Instruction: In what year did myocardial infarction 38 occur?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did myocardial infarction 38 occur?. ### Response: 2012.


Instruction: What is the name of the 2012 issue of Circulation?

Output: 125

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2012 issue of Circulation?. ### Response: 125.


Instruction: How did Sabatine MS, Morrow DA, de Lemos JA, et al. detect acute changes in circulating troponin in the setting of transient stress test-induced ischaemia using an ultrasensitive assay?

Output: TIMI 35

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Sabatine MS, Morrow DA, de Lemos JA, et al. detect acute changes in circulating troponin in the setting of transient stress test-induced ischaemia using an ultrasensitive assay?. ### Response: TIMI 35.


Instruction: How is troponin T detected in the general population?

Output: highly sensitive assay

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is troponin T detected in the general population?. ### Response: highly sensitive assay.


Instruction: What is the name of the assay used to determine the association between cardiac structure and mortality risk?

Output: highly sensitive

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the assay used to determine the association between cardiac structure and mortality risk?. ### Response: highly sensitive.


Instruction: When did JAMA issue 304?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did JAMA issue 304?. ### Response: 2010.


Instruction: What is the name of the textbook of clinical chemistry and Molecular Diagnostics?

Output: Tietz Textbook

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the textbook of clinical chemistry and Molecular Diagnostics?. ### Response: Tietz Textbook.


Instruction: Where is the Tietz Textbook of Clinical Chemistry and Diagnostics published?

Output: Elsevier/Saunders

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the Tietz Textbook of Clinical Chemistry and Diagnostics published?. ### Response: Elsevier/Saunders.


Instruction: What does Chemistry and Molecular Diagnostics cover?

Output: Cardiac troponins in renal insufficiency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Chemistry and Molecular Diagnostics cover?. ### Response: Cardiac troponins in renal insufficiency.


Instruction: What does Freda BJ, Tang WH, Van LF, et al. do with cardiac troponins in renal insufficiency?

Output: review and clinical implications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Freda BJ, Tang WH, Van LF, et al. do with cardiac troponins in renal insufficiency?. ### Response: review and clinical implications.


Instruction: When did J Am Coll Cardiol issue 40:2065–71?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J Am Coll Cardiol issue 40:2065–71?. ### Response: 2002.


Instruction: What is the name of the drug used to treat patients with acute coronary syn-drome and normal high-sensitivity troponin?

Output: Prasugrel-Thrombolysis in Myocardial Infarction 38). Circulation. 2012;125:577–83. 176. Sabatine MS, Morrow DA, de Lemos JA, et al. Detection of acute changes in circulating troponin in the setting of transient stress test-induced myocardial ischaemia using an ultrasensitive assay: results from TIMI 35. Eur Heart J. 2009;30:162–9. 177. de Lemos JA, Drazner MH, Omland T, et al. Association of troponin T

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used to treat patients with acute coronary syn-drome and normal high-sensitivity troponin?. ### Response: Prasugrel-Thrombolysis in Myocardial Infarction 38). Circulation. 2012;125:577–83. 176. Sabatine MS, Morrow DA, de Lemos JA, et al. Detection of acute changes in circulating troponin in the setting of transient stress test-induced myocardial ischaemia using an ultrasensitive assay: results from TIMI 35. Eur Heart J. 2009;30:162–9. 177. de Lemos JA, Drazner MH, Omland T, et al. Association of troponin T.


Instruction: When did Apple FS, Murakami MM, Pearce LA, et al. study the predictive value of car -diac troponine I and T for subsequent death in end-stage renal disease?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Apple FS, Murakami MM, Pearce LA, et al. study the predictive value of car -diac troponine I and T for subsequent death in end-stage renal disease?. ### Response: 2002.


Instruction: What year did Circulation. 2002;106:2941-5.

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Circulation. 2002;106:2941-5.. ### Response: 2002.


Instruction: What year did 106:2941–5 appear?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did 106:2941–5 appear?. ### Response: 2002.


Instruction: What is the IFCC Committee for Standardization of Markers of Cardiac Damage Laboratory Medicine Practice Guidelines: analytical issues for biochemical markers of acute coronary syndromes?

Output: National Academy of Clinical Biochemistry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the IFCC Committee for Standardization of Markers of Cardiac Damage Laboratory Medicine Practice Guidelines: analytical issues for biochemical markers of acute coronary syndromes?. ### Response: National Academy of Clinical Biochemistry.


Instruction: How to use high-sensitivity car-diac troponins in acute cardiac care?

Output: 184

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How to use high-sensitivity car-diac troponins in acute cardiac care?. ### Response: 184.


Instruction: What is the global need to define?

Output: normality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the global need to define?. ### Response: normality.


Instruction: What is the per -centile value of cardiac troponin?

Output: 99th

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the per -centile value of cardiac troponin?. ### Response: 99th.


Instruction: What does Fleming SM, O'Gorman T, Finn J, et al. do in preeclampsia and gestational hypertension?

Output: Cardiac troponin I

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Fleming SM, O'Gorman T, Finn J, et al. do in preeclampsia and gestational hypertension?. ### Response: Cardiac troponin I.


Instruction: What are troponin I and cystatin C in preeclampsia?

Output: serum cardiac

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are troponin I and cystatin C in preeclampsia?. ### Response: serum cardiac.


Instruction: When did Clin Chim Acta issue 374:168-9?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Clin Chim Acta issue 374:168-9?. ### Response: 2006.


Instruction: What is the name of the journal that published the study?

Output: JAMA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that published the study?. ### Response: JAMA.


Instruction: How did Joyal D, Leya F, Koh M, et al. determine troponine I levels?

Output: patients with pre-eclampsia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Joyal D, Leya F, Koh M, et al. determine troponine I levels?. ### Response: patients with pre-eclampsia.


Instruction: What is a marker of decongestion, dyspnea relief, and clinical outcomes among patients hospitalized with acute heart failure?

Output: C-reactive protein

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a marker of decongestion, dyspnea relief, and clinical outcomes among patients hospitalized with acute heart failure?. ### Response: C-reactive protein.


Instruction: What does NT-ProBNP reduction predict during hospital stay?

Output: long-term mortality and readmission

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does NT-ProBNP reduction predict during hospital stay?. ### Response: long-term mortality and readmission.


Instruction: What predicts long-term mortality and readmission in heart failure patients?

Output: NT-ProBNP reduction percent-age during hospital stay

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What predicts long-term mortality and readmission in heart failure patients?. ### Response: NT-ProBNP reduction percent-age during hospital stay.


Instruction: What is NT-ProBNP reduction percentage during admission for acute decompensated heart failure?

Output: long-term cardiovascular mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NT-ProBNP reduction percentage during admission for acute decompensated heart failure?. ### Response: long-term cardiovascular mortality.


Instruction: What is a predictor of improvement and readmission in heart failure?

Output: C-reactive protein

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a predictor of improvement and readmission in heart failure?. ### Response: C-reactive protein.


Instruction: What is the prognostic value of estab-lished and novel biomarkers in patients?

Output: galec-tin-3, a novel marker of fibrosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the prognostic value of estab-lished and novel biomarkers in patients?. ### Response: galec-tin-3, a novel marker of fibrosis.


Instruction: What does PRIDE stand for?

Output: Pro-Brain Natriuretic Peptide Investigation of Dyspnea in the Emergency Department

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does PRIDE stand for?. ### Response: Pro-Brain Natriuretic Peptide Investigation of Dyspnea in the Emergency Department.


Instruction: What is the name of the program used to measure the inter -leukin family member ST2?

