Instruction: What percentage of patients were considered unsuitable for VKA therapy because of a physician's judgment?

Output: one-half

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients were considered unsuitable for VKA therapy because of a physician's judgment?. ### Response: one-half.


Instruction: Why was VKA inappropriate?

Output: a physician’s judg-ment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was VKA inappropriate?. ### Response: a physician’s judg-ment.


Instruction: Why was one-fourth of patients choosing not to take a VKA?

Output: because of a speciﬁ  c risk of bleeding, and one-fourth because of the patient’s preference not to take a VKA as the sole reason

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was one-fourth of patients choosing not to take a VKA?. ### Response: because of a speciﬁ  c risk of bleeding, and one-fourth because of the patient’s preference not to take a VKA as the sole reason.


Instruction: What is combination therapy more effective in reducing in patients with AF?

Output: the risk of nonfatal stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is combination therapy more effective in reducing in patients with AF?. ### Response: the risk of nonfatal stroke.


Instruction: What increases the risk of nonfatal stroke in patients with AF?

Output: combination therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What increases the risk of nonfatal stroke in patients with AF?. ### Response: combination therapy.


Instruction: What does aspirin alone increase?

Output: the risk of non-fatal major extracranial bleeds

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does aspirin alone increase?. ### Response: the risk of non-fatal major extracranial bleeds.


Instruction: Why is anti-thrombotic therapy for AF evolving rapidly?

Output: the development of new oral anticoagulants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is anti-thrombotic therapy for AF evolving rapidly?. ### Response: the development of new oral anticoagulants.


Instruction: What is the name of the new oral anticoagulants that target different parts of the coagulation path-way?

Output: 2.1.6 New Oral Anticoagulants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the new oral anticoagulants that target different parts of the coagulation path-way?. ### Response: 2.1.6 New Oral Anticoagulants.


Instruction: What are direct thrombin inhibitors?

Output: dabigatran) and direct factor Xa inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are direct thrombin inhibitors?. ### Response: dabigatran) and direct factor Xa inhibitors.


Instruction: What is a direct thrombin inhibitor?

Output: dabigatran

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a direct thrombin inhibitor?. ### Response: dabigatran.


Instruction: What are apixa-ban, rivaroxaban, and edoxaban?

Output: direct factor Xa inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are apixa-ban, rivaroxaban, and edoxaban?. ### Response: direct factor Xa inhibitors.


Instruction: When will results of large phase 3 clinical trials of these agents be published?

Output: soon

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When will results of large phase 3 clinical trials of these agents be published?. ### Response: soon.


Instruction: Why is ximelagatran no longer approved for use by regulatory agencies?

Output: concerns about severe liver toxicity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is ximelagatran no longer approved for use by regulatory agencies?. ### Response: concerns about severe liver toxicity.


Instruction: What was a proof of principle that a direct thrombin inhibitor can achieve?

Output: similar protection against stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a proof of principle that a direct thrombin inhibitor can achieve?. ### Response: similar protection against stroke.


Instruction: What type of inhibitor can achieve similar protection against stroke compared to warfarin?

Output: direct thrombin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of inhibitor can achieve similar protection against stroke compared to warfarin?. ### Response: direct thrombin.


Instruction: What is the proof of principle?

Output: combination therapy is more effective in reducing the risk of nonfatal stroke in patients with AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the proof of principle?. ### Response: combination therapy is more effective in reducing the risk of nonfatal stroke in patients with AF.


Instruction: What is the name of the Randomized Evaluation of Long-Term Anti-coagulation Therapy trial?

Output: RE-LY

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Randomized Evaluation of Long-Term Anti-coagulation Therapy trial?. ### Response: RE-LY.


Instruction: Who reported the RE-LY trial on February 10, 2012?

Output: Kimberly Henricks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who reported the RE-LY trial on February 10, 2012?. ### Response: Kimberly Henricks.


Instruction: What was Kimberly Henricks' name?

Output: American College of Chest Physicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was Kimberly Henricks' name?. ### Response: American College of Chest Physicians.


Instruction: What is not recommended for IV fibrinolytic agents other than alteplase?

Output: The administration of IV defibrinogenating agents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended for IV fibrinolytic agents other than alteplase?. ### Response: The administration of IV defibrinogenating agents.


Instruction: What has not shown benefit from the administration of IV streptokinase within 6 weeks?

Output: RCT data to support additional clinical benefit of sonothrombolysis as adjuvant therapy for IV fibrinolysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has not shown benefit from the administration of IV streptokinase within 6 weeks?. ### Response: RCT data to support additional clinical benefit of sonothrombolysis as adjuvant therapy for IV fibrinolysis.


Instruction: How long after stroke is IV streptokinase administered?

Output: 6 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after stroke is IV streptokinase administered?. ### Response: 6 hours.


Instruction: How many hours after stroke does desmoteplase take?

Output: 3 to 9 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many hours after stroke does desmoteplase take?. ### Response: 3 to 9 hours.


Instruction: What type of therapy is sonothrombolysis used for?

Output: adjuvant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is sonothrombolysis used for?. ### Response: adjuvant.


Instruction: The use of sonothrombolysis as adjuvant therapy with IV fibrinolysis is not recommended what?

Output: RCT data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The use of sonothrombolysis as adjuvant therapy with IV fibrinolysis is not recommended what?. ### Response: RCT data.


Instruction: Since the publication of the 2013 AIS Guidelines, how many RCTs have shown no clinical benefit?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Since the publication of the 2013 AIS Guidelines, how many RCTs have shown no clinical benefit?. ### Response: 2.


Instruction: What is NOR-SASS?

Output: Norwegian Sonothrombolysis in Acute Stroke Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NOR-SASS?. ### Response: Norwegian Sonothrombolysis in Acute Stroke Study.


Instruction: What study randomized 183 patients to contrast-enhanced sonothrombolysis or sham?

Output: NOR-SASS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What study randomized 183 patients to contrast-enhanced sonothrombolysis or sham?. ### Response: NOR-SASS.


Instruction: How long after onset did neurological improvement and functional outcome differ?

Output: 24 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after onset did neurological improvement and functional outcome differ?. ### Response: 24 hours.


Instruction: What was not statistically significant at 24 hours and 90 days?

Output: Neurological improvement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not statistically significant at 24 hours and 90 days?. ### Response: Neurological improvement.


Instruction: What was not statistically significant in the 2 groups at 90 days?

Output: Neurological improvement at 24 hours and functional outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not statistically significant in the 2 groups at 90 days?. ### Response: Neurological improvement at 24 hours and functional outcome.


Instruction: What was CLOTBUST-ER?

Output: Combined Lysis of Thrombus With Ultrasound and Systemic Tissue Plasminogen Activator [tPA] for Emergent Revascularization in Acute Ischemic Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was CLOTBUST-ER?. ### Response: Combined Lysis of Thrombus With Ultrasound and Systemic Tissue Plasminogen Activator [tPA] for Emergent Revascularization in Acute Ischemic Stroke.


Instruction: How many patients with AIS received IV IV?

Output: 676

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with AIS received IV IV?. ### Response: 676.


Instruction: How many patients with AIS received IV alteplase within 3 or 4.5 hours of symptom onset?

Output: 676

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with AIS received IV alteplase within 3 or 4.5 hours of symptom onset?. ### Response: 676.


