Instruction: What was the name of the Task Force to Revise the 2002 Guidelines for theManagement of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction?

Output: Writing Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the Task Force to Revise the 2002 Guidelines for theManagement of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction?. ### Response: Writing Committee.


Instruction: What is the name of the document produced by AstraZeneca?

Output: Brilinta REMS document

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the document produced by AstraZeneca?. ### Response: Brilinta REMS document.


Instruction: Where can you find the Brilinta REMS document?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find the Brilinta REMS document?. ### Response: http://www.fda.gov/downloads/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/UCM264004.pdf.


Instruction: What are the names of the organizations involved in cardiothoracic surgery?

Output: AmericanCollege of Emergency Physicians, the Society for CardiovascularAngiography and Interventions, and the Society of Thoracic Surgeons

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the organizations involved in cardiothoracic surgery?. ### Response: AmericanCollege of Emergency Physicians, the Society for CardiovascularAngiography and Interventions, and the Society of Thoracic Surgeons.


Instruction: What is the reference ID for ibuprofen?

Output: 2976456

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the reference ID for ibuprofen?. ### Response: 2976456.


Instruction: Where can you find information about the safety of drugs?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find information about the safety of drugs?. ### Response: http://www.fda.gov/downloads/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders.


Instruction: When was this information available?

Output: August 16, 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this information available?. ### Response: August 16, 2011.


Instruction: What was the name of the document that was available at this time?

Output: Brilinta REMS document

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the document that was available at this time?. ### Response: Brilinta REMS document.


Instruction: What is a risk factor for first-time coronary artery bypass grafting?

Output: the anaesthetist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for first-time coronary artery bypass grafting?. ### Response: the anaesthetist.


Instruction: What is anaesthetist's role in risk?

Output: First-time coronary arterybypass grafting: the anaesthetist as a risk factor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is anaesthetist's role in risk?. ### Response: First-time coronary arterybypass grafting: the anaesthetist as a risk factor.


Instruction: When did Slogoff S, Keats AS say that perioperative myocardial ischemia leads to?

Output: topostoperative myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Slogoff S, Keats AS say that perioperative myocardial ischemia leads to?. ### Response: topostoperative myocardial infarction.


Instruction: How long did Walsh SR, Bhutta H, Tang TY, et al. say that anaesthetic specialisation leads to improved early-stage heart function?

Output: 48:117–22.52

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did Walsh SR, Bhutta H, Tang TY, et al. say that anaesthetic specialisation leads to improved early-stage heart function?. ### Response: 48:117–22.52.


Instruction: What leads to improved early- and medium-term survival after major vascularsurgery?

Output: Anaesthetic specialisation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What leads to improved early- and medium-term survival after major vascularsurgery?. ### Response: Anaesthetic specialisation.


Instruction: What year did Eur J Vasc Endovasc Surg. 2010:39:719–25.55?

Output: -term survival following major vascularsurgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Eur J Vasc Endovasc Surg. 2010:39:719–25.55?. ### Response: -term survival following major vascularsurgery.


Instruction: How did Hirai S. respond to systemic inflammatory response syndrome?

Output: after cardiacsurgery under cardiopulmonary bypass

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Hirai S. respond to systemic inflammatory response syndrome?. ### Response: after cardiacsurgery under cardiopulmonary bypass.


Instruction: What are microemboli from cardiopulmonary bypass associated with?

Output: a serum marker of brain injury

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are microemboli from cardiopulmonary bypass associated with?. ### Response: a serum marker of brain injury.


Instruction: What is a serum marker of?

Output: brain injury

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a serum marker of?. ### Response: brain injury.


Instruction: When did JExtra Corpor Technol. 2010;42:40–4.57?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did JExtra Corpor Technol. 2010;42:40–4.57?. ### Response: 2010.


Instruction: What is the incidence of cognitive dysfunction after coronary artery bypass graft surgery?

Output: The effects of cardiopulmonarybypass on the number of cerebral microemboli

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the incidence of cognitive dysfunction after coronary artery bypass graft surgery?. ### Response: The effects of cardiopulmonarybypass on the number of cerebral microemboli.


Instruction: What does Continuous-flow cell saver reduce?

Output: cognitive decline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Continuous-flow cell saver reduce?. ### Response: cognitive decline.


Instruction: What reduces cognitive decline in elderly patients after coronary bypasssurgery?

Output: Continuous-flow cell saver

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What reduces cognitive decline in elderly patients after coronary bypasssurgery?. ### Response: Continuous-flow cell saver.


Instruction: When did Circulation. 2007;116:1888–95.60?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circulation. 2007;116:1888–95.60?. ### Response: 2007.


Instruction: What is the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al 2020 ACC/AHA Guideline for the Management of Valvular Heart DiseaseFebruary 2, 2021 Circulation. 2021;143:e72–e227

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al 2020 ACC/AHA Guideline for the Management of Valvular Heart DiseaseFebruary 2, 2021 Circulation. 2021;143:e72–e227.


Instruction: What is an example of an intravascular catheter removal?

Output: infected focus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of an intravascular catheter removal?. ### Response: infected focus.


Instruction: How long does bac-teremia last?

Output: >4 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does bac-teremia last?. ### Response: >4 days.


Instruction: What is the risk of IE relatively low?

Output: In the absence of 1) prolonged bac-teremia lasting >4 days, 2) a permanent intra-cardiac device, 3) hemodialysis dependency, or 4) spinal infection or nonvertebral osteomyelitis, the risk of IE is relatively low, and routine TEE may not be necessary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of IE relatively low?. ### Response: In the absence of 1) prolonged bac-teremia lasting >4 days, 2) a permanent intra-cardiac device, 3) hemodialysis dependency, or 4) spinal infection or nonvertebral osteomyelitis, the risk of IE is relatively low, and routine TEE may not be necessary.


Instruction: What is routine TEE not necessary?

Output: the risk of IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is routine TEE not necessary?. ### Response: the risk of IE.


Instruction: Where are studies that support the recommendations summarized?

Output: Online Data Supplement 42

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are studies that support the recommendations summarized?. ### Response: Online Data Supplement 42.


Instruction: What is Online Data Supplement 42.COR LOE Recommendations1 B-NR1?

Output: Medical TherapyRecommendations for Medical Therapy for IEReferenced studies that support the recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Online Data Supplement 42.COR LOE Recommendations1 B-NR1?. ### Response: Medical TherapyRecommendations for Medical Therapy for IEReferenced studies that support the recommendations.


Instruction: What should be initiated and continued after blood cultures are obtained?

Output: antibiotic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be initiated and continued after blood cultures are obtained?. ### Response: antibiotic therapy.


Instruction: What should patients with suspected or confirmed IE associated with drug use be referred to for opioid substitution therapy?

Output: addiction treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients with suspected or confirmed IE associated with drug use be referred to for opioid substitution therapy?. ### Response: addiction treatment.


Instruction: What is reasonable in patients with IE and with evidence of cerebral embolism or stroke?

Output: temporarily discontinue anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable in patients with IE and with evidence of cerebral embolism or stroke?. ### Response: temporarily discontinue anticoagulation.


Instruction: What is it reasonable to temporarily discontinue anticoagulation?

Output: In patients with IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is it reasonable to temporarily discontinue anticoagulation?. ### Response: In patients with IE.


