Instruction: What are Long-Term Outcomes?

Output: Patients With Previous Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are Long-Term Outcomes?. ### Response: Patients With Previous Stroke.


Instruction: Patients With Previous Stroke............................................................

Output: .e6986.10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients With Previous Stroke............................................................. ### Response: .e6986.10.


Instruction: What is the difference between PCI and CABG?

Output: Cost-Effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between PCI and CABG?. ### Response: Cost-Effectiveness.


Instruction: What are the future research directions for CABG and PCI?

Output: .e6998

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the future research directions for CABG and PCI?. ### Response: .e6998.


Instruction: How is teaching CABG to the next generation?

Output: Use of Surgical Simulators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is teaching CABG to the next generation?. ### Response: Use of Surgical Simulators.


Instruction: What do Reviewer Relationships With Industry and Other Entities (Relevant) relate to?

Output: Author

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do Reviewer Relationships With Industry and Other Entities (Relevant) relate to?. ### Response: Author.


Instruction: What is the name of the study group that studies Maximal Individual Therapy inAcute Myocardial Infarction?

Output: MITRA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study group that studies Maximal Individual Therapy inAcute Myocardial Infarction?. ### Response: MITRA.


Instruction: What is MITRA?

Output: Maximal Individual Therapy inAcute Myocardial Infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is MITRA?. ### Response: Maximal Individual Therapy inAcute Myocardial Infarction.


Instruction: What is aproposity analysis of acute ST-segment elevation myocar-dialinfarction in patients with contraindications to thrombolytic therapy?

Output: Mortality benefit ofimmediate revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is aproposity analysis of acute ST-segment elevation myocar-dialinfarction in patients with contraindications to thrombolytic therapy?. ### Response: Mortality benefit ofimmediate revascularization.


Instruction: What is the name of the study that compares conservative therapy with primary angioplasty?

Output: Maximal Individual Therapy inAcute Myocardial Infarction (MITRA) Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that compares conservative therapy with primary angioplasty?. ### Response: Maximal Individual Therapy inAcute Myocardial Infarction (MITRA) Study Group.


Instruction: What is apropensity analysis?

Output: Mortality benefit ofimmediate revascularization of acute ST-segment elevation myocar-dialinfarction in patients with contraindications to thrombolytic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is apropensity analysis?. ### Response: Mortality benefit ofimmediate revascularization of acute ST-segment elevation myocar-dialinfarction in patients with contraindications to thrombolytic therapy.


Instruction: What is the acronym for Fibrinolytic Therapy Trialists' (FTT) Collaborative Group?

Output: JAMA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Fibrinolytic Therapy Trialists' (FTT) Collaborative Group?. ### Response: JAMA.


Instruction: How many patients have been randomized to FTT trials?

Output: more than 1000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients have been randomized to FTT trials?. ### Response: more than 1000.


Instruction: What is the name of the randomized controlled trial of mechanical reperfusion in patients with acute myocardial infarction presenting more than 12 hours from symptom onset?

Output: Fibrinolytic Therapy Trialists’ (FTT) Collaborative Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized controlled trial of mechanical reperfusion in patients with acute myocardial infarction presenting more than 12 hours from symptom onset?. ### Response: Fibrinolytic Therapy Trialists’ (FTT) Collaborative Group.


Instruction: When did the JAMA issue 293:2865–72.403?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the JAMA issue 293:2865–72.403?. ### Response: 2005.


Instruction: How long after the onset of symptoms does coronary intervention occur in ST-segment ele-vation myocardial infarction?

Output: 12 to 24 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after the onset of symptoms does coronary intervention occur in ST-segment ele-vation myocardial infarction?. ### Response: 12 to 24 hours.


Instruction: What is the name of the prospective national observational study?

Output: PLACS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective national observational study?. ### Response: PLACS.


Instruction: When was the Am J Cardiol 2011 107:501–8.404 published?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Am J Cardiol 2011 107:501–8.404 published?. ### Response: 2011.


Instruction: What did the APEX-AMI trial provide insights from?

Output: Non-culprit coronary arterypercutaneous coronary intervention during acute ST-segment elevationmyocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the APEX-AMI trial provide insights from?. ### Response: Non-culprit coronary arterypercutaneous coronary intervention during acute ST-segment elevationmyocardial infarction.


Instruction: What did Widimsky P, Holmes DR Jr. know about ST-elevation and multi-vessel disease?

Output: How to treat patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Widimsky P, Holmes DR Jr. know about ST-elevation and multi-vessel disease?. ### Response: How to treat patients.


Instruction: What is a major adverse cardiac event during long-term follow-up?

Output: A randomised trial of target-vesselversus multi-vessel revascularisation in ST-elevation myocardial infarc-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a major adverse cardiac event during long-term follow-up?. ### Response: A randomised trial of target-vesselversus multi-vessel revascularisation in ST-elevation myocardial infarc-tion.


Instruction: What is the difference between a target-vessel and revascularisation?

Output: major adverse cardiac events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between a target-vessel and revascularisation?. ### Response: major adverse cardiac events.


Instruction: How many patients present with ST-segment elevation myocardial infarction?

Output: 398

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients present with ST-segment elevation myocardial infarction?. ### Response: 398.


Instruction: What is multi-vessel disease in patients presenting with ST-segment elevation myo-cardial infarction?

Output: staged percutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is multi-vessel disease in patients presenting with ST-segment elevation myo-cardial infarction?. ### Response: staged percutaneous coronary intervention.


Instruction: What is the J Am CollCardiol. 2011;58:692–703.408.

Output: a pairwise and network meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the J Am CollCardiol. 2011;58:692–703.408.. ### Response: a pairwise and network meta-analysis.


Instruction: What are the results of the HORIZONS-AMI trial?

Output: Prognostic impact of stagedversus “one-time” multivessel percutaneous interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of the HORIZONS-AMI trial?. ### Response: Prognostic impact of stagedversus “one-time” multivessel percutaneous interventions.


Instruction: What was the name of the trial?

Output: HORIZONS-AMI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the trial?. ### Response: HORIZONS-AMI.


Instruction: When was the J Am CollCardiol 58:704-11.409?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am CollCardiol 58:704-11.409?. ### Response: 2011.


Instruction: What is the association of door-to-balloon time and mortality in patients admitted to hospital with ST elevation myo-cardial infarction?

Output: national cohort study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association of door-to-balloon time and mortality in patients admitted to hospital with ST elevation myo-cardial infarction?. ### Response: national cohort study.


Instruction: What is recommended to confirm the diagnosis of hypertension and for titration of BP-lowering medication in conjunction with telehealth counseling or clinical interventions?

Output: Out-of-office BP measurements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended to confirm the diagnosis of hypertension and for titration of BP-lowering medication in conjunction with telehealth counseling or clinical interventions?. ### Response: Out-of-office BP measurements.


Instruction: What is the Class 1, Level of Evidence: ASR?

Output: 47–50

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Class 1, Level of Evidence: ASR?. ### Response: 47–50.


Instruction: For adults with confirmed hypertension, what is the risk of 10% or more?

Output: 10-year ASCVD event

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For adults with confirmed hypertension, what is the risk of 10% or more?. ### Response: 10-year ASCVD event.


Instruction: What is the recommended BP target for CVD or 10-year ASCVD event risk of 10% or higher?

Output: less than 130/80 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommended BP target for CVD or 10-year ASCVD event risk of 10% or higher?. ### Response: less than 130/80 mm Hg.