Instruction: What was the number of patients randomly allocated to operator independent sonothrombolysis or sham ultrasound?

Output: 335

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the number of patients randomly allocated to operator independent sonothrombolysis or sham ultrasound?. ### Response: 335.


Instruction: Which arm showed neurological improvement, death, and serious adverse events compared to the control arm?

Output: intervention arm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which arm showed neurological improvement, death, and serious adverse events compared to the control arm?. ### Response: intervention arm.


Instruction: What was not statistically different in the intervention arm?

Output: neurological improvement, death, and serious adverse events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not statistically different in the intervention arm?. ### Response: neurological improvement, death, and serious adverse events.


Instruction: There is no RCT data to support additional clinical benefit of sonothrombolysis as adjuvant therapy for IV fibrinolysis?

Output: not recommended

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is no RCT data to support additional clinical benefit of sonothrombolysis as adjuvant therapy for IV fibrinolysis?. ### Response: not recommended.


Instruction: Mechanical thrombectomy3.7.1. Concomitant With IV Alteplase COR LOE New, Revised, or Unchanged?

Output: Patients eligible for IV alteplase should receive IV alteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Mechanical thrombectomy3.7.1. Concomitant With IV Alteplase COR LOE New, Revised, or Unchanged?. ### Response: Patients eligible for IV alteplase should receive IV alteplase.


Instruction: Patients eligible for IV alteplases should receive what even if Mechanical Thrombectomy is being considered?

Output: IV alteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients eligible for IV alteplases should receive what even if Mechanical Thrombectomy is being considered?. ### Response: IV alteplase.


Instruction: When was Data Supplement 1 downloaded from http://ahajournals.org?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Data Supplement 1 downloaded from http://ahajournals.org?. ### Response: April 28, 2023.


Instruction: What is the INR of oral anticoagulation?

Output: 3.0

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the INR of oral anticoagulation?. ### Response: 3.0.


Instruction: What was the difference in embolic events with the moderate-intensity group?

Output: reduction in bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the difference in embolic events with the moderate-intensity group?. ### Response: reduction in bleeding.


Instruction: In a ran-domized trial, what was the average INR?

Output: 3.0 to 4.5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In a ran-domized trial, what was the average INR?. ### Response: 3.0 to 4.5.


Instruction: What is a reduction in bleeding with the moderate-intensity group?

Output: there was no difference in embolic events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a reduction in bleeding with the moderate-intensity group?. ### Response: there was no difference in embolic events.


Instruction: What was noninferior in a study comparing an INR target of 1.5 to 2.5 with a target of 2.0 to 3.0?

Output: lower INR target range

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was noninferior in a study comparing an INR target of 1.5 to 2.5 with a target of 2.0 to 3.0?. ### Response: lower INR target range.


Instruction: What was noninferior in the lower INR target range?

Output: current-generation mechanical aortic prosthetic valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was noninferior in the lower INR target range?. ### Response: current-generation mechanical aortic prosthetic valves.


Instruction: The quality of the evi-dence was what?

Output: low

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The quality of the evi-dence was what?. ### Response: low.


Instruction: What provides a reasonable balance between the risks of thromboembolism and bleeding?

Output: an INR of 2.5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What provides a reasonable balance between the risks of thromboembolism and bleeding?. ### Response: an INR of 2.5.


Instruction: What should the INR be maintained at in patients with an aortic mechanical prosthesis who are at higher risk of thromboembolic complications?

Output: 3.0

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should the INR be maintained at in patients with an aortic mechanical prosthesis who are at higher risk of thromboembolic complications?. ### Response: 3.0.


Instruction: What is a risk factor for AF, hypercoagulable state and older-generation prosthesis?

Output: previous thromboembolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for AF, hypercoagulable state and older-generation prosthesis?. ### Response: previous thromboembolism.


Instruction: Severe LV dysfunction may also increase what?

Output: throm-boembolic risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Severe LV dysfunction may also increase what?. ### Response: throm-boembolic risk.


Instruction: What may increase throm-boembolic risk?

Output: Severe LV dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may increase throm-boembolic risk?. ### Response: Severe LV dysfunction.


Instruction: What is higher with mitral than with aortic mechanical valves?

Output: The incidence of thromboembolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is higher with mitral than with aortic mechanical valves?. ### Response: The incidence of thromboembolism.


Instruction: In what study was the incidence of thromboembolism higher?

Output: mitral

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what study was the incidence of thromboembolism higher?. ### Response: mitral.


Instruction: What is the German Experience with Low Intensity Anticoagulation?

Output: GELIA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the German Experience with Low Intensity Anticoagulation?. ### Response: GELIA.


Instruction: In a study of patients with a mechanical mitral prosthesis, a lower INR range was associated with what?

Output: lower survival rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In a study of patients with a mechanical mitral prosthesis, a lower INR range was associated with what?. ### Response: lower survival rate.


Instruction: What was the survival rate associated with the higher INR target range?

Output: 2.5–4.5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the survival rate associated with the higher INR target range?. ### Response: 2.5–4.5.


Instruction: Patient compliance may be challenging with what goals?

Output: higher INR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patient compliance may be challenging with what goals?. ### Response: higher INR.


Instruction: What percentage of the time were patients with a target INR between 2.0 and 3.5 within the range of 2.0 to 3.5?

Output: 74.5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the time were patients with a target INR between 2.0 and 3.5 within the range of 2.0 to 3.5?. ### Response: 74.5%.


Instruction: What percentage were patients within range of 3.0 to 4.5?

Output: 44.5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage were patients within range of 3.0 to 4.5?. ### Response: 44.5%.


Instruction: How much of the time do patients with a mechani-cal mitral valve use anti-platelet therapy?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the time do patients with a mechani-cal mitral valve use anti-platelet therapy?. ### Response: %.


Instruction: What is the INR target of a patient?

Output: 3.0

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the INR target of a patient?. ### Response: 3.0.


Instruction: How did prior recommendations about the use of anti platelet therapy be derived?

Output: from the protocols used in the pivotal randomized stud-ies showing the safety and effectiveness of this technology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did prior recommendations about the use of anti platelet therapy be derived?. ### Response: from the protocols used in the pivotal randomized stud-ies showing the safety and effectiveness of this technology.


Instruction: What did the small and underpowered ARTE trial suggest?

Output: single-agent therapy, compared with dual-agent ther -apy, tended to reduce the risk of major adverse events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the small and underpowered ARTE trial suggest?. ### Response: single-agent therapy, compared with dual-agent ther -apy, tended to reduce the risk of major adverse events.


Instruction: What were the protocols adopted from?

Output: studies of patients undergoing PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the protocols adopted from?. ### Response: studies of patients undergoing PCI.


Instruction: What did Clopidogrel After Transcatheter Aortic Valve Implantation) suggest?

Output: anti-platelet therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Clopidogrel After Transcatheter Aortic Valve Implantation) suggest?. ### Response: anti-platelet therapy.


Instruction: What tended to reduce the risk of major adverse events after TAVI?

Output: single-agent therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What tended to reduce the risk of major adverse events after TAVI?. ### Response: single-agent therapy.


Instruction: When were there no Downloaded from http://ahajournals.org by?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When were there no Downloaded from http://ahajournals.org by?. ### Response: April 28, 2023.


