: ability to classify previous unclassified patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is specific HF aetiology?. ### Response: ability to classify previous unclassified patients.


Instruction: What is the ability to classify previous unclassified patients?

Output: HF aetiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ability to classify previous unclassified patients?. ### Response: HF aetiology.


Instruction: What is the clinical and cost effectiveness of salt and/or fluid restriction in people with heart failure?

Output: Repeat testing / additional testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the clinical and cost effectiveness of salt and/or fluid restriction in people with heart failure?. ### Response: Repeat testing / additional testing.


Instruction: How long is the quality of life at 12 months (Continuous)?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the quality of life at 12 months (Continuous)?. ### Response: .


Instruction: What did Hall G, Heimdahl A, Nord CE, do after dental extraction?

Output: prophylactic administration ofcefaclor on transient bacteremia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Hall G, Heimdahl A, Nord CE, do after dental extraction?. ### Response: prophylactic administration ofcefaclor on transient bacteremia.


Instruction: What was the effect of prophylactic administration ofcefaclor on?

Output: transient bacteremia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the effect of prophylactic administration ofcefaclor on?. ### Response: transient bacteremia.


Instruction: When was the Eur J ClinMicrobiol Infect Dis 15:646–649.78?

Output: 1995

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Eur J ClinMicrobiol Infect Dis 15:646–649.78?. ### Response: 1995.


Instruction: What is the role of antiseptics and antibiotics in post-extraction bacter-aemia?

Output: role

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of antiseptics and antibiotics in post-extraction bacter-aemia?. ### Response: role.


Instruction: What is Oliver R, Roberts GJ, Hooper L. Penicillins for the prophylaxis of bacterial endocarditis in dentistry?

Output: cost-effective

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Oliver R, Roberts GJ, Hooper L. Penicillins for the prophylaxis of bacterial endocarditis in dentistry?. ### Response: cost-effective.


Instruction: How important are dental procedures as a cause ofinfective endocarditis?

Output: Estimated risk of endocarditis in adults with predisposingcardiac conditions undergoing dental procedures with or without anti-biotic prophylaxis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How important are dental procedures as a cause ofinfective endocarditis?. ### Response: Estimated risk of endocarditis in adults with predisposingcardiac conditions undergoing dental procedures with or without anti-biotic prophylaxis.


Instruction: What year did Am J Cardiol 54:797–801.82?

Output: 1984

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Am J Cardiol 54:797–801.82?. ### Response: 1984.


Instruction: Where was Medicine (Baltimore) published in 1977?

Output: 56:61–77.83

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where was Medicine (Baltimore) published in 1977?. ### Response: 56:61–77.83.


Instruction: Horstkotte D, Rosin H, Friedrichs W, Loogen F. Contribution forchoosing the optimal prophylaxis of what?

Output: bacterial endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Horstkotte D, Rosin H, Friedrichs W, Loogen F. Contribution forchoosing the optimal prophylaxis of what?. ### Response: bacterial endocarditis.


Instruction: What was Loogen F's role in choosing the optimal prophylaxis of bacterial endocarditis?

Output: Contribution

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was Loogen F's role in choosing the optimal prophylaxis of bacterial endocarditis?. ### Response: Contribution.


Instruction: What is the name of the study that evaluated protective efficacy?

Output: Am J Med

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated protective efficacy?. ### Response: Am J Med.


Instruction: In what year was the Am J Med published?

Output: 1990

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was the Am J Med published?. ### Response: 1990.


Instruction: Who was the author of The Epidemiology of Bacterial Endocarditic Disease?

Output: enburg HA, Michel MF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the author of The Epidemiology of Bacterial Endocarditic Disease?. ### Response: enburg HA, Michel MF.


Instruction: What is the epidemiology of bacterial endocarditis in The Netherlands?

Output: II: antecedent pro-cedures and use of prophylaxis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the epidemiology of bacterial endocarditis in The Netherlands?. ### Response: II: antecedent pro-cedures and use of prophylaxis.


Instruction: What are the antecedent pro-cedures and use of prophylaxis?

Output: Epidemi-ology of bacterial endocarditis in The Netherlands, II

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the antecedent pro-cedures and use of prophylaxis?. ### Response: Epidemi-ology of bacterial endocarditis in The Netherlands, II.


Instruction: When was the Arch Intern Med published?

Output: 1992

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Arch Intern Med published?. ### Response: 1992.


Instruction: What is a prophylaxis for prevention of?

Output: bacterial endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a prophylaxis for prevention of?. ### Response: bacterial endocarditis.


Instruction: What is the name of the disease that causes native-valve endocarditis?

Output: bacterial endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease that causes native-valve endocarditis?. ### Response: bacterial endocarditis.


Instruction: What is the risk of endocarditis in adults with predisposingcardiac conditions undergoing dental procedures with or without anti-biotic prophylaxis?

Output: Estimated risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of endocarditis in adults with predisposingcardiac conditions undergoing dental procedures with or without anti-biotic prophylaxis?. ### Response: Estimated risk.


Instruction: What was the “incubation period” of sub-acute bacterial infection?

Output: Post-extraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the “incubation period” of sub-acute bacterial infection?. ### Response: Post-extraction.


Instruction: Durack D, Beeson P. What is the “incubation period” of sub-acute bacterial endocarditis?

Output: Clin Infect Dis . 2006;42:e102–e107.89

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Durack D, Beeson P. What is the “incubation period” of sub-acute bacterial endocarditis?. ### Response: Clin Infect Dis . 2006;42:e102–e107.89.


Instruction: What year did Yale J Biol Med publish 50:49–58.90?

Output: 1977

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Yale J Biol Med publish 50:49–58.90?. ### Response: 1977.


Instruction: Steckelberg JM, Wilson WR. Risk factors for what?

Output: infective endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Steckelberg JM, Wilson WR. Risk factors for what?. ### Response: infective endocarditis.