Instruction: What is recommended for older adults with hypertension and a high burden of comorbidity and limited life span?

Output: clinical judgment, patient preference, and a team-based approach to assess risk/benefit are reasonable for decisions regarding intensity of BP lowering and choice of antihypertensive drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for older adults with hypertension and a high burden of comorbidity and limited life span?. ### Response: clinical judgment, patient preference, and a team-based approach to assess risk/benefit are reasonable for decisions regarding intensity of BP lowering and choice of antihypertensive drugs.


Instruction: What are reasonable for decisions regarding intensity of BP lowering and choice of antihypertensive drugs?

Output: clinical judgment, patient preference, and a team-based approach to assess risk/benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are reasonable for decisions regarding intensity of BP lowering and choice of antihypertensive drugs?. ### Response: clinical judgment, patient preference, and a team-based approach to assess risk/benefit.


Instruction: What is Class 2a, Level of Evidence: C-EO?

Output: antihypertensive drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Class 2a, Level of Evidence: C-EO?. ### Response: antihypertensive drugs.


Instruction: What is beneficial for identifying patients with undiagnosed or undertreated hypertension?

Output: Use of the EHR and patient registries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is beneficial for identifying patients with undiagnosed or undertreated hypertension?. ### Response: Use of the EHR and patient registries.


Instruction: What is recommended for noninstitutionalized ambulatory community dwelling adults?

Output: less than 130 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for noninstitutionalized ambulatory community dwelling adults?. ### Response: less than 130 mm Hg.


Instruction: What is recommended for noninstitutionalized ambulatory community-dwelling adults with an average SBP of 130 mm Hg or higher?

Output: less than 130 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for noninstitutionalized ambulatory community-dwelling adults with an average SBP of 130 mm Hg or higher?. ### Response: less than 130 mm Hg.


Instruction: What should be evaluated by or referred to a primary care provider within 1 month of diagnosis?

Output: Adults with stage 2 hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be evaluated by or referred to a primary care provider within 1 month of diagnosis?. ### Response: Adults with stage 2 hypertension.


Instruction: How long does it take for a patient to be referred to a primary care provider?

Output: 1 month

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take for a patient to be referred to a primary care provider?. ### Response: 1 month.


Instruction: How many agents of different classes are used in nonpharmacological and antihypertensive drug therapy?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many agents of different classes are used in nonpharmacological and antihypertensive drug therapy?. ### Response: 2.


Instruction: In adults with an untreated BP, what is the class of evidence?

Output: Class 2a

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In adults with an untreated BP, what is the class of evidence?. ### Response: Class 2a.


Instruction: What is the level of evidence for white coat hypertension?

Output: B-NR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the level of evidence for white coat hypertension?. ### Response: B-NR.


Instruction: What is it reasonable to screen for in adults with an untreated SBP greater than 130 mm Hg?

Output: the presence of white coat hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is it reasonable to screen for in adults with an untreated SBP greater than 130 mm Hg?. ### Response: the presence of white coat hypertension.


Instruction: What type of hypertension can be detected by daytime ABPM or HBPM?

Output: white coat

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of hypertension can be detected by daytime ABPM or HBPM?. ### Response: white coat.


Instruction: What is the class of evidence for white coat hypertension?

Output: Class 2a

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the class of evidence for white coat hypertension?. ### Response: Class 2a.


Instruction: What is the acronym for the American Heart Association?

Output: AHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the American Heart Association?. ### Response: AHA.


Instruction: What is another name for the PCPI?

Output: Physician Consortium for Performance Improvement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for the PCPI?. ### Response: Physician Consortium for Performance Improvement.


Instruction: What is the member numerator compliant if the BP is 140/90 mm Hg?

Output: B-RSR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the member numerator compliant if the BP is 140/90 mm Hg?. ### Response: B-RSR.


Instruction: What happens if there is no BP reading during the measurement year or the reading is incomplete?

Output: The member is not compliant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What happens if there is no BP reading during the measurement year or the reading is incomplete?. ### Response: The member is not compliant.


Instruction: What indicates ambulatory blood pressure monitoring?

Output: ABPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates ambulatory blood pressure monitoring?. ### Response: ABPM.


Instruction: What does ACC stand for?

Output: American College of Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ACC stand for?. ### Response: American College of Cardiology.


Instruction: What is the acronym for ambulatory blood pressure monitoring?

Output: ABPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for ambulatory blood pressure monitoring?. ### Response: ABPM.


Instruction: What does AHA stand for?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does AHA stand for?. ### Response: American Heart Association.


Instruction: What is the 2015 ACC/AHA/HRS SVT Guideline e5213.1?

Output: Page et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2015 ACC/AHA/HRS SVT Guideline e5213.1?. ### Response: Page et al.


Instruction: What is regarded as physiological when it is the result of appropriate autonomic influences?

Output: Physiological Sinus TachycardiaSinus tachycardia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is regarded as physiological when it is the result of appropriate autonomic influences?. ### Response: Physiological Sinus TachycardiaSinus tachycardia.


Instruction: What are some of the pathological causes of tachycardia?

Output: infection with fever, dehydration, anemia, heart failure, and hyperthyroidism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the pathological causes of tachycardia?. ### Response: infection with fever, dehydration, anemia, heart failure, and hyperthyroidism.


Instruction: What is an example of a drug that has a beta-agonist effect?

Output: alb-uterol, salmeterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a drug that has a beta-agonist effect?. ### Response: alb-uterol, salmeterol.


Instruction: Along with cocaine and amphetamines, what is an illicit stimulant drug?

Output: meterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Along with cocaine and amphetamines, what is an illicit stimulant drug?. ### Response: meterol.


Instruction: What is expected to resolve with correction of the underlying cause?

Output: tachycardia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is expected to resolve with correction of the underlying cause?. ### Response: tachycardia.


Instruction: What is inappropriate sinus tachycardia?

Output: unexplained by physiological demands at rest, with minimal exertion, or during recovery from exercise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is inappropriate sinus tachycardia?. ### Response: unexplained by physiological demands at rest, with minimal exertion, or during recovery from exercise.


Instruction: What are some debilitating symptoms of IST?

Output: weakness, fatigue, lightheadedness, and uncomfortable sensations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some debilitating symptoms of IST?. ### Response: weakness, fatigue, lightheadedness, and uncomfortable sensations.


Instruction: Patients with IST typically show resting heart rates >100 bpm and average rates that are >90 bPM in a 24-hour period?

Output: 160

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with IST typically show resting heart rates >100 bpm and average rates that are >90 bPM in a 24-hour period?. ### Response: 160.


Instruction: What is the cause of IST?

Output: unclear

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cause of IST?. ### Response: unclear.


Instruction: What have been proposed mechanisms related to?

Output: dysautonomia, neurohormonal dysregulation, and intrinsic sinus node hyperactivity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have been proposed mechanisms related to?. ### Response: dysautonomia, neurohormonal dysregulation, and intrinsic sinus node hyperactivity.


Instruction: Why is it important to distinguish IST from secondary causes?

Output: The cause of IST is unclear

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is it important to distinguish IST from secondary causes?. ### Response: The cause of IST is unclear.


Instruction: What is an important trigger for IST patients?

Output: Anxiety

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an important trigger for IST patients?. ### Response: Anxiety.


Instruction: What type of heart disease must also be excluded?

Output: Structural

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of heart disease must also be excluded?. ### Response: Structural.


