Instruction: What have the American Diabetes Association and European Association for the Study of Diabetes revised their algorithms for?

Output: the man-agement of T2D

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have the American Diabetes Association and European Association for the Study of Diabetes revised their algorithms for?. ### Response: the man-agement of T2D.


Instruction: What does the Diabetes Association and European Association for the Study of Diabetes recommend as first-line therapy?

Output: metformin and comprehensive life-style optimization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Diabetes Association and European Association for the Study of Diabetes recommend as first-line therapy?. ### Response: metformin and comprehensive life-style optimization.


Instruction: What should be added to metformin in patients with established ASCVD?

Output: GLP-1 receptor agonist therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be added to metformin in patients with established ASCVD?. ### Response: GLP-1 receptor agonist therapy.


Instruction: When should GLP-1 receptor agonist therapy be added?

Output: when prevention of further vascular events is the priority

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When should GLP-1 receptor agonist therapy be added?. ### Response: when prevention of further vascular events is the priority.


Instruction: What should be added to metformin independently of baseline HbA1c?

Output: GLP-1 receptor agonist therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be added to metformin independently of baseline HbA1c?. ### Response: GLP-1 receptor agonist therapy.


Instruction: When concern for heart failure or chronic kidney disease predominates, what is recommended?

Output: addition of a sodium-glucose cotransporter 2 inhibitor to metformin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When concern for heart failure or chronic kidney disease predominates, what is recommended?. ### Response: addition of a sodium-glucose cotransporter 2 inhibitor to metformin.


Instruction: What has implications for the care of patients with diabetes and ischemic stroke?

Output: developments in manage-ment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has implications for the care of patients with diabetes and ischemic stroke?. ### Response: developments in manage-ment.


Instruction: What should clinicians help patients decide if a GLP-1 receptor agonist or a sodium-glucose cotransporter 2 inhibitor is right for them?

Output: shared  decision-making

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should clinicians help patients decide if a GLP-1 receptor agonist or a sodium-glucose cotransporter 2 inhibitor is right for them?. ### Response: shared  decision-making.


Instruction: What is risk for future vascular disease?

Output: only one consid-eration in selecting among available diabetes med-ications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is risk for future vascular disease?. ### Response: only one consid-eration in selecting among available diabetes med-ications.


Instruction: What is one of the consid-erations in choosing among available diabetes med-ications?

Output: Risk for future vascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the consid-erations in choosing among available diabetes med-ications?. ### Response: Risk for future vascular disease.


Instruction: What is another consi-deration in selecting among available diabetic medications?

Output: Risk for future vascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another consi-deration in selecting among available diabetic medications?. ### Response: Risk for future vascular disease.


Instruction: How is optimal management of T2D achieved with a multidimensional approach?

Output: (1) med-ical nutritional therapy; (2) lifestyle counseling (for physical activity, weight loss, smoking cessation, etc); (3) diabetes self-management, education, and support; and (4) medication therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is optimal management of T2D achieved with a multidimensional approach?. ### Response: (1) med-ical nutritional therapy; (2) lifestyle counseling (for physical activity, weight loss, smoking cessation, etc); (3) diabetes self-management, education, and support; and (4) medication therapy.


Instruction: What is achieved with a multidimensional approach?

Output: Optimal management of T2D

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is achieved with a multidimensional approach?. ### Response: Optimal management of T2D.


Instruction: What can be helpful for patients with overweight or obesity?

Output: intensive behavioral counseling for weight loss in medical nutritional therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be helpful for patients with overweight or obesity?. ### Response: intensive behavioral counseling for weight loss in medical nutritional therapy.


Instruction: What can be included in medical nutritional therapy for weight loss?

Output: intensive behavioral counseling

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be included in medical nutritional therapy for weight loss?. ### Response: intensive behavioral counseling.


Instruction: What is highly responsive to weight opti-mization in most patients?

Output: T2D

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is highly responsive to weight opti-mization in most patients?. ### Response: T2D.


Instruction: Weight loss can result in what for some patients and reduced medication use in most?

Output: diabetes remis-sion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Weight loss can result in what for some patients and reduced medication use in most?. ### Response: diabetes remis-sion.


Instruction: How much does multifactorial interventions reduce risk for diabetes among patients with impaired glucose tolerance during 3 to 5 years of treatment?

Output: 43% to 58%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much does multifactorial interventions reduce risk for diabetes among patients with impaired glucose tolerance during 3 to 5 years of treatment?. ### Response: 43% to 58%.


Instruction: What is the benefit achieved in propor-tion to diabetes?

Output: ability to achieve lifestyle goals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the benefit achieved in propor-tion to diabetes?. ### Response: ability to achieve lifestyle goals.


Instruction: What percentage of patients with acute isch-emic stroke will be found to have undiagnosed diabetes after testing with an HbA1c or oral testing?

Output: 20%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients with acute isch-emic stroke will be found to have undiagnosed diabetes after testing with an HbA1c or oral testing?. ### Response: 20%.


Instruction: What is ezetimibe added to statin therapy after acute coronary syndromes?

Output: Grundy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ezetimibe added to statin therapy after acute coronary syndromes?. ### Response: Grundy.


Instruction: What is primary prevention S4.4-1?

Output: coronary artery calcium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is primary prevention S4.4-1?. ### Response: coronary artery calcium.


Instruction: What year did the Engl J Med publish 372:2387–97.4.4?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did the Engl J Med publish 372:2387–97.4.4?. ### Response: 2015.


Instruction: What is the primary prevention S4.4-1?

Output: Ezetimibe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary prevention S4.4-1?. ### Response: Ezetimibe.


Instruction: How long does the association of coronary artery calcium with atherosclerotic cardiovascular disease events last?

Output: Ten-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does the association of coronary artery calcium with atherosclerotic cardiovascular disease events last?. ### Response: Ten-year.


Instruction: Who is responsible for the psychology of clinical decision making?

Output: Avorn J

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is responsible for the psychology of clinical decision making?. ### Response: Avorn J.


Instruction: What is the psychology of clinical decision making—implications for medication use?

Output: Avorn J

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the psychology of clinical decision making—implications for medication use?. ### Response: Avorn J.


Instruction: What did the 2016 ACC expert consensus decision pathway on the role of non-statin therapies for?

Output: LDL-cholesterol lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the 2016 ACC expert consensus decision pathway on the role of non-statin therapies for?. ### Response: LDL-cholesterol lowering.


Instruction: What did the American College of Cardiology Task Force on Clinical Expert Consensus Documents do?

Output: the role of non-statin therapies for LDL-cholesterol lowering in the management of atherosclerotic cardiovascular disease risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the American College of Cardiology Task Force on Clinical Expert Consensus Documents do?. ### Response: the role of non-statin therapies for LDL-cholesterol lowering in the management of atherosclerotic cardiovascular disease risk.


Instruction: What was the focus of the 2017 focused update of the 2016 ACC expert consensus decision pathway?

Output: role of non-statin therapies for LDL-cholesterol lowering in the man-agement of atherosclerotic cardiovascular disease risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the focus of the 2017 focused update of the 2016 ACC expert consensus decision pathway?. ### Response: role of non-statin therapies for LDL-cholesterol lowering in the man-agement of atherosclerotic cardiovascular disease risk.


