Instruction: What does the recommendation state-ments follow?

Output: a short remark, Key information (Balance ofbeneﬁts and harms, Quality of evidence, Values and preferences,Resource use and costs, Considerations for implementation), and arationale

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the recommendation state-ments follow?. ### Response: a short remark, Key information (Balance ofbeneﬁts and harms, Quality of evidence, Values and preferences,Resource use and costs, Considerations for implementation), and arationale.


Instruction: How is each recommendation linked to relevant SoF tables?

Output: Anunderlying rationale supported each practice point

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is each recommendation linked to relevant SoF tables?. ### Response: Anunderlying rationale supported each practice point.


Instruction: What was the primary source of evi-dence in the evidence review?

Output: RCTs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary source of evi-dence in the evidence review?. ### Response: RCTs.


Instruction: What did theERT do for a select number of clinical questions in this guideline?

Output: undertook a comprehensive evidence review beyond RCTs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did theERT do for a select number of clinical questions in this guideline?. ### Response: undertook a comprehensive evidence review beyond RCTs.


Instruction: What was not searched for in these reviews?

Output: specialty or regionaldatabases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not searched for in these reviews?. ### Response: specialty or regionaldatabases.


Instruction: Why was there no scoping exercise in the development of theseguidelines?

Output: no formal systematic evidencereview was undertaken

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was there no scoping exercise in the development of theseguidelines?. ### Response: no formal systematic evidencereview was undertaken.


Instruction: What type of exercise was not used in the development of these guidelines?

Output: scoping

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of exercise was not used in the development of these guidelines?. ### Response: scoping.


Instruction: What did no scoping exercise with patients do?

Output: searches of the quali-tative literature

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did no scoping exercise with patients do?. ### Response: searches of the quali-tative literature.


Instruction: Where did no formal qualitative evidence synthesis examine?

Output: patient priorities and preferences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where did no formal qualitative evidence synthesis examine?. ### Response: patient priorities and preferences.


Instruction: Powers et al 2019 Guidelines for Management of AIS e3713.6. Other IV Fibrinolytics and Sonothrombolysis COR LOE New, Revised, or Unchanged What is tenecteplase?

Output: single IV bolus of 0.25-mg/kg, maximum 25 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Powers et al 2019 Guidelines for Management of AIS e3713.6. Other IV Fibrinolytics and Sonothrombolysis COR LOE New, Revised, or Unchanged What is tenecteplase?. ### Response: single IV bolus of 0.25-mg/kg, maximum 25 mg.


Instruction: What is the maximum dose of IV tenecteplase?

Output: 0.4-mg/kg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the maximum dose of IV tenecteplase?. ### Response: 0.4-mg/kg.


Instruction: What was the usual dose of 0.9 mg/kg over 60 minutes in the EXTEND-IA?

Output: IV alteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the usual dose of 0.9 mg/kg over 60 minutes in the EXTEND-IA?. ### Response: IV alteplase.


Instruction: How many patients were randomized in the EXTEND-IA TNK trial?

Output: 202

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were randomized in the EXTEND-IA TNK trial?. ### Response: 202.


Instruction: What is the maximum dose of Tenecteplase before endovascular therapy for Ischemic Stroke?

Output: 90 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the maximum dose of Tenecteplase before endovascular therapy for Ischemic Stroke?. ### Response: 90 mg.


Instruction: What is proximal MCA?

Output: M1 or M2 segments

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is proximal MCA?. ### Response: M1 or M2 segments.


Instruction: How long after symptom onset do basilar arteries present to receive 1 fibrinolytic agent?

Output: 4.5 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after symptom onset do basilar arteries present to receive 1 fibrinolytic agent?. ### Response: 4.5 hours.


Instruction: What is the primary end point of reperfusion?

Output: >50% of the involved ischemic territory

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary end point of reperfusion?. ### Response: >50% of the involved ischemic territory.


Instruction: What was the primary end point achieved by 22% of patients treated with NIHSS?

Output: tenecteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary end point achieved by 22% of patients treated with NIHSS?. ### Response: tenecteplase.


Instruction: What did the trial test for noninferiority and, if nonproven, for superiority?

Output: P=0.002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the trial test for noninferiority and, if nonproven, for superiority?. ### Response: P=0.002.


Instruction: How long did the mRS score last?

Output: 90 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the mRS score last?. ### Response: 90 days.


Instruction: What percentage of patients treated with tenecteplase achieved the end point?

Output: 22%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients treated with tenecteplase achieved the end point?. ### Response: 22%.


Instruction: How many patients were treated with alteplasse?

Output: 10%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with alteplasse?. ### Response: 10%.


Instruction: What was the P value for noninferiority and superiority?

Output: 0.002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the P value for noninferiority and superiority?. ### Response: 0.002.


Instruction: In an analysis of secondary end points, what resulted in better functional outcomes at 90 days?

Output: tenecteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In an analysis of secondary end points, what resulted in better functional outcomes at 90 days?. ### Response: tenecteplase.


Instruction: What was the sICH rate in both studies?

Output: 1%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the sICH rate in both studies?. ### Response: 1%.


Instruction: How long did it take to obtain an mRS score of 0 to 1?

Output: P=0.23

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take to obtain an mRS score of 0 to 1?. ### Response: P=0.23.


Instruction: What was the sICH rate in both groups?

Output: 1%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the sICH rate in both groups?. ### Response: 1%.


Instruction: What is a possible alternative to alteplase?

Output: Tenecteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a possible alternative to alteplase?. ### Response: Tenecteplase.


Instruction: What can be considered as an alternative to alteplase in patients with minor neurological impairment?

Output: Tenecteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be considered as an alternative to alteplase in patients with minor neurological impairment?. ### Response: Tenecteplase.


Instruction: How long after stroke has IV tenectase been compared with IV alteplases?

Output: up to 6 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after stroke has IV tenectase been compared with IV alteplases?. ### Response: up to 6 hours.


Instruction: In 3 phase II and 1 phase III superiority trials, what appears to be similar?

Output: tenecteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In 3 phase II and 1 phase III superiority trials, what appears to be similar?. ### Response: tenecteplase.


Instruction: What appears to be similar to tenecteplase but is unclear whether it is as effective as or more effective than alteplas?

Output: safe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What appears to be similar to tenecteplase but is unclear whether it is as effective as or more effective than alteplas?. ### Response: safe.


Instruction: How many subjects were in the largest trial?

Output: 202

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many subjects were in the largest trial?. ### Response: 202.


Instruction: What dose did the biggest trial fail to demonstrate superiority?

Output: 0.4 mg/kg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What dose did the biggest trial fail to demonstrate superiority?. ### Response: 0.4 mg/kg.


Instruction: What is given as a single IV bolus as opposed to the 1-hour infusion?

Output: Tenecteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is given as a single IV bolus as opposed to the 1-hour infusion?. ### Response: Tenecteplase.


Instruction: What is the median NIHSS score?

Output: 17

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the median NIHSS score?. ### Response: 17.


Instruction: What is the difference between a single IV bolus and a 1-hour infusion of alteplase?

