Instruction: What policy determines what con-stitutes a relevant relationshi p?

Output: ACC RWI Policy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What policy determines what con-stitutes a relevant relationshi p?. ### Response: ACC RWI Policy.


Instruction: What must be chaired or co-chaired by an individual with no relevant RWI?

Output: ECDP writing groups

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must be chaired or co-chaired by an individual with no relevant RWI?. ### Response: ECDP writing groups.


Instruction: Who must constitute 50% of the writing group?

Output: external reviewers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who must constitute 50% of the writing group?. ### Response: external reviewers.


Instruction: 50% of the writing group?

Output: 40%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: 50% of the writing group?. ### Response: 40%,.


Instruction: Relevant disclosures for writing group, external reviewers, andSSOC members can be found in what?

Output: Appendixes 1 and 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Relevant disclosures for writing group, external reviewers, andSSOC members can be found in what?. ### Response: Appendixes 1 and 2.


Instruction: A full list of disclosure in-formation, including relationships not pertinent to this document, is available in Supplemental Appendix 1.

Output: T oensure complete transparency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A full list of disclosure in-formation, including relationships not pertinent to this document, is available in Supplemental Appendix 1.. ### Response: T oensure complete transparency.


Instruction: What is discouraged from acquiring relevant RWIthroughout the writing process?

Output: Participants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is discouraged from acquiring relevant RWIthroughout the writing process?. ### Response: Participants.


Instruction: What was considered by the writing group in development of the ECDP?

Output: speci ﬁca s -sumptions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was considered by the writing group in development of the ECDP?. ### Response: speci ﬁca s -sumptions.


Instruction: What is the focus of the ECDP?

Output: patients with HFrEF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the focus of the ECDP?. ### Response: patients with HFrEF.


Instruction: What are some of the recommendations relevant to?

Output: clinical decision-making

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the recommendations relevant to?. ### Response: clinical decision-making.


Instruction: What is the LVEF of patients with chronic ambulatory HFrEF?

Output: #40%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the LVEF of patients with chronic ambulatory HFrEF?. ### Response: #40%..


Instruction: The expert consensus writing committee endorses the evidence-based approaches to what?

Output: HF therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The expert consensus writing committee endorses the evidence-based approaches to what?. ### Response: HF therapy.


Instruction: In what year was HF therapy and man-agement enumerated in the ACC/AHA HF guideline?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was HF therapy and man-agement enumerated in the ACC/AHA HF guideline?. ### Response: 2013.


Instruction: What year were the 2016 and 2017 updates?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year were the 2016 and 2017 updates?. ### Response: 2013.


Instruction: In addition to a pharmacist, cardiologist, and an HFspecialist, what other relevant medical professional would a clinician seek input?

Output: diseas e management program

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In addition to a pharmacist, cardiologist, and an HFspecialist, what other relevant medical professional would a clinician seek input?. ### Response: diseas e management program.


Instruction: What should patient preferences and values be part-nership with?

Output: evidence-base d clinical judgment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patient preferences and values be part-nership with?. ### Response: evidence-base d clinical judgment.


Instruction: What should guide clinical decision-making?

Output: patient preferences and values

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should guide clinical decision-making?. ### Response: patient preferences and values.


Instruction: What is a yb es u p e r s e?

Output: db

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a yb es u p e r s e?. ### Response: db.


Instruction: What are the stages of HF?

Output: nStage A: At high risk for HF but without structural heartdisease or symptoms of HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the stages of HF?. ### Response: nStage A: At high risk for HF but without structural heartdisease or symptoms of HF.


Instruction: At high risk for HF but without structural heart disease or symptoms?

Output: nStage A

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: At high risk for HF but without structural heart disease or symptoms?. ### Response: nStage A.


Instruction: What is the stage B of HF without signs or symptoms?

Output: Structural heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the stage B of HF without signs or symptoms?. ### Response: Structural heart disease.


Instruction: What type of heart disease is stage C of?

Output: Structural heart di sease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of heart disease is stage C of?. ### Response: Structural heart di sease.


Instruction: How is HF diagnosed?

Output: HFrEF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is HF diagnosed?. ### Response: HFrEF.


Instruction: What is CHEST / 141/ 2/ FEBRUARY, 2012 SUPPLEMENT e37S 31?

Output: chestpubs.org

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CHEST / 141/ 2/ FEBRUARY, 2012 SUPPLEMENT e37S 31?. ### Response: chestpubs.org.


Instruction: Shaughnessy SG, Young E, Deschamps P, Hirsh J.

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Shaughnessy SG, Young E, Deschamps P, Hirsh J.. ### Response: 2012.


Instruction: Low molecular weight and standard heparin on cal-cium loss from fetal rat calvaria?

Output: xed-dose weight-adjusted unfractionated heparin and low-molecular-weight heparin for acute treatment of venous thromboembolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Low molecular weight and standard heparin on cal-cium loss from fetal rat calvaria?. ### Response: xed-dose weight-adjusted unfractionated heparin and low-molecular-weight heparin for acute treatment of venous thromboembolism.


Instruction: Blood. 1995 ; 86 ( 4 ): 1368 - 1373.

Output: Blood

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Blood. 1995 ; 86 ( 4 ): 1368 - 1373.. ### Response: Blood.


Instruction: Linkins L-A, Dans AL, Moores LK, et al.

Output: 32

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Linkins L-A, Dans AL, Moores LK, et al.. ### Response: 32.


Instruction: What is heparin-induced thrombocytopenia treated with?

Output: antithrom-botic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is heparin-induced thrombocytopenia treated with?. ### Response: antithrom-botic therapy.


Instruction: What is the 9th ed of the American College of Chest Physicians evidence-based clinical practice guidelines?

Output: Treatment and pre-vention of heparin-induced thrombocytopenia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 9th ed of the American College of Chest Physicians evidence-based clinical practice guidelines?. ### Response: Treatment and pre-vention of heparin-induced thrombocytopenia.


Instruction: What was Berkowitz SD's title?

Output: Orthopedics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was Berkowitz SD's title?. ### Response: Orthopedics.


Instruction: What is the name of the armamentarium used for deep vein thrombosis?

Output: therapeutic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the armamentarium used for deep vein thrombosis?. ### Response: therapeutic.


Instruction: When was Orthopedics published?

Output: 1995

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Orthopedics published?. ### Response: 1995.


Instruction: Subcutaneous vs intravenous heparin in the treatment of deep vein thrombosis—a randomized clinical trial?

Output: intra-venous and subcutaneous administration .   Thromb Res  .   1985 ; 39 ( 5 ): 631 - 636 .      37 .  Powers   PJ ,  Gent   M ,  Jay   RM ,  et al .  A randomized trial of less intense postoperative warfarin or aspirin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Subcutaneous vs intravenous heparin in the treatment of deep vein thrombosis—a randomized clinical trial?. ### Response: intra-venous and subcutaneous administration .   Thromb Res  .   1985 ; 39 ( 5 ): 631 - 636 .      37 .  Powers   PJ ,  Gent   M ,  Jay   RM ,  et al .  A randomized trial of less intense postoperative warfarin or aspirin therapy.


Instruction: Deep venous thrombosis—a randomized clinical trial?