Output: International ST2 Consensus Panel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the program used to measure the inter -leukin family member ST2?. ### Response: International ST2 Consensus Panel.


Instruction: What is PRIDE?

Output: Pro-Brain Natriuretic Peptide Investigation of Dyspnea in the Emergency Department

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PRIDE?. ### Response: Pro-Brain Natriuretic Peptide Investigation of Dyspnea in the Emergency Department.


Instruction: When was the PRIDE study conducted?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the PRIDE study conducted?. ### Response: 2007.


Instruction: What is ST2 a predictor of in patients with heart failure relative to?

Output: left ventricular ejection fraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ST2 a predictor of in patients with heart failure relative to?. ### Response: left ventricular ejection fraction.


Instruction: What was the 2011 Am J Cardiol. 107:259-67?

Output: Usefulness of soluble concentrations of interleukin family member ST2 as predictor of mortality in patients with acutely decompensated heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 2011 Am J Cardiol. 107:259-67?. ### Response: Usefulness of soluble concentrations of interleukin family member ST2 as predictor of mortality in patients with acutely decompensated heart failure.


Instruction: What is Galectin-3 called in patients with heart failure?

Output: galec-tin-3, a novel marker of fibrosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Galectin-3 called in patients with heart failure?. ### Response: galec-tin-3, a novel marker of fibrosis.


Instruction: What is the name of the drug that affects cardiac struc-ture and function?

Output: Galectin-3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug that affects cardiac struc-ture and function?. ### Response: Galectin-3.


Instruction: In what year did Eur J Heart Fail issue 12:826-832?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did Eur J Heart Fail issue 12:826-832?. ### Response: 2010.


Instruction: What is a novel marker of fibrosis?

Output: galec-tin-3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a novel marker of fibrosis?. ### Response: galec-tin-3.


Instruction: What is the predictive value of plasma galectin-3 levels in heart failure with reduced and preserved ejection fraction?

Output: renal insufficiency and survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the predictive value of plasma galectin-3 levels in heart failure with reduced and preserved ejection fraction?. ### Response: renal insufficiency and survival.


Instruction: What is galec-tin-3?

Output: a novel marker of fibrosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is galec-tin-3?. ### Response: a novel marker of fibrosis.


Instruction: When did the DEAL-HF study take place?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the DEAL-HF study take place?. ### Response: 2010.


Instruction: How does galectin-3 levels predict renal insufficiency and survival?

Output: Usefulness of plasma galectin-3 levels in systolic heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does galectin-3 levels predict renal insufficiency and survival?. ### Response: Usefulness of plasma galectin-3 levels in systolic heart failure.


Instruction: What predicts renal insufficiency and survival?

Output: Usefulness of plasma galectin-3 levels in systolic heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What predicts renal insufficiency and survival?. ### Response: Usefulness of plasma galectin-3 levels in systolic heart failure.


Instruction: What is systolic heart failure used to predict?

Output: renal insufficiency and survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is systolic heart failure used to predict?. ### Response: renal insufficiency and survival.


Instruction: When did 108:385–90 appear in Am J Cardiol?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did 108:385–90 appear in Am J Cardiol?. ### Response: 2011.


Instruction: How did Tang WH, Wu Y, Grodin JL, et al. determine the prognostic value of Baseline and changes in Circulating Soluble ST2 levels?

Output: the International ST2 Consensus Panel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Tang WH, Wu Y, Grodin JL, et al. determine the prognostic value of Baseline and changes in Circulating Soluble ST2 levels?. ### Response: the International ST2 Consensus Panel.


Instruction: Decompensated heart failure. 2016;4:68–77.

Output: J Am Coll Cardiol HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Decompensated heart failure. 2016;4:68–77.. ### Response: J Am Coll Cardiol HF.


Instruction: The International ST2 Consensus Panel. 2015;115:26B–31B.

Output: Am J Cardiol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The International ST2 Consensus Panel. 2015;115:26B–31B.. ### Response: Am J Cardiol.


Instruction: What was significantly reduced with statin therapy?

Output: all-cause mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was significantly reduced with statin therapy?. ### Response: all-cause mortality.


Instruction: A Markov analysis evaluated the risks and ben-efits of what?

Output: statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A Markov analysis evaluated the risks and ben-efits of what?. ### Response: statin therapy.


Instruction: What should be considered in patients with ICH?

Output: Anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered in patients with ICH?. ### Response: Anticoagulation.


Instruction: What were statin use and age independently associated with in ICH patients?

Output: the presence and number of microbleeds

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were statin use and age independently associated with in ICH patients?. ### Response: the presence and number of microbleeds.


Instruction: What was associated with early neurologi-cal improvement and reduced microbleeds?

Output: continued statin use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with early neurologi-cal improvement and reduced microbleeds?. ### Response: continued statin use.


Instruction: In patients with ICH, what was considered in patients with lobar ICH?

Output: avoidance of statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with ICH, what was considered in patients with lobar ICH?. ### Response: avoidance of statins.


Instruction: What was associated with early neurologi-cal improvement and reduced 6-month mortality in a small retrospective study?

Output: continued statin use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with early neurologi-cal improvement and reduced 6-month mortality in a small retrospective study?. ### Response: continued statin use.


Instruction: There are no data on whether the reported propensity for ICH with statin use is what?

Output: dose depen-dent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There are no data on whether the reported propensity for ICH with statin use is what?. ### Response: dose depen-dent.


Instruction: What should be continued or discontinued in ICH patients?

Output: anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be continued or discontinued in ICH patients?. ### Response: anticoagulation.


Instruction: What are the following risk factors for recurrent ICH?

Output: lobar location of the initial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the following risk factors for recurrent ICH?. ### Response: lobar location of the initial.


Instruction: What should be controlled in all ICH patients?

Output: BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be controlled in all ICH patients?. ### Response: BP.


Instruction: How should measures to control BP begin immediately after ICH onset?

Output: (Class I; Level of Evidence A).

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How should measures to control BP begin immediately after ICH onset?. ### Response: (Class I; Level of Evidence A)..


Instruction: What is the long-term goal of BP?

Output: <130 mm Hg systolic and 80 mm Hg diastolic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the long-term goal of BP?. ### Response: <130 mm Hg systolic and 80 mm Hg diastolic.


Instruction: What is the long-term goal of BP 130 mm Hg systolic?

Output: reduced 6-month mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the long-term goal of BP 130 mm Hg systolic?. ### Response: reduced 6-month mortality.


Instruction: What type of sleep is obstructive?

Output: obstruc-tive sleep apnea

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of sleep is obstructive?. ### Response: obstruc-tive sleep apnea.


Instruction: What is a class IIa; Level of Evidence B?

Output: stolic and 80 mm Hg diastolic is reasonable

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a class IIa; Level of Evidence B?. ### Response: stolic and 80 mm Hg diastolic is reasonable.


Instruction: What is probably recommended as a treatment for nonvalvular atrial fibrillation after warfarin-associated spontaneous lobar ICH?

Output: Avoidance of long-term anticoagulation with warfa-rin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is probably recommended as a treatment for nonvalvular atrial fibrillation after warfarin-associated spontaneous lobar ICH?. ### Response: Avoidance of long-term anticoagulation with warfa-rin.


Instruction: What is recommended after warfarin-associated spontaneous lobar ICH because of the relatively high risk of recurrence?

Output: Avoidance of long-term anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended after warfarin-associated spontaneous lobar ICH because of the relatively high risk of recurrence?. ### Response: Avoidance of long-term anticoagulation.


Instruction: Anticoagulation after nonlobar ICH and antiplate-let monotherapy might be considered when there are strong indications for these agents?

