Instruction: What is the European Carotid Surgery Trial (ECST)?

Output: Randomised trial of endarterectomy for recently symptomatic carotid stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the European Carotid Surgery Trial (ECST)?. ### Response: Randomised trial of endarterectomy for recently symptomatic carotid stenosis.


Instruction: When was the ECST published?

Output: 1998

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the ECST published?. ### Response: 1998.


Instruction: What was the name of the Executive Committee for the Asymptomatic Carotisclerosis Study?

Output: MRC Asymptomatic Carotid Surgery Trial (ACST) Collaborative Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the Executive Committee for the Asymptomatic Carotisclerosis Study?. ### Response: MRC Asymptomatic Carotid Surgery Trial (ACST) Collaborative Group.


Instruction: How was the endarterectomy for asymptomatic artery stenosis performed?

Output: randomised, multicentre trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the endarterectomy for asymptomatic artery stenosis performed?. ### Response: randomised, multicentre trial.


Instruction: What is the acronym for Asymptomatic Carotid Surgery Trial?

Output: ACST

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Asymptomatic Carotid Surgery Trial?. ### Response: ACST.


Instruction: What does ASC stand for?

Output: Asymptomatic Carotid Surgery Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ASC stand for?. ### Response: Asymptomatic Carotid Surgery Trial.


Instruction: In what year did the Lancet publish a correction?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did the Lancet publish a correction?. ### Response: 2009.


Instruction: What is the name of the EV A-3S Investigators?

Output: Viguier A, Bossavy JP, Denis B, Piquet P, Garnier P, Viader F, Touzé E, Julia P, Giroud M, Krause D, Hosseini H, Becquemin JP, Hinzelin G, Houdart E, Hénon H, Neau JP, Bracard S, Onnient Y , Padovani R, Chatellier G

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the EV A-3S Investigators?. ### Response: Viguier A, Bossavy JP, Denis B, Piquet P, Garnier P, Viader F, Touzé E, Julia P, Giroud M, Krause D, Hosseini H, Becquemin JP, Hinzelin G, Houdart E, Hénon H, Neau JP, Bracard S, Onnient Y , Padovani R, Chatellier G.


Instruction: What is the name of the EV A-3S trial?

Output: Endarterectomy Versus Angioplasty in Patients with Symptomatic Severe Carotid Stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the EV A-3S trial?. ### Response: Endarterectomy Versus Angioplasty in Patients with Symptomatic Severe Carotid Stenosis.


Instruction: How long does it take for a patient to undergo endarterectomy or angioplasty in a symptomatic, severe Carotid Stenosis?

Output: 4 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take for a patient to undergo endarterectomy or angioplasty in a symptomatic, severe Carotid Stenosis?. ### Response: 4 years.


Instruction: What are the results of the Lancet Neurol. 2008?

Output: 416

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of the Lancet Neurol. 2008?. ### Response: 416.


Instruction: What is the name of the study to treat symptomatic stenoses at 2 years?

Output: Stent-Protected Angioplasty versus Carotid Endarterectomy (SPACE)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study to treat symptomatic stenoses at 2 years?. ### Response: Stent-Protected Angioplasty versus Carotid Endarterectomy (SPACE).


Instruction: What does SPACE stand for?

Output: Stent-Protected Angioplasty versus Carotid Endarterectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does SPACE stand for?. ### Response: Stent-Protected Angioplasty versus Carotid Endarterectomy.


Instruction: When was the SPACE study published?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the SPACE study published?. ### Response: 2009.


Instruction: What did Lancet Neurol. 2009:8:135 do?

Output: published correction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Lancet Neurol. 2009:8:135 do?. ### Response: published correction.


Instruction: What was the name of the study that was published in 2008?

Output: Lancet Neurol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the study that was published in 2008?. ### Response: Lancet Neurol.


Instruction: What is the name of the person who was a part of the Cohen DJ team?

Output: Cutlip DE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the person who was a part of the Cohen DJ team?. ### Response: Cutlip DE.


Instruction: What is another name for Ferguson RD?

Output: GG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for Ferguson RD?. ### Response: GG.


Instruction: Who is a member of the Blackshear JL?

Output: Silver FL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a member of the Blackshear JL?. ### Response: Silver FL.


Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al.


Instruction: What is necessary to ensure that the proper decision about treatment is made?

Output: hemodynamic catheterization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is necessary to ensure that the proper decision about treatment is made?. ### Response: hemodynamic catheterization.


Instruction: What should be done if noninvasive testing yields inconclusive data?

Output: a hemodynamic cardiac cath-eterization with direct intracardiac measurements of transvalvular pressure gradients and cardiac output measurements provides valuable clinical information

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be done if noninvasive testing yields inconclusive data?. ### Response: a hemodynamic cardiac cath-eterization with direct intracardiac measurements of transvalvular pressure gradients and cardiac output measurements provides valuable clinical information.


Instruction: What is a hemodynamic cardiac cath-eterization with direct intracardiac measurements?

Output: provides valuable clinical information

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a hemodynamic cardiac cath-eterization with direct intracardiac measurements?. ### Response: provides valuable clinical information.


Instruction: What provides valuable clinical information?

Output: hemodynamic cardiac cath-eterization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What provides valuable clinical information?. ### Response: hemodynamic cardiac cath-eterization.


Instruction: What may be underestimated when im-aging is difficult or when the Doppler beam is not aligned parallel to the direction of the high-velocity jet?

Output: Severity of stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be underestimated when im-aging is difficult or when the Doppler beam is not aligned parallel to the direction of the high-velocity jet?. ### Response: Severity of stenosis.


Instruction: What may be overestimated or underestimated if the image or Doppler data quality is suboptimal?

Output: Severity of valve regurgitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be overestimated or underestimated if the image or Doppler data quality is suboptimal?. ### Response: Severity of valve regurgitation.


Instruction: What is sometimes useful for a semiquantitative assessment of the severity of regurgitation in those instances where the noninvasive results are discordant with the physical examination?

Output: Contrast angiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is sometimes useful for a semiquantitative assessment of the severity of regurgitation in those instances where the noninvasive results are discordant with the physical examination?. ### Response: Contrast angiography.


Instruction: A major advantage of cardiac angiography is what?

Output: measurement of intracardiac pressures and pulmonary vascular resistance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A major advantage of cardiac angiography is what?. ### Response: measurement of intracardiac pressures and pulmonary vascular resistance.


Instruction: What is a major advantage of cardiac catheterization?

Output: measurement of intracardiac pressures and pulmonary vascular resistance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a major advantage of cardiac catheterization?. ### Response: measurement of intracardiac pressures and pulmonary vascular resistance.


Instruction: What can be performed in the catheterization laboratory?

Output: Diagnostic interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be performed in the catheterization laboratory?. ### Response: Diagnostic interventions.


Instruction: What is used in low-flow states?

Output: dobutamine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used in low-flow states?. ### Response: dobutamine.


Instruction: What is exercise hemodynamics in patients with discrepant symp-toms?

Output: Diagnostic interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is exercise hemodynamics in patients with discrepant symp-toms?. ### Response: Diagnostic interventions.


Instruction: A hemodynamic catheterization needs to be done with what?

