Instruction: What is the role of ischemia and infarction in late right ventricular dysfunction?

Output: after atrial repair of transposi-tion of the great arteries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of ischemia and infarction in late right ventricular dysfunction?. ### Response: after atrial repair of transposi-tion of the great arteries.


Instruction: What is a long-term follow-up of the atrial switch procedure?

Output: thirty years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a long-term follow-up of the atrial switch procedure?. ### Response: thirty years.


Instruction: What is the role of ischemia and infarction in late right ventricular dysfunction after atrial repair of transposi-tion of the great arteries?

Output: Role

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of ischemia and infarction in late right ventricular dysfunction after atrial repair of transposi-tion of the great arteries?. ### Response: Role.


Instruction: What is Schwerzmann M, Salehian O, Harris L, et al. after a Mustard operation?

Output: Ventricular arrhythmias and sudden death in adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Schwerzmann M, Salehian O, Harris L, et al. after a Mustard operation?. ### Response: Ventricular arrhythmias and sudden death in adults.


Instruction: What type of operation was performed for transposition of the great arteries in adults?

Output: atrial baffle procedure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of operation was performed for transposition of the great arteries in adults?. ### Response: atrial baffle procedure.


Instruction: What is the name of the single-centre experience of implantation of a cardioverter-defibrillator?

Output: Outcomes following the implantation of cardioverter-defibrillator for primary prevention in transposition of the great arteries after intra-atrial baffle repair

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the single-centre experience of implantation of a cardioverter-defibrillator?. ### Response: Outcomes following the implantation of cardioverter-defibrillator for primary prevention in transposition of the great arteries after intra-atrial baffle repair.


Instruction: What is a single-centre experience of intra-atrial baffle repair?

Output: Outcomes following the implantation of cardioverter-defibrillator for primary prevention in transposition of the great arteries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a single-centre experience of intra-atrial baffle repair?. ### Response: Outcomes following the implantation of cardioverter-defibrillator for primary prevention in transposition of the great arteries.


Instruction: What is the name of the multicenter analysis of internal cardioverter defibril-lator indications and therapies?

Output: Pacing Clin Electrophysiol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multicenter analysis of internal cardioverter defibril-lator indications and therapies?. ### Response: Pacing Clin Electrophysiol.


Instruction: How many patients were treated for d-transposition of the great arteries?

Output: 417

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated for d-transposition of the great arteries?. ### Response: 417.


Instruction: What is the cause of death in adults with congenital heart disease?

Output: Mode

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cause of death in adults with congenital heart disease?. ### Response: Mode.


Instruction: What was the Am J Cardiol. 2000:86:1111–6?

Output: Mode of death in adults with congenital heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the Am J Cardiol. 2000:86:1111–6?. ### Response: Mode of death in adults with congenital heart disease.


Instruction: How did Verheugt CL, Uiterwaal CS, van der Velde ET, et al. rate of death?

Output: 8-48

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Verheugt CL, Uiterwaal CS, van der Velde ET, et al. rate of death?. ### Response: 8-48.


Instruction: When did Eur Heart J. 2010:31:1220–9.

Output: S10.8-56

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Eur Heart J. 2010:31:1220–9.. ### Response: S10.8-56.


Instruction: What is a risk of sudden cardiac death after operation for common congenital heart defects?

Output: Ventricular arrhythmias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk of sudden cardiac death after operation for common congenital heart defects?. ### Response: Ventricular arrhythmias.


Instruction: What is an inbred consanguineous?

Output: genetic and phenotypic diversity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an inbred consanguineous?. ### Response: genetic and phenotypic diversity.


Instruction: What mutations are found in an inbred consanguineous population?

Output: NKX2-5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What mutations are found in an inbred consanguineous population?. ### Response: NKX2-5.


Instruction: What is the name of the gene that causes NKX2-5 mutations?

Output: consanguineous

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the gene that causes NKX2-5 mutations?. ### Response: consanguineous.


Instruction: When was Sci Rep. 5:8848 published?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Sci Rep. 5:8848 published?. ### Response: 2015.


Instruction: What are the acronyms and abbreviations for Chronic Heart Failure?

Output: Acute decompensated heart failure /Acute heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the acronyms and abbreviations for Chronic Heart Failure?. ### Response: Acute decompensated heart failure /Acute heart failure.


Instruction: What is the name of the acronym that is used to describe chronic heart failure?

Output: CHF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the acronym that is used to describe chronic heart failure?. ### Response: CHF.


Instruction: How long is the 6MWT?

Output: 6 Minute Walk Test

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the 6MWT?. ### Response: 6 Minute Walk Test.


Instruction: ACA ACC/AHA American College of Cardiology/American Heart Assocation AE Adverse events ACE Angiotensin converting enzyme inhibitors ACE-I What is the name of the disease that causes Acute Coronary Syndrome ADHF/AHF Acute decompensated heart failure/Acute heart failure ADMIRE -HF AdreView Myocardial Disease?

Output: ACS Acute Coronary Syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ACA ACC/AHA American College of Cardiology/American Heart Assocation AE Adverse events ACE Angiotensin converting enzyme inhibitors ACE-I What is the name of the disease that causes Acute Coronary Syndrome ADHF/AHF Acute decompensated heart failure/Acute heart failure ADMIRE -HF AdreView Myocardial Disease?. ### Response: ACS Acute Coronary Syndrome.


Instruction: ADMIRE -HF AdreView Myocardial Imaging for Risk Evaluation in Heart Failure AKI Acute kidney injury AMCKD Anaemia management in people with chronic kidney disease AUC Area under the curve ARA Action research arm

Output: Acute decompensated heart failure /Acute heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ADMIRE -HF AdreView Myocardial Imaging for Risk Evaluation in Heart Failure AKI Acute kidney injury AMCKD Anaemia management in people with chronic kidney disease AUC Area under the curve ARA Action research arm. ### Response: Acute decompensated heart failure /Acute heart failure.


Instruction: ARB Angiotensin II receptor blockers AROC Australasian Rehabilitation Outcomes Centre BBL BEST Beta -blocker Evaluation of Survival Trial BHF British Heart Foundation BMI

Output: ARA Action research arm  ARB Angiotensin II receptor blockers  ARD  Assessment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ARB Angiotensin II receptor blockers AROC Australasian Rehabilitation Outcomes Centre BBL BEST Beta -blocker Evaluation of Survival Trial BHF British Heart Foundation BMI. ### Response: ARA Action research arm  ARB Angiotensin II receptor blockers  ARD  Assessment.


Instruction: BHF British Heart Foundation BMI Body Mass Index BMT Best medical therapy BNF British National Formulary BNP B-type natriuretic peptide Blood pressure CAD Coronary artery disease CAS Complex Adaptive System

Output: Foundation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: BHF British Heart Foundation BMI Body Mass Index BMT Best medical therapy BNF British National Formulary BNP B-type natriuretic peptide Blood pressure CAD Coronary artery disease CAS Complex Adaptive System. ### Response: Foundation.


Instruction: CAS Complex Adaptive System CABG Coronary artery bypass grafting CC Comparative cost CCA Cost-consequence analysis CCS CDR Clinical Decision Rule CE Cost effective CEA Cost effectiveness analysis CERQual Confidence in the Evidence from Reviews of Qualitative Research’

Output: CC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: CAS Complex Adaptive System CABG Coronary artery bypass grafting CC Comparative cost CCA Cost-consequence analysis CCS CDR Clinical Decision Rule CE Cost effective CEA Cost effectiveness analysis CERQual Confidence in the Evidence from Reviews of Qualitative Research’. ### Response: CC.