Instruction: What should all hospitals care for stroke patients in a stroke system of care develop, adopt, and adhere to?

Output: care protocols

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should all hospitals care for stroke patients in a stroke system of care develop, adopt, and adhere to?. ### Response: care protocols.


Instruction: What should care protocols reflect?

Output: current care guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should care protocols reflect?. ### Response: current care guidelines.


Instruction: What year was the C-EORecommendation unchanged from?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the C-EORecommendation unchanged from?. ### Response: 2013.


Instruction: What year were COR and LOE added to conform with ACC/AHA 2015 Recommandation Classification System?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year were COR and LOE added to conform with ACC/AHA 2015 Recommandation Classification System?. ### Response: 2013.


Instruction: What should hospitals establish that ensure safe and efficient patient care?

Output: hand-off and transfer protocols and procedures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should hospitals establish that ensure safe and efficient patient care?. ### Response: hand-off and transfer protocols and procedures.


Instruction: What should protocols for interhospital transfer of patients be established?

Output: approved beforehand

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should protocols for interhospital transfer of patients be established?. ### Response: approved beforehand.


Instruction: What should be established and approved beforehand so that efficient patient transfers can be accomplished at all hours of the day and night?

Output: Protocols for interhospital transfer of patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be established and approved beforehand so that efficient patient transfers can be accomplished at all hours of the day and night?. ### Response: Protocols for interhospital transfer of patients.


Instruction: What is unchanged from 2013 Stroke Systems of Care?

Output: C-EORecommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is unchanged from 2013 Stroke Systems of Care?. ### Response: C-EORecommendation.


Instruction: COR and LOE added to conform with what?

Output: ACC/AHA 2015 Recommendation Classification System

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: COR and LOE added to conform with what?. ### Response: ACC/AHA 2015 Recommendation Classification System.


Instruction: What does Mechanical thrombectomy require the patient to be at?

Output: an experienced stroke center

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Mechanical thrombectomy require the patient to be at?. ### Response: an experienced stroke center.


Instruction: What should be designed, executed, and monitored to emphasize?

Output: expeditious assessment and treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be designed, executed, and monitored to emphasize?. ### Response: expeditious assessment and treatment.


Instruction: What should be monitored to emphasize expeditious assessment and treatment?

Output: Systems

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be monitored to emphasize expeditious assessment and treatment?. ### Response: Systems.


Instruction: Facilities are encouraged to consider preestablished criteria that can be used to credential individuals who can perform safe and timely intra-arterial revascularization procedures?

Output: Outcomes for all patients should be tracked. Facilities are encouraged to consider preestablished criteria that can be used to credential individuals who can perform safe and timely intra-arterial revascularization procedures such as those agreed on by the Committee for Advanced Subspecialty Training of the Society of Neurological Surgeons

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Facilities are encouraged to consider preestablished criteria that can be used to credential individuals who can perform safe and timely intra-arterial revascularization procedures?. ### Response: Outcomes for all patients should be tracked. Facilities are encouraged to consider preestablished criteria that can be used to credential individuals who can perform safe and timely intra-arterial revascularization procedures such as those agreed on by the Committee for Advanced Subspecialty Training of the Society of Neurological Surgeons.


Instruction: What was the Committee for Advanced Subspecialty Training of the Society of Neurological Surgeons in conjunction with other professional societies?

Output: intra-arterial revascularization procedures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the Committee for Advanced Subspecialty Training of the Society of Neurological Surgeons in conjunction with other professional societies?. ### Response: intra-arterial revascularization procedures.


Instruction: What was reworded for clarity from 2015 Endovascular?

Output: IIb C-LDRecommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was reworded for clarity from 2015 Endovascular?. ### Response: IIb C-LDRecommendation.


Instruction: What is the Classification System?

Output: AHA 2015 Recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Classification System?. ### Response: AHA 2015 Recommendation.


Instruction: Where is Table XCV found?

Output: online Data Supplement 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Table XCV found?. ### Response: online Data Supplement 1.


Instruction: What is useful for primary stroke centers and other healthcare facilities?

Output: AHA 2015 Recommendation Classification System

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is useful for primary stroke centers and other healthcare facilities?. ### Response: AHA 2015 Recommendation Classification System.


Instruction: What is performed to most appropriately select patients for transfer for mechanical thrombectomy?

Output: emergency noninvasive intracranial vascular imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is performed to most appropriately select patients for transfer for mechanical thrombectomy?. ### Response: emergency noninvasive intracranial vascular imaging.


Instruction: LOE amended to conform with what?

Output: ACC/AHA 2015 Recommendation Classification System

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: LOE amended to conform with what?. ### Response: ACC/AHA 2015 Recommendation Classification System.


Instruction: What is the Recommendation Classification System?

Output: AHA 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Recommendation Classification System?. ### Response: AHA 2015.


Instruction: Where is Table XCV located?

Output: online Data Supplement 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Table XCV located?. ### Response: online Data Supplement 1.


Instruction: What is hypothermia after acute ischemic stroke?

Output: Multimodal neuroprotective therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hypothermia after acute ischemic stroke?. ### Response: Multimodal neuroprotective therapy.


Instruction: What is multimodal neuroprotective therapy?

Output: induced hypothermia after ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is multimodal neuroprotective therapy?. ### Response: induced hypothermia after ischemic stroke.


Instruction: How many(suppl):S126-S128 are there?

Output: 40

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many(suppl):S126-S128 are there?. ### Response: 40.


Instruction: Who published Management of Aneurysmal Subarachnoid Hemorrhage 1733?

Output: Connolly et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published Management of Aneurysmal Subarachnoid Hemorrhage 1733?. ### Response: Connolly et al.


Instruction: What is the name of the 2013 ACCF/AHA guideline for the manage-ment of heart failure?

Output: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2013 ACCF/AHA guideline for the manage-ment of heart failure?. ### Response: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.


Instruction: What are the names of the Task Force on Practice Guidelines?

Output: American College of Cardiology Foundation/American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the Task Force on Practice Guidelines?. ### Response: American College of Cardiology Foundation/American Heart Association.


Instruction: What is Hydralazine for essential hypertension?

Output: 272

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Hydralazine for essential hypertension?. ### Response: 272.


Instruction: What is the Cochrane Database Syst Rev. 2011:CD004934?

Output: Hydralazine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Cochrane Database Syst Rev. 2011:CD004934?. ### Response: Hydralazine.


Instruction: What is an Endocrine Society Clinical Practice Guideline?

Output: Case detection, diagnosis, and treatment of patients with primary aldosteronism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an Endocrine Society Clinical Practice Guideline?. ### Response: Case detection, diagnosis, and treatment of patients with primary aldosteronism.


Instruction: What is a multicentre safety and efficacy study of catater-based renal sympathetic denervation?

Output: SYMPLICITY HTN-3 Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a multicentre safety and efficacy study of catater-based renal sympathetic denervation?. ### Response: SYMPLICITY HTN-3 Investigators.


Instruction: What is the SYMPLICITY HTN-2 trial?

Output: a randomised controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the SYMPLICITY HTN-2 trial?. ### Response: a randomised controlled trial.


Instruction: What is a multicentre safety and proof-of-principle study?