Output: meticulous attention to detail

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A hemodynamic catheterization needs to be done with what?. ### Response: meticulous attention to detail.


Instruction: What type of testing will be of additional value in determining optimal therapy for a subset of patients with VHD?

Output: exercise stress testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of testing will be of additional value in determining optimal therapy for a subset of patients with VHD?. ### Response: exercise stress testing.


Instruction: Why may patients deny symptoms as they gradually limit their activity level over several years?

Output: Because of the slow, insidious rate of progression of many valve lesions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why may patients deny symptoms as they gradually limit their activity level over several years?. ### Response: Because of the slow, insidious rate of progression of many valve lesions.


Instruction: What does exercise testing help identify in patients with an equivocal history of symptoms?

Output: those who are truly symptomatic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does exercise testing help identify in patients with an equivocal history of symptoms?. ### Response: those who are truly symptomatic.


Instruction: Exercise stress testing examines the exercise capacity and what else?

Output: blood pres-sure response

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Exercise stress testing examines the exercise capacity and what else?. ### Response: blood pres-sure response.


Instruction: What is of prognostic value in patients with asymptomatic valve disease?

Output: Exercise stress testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is of prognostic value in patients with asymptomatic valve disease?. ### Response: Exercise stress testing.


Instruction: What provides further in-formation about the timing of a potential interven-tion?

Output: Exercise stress testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What provides further in-formation about the timing of a potential interven-tion?. ### Response: Exercise stress testing.


Instruction: How should exercise testing in severe VHD always be performed?

Output: by trained op-erators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How should exercise testing in severe VHD always be performed?. ### Response: by trained op-erators.


Instruction: What should always be performed by trained op-erators?

Output: exercise testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should always be performed by trained op-erators?. ### Response: exercise testing.


Instruction: What should not be neglected in patients being evaluated for VHD?

Output: Basic Principles of Medical Therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not be neglected in patients being evaluated for VHD?. ### Response: Basic Principles of Medical Therapy.


Instruction: What did Bozkurt and colleagues do on December 6, 2016 Circulation. 2016;134:e535–e578?

Output: submit a Disclosure Questionnaire

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Bozkurt and colleagues do on December 6, 2016 Circulation. 2016;134:e535–e578?. ### Response: submit a Disclosure Questionnaire.


Instruction: Who approved this statement on September 24, 2015?

Output: American Heart As-sociation Science Advisory and Coordinating Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who approved this statement on September 24, 2015?. ### Response: American Heart As-sociation Science Advisory and Coordinating Committee.


Instruction: On what date was the Coordinating Committee formed?

Output: September 24, 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On what date was the Coordinating Committee formed?. ### Response: September 24, 2015.


Instruction: On what day was the American Heart Association Ex-ecutive Committee established?

Output: October 27, 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On what day was the American Heart Association Ex-ecutive Committee established?. ### Response: October 27, 2015.


Instruction: Where is a copy of the Docu-ment available?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is a copy of the Docu-ment available?. ### Response: http://professional.heart.org/statements.


Instruction: Who can purchase additional reprints?

Output: call 843-216-2533

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who can purchase additional reprints?. ### Response: call 843-216-2533.


Instruction: Who requested that this docu-ment be cited?

Output: The American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who requested that this docu-ment be cited?. ### Response: The American Heart Association.


Instruction: What is the name of the organization that requests that this be cite?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that requests that this be cite?. ### Response: American Heart Association.


Instruction: Who represents the Heart Failure and Transplan-tation Committee of the Council on Clinical Cardiology?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who represents the Heart Failure and Transplan-tation Committee of the Council on Clinical Cardiology?. ### Response: American Heart Association.


Instruction: What are the Councils on Cardiovascular Surgery and Anesthesia?

Output: Council on Clinical Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Councils on Cardiovascular Surgery and Anesthesia?. ### Response: Council on Clinical Cardiology.


Instruction: Who is on behalf of Council on Quality and Outcomes Research?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is on behalf of Council on Quality and Outcomes Research?. ### Response: American Heart Association.


Instruction: Who conducts the peer review of AHA Scientific Statements?

Output: AHA Office of Science Operations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who conducts the peer review of AHA Scientific Statements?. ### Response: AHA Office of Science Operations.


Instruction: What are some of the comorbidities in chronic heart failure?

Output: hypertension, obesity, diabetes mellitus, hyperlipidemia, and metabolic syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the comorbidities in chronic heart failure?. ### Response: hypertension, obesity, diabetes mellitus, hyperlipidemia, and metabolic syndrome.


Instruction: Who conducts Scientific Statements?

Output: AHA Office of Science Operations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who conducts Scientific Statements?. ### Response: AHA Office of Science Operations.


Instruction: Where can you find more information on AHA statements and guidelines development?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find more information on AHA statements and guidelines development?. ### Response: http://professional.heart.org/statements.


Instruction: What is not permitted without the express permission of the AHA?

Output: Multiple copies, modification, alteration,  enhancement, and/or distribution of this document

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not permitted without the express permission of the AHA?. ### Response: Multiple copies, modification, alteration,  enhancement, and/or distribution of this document.


Instruction: Where can you find instructions for obtaining permission to distribute this document?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find instructions for obtaining permission to distribute this document?. ### Response: http://.


Instruction: Where is a link to the "Copyright Permissions Request Form" located?

Output: on the right side of the page

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is a link to the "Copyright Permissions Request Form" located?. ### Response: on the right side of the page.


Instruction: What is available at http://circ.ahajournals.org?

Output: Circulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is available at http://circ.ahajournals.org?. ### Response: Circulation.


Instruction: Who is a member of the Writing Group DisclosuresWriting Group Member Employmentresearch Grantother research SupportSpeakers’ Bureau/HonorariaExpert Witnessownership InterestConsultant/Advisory Board Other?

Output: Biykem Bozkurt

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a member of the Writing Group DisclosuresWriting Group Member Employmentresearch Grantother research SupportSpeakers’ Bureau/HonorariaExpert Witnessownership InterestConsultant/Advisory Board Other?. ### Response: Biykem Bozkurt.


Instruction: What is the name of the VA Medical Center/Baylor College of Medicine?

Output: Anita Deswal Michael E. DeBakey

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the VA Medical Center/Baylor College of Medicine?. ### Response: Anita Deswal Michael E. DeBakey.


Instruction: What is another name for Aurora Health Care Inc.?

Output: AHA Heart Failure Spotlight Series

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for Aurora Health Care Inc.?. ### Response: AHA Heart Failure Spotlight Series.


Instruction: What is the name of the guideline for chronic heart failure?

Output: NICE’s guideline on chronic heart failure in adults: diagnosis and management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the guideline for chronic heart failure?. ### Response: NICE’s guideline on chronic heart failure in adults: diagnosis and management.


Instruction: How many months should you monitor your heart failure treatment?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many months should you monitor your heart failure treatment?. ### Response: 3.


Instruction: When is the target dose of an MRA reached?

Output: Once the target, or maximum tolerated, dose of an MRA  is reached, monitor treatment monthly for 3  months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is the target dose of an MRA reached?. ### Response: Once the target, or maximum tolerated, dose of an MRA  is reached, monitor treatment monthly for 3  months.