Output: Subcutaneous vs intravenous heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Deep venous thrombosis—a randomized clinical trial?. ### Response: Subcutaneous vs intravenous heparin.


Instruction: How many ( 2 ): 222 - 226 were in Thromb Haemost in 1990?

Output: 64

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many ( 2 ): 222 - 226 were in Thromb Haemost in 1990?. ### Response: 64.


Instruction: What is Fixed-Dose Heparin?

Output: FIDO

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Fixed-Dose Heparin?. ### Response: FIDO.


Instruction: What is the difference between fi xed-dose and low-molecular-weight heparin for acute treatment of venous thromboembolism?

Output: weight-adjusted unfractionated heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between fi xed-dose and low-molecular-weight heparin for acute treatment of venous thromboembolism?. ### Response: weight-adjusted unfractionated heparin.


Instruction: When did JAMA issue 296?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did JAMA issue 296?. ### Response: 2006.


Instruction: What year was JAMA published?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was JAMA published?. ### Response: 2006.


Instruction: How many pages were in JAMA in 2006?

Output: 296 ( 8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many pages were in JAMA in 2006?. ### Response: 296 ( 8.


Instruction: What is the molecular weight of heparin?

Output: PK 10 169

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the molecular weight of heparin?. ### Response: PK 10 169.


Instruction: What are the PK 10 169 and unfractionated?

Output: heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the PK 10 169 and unfractionated?. ### Response: heparin.


Instruction: When was Thromb Res published?

Output: 1985

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Thromb Res published?. ### Response: 1985.


Instruction: What is the name of the randomized trial of less intense postoperative warfarin?

Output: aspirin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized trial of less intense postoperative warfarin?. ### Response: aspirin therapy.


Instruction: What was a randomized trial of less intense postoperative warfarin or aspirin therapy in the prevention of after surgery for fractured hip?

Output: venous thromboembolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a randomized trial of less intense postoperative warfarin or aspirin therapy in the prevention of after surgery for fractured hip?. ### Response: venous thromboembolism.


Instruction: What was the name of the randomized study?

Output: Thromb Haemost

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the randomized study?. ### Response: Thromb Haemost.


Instruction: When was the 149 ( 4 ): 771- 774 published?

Output: 1989

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the 149 ( 4 ): 771- 774 published?. ### Response: 1989.


Instruction: How many. 38?

Output: 379

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many. 38?. ### Response: 379.


Instruction: What is heparin kinetics in?

Output: venous thrombosis and pul-monary embolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is heparin kinetics in?. ### Response: venous thrombosis and pul-monary embolism.


Instruction: Who is Yung WL?

Output: Heparin kinetics in venous thrombosis and pul-monary embolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Yung WL?. ### Response: Heparin kinetics in venous thrombosis and pul-monary embolism.


Instruction: What is heparin kinetics in in venous thrombosis and pulmonary embolism?

Output: weight-adjusted unfractionated heparin and low-molecular-weight

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is heparin kinetics in in venous thrombosis and pulmonary embolism?. ### Response: weight-adjusted unfractionated heparin and low-molecular-weight.


Instruction: What is Brey RL's specialty?

Output: Antiphospholipid antibodies and ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Brey RL's specialty?. ### Response: Antiphospholipid antibodies and ischemic stroke.


Instruction: Antiphospholipid antibodies and ischemic stroke. 1992 ; 1 ( 6 ): 379 - 382.

Output: Heart Dis Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Antiphospholipid antibodies and ischemic stroke. 1992 ; 1 ( 6 ): 379 - 382.. ### Response: Heart Dis Stroke.


Instruction: Bârzu T, Molho P, et al.

Output: 40

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Bârzu T, Molho P, et al.. ### Response: 40.


Instruction: What is binding and endocytosis of heparin by human endothelial cells in culture?

Output: Kinetics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is binding and endocytosis of heparin by human endothelial cells in culture?. ### Response: Kinetics.


Instruction: What year was Biochim Biophys Acta published?

Output: 1985

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was Biochim Biophys Acta published?. ### Response: 1985.


Instruction: How many ( 2 ): 196 - 203?

Output: 845

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many ( 2 ): 196 - 203?. ### Response: 845.


Instruction: Who inhibited von Willebrand factor-dependent platelet function in vitro and in vivo?

Output: Heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who inhibited von Willebrand factor-dependent platelet function in vitro and in vivo?. ### Response: Heparin.


Instruction: When did J Clin Invest publish 87 ( 5 ): 1787 - 1793?

Output: 1991

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J Clin Invest publish 87 ( 5 ): 1787 - 1793?. ### Response: 1991.


Instruction: How many assay methods did Bjornsson TD, Wolfram KM, Kitchell BB use to determine heparin kinetics?

Output: three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many assay methods did Bjornsson TD, Wolfram KM, Kitchell BB use to determine heparin kinetics?. ### Response: three.


Instruction: What year did Clin Pharmacol Ther issue 31 ( 1 ): 104?

Output: 1982

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Clin Pharmacol Ther issue 31 ( 1 ): 104?. ### Response: 1982.


Instruction: What was the average number of intravenously administered antibiotics in 1982?

Output: 104 - 113

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the average number of intravenously administered antibiotics in 1982?. ### Response: 104 - 113.


Instruction: What is the average amount of intravenous antibiotics used in 1982 in the United States?

Output: 1251 - 1258

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the average amount of intravenous antibiotics used in 1982 in the United States?. ### Response: 1251 - 1258.


Instruction: In 1982, what percentage of the population was given antibiotics?

Output: 104 - 113

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In 1982, what percentage of the population was given antibiotics?. ### Response: 104 - 113.


Instruction: What is the name of the drug that is administered intravenously in humans?

Output: heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug that is administered intravenously in humans?. ### Response: heparin.


Instruction: How many blood samples were collected in 1982?

Output: 1251 - 1258

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many blood samples were collected in 1982?. ### Response: 1251 - 1258.


Instruction: What was the total number of blood samples collected from 1982-82?

Output: 1251 - 1258

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the total number of blood samples collected from 1982-82?. ### Response: 1251 - 1258.


Instruction: What is the 2014 AHA/ACC NSTE-ACS Guideline e397?

Output: electrocardiographic findings undergoing evaluation for coronary artery disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2014 AHA/ACC NSTE-ACS Guideline e397?. ### Response: electrocardiographic findings undergoing evaluation for coronary artery disease.


Instruction: What are electrocardiographic findings undergoing evaluation for?

Output: coronary artery disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are electrocardiographic findings undergoing evaluation for?. ### Response: coronary artery disease.


Instruction: When did Mayo Clin Proc. 2002:77:515–21?

Output: 105

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Mayo Clin Proc. 2002:77:515–21?. ### Response: 105.


Instruction: What year did the American College of Cardiology/American Heart Association Task Force on Practice Guidelines Writing Group develop the 2007 chronic angina focused update of the ACC/AHA 2002 guidelines?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did the American College of Cardiology/American Heart Association Task Force on Practice Guidelines Writing Group develop the 2007 chronic angina focused update of the ACC/AHA 2002 guidelines?. ### Response: 2007.


Instruction: What did the Task Force on Practice Guidelines Writing Group develop?