Instruction: Pallasch TJ, Wahl MJ. Focal infection: new age or ancient history?

Output: new

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Pallasch TJ, Wahl MJ. Focal infection: new age or ancient history?. ### Response: new.


Instruction: What year did Endodontic Topics publish?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Endodontic Topics publish?. ### Response: 2003.


Instruction: What is the name of the journal that examined the history of endodontics in 2003?

Output: Endodontic Topics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that examined the history of endodontics in 2003?. ### Response: Endodontic Topics.


Instruction: How many people died from anaphylactic shock in 1968?

Output: 38:159–188.93

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people died from anaphylactic shock in 1968?. ### Response: 38:159–188.93.


Instruction: When was the Bull World Health Organ published?

Output: 1968

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Bull World Health Organ published?. ### Response: 1968.


Instruction: What year was Allergy.39:151–164.94?

Output: 1984

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was Allergy.39:151–164.94?. ### Response: 1984.


Instruction: What is the cost-effectiveness of antibiotic prophylaxis for bac-terial endocarditis?

Output: Efficacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cost-effectiveness of antibiotic prophylaxis for bac-terial endocarditis?. ### Response: Efficacy.


Instruction: What is the level of evidence for statins in NSTE-ACS patients?

Output: C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the level of evidence for statins in NSTE-ACS patients?. ### Response: C.


Instruction: How long after presentation is it reasonable to obtain a fasting lipid profile?

Output: 24 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after presentation is it reasonable to obtain a fasting lipid profile?. ### Response: 24 hours.


Instruction: What does statin therapy reduce?

Output: the rate of recurrent MI, coronary heart disease mortality, need for myocardial revascularization, and stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does statin therapy reduce?. ### Response: the rate of recurrent MI, coronary heart disease mortality, need for myocardial revascularization, and stroke.


Instruction: MI, need for myocardial revascularization, and stroke?

Output: coronary heart disease mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: MI, need for myocardial revascularization, and stroke?. ### Response: coronary heart disease mortality.


Instruction: High-risk patients, such as those with NSTE-ACS, derive more benefit from what?

Output: high-intensity statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: High-risk patients, such as those with NSTE-ACS, derive more benefit from what?. ### Response: high-intensity statins.


Instruction: What lowers low-density lipoprotein cholesterol levels by 50%?

Output: atorvastatin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What lowers low-density lipoprotein cholesterol levels by 50%?. ### Response: atorvastatin.


Instruction: What is PROVE IT-TIMI 22?

Output: Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PROVE IT-TIMI 22?. ### Response: Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction.


Instruction: What is MIRACL?

Output: Myocardial Ischemia Reduction With Acute Cholesterol Lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is MIRACL?. ### Response: Myocardial Ischemia Reduction With Acute Cholesterol Lowering.


Instruction: What can early introduction of this approach promote?

Output: improved compliance with this regimen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can early introduction of this approach promote?. ### Response: improved compliance with this regimen.


Instruction: What should be started and continued indefinitely in all patients with LVEF less than 0.40?

Output: ACE inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be started and continued indefinitely in all patients with LVEF less than 0.40?. ### Response: ACE inhibitors.


Instruction: What is recommended in patients with HF or MI with LVEF less than 0.40 who are ACE inhibitor in-tolerant?

Output: ARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended in patients with HF or MI with LVEF less than 0.40 who are ACE inhibitor in-tolerant?. ### Response: ARBs.


Instruction: What is recommended in patients post-MI without renal dysfunction or hyperkalemia?

Output: Aldosterone blockade

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended in patients post-MI without renal dysfunction or hyperkalemia?. ### Response: Aldosterone blockade.


Instruction: What is the LVEF 0.40 or less?

Output: diabetes mellitus, or HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the LVEF 0.40 or less?. ### Response: diabetes mellitus, or HF.


Instruction: What is the level of evidence that ARBs are reasonable in other patients with cardiac or other vascular disease who are ACE inhibitor in-tolerant?

Output: 280

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the level of evidence that ARBs are reasonable in other patients with cardiac or other vascular disease who are ACE inhibitor in-tolerant?. ### Response: 280.


Instruction: What may be reasonable in all other patients with cardiac or other vascular disease?

Output: ACE inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be reasonable in all other patients with cardiac or other vascular disease?. ### Response: ACE inhibitors.


Instruction: What does ACE inhibitors reduce mortality in patients with recent MI?

Output: LV dysfunction (LVEF <0.40) with or without pulmonary congestion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ACE inhibitors reduce mortality in patients with recent MI?. ### Response: LV dysfunction (LVEF <0.40) with or without pulmonary congestion.


Instruction: What percentage of patients with NSTEMI develop HF during hospitalization?

Output: 15%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients with NSTEMI develop HF during hospitalization?. ### Response: 15%.


Instruction: What is the rate of HF in patients with diabetes mellitus 1 year later?

Output: 24%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the rate of HF in patients with diabetes mellitus 1 year later?. ### Response: 24%.


Instruction: How much benefit did a metaanalysis show from early initiation of an ACE inhibitor?

Output: 0.48%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much benefit did a metaanalysis show from early initiation of an ACE inhibitor?. ### Response: 0.48%).


Instruction: How long after admission for AMI was the benefit seen?

Output: 24 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after admission for AMI was the benefit seen?. ### Response: 24 hours.


Instruction: What should be used cautiously?

Output: An ACE inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be used cautiously?. ### Response: An ACE inhibitor.


Instruction: What should be used cautiously in the Downloaded from http://ahajournals.org by on April 28, 2023?

Output: An ACE inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be used cautiously in the Downloaded from http://ahajournals.org by on April 28, 2023?. ### Response: An ACE inhibitor.


Instruction: What should be provided to maintain oxygen saturation >94%?

Output: Supplemental oxygen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be provided to maintain oxygen saturation >94%?. ### Response: Supplemental oxygen.


