Instruction: What is a target BP of 140/90 mm Hg?

Output: The clinical trial evidence is strongest for a target BP of 140/90 mm Hg in this population

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a target BP of 140/90 mm Hg?. ### Response: The clinical trial evidence is strongest for a target BP of 140/90 mm Hg in this population.


Instruction: What would benefit from BP control earlier in life?

Output: these individuals often have a high lifetime risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would benefit from BP control earlier in life?. ### Response: these individuals often have a high lifetime risk.


Instruction: What should be assessed at every healthcare visit for tobacco use?

Output: All adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be assessed at every healthcare visit for tobacco use?. ### Response: All adults.


Instruction: What should all adults who use tobacco be firmly advised to do to achieve tobacco abstinence?

Output: quit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should all adults who use tobacco be firmly advised to do to achieve tobacco abstinence?. ### Response: quit.


Instruction: What was the focus of the 2015 ACC/AHA/SCAI Focused Update on Primary PCI 1145Appendix 3?

Output: Reviewer Relationships With Industry and Other Entities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the focus of the 2015 ACC/AHA/SCAI Focused Update on Primary PCI 1145Appendix 3?. ### Response: Reviewer Relationships With Industry and Other Entities.


Instruction: What did Levine et al focus on in 2015?

Output: Primary PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Levine et al focus on in 2015?. ### Response: Primary PCI.


Instruction: Who were the reviewers from 2011 PCI and 2013 STEMI Guidelines?

Output: Combined Peer Reviewers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who were the reviewers from 2011 PCI and 2013 STEMI Guidelines?. ### Response: Combined Peer Reviewers.


Instruction: What are the 2011 PCI and 2013 STEMI Guidelines?

Output: Combined Peer Reviewers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the 2011 PCI and 2013 STEMI Guidelines?. ### Response: Combined Peer Reviewers.


Instruction: Who is the official reviewer at AHA Harvard Medical School?

Output: Christopher P. Cannon

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the official reviewer at AHA Harvard Medical School?. ### Response: Christopher P. Cannon.


Instruction: Who is the official reviewer for the AHA Harvard Medical School?

Output: Christopher P. Cannon

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the official reviewer for the AHA Harvard Medical School?. ### Response: Christopher P. Cannon.


Instruction: What is the name of the ACC/AHA Task Force on Clinical Practice Guidelines?

Output: Jeffrey L. Anderson

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the ACC/AHA Task Force on Clinical Practice Guidelines?. ### Response: Jeffrey L. Anderson.


Instruction: Who is a professor of medicine at Brigham and Women’s Hospital?

Output: Christopher P. Cannon

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a professor of medicine at Brigham and Women’s Hospital?. ### Response: Christopher P. Cannon.


Instruction: Who is a Clinical Professor of Medicine at Oregon Health & Science University?

Output: Joaquin E. Cigarroa

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a Clinical Professor of Medicine at Oregon Health & Science University?. ### Response: Joaquin E. Cigarroa.


Instruction: Who is the Director of Cardiovascular Innovation at Mount Sinai Medical Center?

Output: Abbott

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Director of Cardiovascular Innovation at Mount Sinai Medical Center?. ### Response: Abbott.


Instruction: What is the name of the official reviewer at Northwestern University Feinberg?

Output: Kirk N. Garratt

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the official reviewer at Northwestern University Feinberg?. ### Response: Kirk N. Garratt.


Instruction: Who is the official reviewer of Northwestern University Feinberg School of Medicine?

Output: Kirk N. Garratt

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the official reviewer of Northwestern University Feinberg School of Medicine?. ### Response: Kirk N. Garratt.


Instruction: What is the name of the person who is the Associate Chair of Quality and Research at the Hofstra University Medical School?

Output: Kirk N. Garratt

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the person who is the Associate Chair of Quality and Research at the Hofstra University Medical School?. ### Response: Kirk N. Garratt.


Instruction: Who is the official reviewer for the University of Washington Medical Center?

Output: Steven L. Goldberg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the official reviewer for the University of Washington Medical Center?. ### Response: Steven L. Goldberg.


Instruction: What is the name of the professor of medicine at Vancouver Hospital Research Pavilion?

Output: G. B. John Mancini

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor of medicine at Vancouver Hospital Research Pavilion?. ### Response: G. B. John Mancini.


Instruction: Where is the profesional reviewer of Sanofi-aventis?

Output: Bristol-Myers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the profesional reviewer of Sanofi-aventis?. ### Response: Bristol-Myers.


Instruction: What is the name of the professor of medicine and cardiology at the University of California Los Angeles?

Output: Jonathan M. Tobis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor of medicine and cardiology at the University of California Los Angeles?. ### Response: Jonathan M. Tobis.


Instruction: Who is a member of the ACC/AHA Task Force on Clinical Practice Guidelines?

Output: Joaquin E. Cigarroa

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a member of the ACC/AHA Task Force on Clinical Practice Guidelines?. ### Response: Joaquin E. Cigarroa.


Instruction: What is the acronym for the American Heart Association?

Output: American College ofCardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the American Heart Association?. ### Response: American College ofCardiology.


Instruction: What does the acronym ACCF/AHAclinical practice guideline methodology summit report?

Output: American College of Cardiology Founda-tion/American Heart Association Task Force on PracticeGuidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the acronym ACCF/AHAclinical practice guideline methodology summit report?. ### Response: American College of Cardiology Founda-tion/American Heart Association Task Force on PracticeGuidelines.


Instruction: What is the name of the summit report?

Output: American College of Cardiology Founda-tion/American Heart Association Task Force on PracticeGuidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the summit report?. ### Response: American College of Cardiology Founda-tion/American Heart Association Task Force on PracticeGuidelines.


Instruction: How long have ACC/AHA clinical practice guidelines been evolving?

Output: 30-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long have ACC/AHA clinical practice guidelines been evolving?. ### Response: 30-year.


Instruction: What task force did the American College of Cardiology/American Heart Association Task Force onPractice Guidelines report on?

Output: The evolutionand future of ACC/AHA clinical practice guidelines: a 30-year journey

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What task force did the American College of Cardiology/American Heart Association Task Force onPractice Guidelines report on?. ### Response: The evolutionand future of ACC/AHA clinical practice guidelines: a 30-year journey.


Instruction: What was the name of the Task Force report on Clinical Practice Guidelines?

Output: American College of Cardiology/American Heart Asso-ciation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the Task Force report on Clinical Practice Guidelines?. ### Response: American College of Cardiology/American Heart Asso-ciation.


Instruction: What is the acronym for the American Heart Association Task Force on Clinical Practice Guidelines?

Output: American College ofCardiology/American Heart Association Task Force onPractice Guidelines. J Am Coll Cardiol. 2014;64:1373 –84.8.Halperin JL, Levine GN, Al-Khatib SM, et al. Furtherevolution of the ACC/AHA clinical practice guidelinerecommendation classi ﬁcation system: a report of theAmerican College of Cardiology/American Heart Asso-ciation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the American Heart Association Task Force on Clinical Practice Guidelines?. ### Response: American College ofCardiology/American Heart Association Task Force onPractice Guidelines. J Am Coll Cardiol. 2014;64:1373 –84.8.Halperin JL, Levine GN, Al-Khatib SM, et al. Furtherevolution of the ACC/AHA clinical practice guidelinerecommendation classi ﬁcation system: a report of theAmerican College of Cardiology/American Heart Asso-ciation.