Output: the focused update of the 2002 guidelines for the management of patients with chronic stable angina

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Task Force on Practice Guidelines Writing Group develop?. ### Response: the focused update of the 2002 guidelines for the management of patients with chronic stable angina.


Instruction: What was the focus of the update of the 2002 guidelines for the management of patients with chronic stable angina?

Output: American College of Cardiology/American Heart Association Task Force on Practice Guidelines Writing Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the focus of the update of the 2002 guidelines for the management of patients with chronic stable angina?. ### Response: American College of Cardiology/American Heart Association Task Force on Practice Guidelines Writing Group.


Instruction: Circulation 2007;116:2762–72.

Output: 107

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation 2007;116:2762–72.. ### Response: 107.


Instruction: What does sex make a difference in acute coronary syndromes?

Output: Symptoms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does sex make a difference in acute coronary syndromes?. ### Response: Symptoms.


Instruction: What is the name of the study that examined women's early warning symptoms of acute myocardial infarction?

Output: MERLIN-TIMI 36

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined women's early warning symptoms of acute myocardial infarction?. ### Response: MERLIN-TIMI 36.


Instruction: When was the N Engl J Med published?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the N Engl J Med published?. ### Response: 2005.


Instruction: What are women's early warning symptoms of?

Output: acute myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are women's early warning symptoms of?. ### Response: acute myocardial infarction.


Instruction: What is Circulation. 2003?

Output: 108:2619–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Circulation. 2003?. ### Response: 108:2619–.


Instruction: Who is Lee TH, Cook EF, Weisberg M, et al?

Output: 110

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Lee TH, Cook EF, Weisberg M, et al?. ### Response: 110.


Instruction: What is a predictive instrument to improve coronary care unit admission practices in acute ischemic heart dis-ease?

Output: A prospective multicenter clinical trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a predictive instrument to improve coronary care unit admission practices in acute ischemic heart dis-ease?. ### Response: A prospective multicenter clinical trial.


Instruction: A prospective multicenter clinical trial. 1984;310:1273–8. 12. Selker HP, Griffith JL, D'Agostino RB. What is the tool valid for?

Output: real-time and retrospec-tive use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A prospective multicenter clinical trial. 1984;310:1273–8. 12. Selker HP, Griffith JL, D'Agostino RB. What is the tool valid for?. ### Response: real-time and retrospec-tive use.


Instruction: What is a time-insensitive predictive instrument?

Output: TIPI) for acute cardiac ischemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a time-insensitive predictive instrument?. ### Response: TIPI) for acute cardiac ischemia.


Instruction: What does TIPI stand for?

Output: time-insensitive predictive instrument

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does TIPI stand for?. ### Response: time-insensitive predictive instrument.


Instruction: What does not predict active coronary artery disease?

Output: Chest pain relief by nitro-glycerin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not predict active coronary artery disease?. ### Response: Chest pain relief by nitro-glycerin.


Instruction: What does nitro-glycerin not predict?

Output: active coronary artery disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does nitro-glycerin not predict?. ### Response: active coronary artery disease.


Instruction: When did Ann Intern Med issue 139: 979-86?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Ann Intern Med issue 139: 979-86?. ### Response: 2003.


Instruction: Who is Swap CJ, Nagurney JT?

Output: 114

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Swap CJ, Nagurney JT?. ### Response: 114.


Instruction: What is the GUSTO-I trial?

Output: Global Utilization of Streptokinase and TPA for occluded arteries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the GUSTO-I trial?. ### Response: Global Utilization of Streptokinase and TPA for occluded arteries.


Instruction: What are the benefits of early sustained reperfusion in patients with prior myocardial infarction?

Output: Global Utilization of Streptokinase and TPA for occluded arteries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the benefits of early sustained reperfusion in patients with prior myocardial infarction?. ### Response: Global Utilization of Streptokinase and TPA for occluded arteries.


Instruction: Global Utilization of Streptokinase and TPA for occluded arteries.

Output: -I trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Global Utilization of Streptokinase and TPA for occluded arteries.. ### Response: -I trial.


Instruction: What is MERLIN-TIMI 36?

Output: non-ST-elevation acute coronary syndromes-thrombolysis in myocardial infarction 36

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is MERLIN-TIMI 36?. ### Response: non-ST-elevation acute coronary syndromes-thrombolysis in myocardial infarction 36.


Instruction: What is the name of the metabolic efficiency study of women with unstable ischemic heart disease?

Output: meta-bolic efficiency with ranolazine for less ischemia in non-ST-elevation acute coronary syndromes-thrombolysis in myocardial infarction 36 (MERLIN-TIMI 36

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the metabolic efficiency study of women with unstable ischemic heart disease?. ### Response: meta-bolic efficiency with ranolazine for less ischemia in non-ST-elevation acute coronary syndromes-thrombolysis in myocardial infarction 36 (MERLIN-TIMI 36.


Instruction: When was Circulation. 2010;121:1809-17?

Output: 2010;121:1809–17. 117. Holmes DR Jr., White HD, Pieper KS, et al. Effect of age on outcome with primary angioplasty versus thrombolysis. J Am Coll Cardiol. 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Circulation. 2010;121:1809-17?. ### Response: 2010;121:1809–17. 117. Holmes DR Jr., White HD, Pieper KS, et al. Effect of age on outcome with primary angioplasty versus thrombolysis. J Am Coll Cardiol. 1999.


Instruction: What is the effect of age on outcome with primary angioplasty versus thrombolysis?

Output: Comparative effects of aging and coronary heart dis-ease on submaximal and maximal exercise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of age on outcome with primary angioplasty versus thrombolysis?. ### Response: Comparative effects of aging and coronary heart dis-ease on submaximal and maximal exercise.


Instruction: J Am Coll Cardiol. 1999;33:412–9.

Output: early sustained reper

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: J Am Coll Cardiol. 1999;33:412–9.. ### Response: early sustained reper.


Instruction: What year did NICE publish Chronic Heart Failure Monitoring?

Output: 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did NICE publish Chronic Heart Failure Monitoring?. ### Response: 2018.


Instruction: Who is subject to notice of rights?

Output: Chronic Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is subject to notice of rights?. ### Response: Chronic Heart Failure.


Instruction: What is the ISBN number of the PICO characteristic?

Output: 978 -1-4731 -3093 -7 260

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ISBN number of the PICO characteristic?. ### Response: 978 -1-4731 -3093 -7 260.


Instruction: What is the term for circulating biomarker concentration measured in a community or outpatient setting?

Output: Biomarker monitoring: serial (protocol -driven

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for circulating biomarker concentration measured in a community or outpatient setting?. ### Response: Biomarker monitoring: serial (protocol -driven.


Instruction: What is another term for Troponin?

Output: alone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for Troponin?. ### Response: alone.


Instruction: What is BNP?

Output: repeated biomarker  measurement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is BNP?. ### Response: repeated biomarker  measurement.


Instruction: What is Troponin?

Output: alone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Troponin?. ### Response: alone.


Instruction: How many biomarkers are combined?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many biomarkers are combined?. ### Response: 3.


Instruction: Cardiovascular MRI Imaging monitoring: serial (protocol -driven) What is echocardiography?

Output: repeated cardiac  imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cardiovascular MRI Imaging monitoring: serial (protocol -driven) What is echocardiography?. ### Response: repeated cardiac  imaging.


