Instruction: What group had lower protamine to heparin ratios than the ACT-based control group?

Output: heparin concen-tration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What group had lower protamine to heparin ratios than the ACT-based control group?. ### Response: heparin concen-tration.


Instruction: How many patients were scheduled for reoperation?

Output: 31

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were scheduled for reoperation?. ### Response: 31.


Instruction: What did another randomized trial of 31 patients result in?

Output: signi ﬁcantreductions in perioperative blood loss and blood productusage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did another randomized trial of 31 patients result in?. ### Response: signi ﬁcantreductions in perioperative blood loss and blood productusage.


Instruction: How many patients scheduled for reoperation resulted in signi ficantreductions in perioperative blood loss and blood productusage?

Output: 31

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients scheduled for reoperation resulted in signi ficantreductions in perioperative blood loss and blood productusage?. ### Response: 31.


Instruction: What did another study find reducedplatelet activation and evidence of reduced thrombingeneration with heparin concentration monitoring?

Output: routine ACT monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did another study find reducedplatelet activation and evidence of reduced thrombingeneration with heparin concentration monitoring?. ### Response: routine ACT monitoring.


Instruction: What was the June 2015 outcome among hypertensive patients with diabetes and coronary artery disease?

Output: Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the June 2015 outcome among hypertensive patients with diabetes and coronary artery disease?. ### Response: Hypertension.


Instruction: When was the JAMA 304:61-68?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the JAMA 304:61-68?. ### Response: 2010.


Instruction: What is the name of the journal that studies the relationship between hypertension and diabetes?

Output: JAMA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies the relationship between hypertension and diabetes?. ### Response: JAMA.


Instruction: What is the relationship between baseline systolic blood pressure and long-term outcomes in ambulatory patients with chronic mild to moder-ate heart failure?

Output: Relation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the relationship between baseline systolic blood pressure and long-term outcomes in ambulatory patients with chronic mild to moder-ate heart failure?. ### Response: Relation.


Instruction: What are the 2011 Am J Cardiol.107:1208-1214?

Output: 163

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the 2011 Am J Cardiol.107:1208-1214?. ### Response: 163.


Instruction: What is ONTARGET?

Output: Blood pres-sure targets recommended by guidelines and incidence of cardiovascular and renal events in the Ongoing Telmisartan Alone and in Combination With Ramipril Global Endpoint Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ONTARGET?. ### Response: Blood pres-sure targets recommended by guidelines and incidence of cardiovascular and renal events in the Ongoing Telmisartan Alone and in Combination With Ramipril Global Endpoint Trial.


Instruction: What are the blood pres-sure targets?

Output: Ongoing Telmisartan Alone and in Combination With Ramipril Global Endpoint Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the blood pres-sure targets?. ### Response: Ongoing Telmisartan Alone and in Combination With Ramipril Global Endpoint Trial.


Instruction: What does ONTARGET stand for?

Output: Ongoing Telmisartan Alone and in Combination With Ramipril Global Endpoint Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ONTARGET stand for?. ### Response: Ongoing Telmisartan Alone and in Combination With Ramipril Global Endpoint Trial.


Instruction: What is the name of the global endpoint trial?

Output: Ramipril

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the global endpoint trial?. ### Response: Ramipril.


Instruction: When was the Circulation. 2011;124:1727–1736.

Output: 164

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circulation. 2011;124:1727–1736.. ### Response: 164.


Instruction: What was the name given to the Global Endpoint Trial?

Output: Ramipril

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name given to the Global Endpoint Trial?. ### Response: Ramipril.


Instruction: What is the name of the ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial?

Output: ONTARGET

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial?. ### Response: ONTARGET.


Instruction: When was the J Am Coll Cardiol.59:74–83?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol.59:74–83?. ### Response: 2012.


Instruction: What did the Modification of Diet in Renal Disease Study Group achieve and safety of in chronic re-nal disease?

Output: low blood pressure goal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Modification of Diet in Renal Disease Study Group achieve and safety of in chronic re-nal disease?. ### Response: low blood pressure goal.


Instruction: Hypertension. 1997;29:641–650.

Output: 166

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hypertension. 1997;29:641–650.. ### Response: 166.


Instruction: What is the name of the study group that studies blood-pressure control for renoprotection in diabetic patients?

Output: REIN-2 Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study group that studies blood-pressure control for renoprotection in diabetic patients?. ### Response: REIN-2 Study Group.


Instruction: What is REIN-2?

Output: Blood-pressure control for renoprotection in pa-tients with non-diabetic chronic renal disease (REIN-2): multicentre, randomised controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is REIN-2?. ### Response: Blood-pressure control for renoprotection in pa-tients with non-diabetic chronic renal disease (REIN-2): multicentre, randomised controlled trial.


Instruction: What is the name of the multicentre, randomised controlled trial for renoprotection in pa-tients with non-diabetic chronic renal disease?

Output: REIN-2 Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multicentre, randomised controlled trial for renoprotection in pa-tients with non-diabetic chronic renal disease?. ### Response: REIN-2 Study Group.


Instruction: When was the Lancet 365:939-946?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Lancet 365:939-946?. ### Response: 2005.


Instruction: What is the 2013 ESH/ESC guidelines for the management of arterial hypertension?

Output: the Task Force

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2013 ESH/ESC guidelines for the management of arterial hypertension?. ### Response: the Task Force.


Instruction: What is the name of the Task Force for the management of arterial hypertension?

Output: European Society of Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force for the management of arterial hypertension?. ### Response: European Society of Hypertension.


Instruction: What is ESC?

Output: European Society of Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ESC?. ### Response: European Society of Cardiology.


Instruction: What is the name of the MA, Franklin BA, Gibbons RJ, Grundy SM, Hiratzka LF, Jones DW, Lloyd-Jones DM, Minissian M, Mosca L, Peterson ED, Sacco RL, Spertus J, Stein JH?

Output: Creager

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the MA, Franklin BA, Gibbons RJ, Grundy SM, Hiratzka LF, Jones DW, Lloyd-Jones DM, Minissian M, Mosca L, Peterson ED, Sacco RL, Spertus J, Stein JH?. ### Response: Creager.


Instruction: What should not be construed as randomized clinical trial evidence of benefit in this age group?

Output: Guideline for the Secondary Prevention of Ischemic Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not be construed as randomized clinical trial evidence of benefit in this age group?. ### Response: Guideline for the Secondary Prevention of Ischemic Stroke.


Instruction: What should rarely be performed?

Output: Guideline for the Secondary Prevention of Ischemic Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should rarely be performed?. ### Response: Guideline for the Secondary Prevention of Ischemic Stroke.


Instruction: What age group should PFO clo-sure rarely be performed in?

Output: older

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What age group should PFO clo-sure rarely be performed in?. ### Response: older.


Instruction: What is essential that a thorough evaluation has been completed and that there is no alternative cause of the stroke?

Output: clinical judgement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is essential that a thorough evaluation has been completed and that there is no alternative cause of the stroke?. ### Response: clinical judgement.


Instruction: How many studies showed benefit from PFO closure excluded lacunar strokes?

