Instruction: What did ACEi reduce inpatients with severely increased albuminuria?

Output: doubling of serum creatinine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did ACEi reduce inpatients with severely increased albuminuria?. ### Response: doubling of serum creatinine.


Instruction: How many participants participated in 2 studies?

Output: 441

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many participants participated in 2 studies?. ### Response: 441.


Instruction: How many patients were in 17 studies with a mean follow-up?

Output: 2036

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were in 17 studies with a mean follow-up?. ### Response: 2036.


Instruction: What is the risk of progression from moderate to severe albuminuria?

Output: decreased by55%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of progression from moderate to severe albuminuria?. ### Response: decreased by55%.


Instruction: How long was the mean follow-up of ARBs?

Output: 34 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the mean follow-up of ARBs?. ### Response: 34 months.


Instruction: How many patients had a mean follow up of 34 months?

Output: 3280

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had a mean follow up of 34 months?. ### Response: 3280.


Instruction: What was the difference in events per 1000 patients?

Output: 123 fewer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the difference in events per 1000 patients?. ### Response: 123 fewer.


Instruction: In 8 studies, how many participants were in the study?

Output: 4106

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In 8 studies, how many participants were in the study?. ### Response: 4106.


Instruction: What did not show a difference in all-causemortality in patients with diabetes and CKD?

Output: ARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did not show a difference in all-causemortality in patients with diabetes and CKD?. ### Response: ARBs.


Instruction: What was a kidney bene fit with a reduction of doubling of ofserum creatinine?

Output: 16%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a kidney bene fit with a reduction of doubling of ofserum creatinine?. ### Response: 16%.


Instruction: What was the RR of kidney bene fit?

Output: 0.84

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the RR of kidney bene fit?. ### Response: 0.84.


Instruction: How long was the mean follow-up of 3280 patients?

Output: 34months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the mean follow-up of 3280 patients?. ### Response: 34months.


Instruction: What were the outcomes of all-cause mortality?

Output: discrete outcomes of all-cause mortality, CV mortality, MI,stroke, HF, and kidney function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the outcomes of all-cause mortality?. ### Response: discrete outcomes of all-cause mortality, CV mortality, MI,stroke, HF, and kidney function.


Instruction: What does ACEi improve in patients with CKD?

Output: CV outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ACEi improve in patients with CKD?. ### Response: CV outcomes.


Instruction: What is the difference between ARB and standard of care?

Output: there is no improvement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between ARB and standard of care?. ### Response: there is no improvement.


Instruction: What may have had aninsufficient number of patients to find a difference?

Output: 123 fewer events per 1000 patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may have had aninsufficient number of patients to find a difference?. ### Response: 123 fewer events per 1000 patients.


Instruction: What has little evidence to support the use of other agents?

Output: MRA, beta-blockers, and CCBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has little evidence to support the use of other agents?. ### Response: MRA, beta-blockers, and CCBs.


Instruction: How many small short-term studies were powered for changes in albuminuria?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many small short-term studies were powered for changes in albuminuria?. ### Response: 3.


Instruction: What was lowered by MRA?

Output: Albuminuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was lowered by MRA?. ### Response: Albuminuria.


Instruction: What did the ERT show about RCTs on all-cause mortality, MI, and stroke?

Output: there was no bene-ﬁcial effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the ERT show about RCTs on all-cause mortality, MI, and stroke?. ### Response: there was no bene-ﬁcial effect.


Instruction: What was not powered for?

Output: CV orkidney outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not powered for?. ### Response: CV orkidney outcomes.


Instruction: How did meta-analysis show?

Output: no evi-

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did meta-analysis show?. ### Response: no evi-.


Instruction: What are beta-blockers and CCBs compared to?

Output: placebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are beta-blockers and CCBs compared to?. ### Response: placebo.


Instruction: What is the effect of bene fits on CV or kidney outcomes?

Output: reduction of doubling ofserum creatinine of 16%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of bene fits on CV or kidney outcomes?. ### Response: reduction of doubling ofserum creatinine of 16%.


Instruction: Sodium intake among persons aged 2 years — United States, 2013 – 2014?

Output: 131

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Sodium intake among persons aged 2 years — United States, 2013 – 2014?. ### Response: 131.


Instruction: MMWR Morb Mortal Wkly Rep. 2017 66(12):324 -238.

Output: 132

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: MMWR Morb Mortal Wkly Rep. 2017 66(12):324 -238.. ### Response: 132.


Instruction: What diet did Estruch R, Ros E, Salas -Salvado J, et al. study on?

Output: Mediterranean

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What diet did Estruch R, Ros E, Salas -Salvado J, et al. study on?. ### Response: Mediterranean.


Instruction: What did the BMC Med. Sep 19 2013:11:207?

Output: Results from a randomized controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the BMC Med. Sep 19 2013:11:207?. ### Response: Results from a randomized controlled trial.


Instruction: What is the primary prevention of cardiovascular disease with a Mediterranean diet?

Output: extra -virgin olive oil or nuts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary prevention of cardiovascular disease with a Mediterranean diet?. ### Response: extra -virgin olive oil or nuts.


Instruction: What does the Mediterranean diet supplement with extra -virgin olive oil do?

Output: Primary prevention of cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Mediterranean diet supplement with extra -virgin olive oil do?. ### Response: Primary prevention of cardiovascular disease.


Instruction: What is a Mediterranean diet supplemented with?

Output: extra -virgin olive oil or nuts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a Mediterranean diet supplemented with?. ### Response: extra -virgin olive oil or nuts.


Instruction: What is an extra-virgin olive oil or nuts supplement?

Output: Primary prevention of cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an extra-virgin olive oil or nuts supplement?. ### Response: Primary prevention of cardiovascular disease.


Instruction: What is the most common type of hypertensive drug?

Output: calcium channel blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common type of hypertensive drug?. ### Response: calcium channel blocker.


Instruction: What type of patients are treated with chlorthalidone, amlodipine, and lisinopril?

Output: hypertensive black and nonblack

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of patients are treated with chlorthalidone, amlodipine, and lisinopril?. ### Response: hypertensive black and nonblack.


Instruction: What is the name of the drug used to treat non-black patients?

Output: chlorthalidone, amlodipine, and lisinopril

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used to treat non-black patients?. ### Response: chlorthalidone, amlodipine, and lisinopril.


Instruction: What are the names of the drugs used in the treatment of hypertensive patients in the U.S.?

Output: chlorthalidone, amlodipine, and lisinopril

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the drugs used in the treatment of hypertensive patients in the U.S.?. ### Response: chlorthalidone, amlodipine, and lisinopril.


Instruction: What is the name of the trial to prevent heart attacks called?

Output: antihypertensive and lipid -lowe ring treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the trial to prevent heart attacks called?. ### Response: antihypertensive and lipid -lowe ring treatment.


Instruction: When did JAMA issue 288(23):2981-2997?

Output: Dec 18 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did JAMA issue 288(23):2981-2997?. ### Response: Dec 18 2002.


Instruction: What was the PMID for the trial?

Output: 15811979

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the PMID for the trial?. ### Response: 15811979.


Instruction: What is the difference between a calcium channel blocker and angiotensin converting enzyme inhibitor?

Output: diuretic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between a calcium channel blocker and angiotensin converting enzyme inhibitor?. ### Response: diuretic.


Instruction: What did the antihypertensive and lipid -lowe ring treatment to prevent heart attack trial involve?

