Instruction: How often do you need to monitor the person?

Output: every 6  months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often do you need to monitor the person?. ### Response: every 6  months.


Instruction: What drug is used in combination with nitrate 46?

Output: Hydralazine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug is used in combination with nitrate 46?. ### Response: Hydralazine.


Instruction: What is another name for Mineralcorticoid receptor antagonists?

Output: MRA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for Mineralcorticoid receptor antagonists?. ### Response: MRA.


Instruction: What is hydralazine in combination with?

Output: nitrate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hydralazine in combination with?. ### Response: nitrate.


Instruction: What is a mineralcorticoid receptor antagonist?

Output: MRA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a mineralcorticoid receptor antagonist?. ### Response: MRA.


Instruction: What is an angiotensin converting enzyme inhibitor?

Output: ACE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an angiotensin converting enzyme inhibitor?. ### Response: ACE.


Instruction: What does failure with reduced ejection fraction have if they have symptoms of heart failure?

Output: Additional treatments

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does failure with reduced ejection fraction have if they have symptoms of heart failure?. ### Response: Additional treatments.


Instruction: Measure serum sodium and potassium and assess renal function before and after an MRA and after each dose increment?

Output: 48

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Measure serum sodium and potassium and assess renal function before and after an MRA and after each dose increment?. ### Response: 48.


Instruction: What should be measured before and after each dose increment of MRA?

Output: blood pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be measured before and after each dose increment of MRA?. ### Response: blood pressure.


Instruction: What is the NICE guideline on hypertension in adults?

Output: Measure blood pressure before and after each dose increment  of MRA . Follow the recommendations on measuring blood pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the NICE guideline on hypertension in adults?. ### Response: Measure blood pressure before and after each dose increment  of MRA . Follow the recommendations on measuring blood pressure.


Instruction: What is the target dose of an MRA?

Output: maximum tolerated

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the target dose of an MRA?. ### Response: maximum tolerated.


Instruction: How often should a person monitor treatment for 3 months?

Output: monthly

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often should a person monitor treatment for 3 months?. ### Response: monthly.


Instruction: What happens if the person becomes acutely unwell?

Output: at any time the person becomes acutely unw ell

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What happens if the person becomes acutely unwell?. ### Response: at any time the person becomes acutely unw ell.


Instruction: What is Ivabradine recommended as an option for treating for people with chronic heart failure?

Output: optimised standard therapy with ACE inhibitors , beta -blockers and aldosterone antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Ivabradine recommended as an option for treating for people with chronic heart failure?. ### Response: optimised standard therapy with ACE inhibitors , beta -blockers and aldosterone antagonists.


Instruction: What is NICE technology appraisal guidance 267)?

Output: chronic heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE technology appraisal guidance 267)?. ### Response: chronic heart failure.


Instruction: What does NYHA stand for?

Output: New York Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does NYHA stand for?. ### Response: New York Heart Association.


Instruction: What is the heart rate of a person with chronic heart failure?

Output: 75 beats per minute

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the heart rate of a person with chronic heart failure?. ### Response: 75 beats per minute.


Instruction: How many beats per minute does bpm mean?

Output: 75

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many beats per minute does bpm mean?. ### Response: 75.


Instruction: What does bpm stand for?

Output: beats per minute

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does bpm stand for?. ### Response: beats per minute.


Instruction: What is ivabradine used in combination with?

Output: standard therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ivabradine used in combination with?. ### Response: standard therapy.


Instruction: How is beta -blocker therapy contraindicated?

Output: if they c ontinue to have symptoms of heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is beta -blocker therapy contraindicated?. ### Response: if they c ontinue to have symptoms of heart failure.


Instruction: What is not tolerated and  with a left ventricular ejection fraction of 35% or less?

Output: beta -blocker therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not tolerated and  with a left ventricular ejection fraction of 35% or less?. ### Response: beta -blocker therapy.


Instruction: What should only be i nitiated after a stabilisation period of 4 weeks on optimised standard therapy?

Output: Ivabradine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should only be i nitiated after a stabilisation period of 4 weeks on optimised standard therapy?. ### Response: Ivabradine.


Instruction: What is NT -proBNP?

Output: N -terminal pro -B-type natriuretic peptide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NT -proBNP?. ### Response: N -terminal pro -B-type natriuretic peptide.


Instruction: What is N -terminal pro -B-type natriuretic peptide?

Output: NT -proBNP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is N -terminal pro -B-type natriuretic peptide?. ### Response: NT -proBNP.


Instruction: Why is NT -proBNP testing likely to produce more reliable results than BNP testing?

Output: Because NT -proBNP testing is likely to produce more reliable results than BNP testing, the committee agreed that where NP monitoring is conducted, NT-proBNP should be the peptide measured

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is NT -proBNP testing likely to produce more reliable results than BNP testing?. ### Response: Because NT -proBNP testing is likely to produce more reliable results than BNP testing, the committee agreed that where NP monitoring is conducted, NT-proBNP should be the peptide measured.


Instruction: What is likely to produce more reliable results than BNP testing?

Output: NT -proBNP testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is likely to produce more reliable results than BNP testing?. ### Response: NT -proBNP testing.


Instruction: What should be the peptide measured in NP monitoring?

Output: NT-proBNP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be the peptide measured in NP monitoring?. ### Response: NT-proBNP.


Instruction: What does HFREF stand for?

Output: reduced

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does HFREF stand for?. ### Response: reduced.


Instruction: What is HFpEF?

Output: ejection fraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is HFpEF?. ### Response: ejection fraction.


Instruction: The results of the review were not formally split into what?

Output: HFREF  and HFpEF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The results of the review were not formally split into what?. ### Response: HFREF  and HFpEF.


Instruction: What percentage of patients in the included studies had HFREF?

Output: substantial majority

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients in the included studies had HFREF?. ### Response: substantial majority.


Instruction: What would have greatest benefit as part of a treatment optimisation protocol?

Output: NP monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would have greatest benefit as part of a treatment optimisation protocol?. ### Response: NP monitoring.


Instruction: Why was there no evidence for long term prognostic bene fit from pharmaceutical treatment?

Output: a treatment optimisation protocol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was there no evidence for long term prognostic bene fit from pharmaceutical treatment?. ### Response: a treatment optimisation protocol.


Instruction: What was unlikely that patients with HFPEF would receive significant benefit from NP monitoring?

Output: treatment optimisation protocol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was unlikely that patients with HFPEF would receive significant benefit from NP monitoring?. ### Response: treatment optimisation protocol.


Instruction: What was reported in the existing meta -analyses?

Output: subgroup analyses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was reported in the existing meta -analyses?. ### Response: subgroup analyses.


Instruction: What benefit of NP monitoring was found in HFREF patients but not in HFPEF patients?

Output: mortality and all -cause hos pitalisation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What benefit of NP monitoring was found in HFREF patients but not in HFPEF patients?. ### Response: mortality and all -cause hos pitalisation.


Instruction: What did the committee decide should be limited to?

Output: people with HFREF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee decide should be limited to?. ### Response: people with HFREF.


Instruction: People with heart failure and chronic kidney disease The committee considered the evidence regarding what?

Output: the use of NP -guided treatment strategies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: People with heart failure and chronic kidney disease The committee considered the evidence regarding what?. ### Response: the use of NP -guided treatment strategies.


