Instruction: When did Circulation. 2013;128:532–40.

Output: therapy for the treatment of prosthetic heart valve thrombosis in pregnancy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circulation. 2013;128:532–40.. ### Response: therapy for the treatment of prosthetic heart valve thrombosis in pregnancy.


Instruction: What was the TROIA trial?

Output: thrombolytic regimens for prosthetic valve thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the TROIA trial?. ### Response: thrombolytic regimens for prosthetic valve thrombosis.


Instruction: What is the name of the TROIA trial?

Output: thrombolytic regimens for prosthetic valve thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the TROIA trial?. ### Response: thrombolytic regimens for prosthetic valve thrombosis.


Instruction: How many cases were included in the single-centre study of prosthetic heart valve obstruction?

Output: 263

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many cases were included in the single-centre study of prosthetic heart valve obstruction?. ### Response: 263.


Instruction: What is Roudaut's title?

Output: Roudaut M-F

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Roudaut's title?. ### Response: Roudaut M-F.


Instruction: What improves risk assessment of thrombolysis of prosthetic valve throm-bosis?

Output: Transesophageal echocardiogra-phy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What improves risk assessment of thrombolysis of prosthetic valve throm-bosis?. ### Response: Transesophageal echocardiogra-phy.


Instruction: What is an effective and safe therapy in stuck mitral valves?

Output: Thrombolysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an effective and safe therapy in stuck mitral valves?. ### Response: Thrombolysis.


Instruction: What is an effective and safe therapy in stuck mitral valves with delayed presentation and hemodynamically unstable patients?

Output: Thrombolysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an effective and safe therapy in stuck mitral valves with delayed presentation and hemodynamically unstable patients?. ### Response: Thrombolysis.


Instruction: What is a single centre study?

Output: 263 cases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a single centre study?. ### Response: 263 cases.


Instruction: Cardiol Res. 2018;9:161–4.

Output: Bade AS, Shaikh SSA, Khemani H, et al. Thrombolysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cardiol Res. 2018;9:161–4.. ### Response: Bade AS, Shaikh SSA, Khemani H, et al. Thrombolysis.


Instruction: What are mechanical valves in the pul-monary position?

Output: an international retrospective analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are mechanical valves in the pul-monary position?. ### Response: an international retrospective analysis.


Instruction: In the pul-monary position: an international retrospective analysis?

Output: Mechanical valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the pul-monary position: an international retrospective analysis?. ### Response: Mechanical valves.


Instruction: What is the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: 143:e72–e227

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: 143:e72–e227.


Instruction: What are statistical averages and serve as the starting point for shared decision-making?

Output: 101CLINICAL STATEMENTS  AND GUIDELINES

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are statistical averages and serve as the starting point for shared decision-making?. ### Response: 101CLINICAL STATEMENTS  AND GUIDELINES.


Instruction: What are some factors that affect longevity or quality of life that should be individualized on the basis of patient-specific factors?

Output: comorbid cardiac and noncardiac conditions, frailty, dementia, and other factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some factors that affect longevity or quality of life that should be individualized on the basis of patient-specific factors?. ### Response: comorbid cardiac and noncardiac conditions, frailty, dementia, and other factors.


Instruction: What are some of the factors that influence the choice of implanta-tion approach?

Output: comorbid cardiac and noncardiac conditions, frailty, dementia, and other factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the factors that influence the choice of implanta-tion approach?. ### Response: comorbid cardiac and noncardiac conditions, frailty, dementia, and other factors.


Instruction: What is a shared decision-making process that accounts for the patient’s values and pref-ences?

Output: the choice of implanta-tion approach

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a shared decision-making process that accounts for the patient’s values and pref-ences?. ### Response: the choice of implanta-tion approach.


Instruction: What has demonstrated excellent durability and outcomes for both mechanical and bioprosthetic valves?

Output: SAVR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has demonstrated excellent durability and outcomes for both mechanical and bioprosthetic valves?. ### Response: SAVR.


Instruction: What did earlier RCTs compare SAVR and TAVI in patients with a higher surgical risk include?

Output: only older patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did earlier RCTs compare SAVR and TAVI in patients with a higher surgical risk include?. ### Response: only older patients.


Instruction: How old were surgical risk patients?

Output: mid-80s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old were surgical risk patients?. ### Response: mid-80s.


Instruction: What was the mean age of surgical risk RCTs?

Output: mid-80s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean age of surgical risk RCTs?. ### Response: mid-80s.


Instruction: How many patients were 65 years of age?

Output: 80

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were 65 years of age?. ### Response: 80.


Instruction: What is of higher priority in younger patients?

Output: valve durability

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is of higher priority in younger patients?. ### Response: valve durability.


Instruction: What does a younger patient typically have a longer life expectancy and lower surgical risk?

Output: valve durability

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does a younger patient typically have a longer life expectancy and lower surgical risk?. ### Response: valve durability.


Instruction: What is the most prudent course to recommend SAVR for adults 65 years of age unless life expectancy is limited by comorbid cardiac or noncardiac condi-tions?

Output: TAVI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most prudent course to recommend SAVR for adults 65 years of age unless life expectancy is limited by comorbid cardiac or noncardiac condi-tions?. ### Response: TAVI.


Instruction: What is the final choice of implantation approach based on?

Output: a shared decision-making process

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the final choice of implantation approach based on?. ### Response: a shared decision-making process.


Instruction: What are the indications for and against each approach?

Output: effective approaches to AVR in adults 65 to 80 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the indications for and against each approach?. ### Response: effective approaches to AVR in adults 65 to 80 years of age.


Instruction: What is the need for and risks associated with valve reintervention?

Output: potential

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the need for and risks associated with valve reintervention?. ### Response: potential.


Instruction: There are no data for the use of what in patients 65 years of age212?

Output: AVR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There are no data for the use of what in patients 65 years of age212?. ### Response: AVR.


Instruction: What are both effective approaches to AVR in adults 65 to 80 years old?

Output: SAVR and TAVI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are both effective approaches to AVR in adults 65 to 80 years old?. ### Response: SAVR and TAVI.


Instruction: Patients enrolled in RCTs of TAVI versus SAVR had what?

Output: high-velocity severe AS (Stage D1).

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients enrolled in RCTs of TAVI versus SAVR had what?. ### Response: high-velocity severe AS (Stage D1)..


Instruction: What did patients enrolled in RCTs of TAVI versus SAVR have?

Output: high-velocity severe AS (Stage D1).

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did patients enrolled in RCTs of TAVI versus SAVR have?. ### Response: high-velocity severe AS (Stage D1)..


Instruction: What is less robust data from observational studies and regis-try data encouraging with regard to TAVI for symptomatic patients with low-flow, low-gradi-ent severe AS?

Output: encouraging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is less robust data from observational studies and regis-try data encouraging with regard to TAVI for symptomatic patients with low-flow, low-gradi-ent severe AS?. ### Response: encouraging.


Instruction: What does TAVI have a slightly lower mortality risk?

Output: shorter hos-pital length of stay

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does TAVI have a slightly lower mortality risk?. ### Response: shorter hos-pital length of stay.


Instruction: What is associated with a shorter hos-pital length of stay?

Output: TAVI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with a shorter hos-pital length of stay?. ### Response: TAVI.


