Instruction: What drugs did the Pediatric Electrophysiology Group treat?

Output: encainide and flecainide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drugs did the Pediatric Electrophysiology Group treat?. ### Response: encainide and flecainide.


Instruction: When did the J Am Coll Cardiol. 1991 issue 18:356–65?

Output: 1991

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the J Am Coll Cardiol. 1991 issue 18:356–65?. ### Response: 1991.


Instruction: What drug induced thyrotoxicosis in adults with congenital heart disease-clinical pre-sentation and response to therapy?

Output: Amiodarone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug induced thyrotoxicosis in adults with congenital heart disease-clinical pre-sentation and response to therapy?. ### Response: Amiodarone.


Instruction: What is the risk factor for amiodarone-associated thy-roid dysfunction in adults with congenital heart disease?

Output: inducible ventricular arrhythmia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk factor for amiodarone-associated thy-roid dysfunction in adults with congenital heart disease?. ### Response: inducible ventricular arrhythmia.


Instruction: When did Circulation. 1999;100:149–54?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circulation. 1999;100:149–54?. ### Response: 1999.


Instruction: What was induction of ventricular tachycardia during electrophysiologic study after repair of tetralogy of Fallot?

Output: impact on survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was induction of ventricular tachycardia during electrophysiologic study after repair of tetralogy of Fallot?. ### Response: impact on survival.


Instruction: What is the name of the repair of tetralogy of Fallot?

Output: Pulmonary valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the repair of tetralogy of Fallot?. ### Response: Pulmonary valve replacement.


Instruction: When was the J Am Coll Cardiol 1:1493–502?

Output: 1983

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol 1:1493–502?. ### Response: 1983.


Instruction: What was the rate of inducible ventricular arrhythmia?

Output: S10.8-36

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the rate of inducible ventricular arrhythmia?. ### Response: S10.8-36.


Instruction: What is the rate of inducible ventricular arrhythmia in adults with congenital heart disease?

Output: S10.8-36

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the rate of inducible ventricular arrhythmia in adults with congenital heart disease?. ### Response: S10.8-36.


Instruction: What was the Am J Cardiol. 2010;106:730–6. S10.8-36.

Output: congenital heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the Am J Cardiol. 2010;106:730–6. S10.8-36.. ### Response: congenital heart disease.


Instruction: What are the contemporary predictors of death and sustained ventricular tachycardia in patients with repaired tetralogy of Fallot enrolled in?

Output: INDICATOR cohort

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the contemporary predictors of death and sustained ventricular tachycardia in patients with repaired tetralogy of Fallot enrolled in?. ### Response: INDICATOR cohort.


Instruction: How long did Fontan circulation last?

Output: over 30 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did Fontan circulation last?. ### Response: over 30 years.


Instruction: What did Sakamoto T, Nagashima M, Hiramatsu T, et al. learn from Fontan patients?

Output: circulation over 30 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Sakamoto T, Nagashima M, Hiramatsu T, et al. learn from Fontan patients?. ### Response: circulation over 30 years.


Instruction: When did Asian Cardiovasc Thorac Ann. 2016 24:765–71.

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Asian Cardiovasc Thorac Ann. 2016 24:765–71.. ### Response: 2016.


Instruction: What is the impact of Pulmonary valve replacement in tetralogy of Fallot?

Output: impact on survival and ventricular tachycardia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact of Pulmonary valve replacement in tetralogy of Fallot?. ### Response: impact on survival and ventricular tachycardia.


Instruction: What was the impact on survival and ventricular tachycardia?

Output: Pulmonary valve replacement in tetralogy of Fallot

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the impact on survival and ventricular tachycardia?. ### Response: Pulmonary valve replacement in tetralogy of Fallot.


Instruction: When was the Circulation.119:445-51?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circulation.119:445-51?. ### Response: 2009.


Instruction: How many centers did a retrospective implantable cardioverter-defibrillator registry have?

Output: multicenter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many centers did a retrospective implantable cardioverter-defibrillator registry have?. ### Response: multicenter.


Instruction: What is pedi-atric and congenital heart disease patients treated for?

Output: thyrotoxicosis in adults with congenital heart disease-clinical pre-sentation and response to therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is pedi-atric and congenital heart disease patients treated for?. ### Response: thyrotoxicosis in adults with congenital heart disease-clinical pre-sentation and response to therapy.


Instruction: What is the J Am Coll Cardiol. 2008:51:1685-91?

Output: multicenter retrospective implantable cardioverter-defibrillator registry of pedi-atric and congenital heart disease patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the J Am Coll Cardiol. 2008:51:1685-91?. ### Response: multicenter retrospective implantable cardioverter-defibrillator registry of pedi-atric and congenital heart disease patients.


Instruction: Who is Khanna AD, Warnes CA, Phillips SD, et al?

Output: Single-center experience with implantable cardioverter-defibrillators in adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Khanna AD, Warnes CA, Phillips SD, et al?. ### Response: Single-center experience with implantable cardioverter-defibrillators in adults.


Instruction: What increases eligibility for subcutaneous implantable cardio-verter defibrillator therapy in adults with congenital heart disease?

Output: Right parasternal lead placement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What increases eligibility for subcutaneous implantable cardio-verter defibrillator therapy in adults with congenital heart disease?. ### Response: Right parasternal lead placement.


Instruction: What does right parasternal lead placement increase eligibility for?

Output: subcutaneous implantable cardio-verter defibrillator therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does right parasternal lead placement increase eligibility for?. ### Response: subcutaneous implantable cardio-verter defibrillator therapy.


Instruction: What is implantable cardio-verter defibrillator therapy in adults with congenital heart disease?

Output: subcutaneous

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is implantable cardio-verter defibrillator therapy in adults with congenital heart disease?. ### Response: subcutaneous.


Instruction: What is the journal Circ J. 2016?

Output: 80:1328–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the journal Circ J. 2016?. ### Response: 80:1328–.


Instruction: What is the Japanese society of hypertension known as?

Output: JSH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Japanese society of hypertension known as?. ### Response: JSH.


Instruction: What does JSH stand for?

Output: Japanese society of hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does JSH stand for?. ### Response: Japanese society of hypertension.


Instruction: What is JSH?

Output: Japanese society of hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is JSH?. ### Response: Japanese society of hypertension.


Instruction: What are JSH guidelines for self-monitoring of blood pressure at home?

Output: Japanese society of hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are JSH guidelines for self-monitoring of blood pressure at home?. ### Response: Japanese society of hypertension.


Instruction: Ernst ME, Bergus GR. Ambulatory blood pressure monitoring.

Output: South MedJ2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Ernst ME, Bergus GR. Ambulatory blood pressure monitoring.. ### Response: South MedJ2003.


Instruction: What is the name of the drug used to treat hypertensivepatients with peripheral and coronary artery disease?

Output: VErapamil-SR/Trandolapril STudy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used to treat hypertensivepatients with peripheral and coronary artery disease?. ### Response: VErapamil-SR/Trandolapril STudy.


Instruction: What are the names of the drugs used in this study?

Output: benazepril andlosartan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the drugs used in this study?. ### Response: benazepril andlosartan.


Instruction: What is the name of the drug used to treat coronary artery disease?