Instruction: What may be considered in patients with left-sided IE caused by streptococcus?

Output: stable

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered in patients with left-sided IE caused by streptococcus?. ### Response: stable.


Instruction: What may be considered if TEE before the switch to oral antibiotic therapy shows no paravalvular infection?

Output: a change to oral antibiotic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered if TEE before the switch to oral antibiotic therapy shows no paravalvular infection?. ### Response: a change to oral antibiotic therapy.


Instruction: What can be performed 1 to 3 days before the completion of the treatment?

Output: a follow-up TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be performed 1 to 3 days before the completion of the treatment?. ### Response: a follow-up TEE.


Instruction: What should be performed 1 to 3 days before the completion of the antibiotic course?

Output: a follow-up TEE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be performed 1 to 3 days before the completion of the antibiotic course?. ### Response: a follow-up TEE.


Instruction: What should patients with known VHD not receive before blood cultures?

Output: antibiotics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients with known VHD not receive before blood cultures?. ### Response: antibiotics.


Instruction: What should patients with known VHD not receive before blood cultures are obtained for unexplained fever?

Output: antibiotics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients with known VHD not receive before blood cultures are obtained for unexplained fever?. ### Response: antibiotics.


Instruction: What are the details of specific antimicrobial regimens published by the AHA, European Society of Cardiology, and British Society for Antimicrobial Che-motherapy?

Output: Synopsis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the details of specific antimicrobial regimens published by the AHA, European Society of Cardiology, and British Society for Antimicrobial Che-motherapy?. ### Response: Synopsis.


Instruction: What is a higher risk of intracranial bleeding in patients on anticoagulant therapy for AF or a mechani-cal heart valve?

Output: continued anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a higher risk of intracranial bleeding in patients on anticoagulant therapy for AF or a mechani-cal heart valve?. ### Response: continued anticoagulation.


Instruction: What does effective long-term therapy include in patients with suspected intravenous drug use?

Output: referral to an addiction treatment program

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does effective long-term therapy include in patients with suspected intravenous drug use?. ### Response: referral to an addiction treatment program.


Instruction: What does long-term therapy include?

Output: referral to an addiction treatment program

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does long-term therapy include?. ### Response: referral to an addiction treatment program.


Instruction: What may be possible to convert from intravenous to oral antibiotics in a select subset of patients?

Output: if TEE confirms the absence of paravalvu-lar extension of the infection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be possible to convert from intravenous to oral antibiotics in a select subset of patients?. ### Response: if TEE confirms the absence of paravalvu-lar extension of the infection.


Instruction: What is the most common type of surgical intervention?

Output: intravascular catheter removal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common type of surgical intervention?. ### Response: intravascular catheter removal.


Instruction: What type of therapy is used in addition to antibiotic therapy?

Output: early surgical intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is used in addition to antibiotic therapy?. ### Response: early surgical intervention.


Instruction: Atorvastatin versus Revasculariza-tion Treatment Investigators. Aggressive lipid-lowering therapyWhat is the 2011 ACCF/AHA/SCAI PCI Guideline e623Downloaded from http://ahajournals.org by on what date?

Output: May 1, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atorvastatin versus Revasculariza-tion Treatment Investigators. Aggressive lipid-lowering therapyWhat is the 2011 ACCF/AHA/SCAI PCI Guideline e623Downloaded from http://ahajournals.org by on what date?. ### Response: May 1, 2023.


Instruction: What type of artery is indicated to bypass the LAD artery?

Output: right internal mammary artery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of artery is indicated to bypass the LAD artery?. ### Response: right internal mammary artery.


Instruction: What is a second IMA used to graft the left circumflex or rightcoronary artery to?

Output: LV myocardium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a second IMA used to graft the left circumflex or rightcoronary artery to?. ### Response: LV myocardium.


Instruction: What is reasonable to improve the likelihood of survival and decrease reinterven-tion?

Output: use of asecond IMA to graft the left circumflex or rightcoronary artery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable to improve the likelihood of survival and decrease reinterven-tion?. ### Response: use of asecond IMA to graft the left circumflex or rightcoronary artery.


Instruction: When is a second IMA to graft the left circumflex or rightcoronary artery?

Output: when critically stenosed and per-fusing LV myocardium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is a second IMA to graft the left circumflex or rightcoronary artery?. ### Response: when critically stenosed and per-fusing LV myocardium.


Instruction: During the transition range, what are the causes of SCA and SCD in-clude a lower proportion of inherited diseases and in-creasing proportion of heart disease?

Output: from the mid-20s to the mid-30s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: During the transition range, what are the causes of SCA and SCD in-clude a lower proportion of inherited diseases and in-creasing proportion of heart disease?. ### Response: from the mid-20s to the mid-30s.


Instruction: What is the greatest challenge that has been made in risk prediction?

Output: to identify the relatively small, high-risk subgroups con-cealed within the large general population

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the greatest challenge that has been made in risk prediction?. ### Response: to identify the relatively small, high-risk subgroups con-cealed within the large general population.


Instruction: What is the greatest challenge in risk prediction of SCA and SCD?

Output: to identify the relatively small, high-risk subgroups con-cealed within the large general population

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the greatest challenge in risk prediction of SCA and SCD?. ### Response: to identify the relatively small, high-risk subgroups con-cealed within the large general population.


Instruction: What are the relatively small, high-risk subgroups con-cealed within the large general population?

Output: who have no identified disease but are at risk of SCA as their first cardiac event

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the relatively small, high-risk subgroups con-cealed within the large general population?. ### Response: who have no identified disease but are at risk of SCA as their first cardiac event.


Instruction: What are the cellular mechanisms of VA3.1?

Output: enhanced normal au-tomaticity, abnormal automaticity, triggered activ-ity induced by early or late afterdepolarizations, and reentry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the cellular mechanisms of VA3.1?. ### Response: enhanced normal au-tomaticity, abnormal automaticity, triggered activ-ity induced by early or late afterdepolarizations, and reentry.


Instruction: What is triggered activ-ity induced by early or late afterdepolarizations?

Output: abnormal automaticity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is triggered activ-ity induced by early or late afterdepolarizations?. ### Response: abnormal automaticity.


Instruction: Reentry requires what to initiate the arrhythmia?

Output: a trigger

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Reentry requires what to initiate the arrhythmia?. ### Response: a trigger.


Instruction: What is the substrate of a trig-ger?

Output: PVC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the substrate of a trig-ger?. ### Response: PVC.


Instruction: What may be due to automaticity?

Output: The trig-ger may be a PVC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be due to automaticity?. ### Response: The trig-ger may be a PVC.


Instruction: The substrate may be structural remodeling secondary to an underlying disease process and often includes what?

Output: a scar

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The substrate may be structural remodeling secondary to an underlying disease process and often includes what?. ### Response: a scar.


Instruction: What may alter the initiation or propagation of the cardiac action poten-tial?

Output: Changes in ion channel or transporter function and/or expression and cell to cell coupling secondary to the underlying pathology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may alter the initiation or propagation of the cardiac action poten-tial?. ### Response: Changes in ion channel or transporter function and/or expression and cell to cell coupling secondary to the underlying pathology.


Instruction: What is dynamically influenced by a variety of factors?