Output: Clinical events in high -risk hypertensive patients randomly assigned to calcium channel blocker versus angiotensin -converting enzyme inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the antihypertensive and lipid -lowe ring treatment to prevent heart attack trial involve?. ### Response: Clinical events in high -risk hypertensive patients randomly assigned to calcium channel blocker versus angiotensin -converting enzyme inhibitor.


Instruction: When did Hypertension. Sep 2006;48(3):374-384.

Output: Clinical events in high -risk hypertensive patients randomly assigned to calcium channel blocker versus angiotensin -converting enzyme inhibitor in the antihypertensive and lipid -lowe ring treatment to prevent heart attack trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Hypertension. Sep 2006;48(3):374-384.. ### Response: Clinical events in high -risk hypertensive patients randomly assigned to calcium channel blocker versus angiotensin -converting enzyme inhibitor in the antihypertensive and lipid -lowe ring treatment to prevent heart attack trial.


Instruction: What study examined risk reduction in hypertensive black patients with left ventricular hypertrophy?

Output: The LIFE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What study examined risk reduction in hypertensive black patients with left ventricular hypertrophy?. ### Response: The LIFE.


Instruction: When was the LIFE study conducted?

Output: Mar 17 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the LIFE study conducted?. ### Response: Mar 17 2004.


Instruction: What is considered a first-line agent for BP control (Class IIa; Level of Evidence A)?

Output: 5. Aldosterone antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is considered a first-line agent for BP control (Class IIa; Level of Evidence A)?. ### Response: 5. Aldosterone antagonists.


Instruction: Aldosterone antagonists are indicated for patients who are already receiving  -blockers and ACE inhibitors after MI and have LV dysfunction and either HF or diabetes mellitus?

Output: 5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Aldosterone antagonists are indicated for patients who are already receiving  -blockers and ACE inhibitors after MI and have LV dysfunction and either HF or diabetes mellitus?. ### Response: 5.


Instruction: What must be monitored in patients with elevated serum creatinine levels?

Output: Serum potassium levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must be monitored in patients with elevated serum creatinine levels?. ### Response: Serum potassium levels.


Instruction: What is preferred over thiazide-type diuretics?

Output: Loop diuretics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is preferred over thiazide-type diuretics?. ### Response: Loop diuretics.


Instruction: What is preferred over thiazide-type diuretics for patients with ACS who have HF (NYHA class III or IV) or CKD and an estimated glomerular filtration rate 30 mL/min?

Output: Loop diuretics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is preferred over thiazide-type diuretics for patients with ACS who have HF (NYHA class III or IV) or CKD and an estimated glomerular filtration rate 30 mL/min?. ### Response: Loop diuretics.


Instruction: What is the target BP in patients with ACS who are hemodynamically stable?

Output: <140/90 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the target BP in patients with ACS who are hemodynamically stable?. ### Response: <140/90 mm Hg.


Instruction: What may be added in selected patients for BP control?

Output: a thiazide or thiazide-type diuretic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be added in selected patients for BP control?. ### Response: a thiazide or thiazide-type diuretic.


Instruction: In patients with ACS who are hemodynamically stable what is a reasonable op-tion?

Output: A BP target of <130/80 mm Hg at the time of hospital discharge

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with ACS who are hemodynamically stable what is a reasonable op-tion?. ### Response: A BP target of <130/80 mm Hg at the time of hospital discharge.


Instruction: What should be lowered slowly?

Output: The BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be lowered slowly?. ### Response: The BP.


Instruction: How is DBP lowered slowly?

Output: <60 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is DBP lowered slowly?. ### Response: <60 mm Hg.


Instruction: Why is it advised to avoid decreases in DBP to 60 mm Hg?

Output: because this may reduce coronary perfusion and worsen ischemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is it advised to avoid decreases in DBP to 60 mm Hg?. ### Response: because this may reduce coronary perfusion and worsen ischemia.


Instruction: What may reduce coronary perfusion and worsen ischemia?

Output: decreases in DBP to <60 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may reduce coronary perfusion and worsen ischemia?. ### Response: decreases in DBP to <60 mm Hg.


Instruction: Who have guidelines for the treatment of chronic HF?

Output: ACC and the AHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who have guidelines for the treatment of chronic HF?. ### Response: ACC and the AHA.


Instruction: How much evidence exists for the treatment of chronic HF?

Output: 177,209

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much evidence exists for the treatment of chronic HF?. ### Response: 177,209.


Instruction: What percentage of patients hospitalized with HF had hypertension?

Output: ≈75%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients hospitalized with HF had hypertension?. ### Response: ≈75%.


Instruction: What percent of patients hospitalized with HF had hypertension?

Output: ≈75%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percent of patients hospitalized with HF had hypertension?. ### Response: ≈75%.


Instruction: What percentage of patients had a history of hypertension in the Registry to Improve the Use of Evidence-Based Heart Failure Therapies in the Outpatient Setting?

Output: >60%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients had a history of hypertension in the Registry to Improve the Use of Evidence-Based Heart Failure Therapies in the Outpatient Setting?. ### Response: >60%.


Instruction: What did practices have a history of?

Output: hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did practices have a history of?. ### Response: hypertension.


Instruction: What data suggest a similar prevalence of hypertension in patients with ischemic cardiomyopathy?

Output: Duke Databank for Cardiovascular Disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What data suggest a similar prevalence of hypertension in patients with ischemic cardiomyopathy?. ### Response: Duke Databank for Cardiovascular Disease.


Instruction: What is a major risk factor for IHD?

Output: Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a major risk factor for IHD?. ### Response: Hypertension.


Instruction: What can lead to the development of HF?

Output: Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can lead to the development of HF?. ### Response: Hypertension.


Instruction: What causes LV hypertrophy, impaired cardiac myocyte contractility, ventricular chamber remodel-ing, and eventually ventricular dysfunction?

Output: Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes LV hypertrophy, impaired cardiac myocyte contractility, ventricular chamber remodel-ing, and eventually ventricular dysfunction?. ### Response: Hypertension.


Instruction: What are major risk fac-tors for the development of HF?

Output: Elevated levels of DBP and especially SBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are major risk fac-tors for the development of HF?. ### Response: Elevated levels of DBP and especially SBP.


Instruction: Long-term treatment of both systolic and diastlic hypertension has been shown to reduce the risk of what?

Output: HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Long-term treatment of both systolic and diastlic hypertension has been shown to reduce the risk of what?. ### Response: HF.


Instruction: What has been shown to reduce the risk of HF?

Output: long-term treatment of both systolic and diastolic hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been shown to reduce the risk of HF?. ### Response: long-term treatment of both systolic and diastolic hypertension.


Instruction: What is the subsequent structural abnor -

Output: 93,123,219

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the subsequent structural abnor -. ### Response: 93,123,219.


Instruction: What is the basis for the assumed risk?

Output: the median control group risk across studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the basis for the assumed risk?. ### Response: the median control group risk across studies.


Instruction: How many studies were conducted on recurrent VTE?

Output: 1,224

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were conducted on recurrent VTE?. ### Response: 1,224.


Instruction: What was the median control group risk of major bleeding?

Output: assumed risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the median control group risk of major bleeding?. ### Response: assumed risk.


Instruction: What is provided in the footnotes?

Output: group risk across studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is provided in the footnotes?. ### Response: group risk across studies.


Instruction: What is based on the assumed risk in the comparison group and relative effect of the intervention?

