Instruction: How long are door-to-imaging times?

Output: 26 minutes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long are door-to-imaging times?. ### Response: 26 minutes.


Instruction: What is the difference between DTN times and hours?

Output: 78 minutes versus 80 minutes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between DTN times and hours?. ### Response: 78 minutes versus 80 minutes.


Instruction: How long is symptom onset to needle time?

Output: 141 minutes versus 145 minutes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is symptom onset to needle time?. ### Response: 141 minutes versus 145 minutes.


Instruction: What should public health leaders design and implement?

Output: public education programs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should public health leaders design and implement?. ### Response: public education programs.


Instruction: How should public education programs be sustained over time?

Output: designed to reach racially/ethnically, age, and sex diverse populations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How should public education programs be sustained over time?. ### Response: designed to reach racially/ethnically, age, and sex diverse populations.


Instruction: What should be sustained over time?

Output: public education programs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be sustained over time?. ### Response: public education programs.


Instruction: What should these programs be designed to reach?

Output: racially/ethnically, age, and sex diverse populations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should these programs be designed to reach?. ### Response: racially/ethnically, age, and sex diverse populations.


Instruction: When was the Stroke Systems of Care revised?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Stroke Systems of Care revised?. ### Response: 2013.


Instruction: What type of surgery is indicated in asymptomatic patients with severe rheumatic MS?

Output: PMBC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of surgery is indicated in asymptomatic patients with severe rheumatic MS?. ### Response: PMBC.


Instruction: How large is the mitral valve area in Stage C patients?

Output: ≤1.5 cm2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How large is the mitral valve area in Stage C patients?. ### Response: ≤1.5 cm2.


Instruction: What is a reasonable PMBC if it can be performed at a Comprehensive Valve Center?

Output: In asymptomatic patients with severe rheumatic MS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a reasonable PMBC if it can be performed at a Comprehensive Valve Center?. ### Response: In asymptomatic patients with severe rheumatic MS.


Instruction: What is the mitral valve area 1.5 cm2?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the mitral valve area 1.5 cm2?. ### Response: ≤.


Instruction: What type of MS has a mitral valve area 1.5 cm2, Stage C?

Output: severe rheumatic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of MS has a mitral valve area 1.5 cm2, Stage C?. ### Response: severe rheumatic.


Instruction: PMBC may be considered if it can be performed at a Comprehensive Valve Center.

Output: asymptomatic patients with severe rheumatic MS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: PMBC may be considered if it can be performed at a Comprehensive Valve Center.. ### Response: asymptomatic patients with severe rheumatic MS.


Instruction: Where is the Comprehensive Valve Center located?

Output: 142b C-LD4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the Comprehensive Valve Center located?. ### Response: 142b C-LD4.


Instruction: What is the mitral valve area of a symptomatic patient with rheumatic MS?

Output: ≤1.5 cm2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the mitral valve area of a symptomatic patient with rheumatic MS?. ### Response: ≤1.5 cm2.


Instruction: What is the mean mitral valve gradient during exercise?

Output: >15 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the mean mitral valve gradient during exercise?. ### Response: >15 mm Hg.


Instruction: Where can PMBC be performed?

Output: Comprehensive Valve Center

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can PMBC be performed?. ### Response: Comprehensive Valve Center.


Instruction: What type of MS is PMBC considered?

Output: rheumatic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of MS is PMBC considered?. ### Response: rheumatic.


Instruction: What type of MS has a suboptimal valve anatomy?

Output: rheumatic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of MS has a suboptimal valve anatomy?. ### Response: rheumatic.


Instruction: PMBC may be considered if it can be performed at a Comprehensive Valve Center?

Output: asymptomatic patients with severe rheumatic MS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: PMBC may be considered if it can be performed at a Comprehensive Valve Center?. ### Response: asymptomatic patients with severe rheumatic MS.


Instruction: What is the optimal treatment for patients with rheumatic MS?

Output: PMBC or surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the optimal treatment for patients with rheumatic MS?. ### Response: PMBC or surgery.


Instruction: Where can PMBC or surgery be performed?

Output: experienced centers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can PMBC or surgery be performed?. ### Response: experienced centers.


Instruction: What can be performed at a Comprehensive Valve Center?

Output: PMBC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be performed at a Comprehensive Valve Center?. ### Response: PMBC.


Instruction: What type of procedure is used to relieve stenosis?

Output: splitting open fused commissures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of procedure is used to relieve stenosis?. ### Response: splitting open fused commissures.


Instruction: How much has the use of commissurotomy decreased in the U.S.?

Output: 7.5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much has the use of commissurotomy decreased in the U.S.?. ### Response: 7.5%.


Instruction: What is the name of the procedure that involves splitting open fused commissures?

Output: PMBC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the procedure that involves splitting open fused commissures?. ### Response: PMBC.


Instruction: What has been a decrease in the use of PMBC in the US?

Output: 7.5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been a decrease in the use of PMBC in the US?. ### Response: 7.5%.


Instruction: What is the increase in complica-tion rate?

Output: 15.9%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the increase in complica-tion rate?. ### Response: 15.9%.


Instruction: How is commissurotomy performed in the United States?

Output: routinely or widely performed by most surgeons

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is commissurotomy performed in the United States?. ### Response: routinely or widely performed by most surgeons.


Instruction: What is an option for treatment only if there is no other option and the patient has what?

Output: severe limiting symptoms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an option for treatment only if there is no other option and the patient has what?. ### Response: severe limiting symptoms.


Instruction: What is essential in the clinical decision-making process for a patient with rheumatic MS?

Output: know the results of the available interventional procedures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is essential in the clinical decision-making process for a patient with rheumatic MS?. ### Response: know the results of the available interventional procedures.


Instruction: What does PMBC have compared to surgical closed or open commissurotomy in patients with rheumatic MS?

Output: safety and efficacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does PMBC have compared to surgical closed or open commissurotomy in patients with rheumatic MS?. ### Response: safety and efficacy.


Instruction: What type of studies have established the safety and efficacy of PMBC?

Output: Randomized trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of studies have established the safety and efficacy of PMBC?. ### Response: Randomized trials.


Instruction: What type of MS is Intervention for?

Output: Rheumatic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of MS is Intervention for?. ### Response: Rheumatic.


Instruction: When was Intervention for Rheumatic MSDownloaded from http://ahajournals.org

Output: April 27, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Intervention for Rheumatic MSDownloaded from http://ahajournals.org. ### Response: April 27, 2023.


Instruction: What are cations underreported?

Output: anaphylactic re-actions to protamine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are cations underreported?. ### Response: anaphylactic re-actions to protamine.


Instruction: What are true anaphylactic re-actions to protamine?

Output: rare

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are true anaphylactic re-actions to protamine?. ### Response: rare.


Instruction: How many patients have CPB?

Output: less than 1%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients have CPB?. ### Response: less than 1%.


Instruction: What did the limited database of anaphylactic reactions show?

Output: cardiac surgery proceededwithout complications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the limited database of anaphylactic reactions show?. ### Response: cardiac surgery proceededwithout complications.


Instruction: What did cardiac surgery proceed without complications after?