Output: 553–556

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies showed benefit from PFO closure excluded lacunar strokes?. ### Response: 553–556.


Instruction: The require-ment that the stroke be cryptogenic is equivalent to what?

Output: nonlacunar stroke of undetermined source, or ESUS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The require-ment that the stroke be cryptogenic is equivalent to what?. ### Response: nonlacunar stroke of undetermined source, or ESUS.


Instruction: What is required because many strokes in the ESUS category may not have a definite cause but other lower-competing-risk?

Output: clinical judgement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is required because many strokes in the ESUS category may not have a definite cause but other lower-competing-risk?. ### Response: clinical judgement.


Instruction: What type of artery disease has 40% stenosis?

Output: proximal large

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of artery disease has 40% stenosis?. ### Response: proximal large.


Instruction: What age group is more likely to have PFOs that are related to their stroke?

Output: younger

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What age group is more likely to have PFOs that are related to their stroke?. ### Response: younger.


Instruction: What does PFO stand for?

Output: Patent foramen ovale

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does PFO stand for?. ### Response: Patent foramen ovale.


Instruction: What is the PFO and ischemic stroke management guide?

Output: Patent foramen ovale

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the PFO and ischemic stroke management guide?. ### Response: Patent foramen ovale.


Instruction: CT indicates computed tomography; DVT indicates what?

Output: deep vein thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: CT indicates computed tomography; DVT indicates what?. ### Response: deep vein thrombosis.


Instruction: LP indicates what type of puncture?

Output: lumbar

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: LP indicates what type of puncture?. ### Response: lumbar.


Instruction: What is the acronym for vein thrombosis?

Output: DVT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for vein thrombosis?. ### Response: DVT.


Instruction: What is LP?

Output: lumbar puncture

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is LP?. ### Response: lumbar puncture.


Instruction: Where is TIA from?

Output: transient ischemic attack

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is TIA from?. ### Response: transient ischemic attack.


Instruction: What are some considerations in choosing anti-hypertensive drugs for use in adult kidney transplantrecipients?

Output: side effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some considerations in choosing anti-hypertensive drugs for use in adult kidney transplantrecipients?. ### Response: side effects.


Instruction: What are side effects that are also seen in the general population?

Output: increased propensity to hyperkalemia or anemiawith ACE-Is or ARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are side effects that are also seen in the general population?. ### Response: increased propensity to hyperkalemia or anemiawith ACE-Is or ARBs.


Instruction: ARBs), level of urine albumin, degree of hemodynamic stability and potential to altergraft perfusion?

Output: 294,295

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ARBs), level of urine albumin, degree of hemodynamic stability and potential to altergraft perfusion?. ### Response: 294,295.


Instruction: Co-morbid conditions that may indicate or preclude certain agents, interactions with immunosuppressive medica-tions or other medications unique to patients with kidneytransplant patients, and long-term impact on graft function,CVD, and what else?

Output: all-cause mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Co-morbid conditions that may indicate or preclude certain agents, interactions with immunosuppressive medica-tions or other medications unique to patients with kidneytransplant patients, and long-term impact on graft function,CVD, and what else?. ### Response: all-cause mortality.


Instruction: What is the long-term impact on graft function,CVD, and all-cause mortality?

Output: other medications unique to patients with kidneytransplant patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the long-term impact on graft function,CVD, and all-cause mortality?. ### Response: other medications unique to patients with kidneytransplant patients.


Instruction: Why is there marked variability in the prescription ofcardioprotective medications after transplantation?

Output: Because of these considera-tions and the absence of large trials with clinically importantoutcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is there marked variability in the prescription ofcardioprotective medications after transplantation?. ### Response: Because of these considera-tions and the absence of large trials with clinically importantoutcomes.


Instruction: What do short-term RCTs suggest?

Output: abeneﬁcial effect of calcium-channel blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do short-term RCTs suggest?. ### Response: abeneﬁcial effect of calcium-channel blockers.


Instruction: What did a recent meta-analysis of RCTs indicate about the use of calcium-channel blockers?

Output: abeneﬁcial effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a recent meta-analysis of RCTs indicate about the use of calcium-channel blockers?. ### Response: abeneﬁcial effect.


Instruction: What was associated with a 25% lower rate of kidney function?

Output: calcium-channel blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with a 25% lower rate of kidney function?. ### Response: calcium-channel blockers.


Instruction: What was associated with a 25% lower rate of graftloss?

Output: calcium-channel blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with a 25% lower rate of graftloss?. ### Response: calcium-channel blockers.


Instruction: What did the Canadian Society of Transplantation andCanadian Society of Nephrology question the 2009 KDIGO Clinical Practice Guideline for?

Output: the Care of Kidney Transplant Recipients to use any class ofantihypertensive agent after kidney transplantation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Canadian Society of Transplantation andCanadian Society of Nephrology question the 2009 KDIGO Clinical Practice Guideline for?. ### Response: the Care of Kidney Transplant Recipients to use any class ofantihypertensive agent after kidney transplantation.


Instruction: What is the recommen-dation from the 2009 KDIGO Clinical Practice Guideline for Care of Kidney Transplant Recipients?

Output: to use any class ofantihypertensive agent after kidney transplantation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommen-dation from the 2009 KDIGO Clinical Practice Guideline for Care of Kidney Transplant Recipients?. ### Response: to use any class ofantihypertensive agent after kidney transplantation.


Instruction: What do most transplantation centers prefer to use for initial therapy after transplan-tation?

Output: dihydropyridinecalcium-channel blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do most transplantation centers prefer to use for initial therapy after transplan-tation?. ### Response: dihydropyridinecalcium-channel blockers.


Instruction: What might non-dihydropy-ridines interfere with the metabolism and excretion of?

Output: chapter 5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What might non-dihydropy-ridines interfere with the metabolism and excretion of?. ### Response: chapter 5.


Instruction: What does ACEI mean?

Output: angiotensin-converting enzyme inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ACEI mean?. ### Response: angiotensin-converting enzyme inhibitor.


Instruction: What does ARB mean? What is the acronym for heart failure with reduced ejection fraction?

Output: angiotensin-receptor blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ARB mean? What is the acronym for heart failure with reduced ejection fraction?. ### Response: angiotensin-receptor blocker.


Instruction: What is the acronym for heart failure with reduced ejection fraction?

Output: HF rEF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for heart failure with reduced ejection fraction?. ### Response: HF rEF.


Instruction: What does LOE stand for?

Output: Level of Evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does LOE stand for?. ### Response: Level of Evidence.


Instruction: When was the last issue of JACC Vol. 62, No. 16?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last issue of JACC Vol. 62, No. 16?. ### Response: 2013.


Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al.


Instruction: What is the in-hospital mor -tality rate in patients with IE and HF treated with surgery?

Output: 21%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the in-hospital mor -tality rate in patients with IE and HF treated with surgery?. ### Response: 21%.


Instruction: How many baseline features have been independently associated with 6-month mortality in left-heart native valve endocarditis?

Output: 4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many baseline features have been independently associated with 6-month mortality in left-heart native valve endocarditis?. ### Response: 4.


