Instruction: How old is the general population of the Wolff-Parkinson-White syndrome?

Output: younger than 50 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old is the general population of the Wolff-Parkinson-White syndrome?. ### Response: younger than 50 years of age.


Instruction: In what year did BMJ issue 345:e7769?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did BMJ issue 345:e7769?. ### Response: 2012.


Instruction: What is the name of the disease that causes supraventricular tachycardia?

Output: paroxysmal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease that causes supraventricular tachycardia?. ### Response: paroxysmal.


Instruction: When was the BMJ 345:e7769 published?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the BMJ 345:e7769 published?. ### Response: 2012.


Instruction: What are the names of the two factors that influence the mechanism of supraventricular Tactical Disease?

Output: Combined evalu-ation of bedside clinical variables

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the two factors that influence the mechanism of supraventricular Tactical Disease?. ### Response: Combined evalu-ation of bedside clinical variables.


Instruction: Where is Campbell RW from?

Output: 50

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Campbell RW from?. ### Response: 50.


Instruction: What is a frequent threat?

Output: Supraventricular tachycardia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a frequent threat?. ### Response: Supraventricular tachycardia.


Instruction: What is the name of the drug used in the emergency management of paroxysmal supraventricular tachycardia?

Output: Intravenous adenosine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used in the emergency management of paroxysmal supraventricular tachycardia?. ### Response: Intravenous adenosine.


Instruction: When was the Ann Emerg Med. 1991;20:717–21?

Output: 1991

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Ann Emerg Med. 1991;20:717–21?. ### Response: 1991.


Instruction: What are the ages of tachycardia onset in patients with atrioventricular nodal reentrant and accessory pathway-mediated?

Output: 53

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the ages of tachycardia onset in patients with atrioventricular nodal reentrant and accessory pathway-mediated?. ### Response: 53.


Instruction: What is A VRT?

Output: atrioventricular reentry tachycardia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is A VRT?. ### Response: atrioventricular reentry tachycardia.


Instruction: How does A VNRT affect children's cognitive and emotional development?

Output: atrioventricular nodal reentry tachycardia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does A VNRT affect children's cognitive and emotional development?. ### Response: atrioventricular nodal reentry tachycardia.


Instruction: What does tachycardia in children affect?

Output: cognitive and emotional development

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does tachycardia in children affect?. ### Response: cognitive and emotional development.


Instruction: What is the name of the condition that affects children's cognitive and emotional development?

Output: atrioventricular reentry tachycardia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the condition that affects children's cognitive and emotional development?. ### Response: atrioventricular reentry tachycardia.


Instruction: When was the last time a child was diagnosed with A VNRT?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last time a child was diagnosed with A VNRT?. ### Response: 2013.


Instruction: In what year did the J Am Coll Cardiol issue 53:2353–8?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did the J Am Coll Cardiol issue 53:2353–8?. ### Response: 2009.


Instruction: What is the cause of tachycardias in patients without pre-excitation?

Output: paroxysmal atrioventricular reciprocating

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cause of tachycardias in patients without pre-excitation?. ### Response: paroxysmal atrioventricular reciprocating.


Instruction: What was the J Am Coll Cardiol. 2009;53:2353–8?

Output: Combined evalu-ation of bedside clinical variables and the electrocardiogram for the differential diagnosis of paroxysmal atrioventricular reciprocating tachycardias in patients without pre-excitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the J Am Coll Cardiol. 2009;53:2353–8?. ### Response: Combined evalu-ation of bedside clinical variables and the electrocardiogram for the differential diagnosis of paroxysmal atrioventricular reciprocating tachycardias in patients without pre-excitation.


Instruction: What can be useful in patients with short QT syndrome and VT/VF storm?

Output: isoproterenol infusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be useful in patients with short QT syndrome and VT/VF storm?. ### Response: isoproterenol infusion.


Instruction: What isoproterenol infusion can be effective?

Output: restoring/maintaining sinus rhythm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What isoproterenol infusion can be effective?. ### Response: restoring/maintaining sinus rhythm.


Instruction: Genetic testing may be considered to facilitate screening of what?

Output: first-degree relatives

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Genetic testing may be considered to facilitate screening of what?. ### Response: first-degree relatives.


Instruction: What is the prevalence of short QTc 340 ms in persons 21 years of age?

Output: 285 ms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the prevalence of short QTc 340 ms in persons 21 years of age?. ### Response: 285 ms.


Instruction: What is more common in males?

Output: short QTc

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more common in males?. ### Response: short QTc.


Instruction: What type of patient warrants monitoring and follow-up without prophylactic medication treatment?

Output: asymp-tomatic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of patient warrants monitoring and follow-up without prophylactic medication treatment?. ### Response: asymp-tomatic.


Instruction: Patients with cardiac arrest in the setting of short QT syndrome are known to be at increased risk for recurrent cardiac arrest?

Output: S7.9.1.5-1,S7.9.1.5-22

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with cardiac arrest in the setting of short QT syndrome are known to be at increased risk for recurrent cardiac arrest?. ### Response: S7.9.1.5-1,S7.9.1.5-22.


Instruction: Patients with short QT and implanted ICDs have experienced what during short-term follow-up?

Output: appropriate ICD therapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with short QT and implanted ICDs have experienced what during short-term follow-up?. ### Response: appropriate ICD therapies.


Instruction: Therapy with what may reduce the number of ICD shocks?

Output: quinidine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Therapy with what may reduce the number of ICD shocks?. ### Response: quinidine.


Instruction: Markly shortened QTc values 300 ms are associated with what?

Output: increased risk of SCD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Markly shortened QTc values 300 ms are associated with what?. ### Response: increased risk of SCD.


Instruction: What was the median QTc in young persons?

Output: 285 ms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the median QTc in young persons?. ### Response: 285 ms.


Instruction: What is a clinical score including?

Output: QTc duration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a clinical score including?. ### Response: QTc duration.


Instruction: A family history of autopsy-negative SCD or sudden infant death syndrome has been proposed to what?

Output: identify patients at increased  risk for SCD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A family history of autopsy-negative SCD or sudden infant death syndrome has been proposed to what?. ### Response: identify patients at increased  risk for SCD.


Instruction: What has been proposed to identify patients at increased risk for SCD?

Output: positive genotype results

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been proposed to identify patients at increased risk for SCD?. ### Response: positive genotype results.


Instruction: What results in lengthening of the QTc?

Output: Treatment with quini-dine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What results in lengthening of the QTc?. ### Response: Treatment with quini-dine.


Instruction: Treatment with quini-dine may be an alternative to what?

Output: ICD implantation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Treatment with quini-dine may be an alternative to what?. ### Response: ICD implantation.


Instruction: What can be effective in setting of electrical storm with refractory VF and short QT syndrome?

Output: infusion of isoproterenol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be effective in setting of electrical storm with refractory VF and short QT syndrome?. ### Response: infusion of isoproterenol.


Instruction: What can infusion of isoproterenol restore/maintain?

Output: sinus rhythm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can infusion of isoproterenol restore/maintain?. ### Response: sinus rhythm.


Instruction: Pathogenic mutations in potassium channels have been identified in approximately 10% of what?

Output: Recommendations for Short QT Syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Pathogenic mutations in potassium channels have been identified in approximately 10% of what?. ### Response: Recommendations for Short QT Syndrome.


Instruction: What is REVascularisation for Ischaemic VEntricular Dysfunction?

Output: REVIVED

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is REVascularisation for Ischaemic VEntricular Dysfunction?. ### Response: REVIVED.