Output: Anticoagulation after nonlobar ICH and antiplate-let monotherapy after any ICH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Anticoagulation after nonlobar ICH and antiplate-let monotherapy might be considered when there are strong indications for these agents?. ### Response: Anticoagulation after nonlobar ICH and antiplate-let monotherapy after any ICH.


Instruction: What is Class IIb?

Output: Level of Evidence B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Class IIb?. ### Response: Level of Evidence B.


Instruction: What is the optimal timing to resume oral anticoagula-tion after anticoagulant-related ICH?

Output: uncertain

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the optimal timing to resume oral anticoagula-tion after anticoagulant-related ICH?. ### Response: uncertain.


Instruction: For how long is it possible to avoid oral coagulation for patients without mechanical heart valves?

Output: 4 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For how long is it possible to avoid oral coagulation for patients without mechanical heart valves?. ### Response: 4 weeks.


Instruction: What might decrease the risk of ICH recurrence in patients without mechanical heart valves?

Output: Avoidance of oral anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What might decrease the risk of ICH recurrence in patients without mechanical heart valves?. ### Response: Avoidance of oral anticoagulation.


Instruction: What can be restarted in the days after ICH?

Output: aspirin monotherapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be restarted in the days after ICH?. ### Response: aspirin monotherapy.


Instruction: What is NICE 2018?

Output: Chronic Heart Failure  Monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE 2018?. ### Response: Chronic Heart Failure  Monitoring.


Instruction: What is the mean age of the participants?

Output: 60 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the mean age of the participants?. ### Response: 60 years.


Instruction: How old are people discharged from hospital with HF?

Output: ≥50 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old are people discharged from hospital with HF?. ### Response: ≥50 years.


Instruction: What type of support does Rainville provide?

Output: Structured telephone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of support does Rainville provide?. ### Response: Structured telephone.


Instruction: How old is the median age with HF?

Output: 74 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old is the median age with HF?. ### Response: 74 years.


Instruction: What is the percentage of HF in the U.S.?

Output: 49/51

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the percentage of HF in the U.S.?. ### Response: 49/51.


Instruction: How many people are attending a HF clinic with LVEF?

Output: <40%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people are attending a HF clinic with LVEF?. ### Response: <40%.


Instruction: What type of clinic has symptoms of HF and LVEF?

Output: HF clinic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of clinic has symptoms of HF and LVEF?. ### Response: HF clinic.


Instruction: How old is the median age in India?

Output: 78/22

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old is the median age in India?. ### Response: 78/22.


Instruction: What is the percentage of India's median age?

Output: 78/22

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the percentage of India's median age?. ### Response: 78/22.


Instruction: How many people were discharged from hospital with HF?

Output: ≥50 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were discharged from hospital with HF?. ### Response: ≥50 years.


Instruction: How old was the median age of people discharged?

Output: 74 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old was the median age of people discharged?. ### Response: 74 years.


Instruction: What type of care was used?

Output: Usual care LVEF≤40%   Mean age: 60 years   M/F(%): 85/15   UK, Poland, Italy  Rainville 1999275 Interve ntion: Structured telephone support  Comparator: Usual care  n=38   People aged ≥50 years discharged from hospital with HF  Mean age: 70 years   M/F(%): 50/50   USA  All-cause mortality   Strata: recent admission  Ramachandran 2007276 Intervention: Structured telephone support  Comparator: Usual care  n=50   People attending a HF clinic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of care was used?. ### Response: Usual care LVEF≤40%   Mean age: 60 years   M/F(%): 85/15   UK, Poland, Italy  Rainville 1999275 Interve ntion: Structured telephone support  Comparator: Usual care  n=38   People aged ≥50 years discharged from hospital with HF  Mean age: 70 years   M/F(%): 50/50   USA  All-cause mortality   Strata: recent admission  Ramachandran 2007276 Intervention: Structured telephone support  Comparator: Usual care  n=50   People attending a HF clinic.


Instruction: How many Hispanic people were hospitalised for HF?

Output: 135

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many Hispanic people were hospitalised for HF?. ### Response: 135.


Instruction: What is the mean age of the people hospitalised?

Output: 74 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the mean age of the people hospitalised?. ### Response: 74 years.


Instruction: What can a repeat TTE examination quantify in noncardiac surgery cases?

Output: the mitral valve gradient and area

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can a repeat TTE examination quantify in noncardiac surgery cases?. ### Response: the mitral valve gradient and area.


Instruction: What can be quantified in perioperative period of patients undergoing non cardiac surgery?

Output: mitral valve gradient and area

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be quantified in perioperative period of patients undergoing non cardiac surgery?. ### Response: mitral valve gradient and area.


Instruction: What is rheumatic MS a slowly progressive disease?

Output: valve stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is rheumatic MS a slowly progressive disease?. ### Response: valve stenosis.


Instruction: What is the latent phase?

Output: an interval typically measured in decades in high-income countries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the latent phase?. ### Response: an interval typically measured in decades in high-income countries.


Instruction: What is the interval measured in decades in high-income countries?

Output: The latent phase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the interval measured in decades in high-income countries?. ### Response: The latent phase.


Instruction: Why is the latent phase measured in shorter periods in low- to middle-in-come countries? What is slow once mild stenosis has developed?

Output: further narrow-ing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is the latent phase measured in shorter periods in low- to middle-in-come countries? What is slow once mild stenosis has developed?. ### Response: further narrow-ing.


Instruction: What is a decrease in valve area per year on average?

Output: 0.1 cm2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a decrease in valve area per year on average?. ### Response: 0.1 cm2.


Instruction: What is the average decrease in valve area per year?

Output: 0.1 cm2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the average decrease in valve area per year?. ### Response: 0.1 cm2.


Instruction: What can be observed even in the absence of a decrease in mitral valve area?

Output: progressive enlarge-ment of the RV and a rise in RV systolic pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be observed even in the absence of a decrease in mitral valve area?. ### Response: progressive enlarge-ment of the RV and a rise in RV systolic pressure.


Instruction: What is an important aspect of dis-ease management even in patients without symp-toms?

Output: at intervals dictated by valve area

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an important aspect of dis-ease management even in patients without symp-toms?. ### Response: at intervals dictated by valve area.


Instruction: What can be obtained in most patients by TTE?

Output: assessment of MS and associ-ated lesions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be obtained in most patients by TTE?. ### Response: assessment of MS and associ-ated lesions.


Instruction: What can sometimes be supplemented by TEE?

Output: Diagnostic Testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can sometimes be supplemented by TEE?. ### Response: Diagnostic Testing.


Instruction: In older patients, what may need to be further sorted?

Output: fac-tors contributing to symptoms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In older patients, what may need to be further sorted?. ### Response: fac-tors contributing to symptoms.


Instruction: What may need to be sorted out?

Output: fac-tors contributing to symptoms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may need to be sorted out?. ### Response: fac-tors contributing to symptoms.


Instruction: What is useful in these patients to further characterize rheumatic MS hemodynamics?

Output: Cardiac catheterization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is useful in these patients to further characterize rheumatic MS hemodynamics?. ### Response: Cardiac catheterization.


Instruction: What is an acceptable substitute for mean LA pressure?

Output: mean pulmonary artery wedge pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an acceptable substitute for mean LA pressure?. ### Response: mean pulmonary artery wedge pressure.


Instruction: What will overestimate the true transmitral gradient because of phase delay and delayed transmission?

Output: LV–to–pulmonary wedge gra-dient

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will overestimate the true transmitral gradient because of phase delay and delayed transmission?. ### Response: LV–to–pulmonary wedge gra-dient.