Instruction: When was the J Am Coll Cardiol. 2015 published?

Output: September 23, 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol. 2015 published?. ### Response: September 23, 2015.


Instruction: Who wrote the 2011ACCF/AHA/SCAI guideline?

Output: Levine GN, Bates ER, Blankenship JC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote the 2011ACCF/AHA/SCAI guideline?. ### Response: Levine GN, Bates ER, Blankenship JC.


Instruction: What is the ACCF/AHA guideline for the management of ST-elevation myocardial infarction a report of the American College of Cardiology Foundation/AmericanHeart Association Task Force on Practice Guidelines?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ACCF/AHA guideline for the management of ST-elevation myocardial infarction a report of the American College of Cardiology Foundation/AmericanHeart Association Task Force on Practice Guidelines?. ### Response: 2013.


Instruction: What are the names of the Society for Car-diovascular Angiography and Interventions?

Output: American College of Car-diology Foundation/American Heart Association TaskForce

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the Society for Car-diovascular Angiography and Interventions?. ### Response: American College of Car-diology Foundation/American Heart Association TaskForce.


Instruction: What is the name of the Task Force on Practice Guidelines?

Output: American College of Cardiology Foundation/AmericanHeart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Practice Guidelines?. ### Response: American College of Cardiology Foundation/AmericanHeart Association.


Instruction: What are the names of the two groups?

Output: AmericanHeart Association, American College of Cardiology, andU.S. Department of Health and Human Services

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the two groups?. ### Response: AmericanHeart Association, American College of Cardiology, andU.S. Department of Health and Human Services.


Instruction: How many patients with multivessel disease are treated with a cardiac catheterization?

Output: 58:e44 –122.10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with multivessel disease are treated with a cardiac catheterization?. ### Response: 58:e44 –122.10.


Instruction: What did the APEX-AMI trial provide insights from?

Output: Non-culprit coronary artery percutaneous coronary inter-vention during acute ST-segment elevation myocardialinfarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the APEX-AMI trial provide insights from?. ### Response: Non-culprit coronary artery percutaneous coronary inter-vention during acute ST-segment elevation myocardialinfarction.


Instruction: What is the difference between culpritvessel only and multivessel and staged percuta-neous coronary intervention?

Output: Culprit vessel percutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between culpritvessel only and multivessel and staged percuta-neous coronary intervention?. ### Response: Culprit vessel percutaneous coronary intervention.


Instruction: What is a pairwise and network meta-analysis?

Output: ivessel and staged percuta-neous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a pairwise and network meta-analysis?. ### Response: ivessel and staged percuta-neous coronary intervention.


Instruction: When was the J Am Coll Cardiol 58:692 –703.14.

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol 58:692 –703.14.. ### Response: 2011.


Instruction: What is one of the outcomes of non-infarct artery intervention during primary percuta-neous coronary intervention for ST-segment elevationmyocardial infarction?

Output: Prevalence, predictors, and in-hospital

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the outcomes of non-infarct artery intervention during primary percuta-neous coronary intervention for ST-segment elevationmyocardial infarction?. ### Response: Prevalence, predictors, and in-hospital.


Instruction: How many performance measures are proposed as part of this initial AHA/ASA clinical performance measure set for adults hospitalized with ICH?

Output: Nine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many performance measures are proposed as part of this initial AHA/ASA clinical performance measure set for adults hospitalized with ICH?. ### Response: Nine.


Instruction: How many of these measures are either existing performance measures that are NQF endorsed or have analogous performance measures through other organizations?

Output: Six

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many of these measures are either existing performance measures that are NQF endorsed or have analogous performance measures through other organizations?. ### Response: Six.


Instruction: How many measures are endorsed for immediate use?

Output: 6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many measures are endorsed for immediate use?. ### Response: 6.


Instruction: How many new measures are proposed?

Output: Three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many new measures are proposed?. ### Response: Three.


Instruction: What did the writing group recognize that there are many issues that might be desirable in performance measures but do not meet the criteria for inclusion in this set?

Output: performance mea-sures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the writing group recognize that there are many issues that might be desirable in performance measures but do not meet the criteria for inclusion in this set?. ### Response: performance mea-sures.


Instruction: What kind of standards do performance measures currently not meet?

Output: high evidence standards

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What kind of standards do performance measures currently not meet?. ### Response: high evidence standards.


Instruction: What type of recommendations are required for consideration?

Output: Class I or III

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of recommendations are required for consideration?. ### Response: Class I or III.


Instruction: At what stage are quality assessment and performance measure implementation in stroke?

Output: early stage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: At what stage are quality assessment and performance measure implementation in stroke?. ### Response: early stage.


Instruction: What is hoped to lead to revisions and expansions of the evidence base for ICH care?

Output: future advancement of the evidence base for ICH care and broader experience with testing and implementation of performance measures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hoped to lead to revisions and expansions of the evidence base for ICH care?. ### Response: future advancement of the evidence base for ICH care and broader experience with testing and implementation of performance measures.


Instruction: What is the ulti-mate goal of improving the care of patients with ICH and stroke?

Output: Quality assessment and performance measure implementation in stroke are still at an early stage, and it is hoped that future advancement of the evidence base for ICH care and broader experience with testing and implementation of performance measures will lead to revisions and expansions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ulti-mate goal of improving the care of patients with ICH and stroke?. ### Response: Quality assessment and performance measure implementation in stroke are still at an early stage, and it is hoped that future advancement of the evidence base for ICH care and broader experience with testing and implementation of performance measures will lead to revisions and expansions.


Instruction: What is the name of the journal that was downloaded from http://ahajournals.org by on April 28, 2023?

Output: ahajournals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that was downloaded from http://ahajournals.org by on April 28, 2023?. ### Response: ahajournals.


Instruction: What are the 2019 AHA/ACC High Blood Pressure Performance and Quality Measures called?

Output: Cardiovasc Qual Outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the 2019 AHA/ACC High Blood Pressure Performance and Quality Measures called?. ### Response: Cardiovasc Qual Outcomes.


Instruction: What is the DOI of the measure for the Diagnosis and Management of HBP in Outpatient Care Setting?

Output: 10.1161/HCQ.0000000000000057

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the DOI of the measure for the Diagnosis and Management of HBP in Outpatient Care Setting?. ### Response: 10.1161/HCQ.0000000000000057.


Instruction: What is the name of the measure that harmonises with the current performance measure?

Output: Controlling High Blood Pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the measure that harmonises with the current performance measure?. ### Response: Controlling High Blood Pressure.


Instruction: What is ACC/AHA stage 2 HBP?

Output: Controlling High Blood Pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ACC/AHA stage 2 HBP?. ### Response: Controlling High Blood Pressure.


Instruction: What measure for ACC/AHA stage 2 HBP is currently in widespread use?

Output: Controlling High Blood Pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What measure for ACC/AHA stage 2 HBP is currently in widespread use?. ### Response: Controlling High Blood Pressure.


Instruction: What is the current performance measure for ACC/AHA stage 2 HBP?

Output: Controlling High Blood Pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the current performance measure for ACC/AHA stage 2 HBP?. ### Response: Controlling High Blood Pressure.


Instruction: What is added lower target for further risk reduction?

Output: Healthcare provider

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is added lower target for further risk reduction?. ### Response: Healthcare provider.


Instruction: What is the current performance measure for ACC/AHA stage 2 HBP currently in widespread use?

