Instruction: How much of patients present with acute MI and 25% with UA?

Output: 5% to 10%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of patients present with acute MI and 25% with UA?. ### Response: 5% to 10%.


Instruction: What are some of the factors associated with an increased risk of restenosis invarious models?

Output: clinical setting (STEMI, ACS, dailyangina

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the factors associated with an increased risk of restenosis invarious models?. ### Response: clinical setting (STEMI, ACS, dailyangina.


Instruction: What is the minimum stent diameter /H113492.5 mm?

Output: total stent length/H1135040 mm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the minimum stent diameter /H113492.5 mm?. ### Response: total stent length/H1135040 mm.


Instruction: What is the total stent length?

Output: H1135040 mm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the total stent length?. ### Response: H1135040 mm.


Instruction: What are the strategies for treating restenosis after balloon angioplasty, BMS, and DES reviewed in the following sections?

Output: PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the strategies for treating restenosis after balloon angioplasty, BMS, and DES reviewed in the following sections?. ### Response: PCI.


Instruction: What is not appropriate if the patient is not able to comply with and tolerate DAPT?

Output: Repeat PCI with BMS or DES

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not appropriate if the patient is not able to comply with and tolerate DAPT?. ### Response: Repeat PCI with BMS or DES.


Instruction: What is stent implan-tation?

Output: superior to repeat balloon angioplasty or atheroab-lation devices

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is stent implan-tation?. ### Response: superior to repeat balloon angioplasty or atheroab-lation devices.


Instruction: What is superior to repeat balloon angioplasty or atheroab-lation devices?

Output: stent implan-tation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is superior to repeat balloon angioplasty or atheroab-lation devices?. ### Response: stent implan-tation.


Instruction: What was the target-lesion revascularization rate for stent-treated patients?

Output: 10%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the target-lesion revascularization rate for stent-treated patients?. ### Response: 10%.


Instruction: What type of lesions are included in Pattern I?

Output: focal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of lesions are included in Pattern I?. ### Response: focal.


Instruction: What is included in-stent restenosis/H1102210 mmwithin the stent?

Output: Pattern II

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is included in-stent restenosis/H1102210 mmwithin the stent?. ### Response: Pattern II.


Instruction: Pattern III includes what type of resteno-sis?

Output: in-stent restenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Pattern III includes what type of resteno-sis?. ### Response: in-stent restenosis.


Instruction: In-stent restenosis treated with balloon angioplasty, repeat BMS or atheroablationdevices for Patterns I to IV resulted in 1-year target-lesionrevascularization rates of what?

Output: 19%, 35%, 50%, and 83%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In-stent restenosis treated with balloon angioplasty, repeat BMS or atheroablationdevices for Patterns I to IV resulted in 1-year target-lesionrevascularization rates of what?. ### Response: 19%, 35%, 50%, and 83%,.


Instruction: For clinical restenosis after BMS, repeat stenting with what is preferred?

Output: DES

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For clinical restenosis after BMS, repeat stenting with what is preferred?. ### Response: DES.


Instruction: What have shown lower recurrentrestenosis rates with DES compared with BMS or vascularbrachytherapy?

Output: Studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have shown lower recurrentrestenosis rates with DES compared with BMS or vascularbrachytherapy?. ### Response: Studies.


Instruction: Restenosis After DESClinical restenosis after placement of DES is becoming more common due to the large numbers of patients who have been treated with what?

Output: DES

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Restenosis After DESClinical restenosis after placement of DES is becoming more common due to the large numbers of patients who have been treated with what?. ### Response: DES.


Instruction: What is the predominant angio-graphic pattern for DES in-stent restennosis?

Output: focal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the predominant angio-graphic pattern for DES in-stent restennosis?. ### Response: focal.


Instruction: What is hypertrophic cardiomyopathy?

Output: diagnosis and treatment of patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hypertrophic cardiomyopathy?. ### Response: diagnosis and treatment of patients.


Instruction: What is ESC guidelines on the management of during pregnancy?

Output: cardiovascular diseases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ESC guidelines on the management of during pregnancy?. ### Response: cardiovascular diseases.


Instruction: What is the Task Force on the Management of Cardiovascular Diseases during Pregnancy of the European Society of Cardiology called?

Output: ESC guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Task Force on the Management of Cardiovascular Diseases during Pregnancy of the European Society of Cardiology called?. ### Response: ESC guidelines.


Instruction: When was the Eur Heart J.32:3147-97 published?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Eur Heart J.32:3147-97 published?. ### Response: 2011.


Instruction: What are the 2018 ESC guidelines for the management of?

Output: cardiovascular diseases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the 2018 ESC guidelines for the management of?. ### Response: cardiovascular diseases.


Instruction: What are ESC guidelines for the management of during preg-nancy?

Output: cardiovascular diseases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are ESC guidelines for the management of during preg-nancy?. ### Response: cardiovascular diseases.


Instruction: What is the 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines?

Output: Antithrombotic and thrombolytic therapy for valvular disease: Antithrombotic Therapy and Prevention of Thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines?. ### Response: Antithrombotic and thrombolytic therapy for valvular disease: Antithrombotic Therapy and Prevention of Thrombosis.


Instruction: What is the acronym for College of Chest Physicians Evidence-Based Clinical Practice Guidelines?

Output: American

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for College of Chest Physicians Evidence-Based Clinical Practice Guidelines?. ### Response: American.


Instruction: What are the 2017 ESC/EACTS guidelines for the management of?