Instruction: What causes the true transmitral gradient?

Output: phase delay and delayed transmission of pressure changes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes the true transmitral gradient?. ### Response: phase delay and delayed transmission of pressure changes.


Instruction: What can provide useful clinical information?

Output: absolute mean pulmonary artery wedge pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can provide useful clinical information?. ### Response: absolute mean pulmonary artery wedge pressure.


Instruction: The Gorlin equation can be used for an independent calculation of what?

Output: mitral valve area

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The Gorlin equation can be used for an independent calculation of what?. ### Response: mitral valve area.


Instruction: What can be used for an independent calculation of mitral valve area?

Output: The Gorlin equation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be used for an independent calculation of mitral valve area?. ### Response: The Gorlin equation.


Instruction: When was the equation downloaded from http://ahajournals.org?

Output: April 27, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the equation downloaded from http://ahajournals.org?. ### Response: April 27, 2023.


Instruction: How many patients in the exercise training arm had no serious adverse events related to exercise?

Output: patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients in the exercise training arm had no serious adverse events related to exercise?. ### Response: patients.


Instruction: Exercise therapy may be safe in obese patients with HFrEF and HFpEF and may be associated with what?

Output: improvement in both QOL and exercise capacity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Exercise therapy may be safe in obese patients with HFrEF and HFpEF and may be associated with what?. ### Response: improvement in both QOL and exercise capacity.


Instruction: What is sleep apnea, obesity, and HFOSA have a complex interaction with?

Output: HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is sleep apnea, obesity, and HFOSA have a complex interaction with?. ### Response: HF.


Instruction: In the Sleep Heart Health Study, OSA was detected in 37% of patients with what type of HF?

Output: 259

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the Sleep Heart Health Study, OSA was detected in 37% of patients with what type of HF?. ### Response: 259.


Instruction: What is the main risk factor for OSA in men?

Output: obesity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the main risk factor for OSA in men?. ### Response: obesity.


Instruction: What is a major risk factor in men with OSA?

Output: obesity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a major risk factor in men with OSA?. ### Response: obesity.


Instruction: In women with HFrEF, what percentage of OSA are they diagnosed with?

Output: 11% to 26%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In women with HFrEF, what percentage of OSA are they diagnosed with?. ### Response: 11% to 26%.


Instruction: What percentage of patients with HFpEF are obese?

Output: 40% to 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients with HFpEF are obese?. ### Response: 40% to 50%.


Instruction: What may be a factor in the higher prevalence of OSA in this patient population?

Output: The greater associations of HFpEF with obesity and of hypertension with both OSA and obesity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be a factor in the higher prevalence of OSA in this patient population?. ### Response: The greater associations of HFpEF with obesity and of hypertension with both OSA and obesity.


Instruction: No randomized trials have been performed to evaluate the effect of treatment of what?

Output: weight loss

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No randomized trials have been performed to evaluate the effect of treatment of what?. ### Response: weight loss.


Instruction: What is the effect of OSA on longer-term outcomes of mortality and morbidity in patients with HF?

Output: no randomized trials have been performed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of OSA on longer-term outcomes of mortality and morbidity in patients with HF?. ### Response: no randomized trials have been performed.


Instruction: What is associated with an improvement in EF, dyspnea and QOL?

Output: ive airway pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with an improvement in EF, dyspnea and QOL?. ### Response: ive airway pressure.


Instruction: How many short-term studies have suggested that OSA with continuous posi-tive airway pressure is associated?

Output: smaller

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many short-term studies have suggested that OSA with continuous posi-tive airway pressure is associated?. ### Response: smaller.


Instruction: How many obese patients with HF have EF, dyspnea, and QOL?

Output: 235,236,259

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many obese patients with HF have EF, dyspnea, and QOL?. ### Response: 235,236,259.


Instruction: How many patients have BP, diastolic function, and cardiac remodeling?

Output: patients without HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients have BP, diastolic function, and cardiac remodeling?. ### Response: patients without HF.


Instruction: What will weight loss in obese patients result in?

Output: improve symptoms and prognosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will weight loss in obese patients result in?. ### Response: improve symptoms and prognosis.


Instruction: What is an area for future research in patients with OSA and HF?

Output: longer-term outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an area for future research in patients with OSA and HF?. ### Response: longer-term outcomes.


Instruction: There are no specific recommendations for what in the 2013 ACCF/AHA focused update guidelines?

Output: weight loss

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There are no specific recommendations for what in the 2013 ACCF/AHA focused update guidelines?. ### Response: weight loss.


Instruction: What are important risk factors for the devel-opment of HF?

Output: obesity and in-sulin resistance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are important risk factors for the devel-opment of HF?. ### Response: obesity and in-sulin resistance.


Instruction: There are no large-scale studies on the safety or efficacy of weight loss with diet, exer-cise, or bariatric surgery in obese patients?

Output: HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There are no large-scale studies on the safety or efficacy of weight loss with diet, exer-cise, or bariatric surgery in obese patients?. ### Response: HF.


Instruction: What does the writing committee caution against?

Output: the use of ephedra, sibutramine, and other weight-loss prepara-tions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the writing committee caution against?. ### Response: the use of ephedra, sibutramine, and other weight-loss prepara-tions.


Instruction: What does ephedra, sibutramine, and other weight-loss prepara-tions contribute to?

Output: improvement in both QOL and exercise capacity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ephedra, sibutramine, and other weight-loss prepara-tions contribute to?. ### Response: improvement in both QOL and exercise capacity.


Instruction: What does the 2009 AHA scientific statement on promoting self-care in individu-als with HF suggest?

Output: weight loss only if the BMI is >40 kg/m2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the 2009 AHA scientific statement on promoting self-care in individu-als with HF suggest?. ### Response: weight loss only if the BMI is >40 kg/m2.


Instruction: If the BMI is 30 kg/m2, weight loss is not encouraged?

Output: 2013 ACCF/AHA focused update guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: If the BMI is 30 kg/m2, weight loss is not encouraged?. ### Response: 2013 ACCF/AHA focused update guidelines.


Instruction: What is the 2010 Heart Failure Society of America guideline?

Output: weight loss is recommended to improve symptoms and prognosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2010 Heart Failure Society of America guideline?. ### Response: weight loss is recommended to improve symptoms and prognosis.


Instruction: What is recommended to improve symptoms and prognosis of obesity cardiomyopathy and obesity-hy-poventilation syndromes?

Output: weight loss

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended to improve symptoms and prognosis of obesity cardiomyopathy and obesity-hy-poventilation syndromes?. ### Response: weight loss.


Instruction: How many patients had Doppler-catheterization correlation in 1988?

Output: 100

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had Doppler-catheterization correlation in 1988?. ### Response: 100.


Instruction: What predicts out-comes in patients with low gradient severe aortic stenosis and preserved EF?

Output: Velocity ratio

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What predicts out-comes in patients with low gradient severe aortic stenosis and preserved EF?. ### Response: Velocity ratio.


Instruction: What is the name of the study that examined aortic valve calcium scoring in patients with stenosis?

Output: Computed tomography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined aortic valve calcium scoring in patients with stenosis?. ### Response: Computed tomography.


Instruction: What are the results of this study?

Output: Impact of aortic valve calcification, as measured by MDCT, on survival in patients with aortic stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of this study?. ### Response: Impact of aortic valve calcification, as measured by MDCT, on survival in patients with aortic stenosis.


Instruction: What is the outcome in severe, asymptomatic aortic stenosis?

Output: Predictors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the outcome in severe, asymptomatic aortic stenosis?. ### Response: Predictors.