Instruction: What is Ivabradine recommended as an option for treating for people with heart failure?

Output: chronic heart failure for people:   with New York Heart Association (NYHA) class II to IV stable chronic heart failure with systolic dysfunction and   who are in sinus rhythm with a heart rate of 75 beats per minute (bpm) or more and   who are given ivabradine in combination with standa rd therapy including beta -blocker therapy, angiotensin -converting enzyme (ACE) inhibitor and aldosterone antagonists, or when beta -blocker therapy is contraindicated or not tolerated and  52

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Ivabradine recommended as an option for treating for people with heart failure?. ### Response: chronic heart failure for people:   with New York Heart Association (NYHA) class II to IV stable chronic heart failure with systolic dysfunction and   who are in sinus rhythm with a heart rate of 75 beats per minute (bpm) or more and   who are given ivabradine in combination with standa rd therapy including beta -blocker therapy, angiotensin -converting enzyme (ACE) inhibitor and aldosterone antagonists, or when beta -blocker therapy is contraindicated or not tolerated and  52.


Instruction: What is the New York Heart Association class II?

Output: Ivabradine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the New York Heart Association class II?. ### Response: Ivabradine.


Instruction: What does NYHA stand for?

Output: New York Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does NYHA stand for?. ### Response: New York Heart Association.


Instruction: What is the heart rate of a person with NYHA class II to IV stable chronic heart failure?

Output: 75 beats per minute

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the heart rate of a person with NYHA class II to IV stable chronic heart failure?. ### Response: 75 beats per minute.


Instruction: What type of therapy is ivabradine used in combination with?

Output: standa rd therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is ivabradine used in combination with?. ### Response: standa rd therapy.


Instruction: What is ACE?

Output: angiotensin -converting enzyme

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ACE?. ### Response: angiotensin -converting enzyme.


Instruction: How long is the stabilisation period on ivaBRADINE?

Output: 4 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the stabilisation period on ivaBRADINE?. ### Response: 4 weeks.


Instruction: Ivabradinine should only be used after what period of time?

Output: 4 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Ivabradinine should only be used after what period of time?. ### Response: 4 weeks.


Instruction: What should be initiated by a heart failure specialist with access to a multidisciplinary heart failure team?

Output: Treatment with sacubitril valsartan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be initiated by a heart failure specialist with access to a multidisciplinary heart failure team?. ### Response: Treatment with sacubitril valsartan.


Instruction: After a stabilisation period of 4 weeks what should be done with ACE inhibitors, beta-blockers and aldosterone antagonists?

Output: Ivabradine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: After a stabilisation period of 4 weeks what should be done with ACE inhibitors, beta-blockers and aldosterone antagonists?. ### Response: Ivabradine.


Instruction: What should be carried out by a heart failure specialist?

Output: Dose titration and monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be carried out by a heart failure specialist?. ### Response: Dose titration and monitoring.


Instruction: What is recommended as an option for treating symptomatic chronic heart failure?

Output: Sacubitril valsartan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended as an option for treating symptomatic chronic heart failure?. ### Response: Sacubitril valsartan.


Instruction: What is valsartan recommended for treating?

Output: symptomatic chronic heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is valsartan recommended for treating?. ### Response: symptomatic chronic heart failure.


Instruction: What type of heart failure is only recommended in people with NYHA class II to IV symptoms?

Output: chronic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of heart failure is only recommended in people with NYHA class II to IV symptoms?. ### Response: chronic.


Instruction: How much is the left ventricular ejection fraction?

Output: 35% or less

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much is the left ventricular ejection fraction?. ### Response: 35% or less.


Instruction: What should be started by a heart failure specialist with access to a multidisciplinary heart failure center?

Output: Ivabradine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be started by a heart failure specialist with access to a multidisciplinary heart failure center?. ### Response: Ivabradine.


Instruction: What should be performed by the most appropriate team members?

Output: Dose titration and monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be performed by the most appropriate team members?. ### Response: Dose titration and monitoring.


Instruction: What is NICE's guideline on chronic heart failure in adults: diagnosis and management?

Output: Dose titration and monitoring should be performed by t he most appropriate team members

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE's guideline on chronic heart failure in adults: diagnosis and management?. ### Response: Dose titration and monitoring should be performed by t he most appropriate team members.


Instruction: What is not intended to affect the position of patients whose treatment with sacubitril valsartan was started within the NHS before this guidance was published?

Output: This guidance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not intended to affect the position of patients whose treatment with sacubitril valsartan was started within the NHS before this guidance was published?. ### Response: This guidance.


Instruction: What was in place for them before this guidance was published?

Output: funding arrangements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was in place for them before this guidance was published?. ### Response: funding arrangements.


Instruction: What did they and their NHS clinician consider appropriate to stop?

Output: Hydralazine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did they and their NHS clinician consider appropriate to stop?. ### Response: Hydralazine.


Instruction: Hydralazine in combination with nitrate 57.

Output: Hydralazine in combination with nitrate  57. Seek specialist advice and consider offering hydralazine in combination with nitrate (especially  if the person is of African

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hydralazine in combination with nitrate 57.. ### Response: Hydralazine in combination with nitrate  57. Seek specialist advice and consider offering hydralazine in combination with nitrate (especially  if the person is of African.


Instruction: Seek specialist advice and consider offering what?

Output: hydralazine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Seek specialist advice and consider offering what?. ### Response: hydralazine.


Instruction: What does nitrate cause?

Output: heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does nitrate cause?. ### Response: heart failure.


Instruction: What is the class of heart failure?

Output: systolic dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the class of heart failure?. ### Response: systolic dysfunction.


Instruction: Digoxin is recommended for people with what?

Output: atrial fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Digoxin is recommended for people with what?. ### Response: atrial fibrillation.


Instruction: How did dipyridamole and aspirin affect late vein-graft patency after coronary bypass operations?

Output: Effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did dipyridamole and aspirin affect late vein-graft patency after coronary bypass operations?. ### Response: Effect.


Instruction: What is the NEJM198207083070201?

Output: 15. Chesebro JH, Fuster V , Elveback LR, Clements IP, Smith HC, Holmes DR Jr, Bardsley WT, Pluth JR, Wallace RB, Puga FJ, Orszulak TA, Piehler JM, Danielson GK, Schaff HV , Frye RL. Effect of dipyridamole and aspirin on late vein-graft patency after coronary bypass operations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the NEJM198207083070201?. ### Response: 15. Chesebro JH, Fuster V , Elveback LR, Clements IP, Smith HC, Holmes DR Jr, Bardsley WT, Pluth JR, Wallace RB, Puga FJ, Orszulak TA, Piehler JM, Danielson GK, Schaff HV , Frye RL. Effect of dipyridamole and aspirin on late vein-graft patency after coronary bypass operations.


Instruction: What is the effect of coronary bypass operations on late vein-graft patency?

Output: mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of coronary bypass operations on late vein-graft patency?. ### Response: mortality.


Instruction: When was the N Engl J Med 310:209-214 published?

Output: 1984

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the N Engl J Med 310:209-214 published?. ### Response: 1984.