Instruction: What is not recommended in nonhypoxic patients hospitalized with AIS?

Output: Supplemental oxygen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended in nonhypoxic patients hospitalized with AIS?. ### Response: Supplemental oxygen.


Instruction: Why was No BenefitB-RRecommendation reworded?

Output: for clarity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was No BenefitB-RRecommendation reworded?. ### Response: for clarity.


Instruction: What year was the 2013 AIS Guidelines reworded?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the 2013 AIS Guidelines reworded?. ### Response: 2015.


Instruction: What year were COR and LOE amended to conform with the 2015 Recommendation Classification System?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year were COR and LOE amended to conform with the 2015 Recommendation Classification System?. ### Response: 2013.


Instruction: How many participants were randomized within 24 hours of admission to the 2013 AIS Guidelines?

Output: 8003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many participants were randomized within 24 hours of admission to the 2013 AIS Guidelines?. ### Response: 8003.


Instruction: What was the baseline O2 saturation at 90 days of oxygen by nasal cannula at 2 L/min?

Output: >93%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the baseline O2 saturation at 90 days of oxygen by nasal cannula at 2 L/min?. ### Response: >93%).


Instruction: How long did it take for a participant to breathe continuously for 72 hours?

Output: 2 L/min (baseline O2 saturation >93%) or 3 L/min (baseline O2 saturation ≤93%) continuously for 72 hours or nocturnally for 3 nights

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for a participant to breathe continuously for 72 hours?. ### Response: 2 L/min (baseline O2 saturation >93%) or 3 L/min (baseline O2 saturation ≤93%) continuously for 72 hours or nocturnally for 3 nights.


Instruction: What is the baseline O2 saturation?

Output: >93%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the baseline O2 saturation?. ### Response: >93%).


Instruction: How long is 3 L/min continuously for 72 hours or nocturnally for 3 nights?

Output: 2 L/min (baseline O2 saturation >93%) or 3 L/min (baseline O2 saturation ≤93%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is 3 L/min continuously for 72 hours or nocturnally for 3 nights?. ### Response: 2 L/min (baseline O2 saturation >93%) or 3 L/min (baseline O2 saturation ≤93%).


Instruction: When was the online Data Supplement 1 downloaded?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the online Data Supplement 1 downloaded?. ### Response: April 28, 2023.


Instruction: Potency, receptor-binding characteristics, tissue distribution,metabolism, and excretion properties are what?

Output: there is little evidencethat these differences are associated with therapeutic advan-tages

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Potency, receptor-binding characteristics, tissue distribution,metabolism, and excretion properties are what?. ### Response: there is little evidencethat these differences are associated with therapeutic advan-tages.


Instruction: The benefits of ACE inhibitors seem to reflect what class effect?

Output: BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The benefits of ACE inhibitors seem to reflect what class effect?. ### Response: BP.


Instruction: What can the selection of a particular agent be based on?

Output: availability in local formularies, cost, andtolerability

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can the selection of a particular agent be based on?. ### Response: availability in local formularies, cost, andtolerability.


Instruction: What is recommended for all patients with SIHD and hypertension?

Output: ACE inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for all patients with SIHD and hypertension?. ### Response: ACE inhibitors.


Instruction: What are ACE inhibitors recommended for?

Output: all patients withSIHD and hypertension, diabetes mellitus, LV dysfunction(EF /H1134940%), or CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are ACE inhibitors recommended for?. ### Response: all patients withSIHD and hypertension, diabetes mellitus, LV dysfunction(EF /H1134940%), or CKD.


Instruction: Who were participants in the HOPE301 orEUROPA296trials?

Output: participants who did not have one ofthese conditions but did have multiple cardiac risk factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who were participants in the HOPE301 orEUROPA296trials?. ### Response: participants who did not have one ofthese conditions but did have multiple cardiac risk factors.


Instruction: What do ARBs do in a competitive or insurmountable manner to thetype 1 angiotensin II receptor?

Output: bind

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do ARBs do in a competitive or insurmountable manner to thetype 1 angiotensin II receptor?. ### Response: bind.


Instruction: What increases plasma reninactivity?

Output: 797ARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What increases plasma reninactivity?. ### Response: 797ARBs.


Instruction: What are the renin and angiotensin I and II concentra-tions?

Output: plasma renin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the renin and angiotensin I and II concentra-tions?. ### Response: plasma renin.


Instruction: What do ARBs produce in patients with hypertension or cardiovascular disease?

Output: reductions in BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do ARBs produce in patients with hypertension or cardiovascular disease?. ### Response: reductions in BP.


Instruction: Which agents significantly reduce LVmass and stroke incidences compared with beta blockers?

Output: ARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which agents significantly reduce LVmass and stroke incidences compared with beta blockers?. ### Response: ARBs.


Instruction: How many trials com-pared the effects of ACE inhibitors and ARBs on majorvascular events by BP effects?

Output: 26

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many trials com-pared the effects of ACE inhibitors and ARBs on majorvascular events by BP effects?. ### Response: 26.


Instruction: Treatment with ACE inhib-itor-based regimens was associated with a reduction in therisk for stroke by 19%, IHD by 16%, and heart failure by 27%?

Output: riskof stroke, IHD, and heart failure for each 5–mm Hg reductionin BP. When these outcomes were assessed at zero BPreduction, the risk reduction for IHD was significantly greaterfor ACE inhibitors than for ARBs (P/H110050.002). Furthermore,unlike ARBs, ACE inhibitors were associated with a signif-icant additional risk reduction for IHD of 9% ( P/H110050.004),without differences seen for stroke or heart failure versusARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Treatment with ACE inhib-itor-based regimens was associated with a reduction in therisk for stroke by 19%, IHD by 16%, and heart failure by 27%?. ### Response: riskof stroke, IHD, and heart failure for each 5–mm Hg reductionin BP. When these outcomes were assessed at zero BPreduction, the risk reduction for IHD was significantly greaterfor ACE inhibitors than for ARBs (P/H110050.002). Furthermore,unlike ARBs, ACE inhibitors were associated with a signif-icant additional risk reduction for IHD of 9% ( P/H110050.004),without differences seen for stroke or heart failure versusARBs.