Output: cardiovascular collapsecaused by pre-CPB anaphylactic or anaphylactoid re-actions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did cardiac surgery proceed without complications after?. ### Response: cardiovascular collapsecaused by pre-CPB anaphylactic or anaphylactoid re-actions.


Instruction: What may be the treatment of choice in this setting?

Output: methyleneblue

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be the treatment of choice in this setting?. ### Response: methyleneblue.


Instruction: Evidence to date suggests that the site of protamineadministration does not what?

Output: protamine-induced pulmonary vasoconstriction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Evidence to date suggests that the site of protamineadministration does not what?. ### Response: protamine-induced pulmonary vasoconstriction.


Instruction: What may decrease the incidence of protamine-induced pulmonary vasoconstriction?

Output: aspirin ingestion within 1 week of surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may decrease the incidence of protamine-induced pulmonary vasoconstriction?. ### Response: aspirin ingestion within 1 week of surgery.


Instruction: What often precede catastrophic re-actions toprotamine?

Output: right ventricular failure andpulmonary hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What often precede catastrophic re-actions toprotamine?. ### Response: right ventricular failure andpulmonary hypertension.


Instruction: Which drugs attenuate the acute rightventricular failure andpulmonary hypertension?

Output: Prostacyclin andbradykinin B2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which drugs attenuate the acute rightventricular failure andpulmonary hypertension?. ### Response: Prostacyclin andbradykinin B2.


Instruction: What do prostacyclin andbradykinin B2 attenuate in acute pulmonary hypertension?

Output: the acute pulmonary hyperten-sion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do prostacyclin andbradykinin B2 attenuate in acute pulmonary hypertension?. ### Response: the acute pulmonary hyperten-sion.


Instruction: What do serious protamine reactions predispose to?

Output: operative mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do serious protamine reactions predispose to?. ### Response: operative mortality.


Instruction: What may be lifesaving if serious protoamine reactions occur?

Output: discontinuation of protamineand reinstitution of CPB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be lifesaving if serious protoamine reactions occur?. ### Response: discontinuation of protamineand reinstitution of CPB.


Instruction: Antibodies to what complex occur commonly after CPB?

Output: protamine/heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Antibodies to what complex occur commonly after CPB?. ### Response: protamine/heparin.


Instruction: What is one of the serologic features of HIT-derived antibodies?

Output: platelet activation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the serologic features of HIT-derived antibodies?. ### Response: platelet activation.


Instruction: What does HIT/heparin antibodies cross react with?

Output: protamine-containing insulin preparations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does HIT/heparin antibodies cross react with?. ### Response: protamine-containing insulin preparations.


Instruction: Development of these antibodies predisposes to what after cardiac procedures?

Output: adverseoutcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Development of these antibodies predisposes to what after cardiac procedures?. ### Response: adverseoutcomes.


Instruction: How many times higher was the risk of a protamine reaction in surgicalpatients?

Output: 10 to 20 times

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many times higher was the risk of a protamine reaction in surgicalpatients?. ### Response: 10 to 20 times.


Instruction: What is an alternative agent used to reverse heparin?

Output: protamine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an alternative agent used to reverse heparin?. ### Response: protamine.


Instruction: What affects platelet ag-gregation and whole blood clotting?

Output: Reversal of heparin with protamine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What affects platelet ag-gregation and whole blood clotting?. ### Response: Reversal of heparin with protamine.


Instruction: What makes protamine the drug of choice for heparin neutralization?

Output: The over-whelming convenience of protamine reversal of heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What makes protamine the drug of choice for heparin neutralization?. ### Response: The over-whelming convenience of protamine reversal of heparin.


Instruction: What is PF4 used for?

Output: heparin neutralizationdespite potential adverse effects on platelet and clottingfunction. There are patients who are unable to receiveprotamine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PF4 used for?. ### Response: heparin neutralizationdespite potential adverse effects on platelet and clottingfunction. There are patients who are unable to receiveprotamine.


Instruction: What is the main reason patients are unable to receive protamine?

Output: right ventricular failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the main reason patients are unable to receive protamine?. ### Response: right ventricular failure.


Instruction: What is a summary of the evidence quality in support of there recommendations?

Output: Table 3 ).

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a summary of the evidence quality in support of there recommendations?. ### Response: Table 3 )..


Instruction: What is the strength of a recommendation graded as?

Output: strong or weak

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the strength of a recommendation graded as?. ### Response: strong or weak.


Instruction: The balance of bene fits andharms across all critical and important outcomes determines what?

Output: The strengthof a recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The balance of bene fits andharms across all critical and important outcomes determines what?. ### Response: The strengthof a recommendation.


Instruction: What was the anticipated net health bene fit determined on the basis of?

Output: expected bene ﬁts and harms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the anticipated net health bene fit determined on the basis of?. ### Response: expected bene ﬁts and harms.


Instruction: What did the Work Group and ERT determine?

Output: the anticipated net health bene ﬁt

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Work Group and ERT determine?. ### Response: the anticipated net health bene ﬁt.


Instruction: How did the ERT assist Work Group members in evaluating the balance of bene fits and harms arising from key individualstudies?

Output: evi-dence review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did the ERT assist Work Group members in evaluating the balance of bene fits and harms arising from key individualstudies?. ### Response: evi-dence review.


Instruction: What was the overall quality of the evidence based on?

Output: the certainty of the evidence for all critical andimportant outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the overall quality of the evidence based on?. ### Response: the certainty of the evidence for all critical andimportant outcomes.


Instruction: What was graded A, B, C or D?

Output: overall quality of theevidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was graded A, B, C or D?. ### Response: overall quality of theevidence.


Instruction: What was the overall quality of the evidence graded?

Output: A, B, C, or D

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the overall quality of the evidence graded?. ### Response: A, B, C, or D.


Instruction: What is the GRADE system for grading quality of evidence?

Output: Grading of Recommendations Assessment, Development and Evaluation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the GRADE system for grading quality of evidence?. ### Response: Grading of Recommendations Assessment, Development and Evaluation.


Instruction: What would reduce the demonstrated effect?

Output: All plausible confounding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would reduce the demonstrated effect?. ### Response: All plausible confounding.


Instruction: What would be reduced by plausible confounding?

Output: the demonstrated effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would be reduced by plausible confounding?. ### Response: the demonstrated effect.


Instruction: What does GRADE stand for?

Output: Grading of Recommendations Assessment, Development and Evaluation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does GRADE stand for?. ### Response: Grading of Recommendations Assessment, Development and Evaluation.


Instruction: What is the name of the randomized controlled trial?

Output: RCT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized controlled trial?. ### Response: RCT.


Instruction: What percentage of people in your situation would want the recommended course ofaction?

Output: The majority

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of people in your situation would want the recommended course ofaction?. ### Response: The majority.


Instruction: What should most patients receive?

Output: therecommended course of action

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should most patients receive?. ### Response: therecommended course of action.


Instruction: The recommendation can be evaluated as a candidate for what?

Output: developing a policy or aperformance measure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The recommendation can be evaluated as a candidate for what?. ### Response: developing a policy or aperformance measure.


Instruction: How many people in your situation would want the recommended courseof action?