Output: The electrophysiological substrate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is dynamically influenced by a variety of factors?. ### Response: The electrophysiological substrate.


Instruction: What may arise from subordinate pacemaker cells in the His-Purkinje system?

Output: Enhanced automaticity or abnormal automaticity causing VA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may arise from subordinate pacemaker cells in the His-Purkinje system?. ### Response: Enhanced automaticity or abnormal automaticity causing VA.


Instruction: What is responsible for spontaneous phase 4 depolarization in the sinus node?

Output: An initiating current

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is responsible for spontaneous phase 4 depolarization in the sinus node?. ### Response: An initiating current.


Instruction: What is the rate determined by the integration of the maximum dia-stolic potential?

Output: at the end of repolarization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the rate determined by the integration of the maximum dia-stolic potential?. ### Response: at the end of repolarization.


Instruction: What is determined by the integration of the maximum dia-stolic potential at the end of repolarization, the slope of phase 4 depolarization and the threshold potential?

Output: The rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is determined by the integration of the maximum dia-stolic potential at the end of repolarization, the slope of phase 4 depolarization and the threshold potential?. ### Response: The rate.


Instruction: What arises from a par -tial depolarized membrane potential that is usually close to the activation potential for calcium channels in the body?

Output: abnormal automaticity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What arises from a par -tial depolarized membrane potential that is usually close to the activation potential for calcium channels in the body?. ### Response: abnormal automaticity.


Instruction: What is close to the activation potential for calcium channels in the cell membrane?

Output: par -tially depolarized membrane potential

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is close to the activation potential for calcium channels in the cell membrane?. ### Response: par -tially depolarized membrane potential.


Instruction: In the acute phase of an MI or during transient ischemia, what causes partial depolarization of the resting membrane potential?

Output: increased extracellular potassium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the acute phase of an MI or during transient ischemia, what causes partial depolarization of the resting membrane potential?. ### Response: increased extracellular potassium.


Instruction: What can injury currents initiate?

Output: spontaneous activity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can injury currents initiate?. ### Response: spontaneous activity.


Instruction: What may initiate spontaneous activity in ischemia?

Output: early or late afterdepolarizations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may initiate spontaneous activity in ischemia?. ### Response: early or late afterdepolarizations.


Instruction: What may occur in both tissue and healthy myocardium?

Output: injury currents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may occur in both tissue and healthy myocardium?. ### Response: injury currents.


Instruction: When did abnormal automaticity occur?

Output: a par -tially depolarized membrane potential that is usually close to the activation potential  for calcium channels in the cell membrane

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did abnormal automaticity occur?. ### Response: a par -tially depolarized membrane potential that is usually close to the activation potential  for calcium channels in the cell membrane.


Instruction: How much variation in three successive TC measurements?

Output: 18%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much variation in three successive TC measurements?. ### Response: 18%.


Instruction: F requent testing of lipid pr ofiles may lead to what?

Output: over- diagnosis and an increas ed number of patients who receive unnecessary  treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: F requent testing of lipid pr ofiles may lead to what?. ### Response: over- diagnosis and an increas ed number of patients who receive unnecessary  treatment.


Instruction: Evidence suggests annual lipid testing, when compared to testing every three years?

Output: results in unnecessa ry treatment in 7 per  every  1,000 patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Evidence suggests annual lipid testing, when compared to testing every three years?. ### Response: results in unnecessa ry treatment in 7 per  every  1,000 patients.


Instruction: How many patients need unnecessary treatment per 1,000 patients?

Output: 7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients need unnecessary treatment per 1,000 patients?. ### Response: 7.


Instruction: How often should testing be conducted to eliminate false positives and false negatives?

Output: frequent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often should testing be conducted to eliminate false positives and false negatives?. ### Response: frequent.


Instruction: What is unclear how frequently testing should be conducted?

Output: to eliminate false positives and false negatives

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is unclear how frequently testing should be conducted?. ### Response: to eliminate false positives and false negatives.


Instruction: What is a relatively minor contributor to CV?

Output: cholesterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a relatively minor contributor to CV?. ### Response: cholesterol.


Instruction: What did Perera et al. (2015) find the true variation from testing exceeds?

Output: the random variation from repeated testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Perera et al. (2015) find the true variation from testing exceeds?. ### Response: the random variation from repeated testing.


Instruction: What is a relatively minor contributor to CV risk scores compared to other patient characteristics?

Output: cholesterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a relatively minor contributor to CV risk scores compared to other patient characteristics?. ### Response: cholesterol.


Instruction: What supports longer testing int ervals?

Output: cholesterol is a relatively minor contributor to CV risk scores

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What supports longer testing int ervals?. ### Response: cholesterol is a relatively minor contributor to CV risk scores.


Instruction: Most of the change in CV risk over time is because of the development or change in what?

Output: risk factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Most of the change in CV risk over time is because of the development or change in what?. ### Response: risk factors.


Instruction: What is the name of the study that investigated the role of cardiac catheterization in morbidly obese patients?

Output: Catheter Cardiovasc Interv.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the role of cardiac catheterization in morbidly obese patients?. ### Response: Catheter Cardiovasc Interv..


Instruction: What was the title of the paper that looked at the relationship between renal dysfunction and cardiovascular outcomes after myoca rdialinfarction?

Output: Arterial Revascularization Therapies Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the title of the paper that looked at the relationship between renal dysfunction and cardiovascular outcomes after myoca rdialinfarction?. ### Response: Arterial Revascularization Therapies Study.


Instruction: What is the name of the science advisory from the American Heart AssociationKidney And Cardiovascular Disease Council?

Output: Detection of chronickidney disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the science advisory from the American Heart AssociationKidney And Cardiovascular Disease Council?. ### Response: Detection of chronickidney disease.


Instruction: What are the Councils on HighBlood Pressure Research and Epidemiology and Prevention?

Output: Cardiovascular Disease in the Young

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Councils on HighBlood Pressure Research and Epidemiology and Prevention?. ### Response: Cardiovascular Disease in the Young.


Instruction: What group was developed in collaboration with the National Kidney Foundation?

Output: Quality of Care and OutcomesResearch Interdisciplinary Working Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What group was developed in collaboration with the National Kidney Foundation?. ### Response: Quality of Care and OutcomesResearch Interdisciplinary Working Group.


Instruction: What year did Circulation. 2006;114:1083–7.1183?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Circulation. 2006;114:1083–7.1183?. ### Response: 2006.


Instruction: What is a risk factor for the development of cardiovascular disease?

Output: Kidney disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for the development of cardiovascular disease?. ### Response: Kidney disease.


Instruction: What is the name of the group that has a statement on kidney disease in CardiovascularDisease?

Output: American Heart Association Councils

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that has a statement on kidney disease in CardiovascularDisease?. ### Response: American Heart Association Councils.


Instruction: What is one of the topics covered in CardiovascularDisease, High Blood Pressure Research, Clinical Cardiology, and Ep-idemology and Prevention?

Output: Kidney disease as a riskfactor for development of cardiovascular disease: a statement from theAmerican Heart Association Councils on Kidney

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the topics covered in CardiovascularDisease, High Blood Pressure Research, Clinical Cardiology, and Ep-idemology and Prevention?. ### Response: Kidney disease as a riskfactor for development of cardiovascular disease: a statement from theAmerican Heart Association Councils on Kidney.