Instruction: What was the name of the paper published in 1984?

Output: N Engl J Med.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the paper published in 1984?. ### Response: N Engl J Med..


Instruction: What is the name of the treatment that improves early saphenous vein patency after coronary artery bypass surgery?

Output: antiplatelet therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the treatment that improves early saphenous vein patency after coronary artery bypass surgery?. ### Response: antiplatelet therapy.


Instruction: What does antiplatelet therapy do?

Output: Improvement in early saphenous vein graft patency after coronary artery bypass surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does antiplatelet therapy do?. ### Response: Improvement in early saphenous vein graft patency after coronary artery bypass surgery.


Instruction: What type of therapy was used after coronary artery bypass surgery?

Output: antiplatelet therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy was used after coronary artery bypass surgery?. ### Response: antiplatelet therapy.


Instruction: What year did Circulation.77:1324–1332?

Output: 1988

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Circulation.77:1324–1332?. ### Response: 1988.


Instruction: How long after coronary artery bypass surgery does saphenous vein graft patency last?

Output: 1 year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after coronary artery bypass surgery does saphenous vein graft patency last?. ### Response: 1 year.


Instruction: What is the effect of antiplatelet?

Output: Improvement in early saphenous vein graft patency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of antiplatelet?. ### Response: Improvement in early saphenous vein graft patency.


Instruction: What is the name of the study that examined the effects of antiplatelet therapy?

Output: Veterans Administration Cooperative Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined the effects of antiplatelet therapy?. ### Response: Veterans Administration Cooperative Study.


Instruction: What is Mangano DT's affiliation with?

Output: Perioperative Ischemia Research Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Mangano DT's affiliation with?. ### Response: Perioperative Ischemia Research Group.


Instruction: How is Aspirin related to mortality from coronary bypass surgery?

Output: resistance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is Aspirin related to mortality from coronary bypass surgery?. ### Response: resistance.


Instruction: Med. 2002;347:1309-1317. doi: 10.1056/NEJMoa020798.

Output: N Engl J

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Med. 2002;347:1309-1317. doi: 10.1056/NEJMoa020798.. ### Response: N Engl J.


Instruction: Aspirin use and survival after coronary bypass surgery. Am Heart J. 1992;123:603-608.

Output: 19

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Aspirin use and survival after coronary bypass surgery. Am Heart J. 1992;123:603-608.. ### Response: 19.


Instruction: What is the name of the study that examined the effects of percutaneous revascularization on long-term mortality in patients treated with surgical or percuta-neous procedures?

Output: Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery (SYNTAX) trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined the effects of percutaneous revascularization on long-term mortality in patients treated with surgical or percuta-neous procedures?. ### Response: Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery (SYNTAX) trial.


Instruction: What is SYNTAX?

Output: Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SYNTAX?. ### Response: Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery.


Instruction: When was the Eur Heart J33:3105-3113 published?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Eur Heart J33:3105-3113 published?. ### Response: 2012.


Instruction: What is the name of the meta-analysis of optimal antithrombotic therapy following aortocoronary bypass?

Output: Veterans Administration Cooperative Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis of optimal antithrombotic therapy following aortocoronary bypass?. ### Response: Veterans Administration Cooperative Study.


Instruction: What is a meta-analysis of therapy following aortocoronary bypass?

Output: Optimal antithrombotic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a meta-analysis of therapy following aortocoronary bypass?. ### Response: Optimal antithrombotic.


Instruction: What is the name of the study that evaluated aspirin therapy after coronary surgery?

Output: Indirect comparison meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated aspirin therapy after coronary surgery?. ### Response: Indirect comparison meta-analysis.


Instruction: When did the BMJ issue 327:1309?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the BMJ issue 327:1309?. ### Response: 2003.


Instruction: What does aspirin resistance after coronary artery bypass graft-ing cause?

Output: mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does aspirin resistance after coronary artery bypass graft-ing cause?. ### Response: mortality.


Instruction: What is the name of the study that investigated aspirine resistance after a coronary heart bypass?

Output: Veterans Administration Cooperative Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated aspirine resistance after a coronary heart bypass?. ### Response: Veterans Administration Cooperative Study.


Instruction: When was the J Thorac Cardiovasc Surg published?

Output: 1993

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Thorac Cardiovasc Surg published?. ### Response: 1993.


Instruction: What is clinical stability defined by?

Output: the absence of low output, hypotension, persistent tachycardia, apparent shock, high-grade ventricular or symptomatic supraventricular tachyarrhythmias, and spontaneous recurrent ischemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is clinical stability defined by?. ### Response: the absence of low output, hypotension, persistent tachycardia, apparent shock, high-grade ventricular or symptomatic supraventricular tachyarrhythmias, and spontaneous recurrent ischemia.


Instruction: What indicates Class of Recommendation; HF, heart failure; LOE, Level of Evidence; MI, myocardial infarction; PCI, percutaneous coronary intervention?

Output: COR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates Class of Recommendation; HF, heart failure; LOE, Level of Evidence; MI, myocardial infarction; PCI, percutaneous coronary intervention?. ### Response: COR.


Instruction: What is MI?

Output: myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is MI?. ### Response: myocardial infarction.


Instruction: What is PCI?

Output: percutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PCI?. ### Response: percutaneous coronary intervention.


Instruction: When was Evidence downloaded from http://ahajournals.org?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Evidence downloaded from http://ahajournals.org?. ### Response: April 28, 2023.


Instruction: What is the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al.


Instruction: What is Idarucizumab for for dabigatran reversal?

Output: full cohort analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Idarucizumab for for dabigatran reversal?. ### Response: full cohort analysis.


Instruction: What is Idarucizumab used for?

Output: dabigatran reversal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Idarucizumab used for?. ### Response: dabigatran reversal.


Instruction: What is Andexanet alfa used for for the reversal of?

Output: factor Xa inhibitor activity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Andexanet alfa used for for the reversal of?. ### Response: factor Xa inhibitor activity.


Instruction: What drug is used for bleeding associated with factor Xa inhibitors?

Output: andex-anet alfa

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug is used for bleeding associated with factor Xa inhibitors?. ### Response: andex-anet alfa.


Instruction: What is the name of the drug used for acute major bleeding?

Output: Andexanet alfa

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used for acute major bleeding?. ### Response: Andexanet alfa.


Instruction: How many studies have been conducted on andexanet alfa?

Output: 511–20

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies have been conducted on andexanet alfa?. ### Response: 511–20.


Instruction: What is a factor Xa inhibitor?

Output: andex-anet alfa

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a factor Xa inhibitor?. ### Response: andex-anet alfa.


Instruction: What is the name of the drug used for dabigatran rever -sal?

Output: Idarucizumab

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used for dabigatran rever -sal?. ### Response: Idarucizumab.


Instruction: How many patients were treated with Idarucizumab?

Output: 5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with Idarucizumab?. ### Response: 5.


Instruction: What is the biochemical evidence of rebound after cessation of oral anticoagulant therapy?

