Instruction: What is the name of the new oral anticoagulants that target different parts of the coagulation path-way?

Output: 2.1.6 New Oral Anticoagulants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the new oral anticoagulants that target different parts of the coagulation path-way?. ### Response: 2.1.6 New Oral Anticoagulants.


Instruction: What are direct thrombin inhibitors?

Output: dabigatran) and direct factor Xa inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are direct thrombin inhibitors?. ### Response: dabigatran) and direct factor Xa inhibitors.


Instruction: What is a direct thrombin inhibitor?

Output: dabigatran

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a direct thrombin inhibitor?. ### Response: dabigatran.


Instruction: What are apixa-ban, rivaroxaban, and edoxaban?

Output: direct factor Xa inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are apixa-ban, rivaroxaban, and edoxaban?. ### Response: direct factor Xa inhibitors.


Instruction: When will results of large phase 3 clinical trials of these agents be published?

Output: soon

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When will results of large phase 3 clinical trials of these agents be published?. ### Response: soon.


Instruction: Why is ximelagatran no longer approved for use by regulatory agencies?

Output: concerns about severe liver toxicity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is ximelagatran no longer approved for use by regulatory agencies?. ### Response: concerns about severe liver toxicity.


Instruction: What was a proof of principle that a direct thrombin inhibitor can achieve?

Output: similar protection against stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a proof of principle that a direct thrombin inhibitor can achieve?. ### Response: similar protection against stroke.


Instruction: What type of inhibitor can achieve similar protection against stroke compared to warfarin?

Output: direct thrombin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of inhibitor can achieve similar protection against stroke compared to warfarin?. ### Response: direct thrombin.


Instruction: What is the proof of principle?

Output: combination therapy is more effective in reducing the risk of nonfatal stroke in patients with AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the proof of principle?. ### Response: combination therapy is more effective in reducing the risk of nonfatal stroke in patients with AF.


Instruction: What is the name of the Randomized Evaluation of Long-Term Anti-coagulation Therapy trial?

Output: RE-LY

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Randomized Evaluation of Long-Term Anti-coagulation Therapy trial?. ### Response: RE-LY.


Instruction: Who reported the RE-LY trial on February 10, 2012?

Output: Kimberly Henricks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who reported the RE-LY trial on February 10, 2012?. ### Response: Kimberly Henricks.


Instruction: What was Kimberly Henricks' name?

Output: American College of Chest Physicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was Kimberly Henricks' name?. ### Response: American College of Chest Physicians.


Instruction: What is the recurrence rate for SVT after successful procedures?

Output: 7% to 17%;

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recurrence rate for SVT after successful procedures?. ### Response: 7% to 17%;.


Instruction: What is a possible limitation of access for subsequent catheter-based pro-cedures?

Output: SVT or tachycardia-induced cardiomyopathy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a possible limitation of access for subsequent catheter-based pro-cedures?. ### Response: SVT or tachycardia-induced cardiomyopathy.


Instruction: When was e548 Circulation?

Output: April 5, 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was e548 Circulation?. ### Response: April 5, 2016.


Instruction: What is the highest rate of recurrence among right-sided accessory pathways?

Output: 427–429

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the highest rate of recurrence among right-sided accessory pathways?. ### Response: 427–429.


Instruction: What is most common in young patients with ectopic tachycardia?

Output: congenital form or, more commonly, after intracardiac repair of congenital heart dis-ease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is most common in young patients with ectopic tachycardia?. ### Response: congenital form or, more commonly, after intracardiac repair of congenital heart dis-ease.


Instruction: What type of tachycardia occurs in very young patients?

Output: Junctional ectopic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of tachycardia occurs in very young patients?. ### Response: Junctional ectopic.


Instruction: What is the most common cause of nonpostoperative junctional TCA?

Output: congenital heart dis-ease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common cause of nonpostoperative junctional TCA?. ### Response: congenital heart dis-ease.


Instruction: How has nonpostoperative junctional tacticardia been reported to respond to?

Output: amiodarone or combination therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How has nonpostoperative junctional tacticardia been reported to respond to?. ### Response: amiodarone or combination therapy.


Instruction: What is the efficacy of ablation for patients with refractory tachycardia or ventricular dysfunction?

Output: 82% to 85%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the efficacy of ablation for patients with refractory tachycardia or ventricular dysfunction?. ### Response: 82% to 85%,.


Instruction: What was seen in 14% of patients with inadvertent A V block?

Output: recurrence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was seen in 14% of patients with inadvertent A V block?. ### Response: recurrence.


Instruction: How many young patients undergo intracardiac surgery?

Output: 2% to 10%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many young patients undergo intracardiac surgery?. ### Response: 2% to 10%.


Instruction: What percentage of young patients undergo intracardiac surgery?

Output: 2% to 10%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of young patients undergo intracardiac surgery?. ### Response: 2% to 10%.


Instruction: What is the treatment for ventricular or A V septal defects?

Output: Ablation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the treatment for ventricular or A V septal defects?. ### Response: Ablation.


Instruction: Temperature to 34 to 35°C, atrial overdrive pacing, and procainamide or amiodarone infusions?

Output: core temperature

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Temperature to 34 to 35°C, atrial overdrive pacing, and procainamide or amiodarone infusions?. ### Response: core temperature.


Instruction: Postoperative junctional tachycardia resolves and does not require what?

Output: ongoing therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Postoperative junctional tachycardia resolves and does not require what?. ### Response: ongoing therapy.


Instruction: SVT may occur in the fetus and, if sustained, may put what at risk?

Output: cardiovascular collapse

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: SVT may occur in the fetus and, if sustained, may put what at risk?. ### Response: cardiovascular collapse.


Instruction: What is the most common mechanism for fetal SVT?

Output: A VRT and atrial flutter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common mechanism for fetal SVT?. ### Response: A VRT and atrial flutter.


Instruction: What is a high mortality rate associated with persistent SVT with hydrops?

Output: 436

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a high mortality rate associated with persistent SVT with hydrops?. ### Response: 436.


Instruction: What carries a high mortality rate with hydrops?

Output: Persistent SVT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What carries a high mortality rate with hydrops?. ### Response: Persistent SVT.


Instruction: What has been shown to be effective through transplacental delivery?

Output: Maternal administration of antiarrhythmic agents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been shown to be effective through transplacental delivery?. ### Response: Maternal administration of antiarrhythmic agents.


Instruction: Flecainide, sotalol, and digoxin have demonstrated arrhythmia termination rates of what?

Output: 60% to 90%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Flecainide, sotalol, and digoxin have demonstrated arrhythmia termination rates of what?. ### Response: 60% to 90%,.


Instruction: What is the rate of arrhythmia termination?

Output: 60% to 90%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the rate of arrhythmia termination?. ### Response: 60% to 90%,.


Instruction: What is amiodarone used for in cases refractory to the aforementioned drugs?

Output: maternal oral loading for 2 to 7 days with amiodarone may prove lifesaving

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is amiodarone used for in cases refractory to the aforementioned drugs?. ### Response: maternal oral loading for 2 to 7 days with amiodarone may prove lifesaving.


Instruction: How long does maternal oral loading of a woman with a fetal SVT last?