Instruction: Circulation. 2003;108:2154–69.1185.

Output: Comparative survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation. 2003;108:2154–69.1185.. ### Response: Comparative survival.


Instruction: What does Renal function-based contrastdosing do?

Output: to define safe limits of radiographic contrast media in patientsundergoing percutaneous coronary interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Renal function-based contrastdosing do?. ### Response: to define safe limits of radiographic contrast media in patientsundergoing percutaneous coronary interventions.


Instruction: What are K/DOQI clinical practice guidelines for chronic kidney disease?

Output: eval-uation, classification, and stratification

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are K/DOQI clinical practice guidelines for chronic kidney disease?. ### Response: eval-uation, classification, and stratification.


Instruction: What are the K/DOQI clinical practice guidelines for chronic kidney disease?

Output: eval-uation, classification, and stratification

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the K/DOQI clinical practice guidelines for chronic kidney disease?. ### Response: eval-uation, classification, and stratification.


Instruction: When did the Am J Kidney Dis. 2002 issue 39:S1–266.1187?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Am J Kidney Dis. 2002 issue 39:S1–266.1187?. ### Response: 2002.


Instruction: What is the impact of diabetes on dialysispatients in the United States?

Output: Comparative survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact of diabetes on dialysispatients in the United States?. ### Response: Comparative survival.


Instruction: What is the impact of artery bypass surgery on diabetes?

Output: Comparative survival of dialysispatients in the United States

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact of artery bypass surgery on diabetes?. ### Response: Comparative survival of dialysispatients in the United States.


Instruction: When was Circulation.106:2207-11.1188?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Circulation.106:2207-11.1188?. ### Response: 2002.


Instruction: What is a comparison of clinicaloutcomes of coronary bypass grafting and percutaneo ustransluminal coronary angioplasty in renal dialysis patients?

Output: Koyanagi

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a comparison of clinicaloutcomes of coronary bypass grafting and percutaneo ustransluminal coronary angioplasty in renal dialysis patients?. ### Response: Koyanagi.


Instruction: What is the difference between percutaneous coronary intervention and coronary artery bypass grafting in diabetic nephropathy?

Output: a single center experience

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between percutaneous coronary intervention and coronary artery bypass grafting in diabetic nephropathy?. ### Response: a single center experience.


Instruction: What are the results of the Arterial Revascularization Therapies Study?

Output: Association of chronic kidneydisease with clinical outcomes after coronary revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of the Arterial Revascularization Therapies Study?. ### Response: Association of chronic kidneydisease with clinical outcomes after coronary revascularization.


Instruction: What does ARTS stand for?

Output: Arterial Revascularization Therapies Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ARTS stand for?. ### Response: Arterial Revascularization Therapies Study.


Instruction: What is the name of the study with clinical outcomes after coronary revascularization?

Output: Arterial Revascularization Therapies Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study with clinical outcomes after coronary revascularization?. ### Response: Arterial Revascularization Therapies Study.


Instruction: How many patients with kidney disease survive aftercoronary re-vascularization in 2004?

Output: 110:1890–5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with kidney disease survive aftercoronary re-vascularization in 2004?. ### Response: 110:1890–5.


Instruction: Why may therapy be considered?

Output: the risk of rupture

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why may therapy be considered?. ### Response: the risk of rupture.


Instruction: What is often urgently necessary and may be lifesaving in patients with IE?

Output: Cardiovascular surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is often urgently necessary and may be lifesaving in patients with IE?. ### Response: Cardiovascular surgery.


Instruction: When are decisions regarding surgical intervention best made?

Output: when individualized

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When are decisions regarding surgical intervention best made?. ### Response: when individualized.


Instruction: What are the most common reasons for surgical management of IE?

Output: congestive heart failure, progressive valve dysfunction, and embolic phenomena

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the most common reasons for surgical management of IE?. ### Response: congestive heart failure, progressive valve dysfunction, and embolic phenomena.


Instruction: What is a prediction of an individual patient’s risk for embolization Documented Bartonella?

Output: initially culture negative, determined to be positive by nonculture tests

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a prediction of an individual patient’s risk for embolization Documented Bartonella?. ### Response: initially culture negative, determined to be positive by nonculture tests.


Instruction: What is a risk factor for embolization?

Output: gentamicin cannot be given, then replace it with rifampin 600 mg/d PO/IV in 2 equally divided doses  plus  gentamicin sulfate 3 mg·kg−1·d−1 IV/IM in 3 equally divided dosesPediatric dosage: Ceftriaxone 100 mg·kg−1·d−1 IV/IM once daily; gentamicin 3 mg·kg−1·d−1 IV/IM in 3 equally divided doses; doxycycline 2–4 mg·kg−1·d−1 IV/PO in 2 equally divided doses; rifampin 20 mg·kg−1·d−1 PO/IV in 2 equally divided doses2As discussed in the text, these recommendations are based on consensus of experts and not experimental comparative studies ( Class IIa; Level of Evidence C). Note: Pediatric dosage should not exceed that of a normal adult

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for embolization?. ### Response: gentamicin cannot be given, then replace it with rifampin 600 mg/d PO/IV in 2 equally divided doses  plus  gentamicin sulfate 3 mg·kg−1·d−1 IV/IM in 3 equally divided dosesPediatric dosage: Ceftriaxone 100 mg·kg−1·d−1 IV/IM once daily; gentamicin 3 mg·kg−1·d−1 IV/IM in 3 equally divided doses; doxycycline 2–4 mg·kg−1·d−1 IV/PO in 2 equally divided doses; rifampin 20 mg·kg−1·d−1 PO/IV in 2 equally divided doses2As discussed in the text, these recommendations are based on consensus of experts and not experimental comparative studies ( Class IIa; Level of Evidence C). Note: Pediatric dosage should not exceed that of a normal adult.


Instruction: How is Bartonella determined to be positive?

Output: nonculture tests

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is Bartonella determined to be positive?. ### Response: nonculture tests.


Instruction: What is the dose of gentamicin that cannot be given?

Output: 3 mg·kg−

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the dose of gentamicin that cannot be given?. ### Response: 3 mg·kg−.


Instruction: What is the pediatric dosage of Ceftriaxone?

Output: 100 mg·kg−1·d−1 IV/IM once daily

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the pediatric dosage of Ceftriaxone?. ### Response: 100 mg·kg−1·d−1 IV/IM once daily.


Instruction: How many equally divided doses is rifampin?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many equally divided doses is rifampin?. ### Response: 2.


Instruction: What is gentamicin sulfate 3 mgkg1d1 IV/IM?

Output: 3 equally divided doses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is gentamicin sulfate 3 mgkg1d1 IV/IM?. ### Response: 3 equally divided doses.


Instruction: What is the recommended dose of doxycycline?

Output: 200 mg/d IV or PO

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommended dose of doxycycline?. ### Response: 200 mg/d IV or PO.


Instruction: How many equally divided doses of rifampin are there?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many equally divided doses of rifampin are there?. ### Response: 2.


Instruction: What are the recommendations based on?

Output: consensus of experts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the recommendations based on?. ### Response: consensus of experts.


Instruction: What should not exceed that of a normal adult?