Instruction: Cardiomyopathies, such as cardiomyopathy, must be excluded, though the development of what is extremely rare?

Output: a cardiomyopathy secondary to sinus tachycardia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cardiomyopathies, such as cardiomyopathy, must be excluded, though the development of what is extremely rare?. ### Response: a cardiomyopathy secondary to sinus tachycardia.


Instruction: What is extremely rare?

Output: the development of a cardiomyopathy secondary to sinus tachycardia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is extremely rare?. ### Response: the development of a cardiomyopathy secondary to sinus tachycardia.


Instruction: IST must be distinguished from other forms of what?

Output: tachycardia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: IST must be distinguished from other forms of what?. ### Response: tachycardia.


Instruction: AT arising from the superior aspect of the crista terminalis and sinus node reentrant tachycardia (Section 4).

Output: IST

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: AT arising from the superior aspect of the crista terminalis and sinus node reentrant tachycardia (Section 4).. ### Response: IST.


Instruction: What is IST a diagnosis of?

Output: Inappropriate sinus tachycardia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is IST a diagnosis of?. ### Response: Inappropriate sinus tachycardia.


Instruction: What may overlap be present within an individual?

Output: postural ortho-static tachycardia syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may overlap be present within an individual?. ### Response: postural ortho-static tachycardia syndrome.


Instruction: What is there no specific recommendations for for acute treatment of IST?

Output: Acute Treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is there no specific recommendations for for acute treatment of IST?. ### Response: Acute Treatment.


Instruction: What is needed to treat narrow QRS tachycar -dia?

Output: Differential diagnosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed to treat narrow QRS tachycar -dia?. ### Response: Differential diagnosis.


Instruction: What is a differential diagnosis for?

Output: adult narrow QRS tachycar -dia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a differential diagnosis for?. ### Response: adult narrow QRS tachycar -dia.


Instruction: Patients with junctional tatchycardia may mimic what?

Output: pat-

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with junctional tatchycardia may mimic what?. ### Response: pat-.


Instruction: What is secondary prevention after CABG 953 63?

Output: Kulik et al  Secondary Prevention After CABG  953 63. Ibrahim K, Tjomsland O, Halvorsen D, Wiseth R, Wahba A, Karevold A, Haaverstad R. Effect of clopidogrel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is secondary prevention after CABG 953 63?. ### Response: Kulik et al  Secondary Prevention After CABG  953 63. Ibrahim K, Tjomsland O, Halvorsen D, Wiseth R, Wahba A, Karevold A, Haaverstad R. Effect of clopidogrel.


Instruction: What is clopidogrel's effect on midterm graft patency fol-lowing off-pump coronary revascularization surgery?

Output: improves mid-term outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is clopidogrel's effect on midterm graft patency fol-lowing off-pump coronary revascularization surgery?. ### Response: improves mid-term outcome.


Instruction: When did Heart Surg Forum. 2006;9:E581–E856?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Heart Surg Forum. 2006;9:E581–E856?. ### Response: 2006.


Instruction: What does clopidogrel do after off-pump coronary artery bypass graft surgery?

Output: improves mid-term outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does clopidogrel do after off-pump coronary artery bypass graft surgery?. ### Response: improves mid-term outcome.


Instruction: What is the name of the prospective study that evaluated postoperative coagulability and platelet inhibition after OPCAB?

Output: CRYSSA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective study that evaluated postoperative coagulability and platelet inhibition after OPCAB?. ### Response: CRYSSA.


Instruction: What is clopidogrel used for after OPCAB?

Output: Hypercoagulability and platelet inhibition

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is clopidogrel used for after OPCAB?. ### Response: Hypercoagulability and platelet inhibition.


Instruction: What is the name of the randomized intervention?

Output: CRYSSA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized intervention?. ### Response: CRYSSA.


Instruction: When was the Scand Cardiovasc J41:325-330?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Scand Cardiovasc J41:325-330?. ### Response: 2007.


Instruction: What is CRYSSA?

Output: prevention of Coronary arteRY bypaSS occlusion After off-pump procedures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CRYSSA?. ### Response: prevention of Coronary arteRY bypaSS occlusion After off-pump procedures.


Instruction: What is the name of the randomised study that showed platelet inhibition after off-pump coronary artery bypass surgery?

Output: CRYSSA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised study that showed platelet inhibition after off-pump coronary artery bypass surgery?. ### Response: CRYSSA.


Instruction: What is the name of the prospective, randomized study of aortocoronary bypass surgery?

Output: CRYSSA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective, randomized study of aortocoronary bypass surgery?. ### Response: CRYSSA.


Instruction: What was the effect of aggressive lowering of low-density lipoprotein cholesterol levels and low-dose anticoagulation on saphenous-vein coronary-artery changes?

Output: obstructive changes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the effect of aggressive lowering of low-density lipoprotein cholesterol levels and low-dose anticoagulation on saphenous-vein coronary-artery changes?. ### Response: obstructive changes.


Instruction: What is the effect of low-dose anticoagulation on obstructive changes in saphenous-vein coronary-artery bypass grafts?

Output: Improved graft patency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of low-dose anticoagulation on obstructive changes in saphenous-vein coronary-artery bypass grafts?. ### Response: Improved graft patency.


Instruction: What is Wann LS, Curtis AB, January CT, Ellenbogen KA, Lowe JE, Estes NA 3rd, Page RL, Ezekowitz MD, Slotwiner DJ, Jackman WM, Stevenson WG, Fuster V, Rydén LE, Cannom DS?

Output: 69

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Wann LS, Curtis AB, January CT, Ellenbogen KA, Lowe JE, Estes NA 3rd, Page RL, Ezekowitz MD, Slotwiner DJ, Jackman WM, Stevenson WG, Fuster V, Rydén LE, Cannom DS?. ### Response: 69.


Instruction: What is the name of the person who is a member of the WG?

Output: Stevenson

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the person who is a member of the WG?. ### Response: Stevenson.


Instruction: What is another name for the person whose name is associated with Tracy CM?

Output: Fuster V

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for the person whose name is associated with Tracy CM?. ### Response: Fuster V.


Instruction: Who is the other person who has a similar name?

Output: Yancy CW

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the other person who has a similar name?. ### Response: Yancy CW.


Instruction: Which of the following are the names of the people who have similar names?

Output: Ellenbogen KA, Prystowsky EN, Halperin JL, Tamargo JL, Kay GN, Wann L, Jacobs AK, Anderson JL, Albert N, Hochman JS, Buller CE, Kushner FG, Creager MA, Ohman EM, Ettinger SM, Stevenson WG, Guyton RA, Tarkington LG, Halperin JL, Yancy CW

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which of the following are the names of the people who have similar names?. ### Response: Ellenbogen KA, Prystowsky EN, Halperin JL, Tamargo JL, Kay GN, Wann L, Jacobs AK, Anderson JL, Albert N, Hochman JS, Buller CE, Kushner FG, Creager MA, Ohman EM, Ettinger SM, Stevenson WG, Guyton RA, Tarkington LG, Halperin JL, Yancy CW.


Instruction: Who wrote the 2011 ACCF/AHA/HRS focused update on the management of patients with atrial fibril-lation?

Output: American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote the 2011 ACCF/AHA/HRS focused update on the management of patients with atrial fibril-lation?. ### Response: American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.


Instruction: What was the 2006 guideline updated to?

Output: management of patients with atrial fibril-lation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 2006 guideline updated to?. ### Response: management of patients with atrial fibril-lation.