Instruction: What is the name of the NIHR HTA CET study?

Output: King's College London

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the NIHR HTA CET study?. ### Response: King's College London.


Instruction: Where can you find REVived?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find REVived?. ### Response: http://revived.lshtm.ac.uk.


Instruction: How is iron deficiency diagnosed in chronic heart failure?

Output: an international pooled analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is iron deficiency diagnosed in chronic heart failure?. ### Response: an international pooled analysis.


Instruction: What is iron deficiency in chronic heart failure an international pooled analysis of?

Output: American Heart Journal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is iron deficiency in chronic heart failure an international pooled analysis of?. ### Response: American Heart Journal.


Instruction: What is N-terminal B-type natriuretic peptide?

Output: NT -proBNP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is N-terminal B-type natriuretic peptide?. ### Response: NT -proBNP.


Instruction: Knebel F, Eddicks S, Schimke I, Bierbaum M, Schattke S, Beling M et al.

Output: 177

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Knebel F, Eddicks S, Schimke I, Bierbaum M, Schattke S, Beling M et al.. ### Response: 177.


Instruction: What is N -terminal B -type natriuretic peptide?

Output: NT -proBNP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is N -terminal B -type natriuretic peptide?. ### Response: NT -proBNP.


Instruction: What is NT -proBNP?

Output: N -terminal B -type natriuretic peptide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NT -proBNP?. ### Response: N -terminal B -type natriuretic peptide.


Instruction: What may not explain poorer outcomes in patients with Staphylococcus aureus bacte-remia and high vancomycin minimum inhibitory concentrations?

Output: Antibiotic choice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may not explain poorer outcomes in patients with Staphylococcus aureus bacte-remia and high vancomycin minimum inhibitory concentrations?. ### Response: Antibiotic choice.


Instruction: What is the doi: 10.1093/infdis/jir270?

Output: 142

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the doi: 10.1093/infdis/jir270?. ### Response: 142.


Instruction: Who is the Hospital Clinic Endocarditis Study Group?

Output: Lacasa X, Marco F, Gumá JR, Quaglio G, Claramonte X, Moreno A, Mestres CA, Mauri E, Azqueta M, Benito N, García-de la María C, Almela M, Jiménez-Expósito MJ, Sued O, De Lazzari E, Gatell JM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Hospital Clinic Endocarditis Study Group?. ### Response: Lacasa X, Marco F, Gumá JR, Quaglio G, Claramonte X, Moreno A, Mestres CA, Mauri E, Azqueta M, Benito N, García-de la María C, Almela M, Jiménez-Expósito MJ, Sued O, De Lazzari E, Gatell JM.


Instruction: What did the Clinic Endocarditis Study Group study?

Output: Effect of vancomycin minimal inhibitory concentration on the outcome of methicillin-susceptible Staphylococcus aureus endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Clinic Endocarditis Study Group study?. ### Response: Effect of vancomycin minimal inhibitory concentration on the outcome of methicillin-susceptible Staphylococcus aureus endocarditis.


Instruction: What was the effect of vancomycin minimal inhibitory concentration on the outcome of methicillin-susceptible Staphylococcus aureus?

Output: Effect of vancomycin minimal inhibitory concentration on the outcome of methicillin-susceptible Staphylococcus aureus endocarditis. Clin Infect Dis. 2014;58:1668–1675. doi: 10.1093/cid/ciu183. 143

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the effect of vancomycin minimal inhibitory concentration on the outcome of methicillin-susceptible Staphylococcus aureus?. ### Response: Effect of vancomycin minimal inhibitory concentration on the outcome of methicillin-susceptible Staphylococcus aureus endocarditis. Clin Infect Dis. 2014;58:1668–1675. doi: 10.1093/cid/ciu183. 143.


Instruction: How did the study determine the outcome?

Output: Effect of vancomycin minimal inhibitory concentration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did the study determine the outcome?. ### Response: Effect of vancomycin minimal inhibitory concentration.


Instruction: How many cases of Staphylococcus lugdunensis infective endocarditis have been described?

Output: 10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many cases of Staphylococcus lugdunensis infective endocarditis have been described?. ### Response: 10.


Instruction: What is the name of the study group that studies St. Amphetis?

Output: Hospital Clinic Endocarditis Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study group that studies St. Amphetis?. ### Response: Hospital Clinic Endocarditis Study Group.


Instruction: What is the name of the study?

Output: Hospital Clinic Endocarditis Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study?. ### Response: Hospital Clinic Endocarditis Study Group.


Instruction: When was this study released?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this study released?. ### Response: April 28, 2023.


Instruction: What is NICE 2018?

Output: All rights reserved

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE 2018?. ### Response: All rights reserved.


Instruction: What are the Outcomes No of Participants (studies)?

Output: Follow up

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Outcomes No of Participants (studies)?. ### Response: Follow up.


Instruction: What is the GRADE of the evidence?

Output: Quality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the GRADE of the evidence?. ### Response: Quality.


Instruction: Anticipated absolute effects Risk with primary +/ - secondary care Risk difference with MDThome (95% CI) 0.5) Death 72 (1 study) 6 months  LOWb due to imprecision RR 2.00

Output: 978 -1-4731 -3093 -7 326 Outcomes  No of Participants (studies)  Follow up  Quality of the evidence  (GRADE)  Relative effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Anticipated absolute effects Risk with primary +/ - secondary care Risk difference with MDThome (95% CI) 0.5) Death 72 (1 study) 6 months  LOWb due to imprecision RR 2.00. ### Response: 978 -1-4731 -3093 -7 326 Outcomes  No of Participants (studies)  Follow up  Quality of the evidence  (GRADE)  Relative effect.


Instruction: LOWb due to imprecision RR 2.00 (0.66 to 6.06) 111 per 1000 111 more per 1 000 (from 38 fewer to 562 more) Quality of life EQ-5D final score appears to be what?

Output: EQ -5D visual analogue scale

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: LOWb due to imprecision RR 2.00 (0.66 to 6.06) 111 per 1000 111 more per 1 000 (from 38 fewer to 562 more) Quality of life EQ-5D final score appears to be what?. ### Response: EQ -5D visual analogue scale.


Instruction: What is the visual analogue scale?

Output: EQ -5D

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the visual analogue scale?. ### Response: EQ -5D.


Instruction: How long was the study?

Output: 6 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the study?. ### Response: 6 months.


Instruction: What was the mean quality of life in the control groups?

Output: 52.3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean quality of life in the control groups?. ### Response: 52.3.


Instruction: What was the mean quality of life in the intervention groups?

Output: 8.1 higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean quality of life in the intervention groups?. ### Response: 8.1 higher.


Instruction: How was the risk difference above 1000 calculated?

Output: Manually

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the risk difference above 1000 calculated?. ### Response: Manually.


Instruction: What was downgraded by one increment?

Output: confidence interval crossed 1 MID

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was downgraded by one increment?. ### Response: confidence interval crossed 1 MID.


Instruction: How many increments as the confidence interval crossed both MID s?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many increments as the confidence interval crossed both MID s?. ### Response: 2.


Instruction: What was downgraded by 1 increment if the majority of the evidence was at high risk of bias?

Output: confidence interval

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was downgraded by 1 increment if the majority of the evidence was at high risk of bias?. ### Response: confidence interval.


Instruction: What was at very high risk of bias?

Output: the majority of the evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was at very high risk of bias?. ### Response: the majority of the evidence.