Instruction: What did the committee consider regarding the use of NP-guided treatment strategies in patients with HF and CKD?

Output: evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee consider regarding the use of NP-guided treatment strategies in patients with HF and CKD?. ### Response: evidence.


Instruction: The committee agreed that although there was suggestion of a clinically important increase in deaths, the results were what?

Output: imprecise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committee agreed that although there was suggestion of a clinically important increase in deaths, the results were what?. ### Response: imprecise.


Instruction: How many fewer to 172 more results were there?

Output: 105

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many fewer to 172 more results were there?. ### Response: 105.


Instruction: What made it difficult for the committee to have confidence in the results?

Output: these res ults were imprecise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What made it difficult for the committee to have confidence in the results?. ### Response: these res ults were imprecise.


Instruction: There was inconsistency in what?

Output: results reported for people with HFREF  and HFpEF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There was inconsistency in what?. ### Response: results reported for people with HFREF  and HFpEF.


Instruction: What reduced the committees confidence in the results?

Output: inconsistency in the results reported for people with HFREF  and HFpEF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What reduced the committees confidence in the results?. ### Response: inconsistency in the results reported for people with HFREF  and HFpEF.


Instruction: The committee agreed that the evidence may be suggestive of a clinically significant increase in deaths with what?

Output: NP monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committee agreed that the evidence may be suggestive of a clinically significant increase in deaths with what?. ### Response: NP monitoring.


Instruction: People with HF and CKD should be monitored by who?

Output: a specialist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: People with HF and CKD should be monitored by who?. ### Response: a specialist.


Instruction: What should be monitored by a specialist?

Output: people with HF and CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be monitored by a specialist?. ### Response: people with HF and CKD.


Instruction: What did the committee note about the separate review of pharmaceutical treatment for HF in people with HF and CKD?

Output: generally concluded that most patients with CKD should be offered the same treatment options as patients without CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee note about the separate review of pharmaceutical treatment for HF in people with HF and CKD?. ### Response: generally concluded that most patients with CKD should be offered the same treatment options as patients without CKD.


Instruction: What were the treatment options as patients without CKD?

Output: HFREF ), rather than preserved (HFpEF), ejection fraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the treatment options as patients without CKD?. ### Response: HFREF ), rather than preserved (HFpEF), ejection fraction.


Instruction: What made up more than half the total number of participants in the original trials?

Output: patients wit h CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What made up more than half the total number of participants in the original trials?. ### Response: patients wit h CKD.


Instruction: Many of the included studies excluded patients with what?

Output: severe renal disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Many of the included studies excluded patients with what?. ### Response: severe renal disease.


Instruction: What was the difference in median days with incorrectadherence between the group with the daily lottery plus electronicreminder and the control group?

Output: no

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the difference in median days with incorrectadherence between the group with the daily lottery plus electronicreminder and the control group?. ### Response: no.


Instruction: What was there no effect of a daily lotteryplus electronic reminder?

Output: mortality and PE/DVT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was there no effect of a daily lotteryplus electronic reminder?. ### Response: mortality and PE/DVT.


Instruction: What did the daily lottery plus electronic reminders not have an effect on in the study?

Output: mortality and PE/DVT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the daily lottery plus electronic reminders not have an effect on in the study?. ### Response: mortality and PE/DVT.


Instruction: What was the difference in bleeding between daily lotteryplus electronic reminder group and control group?

Output: nodifference

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the difference in bleeding between daily lotteryplus electronic reminder group and control group?. ### Response: nodifference.


Instruction: How many more episodes per 1000?

Output: 14

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many more episodes per 1000?. ### Response: 14.


Instruction: What would be required for a daily lottery?

Output: use of anelectronic medication monitoring system

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would be required for a daily lottery?. ### Response: use of anelectronic medication monitoring system.


Instruction: How much would it cost to use an electronic medication monitoring system for each patient?

Output: $3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much would it cost to use an electronic medication monitoring system for each patient?. ### Response: $3.


Instruction: How much would a monitoring system be required for each patient?

Output: $3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much would a monitoring system be required for each patient?. ### Response: $3.


Instruction: What is the average cost for monetary prizes per patient per day?

Output: $3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the average cost for monetary prizes per patient per day?. ### Response: $3.


Instruction: Key stakeholders would probably not find adaily lottery acceptable in what setting?

Output: most settings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Key stakeholders would probably not find adaily lottery acceptable in what setting?. ### Response: most settings.


Instruction: What did the panel decide on based on very low quality evidence pointing toward harmfor all critical outcomes and on the intervention having high costs?

Output: a strong recommendation against theintervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the panel decide on based on very low quality evidence pointing toward harmfor all critical outcomes and on the intervention having high costs?. ### Response: a strong recommendation against theintervention.


Instruction: What approach includes situations in which strong recommendations are included?

Output: GRADE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What approach includes situations in which strong recommendations are included?. ### Response: GRADE.


Instruction: What approach includes situations in which strong recommendations are warranted despite very low certainty in evidence about the effects?

Output: GRADE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What approach includes situations in which strong recommendations are warranted despite very low certainty in evidence about the effects?. ### Response: GRADE.


Instruction: What does GRADE include situations where the panel determined there is high certainty that cost of the intervention outweighs any potential benefits?

Output: strong recommendations are warranteddespite very low certainty in evidence about the effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does GRADE include situations where the panel determined there is high certainty that cost of the intervention outweighs any potential benefits?. ### Response: strong recommendations are warranteddespite very low certainty in evidence about the effects.


Instruction: What does the ASH guideline panel suggest against using?

Output: visualmedication schedules

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the ASH guideline panel suggest against using?. ### Response: visualmedication schedules.


Instruction: What is provided to patients at each visit, along with brief counseling?

Output: visualmedication schedules

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is provided to patients at each visit, along with brief counseling?. ### Response: visualmedication schedules.


Instruction: What is the term for a recommendation based on very low certainty in the evidence about effects?

Output: con-ditional

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for a recommendation based on very low certainty in the evidence about effects?. ### Response: con-ditional.


Instruction: What was the main outcome of one RCT?

Output: timeelapsed before achieving target anticoagulant control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the main outcome of one RCT?. ### Response: timeelapsed before achieving target anticoagulant control.


Instruction: How long did it take to achieve target anticoagulant control?

Output: .35-4.38];

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take to achieve target anticoagulant control?. ### Response: .35-4.38];.


Instruction: What were the secondary outcomes of the study?

Output: TTR during the 90-day study period, mortal-ity, and hospitalizations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the secondary outcomes of the study?. ### Response: TTR during the 90-day study period, mortal-ity, and hospitalizations.


Instruction: Where is the EtD framework shown online?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the EtD framework shown online?. ### Response: https://dbep.gradepro.org.


Instruction: How much did a visual medication schedule increase TTR compared to controls?

Output: modestly

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much did a visual medication schedule increase TTR compared to controls?. ### Response: modestly.


Instruction: What was the CI included no effect on?

Output: a visual medication schedulemodestly increased TTR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the CI included no effect on?. ### Response: a visual medication schedulemodestly increased TTR.


Instruction: How much higher was the MD?

Output: 2.6%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much higher was the MD?. ### Response: 2.6%.


