Instruction: What is the next step?

Output: Symptomatic subsegmentalpulmonary embolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the next step?. ### Response: Symptomatic subsegmentalpulmonary embolism.


Instruction: What is J Thromb Haemost.2012;10(8):1486-1490.111?

Output: Symptomatic subsegmentalpulmonary embolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is J Thromb Haemost.2012;10(8):1486-1490.111?. ### Response: Symptomatic subsegmentalpulmonary embolism.


Instruction: Stein PD, Goodman LR, Hull RD, Dalen JE, Matta F. Diagnosis andmanagement of what?

Output: isolated subsegmental pulmonary embolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Stein PD, Goodman LR, Hull RD, Dalen JE, Matta F. Diagnosis andmanagement of what?. ### Response: isolated subsegmental pulmonary embolism.


Instruction: What is interobserveragreement in the interpretation of computed tomography in acutepulmonary embolism?

Output: Prospective multicenter assessment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is interobserveragreement in the interpretation of computed tomography in acutepulmonary embolism?. ### Response: Prospective multicenter assessment.


Instruction: What is a cross-sectional analysis using expertopinion as reference standard?

Output: Concerns in usingmulti-detector computed tomography for diagnosing pulmonaryembolism in daily practice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a cross-sectional analysis using expertopinion as reference standard?. ### Response: Concerns in usingmulti-detector computed tomography for diagnosing pulmonaryembolism in daily practice.


Instruction: What was used as a reference standard in the cross-sectional analysis?

Output: expertopinion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was used as a reference standard in the cross-sectional analysis?. ### Response: expertopinion.


Instruction: What did Stein PD, Fowler SE, Goodman LR, et al. use for acute pulmonary embolism?

Output: Multidetector computedtomography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Stein PD, Fowler SE, Goodman LR, et al. use for acute pulmonary embolism?. ### Response: Multidetector computedtomography.


Instruction: How many(22):2317-2327.115?

Output: 354

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many(22):2317-2327.115?. ### Response: 354.


Instruction: What is the name of the prospective multicenter assessment of interobserveragreement for radiologist interpretation of multidetectorcomputerized tomographic angiography for pulmonary embolism?

Output: Hogg M,Kline JA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective multicenter assessment of interobserveragreement for radiologist interpretation of multidetectorcomputerized tomographic angiography for pulmonary embolism?. ### Response: Hogg M,Kline JA.


Instruction: When did the JThromb Haemost issue 8(3):533-539?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the JThromb Haemost issue 8(3):533-539?. ### Response: 2010.


Instruction: What is the diagnosis of subsegmental thrombosis in patients withsuspected pulmonary embolism?

Output: computed tomography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the diagnosis of subsegmental thrombosis in patients withsuspected pulmonary embolism?. ### Response: computed tomography.


Instruction: When did J Thromb Haemost issue 10(3):496-498?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J Thromb Haemost issue 10(3):496-498?. ### Response: 2012.


Instruction: What is a positive compressionultrasonography of the lower limb veins highly predictive of?

Output: pulmonary embolism.J Thromb Haemost . 2010;8(3):533-539 .116. Pena E, Kimpton M, Dennie C, Peterson R, G LEG, Carrier M.Difference in interpretation of computed tomography pulmonaryangiography diagnosis of subsegmental thrombosis in patients withsuspected pulmonary embolism. J Thromb Haemost . 2012;10(3):496-498 .117. Le Gal G, Righini M, Parent F, van Strijen M, Couturaud F.Diagnosis and management of subsegmental pulmonary embolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a positive compressionultrasonography of the lower limb veins highly predictive of?. ### Response: pulmonary embolism.J Thromb Haemost . 2010;8(3):533-539 .116. Pena E, Kimpton M, Dennie C, Peterson R, G LEG, Carrier M.Difference in interpretation of computed tomography pulmonaryangiography diagnosis of subsegmental thrombosis in patients withsuspected pulmonary embolism. J Thromb Haemost . 2012;10(3):496-498 .117. Le Gal G, Righini M, Parent F, van Strijen M, Couturaud F.Diagnosis and management of subsegmental pulmonary embolism.


Instruction: What is a prospective multicentre study of ditis?

Output: Eur Heart J. 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a prospective multicentre study of ditis?. ### Response: Eur Heart J. 2007.


Instruction: When did Eur Heart J.28:1155-61?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Eur Heart J.28:1155-61?. ### Response: 2007.


Instruction: What did Duval X, Iung B, Klein I, et al. do?

Output: Effect of early cerebral magnetic resonance imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Duval X, Iung B, Klein I, et al. do?. ### Response: Effect of early cerebral magnetic resonance imaging.


Instruction: How did early cerebral magnetic resonance imaging affect clinical decisions in infective endocarditis: a study?

Output: Effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did early cerebral magnetic resonance imaging affect clinical decisions in infective endocarditis: a study?. ### Response: Effect.


Instruction: In what year was Ann Intern Med published?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was Ann Intern Med published?. ### Response: 2010.


Instruction: What is the difference between oral and intravenous antibi-otic treatment of endocarditis?

Output: Partial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between oral and intravenous antibi-otic treatment of endocarditis?. ### Response: Partial.


Instruction: What year was Medicine (Baltimore) published?

Output: 1978

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was Medicine (Baltimore) published?. ### Response: 1978.


Instruction: What is Bleeding Risk?

Output: PCI in Hospitals Without On-Site SurgicalBackup

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Bleeding Risk?. ### Response: PCI in Hospitals Without On-Site SurgicalBackup.


Instruction: What is PCI in Hospitals Without On-Site SurgicalBackup: Recommendations?

Output: Procedural Considerations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PCI in Hospitals Without On-Site SurgicalBackup: Recommendations?. ### Response: Procedural Considerations.


Instruction: What are the recommendations for Primary PCI of the InfarctArtery?

Output: .e5985.2.2.3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the recommendations for Primary PCI of the InfarctArtery?. ### Response: .e5985.2.2.3.


Instruction: Cardiogenic Shock:Recommendations................................e6005.2.3.1. Cardiovascularization Before NoncardiacSurgery:Procedural Considerations forCardiogenic Shock?

Output: ............... .e6005.2.3.1. Procedural Considerations forCardiogenic Shock ........

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cardiogenic Shock:Recommendations................................e6005.2.3.1. Cardiovascularization Before NoncardiacSurgery:Procedural Considerations forCardiogenic Shock?. ### Response: ............... .e6005.2.3.1. Procedural Considerations forCardiogenic Shock .........


Instruction: What are the recommendations for Coronary Stents?

Output: Recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the recommendations for Coronary Stents?. ### Response: Recommendations.


Instruction: What is the recommendation for IVUS?

Output: Optical Coherence Tomography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommendation for IVUS?. ### Response: Optical Coherence Tomography.


Instruction: How is IVUS performed?

Output: Recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is IVUS performed?. ### Response: Recommendations.


Instruction: What type of Angioplasty is recommended?

Output: Cutting Balloon

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of Angioplasty is recommended?. ### Response: Cutting Balloon.


Instruction: What is the name of the device recommended by the ACCF/AHA/SCAI PCI guideline?

Output: Oral Antiplatelet Therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the device recommended by the ACCF/AHA/SCAI PCI guideline?. ### Response: Oral Antiplatelet Therapy.


Instruction: When was the PCI Guideline e575 released?

Output: May 1, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the PCI Guideline e575 released?. ### Response: May 1, 2023.