Instruction: What was the reduction in risk for ARBs?

Output: 26%, 17%,and 12%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the reduction in risk for ARBs?. ### Response: 26%, 17%,and 12%,.


Instruction: What were the reductions in the risk of stroke, IHD, and heart failure for each 5mm Hg reduction in BP?

Output: –based regimens

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the reductions in the risk of stroke, IHD, and heart failure for each 5mm Hg reduction in BP?. ### Response: –based regimens.


Instruction: What was the risk reduction for IHD greater for ACE inhibitors than for ARBs?

Output: zero BPreduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk reduction for IHD greater for ACE inhibitors than for ARBs?. ### Response: zero BPreduction.


Instruction: What was a signifi-cant additional risk reductionfor IHD of 9%?

Output: ACE inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a signifi-cant additional risk reductionfor IHD of 9%?. ### Response: ACE inhibitors.


Instruction: What is the additional risk reduction for IHD?

Output: 9%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the additional risk reduction for IHD?. ### Response: 9%.


Instruction: What is recommended to be substituted for ACE inhibitors in patients with SIHD and hypertension?

Output: ARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended to be substituted for ACE inhibitors in patients with SIHD and hypertension?. ### Response: ARBs.


Instruction: What is recommended for patients with SIHD?

Output: ACE inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for patients with SIHD?. ### Response: ACE inhibitors.


Instruction: What contributes to a higher risk formortality and hospitalization?

Output: Influenza VaccinationClass I1. An annual influenza vaccine is recommended for patientswith SIHD.806–810 (Level of Evidence: B )In patients with chronic medical conditions such as cardio-vascular disease, influenza

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What contributes to a higher risk formortality and hospitalization?. ### Response: Influenza VaccinationClass I1. An annual influenza vaccine is recommended for patientswith SIHD.806–810 (Level of Evidence: B )In patients with chronic medical conditions such as cardio-vascular disease, influenza.


Instruction: Who recommends annual vaccination with inactivatedvaccine?

Output: The World Health Organization and theAHA/ACCF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who recommends annual vaccination with inactivatedvaccine?. ### Response: The World Health Organization and theAHA/ACCF.


Instruction: What does the AHA/ACCF recommend to prevent seasonal influenza?

Output: annual vaccination with inactivatedvaccine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the AHA/ACCF recommend to prevent seasonal influenza?. ### Response: annual vaccination with inactivatedvaccine.


Instruction: What is inactivatedvaccine administered intramuscularly?

Output: against seasonal in-fluenza

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is inactivatedvaccine administered intramuscularly?. ### Response: against seasonal in-fluenza.


Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart DiseaseFebruary 2, 2021 Circulation. 2021;143:e72–e227What is an important distinction in injectable drug users?

Output: endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart DiseaseFebruary 2, 2021 Circulation. 2021;143:e72–e227What is an important distinction in injectable drug users?. ### Response: endocarditis.


Instruction: What is extremely difficult to cure?

Output: Abscess in native valve endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is extremely difficult to cure?. ### Response: Abscess in native valve endocarditis.


Instruction: What are fungi, enterococci, and gram-positive cocci extremely difficult to cure with medical therapy alone?

Output: pathogens

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are fungi, enterococci, and gram-positive cocci extremely difficult to cure with medical therapy alone?. ### Response: pathogens.


Instruction: What is prone to abscess or fistula for -mation and other cardiac tissue destruction?

Output: Pseudomonas aeruginosa, Brucella, fungi, enterococci, and gram-positive cocci

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is prone to abscess or fistula for -mation and other cardiac tissue destruction?. ### Response: Pseudomonas aeruginosa, Brucella, fungi, enterococci, and gram-positive cocci.


Instruction: The mortality rate is significantly lower in patients treated with antifungal agents combined with what?

Output: surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The mortality rate is significantly lower in patients treated with antifungal agents combined with what?. ### Response: surgery.


Instruction: What is a life-threatening complication that cannot be cured with antibiotic therapy alone?

Output: Abscess in native valve endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a life-threatening complication that cannot be cured with antibiotic therapy alone?. ### Response: Abscess in native valve endocarditis.


Instruction: What percentage of patients treated with antifungal agents combined with surgery had an abscess in native valve endocarditis?

Output: 42%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients treated with antifungal agents combined with surgery had an abscess in native valve endocarditis?. ### Response: 42%.


Instruction: What are abscesses and destructive penetrating lesions called?

Output: fistulae

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are abscesses and destructive penetrating lesions called?. ### Response: fistulae.


Instruction: What is the mortality rate of 40% and heart block associated with?

Output: Extensive para-valvular infections

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the mortality rate of 40% and heart block associated with?. ### Response: Extensive para-valvular infections.


Instruction: The long-term results of surgery are what?

Output: very satisfactory

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The long-term results of surgery are what?. ### Response: very satisfactory.


Instruction: At 5 years, what is the actuarial survival rate?

Output: 75%±6%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: At 5 years, what is the actuarial survival rate?. ### Response: 75%±6%.


Instruction: What percentage of patients have prosthetic valve endocarditis at 8 years old?

Output: 76%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients have prosthetic valve endocarditis at 8 years old?. ### Response: 76%.


Instruction: What are the surgical results related to more than the type of valve used for a replacement?

Output: a surgeon’s ability to remove all infected tissues and recon-struct functional anatomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the surgical results related to more than the type of valve used for a replacement?. ### Response: a surgeon’s ability to remove all infected tissues and recon-struct functional anatomy.