Instruction: What type of imaging is recommended after aneurysm repair?

Output: immediate cerebrovas-cular imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of imaging is recommended after aneurysm repair?. ### Response: immediate cerebrovas-cular imaging.


Instruction: What is the class of Evi-dence B?

Output: Class IIb

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the class of Evi-dence B?. ### Response: Class IIb.


Instruction: When is immediate cerebrovascular imaging recommended?

Output: After any aneurysm repair

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is immediate cerebrovascular imaging recommended?. ### Response: After any aneurysm repair.


Instruction: What is the class of aneurysm that may require treatment?

Output: International Subarachnoid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the class of aneurysm that may require treatment?. ### Response: International Subarachnoid.


Instruction: What is a new recommendation for recurrence of aSAH?

Output: intellectual impairment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a new recommendation for recurrence of aSAH?. ### Response: intellectual impairment.


Instruction: In what countries have mortality rates from aSAHA declined over the past 25 years?

Output: industrialized

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what countries have mortality rates from aSAHA declined over the past 25 years?. ### Response: industrialized.


Instruction: How many years did one study in the US report a decrease of /H110151%per year from 1979 to 1994?

Output: 60

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many years did one study in the US report a decrease of /H110151%per year from 1979 to 1994?. ### Response: 60.


Instruction: What did other studies show that casefatality rates decreased from 57% in the mid-1970s to 42% in the middle-1980s?

Output: 60

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did other studies show that casefatality rates decreased from 57% in the mid-1970s to 42% in the middle-1980s?. ### Response: 60.


Instruction: What is the median Mortality rate in epidemiological studies from the United States?

Output: 32%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the median Mortality rate in epidemiological studies from the United States?. ### Response: 32%.


Instruction: What percentage of Mortality rates are found in Japan?

Output: 27%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of Mortality rates are found in Japan?. ### Response: 27%.


Instruction: What is the mean age of patients presenting with aSAH?

Output: increas-ing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the mean age of patients presenting with aSAH?. ### Response: increas-ing.


Instruction: What are the numbers based on studies that did not fully account for?

Output: cases of prehospital death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the numbers based on studies that did not fully account for?. ### Response: cases of prehospital death.


Instruction: What has been noted to have a negative impact onsurvival rates?

Output: The mean age of patients presenting with aSAH is increas-ing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been noted to have a negative impact onsurvival rates?. ### Response: The mean age of patients presenting with aSAH is increas-ing.


Instruction: What may also play a role in the variable rates of mortality?

Output: Sex and racial variations in survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may also play a role in the variable rates of mortality?. ### Response: Sex and racial variations in survival.


Instruction: What is highermortality in blacks, American Indians/Alaskan Natives andPacific Islanders than in whites?

Output: higher mortality in women than in men9,11,60

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is highermortality in blacks, American Indians/Alaskan Natives andPacific Islanders than in whites?. ### Response: higher mortality in women than in men9,11,60.


Instruction: What offer much less infor-mation about the functional outcome of survivors?

Output: Available population-based studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What offer much less infor-mation about the functional outcome of survivors?. ### Response: Available population-based studies.


Instruction: What is the modified Rankin Scale used for?

Output: lifestyle restrictions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the modified Rankin Scale used for?. ### Response: lifestyle restrictions.


Instruction: What percentage of patients in the ISAT show significant lifestyle restrictions?

Output: 12%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients in the ISAT show significant lifestyle restrictions?. ### Response: 12%.


Instruction: How long after aSAH are patients functionally dependent?

Output: 1 year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after aSAH are patients functionally dependent?. ### Response: 1 year.


Instruction: How long after aSAH is cognitive impairment very prevalent?

Output: 1 year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after aSAH is cognitive impairment very prevalent?. ### Response: 1 year.


Instruction: What scales are relatively insensitive to cognitive impairment, behavioral changes, social readjustment, and energy level?

Output: scales

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What scales are relatively insensitive to cognitive impairment, behavioral changes, social readjustment, and energy level?. ### Response: scales.


Instruction: What is very prevalent after aSAH?

Output: intellectual impairment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is very prevalent after aSAH?. ### Response: intellectual impairment.


Instruction: What does cognitive function tend to improve after the first year?

Output: 64

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does cognitive function tend to improve after the first year?. ### Response: 64.


Instruction: Cognitive impairment is stillpresent in /H1101520% of what?

Output: aSAH patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cognitive impairment is stillpresent in /H1101520% of what?. ### Response: aSAH patients.


Instruction: Atrial fibrillation: antithrombotic therapy and prevention of throm-bosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines.

Output: Chest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atrial fibrillation: antithrombotic therapy and prevention of throm-bosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines.. ### Response: Chest.


Instruction: Chest. 2012;141:e531S–75S. S7.4-17 What is a novel user-friendly score called?

Output: HAS-BLED

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Chest. 2012;141:e531S–75S. S7.4-17 What is a novel user-friendly score called?. ### Response: HAS-BLED.


Instruction: What does HAS-BLED stand for?

Output: user-friendly score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does HAS-BLED stand for?. ### Response: user-friendly score.


Instruction: What is the Euro Heart Survey?

Output: A novel user-friendly score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Euro Heart Survey?. ### Response: A novel user-friendly score.


Instruction: What is Digoxin and mortality in patients with atrial fibrillation?

Output: Lopes RD, Rordorf R, De Ferrari GM, et al. Digoxin and mortality in patients with atrial fibrillation. J Am Coll Cardiol. 2018;71:1063–74

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Digoxin and mortality in patients with atrial fibrillation?. ### Response: Lopes RD, Rordorf R, De Ferrari GM, et al. Digoxin and mortality in patients with atrial fibrillation. J Am Coll Cardiol. 2018;71:1063–74.


Instruction: When was the download from http://ahajournals.org?

Output: April 23, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the download from http://ahajournals.org?. ### Response: April 23, 2023.


Instruction: Research in Infectious Diseases. Neurological complications of infective endocarditis: risk factors, outcome, and impact of what?

Output: cardiac surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Research in Infectious Diseases. Neurological complications of infective endocarditis: risk factors, outcome, and impact of what?. ### Response: cardiac surgery.


Instruction: Circulation. 2013;127:2272–2284. doi: 10.1161/CIRCULATIONAHA.112.000813 461.

Output: Research in Infectious Diseases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation. 2013;127:2272–2284. doi: 10.1161/CIRCULATIONAHA.112.000813 461.. ### Response: Research in Infectious Diseases.


Instruction: How long was the experience in a teaching hospital?

Output: 17-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the experience in a teaching hospital?. ### Response: 17-year.


Instruction: How long was the experience of infective endocarditis?

Output: 17-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the experience of infective endocarditis?. ### Response: 17-year.


Instruction: Where did the experience come from?

Output: Finland

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where did the experience come from?. ### Response: Finland.


Instruction: What was the result of the 17-year experience?

Output: Neurologic manifestations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the result of the 17-year experience?. ### Response: Neurologic manifestations.


Instruction: What are factors for “major” em-bolic events in hospitalized patients with infective endocarditis?

Output: diagnosis, antimicrobial therapy, and management of complications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are factors for “major” em-bolic events in hospitalized patients with infective endocarditis?. ### Response: diagnosis, antimicrobial therapy, and management of complications.