Output: Catheter-based renal sympathetic denervation for resistant hyperten-sion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a multicentre safety and proof-of-principle study?. ### Response: Catheter-based renal sympathetic denervation for resistant hyperten-sion.


Instruction: What is a randomised controlled trial?

Output: SYMPLICITY HTN-2 Investigators, Esler MD, Krum H, Sobotka PA, Schlaich MP, Schmieder RE, Bohm M. Renal sympathetic de-nervation in patients with treatment-resistant hypertension (the SYMPLICITY HTN-2 trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a randomised controlled trial?. ### Response: SYMPLICITY HTN-2 Investigators, Esler MD, Krum H, Sobotka PA, Schlaich MP, Schmieder RE, Bohm M. Renal sympathetic de-nervation in patients with treatment-resistant hypertension (the SYMPLICITY HTN-2 trial.


Instruction: What reduces left ventricular hy-pertrophy and improves cardiac function in patients with resistant hypertension?

Output: Renal sympathetic denervation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What reduces left ventricular hy-pertrophy and improves cardiac function in patients with resistant hypertension?. ### Response: Renal sympathetic denervation.


Instruction: What is the name of the study that investigated renal denervation for resistant hypertension?

Output: SYMPLICITY HTN-3 Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated renal denervation for resistant hypertension?. ### Response: SYMPLICITY HTN-3 Investigators.


Instruction: What is diltiazem and left ventricular function after myocardial infarction?

Output: The interaction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is diltiazem and left ventricular function after myocardial infarction?. ### Response: The interaction.


Instruction: What is the name of the study that evaluated the effect of amlodipine on mode of death among patients with advanced heart failure?

Output: PRAISE Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated the effect of amlodipine on mode of death among patients with advanced heart failure?. ### Response: PRAISE Trial.


Instruction: When was the PRAISE Trial conducted?

Output: 1998

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the PRAISE Trial conducted?. ### Response: 1998.


Instruction: What is the name of the prospective randomized amlodipine survival evaluation trial?

Output: PRAISE Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective randomized amlodipine survival evaluation trial?. ### Response: PRAISE Trial.


Instruction: When was the Am J Cardiol 82:881-887?

Output: 1998

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Am J Cardiol 82:881-887?. ### Response: 1998.


Instruction: What is felodipin a supplementary vasodilator for?

Output: patients with chronic heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is felodipin a supplementary vasodilator for?. ### Response: patients with chronic heart failure.


Instruction: What is V-HEFT III: Vasodilator-Heart Failure Trial?

Output: Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is V-HEFT III: Vasodilator-Heart Failure Trial?. ### Response: Study Group.


Instruction: What is the name of the study group that studies supplementary vasodiator therapy in patients with chronic heart failure?

Output: V-HEFT III: Vasodilator-Heart Failure Trial (V-HEFT) Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study group that studies supplementary vasodiator therapy in patients with chronic heart failure?. ### Response: V-HEFT III: Vasodilator-Heart Failure Trial (V-HEFT) Study Group.


Instruction: What is the effect of sustained-release moxonidine on central sympathetic inhibition?

Output: Adverse mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of sustained-release moxonidine on central sympathetic inhibition?. ### Response: Adverse mortality.


Instruction: How much did fish oil reduce mortality at 42months?

Output: 20%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much did fish oil reduce mortality at 42months?. ### Response: 20%.


Instruction: What is effective in reducing triglyceride levels?

Output: Pharmacological treatment with fish oil

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is effective in reducing triglyceride levels?. ### Response: Pharmacological treatment with fish oil.


Instruction: How should all patients be counseled about the need for lifestyle modification?

Output: therapy with medications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How should all patients be counseled about the need for lifestyle modification?. ### Response: therapy with medications.


Instruction: What should be incorporated in patients with SIHD with BP 140/90 mm Hg or higher?

Output: antihypertensive drug therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be incorporated in patients with SIHD with BP 140/90 mm Hg or higher?. ### Response: antihypertensive drug therapy.


Instruction: What type of drug therapy should be instituted in addition to or after a trial of lifestyle modification?

Output: antihypertensive

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of drug therapy should be instituted in addition to or after a trial of lifestyle modification?. ### Response: antihypertensive.


Instruction: What type of drugs are used to treat highBP?

Output: ACE inhibitors and/or betablockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of drugs are used to treat highBP?. ### Response: ACE inhibitors and/or betablockers.


Instruction: What is the level of evidence for the use of ACE inhibitors and betablockers?

Output: B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the level of evidence for the use of ACE inhibitors and betablockers?. ### Response: B.


Instruction: What is an important independent risk factor forischemic cardiovascular events?

Output: Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an important independent risk factor forischemic cardiovascular events?. ### Response: Hypertension.


Instruction: What has demonstrated a continuous and graded relationship between BP and cardiovascular risk?

Output: Observational studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has demonstrated a continuous and graded relationship between BP and cardiovascular risk?. ### Response: Observational studies.


Instruction: What is the graded relationship between BP and cardiovascular risk?

Output: continuous

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the graded relationship between BP and cardiovascular risk?. ### Response: continuous.


Instruction: In a collaborativemeta-analysis of prospective studies of nearly 1 millionadults without preexisting vascular disease, the risk of avascular death increased linearly over the BP range?

Output: without a thresholdeffect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In a collaborativemeta-analysis of prospective studies of nearly 1 millionadults without preexisting vascular disease, the risk of avascular death increased linearly over the BP range?. ### Response: without a thresholdeffect.


Instruction: What did each increment of 20 mm Hg in systolic BP or 10 mmHg in diastol BP cause?

Output: a doublingof risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did each increment of 20 mm Hg in systolic BP or 10 mmHg in diastol BP cause?. ### Response: a doublingof risk.


Instruction: What should be the first step in treating high BP?

Output: lifestyle measures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be the first step in treating high BP?. ### Response: lifestyle measures.


Instruction: What should BP begin with?

Output: lifestyle measures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should BP begin with?. ### Response: lifestyle measures.


Instruction: What is a key element of the nonpharmacological strategies recommended to improve BP control?

Output: Maintenance of an appropriate body weight

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a key element of the nonpharmacological strategies recommended to improve BP control?. ### Response: Maintenance of an appropriate body weight.


Instruction: How much weight loss results in a decrease in BP?

Output: 5 to 20 mmHg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much weight loss results in a decrease in BP?. ### Response: 5 to 20 mmHg.


Instruction: What is a signifi-cant lowering of BP?

Output: weight loss of 10 kg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a signifi-cant lowering of BP?. ### Response: weight loss of 10 kg.


Instruction: What will be required to lower BP in many patients with SIHD?

Output: therapy with medications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will be required to lower BP in many patients with SIHD?. ### Response: therapy with medications.


Instruction: What is required to lower BP to the desired level?

Output: therapy with medications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is required to lower BP to the desired level?. ### Response: therapy with medications.


Instruction: What has definitively demonstrated a beneficial effect of antihy-pertensive drug therapy on cardiovascular disease risk?

Output: Treatment trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has definitively demonstrated a beneficial effect of antihy-pertensive drug therapy on cardiovascular disease risk?. ### Response: Treatment trials.


Instruction: How many placebo-controlled trials showed that reducing diastolic BP 5 to 6 mm Hg was beneficial?