Output: Tenecteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between a single IV bolus and a 1-hour infusion of alteplase?. ### Response: Tenecteplase.


Instruction: What is a summary of the evidence quality in support of there recommendations?

Output: Table 3 ).

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a summary of the evidence quality in support of there recommendations?. ### Response: Table 3 )..


Instruction: What is the strength of a recommendation graded as?

Output: strong or weak

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the strength of a recommendation graded as?. ### Response: strong or weak.


Instruction: The balance of bene fits andharms across all critical and important outcomes determines what?

Output: The strengthof a recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The balance of bene fits andharms across all critical and important outcomes determines what?. ### Response: The strengthof a recommendation.


Instruction: What was the anticipated net health bene fit determined on the basis of?

Output: expected bene ﬁts and harms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the anticipated net health bene fit determined on the basis of?. ### Response: expected bene ﬁts and harms.


Instruction: What did the Work Group and ERT determine?

Output: the anticipated net health bene ﬁt

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Work Group and ERT determine?. ### Response: the anticipated net health bene ﬁt.


Instruction: How did the ERT assist Work Group members in evaluating the balance of bene fits and harms arising from key individualstudies?

Output: evi-dence review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did the ERT assist Work Group members in evaluating the balance of bene fits and harms arising from key individualstudies?. ### Response: evi-dence review.


Instruction: What was the overall quality of the evidence based on?

Output: the certainty of the evidence for all critical andimportant outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the overall quality of the evidence based on?. ### Response: the certainty of the evidence for all critical andimportant outcomes.


Instruction: What was graded A, B, C or D?

Output: overall quality of theevidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was graded A, B, C or D?. ### Response: overall quality of theevidence.


Instruction: What was the overall quality of the evidence graded?

Output: A, B, C, or D

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the overall quality of the evidence graded?. ### Response: A, B, C, or D.


Instruction: What is the GRADE system for grading quality of evidence?

Output: Grading of Recommendations Assessment, Development and Evaluation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the GRADE system for grading quality of evidence?. ### Response: Grading of Recommendations Assessment, Development and Evaluation.


Instruction: What would reduce the demonstrated effect?

Output: All plausible confounding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would reduce the demonstrated effect?. ### Response: All plausible confounding.


Instruction: What would be reduced by plausible confounding?

Output: the demonstrated effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would be reduced by plausible confounding?. ### Response: the demonstrated effect.


Instruction: What does GRADE stand for?

Output: Grading of Recommendations Assessment, Development and Evaluation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does GRADE stand for?. ### Response: Grading of Recommendations Assessment, Development and Evaluation.


Instruction: What is the name of the randomized controlled trial?

Output: RCT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized controlled trial?. ### Response: RCT.


Instruction: What percentage of people in your situation would want the recommended course ofaction?

Output: The majority

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of people in your situation would want the recommended course ofaction?. ### Response: The majority.


Instruction: What should most patients receive?

Output: therecommended course of action

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should most patients receive?. ### Response: therecommended course of action.


Instruction: The recommendation can be evaluated as a candidate for what?

Output: developing a policy or aperformance measure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The recommendation can be evaluated as a candidate for what?. ### Response: developing a policy or aperformance measure.


Instruction: How many people in your situation would want the recommended courseof action?

Output: The majority

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people in your situation would want the recommended courseof action?. ### Response: The majority.


Instruction: What will be appropriate fordifferent patients?

Output: Different choices

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will be appropriate fordifferent patients?. ### Response: Different choices.


Instruction: Each patient needshelp to arrive at a management decision consistent with what?

Output: her or his values andpreferences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Each patient needshelp to arrive at a management decision consistent with what?. ### Response: her or his values andpreferences.


Instruction: The recommendation is likely to require what before policy can be determined?

Output: ubstantial debate and involvement ofstakeholders

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The recommendation is likely to require what before policy can be determined?. ### Response: ubstantial debate and involvement ofstakeholders.


Instruction: What is required before policy can be determined?

Output: ubstantial debate and involvement ofstakeholders

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is required before policy can be determined?. ### Response: ubstantial debate and involvement ofstakeholders.


Instruction: What is the most likely a strong recommendation?

Output: weak

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most likely a strong recommendation?. ### Response: weak.


Instruction: What is a J-shaped relationship between alcohol consumption and ischemic stroke?

Output: regardless of sex

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a J-shaped relationship between alcohol consumption and ischemic stroke?. ### Response: regardless of sex.


Instruction: What is the risk associated with heavy alcohol consumption?

Output: Stroke risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk associated with heavy alcohol consumption?. ### Response: Stroke risk.


Instruction: How many drinks in a day or more is considered to be a risk factor for ischemia?

Output: >4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many drinks in a day or more is considered to be a risk factor for ischemia?. ### Response: >4.


Instruction: How many drinks in a day does a man drink?

Output: >4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many drinks in a day does a man drink?. ### Response: >4.


Instruction: What is the risk of harmful alcohol consumption in recurrent stroke?

Output: The risk of harmful alcohol consumption in recurrent stroke is not well defined

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of harmful alcohol consumption in recurrent stroke?. ### Response: The risk of harmful alcohol consumption in recurrent stroke is not well defined.


Instruction: How much alcohol is consumed per day in men?

Output: >4 drinks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much alcohol is consumed per day in men?. ### Response: >4 drinks.


Instruction: In women, how many drinks are consumed per week?

Output: >7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In women, how many drinks are consumed per week?. ### Response: >7.


Instruction: What has been asso-ciated with stroke recurrence at 90 days?

Output: High alcohol intake

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been asso-ciated with stroke recurrence at 90 days?. ### Response: High alcohol intake.


Instruction: What is the RR for ischemic stroke at that consumption level?

Output: 1.69

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the RR for ischemic stroke at that consumption level?. ### Response: 1.69.


Instruction: The World Drug Report (2017) relates a 23% increase in the number of estimated drug users?

Output: 166

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The World Drug Report (2017) relates a 23% increase in the number of estimated drug users?. ### Response: 166.


Instruction: How much has the number of drug users increased in 11 years?

Output: 23%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much has the number of drug users increased in 11 years?. ### Response: 23%.


Instruction: How many estimated drug users were there in 2015?

Output: 255 million

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many estimated drug users were there in 2015?. ### Response: 255 million.


Instruction: What was noted to coincide with the emergent opioid epidemic?

Output: A sharp increase in US stroke rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was noted to coincide with the emergent opioid epidemic?. ### Response: A sharp increase in US stroke rates.


Instruction: What is the association between drug use and ischemic stroke?

Output: Evidence sup-porting an association between drug use and ischemic stroke, notably in stimulants and developing in canna-bis use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association between drug use and ischemic stroke?. ### Response: Evidence sup-porting an association between drug use and ischemic stroke, notably in stimulants and developing in canna-bis use.


Instruction: What must be addressed in stroke prevention strategies?

Output: Evidence sup-porting an association between drug use and ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must be addressed in stroke prevention strategies?. ### Response: Evidence sup-porting an association between drug use and ischemic stroke.


Instruction: The STOP trial can show what?

Output: decreased alcohol consumption levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The STOP trial can show what?. ### Response: decreased alcohol consumption levels.