Instruction: What is the acronym for the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines?

Output: ACCF/AHA Task Force Members. 2011 ACCF/AHA/HRS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines?. ### Response: ACCF/AHA Task Force Members. 2011 ACCF/AHA/HRS.


Instruction: When was the Circulation. 2011;123:104-123?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circulation. 2011;123:104-123?. ### Response: 2011.


Instruction: Who is the Executive Summary of the American Collegiate of Chest Physicians Antithrombotic Therapy and Prevention of Thrombosis Panel?

Output: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Executive Summary of the American Collegiate of Chest Physicians Antithrombotic Therapy and Prevention of Thrombosis Panel?. ### Response: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.


Instruction: What is the 9th ed of the American College of Chest Physicians Evidence-Based Clinical Practice Guidelines?

Output: Antithrombotic Therapy and Prevention of Thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 9th ed of the American College of Chest Physicians Evidence-Based Clinical Practice Guidelines?. ### Response: Antithrombotic Therapy and Prevention of Thrombosis.


Instruction: What type of patient needs help to arrive at a management decision consistent with her or his values and preferences?

Output: Each patient

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of patient needs help to arrive at a management decision consistent with her or his values and preferences?. ### Response: Each patient.


Instruction: What is likely to requiresubstantial debate and involvement of stakeholders before policy can be determined?

Output: The recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is likely to requiresubstantial debate and involvement of stakeholders before policy can be determined?. ### Response: The recommendation.


Instruction: The additional category ‘Not Graded’ was used to provide guidance based on what?

Output: common sense

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The additional category ‘Not Graded’ was used to provide guidance based on what?. ### Response: common sense.


Instruction: What are the most common examples of recommendations regarding monitoring intervals?

Output: counseling, and referral to other clinical specialists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the most common examples of recommendations regarding monitoring intervals?. ### Response: counseling, and referral to other clinical specialists.


Instruction: What are recommendations written as?

Output: simple declarative statements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are recommendations written as?. ### Response: simple declarative statements.


Instruction: What are declarative statements not meant to be interpreted as being stronger recommendations than Level 1 or 2 recomendations?

Output: ung raded recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are declarative statements not meant to be interpreted as being stronger recommendations than Level 1 or 2 recomendations?. ### Response: ung raded recommendations.


Instruction: What is the larger the difference between thedesirable and undesirable effects, the more likely a strong recommendation is?

Output: warranted

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the larger the difference between thedesirable and undesirable effects, the more likely a strong recommendation is?. ### Response: warranted.


Instruction: The narrower the gradient, the more likely a weak recommendation iswarranted.

Output: C Low

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The narrower the gradient, the more likely a weak recommendation iswarranted.. ### Response: C Low.


Instruction: The higher the quality of evidence, themore likely what is warranted?

Output: a strong recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The higher the quality of evidence, themore likely what is warranted?. ### Response: a strong recommendation.


Instruction: The more variability in values and preferences or the more uncertainty invalues and preferences make a recommendation more likely what?

Output: aweak recommendation is warranted

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The more variability in values and preferences or the more uncertainty invalues and preferences make a recommendation more likely what?. ### Response: aweak recommendation is warranted.


Instruction: The more uncertainty invalues and preferences, the more likely aweak recommendation is warranted?

Output: strong

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The more uncertainty invalues and preferences, the more likely aweak recommendation is warranted?. ### Response: strong.


Instruction: What is cost (resource allocation)?

Output: The higher the costs of an intervention—that is, the more resources consumed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is cost (resource allocation)?. ### Response: The higher the costs of an intervention—that is, the more resources consumed.


Instruction: The higher the costs of an intervention, the less likely is a strong recommendation iswarranted?

Output: Very low

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The higher the costs of an intervention, the less likely is a strong recommendation iswarranted?. ### Response: Very low.


Instruction: What was evidence used to determine the balance of medical benefits and harms of an intervention to a patient?

Output: Table 13

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was evidence used to determine the balance of medical benefits and harms of an intervention to a patient?. ### Response: Table 13.


Instruction: What was a non- statistically significant benefit or harm of drug X?

Output: possiblebenefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a non- statistically significant benefit or harm of drug X?. ### Response: possiblebenefit.


Instruction: What can be reported if a study is not imprecise?

Output: No difference

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be reported if a study is not imprecise?. ### Response: No difference.


Instruction: What is the final grade for overall quality of evidence?

Output: A High

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the final grade for overall quality of evidence?. ### Response: A High.


Instruction: High We are confident that the true effect lies close towhat?

Output: that of the estimate of the effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: High We are confident that the true effect lies close towhat?. ### Response: that of the estimate of the effect.


Instruction: Moderate The true effect is likely to be close to what?

Output: the estimateof the effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Moderate The true effect is likely to be close to what?. ### Response: the estimateof the effect.


Instruction: What may be substantially different from the estimate of the effect?

Output: The true effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be substantially different from the estimate of the effect?. ### Response: The true effect.


Instruction: What is very low The estimate of effect is very uncertain and often far from the truth?

Output: D

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is very low The estimate of effect is very uncertain and often far from the truth?. ### Response: D.


Instruction: What is the High Blood Pressure Clinical Practice Guideline e519.2.2?

Output: Heart Failure With Preserved Ejection Fraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the High Blood Pressure Clinical Practice Guideline e519.2.2?. ### Response: Heart Failure With Preserved Ejection Fraction.


Instruction: What are the References that support recommendations summarized in?

Output: Online Data Supplements 35 and 36.COR LOE RecommendationsI C-EO1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the References that support recommendations summarized in?. ### Response: Online Data Supplements 35 and 36.COR LOE RecommendationsI C-EO1.


Instruction: In adults with HFp EF who present, what are the Recommendations?

Output: Obesity, CHD, DM, AF, and hyperlipidemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In adults with HFp EF who present, what are the Recommendations?. ### Response: Obesity, CHD, DM, AF, and hyperlipidemia.


Instruction: What should be prescribed to adults with HFp EF who present with symptoms of volume overload?

Output: diuretics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be prescribed to adults with HFp EF who present with symptoms of volume overload?. ### Response: diuretics.


Instruction: What percentage of patients with HF have HFpEF?

Output: 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients with HF have HFpEF?. ### Response: 50%.


Instruction: What is the ejection fraction in these studies?

Output: >40% to ≥ 55%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ejection fraction in these studies?. ### Response: >40% to ≥ 55%..


Instruction: What is the most important cause of HFp EF?

Output: Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most important cause of HFp EF?. ### Response: Hypertension.


Instruction: What is a prevalence of 60% to 89% in large RCTs?

Output: Hypertension is the most important cause of HFp EF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a prevalence of 60% to 89% in large RCTs?. ### Response: Hypertension is the most important cause of HFp EF.


Instruction: What is an expression of HFpEF?

Output: Hypertensive acute pulmonary edema

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an expression of HFpEF?. ### Response: Hypertensive acute pulmonary edema.


Instruction: What is important for prevention?

Output: HFpEF.S9.2.2-15BP control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is important for prevention?. ### Response: HFpEF.S9.2.2-15BP control.


Instruction: How did ALLHAT show that treatment of hypertension with chlorthalidone reduced?

Output: the risk of HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did ALLHAT show that treatment of hypertension with chlorthalidone reduced?. ### Response: the risk of HF.


Instruction: What drug did ALLHAT show reduced the risk of HF?