Instruction: What is the name of the organization that provides a summary of recommendations and practice points for physical activity interventions?

Output: kidney-international.org

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that provides a summary of recommendations and practice points for physical activity interventions?. ### Response: kidney-international.org.


Instruction: https://www.healthquality.va.gov/guidelines/CD/diabetes/ 8 See the VA/DoD Clinical Practice Guideline for Screening and Management of what?

Output: Obesity and Overweight

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: https://www.healthquality.va.gov/guidelines/CD/diabetes/ 8 See the VA/DoD Clinical Practice Guideline for Screening and Management of what?. ### Response: Obesity and Overweight.


Instruction: What are the preferred sources of protein?

Output: Fish, legumes, and poultry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the preferred sources of protein?. ### Response: Fish, legumes, and poultry.


Instruction: What is important to reduce the consumption of?

Output: trans fats, added sugars (including sugar-sweetened beverages), red meats, sodium, and saturated fats

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is important to reduce the consumption of?. ### Response: trans fats, added sugars (including sugar-sweetened beverages), red meats, sodium, and saturated fats.


Instruction: Who should work in partnership with patients to assess their readiness for sustained lifestyle improvements?

Output: Clinicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should work in partnership with patients to assess their readiness for sustained lifestyle improvements?. ### Response: Clinicians.


Instruction: What should patients do to assess their readiness for sustained lifestyle improvements?

Output: make healthier lifestyle changes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients do to assess their readiness for sustained lifestyle improvements?. ### Response: make healthier lifestyle changes.


Instruction: What must social determinants of ASCVD risk and their impact on the patient’s ability to treat risk factors be taken into account?

Output: pre-vent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must social determinants of ASCVD risk and their impact on the patient’s ability to treat risk factors be taken into account?. ### Response: pre-vent.


Instruction: What must a patient have to be able to do to prevent or treat risk factors?

Output: make healthier lifestyle changes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must a patient have to be able to do to prevent or treat risk factors?. ### Response: make healthier lifestyle changes.


Instruction: What should a clinician do to assess their patients' motivation to im-prove their lifestyle habits?

Output: consider patients’ health literacy and education levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should a clinician do to assess their patients' motivation to im-prove their lifestyle habits?. ### Response: consider patients’ health literacy and education levels.


Instruction: The goal of a clinician is to match the intensity of preventive efforts with an individual's absolute risk of what?

Output: a future ASCVD event

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The goal of a clinician is to match the intensity of preventive efforts with an individual's absolute risk of what?. ### Response: a future ASCVD event.


Instruction: What is imperfect and based on group aver -ages that are then applied to individual patients?

Output: Risk estimation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is imperfect and based on group aver -ages that are then applied to individual patients?. ### Response: Risk estimation.


Instruction: What must the clinician balance an understanding of a patient’s risk of future ASCVD event with?

Output: potential benefits and ad-verse risk from pharmacological therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must the clinician balance an understanding of a patient’s risk of future ASCVD event with?. ### Response: potential benefits and ad-verse risk from pharmacological therapy.


Instruction: What must the clinician balance an understanding of a patient's estimated ASCVD risk with potential benefits and ad-verse risk from pharmacological therapy?

Output: risk discussion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must the clinician balance an understanding of a patient's estimated ASCVD risk with potential benefits and ad-verse risk from pharmacological therapy?. ### Response: risk discussion.


Instruction: What can inform decision-making for cholesterol-lowering or antihypertensive medication use in intermediate-risk individuals?

Output: risk-enhancing factors or selective use of a coronary artery calcium measure-ment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can inform decision-making for cholesterol-lowering or antihypertensive medication use in intermediate-risk individuals?. ### Response: risk-enhancing factors or selective use of a coronary artery calcium measure-ment.


Instruction: What does this primary-prevention guideline strive to provide to clinicians?

Output: the information they need to help their patients reduce their risk of ASCVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does this primary-prevention guideline strive to provide to clinicians?. ### Response: the information they need to help their patients reduce their risk of ASCVD.


Instruction: Who is the ACC/AHA TASK FORCE MEMBERS?

Output: SPatrick T. O’Gara, MD, MACC, FAHA, Chair

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the ACC/AHA TASK FORCE MEMBERS?. ### Response: SPatrick T. O’Gara, MD, MACC, FAHA, Chair.


Instruction: What is the name of the person who is the Chair-Elect of the AHA Task Force?

Output: Joshua A. Beckman

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the person who is the Chair-Elect of the AHA Task Force?. ### Response: Joshua A. Beckman.


Instruction: Who is the FAHA's Immediate Past Chair*?

Output: Glenn N. Levine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the FAHA's Immediate Past Chair*?. ### Response: Glenn N. Levine.


Instruction: What is Sana M. Al-Khatib's specialty?

Output: MD, MHS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Sana M. Al-Khatib's specialty?. ### Response: MD, MHS.


Instruction: Who is a member of the AACC?

Output: Kim K. Birtcher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a member of the AACC?. ### Response: Kim K. Birtcher.


Instruction: D. Goldberger, MD, MS, FACC, FAHA*; Mark A. Hlatky, MD FACC; FAHA; John Ikonomidis, MD PhD; José A. Joglar, MD; MSc, FAH; Mariann R. Piano, PhD; Barbara Riegel, PhD, RN; Duminda N. Wijeysundera, MD?

Output: patients’ health literacy and education levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: D. Goldberger, MD, MS, FACC, FAHA*; Mark A. Hlatky, MD FACC; FAHA; John Ikonomidis, MD PhD; José A. Joglar, MD; MSc, FAH; Mariann R. Piano, PhD; Barbara Riegel, PhD, RN; Duminda N. Wijeysundera, MD?. ### Response: patients’ health literacy and education levels.


Instruction: Former Task Force member; current member of what group?

Output: during the writing effort

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Former Task Force member; current member of what group?. ### Response: during the writing effort.


Instruction: Duminda N. Wijeysundera is a former member of what task force?

Output: Task Force

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Duminda N. Wijeysundera is a former member of what task force?. ### Response: Task Force.


Instruction: What is a risk-enhancing factor for ASCVD?

Output: CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk-enhancing factor for ASCVD?. ### Response: CKD.


Instruction: What favors initiation of statin therapy in intermediate-risk patients?

Output: CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What favors initiation of statin therapy in intermediate-risk patients?. ### Response: CKD.


Instruction: In adults with CKD that requires dialysis treatment, initiation of a statin is not recommended on the basis of how many large-scale RCTs?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In adults with CKD that requires dialysis treatment, initiation of a statin is not recommended on the basis of how many large-scale RCTs?. ### Response: 2.


Instruction: Reduced eGFR (60 mL/min/1.73 m2 not on dialy-sis) and presence of albuminuria are what?

Output: independently associated with elevated risk of ASCVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Reduced eGFR (60 mL/min/1.73 m2 not on dialy-sis) and presence of albuminuria are what?. ### Response: independently associated with elevated risk of ASCVD.


Instruction: What is the ratio of albumin-to-creatinine ratio 30 mcg/mg?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ratio of albumin-to-creatinine ratio 30 mcg/mg?. ### Response: ≥.


Instruction: What does CKD count as in intermediate-risk patients?

Output: a risk-enhancing factor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CKD count as in intermediate-risk patients?. ### Response: a risk-enhancing factor.


Instruction: What increases the risk of CVD in patients with diabetes mellitus and no CKD?