Instruction: What was the 2016 ACC expert consensus decision pathway on?

Output: the role of non-statin therapies for LDL-cholesterol lowering in the management of atherosclerotic cardiovascular disease risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 2016 ACC expert consensus decision pathway on?. ### Response: the role of non-statin therapies for LDL-cholesterol lowering in the management of atherosclerotic cardiovascular disease risk.


Instruction: What is the role of non-statin therapies for LDL-cholesterol lowering in the man-agement of atherosclerotic cardiovascular disease risk?

Output: management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of non-statin therapies for LDL-cholesterol lowering in the man-agement of atherosclerotic cardiovascular disease risk?. ### Response: management.


Instruction: What is the 2017 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk?

Output: 2016 ACC expert consensus decision pathway

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2017 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk?. ### Response: 2016 ACC expert consensus decision pathway.


Instruction: What did the American College of Cardiology/American Heart Association Task Force on Practice Guidelines do?

Output: reduce cardiovascular risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the American College of Cardiology/American Heart Association Task Force on Practice Guidelines do?. ### Response: reduce cardiovascular risk.


Instruction: What was the 2013 AHA/ACC/TOS guideline for the management of?

Output: overweight and obesity in adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 2013 AHA/ACC/TOS guideline for the management of?. ### Response: overweight and obesity in adults.


Instruction: What was a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society?

Output: AHA/ACC/TOS guideline for the management of overweight and obesity in adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society?. ### Response: AHA/ACC/TOS guideline for the management of overweight and obesity in adults.


Instruction: What was the name of the report?

Output: Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the report?. ### Response: Heart Association Task Force on Practice Guidelines.


Instruction: When was the Circulation. 2014;129:S102-38?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circulation. 2014;129:S102-38?. ### Response: 2014.


Instruction: Where can you find the 2008 Physical Activity Guidelines for Americans?

Output: US Department of Health and Human Services

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find the 2008 Physical Activity Guidelines for Americans?. ### Response: US Department of Health and Human Services.


Instruction: What is the primary prevention of cardiovascular disease with a Mediterranean diet?

Output: S4.4-9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary prevention of cardiovascular disease with a Mediterranean diet?. ### Response: S4.4-9.


Instruction: When was the N Engl J Med 2013 368:1279-90 published?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the N Engl J Med 2013 368:1279-90 published?. ### Response: 2013.


Instruction: What was the name of the 8th ed. 2015-2020 Dietary Guidelines for Americans?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the 8th ed. 2015-2020 Dietary Guidelines for Americans?. ### Response: 2015.


Instruction: What are the 2015 dietary guidelines available at?

Output: http://health.gov/dietary  guidelines/2015/guidelines/.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the 2015 dietary guidelines available at?. ### Response: http://health.gov/dietary  guidelines/2015/guidelines/..


Instruction: What is the name of the document available at http://health.gov/dietary guidelines/2015/guidelines?

Output: Dietary Guidelines for Americans

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the document available at http://health.gov/dietary guidelines/2015/guidelines?. ### Response: Dietary Guidelines for Americans.


Instruction: What is the name of the report on the global tobacco epidemic 2008?

Output: MPOWER package

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the report on the global tobacco epidemic 2008?. ### Response: MPOWER package.


Instruction: When was the MPOWER package released?

Output: July 18, 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the MPOWER package released?. ### Response: July 18, 2013.


Instruction: What are the 21st century hazards of smoking and benefits of cessation in the United States?

Output: McAfee T, Peto R

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the 21st century hazards of smoking and benefits of cessation in the United States?. ### Response: McAfee T, Peto R.


Instruction: What is the doi: 10.1056/NEJMsa1211128?

Output: 290

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the doi: 10.1056/NEJMsa1211128?. ### Response: 290.


Instruction: What is the effect of smoking on short-term outcome of patients undergoing coro-nary artery bypass surgery?

Output: reduces mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of smoking on short-term outcome of patients undergoing coro-nary artery bypass surgery?. ### Response: reduces mortality.


Instruction: What was the title of the 2008 issue of Ann Thorac Surg?

Output: 86:517–523

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the title of the 2008 issue of Ann Thorac Surg?. ### Response: 86:517–523.


Instruction: What is the impact of smoking on the results of coronary artery bypass surgery?

Output: high three-year mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact of smoking on the results of coronary artery bypass surgery?. ### Response: high three-year mortality.


Instruction: What is a population-based study in Iceland?

Output: Deep sternal wound infections following open heart surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a population-based study in Iceland?. ### Response: Deep sternal wound infections following open heart surgery.


Instruction: What year did Cardiovasc J.42:208–213. doi: 10.1080/14017430801919557?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Cardiovasc J.42:208–213. doi: 10.1080/14017430801919557?. ### Response: 2008.


Instruction: What is smoking after coronary artery bypass: high three-year mortality?

Output: Impact of smoking on the results of coronary artery bypass surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is smoking after coronary artery bypass: high three-year mortality?. ### Response: Impact of smoking on the results of coronary artery bypass surgery.


Instruction: What is smoking cessation associated with?

Output: reduced long-term mortality and the need for repeat interventions after coronary artery bypass grafting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is smoking cessation associated with?. ### Response: reduced long-term mortality and the need for repeat interventions after coronary artery bypass grafting.


Instruction: What is the need for repeat interventions after coronary artery bypass grafting?

Output: term mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the need for repeat interventions after coronary artery bypass grafting?. ### Response: term mortality.


Instruction: When did Eur J Cardiovasc Prev Rehabil. 200714:448–450?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Eur J Cardiovasc Prev Rehabil. 200714:448–450?. ### Response: 2007.


Instruction: What does smoking cessation reduce after coronary artery bypass surgery?

Output: mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does smoking cessation reduce after coronary artery bypass surgery?. ### Response: mortality.


Instruction: What is a 20-year follow-up study?

Output: Smoking cessation reduces mortality after coronary artery bypass surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a 20-year follow-up study?. ### Response: Smoking cessation reduces mortality after coronary artery bypass surgery.


Instruction: Harskamp RE, Lopes RD, Baisden CE, de Winter RJ, Alexander JH.

Output: Smoking cessation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Harskamp RE, Lopes RD, Baisden CE, de Winter RJ, Alexander JH.. ### Response: Smoking cessation.


Instruction: What causes saphenous vein graft failure?

Output: smoking

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes saphenous vein graft failure?. ### Response: smoking.


Instruction: What is the effect of smoking status on early and late outcomes after isolated coronary artery bypass?

Output: high three-year mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of smoking status on early and late outcomes after isolated coronary artery bypass?. ### Response: high three-year mortality.


Instruction: What are early and late outcomes after isolated coronary artery bypass graft surgery?

Output: Impact of smoking status

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are early and late outcomes after isolated coronary artery bypass graft surgery?. ### Response: Impact of smoking status.


Instruction: What is the name of the US Public Health Service report on tobacco use and depen-dence?