Output: The corresponding risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is based on the assumed risk in the comparison group and relative effect of the intervention?. ### Response: The corresponding risk.


Instruction: What is the HR 14hazard ratio?

Output: ¼

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the HR 14hazard ratio?. ### Response: ¼.


Instruction: What is another name for the Warfarin and Aspirin study?

Output: WARFASA ¼Aspirin for the Prevention of Recurrent Venous Thromboembolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for the Warfarin and Aspirin study?. ### Response: WARFASA ¼Aspirin for the Prevention of Recurrent Venous Thromboembolism.


Instruction: What is the legend for expansion of otherabbreviations and GRADE Working Group grades of evidence?

Output: Table 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the legend for expansion of otherabbreviations and GRADE Working Group grades of evidence?. ### Response: Table 1.


Instruction: What study was stopped early and included only one-third of the intended patients?

Output: Brighton et al70

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What study was stopped early and included only one-third of the intended patients?. ### Response: Brighton et al70.


Instruction: What is Simes et al72(INSPIRE)?

Output: International Collaboration of Aspirin Trials for Recurrent Venous Thromboembolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Simes et al72(INSPIRE)?. ### Response: International Collaboration of Aspirin Trials for Recurrent Venous Thromboembolism.


Instruction: What is the name of the synthesis of Brighton and Becattini?

Output: Brighton et al70(ASPIRE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the synthesis of Brighton and Becattini?. ### Response: Brighton et al70(ASPIRE.


Instruction: How many exercise tests were done in Sweden over an 18-month period?

Output: 50 000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many exercise tests were done in Sweden over an 18-month period?. ### Response: 50 000.


Instruction: What was the complication rate per 10 000 tests in Sweden?

Output: 18.4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the complication rate per 10 000 tests in Sweden?. ### Response: 18.4.


Instruction: How many of the patients with AS were not reported?

Output: 12

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many of the patients with AS were not reported?. ### Response: 12.


Instruction: How many of the 92 complica-tions occurred in patients with AS?

Output: 12

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many of the 92 complica-tions occurred in patients with AS?. ### Response: 12.


Instruction: How many patients had a decline in blood pressure during exercise, 1 had asystole, and 3 had ventricular tachycardia?

Output: 8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had a decline in blood pressure during exercise, 1 had asystole, and 3 had ventricular tachycardia?. ### Response: 8.


Instruction: Where are the studies that support the recommendations summarized?

Output: Online Data Supplement 5.COR LOE Recommendations1 B-NR1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are the studies that support the recommendations summarized?. ### Response: Online Data Supplement 5.COR LOE Recommendations1 B-NR1.


Instruction: What should be treated according to standard GDMT?

Output: hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be treated according to standard GDMT?. ### Response: hypertension.


Instruction: How is statin therapy indicated in all patients with calcific AS?

Output: primary and secondary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is statin therapy indicated in all patients with calcific AS?. ### Response: primary and secondary.


Instruction: What is the basis for statin treatment in patients with atherosclerosis?

Output: standard risk scores

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the basis for statin treatment in patients with atherosclerosis?. ### Response: standard risk scores.


Instruction: How is GDMT treated?

Output: hypertension and hyperlipidemia according to GDMT is appropriate for patients with AS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is GDMT treated?. ### Response: hypertension and hyperlipidemia according to GDMT is appropriate for patients with AS.


Instruction: What is the basis of standard risk scores?

Output: statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the basis of standard risk scores?. ### Response: statin therapy.


Instruction: What may be considered to reduce the long-term risk of all-cause mortality in patients who have undergone TAVI?

Output: renin–angiotensin system blocker therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered to reduce the long-term risk of all-cause mortality in patients who have undergone TAVI?. ### Response: renin–angiotensin system blocker therapy.


Instruction: What is not indicated for prevention of hemodynamic progression of AS?

Output: statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not indicated for prevention of hemodynamic progression of AS?. ### Response: statin therapy.


Instruction: What is appropriate for patients with AS according to GDMT?

Output: Medical treatment of hypertension and hyperlipidemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is appropriate for patients with AS according to GDMT?. ### Response: Medical treatment of hypertension and hyperlipidemia.


Instruction: ACE inhibitor or ARB treatment may reduce the mortal-ity rate in what patients?

Output: patients who have undergone TAVI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ACE inhibitor or ARB treatment may reduce the mortal-ity rate in what patients?. ### Response: patients who have undergone TAVI.


Instruction: What is common in patients with AS?

Output: Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is common in patients with AS?. ### Response: Hypertension.


Instruction: Hypertension may be a risk factor for what?

Output: AS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hypertension may be a risk factor for what?. ### Response: AS.


Instruction: What adds to total pressure overload on the LV in combination with valve obstruction?

Output: Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What adds to total pressure overload on the LV in combination with valve obstruction?. ### Response: Hypertension.


Instruction: What has not been corroborated in studies of medical therapy?

Output: Concern that antihypertensive medi-cations might result in a decrease in cardiac output

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has not been corroborated in studies of medical therapy?. ### Response: Concern that antihypertensive medi-cations might result in a decrease in cardiac output.


Instruction: What does not result in “fixed” valve obstruction until late in the disease process?

Output: AS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not result in “fixed” valve obstruction until late in the disease process?. ### Response: AS.


Instruction: How many patients were enrolled in the study?

Output: 1616

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were enrolled in the study?. ### Response: 1616.


Instruction: How many patients were downloaded from http://ahajournals.org by on April 28, 2023?

Output: 1616

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were downloaded from http://ahajournals.org by on April 28, 2023?. ### Response: 1616.


Instruction: What is a bioprosthetic valve recommended for?

Output: replacement for whom anticoagulant therapy is contraindicated, cannot be managed appropriately, or is not desired

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a bioprosthetic valve recommended for?. ### Response: replacement for whom anticoagulant therapy is contraindicated, cannot be managed appropriately, or is not desired.


Instruction: What is recommended for patients 50 years of age who do not have a contraindication to anticoagulation and require AVR?

Output: A mechanical valve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for patients 50 years of age who do not have a contraindication to anticoagulation and require AVR?. ### Response: A mechanical valve.


Instruction: What type of prosthesis is more reasonable than a bioprosthetic valve?

Output: mechanical aortic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of prosthesis is more reasonable than a bioprosthetic valve?. ### Response: mechanical aortic.


Instruction: What age range are patients who require AVR and do not have a contraindication to anticoagulation?

Output: 50 to 65 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What age range are patients who require AVR and do not have a contraindication to anticoagulation?. ### Response: 50 to 65 years of age.


Instruction: How old is it reasonable to choose a bioprosthesis over a mechanical valve?

Output: ≥65 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old is it reasonable to choose a bioprosthesis over a mechanical valve?. ### Response: ≥65 years of age.


Instruction: How old are patients 65 years of age who require AVR?

Output: >65 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old are patients 65 years of age who require AVR?. ### Response: >65 years of age.


Instruction: How old is a patient who has an indication for mitral valve replacement?

Output: ≥65 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old is a patient who has an indication for mitral valve replacement?. ### Response: ≥65 years of age.


Instruction: What type of prosthesis is better than a bioprosthetic valve?

Output: mechanical aortic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of prosthesis is better than a bioprosthetic valve?. ### Response: mechanical aortic.


Instruction: How old are patients who are unable to undergo anticoagulation considered to be?

