Instruction: What year did the Engl J Med publish 372:2387–97.4.4?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did the Engl J Med publish 372:2387–97.4.4?. ### Response: 2015.


Instruction: What is the primary prevention S4.4-1?

Output: Ezetimibe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary prevention S4.4-1?. ### Response: Ezetimibe.


Instruction: How long does the association of coronary artery calcium with atherosclerotic cardiovascular disease events last?

Output: Ten-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does the association of coronary artery calcium with atherosclerotic cardiovascular disease events last?. ### Response: Ten-year.


Instruction: Who is responsible for the psychology of clinical decision making?

Output: Avorn J

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is responsible for the psychology of clinical decision making?. ### Response: Avorn J.


Instruction: What is the psychology of clinical decision making—implications for medication use?

Output: Avorn J

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the psychology of clinical decision making—implications for medication use?. ### Response: Avorn J.


Instruction: What did the 2016 ACC expert consensus decision pathway on the role of non-statin therapies for?

Output: LDL-cholesterol lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the 2016 ACC expert consensus decision pathway on the role of non-statin therapies for?. ### Response: LDL-cholesterol lowering.


Instruction: What did the American College of Cardiology Task Force on Clinical Expert Consensus Documents do?

Output: the role of non-statin therapies for LDL-cholesterol lowering in the management of atherosclerotic cardiovascular disease risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the American College of Cardiology Task Force on Clinical Expert Consensus Documents do?. ### Response: the role of non-statin therapies for LDL-cholesterol lowering in the management of atherosclerotic cardiovascular disease risk.


Instruction: What was the focus of the 2017 focused update of the 2016 ACC expert consensus decision pathway?

Output: role of non-statin therapies for LDL-cholesterol lowering in the man-agement of atherosclerotic cardiovascular disease risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the focus of the 2017 focused update of the 2016 ACC expert consensus decision pathway?. ### Response: role of non-statin therapies for LDL-cholesterol lowering in the man-agement of atherosclerotic cardiovascular disease risk.


Instruction: What was the 2016 ACC expert consensus decision pathway on?

Output: the role of non-statin therapies for LDL-cholesterol lowering in the management of atherosclerotic cardiovascular disease risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 2016 ACC expert consensus decision pathway on?. ### Response: the role of non-statin therapies for LDL-cholesterol lowering in the management of atherosclerotic cardiovascular disease risk.


Instruction: What is the role of non-statin therapies for LDL-cholesterol lowering in the man-agement of atherosclerotic cardiovascular disease risk?

Output: management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of non-statin therapies for LDL-cholesterol lowering in the man-agement of atherosclerotic cardiovascular disease risk?. ### Response: management.


Instruction: What is the 2017 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk?

Output: 2016 ACC expert consensus decision pathway

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2017 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk?. ### Response: 2016 ACC expert consensus decision pathway.


Instruction: What did the American College of Cardiology/American Heart Association Task Force on Practice Guidelines do?

Output: reduce cardiovascular risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the American College of Cardiology/American Heart Association Task Force on Practice Guidelines do?. ### Response: reduce cardiovascular risk.


Instruction: What was the 2013 AHA/ACC/TOS guideline for the management of?

Output: overweight and obesity in adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 2013 AHA/ACC/TOS guideline for the management of?. ### Response: overweight and obesity in adults.


Instruction: What was a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society?

Output: AHA/ACC/TOS guideline for the management of overweight and obesity in adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society?. ### Response: AHA/ACC/TOS guideline for the management of overweight and obesity in adults.


Instruction: What was the name of the report?

Output: Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the report?. ### Response: Heart Association Task Force on Practice Guidelines.


Instruction: When was the Circulation. 2014;129:S102-38?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circulation. 2014;129:S102-38?. ### Response: 2014.


Instruction: Where can you find the 2008 Physical Activity Guidelines for Americans?

Output: US Department of Health and Human Services

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find the 2008 Physical Activity Guidelines for Americans?. ### Response: US Department of Health and Human Services.


Instruction: What is the primary prevention of cardiovascular disease with a Mediterranean diet?

Output: S4.4-9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary prevention of cardiovascular disease with a Mediterranean diet?. ### Response: S4.4-9.


Instruction: When was the N Engl J Med 2013 368:1279-90 published?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the N Engl J Med 2013 368:1279-90 published?. ### Response: 2013.


Instruction: What was the name of the 8th ed. 2015-2020 Dietary Guidelines for Americans?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the 8th ed. 2015-2020 Dietary Guidelines for Americans?. ### Response: 2015.


Instruction: What are the 2015 dietary guidelines available at?

Output: http://health.gov/dietary  guidelines/2015/guidelines/.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the 2015 dietary guidelines available at?. ### Response: http://health.gov/dietary  guidelines/2015/guidelines/..


Instruction: What is the name of the document available at http://health.gov/dietary guidelines/2015/guidelines?

Output: Dietary Guidelines for Americans

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the document available at http://health.gov/dietary guidelines/2015/guidelines?. ### Response: Dietary Guidelines for Americans.


Instruction: What was the focus of the 2015 ACC/AHA/SCAI Focused Update on Primary Percutaneous Coronary Intervention for Patients With ST-Elevation Myocardial Infarction?

Output: Author Relationships With Industry and Other Entities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the focus of the 2015 ACC/AHA/SCAI Focused Update on Primary Percutaneous Coronary Intervention for Patients With ST-Elevation Myocardial Infarction?. ### Response: Author Relationships With Industry and Other Entities.


Instruction: When was the ST-elevation MMI Writing Committee created?

Output: February 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the ST-elevation MMI Writing Committee created?. ### Response: February 2014.


Instruction: Who is the Chair of Harvard Medical School?

Output: Patrick T. O’Gara

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Chair of Harvard Medical School?. ### Response: Patrick T. O’Gara.


Instruction: Who is the Vice Chair of Tulane University School ofMedicine?

Output: Frederick G. Kushner

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Vice Chair of Tulane University School ofMedicine?. ### Response: Frederick G. Kushner.


Instruction: What is the name of the medical director of Heart Clinic ofLouisiana?

Output: Frederick G. Kushner

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the medical director of Heart Clinic ofLouisiana?. ### Response: Frederick G. Kushner.


Instruction: Who is an Associate Professor of Medicine at Mount Sinai?

Output: Deborah D. Ascheim

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is an Associate Professor of Medicine at Mount Sinai?. ### Response: Deborah D. Ascheim.


Instruction: Who is the founder of the Cleveland ClinicFoundation?

Output: Mina K. Chung

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the founder of the Cleveland ClinicFoundation?. ### Response: Mina K. Chung.


Instruction: What is the name of the professor of medicine at UCSF Philip R. Lee Institute for Health PolicyStudies?

Output: Ralph G. Brindis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor of medicine at UCSF Philip R. Lee Institute for Health PolicyStudies?. ### Response: Ralph G. Brindis.


Instruction: Who is a Professor ofMedicine at UT Southwestern MedicalCenter?

Output: James A. de Lemos

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a Professor ofMedicine at UT Southwestern MedicalCenter?. ### Response: James A. de Lemos.


Instruction: What is the Department of Emergency Medicine's Professor and ChairNone?