Instruction: What is the name of the journal that published in 2003?

Output: Am Heart J

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that published in 2003?. ### Response: Am Heart J.


Instruction: What is the acronym for Endocarditis and Kawasaki Disease?

Output: Rheumatic Fever

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Endocarditis and Kawasaki Disease?. ### Response: Rheumatic Fever.


Instruction: What are the acronyms for Council on Cardiovascular Disease in the Young and American Heart Association?

Output: Councils on Clinical Cardiology, Stroke, and Cardiovascular Surgery and Anesthesia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the acronyms for Council on Cardiovascular Disease in the Young and American Heart Association?. ### Response: Councils on Clinical Cardiology, Stroke, and Cardiovascular Surgery and Anesthesia.


Instruction: What is endocarditis?

Output: infective

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is endocarditis?. ### Response: infective.


Instruction: What is a statement for healthcare professionals from the Committee on Rheumatic Fever and Kawasaki Disease?

Output: Infective endocardi-tis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a statement for healthcare professionals from the Committee on Rheumatic Fever and Kawasaki Disease?. ### Response: Infective endocardi-tis.


Instruction: When will the statement be available for download?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When will the statement be available for download?. ### Response: April 28, 2023.


Instruction: Who published the 2018 Cholesterol Clinical Practice Guidelines?

Output: Grundy et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2018 Cholesterol Clinical Practice Guidelines?. ### Response: Grundy et al.


Instruction: When did Grundy and colleagues publish the 2018 CHOLOSTERO CLINICAL STATEMENTS AND GUIDELINES?

Output: June 18/25, 2019

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Grundy and colleagues publish the 2018 CHOLOSTERO CLINICAL STATEMENTS AND GUIDELINES?. ### Response: June 18/25, 2019.


Instruction: What did Loprinzi PD and Addoh O do to predict all-cause and cardiovascular disease-specific mortality?

Output: Predictive validity of the American College of Cardiology/American Heart Association pooled cohort equa-tions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Loprinzi PD and Addoh O do to predict all-cause and cardiovascular disease-specific mortality?. ### Response: Predictive validity of the American College of Cardiology/American Heart Association pooled cohort equa-tions.


Instruction: What did Mortensen MB, Afzal S, Nordestgaard BG, et al. compare with risk-based approaches to guide statin therapy?

Output: ACC/AHA risk-based approach versus trial-based approaches

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Mortensen MB, Afzal S, Nordestgaard BG, et al. compare with risk-based approaches to guide statin therapy?. ### Response: ACC/AHA risk-based approach versus trial-based approaches.


Instruction: What was the name of the national prospective cohort study of adults in the United States?

Output: American College of Cardiology/American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the national prospective cohort study of adults in the United States?. ### Response: American College of Cardiology/American Heart Association.


Instruction: What is the difference between ACC/AHA and ESC/EAS guidelines for primary prevention with statins in non-diabetic Europeans?

Output: superior

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between ACC/AHA and ESC/EAS guidelines for primary prevention with statins in non-diabetic Europeans?. ### Response: superior.


Instruction: What was the Copenhagen General Population Study?

Output: statins in non-diabetic Europeans

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the Copenhagen General Population Study?. ### Response: statins in non-diabetic Europeans.


Instruction: What does MESA stand for?

Output: Multi-Ethnic Study of Atherosclerosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does MESA stand for?. ### Response: Multi-Ethnic Study of Atherosclerosis.


Instruction: What is the acronym for the Multi-Ethnic Study of Atherosclerosis?

Output: MESA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the Multi-Ethnic Study of Atherosclerosis?. ### Response: MESA.


Instruction: What is the name of the multiethnic population in which the ath-erosclerotic cardiovascular risk equation is accurate?

Output: Multi-Ethnic Study of Atherosclerosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multiethnic population in which the ath-erosclerotic cardiovascular risk equation is accurate?. ### Response: Multi-Ethnic Study of Atherosclerosis.


Instruction: When did the J Am Coll Cardiol. 201667:2118–30.

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the J Am Coll Cardiol. 201667:2118–30.. ### Response: 2016.


Instruction: What is a risk factor for car -diovascular disease in patients?

Output: sarcoidosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for car -diovascular disease in patients?. ### Response: sarcoidosis.


Instruction: What is the risk of car -diovascular disease in patients with sarcoidosis?

Output: estimate accurately

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of car -diovascular disease in patients with sarcoidosis?. ### Response: estimate accurately.


Instruction: What study predicts the 30-year risk of cardiovascular disease?

Output: Framingham Heart Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What study predicts the 30-year risk of cardiovascular disease?. ### Response: Framingham Heart Study.


Instruction: How long did the Framingham Heart Study last?

Output: 30-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the Framingham Heart Study last?. ### Response: 30-year.


Instruction: What is a risk factor burden at 50 years of age?

Output: Prediction of lifetime risk for cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor burden at 50 years of age?. ### Response: Prediction of lifetime risk for cardiovascular disease.


Instruction: What is the acronym for Risk-Enhancing Factors?

Output: S4.4.1.3-1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Risk-Enhancing Factors?. ### Response: S4.4.1.3-1.


Instruction: Where can you find the ASCVD Risk Predictor Plus?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find the ASCVD Risk Predictor Plus?. ### Response: http://tools.acc.org/ASCVD-Risk-Estimator-Plus/#!/calculate/estimate/..


Instruction: What is the ACC/AHA guideline on the treatment of blood cholesterol to reduce ath-erosclerotic cardiovascular risk in adults?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ACC/AHA guideline on the treatment of blood cholesterol to reduce ath-erosclerotic cardiovascular risk in adults?. ### Response: 2013.


Instruction: What is a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines?

Output: 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce ath-erosclerotic cardiovascular risk in adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines?. ### Response: 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce ath-erosclerotic cardiovascular risk in adults.


Instruction: What is the name of the Task Force on Practice Guidelines?

Output: American College of Cardiology/American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Practice Guidelines?. ### Response: American College of Cardiology/American Heart Association.


Instruction: When was the Circulation.129:S1–45. S4.4.1.3-3?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circulation.129:S1–45. S4.4.1.3-3?. ### Response: 2014.


Instruction: What is lowering cholesterol in intermediate-risk persons without cardiovascular disease?

Output: Cholesterol lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is lowering cholesterol in intermediate-risk persons without cardiovascular disease?. ### Response: Cholesterol lowering.


Instruction: Where is the N Engl J Med?

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the N Engl J Med?. ### Response: 2016.


Instruction: What does coro-nary artery calcium testing do for statin candidates?

Output: Implications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does coro-nary artery calcium testing do for statin candidates?. ### Response: Implications.


Instruction: What does e24SCHEST Supplement focus on?

Output: parenteral anticoagulants in current use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does e24SCHEST Supplement focus on?. ### Response: parenteral anticoagulants in current use.


Instruction: What do indirect anticoagulants whose activity is mediated by plasma cofactors do?

Output: do not require plasma cofactors to express their activity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do indirect anticoagulants whose activity is mediated by plasma cofactors do?. ### Response: do not require plasma cofactors to express their activity.


Instruction: What type of anticoagulants do not require plasma cofactors to express their activity?