Output: valvular heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the 2017 ESC/EACTS guidelines for the management of?. ### Response: valvular heart disease.


Instruction: What is the name of the 2017 ESC/EACTS guidelines for the management of valvular heart disease?

Output: Baumgartner

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2017 ESC/EACTS guidelines for the management of valvular heart disease?. ### Response: Baumgartner.


Instruction: What was the 2013 ACCF/AHA guideline?

Output: management of heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 2013 ACCF/AHA guideline?. ### Response: management of heart failure.


Instruction: What was the name of the Task Force on Clinical Practice Guidelines?

Output: American College of Cardiology/American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the Task Force on Clinical Practice Guidelines?. ### Response: American College of Cardiology/American Heart Association.


Instruction: What is the Class of Recommendation and Level of Evidence?

Output: 1. ACCF/AHA Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Class of Recommendation and Level of Evidence?. ### Response: 1. ACCF/AHA Task Force on Practice Guidelines.


Instruction: What is the name of the Task Force on Practice Guidelines?

Output: ACCF/AHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Practice Guidelines?. ### Response: ACCF/AHA.


Instruction: When was the Manual and Policies From the ACCF/AHA Task Force On Practice Guidelines released?

Output: August 19, 2020

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Manual and Policies From the ACCF/AHA Task Force On Practice Guidelines released?. ### Response: August 19, 2020.


Instruction: What are the GENERAL PRINCIPLES2.3?

Output: Diagnosis and Follow-Up

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the GENERAL PRINCIPLES2.3?. ### Response: Diagnosis and Follow-Up.


Instruction: What does EAE/ASE recommend for clinical practice?

Output: Echocardiographic assessment of valve stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does EAE/ASE recommend for clinical practice?. ### Response: Echocardiographic assessment of valve stenosis.


Instruction: What is the Eur J Echocardiogr. 2009:1–25?

Output: Echocardiographic assessment of valve stenosis: EAE/ASE recommendations for clinical practice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Eur J Echocardiogr. 2009:1–25?. ### Response: Echocardiographic assessment of valve stenosis: EAE/ASE recommendations for clinical practice.


Instruction: Who developed recommendations for noninva-sive evaluation of native valvular regurgitation?

Output: Ameri-can Society of Echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who developed recommendations for noninva-sive evaluation of native valvular regurgitation?. ### Response: Ameri-can Society of Echocardiography.


Instruction: Who developed the Ameri-can Society of Echocardiography?

Output: Society for Cardiovascular Magnetic Resonance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who developed the Ameri-can Society of Echocardiography?. ### Response: Society for Cardiovascular Magnetic Resonance.


Instruction: What was developed in collaboration with the Society for Cardiovascular Magnetic Resonance?

Output: Ameri-can Society of Echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was developed in collaboration with the Society for Cardiovascular Magnetic Resonance?. ### Response: Ameri-can Society of Echocardiography.


Instruction: When did J Am Soc Echocardiogr. 2017;30:303–71?

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J Am Soc Echocardiogr. 2017;30:303–71?. ### Response: 2017.


Instruction: What is regurgitation?

Output: native valve disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is regurgitation?. ### Response: native valve disease.


Instruction: What is mitral and tricuspid regurgitation?

Output: native valve disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is mitral and tricuspid regurgitation?. ### Response: native valve disease.


Instruction: When was the Eur J Echo-cardiogr. 2010?

Output: 11:307–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Eur J Echo-cardiogr. 2010?. ### Response: 11:307–.


Instruction: What will be incorporated into future revisions or updates of the full-text guideline?

Output: The individual recommenda-tions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will be incorporated into future revisions or updates of the full-text guideline?. ### Response: The individual recommenda-tions.


Instruction: Who were invited to participate in this focused update?

Output: representative members of the 2012 stable ischemic heart disease (SIHD) guideline writing com-mittee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who were invited to participate in this focused update?. ### Response: representative members of the 2012 stable ischemic heart disease (SIHD) guideline writing com-mittee.


Instruction: What is SIHD?

Output: stable ischemic heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SIHD?. ### Response: stable ischemic heart disease.


Instruction: What was the 2014 focused update writing group referred to as?

Output: 2012 stable ischemic heart disease (SIHD) guideline writing com-mittee were invited to participate, and they were joined by addi-tional invited members to form a new writing group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 2014 focused update writing group referred to as?. ### Response: 2012 stable ischemic heart disease (SIHD) guideline writing com-mittee were invited to participate, and they were joined by addi-tional invited members to form a new writing group.


Instruction: What were guideline writing committee invited to participate in?

Output: focused update

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were guideline writing committee invited to participate in?. ### Response: focused update.


Instruction: How many official reviewers did the document receive?

Output: 5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many official reviewers did the document receive?. ### Response: 5.


Instruction: How many individual reviewers reviewed the document?

Output: 5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many individual reviewers reviewed the document?. ### Response: 5.


Instruction: How many individual content were downloaded from http://ahajournals.org by May 1, 2023?

Output: 33

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many individual content were downloaded from http://ahajournals.org by May 1, 2023?. ### Response: 33.


Instruction: What type of surgery is indicated in asymptomatic patients with severe rheumatic MS?

Output: PMBC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of surgery is indicated in asymptomatic patients with severe rheumatic MS?. ### Response: PMBC.


Instruction: How large is the mitral valve area in Stage C patients?

Output: ≤1.5 cm2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How large is the mitral valve area in Stage C patients?. ### Response: ≤1.5 cm2.