Output: chlorthalidone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug did ALLHAT show reduced the risk of HF?. ### Response: chlorthalidone.


Instruction: What is the only drug used for the treatment of hypertension and HF that can adequately control the fluid?

Output: Diuretics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the only drug used for the treatment of hypertension and HF that can adequately control the fluid?. ### Response: Diuretics.


Instruction: What is crucial to the success of other drugs used for the treatment of hypertension in the presence of HF?

Output: Appropriate use of diuretics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is crucial to the success of other drugs used for the treatment of hypertension in the presence of HF?. ### Response: Appropriate use of diuretics.


Instruction: What can the use of inappropriately low doses of diuretics result in?

Output: fluid retention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can the use of inappropriately low doses of diuretics result in?. ### Response: fluid retention.


Instruction: What can inappropriately low doses of diuretics result in?

Output: fluid retention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can inappropriately low doses of diuretics result in?. ### Response: fluid retention.


Instruction: What can the use of inap-propriately high doses lead to?

Output: volume contraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can the use of inap-propriately high doses lead to?. ### Response: volume contraction.


Instruction: Diuretics should be prescribed to all patients with what type of hypertension?

Output: hypertension and HFp EF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Diuretics should be prescribed to all patients with what type of hypertension?. ### Response: hypertension and HFp EF.


Instruction: What type of patients have evidence of fluid retention?

Output: hypertension and HFp EF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of patients have evidence of fluid retention?. ### Response: hypertension and HFp EF.


Instruction: How much reduction in mortality did patients with HFp EF and MI have at 32-month follow-up?

Output: 35%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much reduction in mortality did patients with HFp EF and MI have at 32-month follow-up?. ### Response: 35%.


Instruction: What did patients who ran-domized to propranolol have?

Output: a 35% reduction in mortality rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did patients who ran-domized to propranolol have?. ### Response: a 35% reduction in mortality rate.


Instruction: How much reduction in mortality rate did nebivolol have in patients with HFrEF and HFp EF?

Output: 35%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much reduction in mortality rate did nebivolol have in patients with HFrEF and HFp EF?. ### Response: 35%.


Instruction: What was the reduction in CVD hospitalization in patients randomized to NEBIVOLOl?

Output: 14%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the reduction in CVD hospitalization in patients randomized to NEBIVOLOl?. ### Response: 14%.


Instruction: How long was the treatment of HFRP EF patients compared with placebo?

Output: 21 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the treatment of HFRP EF patients compared with placebo?. ### Response: 21 months.


Instruction: What is the primary outcome in patients with HFp EF?

Output: Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary outcome in patients with HFp EF?. ### Response: Hypertension.


Instruction: Bozkurt et alDecember 6, 2016 Circulation. 2016;134:e535–e578 What is the DOI: 10.1161/CIR.0000000000000450 e566?

Output: 10.1161/01.cir.0000437739.71477

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Bozkurt et alDecember 6, 2016 Circulation. 2016;134:e535–e578 What is the DOI: 10.1161/CIR.0000000000000450 e566?. ### Response: 10.1161/01.cir.0000437739.71477.


Instruction: Be, Nonas CA, Pi-Sunyer FX, Ste-vens J, Stevens VJ, Wadden TA, Wolfe BM, Yanovski SZ, Jordan HS, Kendall KA, Lux LJ, Mentor-Marcel R, Morgan LC, Trisolini MG, Morgan-LC, Halperin JL, Albert NM, Bozkurt B, Brindis RG, Curtis LH, Hochman JS, Kovacs RJ, Ohman EM, Pressler

Output: Millen BE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Be, Nonas CA, Pi-Sunyer FX, Ste-vens J, Stevens VJ, Wadden TA, Wolfe BM, Yanovski SZ, Jordan HS, Kendall KA, Lux LJ, Mentor-Marcel R, Morgan LC, Trisolini MG, Morgan-LC, Halperin JL, Albert NM, Bozkurt B, Brindis RG, Curtis LH, Hochman JS, Kovacs RJ, Ohman EM, Pressler. ### Response: Millen BE.


Instruction: What is the 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults?

Output: 2013 A

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults?. ### Response: 2013 A.


Instruction: What is a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines?

Output: 2013 ACCF/AHA guideline for the management of heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines?. ### Response: 2013 ACCF/AHA guideline for the management of heart failure.


Instruction: What is the name of the Task Force on Practice Guidelines?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Practice Guidelines?. ### Response: American Heart Association.


Instruction: Who is the Obesity Society?

Output: American Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Obesity Society?. ### Response: American Heart Association Task Force on Practice Guidelines.


Instruction: What does Circulation do?

Output: con-sensus panel guide to comprehensive risk reduction for adult patients without coronary or other atherosclerotic vascular diseases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Circulation do?. ### Response: con-sensus panel guide to comprehensive risk reduction for adult patients without coronary or other atherosclerotic vascular diseases.


Instruction: What is the Eighth Joint National Committee called?

Output: JNC 8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Eighth Joint National Committee called?. ### Response: JNC 8.


Instruction: What does JNC 8 stand for?

Output: Joint National Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does JNC 8 stand for?. ### Response: Joint National Committee.


Instruction: What is JNC 8?

Output: Eighth Joint National Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is JNC 8?. ### Response: Eighth Joint National Committee.


Instruction: When was the published correction in JAMA?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the published correction in JAMA?. ### Response: 2014.


Instruction: What is the doi for JAMA.2013.284427?

Output: 10.1001

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the doi for JAMA.2013.284427?. ### Response: 10.1001.


Instruction: Who is the author of JNC 8)?

Output: Ortiz

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of JNC 8)?. ### Response: Ortiz.


Instruction: What is the 2013 ACCF/AHA guideline for the management of heart failure?

Output: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2013 ACCF/AHA guideline for the management of heart failure?. ### Response: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines.


Instruction: What is a report of the American College of Cardiology Foundation/American Heart Association Task Force on?

Output: practice guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a report of the American College of Cardiology Foundation/American Heart Association Task Force on?. ### Response: practice guidelines.


Instruction: What is the focus of the Heart Association Task Force on practice guidelines?

Output: comprehensive risk reduction for adult patients without coronary or other atherosclerotic vascular diseases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the focus of the Heart Association Task Force on practice guidelines?. ### Response: comprehensive risk reduction for adult patients without coronary or other atherosclerotic vascular diseases.


Instruction: Circulation 2013;128:e240–e319. doi: 10.1161/CIR.0b013e31829e8776.

Output: 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation 2013;128:e240–e319. doi: 10.1161/CIR.0b013e31829e8776.. ### Response: 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines.


Instruction: What is a con-sensus panel guide to comprehensive risk reduction for adult patients without coronary or other atherosclerotic vascular diseases?

Output: AHA guidelines for primary preven-tion of cardiovascular disease and stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a con-sensus panel guide to comprehensive risk reduction for adult patients without coronary or other atherosclerotic vascular diseases?. ### Response: AHA guidelines for primary preven-tion of cardiovascular disease and stroke.


Instruction: What is the current AHA guidelines for primary preven-tion of cardiovascular disease and stroke?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the current AHA guidelines for primary preven-tion of cardiovascular disease and stroke?. ### Response: 2002.


Instruction: What is Circulation. 2002;106:388–391. doi: 10.1161/01.CIR.0000020190.45892.75. Lichtenstein AH, Appel LJ, Brands M, Carnethon M, Harris WS, Howard B, Karanja N, Lefevre M, Rudel L, Sacks F, Van Horn L, Winston M, Wylie-Rosett J. Diet and lifestyle recommendations revision 2006: a scientific statement?