Output: <50 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old are patients who are unable to undergo anticoagulation considered to be?. ### Response: <50 years of age.


Instruction: What is a better choice for patients 65 years of age who require mitral valve replacement and are unable to undergo valve repair?

Output: bioprosthesis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a better choice for patients 65 years of age who require mitral valve replacement and are unable to undergo valve repair?. ### Response: bioprosthesis.


Instruction: What is an alternative to a mechanical valve?

Output: Bioprosthetic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an alternative to a mechanical valve?. ### Response: Bioprosthetic.


Instruction: Patients 50 years old who prefer a bioprosthetic valve may choose what?

Output: Comprehensive Valve Center

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients 50 years old who prefer a bioprosthetic valve may choose what?. ### Response: Comprehensive Valve Center.


Instruction: What is a pulmonic autograft?

Output: Ross procedure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a pulmonic autograft?. ### Response: Ross procedure.


Instruction: What type of valve type is influenced by several factors?

Output: prosthetic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of valve type is influenced by several factors?. ### Response: prosthetic.


Instruction: What is influenced by patient age, values, and preferences?

Output: shared decision-making

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is influenced by patient age, values, and preferences?. ### Response: shared decision-making.


Instruction: What is expected bioprosthetic valve durability?

Output: avoidance of patient–prosthesis mis-match

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is expected bioprosthetic valve durability?. ### Response: avoidance of patient–prosthesis mis-match.


Instruction: The risks associated with long-term VKA an-ticoagulation after a mechanical valve replacement are discussed in what section?

Output: Section 3.2.4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The risks associated with long-term VKA an-ticoagulation after a mechanical valve replacement are discussed in what section?. ### Response: Section 3.2.4.


Instruction: What does Section 3.2.4 regarding valve choice in patients with AS address?

Output: the risks associated with long-term VKA an-ticoagulation after a mechanical valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Section 3.2.4 regarding valve choice in patients with AS address?. ### Response: the risks associated with long-term VKA an-ticoagulation after a mechanical valve replacement.


Instruction: What is the higher rate of bioprosthetic structural valve deterioration observed in younger versus older patients?

Output: significantly

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the higher rate of bioprosthetic structural valve deterioration observed in younger versus older patients?. ### Response: significantly.


Instruction: Why do many younger patients choose to avoid a mechanical prosthesis?

Output: they are unwilling to consider long-term VKA therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why do many younger patients choose to avoid a mechanical prosthesis?. ### Response: they are unwilling to consider long-term VKA therapy.


Instruction: Why are prosthesis patients reluctant to consider long-term VKA therapy?

Output: incon-venience of monitoring, dietary restrictions, medication interactions, and the need to restrict participation in some types of athletic activity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why are prosthesis patients reluctant to consider long-term VKA therapy?. ### Response: incon-venience of monitoring, dietary restrictions, medication interactions, and the need to restrict participation in some types of athletic activity.


Instruction: What is a prudent choice for patients for whom a second surgical procedure would be necessary?

Output: A mechanical valve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a prudent choice for patients for whom a second surgical procedure would be necessary?. ### Response: A mechanical valve.


Instruction: What would be very high risk for patients for whom a second surgical procedure would be?

Output: A mechanical valve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would be very high risk for patients for whom a second surgical procedure would be?. ### Response: A mechanical valve.


Instruction: What has the availability of TAVI changed?

Output: Recommendations for Prosthetic Valve Type

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has the availability of TAVI changed?. ### Response: Recommendations for Prosthetic Valve Type.


Instruction: When were the recommendations downloaded from http://ahajournals.org by?

Output: April 27, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When were the recommendations downloaded from http://ahajournals.org by?. ### Response: April 27, 2023.


Instruction: What does 6.7.6 mean?

Output: Aldosterone Receptor Antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does 6.7.6 mean?. ### Response: Aldosterone Receptor Antagonists.


Instruction: What is 13956.8 mean for Renal Denervation?

Output: Goal BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is 13956.8 mean for Renal Denervation?. ### Response: Goal BP.


Instruction: Where can you find a list of drugs to avoid?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find a list of drugs to avoid?. ### Response: http://ahajournals.org.


Instruction: What does CHEST stand for?

Output: weight-based nomogram

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CHEST stand for?. ### Response: weight-based nomogram.


Instruction: What is the weight-based nomogram?

Output: starting dose, 80 units/kg bolus followed by 18 units/kg/h by infusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the weight-based nomogram?. ### Response: starting dose, 80 units/kg bolus followed by 18 units/kg/h by infusion.


Instruction: How many units of heparin are in a bolus?

Output: 5,000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many units of heparin are in a bolus?. ### Response: 5,000.


Instruction: Who received higher doses within the fi rst 24 h?

Output: Patients whose heparin was weight-adjusted

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who received higher doses within the fi rst 24 h?. ### Response: Patients whose heparin was weight-adjusted.


Instruction: What was significantly lower with the weight-adjusted heparin regimen?

Output: The rate of recurrent thromboem-bolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was significantly lower with the weight-adjusted heparin regimen?. ### Response: The rate of recurrent thromboem-bolism.


Instruction: What is the initial dosing of IV Heparin for VTE either weight-based?

Output: 80 units/kg bolus and 18 units/kg/h infusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the initial dosing of IV Heparin for VTE either weight-based?. ### Response: 80 units/kg bolus and 18 units/kg/h infusion.


Instruction: How many units/kg bolus and 18 units per kg/h infusion?

Output: 80

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many units/kg bolus and 18 units per kg/h infusion?. ### Response: 80.


Instruction: How many units of heparin can be given as a bolus?

Output: 5,000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many units of heparin can be given as a bolus?. ### Response: 5,000.


Instruction: What is the maximum amount of units/d given for treatment of VTE?

Output: 4,000 units

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the maximum amount of units/d given for treatment of VTE?. ### Response: 4,000 units.


Instruction: How many options are there for subcutaneous injection of Heparin?

Output: at least two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many options are there for subcutaneous injection of Heparin?. ### Response: at least two.


Instruction: What is the initial IV bolus of heparin?

Output: /H11601 5,000 units

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the initial IV bolus of heparin?. ### Response: /H11601 5,000 units.


Instruction: How many units/kg twice daily is recommended for acute hepatitis B?

Output: 250

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many units/kg twice daily is recommended for acute hepatitis B?. ### Response: 250.


Instruction: What are the initial subcutaneous doses of the hepatin used for?

Output: 333 units/kg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the initial subcutaneous doses of the hepatin used for?. ### Response: 333 units/kg.


Instruction: What are the doses of heparin for acute coronary syndromes lower than?

Output: those used to treat VTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the doses of heparin for acute coronary syndromes lower than?. ### Response: those used to treat VTE.


Instruction: What do the American College of Cardi-ology recommend?

Output: a heparin bolus of 60 to 70 units/kg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do the American College of Cardi-ology recommend?. ### Response: a heparin bolus of 60 to 70 units/kg.


Instruction: How many units/kg is recommended for a bolus of Heparin followed by an infusion of 12 to 15 units?

Output: 60 to 70

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many units/kg is recommended for a bolus of Heparin followed by an infusion of 12 to 15 units?. ### Response: 60 to 70.


Instruction: How many units of heparin per kg/h is recommended for unstable angina and non-ST-segment elevation myocardial infarction?

Output: 12 to 15

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many units of heparin per kg/h is recommended for unstable angina and non-ST-segment elevation myocardial infarction?. ### Response: 12 to 15.