Instruction: What are the Outcomes CRITICAL?

Output: Mortality (Time to event)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Outcomes CRITICAL?. ### Response: Mortality (Time to event).


Instruction: What is the Time to event?

Output: Mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Time to event?. ### Response: Mortality.


Instruction: How long is the Quality of Life at 12 months?

Output: Continuous

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the Quality of Life at 12 months?. ### Response: Continuous.


Instruction: What is the term for unplanned hospitalisation?

Output: all -cause

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for unplanned hospitalisation?. ### Response: all -cause.


Instruction: What is another term for hypotension?

Output: Dichotomous

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for hypotension?. ### Response: Dichotomous.


Instruction: Adverse events - hyperkalaemia are what?

Output: Dichotomous

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Adverse events - hyperkalaemia are what?. ### Response: Dichotomous.


Instruction: What is bradycardia?

Output: Dichotomous

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is bradycardia?. ### Response: Dichotomous.


Instruction: What is dysrhythmic events?

Output: Adverse events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is dysrhythmic events?. ### Response: Adverse events.


Instruction: How were systematic reviews of RCTs conducted?

Output: comparing the effectiveness of monitoring with repeated biomarker  measurement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How were systematic reviews of RCTs conducted?. ### Response: comparing the effectiveness of monitoring with repeated biomarker  measurement.


Instruction: Randomised trials comparing the effectiveness of monitoring with repeated biomarker measurement or repeated cardiac imaging were compared to usual care without repeated measurement or imaging?

Output: that had a population or subgroup with chronic kidney disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Randomised trials comparing the effectiveness of monitoring with repeated biomarker measurement or repeated cardiac imaging were compared to usual care without repeated measurement or imaging?. ### Response: that had a population or subgroup with chronic kidney disease.


Instruction: What was the population or subgroup with chronic kidney disease in randomised trials?

Output: People diagnosed with heart failure in a community or outpatient setting who also have chronic kidney disease   Aged under 75 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the population or subgroup with chronic kidney disease in randomised trials?. ### Response: People diagnosed with heart failure in a community or outpatient setting who also have chronic kidney disease   Aged under 75 years.


Instruction: How many studies were included in the systematic review?

Output: 55, 338

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were included in the systematic review?. ### Response: 55, 338.


Instruction: What are the summaries of the analyses?

Output: Table 85 and Table 86

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the summaries of the analyses?. ### Response: Table 85 and Table 86.


Instruction: What are the summarised in Table 85 and Table 86?

Output: Subgroup analyses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the summarised in Table 85 and Table 86?. ### Response: Subgroup analyses.


Instruction: Where is the clinical evidence summarized?

Output: Table 87

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the clinical evidence summarized?. ### Response: Table 87.


Instruction: What is the study selection flow chart in Appendix C?

Output: See also the study selection flow chart in Appendix  C, forest plots in Appendix  E, study evidence tables in Appendix  F, GRADE tables in Appendix  H and excluded studies list in Appendix  I

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the study selection flow chart in Appendix C?. ### Response: See also the study selection flow chart in Appendix  C, forest plots in Appendix  E, study evidence tables in Appendix  F, GRADE tables in Appendix  H and excluded studies list in Appendix  I.


Instruction: Where are GRADE tables located?

Output: Appendix  H

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are GRADE tables located?. ### Response: Appendix  H.


Instruction: Where are excluded studies listed?

Output: Appendix  I

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are excluded studies listed?. ### Response: Appendix  I.


Instruction: What is in Appendix I?

Output: excluded studies list

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is in Appendix I?. ### Response: excluded studies list.


Instruction: Where can you find out what NICE has said on r elated topics?

Output: NICE w ebpage on car diovascular conditions .

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find out what NICE has said on r elated topics?. ### Response: NICE w ebpage on car diovascular conditions ..


Instruction: What is NICE Pat hway on?

Output: chr onic hear t failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE Pat hway on?. ### Response: chr onic hear t failure.


Instruction: What is the NICE w ebpage on car diovascular conditions?

Output: To find out what NICE has said on r elated topics, including guidance in de velopment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the NICE w ebpage on car diovascular conditions?. ### Response: To find out what NICE has said on r elated topics, including guidance in de velopment.


Instruction: For full details of t he evidence and guideline committee's discussions, see the full guideline?

Output: resour ces t o help y ou put NICE guidance int o practice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For full details of t he evidence and guideline committee's discussions, see the full guideline?. ### Response: resour ces t o help y ou put NICE guidance int o practice.


Instruction: How was the guideline developed?

Output: de veloped

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the guideline developed?. ### Response: de veloped.


Instruction: NICE has pr oduced what to help y ou put his guideline int o practice?

Output: tools

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: NICE has pr oduced what to help y ou put his guideline int o practice?. ### Response: tools.


Instruction: What is NG106?

Output: Chronic hear t failure in adult s: diagnosis and management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NG106?. ### Response: Chronic hear t failure in adult s: diagnosis and management.


Instruction: What is NICE 2023?

Output: Chronic hear t failure in adult s: diagnosis and management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE 2023?. ### Response: Chronic hear t failure in adult s: diagnosis and management.


Instruction: Management (NG106) NICE 2023. All rights s reserved.

Output: Chronic hear t failure in adult s: diagnosis and management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Management (NG106) NICE 2023. All rights s reserved.. ### Response: Chronic hear t failure in adult s: diagnosis and management.


Instruction: Subject t o Notice of right s.

Output: https://www .nice.or g.uk/t erms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Subject t o Notice of right s.. ### Response: https://www .nice.or g.uk/t erms.


Instruction: What is a key feature of many chronic rheumatologic inflam-matory joint disorders?

Output: systemic lupus ery-thematosus, RA, and psoriasis.S4.5.5-1 Inflammation mediates the progression of atherosclerosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a key feature of many chronic rheumatologic inflam-matory joint disorders?. ### Response: systemic lupus ery-thematosus, RA, and psoriasis.S4.5.5-1 Inflammation mediates the progression of atherosclerosis.


Instruction: Inflammation mediates the progression of what?

Output: atherosclerosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Inflammation mediates the progression of what?. ### Response: atherosclerosis.


Instruction: What is the risk of MI among individu-als with RA?

Output: similar to that of an adult with diabetes mel-litus or one who is about 10 years older without RA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of MI among individu-als with RA?. ### Response: similar to that of an adult with diabetes mel-litus or one who is about 10 years older without RA.


Instruction: What is the risk of CVD death for people with RA?

Output: 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of CVD death for people with RA?. ### Response: 50%.


Instruction: What type of lupus erythematosus have a 50% increased risk of death?

Output: systemic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of lupus erythematosus have a 50% increased risk of death?. ### Response: systemic.


Instruction: What is an increased risk of in people with systemic lupus erythematosus and advanced psoriasis?

Output: CVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an increased risk of in people with systemic lupus erythematosus and advanced psoriasis?. ### Response: CVD.


Instruction: What is HIV infection associated with?

Output: an increased risk of an ASCVD event

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is HIV infection associated with?. ### Response: an increased risk of an ASCVD event.


Instruction: What is an increased risk of MI in association with long-term use of antiretroviral therapy?