Output: direct anticoagulants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of anticoagulants do not require plasma cofactors to express their activity?. ### Response: direct anticoagulants.


Instruction: What are indirect parenteral anticoagulant in current use?

Output: heparin, low-molecular-weight-heparins (LMWHs), fondaparinux, and danaparoid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are indirect parenteral anticoagulant in current use?. ### Response: heparin, low-molecular-weight-heparins (LMWHs), fondaparinux, and danaparoid.


Instruction: LMWHs, fondaparinux, and danaparoid are examples of what?

Output: low-molecular-weight-heparins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: LMWHs, fondaparinux, and danaparoid are examples of what?. ### Response: low-molecular-weight-heparins.


Instruction: AT is an endogenous inhibitor of what substance?

Output: var-ious activated clotting factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: AT is an endogenous inhibitor of what substance?. ### Response: var-ious activated clotting factors.


Instruction: What is the name of the endogenous inhibitor of var-ious activated clotting factors?

Output: antithrombin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the endogenous inhibitor of var-ious activated clotting factors?. ### Response: antithrombin.


Instruction: What do the parenteral direct anticoagulants in current use all target?

Output: thrombin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do the parenteral direct anticoagulants in current use all target?. ### Response: thrombin.


Instruction: How long ago did McLean 1 discover that heparin has anticoagulant properties?

Output: More than 90 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long ago did McLean 1 discover that heparin has anticoagulant properties?. ### Response: More than 90 years.


Instruction: What did Brinkhous and associates 2 demonstrate?

Output: heparin requires a plasma cofactor to express its anticoagulant activity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Brinkhous and associates 2 demonstrate?. ### Response: heparin requires a plasma cofactor to express its anticoagulant activity.


Instruction: How did Mclean 1 demonstrate that HEparin requires a plasma cofactor to express its anti-coagulant activity?

Output: unique pentasaccharide sequence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Mclean 1 demonstrate that HEparin requires a plasma cofactor to express its anti-coagulant activity?. ### Response: unique pentasaccharide sequence.


Instruction: What describes the pharmacology of approved parenteral anticoagulants?

Output: This article

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What describes the pharmacology of approved parenteral anticoagulants?. ### Response: This article.


Instruction: What is UFH?

Output: unfractionated heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is UFH?. ### Response: unfractionated heparin.


Instruction: What binds to antithrombin via a unique pentasaccharide sequence?

Output: UFH is a heterogeneous mixture of glycosaminoglycans

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What binds to antithrombin via a unique pentasaccharide sequence?. ### Response: UFH is a heterogeneous mixture of glycosaminoglycans.


Instruction: What catalyzes the inactivation of factor Xa and other clotting enzymes?

Output: UFH is a heterogeneous mixture of glycosaminoglycans

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What catalyzes the inactivation of factor Xa and other clotting enzymes?. ### Response: UFH is a heterogeneous mixture of glycosaminoglycans.


Instruction: How does heparin bind to other cells and plasma proteins?

Output: requires a plasma cofactor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does heparin bind to other cells and plasma proteins?. ### Response: requires a plasma cofactor.


Instruction: What is HIT?

Output: heparin-induced thrombocytopenia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is HIT?. ### Response: heparin-induced thrombocytopenia.


Instruction: What is heparin-induced thrombocytopenia?

Output: HIT) and osteo-porosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is heparin-induced thrombocytopenia?. ### Response: HIT) and osteo-porosis.


Instruction: LMWHs have greater inhibitory activity against factor Xa than what other drug?

Output: thrombin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: LMWHs have greater inhibitory activity against factor Xa than what other drug?. ### Response: thrombin.


Instruction: What did MDRD and AASK target instead of SBP or SBP?

Output: mean arterial BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did MDRD and AASK target instead of SBP or SBP?. ### Response: mean arterial BP.


Instruction: What is arterial BP calculated as?

Output: DBPþ1/3/C2pulse pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is arterial BP calculated as?. ### Response: DBPþ1/3/C2pulse pressure.


Instruction: What was the lower target MAP?

Output: <92 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the lower target MAP?. ### Response: <92 mm Hg.


Instruction: What was the MAP target for MDRD?

Output: <107 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the MAP target for MDRD?. ### Response: <107 mm Hg.


Instruction: How many studies did the ERT of theKDIGO 2012 BP guideline find?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies did the ERT of theKDIGO 2012 BP guideline find?. ### Response: 3.


Instruction: How many studies were relevant to the discussion of whether a lower BP target reduced the risk of progression to kidney failure in the presence of proteinuria?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were relevant to the discussion of whether a lower BP target reduced the risk of progression to kidney failure in the presence of proteinuria?. ### Response: 3.


Instruction: What did the 2012 BP guideline conclude was inconclusive?

Output: a lower BP target reduced the risk of progression tokidney failure in the presence of proteinuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the 2012 BP guideline conclude was inconclusive?. ### Response: a lower BP target reduced the risk of progression tokidney failure in the presence of proteinuria.


Instruction: The currentERT review found no effect modi fication according to thepresence of what?

Output: proteinuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The currentERT review found no effect modi fication according to thepresence of what?. ### Response: proteinuria.


Instruction: How many patients had proteinuria >3 g/d but large effect size?

Output: 54 pa-tients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had proteinuria >3 g/d but large effect size?. ### Response: 54 pa-tients.


Instruction: What was the effect modi fication according to the presence of?

Output: baseline proteinuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the effect modi fication according to the presence of?. ### Response: baseline proteinuria.


Instruction: How many RCTs of lowerversus higher BP goals found that intensive BP reduction was associated with a reduction in kidney failure events?

Output: 11

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs of lowerversus higher BP goals found that intensive BP reduction was associated with a reduction in kidney failure events?. ### Response: 11.


Instruction: What was the composite of doubling of serum creatinine and a >50% reduction in renal failure events found?

Output: de ﬁned

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the composite of doubling of serum creatinine and a >50% reduction in renal failure events found?. ### Response: de ﬁned.


Instruction: What did intensive BP control reduce the risk of kidney failure only among those with baseline proteinuria?

Output: >220 mg/g (22mg/mmol).

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did intensive BP control reduce the risk of kidney failure only among those with baseline proteinuria?. ### Response: >220 mg/g (22mg/mmol)..


Instruction: What was the protein -creatinine ratio?

Output: >220 mg/g

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the protein -creatinine ratio?. ### Response: >220 mg/g.


Instruction: What did the MDRD and AASK studies contribute to?

Output: this evidence base

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the MDRD and AASK studies contribute to?. ### Response: this evidence base.


Instruction: What was the DBP target of the REIN-2 study?

Output: <90mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the DBP target of the REIN-2 study?. ### Response: <90mm Hg.


Instruction: How was the eGFR and proteinuria measured in patients with CKD?

Output: 35 ml/min and 3 g/d

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the eGFR and proteinuria measured in patients with CKD?. ### Response: 35 ml/min and 3 g/d.


Instruction: How long did the study last?

Output: 19 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the study last?. ### Response: 19 months.


Instruction: How many participants were in the study?

Output: 338

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many participants were in the study?. ### Response: 338.


Instruction: What was the mean eGFR and proteinuria?