Instruction: What is another name for Viridans streptococci?

Output: S. aureus, Staphylococcus aureus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for Viridans streptococci?. ### Response: S. aureus, Staphylococcus aureus.


Instruction: What is the risk of reinfection after prosthetic valve surgery?

Output: low

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of reinfection after prosthetic valve surgery?. ### Response: low.


Instruction: What are the indications for surgery for prosthetic valve endocarditis?

Output: hemodynamic and microbial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the indications for surgery for prosthetic valve endocarditis?. ### Response: hemodynamic and microbial.


Instruction: What is associated with higher mortality rates and higher post-treatment disability?

Output: Prosthetic valve endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with higher mortality rates and higher post-treatment disability?. ### Response: Prosthetic valve endocarditis.


Instruction: Surgical series report surgical rates of what?

Output: 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Surgical series report surgical rates of what?. ### Response: 50%.


Instruction: What percentage of prosthetic valve endocarditis patients show improved outcomes over medical therapy?

Output: 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of prosthetic valve endocarditis patients show improved outcomes over medical therapy?. ### Response: 50%.


Instruction: Patients with left-sided S. aureus IE were significantly more likely to die than patients with what other organism?

Output: IE attributable to other organisms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with left-sided S. aureus IE were significantly more likely to die than patients with what other organism?. ### Response: IE attributable to other organisms.


Instruction: What percentage of patients with S. aureus IE died?

Output: 20%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients with S. aureus IE died?. ### Response: 20%.


Instruction: What percent of patients had a central nervous sys-tem event?

Output: 20%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percent of patients had a central nervous sys-tem event?. ### Response: 20%.


Instruction: How much of a mortality rate has Staphylococcal pros-thetic valve endocarditis been associated with?

Output: 70%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of a mortality rate has Staphylococcal pros-thetic valve endocarditis been associated with?. ### Response: 70%,.


Instruction: What has been associated with a mortality rate as high as 70%?

Output: Staphylococcal pros-thetic valve endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been associated with a mortality rate as high as 70%?. ### Response: Staphylococcal pros-thetic valve endocarditis.


Instruction: What is driven by resistant staphylococcal species?

Output: endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is driven by resistant staphylococcal species?. ### Response: endocarditis.


Instruction: When is death occurs in 5% of patients with right-sided native valve?

Output: <5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is death occurs in 5% of patients with right-sided native valve?. ### Response: <5%.


Instruction: What is IE caused by?

Output: other organisms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is IE caused by?. ### Response: other organisms.


Instruction: What is early surgery defined as during initial hospital course and before completion of full course of appropriate antibiotics?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is early surgery defined as during initial hospital course and before completion of full course of appropriate antibiotics?. ### Response: †.


Instruction: What does DUA mean?

Output: drug use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does DUA mean?. ### Response: drug use.


Instruction: What does HF mean? What does ICD stand for?

Output: heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does HF mean? What does ICD stand for?. ### Response: heart failure.


Instruction: Infective endocarditis is what?

Output: IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Infective endocarditis is what?. ### Response: IE.


Instruction: What is NVE?

Output: native valve endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NVE?. ### Response: native valve endocarditis.


Instruction: What is OST?

Output: opioid substitution treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is OST?. ### Response: opioid substitution treatment.


Instruction: Where can you find the latest version of the article?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find the latest version of the article?. ### Response: http://ahajournals.org.


Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction?

Output: 2014 VA/DoD Dyslipidemia CPG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction?. ### Response: 2014 VA/DoD Dyslipidemia CPG.


Instruction: When was the EBPWG first chartered?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the EBPWG first chartered?. ### Response: 2004.


Instruction: When was the EBPWG chartered?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the EBPWG chartered?. ### Response: 2004.


Instruction: What is the mission of the Health Executive Committee (HEC)?

Output: …on the use of clinical and epide miological evidence to improve the health of the population

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the mission of the Health Executive Committee (HEC)?. ### Response: …on the use of clinical and epide miological evidence to improve the health of the population.


Instruction: What does MHS stand for?

Output: Military Health System

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does MHS stand for?. ### Response: Military Health System.


Instruction: What does a CPG do for the VA and DoD populations?

Output: facilitating the development of clinical practice guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does a CPG do for the VA and DoD populations?. ### Response: facilitating the development of clinical practice guidelines.


Instruction: In what year did the VA and DoD publish a CPG for the Management of Dyslipidemia for Cardiovascular Risk Reduction?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did the VA and DoD publish a CPG for the Management of Dyslipidemia for Cardiovascular Risk Reduction?. ### Response: 2014.


Instruction: In what year was a recommendation to update the 2014 VA/DoD Dyslipidemia CPG initiated?

Output: 201 9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was a recommendation to update the 2014 VA/DoD Dyslipidemia CPG initiated?. ### Response: 201 9.


Instruction: When was the VA/DoD Dyslipidemia CPG initiated?

Output: 201 9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the VA/DoD Dyslipidemia CPG initiated?. ### Response: 201 9.


Instruction: What is the system wide goal of evidence based guidelines?

Output: improve the patient’s health and well -being

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the system wide goal of evidence based guidelines?. ### Response: improve the patient’s health and well -being.


Instruction: What are the expected outcomes of successful implementation of this guideline?

Output: improved clinical outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the expected outcomes of successful implementation of this guideline?. ### Response: improved clinical outcomes.


Instruction: What is used in the use of patient centered care?

Output: risk factors and event history

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used in the use of patient centered care?. ### Response: risk factors and event history.


Instruction: Dyslipidemia is Defined by Risk for Cardiovascular Disease?

Output: Dyslipidemia is Defined by Risk for Cardiovascular Disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Dyslipidemia is Defined by Risk for Cardiovascular Disease?. ### Response: Dyslipidemia is Defined by Risk for Cardiovascular Disease.


Instruction: What is the goal of optimizing each individual’s health outcomes?

Output: improving quality of life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the goal of optimizing each individual’s health outcomes?. ### Response: improving quality of life.


Instruction: What is a major cause of morbidity and mortality in the U.S. and globally?

Output: Cardiovascular diseasea

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a major cause of morbidity and mortality in the U.S. and globally?. ### Response: Cardiovascular diseasea.


Instruction: What is the most common cause of CVD?

Output: atherosclerosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common cause of CVD?. ### Response: atherosclerosis.


Instruction: Atherosclerosis is the buildup of what?

Output: plaque

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atherosclerosis is the buildup of what?. ### Response: plaque.


Instruction: What type of plaque is found in the walls of the arteries?

Output: atherosclerosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of plaque is found in the walls of the arteries?. ### Response: atherosclerosis.


Instruction: What can narrow the lumen of arteries, limiting the flow of oxygenated blood and increasing the risk of chronic and acute ischemia?

Output: plaque

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can narrow the lumen of arteries, limiting the flow of oxygenated blood and increasing the risk of chronic and acute ischemia?. ### Response: plaque.


Instruction: If a plaque ruptures within a vital artery, what form?