Output: Tobacco Use and Dependence Clinical Practice Guideline Panel, Staff, and Consortium Representatives

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the US Public Health Service report on tobacco use and depen-dence?. ### Response: Tobacco Use and Dependence Clinical Practice Guideline Panel, Staff, and Consortium Representatives.


Instruction: What is a systematic review of smoking cessation interventions for hospitalized smokers?

Output: Arch Intern Med.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a systematic review of smoking cessation interventions for hospitalized smokers?. ### Response: Arch Intern Med..


Instruction: What are the names of the three groups that made up the guideline panel, staff, and consortium representatives?

Output: Tobacco Use and Dependence Clinical Practice Guideline Panel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the three groups that made up the guideline panel, staff, and consortium representatives?. ### Response: Tobacco Use and Dependence Clinical Practice Guideline Panel.


Instruction: When was JAMA published?

Output: 2000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was JAMA published?. ### Response: 2000.


Instruction: What is a proposed mechanism for the superior QRS axis in ostium primum ASD?

Output: S4.1.4-10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a proposed mechanism for the superior QRS axis in ostium primum ASD?. ### Response: S4.1.4-10.


Instruction: What is the DOI for 2018 ACHD GuidelineCirculation?

Output: 10.1161/CIR.0000000000000603

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the DOI for 2018 ACHD GuidelineCirculation?. ### Response: 10.1161/CIR.0000000000000603.


Instruction: What is the name of the randomized clinical trial of surgical treatment for secun-dum atrial septal defects in patients >40 years old?

Output: J Am Coll Cardiol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized clinical trial of surgical treatment for secun-dum atrial septal defects in patients >40 years old?. ### Response: J Am Coll Cardiol.


Instruction: When was the last year of open heart surgery for congenital heart disease?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last year of open heart surgery for congenital heart disease?. ### Response: 2008.


Instruction: How old are septal defects in patients?

Output: >40 years old

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old are septal defects in patients?. ### Response: >40 years old.


Instruction: What is the name of the randomized clinical trial that evaluated septal defect in patients >40 years old?

Output: S4.1.4-12

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized clinical trial that evaluated septal defect in patients >40 years old?. ### Response: S4.1.4-12.


Instruction: When was the J Am Coll Cardiol.38:2035–42?

Output: 2001

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol.38:2035–42?. ### Response: 2001.


Instruction: How old is the patient?

Output: >40 years old

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old is the patient?. ### Response: >40 years old.


Instruction: How many cases of ventricular septal defect were included in a study?

Output: 790

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many cases of ventricular septal defect were included in a study?. ### Response: 790.


Instruction: What is the name of the defect that was found to be a result of a defect percutaneous closure?

Output: atrial septal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the defect that was found to be a result of a defect percutaneous closure?. ### Response: atrial septal.


Instruction: How many people were involved in the study of the natural history of ventricular septal defects?

Output: 790

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were involved in the study of the natural history of ventricular septal defects?. ### Response: 790.


Instruction: What is ste-nosis in adults?

Output: increased prevalence and slow rate of progression of the obstruction and aortic regurgitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ste-nosis in adults?. ### Response: increased prevalence and slow rate of progression of the obstruction and aortic regurgitation.


Instruction: What is the slow rate of progression of the obstruction and aortic regurgitation?

Output: increased prevalence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the slow rate of progression of the obstruction and aortic regurgitation?. ### Response: increased prevalence.


Instruction: When was the J Am Coll Cardiol.38:835-42?

Output: 2001

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol.38:835-42?. ### Response: 2001.


Instruction: What is a risk factor for aortic valve dysfunction in children with discrete subvalvary dysfunction?

Output: increased prevalence and slow rate of progression of the obstruction and aortic regurgitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for aortic valve dysfunction in children with discrete subvalvary dysfunction?. ### Response: increased prevalence and slow rate of progression of the obstruction and aortic regurgitation.


Instruction: What is the cause of chest pain in a young woman?

Output: membranous sub-aortic stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cause of chest pain in a young woman?. ### Response: membranous sub-aortic stenosis.


Instruction: What causes aortic valve dysfunction in children with discrete subvalvar stenosis?

Output: Risk factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes aortic valve dysfunction in children with discrete subvalvar stenosis?. ### Response: Risk factors.


Instruction: What year did Frontera-Izquierdo P, Cabezuelo-Huerta G study complete atrioventricular septal defect–a 17 year study?

Output: 1990

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Frontera-Izquierdo P, Cabezuelo-Huerta G study complete atrioventricular septal defect–a 17 year study?. ### Response: 1990.


Instruction: What is the name of the surgical management of complete atrioventricular septal defects?

Output: Bando K, Turrentine MW, Sun K, et al.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the surgical management of complete atrioventricular septal defects?. ### Response: Bando K, Turrentine MW, Sun K, et al..


Instruction: How long has the surgeon been in the field of surgical management?

Output: twenty-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long has the surgeon been in the field of surgical management?. ### Response: twenty-year.


Instruction: What is patent ductus arteriosus S4.1.5-1?

Output: Transcatheter closure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is patent ductus arteriosus S4.1.5-1?. ### Response: Transcatheter closure.


Instruction: What is pulmonary arterial hypertension in adults?

Output: severe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is pulmonary arterial hypertension in adults?. ### Response: severe.


Instruction: What is the name of the procedure used to close patent ductus arteriosus?

Output: Percutaneous closure of patent ductus arteriosus in adults using different devices. Rev Esp Cardiol. 2010;63:726–9. S4.1.5-3. Jeong Y-H, Yun T-J, Song J-M, et al. Left ventricular remodeling and change of systolic function after closure of patent ductus arteriosus in adults: device and surgical closure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the procedure used to close patent ductus arteriosus?. ### Response: Percutaneous closure of patent ductus arteriosus in adults using different devices. Rev Esp Cardiol. 2010;63:726–9. S4.1.5-3. Jeong Y-H, Yun T-J, Song J-M, et al. Left ventricular remodeling and change of systolic function after closure of patent ductus arteriosus in adults: device and surgical closure.


Instruction: When was the Rev Esp Cardiol. 63:726–9.

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Rev Esp Cardiol. 63:726–9.. ### Response: 2010.


Instruction: What is left ventricular remodeling and change of systolic function after closure of patent ductus arteriosus in adults?

Output: device and surgical closure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is left ventricular remodeling and change of systolic function after closure of patent ductus arteriosus in adults?. ### Response: device and surgical closure.


Instruction: What is Zabal C, Garca-Montes JA, Buendia-Hernández A, et al. Percutaneous closure of hypertensive ductuitis arterious. 2010;96:625–9.

Output: different devices

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Zabal C, Garca-Montes JA, Buendia-Hernández A, et al. Percutaneous closure of hypertensive ductuitis arterious. 2010;96:625–9.. ### Response: different devices.


Instruction: What is the name of the ductus arteriosus?

Output: Patent Ductus Arteriosus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the ductus arteriosus?. ### Response: Patent Ductus Arteriosus.


Instruction: What are the surgical implications?

Output: increased prevalence and slow rate of progression of the obstruction and aortic regurgitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the surgical implications?. ### Response: increased prevalence and slow rate of progression of the obstruction and aortic regurgitation.


Instruction: What does CIRCHEARTFAILURE stand for?

