Instruction: How many people were enrolled in the Treatment of Mild Hypertension Study?

Output: 219–27. S10.2.1-4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were enrolled in the Treatment of Mild Hypertension Study?. ### Response: 219–27. S10.2.1-4.


Instruction: What is the name of the group that studies the anti-hypertensive effects of amlodipine?

Output: The Amlodipine Cardiovascular Community Trial Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that studies the anti-hypertensive effects of amlodipine?. ### Response: The Amlodipine Cardiovascular Community Trial Study Group.


Instruction: What are the names of the groups that study the antihypertension effects of the drug?

Output: The Amlodipine Cardiovascular Community Trial Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the groups that study the antihypertension effects of the drug?. ### Response: The Amlodipine Cardiovascular Community Trial Study Group.


Instruction: In what year did the J Clin Hypertens publish a chapter on the topic of hypertension in women?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did the J Clin Hypertens publish a chapter on the topic of hypertension in women?. ### Response: 2008.


Instruction: Where is I. J Clin Hypertens located?

Output: Greenwich

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is I. J Clin Hypertens located?. ### Response: Greenwich.


Instruction: Where is Pregnancy S10.2.2-1?

Output: J Clin Hypertens (Greenwich). 2008;10:406–10.10.2.2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Pregnancy S10.2.2-1?. ### Response: J Clin Hypertens (Greenwich). 2008;10:406–10.10.2.2.


Instruction: What is the name of James PR, Nelson-Piercy C?

Output: Management of hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of James PR, Nelson-Piercy C?. ### Response: Management of hypertension.


Instruction: What is a documented time point after stroke for targeted intervention delivery?

Output: basis for intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a documented time point after stroke for targeted intervention delivery?. ### Response: basis for intervention.


Instruction: A detailed intervention description that identifies the frequency and duration of the intervention, the personnel required to deliver the intervention and the intervention setting?

Output: skill level and training in behavioral counseling of the interventionist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A detailed intervention description that identifies the frequency and duration of the intervention, the personnel required to deliver the intervention and the intervention setting?. ### Response: skill level and training in behavioral counseling of the interventionist.


Instruction: What type of data collection permits disaggregation by sex and other relevant characteristics to identify responders/nonresponders to intervention?

Output: Data collection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of data collection permits disaggregation by sex and other relevant characteristics to identify responders/nonresponders to intervention?. ### Response: Data collection.


Instruction: How are health equityrecommendations summarized in online Data Supplement 65?

Output: Referenced studies that support recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are health equityrecommendations summarized in online Data Supplement 65?. ### Response: Referenced studies that support recommendations.


Instruction: What is one of the social determinants of health in stroke patients?

Output: literacy level

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the social determinants of health in stroke patients?. ### Response: literacy level.


Instruction: What is a social determinant of health?

Output: literacy level, language proficiency, medica-tion affordability, food insecurity, housing, and transportation barriers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a social determinant of health?. ### Response: literacy level, language proficiency, medica-tion affordability, food insecurity, housing, and transportation barriers.


Instruction: How is managing stroke risk factors recommended?

Output: to reduce healthcare disparities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is managing stroke risk factors recommended?. ### Response: to reduce healthcare disparities.


Instruction: In patients with stroke or TIA, what is recommended to reduce healthcare disparities?

Output: evaluating and addressing social determinants of health

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with stroke or TIA, what is recommended to reduce healthcare disparities?. ### Response: evaluating and addressing social determinants of health.


Instruction: What is recommended to reduce healthcare disparities?

Output: evaluating and addressing social determinants of health

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended to reduce healthcare disparities?. ### Response: evaluating and addressing social determinants of health.


Instruction: In patients with stroke or TIA, what is monitored to allow inequities to be identified and addressed?

Output: achievement of nationally accepted, evidence-based performance measures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with stroke or TIA, what is monitored to allow inequities to be identified and addressed?. ### Response: achievement of nationally accepted, evidence-based performance measures.


Instruction: What does monitoring the achievement of nationally accepted, evidence-based performance measures allow?

Output: inequities to be identified and addressed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does monitoring the achievement of nationally accepted, evidence-based performance measures allow?. ### Response: inequities to be identified and addressed.


Instruction: What is recommended to integrate health literacy into the secondary prevention of stroke?

Output: systematic adoption of the Agency for Healthcare Research and Quality Universal Precautions Toolkit for Health Literacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended to integrate health literacy into the secondary prevention of stroke?. ### Response: systematic adoption of the Agency for Healthcare Research and Quality Universal Precautions Toolkit for Health Literacy.


Instruction: What is the optimal intervention model for patients from urban, predominantly minority, or low-socioeconomic-status groups?

Output: unknown

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the optimal intervention model for patients from urban, predominantly minority, or low-socioeconomic-status groups?. ### Response: unknown.


Instruction: What is the optimal intervention model for improving stroke risk factor control and reducing disparities?

Output: unknown

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the optimal intervention model for improving stroke risk factor control and reducing disparities?. ### Response: unknown.


Instruction: What is structural racism defined as?

Output: the normal-ization and legitimization of an array of dynamics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is structural racism defined as?. ### Response: the normal-ization and legitimization of an array of dynamics.


Instruction: What causes and perpetuates structural racism?

Output: inequities in recurrent stroke risk and vascular risk factor control after stroke. Many of these inequities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes and perpetuates structural racism?. ### Response: inequities in recurrent stroke risk and vascular risk factor control after stroke. Many of these inequities.


Instruction: How many non-white populations have higher recurrent stroke risk?

Output: 860,861

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many non-white populations have higher recurrent stroke risk?. ### Response: 860,861.


Instruction: Who are less likely to receive guideline-recommended stroke prevention interventions?

Output: Non-White populations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who are less likely to receive guideline-recommended stroke prevention interventions?. ### Response: Non-White populations.


Instruction: What are other populations at risk for inequities in risk factor control after stroke?

Output: women, rural dwellers, the elderly, immigrants, individuals with low socioeconomic status

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are other populations at risk for inequities in risk factor control after stroke?. ### Response: women, rural dwellers, the elderly, immigrants, individuals with low socioeconomic status.


Instruction: Who are women, rural dwellers, elderly, immigrants, and lesbian, gay?

Output: individuals with low socioeconomic status

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who are women, rural dwellers, elderly, immigrants, and lesbian, gay?. ### Response: individuals with low socioeconomic status.


Instruction: What are some of the groups that have low socioeconomic status?

Output: urban, predominantly minority

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the groups that have low socioeconomic status?. ### Response: urban, predominantly minority.


Instruction: When was the standardized version of ahajournals released?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the standardized version of ahajournals released?. ### Response: April 28, 2023.


Instruction: What is the VA/SCD GuidelineCirculation. 2018;138:e272–e391. DOI: 10.1161/CIR.0000000000000549 September 25, 2018 e287CLINICAL STATEMENTS AND GUIDELINES4.2.2.

Output: Al-Khatib et al 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/SCD GuidelineCirculation. 2018;138:e272–e391. DOI: 10.1161/CIR.0000000000000549 September 25, 2018 e287CLINICAL STATEMENTS AND GUIDELINES4.2.2.. ### Response: Al-Khatib et al 2017.


Instruction: What is useful to evaluate if symptoms are caused by VA?

Output: Ambulatory electrocardiographic monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is useful to evaluate if symptoms are caused by VA?. ### Response: Ambulatory electrocardiographic monitoring.


Instruction: What is often used to assess the effectiveness of treatments to sup-press arrhythmias?