Output: a blood clot

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: If a plaque ruptures within a vital artery, what form?. ### Response: a blood clot.


Instruction: What happens to a vital artery when a plaque ruptures?

Output: a blood clot forms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What happens to a vital artery when a plaque ruptures?. ### Response: a blood clot forms.


Instruction: What can result in an AC S, MI, or stroke?

Output: If a plaque ruptures within a vital artery, a blood clot forms and may obstruct the flow of oxygenated blood to the heart or brain

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can result in an AC S, MI, or stroke?. ### Response: If a plaque ruptures within a vital artery, a blood clot forms and may obstruct the flow of oxygenated blood to the heart or brain.


Instruction: How can a blood clot form?

Output: If a plaque ruptures within a vital artery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can a blood clot form?. ### Response: If a plaque ruptures within a vital artery.


Instruction: What are some of the risk factors for CVD?

Output: high cholesterol levels, elevated blood pressure, insulin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the risk factors for CVD?. ### Response: high cholesterol levels, elevated blood pressure, insulin.


Instruction: What is an example of a CVD risk factor?

Output: Dyslipidemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a CVD risk factor?. ### Response: Dyslipidemia.


Instruction: What is the name of the meta-analysis that found that fixed-dose combina-tions improve medication compliance?

Output: a meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis that found that fixed-dose combina-tions improve medication compliance?. ### Response: a meta-analysis.


Instruction: What are the names of the groups among participants with type 2 diabetes?

Output: 129

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the groups among participants with type 2 diabetes?. ### Response: 129.


Instruction: When was the Diabetes Res Clin Pract 98:83–90?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Diabetes Res Clin Pract 98:83–90?. ### Response: 2012.


Instruction: What is the difference between single pill and free combination antihypertensives?

Output: Evaluation of compliance and health care utilization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between single pill and free combination antihypertensives?. ### Response: Evaluation of compliance and health care utilization.


Instruction: What is a meta-analysis of fixed-dose combinations?

Output: Compliance, safety, and effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a meta-analysis of fixed-dose combinations?. ### Response: Compliance, safety, and effectiveness.


Instruction: What is a meta-analysis of health care costs and adherence?

Output: Single-pill vs free-equivalent combi-nation therapies for hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a meta-analysis of health care costs and adherence?. ### Response: Single-pill vs free-equivalent combi-nation therapies for hypertension.


Instruction: What is the name of the journal that studies the costs of single-pill vs free-equivalent combi-nation therapies for hypertension?

Output: J Clin Hypertens

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies the costs of single-pill vs free-equivalent combi-nation therapies for hypertension?. ### Response: J Clin Hypertens.


Instruction: What is the name of the panel that evaluated blood pressure in adults in clinical practice and clinic-based research?

Output: JACC Scientific Expert Panel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the panel that evaluated blood pressure in adults in clinical practice and clinic-based research?. ### Response: JACC Scientific Expert Panel.


Instruction: When did JACC Scientific Expert Panel review blood pressure assessment in adults?

Output: 2019

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did JACC Scientific Expert Panel review blood pressure assessment in adults?. ### Response: 2019.


Instruction: What did Roerecke M, Kaczorowski J, Myers MG compare automated office blood pressure readings with?

Output: other methods of blood pressure measure-ment for identifying patients with possible hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Roerecke M, Kaczorowski J, Myers MG compare automated office blood pressure readings with?. ### Response: other methods of blood pressure measure-ment for identifying patients with possible hypertension.


Instruction: What is blood pressure measure-ment for identifying patients with possible hypertension?

Output: automated office blood pressure readings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is blood pressure measure-ment for identifying patients with possible hypertension?. ### Response: automated office blood pressure readings.


Instruction: When was the systematic review and meta-analysis published?

Output: Feb 4, 2019

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the systematic review and meta-analysis published?. ### Response: Feb 4, 2019.


Instruction: What is the DOI: 10.1001/jamainternmed.2018.6551?

Output: JAMA Intern Med

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the DOI: 10.1001/jamainternmed.2018.6551?. ### Response: JAMA Intern Med.


Instruction: What is the Task force for the Management of Arterial Hypertension?

Output: ESH/ESC guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Task force for the Management of Arterial Hypertension?. ### Response: ESH/ESC guidelines.


Instruction: What does ESH stand for?

Output: European Society of Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ESH stand for?. ### Response: European Society of Hypertension.


Instruction: What is stethoscope bell and diaphragm used for in the measurement of blood pressure?

Output: clinical blood pressure measurement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is stethoscope bell and diaphragm used for in the measurement of blood pressure?. ### Response: clinical blood pressure measurement.


Instruction: What is the name of the quiz in the 2014 Ann Intern Med?

Output: ITC6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the quiz in the 2014 Ann Intern Med?. ### Response: ITC6.


Instruction: When was the J Hypertens. 23:499–503?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Hypertens. 23:499–503?. ### Response: 2005.


Instruction: What is bell and diaphragm used for?

Output: clinical blood pressure measurement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is bell and diaphragm used for?. ### Response: clinical blood pressure measurement.


Instruction: What is stethoscope tube length used for for clinical blood pressure measurement?

Output: Bell or diaphragm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is stethoscope tube length used for for clinical blood pressure measurement?. ### Response: Bell or diaphragm.


Instruction: When did Blood Press Monit. 2016:21:178–83?

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Blood Press Monit. 2016:21:178–83?. ### Response: 2016.


Instruction: Where can you find ASCVD Risk Predictor Plus?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find ASCVD Risk Predictor Plus?. ### Response: http://tools.acc.org.


Instruction: What is the name of the website that provides information on the ASCVDRiskCalculator?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the website that provides information on the ASCVDRiskCalculator?. ### Response: https://professional.heart.org.


Instruction: When was the ACVD-Risk Calculator last updated?

Output: July 15, 2019

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the ACVD-Risk Calculator last updated?. ### Response: July 15, 2019.


Instruction: What are the names of the organizations that provide information on cardiovascular disease?

Output: American College of Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the organizations that provide information on cardiovascular disease?. ### Response: American College of Cardiology.


Instruction: What is the time window between discharge and 40 days?

Output: the time point after which ICD therapy is currently recommended

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the time window between discharge and 40 days?. ### Response: the time point after which ICD therapy is currently recommended.


Instruction: What does treatment decisions rely almost exclusively on?

Output: parameters of LV systolic function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does treatment decisions rely almost exclusively on?. ### Response: parameters of LV systolic function.


Instruction: What is currently recommended after discharge?

Output: ICD therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is currently recommended after discharge?. ### Response: ICD therapy.


Instruction: Improved prediction rules and validated treatment rec-ommendations are urgently needed.

Output: 646

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Improved prediction rules and validated treatment rec-ommendations are urgently needed.. ### Response: 646.


Instruction: What is one area where there is room for improvement?

Output: timeliness of reperfusion and initiation of ACE inhib-itor/ARB therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one area where there is room for improvement?. ### Response: timeliness of reperfusion and initiation of ACE inhib-itor/ARB therapy.


Instruction: What adds further to the risks of HF and death?

