Instruction: e3813.2.1. Resting Imaging to Assess CardiacStructure and Function:Recommendations. e381Fihn et al Stable Ischemic Heart Disease: Full Text e355Downloaded from http://ahajournals.org by what date?

Output: May 1, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: e3813.2.1. Resting Imaging to Assess CardiacStructure and Function:Recommendations. e381Fihn et al Stable Ischemic Heart Disease: Full Text e355Downloaded from http://ahajournals.org by what date?. ### Response: May 1, 2023.


Instruction: What could not exceed the qualitygrade for the overall study?

Output: grade of an individual outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could not exceed the qualitygrade for the overall study?. ### Response: grade of an individual outcome.


Instruction: What was used to grade the quality of an individual outcome?

Output: evidence for each outcome acrossstudies. Following GRADE, the quality of a body of evidencepertaining to a particular outcome of interest was initiallycategorized on the basis of study design

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was used to grade the quality of an individual outcome?. ### Response: evidence for each outcome acrossstudies. Following GRADE, the quality of a body of evidencepertaining to a particular outcome of interest was initiallycategorized on the basis of study design.


Instruction: What was used to grade the quality of the overall evidence and the strength of recommendations?

Output: evidenceproﬁles

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was used to grade the quality of the overall evidence and the strength of recommendations?. ### Response: evidenceproﬁles.


Instruction: Who led the discussion on grading of quality of evidence?

Output: ERT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who led the discussion on grading of quality of evidence?. ### Response: ERT.


Instruction: What discussion was led by the Work Group co-chairs?

Output: discussion regarding the strength of therecommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What discussion was led by the Work Group co-chairs?. ### Response: discussion regarding the strength of therecommendations.


Instruction: Who led the Work Group Co-Chairs?

Output: ERT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who led the Work Group Co-Chairs?. ### Response: ERT.


Instruction: What indicates the extent to which one can be confident that adherence to a recommendation will do more good than harm?

Output: strength of a recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates the extent to which one can be confident that adherence to a recommendation will do more good than harm?. ### Response: strength of a recommendation.


Instruction: The ‘quality of a body of evidence’ refers to what?

Output: RCTs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The ‘quality of a body of evidence’ refers to what?. ### Response: RCTs.


Instruction: How is confidence in an estimate of effect sufficient to support a particular recommendation?

Output: qualityof a body of evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is confidence in an estimate of effect sufficient to support a particular recommendation?. ### Response: qualityof a body of evidence.


Instruction: How is the quality of evidence for each outcome graded acrossstudies?

Output: 445

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the quality of evidence for each outcome graded acrossstudies?. ### Response: 445.


Instruction: What was the initial quality grade of a body of evidencepertaining to a specific outcome of interest?

Output: High

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the initial quality grade of a body of evidencepertaining to a specific outcome of interest?. ### Response: High.


Instruction: What was the initial quality grade for interventions?

Output: High

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the initial quality grade for interventions?. ### Response: High.


Instruction: What did the Work Group decide to use only?

Output: RCTs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Work Group decide to use only?. ### Response: RCTs.


Instruction: Who decided to use only RCTs?

Output: theWork Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who decided to use only RCTs?. ### Response: theWork Group.


Instruction: What was lowered if there were serious limitations to themethodological quality of the aggregate of studies?

Output: The grade for thequality of evidence for each intervention–outcome pair

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was lowered if there were serious limitations to themethodological quality of the aggregate of studies?. ### Response: The grade for thequality of evidence for each intervention–outcome pair.


Instruction: If therewere important inconsistencies in the results across studies, what was the grade for?

Output: lowered

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: If therewere important inconsistencies in the results across studies, what was the grade for?. ### Response: lowered.


Instruction: How many studies or total N o500 were there in a study if there was uncertainty about the directness of evidence?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies or total N o500 were there in a study if there was uncertainty about the directness of evidence?. ### Response: 1.


Instruction: What is the final grade for the quality of the evidence for an intervention- outcome pair?

Output: ‘High’ , ‘Moderate’ , ‘Low’ or‘Very Low

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the final grade for the quality of the evidence for an intervention- outcome pair?. ### Response: ‘High’ , ‘Moderate’ , ‘Low’ or‘Very Low.


Instruction: How was the quality of the overall body of evidence determined?

Output: on the basis ofthe quality grades for all outcomes of interest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the quality of the overall body of evidence determined?. ### Response: on the basis ofthe quality grades for all outcomes of interest.


Instruction: What did KDIGO nomenclature and description for grading recommendations take into account?

Output: quality grades for all outcomes of interest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did KDIGO nomenclature and description for grading recommendations take into account?. ### Response: quality grades for all outcomes of interest.


Instruction: How many people in your situation would want the recommended course of action?

Output: Most

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people in your situation would want the recommended course of action?. ### Response: Most.


Instruction: What should most patients receive?

Output: therecommended course of action

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should most patients receive?. ### Response: therecommended course of action.


Instruction: The recommendation can be evaluated as what?

Output: acandidate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The recommendation can be evaluated as what?. ### Response: acandidate.


Instruction: How many people would want the recommended course ofaction?

Output: Most people in your situation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people would want the recommended course ofaction?. ### Response: Most people in your situation.


Instruction: How many patients need help to make the right choices?

Output: Each

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients need help to make the right choices?. ### Response: Each.


Instruction: What is evolocumab used for in patients with high cardiovascular risk?

Output: Cost-effectiveness of LDL-C lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is evolocumab used for in patients with high cardiovascular risk?. ### Response: Cost-effectiveness of LDL-C lowering.


Instruction: What is the name of the drug used to lower LDL-C?

Output: evolocumab

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used to lower LDL-C?. ### Response: evolocumab.


Instruction: When was the JAMA issue 316?

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the JAMA issue 316?. ### Response: 2016.


Instruction: What is evolocumab used for in patients with high cardiovascular risk in the United States?

Output: Cost-effectiveness of LDL-C lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is evolocumab used for in patients with high cardiovascular risk in the United States?. ### Response: Cost-effectiveness of LDL-C lowering.


Instruction: What is the 2013 ACC/AHA guideline on Choosing interventions that are cost effective?

Output: cost-effectiveness thresholds

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2013 ACC/AHA guideline on Choosing interventions that are cost effective?. ### Response: cost-effectiveness thresholds.


Instruction: What is the name of the 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce ath-erosclerotic cardiovascular risk in adults?

Output: Stone NJ, Robinson JG, Lichtenstein AH, et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce ath-erosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce ath-erosclerotic cardiovascular risk in adults?. ### Response: Stone NJ, Robinson JG, Lichtenstein AH, et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce ath-erosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.


Instruction: What was the title of the report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines?

Output: 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce ath-erosclerotic cardiovascular risk in adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the title of the report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines?. ### Response: 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce ath-erosclerotic cardiovascular risk in adults.


Instruction: How many Thromb Hemost patients were diagnosed in 2010?

Output: 377

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many Thromb Hemost patients were diagnosed in 2010?. ### Response: 377.


Instruction: How many people were diagnosed with thrombus hemost?

Output: 377

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were diagnosed with thrombus hemost?. ### Response: 377.