Output: Ambulatory electrocardiographic monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is often used to assess the effectiveness of treatments to sup-press arrhythmias?. ### Response: Ambulatory electrocardiographic monitoring.


Instruction: What type of recording is helpful in diagnosing suspected arrhythmias?

Output: ambulatory ECG monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of recording is helpful in diagnosing suspected arrhythmias?. ### Response: ambulatory ECG monitoring.


Instruction: What is the yield of electrocardiographic tests?

Output: relatively low

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the yield of electrocardiographic tests?. ### Response: relatively low.


Instruction: What is the yield of these tests?

Output: relatively low

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the yield of these tests?. ### Response: relatively low.


Instruction: What is occasionally documented?

Output: ambulatory electrocardiographic recording

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is occasionally documented?. ### Response: ambulatory electrocardiographic recording.


Instruction: A 24-hour continuous Holter recording is appropriate when symptoms occur at least once a day or when quantitation of what is desired?

Output: PVCs/NSVT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A 24-hour continuous Holter recording is appropriate when symptoms occur at least once a day or when quantitation of what is desired?. ### Response: PVCs/NSVT.


Instruction: What are more appropriate for sporadic symptoms?

Output: event or “looping” monitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are more appropriate for sporadic symptoms?. ### Response: event or “looping” monitors.


Instruction: What can be activated over extended periods of time and increase diagnostic yield?

Output: event or “looping” monitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be activated over extended periods of time and increase diagnostic yield?. ### Response: event or “looping” monitors.


Instruction: Adhesive patch electrocardiographic monitors can record for how long?

Output: weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Adhesive patch electrocardiographic monitors can record for how long?. ### Response: weeks.


Instruction: What does 1-lead monitoring and patient activation for symptoms do?

Output: continuous short-term

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does 1-lead monitoring and patient activation for symptoms do?. ### Response: continuous short-term.


Instruction: Studies have shown satisfactory patient compli-ance and what else?

Output: arrhythmia detection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Studies have shown satisfactory patient compli-ance and what else?. ### Response: arrhythmia detection.


Instruction: What is not dis-covered until the patch is returned for analysis?

Output: detected arrhythmias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not dis-covered until the patch is returned for analysis?. ### Response: detected arrhythmias.


Instruction: Serial evaluations with exercise testing and 24-hour ambulatory monitoring are also used to assess what?

Output: rhythm burden and response of VA to therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Serial evaluations with exercise testing and 24-hour ambulatory monitoring are also used to assess what?. ### Response: rhythm burden and response of VA to therapy.


Instruction: What are also used to assess rhythm burden and response of VA to therapy?

Output: Serial evaluations with exercise  testing and/or 24-hour ambulatory monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are also used to assess rhythm burden and response of VA to therapy?. ### Response: Serial evaluations with exercise  testing and/or 24-hour ambulatory monitoring.


Instruction: What are implantable monitors covered in Section 4.2.3?

Output: continu-ous rhythm monitoring and stored recordings of electrograms based on patient activation or pre-set parameters

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are implantable monitors covered in Section 4.2.3?. ### Response: continu-ous rhythm monitoring and stored recordings of electrograms based on patient activation or pre-set parameters.


Instruction: When the suspicion of VA in a patient is high, outpatient ambulatory monitoring is inappropriate as what?

Output: prompt diagnosis and prevention of VA are warranted

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When the suspicion of VA in a patient is high, outpatient ambulatory monitoring is inappropriate as what?. ### Response: prompt diagnosis and prevention of VA are warranted.


Instruction: What is warranted to prevent VA?

Output: outpatient ambulatory monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is warranted to prevent VA?. ### Response: outpatient ambulatory monitoring.


Instruction: What is important to accurately cor -relate the symptoms with?

Output: the arrhythmias detected by ambulatory ECG monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is important to accurately cor -relate the symptoms with?. ### Response: the arrhythmias detected by ambulatory ECG monitoring.


Instruction: Data Supplement 5.COR LOE RecommendationIIa B-R1 What can be useful in patients with sporadic symptoms suspected to be related to VA?

Output: implanted cardiac monitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Data Supplement 5.COR LOE RecommendationIIa B-R1 What can be useful in patients with sporadic symptoms suspected to be related to VA?. ### Response: implanted cardiac monitors.


Instruction: What can implanted cardiac monitors provide?

Output: continu-ous rhythm monitoring and stored recordings of electrograms based on patient activation or pre-set parameters

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can implanted cardiac monitors provide?. ### Response: continu-ous rhythm monitoring and stored recordings of electrograms based on patient activation or pre-set parameters.


Instruction: based on patient activation or pre-set parameters, allowing a prolonged monitor?

Output: Implanted cardiac monitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: based on patient activation or pre-set parameters, allowing a prolonged monitor?. ### Response: Implanted cardiac monitors.


Instruction: How many strokes were there in July 2021?

Output: e460

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes were there in July 2021?. ### Response: e460.


Instruction: What is the name of the guideline for secondary prevention of ischemic strokethrombophilia in neonates and children?

Output: Guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the guideline for secondary prevention of ischemic strokethrombophilia in neonates and children?. ### Response: Guideline.


Instruction: When was Circulation. 2010?

Output: 121:1838–1847

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Circulation. 2010?. ### Response: 121:1838–1847.


Instruction: What is the name of the systematic review and meta-analysis of observational studies?

Output: Guideline for the Secondary Prevention of Ischemic Strokethrombophilia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta-analysis of observational studies?. ### Response: Guideline for the Secondary Prevention of Ischemic Strokethrombophilia.


Instruction: What does Circulation. 2010 say about the risk of cerebral ischaemia?

Output: 121:1838–1847

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Circulation. 2010 say about the risk of cerebral ischaemia?. ### Response: 121:1838–1847.


Instruction: What type of ischaemia is found in patent foramen ovale patients?

Output: cerebral

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of ischaemia is found in patent foramen ovale patients?. ### Response: cerebral.


Instruction: What is the name of the systematic review and meta-analysis of the literature?

Output: Guideline for the Secondary Prevention of Ischemic Strokethrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta-analysis of observational studies. Circulation. 2010;121:1838–1847 . doi: 10.1161/CIRCULATIONAHA.109.913673 603. Pezzini A, Grassi M, Zotto ED, Giossi A, Volonghi I, Costa P, Grau A, Magoni M, Padovani A, Lichy C. Do common prothrombotic mutations influence the risk of cerebral ischaemia in patients with patent foramen ovale? Systematic review and meta-analysis. Thromb Haemost

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta-analysis of the literature?. ### Response: Guideline for the Secondary Prevention of Ischemic Strokethrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta-analysis of observational studies. Circulation. 2010;121:1838–1847 . doi: 10.1161/CIRCULATIONAHA.109.913673 603. Pezzini A, Grassi M, Zotto ED, Giossi A, Volonghi I, Costa P, Grau A, Magoni M, Padovani A, Lichy C. Do common prothrombotic mutations influence the risk of cerebral ischaemia in patients with patent foramen ovale? Systematic review and meta-analysis. Thromb Haemost.


Instruction: Which factors do not increase the risk of stroke?

Output: Prothrombotic factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which factors do not increase the risk of stroke?. ### Response: Prothrombotic factors.


Instruction: What does not increase the risk of recurrent ischemic events after cryptogenic stroke at young age?

Output: Prothrombotic factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not increase the risk of recurrent ischemic events after cryptogenic stroke at young age?. ### Response: Prothrombotic factors.