Output: The superimposition of ischemic mitral regurgitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What adds further to the risks of HF and death?. ### Response: The superimposition of ischemic mitral regurgitation.


Instruction: What is encouraged after STEMI?

Output: exploration of the roles of cell- and gene-based therapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is encouraged after STEMI?. ### Response: exploration of the roles of cell- and gene-based therapies.


Instruction: Who is the President of the American College of Cardiology Foundation?

Output: William A. Zoghbi

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the President of the American College of Cardiology Foundation?. ### Response: William A. Zoghbi.


Instruction: What is the name of the senior vice president of science and quality?

Output: William J. Oetgen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the senior vice president of science and quality?. ### Response: William J. Oetgen.


Instruction: Who is the Senior Director of Science and Clinical Policy at the American College of Cardiology Foundation/American Heart Association?

Output: Charlene L. May

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Senior Director of Science and Clinical Policy at the American College of Cardiology Foundation/American Heart Association?. ### Response: Charlene L. May.


Instruction: What is the title of the Associate Director of Evidence-Based Medicine?

Output: Debjani Mukherjee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of the Associate Director of Evidence-Based Medicine?. ### Response: Debjani Mukherjee.


Instruction: Who is the Chief Executive Officer of the Office of Science Operations?

Output: Rose Marie Robertson

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Chief Executive Officer of the Office of Science Operations?. ### Response: Rose Marie Robertson.


Instruction: What is the title of the Chief Science Officer?

Output: Gayle R

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of the Chief Science Officer?. ### Response: Gayle R.


Instruction: Who is the Production Manager, Scientific Publications, Office of Science Operations?

Output: Jody Hundley

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Production Manager, Scientific Publications, Office of Science Operations?. ### Response: Jody Hundley.


Instruction: What is the name of the Task Force on Practice Guidelines?

Output: ACCF/AHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Practice Guidelines?. ### Response: ACCF/AHA.


Instruction: When was the Manual for ACCF/AHA Guideline Writing Committees published?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Manual for ACCF/AHA Guideline Writing Committees published?. ### Response: 2006.


Instruction: What year was the Heart Association's Manual for Writing Committees released?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the Heart Association's Manual for Writing Committees released?. ### Response: 2006.


Instruction: When was the Manual available?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Manual available?. ### Response: 2006.


Instruction: What is the name of the Committee on Standards for Systematic Reviews?

Output: Comparative Effectiveness Research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Committee on Standards for Systematic Reviews?. ### Response: Comparative Effectiveness Research.


Instruction: Care: Standards for Systematic Reviews. Washington, DC: The National Academies Press.

Output: Finding What Works in Health Care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Care: Standards for Systematic Reviews. Washington, DC: The National Academies Press.. ### Response: Finding What Works in Health Care.


Instruction: What is the VA/DoD Clinical Practice Guideline for the Diagnosis and Management of Hypertension in the Primary Care Setting March 2020?

Output: Page 43 of 134

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for the Diagnosis and Management of Hypertension in the Primary Care Setting March 2020?. ### Response: Page 43 of 134.


Instruction: What was grouped based on whether the nutrition intervention was delivered by a registered dietitian versus other practitioners?

Output: studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was grouped based on whether the nutrition intervention was delivered by a registered dietitian versus other practitioners?. ### Response: studies.


Instruction: What did the registered dietitian -led nutrition intervention group only see significant reductions in?

Output: SBP (MD - 3.5 mm Hg) and DBP (MD -1.37 mm Hg)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the registered dietitian -led nutrition intervention group only see significant reductions in?. ### Response: SBP (MD - 3.5 mm Hg) and DBP (MD -1.37 mm Hg).


Instruction: What was more pronounced with interventions longer than six months?

Output: blood pressure reductions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was more pronounced with interventions longer than six months?. ### Response: blood pressure reductions.


Instruction: No significant harms were found in what group?

Output: nutrition interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No significant harms were found in what group?. ### Response: nutrition interventions.


Instruction: How long did nutrition interventions last?

Output: six  months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did nutrition interventions last?. ### Response: six  months.


Instruction: What did patients and caregivers strongly value dietary interventions to lower?

Output: blood pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did patients and caregivers strongly value dietary interventions to lower?. ### Response: blood pressure.


Instruction: What can a comprehensive dietitian-led intervention positively impact other aspects of cardiovascular health?

Output: blood lipid and glucose levels, weight loss , and alcohol cessation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can a comprehensive dietitian-led intervention positively impact other aspects of cardiovascular health?. ### Response: blood lipid and glucose levels, weight loss , and alcohol cessation.


Instruction: What may be barriers in obtaining healthy food choices for some patients?

Output: small size, inadequate allocation concealment and blinding, and inclusion of dietary approach as a part of multidisciplinary intervention in some individual studies . Other considerations regarding this recommendation included patients’ preferences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be barriers in obtaining healthy food choices for some patients?. ### Response: small size, inadequate allocation concealment and blinding, and inclusion of dietary approach as a part of multidisciplinary intervention in some individual studies . Other considerations regarding this recommendation included patients’ preferences.


Instruction: Service Members often do not get what?

Output: a choice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Service Members often do not get what?. ### Response: a choice.


Instruction: What does MRE stand for?

Output: Meals Ready to Eat

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does MRE stand for?. ### Response: Meals Ready to Eat.


Instruction: What is a food source that may vary?

Output: sodium and fat

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a food source that may vary?. ### Response: sodium and fat.


Instruction: What does FOB stand for?

Output: forward operating base

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does FOB stand for?. ### Response: forward operating base.


Instruction: What is COB also known as?

Output: central operating b ase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is COB also known as?. ### Response: central operating b ase.


Instruction: Depending on what area of responsibility the Service Member is deployed to, what may be high in?

Output: sodium and fat

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Depending on what area of responsibility the Service Member is deployed to, what may be high in?. ### Response: sodium and fat.


Instruction: What may impact HTN management and necessitate counseling related to diet?

Output: nutritional factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may impact HTN management and necessitate counseling related to diet?. ### Response: nutritional factors.


Instruction: The Work Group systematically reviewed the relevant evidence identified in the evidence review conducted as part of what?

Output: this guideline update

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The Work Group systematically reviewed the relevant evidence identified in the evidence review conducted as part of what?. ### Response: this guideline update.


Instruction: What is the Work Group's confidence in the quality of the evidence low?

Output: The body of evidence showed overall modest effect size

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Work Group's confidence in the quality of the evidence low?. ### Response: The body of evidence showed overall modest effect size.


Instruction: What limitations did the body of evidence have?

Output: small size, inadequate allocation concealment and blinding, and inclusion of dietary approach as a part of multidisciplinary intervention in some individual studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What limitations did the body of evidence have?. ### Response: small size, inadequate allocation concealment and blinding, and inclusion of dietary approach as a part of multidisciplinary intervention in some individual studies.


Instruction: What was included as a part of multidisciplinary intervention in some individual studies?

Output: dietary approach

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was included as a part of multidisciplinary intervention in some individual studies?. ### Response: dietary approach.


Instruction: What were other considerations regarding this recommendation?