Instruction: What is the acronym for the ACC/AHA Task Force on Practice Guideline s?

Output: Writing Committee to Develop Guidelines for the Management ofPatients With Peripheral Arterial Disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the ACC/AHA Task Force on Practice Guideline s?. ### Response: Writing Committee to Develop Guidelines for the Management ofPatients With Peripheral Arterial Disease.


Instruction: What are the acronyms for the Writing Committee to Develop Guidelines for the Management of Patients With Peripheral Arterial Disease?

Output: ACC/AHA Task Force on Practice Guideline s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the acronyms for the Writing Committee to Develop Guidelines for the Management of Patients With Peripheral Arterial Disease?. ### Response: ACC/AHA Task Force on Practice Guideline s.


Instruction: Circulation. 2006;113:1474–1547.

Output: Society for Vascular Medicine and Biology, Society of InterventionalRadiology, and the ACC/AHA Task Force on Practice Guideline s(Writing Committee to Develop Guidelines for the Management ofPatients With Peripheral Arterial Disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation. 2006;113:1474–1547.. ### Response: Society for Vascular Medicine and Biology, Society of InterventionalRadiology, and the ACC/AHA Task Force on Practice Guideline s(Writing Committee to Develop Guidelines for the Management ofPatients With Peripheral Arterial Disease.


Instruction: What is a risk factor for cardiovascular disease?

Output: H18546

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for cardiovascular disease?. ### Response: H18546.


Instruction: What is the name of the AHA/ACCF Secondary Prevention: 2011 Update 2473Downloaded from http://ahajournals.org by on May 1, 2023

Output: Smith et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the AHA/ACCF Secondary Prevention: 2011 Update 2473Downloaded from http://ahajournals.org by on May 1, 2023. ### Response: Smith et al.


Instruction: What are patients with no apparent structural heart disease referred to as?

Output: idiopathic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients with no apparent structural heart disease referred to as?. ### Response: idiopathic.


Instruction: What is idiopathic?

Output: VA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is idiopathic?. ### Response: VA.


Instruction: Genetic arrhythmia syndrome are commonly referred to as what?

Output: idiopathic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Genetic arrhythmia syndrome are commonly referred to as what?. ### Response: idiopathic.


Instruction: Most idiopathic VA are based on a focal mecha-nism of triggered activity or abnormal automaticity.

Output: monomorphic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Most idiopathic VA are based on a focal mecha-nism of triggered activity or abnormal automaticity.. ### Response: monomorphic.


Instruction: What are some patients due to?

Output: reentry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some patients due to?. ### Response: reentry.


Instruction: Patients who are symptomatic and antiarrhythmic medications are ineffective, not tolerated, or what else?

Output: not desired by the patient

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients who are symptomatic and antiarrhythmic medications are ineffective, not tolerated, or what else?. ### Response: not desired by the patient.


Instruction: What is a treatment option for antiarrhythmic medications?

Output: catheter ablation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a treatment option for antiarrhythmic medications?. ### Response: catheter ablation.


Instruction: What is the ablation strategy to identify the site of origin mani-fested by the earliest site of electrical activation?

Output: substrate mapping

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ablation strategy to identify the site of origin mani-fested by the earliest site of electrical activation?. ### Response: substrate mapping.


Instruction: What is not practical, by pace mapping?

Output: electrical activation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not practical, by pace mapping?. ### Response: electrical activation.


Instruction: Catheter ablation of idiopathic VA is usually accomplished with what?

Output: endocardial catheterization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Catheter ablation of idiopathic VA is usually accomplished with what?. ### Response: endocardial catheterization.


Instruction: An epicardial ap-proach through the coronary venous circulation or a subxiphoid pericardial puncture may occasionally be required.

Output: circulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: An epicardial ap-proach through the coronary venous circulation or a subxiphoid pericardial puncture may occasionally be required.. ### Response: circulation.


Instruction: What is often due to inability to provoke the arrhythmia to allow ablation failure?

Output: idiopathic VA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is often due to inability to provoke the arrhythmia to allow ablation failure?. ### Response: idiopathic VA.


Instruction: What is a common cause of sustained monomorphic VT?

Output: reentry through regions of surviving myocardial fibers associated with areas of fibrous scar

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a common cause of sustained monomorphic VT?. ### Response: reentry through regions of surviving myocardial fibers associated with areas of fibrous scar.


Instruction: What is an example of scar-related VT in heart disease?

Output: VTSee Section 8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of scar-related VT in heart disease?. ### Response: VTSee Section 8.


Instruction: What is the ablation strategy for re-entry circuits?

Output: substrate mapping

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ablation strategy for re-entry circuits?. ### Response: substrate mapping.


Instruction: What is often associated with slow conduction facilitating reentry?

Output: the scar

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is often associated with slow conduction facilitating reentry?. ### Response: the scar.


Instruction: Where is the substrate in VTs that are related to prior MI?

Output: subendocardial surface of the left ventricle

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the substrate in VTs that are related to prior MI?. ### Response: subendocardial surface of the left ventricle.


Instruction: In NICM, the reentrant circuits are more variable in loca-tion, often involve what?

Output: the epicardial surface of either ven-tricle

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In NICM, the reentrant circuits are more variable in loca-tion, often involve what?. ### Response: the epicardial surface of either ven-tricle.


Instruction: Where may ablation be difficult to achieve?

Output: from either surface

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where may ablation be difficult to achieve?. ### Response: from either surface.


Instruction: In tetralogy of Fallot specific reentry paths have been defined.

Output: S5.4.3-1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In tetralogy of Fallot specific reentry paths have been defined.. ### Response: S5.4.3-1.


Instruction: What helps clarify the relation of electrophysiologi-cal abnormalities to cardiac anatomy?

Output: map-ping

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What helps clarify the relation of electrophysiologi-cal abnormalities to cardiac anatomy?. ### Response: map-ping.


Instruction: Areas of scar can be appreciated as regions of what?

Output: relatively low electrogram voltage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Areas of scar can be appreciated as regions of what?. ### Response: relatively low electrogram voltage.


Instruction: What can be appreciated as regions of relatively low electrogram voltage?

Output: Areas of scar

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be appreciated as regions of relatively low electrogram voltage?. ### Response: Areas of scar.


Instruction: What often limits mapping during scar-related VTs?

Output: hemodynamic intolerance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What often limits mapping during scar-related VTs?. ### Response: hemodynamic intolerance.


Instruction: Ablation is then often guided by what?

Output: substrate mapping

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Ablation is then often guided by what?. ### Response: substrate mapping.


Instruction: What are delineated in electroanatomic maps based on electrocardiographic and pacing characteristics as-sessed during hemodynamically stable sinus or paced rhythm?

Output: areas of scar and potential reentry circuit sub-strate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are delineated in electroanatomic maps based on electrocardiographic and pacing characteristics as-sessed during hemodynamically stable sinus or paced rhythm?. ### Response: areas of scar and potential reentry circuit sub-strate.


Instruction: What requires advanced level of experience by the operator, electro-physiological laboratory staff, and anesthesiologists?

Output: Catheter ablation of scar-related VT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What requires advanced level of experience by the operator, electro-physiological laboratory staff, and anesthesiologists?. ### Response: Catheter ablation of scar-related VT.


Instruction: What types of equipment are available for surgical back-up?