Instruction: What type of valve endocarditis is complicated by paravalvular invasion?

Output: prosthetic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of valve endocarditis is complicated by paravalvular invasion?. ### Response: prosthetic.


Instruction: What is the surgical survival rate in high-risk group?

Output: 71%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the surgical survival rate in high-risk group?. ### Response: 71%.


Instruction: How many patients have reported surgical survival rates?

Output: 71%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients have reported surgical survival rates?. ### Response: 71%.


Instruction: What is the surgical survival rate in this high-risk group?

Output: 71%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the surgical survival rate in this high-risk group?. ### Response: 71%.


Instruction: Blood culture samples will typically become nega-tive after how many hours of appropriate antimicrobial therapy?

Output: 48

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Blood culture samples will typically become nega-tive after how many hours of appropriate antimicrobial therapy?. ### Response: 48.


Instruction: What may take up to a week for cultures to become negative?

Output: methicillin-resistant S. aureus and other resistant organisms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may take up to a week for cultures to become negative?. ### Response: methicillin-resistant S. aureus and other resistant organisms.


Instruction: How long does it take for cultures to become negative?

Output: up to a week

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take for cultures to become negative?. ### Response: up to a week.


Instruction: Why is caution advised in patients who develop recurrent fever after an initial successful response to antibiotics?

Output: the fever could be explained by reasons other than the endocarditic valve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is caution advised in patients who develop recurrent fever after an initial successful response to antibiotics?. ### Response: the fever could be explained by reasons other than the endocarditic valve.


Instruction: What is common with aggressive microorganisms resulting in infection?

Output: abscess or fistula for -mation and other cardiac tissue destruction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is common with aggressive microorganisms resulting in infection?. ### Response: abscess or fistula for -mation and other cardiac tissue destruction.


Instruction: What is common with aggressive microorganisms?

Output: abscess formation, valve destruction, fistulas, or large vegetations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is common with aggressive microorganisms?. ### Response: abscess formation, valve destruction, fistulas, or large vegetations.


Instruction: What results in abscess formation, valve destruction, fistulas, or large vegetations? What is the optimal therapy for cardiac device IE?

Output: aggressive microorganisms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What results in abscess formation, valve destruction, fistulas, or large vegetations? What is the optimal therapy for cardiac device IE?. ### Response: aggressive microorganisms.


Instruction: What does ICE-PCS stand for?

Output: International Collaboration on Endocarditis–Prospective Cohort Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ICE-PCS stand for?. ### Response: International Collaboration on Endocarditis–Prospective Cohort Study.


Instruction: What is the name of the prospective cohort study that showed high rates of concomitant valve infection and mortality among cardiac device IE patients?

Output: ICE-PCS (International Collaboration on Endocarditis–Prospective Cohort Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective cohort study that showed high rates of concomitant valve infection and mortality among cardiac device IE patients?. ### Response: ICE-PCS (International Collaboration on Endocarditis–Prospective Cohort Study.


Instruction: What are the risks of concomitant valve infection and mortality?

Output: high

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the risks of concomitant valve infection and mortality?. ### Response: high.


Instruction: If there is valve infection, what is the risk?

Output: mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: If there is valve infection, what is the risk?. ### Response: mortality.


Instruction: What are risk scores used for predicting using electronic health record data?

Output: cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are risk scores used for predicting using electronic health record data?. ### Response: cardiovascular events.


Instruction: What is the J Am Heart Assoc. 2017:6:e003670.

Output: electronic health record data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the J Am Heart Assoc. 2017:6:e003670.. ### Response: electronic health record data.


Instruction: What are the validation of the atherosclerotic cardiovascular disease pooled cohort risk equations?

Output: ACC/AHA 2013 pooled cohort equations compared to a Korean Risk Prediction Model

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the validation of the atherosclerotic cardiovascular disease pooled cohort risk equations?. ### Response: ACC/AHA 2013 pooled cohort equations compared to a Korean Risk Prediction Model.


Instruction: What did Colantonio LD, Richman JS, Carson AP, et al. perform by social deprivation status?

Output: atherosclerotic cardiovascular disease pooled cohort risk equations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Colantonio LD, Richman JS, Carson AP, et al. perform by social deprivation status?. ### Response: atherosclerotic cardiovascular disease pooled cohort risk equations.


Instruction: What did Crowson CS, Gabriel SE, Semb AG, and others say are not superior to?

Output: general risk scores

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Crowson CS, Gabriel SE, Semb AG, and others say are not superior to?. ### Response: general risk scores.


Instruction: What are risk scores not superior to?

Output: general risk scores

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are risk scores not superior to?. ### Response: general risk scores.


Instruction: How many countries did the validation analysis of patients from?

Output: seven

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many countries did the validation analysis of patients from?. ### Response: seven.


Instruction: What is the name of the organization that studies the validity of risk scores?

Output: Women’s Health Initiative

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that studies the validity of risk scores?. ### Response: Women’s Health Initiative.


Instruction: What is the name of the ret-rospective cohort study?

Output: Dalton JE, Perzynski AT, Zidar DA, et al. Accuracy of cardiovascular risk prediction varies by neighborhood socioeconomic position

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the ret-rospective cohort study?. ### Response: Dalton JE, Perzynski AT, Zidar DA, et al. Accuracy of cardiovascular risk prediction varies by neighborhood socioeconomic position.


Instruction: How many people were enrolled in the 2017 Ann Intern Med Study?

Output: 456–64

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were enrolled in the 2017 Ann Intern Med Study?. ### Response: 456–64.


Instruction: What did Mora S, Wenger NK, Cook NR, et al. evaluate for cardiovascular risk prediction in a multi-ethnic cohort?

Output: pooled cohort risk equations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Mora S, Wenger NK, Cook NR, et al. evaluate for cardiovascular risk prediction in a multi-ethnic cohort?. ### Response: pooled cohort risk equations.