Output: patients’ preferences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were other considerations regarding this recommendation?. ### Response: patients’ preferences.


Instruction: The potential benefit of nutritional intervention to improve global cardiovascular health outweighs what?

Output: potential adverse events and burden

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The potential benefit of nutritional intervention to improve global cardiovascular health outweighs what?. ### Response: potential adverse events and burden.


Instruction: What did the Work Group decide upon?

Output: a “Weak for” recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Work Group decide upon?. ### Response: a “Weak for” recommendation.


Instruction: What was a weak for recommendation?

Output: nutritional intervention to improve global cardiovascular health

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a weak for recommendation?. ### Response: nutritional intervention to improve global cardiovascular health.


Instruction: How much research is needed to evaluate intensity and duration of dietitian-led interventions?

Output: More

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much research is needed to evaluate intensity and duration of dietitian-led interventions?. ### Response: More.


Instruction: What type of intervention can be used to manage HTN in specific subgroups?

Output: multidisciplinary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of intervention can be used to manage HTN in specific subgroups?. ### Response: multidisciplinary.


Instruction: What do we suggest for technology based interventions?

Output: e -counseling, electronic transmission of data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do we suggest for technology based interventions?. ### Response: e -counseling, electronic transmission of data.


Instruction: What is the difference between intensive versus conventional glucosecontrol in critically ill patients?

Output: important risk marker of mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between intensive versus conventional glucosecontrol in critically ill patients?. ### Response: important risk marker of mortality.


Instruction: What was the N Engl J Med. 2009;360:1283–97.150?

Output: Intensive versus conventional glucosecontrol in critically ill patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the N Engl J Med. 2009;360:1283–97.150?. ### Response: Intensive versus conventional glucosecontrol in critically ill patients.


Instruction: Who was the spontaneous and iatrogenic hypoglycemia and mortality in?

Output: patients hospi-talized with acute myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the spontaneous and iatrogenic hypoglycemia and mortality in?. ### Response: patients hospi-talized with acute myocardial infarction.


Instruction: What is a risk marker of mortality in conventionally treatedpatients with diabetes mellitus and acute myocardial infarction?

Output: Glycometabolic state atadmission

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk marker of mortality in conventionally treatedpatients with diabetes mellitus and acute myocardial infarction?. ### Response: Glycometabolic state atadmission.


Instruction: What is the name of the DIGAMI study?

Output: Diabetes and Insulin-Glucose Infusion in Acute MyocardialInfarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the DIGAMI study?. ### Response: Diabetes and Insulin-Glucose Infusion in Acute MyocardialInfarction.


Instruction: What is DIGAMI?

Output: Diabetes and Insulin-Glucose Infusion in Acute MyocardialInfarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is DIGAMI?. ### Response: Diabetes and Insulin-Glucose Infusion in Acute MyocardialInfarction.


Instruction: What is ACC/AHA guidelines for management of patients with ST-elevation myocardial infarction?

Output: areport of the American College of Cardiology/American Heart Asso-ciation Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ACC/AHA guidelines for management of patients with ST-elevation myocardial infarction?. ### Response: areport of the American College of Cardiology/American Heart Asso-ciation Task Force on Practice Guidelines.


Instruction: What is the name of the Task Force on Practice Guidelines?

Output: American College of Cardiology Foundation/American Heart Asso-ciation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Practice Guidelines?. ### Response: American College of Cardiology Foundation/American Heart Asso-ciation.


Instruction: When were the 1999 Guidelines for the Management of Patients with Acute MyocardialInfarction Revised?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When were the 1999 Guidelines for the Management of Patients with Acute MyocardialInfarction Revised?. ### Response: 2004.


Instruction: What are the ACC/AHA/SCAI guidelines for the management of?

Output: patients with ST-elevation myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the ACC/AHA/SCAI guidelines for the management of?. ### Response: patients with ST-elevation myocardial infarction.


Instruction: What is the acronym for the American College of Cardiology Foundation/American Heart Association Task Force?

Output: American Heart Asso-ciation Task Force

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the American College of Cardiology Foundation/American Heart Association Task Force?. ### Response: American Heart Asso-ciation Task Force.


Instruction: What is the acronym for the American College of Cardiology Foundation/American Heart Asso-ciation Task Force on Practice Guidelines?

Output: Committee to Revise the1999 Guidelines for the Management of Patients with Acute MyocardialInfarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the American College of Cardiology Foundation/American Heart Asso-ciation Task Force on Practice Guidelines?. ### Response: Committee to Revise the1999 Guidelines for the Management of Patients with Acute MyocardialInfarction.


Instruction: When was the Circulation.120:2271–306.155 published?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circulation.120:2271–306.155 published?. ### Response: 2009.


Instruction: What is a meta-analysis of benefits and risks of tight glucosecontrol in critically ill adults?

Output: JAMA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a meta-analysis of benefits and risks of tight glucosecontrol in critically ill adults?. ### Response: JAMA.


Instruction: What is the time dependence of plateletinhibition after a 600-mg loading dose of clopidogrel in a large, unselectable cohort of candidates for percutaneous coronary intervention?

Output: Time dependence of plateletinhibition after a 600-mg loading dose of clopidogrel in a large, unse-lected cohort of candidates for percutaneous coronary intervention. Cir-culation. 2005;111:2560–4.157

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the time dependence of plateletinhibition after a 600-mg loading dose of clopidogrel in a large, unselectable cohort of candidates for percutaneous coronary intervention?. ### Response: Time dependence of plateletinhibition after a 600-mg loading dose of clopidogrel in a large, unse-lected cohort of candidates for percutaneous coronary intervention. Cir-culation. 2005;111:2560–4.157.


Instruction: Circulation. 2005;111:2560–4.157.

Output: Cir-culation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation. 2005;111:2560–4.157.. ### Response: Cir-culation.


Instruction: What does the American Association of Clinical Endocrinologists and American Diabetes Association consensusstatement on?

Output: inpatient glycemic control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the American Association of Clinical Endocrinologists and American Diabetes Association consensusstatement on?. ### Response: inpatient glycemic control.


Instruction: What is the American Diabetes Association consensus statement on inpatient glycemic control?

Output: American Association ofClinical Endocrinologists and American Diabetes Association consensusstatement on inpatient glycemic control. Diabetes Care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the American Diabetes Association consensus statement on inpatient glycemic control?. ### Response: American Association ofClinical Endocrinologists and American Diabetes Association consensusstatement on inpatient glycemic control. Diabetes Care.


Instruction: What reduces heart inflammation and remodeling during acute myocardialinfarction?

Output: Tight glycemic control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What reduces heart inflammation and remodeling during acute myocardialinfarction?. ### Response: Tight glycemic control.


Instruction: What is a scientific statement from the American HeartAssociation Diabetes Committee of the Council on Nutrition, Physicalactivity, and Metabolism?

Output: Hyperglycemia and acutecoronary syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a scientific statement from the American HeartAssociation Diabetes Committee of the Council on Nutrition, Physicalactivity, and Metabolism?. ### Response: Hyperglycemia and acutecoronary syndrome.