Output: specialized mapping, imaging, and ablation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What types of equipment are available for surgical back-up?. ### Response: specialized mapping, imaging, and ablation.


Instruction: What type of equipment is available for mapping, imaging and ablation?

Output: surgical back-up

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of equipment is available for mapping, imaging and ablation?. ### Response: surgical back-up.


Instruction: What is the frequency of medical complications after acute stroke?

Output: high

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the frequency of medical complications after acute stroke?. ### Response: high.


Instruction: What is more information reported for ischemic stroke than ICH?

Output: medical complications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more information reported for ischemic stroke than ICH?. ### Response: medical complications.


Instruction: In a trial, what was NXY-059 used in?

Output: patients with sponta-neous ICH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In a trial, what was NXY-059 used in?. ### Response: patients with sponta-neous ICH.


Instruction: What is the acronym for Cerebral Hematoma and NXY Treatment?

Output: CHANT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Cerebral Hematoma and NXY Treatment?. ### Response: CHANT.


Instruction: In patients with sponta-neous ICH, how many adverse events were reported in 88% of the placebo-treated patients?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with sponta-neous ICH, how many adverse events were reported in 88% of the placebo-treated patients?. ### Response: 1.


Instruction: How many of the adverse events reported were serious?

Output: 40%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many of the adverse events reported were serious?. ### Response: 40%.


Instruction: What were the most common complications?

Output: pneumonia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the most common complications?. ### Response: pneumonia.


Instruction: What is the most common complication of stroke?

Output: pneumonia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common complication of stroke?. ### Response: pneumonia.


Instruction: What percentage of stroke deaths are attributed to medical complications?

Output: 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of stroke deaths are attributed to medical complications?. ### Response: 50%.


Instruction: How long does it usually take for stroke patients to be hospitalized?

Output: 7 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it usually take for stroke patients to be hospitalized?. ### Response: 7 days.


Instruction: What are two major risk factors for the development of pneumonia?

Output: Dysphagia and aspiration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are two major risk factors for the development of pneumonia?. ### Response: Dysphagia and aspiration.


Instruction: Dysphagia is defined by swal-lowing impairment of the upper digestive tract and includes impairments in swallowing efficiency and safety?

Output: delays in the timing of movements, reduced range of movements, and frank aspiration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Dysphagia is defined by swal-lowing impairment of the upper digestive tract and includes impairments in swallowing efficiency and safety?. ### Response: delays in the timing of movements, reduced range of movements, and frank aspiration.


Instruction: What is a sign of severe dysphagia?

Output: Aspiration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a sign of severe dysphagia?. ### Response: Aspiration.


Instruction: What refers to abnormal entry of fluid, particulate exogenous substances, or endogenous secretions into the airways?

Output: Aspiration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What refers to abnormal entry of fluid, particulate exogenous substances, or endogenous secretions into the airways?. ### Response: Aspiration.


Instruction: How many Japanese ICH patients could not tolerate oral feed-ing?

Output: 68%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many Japanese ICH patients could not tolerate oral feed-ing?. ### Response: 68%.


Instruction: How many German patients required percutaneous endoscopic gastrostomy?

Output: 25%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many German patients required percutaneous endoscopic gastrostomy?. ### Response: 25%.


Instruction: What were independent risk factors in this study?

Output: GCS, occlusive hydrocephalus, mechanical venti-lation, and sepsis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were independent risk factors in this study?. ### Response: GCS, occlusive hydrocephalus, mechanical venti-lation, and sepsis.


Instruction: What were independent risk factors for dyspha-gia and percutaneous endoscopic gastrostomy placement?

Output: psis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were independent risk factors for dyspha-gia and percutaneous endoscopic gastrostomy placement?. ### Response: psis.


Instruction: What was associated with a significantly reduced risk of ischemic stroke in a prospective multicenter study?

Output: use of a formal screen-ing protocol for dysphagia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with a significantly reduced risk of ischemic stroke in a prospective multicenter study?. ### Response: use of a formal screen-ing protocol for dysphagia.


Instruction: What was associated with a significantly reduced risk of pneumonia compared with no formal screen?

Output: use of a formal screen-ing protocol for dysphagia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with a significantly reduced risk of pneumonia compared with no formal screen?. ### Response: use of a formal screen-ing protocol for dysphagia.


Instruction: What was the pneu-monia rate of sites without a screen versus 5.4% of those without?

Output: 2.4%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the pneu-monia rate of sites without a screen versus 5.4% of those without?. ### Response: 2.4%.


Instruction: How much absolute risk reduction did ischemic stroke have?

Output: 3%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much absolute risk reduction did ischemic stroke have?. ### Response: 3%.


Instruction: What is the absolute risk reduction?

Output: 3%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the absolute risk reduction?. ### Response: 3%.


Instruction: What may be caused by acute myocardial infarction (MI), heart failure, ventricular arrhythmias, and cardiac arrest?

Output: Serious cardiac events and cardiac death after stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be caused by acute myocardial infarction (MI), heart failure, ventricular arrhythmias, and cardiac arrest?. ### Response: Serious cardiac events and cardiac death after stroke.


Instruction: Concurrent stroke and MI are not uncommon.

Output: Serious cardiac events and cardiac death after stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Concurrent stroke and MI are not uncommon.. ### Response: Serious cardiac events and cardiac death after stroke.


Instruction: How many ICH patients were included in the prospective Austrian Stroke Unit Registry?

Output: 4984

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many ICH patients were included in the prospective Austrian Stroke Unit Registry?. ### Response: 4984.


Instruction: What percentage of patients had an MI over a median duration of 3 days?

Output: 0.3%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients had an MI over a median duration of 3 days?. ### Response: 0.3%.


Instruction: What type of stroke is associated with the development of pneumonia?

Output: Dysphagia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of stroke is associated with the development of pneumonia?. ### Response: Dysphagia.


Instruction: What is the name of the condition that can be associated with MI?

Output: acute myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the condition that can be associated with MI?. ### Response: acute myocardial infarction.


Instruction: Along with the severity of deficits on admission, what other condition can be linked to MI and stroke?

Output: pneumonia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Along with the severity of deficits on admission, what other condition can be linked to MI and stroke?. ### Response: pneumonia.


Instruction: How many days after the index procedure were patients randomized to staged revascularization?

Output: 3 to 40

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many days after the index procedure were patients randomized to staged revascularization?. ### Response: 3 to 40.


Instruction: How long did it take for patients to stage their PCI 1139STEMI?

Output: 3 to 40 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for patients to stage their PCI 1139STEMI?. ### Response: 3 to 40 days.


Instruction: What type of PCI was used?

Output: multivessel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of PCI was used?. ### Response: multivessel.


Instruction: How many months’ mean follow-up showed no between-group differences in the composite primary endpoint of all-cause death, nonfatal MI, and stroke?

Output: 38

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many months’ mean follow-up showed no between-group differences in the composite primary endpoint of all-cause death, nonfatal MI, and stroke?. ### Response: 38.


Instruction: The prior Class III (Harm) recommendation with regard to multivessel primary PCI in hemodynamically stable patients with STEMI has been upgraded to what?

Output: Class IIb

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The prior Class III (Harm) recommendation with regard to multivessel primary PCI in hemodynamically stable patients with STEMI has been upgraded to what?. ### Response: Class IIb.