Instruction: What is recom-mended when given in conjunction with fi brinolytic agents for treatment?

Output: heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recom-mended when given in conjunction with fi brinolytic agents for treatment?. ### Response: heparin.


Instruction: How much is the bolus about?

Output: 60 units/kg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much is the bolus about?. ### Response: 60 units/kg.


Instruction: What is the bolus of ST-segment ele-vation myocardial infarction?

Output: 60 units/kg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the bolus of ST-segment ele-vation myocardial infarction?. ### Response: 60 units/kg.


Instruction: How many units/kg of heparin is given per day?

Output: 250

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many units/kg of heparin is given per day?. ### Response: 250.


Instruction: What is a maximum of 1,000 units/h of infusion?

Output: 12 to 15 units/kg/h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a maximum of 1,000 units/h of infusion?. ### Response: 12 to 15 units/kg/h.


Instruction: What is the risk of bleeding increased by recent surgery, trauma, invasive procedures, or concomitant hemo-static defects?

Output: 61,62

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of bleeding increased by recent surgery, trauma, invasive procedures, or concomitant hemo-static defects?. ### Response: 61,62.


Instruction: What are hemostatic defects?

Output: recurrent thromboem-bolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are hemostatic defects?. ### Response: recurrent thromboem-bolism.


Instruction: What increase the risk of anticoagulant-associated bleeding in hospitalized patients?

Output: increasing number of comorbidities, age  .  60 y, suprathera-peutic clotting times, and worsening hepatic dysfunc-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What increase the risk of anticoagulant-associated bleeding in hospitalized patients?. ### Response: increasing number of comorbidities, age  .  60 y, suprathera-peutic clotting times, and worsening hepatic dysfunc-tion.


Instruction: How long does suprathera-peutic clotting times and worsening hepatic dysfunction take?

Output: 60 y

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does suprathera-peutic clotting times and worsening hepatic dysfunction take?. ### Response: 60 y.


Instruction: What is a relationship between the dose of heparin administered and its effi -cacy 33,47,65 and safety?

Output: Investigators have reported

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a relationship between the dose of heparin administered and its effi -cacy 33,47,65 and safety?. ### Response: Investigators have reported.


Instruction: What is it stan-dard practice to monitor and adjust the dose based on the results of a patient's anticoagulant response?

Output: coagulation tests

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is it stan-dard practice to monitor and adjust the dose based on the results of a patient's anticoagulant response?. ### Response: coagulation tests.


Instruction: What is the evidence for adjusting the dose of heparin to main-tain a “therapeutic range”?

Output: weak

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the evidence for adjusting the dose of heparin to main-tain a “therapeutic range”?. ### Response: weak.


Instruction: What is based on a post hoc subgroup analysis of a descriptive study?

Output: The evidence for adjusting the dose of heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is based on a post hoc subgroup analysis of a descriptive study?. ### Response: The evidence for adjusting the dose of heparin.


Instruction: What is particularly pernicious in the heart?

Output: increased oxygen demand

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is particularly pernicious in the heart?. ### Response: increased oxygen demand.


Instruction: The heart is an aerobic organ that can develop only a small what?

Output: oxygen debt

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The heart is an aerobic organ that can develop only a small what?. ### Response: oxygen debt.


Instruction: What is almost maximal even at rest?

Output: oxygen extraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is almost maximal even at rest?. ### Response: oxygen extraction.


Instruction: What can increase little with increased demand?

Output: oxygen extraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can increase little with increased demand?. ### Response: oxygen extraction.


Instruction: What does lower BP improve in hypertensive patients?

Output: cardiovascular outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does lower BP improve in hypertensive patients?. ### Response: cardiovascular outcomes.


Instruction: How long is coronary perfusion maintained above the lower autoregulatory limit for coronary blood flow?

Output: as long

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is coronary perfusion maintained above the lower autoregulatory limit for coronary blood flow?. ### Response: as long.


Instruction: What could reduce coronary blood flow?

Output: any further reduction of DBP to levels below the lower autoregu-latory limit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could reduce coronary blood flow?. ### Response: any further reduction of DBP to levels below the lower autoregu-latory limit.


Instruction: What could the reduction of DBP to levels below the lower autoregu-latory limit result in?

Output: reduce coronary blood flow

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could the reduction of DBP to levels below the lower autoregu-latory limit result in?. ### Response: reduce coronary blood flow.


Instruction: When DBP is lowered beyond this limit, what could happen?

Output: an upturn in the incidence of coronary events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When DBP is lowered beyond this limit, what could happen?. ### Response: an upturn in the incidence of coronary events.


Instruction: When is consumption increased such as during exercise?

Output: myocar -dial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is consumption increased such as during exercise?. ### Response: myocar -dial.


Instruction: What would the relationship between DBP and coronary events show if this were true?

Output: a J-shaped curve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would the relationship between DBP and coronary events show if this were true?. ### Response: a J-shaped curve.


Instruction: What is the lower limit of autoregulation in the human coronary circu-lation, in healthy individuals, or in patients with hypertension and CAD?

Output: DBP level

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the lower limit of autoregulation in the human coronary circu-lation, in healthy individuals, or in patients with hypertension and CAD?. ### Response: DBP level.


Instruction: What is reasonable to assume that a rapid reduction in DBP to very low levels may be more hazardous?

Output: patients with combined hypertension and CAD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable to assume that a rapid reduction in DBP to very low levels may be more hazardous?. ### Response: patients with combined hypertension and CAD.


Instruction: What is hazardous in patients with combined hypertension and CAD?

Output: a rapid reduction in DBP to very low levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hazardous in patients with combined hypertension and CAD?. ### Response: a rapid reduction in DBP to very low levels.


Instruction: What must we rely on to try to resolve this issue?

Output: clinical studies with surrogate end points and the few relevant clinical trials with outcomes data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must we rely on to try to resolve this issue?. ### Response: clinical studies with surrogate end points and the few relevant clinical trials with outcomes data.


Instruction: How many patients with CAD completed the intravascular ultrasound substudy of the CAMELOT trial?

Output: 274

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with CAD completed the intravascular ultrasound substudy of the CAMELOT trial?. ### Response: 274.


Instruction: How many subjects with a normal BP were found to have a lower BP?

Output: 274

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many subjects with a normal BP were found to have a lower BP?. ### Response: 274.


Instruction: What did the CAMELOT trial132 show?

Output: those subjects with a normal BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the CAMELOT trial132 show?. ### Response: those subjects with a normal BP.


Instruction: What was the mean decrease in coronary atheroma volume?

Output: 4.6 mm3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean decrease in coronary atheroma volume?. ### Response: 4.6 mm3.


Instruction: How many subjects had a normal BP according to the seventh report?

Output: 274

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many subjects had a normal BP according to the seventh report?. ### Response: 274.


Instruction: Pre-hypertensive subjects had no signifi-cant change in what?

Output: coronary atheroma volume

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Pre-hypertensive subjects had no signifi-cant change in what?. ### Response: coronary atheroma volume.


Instruction: What did the authors conclude about the optimal BP goal in patients with CAD?

Output: substantially lower than the <140/90 mm Hg level

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the authors conclude about the optimal BP goal in patients with CAD?. ### Response: substantially lower than the <140/90 mm Hg level.


Instruction: What may be substantially lower than the 140/90 mm Hg level in patients with CAD?