Output: Distinguished Chair inClinical Care andResearch

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Department of Emergency Medicine's Professor and ChairNone?. ### Response: Distinguished Chair inClinical Care andResearch.


Instruction: Who is the Chair inclinical care and research?

Output: Deborah B. Diercks UT Southwestern MedicalCenter—Audre andBernard Rapoport

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Chair inclinical care and research?. ### Response: Deborah B. Diercks UT Southwestern MedicalCenter—Audre andBernard Rapoport.


Instruction: What is the Department of Emergency Medicine called?

Output: —Professor and Chair

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Department of Emergency Medicine called?. ### Response: —Professor and Chair.


Instruction: Who published this article on behalf of the Society for CardiovascularAngiography and Interventions?

Output: Levine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published this article on behalf of the Society for CardiovascularAngiography and Interventions?. ### Response: Levine.


Instruction: When was this article published?

Output: 1522726x

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this article published?. ### Response: 1522726x.


Instruction: On what date was Wiley Online Library launched?

Output: 03/05/2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On what date was Wiley Online Library launched?. ### Response: 03/05/2023.


Instruction: What is the name of the document that governs the use of OA articles?

Output: Creative Commons License

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the document that governs the use of OA articles?. ### Response: Creative Commons License.


Instruction: How is OA governed by the Creative Commons License?

Output: Terms and Conditions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is OA governed by the Creative Commons License?. ### Response: Terms and Conditions.


Instruction: What is a microbiological diagnosis of infective endocarditis?

Output: unusual or fastidious microorganisms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a microbiological diagnosis of infective endocarditis?. ### Response: unusual or fastidious microorganisms.


Instruction: What is the name of the journal that studies the bacteremia of the bacterial endotic?

Output: JAMA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies the bacteremia of the bacterial endotic?. ### Response: JAMA.


Instruction: Where is Medicine (Baltimore)?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Medicine (Baltimore)?. ### Response: 2003.


Instruction: What is the name of the clinical study of culture-negative endocarditis?

Output: Clin Infect Dis.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the clinical study of culture-negative endocarditis?. ### Response: Clin Infect Dis..


Instruction: How many cases were there from a one-year nationwide survey in France?

Output: 88

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many cases were there from a one-year nationwide survey in France?. ### Response: 88.


Instruction: How long was the survey conducted in France?

Output: one-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the survey conducted in France?. ### Response: one-year.


Instruction: What was the result of the survey?

Output: analysis of 88 cases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the result of the survey?. ### Response: analysis of 88 cases.


Instruction: How long did the survey last?

Output: one-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the survey last?. ### Response: one-year.


Instruction: What is suppression by outpatient antibiotic therapy in patients with bacterial endocarditis?

Output: Blood culture positivity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is suppression by outpatient antibiotic therapy in patients with bacterial endocarditis?. ### Response: Blood culture positivity.


Instruction: What was the name of the 1982 issue of Arch Intern Med?

Output: 142:263–268

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the 1982 issue of Arch Intern Med?. ### Response: 142:263–268.


Instruction: How many blood cultures were negative in 1992?

Output: 1215–1217

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many blood cultures were negative in 1992?. ### Response: 1215–1217.


Instruction: What is a guide to utilization of the microbiology labo-ratory for diagnosis of infectious diseases?

Output: 2013 recommendations by the Infectious Diseases Society of America (IDSA) and the American Society for Microbiology (ASM)(a).

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a guide to utilization of the microbiology labo-ratory for diagnosis of infectious diseases?. ### Response: 2013 recommendations by the Infectious Diseases Society of America (IDSA) and the American Society for Microbiology (ASM)(a)..


Instruction: What is the acronym for the Infectious Diseases Society of America?

Output: IDSA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the Infectious Diseases Society of America?. ### Response: IDSA.


Instruction: What are the acronyms for the American Society for Microbiology?

Output: ASM)(a

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the acronyms for the American Society for Microbiology?. ### Response: ASM)(a.


Instruction: When was the Clin Infect Dis published?

Output: 1995

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Clin Infect Dis published?. ### Response: 1995.


Instruction: What is the name of the bacteria that causes human infections?

Output: Bartonella

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the bacteria that causes human infections?. ### Response: Bartonella.


Instruction: When was Antimicrob Agents Chemother published?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Antimicrob Agents Chemother published?. ### Response: 2004.


Instruction: What is a high prevalence of fungi?

Output: blood culture-negative early prosthetic valve endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a high prevalence of fungi?. ### Response: blood culture-negative early prosthetic valve endocarditis.


Instruction: What does prosthetic valve endocarditis reveal?

Output: high prevalence of fungi

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does prosthetic valve endocarditis reveal?. ### Response: high prevalence of fungi.


Instruction: What is the prevalence of fungi?

Output: high

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the prevalence of fungi?. ### Response: high.


Instruction: When did Heart. 2010;96:743-747.

Output: Investigation of blood culture-negative early prosthetic valve endocarditis reveals high prevalence of fungi

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Heart. 2010;96:743-747.. ### Response: Investigation of blood culture-negative early prosthetic valve endocarditis reveals high prevalence of fungi.


Instruction: What was the doi: 10.1136/hrt.2009.181594?

Output: Heart. 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the doi: 10.1136/hrt.2009.181594?. ### Response: Heart. 2010.


Instruction: How many new cases of blood culture-negative endocarditis were included in the study?

Output: 819

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many new cases of blood culture-negative endocarditis were included in the study?. ### Response: 819.


Instruction: What is the name of the prospective study of 819 new cases?

Output: negative endocardi-tis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective study of 819 new cases?. ### Response: negative endocardi-tis.


Instruction: When did Clin Infect Dis issue 51:131–140?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Clin Infect Dis issue 51:131–140?. ### Response: 2010.


Instruction: What type of endocarditis does Tropheryma whipplei cause?

Output: culture-negative

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of endocarditis does Tropheryma whipplei cause?. ### Response: culture-negative.


Instruction: What is the name of the heart valve involve-ment in the antiphospholipid syndrome?

Output: Libman-Sacks endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the heart valve involve-ment in the antiphospholipid syndrome?. ### Response: Libman-Sacks endocarditis.


Instruction: When did Circulation. 1996;93:1579-1587?

Output: 1996

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circulation. 1996;93:1579-1587?. ### Response: 1996.


Instruction: What does the Blood Institute recommend to lower BP at?

Output: SBP of ≥ 140 mm Hg or DBP of ≥ 90 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Blood Institute recommend to lower BP at?. ### Response: SBP of ≥ 140 mm Hg or DBP of ≥ 90 mm Hg.


Instruction: What is the blood institute's goal SBP of 140 mm Hg?

Output: <140 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the blood institute's goal SBP of 140 mm Hg?. ### Response: <140 mm Hg.


Instruction: What is the goal DBP?

Output: <90 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the goal DBP?. ### Response: <90 mm Hg.


Instruction: When did the International Society on Hypertension in Blacks revise its recommendations for managing BP in this at-risk population?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the International Society on Hypertension in Blacks revise its recommendations for managing BP in this at-risk population?. ### Response: 2010.


Instruction: In the absence of target-organ damage, what should the target be?

Output: <135/85 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the absence of target-organ damage, what should the target be?. ### Response: <135/85 mm Hg.


Instruction: What should the target be in the presence of tar -get-organ damage?