Instruction: What is a Class IIb recommendation for STEMI?

Output: multivessel PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a Class IIb recommendation for STEMI?. ### Response: multivessel PCI.


Instruction: What should patients with STEMI consider at the time of primary PCI or as a planned, staged procedure?

Output: multivessel PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients with STEMI consider at the time of primary PCI or as a planned, staged procedure?. ### Response: multivessel PCI.


Instruction: The writ-ing committee emphasizes that this change should not be interpreted as endorsing what?

Output: the routine performance of multives-sel PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The writ-ing committee emphasizes that this change should not be interpreted as endorsing what?. ### Response: the routine performance of multives-sel PCI.


Instruction: What should not be interpreted as endorsing the routine performance of multives-sel PCI in all patients with STEMI and multivessel disease?

Output: primary PCI in hemodynamically stable patients with STEMI has been upgraded and modified to a Class IIb recommendation to include consideration of multivessel PCI, either at the time of primary PCI or as a planned, staged procedure. The writ-ing committee emphasizes that this change

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not be interpreted as endorsing the routine performance of multives-sel PCI in all patients with STEMI and multivessel disease?. ### Response: primary PCI in hemodynamically stable patients with STEMI has been upgraded and modified to a Class IIb recommendation to include consideration of multivessel PCI, either at the time of primary PCI or as a planned, staged procedure. The writ-ing committee emphasizes that this change.


Instruction: What should physicians integrate clinical data, lesion severity/complexity, and risk of contrast nephropathy to determine the optimal strategy?

Output: multivessel PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should physicians integrate clinical data, lesion severity/complexity, and risk of contrast nephropathy to determine the optimal strategy?. ### Response: multivessel PCI.


Instruction: What does contrast nephropathy determine?

Output: optimal strategy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does contrast nephropathy determine?. ### Response: optimal strategy.


Instruction: What is the strategy of routine PCI of noninfarct related arteries in hemodynamically stable patients?

Output: recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the strategy of routine PCI of noninfarct related arteries in hemodynamically stable patients?. ### Response: recommendations.


Instruction: What type of PCI is associated with multivessel staged PCI?

Output: primary PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of PCI is associated with multivessel staged PCI?. ### Response: primary PCI.


Instruction: What is the term for patients who have spontaneous symptoms and myocardial ischemia?

Output: STEMI guideline with regard to PCI of a non–infarct-related artery at a time separate from primary PCI in patients who have spontaneous symptoms and myocardial ischemia or who have intermediate- or high-risk findings on noninva-sive testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for patients who have spontaneous symptoms and myocardial ischemia?. ### Response: STEMI guideline with regard to PCI of a non–infarct-related artery at a time separate from primary PCI in patients who have spontaneous symptoms and myocardial ischemia or who have intermediate- or high-risk findings on noninva-sive testing.


Instruction: What may be associated with better outcome than multivessel staged PCI?

Output: more patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be associated with better outcome than multivessel staged PCI?. ### Response: more patients.


Instruction: What are there insufficient observational data and no randomized data at this time to inform a recommenda-tion regarding the optimal timing of?

Output: nonculprit vessel PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are there insufficient observational data and no randomized data at this time to inform a recommenda-tion regarding the optimal timing of?. ### Response: nonculprit vessel PCI.


Instruction: What is awaited to help clarify vessel PCI?

Output: Additional trial data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is awaited to help clarify vessel PCI?. ### Response: Additional trial data.


Instruction: What are issues related to the optimal method of evaluating nonculprit lesions?

Output: percent diameter stenosis, fractional flow reserve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are issues related to the optimal method of evaluating nonculprit lesions?. ### Response: percent diameter stenosis, fractional flow reserve.


Instruction: What did the 2011 PCI and 2013 STEMI guidelines recommend?

Output: aspiration thrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the 2011 PCI and 2013 STEMI guidelines recommend?. ### Response: aspiration thrombectomy.


Instruction: What was the Class IIa recommendation for aspiration thrombectomy?

Output: before primary PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the Class IIa recommendation for aspiration thrombectomy?. ### Response: before primary PCI.


Instruction: How many patients with STEMI were randomized to aspiration thrombectomy before or after primary PCI?

Output: 1071

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with STEMI were randomized to aspiration thrombectomy before or after primary PCI?. ### Response: 1071.


Instruction: How many multicenter trials were conducted in TAPAS?

Output: Three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many multicenter trials were conducted in TAPAS?. ### Response: Three.


Instruction: What was the name of the single-center study that randomized 1071 patients?

Output: TAPAS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the single-center study that randomized 1071 patients?. ### Response: TAPAS.


Instruction: How many multicenter trials enrolled signifi-cantly more patients than prior aspiration thrombectomy?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many multicenter trials enrolled signifi-cantly more patients than prior aspiration thrombectomy?. ### Response: 2.


Instruction: How much did the prevalence increase for men and women?

Output: 35.0%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much did the prevalence increase for men and women?. ### Response: 35.0%.


Instruction: What was the highest prevalence in subjects between 60 and 69 years of age?

Output: Prevalence increased with age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the highest prevalence in subjects between 60 and 69 years of age?. ### Response: Prevalence increased with age.


Instruction: Why was the prevalence lower among black men than white or Mexican American men?

Output: obligatory use of a lower waist circumference for the IDF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the prevalence lower among black men than white or Mexican American men?. ### Response: obligatory use of a lower waist circumference for the IDF.


Instruction: What did the IDF definition lead to higher estimates of prevalence in?

Output: all demographic groups

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the IDF definition lead to higher estimates of prevalence in?. ### Response: all demographic groups.


Instruction: What is an important marker of the metabolic syndrome?

Output: Hyperinsulinemia/insulin resistance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an important marker of the metabolic syndrome?. ### Response: Hyperinsulinemia/insulin resistance.


Instruction: What is the relationship between glucose intolerance and stroke risk?

Output: conflicting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the relationship between glucose intolerance and stroke risk?. ### Response: conflicting.


Instruction: How many people were screened for entry into the Diabetes Reduction Assessment with Ramipril and Rosiglitazone Medication trial from 21 different countries?

Output: 18 990

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were screened for entry into the Diabetes Reduction Assessment with Ramipril and Rosiglitazone Medication trial from 21 different countries?. ### Response: 18 990.


Instruction: How many countries participated in the Rosiglitazone Medication trial?

Output: 21

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many countries participated in the Rosiglitazone Medication trial?. ### Response: 21.


Instruction: How many of the subjects in the DREAM trial were normoglyce-mic?

Output: 8000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many of the subjects in the DREAM trial were normoglyce-mic?. ### Response: 8000.


Instruction: What type of diabetes was diagnosed in 2563 people?

Output: type 2 diabetes mel-litus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diabetes was diagnosed in 2563 people?. ### Response: type 2 diabetes mel-litus.


Instruction: What was the HR of a 45-mg/dL increase in glucose after an oral glucose tolerance test?

Output: 1.17

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the HR of a 45-mg/dL increase in glucose after an oral glucose tolerance test?. ### Response: 1.17.


Instruction: What is the 95% confidence interval between 1.13 and1.22?

Output: 1.17

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 95% confidence interval between 1.13 and1.22?. ### Response: 1.17.