Instruction: What was the high risk, Mid-length, MDT clinic?

Output: MDTc

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the high risk, Mid-length, MDT clinic?. ### Response: MDTc.


Instruction: What does GRADE stand for?

Output: Quality of the evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does GRADE stand for?. ### Response: Quality of the evidence.


Instruction: What percentage of the CI is for relative effect?

Output: 95%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the CI is for relative effect?. ### Response: 95%.


Instruction: What is the risk difference with MDTc (95% CI) Hospitalisations 230 (1 study) 6 months  LOW a, b due to risk of bias, imprecision rate ratio 0.68 (0.51 to 0.91) 983 per 1000 314 fewer admissions per 10 00 (from 88 to 88)

Output: Risk with primary/secondary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk difference with MDTc (95% CI) Hospitalisations 230 (1 study) 6 months  LOW a, b due to risk of bias, imprecision rate ratio 0.68 (0.51 to 0.91) 983 per 1000 314 fewer admissions per 10 00 (from 88 to 88). ### Response: Risk with primary/secondary.


Instruction: How many fewer admissions per 10 00 (from 88 fewer to 481 fewer) per 1000?

Output: 314

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many fewer admissions per 10 00 (from 88 fewer to 481 fewer) per 1000?. ### Response: 314.


Instruction: How many deaths per 1000 (1 study)?

Output: 111

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many deaths per 1000 (1 study)?. ### Response: 111.


Instruction: What is the LOWa, b RR 0.63?

Output: 0.32 to 165 per 1000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the LOWa, b RR 0.63?. ### Response: 0.32 to 165 per 1000.


Instruction: What is a risk of cardiovascular diseases and stroke events in methamphetamine users?

Output: Overweight and obesity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk of cardiovascular diseases and stroke events in methamphetamine users?. ### Response: Overweight and obesity.


Instruction: What is the name of the study that followed a 10-year follow-up study?

Output: J Clin Psychiatry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that followed a 10-year follow-up study?. ### Response: J Clin Psychiatry.


Instruction: How long did the study follow?

Output: 10-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the study follow?. ### Response: 10-year.


Instruction: What is the name of the population-based study of young adults who abuse am-phetamines or cocaine?

Output: Coronary Artery Risk Development in Young Adults (CARDIA) Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the population-based study of young adults who abuse am-phetamines or cocaine?. ### Response: Coronary Artery Risk Development in Young Adults (CARDIA) Study.


Instruction: What are the names of the patients who were studied in the 2007 study?

Output: 64:495–502

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the patients who were studied in the 2007 study?. ### Response: 64:495–502.


Instruction: What is the CARDIA Study?

Output: Coronary Artery Risk Development in Young Adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the CARDIA Study?. ### Response: Coronary Artery Risk Development in Young Adults.


Instruction: What is a possible cause of car-diovascular disease in middle age?

Output: Cumulative lifetime marijuana use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a possible cause of car-diovascular disease in middle age?. ### Response: Cumulative lifetime marijuana use.


Instruction: What was the name of the CARDIA study?

Output: Coronary Artery Risk Development in Young Adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the CARDIA study?. ### Response: Coronary Artery Risk Development in Young Adults.


Instruction: What is the citation for the CarDIA Study?

Output: Cochrane Database Syst Rev. 2018;7:CD007858

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the citation for the CarDIA Study?. ### Response: Cochrane Database Syst Rev. 2018;7:CD007858.


Instruction: How old are young cannabis users?

Output: 18–49 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old are young cannabis users?. ### Response: 18–49 years.


Instruction: In what year was the Int J Stroke published?

Output: 2020

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was the Int J Stroke published?. ### Response: 2020.


Instruction: What are the trends in hospitalizations and outcomes?

Output: Stroke in young cannabis users

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the trends in hospitalizations and outcomes?. ### Response: Stroke in young cannabis users.


Instruction: What is the int J Stroke. 2020;15:535–539.

Output: Stroke in young cannabis users (18–49 years): National trends in hospitalizations and outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the int J Stroke. 2020;15:535–539.. ### Response: Stroke in young cannabis users (18–49 years): National trends in hospitalizations and outcomes.


Instruction: What does Marijuana use among young adults (18-44 years of age) and risk of stroke?

Output: Behavioral Risk Factor Surveillance System Survey analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Marijuana use among young adults (18-44 years of age) and risk of stroke?. ### Response: Behavioral Risk Factor Surveillance System Survey analysis.


Instruction: What is the name of the study that examined treatment providers' perspectives and prac-tices?

Output: Addict Behav.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined treatment providers' perspectives and prac-tices?. ### Response: Addict Behav..


Instruction: What are the names of the studies that examined substance abuse treatment?

Output: Herbeck DM, Hser YI, Teruya C. Empirically supported substance abuse treat-ment approaches: a survey of treatment providers’ perspectives and prac-tices

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the studies that examined substance abuse treatment?. ### Response: Herbeck DM, Hser YI, Teruya C. Empirically supported substance abuse treat-ment approaches: a survey of treatment providers’ perspectives and prac-tices.


Instruction: Who is the World Health Organization?

Output: World Health Organization. Guidelines for the Psychosocially Assisted Pharmacological Treatment of Opioid Dependence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the World Health Organization?. ### Response: World Health Organization. Guidelines for the Psychosocially Assisted Pharmacological Treatment of Opioid Dependence.


Instruction: Who published the Guidelines for the Psychosocial Assisted Pharmacological Treatment of Opioid Dependence?

Output: World Health Organization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the Guidelines for the Psychosocial Assisted Pharmacological Treatment of Opioid Dependence?. ### Response: World Health Organization.


Instruction: What is the name of the systematic review of smoking cessation in smokers with cerebrovascular disease?

Output: The effectiveness of smoking cessation in-terventions in smokers with cerebrovascular disease: a systematic review. BMJ Open

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review of smoking cessation in smokers with cerebrovascular disease?. ### Response: The effectiveness of smoking cessation in-terventions in smokers with cerebrovascular disease: a systematic review. BMJ Open.


Instruction: What is the name of the systematic review of the BMJ Open in 2012?

Output: The effectiveness of smoking cessation in-terventions in smokers with cerebrovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review of the BMJ Open in 2012?. ### Response: The effectiveness of smoking cessation in-terventions in smokers with cerebrovascular disease.


Instruction: What does obesity and overweight have to do with improved survival, functional outcome, and stroke recurrence after acute stroke or transient ischaemic attack?

Output: associated with improved survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does obesity and overweight have to do with improved survival, functional outcome, and stroke recurrence after acute stroke or transient ischaemic attack?. ### Response: associated with improved survival.


Instruction: What is the name of the TEMPiS trial?

Output: Doehner W, Schenkel J, Anker SD, Springer J, Audebert HJ. Overweight and obesity are associated with improved survival, functional outcome, and stroke recurrence after acute stroke or transient ischaemic attack: observations from the TEMPiS trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the TEMPiS trial?. ### Response: Doehner W, Schenkel J, Anker SD, Springer J, Audebert HJ. Overweight and obesity are associated with improved survival, functional outcome, and stroke recurrence after acute stroke or transient ischaemic attack: observations from the TEMPiS trial.


Instruction: When was the Eur Heart J.34:268–277?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Eur Heart J.34:268–277?. ### Response: 2013.


Instruction: What is blood pressure-lowering treatment for preventing?

Output: recur-rent stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is blood pressure-lowering treatment for preventing?. ### Response: recur-rent stroke.