Output: 35 ml/min and 3 g/d

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean eGFR and proteinuria?. ### Response: 35 ml/min and 3 g/d.


Instruction: How many participants were underpow-ered?

Output: 338

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many participants were underpow-ered?. ### Response: 338.


Instruction: What were the differences in achieved SBP and DBP during the intervention phase?

Output: 4 mm Hg and2 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the differences in achieved SBP and DBP during the intervention phase?. ### Response: 4 mm Hg and2 mm Hg.


Instruction: InACCORD and SPRINT, what had few effects?

Output: intensive BP lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: InACCORD and SPRINT, what had few effects?. ### Response: intensive BP lowering.


Instruction: InACCORD, how many CKD patients were there?

Output: few

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: InACCORD, how many CKD patients were there?. ### Response: few.


Instruction: What was the median ACR in SPRINT?

Output: 13 mg/g

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the median ACR in SPRINT?. ### Response: 13 mg/g.


Instruction: In what group was there no difference in progression to ESKD?

Output: ACCORD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what group was there no difference in progression to ESKD?. ### Response: ACCORD.


Instruction: What is ATTEST?

Output: a phase 2, randomised, open-label, blinded endpoint study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ATTEST?. ### Response: a phase 2, randomised, open-label, blinded endpoint study.


Instruction: What is the name of the phase 2 randomised, open-label, blinded endpoint study?

Output: ATTEST

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the phase 2 randomised, open-label, blinded endpoint study?. ### Response: ATTEST.


Instruction: What is the name of the randomized trial of tenecteplase versus alteplasa for acute ischemic stroke?

Output: NOR-TEST

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized trial of tenecteplase versus alteplasa for acute ischemic stroke?. ### Response: NOR-TEST.


Instruction: What is a name for the reversal of a randomized randomized study?

Output: AS-4 Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a name for the reversal of a randomized randomized study?. ### Response: AS-4 Trial.


Instruction: When was the N Engl J Med 366:1099-1107?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the N Engl J Med 366:1099-1107?. ### Response: 2012.


Instruction: Who are the Tenecteplase in Stroke Investigators?

Output: Haley EC Jr, Thompson JL, Grotta JC, Lyden PD, Hemmen TG, Brown DL, Fanale C, Libman R, Kwiatkowski TG, Llinas RH, et al;

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who are the Tenecteplase in Stroke Investigators?. ### Response: Haley EC Jr, Thompson JL, Grotta JC, Lyden PD, Hemmen TG, Brown DL, Fanale C, Libman R, Kwiatkowski TG, Llinas RH, et al;.


Instruction: What is the name of the Phase IIB/III trial?

Output: Tenecteplase in Stroke Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Phase IIB/III trial?. ### Response: Tenecteplase in Stroke Investigators.


Instruction: When did the randomized clinical trial of tenectepase begin?

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the randomized clinical trial of tenectepase begin?. ### Response: 2017.


Instruction: What is NOR-TEST?

Output: Tenecteplase versus alteplase for management of acute ischaemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NOR-TEST?. ### Response: Tenecteplase versus alteplase for management of acute ischaemic stroke.


Instruction: What is the name of the phase 3 trial?

Output: NOR-TEST

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the phase 3 trial?. ### Response: NOR-TEST.


Instruction: What is the name of the study that evaluated intravenous desmoteplase in patients with acute ischaemic stroke?

Output: DIAS Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated intravenous desmoteplase in patients with acute ischaemic stroke?. ### Response: DIAS Study Group.


Instruction: What is another name for MRI perfusion-diffusion weighted imaging or perfusion CT?

Output: DIAS-2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for MRI perfusion-diffusion weighted imaging or perfusion CT?. ### Response: DIAS-2.


Instruction: What is another name for imaging or perfusion CT?

Output: DIAS-2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for imaging or perfusion CT?. ### Response: DIAS-2.


Instruction: What is a prospective, randomised, double-blind, placebo-controlled study?

Output: Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2):

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a prospective, randomised, double-blind, placebo-controlled study?. ### Response: Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2):.


Instruction: When did the Lancet Neurol. 2009:8:141–150?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Lancet Neurol. 2009:8:141–150?. ### Response: 2009.


Instruction: What is the purpose of the DIAS Study Group?

Output: a prospective, randomised, double-blind, placebo-controlled study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of the DIAS Study Group?. ### Response: a prospective, randomised, double-blind, placebo-controlled study.


Instruction: What is a phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase?

Output: The Desmoteplase in Acute Ischemic Stroke Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase?. ### Response: The Desmoteplase in Acute Ischemic Stroke Trial.


Instruction: How long after major artery occlusion stroke does Desmoteplase last?

Output: 3 to 9 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after major artery occlusion stroke does Desmoteplase last?. ### Response: 3 to 9 hours.


Instruction: What is the name of the trial?

Output: NOR-TEST

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the trial?. ### Response: NOR-TEST.


Instruction: How long does it take for Desmotaplasa to treat Acute Ischemic Stroke?

Output: 9-hour

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take for Desmotaplasa to treat Acute Ischemic Stroke?. ### Response: 9-hour.


Instruction: How long after ischaemic stroke is desmoteplase given?

Output: 3-9 h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after ischaemic stroke is desmoteplase given?. ### Response: 3-9 h.


Instruction: What is the name of the drug used to treat stroke in patients with occlusion or high grade ste-nosis?

Output: desmoteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used to treat stroke in patients with occlusion or high grade ste-nosis?. ### Response: desmoteplase.


Instruction: What is the name of the double-blind, randomised, placebo-controlled phase 3 trial in patients with occlusion or high-grade ste-nosis in major cerebral arteries?

Output: DIAS-3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the double-blind, randomised, placebo-controlled phase 3 trial in patients with occlusion or high-grade ste-nosis in major cerebral arteries?. ### Response: DIAS-3.


Instruction: What is the name of the disease that affects large and medium-vessel vasculitis?

Output: Giant cell arteritis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease that affects large and medium-vessel vasculitis?. ### Response: Giant cell arteritis.


Instruction: What are the names of the diseases that affect small and large vessels?

Output: HIV vasculopathy and VZV vasculitis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the diseases that affect small and large vessels?. ### Response: HIV vasculopathy and VZV vasculitis.


Instruction: When was the last time a patient was diagnosed with a large cell arteritis, what was it called?

Output: 2020

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last time a patient was diagnosed with a large cell arteritis, what was it called?. ### Response: 2020.


Instruction: How many patients were diagnosed with Takayasu arthritis in 2020?

Output: 174 709

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were diagnosed with Takayasu arthritis in 2020?. ### Response: 174 709.


Instruction: Mediterr J Rheumatol. 2020;31:174–182. doi: 10.31138/mjr.31.2.174 709. Hellmich B, Agueda A, Monti S, Buttgereit F, de Boysson H, Brouwer E, Cassie R, Dejaco C, et al. 2018 Update of the EULAR recommendations for the management of large vessel vasculitis What is the name of the 2018 Update?

Output: Giant cell arteritis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Mediterr J Rheumatol. 2020;31:174–182. doi: 10.31138/mjr.31.2.174 709. Hellmich B, Agueda A, Monti S, Buttgereit F, de Boysson H, Brouwer E, Cassie R, Dejaco C, et al. 2018 Update of the EULAR recommendations for the management of large vessel vasculitis What is the name of the 2018 Update?. ### Response: Giant cell arteritis.