Output: 2 to 7 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does maternal oral loading of a woman with a fetal SVT last?. ### Response: 2 to 7 days.


Instruction: What is the treatment of arrhythmias in women during pregnancy addressed in Section 9.3 of Figure 18?

Output: Treatment of fetal SVT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the treatment of arrhythmias in women during pregnancy addressed in Section 9.3 of Figure 18?. ### Response: Treatment of fetal SVT.


Instruction: What corresponds to Class of Recommendation in Table 1?

Output: Colors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What corresponds to Class of Recommendation in Table 1?. ### Response: Colors.


Instruction: How are drugs listed?

Output: alphabetically

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are drugs listed?. ### Response: alphabetically.


Instruction: What have many observational studies followed patients over time to determine?

Output: how many develop hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have many observational studies followed patients over time to determine?. ### Response: how many develop hypertension.


Instruction: How many patients develop hypertension at intervals of 1 to 5 y?

Output: 15,164

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients develop hypertension at intervals of 1 to 5 y?. ### Response: 15,164.


Instruction: What does the USPSTF recommend screening for?

Output: HBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the USPSTF recommend screening for?. ### Response: HBP.


Instruction: Who recommends obtaining measurements outside of the clinical setting for diagnostic confirmation before starting treatment?

Output: USPSTF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who recommends obtaining measurements outside of the clinical setting for diagnostic confirmation before starting treatment?. ### Response: USPSTF.


Instruction: What does ABPM mean?

Output: ambulatory blood pressure monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ABPM mean?. ### Response: ambulatory blood pressure monitoring.


Instruction: What is the acronym for diastolic blood pressure?

Output: DBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for diastolic blood pressure?. ### Response: DBP.


Instruction: What is HBPM?

Output: home blood pressure monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is HBPM?. ### Response: home blood pressure monitoring.


Instruction: Where is the USPSTF located?

Output: US Preventive Services Task Force

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the USPSTF located?. ### Response: US Preventive Services Task Force.


Instruction: When was the version of this article published?

Output: May 3, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the version of this article published?. ### Response: May 3, 2023.


Instruction: What are readers advised to follow inconjunction with the drug manufacturer’s own publishedliterature?

Output: new methods and techniques involving drug usage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are readers advised to follow inconjunction with the drug manufacturer’s own publishedliterature?. ### Response: new methods and techniques involving drug usage.


Instruction: What is a well-established cardiovascular risk factor?

Output: meta-bolic syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a well-established cardiovascular risk factor?. ### Response: meta-bolic syndrome.


Instruction: What is the meta-bolic syndrome common among patients undergoing CABG?

Output: cardiovascular risk factor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the meta-bolic syndrome common among patients undergoing CABG?. ### Response: cardiovascular risk factor.


Instruction: What is the prevalence of metabolic syndrome?

Output: 50%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the prevalence of metabolic syndrome?. ### Response: 50%..


Instruction: What has been associated with increased in-hospital mortality in subjects undergoing CABG?

Output: The metabolic syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been associated with increased in-hospital mortality in subjects undergoing CABG?. ### Response: The metabolic syndrome.


Instruction: In a study of 5304 consecutive CABG patients, those with metabolic syn-drome had what?

Output: a 2.7-times higher in-hospital mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In a study of 5304 consecutive CABG patients, those with metabolic syn-drome had what?. ### Response: a 2.7-times higher in-hospital mortality.


Instruction: What is a risk that was independent of the presence of diabetes mellitus?

Output: metabolic syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk that was independent of the presence of diabetes mellitus?. ### Response: metabolic syndrome.


Instruction: Patients with metabolic syndrome also have an increased risk for what?

Output: long-term mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with metabolic syndrome also have an increased risk for what?. ### Response: long-term mortality.


Instruction: How much higher was all-cause mortality in those patients with the metabolic syndrome compared with those without?

Output: 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much higher was all-cause mortality in those patients with the metabolic syndrome compared with those without?. ### Response: 50%.


Instruction: How many CABG patients had the metabolic syndrome?

Output: 5304

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many CABG patients had the metabolic syndrome?. ### Response: 5304.


Instruction: What was the long-term risk for cardiac arrhythmias, renal failure, and composite outcome of major adverse cardiovascular events?

Output: 52.4%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the long-term risk for cardiac arrhythmias, renal failure, and composite outcome of major adverse cardiovascular events?. ### Response: 52.4%.


Instruction: How many times more likely to die from the meta-bolic syndrome than those without it?

Output: 2.7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many times more likely to die from the meta-bolic syndrome than those without it?. ### Response: 2.7.


Instruction: How many times more likely are patients with meta-bolic syndrome to develop AF after CABG?

Output: 2.3-times

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many times more likely are patients with meta-bolic syndrome to develop AF after CABG?. ### Response: 2.3-times.


Instruction: What may be mediated by an elevated C-reactive protein level?

Output: increased risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be mediated by an elevated C-reactive protein level?. ### Response: increased risk.


Instruction: Patients with metabolic syndrome are also at risk for what?

Output: long-term mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with metabolic syndrome are also at risk for what?. ### Response: long-term mortality.


Instruction: What type of grafts are used after CABG?

Output: saphenous vein

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of grafts are used after CABG?. ### Response: saphenous vein.


Instruction: What are the multiple pathophysiological mechanisms linking obesity and cardiovascular disease?

Output: comorbidities such as heart failure, cancer, and lung diseases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the multiple pathophysiological mechanisms linking obesity and cardiovascular disease?. ### Response: comorbidities such as heart failure, cancer, and lung diseases.


Instruction: There is minimal evidence proving any benefit associated with weight loss after what procedure?

Output: CABG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is minimal evidence proving any benefit associated with weight loss after what procedure?. ### Response: CABG.


Instruction: What type of studies have shown worse outcomes among patients losing weight after CABG?

Output: Retrospective, observational studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of studies have shown worse outcomes among patients losing weight after CABG?. ### Response: Retrospective, observational studies.


Instruction: What kind of weight loss could reflect comorbidities such as diabetes?

Output: CABG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What kind of weight loss could reflect comorbidities such as diabetes?. ### Response: CABG.


Instruction: What could unintentional weight loss reflect?

Output: comorbidities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could unintentional weight loss reflect?. ### Response: comorbidities.


Instruction: What could be a comorbidity of heart failure, cancer, and lung diseases?

Output: Unintentional weight loss

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could be a comorbidity of heart failure, cancer, and lung diseases?. ### Response: Unintentional weight loss.


Instruction: In what setting was weight loss in CAD patients based?

Output: CR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what setting was weight loss in CAD patients based?. ### Response: CR.


Instruction: Weight loss has an indisputable benefit for BP, diabetes mellitus, and lipid control and improves what?

Output: quality of life and functional capacity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Weight loss has an indisputable benefit for BP, diabetes mellitus, and lipid control and improves what?. ### Response: quality of life and functional capacity.


Instruction: What should be recommended for overweight or obese patients after CABG?

Output: weight loss

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be recommended for overweight or obese patients after CABG?. ### Response: weight loss.


Instruction: How long-term, successful weight loss continues to represent a major clinical challenge?