Output: VErapamil-SR/Trandolapril STudy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used to treat coronary artery disease?. ### Response: VErapamil-SR/Trandolapril STudy.


Instruction: How many people were enrolled in the Hypertension 2010 study?

Output: 48– 53.412

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were enrolled in the Hypertension 2010 study?. ### Response: 48– 53.412.


Instruction: What drug was used in the Ongoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial?

Output: Prognostic value of blood pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug was used in the Ongoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial?. ### Response: Prognostic value of blood pressure.


Instruction: What is a target for albuminuria?

Output: renoprotective therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a target for albuminuria?. ### Response: renoprotective therapy.


Instruction: What is an association of lowblood pressure with increased mortality in patients with moderate to severe chronic kidney disease?

Output: Kovesdy CP, Trivedi BK, Kalantar-Zadeh K et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an association of lowblood pressure with increased mortality in patients with moderate to severe chronic kidney disease?. ### Response: Kovesdy CP, Trivedi BK, Kalantar-Zadeh K et al.


Instruction: What is a target for renoprotective therapy independent of blood pressure in patients with type 2 diabetic nephropathy?

Output: Albuminuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a target for renoprotective therapy independent of blood pressure in patients with type 2 diabetic nephropathy?. ### Response: Albuminuria.


Instruction: What was post hoc analysis from the Reductionof Endpoints in NIDDM with the Angiotensin II Antagonist Losartan(RENAAL) trial?

Output: Albuminuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was post hoc analysis from the Reductionof Endpoints in NIDDM with the Angiotensin II Antagonist Losartan(RENAAL) trial?. ### Response: Albuminuria.


Instruction: What is associated with long-term renal outcome in type 2 diabetic patients with microalbumin-uria?

Output: Initial angiotensinreceptor blockade-induced decrease in albuminuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with long-term renal outcome in type 2 diabetic patients with microalbumin-uria?. ### Response: Initial angiotensinreceptor blockade-induced decrease in albuminuria.


Instruction: What is a post hoc analysis of the IRMA-2 trial?

Output: Initial angiotensinreceptor blockade-induced decrease in albuminuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a post hoc analysis of the IRMA-2 trial?. ### Response: Initial angiotensinreceptor blockade-induced decrease in albuminuria.


Instruction: What is the name of the randomized controlled study of benazepril andlosartan in chronic renal insufficiency?

Output: Renoprotection of Optimal AntiproteinuricDoses (ROAD) Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized controlled study of benazepril andlosartan in chronic renal insufficiency?. ### Response: Renoprotection of Optimal AntiproteinuricDoses (ROAD) Study.


Instruction: When was the J Am Soc Nephrol 2007 published?

Output: 18:1889– 1898.417

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Soc Nephrol 2007 published?. ### Response: 18:1889– 1898.417.


Instruction: What does a low-sodium diet potentiate in type 2 diabetes?

Output: losartan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does a low-sodium diet potentiate in type 2 diabetes?. ### Response: losartan.


Instruction: What is the effect of ACE inhibition by lisinopril?

Output: antiproteinuric effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of ACE inhibition by lisinopril?. ### Response: antiproteinuric effect.


Instruction: What is type 2 diabetes?

Output: nephropathy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is type 2 diabetes?. ### Response: nephropathy.


Instruction: What can hydrochlorothiazide restore?

Output: The blunting of theantiproteinuric efﬁcacy of ACE inhibition by high sodium intake

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can hydrochlorothiazide restore?. ### Response: The blunting of theantiproteinuric efﬁcacy of ACE inhibition by high sodium intake.


Instruction: How does high sodium intake blunt the effect of ACE inhibition?

Output: hydrochlorothiazide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does high sodium intake blunt the effect of ACE inhibition?. ### Response: hydrochlorothiazide.


Instruction: What is the maximum dose ofcandesartan in proteinuric renal disease?

Output: Supramaximal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the maximum dose ofcandesartan in proteinuric renal disease?. ### Response: Supramaximal.


Instruction: How long does it take for a patient to undergo cardiac catheterization?

Output: 24 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take for a patient to undergo cardiac catheterization?. ### Response: 24 hours.


Instruction: What type of failure does fibrinolytic failure cause?

Output: Severe heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of failure does fibrinolytic failure cause?. ### Response: Severe heart failure.


Instruction: How long is it necessary to perform catheterization within 24 hours to decrease reinfarction and recur-rent ischemic events?

Output: performed within 24 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is it necessary to perform catheterization within 24 hours to decrease reinfarction and recur-rent ischemic events?. ### Response: performed within 24 hours.


Instruction: How long after symptom onset do PCI*STEMI symptoms last?

Output: 12 h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after symptom onset do PCI*STEMI symptoms last?. ### Response: 12 h.


Instruction: What type of patients present between 12 and 24 h after symptoms onset?

Output: Asymptomatic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of patients present between 12 and 24 h after symptoms onset?. ### Response: Asymptomatic.


Instruction: Asymptomatic patients presenting between 12 and 24 h after symptom onset and higher risk IIb C N/ANoninfarct artery PCI at the time of primary PCI in patients without what?

Output: hemodynamiccompromise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Asymptomatic patients presenting between 12 and 24 h after symptom onset and higher risk IIb C N/ANoninfarct artery PCI at the time of primary PCI in patients without what?. ### Response: hemodynamiccompromise.


Instruction: What is evidence for for fibrinolytic failure or infarct artery reocclusion IIa B 385,386?

Output: STEMIClinical

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is evidence for for fibrinolytic failure or infarct artery reocclusion IIa B 385,386?. ### Response: STEMIClinical.


Instruction: What type of testing did Ischemia on?

Output: noninvasive

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of testing did Ischemia on?. ### Response: noninvasive.


Instruction: What is the goal of primary PCI within 90 min of first medical contact when a patient presents to a hospital with PCI capability?

Output: No Benefit B 418–420*

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the goal of primary PCI within 90 min of first medical contact when a patient presents to a hospital with PCI capability?. ### Response: No Benefit B 418–420*.


Instruction: How long after STEMI is a completely occluded infarct artery seen?

Output: H1102224 h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after STEMI is a completely occluded infarct artery seen?. ### Response: H1102224 h.


Instruction: How long does it take for a patient to present to a hospital with PCI capability?

Output: 120 min

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take for a patient to present to a hospital with PCI capability?. ### Response: 120 min.


Instruction: What indicates class of recommendation?

Output: COR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates class of recommendation?. ### Response: COR.


Instruction: What does PCI stand for?

Output: percutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does PCI stand for?. ### Response: percutaneous coronary intervention.


Instruction: What is STEMI?

Output: ST-elevat ionmyocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is STEMI?. ### Response: ST-elevat ionmyocardial infarction.


Instruction: When was the PCI guideline released?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the PCI guideline released?. ### Response: 2011.


Instruction: How many large studies in high-cardiovascular-risk patients showed cardiovascular protec-tive effects by ACE inhibitors?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many large studies in high-cardiovascular-risk patients showed cardiovascular protec-tive effects by ACE inhibitors?. ### Response: 2.


Instruction: How many studies in low-cardiovas-cular-risk people did not show cardiovascular pro-tective effects?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies in low-cardiovas-cular-risk people did not show cardiovascular pro-tective effects?. ### Response: 1.


Instruction: What trial randomized 25 620 patients?