Output: Controlling High Blood Pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the current performance measure for ACC/AHA stage 2 HBP currently in widespread use?. ### Response: Controlling High Blood Pressure.


Instruction: What is added emphasis on?

Output: high-quality evidence and strong recommendation for promoting lifestyle modification

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is added emphasis on?. ### Response: high-quality evidence and strong recommendation for promoting lifestyle modification.


Instruction: What is the ACC/AHA stage 2 and stage 1 HBP control SBP 130 mm Hg?

Output: PM-1b

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ACC/AHA stage 2 and stage 1 HBP control SBP 130 mm Hg?. ### Response: PM-1b.


Instruction: What is a composite measure combining PM-1b and PM-2?

Output: Controlling High Blood Pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a composite measure combining PM-1b and PM-2?. ### Response: Controlling High Blood Pressure.


Instruction: What measure is currently in widespread use for ACC/AHA stage 2 HBP?

Output: Controlling High Blood Pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What measure is currently in widespread use for ACC/AHA stage 2 HBP?. ### Response: Controlling High Blood Pressure.


Instruction: Adds emphasis on including what?

Output: ACC/AHA stage 1 HBP population

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Adds emphasis on including what?. ### Response: ACC/AHA stage 1 HBP population.


Instruction: Combines both ACC and AHA stage 1 and what other population?

Output: HBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Combines both ACC and AHA stage 1 and what other population?. ### Response: HBP.


Instruction: What is the performance measure for ACC/AHA stage 2 HBP currently in widespread use?

Output: Controlling High Blood Pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the performance measure for ACC/AHA stage 2 HBP currently in widespread use?. ### Response: Controlling High Blood Pressure.


Instruction: In what year was a strong recommendation for promoting lifestyle modification recommended?

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was a strong recommendation for promoting lifestyle modification recommended?. ### Response: 2017.


Instruction: What is recommended in the 2017 Hypertension Clinical Practice Guidelines for this population?

Output: promoting lifestyle modification

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended in the 2017 Hypertension Clinical Practice Guidelines for this population?. ### Response: promoting lifestyle modification.


Instruction: What is used for management of ACC/AHA stage 2 HBP?

Output: HBPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used for management of ACC/AHA stage 2 HBP?. ### Response: HBPM.


Instruction: What is the name of the organization that harmonises with current performance measure?

Output: Healthcare provider

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that harmonises with current performance measure?. ### Response: Healthcare provider.


Instruction: What is a health plan?

Output: clinically integrated network

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a health plan?. ### Response: clinically integrated network.


Instruction: What is the name of the 2017 VA/SCD GuidelineCirculation study?

Output: Al-Khatib

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2017 VA/SCD GuidelineCirculation study?. ### Response: Al-Khatib.


Instruction: What is available online for the purposes of full transparency?

Output: writing committee members’ compre-hensive disclosure information

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is available online for the purposes of full transparency?. ### Response: writing committee members’ compre-hensive disclosure information.


Instruction: What is available online for the Task Force?

Output: comprehensive disclosure information

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is available online for the Task Force?. ### Response: comprehensive disclosure information.


Instruction: What does the writing committee use when developing recommendations?

Output: evidence-based methodologies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the writing committee use when developing recommendations?. ### Response: evidence-based methodologies.


Instruction: Literature searches focus on what?

Output: randomized controlled trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Literature searches focus on what?. ### Response: randomized controlled trials.


Instruction: What are RCTs?

Output: randomized controlled trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are RCTs?. ### Response: randomized controlled trials.


Instruction: What is an independent evidence review committee called?

Output: ERC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an independent evidence review committee called?. ### Response: ERC.


Instruction: When is an ERC commissioned?

Output: when there are  ≥1 questions deemed of utmost clinical importance that merit formal systematic review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is an ERC commissioned?. ### Response: when there are  ≥1 questions deemed of utmost clinical importance that merit formal systematic review.


Instruction: What type of review is needed to determine which patients are most likely to benefit from a test, med-ication, device, or treatment strategy?

Output: systematic review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of review is needed to determine which patients are most likely to benefit from a test, med-ication, device, or treatment strategy?. ### Response: systematic review.


Instruction: What are the criteria for commissioning an ERC and formal systematic review?

Output: ≥1 questions deemed of utmost clinical importance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the criteria for commissioning an ERC and formal systematic review?. ### Response: ≥1 questions deemed of utmost clinical importance.


Instruction: What is the absence of a current authoritative systematic review?

Output: Criteria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the absence of a current authoritative systematic review?. ### Response: Criteria.


Instruction: The feasibility of defining the ben-efit and risk in a time frame consistent with writing a guideline?

Output: 2018;138:e272–e391

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The feasibility of defining the ben-efit and risk in a time frame consistent with writing a guideline?. ### Response: 2018;138:e272–e391.


Instruction: What do ERC members include?

Output: methodologists, epidemiologists, healthcare providers, and biostatisticians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do ERC members include?. ### Response: methodologists, epidemiologists, healthcare providers, and biostatisticians.


Instruction: What are the recom-mendations marked with when a formal systematic review has been commissioned?

Output: magnitude and certainty of benefit in proportion to risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the recom-mendations marked with when a formal systematic review has been commissioned?. ### Response: magnitude and certainty of benefit in proportion to risk.


Instruction: What is the basis of the systematic review marked with?

Output: SR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the basis of the systematic review marked with?. ### Response: SR.


Instruction: What does GDMT encompass?

Output: clinical evaluation, diagnostic test-ing, and pharmacological and procedural treatments

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does GDMT encompass?. ### Response: clinical evaluation, diagnostic test-ing, and pharmacological and procedural treatments.


Instruction: The reader should confirm the dosage by what?

Output: review-ing product insert material

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The reader should confirm the dosage by what?. ### Response: review-ing product insert material.


Instruction: What are the rec-ommendations limited to?

Output: medications, devices, and treatments approved for clinical use in the United States

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the rec-ommendations limited to?. ### Response: medications, devices, and treatments approved for clinical use in the United States.


Instruction: What indicates the strength of the recommendation?

Output: Class of Recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates the strength of the recommendation?. ### Response: Class of Recommendation.


Instruction: What measures the esti-mated magnitude and certainty of benefit in proportion to risk?

Output: Class of Recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What measures the esti-mated magnitude and certainty of benefit in proportion to risk?. ### Response: Class of Recommendation.


Instruction: The Level of Evidence (LOE) rates the quality of scientific evidence that supports the intervention on the basis of the type, quantity, and consistency of data from clinical trials and other sources?

Output: Table 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The Level of Evidence (LOE) rates the quality of scientific evidence that supports the intervention on the basis of the type, quantity, and consistency of data from clinical trials and other sources?. ### Response: Table 1.


Instruction: What is the name of the ACC/AHA Task Force on Clinical Practice Guidelines?

Output: Glenn N. Levine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the ACC/AHA Task Force on Clinical Practice Guidelines?. ### Response: Glenn N. Levine.


Instruction: What is the BP thresh-old for initiating drug treatment?

Output: there is no evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the BP thresh-old for initiating drug treatment?. ### Response: there is no evidence.


Instruction: What are the recommendations for management of hypertension during pregnancy?

Output: methyldopa, nifedipine, and/or labetalolS10.2.2-1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the recommendations for management of hypertension during pregnancy?. ### Response: methyldopa, nifedipine, and/or labetalolS10.2.2-1.


