Instruction: What percentage of women used anticoagulation for stroke reduction?

Output: 60%;

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of women used anticoagulation for stroke reduction?. ### Response: 60%;.


Instruction: What does the European Society of Cardiology recommend for patients with AF and a CHA2DS2-V ASc score 1.387?

Output: anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the European Society of Cardiology recommend for patients with AF and a CHA2DS2-V ASc score 1.387?. ### Response: anticoagulation.


Instruction: What is the Canadian Cardiovascular Society recommended for AF patients?

Output: anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Canadian Cardiovascular Society recommended for AF patients?. ### Response: anticoagulation.


Instruction: How many large observational studies provide some guidance?

Output: Two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many large observational studies provide some guidance?. ### Response: Two.


Instruction: What was the risk of stroke among patients with AF aged 65 years without risk fac-tors?

Output: lower risk of stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk of stroke among patients with AF aged 65 years without risk fac-tors?. ### Response: lower risk of stroke.


Instruction: How many patients with AF were included in a Danish study?

Output: 73 538

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with AF were included in a Danish study?. ### Response: 73 538.


Instruction: What was the long-term risk of thromboembolic events?

Output: 2.82

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the long-term risk of thromboembolic events?. ### Response: 2.82.


Instruction: What was the weaker risk factor for thromboembolic events?

Output: female sex alone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the weaker risk factor for thromboembolic events?. ### Response: female sex alone.


Instruction: What was female sex alone?

Output: weaker risk factor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was female sex alone?. ### Response: weaker risk factor.


Instruction: At 1-year follow-up, what was the increase in risk?

Output: 2.82

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: At 1-year follow-up, what was the increase in risk?. ### Response: 2.82.


Instruction: What is the 95% CI of thromboembolic events in women aged 65 to 74 years?

Output: 2.21–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 95% CI of thromboembolic events in women aged 65 to 74 years?. ### Response: 2.21–.


Instruction: What was the increase in risk of at 1 year?

Output: 2.82

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the increase in risk of at 1 year?. ### Response: 2.82.


Instruction: At 5 years, what was the increased risk?

Output: 2.10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: At 5 years, what was the increased risk?. ### Response: 2.10.


Instruction: How many years of follow-up did AHA recommend?

Output: 10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many years of follow-up did AHA recommend?. ### Response: 10.


Instruction: What is the AHA's recommendation based on?

Output: CHADS2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the AHA's recommendation based on?. ### Response: CHADS2.


Instruction: What percentage of patients have a CHADS2 score  2?

Output: The great majority of patients being assessed at stroke pre-vention clinics have a CHADS2 score ≥

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients have a CHADS2 score  2?. ### Response: The great majority of patients being assessed at stroke pre-vention clinics have a CHADS2 score ≥.


Instruction: The clinical situation with strong evidence in favor of anticoagulation is what?

Output: controversial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The clinical situation with strong evidence in favor of anticoagulation is what?. ### Response: controversial.


Instruction: What is a class I; Level of Evidence A?

Output: anticoagulation for high-risk patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a class I; Level of Evidence A?. ### Response: anticoagulation for high-risk patients.


Instruction: What do these data suggest that women, especially those aged  75 years, have a higher risk of?

Output: thromboembolic events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do these data suggest that women, especially those aged  75 years, have a higher risk of?. ### Response: thromboembolic events.


Instruction: Younger women (65 years old) with AF alone have what?

Output: lower risk of stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Younger women (65 years old) with AF alone have what?. ### Response: lower risk of stroke.


Instruction: What other risk factors have a lower risk of stroke?

Output: women (0.7%) and men

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What other risk factors have a lower risk of stroke?. ### Response: women (0.7%) and men.


Instruction: No specific sex benefits were observed when rate versus rhythm control strategies were compared?

Output: 390

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No specific sex benefits were observed when rate versus rhythm control strategies were compared?. ### Response: 390.


Instruction: What may be present that respond to revascularization and appropriate medical therapy?

Output: Regional wall motion abnormalities with reduced LV systolic functionLV dilation and systolic dysfunction attributable to primary myocardial diseaseSymptoms attributable to coronary ischemia or HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be present that respond to revascularization and appropriate medical therapy?. ### Response: Regional wall motion abnormalities with reduced LV systolic functionLV dilation and systolic dysfunction attributable to primary myocardial diseaseSymptoms attributable to coronary ischemia or HF.


Instruction: Asymptomatic severe MRRegurgitant fraction 50%Regional wall motion abnormalities with reduced what?

Output: LV systolic function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Asymptomatic severe MRRegurgitant fraction 50%Regional wall motion abnormalities with reduced what?. ### Response: LV systolic function.


Instruction: MRRegional wall motion abnormalities and/or LV dilation with severe tethering of what mitral leaflet?

Output: Annular dilation with severe loss of central coaptation of the mitral leaflets

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: MRRegional wall motion abnormalities and/or LV dilation with severe tethering of what mitral leaflet?. ### Response: Annular dilation with severe loss of central coaptation of the mitral leaflets.


Instruction: Regional dilation and systolic dysfunction attributable to what primary myocardial disease?

Output: coronary ischemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Regional dilation and systolic dysfunction attributable to what primary myocardial disease?. ### Response: coronary ischemia.


Instruction: What is a symptomatic severe MR?

Output: Regional wall motion abnormalities and/or LV dilation with severe tethering of mitral leaflet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a symptomatic severe MR?. ### Response: Regional wall motion abnormalities and/or LV dilation with severe tethering of mitral leaflet.


Instruction: What causes dilation with severe loss of central coaptation of the mitral leaflets?

Output: Annular

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes dilation with severe loss of central coaptation of the mitral leaflets?. ### Response: Annular.


Instruction: What is LV dilation and systolic dysfunction attributable to?

Output: primary myocardial disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is LV dilation and systolic dysfunction attributable to?. ### Response: primary myocardial disease.


Instruction: What type of criteria are provided for assessment of MR severity?

Output: valve hemodynamic criteria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of criteria are provided for assessment of MR severity?. ### Response: valve hemodynamic criteria.


Instruction: What depends on data quality and integration of data?

Output: Categorization of MR severity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What depends on data quality and integration of data?. ### Response: Categorization of MR severity.


Instruction: What depends on data quality and integration of these parameters in conjunction with other clinical evidence?

Output: Categorization of MR severity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What depends on data quality and integration of these parameters in conjunction with other clinical evidence?. ### Response: Categorization of MR severity.


Instruction: The measurement of the proximal isovelocity surface area by 2D TTE underestimates the true ERO because of the crescentic shape of what?

Output: proximal convergence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The measurement of the proximal isovelocity surface area by 2D TTE underestimates the true ERO because of the crescentic shape of what?. ### Response: proximal convergence.


Instruction: What shape of the proximal convergence may be lower in low-flow states?

Output: crescentic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What shape of the proximal convergence may be lower in low-flow states?. ### Response: crescentic.


Instruction: What indicates 2-dimensional?

Output: 2D

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates 2-dimensional?. ### Response: 2D.


Instruction: ERO, effective regurgitant orifice.

Output: ERO ≥0.40 cm2†Regurgitant volume ≥60 mL‡Regurgitant fraction ≥50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ERO, effective regurgitant orifice.. ### Response: ERO ≥0.40 cm2†Regurgitant volume ≥60 mL‡Regurgitant fraction ≥50%.


Instruction: What does LA mean?

Output: left atrium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does LA mean?. ### Response: left atrium.


Instruction: What does tranexamic acid reduce in off-pump coronary artery bypass surgery?

Output: blood loss

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does tranexamic acid reduce in off-pump coronary artery bypass surgery?. ### Response: blood loss.