Instruction: What is a reasonable PMBC if it can be performed at a Comprehensive Valve Center?

Output: In asymptomatic patients with severe rheumatic MS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a reasonable PMBC if it can be performed at a Comprehensive Valve Center?. ### Response: In asymptomatic patients with severe rheumatic MS.


Instruction: What is the mitral valve area 1.5 cm2?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the mitral valve area 1.5 cm2?. ### Response: ≤.


Instruction: What type of MS has a mitral valve area 1.5 cm2, Stage C?

Output: severe rheumatic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of MS has a mitral valve area 1.5 cm2, Stage C?. ### Response: severe rheumatic.


Instruction: PMBC may be considered if it can be performed at a Comprehensive Valve Center.

Output: asymptomatic patients with severe rheumatic MS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: PMBC may be considered if it can be performed at a Comprehensive Valve Center.. ### Response: asymptomatic patients with severe rheumatic MS.


Instruction: Where is the Comprehensive Valve Center located?

Output: 142b C-LD4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the Comprehensive Valve Center located?. ### Response: 142b C-LD4.


Instruction: What is the mitral valve area of a symptomatic patient with rheumatic MS?

Output: ≤1.5 cm2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the mitral valve area of a symptomatic patient with rheumatic MS?. ### Response: ≤1.5 cm2.


Instruction: What is the mean mitral valve gradient during exercise?

Output: >15 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the mean mitral valve gradient during exercise?. ### Response: >15 mm Hg.


Instruction: Where can PMBC be performed?

Output: Comprehensive Valve Center

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can PMBC be performed?. ### Response: Comprehensive Valve Center.


Instruction: What type of MS is PMBC considered?

Output: rheumatic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of MS is PMBC considered?. ### Response: rheumatic.


Instruction: What type of MS has a suboptimal valve anatomy?

Output: rheumatic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of MS has a suboptimal valve anatomy?. ### Response: rheumatic.


Instruction: PMBC may be considered if it can be performed at a Comprehensive Valve Center?

Output: asymptomatic patients with severe rheumatic MS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: PMBC may be considered if it can be performed at a Comprehensive Valve Center?. ### Response: asymptomatic patients with severe rheumatic MS.


Instruction: What is the optimal treatment for patients with rheumatic MS?

Output: PMBC or surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the optimal treatment for patients with rheumatic MS?. ### Response: PMBC or surgery.


Instruction: Where can PMBC or surgery be performed?

Output: experienced centers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can PMBC or surgery be performed?. ### Response: experienced centers.


Instruction: What can be performed at a Comprehensive Valve Center?

Output: PMBC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be performed at a Comprehensive Valve Center?. ### Response: PMBC.


Instruction: What type of procedure is used to relieve stenosis?

Output: splitting open fused commissures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of procedure is used to relieve stenosis?. ### Response: splitting open fused commissures.


Instruction: How much has the use of commissurotomy decreased in the U.S.?

Output: 7.5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much has the use of commissurotomy decreased in the U.S.?. ### Response: 7.5%.


Instruction: What is the name of the procedure that involves splitting open fused commissures?

Output: PMBC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the procedure that involves splitting open fused commissures?. ### Response: PMBC.


Instruction: What has been a decrease in the use of PMBC in the US?

Output: 7.5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been a decrease in the use of PMBC in the US?. ### Response: 7.5%.


Instruction: What is the increase in complica-tion rate?

Output: 15.9%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the increase in complica-tion rate?. ### Response: 15.9%.


Instruction: How is commissurotomy performed in the United States?

Output: routinely or widely performed by most surgeons

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is commissurotomy performed in the United States?. ### Response: routinely or widely performed by most surgeons.


Instruction: What is an option for treatment only if there is no other option and the patient has what?

Output: severe limiting symptoms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an option for treatment only if there is no other option and the patient has what?. ### Response: severe limiting symptoms.


Instruction: What is essential in the clinical decision-making process for a patient with rheumatic MS?

Output: know the results of the available interventional procedures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is essential in the clinical decision-making process for a patient with rheumatic MS?. ### Response: know the results of the available interventional procedures.


Instruction: What does PMBC have compared to surgical closed or open commissurotomy in patients with rheumatic MS?

Output: safety and efficacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does PMBC have compared to surgical closed or open commissurotomy in patients with rheumatic MS?. ### Response: safety and efficacy.


Instruction: What type of studies have established the safety and efficacy of PMBC?

Output: Randomized trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of studies have established the safety and efficacy of PMBC?. ### Response: Randomized trials.


Instruction: What type of MS is Intervention for?

Output: Rheumatic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of MS is Intervention for?. ### Response: Rheumatic.


Instruction: When was Intervention for Rheumatic MSDownloaded from http://ahajournals.org

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Intervention for Rheumatic MSDownloaded from http://ahajournals.org. ### Response: April 28, 2023.


Instruction: What type of anticoagulants are recommended?

Output: NOACs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of anticoagulants are recommended?. ### Response: NOACs.


Instruction: What is the name of the new factor Xa inhibitor?

Output: edoxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the new factor Xa inhibitor?. ### Response: edoxaban.


Instruction: What has not been updated for greater granularity as per the new LOE system?

Output: The LOEs for warfarin, dabigatran, rivaroxaban, and apixaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has not been updated for greater granularity as per the new LOE system?. ### Response: The LOEs for warfarin, dabigatran, rivaroxaban, and apixaban.