Instruction: What group has CHF Chronic heart failure CI Confidence intervals CINAHL Cumulative Index of Nursing and Allied Health Literature?

Output: CG Control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What group has CHF Chronic heart failure CI Confidence intervals CINAHL Cumulative Index of Nursing and Allied Health Literature?. ### Response: CG Control.


Instruction: What is the name of the study that evaluated the long-term effects of an expanded cardiac rehabilita-tion programme after myocardial infarction or coronary artery bypass surgery?

Output: randomized controlled study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated the long-term effects of an expanded cardiac rehabilita-tion programme after myocardial infarction or coronary artery bypass surgery?. ### Response: randomized controlled study.


Instruction: How long was the follow-up of a randomized controlled study?

Output: five-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the follow-up of a randomized controlled study?. ### Response: five-year.


Instruction: What year did Clin Rehabil issue 25:79–87?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Clin Rehabil issue 25:79–87?. ### Response: 2011.


Instruction: What is the name of the study?

Output: randomized controlled study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study?. ### Response: randomized controlled study.


Instruction: When was the study published?

Output: April 26, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the study published?. ### Response: April 26, 2023.


Instruction: What is the effect of verapamil and angiotensin-converting enzyme inhibitors in patients with coronary artery disease and reduced left ventricular ejection fraction?

Output: 201

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of verapamil and angiotensin-converting enzyme inhibitors in patients with coronary artery disease and reduced left ventricular ejection fraction?. ### Response: 201.


Instruction: What are the mechanisms and management of acute myocardial infarction?

Output: Ventricular enlargement and remodeling fol-lowing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the mechanisms and management of acute myocardial infarction?. ### Response: Ventricular enlargement and remodeling fol-lowing.


Instruction: How many patients had suspected acute myocardial infarction?

Output: 13,634

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had suspected acute myocardial infarction?. ### Response: 13,634.


Instruction: What was the interim report from the Chinese Cardiac Study called?

Output: CCS-1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the interim report from the Chinese Cardiac Study called?. ### Response: CCS-1.


Instruction: When did the Lancet issue 345:686–687?

Output: 1995

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Lancet issue 345:686–687?. ### Response: 1995.


Instruction: How many patients were included in the ACE Inhibitor Myocardial Infarction Collaborative Group?

Output: 100,000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were included in the ACE Inhibitor Myocardial Infarction Collaborative Group?. ### Response: 100,000.


Instruction: What is ramipril used for in patients with clinical evidence of heart failure?

Output: mortality and morbidity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ramipril used for in patients with clinical evidence of heart failure?. ### Response: mortality and morbidity.


Instruction: What is the name of the study that investigated myocardial infarction with clinical evidence of heart failure?

Output: Acute Infarction Ramipril Efficacy (AIRE) Study Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated myocardial infarction with clinical evidence of heart failure?. ### Response: Acute Infarction Ramipril Efficacy (AIRE) Study Investigators.


Instruction: What is trandolapril an an-giotensin-converting-enzyme inhibitor?

Output: A clinical trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is trandolapril an an-giotensin-converting-enzyme inhibitor?. ### Response: A clinical trial.


Instruction: What is the name of the clinical trial of trandolapril in patients with left ventricular dysfunction after myocardial infarction?

Output: Trandolapril Cardiac Evaluation (TRACE) Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the clinical trial of trandolapril in patients with left ventricular dysfunction after myocardial infarction?. ### Response: Trandolapril Cardiac Evaluation (TRACE) Study Group.


Instruction: When did the TRACE Study Group begin?

Output: 1995

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the TRACE Study Group begin?. ### Response: 1995.


Instruction: What did Redelmeier DA find out about hyperkalemia after publica-tion of the Randomized Aldactone Evaluation Study?

Output: Rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Redelmeier DA find out about hyperkalemia after publica-tion of the Randomized Aldactone Evaluation Study?. ### Response: Rates.


Instruction: What was the N Engl J Med. 2004:351:543-551?

Output: Rates of hyperkalemia after publica-tion of the Randomized Aldactone Evaluation Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the N Engl J Med. 2004:351:543-551?. ### Response: Rates of hyperkalemia after publica-tion of the Randomized Aldactone Evaluation Study.


Instruction: What does STAT stand for?

Output: Studying the Treatment of Acute Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does STAT stand for?. ### Response: Studying the Treatment of Acute Hypertension.


Instruction: What is the name of the registry that studies the treatment of hypertension?

Output: Studying the Treatment of Acute Hypertension (STAT) Registry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the registry that studies the treatment of hypertension?. ### Response: Studying the Treatment of Acute Hypertension (STAT) Registry.


Instruction: What is the focus of the 2009 Focused Update?

Output: heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the focus of the 2009 Focused Update?. ### Response: heart failure.


Instruction: What are the 2009 guidelines for the diagnosis and management of heart failure?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the 2009 guidelines for the diagnosis and management of heart failure?. ### Response: 2005.


Instruction: What is the acronym for the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines?

Output: ACC/AHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines?. ### Response: ACC/AHA.


Instruction: In what year were the guidelines for the diagnosis and management of heart failure in adults developed?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year were the guidelines for the diagnosis and management of heart failure in adults developed?. ### Response: 2005.


Instruction: What was the name of the group that developed the guidelines?

Output: American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the group that developed the guidelines?. ### Response: American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.


Instruction: What year did Circulation. 2009:119:e391–e479.

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Circulation. 2009:119:e391–e479.. ### Response: 2009.


Instruction: Who is on the ADHERE Scientific Advisory Committee and Investigators?

Output: Adams KF Jr, Fonarow GC, Emerman CL, LeJemtel TH, Costanzo MR, Abraham WT, Berkowitz RL, Galvao M, Horton DP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is on the ADHERE Scientific Advisory Committee and Investigators?. ### Response: Adams KF Jr, Fonarow GC, Emerman CL, LeJemtel TH, Costanzo MR, Abraham WT, Berkowitz RL, Galvao M, Horton DP.


Instruction: What is a risk factor for sudden cardiac death in adults late in life?

Output: Left ventricular longitudinal function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for sudden cardiac death in adults late in life?. ### Response: Left ventricular longitudinal function.


Instruction: What is left ventricular dysfunction?

Output: a risk factor for sudden cardiac death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is left ventricular dysfunction?. ### Response: a risk factor for sudden cardiac death.


Instruction: When did N Engl J Med. 1993;329:593-9?

Output: 1993

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did N Engl J Med. 1993;329:593-9?. ### Response: 1993.


Instruction: What is a risk factor for sudden cardiac death in adults late after repair of tetralogy of Fallot?

Output: Left ventricular dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for sudden cardiac death in adults late after repair of tetralogy of Fallot?. ### Response: Left ventricular dysfunction.


Instruction: When did J Am Coll Cardiol. 2002;40:1675-80?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J Am Coll Cardiol. 2002;40:1675-80?. ### Response: 2002.


Instruction: What was a randomized trial of pulmo-nary valve replacement with and without right ventricular remodel-ing surgery?

Output: Circulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a randomized trial of pulmo-nary valve replacement with and without right ventricular remodel-ing surgery?. ### Response: Circulation.


Instruction: What is ventricular remodel-ing surgery called?

Output: beta-blockade

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ventricular remodel-ing surgery called?. ### Response: beta-blockade.


Instruction: What is the name of the multicentre study that examined risk factors for ar -rhythmia and sudden cardiac death late after repair of tetralogy of Fallot?