Output: The majority

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people in your situation would want the recommended courseof action?. ### Response: The majority.


Instruction: What will be appropriate fordifferent patients?

Output: Different choices

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will be appropriate fordifferent patients?. ### Response: Different choices.


Instruction: Each patient needshelp to arrive at a management decision consistent with what?

Output: her or his values andpreferences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Each patient needshelp to arrive at a management decision consistent with what?. ### Response: her or his values andpreferences.


Instruction: The recommendation is likely to require what before policy can be determined?

Output: ubstantial debate and involvement ofstakeholders

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The recommendation is likely to require what before policy can be determined?. ### Response: ubstantial debate and involvement ofstakeholders.


Instruction: What is required before policy can be determined?

Output: ubstantial debate and involvement ofstakeholders

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is required before policy can be determined?. ### Response: ubstantial debate and involvement ofstakeholders.


Instruction: What is the most likely a strong recommendation?

Output: weak

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most likely a strong recommendation?. ### Response: weak.


Instruction: How many studies are there on non-anticoagulated AF patients?

Output: few/no

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies are there on non-anticoagulated AF patients?. ### Response: few/no.


Instruction: What do current studies do not do?

Output: inform whether the biomarkers will discriminate/identify low risk in lower/intermediate risk patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do current studies do not do?. ### Response: inform whether the biomarkers will discriminate/identify low risk in lower/intermediate risk patients.


Instruction: What do current studies do not inform whether the biomarkers will discriminate/identify low risk in lower/intermediate risk patients whoare not anticoagulated?

Output: stroke rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do current studies do not inform whether the biomarkers will discriminate/identify low risk in lower/intermediate risk patients whoare not anticoagulated?. ### Response: stroke rates.


Instruction: Instead of focus on identifying “high risk,” the focus should be on what?

Output: initially identifying “low risk ”patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Instead of focus on identifying “high risk,” the focus should be on what?. ### Response: initially identifying “low risk ”patients.


Instruction: How does the CHA 2DS2-VASc categorize low riskpatients?

Output: consistently identi ﬁes low riskpatients, with event rates around 1% per year or under

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does the CHA 2DS2-VASc categorize low riskpatients?. ### Response: consistently identi ﬁes low riskpatients, with event rates around 1% per year or under.


Instruction: What is the event rate per year or under?

Output: 1%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the event rate per year or under?. ### Response: 1%.


Instruction: The majority of published studies and systematic reviews suggest what?

Output: 65

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The majority of published studies and systematic reviews suggest what?. ### Response: 65.


Instruction: What is the CHA 2DS2-VASc score generally better than?

Output: CHADS 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the CHA 2DS2-VASc score generally better than?. ### Response: CHADS 2.


Instruction: What is CHADS 2score plus age 65-74years used in?

Output: Canadian guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CHADS 2score plus age 65-74years used in?. ### Response: Canadian guidelines.


Instruction: What is the proportion of the population assigned as low risk?

Output: small

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the proportion of the population assigned as low risk?. ### Response: small.


Instruction: What are con flicting data in different cohorts forperformance of the ATRIA score?

Output: United KingdomClinical Practice Research Datalink [UK CPRD] andSwedish cohorts vs Danish and Taiwan cohorts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are con flicting data in different cohorts forperformance of the ATRIA score?. ### Response: United KingdomClinical Practice Research Datalink [UK CPRD] andSwedish cohorts vs Danish and Taiwan cohorts.


Instruction: When cut-points are optimized for stroke risk, differences between ATRIA and CHA 2DS2-VASc disappear?

Output: 2-VASc

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When cut-points are optimized for stroke risk, differences between ATRIA and CHA 2DS2-VASc disappear?. ### Response: 2-VASc.


Instruction: CHA 2DS2-VAScdisappear when cut-points are optimized for what?

Output: stroke risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: CHA 2DS2-VAScdisappear when cut-points are optimized for what?. ### Response: stroke risk.


Instruction: There are discrepancies between individualstudies on the relative performance of ATRIA and what else?

Output: CHA2DS2-VASc scores

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There are discrepancies between individualstudies on the relative performance of ATRIA and what else?. ### Response: CHA2DS2-VASc scores.


Instruction: What is easier to calculate?

Output: CHA 2DS2-VASc score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is easier to calculate?. ### Response: CHA 2DS2-VASc score.


Instruction: How did we categorize risk scores?

Output: categorical manner

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did we categorize risk scores?. ### Response: categorical manner.


Instruction: What is the wide variation in reported event rates based on?

Output: reported study clinical setting, patient population,ethnicity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the wide variation in reported event rates based on?. ### Response: reported study clinical setting, patient population,ethnicity.


Instruction: What should be the default for all AF patients unless deemed to be low risk?

Output: bestroke prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be the default for all AF patients unless deemed to be low risk?. ### Response: bestroke prevention.


Instruction: What should the focus be on initiallyidentifying low risk patients who do not needantithrombotic therapy?

Output: use scores

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should the focus be on initiallyidentifying low risk patients who do not needantithrombotic therapy?. ### Response: use scores.


Instruction: Prior guidelines have also opted for the CHA2DS2-VASc score to de fine a low risk group?

Output: low riskpatients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Prior guidelines have also opted for the CHA2DS2-VASc score to de fine a low risk group?. ### Response: low riskpatients.


Instruction: What refers to recentcompensated HF regardless of the ejection fraction?

Output: CHA 2DS2-VASc

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What refers to recentcompensated HF regardless of the ejection fraction?. ### Response: CHA 2DS2-VASc.


Instruction: What is the term for a history of hypertension or uncontrolled BP?

Output: H

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for a history of hypertension or uncontrolled BP?. ### Response: H.


Instruction: What is another term for stroke, systemic?

Output: ‘S

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for stroke, systemic?. ### Response: ‘S.


Instruction: What should the medical profession play a central role in evaluating the evidence related to drugs, devices, and procedures?

Output: detection, management, and prevention of disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should the medical profession play a central role in evaluating the evidence related to drugs, devices, and procedures?. ### Response: detection, management, and prevention of disease.


Instruction: What should expert analysis of available data on the benefits and disadvantages of drugs and devices do?

Output: write guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should expert analysis of available data on the benefits and disadvantages of drugs and devices do?. ### Response: write guidelines.


Instruction: What can an organized and directed approach to athorough review of evidence have resulted in the production of?

Output: clinical practice guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can an organized and directed approach to athorough review of evidence have resulted in the production of?. ### Response: clinical practice guidelines.


Instruction: What can properly applied, expert analysis of available data on the benefits and risks of therapies and procedures do?

Output: improve the quality of care, optimize patient outcomes, andfavorably affect costs by focusing resources on the mosteffective strategies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can properly applied, expert analysis of available data on the benefits and risks of therapies and procedures do?. ### Response: improve the quality of care, optimize patient outcomes, andfavorably affect costs by focusing resources on the mosteffective strategies.


Instruction: What has resulted in the production ofclinical practice guidelines?

Output: orough review of evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has resulted in the production ofclinical practice guidelines?. ### Response: orough review of evidence.


Instruction: What can clinical practice guidelines provide a founda-tion for other applications?