Instruction: What is the name of the randomized, double-blind, placebo-controlled study of bleeding and fibrinolytic activity?

Output: tranexamic acid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized, double-blind, placebo-controlled study of bleeding and fibrinolytic activity?. ### Response: tranexamic acid.


Instruction: What reduces blood loss in off-pump coronary artery bypass surgery?

Output: Tranexamic acid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What reduces blood loss in off-pump coronary artery bypass surgery?. ### Response: Tranexamic acid.


Instruction: What does Tranexamic acid reduce?

Output: blood loss

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Tranexamic acid reduce?. ### Response: blood loss.


Instruction: When did Surgery. 1994:116:672–7.1053?

Output: 1994;116:672–7.1053. Nuttall GA, Oliver WC, Santrach PJ, et al. efficacy of a simpleintraoperative transfusion algorithm for nonerythrocyte component uti-lization after cardiopulmonary bypass

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Surgery. 1994:116:672–7.1053?. ### Response: 1994;116:672–7.1053. Nuttall GA, Oliver WC, Santrach PJ, et al. efficacy of a simpleintraoperative transfusion algorithm for nonerythrocyte component uti-lization after cardiopulmonary bypass.


Instruction: What is the name of the algorithm used for nonerythrocyte component uti-lization after cardiopulmonary bypass?

Output: simpleintraoperative transfusion algorithm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the algorithm used for nonerythrocyte component uti-lization after cardiopulmonary bypass?. ### Response: simpleintraoperative transfusion algorithm.


Instruction: When was the last time an algorithm was used to reduce haemostatic factor transfusion using thrombelastography?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last time an algorithm was used to reduce haemostatic factor transfusion using thrombelastography?. ### Response: 1999.


Instruction: What is a comparison of structureduse of routine laboratory tests or near-patient assessment with clinicaljudgement?

Output: management of bleeding after cardiac surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a comparison of structureduse of routine laboratory tests or near-patient assessment with clinicaljudgement?. ### Response: management of bleeding after cardiac surgery.


Instruction: What does routine laboratory tests or near-patient assessment have in the management of bleeding after cardiac surgery?

Output: clinicaljudgement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does routine laboratory tests or near-patient assessment have in the management of bleeding after cardiac surgery?. ### Response: clinicaljudgement.


Instruction: What is the effect of an intraop-erative treatment algorithm on physicians’ transfusion practice incardiac surgery.

Output: efficacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of an intraop-erative treatment algorithm on physicians’ transfusion practice incardiac surgery.. ### Response: efficacy.


Instruction: What does Thromboelastography-guided transfusion do?

Output: reduces transfusions in complex cardiacsurgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Thromboelastography-guided transfusion do?. ### Response: reduces transfusions in complex cardiacsurgery.


Instruction: What algorithm reduces transfusions in complex cardiacsurgery?

Output: Thromboelastography-guided transfusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What algorithm reduces transfusions in complex cardiacsurgery?. ### Response: Thromboelastography-guided transfusion.


Instruction: What does clopidogrel increase after coronary artery bypass surgery?

Output: blood loss

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does clopidogrel increase after coronary artery bypass surgery?. ### Response: blood loss.


Instruction: When did Ann Thorac Surg.78:1536–41.1059.

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Ann Thorac Surg.78:1536–41.1059.. ### Response: 2004.


Instruction: What is the effect of clopidogrel incoronary artery bypass grafting?

Output: Surgical bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of clopidogrel incoronary artery bypass grafting?. ### Response: Surgical bleeding.


Instruction: What are we forfeiting thebenefits of reduced hemorrhagic sequelae?

Output: Effect of clopidogrelpremedication in off-pump cardiac surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are we forfeiting thebenefits of reduced hemorrhagic sequelae?. ### Response: Effect of clopidogrelpremedication in off-pump cardiac surgery.


Instruction: What are hemorrhagic sequelae?

Output: romes without ST-segmentelevation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are hemorrhagic sequelae?. ### Response: romes without ST-segmentelevation.


Instruction: What is the effect of clopidogrel on bleeding andtransfusions after off-pump coronary artery bypass graft surgery?

Output: impact of discontinuation prior to surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of clopidogrel on bleeding andtransfusions after off-pump coronary artery bypass graft surgery?. ### Response: impact of discontinuation prior to surgery.


Instruction: What is a propensityscore analysis of preoperative clopidogrel in off pump coronary artery bypass surgery?

Output: Impact

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a propensityscore analysis of preoperative clopidogrel in off pump coronary artery bypass surgery?. ### Response: Impact.


Instruction: What is the name of the study that evaluated the effect of aspirin on acute coronary syndromes without ST-segmentelevation?

Output: N Engl J Med. 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated the effect of aspirin on acute coronary syndromes without ST-segmentelevation?. ### Response: N Engl J Med. 2011.


Instruction: What is the name of the journal that published the corrections?

Output: N Engl J Med.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that published the corrections?. ### Response: N Engl J Med..


Instruction: What was the title of the article that was published in 2011?

Output: 345:1716

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the title of the article that was published in 2011?. ### Response: 345:1716.


Instruction: How many patients were treated with unfractionated heparin and low molecular weight?

Output: 73.1065

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with unfractionated heparin and low molecular weight?. ### Response: 73.1065.


Instruction: What is the VA/DoD Clinical Practice Guideline for the Diagnosis and Management of Hypertensi on in the Primary Care Setting March 2020?

Output: Page 126 of 134

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for the Diagnosis and Management of Hypertensi on in the Primary Care Setting March 2020?. ### Response: Page 126 of 134.


Instruction: NHANES National Health and Nutrition Examination Survey NICE National Institute for Health and Care Excellence NPV

Output: negative predictive value

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: NHANES National Health and Nutrition Examination Survey NICE National Institute for Health and Care Excellence NPV. ### Response: negative predictive value.


Instruction: What is NPV negative predictive value OSA obstructive sleep apnea PCC patient centered care PICOTS population, intervention, comparison, outcome, timing and setting and setting?

Output: PREDIMED

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NPV negative predictive value OSA obstructive sleep apnea PCC patient centered care PICOTS population, intervention, comparison, outcome, timing and setting and setting?. ### Response: PREDIMED.


Instruction: What is PREDIMED PREvención con DIeta Mediterránea PVD perpherial vascular disease?

Output: PPV positive predictive value

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PREDIMED PREvención con DIeta Mediterránea PVD perpherial vascular disease?. ### Response: PPV positive predictive value.


Instruction: PREvención con DIeta Mediterránea PVD perpherial vascular disease RCT randomized control trial RHT resistant hypertension SBP systolic blood pr essure SDM shared decision making SLE systemic lupus erythematosus SME subject matter expert SMS short message service

Output: SPRINT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: PREvención con DIeta Mediterránea PVD perpherial vascular disease RCT randomized control trial RHT resistant hypertension SBP systolic blood pr essure SDM shared decision making SLE systemic lupus erythematosus SME subject matter expert SMS short message service. ### Response: SPRINT.


Instruction: What is the name of the SMS short message service?

Output: SPRINT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the SMS short message service?. ### Response: SPRINT.


Instruction: What is SR systematic review Tbsp tablespoon TOHP II Trials of Hypertension Prevention Phase II?

Output: Systolic Blood Pressure Intervention Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SR systematic review Tbsp tablespoon TOHP II Trials of Hypertension Prevention Phase II?. ### Response: Systolic Blood Pressure Intervention Trial.


Instruction: What is TOPCAT Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist trial?

Output: Non -pharmacologic Interventions in the Elderly

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is TOPCAT Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist trial?. ### Response: Non -pharmacologic Interventions in the Elderly.


Instruction: What is the name of the non pharmacologic intervention in the Elderly?