Output: Ongoing Telmisartan Alone and In Combination with Ramipril Global Endpoint Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What trial randomized 25 620 patients?. ### Response: Ongoing Telmisartan Alone and In Combination with Ramipril Global Endpoint Trial.


Instruction: How many patients did the ONTARGET trial randomize?

Output: 25 620

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients did the ONTARGET trial randomize?. ### Response: 25 620.


Instruction: What percentage of the patients had a history of CAD?

Output: 74%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the patients had a history of CAD?. ### Response: 74%.


Instruction: How long did the median follow-up last?

Output: 4.7 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the median follow-up last?. ### Response: 4.7 years.


Instruction: How long was the median follow-up?

Output: 4.7 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the median follow-up?. ### Response: 4.7 years.


Instruction: What was the primary outcome of the 3 groups?

Output: cardiovascular death, nonfatal MI, non-fatal stroke, and hospitalization for HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary outcome of the 3 groups?. ### Response: cardiovascular death, nonfatal MI, non-fatal stroke, and hospitalization for HF.


Instruction: Which group had an increased risk of hypotensive symptoms, syncope and renal dysfunction?

Output: combination treatment group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which group had an increased risk of hypotensive symptoms, syncope and renal dysfunction?. ### Response: combination treatment group.


Instruction: Hypotensive symptoms, syncope, and renal dysfunction compared with those in the ramipril group?

Output: combination treatment group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hypotensive symptoms, syncope, and renal dysfunction compared with those in the ramipril group?. ### Response: combination treatment group.


Instruction: What did the investigators conclude had similar benefits?

Output: ramipril and telmisartan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the investigators conclude had similar benefits?. ### Response: ramipril and telmisartan.


Instruction: The combination of ACE inhibitor and ARB in this high-cardiovascular-risk group was associated with what?

Output: more side effects and no increase in benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The combination of ACE inhibitor and ARB in this high-cardiovascular-risk group was associated with what?. ### Response: more side effects and no increase in benefit.


Instruction: ARBs have been shown to reduce the incidence or severity of what?

Output: IHD events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ARBs have been shown to reduce the incidence or severity of what?. ### Response: IHD events.


Instruction: Angiotensin Receptor Blockers can reduce the progression of renal disease in what type of diabetes mellitus?

Output: type 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Angiotensin Receptor Blockers can reduce the progression of renal disease in what type of diabetes mellitus?. ### Response: type 2.


Instruction: What is considered an alternative therapy in individuals with cardiovascular disease?

Output: ARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is considered an alternative therapy in individuals with cardiovascular disease?. ### Response: ARBs.


Instruction: What is considered to be an alternative therapy in individuals with cardiovascular disease who are intolerant of ACE inhibitors?

Output: ARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is considered to be an alternative therapy in individuals with cardiovascular disease who are intolerant of ACE inhibitors?. ### Response: ARBs.


Instruction: In the Valsartan Antihypertensive Long-term Use Evaluation study, protection against a composite of cardiovascular events was similar to that observed for what drug?

Output: CCB amlodipine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the Valsartan Antihypertensive Long-term Use Evaluation study, protection against a composite of cardiovascular events was similar to that observed for what drug?. ### Response: CCB amlodipine.


Instruction: What was similar to that observed for the CCB amlodipine?

Output: protection against a composite of cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was similar to that observed for the CCB amlodipine?. ### Response: protection against a composite of cardiovascular events.


Instruction: In the early stages of the V ALUE trial, what may have confounded outcomes for MI and especially stroke?

Output: differences in BP control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the early stages of the V ALUE trial, what may have confounded outcomes for MI and especially stroke?. ### Response: differences in BP control.


Instruction: What was not shown in the Optimal Trial in Myocardial Infarction With the Angiotensin II Antagonist Losartan?

Output: Beneficial cardiovascular outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not shown in the Optimal Trial in Myocardial Infarction With the Angiotensin II Antagonist Losartan?. ### Response: Beneficial cardiovascular outcomes.


Instruction: The lack of ben-efit may have been attributable to inadequate doses of what?

Output: losar -tan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The lack of ben-efit may have been attributable to inadequate doses of what?. ### Response: losar -tan.


Instruction: What was the ARB valsartan had in the VALIANT trial?

Output: effects similar to those of the ACE inhibitor captopril in reducing cardiovascular event end points

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the ARB valsartan had in the VALIANT trial?. ### Response: effects similar to those of the ACE inhibitor captopril in reducing cardiovascular event end points.


Instruction: What was the name of the Acute Myocardial Infarction Trial?

Output: V ALIANT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the Acute Myocardial Infarction Trial?. ### Response: V ALIANT.


Instruction: The ARB valsartan had effects similar to those of what other ACE inhibitor?

Output: captopril

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The ARB valsartan had effects similar to those of what other ACE inhibitor?. ### Response: captopril.


Instruction: What did the ARB and ACE inhib-itor yield?

Output: an increase in adverse events with no incremental benefit for cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the ARB and ACE inhib-itor yield?. ### Response: an increase in adverse events with no incremental benefit for cardiovascular events.


Instruction: How long did the telmisartan trial last?

Output: 4.7 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the telmisartan trial last?. ### Response: 4.7 years.


Instruction: What was the median duration of the trial?

Output: 4.7 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the median duration of the trial?. ### Response: 4.7 years.


Instruction: How many high-risk patients had CAD?

Output: 75%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many high-risk patients had CAD?. ### Response: 75%.


Instruction: How long was the duration of the study?

Output: 4.7 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the duration of the study?. ### Response: 4.7 years.


Instruction: What was the mean BP in the telmisartan group?

Output: 4.0/2.2 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean BP in the telmisartan group?. ### Response: 4.0/2.2 mm Hg.


Instruction: Which group had a BP of 4.0/2.2 mm Hg lower than those randomized to placebo?

Output: telmisartan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which group had a BP of 4.0/2.2 mm Hg lower than those randomized to placebo?. ### Response: telmisartan.


Instruction: What was the mean achievedBP in the nifedipine group?

Output: 147/85 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean achievedBP in the nifedipine group?. ### Response: 147/85 mm Hg.


Instruction: What was it in the placebo group that was 156/92 mm Hg?

Output: BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was it in the placebo group that was 156/92 mm Hg?. ### Response: BP.


Instruction: In the lower-BP nippedipine treated group, what were the exclusion criteria?

Output: Patients with SCr of Z1.5 mg/dl(133mmol/l)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the lower-BP nippedipine treated group, what were the exclusion criteria?. ### Response: Patients with SCr of Z1.5 mg/dl(133mmol/l).


Instruction: What type of arrythmia was found in the lower-BP nifedipine treated group?

Output: severe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of arrythmia was found in the lower-BP nifedipine treated group?. ### Response: severe.


Instruction: What was the exclusion criteria for secondary hypertension?

Output: a SCr level 41.7 mg/dl (4150mmol/l)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the exclusion criteria for secondary hypertension?. ### Response: a SCr level 41.7 mg/dl (4150mmol/l).


Instruction: How old were the patients in the Hypertension in the Very Elderly Trial (HYVET)?

Output: 80 years of age or older

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old were the patients in the Hypertension in the Very Elderly Trial (HYVET)?. ### Response: 80 years of age or older.