Instruction: What is the original text of the 2014 AF Guideline?

Output: Section 4.1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the original text of the 2014 AF Guideline?. ### Response: Section 4.1.


Instruction: Where can the original text of the 2014 AF guideline be found?

Output: Section 4.1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can the original text of the 2014 AF guideline be found?. ### Response: Section 4.1.


Instruction: What is additional information about the comparative effectiveness and bleeding risk of NOACs found in Section 4.2.2.2.BBBB-RI A2?

Output: the direct thrombin inhibitor and factor Xa inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is additional information about the comparative effectiveness and bleeding risk of NOACs found in Section 4.2.2.2.BBBB-RI A2?. ### Response: the direct thrombin inhibitor and factor Xa inhibitors.


Instruction: What drugs are recommended over warfarin in NOAC-eligible patients with AF?

Output: dabigatran, rivaroxaban,  apixaban, and edoxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drugs are recommended over warfarin in NOAC-eligible patients with AF?. ### Response: dabigatran, rivaroxaban,  apixaban, and edoxaban.


Instruction: Exclusion criteria are now defined as what?

Output: moderate-to-severe mitral stenosis or a mechanical heart valve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Exclusion criteria are now defined as what?. ### Response: moderate-to-severe mitral stenosis or a mechanical heart valve.


Instruction: What is the direct thrombin inhibitor?

Output: factor Xa inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the direct thrombin inhibitor?. ### Response: factor Xa inhibitors.


Instruction: What were the direct thrombin inhibitor and factor Xa inhibitors superior to in some trials?

Output: warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the direct thrombin inhibitor and factor Xa inhibitors superior to in some trials?. ### Response: warfarin.


Instruction: What was associated with lower risks of serious bleeding in patients treated with warfarin?

Output: factor Xa inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with lower risks of serious bleeding in patients treated with warfarin?. ### Response: factor Xa inhibitors.


Instruction: What should be determined at least weekly during initiation of anticoagulant therapy?

Output: international normalized ratio (INR)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be determined at least weekly during initiation of anticoagulant therapy?. ### Response: international normalized ratio (INR).


Instruction: When should the international normalized ratio (INR) be determined?

Output: at least weekly during initiation of anticoagulant therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When should the international normalized ratio (INR) be determined?. ### Response: at least weekly during initiation of anticoagulant therapy.


Instruction: What was changed to "antithrombotic"?

Output: anticoagulant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was changed to "antithrombotic"?. ### Response: anticoagulant.


Instruction: What is recommended for assessment of stroke risk in patients with AF?

Output: CHA2DS2-VASc score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for assessment of stroke risk in patients with AF?. ### Response: CHA2DS2-VASc score.


Instruction: What are the exclusion criteria now defined as?

Output: moderate-to-severe mitral stenosis or a mechanical heart valve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the exclusion criteria now defined as?. ### Response: moderate-to-severe mitral stenosis or a mechanical heart valve.


Instruction: How are patients treated with bioprosthetic heart valves?

Output: addressed in the supportive text

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are patients treated with bioprosthetic heart valves?. ### Response: addressed in the supportive text.


Instruction: What are addressed in the supportive text?

Output: Patients with AF with bioprosthetic heart valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are addressed in the supportive text?. ### Response: Patients with AF with bioprosthetic heart valves.


Instruction: What is recommended for patients with AF who have mechanical heart valves?

Output: warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for patients with AF who have mechanical heart valves?. ### Response: warfarin.


Instruction: When was the support text downloaded?

Output: April 23, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the support text downloaded?. ### Response: April 23, 2023.


Instruction: What is pregnancy in women with mechanical heart valve prostheses?

Output: Anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is pregnancy in women with mechanical heart valve prostheses?. ### Response: Anticoagulation.


Instruction: What is hepa-rin used for in pregnant women?

Output: mechanical heart valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hepa-rin used for in pregnant women?. ### Response: mechanical heart valves.


Instruction: How is enoxaparin treated in women with mechanical heart valves during pregnancy?

Output: Low molecular weight heparin for the pro-phylaxis of thromboembolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is enoxaparin treated in women with mechanical heart valves during pregnancy?. ### Response: Low molecular weight heparin for the pro-phylaxis of thromboembolism.


Instruction: What is thromboprophylaxis with low molecular weight heparin?

Output: Management of preg-nant women with mechanical heart valve prosthesis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is thromboprophylaxis with low molecular weight heparin?. ### Response: Management of preg-nant women with mechanical heart valve prosthesis.


Instruction: What is the name of the European Society of Cardiology Registry of Pregnancy and Cardiac Disease?

Output: ROPAC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the European Society of Cardiology Registry of Pregnancy and Cardiac Disease?. ### Response: ROPAC.


Instruction: What does ROPAC stand for?

Output: European Society of Cardi-ology Registry of Pregnancy and Cardiac Disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ROPAC stand for?. ### Response: European Society of Cardi-ology Registry of Pregnancy and Cardiac Disease.


Instruction: What is the name of the 2015 issue of Circulation?

Output: 132:132–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2015 issue of Circulation?. ### Response: 132:132–.


Instruction: Who is the author of ROPAC?

Output: van Hagen IM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of ROPAC?. ### Response: van Hagen IM.


Instruction: How is anti-Xa monitored in pregnancy?

Output: peak or trough levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is anti-Xa monitored in pregnancy?. ### Response: peak or trough levels.


Instruction: What does the UKOSS stand for?