Output: TONE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the non pharmacologic intervention in the Elderly?. ### Response: TONE.


Instruction: How many potential strategies are there for anticoagulation?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many potential strategies are there for anticoagulation?. ### Response: 3.


Instruction: What are the three potential strategies?

Output: Continue warfa-rin throughout pregnancy; 2) use heparin throughout pregnancy; and 3) use sequential therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the three potential strategies?. ### Response: Continue warfa-rin throughout pregnancy; 2) use heparin throughout pregnancy; and 3) use sequential therapy.


Instruction: When is heparin used?

Output: throughout pregnancy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is heparin used?. ### Response: throughout pregnancy.


Instruction: Where is warfarin used during the second and third trimesters?

Output: sequential therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is warfarin used during the second and third trimesters?. ### Response: sequential therapy.


Instruction: What is the risk of catastrophic valve failure or stroke for women with mechanical heart valves?

Output: prohibitively high

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of catastrophic valve failure or stroke for women with mechanical heart valves?. ### Response: prohibitively high.


Instruction: What is a major cause of maternal morbidity and mortality during pregnancy?

Output: women who are not receiving appropriate doses of anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a major cause of maternal morbidity and mortality during pregnancy?. ### Response: women who are not receiving appropriate doses of anticoagulation.


Instruction: What is the cause of maternal morbidity and mortality during pregnancy?

Output: women who are not receiving appropriate doses of anticoagulation because of improper administration, improper monitoring, or medication nonadherence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cause of maternal morbidity and mortality during pregnancy?. ### Response: women who are not receiving appropriate doses of anticoagulation because of improper administration, improper monitoring, or medication nonadherence.


Instruction: What are women who are not receiving appropriate doses of anticoagulation at risk for?

Output: maternal morbidity and mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are women who are not receiving appropriate doses of anticoagulation at risk for?. ### Response: maternal morbidity and mortality.


Instruction: What is a prohibitive risk for pregnancy?

Output: Women who are not able to receive therapeutic anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a prohibitive risk for pregnancy?. ### Response: Women who are not able to receive therapeutic anticoagulation.


Instruction: No anticoagulation strategy is optimally safe for both the mother and the fetus?

Output: 13–153

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No anticoagulation strategy is optimally safe for both the mother and the fetus?. ### Response: 13–153.


Instruction: What does Warfarin cross the placenta and cause?

Output: fetal intracranial hemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Warfarin cross the placenta and cause?. ### Response: fetal intracranial hemorrhage.


Instruction: What does UFH and LMWH cross the placenta but are associated with higher rates of?

Output: maternal complications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does UFH and LMWH cross the placenta but are associated with higher rates of?. ### Response: maternal complications.


Instruction: What is the dose needed to maintain a therapeutic INR during pregnancy?

Output: warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the dose needed to maintain a therapeutic INR during pregnancy?. ### Response: warfarin.


Instruction: What is associated with higher rates of maternal complications than is seen with war -farin?

Output: Neither UFH nor LMWH crosses the placenta

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with higher rates of maternal complications than is seen with war -farin?. ### Response: Neither UFH nor LMWH crosses the placenta.


Instruction: What is an antico-agulation strategy that minimizes maternal risk?

Output: warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an antico-agulation strategy that minimizes maternal risk?. ### Response: warfarin.


Instruction: What does counseling and shared decision-making allow a woman and her physician to do?

Output: choose the best anticoagula-tion to achieve the woman’s goals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does counseling and shared decision-making allow a woman and her physician to do?. ### Response: choose the best anticoagula-tion to achieve the woman’s goals.


Instruction: What should physicians not assume or supplant their own preferences for?

Output: those of the patient

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should physicians not assume or supplant their own preferences for?. ### Response: those of the patient.


Instruction: What does warfarin do to the fetus and the mother?

Output: anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does warfarin do to the fetus and the mother?. ### Response: anticoagulation.


Instruction: What is the risk of fetal intracranial hemorrhage if the mother is fully antico-agulated with warfarine during vaginal delivery?

Output: higher risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of fetal intracranial hemorrhage if the mother is fully antico-agulated with warfarine during vaginal delivery?. ### Response: higher risk.


Instruction: When is the mother fully antico-agulated with warfarin during vaginal delivery?

Output: during the sec-ond and third trimesters

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is the mother fully antico-agulated with warfarin during vaginal delivery?. ### Response: during the sec-ond and third trimesters.


Instruction: What can women take to minimize the risk of coagulation for pregnant women?

Output: warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can women take to minimize the risk of coagulation for pregnant women?. ### Response: warfarin.


Instruction: • Most antih yper tensiv e medicines tak en while br eastfeeding only lead t o very low levels in br east milk?

Output: br eastf eeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: • Most antih yper tensiv e medicines tak en while br eastfeeding only lead t o very low levels in br east milk?. ### Response: br eastf eeding.


Instruction: T he amount s taken in b y babies ar e very small and would be unlik ely to have what?

Output: any clinical eff ect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: T he amount s taken in b y babies ar e very small and would be unlik ely to have what?. ### Response: any clinical eff ect.


Instruction: What would be unlik ely to have any clinical eff ect?

Output: most antih yper tensiv e medicines tak en while br eastf eeding only lead t o very low levels in br east milk, so t he amount s tak en in b y babies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would be unlik ely to have any clinical eff ect?. ### Response: most antih yper tensiv e medicines tak en while br eastf eeding only lead t o very low levels in br east milk, so t he amount s tak en in b y babies.


Instruction: Most medicines ar e not t ested in pr egnant or br eastfeeding what?

Output: w omen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Most medicines ar e not t ested in pr egnant or br eastfeeding what?. ### Response: w omen.


Instruction: Why should a woman make decisions about her breast milk?

Output: based on her preferences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why should a woman make decisions about her breast milk?. ### Response: based on her preferences.


Instruction: What are antih yper tensiv e agents able to do?

Output: transf er int o breast milk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are antih yper tensiv e agents able to do?. ### Response: transf er int o breast milk.


Instruction: What is the potential to transf er int o breast milk?

Output: antih yper tensiv e agent s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the potential to transf er int o breast milk?. ### Response: antih yper tensiv e agent s.


Instruction: Consider monit oring t he blood pr essur e of babies, especially those born preterm?

Output: antih yper tensiv e agent s have the pot ential t o transf er int o breast milk: • consider monit oring t he blood pr essur e of babies, especially t hose born preterm, who ha ve sympt oms of lo w blood pr essur e for the first f ew w eeks •

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Consider monit oring t he blood pr essur e of babies, especially those born preterm?. ### Response: antih yper tensiv e agent s have the pot ential t o transf er int o breast milk: • consider monit oring t he blood pr essur e of babies, especially t hose born preterm, who ha ve sympt oms of lo w blood pr essur e for the first f ew w eeks •.


Instruction: What should w omen do when discharging home?

Output: advise w omen t o monit or their babies f or dr ows

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should w omen do when discharging home?. ### Response: advise w omen t o monit or their babies f or dr ows.


Instruction: What is enalapril supposed to treat?

Output: h yper tension in w omen during t he postnatal period

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is enalapril supposed to treat?. ### Response: h yper tension in w omen during t he postnatal period.


Instruction: What are some factors that can cause tension in w omen during the postnatal period?

Output: mat ernal r enal function and maternal serum potassium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some factors that can cause tension in w omen during the postnatal period?. ### Response: mat ernal r enal function and maternal serum potassium.


Instruction: What is a factor that can contribute to hyper tension in women during t he postnatal periods?

Output: blood pr essur e is not contr olled wit h a single medicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a factor that can contribute to hyper tension in women during t he postnatal periods?. ### Response: blood pr essur e is not contr olled wit h a single medicine.