Instruction: What is the name of the randomised trial of perindopril-based blood-pressure lowering regimen among 6105 individuals with previous stroke or transient ischaemic attack?

Output: PROGRESS Collaborative Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised trial of perindopril-based blood-pressure lowering regimen among 6105 individuals with previous stroke or transient ischaemic attack?. ### Response: PROGRESS Collaborative Group.


Instruction: What is a neuromuscular dystrophy?

Output: Inheritance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a neuromuscular dystrophy?. ### Response: Inheritance.


Instruction: What are important for the initial clinical assess-ment, independent of symptom status?

Output: a 12-lead ECG and echocar -diogram

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are important for the initial clinical assess-ment, independent of symptom status?. ### Response: a 12-lead ECG and echocar -diogram.


Instruction: The more extensive the cardiac involvement, the more likely a VA will occur?

Output: includ-ing evidence of distal conduction disease, ven-tricular dysfunction, and atrial arrhythmias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The more extensive the cardiac involvement, the more likely a VA will occur?. ### Response: includ-ing evidence of distal conduction disease, ven-tricular dysfunction, and atrial arrhythmias.


Instruction: What is the most likely cause of VA?

Output: distal conduction disease, ven-tricular dysfunction, and atrial arrhythmias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most likely cause of VA?. ### Response: distal conduction disease, ven-tricular dysfunction, and atrial arrhythmias.


Instruction: What is included in the initial evaluation for myotonic dystrophy patients?

Output: ambula-tory monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is included in the initial evaluation for myotonic dystrophy patients?. ### Response: ambula-tory monitoring.


Instruction: Some experts advocate for an annual follow-up during what phase of the disease?

Output: concealed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Some experts advocate for an annual follow-up during what phase of the disease?. ### Response: concealed.


Instruction: What neuromuscular disorder is associated with heart disease?

Output: Muscular Dystrophy Inheritance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What neuromuscular disorder is associated with heart disease?. ### Response: Muscular Dystrophy Inheritance.


Instruction: What is the frequency of Cardiac Involvement Causes of DeathAssociated With Sudden Death?

Output: >90%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the frequency of Cardiac Involvement Causes of DeathAssociated With Sudden Death?. ### Response: >90%.


Instruction: What is the autosomal dominant Lamin A/C Conduction system disease and NICM>90% Sudden?

Output: HF Yes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the autosomal dominant Lamin A/C Conduction system disease and NICM>90% Sudden?. ### Response: HF Yes.


Instruction: Which type of girdle is Autosomal recessive Sarcoglycan?

Output: type 2C-2F

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which type of girdle is Autosomal recessive Sarcoglycan?. ### Response: type 2C-2F.


Instruction: What percentage of deaths are due to repeat expansion?

Output: 10%–25%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of deaths are due to repeat expansion?. ### Response: 10%–25%.


Instruction: What is the risk of repeat expansion due to NICM?

Output: nonisc

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of repeat expansion due to NICM?. ### Response: nonisc.


Instruction: How much of the deaths are caused by repeat expansion because of repeat growth?

Output: 10%–25%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the deaths are caused by repeat expansion because of repeat growth?. ### Response: 10%–25%.


Instruction: Which type of autosomal dominant CCTG repeat expansion is most common?

Output: Myotonic type 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which type of autosomal dominant CCTG repeat expansion is most common?. ### Response: Myotonic type 1.


Instruction: What indicates heart failure?

Output: HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates heart failure?. ### Response: HF.


Instruction: What is NICM?

Output: nonischemic cardiomyopathy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICM?. ### Response: nonischemic cardiomyopathy.


Instruction: When was this article originally published?

Output: April 23, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this article originally published?. ### Response: April 23, 2023.


Instruction: What should be a high level of concern for those patients with muscular dystrophy who present with arrhythmia symptoms?

Output: less frequent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be a high level of concern for those patients with muscular dystrophy who present with arrhythmia symptoms?. ### Response: less frequent.


Instruction: What does the current guideline focus on?

Output: VA and indications for implantation of an ICD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the current guideline focus on?. ### Response: VA and indications for implantation of an ICD.


Instruction: What is the current guideline on VA and indications for implantation of an ICD?

Output: S7.8-15

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the current guideline on VA and indications for implantation of an ICD?. ### Response: S7.8-15.


Instruction: What is discussed in another ACC/AHA/HRS guideline?

Output: The indications for permanent pacemaker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is discussed in another ACC/AHA/HRS guideline?. ### Response: The indications for permanent pacemaker.


Instruction: What are ICD recommendations for patients with NICM?

Output: Section 7.2.1 on Secondary Prevention and Section 7.2.2 on Primary Prevention of SCD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are ICD recommendations for patients with NICM?. ### Response: Section 7.2.1 on Secondary Prevention and Section 7.2.2 on Primary Prevention of SCD.


Instruction: What is warranted in patients with myotonic dystrophy who exhibit wide QRS complex tachycardia?

Output: A high index of suspicion for bundle-branch reentrant tachycardia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is warranted in patients with myotonic dystrophy who exhibit wide QRS complex tachycardia?. ### Response: A high index of suspicion for bundle-branch reentrant tachycardia.


Instruction: How much of all deaths from SCD are caused by Emery-Dreifuss and limb-girdle type 1B muscular dystrophies associated with Lamin A/C mutations?

Output: one third

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of all deaths from SCD are caused by Emery-Dreifuss and limb-girdle type 1B muscular dystrophies associated with Lamin A/C mutations?. ### Response: one third.


Instruction: What is the rate of appropriate ICD therapy in patients with cardiac conduction disorders?

Output: 52%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the rate of appropriate ICD therapy in patients with cardiac conduction disorders?. ### Response: 52%.


Instruction: What percentage of patients had isolated skeletal muscular involvement but included patients with conduction defects and other risk factors?

Output: 38%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients had isolated skeletal muscular involvement but included patients with conduction defects and other risk factors?. ### Response: 38%.


Instruction: What is therapy in patients with cardiac conduction disorders who are gene positive for Lamin A/C mutation?

Output: ICD therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is therapy in patients with cardiac conduction disorders who are gene positive for Lamin A/C mutation?. ### Response: ICD therapy.


Instruction: What percentage of VA patients received appropriate ICD therapy?

Output: 52%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of VA patients received appropriate ICD therapy?. ### Response: 52%.


Instruction: How many patients had LVEF 45%?

Output: 40%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had LVEF 45%?. ### Response: 40%.


Instruction: What was a study of patients who had Lamin A/C?

Output: S7.8-3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a study of patients who had Lamin A/C?. ### Response: S7.8-3.


Instruction: What percentage of patients with Lamin A/C mutation had a skeletal muscular dys-trophy phenotype?

Output: 21%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients with Lamin A/C mutation had a skeletal muscular dys-trophy phenotype?. ### Response: 21%.


Instruction: SCD and appropriate ICD ther -apy were associated with NSVT, LVEF 45%, male sex and what else?

Output: Lamin A/C nonmissense mutations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: SCD and appropriate ICD ther -apy were associated with NSVT, LVEF 45%, male sex and what else?. ### Response: Lamin A/C nonmissense mutations.


Instruction: These observational studies support the use of an ICD when a patient has what type of mutation?

Output: Lamin A/C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: These observational studies support the use of an ICD when a patient has what type of mutation?. ### Response: Lamin A/C.


Instruction: What type of studies support the use of an ICD when a pacing indication is present?

Output: observational

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of studies support the use of an ICD when a pacing indication is present?. ### Response: observational.