Instruction: How is a sustained BP of Z160 mm Hg beneficial for elderly patients?

Output: BP lowering treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is a sustained BP of Z160 mm Hg beneficial for elderly patients?. ### Response: BP lowering treatment.


Instruction: What was the target BP for the active-treatment group?

Output: systolic o150 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the target BP for the active-treatment group?. ### Response: systolic o150 mm Hg.


Instruction: How did the investigators achieve a BP with indapa-mide plus perindopril?

Output: if needed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did the investigators achieve a BP with indapa-mide plus perindopril?. ### Response: if needed.


Instruction: Indapa-mide plus perindopril was compared to 159/83 mm Hg with what?

Output: placebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Indapa-mide plus perindopril was compared to 159/83 mm Hg with what?. ### Response: placebo.


Instruction: In the low-BPactive-treatment group, what was shown to reduce the rates of all-cause mortality and stroke over a median of 1.8 years of follow-up?

Output: indapa-mide plus perindopril

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the low-BPactive-treatment group, what was shown to reduce the rates of all-cause mortality and stroke over a median of 1.8 years of follow-up?. ### Response: indapa-mide plus perindopril.


Instruction: Patients were withdrawn if systolic BP fell to what level?

Output: o110 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients were withdrawn if systolic BP fell to what level?. ### Response: o110 mm Hg.


Instruction: What was the SCr level for an 80-year-old white man?

Output: 41.7 mg/dl

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the SCr level for an 80-year-old white man?. ### Response: 41.7 mg/dl.


Instruction: What is the CKD-EPI?

Output: CKD Epidemiology Collaboration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the CKD-EPI?. ### Response: CKD Epidemiology Collaboration.


Instruction: What was the GFR for an 80-year-old white woman?

Output: 29 or28 ml/min/1.73 m2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the GFR for an 80-year-old white woman?. ### Response: 29 or28 ml/min/1.73 m2.


Instruction: What were the baseline creatinine levels in the active-treatment andplacebo groups?

Output: 88.6 mmol/l (1.0 mg/dl) and 89.2 mmol/L (1.0 mg/dl)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the baseline creatinine levels in the active-treatment andplacebo groups?. ### Response: 88.6 mmol/l (1.0 mg/dl) and 89.2 mmol/L (1.0 mg/dl).


Instruction: What did the active-treatment andplacebo groups have that were well below the exclusion level?

Output: mean baseline creatinine levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the active-treatment andplacebo groups have that were well below the exclusion level?. ### Response: mean baseline creatinine levels.


Instruction: What is not possible to extrapolate these datato?

Output: known advanced CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not possible to extrapolate these datato?. ### Response: known advanced CKD.


Instruction: What is the BP target level?

Output: 150/80 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the BP target level?. ### Response: 150/80 mm Hg.


Instruction: What does not specifically address CKDpatients with a GFR?

Output: this evidence provides some reassurance regard-ing treatment of high BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not specifically address CKDpatients with a GFR?. ### Response: this evidence provides some reassurance regard-ing treatment of high BP.


Instruction: How many Japanese studies failed to show any benefit or harm from reducing systolic BP to o140 mm Hg in otherwisehealthy elderly patients?

Output: Two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many Japanese studies failed to show any benefit or harm from reducing systolic BP to o140 mm Hg in otherwisehealthy elderly patients?. ### Response: Two.


Instruction: What did the Japanese Trial to AssessOptimal Systol Blood Pressure in Elderly HypertensivePatients (JATOS) aim to assess?

Output: optimal systolic BP inelderly hypertensive patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Japanese Trial to AssessOptimal Systol Blood Pressure in Elderly HypertensivePatients (JATOS) aim to assess?. ### Response: optimal systolic BP inelderly hypertensive patients.


Instruction: What is the acronym for Elderly HypertensivePatients?

Output: JATOS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Elderly HypertensivePatients?. ### Response: JATOS.


Instruction: How many patients were randomized to'strict' or'mild' BP control?

Output: 4418

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were randomized to'strict' or'mild' BP control?. ### Response: 4418.


Instruction: What was the target systolicBP?

Output: 150/80 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the target systolicBP?. ### Response: 150/80 mm Hg.


Instruction: Patients with SCr of Z1.5 mg/dl(133mmol/l) were excluded as were patients with what?

Output: multipleco-morbidities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with SCr of Z1.5 mg/dl(133mmol/l) were excluded as were patients with what?. ### Response: multipleco-morbidities.


Instruction: What should those with genetic lipid dis-orders consider consulting before starting the pregnancy?

Output: a clinician with lipid expertise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should those with genetic lipid dis-orders consider consulting before starting the pregnancy?. ### Response: a clinician with lipid expertise.


Instruction: What are some conditions specific to women?

Output: hyper -tensive disorders during pregnancy, preeclampsia, gestational diabetes mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some conditions specific to women?. ### Response: hyper -tensive disorders during pregnancy, preeclampsia, gestational diabetes mellitus.


Instruction: What have been shown to increase ASCVD risk?

Output: .3-14)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have been shown to increase ASCVD risk?. ### Response: .3-14).


Instruction: What are preeclampsia and premature menopause as risk-enhancing factors for statin therapy?

Output: increase ASCVD risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are preeclampsia and premature menopause as risk-enhancing factors for statin therapy?. ### Response: increase ASCVD risk.


Instruction: What is the risk of ASCVD in the same range as other risk-enhancing factors?

Output: preeclampsia and premature menopause

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of ASCVD in the same range as other risk-enhancing factors?. ### Response: preeclampsia and premature menopause.


Instruction: The mechanism or cause of preterm birth is often unknown; therefore, it is difficult to rou-tinely include this condition as what?

Output: a risk-enhancing factor for statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The mechanism or cause of preterm birth is often unknown; therefore, it is difficult to rou-tinely include this condition as what?. ### Response: a risk-enhancing factor for statin therapy.


Instruction: What type of diabetes mellitus predisposes a woman to metabolic diabetes?

Output: gestational

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diabetes mellitus predisposes a woman to metabolic diabetes?. ### Response: gestational.


Instruction: What predisposes a woman to metabolic syndrome or diabetes mellitus?

Output: gesta-tional diabetes mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What predisposes a woman to metabolic syndrome or diabetes mellitus?. ### Response: gesta-tional diabetes mellitus.


Instruction: What are these already identified as risk-enhancing or major ASCVD risk factors?

Output: gesta-tional diabetes mellitus predisposes a woman to metabolic syndrome or diabetes mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are these already identified as risk-enhancing or major ASCVD risk factors?. ### Response: gesta-tional diabetes mellitus predisposes a woman to metabolic syndrome or diabetes mellitus.


Instruction: After pregnancy and through the life course of every woman, what should be obtained?

Output: a thorough pregnancy history

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: After pregnancy and through the life course of every woman, what should be obtained?. ### Response: a thorough pregnancy history.


Instruction: What should be obtained and risk factors and risk-enhancing factors identified?

Output: a thorough pregnancy history

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be obtained and risk factors and risk-enhancing factors identified?. ### Response: a thorough pregnancy history.


Instruction: Interventions should include what to reduce ASCVD risk?

Output: aggres-sive lifestyle counseling

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Interventions should include what to reduce ASCVD risk?. ### Response: aggres-sive lifestyle counseling.