Output: Long-term, successful weight loss continues to represent a major clinical challenge. Most studies have noted that much of the weight lost in the first 6 months is regained at 1 year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long-term, successful weight loss continues to represent a major clinical challenge?. ### Response: Long-term, successful weight loss continues to represent a major clinical challenge. Most studies have noted that much of the weight lost in the first 6 months is regained at 1 year.


Instruction: How much of the weight lost in the first 6 months is regained at 1 year?

Output: Most studies have noted that much

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the weight lost in the first 6 months is regained at 1 year?. ### Response: Most studies have noted that much.


Instruction: What are the therapeutic options to achieve successful weight loss?

Output: The therapeutic options

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the therapeutic options to achieve successful weight loss?. ### Response: The therapeutic options.


Instruction: What is the short title of the 2017 AHA/ACC STEMI/NSTEMI Measure Set?

Output: QM-4: Aldosterone Antagonist at Discharge

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the short title of the 2017 AHA/ACC STEMI/NSTEMI Measure Set?. ### Response: QM-4: Aldosterone Antagonist at Discharge.


Instruction: How old are eligible patients with AMI who are prescribed an aldosterone antagonist at hospital discharge?

Output: ≥18 y

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old are eligible patients with AMI who are prescribed an aldosterone antagonist at hospital discharge?. ### Response: ≥18 y.


Instruction: What is an aldosterone antagonist prescribed at hospital discharge?

Output: eligible patients, age ≥18 y, hospitalized with AMI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an aldosterone antagonist prescribed at hospital discharge?. ### Response: eligible patients, age ≥18 y, hospitalized with AMI.


Instruction: What are patients with AMI who are already receiving an ACE inhibitor and beta blocker and have an EF 40% and either HF or diabetes mellitus?

Output: [a]

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients with AMI who are already receiving an ACE inhibitor and beta blocker and have an EF 40% and either HF or diabetes mellitus?. ### Response: [a].


Instruction: What percentage of EF do patients with diabetes have?

Output: ≤40%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of EF do patients with diabetes have?. ### Response: ≤40%,.


Instruction: What is appropriate when ACE inhibitor and beta blocker cannot be used or tolerated?

Output: aldosterone antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is appropriate when ACE inhibitor and beta blocker cannot be used or tolerated?. ### Response: aldosterone antagonists.


Instruction: What percentage of LVEF do patients with diabetes mellitus or HFD have?

Output: ≤40%;

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of LVEF do patients with diabetes mellitus or HFD have?. ### Response: ≤40%;.


Instruction: What is the maximum age for patients who leave against medical advice?

Output: <18 y

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the maximum age for patients who leave against medical advice?. ### Response: <18 y.


Instruction: Patients who die during hospitalization who are on comfort care measures or hospice?

Output: Patients who are on comfort care measures only or hospicePatients who are transferred to another hospital for inpatient acute care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients who die during hospitalization who are on comfort care measures or hospice?. ### Response: Patients who are on comfort care measures only or hospicePatients who are transferred to another hospital for inpatient acute care.


Instruction: What is a medical reason for not prescribing an aldosterone antagonist at hospital discharge?

Output: allergy or intolerance to aldosterone antagonist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a medical reason for not prescribing an aldosterone antagonist at hospital discharge?. ### Response: allergy or intolerance to aldosterone antagonist.


Instruction: What is the name of a patient currently enrolled in a hospital for inpatient acute care?

Output: age ≥18 y

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of a patient currently enrolled in a hospital for inpatient acute care?. ### Response: age ≥18 y.


Instruction: What type of hyperkalemia is found in women?

Output: >2.0 mg/dL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of hyperkalemia is found in women?. ### Response: >2.0 mg/dL.


Instruction: What is the name of the clinical trial that is currently enrolled in a patient?

Output: renin-angiot

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the clinical trial that is currently enrolled in a patient?. ### Response: renin-angiot.


Instruction: What is EPHESUS?

Output: Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is EPHESUS?. ### Response: Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival.


Instruction: What percentage of patients had benefits from adding eplerenone to ACE inhibitors and beta blockers?

Output: ≤40%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients had benefits from adding eplerenone to ACE inhibitors and beta blockers?. ### Response: ≤40%,.


Instruction: What is the reduction in overall and cardiovascular mortality?

Output: 17%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the reduction in overall and cardiovascular mortality?. ### Response: 17%.


Instruction: What may post-MI patients with HF benefit from adding an aldosterone antagonist to an ACE inhibitor?

Output: absence of contraindications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may post-MI patients with HF benefit from adding an aldosterone antagonist to an ACE inhibitor?. ### Response: absence of contraindications.


Instruction: What should patients' renal function, electrolytes, and blood pressure be screened for?

Output: hyperkalemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients' renal function, electrolytes, and blood pressure be screened for?. ### Response: hyperkalemia.


Instruction: What should be given to patients with STEMI who are already receiving an ACE inhibitor and beta blocker?

Output: An aldosterone antagonist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be given to patients with STEMI who are already receiving an ACE inhibitor and beta blocker?. ### Response: An aldosterone antagonist.


Instruction: What is the AHA/ACC Guideline for the Management of Patients with Non-ST-Elevation Acute Coronary Syndromes?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the AHA/ACC Guideline for the Management of Patients with Non-ST-Elevation Acute Coronary Syndromes?. ### Response: 2014.


Instruction: What is EF less than or equal to 0.40 and symptomatic HF or diabetes mellitus?

Output: ≤40%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is EF less than or equal to 0.40 and symptomatic HF or diabetes mellitus?. ### Response: ≤40%,.


Instruction: What is the ACC/AHA guideline on the Primary Prevention of Cardiovascular Disease?

Output: 2019

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ACC/AHA guideline on the Primary Prevention of Cardiovascular Disease?. ### Response: 2019.


Instruction: What was the 10-year risk of “hard ASCVD”?

Output: 8.7%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 10-year risk of “hard ASCVD”?. ### Response: 8.7%,.


Instruction: How much was the risk of the expanded asCVD end-point that included coronary revascularization?

Output: 10%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much was the risk of the expanded asCVD end-point that included coronary revascularization?. ### Response: 10%..


Instruction: What percentage included coronary revascularization?

Output: 10%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage included coronary revascularization?. ### Response: 10%..


Instruction: After 5.6 years, those assigned to rosuvastatin 10 mg per day showed significant absolute risk reduction in both co-primary end-points with an acceptable safety record?

Output: S4.3-9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: After 5.6 years, those assigned to rosuvastatin 10 mg per day showed significant absolute risk reduction in both co-primary end-points with an acceptable safety record?. ### Response: S4.3-9.


Instruction: What was the median follow-up of 1.9 years?

Output: those assigned to a high-intensity statin dose of rosuvastatin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the median follow-up of 1.9 years?. ### Response: those assigned to a high-intensity statin dose of rosuvastatin.


Instruction: What was the name of the RCT that evaluated rosuvastatin in a high-intensity statin dose?

Output: JUPITER

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the RCT that evaluated rosuvastatin in a high-intensity statin dose?. ### Response: JUPITER.


Instruction: What did the participants in the JUPITER RCT achieve in relation to LDL-C lowering and ASCVD?

Output: greater reductions in ASCVD outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the participants in the JUPITER RCT achieve in relation to LDL-C lowering and ASCVD?. ### Response: greater reductions in ASCVD outcomes.