Instruction: What is an example of progressive cardiac involvement?

Output: cardiac conduction defects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of progressive cardiac involvement?. ### Response: cardiac conduction defects.


Instruction: There is a paucity of data regarding the rare form of what?

Output: x-linked recessive Emery-Dreifuss muscular dystrophy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is a paucity of data regarding the rare form of what?. ### Response: x-linked recessive Emery-Dreifuss muscular dystrophy.


Instruction: What is the rare form of x-linked recessive Emery-Dreifuss muscular dystrophy related to?

Output: Emerin gene mutation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the rare form of x-linked recessive Emery-Dreifuss muscular dystrophy related to?. ### Response: Emerin gene mutation.


Instruction: Arrhythmias may be less frequent than for what mutation?

Output: Lamin A/C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Arrhythmias may be less frequent than for what mutation?. ### Response: Lamin A/C.


Instruction: Cardiac involvement can occur in a number of what?

Output: neuromuscular dystrophies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cardiac involvement can occur in a number of what?. ### Response: neuromuscular dystrophies.


Instruction: What is the primary goal of the Kidney International Supplements?

Output: improve patient care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary goal of the Kidney International Supplements?. ### Response: improve patient care.


Instruction: What does the document aim to improve in the short term?

Output: patient care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the document aim to improve in the short term?. ### Response: patient care.


Instruction: How do we hope to improve patient care?

Output: by helpingclinicians know and better understand the evidence (or lackof evidence) that determines current practice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do we hope to improve patient care?. ### Response: by helpingclinicians know and better understand the evidence (or lackof evidence) that determines current practice.


Instruction: What determines current practice?

Output: evidence (or lackof evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What determines current practice?. ### Response: evidence (or lackof evidence.


Instruction: What is an often neglected but very important function of clinical practice guideline development?

Output: Helping to deﬁne a research agenda

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an often neglected but very important function of clinical practice guideline development?. ### Response: Helping to deﬁne a research agenda.


Instruction: What system did we use to rate the quality of evidence and the strength of recommenda-tions?

Output: Grading of Recommendations Assessment,Development and Evaluation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What system did we use to rate the quality of evidence and the strength of recommenda-tions?. ### Response: Grading of Recommendations Assessment,Development and Evaluation.


Instruction: How many recommendations were graded ‘A’ in this study?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many recommendations were graded ‘A’ in this study?. ### Response: 3.


Instruction: What percentage of recommendations were rated ‘B’?

Output: 18.2%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of recommendations were rated ‘B’?. ### Response: 18.2%).


Instruction: How many of the recommendations were graded ‘B’?

Output: 2 (18.2%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many of the recommendations were graded ‘B’?. ### Response: 2 (18.2%).


Instruction: How many recommendations were given a grade of ‘C,’ or ‘D?

Output: 2(18.2%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many recommendations were given a grade of ‘C,’ or ‘D?. ### Response: 2(18.2%).


Instruction: What is the correlation between the quality of evidence and the strength of the recommendation?

Output: acorrelation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the correlation between the quality of evidence and the strength of the recommendation?. ### Response: acorrelation.


Instruction: What percentage of recommendations were graded '1'?

Output: 36.4%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of recommendations were graded '1'?. ### Response: 36.4%).


Instruction: How many recommendations were '2C'graded?

Output: 2 (18.2%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many recommendations were '2C'graded?. ### Response: 2 (18.2%).


Instruction: What was the overall evidence and thestrength of the recommendation?

Output: quality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the overall evidence and thestrength of the recommendation?. ### Response: quality.


Instruction: What percentage of statements were not graded?

Output: 15.4%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of statements were not graded?. ### Response: 15.4%).


Instruction: What are clinicians still need to make in their daily practice?

Output: ecisions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are clinicians still need to make in their daily practice?. ### Response: ecisions.


Instruction: What do experts often ask?

Output: suggestions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do experts often ask?. ### Response: suggestions.


Instruction: What did we do instead of being silent?

Output: give guidance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did we do instead of being silent?. ### Response: give guidance.


Instruction: How are recommendations often rated?

Output: low strength of recommendation and a low qualityof evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are recommendations often rated?. ### Response: low strength of recommendation and a low qualityof evidence.


Instruction: What is important for the users of the guideline to be cognizant of?

Output: These recommendations are oftenrated with a low strength of recommendation and a low qualityof evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is important for the users of the guideline to be cognizant of?. ### Response: These recommendations are oftenrated with a low strength of recommendation and a low qualityof evidence.


Instruction: What is meant to be a place for clinicians to start, not stop?

Output: recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is meant to be a place for clinicians to start, not stop?. ### Response: recommendations.


Instruction: Who were the Co-Chairs of the Work Group?

Output: Drs.Marcello Tonelli

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who were the Co-Chairs of the Work Group?. ### Response: Drs.Marcello Tonelli.


Instruction: Who made this project possible?

Output: NationalKidney Foundation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who made this project possible?. ### Response: NationalKidney Foundation.


Instruction: Who owes a special debt of gratitude to?

Output: KDIGO Boardmembers and individuals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who owes a special debt of gratitude to?. ### Response: KDIGO Boardmembers and individuals.


Instruction: Who is the Co-Chair of Kidney International Supplements?

Output: David C Wheeler

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Co-Chair of Kidney International Supplements?. ### Response: David C Wheeler.


Instruction: What is the name of the co-chair of KDIGO?

Output: Bertram L Kasiske, MD David C Wheeler

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the co-chair of KDIGO?. ### Response: Bertram L Kasiske, MD David C Wheeler.


Instruction: What is the risk of terminal renal failure in proteinuric,non-diabetic nephropathy?

Output: glomerular ﬁltration rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of terminal renal failure in proteinuric,non-diabetic nephropathy?. ### Response: glomerular ﬁltration rate.


Instruction: What is ACE-inhibition used for?

Output: Renoprotective properties ofACE-inhibition in non-diabetic nephropathies with non-nephroticproteinuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ACE-inhibition used for?. ### Response: Renoprotective properties ofACE-inhibition in non-diabetic nephropathies with non-nephroticproteinuria.


Instruction: When did the Lancet issue 349:1857-1863.177?

Output: 1997

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Lancet issue 349:1857-1863.177?. ### Response: 1997.


Instruction: What is the angiotensin-converting-enzyme inhibitor benazepril used for?

Output: the progression of chronic renalinsuf ﬁciency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the angiotensin-converting-enzyme inhibitor benazepril used for?. ### Response: the progression of chronic renalinsuf ﬁciency.


Instruction: What is a ficiency in the progression of chronic renal insuf?

Output: angiotensin-converting-enzyme inhibitor benazepril

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a ficiency in the progression of chronic renal insuf?. ### Response: angiotensin-converting-enzyme inhibitor benazepril.


Instruction: Which group studied the effects of benazapril on the progression?

Output: Collaborative Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which group studied the effects of benazapril on the progression?. ### Response: Collaborative Study Group.


Instruction: What drug is used for advanced chronic renal insuf ficiency?

Output: Lisinopril

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug is used for advanced chronic renal insuf ficiency?. ### Response: Lisinopril.


Instruction: What is the name of the study that investigated the role of blood pressure control, proteinuria, and angiotensin-converting enzyme inhibition in the progression of chronic kidney disease?