Output: performance measures,appropriate use criteria, and both quality improvement andclinical decision support tools

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can clinical practice guidelines provide a founda-tion for other applications?. ### Response: performance measures,appropriate use criteria, and both quality improvement andclinical decision support tools.


Instruction: What is the acronym for the American College of Cardiology Foundation?

Output: ACCF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the American College of Cardiology Foundation?. ### Response: ACCF.


Instruction: What are the names of the organizations that have jointly produced guidelines in the area of cardiovascular disease since 1980?

Output: The American College of Cardiology Foundation (ACCF)and the American Heart Association (AHA)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the organizations that have jointly produced guidelines in the area of cardiovascular disease since 1980?. ### Response: The American College of Cardiology Foundation (ACCF)and the American Heart Association (AHA).


Instruction: Who is charged with developing, updating and revising practice guidelines for cardiovascular diseases and procedures?

Output: The ACCF/AHA Task Force on Practice Guide-lines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is charged with developing, updating and revising practice guidelines for cardiovascular diseases and procedures?. ### Response: The ACCF/AHA Task Force on Practice Guide-lines.


Instruction: What are writing commit-tees charged with regularly reviewing and evaluating all available evidence?

Output: to develop balanced, patient-centric rec-ommendations for clinical practice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are writing commit-tees charged with regularly reviewing and evaluating all available evidence?. ### Response: to develop balanced, patient-centric rec-ommendations for clinical practice.


Instruction: Who selects experts in the subject under consideration to examine subject-specific data and write guidelines?

Output: the ACCF and AHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who selects experts in the subject under consideration to examine subject-specific data and write guidelines?. ### Response: the ACCF and AHA.


Instruction: Who examines subject-specific data andwrites guidelines in partnership with representatives from other medical organizations and specialty groups?

Output: the ACCF and AHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who examines subject-specific data andwrites guidelines in partnership with representatives from other medical organizations and specialty groups?. ### Response: the ACCF and AHA.


Instruction: Who performs a formal literature review?

Output: Writingcommittees

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who performs a formal literature review?. ### Response: Writingcommittees.


Instruction: What are writingcommittees asked to do?

Output: perform a formal literature review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are writingcommittees asked to do?. ### Response: perform a formal literature review.


Instruction: What is included where such data exist?

Output: estimates of expectedoutcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is included where such data exist?. ### Response: estimates of expectedoutcomes.


Instruction: What are patient-specific modifiers,comorbidities, and issues of patient preference that may be included?

Output: 576

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patient-specific modifiers,comorbidities, and issues of patient preference that may be included?. ### Response: 576.


Instruction: What is the name of the study that investigated decompressive hemi-craniectomy without clot evacuation in dominant-sided intracere-bral hemorrhage with ICP crisis?

Output: Neurosurg Focus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated decompressive hemi-craniectomy without clot evacuation in dominant-sided intracere-bral hemorrhage with ICP crisis?. ### Response: Neurosurg Focus.


Instruction: What does Focus. 2013:34:E5 do?

Output: Decompressive hemi-craniectomy without clot evacuation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Focus. 2013:34:E5 do?. ### Response: Decompressive hemi-craniectomy without clot evacuation.


Instruction: Who is the author of Focus?

Output: Mendelow

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of Focus?. ### Response: Mendelow.


Instruction: What is the name of the randomised trial that evaluated early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas?

Output: International Surgical Trial in Intracerebral Haemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised trial that evaluated early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas?. ### Response: International Surgical Trial in Intracerebral Haemorrhage.


Instruction: What is STICH?

Output: Surgical Trial in Lobar Intracerebral Haemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is STICH?. ### Response: Surgical Trial in Lobar Intracerebral Haemorrhage.


Instruction: What is the name of the randomised trial in Intracerebral Haemorrhage?

Output: International Surgical Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised trial in Intracerebral Haemorrhage?. ### Response: International Surgical Trial.


Instruction: How many patients were involved in the STICH trial?

Output: 237

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were involved in the STICH trial?. ### Response: 237.


Instruction: How many cases of spontaneous posterior fossa haematomas were studied?

Output: 205

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many cases of spontaneous posterior fossa haematomas were studied?. ### Response: 205.


Instruction: What was the outcome of the study?

Output: randomised trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome of the study?. ### Response: randomised trial.


Instruction: How many patients were treated with surgical versus medical treatment?

Output: 205

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with surgical versus medical treatment?. ### Response: 205.


Instruction: How many cases of spontaneous cerebellar haemorrhage were reviewed in a series?

Output: 49

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many cases of spontaneous cerebellar haemorrhage were reviewed in a series?. ### Response: 49.


Instruction: What is the name of the journal that reviews the management of spontaneous cerebral haemopoeia?

Output: Lancet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that reviews the management of spontaneous cerebral haemopoeia?. ### Response: Lancet.


Instruction: When did Acta Neurochir issue 122?

Output: 1993

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Acta Neurochir issue 122?. ### Response: 1993.


Instruction: What is the difference between craniotomy and decompres-sive craniectomy for surgical evacuation of nontraumatic, supratentorial intracerebral hemorrhage?

Output: Retrospective comparison

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between craniotomy and decompres-sive craniectomy for surgical evacuation of nontraumatic, supratentorial intracerebral hemorrhage?. ### Response: Retrospective comparison.


Instruction: What does rtPA do?

Output: intracerebral hemorrhage evacuation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does rtPA do?. ### Response: intracerebral hemorrhage evacuation.


Instruction: What is MISTIE?

Output: minimally-invasive surgery plus rtPA for intracerebral hemorrhage evacuation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is MISTIE?. ### Response: minimally-invasive surgery plus rtPA for intracerebral hemorrhage evacuation.


Instruction: What is the name of the clinical trial?

Output: MISTIE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the clinical trial?. ### Response: MISTIE.


Instruction: When was the acta neurochir Suppl. 2008?

Output: 105:147–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the acta neurochir Suppl. 2008?. ### Response: 105:147–.


Instruction: What is the difference between endoscopic surgery and medical treatment for spontaneous intrace-rebral hematoma?

Output: Early surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between endoscopic surgery and medical treatment for spontaneous intrace-rebral hematoma?. ### Response: Early surgery.


Instruction: When was the J Neurosurg. 1989.70:530–535. doi: 10.3171/jns.1989.70.4.0530?

Output: 1989

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Neurosurg. 1989.70:530–535. doi: 10.3171/jns.1989.70.4.0530?. ### Response: 1989.


Instruction: What is the difference between endoscopic surgery and craniotomy in noncomatose patients?

Output: stereotactic aspiration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between endoscopic surgery and craniotomy in noncomatose patients?. ### Response: stereotactic aspiration.


Instruction: What is a meta-analysis of randomized controlled trials?

Output: Minimally Invasive Surgery for Spontaneous Supratentorial Intracerebral Hemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a meta-analysis of randomized controlled trials?. ### Response: Minimally Invasive Surgery for Spontaneous Supratentorial Intracerebral Hemorrhage.


Instruction: Who wrote a letter to the editor regarding article on minimally invasive surgery?

Output: Gregson et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote a letter to the editor regarding article on minimally invasive surgery?. ### Response: Gregson et al.


