Instruction: What is a Metabolic Syndrome S9.7-1?

Output: Pharmacological treatment and therapeutic perspectives of metabolic syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a Metabolic Syndrome S9.7-1?. ### Response: Pharmacological treatment and therapeutic perspectives of metabolic syndrome.


Instruction: How is ALLHAT found-ings revisited in the context of subsequent analyses?

Output: other trials, and meta-analyses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is ALLHAT found-ings revisited in the context of subsequent analyses?. ### Response: other trials, and meta-analyses.


Instruction: What is the name of the journal that deals with the treatment of metabolic syndrome?

Output: Lancet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that deals with the treatment of metabolic syndrome?. ### Response: Lancet.


Instruction: What are the names of the journals that deal with the metabolic syndrome and obesity?

Output: evi-dence, meta-analysis, post hoc and guidelines publications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the journals that deal with the metabolic syndrome and obesity?. ### Response: evi-dence, meta-analysis, post hoc and guidelines publications.


Instruction: Who is the author of the review of the literature on anti-hypertensive drug treatment?

Output: Owen JG, Reisin E

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of the review of the literature on anti-hypertensive drug treatment?. ### Response: Owen JG, Reisin E.


Instruction: How many pages are in the Curr Hypertens Rep?

Output: 16:410

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many pages are in the Curr Hypertens Rep?. ### Response: 16:410.


Instruction: What is a metabolic syndrome?

Output: chronic kidney disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a metabolic syndrome?. ### Response: chronic kidney disease.


Instruction: Who wrote Endocrinology: Adult & Pediatric?

Output: Jameson JL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote Endocrinology: Adult & Pediatric?. ### Response: Jameson JL.


Instruction: What is the name of the organization that publishes the study?

Output: Elsevier Saunders

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that publishes the study?. ### Response: Elsevier Saunders.


Instruction: How long did it take to increase the prevalence of Metabolic Syndrome?

Output: 1999–2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take to increase the prevalence of Metabolic Syndrome?. ### Response: 1999–2006.


Instruction: NHANES 1999-2006. Diabetes Care. 2011;34:216-9. S9.7-5. Chen J, Muntner P, Hamm LL, et al. The metabolic syndrome and chronic kidney disease in U.S. adults. Ann Intern Med. 2004;140:167–74.

Output: NHANES III

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: NHANES 1999-2006. Diabetes Care. 2011;34:216-9. S9.7-5. Chen J, Muntner P, Hamm LL, et al. The metabolic syndrome and chronic kidney disease in U.S. adults. Ann Intern Med. 2004;140:167–74.. ### Response: NHANES III.


Instruction: What is metabolic syndrome and chronic kidney disease in Chinese adults?

Output: Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is metabolic syndrome and chronic kidney disease in Chinese adults?. ### Response: Association.


Instruction: What is the glycemic effects of anti-hypertensive medications?

Output: 410. S9.7-8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the glycemic effects of anti-hypertensive medications?. ### Response: 410. S9.7-8.


Instruction: How long does diuretic-based therapy last?

Output: Long-term effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does diuretic-based therapy last?. ### Response: Long-term effect.


Instruction: What is the effect of diuretic-based therapy on fatal outcomes in isolated systolic hypertension with and without diabetes?

Output: Long-term effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of diuretic-based therapy on fatal outcomes in isolated systolic hypertension with and without diabetes?. ### Response: Long-term effect.


Instruction: What did Wright JT Jr, Harris-Haywood S, Pressel S, et al. study?

Output: Clinical outcomes by race in hypertensive patients with and without the metabolic syn-drome: Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Wright JT Jr, Harris-Haywood S, Pressel S, et al. study?. ### Response: Clinical outcomes by race in hypertensive patients with and without the metabolic syn-drome: Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial.


Instruction: What is the acronym for the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial?

Output: ALLHAT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial?. ### Response: ALLHAT.


Instruction: What year did the Arch Intern Med publish the results of the ALLHAT trial?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did the Arch Intern Med publish the results of the ALLHAT trial?. ### Response: 2008.


Instruction: What is the name of the journal that studies metabolic syndrome?

Output: Arch Intern Med.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies metabolic syndrome?. ### Response: Arch Intern Med..


Instruction: What are the names of the journals that study metabolic syndrome in nondiabetic individuals?

Output: Arch Intern Med.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the journals that study metabolic syndrome in nondiabetic individuals?. ### Response: Arch Intern Med..


Instruction: What is a Rotational coronaryatherectomy after unsuccessful coronary balloon angioplasty?

Output: stentablation) in a lesion with stent underexpansion due to heavilycalcified plaque

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a Rotational coronaryatherectomy after unsuccessful coronary balloon angioplasty?. ### Response: stentablation) in a lesion with stent underexpansion due to heavilycalcified plaque.


Instruction: What is the term for rotational atherectomy in a lesion with stent underexpansion due to heavilycalcified plaque?

Output: stentablation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for rotational atherectomy in a lesion with stent underexpansion due to heavilycalcified plaque?. ### Response: stentablation.


Instruction: Catheter Cardiovasc Interv. 2001;52:208–11.522.

Output: Rotational atherectomy(stentablation) in a lesion with stent underexpansion due to heavilycalcified plaque

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Catheter Cardiovasc Interv. 2001;52:208–11.522.. ### Response: Rotational atherectomy(stentablation) in a lesion with stent underexpansion due to heavilycalcified plaque.


Instruction: What improves myo-cardial reperfusion and reduces infarct size?

Output: Thrombus aspirationduring primary percutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What improves myo-cardial reperfusion and reduces infarct size?. ### Response: Thrombus aspirationduring primary percutaneous coronary intervention.


Instruction: What is the EXPIRA?

Output: throm-bectomy with export catheter in infarct-related artery during primarypercutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the EXPIRA?. ### Response: throm-bectomy with export catheter in infarct-related artery during primarypercutaneous coronary intervention.


Instruction: What is the name of the study that followed a 1 year follow-up?

Output: Percutaneouscoronary intervention in Acute myocardial infarction Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that followed a 1 year follow-up?. ### Response: Percutaneouscoronary intervention in Acute myocardial infarction Study.


Instruction: When did the TAPAS study begin?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the TAPAS study begin?. ### Response: 2008.


Instruction: How long did it take for a patient to recover from thrombosis and reinfarction?

Output: 1 year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for a patient to recover from thrombosis and reinfarction?. ### Response: 1 year.


Instruction: What is the role of thrombectomy and embolic protection devices in acute myocardial infarction?

Output: adjunctive

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of thrombectomy and embolic protection devices in acute myocardial infarction?. ### Response: adjunctive.


Instruction: When was the Eur Heart J.29:2989–3001.525 published?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Eur Heart J.29:2989–3001.525 published?. ### Response: 2008.


Instruction: What was the effect of percutaneouscoronary intervention on infarct size reduction?

Output: improves myo-cardial reperfusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the effect of percutaneouscoronary intervention on infarct size reduction?. ### Response: improves myo-cardial reperfusion.


Instruction: Infarct size reduction in acute myocardialinfarction: 30-day results from a multicenter randomized study?

Output: Rheolytic thrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Infarct size reduction in acute myocardialinfarction: 30-day results from a multicenter randomized study?. ### Response: Rheolytic thrombectomy.


Instruction: What is the name of the trial that compares AngioJetrheolytic thrombectomy with direct stenting alone?