Output: <130/80 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should the target be in the presence of tar -get-organ damage?. ### Response: <130/80 mm Hg.


Instruction: What is preferred for patients within 10 mm Hg above target?

Output: monotherapy with diuretic or calcium channel blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is preferred for patients within 10 mm Hg above target?. ### Response: monotherapy with diuretic or calcium channel blocker.


Instruction: How is 2-drug therapy pre-ferred?

Output: either with a calcium channel blocker plus renin-angio-tensin system blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is 2-drug therapy pre-ferred?. ### Response: either with a calcium channel blocker plus renin-angio-tensin system blocker.


Instruction: What is pre-ferred with a calcium channel blocker plus renin-angio-tensin system blocker?

Output: 2-drug therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is pre-ferred with a calcium channel blocker plus renin-angio-tensin system blocker?. ### Response: 2-drug therapy.


Instruction: What is used in edematous or volume-overloaded states?

Output: thiazide diuretic plus a renin-angiotensin system blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used in edematous or volume-overloaded states?. ### Response: thiazide diuretic plus a renin-angiotensin system blocker.


Instruction: Where is the National Heart, Lung and Blood Institute located?

Output: black

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the National Heart, Lung and Blood Institute located?. ### Response: black.


Instruction: What did the National Heart, Lung and Blood Institute panel originally address?

Output: hypertension management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the National Heart, Lung and Blood Institute panel originally address?. ### Response: hypertension management.


Instruction: What should initial antihypertensive therapy include in the general black population?

Output: a thiazide-type diuretic or a calcium channel blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should initial antihypertensive therapy include in the general black population?. ### Response: a thiazide-type diuretic or a calcium channel blocker.


Instruction: When was the ALLHAT trial downloaded?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the ALLHAT trial downloaded?. ### Response: April 28, 2023.


Instruction: What year did the American Medical Association publish its 2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did the American Medical Association publish its 2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults?. ### Response: 2013.


Instruction: What is the gold standard for determining efficacy and effectiveness?

Output: randomizedcontrolledtrials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the gold standard for determining efficacy and effectiveness?. ### Response: randomizedcontrolledtrials.


Instruction: What type of therapy is recommended in patients with AF and carotid stenosis treated with revascularization?

Output: OAC therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is recommended in patients with AF and carotid stenosis treated with revascularization?. ### Response: OAC therapy.


Instruction: What is short-term concomitant antiplatelet therapy generally used in the immediate aftermath?

Output: revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is short-term concomitant antiplatelet therapy generally used in the immediate aftermath?. ### Response: revascularization.


Instruction: What type of therapy is used in the immediate post-revascularization period?

Output: Short-term concomitant antiplatelet therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is used in the immediate post-revascularization period?. ### Response: Short-term concomitant antiplatelet therapy.


Instruction: What are ischemic strokes termed in North America and Europe?

Output: cryptogenic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are ischemic strokes termed in North America and Europe?. ### Response: cryptogenic.


Instruction: How many strokes remain of uncertain etiology?

Output: 4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes remain of uncertain etiology?. ### Response: 4.


Instruction: Atherosclerosis is also known as what?

Output: large artery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atherosclerosis is also known as what?. ### Response: large artery.


Instruction: What is the term for small arterydisease?

Output: large artery atherosclerosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for small arterydisease?. ### Response: large artery atherosclerosis.


Instruction: Why are most cryptogenic strokes embolic?

Output: a morerecent concept of ESUS has been developed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why are most cryptogenic strokes embolic?. ### Response: a morerecent concept of ESUS has been developed.


Instruction: ESUS has been defined as what type of stroke?

Output: cryptogenic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ESUS has been defined as what type of stroke?. ### Response: cryptogenic.


Instruction: How long is adequate diagnosticpathway?

Output: at least 24 h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is adequate diagnosticpathway?. ### Response: at least 24 h.


Instruction: What is not lacunar?

Output: subcortical, <15 mm diameter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not lacunar?. ### Response: subcortical, <15 mm diameter.


Instruction: How much does absence of extracranial or intracranial atherosclerosis cause?

Output: $50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much does absence of extracranial or intracranial atherosclerosis cause?. ### Response: $50%.


Instruction: What type of stenosis is present in the arteries supplying the area ofischemia?

Output: luminal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of stenosis is present in the arteries supplying the area ofischemia?. ### Response: luminal.


Instruction: What is not a major-risk cardioembolic source ofembolism?

Output: permanent or paroxysmal AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not a major-risk cardioembolic source ofembolism?. ### Response: permanent or paroxysmal AF.


Instruction: What is another name for infectiveendocarditis?

Output: valvular vegetations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for infectiveendocarditis?. ### Response: valvular vegetations.


Instruction: What is ESUS a subcategory of?

Output: cryptogenic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ESUS a subcategory of?. ### Response: cryptogenic stroke.


Instruction: How many ischemic strokes are caused by cryptogenic stroke?

Output: 1 in 6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many ischemic strokes are caused by cryptogenic stroke?. ### Response: 1 in 6.


Instruction: What might be important differences between underlying embolicsources if detected?

Output: aortic arch atheroma, patentforamen ovale, and paroxysmal AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What might be important differences between underlying embolicsources if detected?. ### Response: aortic arch atheroma, patentforamen ovale, and paroxysmal AF.


Instruction: What does this brief section only refer to?

Output: paroxysmal AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does this brief section only refer to?. ### Response: paroxysmal AF.


Instruction: How many patients with ischemic stroke will be identified by routine Holter or event looprecorder monitoring?

Output: approximately 1 in 20

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with ischemic stroke will be identified by routine Holter or event looprecorder monitoring?. ### Response: approximately 1 in 20.


Instruction: How many RCTs clearly showed that prolonged cardiacmonitoring increases the detection of occult AF inpatients?

Output: Two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs clearly showed that prolonged cardiacmonitoring increases the detection of occult AF inpatients?. ### Response: Two.


Instruction: What increases the detection of occult AF inpatients with TIA or acute ischemic stroke?

Output: prolonged cardiacmonitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What increases the detection of occult AF inpatients with TIA or acute ischemic stroke?. ### Response: prolonged cardiacmonitoring.


Instruction: How many patients were randomly assigned to prolonged ambulatory cardiacmonitoring with a subcutaneous implantable looprecorder or to a control group with conventional follow-up?

Output: 441

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were randomly assigned to prolonged ambulatory cardiacmonitoring with a subcutaneous implantable looprecorder or to a control group with conventional follow-up?. ### Response: 441.


Instruction: What did the control group with conventional follow-up detect more of?

Output: AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the control group with conventional follow-up detect more of?. ### Response: AF.


Instruction: What group had more AF in the monitored group?

Output: Cryptogenic Stroke and UnderlyingAtrial Fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What group had more AF in the monitored group?. ### Response: Cryptogenic Stroke and UnderlyingAtrial Fibrillation.


Instruction: Infective Endocarditis in Childhood: 2015 Update 14973.

Output: Baltimore et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Infective Endocarditis in Childhood: 2015 Update 14973.. ### Response: Baltimore et al.


Instruction: Synergy studies with a -lactam agent and an aminoglycoside may be reasonable in what?