Instruction: How are the relationships between metabolic syndrome and stroke risk reviewed?

Output: in other sec-tions of this guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are the relationships between metabolic syndrome and stroke risk reviewed?. ### Response: in other sec-tions of this guideline.


Instruction: What is a predictor of CVD and vascular death?

Output: The metabolic syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a predictor of CVD and vascular death?. ### Response: The metabolic syndrome.


Instruction: What does the metabolic syndrome predict?

Output: CVD and vascular death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the metabolic syndrome predict?. ### Response: CVD and vascular death.


Instruction: What are the components of the syndrome?

Output: Hyperinsulinemia/insulin resistance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the components of the syndrome?. ### Response: Hyperinsulinemia/insulin resistance.


Instruction: What is the lack of greater predictability true for?

Output: metabolic syndrome and stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the lack of greater predictability true for?. ### Response: metabolic syndrome and stroke.


Instruction: Why is there a lack of relationship between metabolic syndrome and stroke?

Output: sample size

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is there a lack of relationship between metabolic syndrome and stroke?. ### Response: sample size.


Instruction: How many subjects participated in the National Health and Nutrition Examination Survey?

Output: 10 357

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many subjects participated in the National Health and Nutrition Examination Survey?. ### Response: 10 357.


Instruction: How many subjects participated in the Examination Survey?

Output: 10 357

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many subjects participated in the Examination Survey?. ### Response: 10 357.


Instruction: What was the prevalence of metabolic syndrome in people with self-reported history of stroke?

Output: 43.5%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the prevalence of metabolic syndrome in people with self-reported history of stroke?. ### Response: 43.5%).


Instruction: What was independently associated with stroke history in all ethnic groups and in both sexes?

Output: The metabolic syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was independently associated with stroke history in all ethnic groups and in both sexes?. ### Response: The metabolic syndrome.


Instruction: The association between metabolic syndrome and stroke has been confirmed in other populations, including those enriched with elderly subjects?

Output: subjects,643

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The association between metabolic syndrome and stroke has been confirmed in other populations, including those enriched with elderly subjects?. ### Response: subjects,643.


Instruction: What was notably higher in patients with metabolic syndrome?

Output: self-reported history of stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was notably higher in patients with metabolic syndrome?. ### Response: self-reported history of stroke.


Instruction: What was notably higher in patients with a history of nonhemorrhagic stroke?

Output: meta-bolic syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was notably higher in patients with a history of nonhemorrhagic stroke?. ### Response: meta-bolic syndrome.


Instruction: What was higher in Korean patients with spontaneous ICH?

Output: meta-bolic syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was higher in Korean patients with spontaneous ICH?. ### Response: meta-bolic syndrome.


Instruction: The adjusted RRs for ischemic stroke asso-ciated with the metabolic syndrome in prospective studies ranged between what?

Output: 2.10 and 2.47

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The adjusted RRs for ischemic stroke asso-ciated with the metabolic syndrome in prospective studies ranged between what?. ### Response: 2.10 and 2.47.


Instruction: What is the HR as high as?

Output: 1.17

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the HR as high as?. ### Response: 1.17.


Instruction: What does not appear to be influenced by the definition used for the metabolic syndrome?

Output: predictive capacity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not appear to be influenced by the definition used for the metabolic syndrome?. ### Response: predictive capacity.


Instruction: What are the common cardiovascular and noncardiovascular complications in patients with HFrEF?

Output: central sleep apnea

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the common cardiovascular and noncardiovascular complications in patients with HFrEF?. ### Response: central sleep apnea.


Instruction: What is the current AHA/ACC/HRS Guideline for the Management of Patients with Atrial Fibrillation?

Output: Strong Intermediate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the current AHA/ACC/HRS Guideline for the Management of Patients with Atrial Fibrillation?. ### Response: Strong Intermediate.


Instruction: CardiovascularCoronary arterydiseaseStrong StrongnEvaluate and revascularize in appropriate patients?

Output: Atrial ﬁbrillation/ﬂutterStrong Intermediate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: CardiovascularCoronary arterydiseaseStrong StrongnEvaluate and revascularize in appropriate patients?. ### Response: Atrial ﬁbrillation/ﬂutterStrong Intermediate.


Instruction: What is the current AHA/ACC Guideline for theManagement of Patients with Valvular Heart Disease?

Output: 160,161)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the current AHA/ACC Guideline for theManagement of Patients with Valvular Heart Disease?. ### Response: 160,161).


Instruction: What is ACC ECDP on the Management of MR?

Output: 162

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ACC ECDP on the Management of MR?. ### Response: 162.


Instruction: What type of intervention is recommended in patients with symptomatic HF and secondary MR?

Output: transcatheter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of intervention is recommended in patients with symptomatic HF and secondary MR?. ### Response: transcatheter.


Instruction: What are the current AHA/ACC Guidelines for theManagement of Patients with Valvular Heart Disease?

Output: 160,161)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the current AHA/ACC Guidelines for theManagement of Patients with Valvular Heart Disease?. ### Response: 160,161).


Instruction: What are the current ACC/AHA Guidelines for the Prevention, Detection, Evaluation, and Management of HighBlood Pressure in Adults?

Output: Pre-vention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the current ACC/AHA Guidelines for the Prevention, Detection, Evaluation, and Management of HighBlood Pressure in Adults?. ### Response: Pre-vention.


Instruction: What is the current AHA/ACC Guidelines on the Management of Blood Cholesterol?

Output: 165

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the current AHA/ACC Guidelines on the Management of Blood Cholesterol?. ### Response: 165.


Instruction: What does the ACC ECDP on the Role of Non-Statin Therapies for LDL-Cholesterol Lowering in the Management of ASCVD Risk do?

Output: prevention nTreat

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the ACC ECDP on the Role of Non-Statin Therapies for LDL-Cholesterol Lowering in the Management of ASCVD Risk do?. ### Response: prevention nTreat.


Instruction: What is the current AHA/ACC Guidelines on the Man-agement of Patients With Lower Extremity Peripheral ArteryDisease?

Output: Peripheral vasculardiseaseModerate NonenTreat

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the current AHA/ACC Guidelines on the Man-agement of Patients With Lower Extremity Peripheral ArteryDisease?. ### Response: Peripheral vasculardiseaseModerate NonenTreat.


Instruction: What are the current ASA/AHA Guidelines for the EarlyManagement of Patients wi th Acute Ischemic Stroke?

Output: CerebrovasculardiseaseModerate WeaknTreat

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the current ASA/AHA Guidelines for the EarlyManagement of Patients wi th Acute Ischemic Stroke?. ### Response: CerebrovasculardiseaseModerate WeaknTreat.


Instruction: What is the ACC ECDP on Novel Therapies for CVR?

Output: consult with endocrinologistnTreat

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ACC ECDP on Novel Therapies for CVR?. ### Response: consult with endocrinologistnTreat.


Instruction: What is ACC ECDP on Novel Therapies for CVR i s kR e d u c ti o ni nP a t ie nt sw?

Output: consult with endocrinologist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ACC ECDP on Novel Therapies for CVR i s kR e d u c ti o ni nP a t ie nt sw?. ### Response: consult with endocrinologist.


Instruction: What are ADA Standardsof Medical Care in Diabetes?