Output: 17

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many placebo-controlled trials showed that reducing diastolic BP 5 to 6 mm Hg was beneficial?. ### Response: 17.


Instruction: What was associated with a significant reduction in vascular mortality?

Output: reducingdiastolic BP 5 to 6 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with a significant reduction in vascular mortality?. ### Response: reducingdiastolic BP 5 to 6 mm Hg.


Instruction: How much reduction in stroke did a 6 mm Hg population have?

Output: 40%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much reduction in stroke did a 6 mm Hg population have?. ### Response: 40%.


Instruction: What was a 20% reduction in in stroke?

Output: vascular mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a 20% reduction in in stroke?. ### Response: vascular mortality.


Instruction: What was downgraded for indirectness due to the long follow up period?

Output: Outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was downgraded for indirectness due to the long follow up period?. ### Response: Outcomes.


Instruction: How long was hospitalisation at 24 months?

Output: months   Hospitalisation at 24 months   NRS for breathlessness at 3 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was hospitalisation at 24 months?. ### Response: months   Hospitalisation at 24 months   NRS for breathlessness at 3 months.


Instruction: At 3 months, what was NRS for breathlessness?

Output:  NRS for breathlessness at 3 months   6 minute walk test

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: At 3 months, what was NRS for breathlessness?. ### Response:  NRS for breathlessness at 3 months   6 minute walk test.


Instruction: What is the Scandinavian Simvastatin Survival Study (4S)?

Output: heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Scandinavian Simvastatin Survival Study (4S)?. ### Response: heart disease.


Instruction: How many high-risk individuals were enrolled in the MRC/BHF Heart Protection Study?

Output: 20 536

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many high-risk individuals were enrolled in the MRC/BHF Heart Protection Study?. ### Response: 20 536.


Instruction: What was the name of the randomised placebo-controlled trial?

Output: MRC/BHF Heart Protection Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the randomised placebo-controlled trial?. ### Response: MRC/BHF Heart Protection Study.


Instruction: What does statins do after acute coronary syndromes?

Output: Intensive versus moderatelipid lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does statins do after acute coronary syndromes?. ### Response: Intensive versus moderatelipid lowering.


Instruction: What is the effect of pravastatin oncoronary events after myocardial infarction in patients with averagecholesterol levels?

Output: MA, Moye LA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of pravastatin oncoronary events after myocardial infarction in patients with averagecholesterol levels?. ### Response: MA, Moye LA.


Instruction: Who is the investigator of the Cholesterol and Recurrent Events Trial?

Output: Moye LA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the investigator of the Cholesterol and Recurrent Events Trial?. ### Response: Moye LA.


Instruction: How many lipid-independent effects of statins are there in the management of acutecoronary syndromes?

Output: multiple

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many lipid-independent effects of statins are there in the management of acutecoronary syndromes?. ### Response: multiple.


Instruction: What is the name of the randomized controlled trial that evaluated the effects of atorvastatin on early recurrent ischemic events?

Output: MIRACL study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized controlled trial that evaluated the effects of atorvastatin on early recurrent ischemic events?. ### Response: MIRACL study.


Instruction: What are the (pleiotropic) effects of statins in the management of?

Output: acutecoronary syndromes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the (pleiotropic) effects of statins in the management of?. ### Response: acutecoronary syndromes.


Instruction: What is the optimal activatedclotting time during percutaneous coronary intervention: aggregateresults from 6 randomized, controlled trials?

Output: Defining

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the optimal activatedclotting time during percutaneous coronary intervention: aggregateresults from 6 randomized, controlled trials?. ### Response: Defining.


Instruction: What are antiplateletand antithrombin agents used for in the treatment of non-ST-segment elevationacute coronary syndromes?

Output: Excess dosing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are antiplateletand antithrombin agents used for in the treatment of non-ST-segment elevationacute coronary syndromes?. ### Response: Excess dosing.


Instruction: What is the difference between thrombolytic therapy and primary percutaneous coronary intervention for myocardial infarction?

Output: presenting to hospitals without on-site cardiac surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between thrombolytic therapy and primary percutaneous coronary intervention for myocardial infarction?. ### Response: presenting to hospitals without on-site cardiac surgery.


Instruction: What is the current status of percutaneous coronary intervention without on-site surgical backup?

Output: future direction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the current status of percutaneous coronary intervention without on-site surgical backup?. ### Response: future direction.


Instruction: What is a ran-domized controlled trial?

Output: Thrombolytic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a ran-domized controlled trial?. ### Response: Thrombolytic therapy.


Instruction: What is the name of the Society forCardiovascular Angiography and Interventions?

Output: percutaneous coronary intervention without on-sitesurgical backup

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Society forCardiovascular Angiography and Interventions?. ### Response: percutaneous coronary intervention without on-sitesurgical backup.


Instruction: When was the Catheter CardiovascInterv 69:471-8.353?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Catheter CardiovascInterv 69:471-8.353?. ### Response: 2007.


Instruction: What was the outcome of a randomized study in low-risk patients?

Output: Nonemergent coronary angio-plasty without on-site surgical backup

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome of a randomized study in low-risk patients?. ### Response: Nonemergent coronary angio-plasty without on-site surgical backup.


Instruction: What is the name of the meta-analysis of outcomes of nonemergent percu-taneous coronary intervention with and without on-site surgical backup?

Output: a meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis of outcomes of nonemergent percu-taneous coronary intervention with and without on-site surgical backup?. ### Response: a meta-analysis.


Instruction: What was the title of the 2011 meta-analyse?

Output: Am J Ther. 2011;18:e22–8.355

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the title of the 2011 meta-analyse?. ### Response: Am J Ther. 2011;18:e22–8.355.


Instruction: How did Nallamothu BK, Wang Y, Magid DJ, et al. compare hospitalspecialization with primary percutaneous coronary interventions andclinical outcomes?

Output: Relation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Nallamothu BK, Wang Y, Magid DJ, et al. compare hospitalspecialization with primary percutaneous coronary interventions andclinical outcomes?. ### Response: Relation.


Instruction: What is a ST-segment elevation myocardial infarction?

Output: National Registry of Myocardial Infarction-4 analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a ST-segment elevation myocardial infarction?. ### Response: National Registry of Myocardial Infarction-4 analysis.


Instruction: When was the Circulation.113:222–9.356?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circulation.113:222–9.356?. ### Response: 2006.


Instruction: What approach did Brueck M, Bandorski D, Kramer W, et al. use?

Output: transradial versus transfemoral

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What approach did Brueck M, Bandorski D, Kramer W, et al. use?. ### Response: transradial versus transfemoral.


Instruction: What is included for the purpose of transparency?

Output: Relationships that exist with no financial benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is included for the purpose of transparency?. ### Response: Relationships that exist with no financial benefit.


Instruction: What are relationships in this table modest?

Output: unless otherwise noted

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are relationships in this table modest?. ### Response: unless otherwise noted.


Instruction: According to the ACC/AHA, a person has a relevant relationship if: a) The relationship or interest relates to what?

Output: the same or similar subject matter, intellectual property or asset, topic, or issue addressed in the document

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: According to the ACC/AHA, a person has a relevant relationship if: a) The relationship or interest relates to what?. ### Response: the same or similar subject matter, intellectual property or asset, topic, or issue addressed in the document.