Output: AHA guidelines for primary preven-tion of cardiovascular disease and stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Circulation. 2002;106:388–391. doi: 10.1161/01.CIR.0000020190.45892.75. Lichtenstein AH, Appel LJ, Brands M, Carnethon M, Harris WS, Howard B, Karanja N, Lefevre M, Rudel L, Sacks F, Van Horn L, Winston M, Wylie-Rosett J. Diet and lifestyle recommendations revision 2006: a scientific statement?. ### Response: AHA guidelines for primary preven-tion of cardiovascular disease and stroke.


Instruction: What is a scientific statement from the American Heart Association Nu-trition Committee?

Output: Diet and lifestyle recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a scientific statement from the American Heart Association Nu-trition Committee?. ### Response: Diet and lifestyle recommendations.


Instruction: Circulation. 2006;114:e27 and 2006:e629 include what corrections?

Output: published corrections

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation. 2006;114:e27 and 2006:e629 include what corrections?. ### Response: published corrections.


Instruction: What is the short title of the PM-11: Acute STEMI: Time From FMC to Primary PCI at STEMI Receiving Facility among Transferred Patients?

Output: AHA/ACC STEMI/NSTEMI Measure Set

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the short title of the PM-11: Acute STEMI: Time From FMC to Primary PCI at STEMI Receiving Facility among Transferred Patients?. ### Response: AHA/ACC STEMI/NSTEMI Measure Set.


Instruction: What is the median time from FMC to primary PCI at the STEMI receiving facility?

Output: ≤120 min

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the median time from FMC to primary PCI at the STEMI receiving facility?. ### Response: ≤120 min.


Instruction: How long is the STEMI receiving facility?

Output: ≤120 min

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the STEMI receiving facility?. ### Response: ≤120 min.


Instruction: What is the term for a PCI-capable hospital?

Output: STEMI receiving facility

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for a PCI-capable hospital?. ### Response: STEMI receiving facility.


Instruction: Patients with STEMI are defined by characteristic symptoms of what?

Output: myocardial ischemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with STEMI are defined by characteristic symptoms of what?. ### Response: myocardial ischemia.


Instruction: How long from FMC*Patients with STEMI equivalent on ECG may have: hyperacute T-wave changes, true posterior MI, multilead ST depression with coexistent ST elevation in lead aVR, characteristic diagnostic criteria in the setting of what?

Output: LBBB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long from FMC*Patients with STEMI equivalent on ECG may have: hyperacute T-wave changes, true posterior MI, multilead ST depression with coexistent ST elevation in lead aVR, characteristic diagnostic criteria in the setting of what?. ### Response: LBBB.


Instruction: Where are PCI-capable patients initially seen?

Output: STEMI receiving facility

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are PCI-capable patients initially seen?. ### Response: STEMI receiving facility.


Instruction: Where are patients transferred for a PCI that is described as nonprimary by a healthcare provider?

Output: Patients age <18 yPatients who are transferred for a PCI that is described as nonprimary by a healthcare provider (eg, patients who receive fibrinolytic therapy at the referral facility

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are patients transferred for a PCI that is described as nonprimary by a healthcare provider?. ### Response: Patients age <18 yPatients who are transferred for a PCI that is described as nonprimary by a healthcare provider (eg, patients who receive fibrinolytic therapy at the referral facility.


Instruction: Patients who receive fibrinolytic therapy at home are considered to be what?

Output: individual

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients who receive fibrinolytic therapy at home are considered to be what?. ### Response: individual.


Instruction: What is the primary reperfusion therapy for fibrinolytic therapy?

Output: referral facility

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary reperfusion therapy for fibrinolytic therapy?. ### Response: referral facility.


Instruction: What is a medical reason for the delay?

Output: cardiopulmonary arrest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a medical reason for the delay?. ### Response: cardiopulmonary arrest.


Instruction: What is the reason for the delay?

Output: initial patient concern

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the reason for the delay?. ### Response: initial patient concern.


Instruction: What is another term for STEMI and reperfusion?

Output: therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for STEMI and reperfusion?. ### Response: therapy.


Instruction: What are referral facility and STEMI receiving facility accountable for?

Output: Attribution Measure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are referral facility and STEMI receiving facility accountable for?. ### Response: Attribution Measure.


Instruction: What is improved if patients can be quickly transferred to a PCI-capable hospital for primary PCI?

Output: Patient outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is improved if patients can be quickly transferred to a PCI-capable hospital for primary PCI?. ### Response: Patient outcome.


Instruction: What is the 2013 ACCF/AHA Guideline for the Management of Patients With ST-Elevation Myocardial Infarction121?

Output: Clinical Recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2013 ACCF/AHA Guideline for the Management of Patients With ST-Elevation Myocardial Infarction121?. ### Response: Clinical Recommendation.


Instruction: What is a recommended triage strategy for patients with STEMI who arrive at or are transported to a non-PCI-capable hospital?

Output: Immediate transfer to a PCI-capable hospital for primary PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a recommended triage strategy for patients with STEMI who arrive at or are transported to a non-PCI-capable hospital?. ### Response: Immediate transfer to a PCI-capable hospital for primary PCI.


Instruction: How long is the FMC-to-device time system goal?

Output: 120 minutes or less

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the FMC-to-device time system goal?. ### Response: 120 minutes or less.


Instruction: What is the class I, Level of Evidence: B?

Output: PCI-capable hospital for primary PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the class I, Level of Evidence: B?. ### Response: PCI-capable hospital for primary PCI.


Instruction: What are routine of fice BP measurements generally higher than?

Output: standardized of ﬁce BP measurements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are routine of fice BP measurements generally higher than?. ### Response: standardized of ﬁce BP measurements.


Instruction: What could overtreatment of BP lead to?

Output: routine, non-standardized of ﬁce BP measurements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could overtreatment of BP lead to?. ### Response: routine, non-standardized of ﬁce BP measurements.


Instruction: What does routine of fice BP lead to?

Output: undertreatment ofhigh BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does routine of fice BP lead to?. ### Response: undertreatment ofhigh BP.


Instruction: What is a higher risk of future cardiovascular events?

Output: high BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a higher risk of future cardiovascular events?. ### Response: high BP.


Instruction: What is it not possible to convert a routine of fice BP into?

Output: astandardized of ﬁce BP using a correction factor in an individual

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is it not possible to convert a routine of fice BP into?. ### Response: astandardized of ﬁce BP using a correction factor in an individual.


Instruction: What would most well-informedpatients accept the additional time required for?

Output: stan-dardized of ﬁce BP measurement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would most well-informedpatients accept the additional time required for?. ### Response: stan-dardized of ﬁce BP measurement.


Instruction: What does standardized of fice BP not necessarily require beyond the existingBP measurement devices?

Output: additional equipment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does standardized of fice BP not necessarily require beyond the existingBP measurement devices?. ### Response: additional equipment.


Instruction: What is the need to follow proper preparatory procedures?

Output: longer to perform than routine of ﬁce BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the need to follow proper preparatory procedures?. ### Response: longer to perform than routine of ﬁce BP.


Instruction: What does BP need to follow?

Output: proper preparatory procedures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does BP need to follow?. ### Response: proper preparatory procedures.


Instruction: What may be an increased time burden on patients, providers, and staff?