Output: Lancet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multicentre study that examined risk factors for ar -rhythmia and sudden cardiac death late after repair of tetralogy of Fallot?. ### Response: Lancet.


Instruction: In what year was the Lancet published in 356:975–81?

Output: 2000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was the Lancet published in 356:975–81?. ### Response: 2000.


Instruction: What is the difference between intervention and nonintervention in pulmonary valve replacement?

Output: Optimal timing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between intervention and nonintervention in pulmonary valve replacement?. ### Response: Optimal timing.


Instruction: What are the differences in surgical referral patterns in adults with tetralogy of Fallot with pulmonary regurgitation?

Output: Variability

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the differences in surgical referral patterns in adults with tetralogy of Fallot with pulmonary regurgitation?. ### Response: Variability.


Instruction: What is the best timing for pulmo-nary valve replacement in adults after tetralogy of Fallot repair?

Output: Twenty-to-thirty-seven-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the best timing for pulmo-nary valve replacement in adults after tetralogy of Fallot repair?. ### Response: Twenty-to-thirty-seven-year.


Instruction: What predicts sustained tachyarrhythmia in repaired tetralogy of Fallot?

Output: Right atrial area and right ventricular outflow tract akinetic length

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What predicts sustained tachyarrhythmia in repaired tetralogy of Fallot?. ### Response: Right atrial area and right ventricular outflow tract akinetic length.


Instruction: When did Bonello B, Kempny A, Uebing A, et al. perform a twenty-to-thirty-seven-year follow-up after repair?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Bonello B, Kempny A, Uebing A, et al. perform a twenty-to-thirty-seven-year follow-up after repair?. ### Response: 1999.


Instruction: How long after a fallot repair did Nrgaard MA, Lauridsen P, Helvind M follow up?

Output: Twenty-to-thirty-seven-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after a fallot repair did Nrgaard MA, Lauridsen P, Helvind M follow up?. ### Response: Twenty-to-thirty-seven-year.


Instruction: How many years follow-up after repair for tetralogy of Fallot?

Output: Twenty-to-thirty-seven

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many years follow-up after repair for tetralogy of Fallot?. ### Response: Twenty-to-thirty-seven.


Instruction: What year did Eur J Cardiothorac Surg.16:125-30?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Eur J Cardiothorac Surg.16:125-30?. ### Response: 1999.


Instruction: Silka MJ, Hardy BG, Menashe VD, et al. A population-based prospective evaluation of risk of sudden cardiac death after operation for com-mon congenital heart defects.

Output: Silka MJ, Hardy BG, Menashe VD, et al. A population-based prospec-tive evaluation of risk of sudden cardiac death after operation for com-mon congenital heart defects. J Am Coll Cardiol. 1998;32:245–51

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Silka MJ, Hardy BG, Menashe VD, et al. A population-based prospective evaluation of risk of sudden cardiac death after operation for com-mon congenital heart defects.. ### Response: Silka MJ, Hardy BG, Menashe VD, et al. A population-based prospec-tive evaluation of risk of sudden cardiac death after operation for com-mon congenital heart defects. J Am Coll Cardiol. 1998;32:245–51.


Instruction: What is the name of the study that evaluated beta-blockade in patients with heart defects?

Output: Norozi K, Bahlmann J, Raab B, et al. A prospective, randomized, double-blind, placebo controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated beta-blockade in patients with heart defects?. ### Response: Norozi K, Bahlmann J, Raab B, et al. A prospective, randomized, double-blind, placebo controlled trial.


Instruction: When did J Am Coll Cardiol. 1998 issue 32:245–51?

Output: 1998

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J Am Coll Cardiol. 1998 issue 32:245–51?. ### Response: 1998.


Instruction: What is another name for heart defect?

Output: Left ventricular dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for heart defect?. ### Response: Left ventricular dysfunction.


Instruction: How many patients underwent surgical correction of Fallot?

Output: Twenty-to-thirty-seven

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients underwent surgical correction of Fallot?. ### Response: Twenty-to-thirty-seven.


Instruction: What predicts life-threatening ventricular arrhythmia and death in adults with repaired tetralogy of Fallot?

Output: Left ventricular longitudinal function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What predicts life-threatening ventricular arrhythmia and death in adults with repaired tetralogy of Fallot?. ### Response: Left ventricular longitudinal function.


Instruction: When did Circulation. 2012:125:2440–6. S4.3.5-33. What predict ventricular arhythmiias and death?

Output: Left ventricular longitudinal function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circulation. 2012:125:2440–6. S4.3.5-33. What predict ventricular arhythmiias and death?. ### Response: Left ventricular longitudinal function.


Instruction: How do lesion-specific dif-ferences for implantable cardioverter defibrillator therapies affect adults with congenital heart?

Output: Variability in surgical referral patterns

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do lesion-specific dif-ferences for implantable cardioverter defibrillator therapies affect adults with congenital heart?. ### Response: Variability in surgical referral patterns.


Instruction: What type of defibrillator therapies can be used in adults with congenital heart disease?

Output: implantable cardioverter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of defibrillator therapies can be used in adults with congenital heart disease?. ### Response: implantable cardioverter.


Instruction: What is the pacing Clin Electrophysiol. 2014;37:1492-8?

Output: Lesion-specific dif-ferences for implantable cardioverter defibrillator therapies in adults with congenital heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the pacing Clin Electrophysiol. 2014;37:1492-8?. ### Response: Lesion-specific dif-ferences for implantable cardioverter defibrillator therapies in adults with congenital heart disease.


Instruction: Whose working groups recommend car-diovascular magnetic resonance?

Output: European Society of Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Whose working groups recommend car-diovascular magnetic resonance?. ### Response: European Society of Cardiology.


Instruction: What are the groups of the European Society of Cardiology?

Output: working groups

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the groups of the European Society of Cardiology?. ### Response: working groups.


Instruction: What is the name of the journal that published in 2010?

Output: Circulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that published in 2010?. ### Response: Circulation.


Instruction: What do we suggest in children with CKD?

Output: annualfollow-up measurement of fasting lipid levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do we suggest in children with CKD?. ### Response: annualfollow-up measurement of fasting lipid levels.


Instruction: What does CHAPTER 4: PHARMACOLOGICAL CHOLESTEROL-LOWERING TREATMENT IN CHILDREN?

Output: annualfollow-up measurement of fasting lipid levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CHAPTER 4: PHARMACOLOGICAL CHOLESTEROL-LOWERING TREATMENT IN CHILDREN?. ### Response: annualfollow-up measurement of fasting lipid levels.


Instruction: What do we suggest not be initiated in adults with CKD?

Output: statins or statin/ezetimibecombination

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do we suggest not be initiated in adults with CKD?. ### Response: statins or statin/ezetimibecombination.


Instruction: What are we suggesting that therapeutic lifestyle changes be advised?

Output: In adults with CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are we suggesting that therapeutic lifestyle changes be advised?. ### Response: In adults with CKD.


Instruction: What should be advised in children with CKD?

Output: therapeutic lifestyle changes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be advised in children with CKD?. ### Response: therapeutic lifestyle changes.


Instruction: What should therapeutic lifestyle changes beadvised?

Output: In children with CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should therapeutic lifestyle changes beadvised?. ### Response: In children with CKD.


Instruction: Who wrote a synopsis of clinical practice guideline?

Output: Wanner et al.:

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote a synopsis of clinical practice guideline?. ### Response: Wanner et al.:.