Instruction: What was the total number of people who had a thrombo hemopoeia in 2010 that were diagnosed?

Output: 183

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the total number of people who had a thrombo hemopoeia in 2010 that were diagnosed?. ### Response: 183.


Instruction: What is heparin-related osteoporosis in rats?

Output: cancellous bone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is heparin-related osteoporosis in rats?. ### Response: cancellous bone.


Instruction: What was a comparative study between unfractioned and a low-molecular-weight?

Output: heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a comparative study between unfractioned and a low-molecular-weight?. ### Response: heparin.


Instruction: Haemostasis. 1990; 20 ( 4 ): 204 - 207

Output: unfractioned heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Haemostasis. 1990; 20 ( 4 ): 204 - 207. ### Response: unfractioned heparin.


Instruction: How many years were there in 1990?

Output: 185

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many years were there in 1990?. ### Response: 185.


Instruction: What was the number of years?

Output: 187

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the number of years?. ### Response: 187.


Instruction: How many months were there?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many months were there?. ### Response: 3.


Instruction: What is the effect of low molecular weight heparin on osteoporosis in rats?

Output: induction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of low molecular weight heparin on osteoporosis in rats?. ### Response: induction.


Instruction: What does heparin do to cancellous bone in rats?

Output: histomor-phometric parameters

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does heparin do to cancellous bone in rats?. ### Response: histomor-phometric parameters.


Instruction: What is the effect of low-molecular-weight hepaline on cancelous bone?

Output: anti-thrombin activities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of low-molecular-weight hepaline on cancelous bone?. ### Response: anti-thrombin activities.


Instruction: How does a histomorphometric comparison of hepatin and heparain compare?

Output: low molecular weight

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does a histomorphometric comparison of hepatin and heparain compare?. ### Response: low molecular weight.


Instruction: What is the effect of heparin on cancellous bone in rats?

Output: histomorphometric comparison

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of heparin on cancellous bone in rats?. ### Response: histomorphometric comparison.


Instruction: Blood. 1997 ; 89 (9): 3263 - 3242.

Output: Blood

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Blood. 1997 ; 89 (9): 3263 - 3242.. ### Response: Blood.


Instruction: Kock HJ, Handschin AE.

Output: 1997 ; 89 (9): 3263 - 3242 .      186 .  Kock

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Kock HJ, Handschin AE.. ### Response: 1997 ; 89 (9): 3263 - 3242 .      186 .  Kock.


Instruction: What is heparin and hep-arins used for?

Output: Osteoblast growth inhibition

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is heparin and hep-arins used for?. ### Response: Osteoblast growth inhibition.


Instruction: What is the name of the drug that inhibits osteoblast growth?

Output: heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug that inhibits osteoblast growth?. ### Response: heparin.


Instruction: In what year did Clin Appl Thromb Hemost publish?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did Clin Appl Thromb Hemost publish?. ### Response: 2002.


Instruction: What does enoxaparin do to histomor-phometric measurements?

Output: Effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does enoxaparin do to histomor-phometric measurements?. ### Response: Effects.


Instruction: What is the name of the drug that has been shown to have a positive effect on histor phometric measurement?

Output: enoxaparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug that has been shown to have a positive effect on histor phometric measurement?. ### Response: enoxaparin.


Instruction: B. Effects of enoxaparin on histomor-phometric parameters of bones in rats?

Output: Effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: B. Effects of enoxaparin on histomor-phometric parameters of bones in rats?. ### Response: Effects.


Instruction: Pol J Pharmacol. 2004; 56 ( 4 ): 451-457.

Output: renal function in patients on

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Pol J Pharmacol. 2004; 56 ( 4 ): 451-457.. ### Response: renal function in patients on.


Instruction: On what drug is enoxaparin used?

Output: renal impairment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On what drug is enoxaparin used?. ### Response: renal impairment.


Instruction: What is the name of the drug that is used to treat cancer?

Output: dalteparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug that is used to treat cancer?. ### Response: dalteparin.


Instruction: When was the last issue of J Clin Pharmacol?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last issue of J Clin Pharmacol?. ### Response: 2003.


Instruction: What is the prophylactic dose of enoxaparin once daily over 4 days in patients with renal impairment?

Output: Pharmacokinetics and phar-macodynamics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the prophylactic dose of enoxaparin once daily over 4 days in patients with renal impairment?. ### Response: Pharmacokinetics and phar-macodynamics.


Instruction: What are the pharmacokinetics and phar-macodynamics of?

Output: the prophylactic dose of enoxaparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the pharmacokinetics and phar-macodynamics of?. ### Response: the prophylactic dose of enoxaparin.


Instruction: In patients with renal impairment, what does Thromb Res do?

Output: bioaccumulation of dalteparin at a therapeutic dose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with renal impairment, what does Thromb Res do?. ### Response: bioaccumulation of dalteparin at a therapeutic dose.


Instruction: What is Schmid P, Brodmann D, Odermatt Y?

Output: D

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Schmid P, Brodmann D, Odermatt Y?. ### Response: D.


Instruction: D, Odermatt Y, Fischer AG, Wuillemin WA, and Fischer AG?

Output: Brodmann

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: D, Odermatt Y, Fischer AG, Wuillemin WA, and Fischer AG?. ### Response: Brodmann.


Instruction: What is dalteparin at a therapeutic dose in patients with?

Output: renal insufﬁ  ciency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is dalteparin at a therapeutic dose in patients with?. ### Response: renal insufﬁ  ciency.


Instruction: How many years was the J Thromb Haemost in 2009?

Output: 1629 - 1632 .      158

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many years was the J Thromb Haemost in 2009?. ### Response: 1629 - 1632 .      158.


Instruction: What is the name of the study that examined the relationship between aging and venous disease?

Output: Thromb Haemost

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined the relationship between aging and venous disease?. ### Response: Thromb Haemost.


Instruction: How many months were there between 1629 and 1632?

Output: 158

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many months were there between 1629 and 1632?. ### Response: 158.


Instruction: Aging and venous thromboembolism infl uence the pharmacody-namics of the anti-factor Xa and anti-thrombin activities of a low molecular weight heparin?

Output: inﬂ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Aging and venous thromboembolism infl uence the pharmacody-namics of the anti-factor Xa and anti-thrombin activities of a low molecular weight heparin?. ### Response: inﬂ.


Instruction: What is tinzaparin known as?

Output: Innohep

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is tinzaparin known as?. ### Response: Innohep.


Instruction: How many times a day are elderly patients treated?

Output: once

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many times a day are elderly patients treated?. ### Response: once.


Instruction: What is Innohep?

Output: tinzaparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Innohep?. ### Response: tinzaparin.


Instruction: What is tinzaparin also known as?

Output: Innohep

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is tinzaparin also known as?. ### Response: Innohep.


Instruction: How much anti-Xa IU/kg is given daily for 10 days?

Output: 175

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much anti-Xa IU/kg is given daily for 10 days?. ### Response: 175.


Instruction: What is the name of the drug used to treat Xa and IIa?

Output: tinzaparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used to treat Xa and IIa?. ### Response: tinzaparin.


Instruction: In 2000, how many Thromb Haemost were used?

Output: 800 - 804

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In 2000, how many Thromb Haemost were used?. ### Response: 800 - 804.