Instruction: How does lowering BP differ for women versus men?

Output: BP thresh-old for initiating drug treatment, the treatment target, the choice of initial antihypertensive medication, or the combina-tion of medications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does lowering BP differ for women versus men?. ### Response: BP thresh-old for initiating drug treatment, the treatment target, the choice of initial antihypertensive medication, or the combina-tion of medications.


Instruction: What is a potential limitation of RCTs?

Output: they are not specifically powered to determine the value of inten-sive SBP reduction in subgroups

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a potential limitation of RCTs?. ### Response: they are not specifically powered to determine the value of inten-sive SBP reduction in subgroups.


Instruction: Women are not specifically powered to determine the value of inten-sive SBP reduction in subgroups, including women in the case of what?

Output: SPRINT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Women are not specifically powered to determine the value of inten-sive SBP reduction in subgroups, including women in the case of what?. ### Response: SPRINT.


Instruction: In prespecified analyses, there was no evidence of an interaction between sex and what?

Output: treatment effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In prespecified analyses, there was no evidence of an interaction between sex and what?. ### Response: treatment effect.


Instruction: In a large meta-analysis, how many RCTs were there with about 100 000 men and 90 000 women with hypertension?

Output: 31

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In a large meta-analysis, how many RCTs were there with about 100 000 men and 90 000 women with hypertension?. ### Response: 31.


Instruction: How many women have hypertension?

Output: 90 000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many women have hypertension?. ### Response: 90 000.


Instruction: What type of trial has been called for to assess the effects of intensive SBP reduction in women?

Output: SPRINT-like trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of trial has been called for to assess the effects of intensive SBP reduction in women?. ### Response: SPRINT-like trial.


Instruction: In meta-analyses, there was no convincing evidence that different antihyperten-sive drug classes exerted sex-related differences in BP low-ering or provided distinct CVD protection?

Output: SPRINT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In meta-analyses, there was no convincing evidence that different antihyperten-sive drug classes exerted sex-related differences in BP low-ering or provided distinct CVD protection?. ### Response: SPRINT.


Instruction: What did sex-related differences in BP low-ering or provide distinct CVD protection?

Output: different antihyperten-sive drug classes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did sex-related differences in BP low-ering or provide distinct CVD protection?. ### Response: different antihyperten-sive drug classes.


Instruction: What offered slightly greater benefits for stroke preven-tion than did ACE inhibitors for women than for men?

Output: Calcium antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What offered slightly greater benefits for stroke preven-tion than did ACE inhibitors for women than for men?. ### Response: Calcium antagonists.


Instruction: Calcium antagonists reduced all-cause deaths compared with placebo in men but not in women?

Output: Calcium antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Calcium antagonists reduced all-cause deaths compared with placebo in men but not in women?. ### Response: Calcium antagonists.


Instruction: What did the Heart Attack Trial and Hypertension Care Computing Project report that beta blockers were associated with reduced mor-tality in men but not in women?

Output: low event rates in women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Heart Attack Trial and Hypertension Care Computing Project report that beta blockers were associated with reduced mor-tality in men but not in women?. ### Response: low event rates in women.


Instruction: Why was reduced mor -tality found in men but not in women?

Output: low event rates in women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was reduced mor -tality found in men but not in women?. ### Response: low event rates in women.


Instruction: Why was this finding likely due to low event rates?

Output: large number of statistical comparisons that were performed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was this finding likely due to low event rates?. ### Response: large number of statistical comparisons that were performed.


Instruction: In the open-label Second Australian National BP study, a significant reduction in CVD events was demonstrated in women with what?

Output: hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the open-label Second Australian National BP study, a significant reduction in CVD events was demonstrated in women with what?. ### Response: hypertension.


Instruction: What did women have a higher incidence of with ACE inhibitor-induced cough and edema with calcium antagonists than in men?

Output: A higher incidence of ACE inhibitor–induced cough

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did women have a higher incidence of with ACE inhibitor-induced cough and edema with calcium antagonists than in men?. ### Response: A higher incidence of ACE inhibitor–induced cough.


Instruction: What were the adverse effects of antihypertensive therapy twice as often in women as in men in the TOMHS study?

Output: A higher incidence of ACE inhibitor–induced cough and of edema with calcium antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the adverse effects of antihypertensive therapy twice as often in women as in men in the TOMHS study?. ### Response: A higher incidence of ACE inhibitor–induced cough and of edema with calcium antagonists.


Instruction: Who was more likely to experience hypoka-lemia and hyponatremia?

Output: Women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was more likely to experience hypoka-lemia and hyponatremia?. ### Response: Women.


Instruction: What was less likely to have gout with diuretics?

Output: Women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was less likely to have gout with diuretics?. ### Response: Women.


Instruction: Hypertension in pregnancy has special require-ments?

Output: recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hypertension in pregnancy has special require-ments?. ### Response: recommendations.


Instruction: PregnancyReferences that support recommendations are summarized in Online Data Supplement 53.COR LOE RecommendationsI C-LD1 What should women with hypertension who become pregnant transition to during pregnancy?

Output: methyldopa, nifedipine, and/or labetalolS10.2.2-1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: PregnancyReferences that support recommendations are summarized in Online Data Supplement 53.COR LOE RecommendationsI C-LD1 What should women with hypertension who become pregnant transition to during pregnancy?. ### Response: methyldopa, nifedipine, and/or labetalolS10.2.2-1.


Instruction: What was the panel unable to make a judgment on?

Output: harms and burdens of 4-factor PCC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the panel unable to make a judgment on?. ### Response: harms and burdens of 4-factor PCC.


Instruction: What was not available because of the lack of a suitable comparator group?

Output: 4-factorPCC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not available because of the lack of a suitable comparator group?. ### Response: 4-factorPCC.


Instruction: What percentage of patients receiving 4-factor PCC had bleeding either worsened or didn't improve?

Output: 32%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients receiving 4-factor PCC had bleeding either worsened or didn't improve?. ### Response: 32%.


Instruction: What did the panel not make a judgment on?

Output: harms and burdens

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the panel not make a judgment on?. ### Response: harms and burdens.


Instruction: What did the lack of evidence leave the net health benefit/harm of using 4-factorPCC as an addition to cessation of direct Xa inhibitors very uncertain?

Output: efficacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the lack of evidence leave the net health benefit/harm of using 4-factorPCC as an addition to cessation of direct Xa inhibitors very uncertain?. ### Response: efficacy.


Instruction: What is very uncertain about Xa inhibitors?

Output: net health benefit/harm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is very uncertain about Xa inhibitors?. ### Response: net health benefit/harm.


Instruction: What does the ASH guideline panel suggest for patients with life-threatening bleeding during treatment of VTE?

Output: either 4-factor PCCadministration as an addition to temporary cessation of oral direct Xainhibitor or cessation of oral direct Xa inhibitor alone be used

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the ASH guideline panel suggest for patients with life-threatening bleeding during treatment of VTE?. ### Response: either 4-factor PCCadministration as an addition to temporary cessation of oral direct Xainhibitor or cessation of oral direct Xa inhibitor alone be used.


Instruction: What is a conditional recommendation based on very low certainty in the evidence?

Output: inactivated-zhzo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a conditional recommendation based on very low certainty in the evidence?. ### Response: inactivated-zhzo.


Instruction: What would likely be the deciding factors in a life-threatening situation?