Instruction: For women of black African or Caribbean origin, consider what?

Output: antih yper tensiv e treatment wit h: • nifedipine[3] or • amlodipine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For women of black African or Caribbean origin, consider what?. ### Response: antih yper tensiv e treatment wit h: • nifedipine[3] or • amlodipine.


Instruction: What is an antihyper tensiv e treatment for hyper tension during t he postnatal period?

Output: nifedipine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an antihyper tensiv e treatment for hyper tension during t he postnatal period?. ### Response: nifedipine.


Instruction: What is nifedipine or amlodipine?

Output: nifedipine[3]

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is nifedipine or amlodipine?. ### Response: nifedipine[3].


Instruction: What is a combination of nifedipine and enalapril?

Output: amlodipine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a combination of nifedipine and enalapril?. ### Response: amlodipine.


Instruction: What is another name for amlodipine?

Output: nifedipine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for amlodipine?. ### Response: nifedipine.


Instruction: What can you do if your child is not tolerat ed or is ineff ectiv e?

Output: Make decisions on tr eatment t oget her wit h the w oman, based on her preferences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can you do if your child is not tolerat ed or is ineff ectiv e?. ### Response: Make decisions on tr eatment t oget her wit h the w oman, based on her preferences.


Instruction: What can be done if a child isn't tolerating enolol or labetalol?

Output: swapping 1  of the medicines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be done if a child isn't tolerating enolol or labetalol?. ### Response: swapping 1  of the medicines.


Instruction: What is labetalol?

Output: enolol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is labetalol?. ### Response: enolol.


Instruction: What is hyper tension in pregnancy?

Output: diagnosis and management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hyper tension in pregnancy?. ### Response: diagnosis and management.


Instruction: When was the last updat ed?

Output: 17 April 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last updat ed?. ### Response: 17 April 2023.


Instruction: Who is a founding KDIGO Co-Chair?

Output: David C Wheeler, MD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a founding KDIGO Co-Chair?. ### Response: David C Wheeler, MD.


Instruction: What is the name of the MD who was a co-chair?

Output: David C Wheeler

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the MD who was a co-chair?. ### Response: David C Wheeler.


Instruction: Who is an MD who has a PhD?

Output: Adrian Covic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is an MD who has a PhD?. ### Response: Adrian Covic.


Instruction: Which MD has an appointment as a board member?

Output: Garabed Eknoyan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which MD has an appointment as a board member?. ### Response: Garabed Eknoyan.


Instruction: MBA, FACHEDaniel C Cattran, MD, FRCPCAllan J Collins, MD and FACPRosanna Coppo, MDJosef Coresh, MD?

Output: Fred Brown, MBA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: MBA, FACHEDaniel C Cattran, MD, FRCPCAllan J Collins, MD and FACPRosanna Coppo, MDJosef Coresh, MD?. ### Response: Fred Brown, MBA.


Instruction: MDAdrian Covic, MD & PhDJonathan C Craig, MBChB, MM (Clin Epi), DCH, FRACP, PhDAngel de Francisco, MDPaul de Jong, MD& PhDAna Figueiredo, RN, MSc, BSc,

Output: 2012) 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: MDAdrian Covic, MD & PhDJonathan C Craig, MBChB, MM (Clin Epi), DCH, FRACP, PhDAngel de Francisco, MDPaul de Jong, MD& PhDAna Figueiredo, RN, MSc, BSc,. ### Response: 2012) 2.


Instruction: Benghanem Gharbi, MDGordon Guyatt, MD, MSc, BSc, FCPCDavid Harris, MDLai Seong Hooi, MDEnyu Imai, MD MS, FRCPMichel Jadoul, MDSimon Jenkins, MBE, FCGPSuhnggwon Kim, PhDMartin K Kuhlmann, MDNathan W Levin, MDPablo Massari, MPH, FACC, FACPPhillip K-T Li, MFP

Output: FACHEDaniel C Cattran, MD, FRCPCAllan J Collins, MD, FACPRosanna Coppo, MDJosef Coresh, MD, PhDRicardo Correa-Rotter, MDAdrian Covic, MD, PhDJonathan C Craig, MBChB, MM (Clin Epi), DCH, FRACP, PhDAngel de Francisco, MDPaul de Jong, MD, PhDAna Figueiredo, RN, MSc, PhDMohammed Benghanem Gharbi, MDGordon Guyatt, MD, MSc, BSc, FRCPCDavid Harris, MDLai Seong Hooi, MDEnyu Imai, MD, PhDLesley A Inker, MD, MS, FRCPMichel Jadoul, MDSimon Jenkins, MBE, FRCGPSuhnggwon

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Benghanem Gharbi, MDGordon Guyatt, MD, MSc, BSc, FCPCDavid Harris, MDLai Seong Hooi, MDEnyu Imai, MD MS, FRCPMichel Jadoul, MDSimon Jenkins, MBE, FCGPSuhnggwon Kim, PhDMartin K Kuhlmann, MDNathan W Levin, MDPablo Massari, MPH, FACC, FACPPhillip K-T Li, MFP. ### Response: FACHEDaniel C Cattran, MD, FRCPCAllan J Collins, MD, FACPRosanna Coppo, MDJosef Coresh, MD, PhDRicardo Correa-Rotter, MDAdrian Covic, MD, PhDJonathan C Craig, MBChB, MM (Clin Epi), DCH, FRACP, PhDAngel de Francisco, MDPaul de Jong, MD, PhDAna Figueiredo, RN, MSc, PhDMohammed Benghanem Gharbi, MDGordon Guyatt, MD, MSc, BSc, FRCPCDavid Harris, MDLai Seong Hooi, MDEnyu Imai, MD, PhDLesley A Inker, MD, MS, FRCPMichel Jadoul, MDSimon Jenkins, MBE, FRCGPSuhnggwon.


Instruction: Who is a FRCPCYusuke Tsukamoto?

Output: Marcello Tonelli

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a FRCPCYusuke Tsukamoto?. ### Response: Marcello Tonelli.


Instruction: What is the name of the GUIDELINE DEVELOPMENT STAFF?

Output: NKF-KDIGO

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the GUIDELINE DEVELOPMENT STAFF?. ### Response: NKF-KDIGO.


Instruction: Who is the senior vice-president for Scientific Activities?

Output: Kerry Willis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the senior vice-president for Scientific Activities?. ### Response: Kerry Willis.


Instruction: What is the name of the guideline development manager at Kidney International Supplements?

Output: Sean Slifer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the guideline development manager at Kidney International Supplements?. ### Response: Sean Slifer.


Instruction: What was the name of the trial that randomized 10,732 patients with STEMI toaspiration thrombectomy before primary PCI or primaryPCI only?

Output: The TOTAL (Trial of R outine Aspiration Throm-bectomy With PCI Versus PCI Alone in Patients WithSTEMI)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the trial that randomized 10,732 patients with STEMI toaspiration thrombectomy before primary PCI or primaryPCI only?. ### Response: The TOTAL (Trial of R outine Aspiration Throm-bectomy With PCI Versus PCI Alone in Patients WithSTEMI).


Instruction: What was performed in 7.1%of the primary PC I –only group?

Output: Bailout thrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was performed in 7.1%of the primary PC I –only group?. ### Response: Bailout thrombectomy.


Instruction: How many patients were randomized to the TOTAL trial?

Output: 10,732

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were randomized to the TOTAL trial?. ### Response: 10,732.


Instruction: What was the rate of cross-over from aspiration thrombectomy before primary PCI toprimary PCI only?

Output: 4.6%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the rate of cross-over from aspiration thrombectomy before primary PCI toprimary PCI only?. ### Response: 4.6%..