Instruction: What was the N Engl J Med. 2000;343:611-7?

Output: Predictors of outcome in severe, asymptomatic aortic stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the N Engl J Med. 2000;343:611-7?. ### Response: Predictors of outcome in severe, asymptomatic aortic stenosis.


Instruction: How was calcification measured by electron-beam com-puted tomography?

Output: Evaluation and clinical implications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was calcification measured by electron-beam com-puted tomography?. ### Response: Evaluation and clinical implications.


Instruction: What is the correlation between aortic valve calcification and hae-modynamic severity of stenosis?

Output: clinical implication for patients with low ejection fraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the correlation between aortic valve calcification and hae-modynamic severity of stenosis?. ### Response: clinical implication for patients with low ejection fraction.


Instruction: Heart. 2011;97:721–6.

Output: aortic stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Heart. 2011;97:721–6.. ### Response: aortic stenosis.


Instruction: What is measured by MDCT?

Output: Impact of aortic valve calcification

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is measured by MDCT?. ### Response: Impact of aortic valve calcification.


Instruction: What is the impact of aortic valve calcification on survival in patients with stenosis?

Output: Impact of aortic valve calcification, as measured by MDCT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact of aortic valve calcification on survival in patients with stenosis?. ### Response: Impact of aortic valve calcification, as measured by MDCT.


Instruction: How did MDCT measure the impact on survival?

Output: international registry study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did MDCT measure the impact on survival?. ### Response: international registry study.


Instruction: When was the J Am Coll Cardiol 64:1202–13?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol 64:1202–13?. ### Response: 2014.


Instruction: What are EAE/ASE recommendations for clinical practice?

Output: Echocardiographic assessment of valve stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are EAE/ASE recommendations for clinical practice?. ### Response: Echocardiographic assessment of valve stenosis.


Instruction: What is Eur J Echocardiogr. 2009;10:1–25?

Output: Echocardiographic assessment of valve stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Eur J Echocardiogr. 2009;10:1–25?. ### Response: Echocardiographic assessment of valve stenosis.


Instruction: How many adult patients were enrolled in a simultaneous Doppler-catheter correlative study in 1985?

Output: 100

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many adult patients were enrolled in a simultaneous Doppler-catheter correlative study in 1985?. ### Response: 100.


Instruction: What is the name of the prospective study of asymptomatic valvular aortic stenosis?

Output: Otto CM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective study of asymptomatic valvular aortic stenosis?. ### Response: Otto CM.


Instruction: What does Doppler echocardiography do?

Output: Accurate noninvasive quantifica-tion of stenotic aortic valve area

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Doppler echocardiography do?. ### Response: Accurate noninvasive quantifica-tion of stenotic aortic valve area.


Instruction: Doppler echocardiography of the stenotic aortic valve area in adults with symp-tomatic stenosis?

Output: multislice computed tomography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Doppler echocardiography of the stenotic aortic valve area in adults with symp-tomatic stenosis?. ### Response: multislice computed tomography.


Instruction: What is the diagnostic utility and cost-effectiveness of doppler echocardiography?

Output: 23. Otto CM, Pearlman AS. Doppler echocardiography in adults with symp-tomatic aortic stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the diagnostic utility and cost-effectiveness of doppler echocardiography?. ### Response: 23. Otto CM, Pearlman AS. Doppler echocardiography in adults with symp-tomatic aortic stenosis.


Instruction: What is the name of Otto CM's 6th ed. textbook of clinical echocardiography?

Output: The Textbook of Clinical Echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of Otto CM's 6th ed. textbook of clinical echocardiography?. ### Response: The Textbook of Clinical Echocardiography.


Instruction: What is Stewart RAH's title?

Output: 26

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Stewart RAH's title?. ### Response: 26.


Instruction: What did Whalley GA, Minners J, and Jander N do?

Output: Left ventricular systolic and dia-stolic function assessed by tissue Doppler imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Whalley GA, Minners J, and Jander N do?. ### Response: Left ventricular systolic and dia-stolic function assessed by tissue Doppler imaging.


Instruction: What was the outcome of asymp-tomatic aortic stenosis assessed by tissue Doppler imaging?

Output: Left ventricular systolic and dia-stolic function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome of asymp-tomatic aortic stenosis assessed by tissue Doppler imaging?. ### Response: Left ventricular systolic and dia-stolic function.


Instruction: What can be very effective at ensuring patient adherence?

Output: Incorporating these medications into the standard post-PCI order sets and having a detailed discussion of their benefits

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be very effective at ensuring patient adherence?. ### Response: Incorporating these medications into the standard post-PCI order sets and having a detailed discussion of their benefits.


Instruction: What measure harmonizes closely with the corresponding facility-level postprocedural optimal medical therapy composite measure from the ACC.385.8?

Output: PCI.36 Incorporating these medications into the standard post-PCI order sets and having a detailed discussion of their benefits can be very effective at ensuring patient adherence, particularly with statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What measure harmonizes closely with the corresponding facility-level postprocedural optimal medical therapy composite measure from the ACC.385.8?. ### Response: PCI.36 Incorporating these medications into the standard post-PCI order sets and having a detailed discussion of their benefits can be very effective at ensuring patient adherence, particularly with statin therapy.


Instruction: What is the medical therapy composite measure from the ACC.385.8?

Output: postprocedural optimal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the medical therapy composite measure from the ACC.385.8?. ### Response: postprocedural optimal.


Instruction: Cardiac rehabilitation is a multidisciplinary exercise-based out-patient service that has been proven to provide what benefit?

Output: improved functional status, quality of life, medi-cal resource use, and, ultimately, mortality rate reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cardiac rehabilitation is a multidisciplinary exercise-based out-patient service that has been proven to provide what benefit?. ### Response: improved functional status, quality of life, medi-cal resource use, and, ultimately, mortality rate reduction.


Instruction: What are patients with coronary artery disease treated with PCI at high risk of?

Output: recurrent events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients with coronary artery disease treated with PCI at high risk of?. ### Response: recurrent events.


Instruction: What is a vastly underutilized service?

Output: cardiac rehabilitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a vastly underutilized service?. ### Response: cardiac rehabilitation.


Instruction: When will cardiac rehabilitation be available?

Output: May 3, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When will cardiac rehabilitation be available?. ### Response: May 3, 2023.


Instruction: What did Shin IS, Park MS, Cho KH, et al. Comparative validity of depression assessment scales for screening poststroke depression?

Output: 2013;147:186–191

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Shin IS, Park MS, Cho KH, et al. Comparative validity of depression assessment scales for screening poststroke depression?. ### Response: 2013;147:186–191.


Instruction: What did J Affect Disord. 2013;147:186–191. doi: 10.1016/j.jad.2012.10.035 273.

Output: Comparative validity of depression assessment scales for screening poststroke depression

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did J Affect Disord. 2013;147:186–191. doi: 10.1016/j.jad.2012.10.035 273.. ### Response: Comparative validity of depression assessment scales for screening poststroke depression.


Instruction: What was a randomized, controlled trial?

Output: Care management of poststroke depression

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a randomized, controlled trial?. ### Response: Care management of poststroke depression.


Instruction: What is the name of the randomized, controlled trial of management of poststroke depression?

Output: The Preventive Antibiotics in Stroke Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized, controlled trial of management of poststroke depression?. ### Response: The Preventive Antibiotics in Stroke Study.


Instruction: How many people were involved in the PASS study?

Output: 61 274

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were involved in the PASS study?. ### Response: 61 274.


Instruction: What is PASS?