Output: Genewein U, Haeberli A, Straub PW, et al. Rebound after cessation of oral anticoagulant therapy: the biochemical evidence. Br J Haematol. 1996;92:479–85

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the biochemical evidence of rebound after cessation of oral anticoagulant therapy?. ### Response: Genewein U, Haeberli A, Straub PW, et al. Rebound after cessation of oral anticoagulant therapy: the biochemical evidence. Br J Haematol. 1996;92:479–85.


Instruction: What was the 1996 issue of Br J Haematol?

Output: 92:479–85

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 1996 issue of Br J Haematol?. ### Response: 92:479–85.


Instruction: What did the American College of Cardiology Task Force on Ex-pert Consensus Decision Pathways report on?

Output: management of bleeding in patients on oral antico-agulants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the American College of Cardiology Task Force on Ex-pert Consensus Decision Pathways report on?. ### Response: management of bleeding in patients on oral antico-agulants.


Instruction: What is associated with decreased mortality in patients with severe bleeding under vitamin K?

Output: complex concentrate and vitamin K

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with decreased mortality in patients with severe bleeding under vitamin K?. ### Response: complex concentrate and vitamin K.


Instruction: What did the EPAHK study show about vitamin K an-tagonist treatment?

Output: decreased mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the EPAHK study show about vitamin K an-tagonist treatment?. ### Response: decreased mortality.


Instruction: What is the name of the study that examined the effect of vitamin K on mortality in patients with severe bleeding?

Output: EPAHK study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined the effect of vitamin K on mortality in patients with severe bleeding?. ### Response: EPAHK study.


Instruction: In what year did the Ann Pharmacother issue 46:1617–26?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did the Ann Pharmacother issue 46:1617–26?. ### Response: 2012.


Instruction: What is the name of the French clinical practice guidelines on the management of patients on vitamin K antagonists in at-risk situ-ations?

Output: Pernod G, Godiér A, Gozalo C, et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the French clinical practice guidelines on the management of patients on vitamin K antagonists in at-risk situ-ations?. ### Response: Pernod G, Godiér A, Gozalo C, et al.


Instruction: What are the terms for overdose, risk of bleeding, and active bleeding?

Output: at-risk situ-ations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the terms for overdose, risk of bleeding, and active bleeding?. ### Response: at-risk situ-ations.


Instruction: What does Thromb Res. 2010 do?

Output: vitamin K antagonists in at-risk situ-ations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Thromb Res. 2010 do?. ### Response: vitamin K antagonists in at-risk situ-ations.


Instruction: What does low-dose oral vitamin K do for excessive anticoagulation?

Output: Correction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does low-dose oral vitamin K do for excessive anticoagulation?. ### Response: Correction.


Instruction: When was the Ann Intern Med 126:959-62 published?

Output: 1997

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Ann Intern Med 126:959-62 published?. ### Response: 1997.


Instruction: What are the safety profiles of intravenous vitamin K and fresh frozen plasma as treatment of warfarin-related over-anticoagulation in patients with mechanical heart valves?

Output: efficacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the safety profiles of intravenous vitamin K and fresh frozen plasma as treatment of warfarin-related over-anticoagulation in patients with mechanical heart valves?. ### Response: efficacy.


Instruction: What is the name of the systematic review and meta-analysis of vitamin K for reversal of exces-sive vitamin K antagonist anticoagulation?

Output: Khatib R, Ludwikowska M, Witt DM, et al. Vitamin K for reversal of exces-sive vitamin K antagonist anticoagulation: a systematic review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta-analysis of vitamin K for reversal of exces-sive vitamin K antagonist anticoagulation?. ### Response: Khatib R, Ludwikowska M, Witt DM, et al. Vitamin K for reversal of exces-sive vitamin K antagonist anticoagulation: a systematic review.


Instruction: What is vitamin K antagonist anticoagulation?

Output: reversal of exces-sive

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is vitamin K antagonist anticoagulation?. ### Response: reversal of exces-sive.


Instruction: What is blood adv. 2019;3:789–96.11.5.

Output: Vitamin K

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is blood adv. 2019;3:789–96.11.5.. ### Response: Vitamin K.


Instruction: What are thromboembolic events with prosthetic valves?

Output: Excessive Anticoagulation and Serious Bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are thromboembolic events with prosthetic valves?. ### Response: Excessive Anticoagulation and Serious Bleeding.


Instruction: What are the most common causes of idiopathic VA?

Output: focal mechanism of triggered activity or abnormal automaticity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the most common causes of idiopathic VA?. ### Response: focal mechanism of triggered activity or abnormal automaticity.


Instruction: What are some of the reentrant LV tachycardias due to?

Output: reentry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the reentrant LV tachycardias due to?. ### Response: reentry.


Instruction: The clinical manifestations of what type of VA are highly variable?

Output: idiopathic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The clinical manifestations of what type of VA are highly variable?. ### Response: idiopathic.


Instruction: What type of heart disease is evaluated on discovery?

Output: structural

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of heart disease is evaluated on discovery?. ### Response: structural.


Instruction: What is warranted on discovery of structural heart disease?

Output: an evaluation for structural heart disease is warranted with physical examination, an ECG, and imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is warranted on discovery of structural heart disease?. ### Response: an evaluation for structural heart disease is warranted with physical examination, an ECG, and imaging.


Instruction: If the patient has a family history of SCD, what is guided by?

Output: symptoms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: If the patient has a family history of SCD, what is guided by?. ### Response: symptoms.


Instruction: What are assessment and treatment guided by?

Output: symptoms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are assessment and treatment guided by?. ### Response: symptoms.


Instruction: What is sufficient if the patient is asymptomatic and does not have evidence of a cardiac channelopathy?

Output: reassurance as to the benign nature

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is sufficient if the patient is asymptomatic and does not have evidence of a cardiac channelopathy?. ### Response: reassurance as to the benign nature.


Instruction: If the arrhythmia is suspected of being sufficiently frequent to cause ventricular dysfunction over time, periodic follow-up with reassessment of what is needed?

Output: ventricular function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: If the arrhythmia is suspected of being sufficiently frequent to cause ventricular dysfunction over time, periodic follow-up with reassessment of what is needed?. ### Response: ventricular function.


Instruction: What is warranted with periodic follow-up with reassessment of ventricular function?

Output: If the arrhythmia is suspected of being suf-ficiently frequent to cause ventricular dysfunction over time

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is warranted with periodic follow-up with reassessment of ventricular function?. ### Response: If the arrhythmia is suspected of being suf-ficiently frequent to cause ventricular dysfunction over time.


Instruction: For mild symp-toms, avoidance of aggravating factors such as excessive consumption of caffeine or sympathomimetic agents may be sufficient.

Output: Therapy with a beta blocker or non-dihydropyradine calcium channel blocker reduces symp-toms for some patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For mild symp-toms, avoidance of aggravating factors such as excessive consumption of caffeine or sympathomimetic agents may be sufficient.. ### Response: Therapy with a beta blocker or non-dihydropyradine calcium channel blocker reduces symp-toms for some patients.


Instruction: Therapy with a beta blocker or non-dihydropyradine calcium channel blocker reduces what for some patients?

Output: symp-toms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Therapy with a beta blocker or non-dihydropyradine calcium channel blocker reduces what for some patients?. ### Response: symp-toms.