Instruction: What is large vessel vasculitis?

Output: Immune mechanisms in medium and large-vessel vasculitis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is large vessel vasculitis?. ### Response: Immune mechanisms in medium and large-vessel vasculitis.


Instruction: What is a case series of HIV/AIDS patients?

Output: HIV vasculopathy and VZV vasculitis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a case series of HIV/AIDS patients?. ### Response: HIV vasculopathy and VZV vasculitis.


Instruction: What is arteriopathy of childhood: natural history of vascular stenosis?

Output: Post-varicella

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is arteriopathy of childhood: natural history of vascular stenosis?. ### Response: Post-varicella.


Instruction: Neurology. 2005;64:660–663. doi: 10.212/01.WNL.0000151851.66154.27 712.

Output: Neurology. 2005;64:660–663. doi: 10.1212/01.WNL.0000151851.66154.27 712

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Neurology. 2005;64:660–663. doi: 10.212/01.WNL.0000151851.66154.27 712.. ### Response: Neurology. 2005;64:660–663. doi: 10.1212/01.WNL.0000151851.66154.27 712.


Instruction: What indicates severe AS in a small patient?

Output: an aortic valve area index ≤ 0.6 cm2/m2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates severe AS in a small patient?. ### Response: an aortic valve area index ≤ 0.6 cm2/m2.


Instruction: How is transaortic stroke volume calculated?

Output: Doppler or 2D imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is transaortic stroke volume calculated?. ### Response: Doppler or 2D imaging.


Instruction: What is helpful in measuring a patient's calcium score?

Output: Measurement of a CT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is helpful in measuring a patient's calcium score?. ### Response: Measurement of a CT.


Instruction: What ensures that symptoms are most likely attributable to valve obstruction?

Output: Evaluation for other potential causes of symptoms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What ensures that symptoms are most likely attributable to valve obstruction?. ### Response: Evaluation for other potential causes of symptoms.


Instruction: The survival rate after TAVI is lower in patients with low-flow severe AS than in what other type of AS?

Output: normal-flow severe AS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The survival rate after TAVI is lower in patients with low-flow severe AS than in what other type of AS?. ### Response: normal-flow severe AS.


Instruction: What appears beneficial with an increase in stroke volume and improved survival?

Output: AVR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What appears beneficial with an increase in stroke volume and improved survival?. ### Response: AVR.


Instruction: Exercise testing may be helpful in clarifying what in patients with severe AS?

Output: symptom status

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Exercise testing may be helpful in clarifying what in patients with severe AS?. ### Response: symptom status.


Instruction: When symptoms are provoked by exercise testing, the patient is considered what?

Output: symptomatic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When symptoms are provoked by exercise testing, the patient is considered what?. ### Response: symptomatic.


Instruction: What is a COR 1 recommendation for AVR?

Output: When symptoms are provoked by exercise test-ing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a COR 1 recommendation for AVR?. ### Response: When symptoms are provoked by exercise test-ing.


Instruction: What are symptoms?

Output: symp-toms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are symptoms?. ### Response: symp-toms.


Instruction: How long does the rate of symptom onset occur?

Output: 1 to 2 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does the rate of symptom onset occur?. ### Response: 1 to 2 years.


Instruction: What does a fall of 10 mm Hg in systolic blood pressure from baseline to peak exercise demonstrate?

Output: a significant decrease in exercise tolerance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does a fall of 10 mm Hg in systolic blood pressure from baseline to peak exercise demonstrate?. ### Response: a significant decrease in exercise tolerance.


Instruction: What is a significant decrease in exercise tolerance as compared with age and sex normal standards?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a significant decrease in exercise tolerance as compared with age and sex normal standards?. ### Response: 2.


Instruction: What is less clear about lack of appropriate rise in BP with exercise?

Output: Management of patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is less clear about lack of appropriate rise in BP with exercise?. ### Response: Management of patients.


Instruction: In patients with very severe AS and an aortic velocity 5.0 m/s or mean pressure gradient, what is considered to be a factor in choosing elective AVR?

Output: patient age, avoidance of patient–prosthesis mismatch, anticoagulation issues, and patient preferences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with very severe AS and an aortic velocity 5.0 m/s or mean pressure gradient, what is considered to be a factor in choosing elective AVR?. ### Response: patient age, avoidance of patient–prosthesis mismatch, anticoagulation issues, and patient preferences.


Instruction: What is the rate of symptom onset at 2 years?

Output: 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the rate of symptom onset at 2 years?. ### Response: 50%.


Instruction: What was associated with a >6-fold increased risk of aortic velocity 5 m/s?

Output: cardio-vascular mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with a >6-fold increased risk of aortic velocity 5 m/s?. ### Response: cardio-vascular mortality.


Instruction: What was associated with a >6-fold increased risk of cardio-vascular mortality?

Output: an aortic velocity ≥5 m/s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with a >6-fold increased risk of cardio-vascular mortality?. ### Response: an aortic velocity ≥5 m/s.


Instruction: What was the HR of a randomized trial of SAVR ver -sus continued surveillance?

Output: 6.31

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the HR of a randomized trial of SAVR ver -sus continued surveillance?. ### Response: 6.31.


Instruction: In patients with what velocity was there a significant survival benefit to early surgery?

Output: ≥4.5 m/s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with what velocity was there a significant survival benefit to early surgery?. ### Response: ≥4.5 m/s.


Instruction: What is a marker of sub-clinical HF?

Output: An elevated serum BNP level

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a marker of sub-clinical HF?. ### Response: An elevated serum BNP level.


Instruction: What is an aortic velocity of 4.5 m/s?

Output: ≥5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an aortic velocity of 4.5 m/s?. ### Response: ≥5.


Instruction: In patients with very severe AS and low surgical risk, what factors are taken into account?

Output: patient age, avoidance of patient–prosthesis mismatch, anticoagulation issues, and patient preferences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with very severe AS and low surgical risk, what factors are taken into account?. ### Response: patient age, avoidance of patient–prosthesis mismatch, anticoagulation issues, and patient preferences.


Instruction: What is a marker of sub-clinical HF and LV decompensation?

Output: An elevated serum BNP level

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a marker of sub-clinical HF and LV decompensation?. ### Response: An elevated serum BNP level.


Instruction: How many asymptomatic adults with severe AS had BNP levels associated with an increased 5-year risk of AS-related events?

Output: 387

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many asymptomatic adults with severe AS had BNP levels associated with an increased 5-year risk of AS-related events?. ### Response: 387.


Instruction: What should be conducted for early identification of CIED-related infectious complications?

Output: thorough patient education

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be conducted for early identification of CIED-related infectious complications?. ### Response: thorough patient education.


Instruction: There are no data to support the administration of what?

Output: prophylactic antibiotics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There are no data to support the administration of what?. ### Response: prophylactic antibiotics.


Instruction: Why is postoperative antibiotic therapy not recom-mend?

Output: the risk of drug adverse events,selection of drug-resistant organisms, and cost

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is postoperative antibiotic therapy not recom-mend?. ### Response: the risk of drug adverse events,selection of drug-resistant organisms, and cost.