Output: The Angiotensin-Converting-Enzyme Inhibition inProgressive Renal Insuf ﬁciency Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the role of blood pressure control, proteinuria, and angiotensin-converting enzyme inhibition in the progression of chronic kidney disease?. ### Response: The Angiotensin-Converting-Enzyme Inhibition inProgressive Renal Insuf ﬁciency Study Group.


Instruction: Inhibition: a patient-level meta-analysis.

Output: Renoprotective properties ofACE-inhibition in non-diabetic nephropathies with non-nephroticproteinuria. Lancet . 1999;354:359 –364.178. Maschio G, Alberti D, Janin G, et al. Effect of the angiotensin-converting-enzyme inhibitor benazepril on the progression of chronic renalinsuf ﬁciency. The Angiotensin-Converting-Enzyme Inhibition inProgressive Renal Insuf ﬁciency Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Inhibition: a patient-level meta-analysis.. ### Response: Renoprotective properties ofACE-inhibition in non-diabetic nephropathies with non-nephroticproteinuria. Lancet . 1999;354:359 –364.178. Maschio G, Alberti D, Janin G, et al. Effect of the angiotensin-converting-enzyme inhibitor benazepril on the progression of chronic renalinsuf ﬁciency. The Angiotensin-Converting-Enzyme Inhibition inProgressive Renal Insuf ﬁciency Study Group.


Instruction: What is the name of the randomized controlled study of benazepril andlosartan in chronic renal insuf ficiency?

Output: Renoprotection of Optimal AntiproteinuricDoses (ROAD) Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized controlled study of benazepril andlosartan in chronic renal insuf ficiency?. ### Response: Renoprotection of Optimal AntiproteinuricDoses (ROAD) Study.


Instruction: What is enalapril and beta blockers used for in non-diabetic chronic renal failure?

Output: Randomised controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is enalapril and beta blockers used for in non-diabetic chronic renal failure?. ### Response: Randomised controlled trial.


Instruction: What is the name of the subanalysis of the CombinationTherapy of Hypertension to Prevent in patients with CKD?

Output: Combination therapy forhypertension in patients with CKD: a subanalysis of the CombinationTherapy of Hypertension to Prevent Cardiovascular Events trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the subanalysis of the CombinationTherapy of Hypertension to Prevent in patients with CKD?. ### Response: Combination therapy forhypertension in patients with CKD: a subanalysis of the CombinationTherapy of Hypertension to Prevent Cardiovascular Events trial.


Instruction: What was a subanalysis of the CombinationTherapy of Hypertension to Prevent Cardiovascular Events trial?

Output: Combination therapy forhypertension in patients with CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a subanalysis of the CombinationTherapy of Hypertension to Prevent Cardiovascular Events trial?. ### Response: Combination therapy forhypertension in patients with CKD.


Instruction: What is the name of the study that investigated the effects of amlodipine andenalapril on renal function?

Output: The Angiotensin-Converting-Enzyme Inhibition inProgressive Renal Insuf ﬁciency Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the effects of amlodipine andenalapril on renal function?. ### Response: The Angiotensin-Converting-Enzyme Inhibition inProgressive Renal Insuf ﬁciency Study Group.


Instruction: What is the name of the 3-year, randomized, multicenter, double-blind, placebo-controlled study?

Output: Esnault VL, Brown EA, Apetrei E, et al. The effects of amlodipine andenalapril

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 3-year, randomized, multicenter, double-blind, placebo-controlled study?. ### Response: Esnault VL, Brown EA, Apetrei E, et al. The effects of amlodipine andenalapril.


Instruction: What is ESPIRALTrial?

Output: Effect of antihypertensive treatment onprogression of renal insuf ﬁciency in non-diabetics patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ESPIRALTrial?. ### Response: Effect of antihypertensive treatment onprogression of renal insuf ﬁciency in non-diabetics patients.


Instruction: What is the difference between captopril and nifedipine in the progression of renal insuf ficiency?

Output: Long-term comparison

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between captopril and nifedipine in the progression of renal insuf ficiency?. ### Response: Long-term comparison.


Instruction: When did KidneyInt. 1992 issue 42:452–458.187?

Output: 1992

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did KidneyInt. 1992 issue 42:452–458.187?. ### Response: 1992.


Instruction: What is securedundervascular compliance?

Output: angiotensin inhibition

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is securedundervascular compliance?. ### Response: angiotensin inhibition.


Instruction: What is secured under angiotensin inhibition in non-diabetic chronic kidney diseases?

Output: Vascular compliance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is secured under angiotensin inhibition in non-diabetic chronic kidney diseases?. ### Response: Vascular compliance.


Instruction: What is a controlled double-blind trial?

Output: Angiotensin-converting enzymeinhibition in nondiabetic progressive renal insuf ﬁciency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a controlled double-blind trial?. ### Response: Angiotensin-converting enzymeinhibition in nondiabetic progressive renal insuf ﬁciency.


Instruction: What is the name of the study that investigated the effect of Lisinoprilon on renal insuf ficiency in mild proteinuric non-alcoholics?

Output: Collaborative Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the effect of Lisinoprilon on renal insuf ficiency in mild proteinuric non-alcoholics?. ### Response: Collaborative Study Group.


Instruction: How many certification programs are available?

Output: 520

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many certification programs are available?. ### Response: 520.


Instruction: What may be insensitive to differentiating high-grade stenosis from complete occlusion?

Output: Duplex ultrasound

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be insensitive to differentiating high-grade stenosis from complete occlusion?. ### Response: Duplex ultrasound.


Instruction: What is the advantage of using MRA?

Output: providing images of both the cer -vical and intracranial portions of the carotid artery and its proximal intracranial branches

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the advantage of using MRA?. ### Response: providing images of both the cer -vical and intracranial portions of the carotid artery and its proximal intracranial branches.


Instruction: What may overestimate the degree of stenosis?

Output: MRA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may overestimate the degree of stenosis?. ### Response: MRA.


Instruction: What may occur when high-grade stenosis is differentiated from com-plete occlusion?

Output: errors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may occur when high-grade stenosis is differentiated from com-plete occlusion?. ### Response: errors.


Instruction: What may cause debilitating nephrogenic systemic fibrosis in patients with renal dysfunc-tion?

Output: MR contrast material

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may cause debilitating nephrogenic systemic fibrosis in patients with renal dysfunc-tion?. ### Response: MR contrast material.


Instruction: When concordant, the combination of duplex ultrasound and MRA is more accurate than what?

Output: either test alone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When concordant, the combination of duplex ultrasound and MRA is more accurate than what?. ### Response: either test alone.


Instruction: What is another method of identifying and measuring stenosis of the extracranial carotid artery?

Output: Computed tomographic angiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another method of identifying and measuring stenosis of the extracranial carotid artery?. ### Response: Computed tomographic angiography.


Instruction: Along with MRA, computed tomographic angiography has the advantage of being able to evaluate the intra-cranial circulation.

Output: 522

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Along with MRA, computed tomographic angiography has the advantage of being able to evaluate the intra-cranial circulation.. ### Response: 522.


Instruction: What may confound accurate measurement of stenosis with computed tomographic angiography?

Output: Atherosclerotic calcifi-cation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may confound accurate measurement of stenosis with computed tomographic angiography?. ### Response: Atherosclerotic calcifi-cation.


Instruction: A variety of vascular risk factors reviewed in this guideline are associated with what?

Output: carotid atherosclerosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A variety of vascular risk factors reviewed in this guideline are associated with what?. ### Response: carotid atherosclerosis.


Instruction: Carotid bruit can reflect an underlying which?

Output: carotid stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Carotid bruit can reflect an underlying which?. ### Response: carotid stenosis.