Output: United Kingdom Obstetric Surveillance System

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the UKOSS stand for?. ### Response: United Kingdom Obstetric Surveillance System.


Instruction: What is the name of the prospective population based study?

Output: Pregnancy outcomes in women with mechanical prosthetic heart valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective population based study?. ### Response: Pregnancy outcomes in women with mechanical prosthetic heart valves.


Instruction: What is the UKOSS?

Output: United Kingdom Obstetric Surveillance System

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the UKOSS?. ### Response: United Kingdom Obstetric Surveillance System.


Instruction: What is low molecular weight heparin used for?

Output: pro-phylaxis of thromboembolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is low molecular weight heparin used for?. ### Response: pro-phylaxis of thromboembolism.


Instruction: What is one of the outcomes of anticoagulation in pregnant women with mechanical heart valves?

Output: Maternal and fetal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the outcomes of anticoagulation in pregnant women with mechanical heart valves?. ### Response: Maternal and fetal.


Instruction: What is the name of the journal that studies the effects on the fetal and maternal outcomes?

Output: Am J Cardiol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies the effects on the fetal and maternal outcomes?. ### Response: Am J Cardiol.


Instruction: How many pregnant women were diagnosed with heart valve complications in 2004?

Output: 747–51

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many pregnant women were diagnosed with heart valve complications in 2004?. ### Response: 747–51.


Instruction: What type of heart valves are pregnant women with?

Output: mechanical prosthetic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of heart valves are pregnant women with?. ### Response: mechanical prosthetic.


Instruction: What is the name of the medical journal that studies the effects of warfarin on the fetus?

Output: J Am Coll Cardiol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the medical journal that studies the effects of warfarin on the fetus?. ### Response: J Am Coll Cardiol.


Instruction: When did the J Am Coll Cardiol issue 33:1637–41?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the J Am Coll Cardiol issue 33:1637–41?. ### Response: 1999.


Instruction: What is the name of the device used to treat anticoagulation in pregnant women with mechanical heart valve prostheses?

Output: Elkayam U

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the device used to treat anticoagulation in pregnant women with mechanical heart valve prostheses?. ### Response: Elkayam U.


Instruction: When did Heart. 1999:82:23-6?

Output: 20

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Heart. 1999:82:23-6?. ### Response: 20.


Instruction: What are the names of the devices used for pregnancy outcomes and cardiac complications?

Output: biologic and mechanical valve prostheses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the devices used for pregnancy outcomes and cardiac complications?. ### Response: biologic and mechanical valve prostheses.


Instruction: What is the name of the fourth edition of the American Soci-ety of Regional Anesthesia and Pain Medicine?

Output: evidence-based guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the fourth edition of the American Soci-ety of Regional Anesthesia and Pain Medicine?. ### Response: evidence-based guidelines.


Instruction: What are the names of the authors of the 2004 edition of BJOG?

Output: Goland S, Schwartzenberg S, Fan J, et al. Monitoring of anti-Xa in preg-nant patients with mechanical prosthetic valves receiving low-molecular-weight heparin: peak or trough levels? J Cardiovasc Pharmacol Ther. 2014;19:451–6. 13. Elkayam U. Anticoagulation therapy for pregnant women with mechani-cal prosthetic heart valves: how to improve safety? J Am Coll Cardiol. 2017;69:2692–5. 14. Vause S, Clarke B, Tower CL, et al. Pregnancy outcomes in women with mechanical prosthetic heart valves: a prospective descriptive population based study using the United Kingdom Obstetric Surveillance System (UKOSS) data collection system. BJOG. 2017;124:1411–9. 15. Oran B, Lee-Parritz A, Ansell J

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the authors of the 2004 edition of BJOG?. ### Response: Goland S, Schwartzenberg S, Fan J, et al. Monitoring of anti-Xa in preg-nant patients with mechanical prosthetic valves receiving low-molecular-weight heparin: peak or trough levels? J Cardiovasc Pharmacol Ther. 2014;19:451–6. 13. Elkayam U. Anticoagulation therapy for pregnant women with mechani-cal prosthetic heart valves: how to improve safety? J Am Coll Cardiol. 2017;69:2692–5. 14. Vause S, Clarke B, Tower CL, et al. Pregnancy outcomes in women with mechanical prosthetic heart valves: a prospective descriptive population based study using the United Kingdom Obstetric Surveillance System (UKOSS) data collection system. BJOG. 2017;124:1411–9. 15. Oran B, Lee-Parritz A, Ansell J.


Instruction: What are the names of the authors of the paper?

Output: Abildgaard U, Sandset PM, Hammerstrøm J

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the authors of the paper?. ### Response: Abildgaard U, Sandset PM, Hammerstrøm J.


Instruction: What is the name of the study?

Output: European Society of Cardi-ology Registry of Pregnancy and Cardiac Disease (ROPAC).

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study?. ### Response: European Society of Cardi-ology Registry of Pregnancy and Cardiac Disease (ROPAC)..


Instruction: What could be useful in patients with SIHD who have /H110223% risk of mortality per year?

Output: Yearly exercise testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could be useful in patients with SIHD who have /H110223% risk of mortality per year?. ### Response: Yearly exercise testing.


Instruction: Why would a marked decrease in exercise capacity be useful?

Output: can warrant reevaluation of the medicalregimen or interventional plan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why would a marked decrease in exercise capacity be useful?. ### Response: can warrant reevaluation of the medicalregimen or interventional plan.


Instruction: What can warrant a reevaluation of the medicalregimen or interventional plan?