Instruction: What is the name of the study that found that prothrombotic factors do not cause recurrence of ischemia?

Output: FUTURE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that found that prothrombotic factors do not cause recurrence of ischemia?. ### Response: FUTURE.


Instruction: When was the J Thromb Thrombolysis published?

Output: 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Thromb Thrombolysis published?. ### Response: 2018.


Instruction: What is the name of the systematic review and meta-analysis of inherited thrombophilia and the risk of arterial ischemic stroke?

Output: Guideline for the Secondary Prevention of Ischemic Strokethrombophilia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta-analysis of inherited thrombophilia and the risk of arterial ischemic stroke?. ### Response: Guideline for the Secondary Prevention of Ischemic Strokethrombophilia.


Instruction: What does JAHA.119.012877 do?

Output: 10.1161/JAHA.119.012877 606

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does JAHA.119.012877 do?. ### Response: 10.1161/JAHA.119.012877 606.


Instruction: What is a joint consensus document from the European Society of Cardiology working groups of aorta and peripheral vascular diseases and pulmonary circulation and right ventricular function?

Output: Diagnosis and man-agement of acute deep vein thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a joint consensus document from the European Society of Cardiology working groups of aorta and peripheral vascular diseases and pulmonary circulation and right ventricular function?. ### Response: Diagnosis and man-agement of acute deep vein thrombosis.


Instruction: What is pulmonary circulation and right ventricular function?

Output: aorta and peripheral vascular diseases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is pulmonary circulation and right ventricular function?. ### Response: aorta and peripheral vascular diseases.


Instruction: What is the name of the prospective study of markers of hemostatic func-tion with risk of ischemic stroke?

Output: Guideline for the Secondary Prevention of Ischemic Strokethrombophilia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective study of markers of hemostatic func-tion with risk of ischemic stroke?. ### Response: Guideline for the Secondary Prevention of Ischemic Strokethrombophilia.


Instruction: What is the Atherosclerosis Risk in Communities (ARIC) Study Investigators?

Output: Prospective study of markers of hemostatic func-tion with risk of ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Atherosclerosis Risk in Communities (ARIC) Study Investigators?. ### Response: Prospective study of markers of hemostatic func-tion with risk of ischemic stroke.


Instruction: When was the Circulation.100:736–742. doi: 10.1161/01.cir.100.7.736 608.

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circulation.100:736–742. doi: 10.1161/01.cir.100.7.736 608.. ### Response: 1999.


Instruction: Factor VIII, protein C and cardiovascular disease risk: what study?

Output: REasons for Geographic and Racial Differences in Stroke Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Factor VIII, protein C and cardiovascular disease risk: what study?. ### Response: REasons for Geographic and Racial Differences in Stroke Study.


Instruction: What is the acronym for the Racial Differences in Stroke Study?

Output: REGARDS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the Racial Differences in Stroke Study?. ### Response: REGARDS.


Instruction: Thromb Haemost. 2018;118:1305–1315. doi: 10.1055/s-0038-1655766 609.

Output: .1055/s-0038-1655766 609. Nakashima MO, Rogers HJ. Hypercoagulable states: an algorithmic ap-proach to laboratory testing and update on monitoring of direct oral antico-agulants. Blood Res. 2014;49:85–94. doi: 10.5045/br.2014.49.2.85 610

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Thromb Haemost. 2018;118:1305–1315. doi: 10.1055/s-0038-1655766 609.. ### Response: .1055/s-0038-1655766 609. Nakashima MO, Rogers HJ. Hypercoagulable states: an algorithmic ap-proach to laboratory testing and update on monitoring of direct oral antico-agulants. Blood Res. 2014;49:85–94. doi: 10.5045/br.2014.49.2.85 610.


Instruction: What is an algorithmic approach to laboratory testing and update on monitoring of direct oral antico-agulants?

Output: Hypercoagulable states

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an algorithmic approach to laboratory testing and update on monitoring of direct oral antico-agulants?. ### Response: Hypercoagulable states.


Instruction: What is the name of the thrombotic event in ischemic stroke patients with elevated factor VIII.Thrombosis. 2014;302861. doi:10.1155/2014/302860 611.

Output: New thrombotic events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the thrombotic event in ischemic stroke patients with elevated factor VIII.Thrombosis. 2014;302861. doi:10.1155/2014/302860 611.. ### Response: New thrombotic events.


Instruction: What is Lu AT, Szeto MD, Little A, Grinde KE, Shaw J, Auer PL?

Output: Raffield LM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Lu AT, Szeto MD, Little A, Grinde KE, Shaw J, Auer PL?. ### Response: Raffield LM.


Instruction: What does increased arterial stiffness do to SBP?

Output: increasing pulse-wave velocity and altering wave reflection from the periphery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does increased arterial stiffness do to SBP?. ### Response: increasing pulse-wave velocity and altering wave reflection from the periphery.


Instruction: What is generated with each ejection of blood from the LV?

Output: a pressure (pulse) wave

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is generated with each ejection of blood from the LV?. ### Response: a pressure (pulse) wave.


Instruction: What is generated and travels from the heart to the periphery at a pulse-wave velocity?

Output: a pressure (pulse) wave

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is generated and travels from the heart to the periphery at a pulse-wave velocity?. ### Response: a pressure (pulse) wave.


Instruction: What depends on the elastic properties of the conduit arteries?

Output: a pressure (pulse) wave is generated and travels from the heart to the periphery at a pulse-wave velocity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What depends on the elastic properties of the conduit arteries?. ### Response: a pressure (pulse) wave is generated and travels from the heart to the periphery at a pulse-wave velocity.


Instruction: The pulse wave is reflected at any point of discontinuity in what?

Output: the arterial tree

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The pulse wave is reflected at any point of discontinuity in what?. ### Response: the arterial tree.


Instruction: What determines the timing of the wave reflection?

Output: The elastic properties and length of the conduit arteries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What determines the timing of the wave reflection?. ### Response: The elastic properties and length of the conduit arteries.


Instruction: In younger people, the pulse-wave velocity is sufficiently slow that the reflected wave reaches the aortic valve after closure?

Output: ≈ 5 m/s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In younger people, the pulse-wave velocity is sufficiently slow that the reflected wave reaches the aortic valve after closure?. ### Response: ≈ 5 m/s.


Instruction: What happens to the aortic valve after closure?

Output: loses its vasodilator capacity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What happens to the aortic valve after closure?. ### Response: loses its vasodilator capacity.


Instruction: What does the boosting effect do to the coronary perfusion?

Output: enhancing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the boosting effect do to the coronary perfusion?. ### Response: enhancing.


Instruction: In older people, pulse-wave velocity is greatly increased ( 20 m/s) because of what?

Output: central arterial stiffening

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In older people, pulse-wave velocity is greatly increased ( 20 m/s) because of what?. ### Response: central arterial stiffening.


Instruction: What happens when the reflective wave reaches the aortic valve before closure?

Output: higher SBP, pulse pressure, and afterload and a lower DBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What happens when the reflective wave reaches the aortic valve before closure?. ### Response: higher SBP, pulse pressure, and afterload and a lower DBP.


Instruction: What causes a higher SBP, pulse pressure, and afterload and a lower DBP?

Output: the reflective wave

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes a higher SBP, pulse pressure, and afterload and a lower DBP?. ### Response: the reflective wave.


Instruction: The increase in SBP increases what?

Output: cardiac metabolic require-ments

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The increase in SBP increases what?. ### Response: cardiac metabolic require-ments.