Output: Presence of albuminuria with reduced eGFR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What increases the risk of CVD in patients with diabetes mellitus and no CKD?. ### Response: Presence of albuminuria with reduced eGFR.


Instruction: What is the risk graded and increases with severity of eGFR impairment?

Output: observed threshold of risk beginning around 75 mL/min/1.73 m2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk graded and increases with severity of eGFR impairment?. ### Response: observed threshold of risk beginning around 75 mL/min/1.73 m2.


Instruction: The observed threshold of risk begins around what?

Output: 75 mL/min/1.73 m2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The observed threshold of risk begins around what?. ### Response: 75 mL/min/1.73 m2.


Instruction: What is the risk associated with albuminuria linear?

Output: 75 mL/min/1.73 m2, whereas the risk associated with albuminuria is linear

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk associated with albuminuria linear?. ### Response: 75 mL/min/1.73 m2, whereas the risk associated with albuminuria is linear.


Instruction: What does statin use show?

Output: abso-lute benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does statin use show?. ### Response: abso-lute benefit.


Instruction: The benefit of statin is consistent across what stages of CKD?

Output: eGFR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The benefit of statin is consistent across what stages of CKD?. ### Response: eGFR.


Instruction: What is independently associated with CVD risk?

Output: Albuminuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is independently associated with CVD risk?. ### Response: Albuminuria.


Instruction: What was the one trial done for primary prevention in persons with albu-minuria and preserved eGFR?

Output: S4.5.4-72

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the one trial done for primary prevention in persons with albu-minuria and preserved eGFR?. ### Response: S4.5.4-72.


Instruction: What is the name of the SHARP trial?

Output: Study of Heart and Renal Protection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the SHARP trial?. ### Response: Study of Heart and Renal Protection.


Instruction: What percentage of people transitioned to dialysis?

Output: >30%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of people transitioned to dialysis?. ### Response: >30%.


Instruction: What was performed to reduce LDL-C?

Output: weighting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was performed to reduce LDL-C?. ### Response: weighting.


Instruction: What was similar in patients on dialysis and those who were not?

Output: the pro-portional effects on major atherosclerotic events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was similar in patients on dialysis and those who were not?. ### Response: the pro-portional effects on major atherosclerotic events.


Instruction: Who has the highest absolute risk of events?

Output: persons on dialysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who has the highest absolute risk of events?. ### Response: persons on dialysis.


Instruction: How many deaths are thought to be due to atherosclerotic events?

Output: lower

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many deaths are thought to be due to atherosclerotic events?. ### Response: lower.


Instruction: The lack of benefit in RCTs with statin initiation among persons on dialysis raises the question of what?

Output: competing risks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The lack of benefit in RCTs with statin initiation among persons on dialysis raises the question of what?. ### Response: competing risks.


Instruction: What do direct thrombin inhibitors bind to and block its enzymatic activity?

Output: thrombin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do direct thrombin inhibitors bind to and block its enzymatic activity?. ### Response: thrombin.


Instruction: What are the cur-rently approved direct Thrombin inhibitors?

Output: hiru-din, bivalirudin, and argatroban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the cur-rently approved direct Thrombin inhibitors?. ### Response: hiru-din, bivalirudin, and argatroban.


Instruction: How do indirect anticoagulants work?

Output: require a plasma cofactor to exert their activity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do indirect anticoagulants work?. ### Response: require a plasma cofactor to exert their activity.


Instruction: Hirudin A 65-amino acid polypeptide was originally isolated from the salivary glands of what plant?

Output: leech

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hirudin A 65-amino acid polypeptide was originally isolated from the salivary glands of what plant?. ### Response: leech.


Instruction: Hirudine A 214,215 is now available in what form?

Output: recombinant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hirudine A 214,215 is now available in what form?. ### Response: recombinant.


Instruction: Recombinant hirudins differ from what in that they are expressed in yeast?

Output: native hirudin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Recombinant hirudins differ from what in that they are expressed in yeast?. ### Response: native hirudin.


Instruction: What are recombinant hirudins different from?

Output: native hirudin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are recombinant hirudins different from?. ### Response: native hirudin.


Instruction: What is the Tyr residue at position 63 not sulfated?

Output: recombinant hirudins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Tyr residue at position 63 not sulfated?. ### Response: recombinant hirudins.


Instruction: Which two forms of harudin are currently approved for clinical use in North America and Europe?

Output: lepirudin and desiru-din

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which two forms of harudin are currently approved for clinical use in North America and Europe?. ### Response: lepirudin and desiru-din.


Instruction: What is Lepirudin licensed for?

Output: treatment of thrombosis complicating HIT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Lepirudin licensed for?. ### Response: treatment of thrombosis complicating HIT.


Instruction: What is approved in Europe and the United States for postoperative thromboprophy-laxis in patients undergoing elective hiparthroplasty?

Output: desirudin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is approved in Europe and the United States for postoperative thromboprophy-laxis in patients undergoing elective hiparthroplasty?. ### Response: desirudin.


Instruction: What are the two forms of recombinant hirudin's mechanism of action and pharmaco-kinetic properties identical?

Output: lepirudin and desiru-din

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the two forms of recombinant hirudin's mechanism of action and pharmaco-kinetic properties identical?. ### Response: lepirudin and desiru-din.


Instruction: What do both forms inhibit in a bivalent fashion?

Output: thrombin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do both forms inhibit in a bivalent fashion?. ### Response: thrombin.


Instruction: The anionic carboxy-terminal tails bind to what site on thrombin?

Output: exosite 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The anionic carboxy-terminal tails bind to what site on thrombin?. ### Response: exosite 1.


Instruction: Where does lepirudin and desirudin form high-affi nity 1:1 stoichiometric complexes with thrombin that are essentially irreversible?

Output: 215   Both lepirudin and desirudin form high-af

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where does lepirudin and desirudin form high-affi nity 1:1 stoichiometric complexes with thrombin that are essentially irreversible?. ### Response: 215   Both lepirudin and desirudin form high-af.


Instruction: What is the recommended dose of IV lepirudin for HIT?

Output: 0.15 mg/kg/h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommended dose of IV lepirudin for HIT?. ### Response: 0.15 mg/kg/h.


Instruction: What is the IV dose of lepirudin for HIT?

Output: 0.15 mg/kg/h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the IV dose of lepirudin for HIT?. ### Response: 0.15 mg/kg/h.


Instruction: What is monitored by using the aPTT?

Output: The anticoagulant effect of lepirudin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is monitored by using the aPTT?. ### Response: The anticoagulant effect of lepirudin.


Instruction: What is the ratio of 1.5 to 2.5 times control?

Output: aPTT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ratio of 1.5 to 2.5 times control?. ### Response: aPTT.


Instruction: What is given subcutaneously at a dose of 15 mg twice daily with-out monitoring?

Output: desirudin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is given subcutaneously at a dose of 15 mg twice daily with-out monitoring?. ### Response: desirudin.


Instruction: How long is the plasma half-life of hirudins after IV injection?

Output: 60 min

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the plasma half-life of hirudins after IV injection?. ### Response: 60 min.


Instruction: What is the half-life of hirudins after IV injection?

Output: 60 min

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the half-life of hirudins after IV injection?. ### Response: 60 min.


Instruction: How long is half-live after subcutaneous injec-tion?

Output: 120 min

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is half-live after subcutaneous injec-tion?. ### Response: 120 min.