Instruction: Wanner et al.: Synopsis of clinical practice guideline on lipid management in CKD review?

Output: therapeutic lifestyle changes be advised

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Wanner et al.: Synopsis of clinical practice guideline on lipid management in CKD review?. ### Response: therapeutic lifestyle changes be advised.


Instruction: What did the AHA, European Society of Cardiology, British Society for Antimicrobial Chemotherapy and other leading groups do?

Output: limit the use of prophylactic antibiotic drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the AHA, European Society of Cardiology, British Society for Antimicrobial Chemotherapy and other leading groups do?. ### Response: limit the use of prophylactic antibiotic drugs.


Instruction: What was the impetus for extensive topical reviews of the development of antibiotic resistance?

Output: These issues

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the impetus for extensive topical reviews of the development of antibiotic resistance?. ### Response: These issues.


Instruction: What is the 2007 AHA guideline on "Prevention of Infective Endocarditis" similar to?

Output: European Society of Cardiology statement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2007 AHA guideline on "Prevention of Infective Endocarditis" similar to?. ### Response: European Society of Cardiology statement.


Instruction: What did the British guidelines carry the most revisions of?

Output: recommendations to eliminate prophylactic antibiotic drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the British guidelines carry the most revisions of?. ### Response: recommendations to eliminate prophylactic antibiotic drugs.


Instruction: What was NICE's recommendation to eliminate prophylactic antibiotic drugs for all patients under any circumstances?

Output: British guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was NICE's recommendation to eliminate prophylactic antibiotic drugs for all patients under any circumstances?. ### Response: British guidelines.


Instruction: What do the AHA and the European Society of Cardiology state-ments limit the use of?

Output: prophylactic antibiotic drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do the AHA and the European Society of Cardiology state-ments limit the use of?. ### Response: prophylactic antibiotic drugs.


Instruction: Patients in whom the risk for IE is highest are considered what?

Output: patients with a history of previous IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients in whom the risk for IE is highest are considered what?. ### Response: patients with a history of previous IE.


Instruction: What is the risk of IE in patients with a history of previous IE?

Output: highest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of IE in patients with a history of previous IE?. ### Response: highest.


Instruction: What should antibiotic drugs be considered for?

Output: those patients with the greatest risk for morbidity or mortality from IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should antibiotic drugs be considered for?. ### Response: those patients with the greatest risk for morbidity or mortality from IE.


Instruction: Who has the greatest risk of morbidity or mortality from IE, or who has the highest risk?

Output: heart transplant patients with a valvulopathy in the implanted heart

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who has the greatest risk of morbidity or mortality from IE, or who has the highest risk?. ### Response: heart transplant patients with a valvulopathy in the implanted heart.


Instruction: What is IE?

Output: infective endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is IE?. ### Response: infective endocarditis.


Instruction: How many studies have documented the lack of any demonstrable increase in IE as a cause of hospitalization for children?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies have documented the lack of any demonstrable increase in IE as a cause of hospitalization for children?. ### Response: 1.


Instruction: What country has carefully documented the absence of any impact on the rate of IE case development?

Output: United Kingdom

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What country has carefully documented the absence of any impact on the rate of IE case development?. ### Response: United Kingdom.


Instruction: Where have the NICE guidelines been in place and antibiotic dispensing for IE prophylaxis is moni-tored carefully?

Output: United Kingdom

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where have the NICE guidelines been in place and antibiotic dispensing for IE prophylaxis is moni-tored carefully?. ### Response: United Kingdom.


Instruction: Who can benefit from education about the importance of good oral health and the techniques useful for its maintenance?

Output: Children who are at risk for IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who can benefit from education about the importance of good oral health and the techniques useful for its maintenance?. ### Response: Children who are at risk for IE.


Instruction: Children with cyanosis may have specific periodontal concerns, which makes optimum oral hygiene particularly important for them?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Children with cyanosis may have specific periodontal concerns, which makes optimum oral hygiene particularly important for them?. ### Response: 3.


Instruction: What is particularly important for children and young adults?

Output: optimum oral hygiene

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is particularly important for children and young adults?. ### Response: optimum oral hygiene.


Instruction: What does the AHA recommend for those in the highest-risk groups?

Output: prophylactic antibiotic drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the AHA recommend for those in the highest-risk groups?. ### Response: prophylactic antibiotic drugs.


Instruction: What might increase as patients become subject to cardiovascular therapies for their CHD?

Output: their risk for IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What might increase as patients become subject to cardiovascular therapies for their CHD?. ### Response: their risk for IE.


Instruction: Valve replacement and septal defect occlusion with prosthetic devices are relevant exam-ples in what regard?

Output: IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Valve replacement and septal defect occlusion with prosthetic devices are relevant exam-ples in what regard?. ### Response: IE.


Instruction: What was the last review of IE prophylaxis?

Output: Table 10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the last review of IE prophylaxis?. ### Response: Table 10.


Instruction: What are the Clinical Situations Constituting High Risk for Complications of IEProsthetic cardiac valvesLeft-sided IEStaphylococcus aureus IEFungal IEPRevious IEProlonged clinical symptoms (>3 mo) Cyanotic congenital heart diseasePatients with systemic-to-pulmonary shuntsPoor clinical response to what?

Output: patients with a history of previous IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Clinical Situations Constituting High Risk for Complications of IEProsthetic cardiac valvesLeft-sided IEStaphylococcus aureus IEFungal IEPRevious IEProlonged clinical symptoms (>3 mo) Cyanotic congenital heart diseasePatients with systemic-to-pulmonary shuntsPoor clinical response to what?. ### Response: patients with a history of previous IE.


Instruction: What type of endocarditis does the response to antimicrobial therapy indicate?

Output: infective

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of endocarditis does the response to antimicrobial therapy indicate?. ### Response: infective.


Instruction: When was this article published?

Output: 1998

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this article published?. ### Response: 1998.


Instruction: Non-dihydropyri-dines interfere with the metabolism and excretion of what?

Output: theCNIs, cyclosporine and tacrolimus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Non-dihydropyri-dines interfere with the metabolism and excretion of what?. ### Response: theCNIs, cyclosporine and tacrolimus.


Instruction: What is the mammaliantarget of rapamycin?

Output: mTOR) inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the mammaliantarget of rapamycin?. ### Response: mTOR) inhibitors.


Instruction: What type of CKD requires immunosuppression?

Output: immune-mediated

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of CKD requires immunosuppression?. ### Response: immune-mediated.


Instruction: What are CNIs and mTOR inhibitors blood levels required to monitor?

Output: if drugs or dosagesare changed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are CNIs and mTOR inhibitors blood levels required to monitor?. ### Response: if drugs or dosagesare changed.


Instruction: Why do some clinicians use non-dihydropyridinecalcium-channel blockers?

Output: to increase CNI or mTOR inhibitorblood levels and thus reduce cost

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why do some clinicians use non-dihydropyridinecalcium-channel blockers?. ### Response: to increase CNI or mTOR inhibitorblood levels and thus reduce cost.


Instruction: What do centrally acting alpha-adrenergic agonists cause?

Output: vasodilatation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do centrally acting alpha-adrenergic agonists cause?. ### Response: vasodilatation.


Instruction: What are the mainagents in use?

Output: methyldopa, clonidine, and moxonidine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the mainagents in use?. ### Response: methyldopa, clonidine, and moxonidine.


Instruction: When was moxonidine not widely available?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was moxonidine not widely available?. ### Response: 2004.