Instruction: What is the primary endpoint of cardiova scular death, recurrent MI,cardiogenic shock, or New York Heart Association class IVheart failure at 180 days?

Output: stent thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary endpoint of cardiova scular death, recurrent MI,cardiogenic shock, or New York Heart Association class IVheart failure at 180 days?. ### Response: stent thrombosis.


Instruction: How long did New York Heart Association class IVheart failure last?

Output: 180 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did New York Heart Association class IVheart failure last?. ### Response: 180 days.


Instruction: What was the primary endpoint of the study?

Output: stent thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary endpoint of the study?. ### Response: stent thrombosis.


Instruction: How many trials were included in an updated meta-analysis?

Output: 17

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many trials were included in an updated meta-analysis?. ### Response: 17.


Instruction: What was found to be no signi ficant reduction in death, reinfarction, orstent thrombosis?

Output: routine aspiration thrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was found to be no signi ficant reduction in death, reinfarction, orstent thrombosis?. ### Response: routine aspiration thrombectomy.


Instruction: What is a signi ficant reduction in death, reinfarction, orstent thrombosis with routine aspiration thrombectomy?

Output: major adverse cardiac events, stent thrombosis, and death(38–42). However, subgroup analyses from the TASTE andTOTAL trials did not suggest relative bene ﬁtf r o ma s p i r a -tion thrombectomy before primary PCI in patients withhigher thrombus burden or in pa tients with initial Throm-bolysis in Myocardial Infarction (TIMI) ﬂow grade 0 –1o rl e f tanterior descending artery/anterior infarction (34,35) .O nt h eb a s i so ft h er e s u l t so ft h e s es t u d i e s ,t h ep r i o rClass IIa recommendation for aspiration thrombectomyhas been changed. Routine aspiration thrombectomybefore primary PCI is now not recommended

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a signi ficant reduction in death, reinfarction, orstent thrombosis with routine aspiration thrombectomy?. ### Response: major adverse cardiac events, stent thrombosis, and death(38–42). However, subgroup analyses from the TASTE andTOTAL trials did not suggest relative bene ﬁtf r o ma s p i r a -tion thrombectomy before primary PCI in patients withhigher thrombus burden or in pa tients with initial Throm-bolysis in Myocardial Infarction (TIMI) ﬂow grade 0 –1o rl e f tanterior descending artery/anterior infarction (34,35) .O nt h eb a s i so ft h er e s u l t so ft h e s es t u d i e s ,t h ep r i o rClass IIa recommendation for aspiration thrombectomyhas been changed. Routine aspiration thrombectomybefore primary PCI is now not recommended.


Instruction: What has m a l lb u t increased in the risk of stroke?

Output: Aspiration thrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has m a l lb u t increased in the risk of stroke?. ### Response: Aspiration thrombectomy.


Instruction: How many previous studies have found that higherthrombus burden in patients?

Output: 35

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many previous studies have found that higherthrombus burden in patients?. ### Response: 35.


Instruction: How many previous studies have found that higherthrombus burden in patients with STEMI is independentlyassociated with higher risks of distal embolization?

Output: Several

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many previous studies have found that higherthrombus burden in patients with STEMI is independentlyassociated with higher risks of distal embolization?. ### Response: Several.


Instruction: What did subgroup analyses from the TASTE and TOTAL trials not suggest?

Output: relative bene

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did subgroup analyses from the TASTE and TOTAL trials not suggest?. ### Response: relative bene.


Instruction: What did not suggest relative bene fitf r o ma s p i ra tion thrombectomy before primary PCI?

Output: subgroup analyses from the TASTE andTOTAL trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did not suggest relative bene fitf r o ma s p i ra tion thrombectomy before primary PCI?. ### Response: subgroup analyses from the TASTE andTOTAL trials.


Instruction: What did trials not suggest in patients with higher thrombi burden or in pa tients with initial Throm-bolysis in Myocardial Infarction?

Output: relative bene ﬁtf r o ma s p i r a -tion thrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did trials not suggest in patients with higher thrombi burden or in pa tients with initial Throm-bolysis in Myocardial Infarction?. ### Response: relative bene ﬁtf r o ma s p i r a -tion thrombectomy.


Instruction: What is a class IIa recommendation for aspiration thrombectomy?

Output: Class IIb

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a class IIa recommendation for aspiration thrombectomy?. ### Response: Class IIb.


Instruction: What has been changed?

Output: Class IIa recommendation for aspiration thrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been changed?. ### Response: Class IIa recommendation for aspiration thrombectomy.


Instruction: What is no longer recommended before primary PCI?

Output: Routine aspiration thrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is no longer recommended before primary PCI?. ### Response: Routine aspiration thrombectomy.


Instruction: Forpatients undergoingprimary PCI (29-32), what is not well established?

Output: The usefulness ofselective andbailout aspirationthrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Forpatients undergoingprimary PCI (29-32), what is not well established?. ### Response: The usefulness ofselective andbailout aspirationthrombectomy.


Instruction: What does PCI indicate?

Output: percutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does PCI indicate?. ### Response: percutaneous coronary intervention.


Instruction: How is Routine aspirationthrombectomy before PCI?

Output: notuseful

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is Routine aspirationthrombectomy before PCI?. ### Response: notuseful.


Instruction: What is a new recommendation added forroutine aspirationthrombectomybefore PCI?

Output: “Class III: NoBeneﬁt

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a new recommendation added forroutine aspirationthrombectomybefore PCI?. ### Response: “Class III: NoBeneﬁt.


Instruction: What indicates percutaneous coronary intervention?

Output: PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates percutaneous coronary intervention?. ### Response: PCI.


Instruction: How many strokes were there in July of 2021?

Output: e378

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes were there in July of 2021?. ### Response: e378.


Instruction: What is the name of the 2021 guideline for secondary prevention of ischemic stroke?

Output: 2021 Guideline for the Secondary Prevention of Ischemic Strokedrawn from high-risk CVD and coronary heart disease populations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2021 guideline for secondary prevention of ischemic stroke?. ### Response: 2021 Guideline for the Secondary Prevention of Ischemic Strokedrawn from high-risk CVD and coronary heart disease populations.


Instruction: What are two examples of BP and cholesterol?

Output: high-risk CVD and coronary heart disease populations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are two examples of BP and cholesterol?. ### Response: high-risk CVD and coronary heart disease populations.


Instruction: What do epidemiological diet and nutrition studies identify protective effects for stroke from?

Output: regular consumption of fish

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do epidemiological diet and nutrition studies identify protective effects for stroke from?. ### Response: regular consumption of fish.


Instruction: High consumption of what foods can have protective effects on stroke?

Output: fruit and vegetables

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: High consumption of what foods can have protective effects on stroke?. ### Response: fruit and vegetables.


Instruction: What is the AHA/ACC guideline on lifestyle management to reduce cardiovascular risk?

Output: DASH (Dietary Approaches to Stop Hypertension) diet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the AHA/ACC guideline on lifestyle management to reduce cardiovascular risk?. ### Response: DASH (Dietary Approaches to Stop Hypertension) diet.


Instruction: What is PAR for stroke for the lowest versus the highest tertile of the modified Alternative Healthy Eating Index?

Output: 18.8%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PAR for stroke for the lowest versus the highest tertile of the modified Alternative Healthy Eating Index?. ### Response: 18.8%.


Instruction: The REGARDS cohort study was conducted in what country?

Output: United States

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The REGARDS cohort study was conducted in what country?. ### Response: United States.


Instruction: What did the REGARDS cohort study identify?

Output: higher adherence to the Southern diet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the REGARDS cohort study identify?. ### Response: higher adherence to the Southern diet.


Instruction: What diet was associated with a 39% increased risk of stroke?