Instruction: What is closely related to SBP?

Output: Pulse pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is closely related to SBP?. ### Response: Pulse pressure.


Instruction: Pulse pressure is linked to CVD events, including MI and what other event?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Pulse pressure is linked to CVD events, including MI and what other event?. ### Response: stroke.


Instruction: What is an independent predictor of all-cause and cardiovas-cular mortality?

Output: Aortic stiff-ness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an independent predictor of all-cause and cardiovas-cular mortality?. ### Response: Aortic stiff-ness.


Instruction: What is an important contributor to BP elevation in people with vascular disease?

Output: nitric oxide and prostaglandin E1, and vasoconstrictors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an important contributor to BP elevation in people with vascular disease?. ### Response: nitric oxide and prostaglandin E1, and vasoconstrictors.


Instruction: What is characterized by an unfavorable balance between vasodilators, nitric oxide and prostaglandin E1?

Output: Endothelial DysfunctionEndothelial dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is characterized by an unfavorable balance between vasodilators, nitric oxide and prostaglandin E1?. ### Response: Endothelial DysfunctionEndothelial dysfunction.


Instruction: What is BP elevation in people with vascular disease?

Output: Endothelial dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is BP elevation in people with vascular disease?. ### Response: Endothelial dysfunction.


Instruction: What contributes to thrombosis and vascular occlusion?

Output: The injured endothelium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What contributes to thrombosis and vascular occlusion?. ### Response: The injured endothelium.


Instruction: Release of what promotes adhesion of circulat-ing mononuclear leukocytes to the vessel wall?

Output: chemotac-tic cytokines and adhesion molecules

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Release of what promotes adhesion of circulat-ing mononuclear leukocytes to the vessel wall?. ### Response: chemotac-tic cytokines and adhesion molecules.


Instruction: Mononuclear leukocytes to the vessel wall is what?

Output: circulat-ing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Mononuclear leukocytes to the vessel wall is what?. ### Response: circulat-ing.


Instruction: What underlies the atherosclerotic process?

Output: vascular inflammation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What underlies the atherosclerotic process?. ### Response: vascular inflammation.


Instruction: Inflammatory mediators activate what type of muscle cells?

Output: medial smooth

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Inflammatory mediators activate what type of muscle cells?. ### Response: medial smooth.


Instruction: What is the core of the atherosclerotic plaque?

Output: lipid-laden macrophages

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the core of the atherosclerotic plaque?. ### Response: lipid-laden macrophages.


Instruction: What do resident macrophages secrete in established lesions?

Output: metal-loproteinases and cathepsins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do resident macrophages secrete in established lesions?. ### Response: metal-loproteinases and cathepsins.


Instruction: The fibrous cap of the plaque may rupture and release what?

Output: tissue factor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The fibrous cap of the plaque may rupture and release what?. ### Response: tissue factor.


Instruction: What causes thrombosis, coronary occlusion, and acute MI?

Output: plaque rupture and the release of tissue factor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes thrombosis, coronary occlusion, and acute MI?. ### Response: plaque rupture and the release of tissue factor.


Instruction: What causes endothelial dysfunction and decreased nitric oxide avail-ance?

Output: vasodilators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes endothelial dysfunction and decreased nitric oxide avail-ance?. ### Response: vasodilators.


Instruction: Where does this guideline place T A73?

Output: QS21 and QS181

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where does this guideline place T A73?. ### Response: QS21 and QS181.


Instruction: What is pain or constricting discomfort that typically occurs in the fr ont of t he chest?

Output: Angina

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is pain or constricting discomfort that typically occurs in the fr ont of t he chest?. ### Response: Angina.


Instruction: What is t he main sympt om of angina?

Output: m yocardial ischaemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is t he main sympt om of angina?. ### Response: m yocardial ischaemia.


Instruction: What are some atypical symptoms of gastr ointestinal discomfort?

Output: breathlessness or nausea

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some atypical symptoms of gastr ointestinal discomfort?. ### Response: breathlessness or nausea.


Instruction: What is t he main sympt om of m yocardial ischaemia?

Output: Angina

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is t he main sympt om of m yocardial ischaemia?. ### Response: Angina.


Instruction: What is usually caused by b y atheroscler otic obstructiv e cor onar y artery disease?

Output: ial ischaemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is usually caused by b y atheroscler otic obstructiv e cor onar y artery disease?. ### Response: ial ischaemia.


Instruction: What percentage of men and 3% of women aged between 55 and 64 years have had angina?

Output: 8%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of men and 3% of women aged between 55 and 64 years have had angina?. ### Response: 8%.


Instruction: The Healt h Survey for England r epor ted that 8% of men have had what?

Output: angina

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The Healt h Survey for England r epor ted that 8% of men have had what?. ### Response: angina.


Instruction: How many people in England curr ently have or have had angina?

Output: almost 2  million

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people in England curr ently have or have had angina?. ### Response: almost 2  million.


Instruction: What are the figur es for men and women between 65 and 7 4 years?

Output: 14% and 8% r espectiv ely

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the figur es for men and women between 65 and 7 4 years?. ### Response: 14% and 8% r espectiv ely.


Instruction: What can be a significant impact on a person's quality of life?

Output: Being diagnosed with angina

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be a significant impact on a person's quality of life?. ### Response: Being diagnosed with angina.


Instruction: What is a chronic medical condition wit h a lo w but appr eciable incidence of?

Output: Stable angina

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a chronic medical condition wit h a lo w but appr eciable incidence of?. ### Response: Stable angina.


Instruction: What is the aim of management?

Output: t o stop or minimise sympt oms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the aim of management?. ### Response: t o stop or minimise sympt oms.


Instruction: What is t o stop or minimise symptoms?

Output: The aim of management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is t o stop or minimise symptoms?. ### Response: The aim of management.


Instruction: Management options include lif estyle advice, drug tr eatment and r evascularisation using what?

Output: percutaneous or sur gical t echniques

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Management options include lif estyle advice, drug tr eatment and r evascularisation using what?. ### Response: percutaneous or sur gical t echniques.


Instruction: Why is it difficult to analyze the comparative efficacy of diff erent t eatments for people with stable angina?

Output: because of t he adv ances in drug tr eatment and r evascularisation strat egies o ver several decades

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is it difficult to analyze the comparative efficacy of diff erent t eatments for people with stable angina?. ### Response: because of t he adv ances in drug tr eatment and r evascularisation strat egies o ver several decades.


Instruction: What is difficult for people wit h stable angina?

Output: Analysis of t he comparativ e efficacy of diff erent tr eatment s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is difficult for people wit h stable angina?. ### Response: Analysis of t he comparativ e efficacy of diff erent tr eatment s.


Instruction: What are the advances in drug tr eatment and r evascularisation strat egies o ver several decades?

Output: Percutaneous r evascularisation t echniques have developed, fr om balloon angioplasty t o bar e metal st ents and drug eluting st ents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the advances in drug tr eatment and r evascularisation strat egies o ver several decades?. ### Response: Percutaneous r evascularisation t echniques have developed, fr om balloon angioplasty t o bar e metal st ents and drug eluting st ents.


Instruction: When were trials of drug thr atement v ersus cor onar y artery bypass surgery carried out?

Output: 25  years ago

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When were trials of drug thr atement v ersus cor onar y artery bypass surgery carried out?. ### Response: 25  years ago.


Instruction: How many years ago were bypass surgery carried out?