Instruction: What happens if the relationship or interest relates to the same or similar subject matter, intellectual property or asset, topic, or issue addressed in the document?

Output: a person has a relevant relationship

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What happens if the relationship or interest relates to the same or similar subject matter, intellectual property or asset, topic, or issue addressed in the document?. ### Response: a person has a relevant relationship.


Instruction: What does the company/entity with whom the relationship exists make?

Output: a drug, drug class, or device addressed in the document

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the company/entity with whom the relationship exists make?. ### Response: a drug, drug class, or device addressed in the document.


Instruction: Who has a reasonable potential for financial, professional, or other personal gain or loss as a result of the issues/content addressed in the document?

Output: the person or a member of the person’s household

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who has a reasonable potential for financial, professional, or other personal gain or loss as a result of the issues/content addressed in the document?. ### Response: the person or a member of the person’s household.


Instruction: What are writing committee members required to recuse themselves from voting on sections to which their specific relationships with industry and other entities may apply?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are writing committee members required to recuse themselves from voting on sections to which their specific relationships with industry and other entities may apply?. ### Response: †.


Instruction: What does ACC indicate?

Output: American College of Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ACC indicate?. ### Response: American College of Cardiology.


Instruction: What is the acronym for the American Heart Association?

Output: AHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the American Heart Association?. ### Response: AHA.


Instruction: What does DCRI stand for?

Output: Duke Clinical Research Institute

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does DCRI stand for?. ### Response: Duke Clinical Research Institute.


Instruction: HFSA stands for what?

Output: Heart Failure Society of America

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: HFSA stands for what?. ### Response: Heart Failure Society of America.


Instruction: WHAT is INTERMACS?

Output: The Interagency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: WHAT is INTERMACS?. ### Response: The Interagency.


Instruction: What does Entresto do?

Output: pulmonary artery pressure reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Entresto do?. ### Response: pulmonary artery pressure reduction.


Instruction: What does VA do with Veterans Affairs?

Output: VA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does VA do with Veterans Affairs?. ### Response: VA.


Instruction: Where can ahajournals.org be accessed?

Output: http://ahajournals.org by on May 3, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can ahajournals.org be accessed?. ### Response: http://ahajournals.org by on May 3, 2023.


Instruction: How is lorcaserin approved for the treatment of obesity?

Output: FDA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is lorcaserin approved for the treatment of obesity?. ### Response: FDA.


Instruction: What is the name of the article that FDA approves for the obesity treatment?

Output: lorcaserin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the article that FDA approves for the obesity treatment?. ### Response: lorcaserin.


Instruction: When was the article accessed?

Output: July 12, 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the article accessed?. ### Response: July 12, 2012.


Instruction: What is the name of the weight-management drug approved by the FDA?

Output: Qsymia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the weight-management drug approved by the FDA?. ### Response: Qsymia.


Instruction: What type of heart failure is a risk factor for bariatric surgery?

Output: systolic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of heart failure is a risk factor for bariatric surgery?. ### Response: systolic.


Instruction: Where is Qsymia manufactured?

Output: Bethesda, MD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Qsymia manufactured?. ### Response: Bethesda, MD.


Instruction: What drug is approved for weight management?

Output: Qsymia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug is approved for weight management?. ### Response: Qsymia.


Instruction: When was the FDA's announcement made?

Output: July 2, 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the FDA's announcement made?. ### Response: July 2, 2012.


Instruction: How many obese patients were treated with Orlistat in 2005?

Output: 246

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many obese patients were treated with Orlistat in 2005?. ### Response: 246.


Instruction: What is a pilot study of heart failure?

Output: Effect of Orlistat

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a pilot study of heart failure?. ### Response: Effect of Orlistat.


Instruction: What is the name of the pilot study?

Output: Congest Heart Fail

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the pilot study?. ### Response: Congest Heart Fail.


Instruction: How many people were enrolled in the trial?

Output: 246

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were enrolled in the trial?. ### Response: 246.


Instruction: What is the impact of body composition, fat distribution and sustained weight loss on cardiac function in obesity?

Output: Bariatric surgery im-proves cardiac function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact of body composition, fat distribution and sustained weight loss on cardiac function in obesity?. ### Response: Bariatric surgery im-proves cardiac function.


Instruction: Int J Cardiol. 2012;159:128-133. doi: 10.1016/j.ijcard.2011.02.036.

Output: 246

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Int J Cardiol. 2012;159:128-133. doi: 10.1016/j.ijcard.2011.02.036.. ### Response: 246.


Instruction: Who represents the American Heart Association Council on Cardiovascular Nursing, Council on Clinical Cardiology, and Council on Nutrition, Physical Activity, and Metabolism?

Output: SJ, Schocken DD, Whellan DJ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who represents the American Heart Association Council on Cardiovascular Nursing, Council on Clinical Cardiology, and Council on Nutrition, Physical Activity, and Metabolism?. ### Response: SJ, Schocken DD, Whellan DJ.


Instruction: Who represents Interdisciplinary Council on Quality of Care and Outcomes Research?

Output: American Heart Association Council on Cardiovascular Nursing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who represents Interdisciplinary Council on Quality of Care and Outcomes Research?. ### Response: American Heart Association Council on Cardiovascular Nursing.


Instruction: What organization promotes self-care in people with heart failure?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What organization promotes self-care in people with heart failure?. ### Response: American Heart Association.


Instruction: What is the name of the scientific statement from the American Heart Association?

Output: State of the science: promoting self-care in persons with heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the scientific statement from the American Heart Association?. ### Response: State of the science: promoting self-care in persons with heart failure.


Instruction: When was Circulation.120:1141–1163. doi: 10.1161/CIRCULATIONAHA.109.192628?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Circulation.120:1141–1163. doi: 10.1161/CIRCULATIONAHA.109.192628?. ### Response: 2009.


Instruction: What does bariatric surgery do in morbid obese patients with severe cardiomyopathy?

Output: im-proves cardiac function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does bariatric surgery do in morbid obese patients with severe cardiomyopathy?. ### Response: im-proves cardiac function.


Instruction: What is the effect of obesity on quality of life and depression in obese patients?

Output: cardiac function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of obesity on quality of life and depression in obese patients?. ### Response: cardiac function.


Instruction: What is the impact of obesity on quality of life and depression in patients with heart failure?

Output: 251

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact of obesity on quality of life and depression in patients with heart failure?. ### Response: 251.


Instruction: When did Eur J Heart Fail. 2006:8:750–755. doi: 10.1016/j.ejheart.2006.02.004?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Eur J Heart Fail. 2006:8:750–755. doi: 10.1016/j.ejheart.2006.02.004?. ### Response: 2006.


Instruction: What does obesity have an impact on?

Output: cardiac function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does obesity have an impact on?. ### Response: cardiac function.


Instruction: In what year was J Gen Intern Med published?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was J Gen Intern Med published?. ### Response: 2012.


Instruction: What is the name of the journal that published a study on exercise training in heart failure?

Output: Heart Fail Rev.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that published a study on exercise training in heart failure?. ### Response: Heart Fail Rev..


Instruction: How many people were diagnosed with heart failure in 2000?

Output: 253

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were diagnosed with heart failure in 2000?. ### Response: 253.