Output: The Preventive Antibiotics in Stroke Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PASS?. ### Response: The Preventive Antibiotics in Stroke Study.


Instruction: Antibiotics in Stroke Study: a pragmatic randomised open-label masked endpoint clinical trial.

Output: PASS investigators. The Preventive Antibiotics in Stroke Study (PASS): a pragmatic randomised open-label masked endpoint clinical trial. Lancet. 2015;385:1519–1526. doi: 10.1016/S0140-6736(14)62456-9 275

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Antibiotics in Stroke Study: a pragmatic randomised open-label masked endpoint clinical trial.. ### Response: PASS investigators. The Preventive Antibiotics in Stroke Study (PASS): a pragmatic randomised open-label masked endpoint clinical trial. Lancet. 2015;385:1519–1526. doi: 10.1016/S0140-6736(14)62456-9 275.


Instruction: What does STROKE-INF do?

Output: Prophylactic anti-biotics after acute stroke for reducing pneumonia in patients with dys-phagia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does STROKE-INF do?. ### Response: Prophylactic anti-biotics after acute stroke for reducing pneumonia in patients with dys-phagia.


Instruction: What is the name of the prospective, cluster-randomised, open-label, masked endpoint, controlled clinical trial of stroke for reducing pneumonia in patients with dys-phagia?

Output: STROKE-INF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective, cluster-randomised, open-label, masked endpoint, controlled clinical trial of stroke for reducing pneumonia in patients with dys-phagia?. ### Response: STROKE-INF.


Instruction: When was the trial downloaded from http://ahajournals.org by?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the trial downloaded from http://ahajournals.org by?. ### Response: April 28, 2023.


Instruction: What type of workup should include noncontrasthead CT?

Output: Acute diagnostic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of workup should include noncontrasthead CT?. ### Response: Acute diagnostic.


Instruction: What should be followed by lumbar puncture?

Output: noncontrasthead CT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be followed by lumbar puncture?. ### Response: noncontrasthead CT.


Instruction: CTA may be considered in the workup of what?

Output: aSAH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: CTA may be considered in the workup of what?. ### Response: aSAH.


Instruction: What may be rea-sonable for the diagnosis of aneurysms?

Output: Magnetic resonance imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be rea-sonable for the diagnosis of aneurysms?. ### Response: Magnetic resonance imaging.


Instruction: What is still recommended if CTA is inconclusive?

Output: DSA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is still recommended if CTA is inconclusive?. ### Response: DSA.


Instruction: What may be rea-sonable for the diagnosis of aSAH in patients with anondiagnostic CT scan?

Output: Magnetic resonance imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be rea-sonable for the diagnosis of aSAH in patients with anondiagnostic CT scan?. ### Response: Magnetic resonance imaging.


Instruction: What should not be used in the acute phase of ischemic stroke?

Output: Heparinoids

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not be used in the acute phase of ischemic stroke?. ### Response: Heparinoids.


Instruction: What does heparinoids appear to increase the risk of without net bene fit?

Output: symptomaticintracranial hemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does heparinoids appear to increase the risk of without net bene fit?. ### Response: symptomaticintracranial hemorrhage.


Instruction: Theoptimal timing of anticoagulation is unknown after what?

Output: acute ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Theoptimal timing of anticoagulation is unknown after what?. ### Response: acute ischemic stroke.


Instruction: What is unknown after acute ischemicstroke?

Output: The optimal timing of anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is unknown after acute ischemicstroke?. ### Response: The optimal timing of anticoagulation.


Instruction: What is indicated as secondary prevention in AF patients with acute stroke withoutcontraindications?

Output: long-term oralanticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is indicated as secondary prevention in AF patients with acute stroke withoutcontraindications?. ### Response: long-term oralanticoagulation.


Instruction: The optimal timing of anticoagulation earlyafter acute stroke is unknown.

Output: earlier than 1 week

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The optimal timing of anticoagulation earlyafter acute stroke is unknown.. ### Response: earlier than 1 week.


Instruction: Early use ofNOACs shows promise but requires testing in what?

Output: randomized controlled trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Early use ofNOACs shows promise but requires testing in what?. ### Response: randomized controlled trials.


Instruction: What shows promise but requires testing in randomized controlled trials?

Output: Early use ofNOACs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What shows promise but requires testing in randomized controlled trials?. ### Response: Early use ofNOACs.


Instruction: What should be bestarted within 2 weeks of acute ischemic stroke?

Output: oral anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be bestarted within 2 weeks of acute ischemic stroke?. ### Response: oral anticoagulation.


Instruction: Infarct size is clinically used to determine what?

Output: anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Infarct size is clinically used to determine what?. ### Response: anticoagulation.


Instruction: What is clinically used to guidetiming of anticoagulation?

Output: infarct size

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is clinically used to guidetiming of anticoagulation?. ### Response: infarct size.


Instruction: What is predictive of a higher risk of early recurrentischemia, hemorrhagic transformation and poor outcome?

Output: infarct size

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is predictive of a higher risk of early recurrentischemia, hemorrhagic transformation and poor outcome?. ### Response: infarct size.


Instruction: Anticoagulation with NOACs soon after stroke has not been tested in randomized trials, but shows promise in what?

Output: observational studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Anticoagulation with NOACs soon after stroke has not been tested in randomized trials, but shows promise in what?. ### Response: observational studies.


Instruction: What causes about 1 in 10 strokes?

Output: Spontaneous (nontraumatic) intracranial hemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes about 1 in 10 strokes?. ### Response: Spontaneous (nontraumatic) intracranial hemorrhage.


Instruction: What is the most feared complication of antithrombotic therapy?

Output: ICH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most feared complication of antithrombotic therapy?. ### Response: ICH.


Instruction: What percentage of people with ICH are taking Evidence-Based Medicine?

Output: 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of people with ICH are taking Evidence-Based Medicine?. ### Response: 50%.


Instruction: How many people with ICH are taking Evidence-Based Medicine?

Output: 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people with ICH are taking Evidence-Based Medicine?. ### Response: 50%.


Instruction: What is the number 5 CHEST NOVEMBER 2018?

Output: 154

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the number 5 CHEST NOVEMBER 2018?. ### Response: 154.


Instruction: What did the International VT Ablation Center Collaborative Group study look at?

Output: Contrast-enhanced MRI-derived scar patterns and associated ventricular tachycardias in nonischemic cardiomyopathy: implications for the ablation strategy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the International VT Ablation Center Collaborative Group study look at?. ### Response: Contrast-enhanced MRI-derived scar patterns and associated ventricular tachycardias in nonischemic cardiomyopathy: implications for the ablation strategy.


Instruction: What did Piers SR, Tao Q, Tvan Huls van Taxis CF, et al. have an impact on?

Output: ablation strategy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Piers SR, Tao Q, Tvan Huls van Taxis CF, et al. have an impact on?. ### Response: ablation strategy.


Instruction: What is the name of the ventricular tachycardia in cardiac sarcoidosis?

Output: Arrhythmogenic Right Ventricular Cardiomyopathy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the ventricular tachycardia in cardiac sarcoidosis?. ### Response: Arrhythmogenic Right Ventricular Cardiomyopathy.


Instruction: What are the characteristics of intramu-ral scar in patients with nonischemic cardiomyopathy and relation to intramuralventricular arrhythmias?

Output: Contrast-enhanced MRI-derived scar patterns

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the characteristics of intramu-ral scar in patients with nonischemic cardiomyopathy and relation to intramuralventricular arrhythmias?. ### Response: Contrast-enhanced MRI-derived scar patterns.


Instruction: What is the treatment approach to ventricular tachycardia in cardiac sarcoidosis?