Instruction: What is the name of the study that investigated randomized controlled trials?

Output: STICH II

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated randomized controlled trials?. ### Response: STICH II.


Instruction: What was the title of this study?

Output: Minimally Invasive Surgery for Spontaneous Supratentorial Intracerebral Hemorrhage: A Meta-Analysis of Randomized Controlled Trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the title of this study?. ### Response: Minimally Invasive Surgery for Spontaneous Supratentorial Intracerebral Hemorrhage: A Meta-Analysis of Randomized Controlled Trials.


Instruction: When was Stroke released?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Stroke released?. ### Response: 2013.


Instruction: Publishers, editorial board, and ISN make every effort to make sure that no inaccurate or misleading data, opinionor statement appears in what Journal?

Output: this Journal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Publishers, editorial board, and ISN make every effort to make sure that no inaccurate or misleading data, opinionor statement appears in what Journal?. ### Response: this Journal.


Instruction: What is the responsibility of the contributor, copyright holder or advertiser?

Output: the data and opinions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the responsibility of the contributor, copyright holder or advertiser?. ### Response: the data and opinions.


Instruction: What is the responsibility of the contributor, copyright holder, or advertiser concerned?

Output: the data and opinions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the responsibility of the contributor, copyright holder, or advertiser concerned?. ### Response: the data and opinions.


Instruction: Who accepts no liability whatsoever for the consequences of inaccurate or misleading data,opinion or statement?

Output: thepublishers and the ISN, the editorial board and their respectiveemployers, ofﬁce and agents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who accepts no liability whatsoever for the consequences of inaccurate or misleading data,opinion or statement?. ### Response: thepublishers and the ISN, the editorial board and their respectiveemployers, ofﬁce and agents.


Instruction: What should new methods and techniquesinvolving drug usage only be followed in conjunction with?

Output: the drugmanufacturer’s own published literature

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should new methods and techniquesinvolving drug usage only be followed in conjunction with?. ### Response: the drugmanufacturer’s own published literature.


Instruction: What is the age restriction in all RCTs for DM?

Output: Supplementary Table 65

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the age restriction in all RCTs for DM?. ### Response: Supplementary Table 65.


Instruction: What is the age restriction in all RCTs for DM CKD?

Output: Supplementary Table 65

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the age restriction in all RCTs for DM CKD?. ### Response: Supplementary Table 65.


Instruction: What are the PICO criteria for blood pressure targets inelderly studies?

Output: Age restriction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the PICO criteria for blood pressure targets inelderly studies?. ### Response: Age restriction.


Instruction: What is CKD in elderly people the same condition as in young adults?

Output: age-related mechanisms such as fibrosis and cellularsenescence interact with mechanisms underlying CKD progression

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CKD in elderly people the same condition as in young adults?. ### Response: age-related mechanisms such as fibrosis and cellularsenescence interact with mechanisms underlying CKD progression.


Instruction: What do age-related mechanisms such as fibrosis and cellularsenescence interact with?

Output: mechanisms underlying CKD progression

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do age-related mechanisms such as fibrosis and cellularsenescence interact with?. ### Response: mechanisms underlying CKD progression.


Instruction: How do fibrosis and cellularsenescence interact with mechanisms underlying CKD progression?

Output: age-related mechanisms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do fibrosis and cellularsenescence interact with mechanisms underlying CKD progression?. ### Response: age-related mechanisms.


Instruction: What determines the risk for progression of kidney disease?

Output: age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What determines the risk for progression of kidney disease?. ### Response: age.


Instruction: How does age-associated changes in vascular biology differ from other parenchymal kidney disease changes?

Output: Age restriction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does age-associated changes in vascular biology differ from other parenchymal kidney disease changes?. ### Response: Age restriction.


Instruction: What are the morphologic correlates of CKD in elderly people?

Output: age-related mechanisms such as fibrosis and cellularsenescence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the morphologic correlates of CKD in elderly people?. ### Response: age-related mechanisms such as fibrosis and cellularsenescence.


Instruction: What are other markers that can contribute to the assessment of the prognosis of elderly people, beyond GFR and cystatin?

Output: morphologic correlates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are other markers that can contribute to the assessment of the prognosis of elderly people, beyond GFR and cystatin?. ### Response: morphologic correlates.


Instruction: How do age-related changes in vascular biology contribute to CKD-associated increases in cardiovascular risk?

Output: CVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do age-related changes in vascular biology contribute to CKD-associated increases in cardiovascular risk?. ### Response: CVD.


Instruction: What are the age related changes in non-traditional cardiovascular riskfactors?

Output: Age restriction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the age related changes in non-traditional cardiovascular riskfactors?. ### Response: Age restriction.


Instruction: How do comorbidities differ during the transition to kidney failure?

Output: Age restriction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do comorbidities differ during the transition to kidney failure?. ### Response: Age restriction.


Instruction: What type of intervention can prevent the deterioration in physical functioning and frailty inpatients with CKD?

Output: physical activity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of intervention can prevent the deterioration in physical functioning and frailty inpatients with CKD?. ### Response: physical activity.


Instruction: How does age interact with exercise in prevention or reduction ofcomorbidities associated with progression?

Output: restriction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does age interact with exercise in prevention or reduction ofcomorbidities associated with progression?. ### Response: restriction.


Instruction: What year was the ACCF/AHA focused update incorporated into the 2007 guidelines for the man-agement of patients with unstable angina/non-ST-elevation myocardial infarction?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the ACCF/AHA focused update incorporated into the 2007 guidelines for the man-agement of patients with unstable angina/non-ST-elevation myocardial infarction?. ### Response: 2012.


Instruction: What is the acronym for Cardiology Foundation/American Heart Association Task Force on Practice Guidelines?

Output: American College

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Cardiology Foundation/American Heart Association Task Force on Practice Guidelines?. ### Response: American College.


Instruction: When was Circulation 2013 published?

Output: 127:e663–828

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Circulation 2013 published?. ### Response: 127:e663–828.


Instruction: What was the name of the meta-analysis with 5-year patient-level data from ARTS?

Output: Long-term safety and efficacy of percutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the meta-analysis with 5-year patient-level data from ARTS?. ### Response: Long-term safety and efficacy of percutaneous coronary intervention.


Instruction: How long did the meta-analysis include data from the ARTS, ERACI, MASS-II, and SoS trials?

Output: 5-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the meta-analysis include data from the ARTS, ERACI, MASS-II, and SoS trials?. ### Response: 5-year.


Instruction: Circulation. 2008;118:1146–54.

Output: 93

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation. 2008;118:1146–54.. ### Response: 93.


Instruction: What is the difference between coronary artery bypass surgery and percutaneous coronary interventions for multives-sel disease?

Output: diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between coronary artery bypass surgery and percutaneous coronary interventions for multives-sel disease?. ### Response: diabetes.


Instruction: How many randomised trials were there in 2009?

Output: ten

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many randomised trials were there in 2009?. ### Response: ten.


Instruction: What is the name of the meta-analysis of randomised controlled trials?

Output: The Lancet Diabetes & Endocrinology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis of randomised controlled trials?. ### Response: The Lancet Diabetes & Endocrinology.