Output: Southern diet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What diet was associated with a 39% increased risk of stroke?. ### Response: Southern diet.


Instruction: What is the HR of Sodium and potassium?

Output: 1.39

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the HR of Sodium and potassium?. ### Response: 1.39.


Instruction: What can be adjusted without altering overall dietary patterns?

Output: Sodium and potassium con-sumption

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be adjusted without altering overall dietary patterns?. ### Response: Sodium and potassium con-sumption.


Instruction: High potassium consumption106 and low salt consumption107 are associated with lower stroke rates.

Output: 26

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: High potassium consumption106 and low salt consumption107 are associated with lower stroke rates.. ### Response: 26.


Instruction: What does the PREDIMED trial consist of?

Output: interventional arms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the PREDIMED trial consist of?. ### Response: interventional arms.


Instruction: What is the name of the interventional arms of the trial?

Output: Prevención con Dieta Mediterránea

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the interventional arms of the trial?. ### Response: Prevención con Dieta Mediterránea.


Instruction: How is overnutrition addressed in Section 4.5?

Output: Obesity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is overnutrition addressed in Section 4.5?. ### Response: Obesity.


Instruction: What is the name of the trial that compares the Mediterranean diet with a low-fat diet?

Output: PREDIMED trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the trial that compares the Mediterranean diet with a low-fat diet?. ### Response: PREDIMED trial.


Instruction: What does Prevención con Dieta Mediterránea provide evidence of?

Output: a reduction in stroke events in individuals with high cardiovascular risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Prevención con Dieta Mediterránea provide evidence of?. ### Response: a reduction in stroke events in individuals with high cardiovascular risk.


Instruction: What is the primary end point for the Mediterranean diet with olive oil supplementation?

Output: adjusted HRs of 0.72

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary end point for the Mediterranean diet with olive oil supplementation?. ### Response: adjusted HRs of 0.72.


Instruction: What was the adjusted HRs for the control diet with nut supplementation compared with?

Output: 0.69

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the adjusted HRs for the control diet with nut supplementation compared with?. ### Response: 0.69.


Instruction: What did the Lyon Diet Heart trial show about the Mediterranean diet with supplemental canola compared with a usual post-MI prudent diet?

Output: low-quality evidence of reduced CVD mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Lyon Diet Heart trial show about the Mediterranean diet with supplemental canola compared with a usual post-MI prudent diet?. ### Response: low-quality evidence of reduced CVD mortality.


Instruction: What was the HR adjusted for?

Output: Mediterranean diet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the HR adjusted for?. ### Response: Mediterranean diet.


Instruction: How much of a difference was there between the adjusted HR and 95% CI?

Output: 0.69

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of a difference was there between the adjusted HR and 95% CI?. ### Response: 0.69.


Instruction: How much lower is each unit in MedDietScore associated with a 17% lower likelihood of ischemic stroke in a first stroke and matched control case?

Output: 1 of 55

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much lower is each unit in MedDietScore associated with a 17% lower likelihood of ischemic stroke in a first stroke and matched control case?. ### Response: 1 of 55.


Instruction: What is the 2013 ACC/AHA guide-line on the assessment of cardiovascular risk?

Output: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2013 ACC/AHA guide-line on the assessment of cardiovascular risk?. ### Response: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.


Instruction: What is a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines?

Output: ACC/AHA guide-line on the assessment of cardiovascular risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines?. ### Response: ACC/AHA guide-line on the assessment of cardiovascular risk.


Instruction: What is the name of the multi-ethnic study of atherosclerosis?

Output: MESA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multi-ethnic study of atherosclerosis?. ### Response: MESA.


Instruction: What does MESA stand for?

Output: Multi-Ethnic Study of Atherosclerosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does MESA stand for?. ### Response: Multi-Ethnic Study of Atherosclerosis.


Instruction: How many people have a family history for coronary heart disease?

Output: 35

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people have a family history for coronary heart disease?. ### Response: 35.


Instruction: What is the association of coronary artery calcium in adults aged 32 to 64?

Output: coronary heart disease risk prediction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association of coronary artery calcium in adults aged 32 to 64?. ### Response: coronary heart disease risk prediction.


Instruction: What was the multi-ethnic study of atherosclerosis?

Output: MESA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the multi-ethnic study of atherosclerosis?. ### Response: MESA.


Instruction: What is the association of coronary artery calcium in adults aged 32 to 46 years with incident coronary heart disease and death?

Output: S4.4.2-37

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association of coronary artery calcium in adults aged 32 to 46 years with incident coronary heart disease and death?. ### Response: S4.4.2-37.


Instruction: JAMA Cardiol. 2017;2:391-9. S4.4.2-37.

Output: coronary artery calcium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: JAMA Cardiol. 2017;2:391-9. S4.4.2-37.. ### Response: coronary artery calcium.


Instruction: When did Data Brief. 2016;6:578-81.

Output: Data on coronary artery calcium score performance and cardiovascular risk reclassification across gender and ethnicities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Data Brief. 2016;6:578-81.. ### Response: Data on coronary artery calcium score performance and cardiovascular risk reclassification across gender and ethnicities.


Instruction: What is risk reclassification across gender and ethnicities?

Output: cardiovascular

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is risk reclassification across gender and ethnicities?. ### Response: cardiovascular.


Instruction: What is associated with initiation and continuation of pharmacological and lifestyle preventive therapies?

Output: The identification of calcified coronary plaque

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with initiation and continuation of pharmacological and lifestyle preventive therapies?. ### Response: The identification of calcified coronary plaque.


Instruction: What is the name of the meta-analysis?

Output: Multi-Ethnic Study of Atherosclerosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis?. ### Response: Multi-Ethnic Study of Atherosclerosis.


Instruction: What is ACC/AHA guidelines for statin treatment strategy in asymptomatic Korean adults?

Output: Assessment of coronary artery calcium scoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ACC/AHA guidelines for statin treatment strategy in asymptomatic Korean adults?. ### Response: Assessment of coronary artery calcium scoring.


Instruction: How is the cost-effectiveness of coronary artery calcium scoring determined?

Output: according to the American College of Cardiology and American Heart Association cholesterol guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the cost-effectiveness of coronary artery calcium scoring determined?. ### Response: according to the American College of Cardiology and American Heart Association cholesterol guidelines.


Instruction: What is the cost-effectiveness of coronary artery calcium testing among statin candidates?

Output: Cost-effectiveness of coronary artery calcium testing among statin candidates according to the American College of Cardiology and American Heart Association cholesterol guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cost-effectiveness of coronary artery calcium testing among statin candidates?. ### Response: Cost-effectiveness of coronary artery calcium testing among statin candidates according to the American College of Cardiology and American Heart Association cholesterol guidelines.


Instruction: What are the American College of Cardiology and American Heart Association cholesterol guidelines?

Output: Cost-effectiveness of coronary artery calcium testing among statin candidates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the American College of Cardiology and American Heart Association cholesterol guidelines?. ### Response: Cost-effectiveness of coronary artery calcium testing among statin candidates.


Instruction: How does CAC score improve coronary and CV risk assessment?

Output: above statin indication by ESC and AHA/ACC primary prevention guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does CAC score improve coronary and CV risk assessment?. ### Response: above statin indication by ESC and AHA/ACC primary prevention guidelines.


Instruction: What is a meta-analysis of prevalence and prognostic implications of coronary artery calcification?

Output: pharmacological and lifestyle preventive therapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a meta-analysis of prevalence and prognostic implications of coronary artery calcification?. ### Response: pharmacological and lifestyle preventive therapies.


Instruction: What are ESC and AHA/ACC primary prevention guidelines?