Instruction: What is the name of the meta-analysis of low-molecular-weight heparin and bleeding in patients with severe renal insuffi ciency?

Output: Ann Intern Med

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis of low-molecular-weight heparin and bleeding in patients with severe renal insuffi ciency?. ### Response: Ann Intern Med.


Instruction: What year did Ann Intern Med publish 144 ( 9 ): 673 - 684?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Ann Intern Med publish 144 ( 9 ): 673 - 684?. ### Response: 2006.


Instruction: Spinler SA, Inverso SM, Cohen M, Goodman SG, and Cohen M are among the 161 authors of what journal?

Output: Ann Intern Med

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Spinler SA, Inverso SM, Cohen M, Goodman SG, and Cohen M are among the 161 authors of what journal?. ### Response: Ann Intern Med.


Instruction: Cohen M, Goodman SG, Stringer KA, Antman EM and TIMI 11B Investigators?

Output: ESSENCE and TIMI 11B Investi gators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cohen M, Goodman SG, Stringer KA, Antman EM and TIMI 11B Investigators?. ### Response: ESSENCE and TIMI 11B Investi gators.


Instruction: Safety and efficacy of unfractionated heparin?

Output: Osteoblast growth inhibition

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Safety and efficacy of unfractionated heparin?. ### Response: Osteoblast growth inhibition.


Instruction: What is the AHA/ACC NSTE-ACS Guideline e425GP IIb/IIIa Inhibitors?

Output: Eptifibatide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the AHA/ACC NSTE-ACS Guideline e425GP IIb/IIIa Inhibitors?. ### Response: Eptifibatide.


Instruction: What does Eptifibatide weight/renally dose?

Output: ↑Bleeding risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Eptifibatide weight/renally dose?. ### Response: ↑Bleeding risk.


Instruction: How much bleeding risk does Tirofiban have?

Output: high

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much bleeding risk does Tirofiban have?. ### Response: high.


Instruction: What is the weight-based dose of INF?

Output: 180 mcg/kg loading dose + 2 mcg/kg/min

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the weight-based dose of INF?. ### Response: 180 mcg/kg loading dose + 2 mcg/kg/min.


Instruction: How much clearance does INF have?

Output: 20%–40%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much clearance does INF have?. ### Response: 20%–40%.


Instruction: What is INF effective with?

Output: ↓bleedingWarfarin ↑Sensitivity; ↓20%–40% clearance; protein binding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is INF effective with?. ### Response: ↓bleedingWarfarin ↑Sensitivity; ↓20%–40% clearance; protein binding.


Instruction: What does vitamin K-dependent clotting factors inhibit at same plasma levels with age?

Output: Bleeding risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does vitamin K-dependent clotting factors inhibit at same plasma levels with age?. ### Response: Bleeding risk.


Instruction: What is bleeding risk at lower INR?

Output: higher INR/dose with ↑age ↑risk GI bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is bleeding risk at lower INR?. ### Response: higher INR/dose with ↑age ↑risk GI bleeding.


Instruction: What does ASA potentiate?

Output: effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ASA potentiate?. ### Response: effect.


Instruction: What is a contraindicated if CrCl 15 mL/minIf pt taking when admitted, stop–consider delaying angiogram/PCI until effect wanes?

Output: avoiding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a contraindicated if CrCl 15 mL/minIf pt taking when admitted, stop–consider delaying angiogram/PCI until effect wanes?. ### Response: avoiding.


Instruction: If bleeding 2 post-ACS, consider what?

Output: BMS and radial access

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: If bleeding 2 post-ACS, consider what?. ### Response: BMS and radial access.


Instruction: What is the thrombotic risk following discontinuation of GP IIb/IIIa inhibitor?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the thrombotic risk following discontinuation of GP IIb/IIIa inhibitor?. ### Response: ↑.


Instruction: What percentage cleared renally of Rivaroxaban?

Output: 35%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage cleared renally of Rivaroxaban?. ### Response: 35%.


Instruction: How much CrCl >50 mL/min: 20 mg QD?

Output: 15–30 mL/min

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much CrCl >50 mL/min: 20 mg QD?. ### Response: 15–30 mL/min.


Instruction: What is not reversible CrCl 15-30 mL/min if bleeding risk?

Output: 15 mg QD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not reversible CrCl 15-30 mL/min if bleeding risk?. ### Response: 15 mg QD.


Instruction: What is 80% cleared renally with Dabigatran?

Output: Dabigatran

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is 80% cleared renally with Dabigatran?. ### Response: Dabigatran.


Instruction: What is the dose of CrCl >50 mL/min?

Output: 150 mg BID

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the dose of CrCl >50 mL/min?. ### Response: 150 mg BID.


Instruction: How long does it take for the effect to wane?

Output: longest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take for the effect to wane?. ### Response: longest.


Instruction: Apixaban Hepatically cleared (minor CYP3A4) what is the risk of bleeding?

Output: dyspepsia, GI bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Apixaban Hepatically cleared (minor CYP3A4) what is the risk of bleeding?. ### Response: dyspepsia, GI bleeding.


Instruction: What risk is not reversible?

Output: Bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What risk is not reversible?. ### Response: Bleeding.


Instruction: What should be calculated for all older pts because SCr level does not accurately reflect?

Output: CrCl

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be calculated for all older pts because SCr level does not accurately reflect?. ### Response: CrCl.


Instruction: Why does SCr level not accurately reflect renal dysfunction?

Output: Risk abnormal liver  function tests*CrCl should be calculated for all older pts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why does SCr level not accurately reflect renal dysfunction?. ### Response: Risk abnormal liver  function tests*CrCl should be calculated for all older pts.


Instruction: CrCl decreases with age 0.7 mL/min/y?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: CrCl decreases with age 0.7 mL/min/y?. ### Response: *.


Instruction: AC indicates anticoagulants; ACE, what?

Output: angiotensin-converting-enzyme

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: AC indicates anticoagulants; ACE, what?. ### Response: angiotensin-converting-enzyme.


Instruction: ADR, acute coronary syndromes; what is ADR?

Output: adverse drug reactions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ADR, acute coronary syndromes; what is ADR?. ### Response: adverse drug reactions.


Instruction: What is ACS?

Output: acute coronary syndromes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ACS?. ### Response: acute coronary syndromes.


Instruction: What is ADR?

Output: adverse drug reactions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ADR?. ### Response: adverse drug reactions.


Instruction: AKI is acute kidney injury.

Output: age ≥80 y/weight ≤60 kg/SCr ≥1.5 mg/ dL: SCr <1.5: 5 mg BID↑Risk abnormal liver  function tests*CrCl should be calculated for all older pts because SCr level does not accurately reflect renal dysfunction: CrCl decreases with age 0.7 mL/min/y.†

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: AKI is acute kidney injury.. ### Response: age ≥80 y/weight ≤60 kg/SCr ≥1.5 mg/ dL: SCr <1.5: 5 mg BID↑Risk abnormal liver  function tests*CrCl should be calculated for all older pts because SCr level does not accurately reflect renal dysfunction: CrCl decreases with age 0.7 mL/min/y.†.


Instruction: What is the risk for IS and hemorrhagic stroke in women?

Output: low

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk for IS and hemorrhagic stroke in women?. ### Response: low.