Output: Chronic kidneydisease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are ADA Standardsof Medical Care in Diabetes?. ### Response: Chronic kidneydisease.


Instruction: What type of kidneydisease isStrong Strong nOptimize RAAS inhibitor therapynUse hydralazine/ISDN if an ARNI/ACEI/ARB cannot be usednAdminister SGLT2 inhibitornConsider nephrology consultAnemia Moderate Weak nEvaluate secondary causesn Consider transfusion in severe cases?

Output: Chronic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of kidneydisease isStrong Strong nOptimize RAAS inhibitor therapynUse hydralazine/ISDN if an ARNI/ACEI/ARB cannot be usednAdminister SGLT2 inhibitornConsider nephrology consultAnemia Moderate Weak nEvaluate secondary causesn Consider transfusion in severe cases?. ### Response: Chronic.


Instruction: What is harmful in patients with symptomaticHFrEF and central sleep apnea?

Output: adaptive servo-ventilation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is harmful in patients with symptomaticHFrEF and central sleep apnea?. ### Response: adaptive servo-ventilation.


Instruction: What is recommended to treat sleep disorderedbreathingStrong Intermediate?

Output: intraven

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended to treat sleep disorderedbreathingStrong Intermediate?. ### Response: intraven.


Instruction: What are the 2018 Cholesterol Clinical Practice Guidelines?

Output: e1082–e1143

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the 2018 Cholesterol Clinical Practice Guidelines?. ### Response: e1082–e1143.


Instruction: What is the 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholerol?

Output: Author Relationships With Industry and Other Entities (Relevant)—2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol*

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholerol?. ### Response: Author Relationships With Industry and Other Entities (Relevant)—2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol*.


Instruction: What is the current title of the Scott M. Grundy ChairVA North Texas Health Care System and University of Texas Southwestern Medical Center at Dallas?

Output: —Professor of Internal Medicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the current title of the Scott M. Grundy ChairVA North Texas Health Care System and University of Texas Southwestern Medical Center at Dallas?. ### Response: —Professor of Internal Medicine.


Instruction: Who is Professor of Medicine at the University of Tennessee?

Output: Alison L. Bailey Erlanger

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Professor of Medicine at the University of Tennessee?. ### Response: Alison L. Bailey Erlanger.


Instruction: Who is the Program Director of Cardiovascular Diseases Fellowship?

Output: Alison L. Bailey Erlanger

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Program Director of Cardiovascular Diseases Fellowship?. ### Response: Alison L. Bailey Erlanger.


Instruction: What is the name of the Managing Director of CBRE?

Output: Craig Beam

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Managing Director of CBRE?. ### Response: Craig Beam.


Instruction: What is the name of the professor at the University of Houston College of Pharmacy?

Output: Kim K. Birtcher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor at the University of Houston College of Pharmacy?. ### Response: Kim K. Birtcher.


Instruction: Who is the professor of medicine at the Ciccarone Center for the Prevention of Heart Disease?

Output: Roger S. Blumenthal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the professor of medicine at the Ciccarone Center for the Prevention of Heart Disease?. ### Response: Roger S. Blumenthal.


Instruction: What is the name of the professor of nursing and medicine at T. Braun Rush University Medical Center?

Output: Lynne

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor of nursing and medicine at T. Braun Rush University Medical Center?. ### Response: Lynne.


Instruction: Who is the assistant professor of pediatrics at Boston Children’s Hospital?

Output: Sarah De Ferranti

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the assistant professor of pediatrics at Boston Children’s Hospital?. ### Response: Sarah De Ferranti.


Instruction: What is the name of the professor of medicine at the University of Miami?

Output: Ronald Goldberg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor of medicine at the University of Miami?. ### Response: Ronald Goldberg.


Instruction: Who is the Vice Chair of Quality at Stanford University?

Output: Paul A. Heidenreich

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Vice Chair of Quality at Stanford University?. ### Response: Paul A. Heidenreich.


Instruction: What is Mark A. Hlatky Stanford University, School of Medicine Professor of?

Output: Cardiovascular Medicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Mark A. Hlatky Stanford University, School of Medicine Professor of?. ### Response: Cardiovascular Medicine.


Instruction: What is Daniel W. Jones University of Mississippi Medical Center Professor of Medicine and Physiology?

Output: Director, Clinical and Population Science

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Daniel W. Jones University of Mississippi Medical Center Professor of Medicine and Physiology?. ### Response: Director, Clinical and Population Science.


Instruction: What is the name of the professor of medicine and physiology at Northwestern University?

Output: Donald Lloyd-Jones

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor of medicine and physiology at Northwestern University?. ### Response: Donald Lloyd-Jones.


Instruction: Who is the chair of the Department of Preventive Medicine at Northwestern?

Output: Donald Lloyd-Jones

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the chair of the Department of Preventive Medicine at Northwestern?. ### Response: Donald Lloyd-Jones.


Instruction: Which professor is the head of the Johns Hopkins University School of Medicine?

Output: Roger S. Blumenthal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which professor is the head of the Johns Hopkins University School of Medicine?. ### Response: Roger S. Blumenthal.


Instruction: What is the name of the assistant professor of medicine at Johns Hopkins University School of Medicine?

Output: Chiadi Ndumele

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the assistant professor of medicine at Johns Hopkins University School of Medicine?. ### Response: Chiadi Ndumele.


Instruction: What is another name for an angiotensin-converting enzyme inhibitor?

Output: angiotensin II receptor blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for an angiotensin-converting enzyme inhibitor?. ### Response: angiotensin II receptor blocker.


Instruction: What is a monotherapy for hypertension in African American patients?

Output: angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a monotherapy for hypertension in African American patients?. ### Response: angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker.


Instruction: What is a primary pharmacologic therapy for HTN for reduction in composite cardiovascular outcomes in this CPG?

Output: a thiazide -type diuretic or CCB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a primary pharmacologic therapy for HTN for reduction in composite cardiovascular outcomes in this CPG?. ### Response: a thiazide -type diuretic or CCB.


Instruction: What are thiazide -type diuretic or CCB?

Output: In addition to being recommended as primary pharmacologic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are thiazide -type diuretic or CCB?. ### Response: In addition to being recommended as primary pharmacologic therapy.


Instruction: What is the name of the procedure used to treat strokes?

Output: Device therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the procedure used to treat strokes?. ### Response: Device therapy.


Instruction: What is another term for intracranial hem-orrhage?

Output: Major extracranialhemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for intracranial hem-orrhage?. ### Response: Major extracranialhemorrhage.


Instruction: How many strokes are there?

Output: All stroke- Ischemic stroke- Systemicembolism- Intracranial hem-orrhage (subdural,subarachnoid, andintracerebral)- Major extracranialhemorrhage-M I- Vascular deathSRRCTsCohort studies(Continued)chestjournal.org 1133

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes are there?. ### Response: All stroke- Ischemic stroke- Systemicembolism- Intracranial hem-orrhage (subdural,subarachnoid, andintracerebral)- Major extracranialhemorrhage-M I- Vascular deathSRRCTsCohort studies(Continued)chestjournal.org 1133.


Instruction: What procedure is used to treat AF andrheumatic heart disease?

Output: mitral stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What procedure is used to treat AF andrheumatic heart disease?. ### Response: mitral stenosis.