Instruction: What is the name of the scientific statement?

Output: American HeartAssociation Diabetes Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the scientific statement?. ### Response: American HeartAssociation Diabetes Committee.


Instruction: What is BNP stable in a blood sample for 4 -6 hours?

Output: NT -proBNP is stable for days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is BNP stable in a blood sample for 4 -6 hours?. ### Response: NT -proBNP is stable for days.


Instruction: What is NT -proBNP stable for days?

Output: blood sample

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NT -proBNP stable for days?. ### Response: blood sample.


Instruction: In order to address the stability issue, what can BNP be used?

Output: different sample tubes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In order to address the stability issue, what can BNP be used?. ### Response: different sample tubes.


Instruction: What is another name for fluoride-citrate?

Output: EDTA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for fluoride-citrate?. ### Response: EDTA.


Instruction: How can BNP be collected in different sample tubes?

Output: In order to address the stability issue

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can BNP be collected in different sample tubes?. ### Response: In order to address the stability issue.


Instruction: What makes the process more complex and open to error?

Output: BNP can be collected in different sample tubes (EDTA or fluoride -citrate); however  this often requires more blood samples to be taken

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What makes the process more complex and open to error?. ### Response: BNP can be collected in different sample tubes (EDTA or fluoride -citrate); however  this often requires more blood samples to be taken.


Instruction: What can be collected in a standard serum tube with the rest of the sample?

Output: Samples for NT -proBNP testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be collected in a standard serum tube with the rest of the sample?. ### Response: Samples for NT -proBNP testing.


Instruction: What is more resource intensive?

Output: BNP can be collected in different sample tubes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more resource intensive?. ### Response: BNP can be collected in different sample tubes.


Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al.


Instruction: What is the DOI for the February 2, 2021 e125?

Output: 10.1161/CIR.0000000000000923

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the DOI for the February 2, 2021 e125?. ### Response: 10.1161/CIR.0000000000000923.


Instruction: Why is a higher cutoff for “nor-mal” LVEF used?

Output: Because the loading condi-tions in MR allow continued late ejection into a lower-impedance LA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is a higher cutoff for “nor-mal” LVEF used?. ### Response: Because the loading condi-tions in MR allow continued late ejection into a lower-impedance LA.


Instruction: What is used in MR than in other types of heart disease?

Output: mitral regurgitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used in MR than in other types of heart disease?. ### Response: mitral regurgitation.


Instruction: What is clearly inadvisable to allow patients’ LV function to deteriorate beyond the benchmarks of an LVEF 60% or LVESD 40mm?

Output: mitral valve repair

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is clearly inadvisable to allow patients’ LV function to deteriorate beyond the benchmarks of an LVEF 60% or LVESD 40mm?. ### Response: mitral valve repair.


Instruction: What is a principle guiding surgical referral?

Output: Repair success increases with surgical volume and expertise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a principle guiding surgical referral?. ### Response: Repair success increases with surgical volume and expertise.


Instruction: What is preferable to a poor repair?

Output: mitral valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is preferable to a poor repair?. ### Response: mitral valve replacement.


Instruction: When leaflet dysfunction is limited to only annuloplasty and repair of the pos-terior leaflet, what is the operative mortality rate?

Output: <1%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When leaflet dysfunction is limited to only annuloplasty and repair of the pos-terior leaflet, what is the operative mortality rate?. ### Response: <1%,.


Instruction: What is the result of a mini-mally invasive approach?

Output: similar to those of a full median sternotomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the result of a mini-mally invasive approach?. ### Response: similar to those of a full median sternotomy.


Instruction: What is an operative mortality rate of 1%?

Output: <1%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an operative mortality rate of 1%?. ### Response: <1%,.


Instruction: What is the long-term survival rate equivalent to that of the age-matched general population?

Output: <1%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the long-term survival rate equivalent to that of the age-matched general population?. ### Response: <1%,.


Instruction: How much freedom from reoperation is expected after 15 to 20 years after operation?

Output: 95%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much freedom from reoperation is expected after 15 to 20 years after operation?. ### Response: 95%.


Instruction: How many years after surgery are expected?

Output: 15 to 20

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many years after surgery are expected?. ### Response: 15 to 20.


Instruction: The onset of symptoms, LV dysfunction, or pulmonary hypertension worsens the prognosis for what?

Output: MR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The onset of symptoms, LV dysfunction, or pulmonary hypertension worsens the prognosis for what?. ### Response: MR.


Instruction: Careful surveillance may result in timing of valve surgery before what happens?

Output: negative sequelae

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Careful surveillance may result in timing of valve surgery before what happens?. ### Response: negative sequelae.


Instruction: What is an attractive alternative strategy for treating severe chronic primary MR?

Output: mitral valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an attractive alternative strategy for treating severe chronic primary MR?. ### Response: mitral valve replacement.


Instruction: What is one way to treat severe chronic primary MR?

Output: perform early mitral repair

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one way to treat severe chronic primary MR?. ### Response: perform early mitral repair.


Instruction: What prevents the need for intensive surveillance?

Output: Early mitral repair

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What prevents the need for intensive surveillance?. ### Response: Early mitral repair.


Instruction: How can patients become lost to follow-up?

Output: Early mitral repair

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can patients become lost to follow-up?. ### Response: Early mitral repair.


Instruction: What must be provided for the early mitral repair strat-egy to be effective?

Output: a durable repair

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must be provided for the early mitral repair strat-egy to be effective?. ### Response: a durable repair.


Instruction: An unwanted valve replacement and its attendant risks could be a complication of what?

Output: Figure 8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: An unwanted valve replacement and its attendant risks could be a complication of what?. ### Response: Figure 8.


Instruction: What is a complication of Figure 8?

Output: An unwanted valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a complication of Figure 8?. ### Response: An unwanted valve replacement.


Instruction: What corresponds to Table 2?

Output: Primary MR.Colors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What corresponds to Table 2?. ### Response: Primary MR.Colors.


Instruction: CVC indicates Com-prehensive Valve Center; ERO, effective regurgitant orifice; ESD, what?

Output: end-systolic dimension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: CVC indicates Com-prehensive Valve Center; ERO, effective regurgitant orifice; ESD, what?. ### Response: end-systolic dimension.


Instruction: Dimension; LVEF; ejection fraction; MR; MV; mitral valve replacement; RF; regurgitant fraction; RVol; and VC, vena contracta.

Output: 10.1161/CIR.0000000000000923 February 2, 2021 e125CLINICAL STATEMENTS  AND GUIDELINESstill worse prognosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Dimension; LVEF; ejection fraction; MR; MV; mitral valve replacement; RF; regurgitant fraction; RVol; and VC, vena contracta.. ### Response: 10.1161/CIR.0000000000000923 February 2, 2021 e125CLINICAL STATEMENTS  AND GUIDELINESstill worse prognosis.


Instruction: Who are the co-chairs of KDIGO?

Output: Michel Jadoul and Wolfgang C. Winkelmayer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who are the co-chairs of KDIGO?. ### Response: Michel Jadoul and Wolfgang C. Winkelmayer.