Instruction: When appropriate, what should be considered?

Output: statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When appropriate, what should be considered?. ### Response: statin therapy.


Instruction: What should be considered in the context of a risk discussion?

Output: Decisions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered in the context of a risk discussion?. ### Response: Decisions.


Instruction: What should decisions take into consideration?

Output: an informed patient preference

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should decisions take into consideration?. ### Response: an informed patient preference.


Instruction: All statins are currently contraindicated in pregnant women?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: All statins are currently contraindicated in pregnant women?. ### Response: 2.


Instruction: How many cases of malformation were found from first-trimester statin exposure?

Output: 20

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many cases of malformation were found from first-trimester statin exposure?. ### Response: 20.


Instruction: How many severe defects of the central nervous system were found?

Output: 5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many severe defects of the central nervous system were found?. ### Response: 5.


Instruction: What type of statin was used in all cases of adverse birth outcomes?

Output: lipophilic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of statin was used in all cases of adverse birth outcomes?. ### Response: lipophilic.


Instruction: What type of pravastatin was used in pregnancy?

Output: hydrophilic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of pravastatin was used in pregnancy?. ### Response: hydrophilic.


Instruction: How many infants were exposed to pravastin?

Output: 14

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many infants were exposed to pravastin?. ### Response: 14.


Instruction: What was the name of the drug used in the study?

Output: lipophilic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the drug used in the study?. ### Response: lipophilic.


Instruction: Why was there no malformation in the 14 infants exposed?

Output: pravastatin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was there no malformation in the 14 infants exposed?. ### Response: pravastatin.


Instruction: Pravastatin is under study for the prevention of what?

Output: preeclampsia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Pravastatin is under study for the prevention of what?. ### Response: preeclampsia.


Instruction: What was observed in a meta-analysis of 6 studies of pregnant women exposed to statins?

Output: no increased risk of birth defects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was observed in a meta-analysis of 6 studies of pregnant women exposed to statins?. ### Response: no increased risk of birth defects.


Instruction: What is an increased risk of Downloaded from http://ahajournals.org by on April 28, 2023?

Output: birth defects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an increased risk of Downloaded from http://ahajournals.org by on April 28, 2023?. ### Response: birth defects.


Instruction: What is associated with the use of nitrates in the setting of HFpEF?

Output: a signal of harm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with the use of nitrates in the setting of HFpEF?. ### Response: a signal of harm.


Instruction: What should be avoided in most situations?

Output: The use of nitrates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be avoided in most situations?. ### Response: The use of nitrates.


Instruction: Alpha blockers, beta blockers and calcium channel blockers are examples of what?

Output: antihypertensive agents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Alpha blockers, beta blockers and calcium channel blockers are examples of what?. ### Response: antihypertensive agents.


Instruction: What are some examples of antihypertensive agents?

Output: alpha blockers, beta blockers, and calcium channel blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some examples of antihypertensive agents?. ### Response: alpha blockers, beta blockers, and calcium channel blockers.


Instruction: What is RAAS inhibition with ACE inhibitor, ARB, and ARNI?

Output: preferred choice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is RAAS inhibition with ACE inhibitor, ARB, and ARNI?. ### Response: preferred choice.


Instruction: What would represent the preferred choice?

Output: RAAS inhibition

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would represent the preferred choice?. ### Response: RAAS inhibition.


Instruction: What should drive the ultimate choice of antihypertensive agents?

Output: physician judgment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should drive the ultimate choice of antihypertensive agents?. ### Response: physician judgment.


Instruction: Sleep-Disordered Breathing: Recommendations moved from Section 7.3.1.4, Treatment of Sleep Disorders in the 2013 HF guideline?

Output: 9.6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Sleep-Disordered Breathing: Recommendations moved from Section 7.3.1.4, Treatment of Sleep Disorders in the 2013 HF guideline?. ### Response: 9.6.


Instruction: What is the classification of NYHA class II-IV HF?

Output: formal sleep assessment is reasonable.200,201NEW: Recommendation reflects clinical necessity to distinguish obstructive versus central sleep apnea

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the classification of NYHA class II-IV HF?. ### Response: formal sleep assessment is reasonable.200,201NEW: Recommendation reflects clinical necessity to distinguish obstructive versus central sleep apnea.


Instruction: What are sleep disorders common in?

Output: patients with HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are sleep disorders common in?. ### Response: patients with HF.


Instruction: What is common in patients with HF?

Output: Sleep disorders

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is common in patients with HF?. ### Response: Sleep disorders.


Instruction: What percentage of adults with chronic HF had either central or obstructive sleep apnea?

Output: 61%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of adults with chronic HF had either central or obstructive sleep apnea?. ### Response: 61%.


Instruction: What type of sleep apnea is associated with harm?

Output: central

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of sleep apnea is associated with harm?. ### Response: central.


Instruction: Continuous positive airway pressure improves sleep quality and reduces what index?

Output: apnea-hyp

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Continuous positive airway pressure improves sleep quality and reduces what index?. ### Response: apnea-hyp.


Instruction: What is CPAP?

Output: Continuous positive airway pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CPAP?. ### Response: Continuous positive airway pressure.


Instruction: What does CPAP improve?

Output: sleep quality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CPAP improve?. ### Response: sleep quality.


Instruction: What may be reasonable to improve sleep quality and daytime sleepiness?

Output: CPAP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be reasonable to improve sleep quality and daytime sleepiness?. ### Response: CPAP.


Instruction: New data demonstrate the limited scope of benefit expected from what?

Output: CPAP for obstructive sleep apnea

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: New data demonstrate the limited scope of benefit expected from what?. ### Response: CPAP for obstructive sleep apnea.


Instruction: What did a trial evaluate in patients with sleep apnea?

Output: the impact of CPAP with usual therapy versus usual therapy alone on subsequent cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a trial evaluate in patients with sleep apnea?. ### Response: the impact of CPAP with usual therapy versus usual therapy alone on subsequent cardiovascular events.


Instruction: What was the effect of CPAP with usual therapy on cardiovascular events?

Output: no evidence of benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the effect of CPAP with usual therapy on cardiovascular events?. ### Response: no evidence of benefit.


Instruction: How long was the mean follow-up of the RCT?

Output: 3.7 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the mean follow-up of the RCT?. ### Response: 3.7 years.


Instruction: In a RCT of >2700 patients, there was no evidence of benefit on what?

Output: cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In a RCT of >2700 patients, there was no evidence of benefit on what?. ### Response: cardiovascular events.


Instruction: How long was the mean follow-up for CPAP plus usual care?

Output: 3.7 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the mean follow-up for CPAP plus usual care?. ### Response: 3.7 years.


Instruction: Improvements in sleep quality represented the primary indication for what?

Output: initiating CPAP treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Improvements in sleep quality represented the primary indication for what?. ### Response: initiating CPAP treatment.


Instruction: Atrial fibrillation is a frequent comorbidity noted with what type of HF?

Output: NYHA class II–IV

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atrial fibrillation is a frequent comorbidity noted with what type of HF?. ### Response: NYHA class II–IV.


Instruction: What is a frequent comorbidity noted with HF?

Output: Sleep disorders

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a frequent comorbidity noted with HF?. ### Response: Sleep disorders.


Instruction: What was the use of CPAP for?