Instruction: What project predicts the 10-year risks of athero-sclerotic cardiovascular disease in Chinese population?

Output: China-PAR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What project predicts the 10-year risks of athero-sclerotic cardiovascular disease in Chinese population?. ### Response: China-PAR.


Instruction: What is the China-PAR project?

Output: Prediction for ASCVD Risk in China

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the China-PAR project?. ### Response: Prediction for ASCVD Risk in China.


Instruction: What did the ACC/AHA 2013 pooled cohort equations compare to?

Output: Korean Risk Prediction Model for athero-sclerotic cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the ACC/AHA 2013 pooled cohort equations compare to?. ### Response: Korean Risk Prediction Model for athero-sclerotic cardiovascular disease.


Instruction: What was the Korean Risk Prediction Model for?

Output: athero-sclerotic cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the Korean Risk Prediction Model for?. ### Response: athero-sclerotic cardiovascular disease.


Instruction: Atherosclerosis. 2015;242:367–75.

Output: S2.2-55

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atherosclerosis. 2015;242:367–75.. ### Response: S2.2-55.


Instruction: What is the general cardiovascu-lar risk profile for use in primary care?

Output: Framingham Heart Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the general cardiovascu-lar risk profile for use in primary care?. ### Response: Framingham Heart Study.


Instruction: What is the name of the study that examined the cardiovascular risk in women?

Output: the Reynolds Risk Score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined the cardiovascular risk in women?. ### Response: the Reynolds Risk Score.


Instruction: What is one of the algorithms developed and validated for the assessment of global cardiovascular risk?

Output: Reynolds Risk Score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the algorithms developed and validated for the assessment of global cardiovascular risk?. ### Response: Reynolds Risk Score.


Instruction: When was the Reynolds Risk Score published?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Reynolds Risk Score published?. ### Response: 2007.


Instruction: What does C-reactive protein and parental history improve global cardiovascular risk prediction?

Output: the Reynolds Risk Score for men

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does C-reactive protein and parental history improve global cardiovascular risk prediction?. ### Response: the Reynolds Risk Score for men.


Instruction: What is the Reynolds Risk Score for men?

Output: C-reactive protein and parental history improve global cardiovascular risk prediction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Reynolds Risk Score for men?. ### Response: C-reactive protein and parental history improve global cardiovascular risk prediction.


Instruction: When did Circulation. 2008,118:2243-51; 4p following 2251?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circulation. 2008,118:2243-51; 4p following 2251?. ### Response: 2008.


Instruction: Who wrote the 2016 ESC/EAS guidelines for the management of dyslipidaemias?

Output: Catapano AL, Graham I, De Backer G

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote the 2016 ESC/EAS guidelines for the management of dyslipidaemias?. ### Response: Catapano AL, Graham I, De Backer G.


Instruction: What is the JBS3 Board's consensus recommendation for the prevention of cardiovascular disease?

Output: Joint British Societies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the JBS3 Board's consensus recommendation for the prevention of cardiovascular disease?. ### Response: Joint British Societies.


Instruction: What are the 2016 Canadian Cardiovascular Society guidelines for the management of?

Output: dyslipidaemias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the 2016 Canadian Cardiovascular Society guidelines for the management of?. ### Response: dyslipidaemias.


Instruction: What are the guidelines for the management of dyslipid-emia for the prevention of cardiovascular disease in the adult?

Output: ESC/EAS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the guidelines for the management of dyslipid-emia for the prevention of cardiovascular disease in the adult?. ### Response: ESC/EAS.


Instruction: What is a synopsis of the 2014 US Department of Veterans Affairs and Department of Defense clinical practice?

Output: Management of dyslipidemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a synopsis of the 2014 US Department of Veterans Affairs and Department of Defense clinical practice?. ### Response: Management of dyslipidemia.


Instruction: How are the statements reviewed by the Task Force?

Output: during each conference call and/or meetingof the writing committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are the statements reviewed by the Task Force?. ### Response: during each conference call and/or meetingof the writing committee.


Instruction: Who reviews the statements during each conference call and/or meeting?

Output: the Task Forceand all members

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who reviews the statements during each conference call and/or meeting?. ### Response: the Task Forceand all members.


Instruction: What must be approved by the voting members?

Output: guideline recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must be approved by the voting members?. ### Response: guideline recommendations.


Instruction: How are members allowed to draft or vote on any text or recommendationspertaining to their RWI?

Output: notpermitted

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are members allowed to draft or vote on any text or recommendationspertaining to their RWI?. ### Response: notpermitted.


Instruction: What is indicated in the list of writing committeemembers?

Output: Members who recused themselvesfrom voting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is indicated in the list of writing committeemembers?. ### Response: Members who recused themselvesfrom voting.


Instruction: What is disclosed in Appendix 1?

Output: RWI pertinent tothis guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is disclosed in Appendix 1?. ### Response: RWI pertinent tothis guideline.


Instruction: What is available as an online supplement to ensure complete transparency?

Output: comprehensive disclosureinformation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is available as an online supplement to ensure complete transparency?. ### Response: comprehensive disclosureinformation.


Instruction: Where is disclosure information for the Task Force available?

Output: http://www.cardiosource.org/en/ACC/About-ACC/Who-We-Are/Leadership/Guidelines-and-Documents-Task-Forces.aspx .

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is disclosure information for the Task Force available?. ### Response: http://www.cardiosource.org/en/ACC/About-ACC/Who-We-Are/Leadership/Guidelines-and-Documents-Task-Forces.aspx ..


Instruction: Who supports the work of writingcommittees without commercial support?

Output: ACCF andAHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who supports the work of writingcommittees without commercial support?. ### Response: ACCF andAHA.


Instruction: What did writing committeemembers volunteer for?

Output: this activity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did writing committeemembers volunteer for?. ### Response: this activity.