Output: Systematic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the treatment approach to ventricular tachycardia in cardiac sarcoidosis?. ### Response: Systematic.


Instruction: What is Arrhythmogenic Right Ventricular Cardiomyopathy S7.3-1?

Output: Systematic treatment approach to ventricular tachycardia in cardiac sarcoidosis. Circ Arrhythm Electrophysiol. 2014;7:407–13.7.3. Arrhythmogenic Right Ventricular Cardiomyopathy S7.3-1. Groeneweg JA, Bhonsale A, James CA, et al. Clinical presentation, long-term follow-up, and outcomes of 1001 arrhythmogenic right ventricular dysplasia/cardiomyopathy patients and family members

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Arrhythmogenic Right Ventricular Cardiomyopathy S7.3-1?. ### Response: Systematic treatment approach to ventricular tachycardia in cardiac sarcoidosis. Circ Arrhythm Electrophysiol. 2014;7:407–13.7.3. Arrhythmogenic Right Ventricular Cardiomyopathy S7.3-1. Groeneweg JA, Bhonsale A, James CA, et al. Clinical presentation, long-term follow-up, and outcomes of 1001 arrhythmogenic right ventricular dysplasia/cardiomyopathy patients and family members.


Instruction: How many arrhythmogenic right ventricular dysplasia/cardiomyopathy patients and family members were evaluated?

Output: 1001

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many arrhythmogenic right ventricular dysplasia/cardiomyopathy patients and family members were evaluated?. ### Response: 1001.


Instruction: What is a practical guide for physicians for genetics of arrhythmogenic right ventricular cardiomyopathy?

Output: Diagnosis of arrhythmo-genic right ventricular cardiomyopathy/dysplasia: proposed modifi-cation of the task force criteria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a practical guide for physicians for genetics of arrhythmogenic right ventricular cardiomyopathy?. ### Response: Diagnosis of arrhythmo-genic right ventricular cardiomyopathy/dysplasia: proposed modifi-cation of the task force criteria.


Instruction: What is the impact of genetics and revised task?

Output: Familial evaluation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact of genetics and revised task?. ### Response: Familial evaluation.


Instruction: What is the impact of genetics and revised task force criteria?

Output: Familial evaluation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact of genetics and revised task force criteria?. ### Response: Familial evaluation.


Instruction: Circulation. 2011;123:2701–9. S7.3-4. te Riele AS, James CA, Groeneweg JA, et al. Approach to family screening in what?

Output: arrhythmogenic right ventricular dysplasia/cardiomy-opathy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation. 2011;123:2701–9. S7.3-4. te Riele AS, James CA, Groeneweg JA, et al. Approach to family screening in what?. ### Response: arrhythmogenic right ventricular dysplasia/cardiomy-opathy.


Instruction: What did Pursnani A, Sharma UC, et al. effect of the 2010 task force criteria on reclassification of cardiovascular magnetic resonance criteria for arrhythmogenic right ventricular cardiomyopathy?

Output: Approach to family screening

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Pursnani A, Sharma UC, et al. effect of the 2010 task force criteria on reclassification of cardiovascular magnetic resonance criteria for arrhythmogenic right ventricular cardiomyopathy?. ### Response: Approach to family screening.


Instruction: What did Marcus FI, McKenna WJ, Sherrill D, and others do?

Output: proposed modifi-cation of the task force criteria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Marcus FI, McKenna WJ, Sherrill D, and others do?. ### Response: proposed modifi-cation of the task force criteria.


Instruction: What was proposed modifi-cation of the task force criteria?

Output: Diagnosis of arrhythmo-genic right ventricular cardiomyopathy/dysplasia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was proposed modifi-cation of the task force criteria?. ### Response: Diagnosis of arrhythmo-genic right ventricular cardiomyopathy/dysplasia.


Instruction: Circulation. 2010;121:1533–41.

Output: S7.3-7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation. 2010;121:1533–41.. ### Response: S7.3-7.


Instruction: What is the Incremental value of cardiac magnetic resonance imaging in arrhythmic risk stratifica-tion?

Output: S7.3-7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Incremental value of cardiac magnetic resonance imaging in arrhythmic risk stratifica-tion?. ### Response: S7.3-7.


Instruction: What is a desmosomal mutation carrier?

Output: arrhythmogenic right ventricular dysplasia/cardiomyopa-thy-associated

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a desmosomal mutation carrier?. ### Response: arrhythmogenic right ventricular dysplasia/cardiomyopa-thy-associated.


Instruction: What is the JACC Cardiovasc Imag 20114:282–7?

Output: S7.3-6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the JACC Cardiovasc Imag 20114:282–7?. ### Response: S7.3-6.


Instruction: What is the name of the patient with arrhythmogenic right ventricular dysplasia/cardiomyopathy under -going implantable cardioverter-defibrillator implantation for pri-mary prevention?

Output: Bhonsale

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the patient with arrhythmogenic right ventricular dysplasia/cardiomyopathy under -going implantable cardioverter-defibrillator implantation for pri-mary prevention?. ### Response: Bhonsale.


Instruction: When was the J Am Coll Cardiol. 201158:1485–96?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol. 201158:1485–96?. ### Response: 2013.


Instruction: What is the main objective of hypertensiontreatmentistoattainandmaintaingoalBP?

Output: Recommendation 9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the main objective of hypertensiontreatmentistoattainandmaintaingoalBP?. ### Response: Recommendation 9.


Instruction: IfgoalBPisnotreachedwithinamonthoftreatment,increasethedoseoftheinitialdrugoraddaseconddrugfromoneoftheclassesinrecommendation6(thiazide-typediuretic,CCB,ACEI, orARB)?

Output: IfgoalBPisnotreachedwithinamonthoftreatment,increasethedoseoftheinitialdrugoraddaseconddrugfromoneoftheclassesinrecom-mendation6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: IfgoalBPisnotreachedwithinamonthoftreatment,increasethedoseoftheinitialdrugoraddaseconddrugfromoneoftheclassesinrecommendation6(thiazide-typediuretic,CCB,ACEI, orARB)?. ### Response: IfgoalBPisnotreachedwithinamonthoftreatment,increasethedoseoftheinitialdrugoraddaseconddrugfromoneoftheclassesinrecom-mendation6.


Instruction: What can develop despite the maintenance of appropriate serum drug concentrations during treatment?

Output: vestibular toxicity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can develop despite the maintenance of appropriate serum drug concentrations during treatment?. ### Response: vestibular toxicity.


Instruction: For patients receiving long-term aminoglycosides, serial audiograms may be considered during what?

Output: therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For patients receiving long-term aminoglycosides, serial audiograms may be considered during what?. ### Response: therapy.


Instruction: What is the second antibiotic-related adverse event?

Output: Clostridium difficile infection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the second antibiotic-related adverse event?. ### Response: Clostridium difficile infection.


Instruction: What is not routinely available for monitor-ing vestibular function?

Output: tools

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not routinely available for monitor-ing vestibular function?. ### Response: tools.


Instruction: What is Clostridium difficile infection?

Output: second antibiotic-related adverse event

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Clostridium difficile infection?. ### Response: second antibiotic-related adverse event.


Instruction: How long after the last dose of antibiotic can onset of diarrhea be delayed?

Output: 4 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after the last dose of antibiotic can onset of diarrhea be delayed?. ### Response: 4 weeks.


Instruction: What is the hope that prompt recognition and treatment of this infectious complica-tion will diminish?

Output: the likelihood of severe complications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the hope that prompt recognition and treatment of this infectious complica-tion will diminish?. ### Response: the likelihood of severe complications.