Instruction: What has been identified as an independent risk factor for stroke recurrence at 90 days in minor stroke/TIA?

Output: High alcohol intake

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been identified as an independent risk factor for stroke recurrence at 90 days in minor stroke/TIA?. ### Response: High alcohol intake.


Instruction: Low to moderate alcohol con-sumption is protective in what type of stroke?

Output: ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Low to moderate alcohol con-sumption is protective in what type of stroke?. ### Response: ischemic stroke.


Instruction: What is the protective effect of moderate alcohol consumption?

Output: lowest risk for mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the protective effect of moderate alcohol consumption?. ### Response: lowest risk for mortality.


Instruction: What is increased risk at higher exposure levels?

Output: mic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is increased risk at higher exposure levels?. ### Response: mic stroke.


Instruction: The EPIC-CVD observa-tional case-cohort study identified an ischemic stroke HR of 1.04 per 12 g/d increase in what?

Output: alcohol consumption

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The EPIC-CVD observa-tional case-cohort study identified an ischemic stroke HR of 1.04 per 12 g/d increase in what?. ### Response: alcohol consumption.


Instruction: What is the HR for ischemic stroke?

Output: 1.04

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the HR for ischemic stroke?. ### Response: 1.04.


Instruction: What are the HRs for alcohol consumption?

Output: 15.0 to 29.9, 30.0 to 59.9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the HRs for alcohol consumption?. ### Response: 15.0 to 29.9, 30.0 to 59.9.


Instruction: How many g/d total alcohol consumed?

Output: ≥ 60

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many g/d total alcohol consumed?. ### Response: ≥ 60.


Instruction: How much alcohol does a person drink a day?

Output: >4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much alcohol does a person drink a day?. ### Response: >4.


Instruction: What is the lowest risk for mortality in both men and women?

Output: alcohol con-sumption of <12 g/d

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the lowest risk for mortality in both men and women?. ### Response: alcohol con-sumption of <12 g/d.


Instruction: No data confirm drug use and what else?

Output: recurrent stroke risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No data confirm drug use and what else?. ### Response: recurrent stroke risk.


Instruction: No data confirm drug use and recurrent stroke risk.

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No data confirm drug use and recurrent stroke risk.. ### Response: 2.


Instruction: Current users of what type of stimu-lants have a higher ischemic stroke risk?

Output: amphetamine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Current users of what type of stimu-lants have a higher ischemic stroke risk?. ### Response: amphetamine.


Instruction: What is the adjusted RR (methylphenidate) for TIA?

Output: 1.6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the adjusted RR (methylphenidate) for TIA?. ### Response: 1.6.


Instruction: What type of cocaine was found to have an increased risk of stroke?

Output: powder/paste cocaine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of cocaine was found to have an increased risk of stroke?. ### Response: powder/paste cocaine.


Instruction: What was the adjusted OR of powder/paste cocaine?

Output: 13.9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the adjusted OR of powder/paste cocaine?. ### Response: 13.9.


Instruction: How much was crack cocaine's adjusted OR?

Output: 11.2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much was crack cocaine's adjusted OR?. ### Response: 11.2.


Instruction: What is the weight of evidence ranked as using specificdefinitions that are included in Table 1?

Output: LOE A, B, or C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the weight of evidence ranked as using specificdefinitions that are included in Table 1?. ### Response: LOE A, B, or C.


Instruction: What are studies identified asobservational, retrospective, prospective, or randomized where appropriate?

Output: weight of evidence ranked as LOE A, B, or C using specificdefinitions that are included in Table 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are studies identified asobservational, retrospective, prospective, or randomized where appropriate?. ### Response: weight of evidence ranked as LOE A, B, or C using specificdefinitions that are included in Table 1.


Instruction: For conditions for which inadequate data are available, recommendations are based on expert consensus and what?

Output: clinical experience

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For conditions for which inadequate data are available, recommendations are based on expert consensus and what?. ### Response: clinical experience.


Instruction: What is ranked as LOE C?

Output: recommendations are based on expert consensus andclinical experience

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ranked as LOE C?. ### Response: recommendations are based on expert consensus andclinical experience.


Instruction: What is supported by historical clinical data?

Output: recommenda-tions at LOE C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is supported by historical clinical data?. ### Response: recommenda-tions at LOE C.


Instruction: A surveyof current practice among the clinicians on the writing group is what?

Output: the basis for LOE C recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A surveyof current practice among the clinicians on the writing group is what?. ### Response: the basis for LOE C recommendations.


Instruction: Who is the basis for LOE C recommendations?

Output: a surveyof current practice among the clinicians on the writing group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the basis for LOE C recommendations?. ### Response: a surveyof current practice among the clinicians on the writing group.


Instruction: What is the schema for COR and LOE summarized in?

Output: Table 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the schema for COR and LOE summarized in?. ### Response: Table 1.


Instruction: What is the purpose of Class III recommendations?

Output: to delineatewhether the recommendation is determined to be of “nobenefit” or is associated with “harm” to the patient

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of Class III recommendations?. ### Response: to delineatewhether the recommendation is determined to be of “nobenefit” or is associated with “harm” to the patient.


Instruction: What does this methodology delineate?

Output: optimal medical therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does this methodology delineate?. ### Response: optimal medical therapy.


Instruction: What is the term for guideline-directed medical therapy?

Output: GDMT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for guideline-directed medical therapy?. ### Response: GDMT.


Instruction: What is GDMT?

Output: guideline-directed medical therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is GDMT?. ### Response: guideline-directed medical therapy.


Instruction: What is the new term for guideline-directed medical therapy?

Output: GDMT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the new term for guideline-directed medical therapy?. ### Response: GDMT.


Instruction: What are the ACCF/AHA practice guidelines aimed at?

Output: pa-tient populations (and healthcare providers) residing in NorthAmerica

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the ACCF/AHA practice guidelines aimed at?. ### Response: pa-tient populations (and healthcare providers) residing in NorthAmerica.


Instruction: Where are drugs that are not currently available in North America discussed without a specific COR?

Output: ACCF/AHA practice guidelines address pa-tient populations (and healthcare providers) residing in NorthAmerica, drugs that are not currently available in NorthAmerica are discussed in the text

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are drugs that are not currently available in North America discussed without a specific COR?. ### Response: ACCF/AHA practice guidelines address pa-tient populations (and healthcare providers) residing in NorthAmerica, drugs that are not currently available in NorthAmerica are discussed in the text.


Instruction: For studies performed in large numbers of subjects outside of North America, each writing group reviews the potential impact of what?

Output: different practice patterns and patient populations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For studies performed in large numbers of subjects outside of North America, each writing group reviews the potential impact of what?. ### Response: different practice patterns and patient populations.


Instruction: What are the ACCF/AHA practice guidelines intended to assist with?

Output: pa-tient populations (and healthcare providers) residing in NorthAmerica

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the ACCF/AHA practice guidelines intended to assist with?. ### Response: pa-tient populations (and healthcare providers) residing in NorthAmerica.


Instruction: What type of care is targeted by absolute risk?

Output: primary care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of care is targeted by absolute risk?. ### Response: primary care.