Output: Pediatric dosage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not exceed that of a normal adult?. ### Response: Pediatric dosage.


Instruction: What indicates intramuscular?

Output: IM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates intramuscular?. ### Response: IM.


Instruction: IV, intravenous; LOE, level of evidence; and PO, oral?

Output: IV

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: IV, intravenous; LOE, level of evidence; and PO, oral?. ### Response: IV.


Instruction: What does Table 7 provide for empirical treatment of native valve infective endocarditis?

Output: vancomycin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Table 7 provide for empirical treatment of native valve infective endocarditis?. ### Response: vancomycin.


Instruction: What is appropriate dosing of gentamicin?

Output: 3 mg·kg−1·

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is appropriate dosing of gentamicin?. ### Response: 3 mg·kg−1·.


Instruction: What does hs-CRP stand for?

Output: protein

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does hs-CRP stand for?. ### Response: protein.


Instruction: What is the risk of hemorrhagic stroke?

Output: LDL cholesterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of hemorrhagic stroke?. ### Response: LDL cholesterol.


Instruction: How many trials were compared to statin ther-apy with a control?

Output: 31

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many trials were compared to statin ther-apy with a control?. ### Response: 31.


Instruction: What was the OR of total stroke?

Output: 0.84

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the OR of total stroke?. ### Response: 0.84.


Instruction: What is the 95% CI of ICH?

Output: 0.86–1.41

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 95% CI of ICH?. ### Response: 0.86–1.41.


Instruction: Which meta-analysis found that statins were not associated with an increase in ICH risk?

Output: another meta-analysis that included 23 randomized trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which meta-analysis found that statins were not associated with an increase in ICH risk?. ### Response: another meta-analysis that included 23 randomized trials.


Instruction: What did not correlate with risk of ICH?

Output: The intensity of cholesterol lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did not correlate with risk of ICH?. ### Response: The intensity of cholesterol lowering.


Instruction: What is most likely related to their capacity to reduce progression or to induce regression of atherosclerosis?

Output: The beneficial effect of statins on ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is most likely related to their capacity to reduce progression or to induce regression of atherosclerosis?. ### Response: The beneficial effect of statins on ischemic stroke.


Instruction: What does statin therapy slow the progression of?

Output: carotid IMT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does statin therapy slow the progression of?. ### Response: carotid IMT.


Instruction: What does LDL cholesterol reduction correlate inversely with?

Output: the progression of carotid IMT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does LDL cholesterol reduction correlate inversely with?. ### Response: the progression of carotid IMT.


Instruction: Why are beneficial effects on carotid IMT greater with statin?

Output: plaque char -acteristics appear to improve with statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why are beneficial effects on carotid IMT greater with statin?. ### Response: plaque char -acteristics appear to improve with statin therapy.


Instruction: What are the carotid IMT greater with higher-intensity statin therapy?

Output: beneficial effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the carotid IMT greater with higher-intensity statin therapy?. ### Response: beneficial effects.


Instruction: What do plaque char -acteristics appear to improve with?

Output: statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do plaque char -acteristics appear to improve with?. ### Response: statin therapy.


Instruction: How did one study report that intensive lipid ther -apy depleted?

Output: high-resolution MRI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did one study report that intensive lipid ther -apy depleted?. ### Response: high-resolution MRI.


Instruction: High-dose atorvastatin reduced what?

Output: carotid plaque inflammation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: High-dose atorvastatin reduced what?. ### Response: carotid plaque inflammation.


Instruction: What should be prescribed in accordance with the 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults?

Output: Statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be prescribed in accordance with the 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults?. ### Response: Statins.


Instruction: The 2013 guidelines represent a dramatic shift away from what?

Output: specific LDL cholesterol targets

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The 2013 guidelines represent a dramatic shift away from what?. ### Response: specific LDL cholesterol targets.


Instruction: What does the guidelines call for instead of LDL cholesterol targets?

Output: esti-mating the 10-year risk for atherosclerotic CVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the guidelines call for instead of LDL cholesterol targets?. ### Response: esti-mating the 10-year risk for atherosclerotic CVD.


Instruction: What is the 10-year risk for atherosclerotic CVD?

Output: esti-mating the 10-year risk for atherosclerotic CVD and, based on the estimated risk, prescribing a statin at low, moderate, or high intensity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 10-year risk for atherosclerotic CVD?. ### Response: esti-mating the 10-year risk for atherosclerotic CVD and, based on the estimated risk, prescribing a statin at low, moderate, or high intensity.


Instruction: How does the intensity of statin therapy depend on the drug and dose?

Output: The intensity of statin therapy depends on the drug and the dose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does the intensity of statin therapy depend on the drug and dose?. ### Response: The intensity of statin therapy depends on the drug and the dose.


Instruction: What is lovastatin at 20 mg/d considered?

Output: con-sidered low-intensity therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is lovastatin at 20 mg/d considered?. ### Response: con-sidered low-intensity therapy.


Instruction: At what dose is atorvastatin considered high-intensity therapy?

Output: 80 mg/d

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: At what dose is atorvastatin considered high-intensity therapy?. ### Response: 80 mg/d.


Instruction: What is the cardiovascu-lar risk calculator?

Output: cvriskcalculator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cardiovascu-lar risk calculator?. ### Response: cvriskcalculator.


Instruction: What is the name of the cardiovascu-lar risk calculator?

Output: cvriskcalculator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the cardiovascu-lar risk calculator?. ### Response: cvriskcalculator.


Instruction: Where can a 10-year risk calculator be found?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can a 10-year risk calculator be found?. ### Response: http://my.americanheart.org/cvriskcalculator.


Instruction: What are the values for total cholesterol and HDL included in?

Output: cardiovascular risk calculator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the values for total cholesterol and HDL included in?. ### Response: cardiovascular risk calculator.


Instruction: How many lipid-lowering trials did a meta-analysis of?

Output: 78

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many lipid-lowering trials did a meta-analysis of?. ### Response: 78.


Instruction: How many patients reported that statins decreased the risk of ischemic stroke?

Output: 266 973

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients reported that statins decreased the risk of ischemic stroke?. ### Response: 266 973.


Instruction: How many patients reported that statins decreased the risk of total stroke?

Output: 266 973

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients reported that statins decreased the risk of total stroke?. ### Response: 266 973.


Instruction: Baddour et al Infective Endocarditis in Adults 1439With the guidance of the “diagnostic floor,” a number of these cases were reclassified as what?

Output: rejected for IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Baddour et al Infective Endocarditis in Adults 1439With the guidance of the “diagnostic floor,” a number of these cases were reclassified as what?. ### Response: rejected for IE.


Instruction: No patients developed IE during the subsequent 12 weeks?

Output: Follow-up in these reclassified patients documented the specificity of this diagnostic schema because no patients developed IE during the subsequent 12 weeks of observation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No patients developed IE during the subsequent 12 weeks?. ### Response: Follow-up in these reclassified patients documented the specificity of this diagnostic schema because no patients developed IE during the subsequent 12 weeks of observation.


Instruction: Why did no patients develop IE during the subsequent 12 weeks of observation?