Output: the experience and judgmentof the prescriber weighing individual risks and benefits

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would likely be the deciding factors in a life-threatening situation?. ### Response: the experience and judgmentof the prescriber weighing individual risks and benefits.


Instruction: Why does this recommendation not apply tonon-life-threatening bleeding?

Output: cost likely outweighs potentialbenefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why does this recommendation not apply tonon-life-threatening bleeding?. ### Response: cost likely outweighs potentialbenefit.


Instruction: What is likely a small but quantifiable increase in risk ofthromboembolism associated with administration of PCC?

Output: life-threatening bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is likely a small but quantifiable increase in risk ofthromboembolism associated with administration of PCC?. ### Response: life-threatening bleeding.


Instruction: What clinical parameters define the need for intervention with 4-factorPCC over withholding oral direct Xa inhibitor alone?

Output: Harms and burden

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What clinical parameters define the need for intervention with 4-factorPCC over withholding oral direct Xa inhibitor alone?. ### Response: Harms and burden.


Instruction: What is 4-factor PCC in real-world patientspresenting with potentially life-threatening oral direct Xa inhibitor-associated bleeding?

Output: comparative effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is 4-factor PCC in real-world patientspresenting with potentially life-threatening oral direct Xa inhibitor-associated bleeding?. ### Response: comparative effectiveness.


Instruction: What does the ASH guideline panel suggest for patients with life threatening bleeding during oral directXainhibitor treatment of VT E?

Output: using coagulation factor Xa (recombinant), inactivated-zhzo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the ASH guideline panel suggest for patients with life threatening bleeding during oral directXainhibitor treatment of VT E?. ### Response: using coagulation factor Xa (recombinant), inactivated-zhzo.


Instruction: What is a recombinant coagulation factor Xa?

Output: recombinant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a recombinant coagulation factor Xa?. ### Response: recombinant.


Instruction: What is an inactivated-zhzo?

Output: condi-tional recommendation based on very low certainty in the evi-dence about effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an inactivated-zhzo?. ### Response: condi-tional recommendation based on very low certainty in the evi-dence about effects.


Instruction: What is the name of the coagulationfactor Xa?

Output: recombinant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the coagulationfactor Xa?. ### Response: recombinant.


Instruction: What does the guideline panel not recommend?

Output: 1 approach over the other

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the guideline panel not recommend?. ### Response: 1 approach over the other.


Instruction: How many systematic reviews did we find that addressed this question?

Output: no

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many systematic reviews did we find that addressed this question?. ### Response: no.


Instruction: What was the name of the single study that measured outcomes for patients receiving direct Xa inhibitors who were experiencing major bleeding?

Output: 4-factorPCC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the single study that measured outcomes for patients receiving direct Xa inhibitors who were experiencing major bleeding?. ### Response: 4-factorPCC.


Instruction: What is the risk of cardiovascular disease in women with migraine?

Output: 282. Kurth T, Schürks M, Logroscino G, Buring JE. Migraine frequency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of cardiovascular disease in women with migraine?. ### Response: 282. Kurth T, Schürks M, Logroscino G, Buring JE. Migraine frequency.


Instruction: What are the symptoms of migraine in women?

Output: migraine features, and cardio-vascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the symptoms of migraine in women?. ### Response: migraine features, and cardio-vascular disease.


Instruction: Who is the author of Migraine and Cardiovascular Disease?

Output: Kurth T

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of Migraine and Cardiovascular Disease?. ### Response: Kurth T.


Instruction: What did Kase CS, Schürks M, Kurth T study in the Women's Health Study?

Output: Migraine and cardiovascular disease in women and the role of aspirin: subgroup analyses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Kase CS, Schürks M, Kurth T study in the Women's Health Study?. ### Response: Migraine and cardiovascular disease in women and the role of aspirin: subgroup analyses.


Instruction: What is the role of aspirin in women's health?

Output: Migraine and cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of aspirin in women's health?. ### Response: Migraine and cardiovascular disease.


Instruction: What is the name of the study that examined the relationship between migraine and haemorrhagic stroke in women?

Output: prospective cohort study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined the relationship between migraine and haemorrhagic stroke in women?. ### Response: prospective cohort study.


Instruction: What is a population based case-control study of Migraines during pregnancy?

Output: BMJ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a population based case-control study of Migraines during pregnancy?. ### Response: BMJ.


Instruction: What is the US population based case-control study of stroke and vascular diseases?

Output: Migraines during pregnancy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the US population based case-control study of stroke and vascular diseases?. ### Response: Migraines during pregnancy.


Instruction: What is a risk of preeclampsia in relation to maternal history of migraine headaches?

Output: increased risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk of preeclampsia in relation to maternal history of migraine headaches?. ### Response: increased risk.


Instruction: When was the J Matern Fetal Neonatal Med published?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Matern Fetal Neonatal Med published?. ### Response: 2005.


Instruction: What is a risk factor for hyperten-sive disorders in pregnancy: a prospective cohort study?

Output: Migraine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for hyperten-sive disorders in pregnancy: a prospective cohort study?. ### Response: Migraine.


Instruction: What is the risk of preeclampsia in Peruvian women associated with headaches and migraines?

Output: increased

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of preeclampsia in Peruvian women associated with headaches and migraines?. ### Response: increased.


Instruction: What was the name of the subcommittee of the American Academy of Neurology?

Output: Quality Standards Subcommittee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the subcommittee of the American Academy of Neurology?. ### Response: Quality Standards Subcommittee.


Instruction: What is the name of the subcommittee of the American Academy of Neurology?

Output: Quality Standards Subcommittee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the subcommittee of the American Academy of Neurology?. ### Response: Quality Standards Subcommittee.


Instruction: When was the published correction published?

Output: 2000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the published correction published?. ### Response: 2000.


Instruction: What year did the quality standards sub committee of the american academy of neurology publish a correction?

Output: 2000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did the quality standards sub committee of the american academy of neurology publish a correction?. ### Response: 2000.


Instruction: What is the cost of the US obesity epidemic?

Output: Estimating the progression and cost

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cost of the US obesity epidemic?. ### Response: Estimating the progression and cost.


Instruction: When was the obesity epidemic in the United States?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the obesity epidemic in the United States?. ### Response: 2008.


Instruction: What was the weight of adults in the U.S. from 1999 to 2008?

Output: 294

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the weight of adults in the U.S. from 1999 to 2008?. ### Response: 294.


Instruction: What is the name of the journal that studies the prevalence of obesity among US adults from 1999 to 2008?

Output: JAMA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies the prevalence of obesity among US adults from 1999 to 2008?. ### Response: JAMA.


Instruction: When was the JAMA published?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the JAMA published?. ### Response: 2010.


Instruction: What is Vague J's French translation of La differenciation sexuelle?

Output: feateur determinant des formes de l’obesite

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Vague J's French translation of La differenciation sexuelle?. ### Response: feateur determinant des formes de l’obesite.


Instruction: What is the weight of the obesity epidemic among middle-aged women in the US?

Output: stroke rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the weight of the obesity epidemic among middle-aged women in the US?. ### Response: stroke rates.


Instruction: What are the body mass index and risk of stroke among Chinese men and women?

Output: 298

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the body mass index and risk of stroke among Chinese men and women?. ### Response: 298.


Instruction: What is the risk of stroke among Chinese men and women?

Output: Body mass index

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of stroke among Chinese men and women?. ### Response: Body mass index.