Output: 25

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many years ago were bypass surgery carried out?. ### Response: 25.


Instruction: What were not used when teh patient had severe cor onar y artery disease?

Output: Statins and ot her secondar y prevention treatment s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were not used when teh patient had severe cor onar y artery disease?. ### Response: Statins and ot her secondar y prevention treatment s.


Instruction: What was not used when t he trials were carried out?

Output: Statins and ot her secondar y prevention treatment s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not used when t he trials were carried out?. ### Response: Statins and ot her secondar y prevention treatment s.


Instruction: What has a significant eff ect on morbidity and mor tality?

Output: t hese tr eatment s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has a significant eff ect on morbidity and mor tality?. ### Response: t hese tr eatment s.


Instruction: Percutaneous r evascularisation has developed, fr om what type of surgery?

Output: balloon angioplasty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Percutaneous r evascularisation has developed, fr om what type of surgery?. ### Response: balloon angioplasty.


Instruction: What is the difference between balloon angioplasty and drug eluting st ents?

Output: each is associat ed wit h reduced rat es

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between balloon angioplasty and drug eluting st ents?. ### Response: each is associat ed wit h reduced rat es.


Instruction: All trials, including trials of r evascularisation strat egies, have what effect?

Output: limited to people consider ed suitable f

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: All trials, including trials of r evascularisation strat egies, have what effect?. ### Response: limited to people consider ed suitable f.


Instruction: What has been limited to people considered suitable f or the int ervention rat her t han being r epresentativ e Stable angina: management (CG126) NICE 2022?

Output: All trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been limited to people considered suitable f or the int ervention rat her t han being r epresentativ e Stable angina: management (CG126) NICE 2022?. ### Response: All trials.


Instruction: What is the subject t o Notice of right s?

Output: All right s reserved

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the subject t o Notice of right s?. ### Response: All right s reserved.


Instruction: Last updat ed 25 August 2016?

Output: Page 4of 26

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Last updat ed 25 August 2016?. ### Response: Page 4of 26.


Instruction: What is the title of NICE 2018?

Output: Qualitative

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of NICE 2018?. ### Response: Qualitative.


Instruction: What are the Outcomes?

Output: Medi cine optimization and adherence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Outcomes?. ### Response: Medi cine optimization and adherence.


Instruction: What is the term for bradycardia?

Output: Dichot omous

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for bradycardia?. ### Response: Dichot omous.


Instruction: What is another term for dyskalaemia?

Output: hyper

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for dyskalaemia?. ### Response: hyper.


Instruction: How does telemonitoring compare to usual care?

Output: clinical and cost effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does telemonitoring compare to usual care?. ### Response: clinical and cost effectiveness.


Instruction: What does self-monitoring using telephone technology do in people with heart failure compared with usual care?

Output: clinical and cost effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does self-monitoring using telephone technology do in people with heart failure compared with usual care?. ### Response: clinical and cost effectiveness.


Instruction: What is the term for all-cause mortality during study (dichotomous)?

Output: Time to event

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for all-cause mortality during study (dichotomous)?. ### Response: Time to event.


Instruction: What should be present in the multidisciplinary teams involved in the outpatient or community based care of people with heart failure?

Output: competencies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be present in the multidisciplinary teams involved in the outpatient or community based care of people with heart failure?. ### Response: competencies.


Instruction: What is the term for unplanned hospitalization?

Output: Count rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for unplanned hospitalization?. ### Response: Count rate.


Instruction: What is another term for Dying in preferred place of death?

Output: palliative care patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for Dying in preferred place of death?. ### Response: palliative care patients.


Instruction: Hypotension, hyperkalaemia, and renal function?

Output: Adverse events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hypotension, hyperkalaemia, and renal function?. ### Response: Adverse events.


Instruction: What are the experiences/preferences of staff and patients during transition between different heart failure care settings?

Output: Thematic analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the experiences/preferences of staff and patients during transition between different heart failure care settings?. ### Response: Thematic analysis.


Instruction: What is thematic analysis - information synthesised into main review findings?

Output: Qualitative

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is thematic analysis - information synthesised into main review findings?. ### Response: Qualitative.


Instruction: What are the information and support needs to be considered when communication a diagnosis and consequent prognosis?

Output: Qualitative

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the information and support needs to be considered when communication a diagnosis and consequent prognosis?. ### Response: Qualitative.


Instruction: What is the term for information synthesised into main review findings?

Output: Thematic analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for information synthesised into main review findings?. ### Response: Thematic analysis.


Instruction: Which route of administration of diuretics is most clinically and cost effective in people with advanced heart failure who are in the community?

Output: subcutaneous or oral

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which route of administration of diuretics is most clinically and cost effective in people with advanced heart failure who are in the community?. ### Response: subcutaneous or oral.


Instruction: What is one of the critical outcomes?

Output: Medi cine optimization and adherence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the critical outcomes?. ### Response: Medi cine optimization and adherence.


Instruction: What is another important outcome?

Output: Medi cine optimization and adherence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another important outcome?. ### Response: Medi cine optimization and adherence.


Instruction: How is dyspnoea treated?

Output: Thematic analysis - information synthesised into main review findings.  9 Qualitative  What are the information and support needs to b e considered when communication a diagnosis and consequent prognosis, to people with heart failure, their families and carers?  Thematic analysis - information synthesised into main review findings.  10 Intervention  Which route of administration of diuretics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is dyspnoea treated?. ### Response: Thematic analysis - information synthesised into main review findings.  9 Qualitative  What are the information and support needs to b e considered when communication a diagnosis and consequent prognosis, to people with heart failure, their families and carers?  Thematic analysis - information synthesised into main review findings.  10 Intervention  Which route of administration of diuretics.


Instruction: What is the 2017 ACC/AHA/HFSA Heart Failure Focused UpdateCirculation. 2017;136:e137–e161. DOI: 10.1161/CIR.0000000000000509 August 8, 2017 e153CLINICAL STATEMENTS AND GUIDELINES 85. Ledwidge M, Gallagher J, Conlon C, et al. What was the STOP-HF random-ized trial?

Output: Natriuretic peptide-based screening and collaborative care for heart failure: the STOP-HF random-ized trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2017 ACC/AHA/HFSA Heart Failure Focused UpdateCirculation. 2017;136:e137–e161. DOI: 10.1161/CIR.0000000000000509 August 8, 2017 e153CLINICAL STATEMENTS AND GUIDELINES 85. Ledwidge M, Gallagher J, Conlon C, et al. What was the STOP-HF random-ized trial?. ### Response: Natriuretic peptide-based screening and collaborative care for heart failure: the STOP-HF random-ized trial.


Instruction: What does PONTIAC stand for?

Output: NT-proBNP selected prevention of cardiac events in a population of diabetic patients without a history of cardiac disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does PONTIAC stand for?. ### Response: NT-proBNP selected prevention of cardiac events in a population of diabetic patients without a history of cardiac disease.


Instruction: What is the name of the prospective randomized controlled trial?

Output: PONTIAC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective randomized controlled trial?. ### Response: PONTIAC.


Instruction: How many diabetic patients have a history of cardiac disease?

Output: 89

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many diabetic patients have a history of cardiac disease?. ### Response: 89.


Instruction: What is the name of the Valsartan Heart Failure Trial?

Output: Val-HeFT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Valsartan Heart Failure Trial?. ### Response: Val-HeFT.


Instruction: What does Val-HeFT stand for?

Output: Valsartan Heart Failure Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Val-HeFT stand for?. ### Response: Valsartan Heart Failure Trial.