Output: CIRCHEARTFAILURE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CIRCHEARTFAILURE stand for?. ### Response: CIRCHEARTFAILURE.


Instruction: What does a high-protein diet do to heart failure?

Output: pressure overload

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does a high-protein diet do to heart failure?. ### Response: pressure overload.


Instruction: When did Appl Physiol Nutr Metab. 2014;39:238-247?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Appl Physiol Nutr Metab. 2014;39:238-247?. ### Response: 2014.


Instruction: What is the name of the randomized clinical trial to test the effectiveness of a high protein diet targeting obese individuals with heart failure?

Output: Pro-HEART

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized clinical trial to test the effectiveness of a high protein diet targeting obese individuals with heart failure?. ### Response: Pro-HEART.


Instruction: What are the three main components of failure?

Output: muscle strength, endur-ance, and blood flow

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the three main components of failure?. ### Response: muscle strength, endur-ance, and blood flow.


Instruction: What is the name of the journal that studies exercise training in systolic and diastlic dysfunction?

Output: Am Heart J.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies exercise training in systolic and diastlic dysfunction?. ### Response: Am Heart J..


Instruction: When was the Am Heart J published?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Am Heart J published?. ### Response: 2007.


Instruction: What is the name of the exercise training meta-analysis of trials in patients with chronic heart failure?

Output: ExTraMATCH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the exercise training meta-analysis of trials in patients with chronic heart failure?. ### Response: ExTraMATCH.


Instruction: When did BMJ 328:189?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did BMJ 328:189?. ### Response: 2004.


Instruction: What are the physical responses to different modes of interval exercise in patients with chronic heart failure?

Output: application to exercise training

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the physical responses to different modes of interval exercise in patients with chronic heart failure?. ### Response: application to exercise training.


Instruction: What does Eur Heart J. 1996:17:1040–1047?

Output: Physical responses to different modes of interval exercise in patients with chronic heart failure: application to exercise training

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Eur Heart J. 1996:17:1040–1047?. ### Response: Physical responses to different modes of interval exercise in patients with chronic heart failure: application to exercise training.


Instruction: Exercise and heart failure: a statement from the American Heart Association Committee on Exercise, Rehabilitation, and Prevention. Circulation. 2003;107:1210–1225.

Output: 336

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Exercise and heart failure: a statement from the American Heart Association Committee on Exercise, Rehabilitation, and Prevention. Circulation. 2003;107:1210–1225.. ### Response: 336.


Instruction: What is a statement for healthcare professionals from the American Heart Association?

Output: Exercise standards for testing and train-ing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a statement for healthcare professionals from the American Heart Association?. ### Response: Exercise standards for testing and train-ing.


Instruction: What are exercise standards for testing and train-ing?

Output: a statement for healthcare professionals from the American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are exercise standards for testing and train-ing?. ### Response: a statement for healthcare professionals from the American Heart Association.


Instruction: What increases muscle strength, endurance, and blood flow in patients with chronic heart failure?

Output: Resistance exercise training

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What increases muscle strength, endurance, and blood flow in patients with chronic heart failure?. ### Response: Resistance exercise training.


Instruction: What is the name of the study that found that resistance exercise training increases blood flow and muscle strength?

Output: Am J Cardiol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that found that resistance exercise training increases blood flow and muscle strength?. ### Response: Am J Cardiol.


Instruction: What type of exercise improves functional capacity and strength in CHF?

Output: aerobic and resistance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of exercise improves functional capacity and strength in CHF?. ### Response: aerobic and resistance.


Instruction: What year did Am J Cardiol issue 83:1674–1677, A7?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Am J Cardiol issue 83:1674–1677, A7?. ### Response: 1999.


Instruction: What was the name of the book published in 1985?

Output: J Appl Physiol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the book published in 1985?. ### Response: J Appl Physiol.


Instruction: What year was the book released?

Output: 1985

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the book released?. ### Response: 1985.


Instruction: What is t he rationale and impact section on st ep 1 treatment?

Output: A CE inhibit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is t he rationale and impact section on st ep 1 treatment?. ### Response: A CE inhibit.


Instruction: What is a step 1 treatment?

Output: Step 2 tr eatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a step 1 treatment?. ### Response: Step 2 tr eatment.


Instruction: What is step 2 tr eatment 1.4.40?

Output: step 1 treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is step 2 tr eatment 1.4.40?. ### Response: step 1 treatment.


Instruction: Before considering ne xt step t eatments discuss wit h the person if they are taking what?

Output: t heir medicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Before considering ne xt step t eatments discuss wit h the person if they are taking what?. ### Response: t heir medicine.


Instruction: What is NICE's guideline on medicines adherence?

Output: 1.4.41

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE's guideline on medicines adherence?. ### Response: 1.4.41.


Instruction: What is not contr olled in adult s taking st ep 1 treatment of an ACE?

Output: hyper tension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not contr olled in adult s taking st ep 1 treatment of an ACE?. ### Response: hyper tension.


Instruction: What is a CCB?

Output: thiazide-lik e diur etic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a CCB?. ### Response: thiazide-lik e diur etic.


Instruction: What is an ARB?

Output: inhibit or or • an ARB or • a thiazide-lik e diur etic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an ARB?. ### Response: inhibit or or • an ARB or • a thiazide-lik e diur etic.


Instruction: How is hyper tension treated?

Output: step 1 treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is hyper tension treated?. ### Response: step 1 treatment.


Instruction: What is a step 1 treatment of a CCB?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a step 1 treatment of a CCB?. ### Response: •.


Instruction: What can be used if hyper tension is not controlled?

Output: an ARB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be used if hyper tension is not controlled?. ### Response: an ARB.


Instruction: What does ACE inhibit do?

Output: ARB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ACE inhibit do?. ### Response: ARB.


Instruction: What is a thiazide-lik e diur etic?

Output: an ARB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a thiazide-lik e diur etic?. ### Response: an ARB.


Instruction: What should 2 diabetics consider in addition to step 1 treatment?

Output: an ARB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should 2 diabetics consider in addition to step 1 treatment?. ### Response: an ARB.


Instruction: What is the name of the book that addresses hyper tension in adult s?

Output: NG136

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the book that addresses hyper tension in adult s?. ### Response: NG136.


Instruction: What is the subject of Notice of right s?

Output: Hyper tension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the subject of Notice of right s?. ### Response: Hyper tension.


Instruction: When was the last updat ed?

Output: 18 Mar ch 2022

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last updat ed?. ### Response: 18 Mar ch 2022.


Instruction: When did the search for the current KDIGO Guideline begin?

Output: November 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the search for the current KDIGO Guideline begin?. ### Response: November 2009.


Instruction: Who developed the search strategies?

Output: the ERT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who developed the search strategies?. ### Response: the ERT.


Instruction: Where are the text words or medical subject headings that were included?

Output: Supplementary Appendix 1online

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are the text words or medical subject headings that were included?. ### Response: Supplementary Appendix 1online.


Instruction: Non-human studies and those focusing on dialysis,pregnancy, neonates, malignant hypertension, acute kidneyinjury, or drug pharmacology were excluded from what?