Output: improves sleep quality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the use of CPAP for?. ### Response: improves sleep quality.


Instruction: How many patients were in a trial with AF and obstructive sleep apnea?

Output: 10 132

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were in a trial with AF and obstructive sleep apnea?. ### Response: 10 132.


Instruction: What are the most permanent forms of AF than were patients without CPAP?

Output: 205

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the most permanent forms of AF than were patients without CPAP?. ### Response: 205.


Instruction: What is the name of the book that discusses the diagnosis of heart failure?

Output: Chronic Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the book that discusses the diagnosis of heart failure?. ### Response: Chronic Heart Failure.


Instruction: What does NICE 2018 cover?

Output: Chronic Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does NICE 2018 cover?. ### Response: Chronic Heart Failure.


Instruction: Who is the author of Chronic Heart Failure?

Output: NICE 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of Chronic Heart Failure?. ### Response: NICE 2018.


Instruction: What does NT-proBNP measure in people with suspected heart failure?

Output: N-terminal pro -B-type natriuretic peptide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does NT-proBNP measure in people with suspected heart failure?. ### Response: N-terminal pro -B-type natriuretic peptide.


Instruction: What type of peptide carry a risk of heart failure in people?

Output: serum natriuretic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of peptide carry a risk of heart failure in people?. ### Response: serum natriuretic.


Instruction: What does high levels of NT-proBNP carry a poor prognosis?

Output: suspected heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does high levels of NT-proBNP carry a poor prognosis?. ### Response: suspected heart failure.


Instruction: Refer people with suspected heart failure to have specialist assessment and transthoracic echocardiography within how long?

Output: 6  weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Refer people with suspected heart failure to have specialist assessment and transthoracic echocardiography within how long?. ### Response: 6  weeks.


Instruction: How long does it take for a person with suspected heart failure to have a specialist assessm ent and transthoracic echocardiography?

Output: 2 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take for a person with suspected heart failure to have a specialist assessm ent and transthoracic echocardiography?. ### Response: 2 weeks.


Instruction: What is the NT-proBNP level between 400 and 2,000 ng/litre?

Output: 47 to 236  pmol/litre) to have specialist assessm ent and transthoracic echocardiography within 6  weeks. [2018]   5. Be aware that:   an NT-proBNP  level less than 400  ng/litre (47 pmol/litre

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the NT-proBNP level between 400 and 2,000 ng/litre?. ### Response: 47 to 236  pmol/litre) to have specialist assessm ent and transthoracic echocardiography within 6  weeks. [2018]   5. Be aware that:   an NT-proBNP  level less than 400  ng/litre (47 pmol/litre.


Instruction: What does NT-proBNP level in an untreated person make a diagnosis of heart failure less likely?

Output: less than 400  ng/litre

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does NT-proBNP level in an untreated person make a diagnosis of heart failure less likely?. ### Response: less than 400  ng/litre.


Instruction: What does the level of serum natriuretic peptide do?

Output: can have causes other than heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the level of serum natriuretic peptide do?. ### Response: can have causes other than heart failure.


Instruction: What does not differentiate between heart failure with reduced ejection fraction and heart failur e with preserved eject frence?

Output: serum natriuretic peptide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not differentiate between heart failure with reduced ejection fraction and heart failur e with preserved eject frence?. ### Response: serum natriuretic peptide.


Instruction: What does peptide not do?

Output: ifferentiate between heart failure with reduced ejection fraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does peptide not do?. ### Response: ifferentiate between heart failure with reduced ejection fraction.


Instruction: How do people with NT-proBNP levels below 400ng/litre experience heart failure?

Output: untreated person makes a diagnosis of heart failure less likely

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do people with NT-proBNP levels below 400ng/litre experience heart failure?. ### Response: untreated person makes a diagnosis of heart failure less likely.


Instruction: What is 400 ng/litre?

Output: 47 pmol/litre

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is 400 ng/litre?. ### Response: 47 pmol/litre.


Instruction: What is the name of the subspecialty training in heart failure?

Output: NT-proBNP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the subspecialty training in heart failure?. ### Response: NT-proBNP.


Instruction: If there is concern that the symptoms might be related to heart failure, discuss with a physician what?

Output: w ith subspeciality training  in heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: If there is concern that the symptoms might be related to heart failure, discuss with a physician what?. ### Response: w ith subspeciality training  in heart failure.


Instruction: What can reduce levels of serum natriuretic peptides?

Output: obesity, African or African -Caribbean family origin, or treatment with diuretics, angiotensin -converting enzyme (ACE)   inhibitors  , beta -blockers, angiotensin II receptor blockers  (ARBs) or mineralcorticoid receptor antagonist (MRA s)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can reduce levels of serum natriuretic peptides?. ### Response: obesity, African or African -Caribbean family origin, or treatment with diuretics, angiotensin -converting enzyme (ACE)   inhibitors  , beta -blockers, angiotensin II receptor blockers  (ARBs) or mineralcorticoid receptor antagonist (MRA s).


Instruction: What can have causes?

Output: high levels of serum natriuretic peptides

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can have causes?. ### Response: high levels of serum natriuretic peptides.


Instruction: What can high levels of serum natriuretic peptides have other than heart failure?

Output: causes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can high levels of serum natriuretic peptides have other than heart failure?. ### Response: causes.


Instruction: How old is a person over 70 years?

Output: age over 70  years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old is a person over 70 years?. ### Response: age over 70  years.


Instruction: What ischaemia?

Output: left ventricular hypertrophy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What ischaemia?. ### Response: left ventricular hypertrophy.


Instruction: What does tran sthoracic echocardiography exclude?

Output: important valve disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does tran sthoracic echocardiography exclude?. ### Response: important valve disease.


Instruction: What is performed to assess the systolic function of the (left) ventricle and detect intracardiac shunts?

Output: tran sthoracic echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is performed to assess the systolic function of the (left) ventricle and detect intracardiac shunts?. ### Response: tran sthoracic echocardiography.


Instruction: What should be performed on high-resolution equipment?

Output: Transthoracic echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be performed on high-resolution equipment?. ### Response: Transthoracic echocardiography.


Instruction: What should not compromise quality?

Output: Need and demand for these studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not compromise quality?. ### Response: Need and demand for these studies.


Instruction: What year was the rule changed?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the rule changed?. ### Response: 2010.


Instruction: What year did the rule change?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did the rule change?. ### Response: 2010.


Instruction: What is a risk assessment in patients with established SIHD?

Output: 1.8. Vital Importance of Involvement by anInformed Patient

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk assessment in patients with established SIHD?. ### Response: 1.8. Vital Importance of Involvement by anInformed Patient.


Instruction: What is the Vital Importance of Involvement by anInformed Patient?

Output: RecommendationClass I1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Vital Importance of Involvement by anInformed Patient?. ### Response: RecommendationClass I1.


Instruction: How should decisions about diagnostic and therapeutic options be made?

Output: through a process of shared decisionmaking

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How should decisions about diagnostic and therapeutic options be made?. ### Response: through a process of shared decisionmaking.


Instruction: What is the principle of autonomy?

Output: the healthcareprovider is obliged to solicit and respect the patient’s prefer-ences about choice of therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the principle of autonomy?. ### Response: the healthcareprovider is obliged to solicit and respect the patient’s prefer-ences about choice of therapy.