Instruction: What is cleared via the kidneys?

Output: Hirudin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is cleared via the kidneys?. ### Response: Hirudin.


Instruction: When was Kimberly Henricks published?

Output: February 10, 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Kimberly Henricks published?. ### Response: February 10, 2012.


Instruction: What did the panel identify as additional research priorities?

Output: a standardized definition of what constitutes a patienteducation intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the panel identify as additional research priorities?. ### Response: a standardized definition of what constitutes a patienteducation intervention.


Instruction: What was the goal of the panel?

Output: anticoagulation control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the goal of the panel?. ### Response: anticoagulation control.


Instruction: What is associated with higher rates of hospital admissions, suboptimal health outcomes, in-creased morbidity and mortality, and increased health carecosts?

Output: nonadherence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with higher rates of hospital admissions, suboptimal health outcomes, in-creased morbidity and mortality, and increased health carecosts?. ### Response: nonadherence.


Instruction: How many RCTs did we find that addressed specific interventions to improve anticoagulation therapy adherence?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs did we find that addressed specific interventions to improve anticoagulation therapy adherence?. ### Response: 3.


Instruction: How many EtDframeworks did we prepare for each adherence intervention?

Output: separate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many EtDframeworks did we prepare for each adherence intervention?. ### Response: separate.


Instruction: How many EtDframeworks are recommended for each adherence intervention?

Output: 13a through 13

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many EtDframeworks are recommended for each adherence intervention?. ### Response: 13a through 13.


Instruction: What is a 1-in-5 chance of a monetary reward each day if a pill compartment on a sophisticated electronic medication monitoring system is accessed?

Output: 100

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a 1-in-5 chance of a monetary reward each day if a pill compartment on a sophisticated electronic medication monitoring system is accessed?. ### Response: 100.


Instruction: How is compartment on a sophisticated elec-tronic medication monitoring system accessed?

Output: separate EtDframeworks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is compartment on a sophisticated elec-tronic medication monitoring system accessed?. ### Response: separate EtDframeworks.


Instruction: What is conditional recommendation based on?

Output: very low certainty in the evidence about effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is conditional recommendation based on?. ### Response: very low certainty in the evidence about effects.


Instruction: How many RCTs reported the effect of a daily lottery-based incentive intervention for patients usingVKA?

Output: Two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs reported the effect of a daily lottery-based incentive intervention for patients usingVKA?. ### Response: Two.


Instruction: What was the main outcome of the lottery arm?

Output: anticoagulation control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the main outcome of the lottery arm?. ### Response: anticoagulation control.


Instruction: What was measured by out-of-range INRs?

Output: anticoagulation control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was measured by out-of-range INRs?. ### Response: anticoagulation control.


Instruction: Who had a 1-in-5 chance of a monetary reward each day?

Output: participants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who had a 1-in-5 chance of a monetary reward each day?. ### Response: participants.


Instruction: What was the main outcome of the study?

Output: anticoagulation control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the main outcome of the study?. ### Response: anticoagulation control.


Instruction: What were the secondary outcomes?

Output: mortality, bleeding, and thromboembolic events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the secondary outcomes?. ### Response: mortality, bleeding, and thromboembolic events.


Instruction: Where is the EtDframework shown online?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the EtDframework shown online?. ### Response: https://dbep.gradepro.org.


Instruction: What was the percentage time out of INRrange?

Output: 0.98

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the percentage time out of INRrange?. ### Response: 0.98.


Instruction: What percentage of days with incorrect adherence were there no differences?

Output: 0.84

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of days with incorrect adherence were there no differences?. ### Response: 0.84.


Instruction: What is the full-adjusted OR for likelihood of nonadherence?

Output: 0.84

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the full-adjusted OR for likelihood of nonadherence?. ### Response: 0.84.


Instruction: How many more deaths per 1000?

Output: 8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many more deaths per 1000?. ### Response: 8.


Instruction: PE/DVT is what?

Output: ARR, 26 more per 1000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: PE/DVT is what?. ### Response: ARR, 26 more per 1000.


Instruction: What is the Cochrane Collaboration's tool for assessing risk of bias in randomised trials?

Output: Cochrane Bias Methods Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Cochrane Collaboration's tool for assessing risk of bias in randomised trials?. ### Response: Cochrane Bias Methods Group.


Instruction: When did BMJ issue 343:d5928?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did BMJ issue 343:d5928?. ### Response: 2011.


Instruction: What year did the BMJ publish a study on stroke in patients with symptomatic carotid stenosis awaiting revascularization?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did the BMJ publish a study on stroke in patients with symptomatic carotid stenosis awaiting revascularization?. ### Response: 2011.


Instruction: What is the name of the study that examined the recurrent stroke of patients with what type of stenotic disease?

Output: carotid stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined the recurrent stroke of patients with what type of stenotic disease?. ### Response: carotid stenosis.


Instruction: What is safe after thrombolysis for minor to mod-erate acute ischemic stroke?

Output: Urgent carotid intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is safe after thrombolysis for minor to mod-erate acute ischemic stroke?. ### Response: Urgent carotid intervention.


Instruction: What year did J Vasc Surg.62:1529-1538?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did J Vasc Surg.62:1529-1538?. ### Response: 2015.


Instruction: What type of improvement is associated with early versus delayed carotid endarterectomy in symptomatic patients?

Output: Thirty-day neurologic improvement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of improvement is associated with early versus delayed carotid endarterectomy in symptomatic patients?. ### Response: Thirty-day neurologic improvement.


Instruction: What year did Ann Vasc Surg.29:435-442?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Ann Vasc Surg.29:435-442?. ### Response: 2015.


Instruction: How long did neurologic improvement last?

Output: Thirty-day

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did neurologic improvement last?. ### Response: Thirty-day.


Instruction: What is used in the selection of acute stroke patients to undergo emergent carotid endarterectomy?

Output: Computed tomography perfusion imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used in the selection of acute stroke patients to undergo emergent carotid endarterectomy?. ### Response: Computed tomography perfusion imaging.


Instruction: What is the name of the imaging technique used in acute stroke?

Output: Computed tomography perfusion imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the imaging technique used in acute stroke?. ### Response: Computed tomography perfusion imaging.


Instruction: How many pages are in the Ann Vasc Surg. 2015?

Output: 125.e1–125.11

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many pages are in the Ann Vasc Surg. 2015?. ### Response: 125.e1–125.11.


Instruction: What is assisted by carotid stenting in acute ischemic stroke management?

Output: Thrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is assisted by carotid stenting in acute ischemic stroke management?. ### Response: Thrombectomy.


Instruction: What are the benefits and harms of thromboectomy?

Output: benefits and harms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the benefits and harms of thromboectomy?. ### Response: benefits and harms.


Instruction: How long after transient ischemic attack and stroke did a retrospective study on early carotid endarterectomy take place?

Output: 48 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after transient ischemic attack and stroke did a retrospective study on early carotid endarterectomy take place?. ### Response: 48 hours.


Instruction: What is the name of the retrospective study?

Output: early carotid endarterectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the retrospective study?. ### Response: early carotid endarterectomy.


Instruction: What type of therapy is used in stroke and ICAS?

Output: Dual antiplatelet therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is used in stroke and ICAS?. ### Response: Dual antiplatelet therapy.


Instruction: What is the name of the subgroup analysis of CHANCE?

Output: CHANCE Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the subgroup analysis of CHANCE?. ### Response: CHANCE Investigators.