Instruction: What is the net benefit of LDL-C-lowering therapy greater with greater reductions in?

Output: ASCVD outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the net benefit of LDL-C-lowering therapy greater with greater reductions in?. ### Response: ASCVD outcomes.


Instruction: What is reasonable to use a high-intensity statin to lower by 50%?

Output: LDL-C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable to use a high-intensity statin to lower by 50%?. ### Response: LDL-C.


Instruction: What percentage of LDL-C is lower?

Output: ≥50%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of LDL-C is lower?. ### Response: ≥50%..


Instruction: What is the 10-year risk of ASCVD?

Output: ≥20%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 10-year risk of ASCVD?. ### Response: ≥20%..


Instruction: Who enrolled men 50 and women 60 years of age with high-sensitivity C-reactive pro-tein values?

Output: JUPITER

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who enrolled men 50 and women 60 years of age with high-sensitivity C-reactive pro-tein values?. ### Response: JUPITER.


Instruction: How many mg per day of rosuvastatin were participants randomly assigned to?

Output: 20

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mg per day of rosuvastatin were participants randomly assigned to?. ### Response: 20.


Instruction: What was the median LDL-C reduc-tion of rosuvastatin?

Output: 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the median LDL-C reduc-tion of rosuvastatin?. ### Response: 50%.


Instruction: How long did it take for ASCVD risk to be reduced?

Output: 1.9 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for ASCVD risk to be reduced?. ### Response: 1.9 years.


Instruction: What did the USPSTF systematic review of statin therapy show?

Output: reduced risk of all-cause and cardio-vascular mortality and ASCVD events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the USPSTF systematic review of statin therapy show?. ### Response: reduced risk of all-cause and cardio-vascular mortality and ASCVD events.


Instruction: What did a review of statin therapy in primary prevention show reduced risk of?

Output: all-cause and cardio-vascular mortality and ASCVD events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a review of statin therapy in primary prevention show reduced risk of?. ### Response: all-cause and cardio-vascular mortality and ASCVD events.


Instruction: What did the review show greater absolute benefits in those at greater base-line risk?

Output: statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the review show greater absolute benefits in those at greater base-line risk?. ### Response: statin therapy.


Instruction: What is the need for aggressive and safe risk reduction in the highest-risk groups?

Output: follow-up LDL-C testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the need for aggressive and safe risk reduction in the highest-risk groups?. ### Response: follow-up LDL-C testing.


Instruction: What is needed to determine adherence and adequacy of effect of the statin prescribed?

Output: follow-up LDL-C testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed to determine adherence and adequacy of effect of the statin prescribed?. ### Response: follow-up LDL-C testing.


Instruction: Most patients 40 to 75 years of age with diabe-tes are at intermediate or high risk?

Output: ASCVD events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Most patients 40 to 75 years of age with diabe-tes are at intermediate or high risk?. ### Response: ASCVD events.


Instruction: How many double-blind primary-prevention RCTs showed significant reductions in ASCVD events in large cohorts with diabetes in this age range?

Output: Three of 4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many double-blind primary-prevention RCTs showed significant reductions in ASCVD events in large cohorts with diabetes in this age range?. ### Response: Three of 4.


Instruction: What did a meta-analysis of these trials find associated with moderate-intensity statin therapy?

Output: a risk reduction of 25%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a meta-analysis of these trials find associated with moderate-intensity statin therapy?. ### Response: a risk reduction of 25%,.


Instruction: What was associated with a risk reduction of 25%,S4.3-13?

Output: moderate-intensity statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with a risk reduction of 25%,S4.3-13?. ### Response: moderate-intensity statin therapy.


Instruction: What is indicated for primary prevention in patients 40 to 75 years old?

Output: moderate-intensity statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is indicated for primary prevention in patients 40 to 75 years old?. ### Response: moderate-intensity statin therapy.


Instruction: What is indicated for primary prevention in patients 40 to 75 years of age?

Output: moderate-intensity statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is indicated for primary prevention in patients 40 to 75 years of age?. ### Response: moderate-intensity statin therapy.


Instruction: What is the title of the Chronic Heart Failure Glossary?

Output: NICE 2018. All rights reserved. Subject to Notice of rights. ISBN: 978 -1-4731 -3093 -7 512 13 Glossary  The NICE Glossary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of the Chronic Heart Failure Glossary?. ### Response: NICE 2018. All rights reserved. Subject to Notice of rights. ISBN: 978 -1-4731 -3093 -7 512 13 Glossary  The NICE Glossary.


Instruction: What are the terms used in the NICE glossary that can be found at www.nice.org.uk/?

Output: 13.1 Guideline -specific terms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the terms used in the NICE glossary that can be found at www.nice.org.uk/?. ### Response: 13.1 Guideline -specific terms.


Instruction: What is the term for unstable angina?

Output: UA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for unstable angina?. ### Response: UA.


Instruction: What is another term for ST-segment elevation myocardial infarction?

Output: STEMI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for ST-segment elevation myocardial infarction?. ### Response: STEMI.


Instruction: Acute heart failure is a sudden worsening of what?

Output: the signs and symptoms of heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Acute heart failure is a sudden worsening of what?. ### Response: the signs and symptoms of heart failure.


Instruction: What is Acute heart failure?

Output: a sudden worsening of the signs and symptoms of heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Acute heart failure?. ### Response: a sudden worsening of the signs and symptoms of heart failure.


Instruction: What are some of the symptoms of Acute Heart Failure?

Output: breathlessness after activity or at rest, feeling tired most of the time and finding exercise exhausting, swollen ankles and legs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the symptoms of Acute Heart Failure?. ### Response: breathlessness after activity or at rest, feeling tired most of the time and finding exercise exhausting, swollen ankles and legs.


Instruction: Where can you find heart failure symptoms?

Output: See heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find heart failure symptoms?. ### Response: See heart failure.


Instruction: How do you feel after exercise?

Output: tired

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do you feel after exercise?. ### Response: tired.


Instruction: What are some of the symptoms of acute kidney injury?

Output: minor loss of kidney function to complete kidney failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the symptoms of acute kidney injury?. ### Response: minor loss of kidney function to complete kidney failure.


Instruction: What is the cause of sudden damage to the kidneys that causes them to not work properly?

Output: Acute kidney injury

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cause of sudden damage to the kidneys that causes them to not work properly?. ### Response: Acute kidney injury.


Instruction: What can AKI range from?

Output: a complication of another serious illness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can AKI range from?. ### Response: a complication of another serious illness.


Instruction: What can range from minor loss of kidney function to complete kidney failure?

Output: Acute kidney injury

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can range from minor loss of kidney function to complete kidney failure?. ### Response: Acute kidney injury.


Instruction: AKI usually happens as a complication of what?

Output: another serious illness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: AKI usually happens as a complication of what?. ### Response: another serious illness.


Instruction: What does angiotensin II prevent from binding to on the muscles surrounding blood vessels?

Output: angiotensin II receptors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does angiotensin II prevent from binding to on the muscles surrounding blood vessels?. ### Response: angiotensin II receptors.


Instruction: What causes blood vessels to enlarge (dilate) and blood pressure to be reduced?