Output: The MEDLINE, Cochrane Central Register of ControlledTrials, and Cochrane Database of Systematic Reviews

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Non-human studies and those focusing on dialysis,pregnancy, neonates, malignant hypertension, acute kidneyinjury, or drug pharmacology were excluded from what?. ### Response: The MEDLINE, Cochrane Central Register of ControlledTrials, and Cochrane Database of Systematic Reviews.


Instruction: What was searched by the ERT to capture all RCTs on the use of BP-lowering agents in CKD?

Output: The MEDLINE, Cochrane Central Register of ControlledTrials, and Cochrane Database of Systematic Reviews

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was searched by the ERT to capture all RCTs on the use of BP-lowering agents in CKD?. ### Response: The MEDLINE, Cochrane Central Register of ControlledTrials, and Cochrane Database of Systematic Reviews.


Instruction: When was the first search conducted for BP-lowering agents in CKD?

Output: November 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the first search conducted for BP-lowering agents in CKD?. ### Response: November 2009.


Instruction: When did the final update of the search take place?

Output: January2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the final update of the search take place?. ### Response: January2011.


Instruction: In what year was the last update done?

Output: January2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was the last update done?. ### Response: January2011.


Instruction: What did TheERT use to identify large, generalpopulation RCTs reporting on subgroup analyses based on CKD, GFR, or proteinuria status?

Output: Work Group members

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did TheERT use to identify large, generalpopulation RCTs reporting on subgroup analyses based on CKD, GFR, or proteinuria status?. ### Response: Work Group members.


Instruction: What was added from the reference lists of JNC 7?

Output: pertinentarticles

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was added from the reference lists of JNC 7?. ### Response: pertinentarticles.


Instruction: How many citations were initially screened?

Output: 10, 657

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many citations were initially screened?. ### Response: 10, 657.


Instruction: What were selected for evidence?

Output: Journalarticles reporting original data, meta-analyses, and systematicreviews

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were selected for evidence?. ### Response: Journalarticles reporting original data, meta-analyses, and systematicreviews.


Instruction: Reporting original data, meta-analyses, and systematic reviews were selected for what purpose?

Output: evidence review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Reporting original data, meta-analyses, and systematic reviews were selected for what purpose?. ### Response: evidence review.


Instruction: Editorials, letters,abstracts, unpublished reports, and articles published in non-peer-reviewed journals were not included in what?

Output: journalsupplements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Editorials, letters,abstracts, unpublished reports, and articles published in non-peer-reviewed journals were not included in what?. ### Response: journalsupplements.


Instruction: The WorkGroup decided to exclude publications from journalsupplements because of differences in how they get solicited, selected, reviewed, and edited?

Output: peer-reviewed publications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The WorkGroup decided to exclude publications from journalsupplements because of differences in how they get solicited, selected, reviewed, and edited?. ### Response: peer-reviewed publications.


Instruction: What type of analyses were also excluded?

Output: Post hoc analyses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of analyses were also excluded?. ### Response: Post hoc analyses.


Instruction: Why were post hoc analyses excluded from RCTs?

Output: BP interventions may take longer time toinﬂuence outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why were post hoc analyses excluded from RCTs?. ### Response: BP interventions may take longer time toinﬂuence outcomes.


Instruction: What could take longer to influence outcomes?

Output: BP interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could take longer to influence outcomes?. ### Response: BP interventions.


Instruction: Interventions may take longer to influence what?

Output: outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Interventions may take longer to influence what?. ### Response: outcomes.


Instruction: Why were these studies downgraded onelevel?

Output: they are of lesser quality than theoriginal RCT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why were these studies downgraded onelevel?. ### Response: they are of lesser quality than theoriginal RCT.


Instruction: What was done by the ERT?

Output: Data extraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was done by the ERT?. ### Response: Data extraction.


Instruction: Who did the data extraction?

Output: the ERT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who did the data extraction?. ### Response: the ERT.


Instruction: What did the ERT design forms to capture?

Output: data on design, methodology, sample characteristics,interventions, comparators, outcomes, results, and limita-tions of individual studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the ERT design forms to capture?. ### Response: data on design, methodology, sample characteristics,interventions, comparators, outcomes, results, and limita-tions of individual studies.


Instruction: How were methods and outcomes systematically graded?

Output: recorded during the data extraction process

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How were methods and outcomes systematically graded?. ### Response: recorded during the data extraction process.


Instruction: What was developed for each comparison ofinterest?

Output: Summary tables

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was developed for each comparison ofinterest?. ### Response: Summary tables.


Instruction: What was included in the evidence base for theKDOQI Clinical Practice Guidelines on Hypertension?

Output: Studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was included in the evidence base for theKDOQI Clinical Practice Guidelines on Hypertension?. ### Response: Studies.


Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al.


Instruction: What is the name of the medical center that is the director of the MD Center?

Output: Corrigan Minehan Heart Center

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the medical center that is the director of the MD Center?. ### Response: Corrigan Minehan Heart Center.


Instruction: Who is the Associate Professor of Medicine at Baylor College of Medicine?

Output: Hani Jneid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Associate Professor of Medicine at Baylor College of Medicine?. ### Response: Hani Jneid.


Instruction: What is Michael DeBakey VA Medical Center Director of?

Output: Interventional Cardiology Research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Michael DeBakey VA Medical Center Director of?. ### Response: Interventional Cardiology Research.


Instruction: What is Eric V. Krieger University of Washington School of Medicine Associate Professor of Medicine?

Output: Director, Seattle Adult Congenital Heart Disease Service

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Eric V. Krieger University of Washington School of Medicine Associate Professor of Medicine?. ### Response: Director, Seattle Adult Congenital Heart Disease Service.


Instruction: Who is Michael Mack Baylor Scott & White Health?

Output: —Chair, Cardiovascular Service line

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Michael Mack Baylor Scott & White Health?. ### Response: —Chair, Cardiovascular Service line.


Instruction: What is Michael Mack Baylor Scott & White Health's job title?

Output: —Chair, Cardiovascular Service line

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Michael Mack Baylor Scott & White Health's job title?. ### Response: —Chair, Cardiovascular Service line.


Instruction: Who is the Chief Medical Officer of the Mayo Clinic?

Output: Christopher McLeod

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Chief Medical Officer of the Mayo Clinic?. ### Response: Christopher McLeod.


Instruction: Where is Christopher McLeod based?

Output: Mayo Clinic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Christopher McLeod based?. ### Response: Mayo Clinic.


Instruction: What is the name of the professor of cardiology at Brigham and Women's Hospital?

Output: Patrick T. O’GaraWatkins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor of cardiology at Brigham and Women's Hospital?. ### Response: Patrick T. O’GaraWatkins.


Instruction: Where is the Distinguished Chair in Cardiology located?

Output: Brigham and Women’s Hospital

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the Distinguished Chair in Cardiology located?. ### Response: Brigham and Women’s Hospital.


Instruction: Who is Professor of Medicine (Cardiology) at Northwestern University?

Output: Vera H. Rigolin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Professor of Medicine (Cardiology) at Northwestern University?. ### Response: Vera H. Rigolin.


Instruction: Who is the Chief of Division of Cardiac Surgery at Massachusetts General Hospital?