Output: EXPIRA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the trial that compares AngioJetrheolytic thrombectomy with direct stenting alone?. ### Response: EXPIRA.


Instruction: What is the name of the trial to treat acute myocardial infarction?

Output: EXPIRA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the trial to treat acute myocardial infarction?. ### Response: EXPIRA.


Instruction: When did the JETSTENT trial begin?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the JETSTENT trial begin?. ### Response: 2010.


Instruction: What is a potential benefit of using a high energy excimer laser?

Output: treat coronaryin-stent restenosis in an underexpanded stent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a potential benefit of using a high energy excimer laser?. ### Response: treat coronaryin-stent restenosis in an underexpanded stent.


Instruction: What is LAVA?

Output: Laser AngioplastyVersus Angioplasty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is LAVA?. ### Response: Laser AngioplastyVersus Angioplasty.


Instruction: What type of angioplasty is used in patients with obstructivecoronary artery disease?

Output: stand-alone balloon

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of angioplasty is used in patients with obstructivecoronary artery disease?. ### Response: stand-alone balloon.


Instruction: When was the J Am Coll Cardiol 30:1714–21.529?

Output: 1997

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol 30:1714–21.529?. ### Response: 1997.


Instruction: What is the name of the trial that evaluated balloon angioplasty for the treatment of in-stent restenosis?

Output: RESCUT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the trial that evaluated balloon angioplasty for the treatment of in-stent restenosis?. ### Response: RESCUT.


Instruction: When was the restnosis cutting balloon evaluation trial conducted?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the restnosis cutting balloon evaluation trial conducted?. ### Response: 2004.


Instruction: What was the result of the cutting balloon global ran-domized trial?

Output: Cutting balloon angioplasty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the result of the cutting balloon global ran-domized trial?. ### Response: Cutting balloon angioplasty.


Instruction: What year was the Global Ran-domized Trial published?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the Global Ran-domized Trial published?. ### Response: 2002.


Instruction: What was the name of the nonrandomized com-parison of coronary stenting under intravascular ultrasound guidance?

Output: de Ribamar CJ Jr, Mintz GS, Carlier SG, et al. Nonrandomized com-parison of coronary stenting under intravascular ultrasound guidance ofdirect stenting without predilation versus conventional predilation witha semi-compliant balloon versus predilation with a new scoring balloon

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the nonrandomized com-parison of coronary stenting under intravascular ultrasound guidance?. ### Response: de Ribamar CJ Jr, Mintz GS, Carlier SG, et al. Nonrandomized com-parison of coronary stenting under intravascular ultrasound guidance ofdirect stenting without predilation versus conventional predilation witha semi-compliant balloon versus predilation with a new scoring balloon.


Instruction: What is the acronym for the incremental cost -effectiveness ratio?

Output: ICER

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the incremental cost -effectiveness ratio?. ### Response: ICER.


Instruction: What is ICER?

Output: Incremental cost -effectiveness ratio

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ICER?. ### Response: Incremental cost -effectiveness ratio.


Instruction: What is the ICER?

Output: Incremental cost -effectiveness ratio

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ICER?. ### Response: Incremental cost -effectiveness ratio.


Instruction: How much is the incremental cost divided by the incremental effect s?

Output: £ per QALY gained

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much is the incremental cost divided by the incremental effect s?. ### Response: £ per QALY gained.


Instruction: What is a summary of the extent of uncertainty?

Output: ICER reflecting the results of deterministic or probabilistic sensitivity analyses, or stochastic analyses of trial data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a summary of the extent of uncertainty?. ### Response: ICER reflecting the results of deterministic or probabilistic sensitivity analyses, or stochastic analyses of trial data.


Instruction: What was the economic evaluation checklist in appendix H of the NICE guidelines manual used for?

Output: Applicability and lim itations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the economic evaluation checklist in appendix H of the NICE guidelines manual used for?. ### Response: Applicability and lim itations.


Instruction: What did NICE use to assess the applicability and lim itations of trial data?

Output: economic evaluation checklist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did NICE use to assess the applicability and lim itations of trial data?. ### Response: economic evaluation checklist.


Instruction: Who reviewed the publi shed health economic literature for each review question?

Output: health economist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who reviewed the publi shed health economic literature for each review question?. ### Response: health economist.


Instruction: Who did the health economist undertake new health economic analysis in selected areas?

Output: reviewing the publi shed health economic literature for each review question

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who did the health economist undertake new health economic analysis in selected areas?. ### Response: reviewing the publi shed health economic literature for each review question.


Instruction: What was agreed by the committee after formation of the review questions?

Output: Priority areas for new analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was agreed by the committee after formation of the review questions?. ### Response: Priority areas for new analysis.


Instruction: What was identified as the highest priority area for original health economic modelling?

Output: natriuretic peptide threshold for referral for echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was identified as the highest priority area for original health economic modelling?. ### Response: natriuretic peptide threshold for referral for echocardiography.


Instruction: What was the committee concerned about?

Output: natriuretic peptide thresholds may be too high, resulting in delayed diagnosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the committee concerned about?. ### Response: natriuretic peptide thresholds may be too high, resulting in delayed diagnosis.


Instruction: Why did the committee identify determining a natriuretic peptide threshold?

Output: concerns that the current natriuretic peptide thresholds may be too high, resulting in delayed diagnosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why did the committee identify determining a natriuretic peptide threshold?. ### Response: concerns that the current natriuretic peptide thresholds may be too high, resulting in delayed diagnosis.


Instruction: What was the reason for the economic modelling of natriuretic peptide thresholds?

Output: concerns that the current natriuretic peptide thresholds may be too high

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the reason for the economic modelling of natriuretic peptide thresholds?. ### Response: concerns that the current natriuretic peptide thresholds may be too high.


Instruction: What could be a significant increase in cost if the threshold was lowered?

Output: more patients were referred for e chocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could be a significant increase in cost if the threshold was lowered?. ### Response: more patients were referred for e chocardiography.


Instruction: How many patients were referred for e chocardiography?

Output: more

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were referred for e chocardiography?. ### Response: more.


Instruction: What general principles were adhered to in developing the cost -effectiveness analysis?

Output: Methods were consistent with the NICE reference case  for interventions with health outcomes in NHS settings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What general principles were adhered to in developing the cost -effectiveness analysis?. ### Response: Methods were consistent with the NICE reference case  for interventions with health outcomes in NHS settings.


Instruction: Who was involved in the design of the model, selection of inputs and interpretation of the results?

Output: The comm ittee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was involved in the design of the model, selection of inputs and interpretation of the results?. ### Response: The comm ittee.


Instruction: The model inputs were based on the systematic review of what literature?

Output: clinical literature

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The model inputs were based on the systematic review of what literature?. ### Response: clinical literature.


Instruction: What was used to populate the model when published data were not available?

Output: committee  expert opinion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was used to populate the model when published data were not available?. ### Response: committee  expert opinion.


Instruction: What was reported fully and transparently?

Output: Model inputs and assumptions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was reported fully and transparently?. ### Response: Model inputs and assumptions.


Instruction: The results were subject to what analysis?

Output: sensitivity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The results were subject to what analysis?. ### Response: sensitivity.


Instruction: What was subject to sensitivity analysis and limitations were discussed?

Output: The results

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was subject to sensitivity analysis and limitations were discussed?. ### Response: The results.


Instruction: What was peer -reviewed by another health economist at the NGC?