Instruction: What did Barbour KA and Miller NH do in relation to exercise?

Output: Adherence to exercise training in heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Barbour KA and Miller NH do in relation to exercise?. ### Response: Adherence to exercise training in heart failure.


Instruction: How many patients were randomized to culprit artery-only or multivessel PCI during the index hospitaliza-tion?

Output: 296

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were randomized to culprit artery-only or multivessel PCI during the index hospitaliza-tion?. ### Response: 296.


Instruction: What percentage of patients underwent multi-vessel primary PCI?

Output: 72%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients underwent multi-vessel primary PCI?. ### Response: 72%.


Instruction: What percentage of patients underwent multivessel primary PCI?

Output: 72%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients underwent multivessel primary PCI?. ### Response: 72%.


Instruction: What was the primary outcome of death, reinfarction, heart failure, and ischemia-driven revascularization at 12 months?

Output: compos-ite

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary outcome of death, reinfarction, heart failure, and ischemia-driven revascularization at 12 months?. ### Response: compos-ite.


Instruction: How many patients were treated with culprit artery-only PCI in the DANAMI 3?

Output: 31

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with culprit artery-only PCI in the DANAMI 3?. ### Response: 31.


Instruction: What was the 95% confidence interval between 0.24 and 0.84?

Output: 0.49; 95% CI: 0.24 to 0.84; P=0.009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 95% confidence interval between 0.24 and 0.84?. ### Response: 0.49; 95% CI: 0.24 to 0.84; P=0.009.


Instruction: How many patients were in the DANAMI 3 PRIMULTI trial?

Output: 314

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were in the DANAMI 3 PRIMULTI trial?. ### Response: 314.


Instruction: How many patients underwent multivessel staged PCI guided by angiogra-phy and fractional flow reserve before discharge?

Output: 314

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients underwent multivessel staged PCI guided by angiogra-phy and fractional flow reserve before discharge?. ### Response: 314.


Instruction: How many of 313 patients were treated with culprit artery-only PCI?

Output: 68

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many of 313 patients were treated with culprit artery-only PCI?. ### Response: 68.


Instruction: What was the HR of PRAGUE-13?

Output: 0.56

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the HR of PRAGUE-13?. ### Response: 0.56.


Instruction: How many patients were in the PRAGUE-13 trial?

Output: 214

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were in the PRAGUE-13 trial?. ### Response: 214.


Instruction: What was the name of the trial that included 214 patients with Table 1?

Output: PRAGUE-13

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the trial that included 214 patients with Table 1?. ### Response: PRAGUE-13.


Instruction: When was the latest version of ahajournals.org released?

Output: May 3, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the latest version of ahajournals.org released?. ### Response: May 3, 2023.


Instruction: When was this version updated?

Output: August 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this version updated?. ### Response: August 2015.


Instruction: Where did this version come from?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where did this version come from?. ### Response: http://ahajournals.org.


Instruction: What type of studies are needed to confirm these findings?

Output: matory studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of studies are needed to confirm these findings?. ### Response: matory studies.


Instruction: Evidence from2 prospective randomized clinical studies supports increasing what doses of vaccine?

Output: influenza

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Evidence from2 prospective randomized clinical studies supports increasing what doses of vaccine?. ### Response: influenza.


Instruction: Increased serum antibodytiters and better protection from influenzainfection are two ways to increase what?

Output: influenza vaccine doses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Increased serum antibodytiters and better protection from influenzainfection are two ways to increase what?. ### Response: influenza vaccine doses.


Instruction: What did this doing scheme cause?

Output: higher injection site reactions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did this doing scheme cause?. ### Response: higher injection site reactions.


Instruction: What is recommended that patients with SIHD receive an annual influenza vaccination?

Output: standard dose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended that patients with SIHD receive an annual influenza vaccination?. ### Response: standard dose.


Instruction: What is not recommended in postmenopausal women with SIHD with the intent of reducingcardiovascular risk or improving clinical out-comes?

Output: Estrogen therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended in postmenopausal women with SIHD with the intent of reducingcardiovascular risk or improving clinical out-comes?. ### Response: Estrogen therapy.


Instruction: Vitamin C, vitamin E, and beta-carotene supplemen-tation are not recommended with what intent?

Output: reducing cardiovascular risk or improving clinicaloutcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Vitamin C, vitamin E, and beta-carotene supplemen-tation are not recommended with what intent?. ### Response: reducing cardiovascular risk or improving clinicaloutcomes.


Instruction: What is not recommended to treat elevated homocysteine with folate orvitamins B6 and B12 in patients with SIHD?

Output: reducing cardiovascular risk or improvingclinical outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended to treat elevated homocysteine with folate orvitamins B6 and B12 in patients with SIHD?. ### Response: reducing cardiovascular risk or improvingclinical outcomes.


Instruction: What isn't recommended with theintent of reducing cardiovascular risk or improving clinicaloutcomes?

Output: B12

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What isn't recommended with theintent of reducing cardiovascular risk or improving clinicaloutcomes?. ### Response: B12.


Instruction: What is not recommended with the intent of improving symptoms or reducing cardio-vascular risk in patients with SIHD?

Output: Chelation therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended with the intent of improving symptoms or reducing cardio-vascular risk in patients with SIHD?. ### Response: Chelation therapy.


Instruction: What does not recommend treatment with garlic, coenzyme Q10, selenium, or chromium?

Output: reducing cardiovascular risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not recommend treatment with garlic, coenzyme Q10, selenium, or chromium?. ### Response: reducing cardiovascular risk.


Instruction: What can estrogen therapy help prevent?

Output: development of IHD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can estrogen therapy help prevent?. ### Response: development of IHD.


Instruction: What is the effect of estrogen on HDL cholesterol?

Output: increase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of estrogen on HDL cholesterol?. ### Response: increase.


Instruction: What is an increase in HDL cholesterol?

Output: Beneficial effects of exogenousestrogen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an increase in HDL cholesterol?. ### Response: Beneficial effects of exogenousestrogen.


Instruction: What is a decrease in LDL cholesterol called?

Output: 11%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a decrease in LDL cholesterol called?. ### Response: 11%.


Instruction: In addition to increased endothelial function, what is an effect of exogenousestrogen?

Output: increase in HDL cholesterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In addition to increased endothelial function, what is an effect of exogenousestrogen?. ### Response: increase in HDL cholesterol.


Instruction: How many postmenopausal women with CAD were randomized to therapy with medroxy progesterone acetate or placebo?

Output: 2763

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many postmenopausal women with CAD were randomized to therapy with medroxy progesterone acetate or placebo?. ### Response: 2763.


Instruction: What has failed to con-firm a decrease in cardiovascular events with hormonetherapy?

Output: Clinical trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has failed to con-firm a decrease in cardiovascular events with hormonetherapy?. ### Response: Clinical trials.


Instruction: How long did it take to follow up on medroxy progesterone acetate or placebo?

Output: 4.4 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take to follow up on medroxy progesterone acetate or placebo?. ### Response: 4.4 years.


Instruction: How much lower was the LDL cholesterol in the hormone therapy group?

Output: 11%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much lower was the LDL cholesterol in the hormone therapy group?. ### Response: 11%.


Instruction: What was the composite primary endpoint of MI or IHDdeath?