Output: determining optimal therapy of enterococcal or penicillin-nonsusceptible streptococcal IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Synergy studies with a -lactam agent and an aminoglycoside may be reasonable in what?. ### Response: determining optimal therapy of enterococcal or penicillin-nonsusceptible streptococcal IE.


Instruction: What is IE (Class IIb; Level of Evidence C)?

Output: enterococcal or penicillin-nonsusceptible streptococcal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is IE (Class IIb; Level of Evidence C)?. ### Response: enterococcal or penicillin-nonsusceptible streptococcal.


Instruction: What may sup-port the diagnosis of IE in children?

Output: nonspecific laboratory findings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may sup-port the diagnosis of IE in children?. ### Response: nonspecific laboratory findings.


Instruction: What may be caused by a prosthetic valve in the absence of IE?

Output: Chronic low-grade hemolysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be caused by a prosthetic valve in the absence of IE?. ### Response: Chronic low-grade hemolysis.


Instruction: What is not consistent with IE, but immature forms may be present on peripheral blood smears?

Output: Leukocytosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not consistent with IE, but immature forms may be present on peripheral blood smears?. ### Response: Leukocytosis.


Instruction: Acute IE is likely to mani-fest what?

Output: leukocytosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Acute IE is likely to mani-fest what?. ### Response: leukocytosis.


Instruction: Thrombocytopenia can occur, especially in neonates with what type of disease?

Output: IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Thrombocytopenia can occur, especially in neonates with what type of disease?. ### Response: IE.


Instruction: What can occur in neonates with IE?

Output: Thrombocytopenia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can occur in neonates with IE?. ### Response: Thrombocytopenia.


Instruction: Hypergammaglobulinemia and elevated acute-phase reactants are present in a large proportion of patients?

Output: ease. Chronic low-grade hemolysis also may be caused by a prosthetic valve in the absence of IE. Leukocytosis is not a consistent feature of IE, but immature forms may be pres-ent on peripheral blood smears. Acute IE is likely to mani-fest leukocytosis. Thrombocytopenia can occur, particularly in neonates with IE. Hypergammaglobulinemia and elevated acute-phase reactants (eg, erythrocyte sedimentation rate and C-reactive protein

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hypergammaglobulinemia and elevated acute-phase reactants are present in a large proportion of patients?. ### Response: ease. Chronic low-grade hemolysis also may be caused by a prosthetic valve in the absence of IE. Leukocytosis is not a consistent feature of IE, but immature forms may be pres-ent on peripheral blood smears. Acute IE is likely to mani-fest leukocytosis. Thrombocytopenia can occur, particularly in neonates with IE. Hypergammaglobulinemia and elevated acute-phase reactants (eg, erythrocyte sedimentation rate and C-reactive protein.


Instruction: Hematuria may occur and be accompanied by what?

Output: red blood cell casts, proteinuria, and renal insufficiency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hematuria may occur and be accompanied by what?. ### Response: red blood cell casts, proteinuria, and renal insufficiency.


Instruction: Proteinuria and renal insufficiency are common in what type of IE patients?

Output: patients who develop immune complex glomerulonephritis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Proteinuria and renal insufficiency are common in what type of IE patients?. ### Response: patients who develop immune complex glomerulonephritis.


Instruction: What is less common in children than adults?

Output: Hematuria may occur and be accompanied by red blood cell casts, proteinuria, and renal insufficiency in patients who develop immune complex glomerulonephritis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is less common in children than adults?. ### Response: Hematuria may occur and be accompanied by red blood cell casts, proteinuria, and renal insufficiency in patients who develop immune complex glomerulonephritis.


Instruction: In patients with immune complexes, hypocomple-mentemia may occur.

Output: Thrombocytopenia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with immune complexes, hypocomple-mentemia may occur.. ### Response: Thrombocytopenia.


Instruction: Rheumatoid factor is present in a substantial pro-portion of what?

Output: IE patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Rheumatoid factor is present in a substantial pro-portion of what?. ### Response: IE patients.


Instruction: How long is the duration of a patient's illness?

Output: >6 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the duration of a patient's illness?. ### Response: >6 weeks.


Instruction: What is an example of ventricular ectopy?

Output: rhythm disorders

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of ventricular ectopy?. ### Response: rhythm disorders.


Instruction: What may signal a serious or life-threatening complication?

Output: heart block

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may signal a serious or life-threatening complication?. ### Response: heart block.


Instruction: What is the standard diagnostic method for identifying the intracar -diac manifestations of IE?

Output: 2-dimensional echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the standard diagnostic method for identifying the intracar -diac manifestations of IE?. ### Response: 2-dimensional echocardiography.


Instruction: What does TTE stand for?

Output: transthoracic echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does TTE stand for?. ### Response: transthoracic echocardiography.


Instruction: What is TTE usually sufficient for for children to fully understand?

Output: cardiovascular findings in definite or presumptive IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is TTE usually sufficient for for children to fully understand?. ### Response: cardiovascular findings in definite or presumptive IE.


Instruction: TTE is superior to what in diagnosing paravalvular leakage?

Output: transesophageal echocardiog-raphy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: TTE is superior to what in diagnosing paravalvular leakage?. ### Response: transesophageal echocardiog-raphy.


Instruction: What is reasonable to consider for infants and children in whom TTE views may be limited?

Output: TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable to consider for infants and children in whom TTE views may be limited?. ### Response: TEE.


Instruction: What are left ventricular outflow tract compli-cations?

Output: root abscesses; involvement of the sinuses of Valsalva; and prosthetic valve endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are left ventricular outflow tract compli-cations?. ### Response: root abscesses; involvement of the sinuses of Valsalva; and prosthetic valve endocarditis.


Instruction: Who has had chest wall disruptions from previous surgery or from trauma?

Output: infants and children

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who has had chest wall disruptions from previous surgery or from trauma?. ### Response: infants and children.


Instruction: What is not well developed in pediatric patients?

Output: information

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not well developed in pediatric patients?. ### Response: information.


Instruction: Data from series in adult patients suggest what?

Output: intracardiac echocardiography (ICE) may also be useful

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Data from series in adult patients suggest what?. ### Response: intracardiac echocardiography (ICE) may also be useful.


Instruction: What does ICE stand for?

Output: intracardiac echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ICE stand for?. ### Response: intracardiac echocardiography.


Instruction: What is ICE?

Output: intracardiac echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ICE?. ### Response: intracardiac echocardiography.


Instruction: How can ICE be useful?

Output: data from series in adult patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can ICE be useful?. ### Response: data from series in adult patients.


Instruction: What have several observational studies reported for risk reduction in long QT syndrome?

Output: effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have several observational studies reported for risk reduction in long QT syndrome?. ### Response: effectiveness.


Instruction: What appears less effective?

Output: meto-prolol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What appears less effective?. ### Response: meto-prolol.


Instruction: RCTs to assess comparative efficacy of specific beta blockers are unavailable?

Output: S7.9.1.1-41

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: RCTs to assess comparative efficacy of specific beta blockers are unavailable?. ### Response: S7.9.1.1-41.


Instruction: Who favors the use of nadolol?

Output: many centers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who favors the use of nadolol?. ### Response: many centers.


Instruction: What did one study report reduced risk of for VA?

Output: atenolol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did one study report reduced risk of for VA?. ### Response: atenolol.


Instruction: Who was not associated with risk reduction for long QT syndrome type 2?