Instruction: What is Saito I, Iso H, Kokubo Y, Inoue M, Tsugane S?

Output: Body mass index

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Saito I, Iso H, Kokubo Y, Inoue M, Tsugane S?. ### Response: Body mass index.


Instruction: What is the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al.


Instruction: When is the 2021 Circulation. 143:e72–e227?

Output: February 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is the 2021 Circulation. 143:e72–e227?. ### Response: February 2.


Instruction: What is an example of Infective Endocarditis?

Output: valvular heart dis-ease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of Infective Endocarditis?. ### Response: valvular heart dis-ease.


Instruction: e15512.1 Classification of Endocarditis?

Output: Infective Endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: e15512.1 Classification of Endocarditis?. ### Response: Infective Endocarditis.


Instruction: Diagnosis of what?

Output: IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Diagnosis of what?. ### Response: IE.


Instruction: e15612.3 Medical Therapy?

Output: . . . . . . . . . . . . . . . . . . . . . . . . e16012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: e15612.3 Medical Therapy?. ### Response: . . . . . . . . . . . . . . . . . . . . . . . . e16012.


Instruction: . e16012.4.

Output: Intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: . e16012.4.. ### Response: Intervention.


Instruction: e16213. Pregnancy and VHD?

Output: Intervention  . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: e16213. Pregnancy and VHD?. ### Response: Intervention  . . . . . . . . . . . . . . . . . . . . . . . . . . . ..


Instruction: What is the name of the document that describes the initial management of women with VHD before and during pregnancy?

Output: e16513

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the document that describes the initial management of women with VHD before and during pregnancy?. ### Response: e16513.


Instruction: e16513.1.1. Medical Therapy for Women With VHD Before and During Pregnancy. e16613.1.2. What is the name of the intervention for women with Native VHD before and during pregnancy?

Output: Intervention for Women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: e16513.1.1. Medical Therapy for Women With VHD Before and During Pregnancy. e16613.1.2. What is the name of the intervention for women with Native VHD before and during pregnancy?. ### Response: Intervention for Women.


Instruction: What type of Valves are used in pregnant women?

Output: Prosthetic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of Valves are used in pregnant women?. ### Response: Prosthetic.


Instruction: What does e16613.2 cover?

Output: Prosthetic Valves in Pregnant Women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does e16613.2 cover?. ### Response: Prosthetic Valves in Pregnant Women.


Instruction: What is e16913.2.1 about?

Output: Prosthetic Valves in Pregnant Women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is e16913.2.1 about?. ### Response: Prosthetic Valves in Pregnant Women.


Instruction: How is anticoagulation done for pregnant women?

Output: Mechanical Prosthetic Heart  Valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is anticoagulation done for pregnant women?. ### Response: Mechanical Prosthetic Heart  Valves.


Instruction: What is the name of the woman who has a mechanical prosthetic heart valve?

Output: Pregnant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the woman who has a mechanical prosthetic heart valve?. ### Response: Pregnant.


Instruction: What type of heart valve does a woman have?

Output: Mechanical Prosthetic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of heart valve does a woman have?. ### Response: Mechanical Prosthetic.


Instruction: e17414.1. Evaluation and Management of CAD in Patients With VHD?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: e17414.1. Evaluation and Management of CAD in Patients With VHD?. ### Response: . . . . . . . . . . . . . . . . . . . . . ..


Instruction: e17414.1.1. Management of CAD in Patients Undergoing what?

Output: TAVI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: e17414.1.1. Management of CAD in Patients Undergoing what?. ### Response: TAVI.


Instruction: e17414.1.2. Management of CAD in Patients Undergoing Valve Surgery?

Output: e17414.1.1. Management of CAD in Patients Undergoing TAVI  . . . . . . . . . . . . . . . .

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: e17414.1.2. Management of CAD in Patients Undergoing Valve Surgery?. ### Response: e17414.1.1. Management of CAD in Patients Undergoing TAVI  . . . . . . . . . . . . . . . ..


Instruction: Intervention for AF in Patients With VHD?

Output: e17614.2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Intervention for AF in Patients With VHD?. ### Response: e17614.2.


Instruction: e17815.1. Diagnosis of Patients With VHD Undergoing Noncardiac Surgery?

Output: e17715. Noncardiac Surgery in Patients With VHD  . . . . . . . .

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: e17815.1. Diagnosis of Patients With VHD Undergoing Noncardiac Surgery?. ### Response: e17715. Noncardiac Surgery in Patients With VHD  . . . . . . . ..


Instruction: Management of the Symptomatic Patient. e17915.3.

Output: e17815.2. Management of the Symptomatic Patient  . . .e17915.3. Management of the Asymptomatic Patient  . .e18016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Management of the Symptomatic Patient. e17915.3.. ### Response: e17815.2. Management of the Symptomatic Patient  . . .e17915.3. Management of the Asymptomatic Patient  . .e18016.


Instruction: What is the name of the medication for the symptomatic patient?

Output: Mechanical Prosthetic Heart

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the medication for the symptomatic patient?. ### Response: Mechanical Prosthetic Heart.


Instruction: What is e18116.1?

Output: Prevention of Valve Disease: Stage A

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is e18116.1?. ### Response: Prevention of Valve Disease: Stage A.


Instruction: How is Valve Disease treated?

Output: Medical Therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is Valve Disease treated?. ### Response: Medical Therapy.


Instruction: Optimal Timing of Intervention: Stage C

Output: e18216

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Optimal Timing of Intervention: Stage C. ### Response: e18216.


Instruction: e18216.3. Optimal Timing of Intervention: Stage C.

Output: . . . . . . . . . . . . . . . . . . . . . e17815.2. Management of the Symptomatic Patient  . . .e17915.3. Management of the Asymptomatic Patient  . .e18016. Evidence Gaps and Future Directions  . . . . . . . . . . . . e18116.1. Prevention of Valve Disease: Stage A  . . . . . . . e18116.2. Medical Therapy to Treat or Prevent Disease Progression: Stage B  . . . . . . . . . . . . . . . . . . . . .

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: e18216.3. Optimal Timing of Intervention: Stage C.. ### Response: . . . . . . . . . . . . . . . . . . . . . e17815.2. Management of the Symptomatic Patient  . . .e17915.3. Management of the Asymptomatic Patient  . .e18016. Evidence Gaps and Future Directions  . . . . . . . . . . . . e18116.1. Prevention of Valve Disease: Stage A  . . . . . . . e18116.2. Medical Therapy to Treat or Prevent Disease Progression: Stage B  . . . . . . . . . . . . . . . . . . . . ..


Instruction: e184Appendix 1. Author Relationships With Industry and Other Entities (Relevant)

Output: 143:e72–e227

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: e184Appendix 1. Author Relationships With Industry and Other Entities (Relevant). ### Response: 143:e72–e227.


Instruction: e222Appendix 2. Reviewer Relationships With Industry and Other Entities (Comprehensive)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: e222Appendix 2. Reviewer Relationships With Industry and Other Entities (Comprehensive). ### Response: . . . . . . . . . . . ..


Instruction: What should be classified in patients with valvular heart dis-ease?

Output: Disease stages

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be classified in patients with valvular heart dis-ease?. ### Response: Disease stages.


Instruction: What are the stages A, B, C, and D?

Output: Disease stages in patients with valvular heart dis-ease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the stages A, B, C, and D?. ### Response: Disease stages in patients with valvular heart dis-ease.