Output: the optimal BP goal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be substantially lower than the 140/90 mm Hg level in patients with CAD?. ### Response: the optimal BP goal.


Instruction: Why can the results of CAMELOT be taken only as hypothesis generating?

Output: because the effect of achieved BP on ath-eroma volume was not a prespecified outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why can the results of CAMELOT be taken only as hypothesis generating?. ### Response: because the effect of achieved BP on ath-eroma volume was not a prespecified outcome.


Instruction: What was not a prespecified outcome?

Output: the effect of achieved BP on ath-eroma volume

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not a prespecified outcome?. ### Response: the effect of achieved BP on ath-eroma volume.


Instruction: What is a potential confounding effect of the post-hoc analysis?

Output: residual confound-ing effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a potential confounding effect of the post-hoc analysis?. ### Response: residual confound-ing effects.


Instruction: Why are the individuals in the higher BP cohort more likely to have been assigned to the placebo arm of the study?

Output: older

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why are the individuals in the higher BP cohort more likely to have been assigned to the placebo arm of the study?. ### Response: older.


Instruction: What is the name of the arm of the study that was not treated with amlodipine or enalapril?

Output: placebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the arm of the study that was not treated with amlodipine or enalapril?. ### Response: placebo.


Instruction: What would be clinically important if coronary autoregulation were?

Output: show a J-shaped curve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would be clinically important if coronary autoregulation were?. ### Response: show a J-shaped curve.


Instruction: What is COSSACS?

Output: a prospective, ran-domised, open, blinded-endpoint trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is COSSACS?. ### Response: a prospective, ran-domised, open, blinded-endpoint trial.


Instruction: What is the name of the prospective, ran-domised, open, blinded-endpoint trial?

Output: COSSACS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective, ran-domised, open, blinded-endpoint trial?. ### Response: COSSACS.


Instruction: What effect does immediate blood pressure reduc-tion have on death and major disability in patients with acute ischemic stroke?

Output: brain injury and poor stroke outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What effect does immediate blood pressure reduc-tion have on death and major disability in patients with acute ischemic stroke?. ### Response: brain injury and poor stroke outcome.


Instruction: When did the CATIS randomized clinical trial begin?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the CATIS randomized clinical trial begin?. ### Response: 2014.


Instruction: What does early blood pressure lowering do to early and long-term outcomes after acute stroke?

Output: brain injury and poor stroke outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does early blood pressure lowering do to early and long-term outcomes after acute stroke?. ### Response: brain injury and poor stroke outcome.


Instruction: What does blood pressure reduction in the acute phase of an ischemic stroke not improve?

Output: short- or long-term dependency or mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does blood pressure reduction in the acute phase of an ischemic stroke not improve?. ### Response: short- or long-term dependency or mortality.


Instruction: What does stroke do to short- or long-term dependency or mortality?

Output: does not improve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does stroke do to short- or long-term dependency or mortality?. ### Response: does not improve.


Instruction: What is the name of the angiotensin-recep-tor blocker?

Output: candesartan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the angiotensin-recep-tor blocker?. ### Response: candesartan.


Instruction: What is the name of the double-blind trial of the angiotensin-recep-tor blocker candesartan for treatment of acute stroke?

Output: SCAST

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the double-blind trial of the angiotensin-recep-tor blocker candesartan for treatment of acute stroke?. ### Response: SCAST.


Instruction: What is SCAST?

Output: angiotensin-recep-tor blocker candesartan for treatment of acute stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SCAST?. ### Response: angiotensin-recep-tor blocker candesartan for treatment of acute stroke.


Instruction: How many adult patients with stroke presented to the ED in 2011?

Output: 563 704

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many adult patients with stroke presented to the ED in 2011?. ### Response: 563 704.


Instruction: How many adults with stroke present to the ED in the United States?

Output: 563 704

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many adults with stroke present to the ED in the United States?. ### Response: 563 704.


Instruction: What is the name of the study that examined blood pressure and clinical outcomes in the International Stroke Trial?

Output: Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined blood pressure and clinical outcomes in the International Stroke Trial?. ### Response: Stroke.


Instruction: What is blood pressure decrease during the acute phase of ischemic stroke associated with?

Output: brain injury and poor stroke outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is blood pressure decrease during the acute phase of ischemic stroke associated with?. ### Response: brain injury and poor stroke outcome.


Instruction: What is the U-shaped relation-ship between mortality and admission blood pressure in patients with acute stroke?

Output: S9.4.2-14

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the U-shaped relation-ship between mortality and admission blood pressure in patients with acute stroke?. ### Response: S9.4.2-14.


Instruction: What is mortality and admission blood pressure in patients with acute stroke?

Output: U-shaped relation-ship

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is mortality and admission blood pressure in patients with acute stroke?. ### Response: U-shaped relation-ship.


Instruction: What is a guideline for healthcare professionals from the American Heart Association/American Stroke Association?

Output: Guidelines for the early management of patients with acute ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a guideline for healthcare professionals from the American Heart Association/American Stroke Association?. ### Response: Guidelines for the early management of patients with acute ischemic stroke.


Instruction: What is the name of the study conducted by the American Heart Association/American Stroke Association?

Output: Continue or Stop Post-Stroke Antihypertensives Collaborative Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study conducted by the American Heart Association/American Stroke Association?. ### Response: Continue or Stop Post-Stroke Antihypertensives Collaborative Study.


Instruction: What is secondary stroke prevention S9.4.3-1?

Output: Blood pressure reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is secondary stroke prevention S9.4.3-1?. ### Response: Blood pressure reduction.


Instruction: How is blood pressure reduced for the secondary prevention of stroke?

Output: a Chinese trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is blood pressure reduced for the secondary prevention of stroke?. ### Response: a Chinese trial.


Instruction: What is the name of the systematic review and meta-analysis of blood pressure lowering treatment for pre-venting stroke recurrence?

Output: ko MT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta-analysis of blood pressure lowering treatment for pre-venting stroke recurrence?. ### Response: ko MT.


Instruction: How many indi-viduals with previous stroke or transient ischaemic attack were enrolled in a randomised trial of a blood pressure-lowering regimen?

Output: 6 105

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many indi-viduals with previous stroke or transient ischaemic attack were enrolled in a randomised trial of a blood pressure-lowering regimen?. ### Response: 6 105.


Instruction: What is myocardial infarction a complication of in acute stroke?

Output: vascular death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is myocardial infarction a complication of in acute stroke?. ### Response: vascular death.


Instruction: What is the Austrian Stroke Unit Registry?

Output: Myocardial infarction as a complication in acute stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Austrian Stroke Unit Registry?. ### Response: Myocardial infarction as a complication in acute stroke.


Instruction: What is the name of the systematic review and meta-analysis that evaluated the risk of myocardial infarction and vascular death after transient ischemic attack and stroke?

Output: Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta-analysis that evaluated the risk of myocardial infarction and vascular death after transient ischemic attack and stroke?. ### Response: Stroke.


Instruction: What year did Stroke. 2005:36:2748–2755. doi: 10.1161/01.STR.0000190118.02275.33?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Stroke. 2005:36:2748–2755. doi: 10.1161/01.STR.0000190118.02275.33?. ### Response: 2005.


Instruction: What is the clinical importance of cardiac troponin release and cardiac abnormali-ties in patients with supratentorial cerebral hemorrhages?

Output: 178

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the clinical importance of cardiac troponin release and cardiac abnormali-ties in patients with supratentorial cerebral hemorrhages?. ### Response: 178.