Instruction: What is the point of care forpracticing clinicians?

Output: relevance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the point of care forpracticing clinicians?. ### Response: relevance.


Instruction: What continues to oversee an ongoing process improvement initiative?

Output: the Task Force

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What continues to oversee an ongoing process improvement initiative?. ### Response: the Task Force.


Instruction: How many reports did the Institute of Medicine release in April 2011?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many reports did the Institute of Medicine release in April 2011?. ### Response: 2.


Instruction: What are the two reports that were released by the institute of medicine?

Output: Clinical Practice Guidelines We Can Trust andFinding WhatWorks in Health Care: Standards for Systematic Reviews(2,3).

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the two reports that were released by the institute of medicine?. ### Response: Clinical Practice Guidelines We Can Trust andFinding WhatWorks in Health Care: Standards for Systematic Reviews(2,3)..


Instruction: What are the ACCF/AHA practice guide-lines cited as being compliant with many of the proposed standards?

Output: Clinical Practice Guidelines We Can Trust andFinding WhatWorks in Health Care: Standards for Systematic Reviews

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the ACCF/AHA practice guide-lines cited as being compliant with many of the proposed standards?. ### Response: Clinical Practice Guidelines We Can Trust andFinding WhatWorks in Health Care: Standards for Systematic Reviews.


Instruction: What is under way for a thorough review of these reports and of ourcurrent methodology?

Output: further enhancements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is under way for a thorough review of these reports and of ourcurrent methodology?. ### Response: further enhancements.


Instruction: The recommendations in this guideline are considered current until they are what?

Output: superseded by a focused update

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The recommendations in this guideline are considered current until they are what?. ### Response: superseded by a focused update.


Instruction: What are recommendations in this guideline considered until they are superseded by a focused update or the full-text guideline is revised?

Output: current

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are recommendations in this guideline considered until they are superseded by a focused update or the full-text guideline is revised?. ### Response: current.


Instruction: Guidelines are official policy of which two organizations?

Output: ACCF and AHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Guidelines are official policy of which two organizations?. ### Response: ACCF and AHA.


Instruction: The reader is encouraged to consult what guideline(4)?

Output: full-text

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The reader is encouraged to consult what guideline(4)?. ### Response: full-text.


Instruction: What does the Executive Summary contain?

Output: only the recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Executive Summary contain?. ### Response: only the recommendations.


Instruction: Who is a member of the ACCF/AHA Task Force on Practice Guidelines?

Output: Jeffrey L. Anderson, MD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a member of the ACCF/AHA Task Force on Practice Guidelines?. ### Response: Jeffrey L. Anderson, MD.


Instruction: When was an extensive evidence review conducted?

Output: October 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was an extensive evidence review conducted?. ### Response: October 2011.


Instruction: When was the review conducted?

Output: October 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the review conducted?. ### Response: October 2011.


Instruction: When did the review include other references?

Output: April 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the review include other references?. ### Response: April 2013.


Instruction: Where are the relevant data included?

Output: Appendixes 1 and 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are the relevant data included?. ### Response: Appendixes 1 and 2.


Instruction: How many patients were treated with ceftaroline fosamil?

Output: 10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with ceftaroline fosamil?. ### Response: 10.


Instruction: What is the name of the retrospective case series of 10 patients?

Output: ceftaroline fosamil

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the retrospective case series of 10 patients?. ### Response: ceftaroline fosamil.


Instruction: What is the name of the drug used in large retrospective evaluation of the effectiveness and safety of ceftaroline fosamil therapy?

Output: Antimicrob Agents Chemother. 2014;58:2541–2546. doi: 10.1128/AAC.02371-13. 182

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used in large retrospective evaluation of the effectiveness and safety of ceftaroline fosamil therapy?. ### Response: Antimicrob Agents Chemother. 2014;58:2541–2546. doi: 10.1128/AAC.02371-13. 182.


Instruction: What are the names of the drugs used to treat bacterial infections?

Output: ceftaroline fosamil

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the drugs used to treat bacterial infections?. ### Response: ceftaroline fosamil.


Instruction: Who is the author of this study?

Output: Olaison L, Schadewitz K

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of this study?. ### Response: Olaison L, Schadewitz K.


Instruction: Fosamil therapy. Antimicrob Agents Chemother. 2014;58:2541–2546.

Output: 10.1128/AAC.02371-13. 182

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Fosamil therapy. Antimicrob Agents Chemother. 2014;58:2541–2546.. ### Response: 10.1128/AAC.02371-13. 182.


Instruction: What is the doi: 10.1128/AAC.02371-13?

Output: Antimicrob Agents Chemother.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the doi: 10.1128/AAC.02371-13?. ### Response: Antimicrob Agents Chemother..


Instruction: What is a contemporary update based on the International Collaboration on Endocarditis-Prospective Cohort Study Group?

Output: Coagulase-negative staphylococcal prosthetic valve endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a contemporary update based on the International Collaboration on Endocarditis-Prospective Cohort Study Group?. ### Response: Coagulase-negative staphylococcal prosthetic valve endocarditis.


Instruction: What is the name of the prospective cohort study?

Output: International Collaboration on Endocarditis-Prospective Cohort Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective cohort study?. ### Response: International Collaboration on Endocarditis-Prospective Cohort Study Group.


Instruction: What is the name of the bacterial infection caused by methi-cillin-resistant Staphylococcus?

Output: foreign body infection caused by meth-icillin-resistant Staphylococcus aureus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the bacterial infection caused by methi-cillin-resistant Staphylococcus?. ### Response: foreign body infection caused by meth-icillin-resistant Staphylococcus aureus.


Instruction: What is a possible outcome of combination versus single-agent treatment for staphylococcal endocarditis?

Output: Bacteriological

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a possible outcome of combination versus single-agent treatment for staphylococcal endocarditis?. ### Response: Bacteriological.