Instruction: What year did NZ Med J. 118:U1676.

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did NZ Med J. 118:U1676.. ### Response: 2005.


Instruction: How long did it take to target absolute risk of coronary heart disease in type 2 diabetes patients?

Output: 10-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take to target absolute risk of coronary heart disease in type 2 diabetes patients?. ### Response: 10-year.


Instruction: What is a gap in cardiovascular dis-ease risk management in Australian general practice?

Output: Webster RJ, Heeley EL, Peiris DP, et al. Gaps

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a gap in cardiovascular dis-ease risk management in Australian general practice?. ### Response: Webster RJ, Heeley EL, Peiris DP, et al. Gaps.


Instruction: Med J Aust. 2009;191:324-9.

Output: S8.1.2-44

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Med J Aust. 2009;191:324-9.. ### Response: S8.1.2-44.


Instruction: What does the new PRIM score predict?

Output: coronary heart disease risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the new PRIM score predict?. ### Response: coronary heart disease risk.


Instruction: What is the name of the journal that published the study?

Output: ahajournals.org

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that published the study?. ### Response: ahajournals.org.


Instruction: When was the study released?

Output: May 3, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the study released?. ### Response: May 3, 2023.


Instruction: How many plasma samples were taken from unfractionated heparin-treated patients in 2000?

Output: 2,773

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many plasma samples were taken from unfractionated heparin-treated patients in 2000?. ### Response: 2,773.


Instruction: How many plasma samples were taken from unfractionated heparin-treated patients in 1997?

Output: 2,773

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many plasma samples were taken from unfractionated heparin-treated patients in 1997?. ### Response: 2,773.


Instruction: What is an institution-specifi c therapeutic range for heparin?

Output: adjusted-dose unfractionated

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an institution-specifi c therapeutic range for heparin?. ### Response: adjusted-dose unfractionated.


Instruction: What year was the Am J Health Syst Pharm published?

Output: 1998

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the Am J Health Syst Pharm published?. ### Response: 1998.


Instruction: How many ( 19 ): 2002 - 2006?

Output: 55

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many ( 19 ): 2002 - 2006?. ### Response: 55.


Instruction: What was the total number of drugs used from 1998 to 2006 in the United States?

Output: 82

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the total number of drugs used from 1998 to 2006 in the United States?. ### Response: 82.


Instruction: Anticoagulants and thrombolytics are two examples of what type of drugs?

Output: Toxic effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Anticoagulants and thrombolytics are two examples of what type of drugs?. ### Response: Toxic effects.


Instruction: What is a risk and benefi ts of drugs used in the ICU?

Output: Toxic effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk and benefi ts of drugs used in the ICU?. ### Response: Toxic effects.


Instruction: Crit Care Clin. 1991; 7 ( 3 ): 533 - 554: what?

Output: heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Crit Care Clin. 1991; 7 ( 3 ): 533 - 554: what?. ### Response: heparin.


Instruction: What is the name of the heparin assays based on ex-vivo samples?

Output: Thromb Haemost

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the heparin assays based on ex-vivo samples?. ### Response: Thromb Haemost.


Instruction: What was the time of the activated partial thromboplastin?

Output: 1991 ; 7 ( 3 ): 533 - 554

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the time of the activated partial thromboplastin?. ### Response: 1991 ; 7 ( 3 ): 533 - 554.


Instruction: What are heparin assays based on?

Output: ex-vivo heparin samples

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are heparin assays based on?. ### Response: ex-vivo heparin samples.


Instruction: How many ( 1 ): 16-23?

Output: 63

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many ( 1 ): 16-23?. ### Response: 63.


Instruction: What did the Quality Management Program of Ontario coagula-tion surveys learn from?

Output: Interlaboratory variation in heparin monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Quality Management Program of Ontario coagula-tion surveys learn from?. ### Response: Interlaboratory variation in heparin monitoring.


Instruction: What was the number of Thromb Haemost cases in 2010?

Output: 837 - 844

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the number of Thromb Haemost cases in 2010?. ### Response: 837 - 844.


Instruction: How many Thromb Haemost cases were there in 2010?

Output: 837 - 844

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many Thromb Haemost cases were there in 2010?. ### Response: 837 - 844.


Instruction: What was the total number of cases of thrombus haemost?

Output: 16 - 23

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the total number of cases of thrombus haemost?. ### Response: 16 - 23.


Instruction: What is a standard heparin nomogram for the management of hep-arin therapy?

Output: Arch Intern Med

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a standard heparin nomogram for the management of hep-arin therapy?. ### Response: Arch Intern Med.


Instruction: What is the 151 ( 2 ): 333 - 337?

Output: A standard heparin nomogram

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 151 ( 2 ): 333 - 337?. ### Response: A standard heparin nomogram.


Instruction: What is the difference between subcutaneous adjusted-dose unfractionated heparin vs fixed-dose low-molecular-weight Heparin in the initial treatment of venous vein?

Output: ﬁ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between subcutaneous adjusted-dose unfractionated heparin vs fixed-dose low-molecular-weight Heparin in the initial treatment of venous vein?. ### Response: ﬁ.


Instruction: What does xed-dose low-molecular-weight heparin do?

Output: initial treatment of venous thromboembolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does xed-dose low-molecular-weight heparin do?. ### Response: initial treatment of venous thromboembolism.


Instruction: What is used in the initial treatment of venous thromboembolism?

Output: Subcutaneous adjusted-dose unfractionated heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used in the initial treatment of venous thromboembolism?. ### Response: Subcutaneous adjusted-dose unfractionated heparin.


Instruction: How many ( 10 ): 1077-1083?

Output: 164

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many ( 10 ): 1077-1083?. ### Response: 164.


Instruction: What are the ACC/AHA Guidelines for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction?

Output: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the ACC/AHA Guidelines for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction?. ### Response: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.


Instruction: What is a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines?

Output: 1999 update:  ACC/AHA guidelines for the management of patients with acute myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines?. ### Response: 1999 update:  ACC/AHA guidelines for the management of patients with acute myocardial infarction.


Instruction: What is the name of the Task Force on Practice Guidelines?

Output: American College of Cardiology/American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Practice Guidelines?. ### Response: American College of Cardiology/American Heart Association.


Instruction: When was the J Am Coll Cardiol 36 (3): 970-1062?

Output: 2000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol 36 (3): 970-1062?. ### Response: 2000.


Instruction: What are the ACC/AHA guidelines for the management of patients with acute myocardial infarction?

Output: unstable angina and non-ST-segment elevation myocardial infarction .  A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the ACC/AHA guidelines for the management of patients with acute myocardial infarction?. ### Response: unstable angina and non-ST-segment elevation myocardial infarction .  A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.


Instruction: Task Force on Practice Guidelines. 1999 ; 34 (3): 890 - 911.

Output: J Am Coll Cardiol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Task Force on Practice Guidelines. 1999 ; 34 (3): 890 - 911.. ### Response: J Am Coll Cardiol.


Instruction: Who wrote Heparin: Chemical and Biological Properties, Clinical Applications?