Instruction: What is the name of the group of investigators that investigated the risk of recurrence of stroke in patients with symptomatic intracranial arterial stenosis?

Output: TOSS-2 Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group of investigators that investigated the risk of recurrence of stroke in patients with symptomatic intracranial arterial stenosis?. ### Response: TOSS-2 Investigators.


Instruction: When did Stroke.43.2785-2787 occur?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Stroke.43.2785-2787 occur?. ### Response: 2012.


Instruction: What is one of the investigators?

Output: CHANCE Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the investigators?. ### Response: CHANCE Investigators.


Instruction: What is the name of the Canadian Stroke Best Practices Advisory Committee?

Output: Heart, and Stroke Foundation Canada

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Canadian Stroke Best Practices Advisory Committee?. ### Response: Heart, and Stroke Foundation Canada.


Instruction: What year were the Canadian stroke best practice recommendations updated?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year were the Canadian stroke best practice recommendations updated?. ### Response: 2014.


Instruction: Int J Stroke. 2015;10:282–291. doi: 10.1111/ijs.12439 516.

Output: Canadian stroke best practice recommendations: secondary prevention of stroke guide-lines, update 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Int J Stroke. 2015;10:282–291. doi: 10.1111/ijs.12439 516.. ### Response: Canadian stroke best practice recommendations: secondary prevention of stroke guide-lines, update 2014.


Instruction: How much higher is the risk of stroke recurrence and death in patients with aCHA 2DS2-VASc score $2?

Output: threefold and 15-fold higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much higher is the risk of stroke recurrence and death in patients with aCHA 2DS2-VASc score $2?. ### Response: threefold and 15-fold higher.


Instruction: What is the difference between ESUS and AF-associated stroke?

Output: phenotypically different from AF-associated stroke, weshould see differences in stroke severity and outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between ESUS and AF-associated stroke?. ### Response: phenotypically different from AF-associated stroke, weshould see differences in stroke severity and outcomes.


Instruction: What was not evident in ESUS where AF was detected on follow-up?

Output: difference in National Institutes of HealthStroke Scale score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not evident in ESUS where AF was detected on follow-up?. ### Response: difference in National Institutes of HealthStroke Scale score.


Instruction: What did the National Institutes of HealthStroke Scale score show?

Output: 95%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the National Institutes of HealthStroke Scale score show?. ### Response: 95%,.


Instruction: What has a strong effect onrecurrence risk and mortality?

Output: age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has a strong effect onrecurrence risk and mortality?. ### Response: age.


Instruction: Current guidelines recommend use of what in ESUS patients?

Output: antiplatelet agents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Current guidelines recommend use of what in ESUS patients?. ### Response: antiplatelet agents.


Instruction: What would be managed with oral anticoagulation?

Output: ESUS patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would be managed with oral anticoagulation?. ### Response: ESUS patients.


Instruction: What is the rate of stroke recurrence per year?

Output: >4%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the rate of stroke recurrence per year?. ### Response: >4%.


Instruction: What is an important clinical need for more effective antithrombotic therapy for ESUS?

Output: undetected AF,oral anticoagulation is a theoretically attractive option.Ongoing randomized trials comparing NOACs withaspirin in ESUS patients are in progress. Prior to datafrom these trials, physicians might, in the meantime,consider the use of anticoagulation in parallel withcontinued cardiac evaluation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an important clinical need for more effective antithrombotic therapy for ESUS?. ### Response: undetected AF,oral anticoagulation is a theoretically attractive option.Ongoing randomized trials comparing NOACs withaspirin in ESUS patients are in progress. Prior to datafrom these trials, physicians might, in the meantime,consider the use of anticoagulation in parallel withcontinued cardiac evaluation.


Instruction: What is a theoretically attractive option for undetected AF?

Output: oral anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a theoretically attractive option for undetected AF?. ### Response: oral anticoagulation.


Instruction: Ongoing randomized trials comparing NOACs withaspirin in ESUS patients are in progress.

Output: 366

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Ongoing randomized trials comparing NOACs withaspirin in ESUS patients are in progress.. ### Response: 366.


Instruction: What is an example of cardiac evaluation?

Output: prolonged rhythmmonitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of cardiac evaluation?. ### Response: prolonged rhythmmonitoring.


Instruction: What are AHREs Detected by Cardiac ImplantedElectronic Devices?

Output: Cardiac implanted

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are AHREs Detected by Cardiac ImplantedElectronic Devices?. ### Response: Cardiac implanted.


Instruction: What are atrial tachyarrhythmias, including AF, asAHREs?

Output: implantable cardiac monitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are atrial tachyarrhythmias, including AF, asAHREs?. ### Response: implantable cardiac monitors.


Instruction: What is currently defined as episodes of at least 5 min ofatrial taryarrhythmis/AF with an atrial rate >180beats/min?

Output: AHREs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is currently defined as episodes of at least 5 min ofatrial taryarrhythmis/AF with an atrial rate >180beats/min?. ### Response: AHREs.


Instruction: Asymptomatic, discovered during routine device follow-up, are usually discovered during what?

Output: AHREs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Asymptomatic, discovered during routine device follow-up, are usually discovered during what?. ### Response: AHREs.


Instruction: When are atrialtachyarrhythmias discovered?

Output: duringroutine device follow-up

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When are atrialtachyarrhythmias discovered?. ### Response: duringroutine device follow-up.


Instruction: What is classi fied in terms of?

Output: duration of the single episode or time spent in atrialtachyarrhythmias during a day

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is classi fied in terms of?. ### Response: duration of the single episode or time spent in atrialtachyarrhythmias during a day.


Instruction: How long have temporal cutoffs been used for detection and storage of data?

Output: as short as 30 to 60 s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long have temporal cutoffs been used for detection and storage of data?. ### Response: as short as 30 to 60 s.


Instruction: How accurate is thediagnostic accuracy when episodes $5 min induration are considered?

Output: reliable

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How accurate is thediagnostic accuracy when episodes $5 min induration are considered?. ### Response: reliable.


Instruction: Theappropriateness in AF detection is what percentage?

Output: 95%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Theappropriateness in AF detection is what percentage?. ### Response: 95%,.


Instruction: What is the risk of over-sensing due to detection of artifacts?

Output: minimizing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of over-sensing due to detection of artifacts?. ### Response: minimizing.


Instruction: What is a cause of electrical interference?

Output: myopotentials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a cause of electrical interference?. ### Response: myopotentials.


Instruction: What is clinically indicated to exclude artifacts or other causes?

Output: Individual patient analysis ofelectrograms corresponding to AHREs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is clinically indicated to exclude artifacts or other causes?. ### Response: Individual patient analysis ofelectrograms corresponding to AHREs.


Instruction: Why was the trial stopped early?

Output: superiority of VKA therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the trial stopped early?. ### Response: superiority of VKA therapy.


Instruction: What was the primary out-come of the trial?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary out-come of the trial?. ### Response: stroke.


Instruction: What percentage of patients were receiving VKA therapy before randomization?

Output: 77%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients were receiving VKA therapy before randomization?. ### Response: 77%).


Instruction: What is the risk of major bleeding in patients with AF?

Output: nonfatal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of major bleeding in patients with AF?. ### Response: nonfatal.


Instruction: How does VKA therapy reduce the risk of systemic embo-lism?

Output: moderate-quality evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does VKA therapy reduce the risk of systemic embo-lism?. ### Response: moderate-quality evidence.