Output: With the guidance of the “diagnostic floor,” a number of these cases were reclassified as rejected for IE.24 Follow-up in these reclassified patients documented the specificity of this diagnostic schema

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why did no patients develop IE during the subsequent 12 weeks of observation?. ### Response: With the guidance of the “diagnostic floor,” a number of these cases were reclassified as rejected for IE.24 Follow-up in these reclassified patients documented the specificity of this diagnostic schema.


Instruction: How many patients are involved in the current literature?

Output: nearly 2000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients are involved in the current literature?. ### Response: nearly 2000.


Instruction: What criteria should patients suspected of having IE be evaluated for?

Output: Duke criteria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What criteria should patients suspected of having IE be evaluated for?. ### Response: Duke criteria.


Instruction: What was originally developed to facilitate epidemiological and clinical research efforts?

Output: cri-teria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was originally developed to facilitate epidemiological and clinical research efforts?. ### Response: cri-teria.


Instruction: What was the primary diagnostic schema of the Duke criteria?

Output: modified Duke criteria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary diagnostic schema of the Duke criteria?. ### Response: modified Duke criteria.


Instruction: What is IE a heterogeneous disease with highly variable outcomes?

Output: clinical presentations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is IE a heterogeneous disease with highly variable outcomes?. ### Response: clinical presentations.


Instruction: What has been somewhat more difficult than extending Duke criteria to the clinical practice setting?

Output: Duke cri-teria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been somewhat more difficult than extending Duke criteria to the clinical practice setting?. ### Response: Duke cri-teria.


Instruction: Full application of Duke criteria requires what?

Output: detailed clinical, microbiological, radiological, and echocardiographic queries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Full application of Duke criteria requires what?. ### Response: detailed clinical, microbiological, radiological, and echocardiographic queries.


Instruction: What is IE a heterogeneous disease with highly variable clinical presentations?

Output: IE is a heterogeneous disease with highly variable clinical presentations, the use of these criteria alone will never suffice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is IE a heterogeneous disease with highly variable clinical presentations?. ### Response: IE is a heterogeneous disease with highly variable clinical presentations, the use of these criteria alone will never suffice.


Instruction: What do criteria changes that add sensitivity often do at the expense of specificity?

Output: IE is a heterogeneous disease with highly variable clinical presentations, the use of these criteria alone will never suffice. Criteria changes that add sensitivity often do so at the expense of specificity and vice versa

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do criteria changes that add sensitivity often do at the expense of specificity?. ### Response: IE is a heterogeneous disease with highly variable clinical presentations, the use of these criteria alone will never suffice. Criteria changes that add sensitivity often do so at the expense of specificity and vice versa.


Instruction: The Duke criteria are meant to be what?

Output: a guide for diag-nosing IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The Duke criteria are meant to be what?. ### Response: a guide for diag-nosing IE.


Instruction: What are meant to be a guide for diagnosing IE and must not replace clinical judgment?

Output: The Duke criteria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are meant to be a guide for diagnosing IE and must not replace clinical judgment?. ### Response: The Duke criteria.


Instruction: What may appropriately and wisely decide whether or not to treat an individual patient?

Output: Clinicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may appropriately and wisely decide whether or not to treat an individual patient?. ### Response: Clinicians.


Instruction: What are the Duke criteria for definite or possible IE?

Output: Tables 2 and 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Duke criteria for definite or possible IE?. ### Response: Tables 2 and 3.


Instruction: What will the modifications of Duke criteria help investigators who wish to examine?

Output: the clinical and epidemiological features of IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will the modifications of Duke criteria help investigators who wish to examine?. ### Response: the clinical and epidemiological features of IE.


Instruction: What do these modifications require for patients who are hospitalized in both community-based and tertiary care hospitals?

Output: fur -ther validation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do these modifications require for patients who are hospitalized in both community-based and tertiary care hospitals?. ### Response: fur -ther validation.


Instruction: What are patients rejected as having because they did not meet the minimal floor criteria?

Output: IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients rejected as having because they did not meet the minimal floor criteria?. ### Response: IE.


Instruction: What is the minimum floor criteria for possible IE?

Output: Duke criteria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the minimum floor criteria for possible IE?. ### Response: Duke criteria.


Instruction: What must be made as soon as possible to initiate appropriate empirical antibiotic therapy?

Output: The diagnosis of IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must be made as soon as possible to initiate appropriate empirical antibiotic therapy?. ### Response: The diagnosis of IE.


Instruction: What can be best managed by early surgery?

Output: patients at high risk for complications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be best managed by early surgery?. ### Response: patients at high risk for complications.


Instruction: In cases with a high suspicion of IE based on the clinical picture or the patient’s risk fac-tor profile, such as injection drug use, what is another focus?

Output: car

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In cases with a high suspicion of IE based on the clinical picture or the patient’s risk fac-tor profile, such as injection drug use, what is another focus?. ### Response: car.


Instruction: What is the Algorithm: Management of Dyslipidemia for Cardiovascular Risk Reduction?

Output: Recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Algorithm: Management of Dyslipidemia for Cardiovascular Risk Reduction?. ### Response: Recommendations.


Instruction: What are the Recommendations?

Output: Algorithm: Management of Dyslipidemia for Cardiovascular Risk Reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Recommendations?. ### Response: Algorithm: Management of Dyslipidemia for Cardiovascular Risk Reduction.


Instruction: How many b. Secondary Prevention?

Output: 56

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many b. Secondary Prevention?. ### Response: 56.


Instruction: What c. Othe r Medications, Supplements, and Nutraceuticals?

Output: 32

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What c. Othe r Medications, Supplements, and Nutraceuticals?. ### Response: 32.


Instruction: How many C. Lifestyle Interventions?

Output: 47

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many C. Lifestyle Interventions?. ### Response: 47.


Instruction: What does Primary Prevention compare to?

Output: Secondary Prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Primary Prevention compare to?. ### Response: Secondary Prevention.


Instruction: What does Secondary Prevention compare with?

Output: Medical Therapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Secondary Prevention compare with?. ### Response: Medical Therapies.


Instruction: How does Primary prevention compare to Secondary prevention?

Output: 56

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does Primary prevention compare to Secondary prevention?. ### Response: 56.


Instruction: What could be the reason for the smaller RR reduction noted in SHARP?

Output: lower compliance to study drug

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could be the reason for the smaller RR reduction noted in SHARP?. ### Response: lower compliance to study drug.


Instruction: What could be due to lower compliance to study drug in the subgroup of dialysispatients?

Output: smaller RR reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could be due to lower compliance to study drug in the subgroup of dialysispatients?. ### Response: smaller RR reduction.


Instruction: Dialysis patients showed on average a 0.60 mmol/l(23 mg/dl) LDL-C reduction in comparison to the non-dialysis CKD group?

Output: weak

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Dialysis patients showed on average a 0.60 mmol/l(23 mg/dl) LDL-C reduction in comparison to the non-dialysis CKD group?. ### Response: weak.


Instruction: How much does LDL-C decrease in dialysis patients?

Output: 0.96 mmol/l (37 mg/dl

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much does LDL-C decrease in dialysis patients?. ### Response: 0.96 mmol/l (37 mg/dl.


Instruction: What does the Work Group believe is not recom-mend for most HD patients in the United States?

Output: initiation of statin treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Work Group believe is not recom-mend for most HD patients in the United States?. ### Response: initiation of statin treatment.


Instruction: What is not recommended for most prevalent HD patients?