Output: Angiotensin II receptor blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes blood vessels to enlarge (dilate) and blood pressure to be reduced?. ### Response: Angiotensin II receptor blockers.


Instruction: Atrial fibrillation causes an irregular and often abnormally fast what?

Output: heart rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atrial fibrillation causes an irregular and often abnormally fast what?. ### Response: heart rate.


Instruction: What is an irregular and often abnormally fast heart rate?

Output: Atrial fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an irregular and often abnormally fast heart rate?. ### Response: Atrial fibrillation.


Instruction: What is a class of drugs that prevent the stimulation of the adrenergic receptors responsible for increased cardiac action used to control?

Output: Beta -blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a class of drugs that prevent the stimulation of the adrenergic receptors responsible for increased cardiac action used to control?. ### Response: Beta -blockers.


Instruction: What is a medical device used in cardiac resynchronization?

Output: Cardiac resynchronisation therapy  An implanted cardiac resynchronization device

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a medical device used in cardiac resynchronization?. ### Response: Cardiac resynchronisation therapy  An implanted cardiac resynchronization device.


Instruction: What is released in response to changes in pressure inside the heart?

Output: BNP and NT -proBNP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is released in response to changes in pressure inside the heart?. ### Response: BNP and NT -proBNP.


Instruction: What is a medical device used in CRT?

Output: implanted cardiac resynchronization device

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a medical device used in CRT?. ### Response: implanted cardiac resynchronization device.


Instruction: What does a resynchronization device send to the heart muscle?

Output: tiny electrical impulses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does a resynchronization device send to the heart muscle?. ### Response: tiny electrical impulses.


Instruction: What does cardiopulmonary exercise testing assess?

Output: integrative exercise responses involving the pulmonary, cardiovascular, haematopoietic, neuropsychological, and skeletal muscle systems

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does cardiopulmonary exercise testing assess?. ### Response: integrative exercise responses involving the pulmonary, cardiovascular, haematopoietic, neuropsychological, and skeletal muscle systems.


Instruction: What is not adequately reflected through the measurement of individual organ system function?

Output: integrative exercise responses involving the pulmonary, cardiovascular, haematopoietic, neuropsychological, and skeletal muscle systems

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not adequately reflected through the measurement of individual organ system function?. ### Response: integrative exercise responses involving the pulmonary, cardiovascular, haematopoietic, neuropsychological, and skeletal muscle systems.


Instruction: Cardiomyopathy refers to diseases of what?

Output: the heart muscle

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cardiomyopathy refers to diseases of what?. ### Response: the heart muscle.


Instruction: What is a condit ion characterized by a gradual loss of kidney function over time?

Output: Chronic kidney disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a condit ion characterized by a gradual loss of kidney function over time?. ### Response: Chronic kidney disease.


Instruction: Chronic heart failure progressively worsens over what?

Output: time

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Chronic heart failure progressively worsens over what?. ### Response: time.


Instruction: What is chronic obstructive pulmonary disease?

Output: obstructive lung disease characterized by long -term breathing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is chronic obstructive pulmonary disease?. ### Response: obstructive lung disease characterized by long -term breathing.


Instruction: What is a type of obstructive lung disease characterized by long-term breathing problems and poor airflow?

Output: Chronic obstructive pulmonary disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a type of obstructive lung disease characterized by long-term breathing problems and poor airflow?. ### Response: Chronic obstructive pulmonary disease.


Instruction: What is the name of the cluster randomised controlled trial to manage fever, hyperglycaemia, and swallowing dysfunction in acute stroke?

Output: QASC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the cluster randomised controlled trial to manage fever, hyperglycaemia, and swallowing dysfunction in acute stroke?. ### Response: QASC.


Instruction: What does QASC stand for?

Output: acute stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does QASC stand for?. ### Response: acute stroke.


Instruction: When was the Lancet 378:1699-1706 published?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Lancet 378:1699-1706 published?. ### Response: 2011.


Instruction: What is the name of the randomized controlled trial of stroke?

Output: CLOTS 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized controlled trial of stroke?. ### Response: CLOTS 3.


Instruction: What are the results of dysphagia screening after acute ischemic stroke called?

Output: Predictors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of dysphagia screening after acute ischemic stroke called?. ### Response: Predictors.


Instruction: Dysphagia screening and intensified oral hygiene re-duce pneumonia after stroke.

Output: J Neurosci Nurs. 2013;45:139–146

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Dysphagia screening and intensified oral hygiene re-duce pneumonia after stroke.. ### Response: J Neurosci Nurs. 2013;45:139–146.


Instruction: What is the name of the study that aimed to improve oral hygiene in stroke patients?

Output: Cochrane Database

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that aimed to improve oral hygiene in stroke patients?. ### Response: Cochrane Database.


Instruction: What is the Cochrane Database Syst Rev. 2006:CD003864?

Output: Staff-led interven-tions for improving oral hygiene in patients following stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Cochrane Database Syst Rev. 2006:CD003864?. ### Response: Staff-led interven-tions for improving oral hygiene in patients following stroke.


Instruction: What is a risk factor for stroke-associated pneumonia and oral hygiene?

Output: Cerebrov

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for stroke-associated pneumonia and oral hygiene?. ### Response: Cerebrov.


Instruction: What did Dennis M, Lewis S, Cranswick G, Forbes J, do?

Output: FOOD Trial Collaboration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Dennis M, Lewis S, Cranswick G, Forbes J, do?. ### Response: FOOD Trial Collaboration.


Instruction: What did FOOD: a multicentre randomised trial evaluate in patients admitted to hospital with a recent stroke?

Output: feeding policies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did FOOD: a multicentre randomised trial evaluate in patients admitted to hospital with a recent stroke?. ### Response: feeding policies.


Instruction: Who did Geeganage C, Beavan J, Ellender S, Bath PM?

Output: Geeganage C, Beavan J, Ellender S, Bath PM. Interventions for dysphagia and nutritional support in acute and subacute stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who did Geeganage C, Beavan J, Ellender S, Bath PM?. ### Response: Geeganage C, Beavan J, Ellender S, Bath PM. Interventions for dysphagia and nutritional support in acute and subacute stroke.


Instruction: What does CLOTS stand for?

Output: Clots in Legs Or sTockings after Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CLOTS stand for?. ### Response: Clots in Legs Or sTockings after Stroke.


Instruction: What does the Cochrane Database Syt Rev. 2012 do?

Output: 10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Cochrane Database Syt Rev. 2012 do?. ### Response: 10.


Instruction: What is the name of the multicentre randomised controlled trial?

Output: CLOTS 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multicentre randomised controlled trial?. ### Response: CLOTS 3.


Instruction: What does CLOTS 3 reduce the risk of in stroke patients?

Output: deep vein thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CLOTS 3 reduce the risk of in stroke patients?. ### Response: deep vein thrombosis.


Instruction: What is the European Stroke Organisation's guideline for prophylaxis for venous thromboembolism in immobile patients with acute ischaemic stroke?

Output: guide-lines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the European Stroke Organisation's guideline for prophylaxis for venous thromboembolism in immobile patients with acute ischaemic stroke?. ### Response: guide-lines.


Instruction: When did ESO publish their guideline?

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did ESO publish their guideline?. ### Response: 2016.


Instruction: What is a meta-analysis of diagnostic va-lidity studies?