Output: S4.5.5-8 There is an increased risk of MI in association with long-term use of antiretroviral therapy, and MI rates are increased in individuals with HIV

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an increased risk of MI in association with long-term use of antiretroviral therapy?. ### Response: S4.5.5-8 There is an increased risk of MI in association with long-term use of antiretroviral therapy, and MI rates are increased in individuals with HIV.


Instruction: MI rates are increased in individuals with what?

Output: HIV

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: MI rates are increased in individuals with what?. ### Response: HIV.


Instruction: What are mediators of atheroscle-rosis progression and development?

Output: Inflammation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are mediators of atheroscle-rosis progression and development?. ### Response: Inflammation.


Instruction: What is often present in HIV-infected individuals and further increases ASCVD risk?

Output: Coinfection with hepatitis C virus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is often present in HIV-infected individuals and further increases ASCVD risk?. ### Response: Coinfection with hepatitis C virus.


Instruction: What has not been well validated for adults with chronic inflam-matory disorders or HIV infection?

Output: The accuracy of the ASCVD risk estimator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has not been well validated for adults with chronic inflam-matory disorders or HIV infection?. ### Response: The accuracy of the ASCVD risk estimator.


Instruction: What has often resulted in underestimation of actual risk and the potential for undertreat-ment with pharmacological therapy?

Output: Assessment of traditional risk factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has often resulted in underestimation of actual risk and the potential for undertreat-ment with pharmacological therapy?. ### Response: Assessment of traditional risk factors.


Instruction: Traditional risk factors should be assessed early in the disease process and then what?

Output: modified

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Traditional risk factors should be assessed early in the disease process and then what?. ### Response: modified.


Instruction: Rates of smok-ing in HIV-infected adults have generally been how many times?

Output: 2 to 3 times

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Rates of smok-ing in HIV-infected adults have generally been how many times?. ### Response: 2 to 3 times.


Instruction: How many times have HIV-infected adults been compared to the general population?

Output: 2 to 3 times

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many times have HIV-infected adults been compared to the general population?. ### Response: 2 to 3 times.


Instruction: Multiple studies have demonstrated underestimation of ASCVD risk in patients with chronic inflam-matory conditions or HIV?

Output: S4.5.5-15,S4.5.5-16

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Multiple studies have demonstrated underestimation of ASCVD risk in patients with chronic inflam-matory conditions or HIV?. ### Response: S4.5.5-15,S4.5.5-16.


Instruction: Antiretroviral therapy may adversely affect what?

Output: lipid levels, glycemic control, and endothelial function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Antiretroviral therapy may adversely affect what?. ### Response: lipid levels, glycemic control, and endothelial function.


Instruction: What is the most common lipid abnormality phenotype in persons?

Output: elevated triglycer -ide level with a low HDL-C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common lipid abnormality phenotype in persons?. ### Response: elevated triglycer -ide level with a low HDL-C.


Instruction: What may the use of prednisone in chronic inflammatory diseases worsen?

Output: glycemic control and dyslipidemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may the use of prednisone in chronic inflammatory diseases worsen?. ### Response: glycemic control and dyslipidemia.


Instruction: What is the most common lipid abnormality phenotype in persons with HIV infection?

Output: elevated triglycer -ide level with a low HDL-C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common lipid abnormality phenotype in persons with HIV infection?. ### Response: elevated triglycer -ide level with a low HDL-C.


Instruction: What is an elevated triglycer -ide level with a low HDL-C?

Output: The most common lipid abnormality phenotype in persons with HIV infection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an elevated triglycer -ide level with a low HDL-C?. ### Response: The most common lipid abnormality phenotype in persons with HIV infection.


Instruction: What is the purpose of the Clinical Practice Guideline?

Output: to provide information and assist decision making

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of the Clinical Practice Guideline?. ### Response: to provide information and assist decision making.


Instruction: When was the last systematic literature search conducted?

Output: January 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last systematic literature search conducted?. ### Response: January 2011.


Instruction: What is not intended to define astandard of care?

Output: speciﬁc protocol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not intended to define astandard of care?. ### Response: speciﬁc protocol.


Instruction: What should not be interpreted as prescribingan exclusive course of management?

Output: speciﬁc protocol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not be interpreted as prescribingan exclusive course of management?. ### Response: speciﬁc protocol.


Instruction: Variations in practice will inevitably and appropriately occur when clinicians take into account the needs of individual patients, available resources, and what else?

Output: limitations unique to an institution or type of practice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Variations in practice will inevitably and appropriately occur when clinicians take into account the needs of individual patients, available resources, and what else?. ### Response: limitations unique to an institution or type of practice.


Instruction: What is the responsibility of every health-care professional making use of these recommendations?

Output: evaluating the appropriateness of applying themin any particular clinical situation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the responsibility of every health-care professional making use of these recommendations?. ### Response: evaluating the appropriateness of applying themin any particular clinical situation.


Instruction: What are the recommendations for research contained within this document?

Output: general

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the recommendations for research contained within this document?. ### Response: general.


Instruction: What does KDIGO stand for?

Output: Kidney Disease: Improving Global Outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does KDIGO stand for?. ### Response: Kidney Disease: Improving Global Outcomes.


Instruction: What is the purpose of the disclosure of the information in this document?

Output: to provide information and assist decision making

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of the disclosure of the information in this document?. ### Response: to provide information and assist decision making.


Instruction: What are members of the Work Group required to complete, sign, and submit a disclosure and attestation form?

Output: all such relationships that might be perceived or actual conﬂicts of interest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are members of the Work Group required to complete, sign, and submit a disclosure and attestation form?. ### Response: all such relationships that might be perceived or actual conﬂicts of interest.


Instruction: How often is this document updated?

Output: annually

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often is this document updated?. ### Response: annually.


Instruction: Where is all reported information published?

Output: Work Group members’ Biographicand Disclosure Information section

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is all reported information published?. ### Response: Work Group members’ Biographicand Disclosure Information section.


Instruction: Who is the Managing Agent for KDIGO?

Output: NationalKidney Foundation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Managing Agent for KDIGO?. ### Response: NationalKidney Foundation.


Instruction: What is the name of the Managing Agent for KDIGO?

Output: NationalKidney Foundation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Managing Agent for KDIGO?. ### Response: NationalKidney Foundation.


Instruction: What may be made for personal use as allowed by national copyright laws?

Output: Single photocopies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be made for personal use as allowed by national copyright laws?. ### Response: Single photocopies.


Instruction: What type of use may photocopies be used for?

Output: personal use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of use may photocopies be used for?. ### Response: personal use.


Instruction: What is required to obtain permission for reproduction or translation of this publication?

Output: explicit permission inwriting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is required to obtain permission for reproduction or translation of this publication?. ### Response: explicit permission inwriting.


Instruction: Who is KDIGO's Managing Director?

Output: Danielle Green

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is KDIGO's Managing Director?. ### Response: Danielle Green.


Instruction: What is the name of the person who is responsible for obtaining permission for reproduction or translation?

Output: Danielle Green

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the person who is responsible for obtaining permission for reproduction or translation?. ### Response: Danielle Green.


Instruction: Who is the Managing Agent?

Output: NationalKidney Foundation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Managing Agent?. ### Response: NationalKidney Foundation.


Instruction: What are the outcomes of ASCVD focused on?