Instruction: Who is obliged to solicit and respect the patient's prefer-ences about choice of therapy?

Output: healthcareprovider

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is obliged to solicit and respect the patient's prefer-ences about choice of therapy?. ### Response: healthcareprovider.


Instruction: What has received limitedstudy?

Output: cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has received limitedstudy?. ### Response: cardiovascular disease.


Instruction: What type of disease has received only limitedstudy?

Output: cardiovascular

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of disease has received only limitedstudy?. ### Response: cardiovascular.


Instruction: What is the concept of shared decision making viewed as?

Output: an approach that ensures that patients remaininvolved in key decisions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the concept of shared decision making viewed as?. ### Response: an approach that ensures that patients remaininvolved in key decisions.


Instruction: This approach leads to what?

Output: higherquality of care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: This approach leads to what?. ### Response: higherquality of care.


Instruction: What must the provider provide to make the most informed decisions possible?

Output: sufficientinformation about the underlying disease process

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must the provider provide to make the most informed decisions possible?. ### Response: sufficientinformation about the underlying disease process.


Instruction: What should patients be encouraged to seek?

Output: additional informa-tion from other sources

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients be encouraged to seek?. ### Response: additional informa-tion from other sources.


Instruction: What should patients be encouraged to seek from other sources?

Output: informa-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients be encouraged to seek from other sources?. ### Response: informa-tion.


Instruction: Who maintains the National Institutes of Health?

Output: on the Internet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who maintains the National Institutes of Health?. ### Response: on the Internet.


Instruction: What do patients often elect when informed about absolute or marginal benefit?

Output: topostpone or forego invasive procedures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do patients often elect when informed about absolute or marginal benefit?. ### Response: topostpone or forego invasive procedures.


Instruction: When informed about absolute or marginal benefit, patients often elect to forego what?

Output: invasive procedures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When informed about absolute or marginal benefit, patients often elect to forego what?. ### Response: invasive procedures.


Instruction: Why could two patients withsimilar pretest probabilities of IHD prefer differentapproaches?

Output: variations in personal beliefs, eco-nomic situation, or stage of life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why could two patients withsimilar pretest probabilities of IHD prefer differentapproaches?. ### Response: variations in personal beliefs, eco-nomic situation, or stage of life.


Instruction: Because of variations in personal beliefs, eco-nomic situation, or stage of life, what could patients prefer?

Output: differentapproaches

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Because of variations in personal beliefs, eco-nomic situation, or stage of life, what could patients prefer?. ### Response: differentapproaches.


Instruction: What is often no single correct approach to any given set of circumstances?

Output: Because of the variation insymptoms and clinical characteristics among patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is often no single correct approach to any given set of circumstances?. ### Response: Because of the variation insymptoms and clinical characteristics among patients.


Instruction: What are the estimated direct and indirect costs of Heart Disease and Coronary Heart Disease?

Output: Billions ofDollars

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the estimated direct and indirect costs of Heart Disease and Coronary Heart Disease?. ### Response: Billions ofDollars.


Instruction: How much did the United States spend on Heart Disease and Coronary Heart Disease in 2010?

Output: Billions ofDollars

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much did the United States spend on Heart Disease and Coronary Heart Disease in 2010?. ### Response: Billions ofDollars.


Instruction: What is the name of the disease that causes heart disease in the UnitedStates?

Output: Coronary Heart Disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease that causes heart disease in the UnitedStates?. ### Response: Coronary Heart Disease.


Instruction: How much money did the US spend on heart disease?

Output: Billions ofDollars

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much money did the US spend on heart disease?. ### Response: Billions ofDollars.


Instruction: What was the cost of lost productivity/mortality in 2010?

Output: 101.4 69.8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the cost of lost productivity/mortality in 2010?. ### Response: 101.4 69.8.


Instruction: Who prepared the estimates for lost future earnings?

Output: Thomas Thom, National Heart, Lung, and BloodInstitute

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who prepared the estimates for lost future earnings?. ### Response: Thomas Thom, National Heart, Lung, and BloodInstitute.


Instruction: What was discounted at 3%?

Output: Lost future earnings of persons who will die in 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was discounted at 3%?. ### Response: Lost future earnings of persons who will die in 2010.


Instruction: Where was the information obtained?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where was the information obtained?. ### Response: http://ahajournals.org.


Instruction: What is NICE 2018 Subject to?

Output: Notice of rights

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE 2018 Subject to?. ### Response: Notice of rights.


Instruction: What is the ISBN for Chronic Heart Failure Monitoring?

Output: 978 -1-4731 -3093 -7 276

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ISBN for Chronic Heart Failure Monitoring?. ### Response: 978 -1-4731 -3093 -7 276.


Instruction: Adherence to intervention Study design Systematic reviews of RCTs What is Clinical evidence?

Output: 8.4.3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Adherence to intervention Study design Systematic reviews of RCTs What is Clinical evidence?. ### Response: 8.4.3.


Instruction: How many studies were included in the Cochrane review?

Output: Forty one

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were included in the Cochrane review?. ### Response: Forty one.


Instruction: What is the name of the Cochrane review?

Output: Forty one studies were included in the Cochrane  review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Cochrane review?. ### Response: Forty one studies were included in the Cochrane  review.


Instruction: What are the names of the reviews?

Output: Cochrane review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the reviews?. ### Response: Cochrane review.


Instruction: Where are the reviews summarized?

Output: Table 90 and Table 91 below

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are the reviews summarized?. ### Response: Table 90 and Table 91 below.


Instruction: What are the summarised studies in Table 90 and Table 91?

Output: Forty one studies were included in the Cochrane  review;15, 19, 23, 25, 28, 33, 40, 41, 48, 57, 61, 66, 88, 89, 92, 96, 100, 125, 128, 129, 131, 134, 178, 183, 190, 204, 228, 275, 276, 285, 286, 297, 305, 314, 317, 344, 360, 362, 364, 372, 376

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the summarised studies in Table 90 and Table 91?. ### Response: Forty one studies were included in the Cochrane  review;15, 19, 23, 25, 28, 33, 40, 41, 48, 57, 61, 66, 88, 89, 92, 96, 100, 125, 128, 129, 131, 134, 178, 183, 190, 204, 228, 275, 276, 285, 286, 297, 305, 314, 317, 344, 360, 362, 364, 372, 376.


Instruction: How many studies were identified for inclusion in the review?

Output: five

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were identified for inclusion in the review?. ### Response: five.


Instruction: What is the summation of studies 7 and 81 in Table 92?

Output: clinical evidence summaries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the summation of studies 7 and 81 in Table 92?. ### Response: clinical evidence summaries.


Instruction: What are the clinical evidence summaries of these studies?

Output: Table 93, Table 94 and Table 95

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the clinical evidence summaries of these studies?. ### Response: Table 93, Table 94 and Table 95.


Instruction: In what appendix is the study selection flow chart?

Output: Appendix  C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what appendix is the study selection flow chart?. ### Response: Appendix  C.


Instruction: What is in Appendix C?

Output: study selection flow chart

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is in Appendix C?. ### Response: study selection flow chart.


Instruction: Where are forest plots located?

Output: Appendix  E

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are forest plots located?. ### Response: Appendix  E.


Instruction: What are GRADE tables located in?