Output: Screening for poststroke major depression

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a meta-analysis of diagnostic va-lidity studies?. ### Response: Screening for poststroke major depression.


Instruction: What is the doi:10.1136/jnnp-2012-304194 271?

Output: J Neurol Neurosurg Psychiatry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the doi:10.1136/jnnp-2012-304194 271?. ### Response: J Neurol Neurosurg Psychiatry.


Instruction: How is depression assessed after stroke?

Output: a comparison of different screening instruments

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is depression assessed after stroke?. ### Response: a comparison of different screening instruments.


Instruction: What is the name of the study that examined screening instruments for depression?

Output: Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined screening instruments for depression?. ### Response: Stroke.


Instruction: How many people were diagnosed with stroke in 2009?

Output: 272

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were diagnosed with stroke in 2009?. ### Response: 272.


Instruction: What was the most recent issue of Stroke?

Output: Eur Stroke J

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the most recent issue of Stroke?. ### Response: Eur Stroke J.


Instruction: What year did the American Medical Association publish its first systematic review of RCTs?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did the American Medical Association publish its first systematic review of RCTs?. ### Response: 2013.


Instruction: Why were the initial search dates for the literature review?

Output: January1,1966,throughDecember31,2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why were the initial search dates for the literature review?. ### Response: January1,1966,throughDecember31,2009.


Instruction: How manypanelmembersreviewed theresults.

Output: Threepanel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How manypanelmembersreviewed theresults.. ### Response: Threepanel.


Instruction: What did the panel vote on for approved evi-dents?

Output: the quality of theevidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the panel vote on for approved evi-dents?. ### Response: the quality of theevidence.


Instruction: The panel voted on the quality of what?

Output: evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The panel voted on the quality of what?. ### Response: evidence.


Instruction: Thepanelreviewedtheevidencestatementstocrafttheclinicalrecommendations,votingoneachrec-ommendationandonwhat?

Output: andonthestrengthoftherecommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Thepanelreviewedtheevidencestatementstocrafttheclinicalrecommendations,votingoneachrec-ommendationandonwhat?. ### Response: andonthestrengthoftherecommendation.


Instruction: What is the title of Chronic Heart Failure Treating Heart Failure?

Output: Chronic Heart Failure  Treating Heart Failure  © NICE 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of Chronic Heart Failure Treating Heart Failure?. ### Response: Chronic Heart Failure  Treating Heart Failure  © NICE 2018.


Instruction: What was the consensus that iron studies were already done for everyone known to have?

Output: anaemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the consensus that iron studies were already done for everyone known to have?. ### Response: anaemia.


Instruction: What is the estimated percentage of HF population?

Output: 10%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the estimated percentage of HF population?. ### Response: 10%.


Instruction: What would people with HF in a specialist clinic generally get?

Output: iron studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would people with HF in a specialist clinic generally get?. ### Response: iron studies.


Instruction: Who would currently not be tested?

Output: a large nu mber

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who would currently not be tested?. ### Response: a large nu mber.


Instruction: What would it be important to raise awareness of iron deficiency in HF amongst non-specialists?

Output: treatment recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would it be important to raise awareness of iron deficiency in HF amongst non-specialists?. ### Response: treatment recommendation.


Instruction: What is important to ensure equity of access to treatment?

Output: raise awareness of iron -deficiency in HF amongst non -specialists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is important to ensure equity of access to treatment?. ### Response: raise awareness of iron -deficiency in HF amongst non -specialists.


Instruction: Why could the committee only consider a recommendation?

Output: if there was robust evidence of both clinical and cost effectiveness of treating identified iron deficiency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why could the committee only consider a recommendation?. ### Response: if there was robust evidence of both clinical and cost effectiveness of treating identified iron deficiency.


Instruction: What could the committee only consider if there was robust evidence of both clinical and cost effectiveness of treating iron deficiency?

Output: a recommendation that all people with HF be tested

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could the committee only consider if there was robust evidence of both clinical and cost effectiveness of treating iron deficiency?. ### Response: a recommendation that all people with HF be tested.


Instruction: What did the committee feel could not be considered?

Output: recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee feel could not be considered?. ### Response: recommendations.


Instruction: What did the committee feel could be changed in the future?

Output: when further evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee feel could be changed in the future?. ### Response: when further evidence.


Instruction: What was largely ineffective and poorly tolerated?

Output: oral iron

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was largely ineffective and poorly tolerated?. ### Response: oral iron.


Instruction: Who offered oral iron in clinical practice?

Output: their GP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who offered oral iron in clinical practice?. ### Response: their GP.


Instruction: Who sometimes offered oral iron in clinical practice?

Output: their GP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who sometimes offered oral iron in clinical practice?. ### Response: their GP.


Instruction: What did the IRONOUT -HF study show did not have a clinical benefit in people with HFREF and iron deficiency?

Output: oral iron

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the IRONOUT -HF study show did not have a clinical benefit in people with HFREF and iron deficiency?. ### Response: oral iron.


Instruction: What did the committee consider the different regimens of IV iron in various trials and in real-life situations?

Output: multiple long infusions to shorter injections

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee consider the different regimens of IV iron in various trials and in real-life situations?. ### Response: multiple long infusions to shorter injections.


Instruction: What practice tends to be moving from multiple long infusions to shorter injections to replace iron more quickly?

Output: large infusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What practice tends to be moving from multiple long infusions to shorter injections to replace iron more quickly?. ### Response: large infusion.


Instruction: The committee expressed a preference for what type of infusion?

Output: large

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committee expressed a preference for what type of infusion?. ### Response: large.


Instruction: What did the reps feel would quickly improve their quality of life?

Output: large infusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the reps feel would quickly improve their quality of life?. ### Response: large infusion.


Instruction: What was the consensus that we should be moving towards?

Output: a separate pathway for iron deficiency in HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the consensus that we should be moving towards?. ### Response: a separate pathway for iron deficiency in HF.


Instruction: What pathway for iron deficiency in HF is similar to the pathway for anaemia in CKD?

Output: a separate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What pathway for iron deficiency in HF is similar to the pathway for anaemia in CKD?. ### Response: a separate.


Instruction: The committee considered that a general recommendation would be what?

Output: a change in practi ce with an impact from both t esting and treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committee considered that a general recommendation would be what?. ### Response: a change in practi ce with an impact from both t esting and treatment.


Instruction: What did the committee feel should be revisited when further evidence was published in the future?

Output: a change in practi ce with an impact from both t esting and treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee feel should be revisited when further evidence was published in the future?. ### Response: a change in practi ce with an impact from both t esting and treatment.


Instruction: The committee was aware of the currently active IRONMAN trial.

Output: https://clinical trials.gov/ct2/show

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committee was aware of the currently active IRONMAN trial.. ### Response: https://clinical trials.gov/ct2/show.


Instruction: Who funded the IRONMAN trial?

Output: British Heart Foundation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who funded the IRONMAN trial?. ### Response: British Heart Foundation.


Instruction: What did the committee think would be useful to find out about the effect of iron replacement?

Output: high quality evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee think would be useful to find out about the effect of iron replacement?. ### Response: high quality evidence.


Instruction: Who is the sponsor of the trial that is currently active?