Output: acute coronary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the outcomes of ASCVD focused on?. ### Response: acute coronary.


Instruction: When will the AHA Journals be available for download?

Output: May 1, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When will the AHA Journals be available for download?. ### Response: May 1, 2023.


Instruction: What is the term for proximal extracranial carotid occlusion?

Output: no revascularization of the proximal lesion versus angioplasty versus stenting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for proximal extracranial carotid occlusion?. ### Response: no revascularization of the proximal lesion versus angioplasty versus stenting.


Instruction: How many patients underwent mechanical thrombectomy?

Output: 395

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients underwent mechanical thrombectomy?. ### Response: 395.


Instruction: What was the name of the study that examined 395 patients with AIS?

Output: A retrospective analysis of pooled data from 18 centers examined 395 patients with AIS caused by tandem lesion of the anterior circulation who underwent mechanical thrombectomy (TITAN

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the study that examined 395 patients with AIS?. ### Response: A retrospective analysis of pooled data from 18 centers examined 395 patients with AIS caused by tandem lesion of the anterior circulation who underwent mechanical thrombectomy (TITAN.


Instruction: What is TITAN?

Output: Thrombectomy in Tandem Lesions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is TITAN?. ### Response: Thrombectomy in Tandem Lesions.


Instruction: What was achieved in 76.7% of patients?

Output: mTICI grade 2b/3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was achieved in 76.7% of patients?. ### Response: mTICI grade 2b/3.


Instruction: At 90 days, what percentage of patients achieved an mRS score of 0 to 2?

Output: 52.2%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: At 90 days, what percentage of patients achieved an mRS score of 0 to 2?. ### Response: 52.2%.


Instruction: What do multiple retrospective reports detail?

Output: technical success of mechanical thrombectomy for tandem occlusions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do multiple retrospective reports detail?. ### Response: technical success of mechanical thrombectomy for tandem occlusions.


Instruction: What do the reports do not provide specifics on?

Output: comparative approaches

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do the reports do not provide specifics on?. ### Response: comparative approaches.


Instruction: No conclusions about the optimum treatment approach for patients with tandem occlusions are therefore possible?

Output: Multiple retrospective reports detail the technical success of mechanical thrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No conclusions about the optimum treatment approach for patients with tandem occlusions are therefore possible?. ### Response: Multiple retrospective reports detail the technical success of mechanical thrombectomy.


Instruction: What is unknown about IV glycoprotein IIb/IIIa inhibitors administered during endovascular stroke treatment?

Output: The safety and efficacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is unknown about IV glycoprotein IIb/IIIa inhibitors administered during endovascular stroke treatment?. ### Response: The safety and efficacy.


Instruction: What is uncertain about the safety and efficacy of abciximab?

Output: safety and efficacy of IV glycoprotein IIb/IIIa inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is uncertain about the safety and efficacy of abciximab?. ### Response: safety and efficacy of IV glycoprotein IIb/IIIa inhibitors.


Instruction: What is the setting of endovascular stroke treatment limited to?

Output: case series and retrospective reviews of single-center databases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the setting of endovascular stroke treatment limited to?. ### Response: case series and retrospective reviews of single-center databases.


Instruction: What focuses primarily on administration of IV glycoprotein IIb/IIIa inhibitors to prevent thrombus formation?

Output: The published literature

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What focuses primarily on administration of IV glycoprotein IIb/IIIa inhibitors to prevent thrombus formation?. ### Response: The published literature.


Instruction: What is needed for emergent angioplasty and stenting?

Output: adjunctive antiplatelet therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed for emergent angioplasty and stenting?. ### Response: adjunctive antiplatelet therapy.


Instruction: What type of adjuncts may be reasonable to achieve mTICI grade 2b/3?

Output: salvage technical adjuncts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of adjuncts may be reasonable to achieve mTICI grade 2b/3?. ### Response: salvage technical adjuncts.


Instruction: What may be reasonable to achieve mTICI grade 2b/3 angiographic results?

Output: Use of salvage technical adjuncts, including intra-arterial fibrinolysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be reasonable to achieve mTICI grade 2b/3 angiographic results?. ### Response: Use of salvage technical adjuncts, including intra-arterial fibrinolysis.


Instruction: What was reworded for clarity from 2015 Endovascular?

Output: IIb C-LDRecommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was reworded for clarity from 2015 Endovascular?. ### Response: IIb C-LDRecommendation.


Instruction: What therapy played a limited role in the recent endovascular trials?

Output: Intra-arterial fibrinolytic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What therapy played a limited role in the recent endovascular trials?. ### Response: Intra-arterial fibrinolytic.


Instruction: What was used as rescue therapy, not initial treatment?

Output: Intra-arterial fibrinolytic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was used as rescue therapy, not initial treatment?. ### Response: Intra-arterial fibrinolytic therapy.


Instruction: How many of 233 patients were treated with alternative stent retrievers to Trevo and Solitaire or intra-arterial alteplase?

Output: 40

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many of 233 patients were treated with alternative stent retrievers to Trevo and Solitaire or intra-arterial alteplase?. ### Response: 40.


Instruction: How many patients were treated with intra-arterial alteplase alone?

Output: no

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with intra-arterial alteplase alone?. ### Response: no.


Instruction: How many of the patients had treatment with a second modality?

Output: Twenty-four

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many of the patients had treatment with a second modality?. ### Response: Twenty-four.


Instruction: What was used in THRACE?

Output: intra-arterial lytic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was used in THRACE?. ### Response: intra-arterial lytic.


Instruction: What may be preferable to high-intensity statin therapy?

Output: moderate-intensity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be preferable to high-intensity statin therapy?. ### Response: moderate-intensity.


Instruction: What should be considered in patients over 75 years of age with ASCVD?

Output: continuation of high-intensity therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered in patients over 75 years of age with ASCVD?. ### Response: continuation of high-intensity therapy.


Instruction: What should be based on in patients >75 years of age with ASCVD?

Output: expected benefit versus competing comorbidities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be based on in patients >75 years of age with ASCVD?. ### Response: expected benefit versus competing comorbidities.


Instruction: What age reported in clinical trials of statin therapy represents the patient’s age at study entry?

Output: S4.1-23–S4.1-318

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What age reported in clinical trials of statin therapy represents the patient’s age at study entry?. ### Response: S4.1-23–S4.1-318.


Instruction: What is rea-sonable to continue high-intensity therapy in patients >75 years of age with ASCVD if they are tolerating the statin and have a low risk of competing morbidities?

Output: S4.1-23

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is rea-sonable to continue high-intensity therapy in patients >75 years of age with ASCVD if they are tolerating the statin and have a low risk of competing morbidities?. ### Response: S4.1-23.


Instruction: What has not shown an adverse effect of statin therapy on cognition?

Output: S4.1-33,S4.1-35,S4.1-36

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has not shown an adverse effect of statin therapy on cognition?. ### Response: S4.1-33,S4.1-35,S4.1-36.


Instruction: What type of statin therapy reduces ASCVD events, but is less effective than high-intensity therapy?

Output: moderate-intensity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of statin therapy reduces ASCVD events, but is less effective than high-intensity therapy?. ### Response: moderate-intensity.


Instruction: What is the reason for this difference?