Output: The model

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was peer -reviewed by another health economist at the NGC?. ### Response: The model.


Instruction: What is NICE's report on social value judgements?

Output: principles for the development of NICE guidance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE's report on social value judgements?. ### Response: principles for the development of NICE guidance.


Instruction: What are the full methods for the cost -effectiveness analysis of?

Output: natriuretic peptide thresholds

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the full methods for the cost -effectiveness analysis of?. ### Response: natriuretic peptide thresholds.


Instruction: What does the report 'Social value judgements: principles for the development of NICE guidance' outline?

Output: the principles tha t committee s should consider when judging whether an intervention offers good value

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the report 'Social value judgements: principles for the development of NICE guidance' outline?. ### Response: the principles tha t committee s should consider when judging whether an intervention offers good value.


Instruction: What should committees consider when judging whether an intervention offers good value?

Output: selection of inputs and interpretation of the results.   Model inputs were based on the systematic review of the clinical literature supplemented with other published data sources where possible.   When published data were  not available committee  expert opinion was used to populate the model.   Model inputs and assumptions were reported fully and transparently.   The results were subject to sensitivity analysis and limitations were discussed.   The model was peer -reviewe d by another health economist at the NGC . The model methods were also peer -reviewed by Professor Martin Cowie because of his expertise in heart failure, knowledge of the literature and health economic  modelling methodologies .  Full methods for the cost -effectiveness analysis of natriuretic peptide thresholds  are described in appendix  O. 4.4.3 Cost -effectiveness criteria  NICE’s report ‘Social value judgements: principles for the development of NICE guidance’ sets out the principles

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should committees consider when judging whether an intervention offers good value?. ### Response: selection of inputs and interpretation of the results.   Model inputs were based on the systematic review of the clinical literature supplemented with other published data sources where possible.   When published data were  not available committee  expert opinion was used to populate the model.   Model inputs and assumptions were reported fully and transparently.   The results were subject to sensitivity analysis and limitations were discussed.   The model was peer -reviewe d by another health economist at the NGC . The model methods were also peer -reviewed by Professor Martin Cowie because of his expertise in heart failure, knowledge of the literature and health economic  modelling methodologies .  Full methods for the cost -effectiveness analysis of natriuretic peptide thresholds  are described in appendix  O. 4.4.3 Cost -effectiveness criteria  NICE’s report ‘Social value judgements: principles for the development of NICE guidance’ sets out the principles.


Instruction: What is the date of the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction?

Output: June 2020

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the date of the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction?. ### Response: June 2020.


Instruction: What is the name of the non-pharmacologic treatment that includes cost?

Output: costly

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the non-pharmacologic treatment that includes cost?. ### Response: costly.


Instruction: What is another name for combine sets without outcomes of interest?

Output: AND (#3 OR #4 OR #5)  #9 Limit to RCTs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for combine sets without outcomes of interest?. ### Response: AND (#3 OR #4 OR #5)  #9 Limit to RCTs.


Instruction: How many RCTs are there?

Output: 18

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs are there?. ### Response: 18.


Instruction: What is the limit to SRs/Meta -analysis Systematic review/meta-analysis hedge?

Output: #10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the limit to SRs/Meta -analysis Systematic review/meta-analysis hedge?. ### Response: #10.


Instruction: What is a limit to cost studies (KQ 9)?

Output: #11

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a limit to cost studies (KQ 9)?. ### Response: #11.


Instruction: What is an example of a cost effectiveness analysis?

Output: health care cost

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a cost effectiveness analysis?. ### Response: health care cost.


Instruction: What is a quality adjusted life year?

Output: exp OR (cost OR costs OR costly OR costing OR price OR prices OR saving OR savings OR economi* OR financial OR finance* OR pharmacoeconomic* OR QALY or QALYs OR (quality NEXT/1 adjusted

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a quality adjusted life year?. ### Response: exp OR (cost OR costs OR costly OR costing OR price OR prices OR saving OR savings OR economi* OR financial OR finance* OR pharmacoeconomic* OR QALY or QALYs OR (quality NEXT/1 adjusted.


Instruction: What is the name of the QALY?

Output: QALYs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the QALY?. ### Response: QALYs.


Instruction: How many Combine sets are there?

Output: #8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many Combine sets are there?. ### Response: #8.


Instruction: What are the names of the Combine sets?

Output: #7 AND (#9 OR #10)  #13

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the Combine sets?. ### Response: #7 AND (#9 OR #10)  #13.


Instruction: How many Search Limits have been applied to humans and items published since 2014?

Output: 18

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many Search Limits have been applied to humans and items published since 2014?. ### Response: 18.


Instruction: When were searches conducted for 2014 CPG?

Output: December 9, 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When were searches conducted for 2014 CPG?. ### Response: December 9, 2013.


Instruction: What language does CPG use?

Output: english

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What language does CPG use?. ### Response: english.


Instruction: What language is CPG used for?

Output: english

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What language is CPG used for?. ### Response: english.


Instruction: How many pages are allowed to be in CPG?

Output: 18

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many pages are allowed to be in CPG?. ### Response: 18.


Instruction: What does book.pt. OR letter/ or editorial/ or news/ or comment/ or case report or case reports/ or note/ or conference paper/ or (letter or editorial or news or comment) or conference abstract* or (child* or teen* or school* or baby or babies or infant* or neonat* or nursery* or newborn* or what else?

Output: dt

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does book.pt. OR letter/ or editorial/ or news/ or comment/ or case report or case reports/ or note/ or conference paper/ or (letter or editorial or news or comment) or conference abstract* or (child* or teen* or school* or baby or babies or infant* or neonat* or nursery* or newborn* or what else?. ### Response: dt.


Instruction: What is the limit to meta -analyses and SRs AND?

Output: 18

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the limit to meta -analyses and SRs AND?. ### Response: 18.


Instruction: What are RCTs or Randomized controlled trials or random allocation or double blind trials?

Output: Randomized controlled trials or random allocation or double -blind method or single -blind method or placebos or cross -over studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are RCTs or Randomized controlled trials or random allocation or double blind trials?. ### Response: Randomized controlled trials or random allocation or double -blind method or single -blind method or placebos or cross -over studies.


Instruction: Randomized controlled trials or random allocation or double -blind method or what?

Output: single -blind method or placebos or cross -over studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Randomized controlled trials or random allocation or double -blind method or what?. ### Response: single -blind method or placebos or cross -over studies.


Instruction: What is another term for blind* or mask* or sham?

Output: ADJ3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for blind* or mask* or sham?. ### Response: ADJ3.


Instruction: ADJ3 (blind* or mask* or sham*)).mp. or ISRTCN or ACTRN* or (NCT* not NCT)?

Output: ((singl* or doubl* or tripl* or trebl*)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ADJ3 (blind* or mask* or sham*)).mp. or ISRTCN or ACTRN* or (NCT* not NCT)?. ### Response: ((singl* or doubl* or tripl* or trebl*).


Instruction: What is t he rationale and impact section on blood pressur e contr ol for people wit h acut e intracer ebral haemorrhage?

Output: committ ee made t he 2022 r ecommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is t he rationale and impact section on blood pressur e contr ol for people wit h acut e intracer ebral haemorrhage?. ### Response: committ ee made t he 2022 r ecommendations.


Instruction: In people with h acut e intracer ebral haemorrhage, what is the blood pr essur e in?