Instruction: What is the sen-sitivity for detecting carotid stenosis low?

Output: Carotid bruit can reflect an underlying carotid stenosis. However, the sen-sitivity for detecting carotid stenosis is low. In NOMAS, aus-cultation had a sensitivity of 56% and a specificity of 98%.525

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the sen-sitivity for detecting carotid stenosis low?. ### Response: Carotid bruit can reflect an underlying carotid stenosis. However, the sen-sitivity for detecting carotid stenosis is low. In NOMAS, aus-cultation had a sensitivity of 56% and a specificity of 98%.525.


Instruction: In NOMAS, aus-cultation had a sensitivity of what?

Output: 56%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In NOMAS, aus-cultation had a sensitivity of what?. ### Response: 56%.


Instruction: What was the first study with >1000 patients comparing CEA plus best medical therapy to medical therapy?

Output: Asymptomatic Carotid Atherosclerosis Study (ACAS).

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the first study with >1000 patients comparing CEA plus best medical therapy to medical therapy?. ### Response: Asymptomatic Carotid Atherosclerosis Study (ACAS)..


Instruction: What was the primary outcome of the Asymptomatic Carotid Atherosclerosis Study?

Output: the composite of any stroke or death occurring in the perioperative period and ipsilateral cerebral infarction thereafter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary outcome of the Asymptomatic Carotid Atherosclerosis Study?. ### Response: the composite of any stroke or death occurring in the perioperative period and ipsilateral cerebral infarction thereafter.


Instruction: How many patients did the Data and Safety Monitoring Committee randomize?

Output: 1662

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients did the Data and Safety Monitoring Committee randomize?. ### Response: 1662.


Instruction: What group called a halt to the trial because of a clear benefit in favor of CEA?

Output: Data and Safety Monitoring Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What group called a halt to the trial because of a clear benefit in favor of CEA?. ### Response: Data and Safety Monitoring Committee.


Instruction: Patients randomized to surgery had contrast angiography showing diameter-reducing lesions of  60% using the North American method of measurement?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients randomized to surgery had contrast angiography showing diameter-reducing lesions of  60% using the North American method of measurement?. ### Response: ≥.


Instruction: What was considered the best medical man-agement?

Output: contrast angiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was considered the best medical man-agement?. ### Response: contrast angiography.


Instruction: What was the overall risk over 5 years for ipsilateral stroke, any perioperative stroke and death?

Output: 5.1%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the overall risk over 5 years for ipsilateral stroke, any perioperative stroke and death?. ### Response: 5.1%.


Instruction: How much was the RR reduction for surgical patients?

Output: 53%;

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much was the RR reduction for surgical patients?. ### Response: 53%;.


Instruction: What was the RR reduction for CEA patients?

Output: 53%;

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the RR reduction for CEA patients?. ### Response: 53%;.


Instruction: How much was the 30-day stroke morbidity and all-cause mortality?

Output: 2.3%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much was the 30-day stroke morbidity and all-cause mortality?. ### Response: 2.3%,.


Instruction: What was a 1.2% stroke complication rate for catheter angiography?

Output: The 30-day stroke morbidity and all-cause mortality for CEA was 2.3%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a 1.2% stroke complication rate for catheter angiography?. ### Response: The 30-day stroke morbidity and all-cause mortality for CEA was 2.3%,.


Instruction: Why would complications of angiogram not be included in the risk of surgery?

Output: an angiogram would not have been performed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why would complications of angiogram not be included in the risk of surgery?. ### Response: an angiogram would not have been performed.


Instruction: What would not have been performed if surgery were not contemplated?

Output: an angiogram

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would not have been performed if surgery were not contemplated?. ### Response: an angiogram.


Instruction: What is the title of the 2018 ACHD GuidelineCirculation. 2019?

Output: Stout et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of the 2018 ACHD GuidelineCirculation. 2019?. ### Response: Stout et al.


Instruction: Who is the Director of the Adult Congenital Heart Service at Boston Children’s Hospital?

Output: Michael J. Landzberg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Director of the Adult Congenital Heart Service at Boston Children’s Hospital?. ### Response: Michael J. Landzberg.


Instruction: What institution is the Associate Professor of Medicine at Harvard Medical School?

Output: Boston Children’s Hospital

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What institution is the Associate Professor of Medicine at Harvard Medical School?. ### Response: Boston Children’s Hospital.


Instruction: What is Arwa Saidi Professor of at the University of Florida College of Medicine?

Output: Congenital Heart Center

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Arwa Saidi Professor of at the University of Florida College of Medicine?. ### Response: Congenital Heart Center.


Instruction: What is Anne Marie Valente Outpatient Director of at Boston Children’s Hospital?

Output: Boston Adult Congenital Heart Disease and Pulmonary Hypertension Service

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Anne Marie Valente Outpatient Director of at Boston Children’s Hospital?. ### Response: Boston Adult Congenital Heart Disease and Pulmonary Hypertension Service.


Instruction: Who is Associate Professor of Medicine at Harvard Medical School?

Output: Michael J. Landzberg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Associate Professor of Medicine at Harvard Medical School?. ### Response: Michael J. Landzberg.


Instruction: Who is the Director of Pediatric Cardiology at Washington University School of Medicine?

Output: George F. Van Hare

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Director of Pediatric Cardiology at Washington University School of Medicine?. ### Response: George F. Van Hare.


Instruction: What is the name of the co-director at St. Louis Children’s, Washington University Heart Center?

Output: George F. Van Hare

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the co-director at St. Louis Children’s, Washington University Heart Center?. ### Response: George F. Van Hare.


Instruction: What table represents the relationships of committee members with industry and other entities that were determined to be relevant to this document?

Output: ital Heart Disease and Pulmonary Hypertension Service

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What table represents the relationships of committee members with industry and other entities that were determined to be relevant to this document?. ### Response: ital Heart Disease and Pulmonary Hypertension Service.


Instruction: What does the table not reflect at the time of publication?

Output: relationships with industry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the table not reflect at the time of publication?. ### Response: relationships with industry.


Instruction: Who is deemed to have a significant interest in a business if the interest represents ownership of >5% of the voting stock or share of the business entity?

Output: A person

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is deemed to have a significant interest in a business if the interest represents ownership of >5% of the voting stock or share of the business entity?. ### Response: A person.


Instruction: How much of the fair market value of the business entity does the person own?

Output: >$5 000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the fair market value of the business entity does the person own?. ### Response: >$5 000.


Instruction: What percentage of the person's gross income for the previous year does the amount of funds received from a business entity exceed?

Output: 5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the person's gross income for the previous year does the amount of funds received from a business entity exceed?. ### Response: 5%.


Instruction: Relationships that exist with no business entity are called what?

Output: modest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Relationships that exist with no business entity are called what?. ### Response: modest.


Instruction: What are relationships that exist without financial benefit included for the purpose of transparency?

Output: modest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are relationships that exist without financial benefit included for the purpose of transparency?. ### Response: modest.


Instruction: Relationships in this table are modest unless what is noted?

Output: otherwise noted

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Relationships in this table are modest unless what is noted?. ### Response: otherwise noted.


Instruction: According to the ACC/AHA, a person has a relevant relationship if the relationship or interest relates to what?

Output: the same or similar subject matter, intellectual property or asset, topic, or issue addressed in the document

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: According to the ACC/AHA, a person has a relevant relationship if the relationship or interest relates to what?. ### Response: the same or similar subject matter, intellectual property or asset, topic, or issue addressed in the document.