Output: nado-lol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was not associated with risk reduction for long QT syndrome type 2?. ### Response: nado-lol.


Instruction: What should patients receiving a beta blocker undergo to assess changes in over time?

Output: ongoing monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients receiving a beta blocker undergo to assess changes in over time?. ### Response: ongoing monitoring.


Instruction: What should a patient undergo with exertion to assess adequacy of beta blockade with?

Output: ongoing monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should a patient undergo with exertion to assess adequacy of beta blockade with?. ### Response: ongoing monitoring.


Instruction: High-risk patients with long QT syndrome include those with QTc >500 ms, genotypes what?

Output: long QT syndrome type 2 and long QT syn-drome type 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: High-risk patients with long QT syndrome include those with QTc >500 ms, genotypes what?. ### Response: long QT syndrome type 2 and long QT syn-drome type 3.


Instruction: How old are females with genotype long QT syndrome type 2?

Output: <40 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old are females with genotype long QT syndrome type 2?. ### Response: <40 years of age.


Instruction: What is the onset of symptoms at 10 years of age?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the onset of symptoms at 10 years of age?. ### Response: <.


Instruction: Who are at a higher risk of recurrent syncope or cardiac arrest?

Output: patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who are at a higher risk of recurrent syncope or cardiac arrest?. ### Response: patients.


Instruction: What are patients with long QT syndrome type 2 at a higher risk of?

Output: postpartum cardiac arrest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients with long QT syndrome type 2 at a higher risk of?. ### Response: postpartum cardiac arrest.


Instruction: Who should receive prepreg-nancy counseling?

Output: Women with long QT syndrome type 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should receive prepreg-nancy counseling?. ### Response: Women with long QT syndrome type 2.


Instruction: What is the risk of SCA or appropriate ICD shocks?

Output: increased risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of SCA or appropriate ICD shocks?. ### Response: increased risk.


Instruction: What is warranted to prevent SCD?

Output: escalation of therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is warranted to prevent SCD?. ### Response: escalation of therapy.


Instruction: What earlier stud-ies reported benefit of antibradycardia pacing, Table 10?

Output: prevent SCD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What earlier stud-ies reported benefit of antibradycardia pacing, Table 10?. ### Response: prevent SCD.


Instruction: Antiarrhythmic MedicationsPsychotropics Antibiotics OtherWhat antidepressants Ciprofloxacin Ondansetron

Output: Dronedarone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Antiarrhythmic MedicationsPsychotropics Antibiotics OtherWhat antidepressants Ciprofloxacin Ondansetron. ### Response: Dronedarone.


Instruction: What does Amiodarone rarely cause?

Output: torsades de pointes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Amiodarone rarely cause?. ### Response: torsades de pointes.


Instruction: What is the most complete list of antidepressants maintained at?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most complete list of antidepressants maintained at?. ### Response: www.crediblemeds.org.


Instruction: What is intended to diagnose severe hypertriglyceridemia and/or hypercholesterolemia?

Output: Initial evaluation of the lipid profile

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is intended to diagnose severe hypertriglyceridemia and/or hypercholesterolemia?. ### Response: Initial evaluation of the lipid profile.


Instruction: What medical conditions cause secondarydyslipidemias?

Output: hypothyroidism, excessive alcoholconsumption, nephrotic syndrome, diabetes mellitus, andliver disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What medical conditions cause secondarydyslipidemias?. ### Response: hypothyroidism, excessive alcoholconsumption, nephrotic syndrome, diabetes mellitus, andliver disease.


Instruction: Corticosteroids, diuretics, and 13-cis-retinoic acid are medications that may lead to what?

Output: dyslipidemias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Corticosteroids, diuretics, and 13-cis-retinoic acid are medications that may lead to what?. ### Response: dyslipidemias.


Instruction: What are diuretics called?

Output: corticosteroids, diuretics, 13- cis-retinoic acid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are diuretics called?. ### Response: corticosteroids, diuretics, 13- cis-retinoic acid.


Instruction: What is the name of the book written by C Wanner?

Output: Synopsis of clinical practice guideline on lipid management in CKD1304 Kidney International

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the book written by C Wanner?. ### Response: Synopsis of clinical practice guideline on lipid management in CKD1304 Kidney International.


Instruction: What is routinely used for de novo lesions or in-stent resteno-sis?

Output: Rotational atherectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is routinely used for de novo lesions or in-stent resteno-sis?. ### Response: Rotational atherectomy.


Instruction: What was associated with higherrates of MACE at 30 days and no reduction in restenosis? What is a limited role in facilitating the dilation or stenting oflesions that cannot be crossed or expanded with PCI?

Output: Rotational atherectomy in RCTs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with higherrates of MACE at 30 days and no reduction in restenosis? What is a limited role in facilitating the dilation or stenting oflesions that cannot be crossed or expanded with PCI?. ### Response: Rotational atherectomy in RCTs.


Instruction: What can't be crossed or expanded with PCI?

Output: lesions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can't be crossed or expanded with PCI?. ### Response: lesions.


Instruction: What are no longer marketed in the United States?

Output: Devices for directional coronary atherectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are no longer marketed in the United States?. ### Response: Devices for directional coronary atherectomy.


Instruction: How is aspiration thrombectomy reasonable?

Output: patientsundergoing primary PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is aspiration thrombectomy reasonable?. ### Response: patientsundergoing primary PCI.


Instruction: What appears to be dependent on the type of thrombectomy techniqueused?

Output: The benefit of thrombectomy in patients with STEMI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What appears to be dependent on the type of thrombectomy techniqueused?. ### Response: The benefit of thrombectomy in patients with STEMI.


Instruction: What has no clinical benefit been demonstrated inprimary PCI?

Output: routine rheolytic throm-bectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has no clinical benefit been demonstrated inprimary PCI?. ### Response: routine rheolytic throm-bectomy.


Instruction: Two RCTs522,523 and a meta-analysis524support the use of what?

Output: manual aspiration thrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Two RCTs522,523 and a meta-analysis524support the use of what?. ### Response: manual aspiration thrombectomy.


Instruction: What is used to improve microvascular reperfusion and de-crease MACE?

Output: manual aspiration thrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used to improve microvascular reperfusion and de-crease MACE?. ### Response: manual aspiration thrombectomy.


Instruction: What might be considered for fibrotic ormoderately calcified lesions that cannot be laser angioplasty?

Output: conventional balloon angioplasty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What might be considered for fibrotic ormoderately calcified lesions that cannot be laser angioplasty?. ### Response: conventional balloon angioplasty.


Instruction: What type of lesions can't be crossed or dilated with conventional balloon angioplasty?

Output: fibrotic ormoderately calcified lesions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of lesions can't be crossed or dilated with conventional balloon angioplasty?. ### Response: fibrotic ormoderately calcified lesions.


Instruction: What should not be used routinely dur-ing PCI?

Output: Cutting balloon angioplasty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not be used routinely dur-ing PCI?. ### Response: Cutting balloon angioplasty.


Instruction: What may laser angioplasty be of use in thetreatment of lesions that are difficult to dilate?

Output: balloonangioplasty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may laser angioplasty be of use in thetreatment of lesions that are difficult to dilate?. ### Response: balloonangioplasty.