Output: British Heart Foundation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the sponsor of the trial that is currently active?. ### Response: British Heart Foundation.


Instruction: What mechanism was offered to replace iron?

Output: shorter injections

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What mechanism was offered to replace iron?. ### Response: shorter injections.


Instruction: What did the committee note that the trials only included?

Output: people with reduced

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee note that the trials only included?. ### Response: people with reduced.


Instruction: What is enoxaparin vs unfrac-tionated heparin used for in high-risk patients with non-ST-segment elevationacute coronary syndromes managed with an intended early invasivestrategy?

Output: elective percutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is enoxaparin vs unfrac-tionated heparin used for in high-risk patients with non-ST-segment elevationacute coronary syndromes managed with an intended early invasivestrategy?. ### Response: elective percutaneous coronary intervention.


Instruction: What was the primary outcome of the SYNERGY randomized trial?

Output: Enoxaparin vs unfrac-tionated heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary outcome of the SYNERGY randomized trial?. ### Response: Enoxaparin vs unfrac-tionated heparin.


Instruction: When was the JAMA published?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the JAMA published?. ### Response: 2004.


Instruction: How long did the STEEPLE trial last?

Output: 1-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the STEEPLE trial last?. ### Response: 1-year.


Instruction: What is enoxaparin versus unfractionated heparin?

Output: Enoxaparin versus unfrac-tionated heparin in elective percutaneous coronary intervention 1-yearresults from the STEEPLE (SafeTy and efficacy of enoxaparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is enoxaparin versus unfractionated heparin?. ### Response: Enoxaparin versus unfrac-tionated heparin in elective percutaneous coronary intervention 1-yearresults from the STEEPLE (SafeTy and efficacy of enoxaparin.


Instruction: What is the efficacy of enoxaparin in per-cutaneous coronary intervention patients, an international randomizedevaluation) trial?

Output: STEEPLE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the efficacy of enoxaparin in per-cutaneous coronary intervention patients, an international randomizedevaluation) trial?. ### Response: STEEPLE.


Instruction: What is the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al 2020 ACC/AHA Guideline for the Management of Valvular Heart DiseaseFebruary 2, 2021 Circulation. 2021;143:e72–e227

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al 2020 ACC/AHA Guideline for the Management of Valvular Heart DiseaseFebruary 2, 2021 Circulation. 2021;143:e72–e227.


Instruction: What is available online?

Output: comprehensive disclosure infor -mation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is available online?. ### Response: comprehensive disclosure infor -mation.


Instruction: Where is comprehensive disclosure information for the Joint Committee?

Output: online

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is comprehensive disclosure information for the Joint Committee?. ### Response: online.


Instruction: Where is the commit-tee also available?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the commit-tee also available?. ### Response: https://www.acc.org.


Instruction: What does the writing com-mitee use in developing recommendations?

Output: systematic re-view

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the writing com-mitee use in developing recommendations?. ### Response: systematic re-view.


Instruction: What is commissioned when there are one or more questions of utmost clinical importance that merit for -mal systematic review?

Output: An independent evidence review committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is commissioned when there are one or more questions of utmost clinical importance that merit for -mal systematic review?. ### Response: An independent evidence review committee.


Instruction: To determine which patients are most likely to benefit from a drug, device, or treatment strategy?

Output: the reader should confirm dosage with product insert material and evaluate for contraindica-tions and interactions. Recommendations are limited to drugs, devices, and treatments approved for clinical use in the United States

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: To determine which patients are most likely to benefit from a drug, device, or treatment strategy?. ### Response: the reader should confirm dosage with product insert material and evaluate for contraindica-tions and interactions. Recommendations are limited to drugs, devices, and treatments approved for clinical use in the United States.


Instruction: What is a criteria for commissioning an evidence review committee and formal systematic review?

Output: absence of a current authoritative systematic review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a criteria for commissioning an evidence review committee and formal systematic review?. ### Response: absence of a current authoritative systematic review.


Instruction: How many patients are likely to benefit from an evidence review?

Output: relevance to a substantial number

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients are likely to benefit from an evidence review?. ### Response: relevance to a substantial number.


Instruction: Who may be a member of the evidence review committee?

Output: methodologists, epidemiologists, clinicians, and bio-statisticians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who may be a member of the evidence review committee?. ### Response: methodologists, epidemiologists, clinicians, and bio-statisticians.


Instruction: What are some of the committee members?

Output: methodologists, epidemiologists, clinicians, and bio-statisticians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the committee members?. ### Response: methodologists, epidemiologists, clinicians, and bio-statisticians.


Instruction: What is the term for guideline-directed management and therapy?

Output: GDMT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for guideline-directed management and therapy?. ### Response: GDMT.


Instruction: What is GDMT?

Output: guideline-directed management and therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is GDMT?. ### Response: guideline-directed management and therapy.


Instruction: What are pharmacological and procedural treatments?

Output: Guideline-Directed Management and Therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are pharmacological and procedural treatments?. ### Response: Guideline-Directed Management and Therapy.


Instruction: What should the reader confirm with product insert material and evaluate for?

Output: contraindica-tions and interactions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should the reader confirm with product insert material and evaluate for?. ### Response: contraindica-tions and interactions.


Instruction: Where are recommendations limited?

Output: drugs, devices, and treatments approved for clinical use in the United States

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are recommendations limited?. ### Response: drugs, devices, and treatments approved for clinical use in the United States.


Instruction: Who was the head of the Joint Committee on Clinical Practice Guidelines?

Output: Patrick T. O’Gara

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the head of the Joint Committee on Clinical Practice Guidelines?. ### Response: Patrick T. O’Gara.


Instruction: What is the name of the committee that reviewed literature published through March 1, 2020?

Output: evidence review committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the committee that reviewed literature published through March 1, 2020?. ### Response: evidence review committee.


Instruction: Who is the chairman of the ACC/AHA Joint Committee?

Output: Patrick T. O’Gara

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the chairman of the ACC/AHA Joint Committee?. ### Response: Patrick T. O’Gara.


Instruction: When did searches extend to studies, reviews, and other evidence involving human subjects?

Output: March 1, 2020

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did searches extend to studies, reviews, and other evidence involving human subjects?. ### Response: March 1, 2020.


Instruction: What databases were indexed in PubMed?

Output: EMBASE, Cochrane, Agency for Healthcare Research and Quality Reports

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What databases were indexed in PubMed?. ### Response: EMBASE, Cochrane, Agency for Healthcare Research and Quality Reports.


Instruction: What is a marker of decongestion, dyspnea relief, and clinical outcomes among patients hospitalized with acute heart failure?

Output: C-reactive protein

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a marker of decongestion, dyspnea relief, and clinical outcomes among patients hospitalized with acute heart failure?. ### Response: C-reactive protein.


Instruction: What does NT-ProBNP reduction predict during hospital stay?

Output: long-term mortality and readmission

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does NT-ProBNP reduction predict during hospital stay?. ### Response: long-term mortality and readmission.


Instruction: What predicts long-term mortality and readmission in heart failure patients?

Output: NT-ProBNP reduction percent-age during hospital stay

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What predicts long-term mortality and readmission in heart failure patients?. ### Response: NT-ProBNP reduction percent-age during hospital stay.