Instruction: When did J Antimicrob Chemother publish its 52:820-825?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J Antimicrob Chemother publish its 52:820-825?. ### Response: 2003.


Instruction: What was the cause of the experimental foreign body infection?

Output: meth-icillin-resistant Staphylococcus aureus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the cause of the experimental foreign body infection?. ### Response: meth-icillin-resistant Staphylococcus aureus.


Instruction: What is the name of the antimicrobial combination that was used to treat the foreign body infections?

Output: ceftaroline fosamil therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the antimicrobial combination that was used to treat the foreign body infections?. ### Response: ceftaroline fosamil therapy.


Instruction: When did the Antimicrob Agents Chemother publish?

Output: 1991

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Antimicrob Agents Chemother publish?. ### Response: 1991.


Instruction: What is Staphylococcus aureus prosthetic valve endocarditis: optimal manage-ment and risk factors for death?

Output: Coagulase-negative

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Staphylococcus aureus prosthetic valve endocarditis: optimal manage-ment and risk factors for death?. ### Response: Coagulase-negative.


Instruction: What is Wilson WR, Geraci JE. Antibiotic treatment of?

Output: infective endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Wilson WR, Geraci JE. Antibiotic treatment of?. ### Response: infective endocarditis.


Instruction: Annu Rev Med. 1983;34:413-427.

Output: 187

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Annu Rev Med. 1983;34:413-427.. ### Response: 187.


Instruction: What is the name of the microorganism that causes infective endocarditis?

Output: HACEK

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the microorganism that causes infective endocarditis?. ### Response: HACEK.


Instruction: When was the last issue of Annu Rev Med published?

Output: October 13, 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last issue of Annu Rev Med published?. ### Response: October 13, 2015.


Instruction: What was the title of the article published in 1983?

Output: Annu Rev Med.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the title of the article published in 1983?. ### Response: Annu Rev Med..


Instruction: Who was the author of this article?

Output: Wilson WR, Geraci JE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the author of this article?. ### Response: Wilson WR, Geraci JE.


Instruction: What is the name of the Swedish Society of Infectious Diseases Quality Assurance Study Group for Endocarditis?

Output: Olaison L, Schadewitz K

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Swedish Society of Infectious Diseases Quality Assurance Study Group for Endocarditis?. ### Response: Olaison L, Schadewitz K.


Instruction: In what year did enterococcal endocardiotis occur in Sweden?

Output: 1995-1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did enterococcal endocardiotis occur in Sweden?. ### Response: 1995-1999.


Instruction: What did Gavaldà J, Len O, Miró JM, Muoz P, Montejo M, Alarcón A, de la Largo J, Alarón A and de la largo A look at?

Output: Large retro-spective evaluation of the effectiveness and safety of ceftaroline fosamil therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Gavaldà J, Len O, Miró JM, Muoz P, Montejo M, Alarcón A, de la Largo J, Alarón A and de la largo A look at?. ### Response: Large retro-spective evaluation of the effectiveness and safety of ceftaroline fosamil therapy.


Instruction: What did the ences between the -blocker and placebo arms indicate?

Output: composite primary end point, death or cardiogenic shock alone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the ences between the -blocker and placebo arms indicate?. ### Response: composite primary end point, death or cardiogenic shock alone.


Instruction: What was the composite primary end point of the study?

Output: death or cardiogenic shock alone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the composite primary end point of the study?. ### Response: death or cardiogenic shock alone.


Instruction: Who should be used selectively and restricted to?

Output: patients with significant hypertension or tachycardia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should be used selectively and restricted to?. ### Response: patients with significant hypertension or tachycardia.


Instruction: What is tachycardia caused by?

Output: atrial arrhythmias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is tachycardia caused by?. ### Response: atrial arrhythmias.


Instruction: What are the current ACC/AHA guidelines for STEMI and UA/NSTEMI?

Output: recommend that oral β-blockade should be started within the first 24 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the current ACC/AHA guidelines for STEMI and UA/NSTEMI?. ### Response: recommend that oral β-blockade should be started within the first 24 hours.


Instruction: When should oral -blockade be started?

Output: within the first 24 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When should oral -blockade be started?. ### Response: within the first 24 hours.


Instruction: What should be started within the first 24 hours?

Output: oral β-blockade

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be started within the first 24 hours?. ### Response: oral β-blockade.


Instruction: What is the choice of a -blocker based on?

Output: pharmacokinetic and side-effect criteria and phy-sician familiarity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the choice of a -blocker based on?. ### Response: pharmacokinetic and side-effect criteria and phy-sician familiarity.


Instruction: Short-acting cardioselective  blockers without intrinsic sympathomimetic activity are what?

Output: preferable

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Short-acting cardioselective  blockers without intrinsic sympathomimetic activity are what?. ### Response: preferable.


Instruction: What are cardioselective -blockers without intrinsic sympathomimetic activity?

Output: metoprolol or bisoprolol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are cardioselective -blockers without intrinsic sympathomimetic activity?. ### Response: metoprolol or bisoprolol.


Instruction: What blockers block 2 and 1 adrenergic receptors?

Output: Carvedilol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What blockers block 2 and 1 adrenergic receptors?. ### Response: Carvedilol.


Instruction: Carvedilol has more potent BP-lowering effects than what?

Output: β1-selective agents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Carvedilol has more potent BP-lowering effects than what?. ### Response: β1-selective agents.


Instruction: What is a contraindication to the use of -blockers in ACS?

Output: marked first-degree heart block

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a contraindication to the use of -blockers in ACS?. ### Response: marked first-degree heart block.


Instruction: What is the ECG PR interval >0.24 second?

Output: first-degree heart block

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ECG PR interval >0.24 second?. ### Response: first-degree heart block.


Instruction: What is PR interval >0.24 second?

Output: first-degree heart block

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PR interval >0.24 second?. ### Response: first-degree heart block.