Output: Land DA, Lindahl U, eds.  Heparin: Chemical and Biological Properties, Clinical Applications  .  London, England :  Edward Arnold

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote Heparin: Chemical and Biological Properties, Clinical Applications?. ### Response: Land DA, Lindahl U, eds.  Heparin: Chemical and Biological Properties, Clinical Applications  .  London, England :  Edward Arnold.


Instruction: Where did Land DA and Lindahl U live?

Output: London, England

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where did Land DA and Lindahl U live?. ### Response: London, England.


Instruction: What is Morabia A referring to?

Output: Heparin doses and major bleedings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Morabia A referring to?. ### Response: Heparin doses and major bleedings.


Instruction: What is the name of the journal that published a study on Heparin doses and bleedings?

Output: Lancet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that published a study on Heparin doses and bleedings?. ### Response: Lancet.


Instruction: 57. Antman EM. the TIMI 9A Investigators?

Output: Hirudin in acute

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: 57. Antman EM. the TIMI 9A Investigators?. ### Response: Hirudin in acute.


Instruction: Hirudin in acute acute pain?

Output: heparin vs ﬁ  xed-dose low-molecular-weight heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hirudin in acute acute pain?. ### Response: heparin vs ﬁ  xed-dose low-molecular-weight heparin.


Instruction: What did Page and al 2015 ACC/AHA/HRS SVT Guideline e5458.2. Ongoing Management: Recommendations9. Special Populations9.1. What does the present docu-ment offer no specific recommendations for?

Output: pediatric patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Page and al 2015 ACC/AHA/HRS SVT Guideline e5458.2. Ongoing Management: Recommendations9. Special Populations9.1. What does the present docu-ment offer no specific recommendations for?. ### Response: pediatric patients.


Instruction: What does SVT in young patients differ from in terms of mechanism, risk of developing heart failure or cardiac arrest?

Output: significantly from SVT in adult patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does SVT in young patients differ from in terms of mechanism, risk of developing heart failure or cardiac arrest?. ### Response: significantly from SVT in adult patients.


Instruction: What is a brief discussion of SVT for pediatric patients?

Output: a brief discussion of SVT in pediatric patients is included below

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a brief discussion of SVT for pediatric patients?. ### Response: a brief discussion of SVT in pediatric patients is included below.


Instruction: What is the risk of developing heart failure or cardiac arrest?

Output: risks associated with inter -ventional therapy, natural history, and psychosocial impact

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of developing heart failure or cardiac arrest?. ### Response: risks associated with inter -ventional therapy, natural history, and psychosocial impact.


Instruction: What is half of pediatric SVT presented in the first 4 months of life?

Output: Approximately half of pediatric SVT presents in the first 4 months of life, with age-related peaks in occurrence subse-quently at 5 to 8 years and after 13 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is half of pediatric SVT presented in the first 4 months of life?. ### Response: Approximately half of pediatric SVT presents in the first 4 months of life, with age-related peaks in occurrence subse-quently at 5 to 8 years and after 13 years.


Instruction: When do age related peaks in occurrence occur?

Output: 5 to 8 years and after 13 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When do age related peaks in occurrence occur?. ### Response: 5 to 8 years and after 13 years.


Instruction: How much of SVT does accessory pathway-mediated tachycardia account for in infants?

Output: >70%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of SVT does accessory pathway-mediated tachycardia account for in infants?. ### Response: >70%.


Instruction: How much does A VNRT increase with age?

Output: 9% to 13%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much does A VNRT increase with age?. ### Response: 9% to 13%.


Instruction: What percentage of SVT is in teenagers?

Output: 55%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of SVT is in teenagers?. ### Response: 55%.


Instruction: After what age are women more likely to have A VNRT than men?

Output: 12 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: After what age are women more likely to have A VNRT than men?. ### Response: 12 years of age.


Instruction: What is less frequent among African American and Hispanic patients than in the general pediatric population?

Output: SVT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is less frequent among African American and Hispanic patients than in the general pediatric population?. ### Response: SVT.


Instruction: Atrial flutter is seen in some neonates and in older patients.

Output: 56 Atrial flutter is seen in some neonates and in older children is predominantly observed after congenital heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atrial flutter is seen in some neonates and in older patients.. ### Response: 56 Atrial flutter is seen in some neonates and in older children is predominantly observed after congenital heart disease.


Instruction: Atrial flutter is seen in some neonates and in older children after what type of heart disease?

Output: congenital

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atrial flutter is seen in some neonates and in older children after what type of heart disease?. ### Response: congenital.


Instruction: AF is uncommon in childhood, accounting for what percentage of supraven-tricular arrhythmias?

Output: <3%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: AF is uncommon in childhood, accounting for what percentage of supraven-tricular arrhythmias?. ### Response: <3%.


Instruction: What type of heart disease is SVT associated with?

Output: heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of heart disease is SVT associated with?. ### Response: heart failure.


Instruction: What is present in up to 20% of infants and in older children?

Output: Congestive heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is present in up to 20% of infants and in older children?. ### Response: Congestive heart failure.


Instruction: What is present in 20% to 35% of children with SVT?

Output: Pre-excitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is present in 20% to 35% of children with SVT?. ### Response: Pre-excitation.


Instruction: What is the risk of ventricular fibrillation or SCD related to WPW in childhood?

Output: 1.3% to 1.6%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of ventricular fibrillation or SCD related to WPW in childhood?. ### Response: 1.3% to 1.6%.


Instruction: What is fibrillation related to WPW in childhood?

Output: SCD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is fibrillation related to WPW in childhood?. ### Response: SCD.


Instruction: What is the highest risk of cardiac arrest in patients with A VRT precipitating AF?

Output: heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the highest risk of cardiac arrest in patients with A VRT precipitating AF?. ### Response: heart failure.


Instruction: What is a risk stratification method for children with pre-excitation?

Output: ambulatory 24-hour monitoring or treadmill exercise testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk stratification method for children with pre-excitation?. ### Response: ambulatory 24-hour monitoring or treadmill exercise testing.


Instruction: What is an example of ambulatory 24-hour monitoring or treadmill exercise testing?

Output: Risk stratification

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of ambulatory 24-hour monitoring or treadmill exercise testing?. ### Response: Risk stratification.


Instruction: What can be used to assess persistence of pre-excitation in children?

Output: Risk stratification

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be used to assess persistence of pre-excitation in children?. ### Response: Risk stratification.


Instruction: What is largely based on practice patterns?

Output: Pharmacological therapy of SVT in childhood

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is largely based on practice patterns?. ### Response: Pharmacological therapy of SVT in childhood.


Instruction: Why are RCTs of antiarrhythmic medications in children lacking?

Output: practice patterns

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why are RCTs of antiarrhythmic medications in children lacking?. ### Response: practice patterns.


Instruction: What is the name of the community based study in Joinville, Brazil?

Output: Incidence of stroke subtypes, prognosis andprevalence of risk factors in Joinville, Brazil : a 2 year community basedstudy. J Neurol Neurosurg Psychiatry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the community based study in Joinville, Brazil?. ### Response: Incidence of stroke subtypes, prognosis andprevalence of risk factors in Joinville, Brazil : a 2 year community basedstudy. J Neurol Neurosurg Psychiatry.