Output: Thoralf M. Sundt

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Chief of Division of Cardiac Surgery at Massachusetts General Hospital?. ### Response: Thoralf M. Sundt.


Instruction: Who is the Chief of the Division of Cardiac Surgery atMassachusetts General Hospital?

Output: Thoralf M. Sundt II

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Chief of the Division of Cardiac Surgery atMassachusetts General Hospital?. ### Response: Thoralf M. Sundt II.


Instruction: What is the co-director of Corrigan Minehan Heart Center?

Output: Thoralf M. Sundt

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the co-director of Corrigan Minehan Heart Center?. ### Response: Thoralf M. Sundt.


Instruction: Who is Professor of Anesthesiology, Medicine, and Population Health Sciences at Duke University?

Output: Annemarie Thompson

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Professor of Anesthesiology, Medicine, and Population Health Sciences at Duke University?. ### Response: Annemarie Thompson.


Instruction: Who is Professor of Anesthesiology, Medicine, and Population Health Sciences at the University Medical Center?

Output: Annemarie Thompson

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Professor of Anesthesiology, Medicine, and Population Health Sciences at the University Medical Center?. ### Response: Annemarie Thompson.


Instruction: What is the title of the Director of Anesthesia Residency Program?

Output: Annemarie ThompsonDuke University Medical Center—Professor of Anesthesiology, Medicine, and Population Health Sciences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of the Director of Anesthesia Residency Program?. ### Response: Annemarie ThompsonDuke University Medical Center—Professor of Anesthesiology, Medicine, and Population Health Sciences.


Instruction: Who is the Chief Executive Officer of the Company?

Output: Christopher Toly

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Chief Executive Officer of the Company?. ### Response: Christopher Toly.


Instruction: What was reviewed and updated in conjunction with all meetings and/or conference calls of the Writing Committee during the document development process?

Output: relationships of committee members with industry and other entities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was reviewed and updated in conjunction with all meetings and/or conference calls of the Writing Committee during the document development process?. ### Response: relationships of committee members with industry and other entities.


Instruction: What does not necessarily reflect relationships with industry at the time of writing?

Output: The table

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not necessarily reflect relationships with industry at the time of writing?. ### Response: The table.


Instruction: What percentage of voting stock does a person have a significant interest in?

Output: ≥5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of voting stock does a person have a significant interest in?. ### Response: ≥5%.


Instruction: How much of the fair market value of the business entity does the interest represent?

Output: ≥$5000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the fair market value of the business entity does the interest represent?. ### Response: ≥$5000.


Instruction: What does ownership of 5% of the voting stock or share of a business entity mean?

Output: ≥5% of the voting stock or share of the business entity, or ownership of ≥$5000 of the fair market value of the business entity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ownership of 5% of the voting stock or share of a business entity mean?. ### Response: ≥5% of the voting stock or share of the business entity, or ownership of ≥$5000 of the fair market value of the business entity.


Instruction: How much of the fair market value of a business entity does a person own?

Output: ≥$5000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the fair market value of a business entity does a person own?. ### Response: ≥$5000.


Instruction: What percentage of the person's gross income does the business entity receive from a partnership exceed?

Output: 5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the person's gross income does the business entity receive from a partnership exceed?. ### Response: 5%.


Instruction: What was not found to be safer or more effective in several large trials?

Output: loon angioplasty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not found to be safer or more effective in several large trials?. ### Response: loon angioplasty.


Instruction: When balloon dila-tion is required for in-stent restenosis, cuttingballoons are less likely to slip and may offer a technical advantage over what?

Output: conventional balloons

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When balloon dila-tion is required for in-stent restenosis, cuttingballoons are less likely to slip and may offer a technical advantage over what?. ### Response: conventional balloons.


Instruction: What has been used by some cardiologists as an alternative to cutting balloons?

Output: Scoring balloons

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been used by some cardiologists as an alternative to cutting balloons?. ### Response: Scoring balloons.


Instruction: No RCTs have been reported about what?

Output: Scoring balloons

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No RCTs have been reported about what?. ### Response: Scoring balloons.


Instruction: What should be used during SVG PCI?

Output: Embolic protection devices

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be used during SVG PCI?. ### Response: Embolic protection devices.


Instruction: When should EPDs be used?

Output: during saphenous vein graft (SVG) PCI when tech-nically feasible

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When should EPDs be used?. ### Response: during saphenous vein graft (SVG) PCI when tech-nically feasible.


Instruction: How much did distal balloon occlusion EPD decrease the 30-day composite outcome of death, MI, emergency CABG, or target-lesion revascularization in the only RCT?

Output: 9.6% versus16.5%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much did distal balloon occlusion EPD decrease the 30-day composite outcome of death, MI, emergency CABG, or target-lesion revascularization in the only RCT?. ### Response: 9.6% versus16.5%).


Instruction: What has demonstrated similar benefit with proximalocclusion and distal filter EPDs?

Output: noninferiority com-parisons

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has demonstrated similar benefit with proximalocclusion and distal filter EPDs?. ### Response: noninferiority com-parisons.


Instruction: What do distalEPDs not improve in patientsundergoing native-artery PCI?

Output: survival or reinfarction rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do distalEPDs not improve in patientsundergoing native-artery PCI?. ### Response: survival or reinfarction rates.


Instruction: What is a recommendation class IIb1?

Output: Percutaneous Hemodynamic SupportDevices

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a recommendation class IIb1?. ### Response: Percutaneous Hemodynamic SupportDevices.


Instruction: What is often used as an adjunct to PCIin hemodynamically unstable patients?

Output: IABP counterpulsation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is often used as an adjunct to PCIin hemodynamically unstable patients?. ### Response: IABP counterpulsation.


Instruction: What was associated with lower mortality and fewer major complications compared with rescue use of IABP?

Output: routine prophylactic use of IABP during PCI inhigh-risk patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with lower mortality and fewer major complications compared with rescue use of IABP?. ### Response: routine prophylactic use of IABP during PCI inhigh-risk patients.


Instruction: What is the only RCT in high-risk PCI patients?

Output: BCIS-1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the only RCT in high-risk PCI patients?. ### Response: BCIS-1.


Instruction: What was the primary composite outcome of the RCT?

Output: routine and provisional use of IABP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary composite outcome of the RCT?. ### Response: routine and provisional use of IABP.


Instruction: What was the “bailout” rate of IABP insertion in the provisionalIABP group?

Output: 12%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the “bailout” rate of IABP insertion in the provisionalIABP group?. ### Response: 12%,.


Instruction: What were the major secondary endpoints except procedural complications lower in?

Output: routine IABP group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the major secondary endpoints except procedural complications lower in?. ### Response: routine IABP group.


Instruction: Bleding andaccess site complication rates were higher in what?

Output: theroutine IABP group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Bleding andaccess site complication rates were higher in what?. ### Response: theroutine IABP group.


Instruction: What was the provisional IABP group for proceduralhypotension?

Output: 12%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the provisional IABP group for proceduralhypotension?. ### Response: 12%,.


Instruction: What did not show improved outcomes with the use ofIABP?

Output: IABP therapy in patientswith STEMI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did not show improved outcomes with the use ofIABP?. ### Response: IABP therapy in patientswith STEMI.