Instruction: What is adjusted OR for preeclampsia?

Output: 7.7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is adjusted OR for preeclampsia?. ### Response: 7.7.


Instruction: What is the absolute risk of stroke for women?

Output: low

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the absolute risk of stroke for women?. ### Response: low.


Instruction: What do the majority of studies with both men and women support?

Output: predominantly female issue

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do the majority of studies with both men and women support?. ### Response: predominantly female issue.


Instruction: What are the largest cohorts that have been studied?

Output: women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the largest cohorts that have been studied?. ### Response: women.


Instruction: What are there not enough data to recommend?

Output: specific approaches to treat migraine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are there not enough data to recommend?. ### Response: specific approaches to treat migraine.


Instruction: What is the risk of treatment with trip-tans in women with migraine with aura?

Output: stroke risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of treatment with trip-tans in women with migraine with aura?. ### Response: stroke risk.


Instruction: What are the guidelines from the American Academy of Neurology specifically stated in?

Output: Migraine treatment with triptans

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the guidelines from the American Academy of Neurology specifically stated in?. ### Response: Migraine treatment with triptans.


Instruction: What is another word for oral contraceptives?

Output: OCs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another word for oral contraceptives?. ### Response: OCs.


Instruction: What is the risk of stroke among those who smoke cigarettes?

Output: higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of stroke among those who smoke cigarettes?. ### Response: higher.


Instruction: What may be reasonable to include in a woman-specific risk profile?

Output: Oral Contraceptives

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be reasonable to include in a woman-specific risk profile?. ### Response: Oral Contraceptives.


Instruction: What are the general rec-ommendations for men and women with migraine with aura and stroke?

Output: as stated in the primary prevention guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the general rec-ommendations for men and women with migraine with aura and stroke?. ### Response: as stated in the primary prevention guideline.


Instruction: What is an association between migraine frequency and stroke risk?

Output: aura and smoking

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an association between migraine frequency and stroke risk?. ### Response: aura and smoking.


Instruction: What is the class of evidence that migraine treatment reduces the risk of first stroke?

Output: Class IIb

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the class of evidence that migraine treatment reduces the risk of first stroke?. ### Response: Class IIb.


Instruction: Why are migraine headaches more common in women?

Output: increased stroke risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why are migraine headaches more common in women?. ### Response: increased stroke risk.


Instruction: What is the class of smoking cessation recommended for migraine headaches with aura?

Output: Class IIa

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the class of smoking cessation recommended for migraine headaches with aura?. ### Response: Class IIa.


Instruction: By 2030, what percentage of Americans will be obese?

Output: 86%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: By 2030, what percentage of Americans will be obese?. ### Response: 86%.


Instruction: In 2030, what percentage of Americans will be overweight or obese?

Output: 86%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In 2030, what percentage of Americans will be overweight or obese?. ### Response: 86%.


Instruction: Obesity affects a disproportionate number of what?

Output: women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Obesity affects a disproportionate number of what?. ### Response: women.


Instruction: What was the age-adjusted prevalence of obesity in the United States in 2007 to 2008?

Output: 35.2%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the age-adjusted prevalence of obesity in the United States in 2007 to 2008?. ### Response: 35.2%.


Instruction: What percentage of men are obese?

Output: 49.6%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of men are obese?. ### Response: 49.6%.


Instruction: What race has the highest prevalence of obesity?

Output: Hispanic black

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What race has the highest prevalence of obesity?. ### Response: Hispanic black.


Instruction: Who coined the term android obe-sity?

Output: Vague295

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who coined the term android obe-sity?. ### Response: Vague295.


Instruction: Where is the body fat concentrated?

Output: abdominal area

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the body fat concentrated?. ### Response: abdominal area.


Instruction: What term was introduced to describe the low-risk lower-body adiposity?

Output: gynoid obesity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What term was introduced to describe the low-risk lower-body adiposity?. ### Response: gynoid obesity.


Instruction: Abdominal obesity is defined as waist circumference >88 cm in women and >102 cm in men?

Output: far more prevalent in women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Abdominal obesity is defined as waist circumference >88 cm in women and >102 cm in men?. ### Response: far more prevalent in women.


Instruction: What is waist circumference defined as in women and men?

Output: Abdominal obesity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is waist circumference defined as in women and men?. ### Response: Abdominal obesity.


Instruction: In men and women, what is the definition?

Output: Abdominal obesity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In men and women, what is the definition?. ### Response: Abdominal obesity.


Instruction: What are the definitions?

Output: waist circumference >88 cm in women and >102 cm in men

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the definitions?. ### Response: waist circumference >88 cm in women and >102 cm in men.


Instruction: Which is more prevalent in women?

Output: Abdominal obesity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which is more prevalent in women?. ### Response: Abdominal obesity.


Instruction: What is the effect of chronization therapy on left ventricular size and function in chronic heart failure?

Output: 1985–90

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of chronization therapy on left ventricular size and function in chronic heart failure?. ### Response: 1985–90.


Instruction: What is a therapeutic option in patients with moderate-severe functional mitral regurgitation and high operative risk?

Output: Cardiac resynchroniza-tion therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a therapeutic option in patients with moderate-severe functional mitral regurgitation and high operative risk?. ### Response: Cardiac resynchroniza-tion therapy.


Instruction: What is operative risk?

Output: high

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is operative risk?. ### Response: high.


Instruction: What is angiotensin receptor neprilysin inhibi-tor for?

Output: functional mitral regurgitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is angiotensin receptor neprilysin inhibi-tor for?. ### Response: functional mitral regurgitation.


Instruction: What is the name of the organization that failed to publish a report?

Output: American College of Downloaded from http://ahajournals.org

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that failed to publish a report?. ### Response: American College of Downloaded from http://ahajournals.org.


Instruction: When was the failure of the American College of Arts and Sciences published?

Output: April 27, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the failure of the American College of Arts and Sciences published?. ### Response: April 27, 2023.


Instruction: Where did the failure report come from?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where did the failure report come from?. ### Response: http://ahajournals.org.


Instruction: What is the name of the Atherosclerosis Risk in Communities cohort?

Output: ARIC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Atherosclerosis Risk in Communities cohort?. ### Response: ARIC.


Instruction: How long did the ARIC cohort follow up?

Output: 9-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the ARIC cohort follow up?. ### Response: 9-year.


Instruction: What was the outcome of the 9-year follow-up?

Output: Stroke incidence and survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome of the 9-year follow-up?. ### Response: Stroke incidence and survival.


Instruction: What is the Strong Heart Study?

Output: Incidence and risk factors for stroke in American Indians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Strong Heart Study?. ### Response: Incidence and risk factors for stroke in American Indians.


Instruction: Incidence and risk factors for stroke in American Indians?

Output: Best L, Lee ET

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Incidence and risk factors for stroke in American Indians?. ### Response: Best L, Lee ET.


Instruction: Circulation. 2008;118:1577–1584.

Output: Best L, Lee ET

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation. 2008;118:1577–1584.. ### Response: Best L, Lee ET.


Instruction: What is a critical review of the risk factors for stroke in blacks?

Output: Am J Epidemiol. 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a critical review of the risk factors for stroke in blacks?. ### Response: Am J Epidemiol. 1999.