Output: differences in LDL-C–lowering potency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the reason for this difference?. ### Response: differences in LDL-C–lowering potency.


Instruction: Why is this difference pre-sumably due to differences in LDL-C-lowering potency?

Output: moderate-intensity statin therapy reduces ASCVD events, it is less effective than high-intensity therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is this difference pre-sumably due to differences in LDL-C-lowering potency?. ### Response: moderate-intensity statin therapy reduces ASCVD events, it is less effective than high-intensity therapy.


Instruction: What is ezetimibe?

Output: enhanced risk reduc-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ezetimibe?. ### Response: enhanced risk reduc-tion.


Instruction: What could be produced by the combi-nation of moderative-intensity statin and ezetimbe? What is supported by the finding that ezetivimibe and a moderate intensity statin can reduce ASCVD risk?

Output: a level of ASCVD risk reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could be produced by the combi-nation of moderative-intensity statin and ezetimbe? What is supported by the finding that ezetivimibe and a moderate intensity statin can reduce ASCVD risk?. ### Response: a level of ASCVD risk reduction.


Instruction: What did ezetimibe enhance when combined with moderate-intensity therapy in patients after ACS?

Output: risk reduc-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did ezetimibe enhance when combined with moderate-intensity therapy in patients after ACS?. ### Response: risk reduc-tion.


Instruction: What type of therapy is indicated but cannot be used?

Output: high-intensity therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is indicated but cannot be used?. ### Response: high-intensity therapy.


Instruction: What is the LDL-C level of a patient on moderate-intensity therapy?

Output: ≥70 mg/dL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the LDL-C level of a patient on moderate-intensity therapy?. ### Response: ≥70 mg/dL.


Instruction: On what type of statin therapy is a 70 mg/dL (1.8 mmol/L) patient able to tolerate?

Output: maximally tolerated

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On what type of statin therapy is a 70 mg/dL (1.8 mmol/L) patient able to tolerate?. ### Response: maximally tolerated.


Instruction: What is CORONA?

Output: Controlled Rosuvastatin Multi-national Trial in Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CORONA?. ### Response: Controlled Rosuvastatin Multi-national Trial in Heart Failure.


Instruction: What is GISSI HF trial?

Output: Effects of n-3 PUFA and Rosuvastatin on Mortality-Morbidity of Patients With Symptomatic CHF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is GISSI HF trial?. ### Response: Effects of n-3 PUFA and Rosuvastatin on Mortality-Morbidity of Patients With Symptomatic CHF.


Instruction: How many patients have ischemic and nonischemic HF?

Output: 39

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients have ischemic and nonischemic HF?. ### Response: 39.


Instruction: What percentage of patients with nonischemic HF had left ventricular ejection fraction >40%?

Output: 9.8%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients with nonischemic HF had left ventricular ejection fraction >40%?. ### Response: 9.8%.


Instruction: What was the primary outcome of the rosuv-astatin-placebo trial?

Output: low risk of competing morbidities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary outcome of the rosuv-astatin-placebo trial?. ### Response: low risk of competing morbidities.


Instruction: How much did the 10 mg dose of Rosuvastatin reduce the risk of?

Output: total hospitalizations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much did the 10 mg dose of Rosuvastatin reduce the risk of?. ### Response: total hospitalizations.


Instruction: How many hospitalizations were there for a cardiovascular cause in CORONA?

Output: 38

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many hospitalizations were there for a cardiovascular cause in CORONA?. ### Response: 38.


Instruction: What did a subsequent analysis accounting for repeat HF hospitalization show?

Output: significant reduction in HF hospitalizations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a subsequent analysis accounting for repeat HF hospitalization show?. ### Response: significant reduction in HF hospitalizations.


Instruction: What is the International ST2 Consensus Panel?

Output: sated heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the International ST2 Consensus Panel?. ### Response: sated heart failure.


Instruction: What does Galectin 3 complement in risk stratification?

Output: BNP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Galectin 3 complement in risk stratification?. ### Response: BNP.


Instruction: What complements BNP in risk stratification in acute heart failure?

Output: Galectin 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What complements BNP in risk stratification in acute heart failure?. ### Response: Galectin 3.


Instruction: What is the Multinational Observational Cohort on Acute Heart Failure study called?

Output: MOCA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Multinational Observational Cohort on Acute Heart Failure study called?. ### Response: MOCA.


Instruction: What is the MOCA study?

Output: Multinational Observational Cohort on Acute Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the MOCA study?. ### Response: Multinational Observational Cohort on Acute Heart Failure.


Instruction: What was the result of the COoperative North Scandinavian Enalapril Survival Study?

Output: Effects of enalapril on mortality in severe congestive heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the result of the COoperative North Scandinavian Enalapril Survival Study?. ### Response: Effects of enalapril on mortality in severe congestive heart failure.


Instruction: When did the CONSENSUS Trial Study Group publish?

Output: 1987

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the CONSENSUS Trial Study Group publish?. ### Response: 1987.


Instruction: What is the effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure?

Output: 129

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure?. ### Response: 129.


Instruction: What was the N Engl J Med. 1991;325:293–302?

Output: The SOLVD Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the N Engl J Med. 1991;325:293–302?. ### Response: The SOLVD Investigators.


Instruction: How did Packer M compare the effects of low and high doses of angiotensin-converting enzyme?

Output: Comparative effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Packer M compare the effects of low and high doses of angiotensin-converting enzyme?. ### Response: Comparative effects.


Instruction: What is the name of the angiotensin-converting enzyme inhibitor?

Output: Galectin 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the angiotensin-converting enzyme inhibitor?. ### Response: Galectin 3.


Instruction: When was this publication released?

Output: May 3, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this publication released?. ### Response: May 3, 2023.


Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al.


Instruction: What may increase the risk of an embolic infarct converting to a hemorrhagic infarction?

Output: Anticoagulant therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may increase the risk of an embolic infarct converting to a hemorrhagic infarction?. ### Response: Anticoagulant therapy.


Instruction: What is the risk of embolic infarct converting to?

Output: hemorrhagic infarct

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of embolic infarct converting to?. ### Response: hemorrhagic infarct.


Instruction: What is a risk of recurrent embolization and valve dysfunction?

Output: higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk of recurrent embolization and valve dysfunction?. ### Response: higher.


Instruction: Who should be added to the Heart Valve Team?

Output: A specialist in the field of neu-rology or neuroradiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should be added to the Heart Valve Team?. ### Response: A specialist in the field of neu-rology or neuroradiology.


Instruction: What should be added to the Heart Valve Team when stroke complicates IE.11,18–244?

Output: A specialist in the field of neu-rology or neuroradiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be added to the Heart Valve Team when stroke complicates IE.11,18–244?. ### Response: A specialist in the field of neu-rology or neuroradiology.


Instruction: What did POET randomize stable patients with left-sided endocarditis caused by streptococcus?

Output: treatment arms of contin-ued intravenous treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did POET randomize stable patients with left-sided endocarditis caused by streptococcus?. ### Response: treatment arms of contin-ued intravenous treatment.


Instruction: How long had antibiotics been administered intravenously for?

Output: at least 10 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long had antibiotics been administered intravenously for?. ### Response: at least 10 days.