Output: a marked decrease in exercise capacity or a marked increasein ischemic burden

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can warrant a reevaluation of the medicalregimen or interventional plan?. ### Response: a marked decrease in exercise capacity or a marked increasein ischemic burden.


Instruction: What is an example of a high-risk Duke treadmill score?

Output: patients with anEF/H1102150% and significant CAD in /H110221 major vessel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a high-risk Duke treadmill score?. ### Response: patients with anEF/H1102150% and significant CAD in /H110221 major vessel.


Instruction: What was the overall event-free survival rate in patients with/H113505% reduction in ischemic myocardium in a substudy of the COURAGE trial?

Output: 86.6%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the overall event-free survival rate in patients with/H113505% reduction in ischemic myocardium in a substudy of the COURAGE trial?. ### Response: 86.6%.


Instruction: Patients with diabetes mellitus and those with multivessel disease have not undergone what?

Output: CABG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with diabetes mellitus and those with multivessel disease have not undergone what?. ### Response: CABG.


Instruction: What was the rate of reduction in ischemic myocardium in patients with a H113505% reduction?

Output: 86.6%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the rate of reduction in ischemic myocardium in patients with a H113505% reduction?. ### Response: 86.6%.


Instruction: What is the rate in patients without a significant reduction of ischemia burden after 6 to 18 months?

Output: 75.3%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the rate in patients without a significant reduction of ischemia burden after 6 to 18 months?. ### Response: 75.3%.


Instruction: The results of the BARI 2D trial are similar to what?

Output: patients with high myocardialjeopardy scores randomized to CABG had fewer cardiovas-cular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The results of the BARI 2D trial are similar to what?. ### Response: patients with high myocardialjeopardy scores randomized to CABG had fewer cardiovas-cular events.


Instruction: What did the BARI 2D trial show?

Output: patients with high myocardialjeopardy scores randomized to CABG had fewer cardiovas-cular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the BARI 2D trial show?. ### Response: patients with high myocardialjeopardy scores randomized to CABG had fewer cardiovas-cular events.


Instruction: Patients with high myocardialjeopardy scores randomized to CABG had fewer cardiovascular events than those with highscores who received only medical therapy?

Output: 276

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with high myocardialjeopardy scores randomized to CABG had fewer cardiovascular events than those with highscores who received only medical therapy?. ### Response: 276.


Instruction: What was the composite endpoint of all-causemortality or MI?

Output: cardiovas-cular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the composite endpoint of all-causemortality or MI?. ### Response: cardiovas-cular events.


Instruction: What is the relative hazard for patients with multiple clinical risk factors and negative stress imagingstudies?

Output: cardiac death or MI canincrease after a 2-year follow-up time period

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the relative hazard for patients with multiple clinical risk factors and negative stress imagingstudies?. ### Response: cardiac death or MI canincrease after a 2-year follow-up time period.


Instruction: How does durability of information gained from a stress test overtime vary?

Output: widely according to the characteristics of thepatients and the type of test performed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does durability of information gained from a stress test overtime vary?. ### Response: widely according to the characteristics of thepatients and the type of test performed.


Instruction: What is the relative hazard for cardiac death or MI?

Output: increase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the relative hazard for cardiac death or MI?. ### Response: increase.


Instruction: What can increase after a 2-year follow-up time period?

Output: the risk of an adverse event

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can increase after a 2-year follow-up time period?. ### Response: the risk of an adverse event.


Instruction: How long can the risk remain low among other groups?

Output: through 2 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long can the risk remain low among other groups?. ### Response: through 2 years.


Instruction: What were the factors associated with an increased risk of diabetes mellitus?

Output: male sex,increased age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the factors associated with an increased risk of diabetes mellitus?. ### Response: male sex,increased age.


Instruction: What was the name of the large single-site study?

Output: COURAGE trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the large single-site study?. ### Response: COURAGE trial.


Instruction: How long did it take for an increase in risk to occur?

Output: 9 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for an increase in risk to occur?. ### Response: 9 years.


Instruction: How long did the risk of adverse cardiovascular events last?

Output: 9 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the risk of adverse cardiovascular events last?. ### Response: 9 years.


Instruction: What type of test was used in the study?

Output: pharmacologicalstress test

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of test was used in the study?. ### Response: pharmacologicalstress test.


Instruction: How many years was the annual risk of cardiovascular events predicted?

Output: 9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many years was the annual risk of cardiovascular events predicted?. ### Response: 9.


Instruction: How long did a man with a normal pharmaco-logical stress study have a risk of an adverse event?

Output: /H110221%in/H110211 year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did a man with a normal pharmaco-logical stress study have a risk of an adverse event?. ### Response: /H110221%in/H110211 year.


Instruction: What was the risk of a hard event in a 80-year-old man with an index-negative perfusion evaluation?

Output: /H110221%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk of a hard event in a 80-year-old man with an index-negative perfusion evaluation?. ### Response: /H110221%.


Instruction: What does index-negative perfusion evaluation do?

Output: risk of an adverse event rose to /H110221%in/H110211 year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does index-negative perfusion evaluation do?. ### Response: risk of an adverse event rose to /H110221%in/H110211 year.


Instruction: What is the utility of repeat stress testing in patients with known CAD?

Output: 6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the utility of repeat stress testing in patients with known CAD?. ### Response: 6.


Instruction: What can reduce the cost of medication for patients?

Output: scored tablets and pill cutters

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can reduce the cost of medication for patients?. ### Response: scored tablets and pill cutters.