Instruction: What is the National Health and Nutrition Examination Survey Epidemiologic Follow-up Study?

Output: Determinants of black-white differences in the risk of cerebral infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the National Health and Nutrition Examination Survey Epidemiologic Follow-up Study?. ### Response: Determinants of black-white differences in the risk of cerebral infarction.


Instruction: What is a critical review of risk factors for stroke in blacks?

Output: Am J Epidemiol. 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a critical review of risk factors for stroke in blacks?. ### Response: Am J Epidemiol. 1999.


Instruction: What is the contribution of hypertension and diabetes mellitus to stroke incidence in a national sample?

Output: Black-white differences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the contribution of hypertension and diabetes mellitus to stroke incidence in a national sample?. ### Response: Black-white differences.


Instruction: What is myocardial infarction?

Output: ventriculararrhythmia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is myocardial infarction?. ### Response: ventriculararrhythmia.


Instruction: What is VA?

Output: ventriculararrhythmia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is VA?. ### Response: ventriculararrhythmia.


Instruction: When was e360 circulated?

Output: December 18/25, 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was e360 circulated?. ### Response: December 18/25, 2012.


Instruction: How many patients underwent an analysis of creases in volume and significant decreases in mechanical valve use?

Output: 41,227

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients underwent an analysis of creases in volume and significant decreases in mechanical valve use?. ### Response: 41,227.


Instruction: Who conducted the analysis of 41,227 patients over 5 years from the Society for Cardiotho-racic Surgery in Great Britain and Ireland National database?

Output: Society of Thoracic Surgeons

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who conducted the analysis of 41,227 patients over 5 years from the Society for Cardiotho-racic Surgery in Great Britain and Ireland National database?. ### Response: Society of Thoracic Surgeons.


Instruction: What is the age range for aortic valve replacement?

Output: 55 to 70 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the age range for aortic valve replacement?. ### Response: 55 to 70 years.


Instruction: What was the age of the patients enrolled in the prospective randomized evaluation of mechanical versus biological valves?

Output: 55 to 70 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the age of the patients enrolled in the prospective randomized evaluation of mechanical versus biological valves?. ### Response: 55 to 70 years.


Instruction: When was the J Am Coll Cardiol.54:1862-8?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol.54:1862-8?. ### Response: 2009.


Instruction: How long did the Carpentier-Edwards aortic pericardial bioprosthesis last?

Output: 17 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the Carpentier-Edwards aortic pericardial bioprosthesis last?. ### Response: 17 years.


Instruction: What is the Society of Thoracic Surgeons Adult Cardiac Surgery National Database?

Output: Long-term safety and effective-ness of mechanical versus biologic aortic valve prostheses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Society of Thoracic Surgeons Adult Cardiac Surgery National Database?. ### Response: Long-term safety and effective-ness of mechanical versus biologic aortic valve prostheses.


Instruction: How many years of the Carpentier-Edwards aortic pericardial bioprosthesis have been used?

Output: 17

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many years of the Carpentier-Edwards aortic pericardial bioprosthesis have been used?. ### Response: 17.


Instruction: What is the name of the bioprothesis used to replace the Aortic valve?

Output: Carpentier-Edwards Perimount pericardial bioprosthesis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the bioprothesis used to replace the Aortic valve?. ### Response: Carpentier-Edwards Perimount pericardial bioprosthesis.


Instruction: How many patients have had the Biocor porcine bioprosthesis for 20 years?

Output: 1712

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients have had the Biocor porcine bioprosthesis for 20 years?. ### Response: 1712.


Instruction: How many years of experience have patients had with Biocor?

Output: 1712

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many years of experience have patients had with Biocor?. ### Response: 1712.


Instruction: What was the result of the Han-cock II?

Output: Twenty-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the result of the Han-cock II?. ### Response: Twenty-year.


Instruction: When was the J Thorac Cardiovasc Surg published?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Thorac Cardiovasc Surg published?. ### Response: 2002.


Instruction: What is the name of the JACC state-of-the-art review of the Ross procedure in adults for car -diologists and cardiac surgeons?

Output: Adult Cardiac Surgery National Database

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the JACC state-of-the-art review of the Ross procedure in adults for car -diologists and cardiac surgeons?. ### Response: Adult Cardiac Surgery National Database.


Instruction: What type of therapy does Cannegieter SC, Rosendaal FR, Brit E use?

Output: Antithrombotic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy does Cannegieter SC, Rosendaal FR, Brit E use?. ### Response: Antithrombotic.


Instruction: What are the complications of mechanical heart valve prostheses?

Output: Late hemodynamic and clinical out-comes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the complications of mechanical heart valve prostheses?. ### Response: Late hemodynamic and clinical out-comes.


Instruction: What is the cause of bleeding complications?

Output: Thromboembolic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cause of bleeding complications?. ### Response: Thromboembolic.


Instruction: How is antithrombotic management of patients treated?

Output: LOWERing the INtensity of oral anticoaGulant Therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is antithrombotic management of patients treated?. ### Response: LOWERing the INtensity of oral anticoaGulant Therapy.


Instruction: Who is the author of the study?

Output: Zhao Y

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of the study?. ### Response: Zhao Y.


Instruction: What is the name of the study that compares dabig-atran etexilate with warfarin in mechanical heart valve patients?

Output: the Randomized, phase II study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that compares dabig-atran etexilate with warfarin in mechanical heart valve patients?. ### Response: the Randomized, phase II study.


Instruction: What type of valves are used in prosthetic heart valves?

Output: biologic aortic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of valves are used in prosthetic heart valves?. ### Response: biologic aortic.


Instruction: When did the Lancet 374:565-76 publish?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Lancet 374:565-76 publish?. ### Response: 2009.


Instruction: What is the name of the Randomized, phase II study to Evaluate the sAfety and pharmacokinetics of oraL dabIGatran etexilate in patients after heart valve replacemeNt?

Output: RE-ALIGN

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Randomized, phase II study to Evaluate the sAfety and pharmacokinetics of oraL dabIGatran etexilate in patients after heart valve replacemeNt?. ### Response: RE-ALIGN.


Instruction: What is RE-ALIGN?

Output: Randomized, phase II study to Evaluate the sAfety and pharmacokinetics of oraL dabIGatran etexilate in patients after heart valve replacemeNt

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is RE-ALIGN?. ### Response: Randomized, phase II study to Evaluate the sAfety and pharmacokinetics of oraL dabIGatran etexilate in patients after heart valve replacemeNt.


Instruction: When was the Am Heart J.163:931–7.e1 published?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Am Heart J.163:931–7.e1 published?. ### Response: 2012.


Instruction: What is warfarin used for in patients with mechanical heart valves?

Output: Dabigatran

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is warfarin used for in patients with mechanical heart valves?. ### Response: Dabigatran.


Instruction: What is the N Engl J Med 2013:369:1206–14?

Output: sus warfarin in patients with mechanical heart valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the N Engl J Med 2013:369:1206–14?. ### Response: sus warfarin in patients with mechanical heart valves.


Instruction: In what year was the “LOWERING-IT” trial conducted?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was the “LOWERING-IT” trial conducted?. ### Response: 2010.