Instruction: How long did the study last?

Output: 2 year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the study last?. ### Response: 2 year.


Instruction: What was the outcome of the study?

Output: double-blind

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome of the study?. ### Response: double-blind.


Instruction: What is the first post-operative week after intracranial surgery?

Output: Seizures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the first post-operative week after intracranial surgery?. ### Response: Seizures.


Instruction: What is Epilepsy after stroke?

Output: Epilepsia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Epilepsy after stroke?. ### Response: Epilepsia.


Instruction: What is the name of the disease that causes epilepsy after stroke?

Output: Epilepsia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease that causes epilepsy after stroke?. ### Response: Epilepsia.


Instruction: When was Epilepsia.33:495–498.284?

Output: 1992

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Epilepsia.33:495–498.284?. ### Response: 1992.


Instruction: What treatment was used to treat seizures after aneurysmal subarachnoid hemorrhage?

Output: coil embolization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What treatment was used to treat seizures after aneurysmal subarachnoid hemorrhage?. ### Response: coil embolization.


Instruction: What is nonconvulsive status epilepticus after subarachnoid hemorrhage?

Output: Seizures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is nonconvulsive status epilepticus after subarachnoid hemorrhage?. ### Response: Seizures.


Instruction: What is a double-blind study of phenytoinand postoperative epilepsy?

Output: J Neurosurg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a double-blind study of phenytoinand postoperative epilepsy?. ### Response: J Neurosurg.


Instruction: What is phenytoinand postoperative epilepsy: a double-blind study?

Output: J Neurosurg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is phenytoinand postoperative epilepsy: a double-blind study?. ### Response: J Neurosurg.


Instruction: What is the effect of anticonvulsanttherapy?

Output: efficacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of anticonvulsanttherapy?. ### Response: efficacy.


Instruction: Who is Epilepsy following neurosurgical intervention?

Output: O’Laoire SA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Epilepsy following neurosurgical intervention?. ### Response: O’Laoire SA.


Instruction: What is associated with functional and cognitive disability after subarachnoid hemorrhage?

Output: Phenytoinexposure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with functional and cognitive disability after subarachnoid hemorrhage?. ### Response: Phenytoinexposure.


Instruction: What is the effect of phenytoinexposure on cognitive disability?

Output: functional and cognitive disability aftersubarachnoid hemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of phenytoinexposure on cognitive disability?. ### Response: functional and cognitive disability aftersubarachnoid hemorrhage.


Instruction: What is cognitive disability aftersubarachnoid hemorrhage?

Output: Phenytoinexposure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is cognitive disability aftersubarachnoid hemorrhage?. ### Response: Phenytoinexposure.


Instruction: What is the name of the disease that causes cognitive disability?

Output: Phenytoinexposure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease that causes cognitive disability?. ### Response: Phenytoinexposure.


Instruction: What is the cause of subarachnoid hemorrhage from aneu-rysms?

Output: Increasedurinary sodium excretion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cause of subarachnoid hemorrhage from aneu-rysms?. ### Response: Increasedurinary sodium excretion.


Instruction: What does Roberts P. say about electrolyte changes in patients with arachnoea?

Output: Trends in blood pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Roberts P. say about electrolyte changes in patients with arachnoea?. ### Response: Trends in blood pressure.


Instruction: When did James IM publish a paper on electrolytes in patients?

Output: 1989

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did James IM publish a paper on electrolytes in patients?. ### Response: 1989.


Instruction: Hypo-natremia and cerebrovascular spasm in aneurysmal subarachnoid hem-orrhage. Neurol India. 2006;54:273–275.296.

Output: Increasedurinary sodium excretion in the early phase of aneurysmal subarachnoidhemorrhage as a predictor of cerebral salt wasting syndrome [inJapanese]. Brain Nerve . 2009;61:1419–1423.297

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hypo-natremia and cerebrovascular spasm in aneurysmal subarachnoid hem-orrhage. Neurol India. 2006;54:273–275.296.. ### Response: Increasedurinary sodium excretion in the early phase of aneurysmal subarachnoidhemorrhage as a predictor of cerebral salt wasting syndrome [inJapanese]. Brain Nerve . 2009;61:1419–1423.297.


Instruction: Nakagawa I, Kurokawa S, Takayama K, Wada T, Nakase H. Increasedurinary sodium excretion in the early phase of what?

Output: aneurysmal subarachnoidhemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Nakagawa I, Kurokawa S, Takayama K, Wada T, Nakase H. Increasedurinary sodium excretion in the early phase of what?. ### Response: aneurysmal subarachnoidhemorrhage.


Instruction: What is cerebral salt wasting syndrome?

Output: Increasedurinary sodium excretion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is cerebral salt wasting syndrome?. ### Response: Increasedurinary sodium excretion.


Instruction: What is Friedman WA?

Output: Hyponatremia in neurosurgical patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Friedman WA?. ### Response: Hyponatremia in neurosurgical patients.


Instruction: What did the Work Group decide upon?

Output: “Weak for” recommenda tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Work Group decide upon?. ### Response: “Weak for” recommenda tion.


Instruction: What is needed to identify the most effective, safe approach for lowering risk for CVD events?

Output: More research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed to identify the most effective, safe approach for lowering risk for CVD events?. ### Response: More research.


Instruction: Dosages and other interventions for secondary prevention should be evaluated?

Output: statin doses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Dosages and other interventions for secondary prevention should be evaluated?. ### Response: statin doses.


Instruction: What should be prospectively evaluated to identify patients at sufficiently high risk?

Output: Risk stratification

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be prospectively evaluated to identify patients at sufficiently high risk?. ### Response: Risk stratification.


Instruction: What is one of the side effects of statin?

Output: 67:2395–410

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the side effects of statin?. ### Response: 67:2395–410.


Instruction: What is the name of the journal that published the study on statin side effects?

Output: ahajournals.org

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that published the study on statin side effects?. ### Response: ahajournals.org.


Instruction: When was the study published?

Output: May 1, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the study published?. ### Response: May 1, 2023.


Instruction: What is the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al 2020 ACC/AHA Guideline for the Management of Valvular Heart DiseaseFebruary 2, 2021 Circulation. 2021;143:e72–e227

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al 2020 ACC/AHA Guideline for the Management of Valvular Heart DiseaseFebruary 2, 2021 Circulation. 2021;143:e72–e227.


Instruction: What is a recommendation for Timing of Intervention for Mixed AS and AR?

Output: AVR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a recommendation for Timing of Intervention for Mixed AS and AR?. ### Response: AVR.


Instruction: What does Online Data Supplement 33.COR LOE Recommendations1 B-NR1 summarize?

Output: studies that support the recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Online Data Supplement 33.COR LOE Recommendations1 B-NR1 summarize?. ### Response: studies that support the recommendations.


Instruction: In symptomatic patients with combined AS and AR, what is the peak transvalvular jet velocity of at least 4.0 m/s?

Output: AVR is recommended

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In symptomatic patients with combined AS and AR, what is the peak transvalvular jet velocity of at least 4.0 m/s?. ### Response: AVR is recommended.