Instruction: The Impella Recover LP 2.5 System is a what?

Output: 12.5 Fr catheter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The Impella Recover LP 2.5 System is a what?. ### Response: 12.5 Fr catheter.


Instruction: How many Fr femoral artery sheathand is placed across the aortic valve into the left ventricle?

Output: 13

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many Fr femoral artery sheathand is placed across the aortic valve into the left ventricle?. ### Response: 13.


Instruction: What provides flows of upto 2.5 L/min through the Impella 2.5?

Output: a transaxial blood pump

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What provides flows of upto 2.5 L/min through the Impella 2.5?. ### Response: a transaxial blood pump.


Instruction: What has been studied in high-risk PCI?

Output: The hemodynamiceffects of the Impella 2.5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been studied in high-risk PCI?. ### Response: The hemodynamiceffects of the Impella 2.5.


Instruction: What is the Impella 2.5?

Output: Recover LP 2.5 System

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Impella 2.5?. ### Response: Recover LP 2.5 System.


Instruction: What is NICE 2018's approach to care for?

Output: Chronic Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE 2018's approach to care for?. ### Response: Chronic Heart Failure.


Instruction: What is the ISBN number of the book?

Output: 978 -1-4731 -3093 -7 310

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ISBN number of the book?. ### Response: 978 -1-4731 -3093 -7 310.


Instruction: What type of studies compare MDTs with 'usual care'?

Output: Comparators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of studies compare MDTs with 'usual care'?. ### Response: Comparators.


Instruction: What must be a clear description of for a study to be included?

Output: collaborative working between more than one hea lthcare profession or discipline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must be a clear description of for a study to be included?. ### Response: collaborative working between more than one hea lthcare profession or discipline.


Instruction: What must have included the delivery of at least two face-to-face meetings?

Output: The intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must have included the delivery of at least two face-to-face meetings?. ### Response: The intervention.


Instruction: What may be included in a study involving an intervention delivered by one specified health profession?

Output: multidisciplinary collaboration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be included in a study involving an intervention delivered by one specified health profession?. ### Response: multidisciplinary collaboration.


Instruction: What was the length of intervention delivered in the study?

Output: ≤ three months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the length of intervention delivered in the study?. ### Response: ≤ three months.


Instruction: What was used where study length varied due to recruitment dates?

Output: average length

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was used where study length varied due to recruitment dates?. ### Response: average length.


Instruction: What was used when recruitment dates, average length was used?

Output: study length

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was used when recruitment dates, average length was used?. ### Response: study length.


Instruction: When study length varied due to the needs of the patient, what was the shortest duration of protocol?

Output: average length

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When study length varied due to the needs of the patient, what was the shortest duration of protocol?. ### Response: average length.


Instruction: What were the Outcomes CRITICAL?

Output: All-cause mortality (Time to event)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the Outcomes CRITICAL?. ### Response: All-cause mortality (Time to event).


Instruction: What is an example of an unplanned hospitalization?

Output: Count rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of an unplanned hospitalization?. ### Response: Count rate.


Instruction: What is a common adverse event for palliative care patients?

Output: hypotension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a common adverse event for palliative care patients?. ### Response: hypotension.


Instruction: What are the remit of the acute heart failure guidelines?

Output: Studies that were concerned with the care and discharge management of patients hospitalised for decompensation of heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the remit of the acute heart failure guidelines?. ### Response: Studies that were concerned with the care and discharge management of patients hospitalised for decompensation of heart failure.


Instruction: What are RCTs (including cluster randomised)?

Output: Systematic Review of RCTs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are RCTs (including cluster randomised)?. ### Response: Systematic Review of RCTs.


Instruction: What is the remit of the acute heart failure guidelines?

Output: Studies that were concerned with the care and discharge management of patients hospitalised for decompensation of heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the remit of the acute heart failure guidelines?. ### Response: Studies that were concerned with the care and discharge management of patients hospitalised for decompensation of heart failure.


Instruction: How many face-to-face meetings were required after the patient had been discharged?

Output: at least one

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many face-to-face meetings were required after the patient had been discharged?. ### Response: at least one.


Instruction: What is no minimum duration of intervention?

Output: at least three months  after the interven tion begins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is no minimum duration of intervention?. ### Response: at least three months  after the interven tion begins.


Instruction: There is no minimum duration of what?

Output: intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is no minimum duration of what?. ### Response: intervention.


Instruction: The last outcome measure must be at least how many months after the intervention begins?

Output: three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The last outcome measure must be at least how many months after the intervention begins?. ### Response: three.


Instruction: Studies that were concerned with interventions covered elsewhere in the guideline were excluded because they will have separate guidance.

Output: acute heart failure guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Studies that were concerned with interventions covered elsewhere in the guideline were excluded because they will have separate guidance.. ### Response: acute heart failure guidelines.


Instruction: What was considered likely to differ significantly from the UK / NHS standard if the study was carri ed out in a country outside of the OECD or in the United States?

Output: Usual care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was considered likely to differ significantly from the UK / NHS standard if the study was carri ed out in a country outside of the OECD or in the United States?. ### Response: Usual care.


Instruction: How many studies were included in the review?

Output: Twenty two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were included in the review?. ### Response: Twenty two.


Instruction: What type of trial was compared with “usual care” without an MDT?

Output: randomised trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of trial was compared with “usual care” without an MDT?. ### Response: randomised trials.


Instruction: How many main ‘stran ds’ were there?

Output: 4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many main ‘stran ds’ were there?. ### Response: 4.


Instruction: How many interventions were heterogeneous?

Output: 4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many interventions were heterogeneous?. ### Response: 4.


Instruction: What was the Cochrane report 326?

Output: Interventions were heterogeneous, and were categorised into 4 main ‘stran ds’ based on the definitions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the Cochrane report 326?. ### Response: Interventions were heterogeneous, and were categorised into 4 main ‘stran ds’ based on the definitions.


Instruction: What was the name of the trial that compared losartan with captopril 150 mg/d?

Output: The Evaluation of Losartan in the Elderly (ELITE) II trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the trial that compared losartan with captopril 150 mg/d?. ### Response: The Evaluation of Losartan in the Elderly (ELITE) II trial.


Instruction: What were the rates of all-cause mortality and sudden death or resuscitation of arrests for the Losartan group?

Output: not significantly different

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the rates of all-cause mortality and sudden death or resuscitation of arrests for the Losartan group?. ### Response: not significantly different.


Instruction: What was not significantly different from those for the captopril group?

Output: rates of all-cause mortality and sudden death or resuscitated arrests

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not significantly different from those for the captopril group?. ### Response: rates of all-cause mortality and sudden death or resuscitated arrests.


Instruction: What did the Valsartan Heart Failure Trial assess the efficacy of at doses up to 320 mg/d added to standard therapy for?

Output: reducing morbidity and mortality in patients with HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Valsartan Heart Failure Trial assess the efficacy of at doses up to 320 mg/d added to standard therapy for?. ### Response: reducing morbidity and mortality in patients with HF.


Instruction: How much reduction in the combined doses of val-artan showed by patients receiving the drug?