Instruction: What is the title of the 2013 issue of Endocrinology?

Output: The Lancet Diabetes & Endocrinology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of the 2013 issue of Endocrinology?. ### Response: The Lancet Diabetes & Endocrinology.


Instruction: What are the key words in the AHA Scientific Statements?

Output: ◼ cardiac catheterization ◼ cardiovascular ◼ chelation therapy ◼ coronary angiography ◼ coronary artery bypass ◼ counterpulsation ◼ diagnostic techniques ◼ focused update ◼ myocardial ischemia ◼ percutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the key words in the AHA Scientific Statements?. ### Response: ◼ cardiac catheterization ◼ cardiovascular ◼ chelation therapy ◼ coronary angiography ◼ coronary artery bypass ◼ counterpulsation ◼ diagnostic techniques ◼ focused update ◼ myocardial ischemia ◼ percutaneous coronary intervention.


Instruction: On what date will AHA Journals be available?

Output: May 1, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On what date will AHA Journals be available?. ### Response: May 1, 2023.


Instruction: Who has an NIH grant related to physical activity?

Output: Dr. Braun

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who has an NIH grant related to physical activity?. ### Response: Dr. Braun.


Instruction: How old is Dr. Braun?

Output: 4/28/23, 4:25 PM Stroke Prevention in W omen: From Young Adulthood to Older Age - Professional Heart Daily | American Heart Associationhttps://professional.heart.org/en/science-news/guidelines-for-the-prevention-of-stroke-in-women/Commentary 1/3ADVERTISEMENTStroke Prevention in Women: From Young Adulthood to Older AgeLast Updated: June 13, 2022

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old is Dr. Braun?. ### Response: 4/28/23, 4:25 PM Stroke Prevention in W omen: From Young Adulthood to Older Age - Professional Heart Daily | American Heart Associationhttps://professional.heart.org/en/science-news/guidelines-for-the-prevention-of-stroke-in-women/Commentary 1/3ADVERTISEMENTStroke Prevention in Women: From Young Adulthood to Older AgeLast Updated: June 13, 2022.


Instruction: Who is on the Speaker’s Bureau for Practice Point?

Output: Dr. Braun

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is on the Speaker’s Bureau for Practice Point?. ### Response: Dr. Braun.


Instruction: Who serves on the Advisory Boards for Up-To-date and Sano?

Output: Dr. Braun

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who serves on the Advisory Boards for Up-To-date and Sano?. ### Response: Dr. Braun.


Instruction: How did GPs feel about the diagnosis and identification of heart failure patients?

Output: a need for education

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did GPs feel about the diagnosis and identification of heart failure patients?. ### Response: a need for education.


Instruction: What was the need for education around the identification and diagnosis of patients with heart failure?

Output: GPs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the need for education around the identification and diagnosis of patients with heart failure?. ### Response: GPs.


Instruction: Who felt that “changes needed to be made within the health profession first”?

Output: GPs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who felt that “changes needed to be made within the health profession first”?. ### Response: GPs.


Instruction: What can be more clearly communicated to patients?

Output: identification and diagnosis of heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be more clearly communicated to patients?. ### Response: identification and diagnosis of heart failure.


Instruction: What did Barnes 2006 recommend?

Output: mutual education

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Barnes 2006 recommend?. ### Response: mutual education.


Instruction: What did cardiology and palliative care staff report a lack of?

Output: clarity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did cardiology and palliative care staff report a lack of?. ### Response: clarity.


Instruction: What should management follow for the predominant lesion?

Output: the guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should management follow for the predominant lesion?. ### Response: the guidelines.


Instruction: What makes patient management difficult?

Output: mixed pathophysiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What makes patient management difficult?. ### Response: mixed pathophysiology.


Instruction: What stage is Mixed valve disease primarily attributable to?

Output: rheumatic disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What stage is Mixed valve disease primarily attributable to?. ### Response: rheumatic disease.


Instruction: What is more frequently seen with degenerative disease or after prior chest radiation?

Output: Mixed valve disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more frequently seen with degenerative disease or after prior chest radiation?. ### Response: Mixed valve disease.


Instruction: What is often seen with degenerative disease or after prior chest radiation?

Output: Mixed valve disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is often seen with degenerative disease or after prior chest radiation?. ### Response: Mixed valve disease.


Instruction: What may require referral to or con-sultation with a Comprehensive Valve Center?

Output: Decision-making for patients with mixed valve disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may require referral to or con-sultation with a Comprehensive Valve Center?. ### Response: Decision-making for patients with mixed valve disease.


Instruction: The complex nature of mixed valve disease requires a comprehensive imaging approach that involves what?

Output: all available data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The complex nature of mixed valve disease requires a comprehensive imaging approach that involves what?. ### Response: all available data.


Instruction: What is the standard modality for measuring jet velocities, valve areas, and regurgitant flow?

Output: TTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the standard modality for measuring jet velocities, valve areas, and regurgitant flow?. ### Response: TTE.


Instruction: What does TTE establish the baseline for?

Output: pathoanatomy and pathophysiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does TTE establish the baseline for?. ### Response: pathoanatomy and pathophysiology.


Instruction: What establishes the baseline for pathoanatomy and pathophysiology?

Output: TTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What establishes the baseline for pathoanatomy and pathophysiology?. ### Response: TTE.


Instruction: Doppler hemodynamics have been validated for patients with single-valve disease but have not necessarily been studied in patients with multivalve diseases?

Output: Doppler hemodynamics have been validated for patients with single-valve disease but have not necessarily been studied in patients with multivalve disease. Limitations exist for assessment of calculations, such as those for valve areas, because of differen-tial flows with multivalve disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Doppler hemodynamics have been validated for patients with single-valve disease but have not necessarily been studied in patients with multivalve diseases?. ### Response: Doppler hemodynamics have been validated for patients with single-valve disease but have not necessarily been studied in patients with multivalve disease. Limitations exist for assessment of calculations, such as those for valve areas, because of differen-tial flows with multivalve disease.


Instruction: What limitations exist for assessment of calculations?

Output: valve areas

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What limitations exist for assessment of calculations?. ### Response: valve areas.


Instruction: What makes it necessary to consider all available data to reach a final management decision?

Output: The complex nature of mixed valve disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What makes it necessary to consider all available data to reach a final management decision?. ### Response: The complex nature of mixed valve disease.


Instruction: What is lacking for many types of mixed valve disease?

Output: natural history data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is lacking for many types of mixed valve disease?. ### Response: natural history data.


Instruction: What is reasonable to assume that the onset of symptoms is a neg-ative prognostic occurrence as it is for all other valve lesions?

Output: natural history data for many types of mixed valve disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable to assume that the onset of symptoms is a neg-ative prognostic occurrence as it is for all other valve lesions?. ### Response: natural history data for many types of mixed valve disease.


Instruction: What type of disease is the cause of the patient’s symptoms?

Output: car -diac disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of disease is the cause of the patient’s symptoms?. ### Response: car -diac disease.


Instruction: Elevated BNP and elevated filling pressures at catheterization support that what?