Output: initiation of statin treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended for most prevalent HD patients?. ### Response: initiation of statin treatment.


Instruction: What might patients reasonably choose if they are interested in a relatively small, uncertain reduction incardiovascular events?

Output: statin treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What might patients reasonably choose if they are interested in a relatively small, uncertain reduction incardiovascular events?. ### Response: statin treatment.


Instruction: What may be more inclined to receive a statin, recognizing that the benefit remains uncertain?

Output: 47patients who meet this criterion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be more inclined to receive a statin, recognizing that the benefit remains uncertain?. ### Response: 47patients who meet this criterion.


Instruction: Recent MI or greaterlife expectancy favor what type of treatment?

Output: treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Recent MI or greaterlife expectancy favor what type of treatment?. ### Response: treatment.


Instruction: More severecomorbidity or higher current pill burden favorwhat type oftreatment?

Output: non-treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: More severecomorbidity or higher current pill burden favorwhat type oftreatment?. ### Response: non-treatment.


Instruction: What is the current pill burden?

Output: favoringnon-treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the current pill burden?. ### Response: favoringnon-treatment.


Instruction: What do we suggest in patients already receiving statins or statin/ezetimibecombination at the time of dialysis?

Output: these agents be continued

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do we suggest in patients already receiving statins or statin/ezetimibecombination at the time of dialysis?. ### Response: these agents be continued.


Instruction: What percentage of SHARP patients without kidney failure at baseline began dialysis during the trial and were analyzed in thenon-dialysis group?

Output: 2141(34%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of SHARP patients without kidney failure at baseline began dialysis during the trial and were analyzed in thenon-dialysis group?. ### Response: 2141(34%).


Instruction: What is it reasonable tocontinue statins?

Output: if they areinterested in a relatively small, uncertain reduction incardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is it reasonable tocontinue statins?. ### Response: if they areinterested in a relatively small, uncertain reduction incardiovascular events.


Instruction: What does the Work Group consider it to be reasonable to continue statins in patients who are already receiving themat the time of dialysis initiation?

Output: themagnitude of clinical beneﬁt may be lower than in patientswith non-dialysis-dependent CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Work Group consider it to be reasonable to continue statins in patients who are already receiving themat the time of dialysis initiation?. ### Response: themagnitude of clinical beneﬁt may be lower than in patientswith non-dialysis-dependent CKD.


Instruction: What may be lower than in patients with non-dialysis-dependent CKD?

Output: agnitude of clinical beneﬁt

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be lower than in patients with non-dialysis-dependent CKD?. ### Response: agnitude of clinical beneﬁt.


Instruction: Physicians should periodically review the clinical status of what patients and revisit the decision?

Output: dialysispatients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Physicians should periodically review the clinical status of what patients and revisit the decision?. ### Response: dialysispatients.


Instruction: What is a graded weak recommendation for statin treatment?

Output: Discontinuation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a graded weak recommendation for statin treatment?. ### Response: Discontinuation.


Instruction: What may bewarranted in patients who place a low value on a small potential relative?

Output: Discontinuation of statin or statin/ezetimibe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may bewarranted in patients who place a low value on a small potential relative?. ### Response: Discontinuation of statin or statin/ezetimibe.


Instruction: What do kidney transplant recipients place a low value on?

Output: asmall potential relative reduction in cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do kidney transplant recipients place a low value on?. ### Response: asmall potential relative reduction in cardiovascular events.


Instruction: What does a high value on the risks of polypharmacy and drug toxicity place on the patients?

Output: uncertain

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does a high value on the risks of polypharmacy and drug toxicity place on the patients?. ### Response: uncertain.


Instruction: In adult transplant recipients, we suggest what?

Output: treatment with a statin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In adult transplant recipients, we suggest what?. ### Response: treatment with a statin.


Instruction: What is the name of the 2018 ACHD GuidelineCirculation?

Output: Stout et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2018 ACHD GuidelineCirculation?. ### Response: Stout et al.


Instruction: How many people with congenital heart disease have a biopsychosocial experience?

Output: 20–33 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people with congenital heart disease have a biopsychosocial experience?. ### Response: 20–33 years.


Instruction: What is a review of the literature?

Output: Biopsychosocial experiences of adults with congenital heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a review of the literature?. ### Response: Biopsychosocial experiences of adults with congenital heart disease.


Instruction: How long did the follow-up on psychosocial functioning of the adult with congenital heart disease last?

Output: 20–33 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the follow-up on psychosocial functioning of the adult with congenital heart disease last?. ### Response: 20–33 years.


Instruction: What did the Eur Heart J. 2003:24:673-83?

Output: Psychosocial functioning of the adult with congenital heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Eur Heart J. 2003:24:673-83?. ### Response: Psychosocial functioning of the adult with congenital heart disease.


Instruction: How long was the follow up on psychological func-tioning in adults with congenced heart disease?

Output: 20–33 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the follow up on psychological func-tioning in adults with congenced heart disease?. ### Response: 20–33 years.


Instruction: Who wrote the systematic review?

Output: Callus E, Quadri E, Ricci C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote the systematic review?. ### Response: Callus E, Quadri E, Ricci C.


Instruction: What is the name of the systematic review in adults with congenital heart disease?

Output: Update on psychological func-tioning

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review in adults with congenital heart disease?. ### Response: Update on psychological func-tioning.


Instruction: What was the title of the review in 2013?

Output: Expert Rev Cardiovasc Ther

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the title of the review in 2013?. ### Response: Expert Rev Cardiovasc Ther.


Instruction: How did Amianto F, Bergui G, Abbate-Daga G, et al. grow up with?

Output: a congenital heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Amianto F, Bergui G, Abbate-Daga G, et al. grow up with?. ### Response: a congenital heart disease.


Instruction: When was Panminerva Med published?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Panminerva Med published?. ### Response: 2011.


Instruction: What is a meta-analysis in children and adolescents with congenital heart disease?

Output: Psychological and cogni-tive functioning

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a meta-analysis in children and adolescents with congenital heart disease?. ### Response: Psychological and cogni-tive functioning.


Instruction: What is the outcome after surgical repair of congenital cardiac malformations at school age?

Output: Late neurodevelopmental outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the outcome after surgical repair of congenital cardiac malformations at school age?. ### Response: Late neurodevelopmental outcome.


Instruction: What is a meta-analysis?

Output: Psychological and cogni-tive functioning in children and adolescents with congenital heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a meta-analysis?. ### Response: Psychological and cogni-tive functioning in children and adolescents with congenital heart disease.


Instruction: What did Flynn TB, Clancy RR, et al. do after repair of total anomalous pulmonary venous connec-tion?

Output: Late neurodevelopmental outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Flynn TB, Clancy RR, et al. do after repair of total anomalous pulmonary venous connec-tion?. ### Response: Late neurodevelopmental outcome.


Instruction: What was the J Thorac Cardiovasc Surg. 2005;129:1091–7.

Output: Late neurodevelopmental outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the J Thorac Cardiovasc Surg. 2005;129:1091–7.. ### Response: Late neurodevelopmental outcome.


Instruction: What did Sananes R, Manlhiot C, Kelly E do after open heart operations?