Instruction: What does non-dihydropyradine calcium channel blocker reduce for some patients?

Output: symp-toms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does non-dihydropyradine calcium channel blocker reduce for some patients?. ### Response: symp-toms.


Instruction: Why are Class I antiarrhythmic medica-tions generally avoided?

Output: concerns for adverse effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why are Class I antiarrhythmic medica-tions generally avoided?. ### Response: concerns for adverse effects.


Instruction: What can be a highly effective treatment for patients who require arrhythmia suppression?

Output: catheter ablation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be a highly effective treatment for patients who require arrhythmia suppression?. ### Response: catheter ablation.


Instruction: What can be a highly effective treatment?

Output: catheter ablation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be a highly effective treatment?. ### Response: catheter ablation.


Instruction: What is the most common site of origin for idiopathic VA?

Output: right ventricular outflow tract

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common site of origin for idiopathic VA?. ### Response: right ventricular outflow tract.


Instruction: What is RVOT?

Output: right ventricular outflow tract

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is RVOT?. ### Response: right ventricular outflow tract.


Instruction: The ostium of the LV is comprised of the oval opening of what?

Output: the LV

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The ostium of the LV is comprised of the oval opening of what?. ### Response: the LV.


Instruction: What is attached anteriorly and the left atrium attached posteriorly?

Output: the aorta

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is attached anteriorly and the left atrium attached posteriorly?. ### Response: the aorta.


Instruction: What provides a good indication of the type of ap-proach required and the likelihood of success and risks?

Output: QRS morphology of the VA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What provides a good indication of the type of ap-proach required and the likelihood of success and risks?. ### Response: QRS morphology of the VA.


Instruction: Ablation failure is often related to the absence of what?

Output: the VA for mapping at the time of the procedure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Ablation failure is often related to the absence of what?. ### Response: the VA for mapping at the time of the procedure.


Instruction: What is often related to the absence of the VA for mapping at the time of the procedure?

Output: Ablation failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is often related to the absence of the VA for mapping at the time of the procedure?. ### Response: Ablation failure.


Instruction: What sometimes produces sustained monomorphic VT?

Output: Ablation failure is often related to the absence of the VA for mapping at the time of the procedure, or origin of the VA in an inaccessible region of the heart. These foci

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What sometimes produces sustained monomorphic VT?. ### Response: Ablation failure is often related to the absence of the VA for mapping at the time of the procedure, or origin of the VA in an inaccessible region of the heart. These foci.


Instruction: How many patients were in a randomized, double-blind, placebo-con-trolled study?

Output: 52

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were in a randomized, double-blind, placebo-con-trolled study?. ### Response: 52.


Instruction: What did atenolol significantly decrease in a randomized, double-blind, placebo-con-trolled study of 52 patients with symptomatic VA?

Output: symptom frequency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did atenolol significantly decrease in a randomized, double-blind, placebo-con-trolled study of 52 patients with symptomatic VA?. ### Response: symptom frequency.


Instruction: What was the mean PVC count of the 52 patients?

Output: 21 407±1740 beats per 24 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean PVC count of the 52 patients?. ### Response: 21 407±1740 beats per 24 hours.


Instruction: How many beats per 24 hours did the patients have?

Output: 21 407±1740

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many beats per 24 hours did the patients have?. ### Response: 21 407±1740.


Instruction: Which drug significantly decreased symptom frequency?

Output: atenolol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which drug significantly decreased symptom frequency?. ### Response: atenolol.


Instruction: What was the effect of antiarrhythmic medications versus catheter ablation on RVOT VA?

Output: modest efficacy to suppress RVOT VA although with a far higher rate of recurrence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the effect of antiarrhythmic medications versus catheter ablation on RVOT VA?. ### Response: modest efficacy to suppress RVOT VA although with a far higher rate of recurrence.


Instruction: What is the effect on PVC count or average heart rate?

Output: no

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect on PVC count or average heart rate?. ### Response: no.


Instruction: How often is atropine given every 15 minutes?

Output: 0.1 to 0.2 mg IV every 15 minutes when indicated to reverse the narcotic effects of morphine, and atropine 0.5 to 1.5 mg IV

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often is atropine given every 15 minutes?. ### Response: 0.1 to 0.2 mg IV every 15 minutes when indicated to reverse the narcotic effects of morphine, and atropine 0.5 to 1.5 mg IV.


Instruction: What may be given to counter excessive morphine-related bradycardia?

Output: atropine 0.5 to 1.5 mg IV

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be given to counter excessive morphine-related bradycardia?. ### Response: atropine 0.5 to 1.5 mg IV.


Instruction: Nonsteroidal anti-inflammatory drugs and COX-2 inhibitors may be associated with an increased risk of death, reinfarction, car-diac rupture, hypertension, renal insufficiency, and what else?

Output: HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Nonsteroidal anti-inflammatory drugs and COX-2 inhibitors may be associated with an increased risk of death, reinfarction, car-diac rupture, hypertension, renal insufficiency, and what else?. ### Response: HF.


Instruction: What are contraindicated in patients with STEMI?

Output: oidal anti-inflammatory drugs and COX-2 inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are contraindicated in patients with STEMI?. ### Response: oidal anti-inflammatory drugs and COX-2 inhibitors.


Instruction: What is contraindicated in patients with STEMI?

Output: oidal anti-inflammatory drugs and COX-2 inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is contraindicated in patients with STEMI?. ### Response: oidal anti-inflammatory drugs and COX-2 inhibitors.


Instruction: What should not be initiated in the acute phase and should be discontinued in patients using them before hospitalization?

Output: Nonsteroidal anti-inflammatory drugs and COX-2 inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not be initiated in the acute phase and should be discontinued in patients using them before hospitalization?. ### Response: Nonsteroidal anti-inflammatory drugs and COX-2 inhibitors.


Instruction: Complications After STEMI9.1. What is recommended in suitable patients with cardiogenic shock?

Output: Emergency revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Complications After STEMI9.1. What is recommended in suitable patients with cardiogenic shock?. ### Response: Emergency revascularization.


Instruction: What is recommended in suitable patients with cardiogenic shock due to pump failure after STEMI?

Output: Emergency revascularization with either PCI or CABG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended in suitable patients with cardiogenic shock due to pump failure after STEMI?. ### Response: Emergency revascularization with either PCI or CABG.


Instruction: What should be administered to patients who are unsuitable candidates for fibrinolytic therapy?

Output: PCI or CABG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be administered to patients who are unsuitable candidates for fibrinolytic therapy?. ### Response: PCI or CABG.


Instruction: What can be useful for patients with cardiogenic shock after STEMI who don't quickly stabilize with pharmacological therapy?

Output: Emergency revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be useful for patients with cardiogenic shock after STEMI who don't quickly stabilize with pharmacological therapy?. ### Response: Emergency revascularization.


Instruction: What is IABP coun-ter pulsation?

Output: intra-aortic balloon pump

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is IABP coun-ter pulsation?. ### Response: intra-aortic balloon pump.


Instruction: What does not quickly stabilize with pharmacological therapy?