Instruction: What is the term for Intracranial hem-orrhage?

Output: Major extracranialhemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for Intracranial hem-orrhage?. ### Response: Major extracranialhemorrhage.


Instruction: What is the name of the disease that causes mitral stenosis?

Output: rheumatic heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease that causes mitral stenosis?. ### Response: rheumatic heart disease.


Instruction: What type of stroke is the most common cause of death?

Output: Ischemic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of stroke is the most common cause of death?. ### Response: Ischemic.


Instruction: What is the PREVAIL trial?

Output: Watchman Left Atrial Appendage Closure device

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the PREVAIL trial?. ### Response: Watchman Left Atrial Appendage Closure device.


Instruction: What is left atrial appendage closure as an alternative to warfarin for?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is left atrial appendage closure as an alternative to warfarin for?. ### Response: stroke.


Instruction: What is an alternative to warfarin for stroke Prevention in atrial fibrillation?

Output: Left atrial appendage closure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an alternative to warfarin for stroke Prevention in atrial fibrillation?. ### Response: Left atrial appendage closure.


Instruction: What is a patient-level meta-analysis?

Output: Left atrial appendage closure as an alternative to warfarin for stroke Prevention in atrial fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a patient-level meta-analysis?. ### Response: Left atrial appendage closure as an alternative to warfarin for stroke Prevention in atrial fibrillation.


Instruction: When did J Am Coll Cardiol. 2015 issue 65:2614-23?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J Am Coll Cardiol. 2015 issue 65:2614-23?. ### Response: 2015.


Instruction: How did the US experience post-approval US experience with left atrial appendage closure?

Output: stroke prevention in atrial fibrilla-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did the US experience post-approval US experience with left atrial appendage closure?. ### Response: stroke prevention in atrial fibrilla-tion.


Instruction: Atrial fibrilla-tion. 2017;69:253–61. What is the name of the device used for left atrial appendage closure?

Output: WATCHMAN

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atrial fibrilla-tion. 2017;69:253–61. What is the name of the device used for left atrial appendage closure?. ### Response: WATCHMAN.


Instruction: What are the results of the EWOLUTION registry?

Output: peri-procedural outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of the EWOLUTION registry?. ### Response: peri-procedural outcomes.


Instruction: What is the ASA Plavix Feasibility Study With Watchman Left Atrial Appendage Closure Technology?

Output: ASAP study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ASA Plavix Feasibility Study With Watchman Left Atrial Appendage Closure Technology?. ### Response: ASAP study.


Instruction: What is a contraindication for oral anticoagulation?

Output: Left atrial appendage closure with the Watchman device

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a contraindication for oral anticoagulation?. ### Response: Left atrial appendage closure with the Watchman device.


Instruction: How long did the EWOLUTION trial last?

Output: 1-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the EWOLUTION trial last?. ### Response: 1-year.


Instruction: What is the name of the study that evaluated the efficacy and safety of left atrial appendage closure with WATCHMAN in patients with or without contraindication to oral anticoagulation?

Output: EWOLUTION trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated the efficacy and safety of left atrial appendage closure with WATCHMAN in patients with or without contraindication to oral anticoagulation?. ### Response: EWOLUTION trial.


Instruction: What is the name of the study that evaluated the Watchman device in patients unsuitable for oral anticoagulation?

Output: ASAP-TOO

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated the Watchman device in patients unsuitable for oral anticoagulation?. ### Response: ASAP-TOO.


Instruction: What are the results of the AASP-TOO trial?

Output: Implant success and safety

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of the AASP-TOO trial?. ### Response: Implant success and safety.


Instruction: What is an association between left atrial appendage occlusion and readmission for thromboembolism among patients with atrial fibrillation undergoing concomitant car -diac surgery?

Output: Excision S4.4.2-1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an association between left atrial appendage occlusion and readmission for thromboembolism among patients with atrial fibrillation undergoing concomitant car -diac surgery?. ### Response: Excision S4.4.2-1.


Instruction: What is the association between right atrial Appendage closure during cardiac surgery and the occurrence of early postoperative atrial fibrosis?

Output: low intensity of anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association between right atrial Appendage closure during cardiac surgery and the occurrence of early postoperative atrial fibrosis?. ### Response: low intensity of anticoagulation.


Instruction: How many patients underwent cardiac surgery?

Output: 10 633

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients underwent cardiac surgery?. ### Response: 10 633.


Instruction: What was the effect of cardiac surgery on the occurrence of early postoperative atrial fibrillation, stroke, and mortality?

Output: left atrial appendage closure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the effect of cardiac surgery on the occurrence of early postoperative atrial fibrillation, stroke, and mortality?. ### Response: left atrial appendage closure.


Instruction: How many cardiac surgery patients were included in the pro-pensity score-matched analysis of 10 633 patients?

Output: 4.2-1. Friedman DJ, Piccini JP , Wang T, et al. Association between left atrial appendage occlusion and readmission for thromboembolism among patients with atrial fibrillation undergoing concomitant car -diac surgery. JAMA. 2018;319:365–74. S4.4.2-2. Melduni RM, Schaff HV, Lee H-C, et al. Impact of left atrial appendage closure during cardiac surgery on the occurrence of early postoperative atrial fibrillation, stroke, and mortality: a pro-pensity score-matched analysis of 10 633

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many cardiac surgery patients were included in the pro-pensity score-matched analysis of 10 633 patients?. ### Response: 4.2-1. Friedman DJ, Piccini JP , Wang T, et al. Association between left atrial appendage occlusion and readmission for thromboembolism among patients with atrial fibrillation undergoing concomitant car -diac surgery. JAMA. 2018;319:365–74. S4.4.2-2. Melduni RM, Schaff HV, Lee H-C, et al. Impact of left atrial appendage closure during cardiac surgery on the occurrence of early postoperative atrial fibrillation, stroke, and mortality: a pro-pensity score-matched analysis of 10 633.


Instruction: What is associated with low intensity of anticoagulation at the time of cardioversion?

Output: Embolic complica-tions of direct current cardioversion of atrial arrhythmias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with low intensity of anticoagulation at the time of cardioversion?. ### Response: Embolic complica-tions of direct current cardioversion of atrial arrhythmias.


Instruction: What is the J Am Coll Cardiol. 2002;40:926–33?

Output: S6.1.1-2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the J Am Coll Cardiol. 2002;40:926–33?. ### Response: S6.1.1-2.


Instruction: How does anticoagu-lation work?

Output: resolving left atrial and left atrial appendage thrombi

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does anticoagu-lation work?. ### Response: resolving left atrial and left atrial appendage thrombi.


Instruction: What is a transesophageal echocardiographic study?

Output: Efficacy of anticoagu-lation in resolving left atrial and left atrial appendage thrombi

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a transesophageal echocardiographic study?. ### Response: Efficacy of anticoagu-lation in resolving left atrial and left atrial appendage thrombi.


Instruction: What is the name of the 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines?

Output: Antithrombotic therapy for atrial fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines?. ### Response: Antithrombotic therapy for atrial fibrillation.


Instruction: What is limiting our ability to generalize our recommendations to many real-world patients?

Output: other comorbidities from enrollment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is limiting our ability to generalize our recommendations to many real-world patients?. ### Response: other comorbidities from enrollment.