Output: car -diac disease is the cause of the patient’s symp-toms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Elevated BNP and elevated filling pressures at catheterization support that what?. ### Response: car -diac disease is the cause of the patient’s symp-toms.


Instruction: What is the cause of the patient’s symp-toms?

Output: car -diac disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cause of the patient’s symp-toms?. ### Response: car -diac disease.


Instruction: What may help to further quantify lesion severity?

Output: Elevated BNP and elevated filling pressures at catheterization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may help to further quantify lesion severity?. ### Response: Elevated BNP and elevated filling pressures at catheterization.


Instruction: What is ischemic stroke treated with intravenous thrombolysis?

Output: Get With the Guidelines-Stroke registry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ischemic stroke treated with intravenous thrombolysis?. ### Response: Get With the Guidelines-Stroke registry.


Instruction: What was a retrospective analysis of the Get With the Guidelines-Stroke registry?

Output: ischemic stroke treated with intravenous thrombolysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a retrospective analysis of the Get With the Guidelines-Stroke registry?. ### Response: ischemic stroke treated with intravenous thrombolysis.


Instruction: When was the JAMA Neurol.72:423–431.

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the JAMA Neurol.72:423–431.. ### Response: 2015.


Instruction: What is the doi: 10.1001/jamaneurol.2014.4354?

Output: JAMA Neurol. 2015;72:423–431. doi: 10.1001/jamaneurol.2014.4354 168

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the doi: 10.1001/jamaneurol.2014.4354?. ### Response: JAMA Neurol. 2015;72:423–431. doi: 10.1001/jamaneurol.2014.4354 168.


Instruction: What is the difference between alteplase and aspirin in stroke patients?

Output: functional outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between alteplase and aspirin in stroke patients?. ### Response: functional outcome.


Instruction: What was the outcome of the PRISMS randomized clinical trial?

Output: Early administra-tion of aspirin in patients treated with alteplase for acute ischaemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome of the PRISMS randomized clinical trial?. ### Response: Early administra-tion of aspirin in patients treated with alteplase for acute ischaemic stroke.


Instruction: When was the JAMA 320?

Output: 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the JAMA 320?. ### Response: 2018.


Instruction: What type of disease has no impact on the safety or outcome of lytic therapy in acute ischemic stroke?

Output: Coexistent sickle cell disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of disease has no impact on the safety or outcome of lytic therapy in acute ischemic stroke?. ### Response: Coexistent sickle cell disease.


Instruction: What is the name of the study that found that coexistent sickle cell disease does not have an impact on safety?

Output: Get With The Guidelines–Stroke. Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that found that coexistent sickle cell disease does not have an impact on safety?. ### Response: Get With The Guidelines–Stroke. Stroke.


Instruction: How many strokes were there in 2017?

Output: 686–691. doi: 10.1161/STROKEAHA.116.015412 170

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes were there in 2017?. ### Response: 686–691. doi: 10.1161/STROKEAHA.116.015412 170.


Instruction: What type of activator is beneficial in patients with hyperdense artery sign?

Output: IV tissue plasminogen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of activator is beneficial in patients with hyperdense artery sign?. ### Response: IV tissue plasminogen.


Instruction: When was Neurology 66:1171-1174?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Neurology 66:1171-1174?. ### Response: 2006.


Instruction: What was the name of the third international stroke trial?

Output: IST-3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the third international stroke trial?. ### Response: IST-3.


Instruction: What is IST-3?

Output: third International Stroke Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is IST-3?. ### Response: third International Stroke Trial.


Instruction: How many people were involved in the third IST-3)?

Output: 172

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were involved in the third IST-3)?. ### Response: 172.


Instruction: When was the third International Stroke Trial conducted?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the third International Stroke Trial conducted?. ### Response: 2015.


Instruction: What was the effect of alteplase on the CT hyperdense artery sign and out-come after ischemic stroke?

Output: 118–125

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the effect of alteplase on the CT hyperdense artery sign and out-come after ischemic stroke?. ### Response: 118–125.


Instruction: What is the name of the investigators for CLEAR-ER, IMS III, and ALIAS Part 2?

Output: Adeoye O, Sucharew H, Khoury J, Tomsick T, Khatri P, Palesch Y , Schmit PA, Pancioli AM, Broderick JP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the investigators for CLEAR-ER, IMS III, and ALIAS Part 2?. ### Response: Adeoye O, Sucharew H, Khoury J, Tomsick T, Khatri P, Palesch Y , Schmit PA, Pancioli AM, Broderick JP.


Instruction: What does recombinant tissue-type plasminogen activator plus eptifibatide do?

Output: lysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does recombinant tissue-type plasminogen activator plus eptifibatide do?. ### Response: lysis.


Instruction: What does tissue-type plasminogen activator alone do in acute ischemic stroke?

Output: propen-sity score-matched post hoc analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does tissue-type plasminogen activator alone do in acute ischemic stroke?. ### Response: propen-sity score-matched post hoc analysis.


Instruction: What is the doi: 10.1161/STROKEAHA.114.006743 174?

Output: Recombinant tissue-type plasminogen activator plus eptifibatide versus recombinant tissue-type plasminogen activator alone in acute ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the doi: 10.1161/STROKEAHA.114.006743 174?. ### Response: Recombinant tissue-type plasminogen activator plus eptifibatide versus recombinant tissue-type plasminogen activator alone in acute ischemic stroke.


Instruction: How does a combined approach to lysis work?

Output: eptifibatide and recombinant tissue-type plasminogen ac-tivator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does a combined approach to lysis work?. ### Response: eptifibatide and recombinant tissue-type plasminogen ac-tivator.


Instruction: What is a combination of eptifibatide and recombinant tissue-type plasminogen ac-tivator in acute ischemic stroke?

Output: approach to lysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a combination of eptifibatide and recombinant tissue-type plasminogen ac-tivator in acute ischemic stroke?. ### Response: approach to lysis.


Instruction: What is the name of the full dose regime stroke trial?

Output: Full Dose Regimen Stroke Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the full dose regime stroke trial?. ### Response: Full Dose Regimen Stroke Trial.


Instruction: How many patients were treated with alteplase in 2012?

Output: 176

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with alteplase in 2012?. ### Response: 176.


Instruction: What is the name of the randomised controlled trial for acute ischaemic stroke?

Output: PRISMS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised controlled trial for acute ischaemic stroke?. ### Response: PRISMS.


Instruction: When did Lancet 380:731-737 appear?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Lancet 380:731-737 appear?. ### Response: 2012.


Instruction: What is NICE 2018's acronym for Chronic Heart Failure?

Output: Chronic Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE 2018's acronym for Chronic Heart Failure?. ### Response: Chronic Heart Failure.


Instruction: What is the acronym for Quality of the evidence?

Output: GRADE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Quality of the evidence?. ### Response: GRADE.


Instruction: What is GRADE?

Output: Quality of the evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is GRADE?. ### Response: Quality of the evidence.


Instruction: What is the CI for Anticipated absolute effects Risk with primary care Risk difference with MDTc (95% CI) 3 months (4.95 to 25.77)

Output: 95%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the CI for Anticipated absolute effects Risk with primary care Risk difference with MDTc (95% CI) 3 months (4.95 to 25.77). ### Response: 95%.