Instruction: What is the recommendation for Structured, Team Based Care Interventions for Hypertension Control?

Output: Section 13

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommendation for Structured, Team Based Care Interventions for Hypertension Control?. ### Response: Section 13.


Instruction: What is a team-based care approach recommended for adults with hypertension?

Output: S12.2-1–S12.2-7Synopsis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a team-based care approach recommended for adults with hypertension?. ### Response: S12.2-1–S12.2-7Synopsis.


Instruction: What type of intervention incorporates a multidisciplinary team?

Output: Team-based care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of intervention incorporates a multidisciplinary team?. ### Response: Team-based care.


Instruction: What is an organizational intervention that incorporates a multidisciplinary team to improve the quality of hypertension care for patients?

Output: Team-based care to improve BP control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an organizational intervention that incorporates a multidisciplinary team to improve the quality of hypertension care for patients?. ### Response: Team-based care to improve BP control.


Instruction: What has been shown to increase the proportion of individuals with controlled BP and reduce both SBP and DBP?

Output: team-based hyper -tension care models

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been shown to increase the proportion of individuals with controlled BP and reduce both SBP and DBP?. ### Response: team-based hyper -tension care models.


Instruction: A team-based care approach is what?

Output: patient centered

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A team-based care approach is what?. ### Response: patient centered.


Instruction: What is a team-based care approach?

Output: patient centered

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a team-based care approach?. ### Response: patient centered.


Instruction: What is the patient's primary focus in team based care for hypertension?

Output: primary care provider

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the patient's primary focus in team based care for hypertension?. ### Response: primary care provider.


Instruction: Who is often implemented as part of a multifaceted approach to hypertension care?

Output: team-based care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is often implemented as part of a multifaceted approach to hypertension care?. ### Response: team-based care.


Instruction: What type of care includes the patient, the patient's primary care provider, and other professionals?

Output: Team-based care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of care includes the patient, the patient's primary care provider, and other professionals?. ### Response: Team-based care.


Instruction: Cardiologists, nurses, pharma-cists, physician assistants, dietitians, social workers, and community health workers complement the activities of what?

Output: Team-based care for hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cardiologists, nurses, pharma-cists, physician assistants, dietitians, social workers, and community health workers complement the activities of what?. ### Response: Team-based care for hypertension.


Instruction: What is Section 13 of the Online Data Supplement H.S12.2-3 Delineation?

Output: a comprehensive, patient-centered plan of care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Section 13 of the Online Data Supplement H.S12.2-3 Delineation?. ### Response: a comprehensive, patient-centered plan of care.


Instruction: What should be the basis of all team-based care?

Output: patient-centered plan of care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be the basis of all team-based care?. ### Response: patient-centered plan of care.


Instruction: What allows a pri-mary care provider to delegate routine matters to the team?

Output: Delineation of individual team member roles

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What allows a pri-mary care provider to delegate routine matters to the team?. ### Response: Delineation of individual team member roles.


Instruction: What allows the patient to have more time to manage complex and complex matters?

Output: Delineation of individual team member roles on the basis of knowledge, skill set, and availability, as well as the patient’s needs, allows the pri-mary care provider to delegate routine matters to the team

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What allows the patient to have more time to manage complex and complex matters?. ### Response: Delineation of individual team member roles on the basis of knowledge, skill set, and availability, as well as the patient’s needs, allows the pri-mary care provider to delegate routine matters to the team.


Instruction: What is the role of team members related to medication management?

Output: multidisciplinary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of team members related to medication management?. ### Response: multidisciplinary.


Instruction: What should be clear to all team members?

Output: Team member roles

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be clear to all team members?. ### Response: Team member roles.


Instruction: What should be clear to all team members and to patients and families?

Output: Team member roles

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be clear to all team members and to patients and families?. ### Response: Team member roles.


Instruction: Team-based care often requires organizational change and reallocation of what?

Output: resources

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Team-based care often requires organizational change and reallocation of what?. ### Response: resources.


Instruction: What is one system-level sup-port?

Output: treatment algorithms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one system-level sup-port?. ### Response: treatment algorithms.


Instruction: What is likely to augment and intensify team-based care efforts to reduce high BP?

Output: self-management support tools, and monitoring of performance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is likely to augment and intensify team-based care efforts to reduce high BP?. ### Response: self-management support tools, and monitoring of performance.


Instruction: What are treatment algo-rithms?

Output: clinical decision support

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are treatment algo-rithms?. ### Response: clinical decision support.


Instruction: What is a critical appraisal tool for systematic reviews that include randomised or non-randomised studies?

Output: AMSTAR 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a critical appraisal tool for systematic reviews that include randomised or non-randomised studies?. ### Response: AMSTAR 2.


Instruction: What is a revised tool for the quality assessment of diagnostic accuracy studies?

Output: QUADAS-2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a revised tool for the quality assessment of diagnostic accuracy studies?. ### Response: QUADAS-2.


Instruction: What is the name of the systematic review that includes randomised or non-randomised studies of healthcare interventions?

Output: AMSTAR 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review that includes randomised or non-randomised studies of healthcare interventions?. ### Response: AMSTAR 2.


Instruction: What are the GRADE guidelines?

Output: a newseries of articles in the Journal of Clinical Epidemiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the GRADE guidelines?. ### Response: a newseries of articles in the Journal of Clinical Epidemiology.


Instruction: What is a GRADE guideline?