Instruction: Who is the immediate past Co-Chair of ERT?

Output: David C. Wheeler

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the immediate past Co-Chair of ERT?. ### Response: David C. Wheeler.


Instruction: Jonathan Craig, Martin Howell, David Tunnicliffe, and the ERT members contributed to what?

Output: the rigorous assessment of the available evi-dence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Jonathan Craig, Martin Howell, David Tunnicliffe, and the ERT members contributed to what?. ### Response: the rigorous assessment of the available evi-dence.


Instruction: Who contributed to the rigorous assessment of the available evi-dence?

Output: Jonathan Craig, Martin Howell, DavidTunnicliffe, and the ERT members

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who contributed to the rigorous assessment of the available evi-dence?. ### Response: Jonathan Craig, Martin Howell, DavidTunnicliffe, and the ERT members.


Instruction: How did Marcello Tonelli and Lyubov Lytvyn help strengthen the linkage between therecommendations and the evidence base?

Output: their guidance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Marcello Tonelli and Lyubov Lytvyn help strengthen the linkage between therecommendations and the evidence base?. ### Response: their guidance.


Instruction: What is KDIGO's aspiration for aliving guideline?

Output: a“living guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is KDIGO's aspiration for aliving guideline?. ### Response: a“living guideline.


Instruction: What did Debbie Maizels contribute to the artwork presented in the guide?

Output: vitalcontributions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Debbie Maizels contribute to the artwork presented in the guide?. ### Response: vitalcontributions.


Instruction: Joseph T. Flynn contributed to what chapter?

Output: Chapter 5: Blood pressure management in children with CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Joseph T. Flynn contributed to what chapter?. ### Response: Chapter 5: Blood pressure management in children with CKD.


Instruction: Who contributed to Chapter 5: Blood pressure management in children with CKD?

Output: Joseph T. Flynn

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who contributed to Chapter 5: Blood pressure management in children with CKD?. ### Response: Joseph T. Flynn.


Instruction: What did Joseph T. Flynn contribute to?

Output: Chapter 5: Blood pressure management in children with CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Joseph T. Flynn contribute to?. ### Response: Chapter 5: Blood pressure management in children with CKD.


Instruction: Who helped make the publication of this guideline possible?

Output: Work Group members

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who helped make the publication of this guideline possible?. ### Response: Work Group members.


Instruction: What kind of reviewers did the Work Group consider the guideline?

Output: public externalreviewers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What kind of reviewers did the Work Group consider the guideline?. ### Response: public externalreviewers.


Instruction: Who provided feedback during the public review of the draft guideline?

Output: Baris Afsar, Ahmed Akl

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who provided feedback during the public review of the draft guideline?. ### Response: Baris Afsar, Ahmed Akl.


Instruction: What did the Work Group consider all of the valuable comments made?

Output: suggested changeswere incorporated into the ﬁnal publication

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Work Group consider all of the valuable comments made?. ### Response: suggested changeswere incorporated into the ﬁnal publication.


Instruction: Who is the founder of the British and IrishHypertension Society?

Output: Lawrence Byrd

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the founder of the British and IrishHypertension Society?. ### Response: Lawrence Byrd.


Instruction: What is the name of the person who is a member of the B&IHYPERTENTION society?

Output: Lawrence Byrd

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the person who is a member of the B&IHYPERTENTION society?. ### Response: Lawrence Byrd.


Instruction: Who is an alumnus of the british and irishhypertension society?

Output: Lawrence Byrd

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is an alumnus of the british and irishhypertension society?. ### Response: Lawrence Byrd.


Instruction: What is the name of the person who wrote this article?

Output: Lawrence Byrd

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the person who wrote this article?. ### Response: Lawrence Byrd.


Instruction: Who is the author of this piece of writing?

Output: Pablo Amair

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of this piece of writing?. ### Response: Pablo Amair.


Instruction: What is one of the names of the people that wrote this piece?

Output: Lawrence Byrd

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the names of the people that wrote this piece?. ### Response: Lawrence Byrd.


Instruction: What is the name of the person who is known as Khwaja?

Output: Arif

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the person who is known as Khwaja?. ### Response: Arif.


Instruction: Who is the author of the book, Partha Pratim Mandal?

Output: Mallamaci

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of the book, Partha Pratim Mandal?. ### Response: Mallamaci.


Instruction: Which author is known for his work, MehranRaghib Motlagh?

Output: Sandro Mazzaferro

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which author is known for his work, MehranRaghib Motlagh?. ### Response: Sandro Mazzaferro.


Instruction: What is the name of the person who was a part of the team that was in charge of the project?

Output: David C. Wheeler

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the person who was a part of the team that was in charge of the project?. ### Response: David C. Wheeler.


Instruction: Who was the leader of the group that was involved in the project that was based in Mexico City?

Output: David C. Wheeler

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the leader of the group that was involved in the project that was based in Mexico City?. ### Response: David C. Wheeler.


Instruction: What was the name given to the person that was responsible for the project called?

Output: David C. Wheeler

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name given to the person that was responsible for the project called?. ### Response: David C. Wheeler.


Instruction: Which person was involved with the project named after?

Output: David C. Wheeler

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which person was involved with the project named after?. ### Response: David C. Wheeler.


Instruction: Stable angina: management (CG126) NICE 2022. All right s reserved.

Output: contr ol in managing t heir condition

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Stable angina: management (CG126) NICE 2022. All right s reserved.. ### Response: contr ol in managing t heir condition.


Instruction: What is the last updat ed 25 August 2016?

Output: Page 2 4of 26

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the last updat ed 25 August 2016?. ### Response: Page 2 4of 26.


Instruction: What does ACS stand for?

Output: acute coronary syndromes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ACS stand for?. ### Response: acute coronary syndromes.


Instruction: What is DSMB?

Output: data safety monitoring board

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is DSMB?. ### Response: data safety monitoring board.


Instruction: Where can ahajournals.org be found?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can ahajournals.org be found?. ### Response: http://ahajournals.org.


Instruction: What is recommended in patients with HF rEF with fluid retention?

Output: DiureticsDiuretics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended in patients with HF rEF with fluid retention?. ### Response: DiureticsDiuretics.


Instruction: What are the recommended drugs for all patients?

Output: ACE inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the recommended drugs for all patients?. ### Response: ACE inhibitors.


Instruction: Who is recommended for pharmacological therapy?

Output: Management of Stage C HF rEF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is recommended for pharmacological therapy?. ### Response: Management of Stage C HF rEF.


Instruction: What type of therapy is recommended for patients with HF rEF who are ACE inhibitor intolerant?

Output: ACE inhibitors are recommended for all patients with HF rEF IA 134,167–169ARBsARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is recommended for patients with HF rEF who are ACE inhibitor intolerant?. ### Response: ACE inhibitors are recommended for all patients with HF rEF IA 134,167–169ARBsARBs.


Instruction: What kind of therapy are ARBs reasonable as alternatives to?

Output: ACE inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What kind of therapy are ARBs reasonable as alternatives to?. ### Response: ACE inhibitors.