Instruction: What are the KDOQI Clinical Practice Guidelines on?

Output: Hypertension and Antihypertensives Agents in Chronic KidneyDisease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the KDOQI Clinical Practice Guidelines on?. ### Response: Hypertension and Antihypertensives Agents in Chronic KidneyDisease.


Instruction: Who reviewed the use of this drug in essential hypertension in 2006?

Output: Fenton at al.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who reviewed the use of this drug in essential hypertension in 2006?. ### Response: Fenton at al..


Instruction: What are antihypertensive orimmunosuppressants valuable as adjunct therapy for?

Output: resistant hypertension in CKD patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are antihypertensive orimmunosuppressants valuable as adjunct therapy for?. ### Response: resistant hypertension in CKD patients.


Instruction: Doses of methyl-dopa or clonidine are not generally reduced in patients with impaired kidney function?

Output: Moxonidine is extensively excretedby the kidney and accordingly it has been recommended thatthe dosage (usually 200 to 400 mg daily) should be reduced inthe presence of a low GFR.134

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Doses of methyl-dopa or clonidine are not generally reduced in patients with impaired kidney function?. ### Response: Moxonidine is extensively excretedby the kidney and accordingly it has been recommended thatthe dosage (usually 200 to 400 mg daily) should be reduced inthe presence of a low GFR.134.


Instruction: What is extensively excreted by the kidney?

Output: Moxonidine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is extensively excreted by the kidney?. ### Response: Moxonidine.


Instruction: What should be reduced in the presence of a low GFR?

Output: Moxonidine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be reduced in the presence of a low GFR?. ### Response: Moxonidine.


Instruction: How many hypertensive CKD patients were treated with an RCT ofmoxonidine?

Output: 177

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many hypertensive CKD patients were treated with an RCT ofmoxonidine?. ### Response: 177.


Instruction: What is the daily dose of calcium-channel blockernitrendipine?

Output: 20 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the daily dose of calcium-channel blockernitrendipine?. ### Response: 20 mg.


Instruction: How many hypertensive CKD patients were treated with ACE-I or ARB plusloop diuretic?

Output: 177

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many hypertensive CKD patients were treated with ACE-I or ARB plusloop diuretic?. ### Response: 177.


Instruction: What was the percentage of patients treated with moxonidine that had adverse events?

Output: 56.2%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the percentage of patients treated with moxonidine that had adverse events?. ### Response: 56.2%.


Instruction: What percentage of adverse events were due to moxonidine?

Output: 28%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of adverse events were due to moxonidine?. ### Response: 28%,.


Instruction: What is the percentage of side effects of nitrendi-pine?

Output: 32%),

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the percentage of side effects of nitrendi-pine?. ### Response: 32%),.


Instruction: What is the acronym for non-dihydropyridine benzothiazepine?

Output: Verapamil P N Y YB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for non-dihydropyridine benzothiazepine?. ### Response: Verapamil P N Y YB.


Instruction: What is calcineurin inhibitor?

Output: CNI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is calcineurin inhibitor?. ### Response: CNI.


Instruction: What is the phenylalkylamine?

Output: P

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the phenylalkylamine?. ### Response: P.


Instruction: What is Y?

Output: Yes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Y?. ### Response: Yes.


Instruction: What does AMS care have a very low certainty of having an effect on?

Output: mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does AMS care have a very low certainty of having an effect on?. ### Response: mortality.


Instruction: How many studies focused on VKA treatment?

Output: all but 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies focused on VKA treatment?. ### Response: all but 2.


Instruction: What is most likely to be beneficial when patients using VKA?

Output: educational interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is most likely to be beneficial when patients using VKA?. ### Response: educational interventions.


Instruction: What is most likely to be beneficial when implemented in a population with inadequate TTR managed by nonspecializedproviders?

Output: AMS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is most likely to be beneficial when implemented in a population with inadequate TTR managed by nonspecializedproviders?. ### Response: AMS.


Instruction: What should decision-makers consider the upfront costs of setting up the AMS as well as costs to maintain the service?

Output: AMS is most likely to be beneficial when implementedin a population with inadequate TTR managed by nonspecializedproviders

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should decision-makers consider the upfront costs of setting up the AMS as well as costs to maintain the service?. ### Response: AMS is most likely to be beneficial when implementedin a population with inadequate TTR managed by nonspecializedproviders.


Instruction: What can AMS provide for health care providers in the region?

Output: specialized consulting andeducation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can AMS provide for health care providers in the region?. ### Response: specialized consulting andeducation.


Instruction: What should AMS providers keep track of?

Output: theservice ’s TTR as well as anticoagulation-related clinical outcomesfor their patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should AMS providers keep track of?. ### Response: theservice ’s TTR as well as anticoagulation-related clinical outcomesfor their patients.


Instruction: What should health care providers keep track of when referring patients to an AMS?

Output: whether they attended the AMS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should health care providers keep track of when referring patients to an AMS?. ### Response: whether they attended the AMS.


Instruction: What needs to be strengthened to be considered superior to reported observational evidence?

Output: RCTevidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What needs to be strengthened to be considered superior to reported observational evidence?. ### Response: RCTevidence.


Instruction: Cluster RCTs are needed that enroll patients before what?

Output: unblinding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cluster RCTs are needed that enroll patients before what?. ### Response: unblinding.


Instruction: What is needed that enroll patients before unblinding ofallocation?

Output: Cluster RCTs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed that enroll patients before unblinding ofallocation?. ### Response: Cluster RCTs.


Instruction: What is required that are sufficiently powered to detect a difference in clinicaloutcomes using blinded outcome assessment?

Output: Cluster RCTs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is required that are sufficiently powered to detect a difference in clinicaloutcomes using blinded outcome assessment?. ### Response: Cluster RCTs.


Instruction: What does the ASH guideline panel recommend for patients receiving oral anticoagulation therapy for VTE treatment?

Output: using supple-mentary patient education

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the ASH guideline panel recommend for patients receiving oral anticoagulation therapy for VTE treatment?. ### Response: using supple-mentary patient education.


Instruction: What should supplementary patient education be offered vs?

Output: no supplementary patient education

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should supplementary patient education be offered vs?. ### Response: no supplementary patient education.


Instruction: Who recommends using supplementary patient education in addition to DOAC therapy?

Output: ASH guideline panel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who recommends using supplementary patient education in addition to DOAC therapy?. ### Response: ASH guideline panel.


Instruction: What does the guideline panel suggest using in addition to basic education for patients receiving oral anticoagulation for VTE treatment?

Output: supple-mentary patient education

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the guideline panel suggest using in addition to basic education for patients receiving oral anticoagulation for VTE treatment?. ### Response: supple-mentary patient education.


Instruction: What is the conditional recommendation based on?

Output: very low certainty in theevidence about effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the conditional recommendation based on?. ### Response: very low certainty in theevidence about effects.


Instruction: What does prescribing anticoagulantprescribing improve?

Output: anticoagulation therapy outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does prescribing anticoagulantprescribing improve?. ### Response: anticoagulation therapy outcomes.


Instruction: What did a systematic review conclude was not sufficient to support supplemental patienteducation?

Output: improveoutcomes for patients with VTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a systematic review conclude was not sufficient to support supplemental patienteducation?. ### Response: improveoutcomes for patients with VTE.


Instruction: What was not sufficient to support supplemental patient education to improve outcomes for patients with VTE?

Output: evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not sufficient to support supplemental patient education to improve outcomes for patients with VTE?. ### Response: evidence.