Instruction: When did Mayo Clin Proc. 2006:81:192–196. doi: 10.4065/81.2.192?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Mayo Clin Proc. 2006:81:192–196. doi: 10.4065/81.2.192?. ### Response: 2006.


Instruction: What type of edema in patients with nontraumatic intracerebral hem-orrhage is a predictor of outcome?

Output: Neurogenic pulmonary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of edema in patients with nontraumatic intracerebral hem-orrhage is a predictor of outcome?. ### Response: Neurogenic pulmonary.


Instruction: What is the name of the study that investigated neurogenic pulmonary edma in nontraumatic hem orrhages?

Output: Anesth Analg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated neurogenic pulmonary edma in nontraumatic hem orrhages?. ### Response: Anesth Analg.


Instruction: What is acute respira-tory distress syndrome after spontaneous intracerebral hemorrhage?

Output: Low-tidal-volume ventilation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is acute respira-tory distress syndrome after spontaneous intracerebral hemorrhage?. ### Response: Low-tidal-volume ventilation.


Instruction: What is the name of the study that investigated low-tidal-volume ventilation?

Output: Malhotra A

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated low-tidal-volume ventilation?. ### Response: Malhotra A.


Instruction: What is the name of the study that investigated low-tidal-volume ventilation in the acute respiratory dis-tress syndrome?

Output: Malhotra A

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated low-tidal-volume ventilation in the acute respiratory dis-tress syndrome?. ### Response: Malhotra A.


Instruction: What year was the N Engl J Med 357:1113-1120?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the N Engl J Med 357:1113-1120?. ### Response: 2007.


Instruction: What does CT angiography for intracerebral hemorrhage do not increase risk of?

Output: acute nephropathy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CT angiography for intracerebral hemorrhage do not increase risk of?. ### Response: acute nephropathy.


Instruction: What is the doi: 10.1161/STROKEAHA.108.546127?

Output: Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the doi: 10.1161/STROKEAHA.108.546127?. ### Response: Stroke.


Instruction: How does continuous monitoring of ICP and CPP follow ICH?

Output: relationship to clinical, radiological and surgical parameters

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does continuous monitoring of ICP and CPP follow ICH?. ### Response: relationship to clinical, radiological and surgical parameters.


Instruction: What is CPP following ICH and its relationship to clinical, radiological and surgical parameters?

Output: Continuous monitoring of ICP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CPP following ICH and its relationship to clinical, radiological and surgical parameters?. ### Response: Continuous monitoring of ICP.


Instruction: Acta Neurochir Suppl. 2000;76:463-466.

Output: 183

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Acta Neurochir Suppl. 2000;76:463-466.. ### Response: 183.


Instruction: What is the frequency of sustained intracranial pressure elevation during treatment of severe intraventricular hemorrhage?

Output: 184

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the frequency of sustained intracranial pressure elevation during treatment of severe intraventricular hemorrhage?. ### Response: 184.


Instruction: What is intracranial pressure elevation during treatment of?

Output: severe intraventricular hemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is intracranial pressure elevation during treatment of?. ### Response: severe intraventricular hemorrhage.


Instruction: What is the name of the 2009 issue that dealt with intraventricular hemorrhage?

Output: Cerebrovasc Dis.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2009 issue that dealt with intraventricular hemorrhage?. ### Response: Cerebrovasc Dis..


Instruction: When did Crit Care Med issue 40:1601-1608?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Crit Care Med issue 40:1601-1608?. ### Response: 2012.


Instruction: Crit Care Med. 2012;40:1601–1608. doi: 10.1097/CCM.0b013e318241e380.

Output: treatment of severe intraventricular hemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Crit Care Med. 2012;40:1601–1608. doi: 10.1097/CCM.0b013e318241e380.. ### Response: treatment of severe intraventricular hemorrhage.


Instruction: Kamel H, Hemphill JC 3rd. Characteristics and sequelae of intra-cranial hypertension after intracerebral hemorrhage.

Output: 185

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Kamel H, Hemphill JC 3rd. Characteristics and sequelae of intra-cranial hypertension after intracerebral hemorrhage.. ### Response: 185.


Instruction: What enzyme is involved in vascular disease?

Output: angiotensin-converting enzyme

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What enzyme is involved in vascular disease?. ### Response: angiotensin-converting enzyme.


Instruction: What is the main mediator of pulmonaryhypertension and pulmonary vascular diseases?

Output: endothelin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the main mediator of pulmonaryhypertension and pulmonary vascular diseases?. ### Response: endothelin.


Instruction: Endothelin has been identified as what?

Output: the major mediator of pulmonaryhypertension and pulmonary vascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Endothelin has been identified as what?. ### Response: the major mediator of pulmonaryhypertension and pulmonary vascular disease.


Instruction: What is a potential target for future genetherapy?

Output: bloodvessels are protected from injury by estrogens

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a potential target for future genetherapy?. ### Response: bloodvessels are protected from injury by estrogens.


Instruction: Who has made many significant contributions tovascular biology and hypertension research?

Output: Dr Perkovic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who has made many significant contributions tovascular biology and hypertension research?. ### Response: Dr Perkovic.


Instruction: Who is the ExecutiveDirector of George Clinical at The George Institute forInternational Health?

Output: TakedaVlado Perkovic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the ExecutiveDirector of George Clinical at The George Institute forInternational Health?. ### Response: TakedaVlado Perkovic.


Instruction: What is the staff specialist in Nephrology and Hypertension at the Royal North Shore?

Output: TakedaVlado Perkovic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the staff specialist in Nephrology and Hypertension at the Royal North Shore?. ### Response: TakedaVlado Perkovic.


Instruction: Where did Dr Perkovic receive his medical degree?

Output: University of Melbourne

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where did Dr Perkovic receive his medical degree?. ### Response: University of Melbourne.


Instruction: Where did he complete his training in nephrology and general medicine?

Output: RoyalMelbourne Hospital

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where did he complete his training in nephrology and general medicine?. ### Response: RoyalMelbourne Hospital.


Instruction: How many publications does Dr Perkovic have?

Output: over 75

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many publications does Dr Perkovic have?. ### Response: over 75.


Instruction: What is the name of the group for Australasians with Renal Impairment?

Output: Cardiovascular Guideline Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group for Australasians with Renal Impairment?. ### Response: Cardiovascular Guideline Group.


Instruction: How many publications does Dr. Perkovic review?

Output: over 75

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many publications does Dr. Perkovic review?. ### Response: over 75.


Instruction: Who is Dr. Isaac Saad Rodrigues a full Professor of?

Output: Nephrology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Dr. Isaac Saad Rodrigues a full Professor of?. ### Response: Nephrology.


Instruction: Who is a full Professor of Nephrology at the Faculdade de Cie ncias Me dicas e da Sau de –Pontif cia Universidade Cato lica de Sa o Paulo – (PUC-SP)?

Output: Cibele Isaac Saad Rodrigues

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a full Professor of Nephrology at the Faculdade de Cie ncias Me dicas e da Sau de –Pontif cia Universidade Cato lica de Sa o Paulo – (PUC-SP)?. ### Response: Cibele Isaac Saad Rodrigues.


Instruction: Where did she receive her Master's and Doctorate degrees in Nephrology?

Output: FederalUniversity of Sa ˜o Paulo, Brazil

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where did she receive her Master's and Doctorate degrees in Nephrology?. ### Response: FederalUniversity of Sa ˜o Paulo, Brazil.