Output: Appendix  H

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are GRADE tables located in?. ### Response: Appendix  H.


Instruction: When was a HTA report published?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was a HTA report published?. ### Response: 2013.


Instruction: What was reviewed in people recently admitted for an exacerbation of heart failure?

Output: structured  telephone support and telemonitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was reviewed in people recently admitted for an exacerbation of heart failure?. ### Response: structured  telephone support and telemonitoring.


Instruction: Why was the Cochrane review prioritised for update over this review?

Output: it included a broader population, was more recently published an d included RCT level data only

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the Cochrane review prioritised for update over this review?. ### Response: it included a broader population, was more recently published an d included RCT level data only.


Instruction: What was included in this review because it included a broader population?

Output: The Cochrane review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was included in this review because it included a broader population?. ### Response: The Cochrane review.


Instruction: How many studies were included in the previous chronic heart failure guideline?

Output: eight

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were included in the previous chronic heart failure guideline?. ### Response: eight.


Instruction: How many of the studies were excluded by the Cochrane review?

Output: Three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many of the studies were excluded by the Cochrane review?. ### Response: Three.


Instruction: What did the Cochrane review include?

Output: randomised trials comparing the effectiveness of telemonitoring and structured telephone support versus usual care153

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Cochrane review include?. ### Response: randomised trials comparing the effectiveness of telemonitoring and structured telephone support versus usual care153.


Instruction: How many RCTs did not have any extractable data?

Output: 48, 376

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs did not have any extractable data?. ### Response: 48, 376.


Instruction: What type of data were excluded from the Cochrane review?

Output: extractable data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of data were excluded from the Cochrane review?. ### Response: extractable data.


Instruction: What kind of data did the structured telephone su pport not have?

Output: extractable

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What kind of data did the structured telephone su pport not have?. ### Response: extractable.


Instruction: What are patients who have recently been admitted to hospital and recruited within the community analysed separately for?

Output: Data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients who have recently been admitted to hospital and recruited within the community analysed separately for?. ### Response: Data.


Instruction: What have we included where the study has not reported this information?

Output: a mixed strata

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have we included where the study has not reported this information?. ### Response: a mixed strata.


Instruction: How were the outcomes of quality of life and adherence to intervention reported by the Cochrane review?

Output: narratively

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How were the outcomes of quality of life and adherence to intervention reported by the Cochrane review?. ### Response: narratively.


Instruction: In the current review, how have the data on the outcomes been included?

Output: narratively

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the current review, how have the data on the outcomes been included?. ### Response: narratively.


Instruction: How are the outcomes reported?

Output: narratively

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are the outcomes reported?. ### Response: narratively.


Instruction: What type of format are the data reported in?

Output: extractable

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of format are the data reported in?. ### Response: extractable.


Instruction: What was reported by the study in an extractable format?

Output: quality of life and adherence data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was reported by the study in an extractable format?. ### Response: quality of life and adherence data.


Instruction: What does patent foramen ovale closure versus medical therapy for cryptogenic stroke: An updated meta-analysis?

Output: ran-domized controlled trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does patent foramen ovale closure versus medical therapy for cryptogenic stroke: An updated meta-analysis?. ### Response: ran-domized controlled trials.


Instruction: doi: 10.1016/j.jns.2018.04.029 497?

Output: doi

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: doi: 10.1016/j.jns.2018.04.029 497?. ### Response: doi.


Instruction: What type of closure is used for secondary stroke prevention?

Output: Percutaneous patent foramen ovale

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of closure is used for secondary stroke prevention?. ### Response: Percutaneous patent foramen ovale.


Instruction: What is the name of the network meta-analysis that has been conducted?

Output: Percutaneous patent foramen ovale closure for secondary stroke prevention: network meta-analysis. Neurology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the network meta-analysis that has been conducted?. ### Response: Percutaneous patent foramen ovale closure for secondary stroke prevention: network meta-analysis. Neurology.


Instruction: How many strokes have been prevented by patent foramen ovale closure?

Output: secondary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes have been prevented by patent foramen ovale closure?. ### Response: secondary.


Instruction: What does patent foramen ovale closure vs. medical therapy for cryptogenic stroke do?

Output: a meta-analysis of ran-domized controlled trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does patent foramen ovale closure vs. medical therapy for cryptogenic stroke do?. ### Response: a meta-analysis of ran-domized controlled trials.


Instruction: What is the name of the meta-analysis of ran-domized controlled trials?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis of ran-domized controlled trials?. ### Response: stroke.


Instruction: What type of closure of patent foramen ovale following cryptogenic stroke: an updated meta-analysis of randomized controlled trials?

Output: Transcatheter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of closure of patent foramen ovale following cryptogenic stroke: an updated meta-analysis of randomized controlled trials?. ### Response: Transcatheter.


Instruction: What does device closure versus medical therapy alone for patent foramen ovale in patients with cryptogenic stroke?

Output: a systematic review and meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does device closure versus medical therapy alone for patent foramen ovale in patients with cryptogenic stroke?. ### Response: a systematic review and meta-analysis.


Instruction: Ann Intern Med. 2018;168:335-342. doi: 10.7326/M17-2679501.

Output: cryptogenic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Ann Intern Med. 2018;168:335-342. doi: 10.7326/M17-2679501.. ### Response: cryptogenic stroke.


Instruction: What type of closure versus medical treatment in stroke patients with patent foramen ovale: a systematic review and meta-analysis?

Output: Percutaneous

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of closure versus medical treatment in stroke patients with patent foramen ovale: a systematic review and meta-analysis?. ### Response: Percutaneous.


Instruction: What year did Ann Intern Med publish 168:343-350?

Output: 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Ann Intern Med publish 168:343-350?. ### Response: 2018.


Instruction: Percutaneous closure versus medical therapy for stroke with patent foramen ovale: a systematic re-view and meta-analysis.

Output: Zhang XL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Percutaneous closure versus medical therapy for stroke with patent foramen ovale: a systematic re-view and meta-analysis.. ### Response: Zhang XL.


Instruction: BMC Cardiovasc Disord. 2018;18:45.

Output: Percutaneous closure versus medical therapy for stroke with patent foramen ovale: a systematic re-view and meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: BMC Cardiovasc Disord. 2018;18:45.. ### Response: Percutaneous closure versus medical therapy for stroke with patent foramen ovale: a systematic re-view and meta-analysis.


Instruction: Palaiodimos L, Kokkinidis DG, Faillace RT, Foley TR, Dangas GD, Price MJ, Mastoris I. What type of closure is used for stroke?

Output: Percutaneous

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Palaiodimos L, Kokkinidis DG, Faillace RT, Foley TR, Dangas GD, Price MJ, Mastoris I. What type of closure is used for stroke?. ### Response: Percutaneous.


Instruction: What is the difference between percutaneous closure of patent foramen ovale vs. medical treatment for patients with history of cryptogenic stroke?

Output: Device closure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between percutaneous closure of patent foramen ovale vs. medical treatment for patients with history of cryptogenic stroke?. ### Response: Device closure.


Instruction: What was the name of the systematic review and meta-analysis of randomized controlled trials?

Output: Percutaneous closure of patent foramen ovale

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the systematic review and meta-analysis of randomized controlled trials?. ### Response: Percutaneous closure of patent foramen ovale.