Instruction: How does B-type natriuretic peptide pre-dict sudden death in patients with chronic heart failure?

Output: prediction of death at dif-ferent stages of the disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does B-type natriuretic peptide pre-dict sudden death in patients with chronic heart failure?. ### Response: prediction of death at dif-ferent stages of the disease.


Instruction: What does natriuretic peptide pre-dict in patients with chronic heart failure?

Output: sudden death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does natriuretic peptide pre-dict in patients with chronic heart failure?. ### Response: sudden death.


Instruction: When did Circulation. 2002:105:2392-7?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circulation. 2002:105:2392-7?. ### Response: 2003.


Instruction: What is the relationship between B-type natruri-uretic Peptides and pulmonary capillary wedge pressure in the intensive care unit?

Output: Relationship

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the relationship between B-type natruri-uretic Peptides and pulmonary capillary wedge pressure in the intensive care unit?. ### Response: Relationship.


Instruction: What are independent risk factors for morbidity and mortality in patients with congestive heart failure?

Output: uretic peptide and interleukin-6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are independent risk factors for morbidity and mortality in patients with congestive heart failure?. ### Response: uretic peptide and interleukin-6.


Instruction: What is the name of the study that found high levels of plasma brain natri-uretic peptide and interleukin-6?

Output: Rapid Emergency Department Heart Failure Outpatient Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that found high levels of plasma brain natri-uretic peptide and interleukin-6?. ### Response: Rapid Emergency Department Heart Failure Outpatient Trial.


Instruction: What is the name of the peptide used in the prediction of death at different stages of heart failure?

Output: B-type natriuretic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the peptide used in the prediction of death at different stages of heart failure?. ### Response: B-type natriuretic.


Instruction: When did the J Am Coll Cardiol. 2000 issue 36:1587–93?

Output: 2000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the J Am Coll Cardiol. 2000 issue 36:1587–93?. ### Response: 2000.


Instruction: What does N-terminal-pro-brain natri-uretic peptide predict after hospital discharge in heart failure?

Output: outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does N-terminal-pro-brain natri-uretic peptide predict after hospital discharge in heart failure?. ### Response: outcome.


Instruction: What is the name of the drug used to predict hemodynamic and clinical decompensation?

Output: B-type natriuretic peptide levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used to predict hemodynamic and clinical decompensation?. ### Response: B-type natriuretic peptide levels.


Instruction: How does natri-uretic peptide predict outcome after hospital discharge in heart failure patients?

Output: N-terminal-pro-brain

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does natri-uretic peptide predict outcome after hospital discharge in heart failure patients?. ### Response: N-terminal-pro-brain.


Instruction: What is the name of the study that predicts treatment outcomes in patients admitted for decompensated heart failure?

Output: a pilot study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that predicts treatment outcomes in patients admitted for decompensated heart failure?. ### Response: a pilot study.


Instruction: How did Cheng V, Kazanagra R, Garcia A, et al. determine treatment outcomes?

Output: A rapid bedside test

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Cheng V, Kazanagra R, Garcia A, et al. determine treatment outcomes?. ### Response: A rapid bedside test.


Instruction: What is used to predict in-hospital mortality from ADHERE?

Output: B-type natri-uretic peptide and cardiac troponin levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used to predict in-hospital mortality from ADHERE?. ### Response: B-type natri-uretic peptide and cardiac troponin levels.


Instruction: What is the name of the pilot study?

Output: PONTIAC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the pilot study?. ### Response: PONTIAC.


Instruction: When was the J Am Coll Cardiol.37:386-91?

Output: 2001

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol.37:386-91?. ### Response: 2001.


Instruction: What is the name of the rapid emergency department heart failure outpatient trial?

Output: REDHOT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the rapid emergency department heart failure outpatient trial?. ### Response: REDHOT.


Instruction: What type of peptide assay is used to identify patients at high risk of re-admission?

Output: B-type natriuretic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of peptide assay is used to identify patients at high risk of re-admission?. ### Response: B-type natriuretic.


Instruction: What is the acronym for Rapid Emergency Department Heart Failure Outpatient Trial?

Output: REDHOT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Rapid Emergency Department Heart Failure Outpatient Trial?. ### Response: REDHOT.


Instruction: What is REDHOT?

Output: Rapid Emergency Department Heart Failure Outpatient Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is REDHOT?. ### Response: Rapid Emergency Department Heart Failure Outpatient Trial.


Instruction: A multi-center study of what?

Output: B-type natriuretic peptide levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A multi-center study of what?. ### Response: B-type natriuretic peptide levels.


Instruction: What did the Penumbra Separator 3D Trial compare to aspiration alone as first-line intracranial mechanical thrombectomy for successful revascularization within 8 hours among patients with AIS (NIHSS score of at least 8) and LVO refractory to or ineligible for IV alteplase in a 1:1 ratio?

Output: noninferiority

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Penumbra Separator 3D Trial compare to aspiration alone as first-line intracranial mechanical thrombectomy for successful revascularization within 8 hours among patients with AIS (NIHSS score of at least 8) and LVO refractory to or ineligible for IV alteplase in a 1:1 ratio?. ### Response: noninferiority.


Instruction: What was the noninferiority margin for IV alteplase?

Output: 15%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the noninferiority margin for IV alteplase?. ### Response: 15%.


Instruction: What percentage of mTICI grade 2 to 3 occurred in the combination group versus 82.3% in the aspiration alone group?

Output: 87.2%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of mTICI grade 2 to 3 occurred in the combination group versus 82.3% in the aspiration alone group?. ### Response: 87.2%.


Instruction: What was the noninferiority criterion of lower 90% confidence bound less than 15%?

Output: primary end point of mTICI grade 2 to 3 occurred in 87.2% of the combination group versus 82.3% in the aspiration alone group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the noninferiority criterion of lower 90% confidence bound less than 15%?. ### Response: primary end point of mTICI grade 2 to 3 occurred in 87.2% of the combination group versus 82.3% in the aspiration alone group.


Instruction: How long was the mRS score of aspiration alone group?

Output: 90-day

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the mRS score of aspiration alone group?. ### Response: 90-day.


Instruction: What did the trial not demonstrate in the secondary?

Output: noninferiority

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the trial not demonstrate in the secondary?. ### Response: noninferiority.


Instruction: What was not powered to demonstrate noninferiority in the secondary outcome of 90-day functional independence?

Output: The Penumbra Separator 3D Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not powered to demonstrate noninferiority in the secondary outcome of 90-day functional independence?. ### Response: The Penumbra Separator 3D Trial.


Instruction: What is Table XVII in online Data Supplement 1.3?

Output: Although the benefits are uncertain

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Table XVII in online Data Supplement 1.3?. ### Response: Although the benefits are uncertain.


Instruction: Why is the use of mechanical thrombectomy with stent retrievers reasonable?

Output: successful revascularization within 8 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is the use of mechanical thrombectomy with stent retrievers reasonable?. ### Response: successful revascularization within 8 hours.


Instruction: How long after symptom onset can treatment be initiated for patients with AIS?

Output: 6 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after symptom onset can treatment be initiated for patients with AIS?. ### Response: 6 hours.


Instruction: What is a causative occlusion of the MCA segment 2?

Output: M2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a causative occlusion of the MCA segment 2?. ### Response: M2.


Instruction: What year was COR reworded for clarity?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was COR reworded for clarity?. ### Response: 2015.


Instruction: What was revised for clarity from 2015 Endovascular?