Instruction: What did the “LOWERING-IT” Trial do?

Output: LOWERing the INtensity of oral anticoaGulant Therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the “LOWERING-IT” Trial do?. ### Response: LOWERing the INtensity of oral anticoaGulant Therapy.


Instruction: What was the name of the trial?

Output: LOWERING-IT” Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the trial?. ### Response: LOWERING-IT” Trial.


Instruction: When was the Am Heart J.160:171–8?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Am Heart J.160:171–8?. ### Response: 2010.


Instruction: What type of PVCs were associated with increased risk of death and nonfatal cardiovascular adverse outcomes?

Output: multifocal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of PVCs were associated with increased risk of death and nonfatal cardiovascular adverse outcomes?. ### Response: multifocal.


Instruction: What was independently associated with nonsustained ventricular tachycardia?

Output: increased risk of death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was independently associated with nonsustained ventricular tachycardia?. ### Response: increased risk of death.


Instruction: What was independently associated with increased risk of death and other cardio-vascular adverse outcomes?

Output: nonsustained ventricular tachycardia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was independently associated with increased risk of death and other cardio-vascular adverse outcomes?. ### Response: nonsustained ventricular tachycardia.


Instruction: What was also seen in the ARIC population?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was also seen in the ARIC population?. ### Response: stroke.


Instruction: What is a risk factor for adverse cardiovascular outcomes?

Output: the detection of PVCs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for adverse cardiovascular outcomes?. ### Response: the detection of PVCs.


Instruction: What are patients evaluated to ensure they do not have underlying conditions?

Output: PVCs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients evaluated to ensure they do not have underlying conditions?. ### Response: PVCs.


Instruction: What are conditions that warrant further treatment to reduce risk?

Output: ischemic heart disease, left ventricular [LV] dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are conditions that warrant further treatment to reduce risk?. ### Response: ischemic heart disease, left ventricular [LV] dysfunction.


Instruction: What are PVC and NSVT associated with in patients with cardiovascular disease?

Output: adverse outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are PVC and NSVT associated with in patients with cardiovascular disease?. ### Response: adverse outcomes.


Instruction: Who increased the risk of death de-spite suppression of VA?

Output: treat-ment of patients with post-myocardial infarction (MI) who took antiarrhythmic medications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who increased the risk of death de-spite suppression of VA?. ### Response: treat-ment of patients with post-myocardial infarction (MI) who took antiarrhythmic medications.


Instruction: Treatment of PVCs with antiarrhythmic medications has not been shown to reduce mortality?

Output: S2.2.2-14,S2.2.2-15

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Treatment of PVCs with antiarrhythmic medications has not been shown to reduce mortality?. ### Response: S2.2.2-14,S2.2.2-15.


Instruction: What is a class I sodium channel-blocking med-cation?

Output: quinidine, flecainide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a class I sodium channel-blocking med-cation?. ### Response: quinidine, flecainide.


Instruction: What increases the risk of death in patients with a reduced LVEF class I?

Output: sodium channel–blocking medications and d-sotalol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What increases the risk of death in patients with a reduced LVEF class I?. ### Response: sodium channel–blocking medications and d-sotalol.


Instruction: What is the 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive SummaryCirculation. 2019;140:e563–e595. DOI: 10.1161/CIR.0000000000000677 September 10, 2019 e569CLINICAL STATEMENTS AND GUIDELINES2.2

Output: Arnett et al 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive SummaryCirculation. 2019;140:e563–e595. DOI: 10.1161/CIR.0000000000000677 September 10, 2019 e569CLINICAL STATEMENTS  AND GUIDELINES2.2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive SummaryCirculation. 2019;140:e563–e595. DOI: 10.1161/CIR.0000000000000677 September 10, 2019 e569CLINICAL STATEMENTS AND GUIDELINES2.2. ### Response: Arnett et al 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive SummaryCirculation. 2019;140:e563–e595. DOI: 10.1161/CIR.0000000000000677 September 10, 2019 e569CLINICAL STATEMENTS  AND GUIDELINES2.2.


Instruction: What should clinicians use to assess traditional cardiovascular risk factors and calculate 10-year risk of ASCVD?

Output: pooled cohort equations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should clinicians use to assess traditional cardiovascular risk factors and calculate 10-year risk of ASCVD?. ### Response: pooled cohort equations.


Instruction: What are pooled cohort equations?

Output: PCE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are pooled cohort equations?. ### Response: PCE.


Instruction: How often is it reasonable for adults 20 to 39 years of age to assess traditional ASCVD risk factors?

Output: at least every 4 to  6 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often is it reasonable for adults 20 to 39 years of age to assess traditional ASCVD risk factors?. ### Response: at least every 4 to  6 years.


Instruction: What is the borderline risk range?

Output: 5% to <7.5%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the borderline risk range?. ### Response: 5% to <7.5%).


Instruction: What is a reasonable use of additional risk-enhancing factors to guide decisions about preventive interventions?

Output: revise the 10-year ASCVD risk estimate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a reasonable use of additional risk-enhancing factors to guide decisions about preventive interventions?. ### Response: revise the 10-year ASCVD risk estimate.


Instruction: In adults at intermediate risk (7.5% to 20% 10-year ASCVD risk) or selected adults at what risk?

Output: borderline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In adults at intermediate risk (7.5% to 20% 10-year ASCVD risk) or selected adults at what risk?. ### Response: borderline.


Instruction: What is an example of a preventive intervention?

Output: statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a preventive intervention?. ### Response: statin therapy.


Instruction: What percentage of ASCVD risk is considered to be borderline?

Output: 5% to <7.5%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of ASCVD risk is considered to be borderline?. ### Response: 5% to <7.5%).


Instruction: What is a reasonable measure to guide clinician-patient risk discussion?

Output: coronary artery calcium score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a reasonable measure to guide clinician-patient risk discussion?. ### Response: coronary artery calcium score.


Instruction: For adults 20 to 39 years of age and for adults between 20 and 39?

Output: For adults 20 to 39 years of age and for those 40 to 59 years of age who have <7.5% 10-year ASCVD risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For adults 20 to 39 years of age and for adults between 20 and 39?. ### Response: For adults 20 to 39 years of age and for those 40 to 59 years of age who have <7.5% 10-year ASCVD risk.


Instruction: What percentage of 10-year ASCVD risk are adults 20 to 39 years of age?

Output: <7.5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of 10-year ASCVD risk are adults 20 to 39 years of age?. ### Response: <7.5%.


Instruction: What is the 10-year risk for adults 40 to 59 years old?

Output: <7.5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 10-year risk for adults 40 to 59 years old?. ### Response: <7.5%.


Instruction: How long is the risk for 30-years as compared to 10-years?

Output: <7.5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the risk for 30-years as compared to 10-years?. ### Response: <7.5%.


Instruction: What is the median risk of ASCVD?

Output: <7.5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the median risk of ASCVD?. ### Response: <7.5%.


Instruction: What are some factors that can be used to revise the 10-year risk estimate?

Output: pooled cohort equations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some factors that can be used to revise the 10-year risk estimate?. ### Response: pooled cohort equations.


Instruction: Who may have a fam-ily history of premature ascvd?

Output: males

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who may have a fam-ily history of premature ascvd?. ### Response: males.