Instruction: Where is Santa Lucinda Hospital located?

Output: Sorocaba– Sa ˜oPaulo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Santa Lucinda Hospital located?. ### Response: Sorocaba– Sa ˜oPaulo.


Instruction: What is the name of the department that she coordinates?

Output: Hypertension Department of theBrazilian Society of Nephrology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the department that she coordinates?. ### Response: Hypertension Department of theBrazilian Society of Nephrology.


Instruction: Who is a member of the ScientificCouncil of the Brazilian Society of Hypertension?

Output: idade Cato ´lica de Sa ˜o Paulo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a member of the ScientificCouncil of the Brazilian Society of Hypertension?. ### Response: idade Cato ´lica de Sa ˜o Paulo.


Instruction: From 2001 to 2009, who was the dean of the Centro de Cie ncias Me dicas eBiolo gicas?

Output: idade Cato ´lica de Sa ˜o Paulo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: From 2001 to 2009, who was the dean of the Centro de Cie ncias Me dicas eBiolo gicas?. ### Response: idade Cato ´lica de Sa ˜o Paulo.


Instruction: What was her primary research?

Output: Kidney International Supplements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was her primary research?. ### Response: Kidney International Supplements.


Instruction: What is Lucinda Hospital's primary research?

Output: Kidney International Supplements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Lucinda Hospital's primary research?. ### Response: Kidney International Supplements.


Instruction: What year did Fukushima K, Javadi MS, Higuchi T, et al. use quantification of global myocardial flowreserve in patients referred for clinical 82Rb PET perfusion imaging?

Output: 2004.184

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Fukushima K, Javadi MS, Higuchi T, et al. use quantification of global myocardial flowreserve in patients referred for clinical 82Rb PET perfusion imaging?. ### Response: 2004.184.


Instruction: What is the difference between (82)Rb PET and (13)N-ammonia PET?

Output: Reproducibility and accuracy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between (82)Rb PET and (13)N-ammonia PET?. ### Response: Reproducibility and accuracy.


Instruction: When was the J Nucl Med published?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Nucl Med published?. ### Response: 2011.


Instruction: What was the Incremental Diagnostic Value of Regional Myocardial Blood Flow Quantification Over Relative Perfusion Imaging?

Output: :1062–71.186

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the Incremental Diagnostic Value of Regional Myocardial Blood Flow Quantification Over Relative Perfusion Imaging?. ### Response: :1062–71.186.


Instruction: What is Rubidium-82 PET?

Output: Incremental Diagnostic Valueof Regional Myocardial Blood Flow Quantification Over RelativePerfusion Imaging With Generator-Produced

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Rubidium-82 PET?. ### Response: Incremental Diagnostic Valueof Regional Myocardial Blood Flow Quantification Over RelativePerfusion Imaging With Generator-Produced.


Instruction: What is SPECT myocardial perfusionimaging in morbidly obese patients: image quality, hemodyn amicresponse to pharmacologic stress and diagnostic value?

Output: prognostic value

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SPECT myocardial perfusionimaging in morbidly obese patients: image quality, hemodyn amicresponse to pharmacologic stress and diagnostic value?. ### Response: prognostic value.


Instruction: What does gatedTc-99m sestamibi stress myocardial perfusion SPECT with combinedsupine and prone acquisitions detect in obese and nonobese patients?

Output: coronary artery disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does gatedTc-99m sestamibi stress myocardial perfusion SPECT with combinedsupine and prone acquisitions detect in obese and nonobese patients?. ### Response: coronary artery disease.


Instruction: When did J Nucl Cardiol. 2006;13:191–201.189?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J Nucl Cardiol. 2006;13:191–201.189?. ### Response: 2006.


Instruction: What improves detection on ofcoronary artery disease?

Output: Combined quantita tivesupine-prone myocardial perfusion SPECT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What improves detection on ofcoronary artery disease?. ### Response: Combined quantita tivesupine-prone myocardial perfusion SPECT.


Instruction: What improves detection of ofcoronary artery disease and normalcy rates in women?

Output: Combined quantita tivesupine-prone myocardial perfusion SPECT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What improves detection of ofcoronary artery disease and normalcy rates in women?. ### Response: Combined quantita tivesupine-prone myocardial perfusion SPECT.


Instruction: What is improved outcomeprediction by SPECT myocardial perfusion imaging?

Output: CT atten-uation correction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is improved outcomeprediction by SPECT myocardial perfusion imaging?. ### Response: CT atten-uation correction.


Instruction: What type of imaging is used in the detection of coronary artery disease?

Output: positron emission tomography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of imaging is used in the detection of coronary artery disease?. ### Response: positron emission tomography.


Instruction: What is the diagnostic accuracy ofrubidium-82 myocardial perfusion imaging?

Output: Incremental Diagnostic Value

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the diagnostic accuracy ofrubidium-82 myocardial perfusion imaging?. ### Response: Incremental Diagnostic Value.


Instruction: When was the J Am Coll Cardiol 49:1052–8.192?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol 49:1052–8.192?. ### Response: 2007.


Instruction: What is a meta-analysis of positron emission tomography in the detection of coronaryartery disease?

Output: Diagnostic per-formance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a meta-analysis of positron emission tomography in the detection of coronaryartery disease?. ### Response: Diagnostic per-formance.


Instruction: What is the diagnostic accuracy ofrest/stress ECG-gated Rb-82?

Output: comparisonwith ECG-gated Tc-99m sestamibi SPECT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the diagnostic accuracy ofrest/stress ECG-gated Rb-82?. ### Response: comparisonwith ECG-gated Tc-99m sestamibi SPECT.


Instruction: What is the negative predictive value of normaladenosine-stress cardiac MRI in the assessment of coronary arterydisease and correlation with semiquantitative perfusion a nalysis?

Output: Negative predictive value of normaladenosine-stress cardiac MRI in the assessment of coronary arterydisease and correlation with semiquantitative perfusion a nalysis.J Magn Reson Imaging. 2010;32:615–21.195

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the negative predictive value of normaladenosine-stress cardiac MRI in the assessment of coronary arterydisease and correlation with semiquantitative perfusion a nalysis?. ### Response: Negative predictive value of normaladenosine-stress cardiac MRI in the assessment of coronary arterydisease and correlation with semiquantitative perfusion a nalysis.J Magn Reson Imaging. 2010;32:615–21.195.


Instruction: What is a noninvasive fractional flow reserve?

Output: Diagnosis of ischemia-causingcoronary stenoses by noninvasive fractional flow reserve computedfrom coronary computed tomographic angiograms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a noninvasive fractional flow reserve?. ### Response: Diagnosis of ischemia-causingcoronary stenoses by noninvasive fractional flow reserve computedfrom coronary computed tomographic angiograms.


Instruction: What does DISCOVER-FLOW stand for?

Output: Diagnosis of Ischemia-Causing Stenoses Obtained Via Noninvasive Fractional Flow Reserve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does DISCOVER-FLOW stand for?. ### Response: Diagnosis of Ischemia-Causing Stenoses Obtained Via Noninvasive Fractional Flow Reserve.


Instruction: What is the name of the multicenter study?

Output: DISCOVER-FLOW

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multicenter study?. ### Response: DISCOVER-FLOW.


Instruction: When was the J Am Coll Cardiol 58:1989-97.196?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol 58:1989-97.196?. ### Response: 2011.