Output: lower

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In people with h acut e intracer ebral haemorrhage, what is the blood pr essur e in?. ### Response: lower.


Instruction: What are intensiv e interventions t o lower?

Output: blood pr essur e

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are intensiv e interventions t o lower?. ### Response: blood pr essur e.


Instruction: What is h acut e intracer ebral haemorrhage?

Output: lower blood pr essur e

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is h acut e intracer ebral haemorrhage?. ### Response: lower blood pr essur e.


Instruction: What is blood pr essur e control for pe ople wi th acu te ischaemic str oke 1.5.9 Anti-h yper tensiv e treatment recommended only if t here is what?

Output: a h yper tensiv e emer gency wit h one  or more of t he following serious concomitant medical issues

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is blood pr essur e control for pe ople wi th acu te ischaemic str oke 1.5.9 Anti-h yper tensiv e treatment recommended only if t here is what?. ### Response: a h yper tensiv e emer gency wit h one  or more of t he following serious concomitant medical issues.


Instruction: What if t he following serious concomitant medical issues?

Output: Anti-h yper tensiv e treatment in people wit h acut e ischaemic str oke is recommended only if t here is a h yper tensiv e emer gency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What if t he following serious concomitant medical issues?. ### Response: Anti-h yper tensiv e treatment in people wit h acut e ischaemic str oke is recommended only if t here is a h yper tensiv e emer gency.


Instruction: What is hyper tensiv e encephalopat hy?

Output: nephr opat hy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hyper tensiv e encephalopat hy?. ### Response: nephr opat hy.


Instruction: What should be considered in people who ar e candidat es for intra venous t hrombolysis?

Output: Blood pr essur e reduction t o 185/110  mmHg or lo wer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered in people who ar e candidat es for intra venous t hrombolysis?. ### Response: Blood pr essur e reduction t o 185/110  mmHg or lo wer.


Instruction: What is a car diac f ailure/myocardial inf arction?

Output: hyper tensiv

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a car diac f ailure/myocardial inf arction?. ### Response: hyper tensiv.


Instruction: What are candidates for intra venous t hrombolysis?

Output: Blood pr essur e reduction t o 185/110  mmHg or lo wer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are candidates for intra venous t hrombolysis?. ### Response: Blood pr essur e reduction t o 185/110  mmHg or lo wer.


Instruction: What do people with acut e stroke have their swallo wing screened by before being giv ed?

Output: appr opriat ely trained healt hcare professional

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do people with acut e stroke have their swallo wing screened by before being giv ed?. ### Response: appr opriat ely trained healt hcare professional.


Instruction: Who is trained before being giv en an y oral f ood, fluid or medication?

Output: healt hcare professional

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is trained before being giv en an y oral f ood, fluid or medication?. ### Response: healt hcare professional.


Instruction: 1.6.2 If the admission scr een indicat es pr oblems wit h swallo wing, ensur e that Stroke and transient ischaemic attack in o ver 16s: diagnosis and initial management(NG128)?

Output: fluid or medication

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: 1.6.2 If the admission scr een indicat es pr oblems wit h swallo wing, ensur e that Stroke and transient ischaemic attack in o ver 16s: diagnosis and initial management(NG128)?. ### Response: fluid or medication.


Instruction: Ischaemic attack in o ver 16s: diagnosis and initial management(NG128)?

Output: NICE 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Ischaemic attack in o ver 16s: diagnosis and initial management(NG128)?. ### Response: NICE 2023.


Instruction: What is the last updat ed 13 April 2022?

Output: Page 17of 48

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the last updat ed 13 April 2022?. ### Response: Page 17of 48.


Instruction: What should be limited to patients with less advanced disease in whom a durable repair can be accom-plished?

Output: every cardiac sur -geon who performs mitral valve procedures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be limited to patients with less advanced disease in whom a durable repair can be accom-plished?. ### Response: every cardiac sur -geon who performs mitral valve procedures.


Instruction: What is the procedure of choice for isolated severe primary MR limited to less than?

Output: Mitral valve repair

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the procedure of choice for isolated severe primary MR limited to less than?. ### Response: Mitral valve repair.


Instruction: What is inappropriate unless mitral valve repair has been attempted and was unsuccessful?

Output: mitral valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is inappropriate unless mitral valve repair has been attempted and was unsuccessful?. ### Response: mitral valve replacement.


Instruction: Surgical repair of primary MR has been remarkably successful what?

Output: ≥ 95%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Surgical repair of primary MR has been remarkably successful what?. ### Response: ≥ 95%.


Instruction: Repair of degenerative mitral disease when leaflet dys-function is a problem?

Output: annu-loplasty and repair of the posterior leaflet are necessary, has led to outcomes distinctly supe-rior to those with biological or mechanical mitral valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Repair of degenerative mitral disease when leaflet dys-function is a problem?. ### Response: annu-loplasty and repair of the posterior leaflet are necessary, has led to outcomes distinctly supe-rior to those with biological or mechanical mitral valve replacement.


Instruction: What is the operative mortality rate for repair of isolated degenerative mitral disease?

Output: <1%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the operative mortality rate for repair of isolated degenerative mitral disease?. ### Response: <1%,.


Instruction: How is repair associated with long-term survival?

Output: equivalent to that of age-matched general population

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is repair associated with long-term survival?. ### Response: equivalent to that of age-matched general population.


Instruction: What is required to repair the posterior leaflet?

Output: annu-loplasty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is required to repair the posterior leaflet?. ### Response: annu-loplasty.


Instruction: What is the operative mortality rate of 1%?

Output: <1%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the operative mortality rate of 1%?. ### Response: <1%,.


Instruction: How much free-dom from reoperation is associated with a recurrent moderate or severe MR at 15 to 20 years after surgery?

Output: >80%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much free-dom from reoperation is associated with a recurrent moderate or severe MR at 15 to 20 years after surgery?. ### Response: >80%.


Instruction: What percentage of the posterior leaflet may be reactivated after a surgical procedure?

Output: one-half

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the posterior leaflet may be reactivated after a surgical procedure?. ### Response: one-half.


Instruction: How much of the posterior leaflet may be excised, plicated, or resuspended?

Output: one-half

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the posterior leaflet may be excised, plicated, or resuspended?. ### Response: one-half.


Instruction: Posterior leaflet repair has become sufficiently standardized in what situation?

Output: resuspended

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Posterior leaflet repair has become sufficiently standardized in what situation?. ### Response: resuspended.


Instruction: What is the standard of care?

Output: Posterior leaflet repair has become sufficiently standardized in this situation so that repair, rather than mitral valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the standard of care?. ### Response: Posterior leaflet repair has become sufficiently standardized in this situation so that repair, rather than mitral valve replacement.


Instruction: What should be the expectation of every cardiac sur -geon who performs mitral valve procedures?

Output: Execution of this procedure with a success rate ≥ 95%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be the expectation of every cardiac sur -geon who performs mitral valve procedures?. ### Response: Execution of this procedure with a success rate ≥ 95%.


Instruction: What is associated with chronic secondary MR?

Output: severe LV dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with chronic secondary MR?. ### Response: severe LV dysfunction.


Instruction: What causes leaflet tethering and annular dilation?

Output: abnormal and dilated LV

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes leaflet tethering and annular dilation?. ### Response: abnormal and dilated LV.


Instruction: What causes papil-lary muscle displacement?

Output: abnormal and dilated LV

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes papil-lary muscle displacement?. ### Response: abnormal and dilated LV.