Instruction: How long before incision should cefazolinis be given?

Output: 1 hour

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long before incision should cefazolinis be given?. ### Response: 1 hour.


Instruction: What antibiotic should be given intravenously within 2 hours of incision?

Output: vancomycin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What antibiotic should be given intravenously within 2 hours of incision?. ### Response: vancomycin.


Instruction: What should be given intravenously within 2 hours before incision?

Output: vancomycin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be given intravenously within 2 hours before incision?. ### Response: vancomycin.


Instruction: What do bacteria commonly gain entry to the circulation from?

Output: routine daily activities such as toothbrushing orfrom invasive procedures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do bacteria commonly gain entry to the circulation from?. ### Response: routine daily activities such as toothbrushing orfrom invasive procedures.


Instruction: What is secondary antibiotic prophylaxis used to prevent?

Output: hematog-enous infections

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is secondary antibiotic prophylaxis used to prevent?. ### Response: hematog-enous infections.


Instruction: Why are there few data to show efficacy?

Output: controversy surrounds this practice because there are few data toshow efficacy, and the risk from prophylaxis likely outweighsany benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why are there few data to show efficacy?. ### Response: controversy surrounds this practice because there are few data toshow efficacy, and the risk from prophylaxis likely outweighsany benefit.


Instruction: What is the risk from prophylactic antibiotics likely to outweigh?

Output: any benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk from prophylactic antibiotics likely to outweigh?. ### Response: any benefit.


Instruction: What does prophylaxis likely outweigh?

Output: any benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does prophylaxis likely outweigh?. ### Response: any benefit.


Instruction: What are concerns about the development of antibiotic-resistant bacterial pathogens?

Output: the possibility ofa fatal allergic reaction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are concerns about the development of antibiotic-resistant bacterial pathogens?. ### Response: the possibility ofa fatal allergic reaction.


Instruction: How long have the original recommendations been made?

Output: more than 50 years ago

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long have the original recommendations been made?. ### Response: more than 50 years ago.


Instruction: When were recommen-dations for antibiotics made?

Output: more than 50 years ago

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When were recommen-dations for antibiotics made?. ### Response: more than 50 years ago.


Instruction: What has been aproliferation of purported indications for the use of prophylactic antibiotics for?

Output: patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been aproliferation of purported indications for the use of prophylactic antibiotics for?. ### Response: patients.


Instruction: What is the scientific justification for administering antibioticprophylaxis for invasive procedures?

Output: little

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the scientific justification for administering antibioticprophylaxis for invasive procedures?. ### Response: little.


Instruction: A review of the literature from 1950 to 2007 for publications on cardiac electrophysiological deviceinfections reveals more than how many articles?

Output: 140

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A review of the literature from 1950 to 2007 for publications on cardiac electrophysiological deviceinfections reveals more than how many articles?. ### Response: 140.


Instruction: The predominance of what is staphylococci?

Output: pathogens

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The predominance of what is staphylococci?. ### Response: pathogens.


Instruction: Staphylococci are the most common pathogens in what type of infections?

Output: CIED

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Staphylococci are the most common pathogens in what type of infections?. ### Response: CIED.


Instruction: What type of prophylaxis for dental procedures is of little or no value?

Output: antibiotic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of prophylaxis for dental procedures is of little or no value?. ### Response: antibiotic.


Instruction: In the rare event of an oral pathogen infection, it is most likely to have arisen from what?

Output: abacteremia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the rare event of an oral pathogen infection, it is most likely to have arisen from what?. ### Response: abacteremia.


Instruction: What is most likely to have arisen from abacteremia?

Output: device infection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is most likely to have arisen from abacteremia?. ### Response: device infection.


Instruction: What is a common daily event such as toothbrushing?

Output: chewing food

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a common daily event such as toothbrushing?. ### Response: chewing food.


Instruction: There is currently no scientificbasis for the use of what?

Output: postoperative antibiotic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is currently no scientificbasis for the use of what?. ### Response: postoperative antibiotic therapy.


Instruction: What is PR?

Output: severe pulmonary regurgitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PR?. ### Response: severe pulmonary regurgitation.


Instruction: What is VT?

Output: ventricular tachycardia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is VT?. ### Response: ventricular tachycardia.


Instruction: To categorize disease severity in CHD in what patient?

Output: ACHD AP Classification

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: To categorize disease severity in CHD in what patient?. ### Response: ACHD AP Classification.


Instruction: What did the writing committee develop to categorize disease severity in CHD?

Output: ACHD Ana-tomic and Physiological (AP) classification system

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the writing committee develop to categorize disease severity in CHD?. ### Response: ACHD Ana-tomic and Physiological (AP) classification system.


Instruction: What are some of the variables that have prognostic value in patients with ACHD?

Output: physiological vari-ables

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the variables that have prognostic value in patients with ACHD?. ### Response: physiological vari-ables.


Instruction: What is the ACHD AP classification intended to capture?

Output: the com-plexity of ACHD anatomy and physiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ACHD AP classification intended to capture?. ### Response: the com-plexity of ACHD anatomy and physiology.


Instruction: What are not always correlated?

Output: ACHD anatomy and physiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are not always correlated?. ### Response: ACHD anatomy and physiology.


Instruction: What is shared across diagnoses?

Output: Certain anatomic abnormalities of clinical importance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is shared across diagnoses?. ### Response: Certain anatomic abnormalities of clinical importance.


Instruction: How are certain anatomic abnormalities of clinical importance found?

Output: shared across diagnoses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are certain anatomic abnormalities of clinical importance found?. ### Response: shared across diagnoses.


Instruction: What was more effective in reducing BP in the valsartan group?

Output: amlodipine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was more effective in reducing BP in the valsartan group?. ### Response: amlodipine.


Instruction: What was a strong trend for an excess risk of stroke?

Output: amlodipine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a strong trend for an excess risk of stroke?. ### Response: amlodipine.


Instruction: Which group had the same BP differential that favored amlodipine?

Output: valsartan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which group had the same BP differential that favored amlodipine?. ### Response: valsartan.


Instruction: What drug was favored by amlodipine?

Output: BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug was favored by amlodipine?. ### Response: BP.


Instruction: What was the goal of aggressive BP control in high-risk hypertensive patients?

Output: frequently requires combina-tion therapy at the outset

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the goal of aggressive BP control in high-risk hypertensive patients?. ### Response: frequently requires combina-tion therapy at the outset.


Instruction: Who supported the idea of combina-tion therapy at the outset?

Output: Blood Pressure Lowering Treatment Trialists’ Collaboration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who supported the idea of combina-tion therapy at the outset?. ### Response: Blood Pressure Lowering Treatment Trialists’ Collaboration.


Instruction: What should be prescribed to all CAD patients with stable angina who also have hypertension, diabetes mellitus, an LV ejection fraction 40% or CKD?

Output: Angiotensin Receptor BlockersARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be prescribed to all CAD patients with stable angina who also have hypertension, diabetes mellitus, an LV ejection fraction 40% or CKD?. ### Response: Angiotensin Receptor BlockersARBs.


Instruction: What did the HOPE study do?