Output: CAC score improves coronary and CV risk assessment above statin indication

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are ESC and AHA/ACC primary prevention guidelines?. ### Response: CAC score improves coronary and CV risk assessment above statin indication.


Instruction: What is the J Am Coll Cardiol Img. 2017;10:143-53?

Output: HA/ACC primary prevention guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the J Am Coll Cardiol Img. 2017;10:143-53?. ### Response: HA/ACC primary prevention guidelines.


Instruction: How long does it take to predict coronary heart disease?

Output: 10-Year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take to predict coronary heart disease?. ### Response: 10-Year.


Instruction: What is MESA?

Output: Multi-Ethnic Study of Atherosclerosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is MESA?. ### Response: Multi-Ethnic Study of Atherosclerosis.


Instruction: What is DHS?

Output: Dallas Heart Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is DHS?. ### Response: Dallas Heart Study.


Instruction: How many people were enrolled in the HNR study?

Output: Heinz Nixdorf Recall) Study and the DHS (Dallas Heart Study) J Am Coll Cardiol. 2015;66:1643–53

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were enrolled in the HNR study?. ### Response: Heinz Nixdorf Recall) Study and the DHS (Dallas Heart Study) J Am Coll Cardiol. 2015;66:1643–53.


Instruction: What is calcification associated with?

Output: initiation and continuation of pharmacological and lifestyle preventive therapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is calcification associated with?. ### Response: initiation and continuation of pharmacological and lifestyle preventive therapies.


Instruction: What is the name of the journal that deals with cardiovascular events?

Output: JAMA Cardiol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that deals with cardiovascular events?. ### Response: JAMA Cardiol.


Instruction: When was the JAMA published?

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the JAMA published?. ### Response: 2016.


Instruction: What is the name of the guideline for pharmacologic treatment of hypertension in adults aged 60 years or older?

Output: A ClinicalPractice Guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the guideline for pharmacologic treatment of hypertension in adults aged 60 years or older?. ### Response: A ClinicalPractice Guideline.


Instruction: Who is the author of the ClinicalPractice Guideline for Pharmacologic Treatment of Hypertension?

Output: Amir Qaseem, MD, PhD, MHA; Timothy J. Wilt, MD, MPH; Robert Rich, MD; Linda L. Humphrey, MD, MPH; Jennifer Frost, MD; andMary Ann Forciea

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of the ClinicalPractice Guideline for Pharmacologic Treatment of Hypertension?. ### Response: Amir Qaseem, MD, PhD, MHA; Timothy J. Wilt, MD, MPH; Robert Rich, MD; Linda L. Humphrey, MD, MPH; Jennifer Frost, MD; andMary Ann Forciea.


Instruction: Who is a member of the Clinical Guidelines Committee of the American College of Physicians and the Commission onHealth of the Public and Science?

Output: Mary Ann Forciea

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a member of the Clinical Guidelines Committee of the American College of Physicians and the Commission onHealth of the Public and Science?. ### Response: Mary Ann Forciea.


Instruction: What is the ACP?

Output: AmericanCollegeofPhysicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ACP?. ### Response: AmericanCollegeofPhysicians.


Instruction: What does AAFP stand for?

Output: American Academy of Family Physicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does AAFP stand for?. ### Response: American Academy of Family Physicians.


Instruction: In what age group is this guideline based?

Output: 60 years or older

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what age group is this guideline based?. ### Response: 60 years or older.


Instruction: How old is the target age?

Output: 60 years or older

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old is the target age?. ### Response: 60 years or older.


Instruction: What are the main outcomes of the study?

Output: all-cause mortality,morbidity and mortality related to stroke, major cardiac events(fatal and nonfatal myocardial infarction and sudden cardiacdeath), and harms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the main outcomes of the study?. ### Response: all-cause mortality,morbidity and mortality related to stroke, major cardiac events(fatal and nonfatal myocardial infarction and sudden cardiacdeath), and harms.


Instruction: How long did the database exist?

Output: throughJanuary 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the database exist?. ### Response: throughJanuary 2015.


Instruction: What is the name of the method used to grade the evidence and recommendations?

Output: GRADE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the method used to grade the evidence and recommendations?. ### Response: GRADE.


Instruction: Who is the target audience for this guideline?

Output: Patient Population

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the target audience for this guideline?. ### Response: Patient Population.


Instruction: Who is included in the guideline?

Output: Target Audience and Patient Population

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is included in the guideline?. ### Response: Target Audience and Patient Population.


Instruction: What is the target population?

Output: all clinicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the target population?. ### Response: all clinicians.


Instruction: Who recommends that clinicians start treatment in adults aged 60 years or older with hypertension?

Output: ACP and AAFP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who recommends that clinicians start treatment in adults aged 60 years or older with hypertension?. ### Response: ACP and AAFP.


Instruction: What is a target systolic blood pressure of less than 150 mm Hg to reduce the risk for stroke, cardiac events, and possibly mortality?

Output: systolicblood pressure persistently at or above 150 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a target systolic blood pressure of less than 150 mm Hg to reduce the risk for stroke, cardiac events, and possibly mortality?. ### Response: systolicblood pressure persistently at or above 150 mm Hg.


Instruction: ACP and AAFP recommend that clinicians select the treatment goals for adults aged 60 years or older based on a periodic what?

Output: discussion of thebeneﬁts and harms of speciﬁc blood pressure targets with thepatient

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ACP and AAFP recommend that clinicians select the treatment goals for adults aged 60 years or older based on a periodic what?. ### Response: discussion of thebeneﬁts and harms of speciﬁc blood pressure targets with thepatient.


Instruction: ACP and AAFP recommend that clinicians consider initiating or intensifying pharmacologic treatment in adults aged 60 years or older?

Output: systolicblood pressure persistently at or above 150 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ACP and AAFP recommend that clinicians consider initiating or intensifying pharmacologic treatment in adults aged 60 years or older?. ### Response: systolicblood pressure persistently at or above 150 mm Hg.


Instruction: What should a person with a history of stroke or transientischemic attack achieve to reduce the risk for recurrent stroke?

Output: a target systolic blood pressure of lessthan 140 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should a person with a history of stroke or transientischemic attack achieve to reduce the risk for recurrent stroke?. ### Response: a target systolic blood pressure of lessthan 140 mm Hg.


Instruction: What do ACP and AAFP recommend that clinicians discuss with patients about the benefits and harms of specific blood pressure targets?

Output: treatment goals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do ACP and AAFP recommend that clinicians discuss with patients about the benefits and harms of specific blood pressure targets?. ### Response: treatment goals.


Instruction: What was the most common underlying condition predisposing to endocarditis?

Output: RHD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the most common underlying condition predisposing to endocarditis?. ### Response: RHD.


Instruction: How many cases of IE per 100 000 person-years were reported in Olmsted County, Minnesota?

Output: 5 to 7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many cases of IE per 100 000 person-years were reported in Olmsted County, Minnesota?. ### Response: 5 to 7.


Instruction: What is still common in developing countries?

Output: RHD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is still common in developing countries?. ### Response: RHD.


Instruction: What is now the most common underlyingcondition in patients with endocarditis?

Output: MVP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is now the most common underlyingcondition in patients with endocarditis?. ### Response: MVP.


Instruction: How many published data quantitate the lifetime risk of acquisi-tion of IE associated with a specific underlying cardiaccondition?

Output: Few

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many published data quantitate the lifetime risk of acquisi-tion of IE associated with a specific underlying cardiaccondition?. ### Response: Few.


Instruction: What is IE associated with?

Output: a specific underlying cardiaccondition

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is IE associated with?. ### Response: a specific underlying cardiaccondition.


Instruction: Who reported the lifetime risk of acquisition of IE?