Instruction: What is another name for Aspirin?

Output: Antiplatelet Monotherapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for Aspirin?. ### Response: Antiplatelet Monotherapy.


Instruction: How many RCTs have shown that antiplatelet monotherapy vs no therapy is effective?

Output: Several

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs have shown that antiplatelet monotherapy vs no therapy is effective?. ### Response: Several.


Instruction: What has shown that antiplatelet therapy leads to at best a modest reduction in the risk of nonfatal stroke?

Output: Several RCTs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has shown that antiplatelet therapy leads to at best a modest reduction in the risk of nonfatal stroke?. ### Response: Several RCTs.


Instruction: What was the mono-therapy in these trials with aspirin?

Output: antiplatelet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mono-therapy in these trials with aspirin?. ### Response: antiplatelet.


Instruction: What is the UK-TIA trial?

Output: United Kingdom Tran-sient Ischaemic Attack Aspirin trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the UK-TIA trial?. ### Response: United Kingdom Tran-sient Ischaemic Attack Aspirin trial.


Instruction: What are the names of the European Stroke Prevention Study and JAST?

Output: LASAF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the European Stroke Prevention Study and JAST?. ### Response: LASAF.


Instruction: How is aspirin in combination with fixed minidose warfarin?

Output: Antiplatelet mono-therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is aspirin in combination with fixed minidose warfarin?. ### Response: Antiplatelet mono-therapy.


Instruction: What is SAFT?

Output: Swedish Atrial Fibrillation Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SAFT?. ### Response: Swedish Atrial Fibrillation Trial.


Instruction: What is dipyridamole?

Output: ESPS-2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is dipyridamole?. ### Response: ESPS-2.


Instruction: How many mg/d did aspirin do in the LASAF, JAST, and SAFT trials?

Output: 50 to 325

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mg/d did aspirin do in the LASAF, JAST, and SAFT trials?. ### Response: 50 to 325.


Instruction: In the remaining trials, what was the comparison to placebo?

Output: aspirin alone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the remaining trials, what was the comparison to placebo?. ### Response: aspirin alone.


Instruction: ESPS-2 and UK-TIA were stroke prevention trials conducted primarily in what populations?

Output: non-AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ESPS-2 and UK-TIA were stroke prevention trials conducted primarily in what populations?. ### Response: non-AF.


Instruction: Pooled data from these trials provide what quality of evidence?

Output: moderate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Pooled data from these trials provide what quality of evidence?. ### Response: moderate.


Instruction: How much reduction in risk of nonfatal stroke is antiplatelet monotherapy associated with?

Output: 21%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much reduction in risk of nonfatal stroke is antiplatelet monotherapy associated with?. ### Response: 21%.


Instruction: What is rated down for imprecision in the pooled data from these trials?

Output: antiplatelet monotherapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is rated down for imprecision in the pooled data from these trials?. ### Response: antiplatelet monotherapy.


Instruction: What is our confidence in aspirin's bleeding risk?

Output: high

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is our confidence in aspirin's bleeding risk?. ### Response: high.


Instruction: What was underpowered to precisely estimate the risk of nonfatal major extracranial bleeding in patients with AF?

Output: antiplatelet monotherapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was underpowered to precisely estimate the risk of nonfatal major extracranial bleeding in patients with AF?. ### Response: antiplatelet monotherapy.


Instruction: What has been shown to be associated with an increased risk of major hemorrhage?

Output: aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been shown to be associated with an increased risk of major hemorrhage?. ### Response: aspirin.


Instruction: How many cardiovascular primary prevention trials were included in the meta-analysis?

Output: six

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many cardiovascular primary prevention trials were included in the meta-analysis?. ### Response: six.


Instruction: How many subjects participated in prevention trials?

Output: 95,000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many subjects participated in prevention trials?. ### Response: 95,000.


Instruction: How many cardiovascular secondary pre-vention trials participated in a meta-analysis?

Output: 60

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many cardiovascular secondary pre-vention trials participated in a meta-analysis?. ### Response: 60.


Instruction: What drug is associated with a signifiable 50% to 60% relative increase in the risk of major extracranial bleeding?

Output: aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug is associated with a signifiable 50% to 60% relative increase in the risk of major extracranial bleeding?. ### Response: aspirin.


Instruction: What can be assessed by Doppler echocardiography?

Output: An elevated pulmonary pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be assessed by Doppler echocardiography?. ### Response: An elevated pulmonary pressure.


Instruction: What may decrease in pulmonary pressure after relief of rheumatic MS?

Output: some patients will have developed intrinsic pulmonary vascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may decrease in pulmonary pressure after relief of rheumatic MS?. ### Response: some patients will have developed intrinsic pulmonary vascular disease.


Instruction: Some patients will have developed what?

Output: intrinsic pulmonary vascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Some patients will have developed what?. ### Response: intrinsic pulmonary vascular disease.


Instruction: What is the survival rate in patients who have pulmonary hypertension before Figure 7?

Output: poorer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the survival rate in patients who have pulmonary hypertension before Figure 7?. ### Response: poorer.


Instruction: What does AF indicate?

Output: atrial fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does AF indicate?. ### Response: atrial fibrillation.


Instruction: CVC, Comprehensive Valve Center, what does MS mean?

Output: mitral stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: CVC, Comprehensive Valve Center, what does MS mean?. ### Response: mitral stenosis.


Instruction: What is the name of the New York Heart Association?

Output: NYHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the New York Heart Association?. ### Response: NYHA.


Instruction: What does PASP stand for?

Output: pulmonary artery systolic pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does PASP stand for?. ### Response: pulmonary artery systolic pressure.


Instruction: Where can you download this article?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you download this article?. ### Response: http://ahajournals.org.


Instruction: When was this article published?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this article published?. ### Response: April 28, 2023.


Instruction: Who is the Chair of Harvard Medical School?

Output: Patrick T. O ’Gara

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Chair of Harvard Medical School?. ### Response: Patrick T. O ’Gara.


Instruction: What is the title of the Vice Chair of Tulane University School of Medicine?

Output: Frederick G.Kushner

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of the Vice Chair of Tulane University School of Medicine?. ### Response: Frederick G.Kushner.


Instruction: Where is Dr. Deborah D.Ascheim from?

Output: Mount Sinai School ofMedicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Dr. Deborah D.Ascheim from?. ### Response: Mount Sinai School ofMedicine.


Instruction: What is the name of the UCSF Philip R. Lee Institute forHealth Policy Studies?

Output: Ralph G. Brindis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the UCSF Philip R. Lee Institute forHealth Policy Studies?. ### Response: Ralph G. Brindis.


Instruction: Who is the Dean of the Thomas Jefferson College ofPopulation Health?

Output: Donald E. Casey

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Dean of the Thomas Jefferson College ofPopulation Health?. ### Response: Donald E. Casey.


Instruction: Who is the founder of the Cleveland Clinic Foundation?

Output: Mina K. Chung

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the founder of the Cleveland Clinic Foundation?. ### Response: Mina K. Chung.


Instruction: What is the name of the professor of medicine?

Output: Christopher B.Granger

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor of medicine?. ### Response: Christopher B.Granger.


Instruction: Who is the Distinguished Chair in ClinicalCare and Research at Southwestern Medical Center?

Output: Audre and Bernard Rapoport

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Distinguished Chair in ClinicalCare and Research at Southwestern Medical Center?. ### Response: Audre and Bernard Rapoport.