Instruction: The quality of evidence included in this review was deemed to have what?

Output: very low certainty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The quality of evidence included in this review was deemed to have what?. ### Response: very low certainty.


Instruction: Weincluded how many RCTs evaluating patients receiving anticoagulationtherapy?

Output: 8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Weincluded how many RCTs evaluating patients receiving anticoagulationtherapy?. ### Response: 8.


Instruction: How many studies reported the effect of supplemental education interventions on mortality?

Output: One

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies reported the effect of supplemental education interventions on mortality?. ### Response: One.


Instruction: What is an ICD recommended in patients with SCA due to VT or VF in the absence of reversible causes?

Output: if meaningful survival of greater than 1 year is expected

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an ICD recommended in patients with SCA due to VT or VF in the absence of reversible causes?. ### Response: if meaningful survival of greater than 1 year is expected.


Instruction: What is a meaningful survival of greater than 1 year?

Output: implantation of an ICD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a meaningful survival of greater than 1 year?. ### Response: implantation of an ICD.


Instruction: What is recommended if meaningful survival of greater than 1 year is expected?

Output: implantation of an ICD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended if meaningful survival of greater than 1 year is expected?. ### Response: implantation of an ICD.


Instruction: In adults with repaired tetralogy of Fallot physiology with high-risk characteristics and frequent VA, what can be useful to evaluate the risk of sustained VT/VF?

Output: an electrophysiological study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In adults with repaired tetralogy of Fallot physiology with high-risk characteristics and frequent VA, what can be useful to evaluate the risk of sustained VT/VF?. ### Response: an electrophysiological study.


Instruction: What is implantation of an ICD reasonable in adults with repaired tetralogy of Fallot physiology and inducible VT/VF or spontaneous sustained VT?

Output: if meaningful survival greater than 1 year is expected

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is implantation of an ICD reasonable in adults with repaired tetralogy of Fallot physiology and inducible VT/VF or spontaneous sustained VT?. ### Response: if meaningful survival greater than 1 year is expected.


Instruction: What is reasonable if meaningful survival greater than 1 year is expected?

Output: implantation of an ICD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable if meaningful survival greater than 1 year is expected?. ### Response: implantation of an ICD.


Instruction: What can be effective in congenital heart disease with recurrent sustained monomorphic VT?

Output: catheter ablation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be effective in congenital heart disease with recurrent sustained monomorphic VT?. ### Response: catheter ablation.


Instruction: What is a beta blocker beneficial to reduce the risk of?

Output: SCA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a beta blocker beneficial to reduce the risk of?. ### Response: SCA.


Instruction: What can be beneficial to reduce the risk of SCA?

Output: a beta blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be beneficial to reduce the risk of SCA?. ### Response: a beta blocker.


Instruction: What is reasonable in patients with repaired moderate or severe complexity adult congenital heart disease with unexplained syncope?

Output: either ICD implantation or an electrophysiological study with ICD implantation for inducible sustained VA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable in patients with repaired moderate or severe complexity adult congenital heart disease with unexplained syncope?. ### Response: either ICD implantation or an electrophysiological study with ICD implantation for inducible sustained VA.


Instruction: ICD implantation for inducible sustained VA is reasonable if meaningful survival of greater than what is expected?

Output: 1 year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ICD implantation for inducible sustained VA is reasonable if meaningful survival of greater than what is expected?. ### Response: 1 year.


Instruction: In patients with adult congenital heart disease and severe ventricular dysfunction (LVEF 35%) and symptoms of heart failure despite GDMT or additional risk factors, what may be reasonable?

Output: implantation of an ICD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with adult congenital heart disease and severe ventricular dysfunction (LVEF 35%) and symptoms of heart failure despite GDMT or additional risk factors, what may be reasonable?. ### Response: implantation of an ICD.


Instruction: What may be considered if meaningful survival of greater than 1 year is expected?

Output: implantation of an ICD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered if meaningful survival of greater than 1 year is expected?. ### Response: implantation of an ICD.


Instruction: In patients with adult congenital heart disease who have asymptomatic VA, what is potentially harmful?

Output: prophylactic antiarrhythmic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with adult congenital heart disease who have asymptomatic VA, what is potentially harmful?. ### Response: prophylactic antiarrhythmic therapy.


Instruction: What is the term for congenital heart disease with RVOT obstruction and ventricular septal defect?

Output: Tetralogy of Fallot

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for congenital heart disease with RVOT obstruction and ventricular septal defect?. ### Response: Tetralogy of Fallot.


Instruction: What type of medications are potentially harmful?

Output: prophylactic antiarrhythmic therapy with class Ic medications (ie, flecainide, propafenone) or amiodarone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of medications are potentially harmful?. ### Response: prophylactic antiarrhythmic therapy with class Ic medications (ie, flecainide, propafenone) or amiodarone.


Instruction: What type of heart disease is de-fined as congenital heart disease requiring intracardiac surgical repair?

Output: Moderate complexity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of heart disease is de-fined as congenital heart disease requiring intracardiac surgical repair?. ### Response: Moderate complexity.


Instruction: Tof, aortic stenosis, coarctation of aaorta, and Ebstein anomaly of the tricuspid valve are examples of what?

Output: Moderate complexity congenital heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Tof, aortic stenosis, coarctation of aaorta, and Ebstein anomaly of the tricuspid valve are examples of what?. ### Response: Moderate complexity congenital heart disease.


Instruction: What type of heart disease is defined as cyanotic congenital heart disease requiring intracar -diac repair in infancy?

Output: Severe complexity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of heart disease is defined as cyanotic congenital heart disease requiring intracar -diac repair in infancy?. ### Response: Severe complexity.


Instruction: What is tricuspid valve?

Output: Ebstein anomaly

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is tricuspid valve?. ### Response: Ebstein anomaly.


Instruction: What is the ideal blood pressure goal for patients with stage III or higher chronic kidney disease?

Output: 58. Khouri Y , Steigerwalt SP, Alsamara M, McCullough PA. What is the ideal blood pressure goal for patients with stage III or higher chronic kidney disease? Curr Cardiol Rep. 2011;13:492–501

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ideal blood pressure goal for patients with stage III or higher chronic kidney disease?. ### Response: 58. Khouri Y , Steigerwalt SP, Alsamara M, McCullough PA. What is the ideal blood pressure goal for patients with stage III or higher chronic kidney disease? Curr Cardiol Rep. 2011;13:492–501.


Instruction: What does Karohi C, Raggi P say about cardiovascular disease prevention?

Output: Approach to cardiovascular disease prevention in patients with chronic kidney disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Karohi C, Raggi P say about cardiovascular disease prevention?. ### Response: Approach to cardiovascular disease prevention in patients with chronic kidney disease.


Instruction: What is the name of the second edition of Hypertension: A Companion to Braunwald’s Heart Disease?

Output: 2012:12–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the second edition of Hypertension: A Companion to Braunwald’s Heart Disease?. ### Response: 2012:12–.


Instruction: What are the mediators linking adipose tissue, inflammation and immunity?

Output: Adipocytokines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the mediators linking adipose tissue, inflammation and immunity?. ### Response: Adipocytokines.


Instruction: What is the name of the journal that studies adipocytokines?

Output: Nat Rev Immunol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies adipocytokines?. ### Response: Nat Rev Immunol.


Instruction: What is a risk factor for atherosclerotic vascular disease?

Output: impact on large artery stiffness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for atherosclerotic vascular disease?. ### Response: impact on large artery stiffness.