Instruction: What prevents adequate leaflet coaptation?

Output: leaflet tethering with associated annular dilation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What prevents adequate leaflet coaptation?. ### Response: leaflet tethering with associated annular dilation.


Instruction: What may also develop because of LA dilation and enlargement of the mitral annulus?

Output: Secondary MR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may also develop because of LA dilation and enlargement of the mitral annulus?. ### Response: Secondary MR.


Instruction: What is the best ther -apy for chronic secondary MR?

Output: not clear

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the best ther -apy for chronic secondary MR?. ### Response: not clear.


Instruction: What is not curative because MR is only one component of the disease?

Output: restoration of mitral valve competence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not curative because MR is only one component of the disease?. ### Response: restoration of mitral valve competence.


Instruction: The optimal criteria for defining severe secondary have been what?

Output: controversial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The optimal criteria for defining severe secondary have been what?. ### Response: controversial.


Instruction: What has been controversial for defining severe secondary MR?

Output: The optimal criteria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been controversial for defining severe secondary MR?. ### Response: The optimal criteria.


Instruction: What is associated with a smaller adverse out-comes in secondary?

Output: primary MR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with a smaller adverse out-comes in secondary?. ### Response: primary MR.


Instruction: When was this article published?

Output: April 27, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this article published?. ### Response: April 27, 2023.


Instruction: What type of diet is suggested for treatment of HTN?

Output: weight loss

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diet is suggested for treatment of HTN?. ### Response: weight loss.


Instruction: What is the VA/DoD Clinical Practice Guideline for Screening and Management of Obesity?

Output: Overweight

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for Screening and Management of Obesity?. ### Response: Overweight.


Instruction: What is the VA/DoD Clinical Practice Guideline for Screening and Management of Obesity and Overweight available at?

Output: https://www.healthquality.va.gov/guidelines/CD/obesity/ .

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for Screening and Management of Obesity and Overweight available at?. ### Response: https://www.healthquality.va.gov/guidelines/CD/obesity/ ..


Instruction: Where can you find the VA and DoD clinical practice guideline for screening and management of obesity and overweight?

Output: https://www.healthquality.va.gov/guidelines/CD/obesity/ .

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find the VA and DoD clinical practice guideline for screening and management of obesity and overweight?. ### Response: https://www.healthquality.va.gov/guidelines/CD/obesity/ ..


Instruction: Who is the principal investigator of e400 Stroke?

Output: Phillip A. Scott

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the principal investigator of e400 Stroke?. ### Response: Phillip A. Scott.


Instruction: Who is co-medical director of Clinical Trials Support Unit?

Output: University of Michigan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is co-medical director of Clinical Trials Support Unit?. ### Response: University of Michigan.


Instruction: What is Bard's job title?

Output: PI, Stroke Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Bard's job title?. ### Response: PI, Stroke Trial.


Instruction: What is the name of the PI Stroke Trial?

Output: Biogen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the PI Stroke Trial?. ### Response: Biogen.


Instruction: Who is the DSMB chair?

Output: Zoll

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the DSMB chair?. ### Response: Zoll.


Instruction: What is PHAST-TSC?

Output: Prehospital Administration of Acute Stroke Therapy with Trans-sodium Crocetinate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PHAST-TSC?. ### Response: Prehospital Administration of Acute Stroke Therapy with Trans-sodium Crocetinate.


Instruction: What is NHLBI-NINDS U01 HL088942?

Output: Cardiothoracic Surgical Trials Network

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NHLBI-NINDS U01 HL088942?. ### Response: Cardiothoracic Surgical Trials Network.


Instruction: What is the US Patent Application No. 14/910,890*?

Output: iTREAT Project

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the US Patent Application No. 14/910,890*?. ### Response: iTREAT Project.


Instruction: What does BANDIT Project, US Provisional Patent Application no. 62/620,096 do?

Output: None None

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does BANDIT Project, US Provisional Patent Application no. 62/620,096 do?. ### Response: None None.


Instruction: What table represents the relationships of writing group members that may be perceived as actual or reasonably perceived conflicts of interest as reported on the Disclosure Questionnaire?

Output: stroke*iTREAT Project

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What table represents the relationships of writing group members that may be perceived as actual or reasonably perceived conflicts of interest as reported on the Disclosure Questionnaire?. ### Response: stroke*iTREAT Project.


Instruction: All members of the writing group are required to complete and submit what?

Output: Disclosure Questionnaire

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: All members of the writing group are required to complete and submit what?. ### Response: Disclosure Questionnaire.


Instruction: What percentage of the person’s gross income is considered to be significant?

Output: 5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the person’s gross income is considered to be significant?. ### Response: 5%.


Instruction: How much voting stock or share of the entity does the person own?

Output: 5% or more

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much voting stock or share of the entity does the person own?. ### Response: 5% or more.


Instruction: What is considered significant if the person receives $10 000 or more during any 12-month period?

Output: A relationship

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is considered significant if the person receives $10 000 or more during any 12-month period?. ### Response: A relationship.


Instruction: How much of the fair market value of the entity does the person own?

Output: $10 000 or more

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the fair market value of the entity does the person own?. ### Response: $10 000 or more.


Instruction: What is a relationship considered to be if it is less than "significant"?

Output: modest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a relationship considered to be if it is less than "significant"?. ### Response: modest.


Instruction: Member Employment Research GrantOther Research SupportSpeakers’ Bureau/Honoraria Expert WitnessOwnership InterestConsultant/Advisory Board OtherReviewer Disclosures Reviewer EmploymentResearch GrantWho is the speaker's bureau?

Output: Genentech

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Member Employment Research GrantOther Research SupportSpeakers’ Bureau/Honoraria Expert WitnessOwnership InterestConsultant/Advisory Board OtherReviewer Disclosures Reviewer EmploymentResearch GrantWho is the speaker's bureau?. ### Response: Genentech.


Instruction: Who is the NIH (investigator)?

Output: principal investigator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the NIH (investigator)?. ### Response: principal investigator.


Instruction: Genentech is what?

Output: TNK

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Genentech is what?. ### Response: TNK.


Instruction: What is Genentech known as?

Output: PRISMS)†; Genentech (TNK

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Genentech known as?. ### Response: PRISMS)†; Genentech (TNK.


Instruction: What is the name of the company that is known as "TNK"?

Output: Genentech

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the company that is known as "TNK"?. ### Response: Genentech.


Instruction: When was this file downloaded?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this file downloaded?. ### Response: April 28, 2023.


Instruction: What is the abbreviation for the MDRD equation?

Output: 186 x (Creat / 88.4)-1.154 x (mean age)-0.203 x (0.742 x (proportion female%))

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the abbreviation for the MDRD equation?. ### Response: 186 x (Creat / 88.4)-1.154 x (mean age)-0.203 x (0.742 x (proportion female%)).


Instruction: How is the GFR approximated?

Output: using creatinine level (umol/l) and average participant demographics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the GFR approximated?. ### Response: using creatinine level (umol/l) and average participant demographics.


Instruction: What does creatinine level mean?

Output: umol/l

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does creatinine level mean?. ### Response: umol/l.


Instruction: How many years have elapsed between the publication of the main trial results and the reporting of the sub -group analysis?

Output: Ten or more years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many years have elapsed between the publication of the main trial results and the reporting of the sub -group analysis?. ### Response: Ten or more years.