Instruction: What was per -formed within 1 to 3 days before the completion of the antibiotic treatment?

Output: TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was per -formed within 1 to 3 days before the completion of the antibiotic treatment?. ### Response: TEE.


Instruction: What is not recommended in patients with native valve endocarditis?

Output: rou-tine use of VKA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended in patients with native valve endocarditis?. ### Response: rou-tine use of VKA.


Instruction: What should be considered in patients on VKA for other indications who have IE?

Output: VKA discontinuation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered in patients on VKA for other indications who have IE?. ### Response: VKA discontinuation.


Instruction: What is required in about 50% of patients with prosthetic valve endocarditis?

Output: early surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is required in about 50% of patients with prosthetic valve endocarditis?. ### Response: early surgery.


Instruction: What is the risk of bleeding associated with any needed urgent invasive procedures?

Output: hemorrhagic infarct

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of bleeding associated with any needed urgent invasive procedures?. ### Response: hemorrhagic infarct.


Instruction: What is valve endocarditis?

Output: prosthetic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is valve endocarditis?. ### Response: prosthetic.


Instruction: There are no RCTs studying the use of what in patients with IE?

Output: bridging therapy with intravenous or subcutaneous anticoagulant ther -apy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There are no RCTs studying the use of what in patients with IE?. ### Response: bridging therapy with intravenous or subcutaneous anticoagulant ther -apy.


Instruction: What suggest an increased risk of hemorrhagic stroke in patients on intravenous UFH during the acute phase of acute IE in patients?

Output: observational studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What suggest an increased risk of hemorrhagic stroke in patients on intravenous UFH during the acute phase of acute IE in patients?. ### Response: observational studies.


Instruction: What should the patient's cardiologist and cardiothoracic surgeon decide on?

Output: continued anticoagulation and antiplatelet therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should the patient's cardiologist and cardiothoracic surgeon decide on?. ### Response: continued anticoagulation and antiplatelet therapy.


Instruction: What should a neurology specialist do if neurological findings are clinically present?

Output: noted on imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should a neurology specialist do if neurological findings are clinically present?. ### Response: noted on imaging.


Instruction: How many sets of blood culture samples are the mini-mum for a patient?

Output: Two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many sets of blood culture samples are the mini-mum for a patient?. ### Response: Two.


Instruction: What is the mini-mum for a secure microbiological diagnosis of IE?

Output: Two sets of blood culture samples

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the mini-mum for a secure microbiological diagnosis of IE?. ### Response: Two sets of blood culture samples.


Instruction: Figure 15. Diagnosis of what?

Output: IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Figure 15. Diagnosis of what?. ### Response: IE.


Instruction: What indicates computed tomography?

Output: CT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates computed tomography?. ### Response: CT.


Instruction: What is PVE?

Output: prosthetic valve endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PVE?. ### Response: prosthetic valve endocarditis.


Instruction: What is TEE?

Output: transesophageal echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is TEE?. ### Response: transesophageal echocardiography.


Instruction: When was the file downloaded?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the file downloaded?. ### Response: April 28, 2023.


Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al.


Instruction: When did Otto and colleagues publish their guideline?

Output: 2020 ACC/AHA Guideline for the Management of Valvular Heart DiseaseCirculation. 2021;143:e72–e227. DOI: 10.1161/CIR.0000000000000923 February 2, 2021

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Otto and colleagues publish their guideline?. ### Response: 2020 ACC/AHA Guideline for the Management of Valvular Heart DiseaseCirculation. 2021;143:e72–e227. DOI: 10.1161/CIR.0000000000000923 February 2, 2021.


Instruction: What should be made in a shared decision-mak-ing process that must be shared?

Output: bioprosthetic valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be made in a shared decision-mak-ing process that must be shared?. ### Response: bioprosthetic valve replacement.


Instruction: What should be made in a shared decision-mak-ing process that must account for the trade-offs between durability, bleeding, and thromboembolism?

Output: bioprosthetic valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be made in a shared decision-mak-ing process that must account for the trade-offs between durability, bleeding, and thromboembolism?. ### Response: bioprosthetic valve replacement.


Instruction: In patients >65 years of age at the time of bio-prosthetic AVR, the likelihood of primary struc-tural deterioration at 15 to 20 years is about what?

Output: 10%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients >65 years of age at the time of bio-prosthetic AVR, the likelihood of primary struc-tural deterioration at 15 to 20 years is about what?. ### Response: 10%..


Instruction: How much is struc-tural deterioration at 15 to 20 years?

Output: about 10%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much is struc-tural deterioration at 15 to 20 years?. ### Response: about 10%..


Instruction: Older patients are at higher risk of bleeding complications related to what?

Output: VKA ther -apy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Older patients are at higher risk of bleeding complications related to what?. ### Response: VKA ther -apy.


Instruction: What is reasonable to use a bioprosthetic valve in noncardiac surgical and interventional procedures?

Output: to avoid the risks of anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable to use a bioprosthetic valve in noncardiac surgical and interventional procedures?. ### Response: to avoid the risks of anticoagulation.


Instruction: Why is it reasonable to use a bioprosthetic valve in patients >65 years of age?

Output: to avoid the risks of anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is it reasonable to use a bioprosthetic valve in patients >65 years of age?. ### Response: to avoid the risks of anticoagulation.


Instruction: What does the durability of the valve exceed?

Output: expected years of life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the durability of the valve exceed?. ### Response: expected years of life.


Instruction: Patients with mechanical valve replace-ment experience a higher risk of bleeding because of what?

Output: anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with mechanical valve replace-ment experience a higher risk of bleeding because of what?. ### Response: anticoagulation.


Instruction: Why do people who receive a bioprosthetic valve replacement incur a higher risk of bleeding?

Output: structural valve deterioration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why do people who receive a bioprosthetic valve replacement incur a higher risk of bleeding?. ### Response: structural valve deterioration.


Instruction: What is the risk of repeat intervention attributable to?

Output: structural valve deterioration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of repeat intervention attributable to?. ### Response: structural valve deterioration.


Instruction: In patients 65 years of age, observational data suggest better long-term outcomes with what type of replacement?

Output: bio-prosthetic mitral valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients 65 years of age, observational data suggest better long-term outcomes with what type of replacement?. ### Response: bio-prosthetic mitral valve replacement.


Instruction: What is the name of the New York Statewide Planning and Research Cooperative System?

Output: SPARCS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the New York Statewide Planning and Research Cooperative System?. ### Response: SPARCS.


Instruction: What was the outcome of a mechanical mitral valve replacement even when the risks and inconvenience of long-term VKA anticoagulation are considered?

Output: better long-term outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome of a mechanical mitral valve replacement even when the risks and inconvenience of long-term VKA anticoagulation are considered?. ### Response: better long-term outcomes.


Instruction: What were the rates of reoperation with a mechanical valve?

Output: lower (HR: 0.59

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the rates of reoperation with a mechanical valve?. ### Response: lower (HR: 0.59.


Instruction: What was the rate of stroke risk?

Output: 1.62

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the rate of stroke risk?. ### Response: 1.62.


Instruction: Where was the 2017 report from?

Output: California Office of Statewide Health Planning and Development

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where was the 2017 report from?. ### Response: California Office of Statewide Health Planning and Development.