Instruction: What is an example of a gene polymorphism in Egyptians with premature coronary artery disease in 2012?

Output: Renin-angiotensin system

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a gene polymorphism in Egyptians with premature coronary artery disease in 2012?. ### Response: Renin-angiotensin system.


Instruction: What is a risk factor for ST-segment-elevation myocardial infarction?

Output: coro-nary artery disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for ST-segment-elevation myocardial infarction?. ### Response: coro-nary artery disease.


Instruction: What are the risk factors for coro-nary artery disease in Egyptians?

Output: Renin-angiotensin system genes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the risk factors for coro-nary artery disease in Egyptians?. ### Response: Renin-angiotensin system genes.


Instruction: What are the pharmacogenetic associations of MMP9 and MMP12 variants with cardiovascular disease in patients with hypertension?

Output: 66

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the pharmacogenetic associations of MMP9 and MMP12 variants with cardiovascular disease in patients with hypertension?. ### Response: 66.


Instruction: What is the name of the person who was a part of the study?

Output: Franklin SS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the person who was a part of the study?. ### Response: Franklin SS.


Instruction: Who is the author of the paper?

Output: Franklin SS, Gustin W 4th, Wong ND, Larson MG, Weber MA, Kannel WB, Levy D

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of the paper?. ### Response: Franklin SS, Gustin W 4th, Wong ND, Larson MG, Weber MA, Kannel WB, Levy D.


Instruction: What was the author's name?

Output: Franklin SS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the author's name?. ### Response: Franklin SS.


Instruction: What is the name of the 3rd ed. of Etiology and Pathogenesis of Systemic Hypertension?

Output: Crawford MH, DiMarco JP, Paulus WJ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 3rd ed. of Etiology and Pathogenesis of Systemic Hypertension?. ### Response: Crawford MH, DiMarco JP, Paulus WJ.


Instruction: What is the name of the 3rd ed. on Etiology and Pathogenesis of Systemic Hypertension?

Output: Crawford MH, DiMarco JP, Paulus WJ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 3rd ed. on Etiology and Pathogenesis of Systemic Hypertension?. ### Response: Crawford MH, DiMarco JP, Paulus WJ.


Instruction: What are the names of the authors of the 4th Ed.?

Output: Franklin SS, Gustin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the authors of the 4th Ed.?. ### Response: Franklin SS, Gustin.


Instruction: In what year was Hypertension published?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was Hypertension published?. ### Response: 2007.


Instruction: What is the impact of age-related medial elastocalcinosis on large artery stiffness and isolated systolic hypertension?

Output: Evolution and modulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact of age-related medial elastocalcinosis on large artery stiffness and isolated systolic hypertension?. ### Response: Evolution and modulation.


Instruction: The Framingham Heart Study. 1997;96:308-315.

Output: 71. Franklin SS, Gustin W 4th, Wong ND, Larson MG, Weber MA, Kannel WB, Levy D. Hemodynamic patterns of age-related changes in blood pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The Framingham Heart Study. 1997;96:308-315.. ### Response: 71. Franklin SS, Gustin W 4th, Wong ND, Larson MG, Weber MA, Kannel WB, Levy D. Hemodynamic patterns of age-related changes in blood pressure.


Instruction: Blood pressure: the Framingham Heart Study. Circulation. 1997;96:308–315.

Output: 71

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Blood pressure: the Framingham Heart Study. Circulation. 1997;96:308–315.. ### Response: 71.


Instruction: Pimenta E, Oparil S. Management of hypertension in the elderly. Orthop Cardiol. 2012;9:286–296.

Output: 72

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Pimenta E, Oparil S. Management of hypertension in the elderly. Orthop Cardiol. 2012;9:286–296.. ### Response: 72.


Instruction: What year was the CD003813 released?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the CD003813 released?. ### Response: 2013.


Instruction: What is the difference between tooth brushing and single tooth extraction?

Output: Associations between bacteremia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between tooth brushing and single tooth extraction?. ### Response: Associations between bacteremia.


Instruction: Where can you find this article?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find this article?. ### Response: http://ahajournals.org.


Instruction: What is the 2014 AHA/ACC NSTE-ACS Guideline e405 448?

Output: Amsterdam et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2014 AHA/ACC NSTE-ACS Guideline e405 448?. ### Response: Amsterdam et al.


Instruction: What does Holmes DR Jr, Dehmer GJ, Kaul S, et al. call the FDA's "boxed warning"?

Output: ACCF/AHA clopidogrel clinical alert

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Holmes DR Jr, Dehmer GJ, Kaul S, et al. call the FDA's "boxed warning"?. ### Response: ACCF/AHA clopidogrel clinical alert.


Instruction: When did Circulation. 2010;122:537–57?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circulation. 2010;122:537–57?. ### Response: 2013.


Instruction: What is secondary prevention?

Output: Cardiac rehabilitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is secondary prevention?. ### Response: Cardiac rehabilitation.


Instruction: What is a scientific statement from the American Heart Association?

Output: Exercise standards for testing and training

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a scientific statement from the American Heart Association?. ### Response: Exercise standards for testing and training.


Instruction: What are the core components of cardiac reha-bilitation programs?

Output: secondary prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the core components of cardiac reha-bilitation programs?. ### Response: secondary prevention.


Instruction: What is the Council on Clinical Cardiology?

Output: Subcommittee on Exercise, Rehabilitation, and Prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Council on Clinical Cardiology?. ### Response: Subcommittee on Exercise, Rehabilitation, and Prevention.


Instruction: What are the Councils on Cardiovascular Nursing, Epidemology and Prevention, and Nutrition, Physical Activity, and Metabolism?

Output: Subcommittee on Physical Activity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Councils on Cardiovascular Nursing, Epidemology and Prevention, and Nutrition, Physical Activity, and Metabolism?. ### Response: Subcommittee on Physical Activity.


Instruction: Exercise-based rehabilitation for patients with coronary heart disease: systematic review and meta-analysis of randomized controlled trials?

Output: 452

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Exercise-based rehabilitation for patients with coronary heart disease: systematic review and meta-analysis of randomized controlled trials?. ### Response: 452.


Instruction: What is the name of the study that evaluated exercise based rehabilitation?

Output: randomized controlled trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated exercise based rehabilitation?. ### Response: randomized controlled trials.


Instruction: What is the name of the Task Force on Performance Measures?

Output: American College of Cardiology/American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Performance Measures?. ### Response: American College of Cardiology/American Heart Association.


Instruction: Along with the American Academy of Family Physicians and American College of Emergency Physicians, what other organization collaborated on this report?

Output: American College of Cardiology/American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Along with the American Academy of Family Physicians and American College of Emergency Physicians, what other organization collaborated on this report?. ### Response: American College of Cardiology/American Heart Association.


Instruction: What type of myocardial infarction is a ST-elevation and non-ST-Elevation?

Output: ST-elevation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of myocardial infarction is a ST-elevation and non-ST-Elevation?. ### Response: ST-elevation.


Instruction: Who is a member of the American College of Emergency Physicians?

Output: American Academy of Family Physicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a member of the American College of Emergency Physicians?. ### Response: American Academy of Family Physicians.


Instruction: When was the AACVPR/ACCF/AHA updated?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the AACVPR/ACCF/AHA updated?. ### Response: 2010.


Instruction: What is the name of the 2007 update?

Output: a scientific statement from the American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2007 update?. ### Response: a scientific statement from the American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee.


Instruction: What is the purpose of exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease?