Instruction: What is the name of the 2021 guideline for the Secondary Prevention of Ischemic StrokeDevice-Detected Sub-Clinical Atrial Fibrillation (ARTESiA) trial?

Output: GUIDELINESKleindorfer et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2021 guideline for the Secondary Prevention of Ischemic StrokeDevice-Detected Sub-Clinical Atrial Fibrillation (ARTESiA) trial?. ### Response: GUIDELINESKleindorfer et al.


Instruction: What year did Am Heart J.189:137–145?

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Am Heart J.189:137–145?. ### Response: 2017.


Instruction: What is the name of the Nordic Atrial Fibrillation and Stroke study?

Output: NOR-FIB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Nordic Atrial Fibrillation and Stroke study?. ### Response: NOR-FIB.


Instruction: What type of stroke and ischaemic attack is atrial fibrillation?

Output: cryptogenic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of stroke and ischaemic attack is atrial fibrillation?. ### Response: cryptogenic.


Instruction: What does Eur Stroke J. 2019:4:172–180?

Output: Atrial fibrillation in cryptogenic stroke and transient ischaemic attack: the Nordic Atrial Fibrillation and Stroke (NOR-FIB) study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Eur Stroke J. 2019:4:172–180?. ### Response: Atrial fibrillation in cryptogenic stroke and transient ischaemic attack: the Nordic Atrial Fibrillation and Stroke (NOR-FIB) study.


Instruction: What does Vitamin K antagonists versus antiplatelet therapy after transient isch-aemic attack or minor ischaemic stroke of presumed arterial origin do?

Output: 14651858.CD001342.pub3 790

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Vitamin K antagonists versus antiplatelet therapy after transient isch-aemic attack or minor ischaemic stroke of presumed arterial origin do?. ### Response: 14651858.CD001342.pub3 790.


Instruction: What is the name of the study that compares warfarin and aspirin for the prevention of recurrent ischemic stroke?

Output: Aspirin Recurrent Stroke Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that compares warfarin and aspirin for the prevention of recurrent ischemic stroke?. ### Response: Aspirin Recurrent Stroke Study Group.


Instruction: What year was Rev. 2012:CD001342 published?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was Rev. 2012:CD001342 published?. ### Response: 2012.


Instruction: Aspirin for the prevention of recurrent ischemic stroke.

Output: Vitamin K antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Aspirin for the prevention of recurrent ischemic stroke.. ### Response: Vitamin K antagonists.


Instruction: What is the doi: 10.1056/NEJMoa011258 791?

Output: Aspirin Recurrent Stroke Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the doi: 10.1056/NEJMoa011258 791?. ### Response: Aspirin Recurrent Stroke Study Group.


Instruction: Dipyridamole and acetylsalicylic acid in the secondary prevention of what?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Dipyridamole and acetylsalicylic acid in the secondary prevention of what?. ### Response: stroke.


Instruction: What is ESPRIT?

Output: randomised controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ESPRIT?. ### Response: randomised controlled trial.


Instruction: What is the name of the randomised controlled trial of aspirin and dipyridamole?

Output: ESPRIT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised controlled trial of aspirin and dipyridamole?. ### Response: ESPRIT.


Instruction: How many people were randomized to participate in the trial?

Output: 14651858.CD001342.pub3 790

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were randomized to participate in the trial?. ### Response: 14651858.CD001342.pub3 790.


Instruction: What is the name of the journal that published a study on the effectiveness of antiplatelet therapy in secondary prevention following lacunar stroke?

Output: Lancet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that published a study on the effectiveness of antiplatelet therapy in secondary prevention following lacunar stroke?. ### Response: Lancet.


Instruction: How many strokes did the Lancet report on in 2006?

Output: 367:1665–1673

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes did the Lancet report on in 2006?. ### Response: 367:1665–1673.


Instruction: What is the difference between aspirin and clopidogrel for recurrent stroke?

Output: extended-release dipyridamole

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between aspirin and clopidogrel for recurrent stroke?. ### Response: extended-release dipyridamole.


Instruction: When was the N Engl J Med 359:1238–1251?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the N Engl J Med 359:1238–1251?. ### Response: 2008.


Instruction: What is a dual versus mono antiplatelet therapy?

Output: acute non- cardio embolic ischemic stroke or transient ischemic at-tack

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a dual versus mono antiplatelet therapy?. ### Response: acute non- cardio embolic ischemic stroke or transient ischemic at-tack.


Instruction: What type of therapy is used for acute non- cardio embolic ischemic stroke?

Output: Dual versus mono antiplatelet therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is used for acute non- cardio embolic ischemic stroke?. ### Response: Dual versus mono antiplatelet therapy.


Instruction: What is the name of the meta-analysis that evaluated the efficacy and safety of dual versus mono antiplatelet therapy?

Output: updated meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis that evaluated the efficacy and safety of dual versus mono antiplatelet therapy?. ### Response: updated meta-analysis.


Instruction: When will BMC Neurol issue 20:224?

Output: 2020

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When will BMC Neurol issue 20:224?. ### Response: 2020.


Instruction: What can be used to prevent early recurrence after ischaemic stroke or transient isch-aemic attack?

Output: Multiple versus fewer antiplatelet agents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be used to prevent early recurrence after ischaemic stroke or transient isch-aemic attack?. ### Response: Multiple versus fewer antiplatelet agents.


Instruction: Cochrane Database Syst Rev. 2020;8:CD009716. doi: 10.1002/14651858.CD00716.pub2 797.

Output: antiplatelet agents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cochrane Database Syst Rev. 2020;8:CD009716. doi: 10.1002/14651858.CD00716.pub2 797.. ### Response: antiplatelet agents.


Instruction: What is a common cause of IE?

Output: dental procedures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a common cause of IE?. ### Response: dental procedures.


Instruction: What is used to prevent IE in patients at risk?

Output: prophylacticantibiotics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used to prevent IE in patients at risk?. ### Response: prophylacticantibiotics.


Instruction: How many data exist on the risk of or prevention of the IE associated with GI or GUtract procedures?

Output: Few

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many data exist on the risk of or prevention of the IE associated with GI or GUtract procedures?. ### Response: Few.


Instruction: What did the Committee do in the context of thehistorical rationale for recommending antibiotic prophylaxis before a dental procedure?

Output: acritical analysis of published data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Committee do in the context of thehistorical rationale for recommending antibiotic prophylaxis before a dental procedure?. ### Response: acritical analysis of published data.


Instruction: What factors were considered in the analysis of published data?

Output: frequency, nature, magnitude, and duration ofbacteremia associated with dental procedures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What factors were considered in the analysis of published data?. ### Response: frequency, nature, magnitude, and duration ofbacteremia associated with dental procedures.


Instruction: What is the impact of dental disease, oral hygiene, and type of dental procedure onbacteremia?

Output: antibiotic prophylaxis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact of dental disease, oral hygiene, and type of dental procedure onbacteremia?. ### Response: antibiotic prophylaxis.


Instruction: What does antibiotic prophylaxis have on bacteremia from a dental procedure?

Output: impact

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does antibiotic prophylaxis have on bacteremia from a dental procedure?. ### Response: impact.


Instruction: When was the Circulation October 9, 2017?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circulation October 9, 2017?. ### Response: 2007.


Instruction: What is bacteremia related to?

Output: dental procedures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is bacteremia related to?. ### Response: dental procedures.


Instruction: What is the date of publication of this study?