Instruction: What might be considered to avoid slippage-induced coronary artery trauma dur-ing PCI for in-stent restenosis?

Output: Cutting balloon angioplasty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What might be considered to avoid slippage-induced coronary artery trauma dur-ing PCI for in-stent restenosis?. ### Response: Cutting balloon angioplasty.


Instruction: What should be avoided during PCI for in-stent restenosis or ostial lesions in sidebranches?

Output: slippage-induced coronary artery trauma

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be avoided during PCI for in-stent restenosis or ostial lesions in sidebranches?. ### Response: slippage-induced coronary artery trauma.


Instruction: What type of angioplasty should not be per-formed routinely During PCI?

Output: Cutting balloon

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of angioplasty should not be per-formed routinely During PCI?. ### Response: Cutting balloon.


Instruction: What was more efficacious than bal-Levine and al 2011 ACCF/AHA/SCAI PCI Guideline e603Downloaded from http://ahajournals.org by on May 1, 2023?

Output: cutting balloon angioplasty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was more efficacious than bal-Levine and al 2011 ACCF/AHA/SCAI PCI Guideline e603Downloaded from http://ahajournals.org by on May 1, 2023?. ### Response: cutting balloon angioplasty.


Instruction: What can exacerbate ischemia in patients treated with nitrates?

Output: profound hypotension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can exacerbate ischemia in patients treated with nitrates?. ### Response: profound hypotension.


Instruction: What type of patients are at increased risk of hypertension?

Output: the elderly

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of patients are at increased risk of hypertension?. ### Response: the elderly.


Instruction: What is a problem even within the first 24 hours?

Output: Nitrate tolerance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a problem even within the first 24 hours?. ### Response: Nitrate tolerance.


Instruction: What should be implemented to minimize nitrate tolerance?

Output: reducing intravenous doses and implementing intermittent dosing by nonintravenous routes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be implemented to minimize nitrate tolerance?. ### Response: reducing intravenous doses and implementing intermittent dosing by nonintravenous routes.


Instruction: What is a cornerstone of ACS treatment?

Output: β-Blockersβ-Blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a cornerstone of ACS treatment?. ### Response: β-Blockersβ-Blockers.


Instruction: What are -Blockers able to reduce?

Output: heart rate and BP and thus myo-cardial oxygen demand

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are -Blockers able to reduce?. ### Response: heart rate and BP and thus myo-cardial oxygen demand.


Instruction: What was one of the first therapies shown to reduce infarct size?

Output: β-Blockersβ-Blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was one of the first therapies shown to reduce infarct size?. ### Response: β-Blockersβ-Blockers.


Instruction: What reduces early sudden death after MI via antiarrhythmic effects and by preventing myocardial rupture?

Output: β-Blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What reduces early sudden death after MI via antiarrhythmic effects and by preventing myocardial rupture?. ### Response: β-Blockers.


Instruction: In patients with STEMI, the long-term benefits of -blocker administration have been shown in what?

Output: multiple trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with STEMI, the long-term benefits of -blocker administration have been shown in what?. ### Response: multiple trials.


Instruction: What has been shown in multiple trials?

Output: Early intravenous β-blockade

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been shown in multiple trials?. ### Response: Early intravenous β-blockade.


Instruction: Routine discharge use of -blockers is now a qual-ity performance measure for patients with what?

Output: hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Routine discharge use of -blockers is now a qual-ity performance measure for patients with what?. ### Response: hypertension.


Instruction: What should be initiated early and contin-ued for at least 3 years after ACS?

Output: β-blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be initiated early and contin-ued for at least 3 years after ACS?. ### Response: β-blockers.


Instruction: What did early intravenous -blockade reduce in a number of trials performed in the fibrinolytic era?

Output: mortality or recurrent MI192

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did early intravenous -blockade reduce in a number of trials performed in the fibrinolytic era?. ### Response: mortality or recurrent MI192.


Instruction: What was used as routine therapy in ACS for many years?

Output: Early intravenous β-blockade

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was used as routine therapy in ACS for many years?. ### Response: Early intravenous β-blockade.


Instruction: What trial has led to a revision of the recommendations for intra-venous -blocker use?

Output: arction Trial (COMMIT)/Chinese Cardiac Study (CCC) 2 trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What trial has led to a revision of the recommendations for intra-venous -blocker use?. ### Response: arction Trial (COMMIT)/Chinese Cardiac Study (CCC) 2 trial.


Instruction: How many AMI patients were randomized to the CCC 2 trial?

Output: 45 852

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many AMI patients were randomized to the CCC 2 trial?. ### Response: 45 852.


Instruction: How many AMI patients were randomized to -blockers?

Output: 45 852

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many AMI patients were randomized to -blockers?. ### Response: 45 852.


Instruction: What were the coprimary outcomes of the study?

Output: death, reinfarction, or cardiac arrest and death resulting from any cause

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the coprimary outcomes of the study?. ### Response: death, reinfarction, or cardiac arrest and death resulting from any cause.


Instruction: How long did it take for the outcome to be reduced with metoprolol?

Output: 4 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for the outcome to be reduced with metoprolol?. ### Response: 4 weeks.


Instruction: What did the COMMIT trial show about rein-farction and ventricular fibrillation?

Output: a reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the COMMIT trial show about rein-farction and ventricular fibrillation?. ### Response: a reduction.


Instruction: What was the increase in cardiogenic shock with intravenous -blocker use?

Output: 5.0% versus 3.9%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the increase in cardiogenic shock with intravenous -blocker use?. ### Response: 5.0% versus 3.9%).


Instruction: What percentage of patients had intravenous -blocker use?

Output: 45 852

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients had intravenous -blocker use?. ### Response: 45 852.


Instruction: What was the highest risk of shock in the first 2 days of hospitalization?

Output: excess

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the highest risk of shock in the first 2 days of hospitalization?. ### Response: excess.


Instruction: Patients with evidence of hemo-dynamic instability or borderline hemodynamics at presenta-tion had what risk?

Output: excess risk of shock

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with evidence of hemo-dynamic instability or borderline hemodynamics at presenta-tion had what risk?. ### Response: excess risk of shock.


Instruction: What was the SBP >140 mm Hg?

Output: hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the SBP >140 mm Hg?. ### Response: hypertension.


Instruction: What was there no statistically significant differ?

Output: hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was there no statistically significant differ?. ### Response: hypertension.


Instruction: What was the relative risk of death from CV disease reduced by 18%?

Output: HR: 0.82; 95% CI: 0.68 –0.98

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the relative risk of death from CV disease reduced by 18%?. ### Response: HR: 0.82; 95% CI: 0.68 –0.98.


Instruction: What was reduced by 14%?

Output: deathfrom any cause

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was reduced by 14%?. ### Response: deathfrom any cause.


Instruction: What was the BP of patients with CKD G1 or G2?

Output: SBP 5.3/DBP 2.1 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the BP of patients with CKD G1 or G2?. ### Response: SBP 5.3/DBP 2.1 mm Hg.


Instruction: What was SBP 4.5/DBP 1.8 mm Hg in patientswith CKd G3 –G5?

Output: fall in BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was SBP 4.5/DBP 1.8 mm Hg in patientswith CKd G3 –G5?. ### Response: fall in BP.


Instruction: What percentage of the placebo group were already treated with RASi at baseline?