Output: IIb B-RRecommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was revised for clarity from 2015 Endovascular?. ### Response: IIb B-RRecommendation.


Instruction: Where is Table XCV from?

Output: online Data Supplement 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Table XCV from?. ### Response: online Data Supplement 1.


Instruction: How many trials were pooled from 5 trials?

Output: 5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many trials were pooled from 5 trials?. ### Response: 5.


Instruction: What was the direction of treatment effect for mechanical thrombectomy over standard care?

Output: favorable

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the direction of treatment effect for mechanical thrombectomy over standard care?. ### Response: favorable.


Instruction: What was not significant in M2 occlusions?

Output: the OR and 95% CI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not significant in M2 occlusions?. ### Response: the OR and 95% CI.


Instruction: Which device was the only or the predominant device used?

Output: Solitaire

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which device was the only or the predominant device used?. ### Response: Solitaire.


Instruction: What did SEER Collaboration: SWIFT PRIME, ESCAPE, EXTEND-IA, and REVASCAT show was favorable for mechanical thrombectomy over standard care in M2 occlusions?

Output: direction of treatment effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did SEER Collaboration: SWIFT PRIME, ESCAPE, EXTEND-IA, and REVASCAT show was favorable for mechanical thrombectomy over standard care in M2 occlusions?. ### Response: direction of treatment effect.


Instruction: What was not significant?

Output: the OR and 95% CI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not significant?. ### Response: the OR and 95% CI.


Instruction: What is SWIFT?

Output: Solitaire With the Intention for Thrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SWIFT?. ### Response: Solitaire With the Intention for Thrombectomy.


Instruction: What is STAR?

Output: Solitaire Flow Restoration Thrombectomy for Acute Revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is STAR?. ### Response: Solitaire Flow Restoration Thrombectomy for Acute Revascularization.


Instruction: In an analysis of pooled data, what was associated with excellent functional outcomes?

Output: reperfusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In an analysis of pooled data, what was associated with excellent functional outcomes?. ### Response: reperfusion.


Instruction: What is the mRS score for M2/M3 occlusions?

Output: 0–1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the mRS score for M2/M3 occlusions?. ### Response: 0–1.


Instruction: The recommendation for mechanical thrombectomy does not change from the 2015 AHA/ASA focused update?

Output: COR unchanged

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The recommendation for mechanical thrombectomy does not change from the 2015 AHA/ASA focused update?. ### Response: COR unchanged.


Instruction: What is a surrogate marker for the extent of coronaryatherosclerosis?

Output: Angiographic severityof coronary narrowing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a surrogate marker for the extent of coronaryatherosclerosis?. ### Response: Angiographic severityof coronary narrowing.


Instruction: What is the prognostic value of acoronary artery jeopardy score?

Output: –42.386

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the prognostic value of acoronary artery jeopardy score?. ### Response: –42.386.


Instruction: What is the effect of aortocoronary bypass surgery on the survival of patients with left main coronary arterydisease?

Output: Comparison of surgical andmedical group survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of aortocoronary bypass surgery on the survival of patients with left main coronary arterydisease?. ### Response: Comparison of surgical andmedical group survival.


Instruction: What was the name of the study that examined the effects of bypass surgery in patients with a left major coronaryartery disease?

Output: Circulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the study that examined the effects of bypass surgery in patients with a left major coronaryartery disease?. ### Response: Circulation.


Instruction: In what year was Circulation published?

Output: 1978

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was Circulation published?. ### Response: 1978.


Instruction: What is the prognostic spectrum of leftmain stenosis?

Output: angiographic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the prognostic spectrum of leftmain stenosis?. ### Response: angiographic.


Instruction: What is Cameron A, Kemp HG Jr, Fisher LD, et al.?

Output: Left main coronary arterystenosis: angiographic determination

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Cameron A, Kemp HG Jr, Fisher LD, et al.?. ### Response: Left main coronary arterystenosis: angiographic determination.


Instruction: What is angiographic determination used for?

Output: the extent of coronaryatherosclerosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is angiographic determination used for?. ### Response: the extent of coronaryatherosclerosis.


Instruction: What is Accuracy of Angiographic deter-mination of left main coronary arterial narrowing?

Output: histologic correlative analysis in 28 patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Accuracy of Angiographic deter-mination of left main coronary arterial narrowing?. ### Response: histologic correlative analysis in 28 patients.


Instruction: What is the term for the dissociation between clinical and angiographic findings in ische-mic heart disease?

Output: coronary luminology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for the dissociation between clinical and angiographic findings in ische-mic heart disease?. ### Response: coronary luminology.


Instruction: When did Circulation issue 92:2333-42.386?

Output: 1995

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circulation issue 92:2333-42.386?. ### Response: 1995.


Instruction: What did West JN, Bennett MR, Pentecost BL associate with stenosis of the main stem of theleft coronary artery?

Output: transient abnormalQ-waves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did West JN, Bennett MR, Pentecost BL associate with stenosis of the main stem of theleft coronary artery?. ### Response: transient abnormalQ-waves.


Instruction: What type of coronary artery disease is compared to exercise performance?

Output: three-vessel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of coronary artery disease is compared to exercise performance?. ### Response: three-vessel.


Instruction: What is the difference between left main and three-vessel coronary arterial disease?

Output: exerciseperformance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between left main and three-vessel coronary arterial disease?. ### Response: exerciseperformance.


Instruction: What year did Chest.100:227–9.389.

Output: 1991

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Chest.100:227–9.389.. ### Response: 1991.


Instruction: What was Morris SN, Phillips JF, Jordan JW, et al. Incidence and significance of decreases in systolic blood pressure during graded treadmill exercisetesting?

Output: Morris SN

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was Morris SN, Phillips JF, Jordan JW, et al. Incidence and significance of decreases in systolic blood pressure during graded treadmill exercisetesting?. ### Response: Morris SN.


Instruction: What year was Am J Cardiol.41:221–6.390?

Output: 1978

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was Am J Cardiol.41:221–6.390?. ### Response: 1978.


Instruction: What causes leftmain coronary artery disease in unstable angina?

Output: aortocoronary bypass surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes leftmain coronary artery disease in unstable angina?. ### Response: aortocoronary bypass surgery.


Instruction: What year did Ford ES, Ajani UA, Croft JB, et al. explain the decrease in U.S.deaths from coronary disease?

Output: 1980–2000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Ford ES, Ajani UA, Croft JB, et al. explain the decrease in U.S.deaths from coronary disease?. ### Response: 1980–2000.


Instruction: How many countries have the INTERHEART study?

Output: 52

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many countries have the INTERHEART study?. ### Response: 52.


Instruction: What is the name of the case-control study in which risk factors are associated with myocardial infarction?

Output: INTERHEART study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the case-control study in which risk factors are associated with myocardial infarction?. ### Response: INTERHEART study.


Instruction: How many patients with coronary heart disease were included in the Randomised trial of cholesterol lowering?

Output: 4444

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with coronary heart disease were included in the Randomised trial of cholesterol lowering?. ### Response: 4444.


Instruction: What was the name of the randomised trial of cholesterol lowering in 4444 patients withcoronary heart disease?

Output: Scandinavian Simvastatin Survival Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the randomised trial of cholesterol lowering in 4444 patients withcoronary heart disease?. ### Response: Scandinavian Simvastatin Survival Study.


Instruction: When was the Lancet 344:1383–9.395.

Output: 1994

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Lancet 344:1383–9.395.. ### Response: 1994.