Output: testing and training

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease?. ### Response: testing and training.


Instruction: What are the perfor -mance measures on cardiac rehabilitation for?

Output: referral to and delivery of cardiac rehabilitation/secondary prevention services

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the perfor -mance measures on cardiac rehabilitation for?. ### Response: referral to and delivery of cardiac rehabilitation/secondary prevention services.


Instruction: What is a subcommittee on exercise, rehabilitation, and prevention?

Output: Council on Clinical Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a subcommittee on exercise, rehabilitation, and prevention?. ### Response: Council on Clinical Cardiology.


Instruction: What is another subcomitee of the Council on Nutrition, Physical Activity and Metabolism?

Output: Cardiovascular Nursing, Epidemiology and Prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another subcomitee of the Council on Nutrition, Physical Activity and Metabolism?. ### Response: Cardiovascular Nursing, Epidemiology and Prevention.


Instruction: What is Thompson PD's specialty?

Output: Exercise prescription and proscription for patients with coronary artery disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Thompson PD's specialty?. ### Response: Exercise prescription and proscription for patients with coronary artery disease.


Instruction: What is exercise prescription and proscription for patients with coronary artery disease?

Output: Thompson PD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is exercise prescription and proscription for patients with coronary artery disease?. ### Response: Thompson PD.


Instruction: What should maximally tolerated LDL-C lowering therapy include?

Output: maximally tolerated statin therapy and ezetimibe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should maximally tolerated LDL-C lowering therapy include?. ### Response: maximally tolerated statin therapy and ezetimibe.


Instruction: In patients with clinical ASCVD who are judged to be very high risk and considered for PCSK9 inhibitor therapy, what should include maximally tolerable statin therapy and ezetimibe?

Output: maximally tolerated LDL-C lowering therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with clinical ASCVD who are judged to be very high risk and considered for PCSK9 inhibitor therapy, what should include maximally tolerable statin therapy and ezetimibe?. ### Response: maximally tolerated LDL-C lowering therapy.


Instruction: What type of ASCVD is considered to be very high risk?

Output: clinical

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of ASCVD is considered to be very high risk?. ### Response: clinical.


Instruction: What is the maximum tolerated LDL-C lowering therapy?

Output: LDL-C 70 mg/dL or higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the maximum tolerated LDL-C lowering therapy?. ### Response: LDL-C 70 mg/dL or higher.


Instruction: How is it reasonable to add a PCSK9 inhibitor following a clinician-patient discussion?

Output: net benefit, safety, and cost

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is it reasonable to add a PCSK9 inhibitor following a clinician-patient discussion?. ### Response: net benefit, safety, and cost.


Instruction: What is a reasonable reason to add a PCSK9 inhibitor?

Output: following a clinician–patient discussion about the net benefit, safety, and cost

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a reasonable reason to add a PCSK9 inhibitor?. ### Response: following a clinician–patient discussion about the net benefit, safety, and cost.


Instruction: What is the LDL-C level of patients with ASCVD that are on statin therapy?

Output: 70 mg/dL or higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the LDL-C level of patients with ASCVD that are on statin therapy?. ### Response: 70 mg/dL or higher.


Instruction: What is the LDL-C level?

Output: low-density lipoprotein cholesterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the LDL-C level?. ### Response: low-density lipoprotein cholesterol.


Instruction: What is ezetimibe therapy reasonable for?

Output: patients with clinical ASCVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ezetimibe therapy reasonable for?. ### Response: patients with clinical ASCVD.


Instruction: How many mg of Atorvastatin does it take to reduce LDL-C?

Output: 80 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mg of Atorvastatin does it take to reduce LDL-C?. ### Response: 80 mg.


Instruction: What is the name of the primary statin medications used in clinical practice?

Output: atorvastatin, rosuvastatin, simvastatin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the primary statin medications used in clinical practice?. ### Response: atorvastatin, rosuvastatin, simvastatin.


Instruction: What were the primary statin medications used in clinical practice estimated using?

Output: median reduction in LDL-C from the VOYAGER database

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the primary statin medications used in clinical practice estimated using?. ### Response: median reduction in LDL-C from the VOYAGER database.


Instruction: What was the median reduction in LDL-C from the VOYAGER database?

Output: S3.2.1-2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the median reduction in LDL-C from the VOYAGER database?. ### Response: S3.2.1-2.


Instruction: In adults with hyperlipidemia, primary hypercholesterolemia, and mixed conditions, what were the reductions for other statin drugs identified according to?

Output: FDA-approved product labeling

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In adults with hyperlipidemia, primary hypercholesterolemia, and mixed conditions, what were the reductions for other statin drugs identified according to?. ### Response: FDA-approved product labeling.


Instruction: What does Boldface type indicate?

Output: specific statins and doses that were evaluated in RCTs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Boldface type indicate?. ### Response: specific statins and doses that were evaluated in RCTs.


Instruction: What did the Cholesterol Treatment Trialists' 2010 meta-analysis show?

Output: a reduction in major cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Cholesterol Treatment Trialists' 2010 meta-analysis show?. ### Response: a reduction in major cardiovascular events.


Instruction: What are reductions estimates from?

Output: data across large populations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are reductions estimates from?. ### Response: data across large populations.


Instruction: Individual responses to statin therapy should vary in what?

Output: RCTs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Individual responses to statin therapy should vary in what?. ### Response: RCTs.


Instruction: What should occur with the dosage listed below each intensity?

Output: LDL-C lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should occur with the dosage listed below each intensity?. ### Response: LDL-C lowering.


Instruction: What was the name of the study that evaluated simvastatin 80 mg in RCTs?

Output: IDEAL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the study that evaluated simvastatin 80 mg in RCTs?. ### Response: IDEAL.


Instruction: Why is titration to 80 mg not recommended by the FDA?

Output: increased risk of myopathy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is titration to 80 mg not recommended by the FDA?. ### Response: increased risk of myopathy.


Instruction: What does BID mean?

Output: twice daily

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does BID mean?. ### Response: twice daily.


Instruction: What does LDL-C stand for?

Output: low-density lipoprotein cholesterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does LDL-C stand for?. ### Response: low-density lipoprotein cholesterol.


Instruction: Which FDA agency is responsible for myopathy?

Output: US Food and Drug Administration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which FDA agency is responsible for myopathy?. ### Response: US Food and Drug Administration.


Instruction: What did Casey and colleagues review in developing the updated HBP measure set?

Output: evidence-based guidelines and statements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Casey and colleagues review in developing the updated HBP measure set?. ### Response: evidence-based guidelines and statements.


Instruction: What did the writ-ing committee review that could potentially impact the construc-tion of the measures?

Output: evidence-based guidelines and statements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the writ-ing committee review that could potentially impact the construc-tion of the measures?. ### Response: evidence-based guidelines and statements.


Instruction: What could potentially impact the construc-tion of the measures?

Output: evidence-based guidelines and statements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could potentially impact the construc-tion of the measures?. ### Response: evidence-based guidelines and statements.


Instruction: What are the clinical practice guidelines and scientific statements that most directly contributed to the development of these measures shown in?

Output: Table 6.2.2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the clinical practice guidelines and scientific statements that most directly contributed to the development of these measures shown in?. ### Response: Table 6.2.2.


Instruction: What did the committee create for ACC/AHA stage 2 HBP that are aligned with these other groups?

Output: harmonizing measures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee create for ACC/AHA stage 2 HBP that are aligned with these other groups?. ### Response: harmonizing measures.