Output: 49%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the placebo group were already treated with RASi at baseline?. ### Response: 49%.


Instruction: What percentage were on diuretics at baseline in the ADVANCE study?

Output: 25%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage were on diuretics at baseline in the ADVANCE study?. ### Response: 25%.


Instruction: What did diuretics decrease to in the placebo group at the final visit?

Output: 21%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did diuretics decrease to in the placebo group at the final visit?. ### Response: 21%.


Instruction: What may have been due to the addition of the diuretic and/or greater BP lowering?

Output: ﬁts seen in ADVANCE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may have been due to the addition of the diuretic and/or greater BP lowering?. ### Response: ﬁts seen in ADVANCE.


Instruction: What is emerging evidence that MRA have bene ficial effects on?

Output: clinical kidney outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is emerging evidence that MRA have bene ficial effects on?. ### Response: clinical kidney outcomes.


Instruction: How many participants participated in the FIDELIO-DKD study?

Output: 5734

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many participants participated in the FIDELIO-DKD study?. ### Response: 5734.


Instruction: What reduced the risk of composite primary endpoint of GFR decline?

Output: ﬁnerenone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What reduced the risk of composite primary endpoint of GFR decline?. ### Response: ﬁnerenone.


Instruction: What reduced the risk of CV events?

Output: Finerenone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What reduced the risk of CV events?. ### Response: Finerenone.


Instruction: What was the effect offinerenone on SBPlowering modest?

Output: 2 –3 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the effect offinerenone on SBPlowering modest?. ### Response: 2 –3 mm Hg.


Instruction: Why was there a higher risk of hyperkalemia-related events in the study?

Output: its effect on SBPlowering was modest (2 –3 mm Hg),

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was there a higher risk of hyperkalemia-related events in the study?. ### Response: its effect on SBPlowering was modest (2 –3 mm Hg),.


Instruction: What is a hyperkalemia-related event?

Output: SBPlowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a hyperkalemia-related event?. ### Response: SBPlowering.


Instruction: What drug has not been approved for clinical use at the time of writing of this guideline?

Output: ﬁnerenone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug has not been approved for clinical use at the time of writing of this guideline?. ### Response: ﬁnerenone.


Instruction: When was the trial offinerenone published?

Output: after the evidence review cut-off for the guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the trial offinerenone published?. ### Response: after the evidence review cut-off for the guideline.


Instruction: What was the overall quality of the review on antihypertensive therapies in patients with diabetes and CKD, A2 and A3.259?

Output: moderate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the overall quality of the review on antihypertensive therapies in patients with diabetes and CKD, A2 and A3.259?. ### Response: moderate.


Instruction: What were the studies examining the use of RASi therapy exhibiting?

Output: study limitations with unclearallocation concealment for critical and important outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the studies examining the use of RASi therapy exhibiting?. ### Response: study limitations with unclearallocation concealment for critical and important outcomes.


Instruction: Why was the quality of the evidence for CV outcomes lower?

Output: there being fewer events and inconsistent reportingof these outcomes in trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the quality of the evidence for CV outcomes lower?. ### Response: there being fewer events and inconsistent reportingof these outcomes in trials.


Instruction: Why was there fewer events and inconsistent reporting of CV outcomes in trials?

Output: The quality of the evidence was lower for CV outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was there fewer events and inconsistent reporting of CV outcomes in trials?. ### Response: The quality of the evidence was lower for CV outcomes.


Instruction: What study of patients with CKD G1 – G3, A2 had a low quality of evidence?

Output: ADVANCE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What study of patients with CKD G1 – G3, A2 had a low quality of evidence?. ### Response: ADVANCE.


Instruction: Why was the quality of the evidence downgraded?

Output: serious risk ofbias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the quality of the evidence downgraded?. ### Response: serious risk ofbias.


Instruction: Why was there a serious risk ofbias?

Output: unclear allocation concealment, and imprecision

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was there a serious risk ofbias?. ### Response: unclear allocation concealment, and imprecision.


Instruction: What was seen only in the CKDsubgroups when the results were negative in the entire cohort?

Output: diuretics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was seen only in the CKDsubgroups when the results were negative in the entire cohort?. ### Response: diuretics.


Instruction: What is the best evidence for renoprotective effects of RASi therapy in patients with diabetes?

Output: CKDG3–G4, and severely increased albuminuria comes from theIDNT162with its active comparator arm, and from theRENAAL200trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the best evidence for renoprotective effects of RASi therapy in patients with diabetes?. ### Response: CKDG3–G4, and severely increased albuminuria comes from theIDNT162with its active comparator arm, and from theRENAAL200trial.


Instruction: What does the IDNT162 have in its active comparator arm?

Output: best evidence for renoprotective effects of RASi therapyindependent of BP control in patients with diabetes, CKDG3–G4, and severely increased albuminuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the IDNT162 have in its active comparator arm?. ### Response: best evidence for renoprotective effects of RASi therapyindependent of BP control in patients with diabetes, CKDG3–G4, and severely increased albuminuria.


Instruction: The Micro-HOPE studyprovides thebest evidence for patients with moderately increased what?

Output: albuminuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The Micro-HOPE studyprovides thebest evidence for patients with moderately increased what?. ### Response: albuminuria.


Instruction: What is the name of the 2019 AHA/ACC High Blood Pressure Performance and Quality MeasuresCirc Cardiovasc Qual Outcomes. 2019;12:e000057?

Output: Casey et al;

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2019 AHA/ACC High Blood Pressure Performance and Quality MeasuresCirc Cardiovasc Qual Outcomes. 2019;12:e000057?. ### Response: Casey et al;.


Instruction: What was reduced in team-based hypertension care involving nurse or pharmacist intervention?

Output: SBP and DBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was reduced in team-based hypertension care involving nurse or pharmacist intervention?. ### Response: SBP and DBP.


Instruction: What did systematic reviews of team-based care for patients with primary hypertension show reduced in?

Output: SBP and DBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did systematic reviews of team-based care for patients with primary hypertension show reduced in?. ### Response: SBP and DBP.


Instruction: What did the systematic reviews show improvements in in BP control, appointment keeping, and hypertension?

Output: medication adherence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the systematic reviews show improvements in in BP control, appointment keeping, and hypertension?. ### Response: medication adherence.


Instruction: What type of care can be defined by numerous structures that are functional and improve care in various settings and patient populations?

Output: Team-based care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of care can be defined by numerous structures that are functional and improve care in various settings and patient populations?. ### Response: Team-based care.


Instruction: What do team-based care try to provide?

Output: a division of labor and improved workflows

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do team-based care try to provide?. ### Response: a division of labor and improved workflows.


Instruction: What do disease-management-specific programs and protocols help identify?

Output: areas to improve workflow and patient-centered care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do disease-management-specific programs and protocols help identify?. ### Response: areas to improve workflow and patient-centered care.


Instruction: What is the primary goal of team-based care?

Output: to optimize the timely and effective use of information, skills, and resources by teams of health care professionals for the purpose of enhancing the quality and safety of patient care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary goal of team-based care?. ### Response: to optimize the timely and effective use of information, skills, and resources by teams of health care professionals for the purpose of enhancing the quality and safety of patient care.


Instruction: What is the primary goal of medical teamwork?