Output: high-risk individuals, 80% of whom had CAD, were given an ACE inhibitor (ramipril 10 mg/d), with a reduction in CVD end points by 20% to 25%;

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the HOPE study do?. ### Response: high-risk individuals, 80% of whom had CAD, were given an ACE inhibitor (ramipril 10 mg/d), with a reduction in CVD end points by 20% to 25%;.


Instruction: What percentage of CAD patients were given an ACE inhibitor?

Output: 80%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of CAD patients were given an ACE inhibitor?. ### Response: 80%.


Instruction: What percentage of high-risk individuals had CAD?

Output: 80%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of high-risk individuals had CAD?. ### Response: 80%.


Instruction: What was the ACE inhibitor used for?

Output: management of patients with stable CAD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the ACE inhibitor used for?. ### Response: management of patients with stable CAD.


Instruction: How much was the reduction in CVD end points?

Output: 20% to 25%;

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much was the reduction in CVD end points?. ### Response: 20% to 25%;.


Instruction: EUROPA showed a 20% relative risk reduction in what end point?

Output: primary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: EUROPA showed a 20% relative risk reduction in what end point?. ### Response: primary.


Instruction: What is the dose of perindopril versus placebo?

Output: 8 mg/d

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the dose of perindopril versus placebo?. ### Response: 8 mg/d.


Instruction: What are some studies that have had negative results?

Output: PEACE,106

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some studies that have had negative results?. ### Response: PEACE,106.


Instruction: PEACE,106 showed what type of LV function in patients with stable CAD?

Output: normal or slightly reduced

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: PEACE,106 showed what type of LV function in patients with stable CAD?. ### Response: normal or slightly reduced.


Instruction: What is the target dose of trandolapril?

Output: 4 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the target dose of trandolapril?. ### Response: 4 mg.


Instruction: What was found to not be a difference between the groups in the incidence of the primary composite end point of cardiovascular death, MI, or coronary revascularization?

Output: Patients in the PEACE trial were at lower risk and were receiving more aggressive secondary prevention therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was found to not be a difference between the groups in the incidence of the primary composite end point of cardiovascular death, MI, or coronary revascularization?. ### Response: Patients in the PEACE trial were at lower risk and were receiving more aggressive secondary prevention therapy.


Instruction: Who was at lower risk for coronary revascularization in the PEACE trial?

Output: Patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was at lower risk for coronary revascularization in the PEACE trial?. ### Response: Patients.


Instruction: Who was receiving more aggressive secondary prevention therapy?

Output: Patients in the PEACE trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was receiving more aggressive secondary prevention therapy?. ### Response: Patients in the PEACE trial.


Instruction: What percent of participants in the ALLHAT trial had CAD?

Output: 25%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percent of participants in the ALLHAT trial had CAD?. ### Response: 25%.


Instruction: What was the primary outcome of the study?

Output: nonfa-tal MI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary outcome of the study?. ### Response: nonfa-tal MI.


Instruction: What is combined CAD plus coronary revascularization or hos-pitalization for angina?

Output: the primary outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is combined CAD plus coronary revascularization or hos-pitalization for angina?. ### Response: the primary outcome.


Instruction: What was the name of the study that reported the results of a prospective, open-label study in patients 65 to 84 years of age with hypertension?

Output: Second Australian National Blood Pressure Study (ANBP-2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the study that reported the results of a prospective, open-label study in patients 65 to 84 years of age with hypertension?. ### Response: Second Australian National Blood Pressure Study (ANBP-2.


Instruction: What did the study show in men but not in women?

Output: better cardiovascular outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the study show in men but not in women?. ### Response: better cardiovascular outcomes.


Instruction: What is better for women with ACE inhibitors than with diuretic agents?

Output: cardiovascular outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is better for women with ACE inhibitors than with diuretic agents?. ### Response: cardiovascular outcomes.


Instruction: What are Angiotensin Receptor Blockers recommended for all patients with stable angina?

Output: ARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are Angiotensin Receptor Blockers recommended for all patients with stable angina?. ### Response: ARBs.


Instruction: Who wrote the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al.


Instruction: What is the name of the content reviewer?

Output: Jacqueline E. Tamis-Holland

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the content reviewer?. ### Response: Jacqueline E. Tamis-Holland.


Instruction: Who is the Content Reviewer—Joint Committee on Clinical Practice Guidelines?

Output: Bulent Gorenek

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Content Reviewer—Joint Committee on Clinical Practice Guidelines?. ### Response: Bulent Gorenek.


Instruction: Who is a content reviewer at ACC/AHA Mayo Clinic?

Output: Carole A. Warnes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a content reviewer at ACC/AHA Mayo Clinic?. ### Response: Carole A. Warnes.


Instruction: What is the name of the committee that reviews content at the Mayo clinic?

Output: Jacqueline E. Tamis-Holland

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the committee that reviews content at the Mayo clinic?. ### Response: Jacqueline E. Tamis-Holland.


Instruction: Who is a content reviewer at ACC/AHA?

Output: David E. Newby

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a content reviewer at ACC/AHA?. ### Response: David E. Newby.


Instruction: What is the name of the person who reviewed content for ACC and AHA at Northwestern Hospital?

Output: David H. Adams

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the person who reviewed content for ACC and AHA at Northwestern Hospital?. ### Response: David H. Adams.


Instruction: Who is a content reviewer for the Joint Committee on Clinical Practice Guidelines?

Output: Jacqueline E. Tamis-Holland

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a content reviewer for the Joint Committee on Clinical Practice Guidelines?. ### Response: Jacqueline E. Tamis-Holland.


Instruction: What is the name of the professor of medicine at Duke Clinical Research Institute?

Output: Daniel B. Mark

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor of medicine at Duke Clinical Research Institute?. ### Response: Daniel B. Mark.


Instruction: Who is a Content Reviewer for the Joint Committee on Clinical Practice Guidelines?

Output: Jacqueline E. Tamis-Holland

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a Content Reviewer for the Joint Committee on Clinical Practice Guidelines?. ### Response: Jacqueline E. Tamis-Holland.


Instruction: What is the name of the organization that reviews clinical practice guidelines at Virginia Commonwealth University?

Output: School of Pharmacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that reviews clinical practice guidelines at Virginia Commonwealth University?. ### Response: School of Pharmacy.


Instruction: Who is a Content Reviewer at ACC/AHA Mt. Sinai Medical Center?

Output: David H. Adams

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a Content Reviewer at ACC/AHA Mt. Sinai Medical Center?. ### Response: David H. Adams.


Instruction: What is the title of the Newby Content Reviewer at the University of Edinburgh?

Output: Professor of Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of the Newby Content Reviewer at the University of Edinburgh?. ### Response: Professor of Cardiology.


Instruction: Who is the Professor of Cardiology at the Chancellor’s Building?

Output: AstraZeneca

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Professor of Cardiology at the Chancellor’s Building?. ### Response: AstraZeneca.


Instruction: Which company is affiliated with AstraZeneca?

Output: Bristol-Myers Squ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which company is affiliated with AstraZeneca?. ### Response: Bristol-Myers Squ.


Instruction: What company is associated with CellProthera?

Output: Bristol-Myers Squibb Company

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What company is associated with CellProthera?. ### Response: Bristol-Myers Squibb Company.


Instruction: What is a DSMB?

Output: UCB Inc

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a DSMB?. ### Response: UCB Inc.