Instruction: What is the mean transvalvular gradient of at least 40 mm Hg?

Output: AVR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the mean transvalvular gradient of at least 40 mm Hg?. ### Response: AVR.


Instruction: What is SAVR recommended for in asymptomatic patients with combined AS and AR?

Output: jet velocity of ≥4.0 m/s with an LVEF <50%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SAVR recommended for in asymptomatic patients with combined AS and AR?. ### Response: jet velocity of ≥4.0 m/s with an LVEF <50%,.


Instruction: What is the peak transvalvular jet velocity of 4.0 m/s?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the peak transvalvular jet velocity of 4.0 m/s?. ### Response: ≥.


Instruction: Isolated moderate AS or moderate AR is currently placed in what stage?

Output: Stage B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Isolated moderate AS or moderate AR is currently placed in what stage?. ### Response: Stage B.


Instruction: What is Stage B progressive disease for which no therapeutic action is indicated?

Output: isolated moderate AS or moderate AR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Stage B progressive disease for which no therapeutic action is indicated?. ### Response: isolated moderate AS or moderate AR.


Instruction: Some patients with moderate mixed disease develop symptoms that stem from their valve disease?

Output: LV dysfunction, as evidenced by an LVEF of <50%, and who have no other reason for LV dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Some patients with moderate mixed disease develop symptoms that stem from their valve disease?. ### Response: LV dysfunction, as evidenced by an LVEF of <50%, and who have no other reason for LV dysfunction.


Instruction: What argument was raised that if there was no AR, the aortic jet velocity and gradient would be what?

Output: correspondingly lower

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What argument was raised that if there was no AR, the aortic jet velocity and gradient would be what?. ### Response: correspondingly lower.


Instruction: What would not meet the definitions for severe AS?

Output: aortic jet velocity and gradient

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would not meet the definitions for severe AS?. ### Response: aortic jet velocity and gradient.


Instruction: What would be only moderate AR by defi-nition?

Output: aortic jet velocity and gradient would be correspondingly lower and would not meet the definitions for severe AS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would be only moderate AR by defi-nition?. ### Response: aortic jet velocity and gradient would be correspondingly lower and would not meet the definitions for severe AS.


Instruction: Recent data suggest that the natural his-tory of moderate mixed disease behaves similarly to that of pure disease?

Output: valve disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Recent data suggest that the natural his-tory of moderate mixed disease behaves similarly to that of pure disease?. ### Response: valve disease.


Instruction: How does moderate mixed disease compare to pure severe AS1?

Output: similarly

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does moderate mixed disease compare to pure severe AS1?. ### Response: similarly.


Instruction: What is a similar mortality risk to that of pure severe ass?

Output: moderate mixed disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a similar mortality risk to that of pure severe ass?. ### Response: moderate mixed disease.


Instruction: How is valve replacement war -ranted for the symptomatic patient if the patient's data meet criteria for severe AS?

Output: AVR is recommended

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is valve replacement war -ranted for the symptomatic patient if the patient's data meet criteria for severe AS?. ### Response: AVR is recommended.


Instruction: What criteria does TAVI ver -sus SAVR meet for severe AS?

Output: any of the criteria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What criteria does TAVI ver -sus SAVR meet for severe AS?. ### Response: any of the criteria.


Instruction: What is discussed in Section 3.2.4.2.2?

Output: The decision about whether to proceed with TAVI ver -sus SAVR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is discussed in Section 3.2.4.2.2?. ### Response: The decision about whether to proceed with TAVI ver -sus SAVR.


Instruction: What is presumed to be the cause of LV dysfunction?

Output: valve disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is presumed to be the cause of LV dysfunction?. ### Response: valve disease.


Instruction: What is indicated in mixed AS and MRPatients with combined AS and MR?

Output: AVR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is indicated in mixed AS and MRPatients with combined AS and MR?. ### Response: AVR.


Instruction: What kind of decision-making process is involved in an in-dividual patient?

Output: shared decision-making with the patient

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What kind of decision-making process is involved in an in-dividual patient?. ### Response: shared decision-making with the patient.


Instruction: What type of AS and primary MR patients are best treated with?

Output: combined

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of AS and primary MR patients are best treated with?. ### Response: combined.


Instruction: Who makes the decisions for in-diviual patients?

Output: an MDT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who makes the decisions for in-diviual patients?. ### Response: an MDT.


Instruction: What are patients with severe AS and severe primary MR best treated with?

Output: SAVR and mitral valve surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients with severe AS and severe primary MR best treated with?. ### Response: SAVR and mitral valve surgery.


Instruction: What is best treated unless the surgical risk is high or prohibitive?

Output: patients with severe AS and severe primary MR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is best treated unless the surgical risk is high or prohibitive?. ### Response: patients with severe AS and severe primary MR.


Instruction: A staged procedure with TAVI followed by mitral TEER can be effective if there is severe what?

Output: high or prohibitive surgical risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A staged procedure with TAVI followed by mitral TEER can be effective if there is severe what?. ### Response: high or prohibitive surgical risk.


Instruction: What can be effective if there is severe AS and severe secondary MR?

Output: SAVR and mitral valve surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be effective if there is severe AS and severe secondary MR?. ### Response: SAVR and mitral valve surgery.


Instruction: What is one of the largest RASi studies?

Output: The HOPE study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the largest RASi studies?. ### Response: The HOPE study.


Instruction: What did the HOPE study report in people at high CVrisk with or without high BP?

Output: CV bene ﬁts with an ACEi versus placebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the HOPE study report in people at high CVrisk with or without high BP?. ### Response: CV bene ﬁts with an ACEi versus placebo.


Instruction: How many patients with no or mildly increased albuminuria were in the prespeci fied CKD sub-group?

Output: 3394

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with no or mildly increased albuminuria were in the prespeci fied CKD sub-group?. ### Response: 3394.


Instruction: How much did ACEire reduce the risk for all-cause mortality?

Output: 20%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much did ACEire reduce the risk for all-cause mortality?. ### Response: 20%.


Instruction: What was the mean follow-up of patients with no or mildly increased albuminuria?

Output: 4.5 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean follow-up of patients with no or mildly increased albuminuria?. ### Response: 4.5 years.


Instruction: How long did the HOPEstudy last?

Output: 4.5 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the HOPEstudy last?. ### Response: 4.5 years.


Instruction: How many patients had diabetes in the overall study?

Output: 3577

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had diabetes in the overall study?. ### Response: 3577.


Instruction: What percentage of the patients with diabetes did not have albuminuria?

Output: 2437

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the patients with diabetes did not have albuminuria?. ### Response: 2437.


Instruction: What should beadministered using the highest approved dose that istolerated to achieve the bene fits described?

Output: RASi

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should beadministered using the highest approved dose that istolerated to achieve the bene fits described?. ### Response: RASi.


Instruction: The Work Group judged that a large majority of physicians would be comfortable initiating what?

Output: RAS blockade treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The Work Group judged that a large majority of physicians would be comfortable initiating what?. ### Response: RAS blockade treatment.


Instruction: What does RAS blockade do?