Output: nodifference

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the composite primary endpoint of MI or IHDdeath?. ### Response: nodifference.


Instruction: What was the primary endpoint of MI or IHDdeath?

Output: an early increase in cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary endpoint of MI or IHDdeath?. ### Response: an early increase in cardiovascular events.


Instruction: What was observed in HERS-II?

Output: an early increase in cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was observed in HERS-II?. ### Response: an early increase in cardiovascular events.


Instruction: What is nebivolol used for in elderly heart failure patients with impaired renal function?

Output: safety

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is nebivolol used for in elderly heart failure patients with impaired renal function?. ### Response: safety.


Instruction: What is the name of the randomized trial of valsartan in chronic heart failure?

Output: Valsartan Heart Failure Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized trial of valsartan in chronic heart failure?. ### Response: Valsartan Heart Failure Trial.


Instruction: What is valsartan an angiotensin -receptor blocker?

Output: Valsartan Heart Failure Trial: a large multinational trial to assess the effects of valsartan, an angiotensin -receptor blocker, on morbidity and mortality in chronic congestive heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is valsartan an angiotensin -receptor blocker?. ### Response: Valsartan Heart Failure Trial: a large multinational trial to assess the effects of valsartan, an angiotensin -receptor blocker, on morbidity and mortality in chronic congestive heart failure.


Instruction: What is the name of the large multinational trial to assess the effects of the Valsartans on morbidity and mortality?

Output: Valsartan Heart Failure Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the large multinational trial to assess the effects of the Valsartans on morbidity and mortality?. ### Response: Valsartan Heart Failure Trial.


Instruction: In what year was the New England Journal of Medicine published?

Output: 2001

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was the New England Journal of Medicine published?. ### Response: 2001.


Instruction: What is valsartan an angiotensin-receptor blocker?

Output: Valsartan Heart Failure Trial: a large multinational trial to assess the effects of valsartan, an angiotensin -receptor blocker, on morbidity and mortality in chronic congestive heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is valsartan an angiotensin-receptor blocker?. ### Response: Valsartan Heart Failure Trial: a large multinational trial to assess the effects of valsartan, an angiotensin -receptor blocker, on morbidity and mortality in chronic congestive heart failure.


Instruction: What is the name of the blocker used in chronic congestive heart failure?

Output: valsartan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the blocker used in chronic congestive heart failure?. ### Response: valsartan.


Instruction: What is the name of the 2019 ACC/AHA guideline on the Primary Prevention of Cardiovascular Disease: Executive SummaryCirculation. 2019;140:e563–e595. DOI: 10.1161/CIR.0000000000000677 September 10, 2019 e577What is the best diet for ASCVD prevention?

Output: A diet high in fruits, veg-etables, and whole grains

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2019 ACC/AHA guideline on the Primary Prevention of Cardiovascular Disease: Executive SummaryCirculation. 2019;140:e563–e595. DOI: 10.1161/CIR.0000000000000677 September 10, 2019 e577What is the best diet for ASCVD prevention?. ### Response: A diet high in fruits, veg-etables, and whole grains.


Instruction: What is the best diet?

Output: A diet high in fruits, veg-etables, and whole grains

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the best diet?. ### Response: A diet high in fruits, veg-etables, and whole grains.


Instruction: What are the preferred sources of protein?

Output: Fish, legumes, and poultry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the preferred sources of protein?. ### Response: Fish, legumes, and poultry.


Instruction: How should clinicians work with patients to assess their health?

Output: in partnership

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How should clinicians work with patients to assess their health?. ### Response: in partnership.


Instruction: Who should work with patients to assess their readi-ness for sustained lifestyle improvements?

Output: Clinicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should work with patients to assess their readi-ness for sustained lifestyle improvements?. ### Response: Clinicians.


Instruction: Who should encourage patients to try to achieve measurable goals and continue to monitor their progress?

Output: Clinicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should encourage patients to try to achieve measurable goals and continue to monitor their progress?. ### Response: Clinicians.


Instruction: Social determinants of ASCVD risk and their impact on the patient’s ability to prevent or treat what?

Output: risk factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Social determinants of ASCVD risk and their impact on the patient’s ability to prevent or treat what?. ### Response: risk factors.


Instruction: What must be taken into account in order for a clinician to be able to prevent or treat risk factors?

Output: social determinants of ASCVD risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must be taken into account in order for a clinician to be able to prevent or treat risk factors?. ### Response: social determinants of ASCVD risk.


Instruction: What are two things that clini-cians need to consider in order to assess patients' motivation to improve their lifestyle habits?

Output: health literacy and edu-cation levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are two things that clini-cians need to consider in order to assess patients' motivation to improve their lifestyle habits?. ### Response: health literacy and edu-cation levels.


Instruction: How is risk estimation based on group aver -ages applied to individual patients?

Output: imperfect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is risk estimation based on group aver -ages applied to individual patients?. ### Response: imperfect.


Instruction: What must the clinician balance with absolute risk of a future ASCVD event?

Output: intensity of preventive efforts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must the clinician balance with absolute risk of a future ASCVD event?. ### Response: intensity of preventive efforts.


Instruction: What must the clinician balance an understanding of a patient's estimated ASCVD risk with potential benefits and ad-verse risk from pharmacological therapy in the context of?

Output: a risk discussion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must the clinician balance an understanding of a patient's estimated ASCVD risk with potential benefits and ad-verse risk from pharmacological therapy in the context of?. ### Response: a risk discussion.


Instruction: What can inform decision-making for cholesterol-lowering or antihypertensive medication use in intermediate-risk in-dividuals?

Output: risk-enhancing factors or selective use of a coronary artery calcium measurement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can inform decision-making for cholesterol-lowering or antihypertensive medication use in intermediate-risk in-dividuals?. ### Response: risk-enhancing factors or selective use of a coronary artery calcium measurement.


Instruction: What does this primary-prevention guideline strive to provide clinicians with?

Output: the information they need

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does this primary-prevention guideline strive to provide clinicians with?. ### Response: the information they need.


Instruction: Who is the Chair-Elect of the ACC/AHA Task Force?

Output: Joshua A. Beckman

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Chair-Elect of the ACC/AHA Task Force?. ### Response: Joshua A. Beckman.


Instruction: What is Glenn N. Levine's profession?

Output: MD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Glenn N. Levine's profession?. ### Response: MD.


Instruction: N. Levine, MD, FACC, FAHA, Immediate Past Chair*; Sana M. Al-Khatib, MD; Kim K. Birtcher, PharmD, MS, AACC; Joaquin E. Cigarroa, MD: FACC; Lee A. Fleisher, MD?

Output: latky

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: N. Levine, MD, FACC, FAHA, Immediate Past Chair*; Sana M. Al-Khatib, MD; Kim K. Birtcher, PharmD, MS, AACC; Joaquin E. Cigarroa, MD: FACC; Lee A. Fleisher, MD?. ### Response: latky.


Instruction: Who is the MD, FACC; Zachary D. Goldberger?

Output: Federico Gentile

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the MD, FACC; Zachary D. Goldberger?. ### Response: Federico Gentile.


Instruction: What is Mark A. Hlatky's profession?

Output: MD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Mark A. Hlatky's profession?. ### Response: MD.