Output: Neurodevelopmental out-comes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Sananes R, Manlhiot C, Kelly E do after open heart operations?. ### Response: Neurodevelopmental out-comes.


Instruction: What is the name of the apolipoprotein that has been validated?

Output: E ε2 allele

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the apolipoprotein that has been validated?. ### Response: E ε2 allele.


Instruction: How old are the children with congenital heart disease?

Output: 7-12

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old are the children with congenital heart disease?. ### Response: 7-12.


Instruction: What are the characteristics of adolescents with heart disease that are characterized by psychological adjustment and quality of life?

Output: Neurodevelopmental outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the characteristics of adolescents with heart disease that are characterized by psychological adjustment and quality of life?. ### Response: Neurodevelopmental outcome.


Instruction: What allele is associated with neurodevelopmental dysfunction after cardiac surgery in neonates and infants?

Output: apolipoprotein E ε2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What allele is associated with neurodevelopmental dysfunction after cardiac surgery in neonates and infants?. ### Response: apolipoprotein E ε2.


Instruction: What year did Arrington CB, Lipkin PH, Newburger JW, et al. publish a study on the validity of association of the apolipoprotein E 2 allele?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Arrington CB, Lipkin PH, Newburger JW, et al. publish a study on the validity of association of the apolipoprotein E 2 allele?. ### Response: 2014.


Instruction: In what year was the J Thorac Cardiovasc Surg published?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was the J Thorac Cardiovasc Surg published?. ### Response: 2014.


Instruction: What is the scientific statement from the American Heart Association about children with congenital heart disease?

Output: Neurodevelopmental outcomes in children with congenital heart disease: evaluation and management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the scientific statement from the American Heart Association about children with congenital heart disease?. ### Response: Neurodevelopmental outcomes in children with congenital heart disease: evaluation and management.


Instruction: What was the Circulation. 2012;126:1143–72.

Output: Neurodevelopmental outcomes in children with congenital heart disease: evaluation and management: a scientific statement from the American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the Circulation. 2012;126:1143–72.. ### Response: Neurodevelopmental outcomes in children with congenital heart disease: evaluation and management: a scientific statement from the American Heart Association.


Instruction: What did Cassidy AR, White MT, DeMaso DR, et al. study?

Output: Executive function in chil-dren and adolescents with critical cyanotic congenital heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Cassidy AR, White MT, DeMaso DR, et al. study?. ### Response: Executive function in chil-dren and adolescents with critical cyanotic congenital heart disease.


Instruction: What is the name of the 2015 AHA/ACC guideline for the management of patients with valvular heart disease?

Output: ACHD GuidelineCirculation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2015 AHA/ACC guideline for the management of patients with valvular heart disease?. ### Response: ACHD GuidelineCirculation.


Instruction: What is the acronym for the Registry of Pregnancy and Cardiac disease?

Output: ROPAC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the Registry of Pregnancy and Cardiac disease?. ### Response: ROPAC.


Instruction: What are the names of the registry that tracks pregnancy outcomes in women with cardiovascular disease over 10 years?

Output: ESC Registry Of Pregnancy And Cardiac disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the registry that tracks pregnancy outcomes in women with cardiovascular disease over 10 years?. ### Response: ESC Registry Of Pregnancy And Cardiac disease.


Instruction: What is the name of the registry that provides data on pregnancy outcomes?

Output: ESC Registry Of Pregnancy And Cardiac disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the registry that provides data on pregnancy outcomes?. ### Response: ESC Registry Of Pregnancy And Cardiac disease.


Instruction: When was the registry of pregnancy and cardiac data released?

Output: April 27, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the registry of pregnancy and cardiac data released?. ### Response: April 27, 2023.


Instruction: What does QALY stand for?

Output: quality-adjusted life-years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does QALY stand for?. ### Response: quality-adjusted life-years.


Instruction: What is WHO-CHOICE?

Output: World Health Organization Choosing Interventions that are Cost-Effective

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is WHO-CHOICE?. ### Response: World Health Organization Choosing Interventions that are Cost-Effective.


Instruction: When was the file downloaded?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the file downloaded?. ### Response: April 28, 2023.


Instruction: What should be performed for UA/NSTEMI patients in which an initial conservative strategy is selected and no subsequent features appear that would necessitate diagnostic angiography?

Output: a stresstest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be performed for UA/NSTEMI patients in which an initial conservative strategy is selected and no subsequent features appear that would necessitate diagnostic angiography?. ### Response: a stresstest.


Instruction: What should be performed if the patient is classified as not at low risk?

Output: diagnostic angiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be performed if the patient is classified as not at low risk?. ### Response: diagnostic angiography.


Instruction: What should a stresstest be performed for?

Output: UA/NSTEMI patients in whom an initial conservative strategy is selected and no subsequent features appear thatwould necessitate diagnostic angiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should a stresstest be performed for?. ### Response: UA/NSTEMI patients in whom an initial conservative strategy is selected and no subsequent features appear thatwould necessitate diagnostic angiography.


Instruction: What is the level of evidence that a patient is at low risk?

Output: A

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the level of evidence that a patient is at low risk?. ### Response: A.


Instruction: What should the patient do if they are classified as low risk after stress testing?

Output: the instructions noted below should be followed inpreparation for discharge

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should the patient do if they are classified as low risk after stress testing?. ### Response: the instructions noted below should be followed inpreparation for discharge.


Instruction: How long can the patient continue clopidogrel or ticagrelor*?

Output: up to 12 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long can the patient continue clopidogrel or ticagrelor*?. ### Response: up to 12 months.


Instruction: How long is the duration of hospitalization?

Output: 8 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the duration of hospitalization?. ### Response: 8 days.


Instruction: What is the level of evidence for IV GP IIb/IIIa inhibitor?

Output: B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the level of evidence for IV GP IIb/IIIa inhibitor?. ### Response: B.


Instruction: How long does UFH last?

Output: 48 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does UFH last?. ### Response: 48 hours.


Instruction: What is the duration of hospitalization?

Output: up to 8 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the duration of hospitalization?. ### Response: up to 8 days.


Instruction: What should be followed for UA/NSTEMI patients in whom CABG is selected as a postangiography management strategy?

Output: the instructions notedbelow

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be followed for UA/NSTEMI patients in whom CABG is selected as a postangiography management strategy?. ### Response: the instructions notedbelow.


Instruction: What is the IV GP IIb/IIIa inhibitor?

Output: eptifibatide or tirofiban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the IV GP IIb/IIIa inhibitor?. ### Response: eptifibatide or tirofiban.


Instruction: What should be managed as follows?

Output: Anticoagulant therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be managed as follows?. ### Response: Anticoagulant therapy.


Instruction: How long before CABG should enoxaparin be discontinued?

Output: 12 to 24 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long before CABG should enoxaparin be discontinued?. ### Response: 12 to 24 hours.


Instruction: How long before CABG should you discontinue fondaparinux?

Output: 24 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long before CABG should you discontinue fondaparinux?. ### Response: 24 hours.


Instruction: How many hours prior to CABG do patients discontinue bivalirudin?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many hours prior to CABG do patients discontinue bivalirudin?. ### Response: 3.


Instruction: What is the level of evidence in patients taking P2Y12receptor inhibitors?

Output: B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the level of evidence in patients taking P2Y12receptor inhibitors?. ### Response: B.