Instruction: What is the name of the department of Emergency Medicine?

Output: —Professor and Chair

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the department of Emergency Medicine?. ### Response: —Professor and Chair.


Instruction: Where is James C. Fang located?

Output: University of Utah

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is James C. Fang located?. ### Response: University of Utah.


Instruction: Who is the Director of Cardiac Rehabilitationand Exercise Laboratories at the University of Utah?

Output: Barry A. Franklin William Beaumont Hospital

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Director of Cardiac Rehabilitationand Exercise Laboratories at the University of Utah?. ### Response: Barry A. Franklin William Beaumont Hospital.


Instruction: What is the name of the professor of medicine at Duke Clinical Research Institute?

Output: Christopher B.Granger

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor of medicine at Duke Clinical Research Institute?. ### Response: Christopher B.Granger.


Instruction: What is the name of the professor of epidemiology and public health at Yale University School of Medicine?

Output: Harlan M.Krumholz

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor of epidemiology and public health at Yale University School of Medicine?. ### Response: Harlan M.Krumholz.


Instruction: Who is the assistant professor of medicine at Mayo Clinic?

Output: Jane A.Linderbaum

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the assistant professor of medicine at Mayo Clinic?. ### Response: Jane A.Linderbaum.


Instruction: Who is the Professor of Medicine at Harvard Medical School?

Output: David A. Morrow

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Professor of Medicine at Harvard Medical School?. ### Response: David A. Morrow.


Instruction: What division of Cardiology is Kristin Newby at Duke University Medical Center?

Output: —Professorof Medicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What division of Cardiology is Kristin Newby at Duke University Medical Center?. ### Response: —Professorof Medicine.


Instruction: What is the name of the ACC/AHA/SCAIFOCUSED UPDATE on PRIMARY PERCUTANEOUS CORONARY INTERVENTION FOR PATIENTS WITH ST-ELEVATIONMYOCARDIAL INFARCTION?

Output: AUTHOR RELATIONSHIPS WITH INDUSTRY AND OTHER ENTITIES

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the ACC/AHA/SCAIFOCUSED UPDATE on PRIMARY PERCUTANEOUS CORONARY INTERVENTION FOR PATIENTS WITH ST-ELEVATIONMYOCARDIAL INFARCTION?. ### Response: AUTHOR RELATIONSHIPS WITH INDUSTRY AND OTHER ENTITIES.


Instruction: What is the anatomic substrate of A VNRT?

Output: dual A V nodal physiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the anatomic substrate of A VNRT?. ### Response: dual A V nodal physiology.


Instruction: What is often well tolerated and is rarely life threaten-ing?

Output: A VNRT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is often well tolerated and is rarely life threaten-ing?. ### Response: A VNRT.


Instruction: Patients will typically present with the sudden onset of palpitations and what?

Output: shortness of breath, dizziness, and neck pulsations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients will typically present with the sudden onset of palpitations and what?. ### Response: shortness of breath, dizziness, and neck pulsations.


Instruction: What is a rare manifestation of A VNRT?

Output: Syncope

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a rare manifestation of A VNRT?. ### Response: Syncope.


Instruction: What may occur spontaneously or on provocation with exertion, coffee, tea, or alcohol?

Output: A VNRT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may occur spontaneously or on provocation with exertion, coffee, tea, or alcohol?. ### Response: A VNRT.


Instruction: What is reasonable for ongoing management in patients with recurrent symptomatic MAT?

Output: Metoprolol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable for ongoing management in patients with recurrent symptomatic MAT?. ### Response: Metoprolol.


Instruction: What is typically avoided in the presence of acute decompensated heart failure?

Output: Beta blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is typically avoided in the presence of acute decompensated heart failure?. ### Response: Beta blockers.


Instruction: In patients with severe (particularly bronchospastic) pulmonary disease, what is metoprolol used in?

Output: small studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with severe (particularly bronchospastic) pulmonary disease, what is metoprolol used in?. ### Response: small studies.


Instruction: What has been used in small studies in patients with serious pulmonary disease after correction of hypoxia or other signs of acute decompensation?

Output: metoprolol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been used in small studies in patients with serious pulmonary disease after correction of hypoxia or other signs of acute decompensation?. ### Response: metoprolol.


Instruction: What did intravenous or oral metoprolol result in conversion to?

Output: sinus rhythm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did intravenous or oral metoprolol result in conversion to?. ### Response: sinus rhythm.


Instruction: What was used for maintenance therapy?

Output: oral metoprolol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was used for maintenance therapy?. ### Response: oral metoprolol.


Instruction: What is generally avoided in patients with severe conduction abnormalities or sinus node dysfunction?

Output: Beta blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is generally avoided in patients with severe conduction abnormalities or sinus node dysfunction?. ### Response: Beta blockers.


Instruction: How are vagal maneuvers recommended for acute treatment?

Output: These maneuvers should be performed with the patient in the supine position

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are vagal maneuvers recommended for acute treatment?. ### Response: These maneuvers should be performed with the patient in the supine position.


Instruction: What maneuvers are recommended for acute treatment in patients with AVNRT?

Output: Vagal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What maneuvers are recommended for acute treatment in patients with AVNRT?. ### Response: Vagal.


Instruction: What is the first-line intervention to terminate SVT?

Output: vagal maneuvers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the first-line intervention to terminate SVT?. ### Response: vagal maneuvers.


Instruction: What should be performed with the patient in the supine position?

Output: vagal maneuvers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be performed with the patient in the supine position?. ### Response: vagal maneuvers.


Instruction: There is no “gold standard” for proper Valsalva maneuver technique.

Output: 82

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is no “gold standard” for proper Valsalva maneuver technique.. ### Response: 82.


Instruction: How long does the patient raise intrathoracic pressure by bearing down against a closed glottis?

Output: 10 to 30 seconds

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does the patient raise intrathoracic pressure by bearing down against a closed glottis?. ### Response: 10 to 30 seconds.


Instruction: What is performed after absence of bruit has been confirmed by auscultation?

Output: Carotid massage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is performed after absence of bruit has been confirmed by auscultation?. ### Response: Carotid massage.


Instruction: How long is steady pressure applied over the right or left carotid sinus?

Output: 5 to10 seconds

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is steady pressure applied over the right or left carotid sinus?. ### Response: 5 to10 seconds.


Instruction: What is another vagal maneuver based on the absence of noise?

Output: Syncope

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another vagal maneuver based on the absence of noise?. ### Response: Syncope.


Instruction: What is another vagal maneuver based on the classic diving reflex?

Output: applying an ice-cold, wet towel to the face

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another vagal maneuver based on the classic diving reflex?. ### Response: applying an ice-cold, wet towel to the face.


Instruction: How long does it take to apply an ice-cold, wet towel to the face?

Output: to10 seconds

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take to apply an ice-cold, wet towel to the face?. ### Response: to10 seconds.


Instruction: What temperature does facial immersion in water at 10°C (50°F) have proven effective in terminating tachycardia?

Output: ice-cold

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What temperature does facial immersion in water at 10°C (50°F) have proven effective in terminating tachycardia?. ### Response: ice-cold.


Instruction: How many patients with SVT were involved in a study that showed that Valsalva was more successful than carotid sinus massage?

Output: 148

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with SVT were involved in a study that showed that Valsalva was more successful than carotid sinus massage?. ### Response: 148.