Output: cardiogenic shock

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not quickly stabilize with pharmacological therapy?. ### Response: cardiogenic shock.


Instruction: What may be considered in patients with refractory cardio-genic shock?

Output: Alternative LV assist devices for circulatory support

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered in patients with refractory cardio-genic shock?. ### Response: Alternative LV assist devices for circulatory support.


Instruction: What is the onset of cardiogenic shock due to mechanical complications after STEMI?

Output: bimodal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the onset of cardiogenic shock due to mechanical complications after STEMI?. ### Response: bimodal.


Instruction: What percentage of pump failure cases occur within 24 hours?

Output: 15%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of pump failure cases occur within 24 hours?. ### Response: 15%.


Instruction: What percentage of pump failure cases occur at time of presentation?

Output: 15%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of pump failure cases occur at time of presentation?. ### Response: 15%.


Instruction: What is the preferred reperfusion strategy for patients with STEMI and shock due to pump failure?

Output: Revascularization with timely PCI or CABG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the preferred reperfusion strategy for patients with STEMI and shock due to pump failure?. ### Response: Revascularization with timely PCI or CABG.


Instruction: What is perhaps the only clinical scenario in which revascularization of significant stenoses in noninfarct arter -ies can be justified?

Output: Shock or severe HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is perhaps the only clinical scenario in which revascularization of significant stenoses in noninfarct arter -ies can be justified?. ### Response: Shock or severe HF.


Instruction: In the SHOCK trial, mortality rates at 6 and 1 year were significantly lower in patients allocated to what?

Output: emergency revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the SHOCK trial, mortality rates at 6 and 1 year were significantly lower in patients allocated to what?. ### Response: emergency revascularization.


Instruction: What was significantly lower in patients allocated to emergency revascularization than in patients who received immediate medical stabilization?

Output: mortality rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was significantly lower in patients allocated to emergency revascularization than in patients who received immediate medical stabilization?. ### Response: mortality rates.


Instruction: How much did Rosendorff et al Treatment of Hypertension in Patients With CAD 1389 increase for every 10-mm Hg decrease in BP at presentation?

Output: ≈ 20%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much did Rosendorff et al Treatment of Hypertension in Patients With CAD 1389 increase for every 10-mm Hg decrease in BP at presentation?. ### Response: ≈ 20%.


Instruction: What is the Thrombolysis in Myocardial Infarction risk score for UA/NSTEMI?

Output: SBP <100 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Thrombolysis in Myocardial Infarction risk score for UA/NSTEMI?. ### Response: SBP <100 mm Hg.


Instruction: What was a powerful contributor to the model of STEMI?

Output: SBP <100 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a powerful contributor to the model of STEMI?. ### Response: SBP <100 mm Hg.


Instruction: What did hypertension not contribute to?

Output: bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did hypertension not contribute to?. ### Response: bleeding.


Instruction: GUSTO IIb and Platelet Glycoprotein IIb/IIIa in what type of angina?

Output: Unstable

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: GUSTO IIb and Platelet Glycoprotein IIb/IIIa in what type of angina?. ### Response: Unstable.


Instruction: What is the name of the PURSUIT trial?

Output: Unstable Angina: Receptor Suppression Using Integrilin Therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the PURSUIT trial?. ### Response: Unstable Angina: Receptor Suppression Using Integrilin Therapy.


Instruction: What was strongly associated with 48-hour and 30-day mortality?

Output: a very low SBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was strongly associated with 48-hour and 30-day mortality?. ### Response: a very low SBP.


Instruction: How much difference in mortality was there between patients who had a high SBP (>140 mm Hg) and those who had low SBP?

Output: little

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much difference in mortality was there between patients who had a high SBP (>140 mm Hg) and those who had low SBP?. ### Response: little.


Instruction: What did the NCDR ACTION analysis of  80 000 patients with MI show?

Output: protective

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the NCDR ACTION analysis of  80 000 patients with MI show?. ### Response: protective.


Instruction: What was the normal or prehypertensive range of SBP?

Output: 121–140 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the normal or prehypertensive range of SBP?. ### Response: 121–140 mm Hg.


Instruction: How many patients with MI had ACTION analysis?

Output: ≈ 80 000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with MI had ACTION analysis?. ### Response: ≈ 80 000.


Instruction: Uncontrolled hypertension does not appear to increase in-hospital mortality in patients with what?

Output: ACS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Uncontrolled hypertension does not appear to increase in-hospital mortality in patients with what?. ### Response: ACS.


Instruction: What is a major risk factor for intracranial hemorrhage?

Output: uncontrolled hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a major risk factor for intracranial hemorrhage?. ### Response: uncontrolled hypertension.


Instruction: What is a U-shaped association between BP and in-hospital bleeding observed?

Output: excess bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a U-shaped association between BP and in-hospital bleeding observed?. ### Response: excess bleeding.


Instruction: What is excess bleeding observed for both patients with hypertension and those with hypotension?

Output: a U-shaped association between BP and in-hospital bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is excess bleeding observed for both patients with hypertension and those with hypotension?. ### Response: a U-shaped association between BP and in-hospital bleeding.


Instruction: What did Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the ACC/AHA Guidelines (CRUSADE) Registry?

Output: Can Rapid Risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the ACC/AHA Guidelines (CRUSADE) Registry?. ### Response: Can Rapid Risk.


Instruction: What were the lowest bleeding rates in patients with admisssion SBP between 120 and 180 mm Hg?

Output: 184

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the lowest bleeding rates in patients with admisssion SBP between 120 and 180 mm Hg?. ### Response: 184.


Instruction: How did bleeding rates increase progresively with BPs above and below these ranges?

Output: excess bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did bleeding rates increase progresively with BPs above and below these ranges?. ### Response: excess bleeding.


Instruction: What is the NCDR ACTION Registry Bleeding Risk Score?

Output: zero points are awarded for an SBP of 141 to 170 mm Hg on arrival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the NCDR ACTION Registry Bleeding Risk Score?. ### Response: zero points are awarded for an SBP of 141 to 170 mm Hg on arrival.


Instruction: How many points are given for SBP >200 mm Hg?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many points are given for SBP >200 mm Hg?. ### Response: 2.


Instruction: What did not emerge as indepen-dently associated with bleeding in the ACUITY and Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction trials?

Output: BP variables

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did not emerge as indepen-dently associated with bleeding in the ACUITY and Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction trials?. ### Response: BP variables.


Instruction: What makes it difficult to determine the impact of treating hypertension during an acute ACS episode?

Output: important limitations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What makes it difficult to determine the impact of treating hypertension during an acute ACS episode?. ### Response: important limitations.


Instruction: All of the data are what?

Output: observational

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: All of the data are what?. ### Response: observational.


Instruction: What is likely to explain some, if not most, of the association between lower BP and mortality after ACS?

Output: residual confounding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is likely to explain some, if not most, of the association between lower BP and mortality after ACS?. ### Response: residual confounding.


Instruction: What is the association between lower BP and mortality after ACS?

Output: adverse

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association between lower BP and mortality after ACS?. ### Response: adverse.


Instruction: What is available from BP values within or near the normal range?