Instruction: What does the company/entity make a drug, drug class, or device addressed in the document or makes a competing drug or device?

Output: b)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the company/entity make a drug, drug class, or device addressed in the document or makes a competing drug or device?. ### Response: b).


Instruction: Who has a reasonable potential for financial, professional or other personal gain or loss as a result of the issues/content addressed in the document?

Output: the person or a member of the person’s household

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who has a reasonable potential for financial, professional or other personal gain or loss as a result of the issues/content addressed in the document?. ### Response: the person or a member of the person’s household.


Instruction: When did the ACHD Guideline begin?

Output: March 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the ACHD Guideline begin?. ### Response: March 2014.


Instruction: What did the ACC and AHA not consider?

Output: minor charges relevant relationships with industry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the ACC and AHA not consider?. ### Response: minor charges relevant relationships with industry.


Instruction: Why have the ACC and AHA not considered these minor charges relevant relationships with industry?

Output: there have been issues related to accurate reporting of food and beverage payments

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why have the ACC and AHA not considered these minor charges relevant relationships with industry?. ### Response: there have been issues related to accurate reporting of food and beverage payments.


Instruction: What percentage of first-degree relatives are considered gene positive?

Output: 60% to 70%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of first-degree relatives are considered gene positive?. ### Response: 60% to 70%.


Instruction: What is the highest percentage of gene positive siblings?

Output: S7.3-1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the highest percentage of gene positive siblings?. ### Response: S7.3-1.


Instruction: What percentage of genes are gene positive?

Output: 60% to 70%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of genes are gene positive?. ### Response: 60% to 70%.


Instruction: What percentage is highest among siblings and those with symptoms?

Output: S7.3-1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage is highest among siblings and those with symptoms?. ### Response: S7.3-1.


Instruction: Screening for a specific mutation can identify some gene positive family members prior to what?

Output: disease expres-sion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Screening for a specific mutation can identify some gene positive family members prior to what?. ### Response: disease expres-sion.


Instruction: Syncope is reported in what percentage of arrhythmo-genic right ventricular arrhythmias?

Output: 16% to 39%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Syncope is reported in what percentage of arrhythmo-genic right ventricular arrhythmias?. ### Response: 16% to 39%.


Instruction: What percentage of arrhythmo-genic right ventricular cardiomyopathy patients are diagnosed?

Output: 16% to 39%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of arrhythmo-genic right ventricular cardiomyopathy patients are diagnosed?. ### Response: 16% to 39%.


Instruction: What is frequently exercise-related?

Output: S7.3-13,S7.3-14,S7.3-16,S7.3-41,S7.3-43

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is frequently exercise-related?. ### Response: S7.3-13,S7.3-14,S7.3-16,S7.3-41,S7.3-43.


Instruction: Syncope was an important pre-dictor of what?

Output: appropriate shocks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Syncope was an important pre-dictor of what?. ### Response: appropriate shocks.


Instruction: What was an important pre-dictor of appropriate shocks in 1 study?

Output: syncope

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was an important pre-dictor of appropriate shocks in 1 study?. ### Response: syncope.


Instruction: Studies have not provided information about what in patients with syncope?

Output: ventricular function or abnormalities on ECG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Studies have not provided information about what in patients with syncope?. ### Response: ventricular function or abnormalities on ECG.


Instruction: Syncope may be a harbinger of what?

Output: progression of underlying disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Syncope may be a harbinger of what?. ### Response: progression of underlying disease.


Instruction: What may be a harbinger of progression of underlying disease?

Output: Syncope

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be a harbinger of progression of underlying disease?. ### Response: Syncope.


Instruction: What should be integrated into the decision-making process for ICD implantation with the patient?

Output: Syncope

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be integrated into the decision-making process for ICD implantation with the patient?. ### Response: Syncope.


Instruction: Asymptomatic patients with arrhythmogenic right ventricular cardiomyopathy and no VA or ventric-ular dysfunction are generally observed without what?

Output: antiarrhythmic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Asymptomatic patients with arrhythmogenic right ventricular cardiomyopathy and no VA or ventric-ular dysfunction are generally observed without what?. ### Response: antiarrhythmic therapy.


Instruction: What can be performed to assess the adequacy of beta-blocking dosing?

Output: Ambulatory monitor -ing and/or exercise testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be performed to assess the adequacy of beta-blocking dosing?. ### Response: Ambulatory monitor -ing and/or exercise testing.


Instruction: What is the only antiarrhythmic therapy that can be used?

Output: beta-blocker therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the only antiarrhythmic therapy that can be used?. ### Response: beta-blocker therapy.


Instruction: Atenolol was shown to reduce VA in 1 study.

Output: S7.3-46,S7.3-47

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atenolol was shown to reduce VA in 1 study.. ### Response: S7.3-46,S7.3-47.


Instruction: How much of sponta-neous sustained VTs in arrhythmogenic right ven-tricular cardiomyopathy are monomorphic?

Output: >90%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of sponta-neous sustained VTs in arrhythmogenic right ven-tricular cardiomyopathy are monomorphic?. ### Response: >90%.


Instruction: What percentage of patients are induc-ible at electrophysiological study?

Output: 55%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients are induc-ible at electrophysiological study?. ### Response: 55%.


Instruction: What is associated with better outcomes in experienced centers?

Output: use of epicardial map-ping and ablation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with better outcomes in experienced centers?. ### Response: use of epicardial map-ping and ablation.


Instruction: What are some complications that occur in 2.3% to 3.3% of abla-tion cases?

Output: pericardial tamponade, MI, and death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some complications that occur in 2.3% to 3.3% of abla-tion cases?. ### Response: pericardial tamponade, MI, and death.


Instruction: The subepicardium has more extensive scar than what?

Output: endocardium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The subepicardium has more extensive scar than what?. ### Response: endocardium.


Instruction: What percentage of abla-tion cases have at least 1 recurrence?

Output: 27% to 55%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of abla-tion cases have at least 1 recurrence?. ### Response: 27% to 55%.


Instruction: Ablation reduces the frequency of what type of VT?

Output: recurrent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Ablation reduces the frequency of what type of VT?. ### Response: recurrent.


Instruction: What is the diagnosis of massive aortic aneu-rysm and dissection in repaired tetralogy of Fallot?

Output: cardiovascular magnetic resonance imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the diagnosis of massive aortic aneu-rysm and dissection in repaired tetralogy of Fallot?. ### Response: cardiovascular magnetic resonance imaging.


Instruction: What does the dilated as-cending Aorta do in an adult with congenital heart disease?

Output: require intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the dilated as-cending Aorta do in an adult with congenital heart disease?. ### Response: require intervention.


Instruction: What type of aortic stenosis does an adult with congenital heart disease need intervention for?

Output: supravalvar

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of aortic stenosis does an adult with congenital heart disease need intervention for?. ### Response: supravalvar.


Instruction: What is used to determine the timing of surgery for supravalvular Aortic Stenosis?

Output: doppler echocar -diography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used to determine the timing of surgery for supravalvular Aortic Stenosis?. ### Response: doppler echocar -diography.


Instruction: When did Am J Cardiol. 2000 issue 86:114-6?

Output: 2000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Am J Cardiol. 2000 issue 86:114-6?. ### Response: 2000.


Instruction: What is the potential surgical relevance of the aortic root in supravalvular stenosis?

Output: morphologic findings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the potential surgical relevance of the aortic root in supravalvular stenosis?. ### Response: morphologic findings.