Instruction: What is reasonable before or synchronous with completion of antimicrobial therapy to establish a new baseline for subsequent compari-son?

Output: Echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable before or synchronous with completion of antimicrobial therapy to establish a new baseline for subsequent compari-son?. ### Response: Echocardiography.


Instruction: What should be referred to a program to assist in the cessation of drug use?

Output: IDUs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be referred to a program to assist in the cessation of drug use?. ### Response: IDUs.


Instruction: What should be used for IDUs?

Output: A referral to a program to assist in the cessation of drug use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be used for IDUs?. ### Response: A referral to a program to assist in the cessation of drug use.


Instruction: What should patients be educated about?

Output: relapses can occur

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients be educated about?. ### Response: relapses can occur.


Instruction: What is reasonable in patients deemed likely to require valve replacement?

Output: A thorough dental evaluation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable in patients deemed likely to require valve replacement?. ### Response: A thorough dental evaluation.


Instruction: What is not recommended after the completion of antimicrobial therapy because the likelihood of a positive culture result in what?

Output: Routine blood cultures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended after the completion of antimicrobial therapy because the likelihood of a positive culture result in what?. ### Response: Routine blood cultures.


Instruction: What is the likelihood of a positive culture result in a patient who is otherwise without evidence of active infection low?

Output: Routine blood cultures are not recommended after the completion of antimicrobial therapy because the likelihood of a positive culture result in a patient who is otherwise without evidence of active infection is low

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the likelihood of a positive culture result in a patient who is otherwise without evidence of active infection low?. ### Response: Routine blood cultures are not recommended after the completion of antimicrobial therapy because the likelihood of a positive culture result in a patient who is otherwise without evidence of active infection is low.


Instruction: What should be removed promptly at the end of therapy?

Output: icrobial treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be removed promptly at the end of therapy?. ### Response: icrobial treatment.


Instruction: What may be considered during therapy for patients receiving long-term aminoglycosides?

Output: serial audiograms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered during therapy for patients receiving long-term aminoglycosides?. ### Response: serial audiograms.


Instruction: What should patients be monitored for in the short-term follow-up?

Output: the development of several com-plications, including IE relapse and heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients be monitored for in the short-term follow-up?. ### Response: the development of several com-plications, including IE relapse and heart failure.


Instruction: What is IE relapse and heart failure (Class I; Level of Evidence C)?

Output: com-plications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is IE relapse and heart failure (Class I; Level of Evidence C)?. ### Response: com-plications.


Instruction: What should be done to determine the cause of IE relapse?

Output: patients should be monitored for the development of several com-plications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be done to determine the cause of IE relapse?. ### Response: patients should be monitored for the development of several com-plications.


Instruction: How many sets of blood cultures should be taken?

Output: ≥3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many sets of blood cultures should be taken?. ### Response: ≥3.


Instruction: What should be done to determine the cause of infection signs and symptoms?

Output: a thorough evalua-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be done to determine the cause of infection signs and symptoms?. ### Response: a thorough evalua-tion.


Instruction: Empirical antimicrobial therapy for suspected infection should be avoided unless the patient’s clinical condition warrants it (Class III; Level of Evidence C).

Output: 11

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Empirical antimicrobial therapy for suspected infection should be avoided unless the patient’s clinical condition warrants it (Class III; Level of Evidence C).. ### Response: 11.


Instruction: What should be implemented if TTR 65%?

Output: additional measures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be implemented if TTR 65%?. ### Response: additional measures.


Instruction: What should patients with prior unprovoked bleeding do?

Output: we suggest using apixaban, edoxaban, ordabigatran 110 mg (where available) as alldemonstrate signi ﬁcantly less major bleedingcompared with warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients with prior unprovoked bleeding do?. ### Response: we suggest using apixaban, edoxaban, ordabigatran 110 mg (where available) as alldemonstrate signi ﬁcantly less major bleedingcompared with warfarin.


Instruction: Where is ordabigatran 110 mg available?

Output: where available

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is ordabigatran 110 mg available?. ### Response: where available.


Instruction: What does apixaban, edoxaban and ordabigatran 110 mg do?

Output: less major bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does apixaban, edoxaban and ordabigatran 110 mg do?. ### Response: less major bleeding.


Instruction: What is the only NOACs not associated with an increasedrisk of gastrointestinal bleeding?

Output: apixaban or dabigatran 110 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the only NOACs not associated with an increasedrisk of gastrointestinal bleeding?. ### Response: apixaban or dabigatran 110 mg.


Instruction: What are the only NOACs not associated with an increasedrisk of gastrointestinal bleeding compared with warfarin?

Output: apixaban or dabigatran 110 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the only NOACs not associated with an increasedrisk of gastrointestinal bleeding compared with warfarin?. ### Response: apixaban or dabigatran 110 mg.


Instruction: What is recommended in patients at high risk of ischemic stroke as only agent/dose with superior ef ficacy?

Output: Dabigatran 150 mg twice daily

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended in patients at high risk of ischemic stroke as only agent/dose with superior ef ficacy?. ### Response: Dabigatran 150 mg twice daily.


Instruction: How would bleeding risk need to be assessed and monitored?

Output: Adjusted-Dose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How would bleeding risk need to be assessed and monitored?. ### Response: Adjusted-Dose.


Instruction: What is a class of OACs called?

Output: VKAs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a class of OACs called?. ### Response: VKAs.


Instruction: What are the most commonly used VKAs?

Output: 4-hydroxycoumarins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the most commonly used VKAs?. ### Response: 4-hydroxycoumarins.


Instruction: Phenindione and fluindione are what type of derivative?

Output: 1,3-indandione

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Phenindione and fluindione are what type of derivative?. ### Response: 1,3-indandione.


Instruction: Where is acenocoumarolpopular?

Output: Spain

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is acenocoumarolpopular?. ### Response: Spain.


Instruction: What is the most commonly used drug in randomized clinical trials?

Output: warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most commonly used drug in randomized clinical trials?. ### Response: warfarin.


Instruction: For stroke prevention in patients with AF receiving a VKA, what is the optimal INR target range?

Output: 2.0 to 3.0

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For stroke prevention in patients with AF receiving a VKA, what is the optimal INR target range?. ### Response: 2.0 to 3.0.


Instruction: What is the INR range of 2.0 to 3.0,144?

Output: optimal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the INR range of 2.0 to 3.0,144?. ### Response: optimal.


Instruction: What is a greater risk of thromboembolism/ischemic stroke when INR is 2.0,81,83,85,145-147?

Output: major bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a greater risk of thromboembolism/ischemic stroke when INR is 2.0,81,83,85,145-147?. ### Response: major bleeding.


Instruction: INR levels 3.0 are associated with what type of bleeding?

Output: major bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: INR levels 3.0 are associated with what type of bleeding?. ### Response: major bleeding.


Instruction: What is the most common cause of bleeding when the INR rises above 3.5?

Output: ICH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common cause of bleeding when the INR rises above 3.5?. ### Response: ICH.


Instruction: What did the phase 3 NOAC trials employ an INRtarget of 2.0 to 3.0 among patients receiving warfarin72,73,76,125?

Output: 81-86All

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the phase 3 NOAC trials employ an INRtarget of 2.0 to 3.0 among patients receiving warfarin72,73,76,125?. ### Response: 81-86All.


Instruction: J-ROCKET employed a lower INR target of what for the Japanese population?

Output: 1.6 to 2.6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: J-ROCKET employed a lower INR target of what for the Japanese population?. ### Response: 1.6 to 2.6.