Instruction: What is the effect of pravastatin on cholesterol?

Output: lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of pravastatin on cholesterol?. ### Response: lowering.


Instruction: What factors favor PCI over CABG include limited areas of ischemia causing symp-toms?

Output: suitable PCI targets, a patent graft to the LAD artery,poor CABG targets, and comorbid conditions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What factors favor PCI over CABG include limited areas of ischemia causing symp-toms?. ### Response: suitable PCI targets, a patent graft to the LAD artery,poor CABG targets, and comorbid conditions.


Instruction: What are some factors favoring PCIover CABG?

Output: limited areas of ischemia causing symp-toms, suitable PCI targets, a patent graft to the LAD artery,poor CABG targets, and comorbid conditions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some factors favoring PCIover CABG?. ### Response: limited areas of ischemia causing symp-toms, suitable PCI targets, a patent graft to the LAD artery,poor CABG targets, and comorbid conditions.


Instruction: What is the main difference between management of SIHD and the patient with UA/NSTEMI?

Output: the impetusfor revascularization is stronger

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the main difference between management of SIHD and the patient with UA/NSTEMI?. ### Response: the impetusfor revascularization is stronger.


Instruction: What is potentially life threatening?

Output: myocardial ischemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is potentially life threatening?. ### Response: myocardial ischemia.


Instruction: How is the impetus for revascularization stronger?

Output: in the setting of UA/NSTEMI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the impetus for revascularization stronger?. ### Response: in the setting of UA/NSTEMI.


Instruction: What type of ACS is potentially life threatening?

Output: myocardial ischemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of ACS is potentially life threatening?. ### Response: myocardial ischemia.


Instruction: What is more likely to be reduced with a revascularization procedure than with GDMT?

Output: anginalsymptoms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more likely to be reduced with a revascularization procedure than with GDMT?. ### Response: anginalsymptoms.


Instruction: The indica-tions for what are strengthened by the acuity ofpresentation and the extent of ischemia?

Output: revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The indica-tions for what are strengthened by the acuity ofpresentation and the extent of ischemia?. ### Response: revascularization.


Instruction: What type of revascularization is generally dictated by the same considerations used to decide on PCI or CABG for patients with SIHD?

Output: The choice of revascularization method

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of revascularization is generally dictated by the same considerations used to decide on PCI or CABG for patients with SIHD?. ### Response: The choice of revascularization method.


Instruction: What is the recommendationclass III: HARM1?

Output: DAPT Compliance and StentThrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommendationclass III: HARM1?. ### Response: DAPT Compliance and StentThrombosis.


Instruction: What is increased dramatically inpatients who prematurely discontinue DAPT?

Output: The risk of stent thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is increased dramatically inpatients who prematurely discontinue DAPT?. ### Response: The risk of stent thrombosis.


Instruction: What is associated with a stentthrombosis?

Output: mortality rate of 20% to45%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with a stentthrombosis?. ### Response: mortality rate of 20% to45%..


Instruction: What is associated with a mortality rate of 20% to45%?

Output: stentthrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with a mortality rate of 20% to45%?. ### Response: stentthrombosis.


Instruction: What is the generally recommended minimum duration of DAPT therapy for DESpatients?

Output: 14 to 30 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the generally recommended minimum duration of DAPT therapy for DESpatients?. ### Response: 14 to 30 days.


Instruction: Why is the risk of stent thrombosis greatest in the first 14 to 30 days?

Output: this is the generallyrecommended minimum duration of DAPT therapy for theseindividuals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is the risk of stent thrombosis greatest in the first 14 to 30 days?. ### Response: this is the generallyrecommended minimum duration of DAPT therapy for theseindividuals.


Instruction: What is the consensus in clinical practice to treat DESpatients for at least 12 months with DAPT to avoid late (after30 days) stent thrombosis?

Output: Consensus in clinical practice is to treat DESpatients for at least 12 months with DAPT to avoid late (after30 days) stent thrombosis.497,501

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the consensus in clinical practice to treat DESpatients for at least 12 months with DAPT to avoid late (after30 days) stent thrombosis?. ### Response: Consensus in clinical practice is to treat DESpatients for at least 12 months with DAPT to avoid late (after30 days) stent thrombosis.497,501.


Instruction: What is an important consideration in deciding whether to use PCI to treat patients with CAD?

Output: the ability of thepatient to tolerate and comply with at least 30 days of DAPTwith BMS treatment and at least 12 months of DAPT withDES treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an important consideration in deciding whether to use PCI to treat patients with CAD?. ### Response: the ability of thepatient to tolerate and comply with at least 30 days of DAPTwith BMS treatment and at least 12 months of DAPT withDES treatment.


Instruction: What has been used on occasion in patients with severeangina refractory to GDMT in whom complete revascularization cannot be achieved?

Output: TMR as an Adjunct to CABGTMR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been used on occasion in patients with severeangina refractory to GDMT in whom complete revascularization cannot be achieved?. ### Response: TMR as an Adjunct to CABGTMR.


Instruction: What is the mechanism by which TMR might be efficacious in GDMT?

Output: unknown

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the mechanism by which TMR might be efficacious in GDMT?. ### Response: unknown.


Instruction: How many RCTs of TMR as soletherapy demonstrated a reduction in anginal symptoms com-pared with intensive medical therapy alone?

Output: 502,503

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs of TMR as soletherapy demonstrated a reduction in anginal symptoms com-pared with intensive medical therapy alone?. ### Response: 502,503.


Instruction: How much reduction in perioperative mortality rate did the TMR-CABG comparison show?

Output: 1.5% versus7.6%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much reduction in perioperative mortality rate did the TMR-CABG comparison show?. ### Response: 1.5% versus7.6%,.


Instruction: What was the survival benefit of TMR and CABG?

Output: after 1 year of follow-up

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the survival benefit of TMR and CABG?. ### Response: after 1 year of follow-up.


Instruction: How many sub-jects were treated with TMR plus CABG plus TMR?

Output: 397–399,504–506

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many sub-jects were treated with TMR plus CABG plus TMR?. ### Response: 397–399,504–506.


Instruction: What was the survival benefit of the TMR-CABG combination after 1 year of follow-up?

Output: reduction in perioperative mortality rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the survival benefit of the TMR-CABG combination after 1 year of follow-up?. ### Response: reduction in perioperative mortality rate.


Instruction: What is the name of the study that investigated the relationship between structure and function of heparin?

Output: Thromb Haemost

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the relationship between structure and function of heparin?. ### Response: Thromb Haemost.


Instruction: How many papers were published in 1979?

Output: 1218 - 1222

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many papers were published in 1979?. ### Response: 1218 - 1222.


Instruction: What is the name of the 8th edition of American College of Chest Physicians evidence-based clinical practice guidelines?

Output: Parenteral anticoagu-lants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 8th edition of American College of Chest Physicians evidence-based clinical practice guidelines?. ### Response: Parenteral anticoagu-lants.


Instruction: What is heparin fractionated by affi nity chromatography on matrix-bound antithrombin iii?

Output: Anticoagulant properties

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is heparin fractionated by affi nity chromatography on matrix-bound antithrombin iii?. ### Response: Anticoagulant properties.


Instruction: What is fractionated by affi nity chromatography on matrix-bound antithrombin iii and by gel fi ltration?

Output: Anticoagulant properties of heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is fractionated by affi nity chromatography on matrix-bound antithrombin iii and by gel fi ltration?. ### Response: Anticoagulant properties of heparin.