Output: October 9, 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the date of publication of this study?. ### Response: October 9, 2007.


Instruction: What are patients with cancer a population at high risk for?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients with cancer a population at high risk for?. ### Response: stroke.


Instruction: What is the association between cancer and stroke not surprising?

Output: given the prevalence of these conditions and the commonly shared risk factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association between cancer and stroke not surprising?. ### Response: given the prevalence of these conditions and the commonly shared risk factors.


Instruction: What are some of the potential mecha-nisms?

Output: procoagulant conditions, direct invasion or compression of blood vessels, radiation arteriopathies, infections (eg, aspergillosis), and secondary effects of chemotherapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the potential mecha-nisms?. ### Response: procoagulant conditions, direct invasion or compression of blood vessels, radiation arteriopathies, infections (eg, aspergillosis), and secondary effects of chemotherapy.


Instruction: What are the common shared risk factors for stroke?

Output: systemic embolism 0.52 (95% CI, 0.22–1.21) and nonmajor bleeding events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the common shared risk factors for stroke?. ### Response: systemic embolism 0.52 (95% CI, 0.22–1.21) and nonmajor bleeding events.


Instruction: What has been a main focus of the stroke prevention efforts in these patients?

Output: procoagulant mechanisms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been a main focus of the stroke prevention efforts in these patients?. ### Response: procoagulant mechanisms.


Instruction: What are often prescribed?

Output: antiplatelets or anticoagulants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are often prescribed?. ### Response: antiplatelets or anticoagulants.


Instruction: What are anticoagulants often prescribed for?

Output: prevention of cardioembolism from AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are anticoagulants often prescribed for?. ### Response: prevention of cardioembolism from AF.


Instruction: What is the best choice for an antithrombotic agent?

Output: hypercoagulable state

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the best choice for an antithrombotic agent?. ### Response: hypercoagulable state.


Instruction: Low-molecular-weight heparin agents are commonly used when a hypercoagulable state is suspected?

Output: empirically

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Low-molecular-weight heparin agents are commonly used when a hypercoagulable state is suspected?. ### Response: empirically.


Instruction: What is the best anticoagulation regimen for the prevention of cardioembolism from AF?

Output: 651

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the best anticoagulation regimen for the prevention of cardioembolism from AF?. ### Response: 651.


Instruction: What is a specific situation in these patients that has been more adequately studied?

Output: the best anticoagulation regimen for the prevention of cardioembolism from AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a specific situation in these patients that has been more adequately studied?. ### Response: the best anticoagulation regimen for the prevention of cardioembolism from AF.


Instruction: What is extrapolated from subgroup analysis of the large ran-domized clinical trials of anticoagulation?

Output: the best anticoagulation regimen for the prevention of cardioembolism from AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is extrapolated from subgroup analysis of the large ran-domized clinical trials of anticoagulation?. ### Response: the best anticoagulation regimen for the prevention of cardioembolism from AF.


Instruction: What section of the ROCKET AF trial refers to Neoplastic Vasculitis?

Output: Section 5.13.3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What section of the ROCKET AF trial refers to Neoplastic Vasculitis?. ### Response: Section 5.13.3.


Instruction: What were the rates of stroke and systemic embolism in AF and history of cancer?

Output: 0.52

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the rates of stroke and systemic embolism in AF and history of cancer?. ### Response: 0.52.


Instruction: What was the rate of nonmajor bleeding events in patients with AF?

Output: 1.09

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the rate of nonmajor bleeding events in patients with AF?. ### Response: 1.09.


Instruction: How was the efficacy and safety of apixaban comparable to those of warfarin?

Output: comparable

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the efficacy and safety of apixaban comparable to those of warfarin?. ### Response: comparable.


Instruction: What drug was comparable to warfarin in patients with AF and history of cancer in the ARISTOTLE trial?

Output: apixaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug was comparable to warfarin in patients with AF and history of cancer in the ARISTOTLE trial?. ### Response: apixaban.


Instruction: What was supported by claims data analy-sis looking at bleeding events of rivaroxaban?

Output: apixaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was supported by claims data analy-sis looking at bleeding events of rivaroxaban?. ### Response: apixaban.


Instruction: How much of apixaban was downloaded from http://ahajournals.org by on April 28, 2023?

Output: 0.37

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of apixaban was downloaded from http://ahajournals.org by on April 28, 2023?. ### Response: 0.37.


Instruction: What type of grafts are used for coronary artery bypass grafting?

Output: saphenous vein grafts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of grafts are used for coronary artery bypass grafting?. ### Response: saphenous vein grafts.


Instruction: What is the name of the study that investigated the effect of weight loss on the outcome after a coronary heart bypass?

Output: DiMaria-Ghalili RA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the effect of weight loss on the outcome after a coronary heart bypass?. ### Response: DiMaria-Ghalili RA.


Instruction: In what year was the coron artery dis published?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was the coron artery dis published?. ### Response: 2006.


Instruction: How many veins were grafted?

Output: 403

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many veins were grafted?. ### Response: 403.


Instruction: What is the name of the journal that studies the relationship between body mass index and cardiovascular events after cardiac rehabilitation?

Output: Am J Cardiol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies the relationship between body mass index and cardiovascular events after cardiac rehabilitation?. ### Response: Am J Cardiol.


Instruction: What are the names of the authors of this study?

Output: Batsis JA, Romero-Corral A, Collazo-Clavell ML, Sarr MG, Somers VK, Lopez-Jimenez F

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the authors of this study?. ### Response: Batsis JA, Romero-Corral A, Collazo-Clavell ML, Sarr MG, Somers VK, Lopez-Jimenez F.


Instruction: When was the last time a person had a heart attack?

Output: 1997

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last time a person had a heart attack?. ### Response: 1997.


Instruction: What is the effect of weight loss on predicted car -diovascular risk after bariatric surgery?

Output: change in cardiac risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of weight loss on predicted car -diovascular risk after bariatric surgery?. ### Response: change in cardiac risk.


Instruction: What was the title of the 2007 issue of Silver Spring?

Output: Obesity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the title of the 2007 issue of Silver Spring?. ### Response: Obesity.


Instruction: What is the Obesity Committee of the Council on Nutrition, Physical Activity and Metabolism?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Obesity Committee of the Council on Nutrition, Physical Activity and Metabolism?. ### Response: American Heart Association.


Instruction: What is a scientific statement from the American Heart Association?

Output: Bariatric surgery and cardiovascular risk factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a scientific statement from the American Heart Association?. ### Response: Bariatric surgery and cardiovascular risk factors.


Instruction: What is the name of the journal that studies the safety and efficacy of bariatric surgery in patients with coronary artery disease?

Output: Mayo Clin Proc.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies the safety and efficacy of bariatric surgery in patients with coronary artery disease?. ### Response: Mayo Clin Proc..


Instruction: When did Mayo Clin Proc. 2005:80:1157-1162. doi: 10.4065/80.9.1157?

Output: 408

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Mayo Clin Proc. 2005:80:1157-1162. doi: 10.4065/80.9.1157?. ### Response: 408.


Instruction: What year did Circulation. 2011:123:1683-1701?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Circulation. 2011:123:1683-1701?. ### Response: 2011.


Instruction: What is a clinical trial of the effects of dietary patterns on blood pressure called?

Output: DASH Collaborative Research Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a clinical trial of the effects of dietary patterns on blood pressure called?. ### Response: DASH Collaborative Research Group.