Instruction: What are the symptoms of valvular heart failure?

Output: valve anatomy, the severity of valve dysfunction, and the response of the ventricle and pulmonary circulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the symptoms of valvular heart failure?. ### Response: valve anatomy, the severity of valve dysfunction, and the response of the ventricle and pulmonary circulation.


Instruction: What is the response of the ventricle and pulmonary circulation?

Output: Disease stages

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the response of the ventricle and pulmonary circulation?. ### Response: Disease stages.


Instruction: What is ARMYDA-6 MI?

Output: Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty-Myocardial In-farction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ARMYDA-6 MI?. ### Response: Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty-Myocardial In-farction.


Instruction: What are the loading doses of clopidogrel?

Output: 600- and 300-mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the loading doses of clopidogrel?. ### Response: 600- and 300-mg.


Instruction: What is the name of the randomized study?

Output: ARMYDA-6 MI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized study?. ### Response: ARMYDA-6 MI.


Instruction: What is a stan-dard-dose clopidogrel and high-dose aspirin in acute coronary syndrome?

Output: Double-dose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a stan-dard-dose clopidogrel and high-dose aspirin in acute coronary syndrome?. ### Response: Double-dose.


Instruction: What is the name of the randomised factorial trial?

Output: ARMYDA-6 MI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised factorial trial?. ### Response: ARMYDA-6 MI.


Instruction: When was the Lancet 376:1233–43.260?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Lancet 376:1233–43.260?. ### Response: 2010.


Instruction: What is prasugrel versus clopidogrel used for in patients with acute coronary syndromes?

Output: reperfusion with primary percutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is prasugrel versus clopidogrel used for in patients with acute coronary syndromes?. ### Response: reperfusion with primary percutaneous coronary intervention.


Instruction: What is the difference between clopidogrel and ticagrelor in ST-elevation acute coronary syndromes?

Output: Double-dose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between clopidogrel and ticagrelor in ST-elevation acute coronary syndromes?. ### Response: Double-dose.


Instruction: What is a platelet inhibition and patient outcomes trial?

Output: PLATO)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a platelet inhibition and patient outcomes trial?. ### Response: PLATO).


Instruction: What is TRITON-TIMI 38?

Output: elevation myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is TRITON-TIMI 38?. ### Response: elevation myocardial infarction.


Instruction: What is the name of the double-blind, randomised controlled trial?

Output: ARMYDA-6 MI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the double-blind, randomised controlled trial?. ### Response: ARMYDA-6 MI.


Instruction: How many patients were enrolled in 31 randomized controlled trials?

Output: 192,036

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were enrolled in 31 randomized controlled trials?. ### Response: 192,036.


Instruction: What is the association of aspirin and clopidogrel with thrombosis and bleeding?

Output: Aspirin to prevent cardio-vascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association of aspirin and clopidogrel with thrombosis and bleeding?. ### Response: Aspirin to prevent cardio-vascular disease.


Instruction: What is the name of the randomized, placebo-controlled trial of platelet glycoprotein IIb/IIIa blockade with primary angioplasty for acute myocardial infarction?

Output: ARMYDA-6 MI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized, placebo-controlled trial of platelet glycoprotein IIb/IIIa blockade with primary angioplasty for acute myocardial infarction?. ### Response: ARMYDA-6 MI.


Instruction: What is angioplasty with or without abciximab used for?

Output: stenting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is angioplasty with or without abciximab used for?. ### Response: stenting.


Instruction: What is the N Engl J Med 2002 346:957-66.267?

Output: Comparison of angioplasty with stenting, with or without abciximab, in acute myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the N Engl J Med 2002 346:957-66.267?. ### Response: Comparison of angioplasty with stenting, with or without abciximab, in acute myocardial infarction.


Instruction: What is stenting for for acute myocardial infarction?

Output: Platelet glycoprotein IIb/IIIa inhibition with coronary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is stenting for for acute myocardial infarction?. ### Response: Platelet glycoprotein IIb/IIIa inhibition with coronary.


Instruction: When did N Engl J Med issue 344:1895–903.268?

Output: 2001

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did N Engl J Med issue 344:1895–903.268?. ### Response: 2001.


Instruction: What is tirofiban used for in patients with ST-segment el-evation?

Output: short- and long-term clinical outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is tirofiban used for in patients with ST-segment el-evation?. ### Response: short- and long-term clinical outcome.


Instruction: In what year did J Am Coll Cardiol issue 55:2446–55?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did J Am Coll Cardiol issue 55:2446–55?. ### Response: 2010.


Instruction: What is the difference between cestac and enoxaparin in obese patients and patients with severe renal impairment?

Output: pharmacodynamics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between cestac and enoxaparin in obese patients and patients with severe renal impairment?. ### Response: pharmacodynamics.


Instruction: What are the results of the ESSENCE and TIMI 11B studies?

Output: enoxaparin in patients who are obese and patients with severe renal impairment: analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of the ESSENCE and TIMI 11B studies?. ### Response: enoxaparin in patients who are obese and patients with severe renal impairment: analysis.


Instruction: What did Cestac P, Bagheri H, Lapeyre-Mestre M, et al. find out about the use and safety of low molecular weight heparins in medical inpatients?

Output: Utilisation and safety

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Cestac P, Bagheri H, Lapeyre-Mestre M, et al. find out about the use and safety of low molecular weight heparins in medical inpatients?. ### Response: Utilisation and safety.


Instruction: What is the name of the study conducted in medical inpatients?

Output: Drug Saf

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study conducted in medical inpatients?. ### Response: Drug Saf.


Instruction: How many patients were studied in 2003?

Output: 197 - 207

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were studied in 2003?. ### Response: 197 - 207.


Instruction: What is enoxaparin and bleeding complications?

Output: a review in patients with and without renal insufﬁ  ciency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is enoxaparin and bleeding complications?. ### Response: a review in patients with and without renal insufﬁ  ciency.


Instruction: What was a review in patients with and without renal insuffi ciency?

Output: Enoxaparin and bleeding complications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a review in patients with and without renal insuffi ciency?. ### Response: Enoxaparin and bleeding complications.


Instruction: How many ( 7 ) were there in 2000?

Output: 20

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many ( 7 ) were there in 2000?. ### Response: 20.


Instruction: What is the pharmacokinetics of a drug?

Output: comparative

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the pharmacokinetics of a drug?. ### Response: comparative.


Instruction: What is Jariwala's name?

Output: N

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Jariwala's name?. ### Response: N.


Instruction: What is enoxaparin used for in obese volunteers?

Output: pharma-cokinetics and pharmacodynamics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is enoxaparin used for in obese volunteers?. ### Response: pharma-cokinetics and pharmacodynamics.


Instruction: How many ( 3 ): 308-318 in 2002?

Output: 72

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many ( 3 ): 308-318 in 2002?. ### Response: 72.


Instruction: Rabbat CG, Cook CG, What is the name of the drug used in obese patients?

Output: enoxaparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Rabbat CG, Cook CG, What is the name of the drug used in obese patients?. ### Response: enoxaparin.


Instruction: What is Dalteparin thromboprophylaxis for critically ill medical-surgical patients with renal insufficiency?

Output: low-molecular-weight heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Dalteparin thromboprophylaxis for critically ill medical-surgical patients with renal insufficiency?. ### Response: low-molecular-weight heparin.