Output: 13.2%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much reduction in the combined doses of val-artan showed by patients receiving the drug?. ### Response: 13.2%.


Instruction: What did patients receiving val-sartan demonstrate a 13.2% reduction in?

Output: the combined end point of cardiovascular mortality and morbidity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did patients receiving val-sartan demonstrate a 13.2% reduction in?. ### Response: the combined end point of cardiovascular mortality and morbidity.


Instruction: What program provides additional insights into the value of ARBs?

Output: Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What program provides additional insights into the value of ARBs?. ### Response: Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM).


Instruction: What is CHARM?

Output: CHARM-Added trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CHARM?. ### Response: CHARM-Added trial.


Instruction: What was associated with a significant reduction in the primary composite end point of cardiovascular death and hospital read-mission for HF compared with placebo?

Output: candesartan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with a significant reduction in the primary composite end point of cardiovascular death and hospital read-mission for HF compared with placebo?. ### Response: candesartan.


Instruction: What did valsartan and captopril show in the combination arm of V ALIANT?

Output: no increased effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did valsartan and captopril show in the combination arm of V ALIANT?. ### Response: no increased effect.


Instruction: What was the result of the CHARM-Added trial?

Output: patients with stable LV dysfunction benefited from the combination of an ACE inhibitor and the ARB candesartan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the result of the CHARM-Added trial?. ### Response: patients with stable LV dysfunction benefited from the combination of an ACE inhibitor and the ARB candesartan.


Instruction: Patients with stable LV dysfunction benefited from what?

Output: combination of an ACE inhibitor and the ARB candesartan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with stable LV dysfunction benefited from what?. ### Response: combination of an ACE inhibitor and the ARB candesartan.


Instruction: How did patients with stable LV dysfunction benefit from the combination of an ACE inhibitor and the ARB candesartan?

Output: significant reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did patients with stable LV dysfunction benefit from the combination of an ACE inhibitor and the ARB candesartan?. ### Response: significant reduction.


Instruction: The lack of superiority of the combination treatment in the V ALIANT trial was likely attributable to the fact that what was titrated aggressively at the time?

Output: ACE inhibitors and ARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The lack of superiority of the combination treatment in the V ALIANT trial was likely attributable to the fact that what was titrated aggressively at the time?. ### Response: ACE inhibitors and ARBs.


Instruction: When were ACE inhibitors and ARBs titrated aggressively at the same time?

Output: early post-MI period

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When were ACE inhibitors and ARBs titrated aggressively at the same time?. ### Response: early post-MI period.


Instruction: What resulted in more side effects?

Output: ACE inhibitors and ARBs were titrated aggressively at the same time in the early post-MI period

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What resulted in more side effects?. ### Response: ACE inhibitors and ARBs were titrated aggressively at the same time in the early post-MI period.


Instruction: In stable HF patients undergoing an established ace inhibitor therapy, what was well tolerated and beneficial?

Output: the addition of an ARB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In stable HF patients undergoing an established ace inhibitor therapy, what was well tolerated and beneficial?. ### Response: the addition of an ARB.


Instruction: What is a strategy that could be used to control BP if needed?

Output: addition of an ARB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a strategy that could be used to control BP if needed?. ### Response: addition of an ARB.


Instruction: What lowers BP and is negatively inotropic and chro-notropic?

Output: β-Blockersβ-Blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What lowers BP and is negatively inotropic and chro-notropic?. ### Response: β-Blockersβ-Blockers.


Instruction: What is the role of -blockers in the management of patients with HF?

Output: ACE inhib-itors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of -blockers in the management of patients with HF?. ### Response: ACE inhib-itors.


Instruction: What was the name of the trial that randomized patients with NYHA class II to IV HF symptoms to receive metoprolol succinate ver -sus?

Output: Metoprolol CR/XL Randomized Intervention Trial in Heart Failure (MERIT-HF)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the trial that randomized patients with NYHA class II to IV HF symptoms to receive metoprolol succinate ver -sus?. ### Response: Metoprolol CR/XL Randomized Intervention Trial in Heart Failure (MERIT-HF).


Instruction: Why was the trial stopped prematurely?

Output: 34% reduction in mortality in the metoprolol arm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the trial stopped prematurely?. ### Response: 34% reduction in mortality in the metoprolol arm.


Instruction: Why was this trial stopped prematurely?

Output: 34% reduction in mortality in the metoprolol arm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was this trial stopped prematurely?. ### Response: 34% reduction in mortality in the metoprolol arm.


Instruction: What was the reduction in mortality in the metoprolol arm?

Output: 34%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the reduction in mortality in the metoprolol arm?. ### Response: 34%.


Instruction: How many clinical trials of carvedilol in HF were stopped premature?

Output: Four

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many clinical trials of carvedilol in HF were stopped premature?. ### Response: Four.


Instruction: What did the COPERNICUS trial assess?

Output: patients with severe HF symp-toms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the COPERNICUS trial assess?. ### Response: patients with severe HF symp-toms.


Instruction: What was the LV ejection fraction 25%?

Output: <25%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the LV ejection fraction 25%?. ### Response: <25%..


Instruction: What is the percentage change in LMWH dose in response to an out-of-range anti-factor Xa concentrationoptimal to return the concentration to the therapeutic range?

Output: optimal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the percentage change in LMWH dose in response to an out-of-range anti-factor Xa concentrationoptimal to return the concentration to the therapeutic range?. ### Response: optimal.


Instruction: What is the comparative effectiveness of adjusting LMWHdoses based on the results of anti-factor Xa concentrations?

Output: What is the comparative effectiveness of adjusting LMWHdoses based on the results of anti –factor Xa concentrations(performed in a manner that ensures accuracy and reproduc-ibility) vs no such monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the comparative effectiveness of adjusting LMWHdoses based on the results of anti-factor Xa concentrations?. ### Response: What is the comparative effectiveness of adjusting LMWHdoses based on the results of anti –factor Xa concentrations(performed in a manner that ensures accuracy and reproduc-ibility) vs no such monitoring.


Instruction: What is done in a manner that ensures accuracy and reproduc-ibility?

Output: adjusting LMWHdoses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is done in a manner that ensures accuracy and reproduc-ibility?. ### Response: adjusting LMWHdoses.


Instruction: What type of therapy is being used for the treatment of VTE?

Output: DOAC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is being used for the treatment of VTE?. ### Response: DOAC.


Instruction: What is the DOAC anticoagulant effect vs no3270 WITT et al 27 NOVEMBER 2018 xVOLUME 2, NUMBER 22Downloaded from http://ashpublications.org/bloodadvances/article-pdf/2/22/3257/1630010/advantces024893cg?

Output: treatment ofVTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the DOAC anticoagulant effect vs no3270 WITT et al 27 NOVEMBER 2018 xVOLUME 2, NUMBER 22Downloaded from http://ashpublications.org/bloodadvances/article-pdf/2/22/3257/1630010/advantces024893cg?. ### Response: treatment ofVTE.


Instruction: What does RWI stand for?

Output: RWI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does RWI stand for?. ### Response: RWI.


Instruction: Who maintains adatabase that tracks all relevant relationships?

Output: The ACC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who maintains adatabase that tracks all relevant relationships?. ### Response: The ACC.