Output: in-hibits the action of aldosterone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does RAS blockade do?. ### Response: in-hibits the action of aldosterone.


Instruction: What is the benefit of RASi given in less than recommended doses?

Output: less certain

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the benefit of RASi given in less than recommended doses?. ### Response: less certain.


Instruction: Who is familiar with the drug?

Output: physicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is familiar with the drug?. ### Response: physicians.


Instruction: What are less certain in less thanmaximally recommended doses?

Output: bene ﬁts from RASi

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are less certain in less thanmaximally recommended doses?. ### Response: bene ﬁts from RASi.


Instruction: What may still be reasonable if the patient cannot tolerate the maximum dose?

Output: a smaller dose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may still be reasonable if the patient cannot tolerate the maximum dose?. ### Response: a smaller dose.


Instruction: The maximum dose of RASi allowed by theregulatory agency varies by what country?

Output: country

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The maximum dose of RASi allowed by theregulatory agency varies by what country?. ### Response: country.


Instruction: What are two potent antihypertensive drugs?

Output: ACEi and ARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are two potent antihypertensive drugs?. ### Response: ACEi and ARBs.


Instruction: When should changes in BP, serum creatinine, andserum potassium be checked?

Output: within 2 –4 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When should changes in BP, serum creatinine, andserum potassium be checked?. ### Response: within 2 –4 weeks.


Instruction: What are potent antihypertensive agents that counteract the vasoconstrictive effects of angiotensin II?

Output: ACEi and ARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are potent antihypertensive agents that counteract the vasoconstrictive effects of angiotensin II?. ### Response: ACEi and ARBs.


Instruction: What causes selec-tively greater vas-odilatation of the efferent arterioles of theglomeruli?

Output: blocking the action of angiotensin II

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes selec-tively greater vas-odilatation of the efferent arterioles of theglomeruli?. ### Response: blocking the action of angiotensin II.


Instruction: What causes a decrease in the GFR and a rise in the serum creatinine?

Output: blocking the action of angiotensin II

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes a decrease in the GFR and a rise in the serum creatinine?. ### Response: blocking the action of angiotensin II.


Instruction: What blockade inhibits the action of aldosterone?

Output: RAS blockade

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What blockade inhibits the action of aldosterone?. ### Response: RAS blockade.


Instruction: What is recommended before and at 1 – 2 weeks after initiation of RASi?

Output: measuring serum potassium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended before and at 1 – 2 weeks after initiation of RASi?. ### Response: measuring serum potassium.


Instruction: What will typically occur during the first 2 weeks of treatment initiation?

Output: An increase in serum creatinine level

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will typically occur during the first 2 weeks of treatment initiation?. ### Response: An increase in serum creatinine level.


Instruction: How long should patients be monitored for symptomatic hypotension, hyperkalemia, andserum creatinine after initiating or changing the dose of the drug?

Output: 2 –4 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long should patients be monitored for symptomatic hypotension, hyperkalemia, andserum creatinine after initiating or changing the dose of the drug?. ### Response: 2 –4 weeks.


Instruction: How long did it take for aspirin to cause a first major vascular event?

Output: 10 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for aspirin to cause a first major vascular event?. ### Response: 10 years.


Instruction: What was the RR of this study?

Output: 3.72

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the RR of this study?. ### Response: 3.72.


Instruction: How much reduction in the risk of stroke did this study find in men?

Output: ≥ 10%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much reduction in the risk of stroke did this study find in men?. ### Response: ≥ 10%.


Instruction: What was the RR of women in this study?

Output: 0.76

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the RR of women in this study?. ### Response: 0.76.


Instruction: How much of a reduction in stroke risk was found in women?

Output: 17%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of a reduction in stroke risk was found in women?. ### Response: 17%.


Instruction: The RR reduction was based on a 24% reduction in what?

Output: the risk of ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The RR reduction was based on a 24% reduction in what?. ### Response: the risk of ischemic stroke.


Instruction: What was the RR of aspirin-treated women?

Output: 0.76

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the RR of aspirin-treated women?. ### Response: 0.76.


Instruction: What was a nonsignificant increase in the risk of hemorrhagic stroke?

Output: RR, 1.24

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a nonsignificant increase in the risk of hemorrhagic stroke?. ### Response: RR, 1.24.


Instruction: How much reduction in risk of ischemic stroke was there?

Output: 24%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much reduction in risk of ischemic stroke was there?. ### Response: 24%.


Instruction: What was 0.13%/y in placebo-treated females?

Output: stroke rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was 0.13%/y in placebo-treated females?. ### Response: stroke rates.


Instruction: How was gastrointestinal hemorrhage requiring transfusion more frequent in the placebo group?

Output: 0.05%/y

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was gastrointestinal hemorrhage requiring transfusion more frequent in the placebo group?. ### Response: 0.05%/y.


Instruction: The RR was 1.40; 95% CI, 1.07–1.83; P =0.02.

Output: hem-orrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The RR was 1.40; 95% CI, 1.07–1.83; P =0.02.. ### Response: hem-orrhage.


Instruction: What was the absolute risk increase for aspirin?

Output: 0.01%/y

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the absolute risk increase for aspirin?. ### Response: 0.01%/y.


Instruction: How much was the RR for placebo?

Output: 0.05%/y

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much was the RR for placebo?. ### Response: 0.05%/y.


Instruction: Who had the most consistent benefit?

Output: women ≥ 65 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who had the most consistent benefit?. ### Response: women ≥ 65 years of age.


Instruction: What was reduced by 26% among women  65 years of age at study entry?

Output: the risk of major cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was reduced by 26% among women  65 years of age at study entry?. ### Response: the risk of major cardiovascular events.


Instruction: How much was the risk of major cardiovascular events reduced?

Output: 26%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much was the risk of major cardiovascular events reduced?. ### Response: 26%.


Instruction: What was the RR of ischemic stroke reduced by 30%?

Output: 0.70

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the RR of ischemic stroke reduced by 30%?. ### Response: 0.70.


Instruction: How much did a reduction in the overall risk of all types of stroke occur?

Output: a trend

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much did a reduction in the overall risk of all types of stroke occur?. ### Response: a trend.


Instruction: What was the RR of women with a history of hypertension?

Output: 0.76

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the RR of women with a history of hypertension?. ### Response: 0.76.


Instruction: What was the RR for hypertension?

Output: 0.76

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the RR for hypertension?. ### Response: 0.76.


Instruction: What was RR of diabetes mellitus?

Output: 0.46

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was RR of diabetes mellitus?. ### Response: 0.46.


Instruction: How long was the cardio-vascular risk  10%?

Output: 10-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the cardio-vascular risk  10%?. ### Response: 10-year.


Instruction: What did a post hoc subgroup WHS analysis find about aspirin use in women with migraine?

Output: the over -all effect of aspirin was not modified

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a post hoc subgroup WHS analysis find about aspirin use in women with migraine?. ### Response: the over -all effect of aspirin was not modified.


Instruction: What was associated with an increased risk of MI in those with migraine with aura?

Output: aspirin use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with an increased risk of MI in those with migraine with aura?. ### Response: aspirin use.