Output: standardized of ﬁce BPtakes longer to perform than routine of ﬁce BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be an increased time burden on patients, providers, and staff?. ### Response: standardized of ﬁce BPtakes longer to perform than routine of ﬁce BP.


Instruction: What may be an issue in certain settings?

Output: Adequate access to a quiet clinic spacethat allows for an adequate rest period prior to BP mea-surement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be an issue in certain settings?. ### Response: Adequate access to a quiet clinic spacethat allows for an adequate rest period prior to BP mea-surement.


Instruction: What is likely to be cost-effective as it may avert consequences of over- and undertreatment?

Output: this recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is likely to be cost-effective as it may avert consequences of over- and undertreatment?. ### Response: this recommendation.


Instruction: What may avert consequences of over-treatment and undertreatment?

Output: this recommendation is likelyto be cost-effective

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may avert consequences of over-treatment and undertreatment?. ### Response: this recommendation is likelyto be cost-effective.


Instruction: The use of standardizedoffice BP over routine of fice BP holds true for all patients?

Output: regardless of age, sex, race, or CKD severity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The use of standardizedoffice BP over routine of fice BP holds true for all patients?. ### Response: regardless of age, sex, race, or CKD severity.


Instruction: What year was the KDIGO 2012 BP guideline added?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the KDIGO 2012 BP guideline added?. ### Response: 2012.


Instruction: What does this recommendation place a lower value on?

Output: increased timerequired to perform standardized BP measurements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does this recommendation place a lower value on?. ### Response: increased timerequired to perform standardized BP measurements.


Instruction: What is consistent with other recent guidelines that underscore the importance of standard-ized of fice BP measurement?

Output: recommendation places a lower value on the increased timerequired to perform standardized BP measurements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is consistent with other recent guidelines that underscore the importance of standard-ized of fice BP measurement?. ### Response: recommendation places a lower value on the increased timerequired to perform standardized BP measurements.


Instruction: What is the acronym for Car-diology?

Output: American College

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Car-diology?. ### Response: American College.


Instruction: What is another acronym for European Society of Cardiology?

Output: ESC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another acronym for European Society of Cardiology?. ### Response: ESC.


Instruction: An oscillometric BP device may be preferable to what?

Output: manual BP device

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: An oscillometric BP device may be preferable to what?. ### Response: manual BP device.


Instruction: What is CABG?

Output: coronary artery bypass graft

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CABG?. ### Response: coronary artery bypass graft.


Instruction: What is LAD?

Output: left anterior descending

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is LAD?. ### Response: left anterior descending.


Instruction: Where is PCI located?

Output: percutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is PCI located?. ### Response: percutaneous coronary intervention.


Instruction: When was the RCT released?

Output: May 1, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the RCT released?. ### Response: May 1, 2023.


Instruction: What was the date of the e452 Stroke?

Output: July 2021

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the date of the e452 Stroke?. ### Response: July 2021.


Instruction: What is the DOI of the 2021 Guideline for the Secondary Prevention of Ischemic Strokes 338?

Output: 10.1161/STR.0000000000000375CLINICAL STATEMENTS  AND GUIDELINESKleindorfer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the DOI of the 2021 Guideline for the Secondary Prevention of Ischemic Strokes 338?. ### Response: 10.1161/STR.0000000000000375CLINICAL STATEMENTS  AND GUIDELINESKleindorfer.


Instruction: Who are CHANCE Investigators?

Output: Liu L, Wong KS, Leng X, Pu Y, Wang Y, Jing J, Zou X, Pan Y, Wang A, Meng X, et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who are CHANCE Investigators?. ### Response: Liu L, Wong KS, Leng X, Pu Y, Wang Y, Jing J, Zou X, Pan Y, Wang A, Meng X, et al.


Instruction: What is the name of the study that investigated dual antiplatelet therapy in stroke and ICAS?

Output: CHANCE Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated dual antiplatelet therapy in stroke and ICAS?. ### Response: CHANCE Investigators.


Instruction: What are the names of the investigators of the CLAIR Study?

Output: Wong KS, Chen C, Fu J, Chang HM, Suwanwela NC, Huang YN, Han Z, Tan KS, Ratanakorn D, Chollate P, et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the investigators of the CLAIR Study?. ### Response: Wong KS, Chen C, Fu J, Chang HM, Suwanwela NC, Huang YN, Han Z, Tan KS, Ratanakorn D, Chollate P, et al.


Instruction: What is the name of the study that compares clopidogrel and aspirin?

Output: CATHARSIS Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that compares clopidogrel and aspirin?. ### Response: CATHARSIS Study Group.


Instruction: What was the outcome of the CLAIR study?

Output: blinded-endpoint trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome of the CLAIR study?. ### Response: blinded-endpoint trial.


Instruction: In what year did the Lancet Neurol publish a report on CLAIR?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did the Lancet Neurol publish a report on CLAIR?. ### Response: 2010.


Instruction: What is ticagrelor added to in acute nonse-vere stroke or transient ischemic attack of atherosclerotic origin?

Output: aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ticagrelor added to in acute nonse-vere stroke or transient ischemic attack of atherosclerotic origin?. ### Response: aspirin.


Instruction: Who is the THALES Steering Committee and Investigators?

Output: Amarenco P, Denison H, Evans SR, Himmelmann A, James S, Knutsson M, Ladenvall P, Molina CA, Wang Y, Johnston SC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the THALES Steering Committee and Investigators?. ### Response: Amarenco P, Denison H, Evans SR, Himmelmann A, James S, Knutsson M, Ladenvall P, Molina CA, Wang Y, Johnston SC.


Instruction: What prevents the progression of the symptomatic intracranial arterial stenosis?

Output: Cilostazol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What prevents the progression of the symptomatic intracranial arterial stenosis?. ### Response: Cilostazol.


Instruction: What does cilostazol prevent?

Output: the progression of the symptomatic intracranial arterial stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does cilostazol prevent?. ### Response: the progression of the symptomatic intracranial arterial stenosis.


Instruction: What is cilostazol used for in patients with symptomatic intracranial arterial stenosis?

Output: prevents the progression

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is cilostazol used for in patients with symptomatic intracranial arterial stenosis?. ### Response: prevents the progression.


Instruction: What is the name of the study that investigated the efficacy and safety of combination antiplatelet therapies?

Output: CATHARSIS Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the efficacy and safety of combination antiplatelet therapies?. ### Response: CATHARSIS Study Group.


Instruction: What is a symptomatic intracranial atherosclerotic stenosis?

Output: combination antiplatelet therapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a symptomatic intracranial atherosclerotic stenosis?. ### Response: combination antiplatelet therapies.


Instruction: What are the final results of Cilostazol-Aspirin Therapy against Recurrent Stroke with?

Output: Intracranial Artery Stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the final results of Cilostazol-Aspirin Therapy against Recurrent Stroke with?. ### Response: Intracranial Artery Stenosis.


Instruction: What is CATHARSIS?

Output: Cilostazol-Aspirin Therapy against Recurrent Stroke with Intracranial Artery Stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CATHARSIS?. ### Response: Cilostazol-Aspirin Therapy against Recurrent Stroke with Intracranial Artery Stenosis.


Instruction: What is Cilostazol-Aspirin Therapy against?

Output: Recurrent Stroke with Intracranial Artery Stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Cilostazol-Aspirin Therapy against?. ### Response: Recurrent Stroke with Intracranial Artery Stenosis.


Instruction: What is dual antiplatelet therapy using cilostazol for secondary prevention in patients with high-risk ischaemic stroke in Japan?