Output: enhancing the quality and safety of patient care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary goal of medical teamwork?. ### Response: enhancing the quality and safety of patient care.


Instruction: What are the primary goals of the medical team work?

Output: enhancing the quality and safety of patient care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the primary goals of the medical team work?. ### Response: enhancing the quality and safety of patient care.


Instruction: How are the recommendations for the 2017 Hypertension Clinical Practice Guidelines?

Output: 200Clinical Recommendations 2017 Hypertension Clinical Practice Guidelines4  Recommendation for Structured, Team-Based Care Interventions for Hypertension Control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are the recommendations for the 2017 Hypertension Clinical Practice Guidelines?. ### Response: 200Clinical Recommendations 2017 Hypertension Clinical Practice Guidelines4  Recommendation for Structured, Team-Based Care Interventions for Hypertension Control.


Instruction: What type of care approach is recommended for adults with hypertension?

Output: team-based

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of care approach is recommended for adults with hypertension?. ### Response: team-based.


Instruction: What is the class of evidence for a team-based care approach?

Output: Class 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the class of evidence for a team-based care approach?. ### Response: Class 1.


Instruction: How old are older adults with hypertension?

Output: ≥65 y of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old are older adults with hypertension?. ### Response: ≥65 y of age.


Instruction: What are reasonable decisions regarding intensity of BP lowering and choice of antihypertensive drugs?

Output: clinical judgment, patient preference, and a team-based approach to assess risk/benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are reasonable decisions regarding intensity of BP lowering and choice of antihypertensive drugs?. ### Response: clinical judgment, patient preference, and a team-based approach to assess risk/benefit.


Instruction: What should follow-up and monitoring include after initiation of drug therapy?

Output: systematic strategies to help improve BP , including use of HBPM, team-based care, and telehealth strategies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should follow-up and monitoring include after initiation of drug therapy?. ### Response: systematic strategies to help improve BP , including use of HBPM, team-based care, and telehealth strategies.


Instruction: What should include systematic strategies to help improve BP?

Output: Follow-up and monitoring after initiation of drug therapy for hypertension control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should include systematic strategies to help improve BP?. ### Response: Follow-up and monitoring after initiation of drug therapy for hypertension control.


Instruction: What is the acronym for American College of Cardiology?

Output: ACC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for American College of Cardiology?. ### Response: ACC.


Instruction: What does AHA stand for?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does AHA stand for?. ### Response: American Heart Association.


Instruction: AHRQ stands for Agency for Healthcare Research and Quality.

Output: College of Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: AHRQ stands for Agency for Healthcare Research and Quality.. ### Response: College of Cardiology.


Instruction: What is the acronym for diastolic blood pressure?

Output: DBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for diastolic blood pressure?. ### Response: DBP.


Instruction: What does EHR stand for?

Output: electronic health record

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does EHR stand for?. ### Response: electronic health record.


Instruction: Which acronym stands for home blood pressure monitoring?

Output: HBPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which acronym stands for home blood pressure monitoring?. ### Response: HBPM.


Instruction: What does systolic blood pressure measure?

Output: SBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does systolic blood pressure measure?. ### Response: SBP.


Instruction: When was Appendix A downloaded from http://ahajournals.org?

Output: May 3, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Appendix A downloaded from http://ahajournals.org?. ### Response: May 3, 2023.


Instruction: What did the ACCORD trial show that lowering the BP target did not reduce the rate of?

Output: the composite outcome of fatal and non-fatal major cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the ACCORD trial show that lowering the BP target did not reduce the rate of?. ### Response: the composite outcome of fatal and non-fatal major cardiovascular events.


Instruction: What was the risk of lowering BP 120 mm Hg?

Output: greater risk of adverse events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk of lowering BP 120 mm Hg?. ### Response: greater risk of adverse events.


Instruction: What was the primary outcome benefit of the ACCORD trial?

Output: stroke risk reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary outcome benefit of the ACCORD trial?. ### Response: stroke risk reduction.


Instruction: What is the relationship of SBP with CVD risk continuous across levels?

Output: The relationship of SBP with CVD risk is continuous across levels of SBP and similar across groups that differ in level of absolute risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the relationship of SBP with CVD risk continuous across levels?. ### Response: The relationship of SBP with CVD risk is continuous across levels of SBP and similar across groups that differ in level of absolute risk.


Instruction: What is continuous across levels of SBP and similar across groups that differ in level of absolute risk?

Output: The relationship of SBP with CVD risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is continuous across levels of SBP and similar across groups that differ in level of absolute risk?. ### Response: The relationship of SBP with CVD risk.


Instruction: The relative risk reduction attributable to BP-lowering medication therapy is consistent across the range of what?

Output: absolute risk observed in trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The relative risk reduction attributable to BP-lowering medication therapy is consistent across the range of what?. ### Response: absolute risk observed in trials.


Instruction: What does HOPE-3 stand for?

Output: Heart Outcomes Prevention Evaluation-3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does HOPE-3 stand for?. ### Response: Heart Outcomes Prevention Evaluation-3.


Instruction: What is the name of the BP trial?

Output: HOPE-3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the BP trial?. ### Response: HOPE-3.


Instruction: What is HOPE-3?

Output: Heart Outcomes Prevention Evaluation-3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is HOPE-3?. ### Response: Heart Outcomes Prevention Evaluation-3.


Instruction: What was the average age of the participants in the BP Trial?

Output: 66 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the average age of the participants in the BP Trial?. ### Response: 66 years.


Instruction: How much CVD event rate did the participants have during 5.6 years of follow up?

Output: 3.8%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much CVD event rate did the participants have during 5.6 years of follow up?. ### Response: 3.8%.


Instruction: What was the average SBP of patients with hypertension?

Output: >140 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the average SBP of patients with hypertension?. ### Response: >140 mm Hg.


Instruction: What is the CVD risk during the 5.6 years of follow-up?

Output: 6.5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the CVD risk during the 5.6 years of follow-up?. ### Response: 6.5%.


Instruction: Why has the treatment of hypertension with-out elevated risk been systematically under-studied?

Output: lower-risk groups would require prolonged follow-up to have a sufficient number of clinical events to provide useful outcomes data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why has the treatment of hypertension with-out elevated risk been systematically under-studied?. ### Response: lower-risk groups would require prolonged follow-up to have a sufficient number of clinical events to provide useful outcomes data.


Instruction: Why would lower-risk groups require prolonged follow-up to have a sufficient number of clinical events to provide useful outcomes data?

Output: The treatment of patients with hypertension with-out elevated risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why would lower-risk groups require prolonged follow-up to have a sufficient number of clinical events to provide useful outcomes data?. ### Response: The treatment of patients with hypertension with-out elevated risk.


Instruction: There is clinical trial evidence that both drug and nondrug therapy will interrupt the pro-gressive course of hypertension, but there is no trial evi-dence that this treatment decreases what morbidity?

Output: CVD morbidity and mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is clinical trial evidence that both drug and nondrug therapy will interrupt the pro-gressive course of hypertension, but there is no trial evi-dence that this treatment decreases what morbidity?. ### Response: CVD morbidity and mortality.


Instruction: What is the clinical trial evidence strongest for in this population?

Output: a target BP of 140/90 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the clinical trial evidence strongest for in this population?. ### Response: a target BP of 140/90 mm Hg.