Instruction: What is the name of the group that studies critical care?

Output: Canadian Critical Care Trials Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that studies critical care?. ### Response: Canadian Critical Care Trials Group.


Instruction: How many cases were there in 2005?

Output: 357 - 363

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many cases were there in 2005?. ### Response: 357 - 363.


Instruction: What was the number of cases?

Output: 167

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the number of cases?. ### Response: 167.


Instruction: What is dalteparin used for in critically ill patients?

Output: Prophylaxis against deep vein thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is dalteparin used for in critically ill patients?. ### Response: Prophylaxis against deep vein thrombosis.


Instruction: What is the DIRECT study?

Output: Prophylaxis against deep vein thrombosis in critically ill patients with severe renal insufﬁ  ciency with the low-molecular-weight heparin dalteparin: an assessment of safety and pharmacodynamics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the DIRECT study?. ### Response: Prophylaxis against deep vein thrombosis in critically ill patients with severe renal insufﬁ  ciency with the low-molecular-weight heparin dalteparin: an assessment of safety and pharmacodynamics.


Instruction: How many years was Tinzaparin used?

Output: eight

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many years was Tinzaparin used?. ### Response: eight.


Instruction: What year did Tinzaperin first appear in the literature?

Output: 1987

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Tinzaperin first appear in the literature?. ### Response: 1987.


Instruction: Tinzaparin and enox-aparin given at prophylactic dose for eight days in medical elderly patients with impaired renal function: a comparative pharmacokinetic study?

Output: M ,  Drouet   L ,  et al .

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Tinzaparin and enox-aparin given at prophylactic dose for eight days in medical elderly patients with impaired renal function: a comparative pharmacokinetic study?. ### Response: M ,  Drouet   L ,  et al ..


Instruction: How many pages were there in the 97 ( 4 ): 581 - 586?

Output: 168

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many pages were there in the 97 ( 4 ): 581 - 586?. ### Response: 168.


Instruction: What is the molecular weight of heparin?

Output: low

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the molecular weight of heparin?. ### Response: low.


Instruction: What are the effects on eicosanoids, clotting and complement factors?

Output: Protamine reversal of anticoagulation achieved with a low molecular weight heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the effects on eicosanoids, clotting and complement factors?. ### Response: Protamine reversal of anticoagulation achieved with a low molecular weight heparin.


Instruction: What is PK 10169?

Output: Partial rever-sal of low molecular weight heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PK 10169?. ### Response: Partial rever-sal of low molecular weight heparin.


Instruction: What is the name of the drug that has a low molecular weight?

Output: heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug that has a low molecular weight?. ### Response: heparin.


Instruction: What is the effect of protamine sulfate on Xa activation?

Output: Partial rever-sal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of protamine sulfate on Xa activation?. ### Response: Partial rever-sal.


Instruction: How many. 170. Racanelli A, Fareed J, Walenga JM, Coyne E. Biochemical and pharmacologic studies on the protamine interactions. 2012 American College of Chest.

Output: 170

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many. 170. Racanelli A, Fareed J, Walenga JM, Coyne E. Biochemical and pharmacologic studies on the protamine interactions. 2012 American College of Chest.. ### Response: 170.


Instruction: What year was the American College of Chest Physicians founded?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the American College of Chest Physicians founded?. ### Response: 2012.


Instruction: Who wrote the book The Protamine Interactions?

Output: Kimberly Henricks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote the book The Protamine Interactions?. ### Response: Kimberly Henricks.


Instruction: On what date was the book released?

Output: February 10, 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On what date was the book released?. ### Response: February 10, 2012.


Instruction: What is reason-able when the aortic diameter is >4.5 cm?

Output: replacement of the ascending aorta

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reason-able when the aortic diameter is >4.5 cm?. ### Response: replacement of the ascending aorta.


Instruction: There are a limited number of patients with BAV who meet criteria for operative intervention on what?

Output: the aortic sinuses and/or ascending aorta

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There are a limited number of patients with BAV who meet criteria for operative intervention on what?. ### Response: the aortic sinuses and/or ascending aorta.


Instruction: What should be performed at a Comprehensive Valve Center?

Output: surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be performed at a Comprehensive Valve Center?. ### Response: surgery.


Instruction: What is the growing experience with valve-sparing surgery?

Output: highly selected patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the growing experience with valve-sparing surgery?. ### Response: highly selected patients.


Instruction: What is the risk of dissection high enough to warrant operative intervention in patients who do not fulfill criteria for AVR on the basis of severe AS or AR?

Output: aortic dilation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of dissection high enough to warrant operative intervention in patients who do not fulfill criteria for AVR on the basis of severe AS or AR?. ### Response: aortic dilation.


Instruction: What is the basis of severe AS or AR?

Output: aortic dilation at which the risk of dissection is high enough to warrant operative intervention in patients who do not fulfill criteria for AVR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the basis of severe AS or AR?. ### Response: aortic dilation at which the risk of dissection is high enough to warrant operative intervention in patients who do not fulfill criteria for AVR.


Instruction: What are asymptomatic patients with a BAV and a diameter of the aortic sinuses and/or ascending Aorta of 5.0 to 5.5 cm at low surgical risk?

Output: no additional risk factors for aortic dissection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are asymptomatic patients with a BAV and a diameter of the aortic sinuses and/or ascending Aorta of 5.0 to 5.5 cm at low surgical risk?. ### Response: no additional risk factors for aortic dissection.


Instruction: Where is surgery to replace the aortic sinuses performed?

Output: Comprehensive Valve Center

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is surgery to replace the aortic sinuses performed?. ### Response: Comprehensive Valve Center.


Instruction: What is needed to clearly outline the risks of surgery and weigh them against the potential risks?

Output: shared decision-making

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed to clearly outline the risks of surgery and weigh them against the potential risks?. ### Response: shared decision-making.


Instruction: What are the risks of surgery and weigh them against the potential reduction in future risk of aortic dissection?

Output: shared decision-making between the patient and the healthcare team is needed to clearly outline the risks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the risks of surgery and weigh them against the potential reduction in future risk of aortic dissection?. ### Response: shared decision-making between the patient and the healthcare team is needed to clearly outline the risks.


Instruction: How are the studies that support the recommendations summarized in Online Data Supplement 18?

Output: Referenced

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are the studies that support the recommendations summarized in Online Data Supplement 18?. ### Response: Referenced.


Instruction: Where is aortic valve repair considered in patients with BAV and severe AR who meet criteria for AVR?

Output: Comprehensive Valve Center

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is aortic valve repair considered in patients with BAV and severe AR who meet criteria for AVR?. ### Response: Comprehensive Valve Center.


Instruction: Where is the surgery performed in selected patients if the surgery is performed?

Output: Comprehensive Valve Center

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the surgery performed in selected patients if the surgery is performed?. ### Response: Comprehensive Valve Center.


Instruction: Where is the surgery performed?

Output: Comprehensive Valve Center

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the surgery performed?. ### Response: Comprehensive Valve Center.


Instruction: What is the indications for timing of aortic valve interven-tion?

Output: similar to those for trileaflet aortic valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the indications for timing of aortic valve interven-tion?. ### Response: similar to those for trileaflet aortic valves.


Instruction: What are the indications for timing of aortic valve interven-tion similar to?

Output: trileaflet aortic valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the indications for timing of aortic valve interven-tion similar to?. ### Response: trileaflet aortic valves.