Output: a multicentre, open-label, randomised controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is dual antiplatelet therapy using cilostazol for secondary prevention in patients with high-risk ischaemic stroke in Japan?. ### Response: a multicentre, open-label, randomised controlled trial.


Instruction: What is the name of the multicentre, open-label, randomised controlled trial?

Output: com Trial Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multicentre, open-label, randomised controlled trial?. ### Response: com Trial Investigators.


Instruction: Who is the WASID Trial Investigator?

Output: Turan TN, Cotsonis G, Lynn MJ, Chaturvedi S, Chimowitz M; Warfarin-Aspirin Symptomatic Intracranial Disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the WASID Trial Investigator?. ### Response: Turan TN, Cotsonis G, Lynn MJ, Chaturvedi S, Chimowitz M; Warfarin-Aspirin Symptomatic Intracranial Disease.


Instruction: What is the relationship between blood pressure and stroke recurrence in patients with intracranial arterial stenosis?

Output: Relationship

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the relationship between blood pressure and stroke recurrence in patients with intracranial arterial stenosis?. ### Response: Relationship.


Instruction: Circulation. 2007;115:2969–2975. doi: 10.1161/CIRCULATIONAHA.106.622464 346.

Output: Relationship between blood pressure and stroke recurrence in patients with intracranial arterial stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation. 2007;115:2969–2975. doi: 10.1161/CIRCULATIONAHA.106.622464 346.. ### Response: Relationship between blood pressure and stroke recurrence in patients with intracranial arterial stenosis.


Instruction: How do adhesins attach to host cell structures or extracellular molecules?

Output: bind to host cells or to extracel-lular matrix

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do adhesins attach to host cell structures or extracellular molecules?. ### Response: bind to host cells or to extracel-lular matrix.


Instruction: What has been a pivotal aspect of pathogenesis investigations?

Output: The availability of an experimental animal model of endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been a pivotal aspect of pathogenesis investigations?. ### Response: The availability of an experimental animal model of endocarditis.


Instruction: What has served as the ultimate evaluation of in vitro molecular techniques?

Output: experimental animal model of endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has served as the ultimate evaluation of in vitro molecular techniques?. ### Response: experimental animal model of endocarditis.


Instruction: What are mutant and recombinant isolates developed to examine the effects of a single purported virulence factor expressed by a wild-type strain?

Output: in vitro molecular techniques

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are mutant and recombinant isolates developed to examine the effects of a single purported virulence factor expressed by a wild-type strain?. ### Response: in vitro molecular techniques.


Instruction: Gram-positive cocci typically express what?

Output: multiple adhesins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Gram-positive cocci typically express what?. ### Response: multiple adhesins.


Instruction: What type of cocci typically express multiple adhesins?

Output: Gram-positive

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of cocci typically express multiple adhesins?. ### Response: Gram-positive.


Instruction: What is remarkable about the ability to demonstrate the role of a single adhesion in infection pathogenesis?

Output: pilus involvement in attachment to collagen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is remarkable about the ability to demonstrate the role of a single adhesion in infection pathogenesis?. ### Response: pilus involvement in attachment to collagen.


Instruction: How did this approach demonstrate pilus involvement in attachment to collagen by Streptococcus gallolyticus?

Output: adhesive matrix molecules

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did this approach demonstrate pilus involvement in attachment to collagen by Streptococcus gallolyticus?. ### Response: adhesive matrix molecules.


Instruction: How was a virulence factor demonstrated in an animal model of endocarditis?

Output: vaccine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was a virulence factor demonstrated in an animal model of endocarditis?. ### Response: vaccine.


Instruction: What did strains that expressed pil1 not adhere to either fibronectin or fibrinogen but did form biofilm in vitro?

Output: Lactococcus lactis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did strains that expressed pil1 not adhere to either fibronectin or fibrinogen but did form biofilm in vitro?. ### Response: Lactococcus lactis.


Instruction: A nonpathological Lactococcus lactis strain that by recombinant techniques expressed Pil1 in vivo was examined with what?

Output: biofilm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A nonpathological Lactococcus lactis strain that by recombinant techniques expressed Pil1 in vivo was examined with what?. ### Response: biofilm.


Instruction: What was examined with its parent strain that did not express Pil1 in a rat model of experimental endocarditis?

Output: Lactococcus lactis strain

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was examined with its parent strain that did not express Pil1 in a rat model of experimental endocarditis?. ### Response: Lactococcus lactis strain.


Instruction: The results suggested that Pil1 was important in vivo as what?

Output: virulence factor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The results suggested that Pil1 was important in vivo as what?. ### Response: virulence factor.


Instruction: What percentage of animals received the Pil1+ strain developed experimental endocarditis?

Output: 36%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of animals received the Pil1+ strain developed experimental endocarditis?. ### Response: 36%,.


Instruction: What are the three big 3 pathogens that account for the large majority of endotic cases?

Output: viridans group streptococci [VGS], S aureus, and Enterococcus species

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the three big 3 pathogens that account for the large majority of endotic cases?. ### Response: viridans group streptococci [VGS], S aureus, and Enterococcus species.


Instruction: Adhesins of S. cerevisiae are the primary focus of what?

Output: pathogenesis investigations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Adhesins of S. cerevisiae are the primary focus of what?. ### Response: pathogenesis investigations.


Instruction: What have MSCRAMMs been referred to as?

Output: microbial surface com-ponents recognizing adhesive matrix molecules

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have MSCRAMMs been referred to as?. ### Response: microbial surface com-ponents recognizing adhesive matrix molecules.


Instruction: Adhesins of S aureus are surface molecules involved in staphylococcal attachment to collagen, thrombospondin, laminin, fibrinogen, and fibronectin?

Output: 32

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Adhesins of S aureus are surface molecules involved in staphylococcal attachment to collagen, thrombospondin, laminin, fibrinogen, and fibronectin?. ### Response: 32.


Instruction: What may be important in the initial adherence of bacteria to a site of endothelial damage?

Output: These interactions with host proteins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be important in the initial adherence of bacteria to a site of endothelial damage?. ### Response: These interactions with host proteins.


Instruction: What is the host cell?

Output: endothelial cells, platelets

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the host cell?. ### Response: endothelial cells, platelets.


Instruction: What have been identified in strains of VGS and Enterococcus species that appear criti-cal in endocarditis pathogenesis?

Output: bacterial surface structures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have been identified in strains of VGS and Enterococcus species that appear criti-cal in endocarditis pathogenesis?. ### Response: bacterial surface structures.


Instruction: What is pivotal as we consider potential advances in infection treatment and preven-tion?

Output: Study of pathogenic mechanisms in IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is pivotal as we consider potential advances in infection treatment and preven-tion?. ### Response: Study of pathogenic mechanisms in IE.


Instruction: What is a foundation for the development of novel clinical tools?

Output: pathogenic mechanisms in IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a foundation for the development of novel clinical tools?. ### Response: pathogenic mechanisms in IE.


Instruction: What resulted from the identification of a virulence factor?

Output: development of a vaccine that reduced the risk of endocarditis development in an animal model

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What resulted from the identification of a virulence factor?. ### Response: development of a vaccine that reduced the risk of endocarditis development in an animal model.


Instruction: Which vaccine reduced the risk of endocarditis development in an animal model?

Output: virulence factor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which vaccine reduced the risk of endocarditis development in an animal model?. ### Response: virulence factor.