Instruction: What was the overall success rate of switching from one technique to the other?

Output: 27.7%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the overall success rate of switching from one technique to the other?. ### Response: 27.7%..


Instruction: The practice of applying pressure to the eyeball is potentially dangerous and has been abandoned what?

Output: 82

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The practice of applying pressure to the eyeball is potentially dangerous and has been abandoned what?. ### Response: 82.


Instruction: What is potentially dangerous to the eyeball?

Output: applying pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is potentially dangerous to the eyeball?. ### Response: applying pressure.


Instruction: What is recommended for acute treatment in patients with AVNRT?

Output: Vagal maneuvers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for acute treatment in patients with AVNRT?. ### Response: Vagal maneuvers.


Instruction: What is particularly common in patients with HF?

Output: antihypertension treatment strategies such as renin inhibition with aliskiren failed to improve clinical outcomes in patients with HF,80 and catheter-based renal artery denervation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is particularly common in patients with HF?. ### Response: antihypertension treatment strategies such as renin inhibition with aliskiren failed to improve clinical outcomes in patients with HF,80 and catheter-based renal artery denervation.


Instruction: New antihypertension treatment strategies failed to improve what?

Output: clinical outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: New antihypertension treatment strategies failed to improve what?. ### Response: clinical outcomes.


Instruction: What did the SYMPLICITY HTN-3 trial do?

Output: failed to improve clinical outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the SYMPLICITY HTN-3 trial do?. ### Response: failed to improve clinical outcomes.


Instruction: What is Resistant Hypertension?

Output: renal artery denervation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Resistant Hypertension?. ### Response: renal artery denervation.


Instruction: When was this document downloaded?

Output: May 3, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this document downloaded?. ### Response: May 3, 2023.


Instruction: Where did it go?

Output: http://ahajournals.org by on May 3, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where did it go?. ### Response: http://ahajournals.org by on May 3, 2023.


Instruction: What is the gold standard imaging modality?

Output: Cardiac magnetic resonance imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the gold standard imaging modality?. ### Response: Cardiac magnetic resonance imaging.


Instruction: What is a diagnostic and treatment algorithm for repaired TOF?

Output: 751CLINICAL STATEMENTS  AND GUIDELINES

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a diagnostic and treatment algorithm for repaired TOF?. ### Response: 751CLINICAL STATEMENTS  AND GUIDELINES.


Instruction: What is the gold standard imaging modality for quantification of right ventricular size and function in patients with repaired TOF?

Output: Cardiac magnetic resonance imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the gold standard imaging modality for quantification of right ventricular size and function in patients with repaired TOF?. ### Response: Cardiac magnetic resonance imaging.


Instruction: What is used to determine scar tissue in the ventricular myocardium?

Output: Cardiac magnetic resonance imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used to determine scar tissue in the ventricular myocardium?. ### Response: Cardiac magnetic resonance imaging.


Instruction: What allows for longi-tudinal follow-up of patients with repaired TOF?

Output: Serial cardiac magnetic resonance imaging examinations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What allows for longi-tudinal follow-up of patients with repaired TOF?. ### Response: Serial cardiac magnetic resonance imaging examinations.


Instruction: What should be delin-eated before any surgical or percutaneous intervention in patients with TOF?

Output: the origins and proximal courses of the coronary arteries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be delin-eated before any surgical or percutaneous intervention in patients with TOF?. ### Response: the origins and proximal courses of the coronary arteries.


Instruction: Patients with repaired TOF and abnormal coronary artery anatomy have a substantial risk of what during percuta-neous pulmonary valve replacement?

Output: coronary artery compression

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with repaired TOF and abnormal coronary artery anatomy have a substantial risk of what during percuta-neous pulmonary valve replacement?. ### Response: coronary artery compression.


Instruction: What is a percuta-neous pulmonary valve replacement?

Output: surgical pulmonary valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a percuta-neous pulmonary valve replacement?. ### Response: surgical pulmonary valve replacement.


Instruction: What may be demonstrated by performing simultaneous RVOT angiography and coronary angiogram during cardiac catheteriza-tion?

Output: the coronary pattern

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be demonstrated by performing simultaneous RVOT angiography and coronary angiogram during cardiac catheteriza-tion?. ### Response: the coronary pattern.


Instruction: What type of stent will compress the cor -onary artery?

Output: balloon expanded

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of stent will compress the cor -onary artery?. ### Response: balloon expanded.


Instruction: What are some additional risk factors for SCD?

Output: S4.3.5-24,S4.3.5-38,  S4.3.5-39a.  LV systolic or diastolic dysfunctionb

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some additional risk factors for SCD?. ### Response: S4.3.5-24,S4.3.5-38,  S4.3.5-39a.  LV systolic or diastolic dysfunctionb.


Instruction: Nonsustained VT, QRS duration 180 msc?

Output: ≥180 msc.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Nonsustained VT, QRS duration 180 msc?. ### Response: ≥180 msc..


Instruction: 180 msc. Extensive RV fibrosis by CMRIn adults with TOF, inducible sustained VT has been associated with an increased risk of what?

Output: clinical VT or SCD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: 180 msc. Extensive RV fibrosis by CMRIn adults with TOF, inducible sustained VT has been associated with an increased risk of what?. ### Response: clinical VT or SCD.


Instruction: What is most useful in risk stratifying patients at moderate risk of SCD rather than SCD?

Output: Programmed ventricular stimulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is most useful in risk stratifying patients at moderate risk of SCD rather than SCD?. ### Response: Programmed ventricular stimulation.


Instruction: What is the only method that can accurately and reliably determine PA pressure and pulmonary vascular resistance?

Output: Cardiac catheterization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the only method that can accurately and reliably determine PA pressure and pulmonary vascular resistance?. ### Response: Cardiac catheterization.


Instruction: What are symptomatic patients with dyspnea, chest pain, and/or exercise intolerance otherwise unexplained?

Output: unex-plained

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are symptomatic patients with dyspnea, chest pain, and/or exercise intolerance otherwise unexplained?. ### Response: unex-plained.


Instruction: What type of valve replacement is more likely in patients with underlying PSI?

Output: pulmonary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of valve replacement is more likely in patients with underlying PSI?. ### Response: pulmonary.


Instruction: What is the most likely outcome of pulmonary valve replacement?

Output: improved functional class

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most likely outcome of pulmonary valve replacement?. ### Response: improved functional class.


Instruction: How does improvement in symptoms correlate with a reduction in RV size?

Output: relief of PR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does improvement in symptoms correlate with a reduction in RV size?. ### Response: relief of PR.


Instruction: In patients with underlying PS and PR, what is more likely to improve?

Output: Symptom

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with underlying PS and PR, what is more likely to improve?. ### Response: Symptom.


Instruction: Patients with PR alone are more likely than patients with what?

Output: underlying PS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with PR alone are more likely than patients with what?. ### Response: underlying PS.


Instruction: What is the name of the organization that recommends the prevention ofbacterial endocarditis?

Output: American Heart Asso-ciation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that recommends the prevention ofbacterial endocarditis?. ### Response: American Heart Asso-ciation.


Instruction: When did the American Heart Asso-ciation issue its recommendations?

Output: 1997

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the American Heart Asso-ciation issue its recommendations?. ### Response: 1997.


Instruction: What is one of the reasons for the recommendations made?

Output: Prevention ofbacterial endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the reasons for the recommendations made?. ### Response: Prevention ofbacterial endocarditis.