Instruction: How many increments as the confidence interval crosses both MID and 1 MID?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many increments as the confidence interval crosses both MID and 1 MID?. ### Response: 2.


Instruction: How many studies were identified in the High risk, Short, Nurse-led or pharmacist-led clinic category?

Output: No

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were identified in the High risk, Short, Nurse-led or pharmacist-led clinic category?. ### Response: No.


Instruction: How many studies were identified in the High risk, Short, Case -management category?

Output: No

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were identified in the High risk, Short, Case -management category?. ### Response: No.


Instruction: What was the highest risk, Mid -length, Home -based MDT?

Output: 9.2.3.1.5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the highest risk, Mid -length, Home -based MDT?. ### Response: 9.2.3.1.5.


Instruction: What is the difference between MDT and Primary +/- secondary care for high risk HF Outcomes No of Participants (studies) Follow up Quality of the evidence (GRADE) Relative effect (95% CI) Anticipated absolute effects Risk with primary +/+ secondary care Risk difference with what type of care?

Output: primary +/ - secondary care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between MDT and Primary +/- secondary care for high risk HF Outcomes No of Participants (studies) Follow up Quality of the evidence (GRADE) Relative effect (95% CI) Anticipated absolute effects Risk with primary +/+ secondary care Risk difference with what type of care?. ### Response: primary +/ - secondary care.


Instruction: What is the risk difference with MDThome (95% CI) Hospitalisations 72 (1 study)  HIGH rate ratio 0.28 (0.16 to 1472 per 1000 1060 fewer per 1000)

Output: Risk with primary +/ - secondary care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk difference with MDThome (95% CI) Hospitalisations 72 (1 study)  HIGH rate ratio 0.28 (0.16 to 1472 per 1000 1060 fewer per 1000). ### Response: Risk with primary +/ - secondary care.


Instruction: What type of AMI patients have substantial risk for future cardiovascular events?

Output: AMI patients who survive the initial event

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of AMI patients have substantial risk for future cardiovascular events?. ### Response: AMI patients who survive the initial event.


Instruction: What was the combined cardiovascular endpoint (vascular death, MI, or stroke) in the PLATO trial?

Output: 11.7%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the combined cardiovascular endpoint (vascular death, MI, or stroke) in the PLATO trial?. ### Response: 11.7%.


Instruction: What was the rate of death, MI, or stroke among AMI patients treated with aspirin and clopidogrel at 12 months?

Output: 11.7%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the rate of death, MI, or stroke among AMI patients treated with aspirin and clopidogrel at 12 months?. ### Response: 11.7%.


Instruction: How many inpatient hospital discharges were attributed to AMI in 2010?

Output: 595 000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many inpatient hospital discharges were attributed to AMI in 2010?. ### Response: 595 000.


Instruction: What is associated with a substantial direct and indirect impact of AMI?

Output: cost burden

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with a substantial direct and indirect impact of AMI?. ### Response: cost burden.


Instruction: What is associated with a substantial direct and indirect cost burden?

Output: AMI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with a substantial direct and indirect cost burden?. ### Response: AMI.


Instruction: What is AMI classified among the top 10 most expensive hospital principal discharge diagnoses?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is AMI classified among the top 10 most expensive hospital principal discharge diagnoses?. ### Response: 3.


Instruction: When was the Third Universal Definition of Myocardial Infarction consensus document published?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Third Universal Definition of Myocardial Infarction consensus document published?. ### Response: 2012.


Instruction: What is defined by the detection of a rise and fall of cardiac biomarkers with at least 1 value above the 99th percentile upper reference limit?

Output: AMI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is defined by the detection of a rise and fall of cardiac biomarkers with at least 1 value above the 99th percentile upper reference limit?. ### Response: AMI.


Instruction: What is preferably cardiac troponin levels?

Output: cardiac biomarkers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is preferably cardiac troponin levels?. ### Response: cardiac biomarkers.


Instruction: What is the ECG?

Output: electrocardiogram

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ECG?. ### Response: electrocardiogram.


Instruction: What is an intracoronary thrombus identified by angiography?

Output: autopsy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an intracoronary thrombus identified by angiography?. ### Response: autopsy.


Instruction: When was the Third Universal Definition of Myocardial Infarction consen-sus published?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Third Universal Definition of Myocardial Infarction consen-sus published?. ### Response: 2012.


Instruction: How many types of MI are classified?

Output: 5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many types of MI are classified?. ### Response: 5.


Instruction: What are the performance and quality measures described in the current document relevant to?

Output: patients with spontaneous MI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the performance and quality measures described in the current document relevant to?. ### Response: patients with spontaneous MI.


Instruction: What type of MI is an event related to atherosclerotic plaque disruption?

Output: MI type 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of MI is an event related to atherosclerotic plaque disruption?. ### Response: MI type 1.


Instruction: What is MI type 2?

Output: myocardial injury

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is MI type 2?. ### Response: myocardial injury.


Instruction: What causes an imbalance between myocardial oxygen supply and/or demand?

Output: MI type 2 is myocardial injury caused by conditions other than coronary artery disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes an imbalance between myocardial oxygen supply and/or demand?. ### Response: MI type 2 is myocardial injury caused by conditions other than coronary artery disease.


Instruction: What is the difference between myocardial oxygen supply and/or demand?

Output: imbalance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between myocardial oxygen supply and/or demand?. ### Response: imbalance.


Instruction: What type of MI does the measure set developed by our writing committee apply only to?

Output: MI type 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of MI does the measure set developed by our writing committee apply only to?. ### Response: MI type 1.


Instruction: The measure set does not uniformly apply to how many types of MI?

Output: 4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The measure set does not uniformly apply to how many types of MI?. ### Response: 4.


Instruction: Aspirin and P2Y12 receptor inhibitor therapies are contraindicated in patients with what type of MI?

Output: MI type 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Aspirin and P2Y12 receptor inhibitor therapies are contraindicated in patients with what type of MI?. ### Response: MI type 2.


Instruction: What type of assays are widely used for markers?

Output: cardiac troponin levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of assays are widely used for markers?. ### Response: cardiac troponin levels.


Instruction: What biomarkers are used for markers of myocardial necrosis?

Output: cardiac troponin [cTn]

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What biomarkers are used for markers of myocardial necrosis?. ### Response: cardiac troponin [cTn].


Instruction: What is the name of a biomarker that is highly sensitive and specific?

Output: myocardial necrosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of a biomarker that is highly sensitive and specific?. ### Response: myocardial necrosis.


Instruction: Why are very small amounts of myonecrosis unreported?

Output: Given the widespread use of very sensitive assays for markers of myocardial necrosis (eg, the highly sensitive and specific cardiac troponin [cTn] biomarkers) and advanced imaging modalities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why are very small amounts of myonecrosis unreported?. ### Response: Given the widespread use of very sensitive assays for markers of myocardial necrosis (eg, the highly sensitive and specific cardiac troponin [cTn] biomarkers) and advanced imaging modalities.


Instruction: What has been associated with a higher incidence of sternal wound infections?

Output: they

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been associated with a higher incidence of sternal wound infections?. ### Response: they.