Instruction: What type of rheumatoid arthritis is referred to as?

Output: chronic inflam-matory disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of rheumatoid arthritis is referred to as?. ### Response: chronic inflam-matory disease.


Instruction: What is a he-tory of preeclampsia called?

Output: S2.2-13

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a he-tory of preeclampsia called?. ### Response: S2.2-13.


Instruction: Which type of kidney disease is called a chronic kidney disease?

Output: inflam-matory disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which type of kidney disease is called a chronic kidney disease?. ### Response: inflam-matory disease.


Instruction: What type of atherosclerosis is more likely to be reclassified upward or downward?

Output: coronary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of atherosclerosis is more likely to be reclassified upward or downward?. ### Response: coronary.


Instruction: What are risk-enhancing factors for Clinician-Patient Risk Discussion?

Output: Family history of premature ASCVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are risk-enhancing factors for Clinician-Patient Risk Discussion?. ### Response: Family history of premature ASCVD.


Instruction: How old are males at risk of premature ASCVD?

Output: <55 y

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old are males at risk of premature ASCVD?. ### Response: <55 y.


Instruction: What is the average age of females?

Output: <65 y

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the average age of females?. ### Response: <65 y.


Instruction: What percentage of CABG patients had previous cerebrovascular symptoms?

Output: 5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of CABG patients had previous cerebrovascular symptoms?. ### Response: 5%.


Instruction: What is the peri-CABG stroke rate in patients with bilateral carotid artery stenoses?

Output: 5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the peri-CABG stroke rate in patients with bilateral carotid artery stenoses?. ### Response: 5%.


Instruction: What is a strategy to reduce the postoperative stroke risk in CABG patients with known carotid arterydisease?

Output: combined carotid and coronaryrevascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a strategy to reduce the postoperative stroke risk in CABG patients with known carotid arterydisease?. ### Response: combined carotid and coronaryrevascularization.


Instruction: What is the lack of clarity about the optimal approach to revascularization?

Output: several factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the lack of clarity about the optimal approach to revascularization?. ### Response: several factors.


Instruction: What is the etiology of postoperative stroke often multifactorial?

Output: ascending aortic calcifications with resultantatherothrombotic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the etiology of postoperative stroke often multifactorial?. ### Response: ascending aortic calcifications with resultantatherothrombotic.


Instruction: What causes the lack of clarity about the optimal approach to the management of stroke patients?

Output: several factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes the lack of clarity about the optimal approach to the management of stroke patients?. ### Response: several factors.


Instruction: What are some risk factors for stroke coexist in CABG patients?

Output: •The rates for postoperative stroke and death for carotidendarterectomy and for CABG, independent of or inconjunction with one another

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some risk factors for stroke coexist in CABG patients?. ### Response: •The rates for postoperative stroke and death for carotidendarterectomy and for CABG, independent of or inconjunction with one another.


Instruction: What are the rates for postoperative stroke and death for carotidendarterectomy and for CABG?

Output: vary considerably indifferent patient populations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the rates for postoperative stroke and death for carotidendarterectomy and for CABG?. ### Response: vary considerably indifferent patient populations.


Instruction: How much of all post-CABG strokes occur afteruneventful recovery from CABG?

Output: More than half

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of all post-CABG strokes occur afteruneventful recovery from CABG?. ### Response: More than half.


Instruction: What are some of the causes of postoperative strokes?

Output: ascending aortic calcifications with resultantatherothrombotic embolization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the causes of postoperative strokes?. ### Response: ascending aortic calcifications with resultantatherothrombotic embolization.


Instruction: What makes the decision-making process for the proce-dures even more complex?

Output: Advances in technologies for carotid and coronary revas-cularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What makes the decision-making process for the proce-dures even more complex?. ### Response: Advances in technologies for carotid and coronary revas-cularization.


Instruction: Inpatients with significant carotid artery disease or in anatomic distribution not consistent with a knowncarotidic arterial stenosis have a substantial proportion of post-CABG strokes.

Output: staged

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Inpatients with significant carotid artery disease or in anatomic distribution not consistent with a knowncarotidic arterial stenosis have a substantial proportion of post-CABG strokes.. ### Response: staged.


Instruction: What type of artery stenting provides an alterna-tive to endarterectomy?

Output: carotid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of artery stenting provides an alterna-tive to endarterectomy?. ### Response: carotid.


Instruction: What may reduce the risk of postop-erative stroke?

Output: combined carotid and coronaryrevascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may reduce the risk of postop-erative stroke?. ### Response: combined carotid and coronaryrevascularization.


Instruction: What is the final impact of carotid artery stenting on postoperative stroke rates?

Output: death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the final impact of carotid artery stenting on postoperative stroke rates?. ### Response: death.


Instruction: What is reserved for CABG patients in whom a contraindication toopen endarterectomy exists?

Output: carotid artery stenting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reserved for CABG patients in whom a contraindication toopen endarterectomy exists?. ### Response: carotid artery stenting.


Instruction: What is the name of the European Network for Non-invasive Investigation of Large Arteries?

Output: Laurent S, Cockcroft J, Van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D, Pannier B, Vlachopoulos C, Wilkinson I, Struijker-Boudier H

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the European Network for Non-invasive Investigation of Large Arteries?. ### Response: Laurent S, Cockcroft J, Van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D, Pannier B, Vlachopoulos C, Wilkinson I, Struijker-Boudier H.


Instruction: What is a clini-cal perspective in arterial aging?

Output: Mechanical factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a clini-cal perspective in arterial aging?. ### Response: Mechanical factors.


Instruction: What is the European Network for Non-invasive Investigation of Large Arteries?

Output: Expert consensus document on arterial stiffness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the European Network for Non-invasive Investigation of Large Arteries?. ### Response: Expert consensus document on arterial stiffness.


Instruction: What is characterized by increased aortic stiffness and endothelial stiffness?

Output: Isolated systolic hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is characterized by increased aortic stiffness and endothelial stiffness?. ### Response: Isolated systolic hypertension.


Instruction: What is systolic hypertension characterized by?

Output: increased aortic stiffness and endothelial dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is systolic hypertension characterized by?. ### Response: increased aortic stiffness and endothelial dysfunction.


Instruction: What is endothelium-dependent dilation in the systemic arteries of asymptomatic subjects related to?

Output: coronary risk factors and their interaction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is endothelium-dependent dilation in the systemic arteries of asymptomatic subjects related to?. ### Response: coronary risk factors and their interaction.


Instruction: When did J Am Coll Cardiol. 1994;24:1468–1474?

Output: 77

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J Am Coll Cardiol. 1994;24:1468–1474?. ### Response: 77.


Instruction: How is exercise related to impaired endothelial vasodilator function?

Output: Exaggerated exercise blood pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is exercise related to impaired endothelial vasodilator function?. ### Response: Exaggerated exercise blood pressure.


Instruction: What is the name of the journal that studies exercise-related blood pressure?

Output: J Clin Hypertens

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies exercise-related blood pressure?. ### Response: J Clin Hypertens.


Instruction: When was the last issue of J Am Coll Cardiol?

Output: 1994

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last issue of J Am Coll Cardiol?. ### Response: 1994.