Output: Steckelberg and Wilson

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who reported the lifetime risk of acquisition of IE?. ### Response: Steckelberg and Wilson.


Instruction: How many per 100 000 patient-years did Steckelberg and Wilson90 report?

Output: 5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many per 100 000 patient-years did Steckelberg and Wilson90 report?. ### Response: 5.


Instruction: What was the risk of acquired IE in patients with no known cardiacconditions?

Output: 5 per 100 000patient-years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk of acquired IE in patients with no known cardiacconditions?. ### Response: 5 per 100 000patient-years.


Instruction: What was the risk of IE per 100 000 patient-years in patients with MVP without an audible cardiacmurmur?

Output: 4.6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk of IE per 100 000 patient-years in patients with MVP without an audible cardiacmurmur?. ### Response: 4.6.


Instruction: How was the lifetimerisk for RHD?

Output: 380 to 440

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the lifetimerisk for RHD?. ### Response: 380 to 440.


Instruction: What was the lifetime risk for RHD?

Output: 380 to 440

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the lifetime risk for RHD?. ### Response: 380 to 440.


Instruction: What were the highest lifetime risks per 100 000 patient-years?

Output: cardiac valve replacement surgery for native valveIE, 630; previous IE, 740

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the highest lifetime risks per 100 000 patient-years?. ### Response: cardiac valve replacement surgery for native valveIE, 630; previous IE, 740.


Instruction: How many patients had previous IE?

Output: 740

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had previous IE?. ### Response: 740.


Instruction: What was the risk of IE before closure of a ventricular septal defect in a separate study?

Output: more than twice that after closure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk of IE before closure of a ventricular septal defect in a separate study?. ### Response: more than twice that after closure.


Instruction: How many previous IEs were there in patients with prosthetic valve endocarditis?

Output: 740

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many previous IEs were there in patients with prosthetic valve endocarditis?. ### Response: 740.


Instruction: What was the risk of IE before closure of a ventricular septal defect?

Output: more than twice that after closure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk of IE before closure of a ventricular septal defect?. ### Response: more than twice that after closure.


Instruction: What is difficult to use these data to define accurately?

Output: the lifetime riskof acquisition of IE in an individual patient with a specificunderlying cardiac risk factor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is difficult to use these data to define accurately?. ### Response: the lifetime riskof acquisition of IE in an individual patient with a specificunderlying cardiac risk factor.


Instruction: What is the risk of IE in an individual patient with a specificunderlying cardiac risk factor?

Output: lifetime riskof acquisition

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of IE in an individual patient with a specificunderlying cardiac risk factor?. ### Response: lifetime riskof acquisition.


Instruction: What is based in parton the fact that each individual cardiac condition represents a broad spectrum of pathology fromminimal to severe?

Output: difficult to utilize them to define accurately the lifetime riskof acquisition of IE in an individual patient with a specificunderlying cardiac risk factor. This difficulty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is based in parton the fact that each individual cardiac condition represents a broad spectrum of pathology fromminimal to severe?. ### Response: difficult to utilize them to define accurately the lifetime riskof acquisition of IE in an individual patient with a specificunderlying cardiac risk factor. This difficulty.


Instruction: What would likely be influenced by the severity of valvular disease?

Output: the risk of IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would likely be influenced by the severity of valvular disease?. ### Response: the risk of IE.


Instruction: What is another underlying condition with multiple differ-ent cardiac abnormalities?

Output: CHD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another underlying condition with multiple differ-ent cardiac abnormalities?. ### Response: CHD.


Instruction: During the past 25years, there has been an increasing use of what?

Output: intracardiacvalvular prostheses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: During the past 25years, there has been an increasing use of what?. ### Response: intracardiacvalvular prostheses.


Instruction: What types of prostheses are used for repair of valvular heart disease and CHD?

Output: intracardiacvalvular

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What types of prostheses are used for repair of valvular heart disease and CHD?. ### Response: intracardiacvalvular.


Instruction: What are the different levels of risk for acquisition of IE?

Output: 5 per 100 000patient-years in the general population with no known cardiacconditions to 2160 per 100 000 patient-years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the different levels of risk for acquisition of IE?. ### Response: 5 per 100 000patient-years in the general population with no known cardiacconditions to 2160 per 100 000 patient-years.


Instruction: What is the true risk of acquisition of IE in patients with a specific underlyingcardiac condition?

Output: lifetime

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the true risk of acquisition of IE in patients with a specific underlyingcardiac condition?. ### Response: lifetime.


Instruction: On the basis of the data from Steckelberg and Wilson, what was assessed?

Output: lifetime riskof acquisition of IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On the basis of the data from Steckelberg and Wilson, what was assessed?. ### Response: lifetime riskof acquisition of IE.


Instruction: What type of hypercholesterolemia is based on family history?

Output: severe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of hypercholesterolemia is based on family history?. ### Response: severe.


Instruction: What is one advantage of measuring lipids in a family?

Output: to identify genetic abnormali-ties in lipid metabolism that may be present in other family members

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one advantage of measuring lipids in a family?. ### Response: to identify genetic abnormali-ties in lipid metabolism that may be present in other family members.


Instruction: What is one advantage of measuring lipids in children and adolescents?

Output: to identify genetic abnormali-ties in lipid metabolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one advantage of measuring lipids in children and adolescents?. ### Response: to identify genetic abnormali-ties in lipid metabolism.


Instruction: What is highly effective for the identification of family members with abnormalities?

Output: reverse-cas-cade screening

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is highly effective for the identification of family members with abnormalities?. ### Response: reverse-cas-cade screening.


Instruction: What is highly effective for the identification of family members at risk of ASCVD?

Output: reverse-cas-cade screening in families

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is highly effective for the identification of family members at risk of ASCVD?. ### Response: reverse-cas-cade screening in families.


Instruction: What do observa-tions of children and adolescents show?

Output: obesity and other lifestyle-related behaviors and metabolic syndrome risk fac-tors including lipid abnormalities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do observa-tions of children and adolescents show?. ### Response: obesity and other lifestyle-related behaviors and metabolic syndrome risk fac-tors including lipid abnormalities.


Instruction: In what age group do S4.4.4.3-38 occur at higher rates than in lean and otherwise healthy children and adolescents?

Output: young adulthood

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what age group do S4.4.4.3-38 occur at higher rates than in lean and otherwise healthy children and adolescents?. ### Response: young adulthood.


Instruction: What does longitudinal cohort data show about cardiovascular risk factors from childhood to adulthood in the pediatric population?

Output: mod-erate tracking

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does longitudinal cohort data show about cardiovascular risk factors from childhood to adulthood in the pediatric population?. ### Response: mod-erate tracking.


Instruction: What is a potential benefit of identifying lipid disorders in childhood?

Output: persistence of the underlying pathophysiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a potential benefit of identifying lipid disorders in childhood?. ### Response: persistence of the underlying pathophysiology.


Instruction: What is recommended in Recommendation 1?

Output: Selective screening for lipid disorders on the basis of family history

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended in Recommendation 1?. ### Response: Selective screening for lipid disorders on the basis of family history.


Instruction: On the basis of family history and lifestyle-related factors, what is considered to identify a portion of childhood lipid abnormalities?

Output: Selective screening

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On the basis of family history and lifestyle-related factors, what is considered to identify a portion of childhood lipid abnormalities?. ### Response: Selective screening.


Instruction: What is the 2011 National Heart, Lung and Blood Institute Expert Panel on Integrated Guidelines Table 9?

Output: Normal and Abnormal Lipid Values in Childhood

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2011 National Heart, Lung and Blood Institute Expert Panel on Integrated Guidelines Table 9?. ### Response: Normal and Abnormal Lipid Values in Childhood.