Instruction: What is the name of the collaborative research group?

Output: DASH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the collaborative research group?. ### Response: DASH.


Instruction: When was the N Engl J Med 336:1117-1124?

Output: 1997

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the N Engl J Med 336:1117-1124?. ### Response: 1997.


Instruction: What is the name of the 1997 study that examined the effects of bariatric surgery on the metabolic syn-drome?

Output: Engl J Med.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 1997 study that examined the effects of bariatric surgery on the metabolic syn-drome?. ### Response: Engl J Med..


Instruction: What year did Mayo Clin Proc. 2008:83:897-907?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Mayo Clin Proc. 2008:83:897-907?. ### Response: 2008.


Instruction: Who is Chermesh I?

Output: Hajos J, Mashiach T, Bozhko M, Shani L, Nir RR, Bolotin G

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Chermesh I?. ### Response: Hajos J, Mashiach T, Bozhko M, Shani L, Nir RR, Bolotin G.


Instruction: Where is Shani L?

Output: Mayo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Shani L?. ### Response: Mayo.


Instruction: What is malnutrition in cardiac surgery?

Output: food for thought

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is malnutrition in cardiac surgery?. ### Response: food for thought.


Instruction: What does Eur J Prev Cardiol. 2014:21:475–483?

Output: Malnutrition in cardiac surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Eur J Prev Cardiol. 2014:21:475–483?. ### Response: Malnutrition in cardiac surgery.


Instruction: What is the impact of body mass index and albumin on morbidity and mortality after cardiac surgery?

Output: 411. Engelman DT, Adams DH, Byrne JG, Aranki SF, Collins JJ Jr, Couper GS, Allred EN, Cohn LH, Rizzo RJ. Impact of body mass index and albumin on morbidity and mortality after cardiac surgery. J Thorac Cardiovasc Surg. 1999;118:866–873. 412

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact of body mass index and albumin on morbidity and mortality after cardiac surgery?. ### Response: 411. Engelman DT, Adams DH, Byrne JG, Aranki SF, Collins JJ Jr, Couper GS, Allred EN, Cohn LH, Rizzo RJ. Impact of body mass index and albumin on morbidity and mortality after cardiac surgery. J Thorac Cardiovasc Surg. 1999;118:866–873. 412.


Instruction: What was the J Thorac Cardiovasc Surg. 1999;118:866–873. Attendees of cardiac surgery are evaluated by what two factors?

Output: body mass index and albumin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the J Thorac Cardiovasc Surg. 1999;118:866–873. Attendees of cardiac surgery are evaluated by what two factors?. ### Response: body mass index and albumin.


Instruction: What is the name of the study that examined the nutritional status and postoperative outcomes of elderly CABG patients?

Output: DiMaria-Ghalili RA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined the nutritional status and postoperative outcomes of elderly CABG patients?. ### Response: DiMaria-Ghalili RA.


Instruction: What does DiMaria-Ghalili say changes in body mass index and late postoperative outcomes in elderly coronary bypass grafting patients do?

Output: nutritional status

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does DiMaria-Ghalili say changes in body mass index and late postoperative outcomes in elderly coronary bypass grafting patients do?. ### Response: nutritional status.


Instruction: What is a follow-up study of coronary bypass grafting patients?

Output: clinical trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a follow-up study of coronary bypass grafting patients?. ### Response: clinical trial.


Instruction: What is the name of the study?

Output: A clinical trial of the effects of dietary patterns

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study?. ### Response: A clinical trial of the effects of dietary patterns.


Instruction: What percentage of patients failed to reach therapeutic ACT values during CPB?

Output: 17%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients failed to reach therapeutic ACT values during CPB?. ### Response: 17%.


Instruction: What is the optimal initial unfractio-nated heparin bolus dose?

Output: 5,000 units

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the optimal initial unfractio-nated heparin bolus dose?. ### Response: 5,000 units.


Instruction: What percentage of patients have therapeutic ACT values?

Output: >480 seconds

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients have therapeutic ACT values?. ### Response: >480 seconds.


Instruction: What may occur when using the ACTassay alone?

Output: an overestimation ofheparin concentration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may occur when using the ACTassay alone?. ### Response: an overestimation ofheparin concentration.


Instruction: Hypothermia, reduced he-moglobin concentration, and hypo fibrinogenemia are examples of what?

Output: Falsely elevated ACT values

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hypothermia, reduced he-moglobin concentration, and hypo fibrinogenemia are examples of what?. ### Response: Falsely elevated ACT values.


Instruction: What is not associated with a concomitant increase in heparin concentration?

Output: phar-macologic agents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not associated with a concomitant increase in heparin concentration?. ### Response: phar-macologic agents.


Instruction: How many patients were in a nonrandomized study?

Output: 42

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were in a nonrandomized study?. ### Response: 42.


Instruction: What did Machinand colleagues demonstrate during hypothermic CPB?

Output: prolongation of ACTvalues

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Machinand colleagues demonstrate during hypothermic CPB?. ### Response: prolongation of ACTvalues.


Instruction: What is hy-pothermia and hemodilution using a number of ACTtechnologies while plasma antifactor Xa heparin levelactivity remained constant?

Output: ACT prolongation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hy-pothermia and hemodilution using a number of ACTtechnologies while plasma antifactor Xa heparin levelactivity remained constant?. ### Response: ACT prolongation.


Instruction: Maintaining ACT values during CPB without HEparin concentration monitoring may result in lower doses of what?

Output: heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Maintaining ACT values during CPB without HEparin concentration monitoring may result in lower doses of what?. ### Response: heparin.


Instruction: What happens during CPB?

Output: plasma coagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What happens during CPB?. ### Response: plasma coagulation.


Instruction: Whole blood heparin concentration assays are statisti-cally more closely correlated with plasma anti-Xa levelsthan what?

Output: the ACT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Whole blood heparin concentration assays are statisti-cally more closely correlated with plasma anti-Xa levelsthan what?. ### Response: the ACT.


Instruction: What is performed alongside a functional test of clotting, such as an ACT?

Output: heparin concentration tests

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is performed alongside a functional test of clotting, such as an ACT?. ### Response: heparin concentration tests.


Instruction: What provides important safety data?

Output: therapeutic functional con ﬁrmationof anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What provides important safety data?. ### Response: therapeutic functional con ﬁrmationof anticoagulation.


Instruction: How many patients were in a randomized controlled trial?

Output: 200

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were in a randomized controlled trial?. ### Response: 200.


Instruction: What did adhesion to heparin con-centration maintenance protocol lead to?

Output: a signi ﬁcantreduction in thrombin generation, ﬁbrinolysis, andneutrophil activation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did adhesion to heparin con-centration maintenance protocol lead to?. ### Response: a signi ﬁcantreduction in thrombin generation, ﬁbrinolysis, andneutrophil activation.


Instruction: How many seconds did Despotis and associates randomize patients to ACT-based man-agement?

Output: 480

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many seconds did Despotis and associates randomize patients to ACT-based man-agement?. ### Response: 480.


Instruction: How many unitsunfractionated heparin doses were used to maintain ACT values>480 seconds?

Output: 5,000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many unitsunfractionated heparin doses were used to maintain ACT values>480 seconds?. ### Response: 5,000.


Instruction: What did patients in the concentration group report a higher dose of?

Output: heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did patients in the concentration group report a higher dose of?. ### Response: heparin.