Instruction: How does Angiotensin II affect endothelial progenitor cell number and function in vitro and in vivo?

Output: impairs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does Angiotensin II affect endothelial progenitor cell number and function in vitro and in vivo?. ### Response: impairs.


Instruction: What are implications for vascular regeneration?

Output: Angiotensin II impairs endothelial progenitor cell number and function in vitro and in vivo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are implications for vascular regeneration?. ### Response: Angiotensin II impairs endothelial progenitor cell number and function in vitro and in vivo.


Instruction: In vivo: implications for what?

Output: vascular regeneration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In vivo: implications for what?. ### Response: vascular regeneration.


Instruction: Hypertension. 2011;58:394–403. neinnig G, Sachinidis A, Michaelsen F, Bohm M, Seewald S, Vetter H. Upregulation of what gene expression?

Output: vascular angiotensin II receptor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hypertension. 2011;58:394–403. neinnig G, Sachinidis A, Michaelsen F, Bohm M, Seewald S, Vetter H. Upregulation of what gene expression?. ### Response: vascular angiotensin II receptor.


Instruction: What is upregulated by low-density lipoprotein in vascular smooth muscle cells?

Output: vascular angiotensin II receptor gene expression

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is upregulated by low-density lipoprotein in vascular smooth muscle cells?. ### Response: vascular angiotensin II receptor gene expression.


Instruction: What stimulates angiotensin peptide synthesis and contributes to atherosclerosis?

Output: Hypercholesterolemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What stimulates angiotensin peptide synthesis and contributes to atherosclerosis?. ### Response: Hypercholesterolemia.


Instruction: What is the AT1A receptor?

Output: Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the AT1A receptor?. ### Response: Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis.


Instruction: What are the interactions between the renin-angiotensin system and dyslipidemia?

Output: relevance in the therapy of hypertension and coronary heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the interactions between the renin-angiotensin system and dyslipidemia?. ### Response: relevance in the therapy of hypertension and coronary heart disease.


Instruction: In what year was the Arch Intern Med published?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was the Arch Intern Med published?. ### Response: 2003.


Instruction: What type of receptor is used in cardiovascular disease?

Output: angiotensin II type 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of receptor is used in cardiovascular disease?. ### Response: angiotensin II type 2.


Instruction: What is the name of the non-peptide agonist that promotes natri-uresis in obese Zucker rats?

Output: C21

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the non-peptide agonist that promotes natri-uresis in obese Zucker rats?. ### Response: C21.


Instruction: What are angiotensin receptor blockers used for?

Output: pharmacol-ogy, efficacy and safety

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are angiotensin receptor blockers used for?. ### Response: pharmacol-ogy, efficacy and safety.


Instruction: What is the name of the drug that is used to block a receptor?

Output: Angiotensin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug that is used to block a receptor?. ### Response: Angiotensin.


Instruction: Where is the J Clin Hypertens located?

Output: Greenwich

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the J Clin Hypertens located?. ### Response: Greenwich.


Instruction: What indicates estimated glomerular filtration rate?

Output: eGFR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates estimated glomerular filtration rate?. ### Response: eGFR.


Instruction: What indicates potassium?

Output: Kþ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates potassium?. ### Response: Kþ.


Instruction: When were the 2013 ACCF/AHA Heart Failure Guidelines: Executive Summary published?

Output: October 15, 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When were the 2013 ACCF/AHA Heart Failure Guidelines: Executive Summary published?. ### Response: October 15, 2013.


Instruction: What does the 2014 ite ration of the VA/DoD show?

Output: absence of CV benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the 2014 ite ration of the VA/DoD show?. ### Response: absence of CV benefit.


Instruction: What is the lack of CV benefit in these populations?

Output: the data that is available

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the lack of CV benefit in these populations?. ### Response: the data that is available.


Instruction: What is a prospective multicentre study of ditis?

Output: Eur Heart J. 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a prospective multicentre study of ditis?. ### Response: Eur Heart J. 2007.


Instruction: When did Eur Heart J.28:1155-61?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Eur Heart J.28:1155-61?. ### Response: 2007.


Instruction: What did Duval X, Iung B, Klein I, et al. do?

Output: Effect of early cerebral magnetic resonance imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Duval X, Iung B, Klein I, et al. do?. ### Response: Effect of early cerebral magnetic resonance imaging.


Instruction: How did early cerebral magnetic resonance imaging affect clinical decisions in infective endocarditis: a study?

Output: Effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did early cerebral magnetic resonance imaging affect clinical decisions in infective endocarditis: a study?. ### Response: Effect.


Instruction: In what year was Ann Intern Med published?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was Ann Intern Med published?. ### Response: 2010.


Instruction: What is the difference between oral and intravenous antibi-otic treatment of endocarditis?

Output: Partial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between oral and intravenous antibi-otic treatment of endocarditis?. ### Response: Partial.


Instruction: What year was Medicine (Baltimore) published?

Output: 1978

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was Medicine (Baltimore) published?. ### Response: 1978.


Instruction: What are the 2018 Cholesterol Clinical Practice Guidelines?

Output: S4.4.4.2-5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the 2018 Cholesterol Clinical Practice Guidelines?. ### Response: S4.4.4.2-5.


Instruction: What is the lifetime risk of coronary heart disease by Lloyd-Jones D?

Output: S4.4.4.2-7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the lifetime risk of coronary heart disease by Lloyd-Jones D?. ### Response: S4.4.4.2-7.


Instruction: What is the lifetime risk of coronary heart disease by cholesterol levels at selected ages?

Output: S4.4.4.2-

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the lifetime risk of coronary heart disease by cholesterol levels at selected ages?. ### Response: S4.4.4.2-.


Instruction: What year did Arch Intern Med issue 163:1966-72?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Arch Intern Med issue 163:1966-72?. ### Response: 2003.


Instruction: Who is the author of Can we dramatically reduce the incidence of heart disease?

Output: Domanski

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of Can we dramatically reduce the incidence of heart disease?. ### Response: Domanski.


Instruction: What should cholesterol levels play a more important role in identifying statin recipients?

Output: Cholesterol levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should cholesterol levels play a more important role in identifying statin recipients?. ### Response: Cholesterol levels.


Instruction: What is the benefit model for prevention of cardiovascular disease an opportunity to harmonize guidelines?

Output: food

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the benefit model for prevention of cardiovascular disease an opportunity to harmonize guidelines?. ### Response: food.


Instruction: What are the ABCDs of lifestyle counseling?

Output: Primary care providers’ awareness of physical activity-related intensive behavioral coun-seling services for cardiovascular disease prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the ABCDs of lifestyle counseling?. ### Response: Primary care providers’ awareness of physical activity-related intensive behavioral coun-seling services for cardiovascular disease prevention.


Instruction: What is the JAMA Cardiol. 2017:2:1175-6?

Output: The benefit model for prevention of cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the JAMA Cardiol. 2017:2:1175-6?. ### Response: The benefit model for prevention of cardiovascular disease.


Instruction: What is a primary care provider's awareness of?

Output: physical activity-related intensive behavioral coun-seling services for cardiovascular disease prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a primary care provider's awareness of?. ### Response: physical activity-related intensive behavioral coun-seling services for cardiovascular disease prevention.