Instruction: What is NT-ProBNP reduction percentage during admission for acute decompensated heart failure?

Output: long-term cardiovascular mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NT-ProBNP reduction percentage during admission for acute decompensated heart failure?. ### Response: long-term cardiovascular mortality.


Instruction: What is a predictor of improvement and readmission in heart failure?

Output: C-reactive protein

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a predictor of improvement and readmission in heart failure?. ### Response: C-reactive protein.


Instruction: What is the prognostic value of estab-lished and novel biomarkers in patients?

Output: galec-tin-3, a novel marker of fibrosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the prognostic value of estab-lished and novel biomarkers in patients?. ### Response: galec-tin-3, a novel marker of fibrosis.


Instruction: What does PRIDE stand for?

Output: Pro-Brain Natriuretic Peptide Investigation of Dyspnea in the Emergency Department

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does PRIDE stand for?. ### Response: Pro-Brain Natriuretic Peptide Investigation of Dyspnea in the Emergency Department.


Instruction: What is the name of the program used to measure the inter -leukin family member ST2?

Output: International ST2 Consensus Panel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the program used to measure the inter -leukin family member ST2?. ### Response: International ST2 Consensus Panel.


Instruction: What is PRIDE?

Output: Pro-Brain Natriuretic Peptide Investigation of Dyspnea in the Emergency Department

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PRIDE?. ### Response: Pro-Brain Natriuretic Peptide Investigation of Dyspnea in the Emergency Department.


Instruction: When was the PRIDE study conducted?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the PRIDE study conducted?. ### Response: 2007.


Instruction: What is ST2 a predictor of in patients with heart failure relative to?

Output: left ventricular ejection fraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ST2 a predictor of in patients with heart failure relative to?. ### Response: left ventricular ejection fraction.


Instruction: What was the 2011 Am J Cardiol. 107:259-67?

Output: Usefulness of soluble concentrations of interleukin family member ST2 as predictor of mortality in patients with acutely decompensated heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 2011 Am J Cardiol. 107:259-67?. ### Response: Usefulness of soluble concentrations of interleukin family member ST2 as predictor of mortality in patients with acutely decompensated heart failure.


Instruction: What is Galectin-3 called in patients with heart failure?

Output: galec-tin-3, a novel marker of fibrosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Galectin-3 called in patients with heart failure?. ### Response: galec-tin-3, a novel marker of fibrosis.


Instruction: What is the name of the drug that affects cardiac struc-ture and function?

Output: Galectin-3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug that affects cardiac struc-ture and function?. ### Response: Galectin-3.


Instruction: In what year did Eur J Heart Fail issue 12:826-832?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did Eur J Heart Fail issue 12:826-832?. ### Response: 2010.


Instruction: What is a novel marker of fibrosis?

Output: galec-tin-3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a novel marker of fibrosis?. ### Response: galec-tin-3.


Instruction: What is the predictive value of plasma galectin-3 levels in heart failure with reduced and preserved ejection fraction?

Output: renal insufficiency and survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the predictive value of plasma galectin-3 levels in heart failure with reduced and preserved ejection fraction?. ### Response: renal insufficiency and survival.


Instruction: What is galec-tin-3?

Output: a novel marker of fibrosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is galec-tin-3?. ### Response: a novel marker of fibrosis.


Instruction: When did the DEAL-HF study take place?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the DEAL-HF study take place?. ### Response: 2010.


Instruction: How does galectin-3 levels predict renal insufficiency and survival?

Output: Usefulness of plasma galectin-3 levels in systolic heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does galectin-3 levels predict renal insufficiency and survival?. ### Response: Usefulness of plasma galectin-3 levels in systolic heart failure.


Instruction: What predicts renal insufficiency and survival?

Output: Usefulness of plasma galectin-3 levels in systolic heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What predicts renal insufficiency and survival?. ### Response: Usefulness of plasma galectin-3 levels in systolic heart failure.


Instruction: What is systolic heart failure used to predict?

Output: renal insufficiency and survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is systolic heart failure used to predict?. ### Response: renal insufficiency and survival.


Instruction: When did 108:385–90 appear in Am J Cardiol?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did 108:385–90 appear in Am J Cardiol?. ### Response: 2011.


Instruction: How did Tang WH, Wu Y, Grodin JL, et al. determine the prognostic value of Baseline and changes in Circulating Soluble ST2 levels?

Output: the International ST2 Consensus Panel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Tang WH, Wu Y, Grodin JL, et al. determine the prognostic value of Baseline and changes in Circulating Soluble ST2 levels?. ### Response: the International ST2 Consensus Panel.


Instruction: Decompensated heart failure. 2016;4:68–77.

Output: J Am Coll Cardiol HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Decompensated heart failure. 2016;4:68–77.. ### Response: J Am Coll Cardiol HF.


Instruction: The International ST2 Consensus Panel. 2015;115:26B–31B.

Output: Am J Cardiol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The International ST2 Consensus Panel. 2015;115:26B–31B.. ### Response: Am J Cardiol.


Instruction: What is the target for patients with CKD without diabetes based on?

Output: CV and survival bene ﬁts in the CKD sub-group in SPRINT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the target for patients with CKD without diabetes based on?. ### Response: CV and survival bene ﬁts in the CKD sub-group in SPRINT.


Instruction: What do MDRD and AASK studies also sug-gest?

Output: kidney

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do MDRD and AASK studies also sug-gest?. ### Response: kidney.


Instruction: What may be similar to thelower BP goal in SPRINT?

Output: BP levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be similar to thelower BP goal in SPRINT?. ### Response: BP levels.


Instruction: What reversed previous recom-mendations from other organizations?

Output: The KDIGO 2012 guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What reversed previous recom-mendations from other organizations?. ### Response: The KDIGO 2012 guideline.


Instruction: ACCORD-BP failed to demonstrate what?

Output: signi ﬁcant bene ﬁts for the primary CV endpoint

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ACCORD-BP failed to demonstrate what?. ### Response: signi ﬁcant bene ﬁts for the primary CV endpoint.


Instruction: What is the primary CV endpoint in the intensive BP-lowering arm?

Output: ACCORD-BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary CV endpoint in the intensive BP-lowering arm?. ### Response: ACCORD-BP.


Instruction: What have SPRINT and other analyses of ACCORD supported?

Output: intensive BP-lowering therapy might well confer similarbeneﬁts among patients with diabetes and CKD as in patientswith CKD alone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have SPRINT and other analyses of ACCORD supported?. ### Response: intensive BP-lowering therapy might well confer similarbeneﬁts among patients with diabetes and CKD as in patientswith CKD alone.


Instruction: In patients with diabetes and CKD, what might confer similarbenefits?

Output: intensive BP-lowering therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with diabetes and CKD, what might confer similarbenefits?. ### Response: intensive BP-lowering therapy.


Instruction: What is low in CKD patients with concomitant diabetes?

Output: quality of evidence for BPtarget

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is low in CKD patients with concomitant diabetes?. ### Response: quality of evidence for BPtarget.


Instruction: What is the recommendation of SBP 120 mm Hg classi fied asweak?

Output: weak recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommendation of SBP 120 mm Hg classi fied asweak?. ### Response: weak recommendations.