Output: very limited information

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is available from BP values within or near the normal range?. ### Response: very limited information.


Instruction: What is the name of the book published by NICE 2018?

Output: Chronic Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the book published by NICE 2018?. ### Response: Chronic Heart Failure.


Instruction: What may not have been included in the study?

Output: other less relevant studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may not have been included in the study?. ### Response: other less relevant studies.


Instruction: Where is the economic evaluation checklist located?

Output: NICE guidelines manual

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the economic evaluation checklist located?. ### Response: NICE guidelines manual.


Instruction: What is the health economics review protocol located in?

Output: appendix  B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the health economics review protocol located in?. ### Response: appendix  B.


Instruction: What was presented to the committee to inform the possible economic implications of the recommendations?

Output: relevant UK NHS unit costs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was presented to the committee to inform the possible economic implications of the recommendations?. ### Response: relevant UK NHS unit costs.


Instruction: What were the relevant UK NHS unit costs related to?

Output: compared interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the relevant UK NHS unit costs related to?. ### Response: compared interventions.


Instruction: What did NICE use to summarise the cost and cost-effectiveness estima tes for the included health economic studies in each review chapter?

Output: health economic evidence profile tables

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did NICE use to summarise the cost and cost-effectiveness estima tes for the included health economic studies in each review chapter?. ### Response: health economic evidence profile tables.


Instruction: What shows an assessment of applicability and methodological quality for each economic study?

Output: The health economic evidence profile

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What shows an assessment of applicability and methodological quality for each economic study?. ### Response: The health economic evidence profile.


Instruction: What did the health economist use to make these assessments?

Output: the economic evaluation checklist from the NICE guidelines manual

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the health economist use to make these assessments?. ### Response: the economic evaluation checklist from the NICE guidelines manual.


Instruction: Where did the economic evaluation checklist come from?

Output: NICE guidelines manual

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where did the economic evaluation checklist come from?. ### Response: NICE guidelines manual.


Instruction: What is the economic evaluation checklist from the NICE guidelines manual?

Output: appendix  H

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the economic evaluation checklist from the NICE guidelines manual?. ### Response: appendix  H.


Instruction: What does ICER stand for?

Output: incremental cost -effectiveness ratio

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ICER stand for?. ### Response: incremental cost -effectiveness ratio.


Instruction: What was included in the profile when a non -UK study was included?

Output: the results were converted into pounds sterling using the approp riate purchasing power parity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was included in the profile when a non -UK study was included?. ### Response: the results were converted into pounds sterling using the approp riate purchasing power parity.


Instruction: How were the results converted into pounds sterling using the approp riate purchasing power parity?

Output: When  a non -UK study was included in the profile

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How were the results converted into pounds sterling using the approp riate purchasing power parity?. ### Response: When  a non -UK study was included in the profile.


Instruction: What is the value of sterling using the purchasing power parity?

Output: pounds

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the value of sterling using the purchasing power parity?. ### Response: pounds.


Instruction: Table 8: Content of NICE health economic evidence profile

Output: assessment of applicability and methodological quality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Table 8: Content of NICE health economic evidence profile. ### Response: assessment of applicability and methodological quality.


Instruction: What is an assessment of the applicability of the study to the current NHS situation and NICE decision-making?

Output: Applicability

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an assessment of the applicability of the study to the current NHS situation and NICE decision-making?. ### Response: Applicability.


Instruction: What is unlikely to change the conclusions about cost effectiveness?

Output: Directly applicable – the study meets all applicability criteria, or fails to meet 1 or more applicability criteria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is unlikely to change the conclusions about cost effectiveness?. ### Response: Directly applicable – the study meets all applicability criteria, or fails to meet 1 or more applicability criteria.


Instruction: What is not applicable if the study fails to meet 1 or more applicability criteria?

Output: cost  effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not applicable if the study fails to meet 1 or more applicability criteria?. ### Response: cost  effectiveness.


Instruction: What does not apply if the study fails to meet 1 or more of the applicability criteria?

Output: cost  effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not apply if the study fails to meet 1 or more of the applicability criteria?. ### Response: cost  effectiveness.


Instruction: What would usually be excluded from the review?

Output: studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would usually be excluded from the review?. ### Response: studies.


Instruction: What was excluded from the review?

Output: health economic studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was excluded from the review?. ### Response: health economic studies.


Instruction: What is an assessment of methodological quality of the study?

Output: Limitations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an assessment of methodological quality of the study?. ### Response: Limitations.


Instruction: How is Domiciliary oxygen therapy used in people with advanced heart failure?

Output: repeated long term use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is Domiciliary oxygen therapy used in people with advanced heart failure?. ### Response: repeated long term use.


Instruction: What is the ISBN number of the book that contains the book Recommendations No recommendation?

Output: 978 -1-4731 -3093 -7 424

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ISBN number of the book that contains the book Recommendations No recommendation?. ### Response: 978 -1-4731 -3093 -7 424.


Instruction: In people with heart failure and significant changes in their health, what is the name of the drug that can be used to treat heart failure patients?

Output: Domiciliary oxygen therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In people with heart failure and significant changes in their health, what is the name of the drug that can be used to treat heart failure patients?. ### Response: Domiciliary oxygen therapy.


Instruction: What is the clinical and cost effectiveness of oral, subcutaneous and intravenous diuretic therapy in the community?

Output: whether funding a home or community based IV diuretics service was safe, clinically effecti ve, cost effective and well received by patients and carers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the clinical and cost effectiveness of oral, subcutaneous and intravenous diuretic therapy in the community?. ### Response: whether funding a home or community based IV diuretics service was safe, clinically effecti ve, cost effective and well received by patients and carers.


Instruction: What was safe, clinical effecti ve, and cost effective in people with advanced heart failure?

Output: funding a home or community based IV diuretics service

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was safe, clinical effecti ve, and cost effective in people with advanced heart failure?. ### Response: funding a home or community based IV diuretics service.


Instruction: What was safe, effective, cost effective and well received by patients and carers?

Output: funding a home or community based IV diuretics service

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was safe, effective, cost effective and well received by patients and carers?. ### Response: funding a home or community based IV diuretics service.


Instruction: The committee noted that this study did not meet the methodological threshold for inclusion within what review?

Output: not randomised

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committee noted that this study did not meet the methodological threshold for inclusion within what review?. ### Response: not randomised.


Instruction: What did the committee note was not randomised?

Output: this study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee note was not randomised?. ### Response: this study.


Instruction: How did people with advanced disease respond to domiciliary oxygen therapy?

Output: Breathlessness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did people with advanced disease respond to domiciliary oxygen therapy?. ### Response: Breathlessness.


Instruction: What is a common symptom in advanced heart failure?

Output: Breathlessness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a common symptom in advanced heart failure?. ### Response: Breathlessness.


Instruction: What is the current British Thoracic Society guideline s (2015)142?

Output: for home oxygen state that only hypoxa

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the current British Thoracic Society guideline s (2015)142?. ### Response: for home oxygen state that only hypoxa.


Instruction: What is a clinical pulmonary oedema?

Output: pulmonary hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a clinical pulmonary oedema?. ### Response: pulmonary hypertension.