Output: a newseries of articles in the Journal of Clinical Epidemiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a GRADE guideline?. ### Response: a newseries of articles in the Journal of Clinical Epidemiology.


Instruction: How many GRADE guides are there?

Output: 10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many GRADE guides are there?. ### Response: 10.


Instruction: How many GRADE guidelines are there?

Output: 10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many GRADE guidelines are there?. ### Response: 10.


Instruction: What is the purpose of GRADE?

Output: a newseries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of GRADE?. ### Response: a newseries.


Instruction: Where is Kidney International located?

Output: 2021) 99

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Kidney International located?. ### Response: 2021) 99.


Instruction: What is the COR of IIa for PCSK9 inhibitors?

Output: acknowledging effi-cacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the COR of IIa for PCSK9 inhibitors?. ### Response: acknowledging effi-cacy.


Instruction: What are the 2018 Cholesterol Clinical Practice Guidelines?

Output: composite ASCVD events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the 2018 Cholesterol Clinical Practice Guidelines?. ### Response: composite ASCVD events.


Instruction: How many large RCTs showed reductions in ASCVD events in patients who had very high levels of antibodies?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many large RCTs showed reductions in ASCVD events in patients who had very high levels of antibodies?. ### Response: 2.


Instruction: Why is long-term tolerance of expensive monoclonal antibodies inconvenient?

Output: it requires repetitive admin-istration via the parenteral route

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is long-term tolerance of expensive monoclonal antibodies inconvenient?. ### Response: it requires repetitive admin-istration via the parenteral route.


Instruction: How many alternative pathways are there to initiation of PCSK9 inhibitors?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many alternative pathways are there to initiation of PCSK9 inhibitors?. ### Response: 2.


Instruction: What was the strategy of (a) statin + ezetimibe before PCSK9 inhibitor graded as?

Output: COR I

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the strategy of (a) statin + ezetimibe before PCSK9 inhibitor graded as?. ### Response: COR I.


Instruction: What was graded COR I for reasons given in Recommendation 3?

Output: The strategy of (a) statin + ezetimibe before PCSK9 inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was graded COR I for reasons given in Recommendation 3?. ### Response: The strategy of (a) statin + ezetimibe before PCSK9 inhibitor.


Instruction: What strategy would expose more patients to the inconvenience of antibody therapy and reduce overall cost effectiveness?

Output: exclud-ing ezetimibe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What strategy would expose more patients to the inconvenience of antibody therapy and reduce overall cost effectiveness?. ### Response: exclud-ing ezetimibe.


Instruction: What should clinical judgment be used to determine if de-intensification of lipid lowering regimen is warranted as long-term?

Output: safety of such low levels of LDL-C remains unknown

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should clinical judgment be used to determine if de-intensification of lipid lowering regimen is warranted as long-term?. ### Response: safety of such low levels of LDL-C remains unknown.


Instruction: What is the long-term safety of low levels of LDL-C?

Output: unknown

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the long-term safety of low levels of LDL-C?. ### Response: unknown.


Instruction: What is IMPROVE-IT?

Output: Improved Reduction of Outcomes: Vytorin Efficacy International Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is IMPROVE-IT?. ### Response: Improved Reduction of Outcomes: Vytorin Efficacy International Trial.


Instruction: How did ezetimibe compare to statin therapy?

Output: moderate-intensity statin therapy among patients with ACS and LDL-C levels ≥50 mg/dL (≥1.3 mmol/L) resulted in a significant ASCVD risk reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did ezetimibe compare to statin therapy?. ### Response: moderate-intensity statin therapy among patients with ACS and LDL-C levels ≥50 mg/dL (≥1.3 mmol/L) resulted in a significant ASCVD risk reduction.


Instruction: What was the median follow-up for ASCVD?

Output: 6 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the median follow-up for ASCVD?. ### Response: 6 years.


Instruction: What is the acronym for Thrombolysis in Myocardial Infarction?

Output: TIMI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Thrombolysis in Myocardial Infarction?. ### Response: TIMI.


Instruction: The TIMI is based on what?

Output: Thrombolysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The TIMI is based on what?. ### Response: Thrombolysis.


Instruction: What is Secondary Prevention?

Output: an integer-based risk stratification tool for patients with ASCVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Secondary Prevention?. ### Response: an integer-based risk stratification tool for patients with ASCVD.


Instruction: What is secondary prevention?

Output: an integer-based risk stratification tool for patients with ASCVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is secondary prevention?. ### Response: an integer-based risk stratification tool for patients with ASCVD.


Instruction: How many readily avail-able clinical high-risk features does TRS 2°P have?

Output: 9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many readily avail-able clinical high-risk features does TRS 2°P have?. ### Response: 9.


Instruction: What was associated with a higher risk of recurrent ASCVD events?

Output: higher number of these high-risk features

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with a higher risk of recurrent ASCVD events?. ### Response: higher number of these high-risk features.


Instruction: In post-ACS patients with 3 high-risk features, adding ezetimibe had what effect?

Output: substantial risk reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In post-ACS patients with 3 high-risk features, adding ezetimibe had what effect?. ### Response: substantial risk reduction.


Instruction: What percentage of RRR was associated with substantial risk reduction?

Output: 7%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of RRR was associated with substantial risk reduction?. ### Response: 7%.


Instruction: How many high-risk features had some benefit?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many high-risk features had some benefit?. ### Response: 2.


Instruction: What was the number needed to treat?

Output: 16

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the number needed to treat?. ### Response: 16.


Instruction: Who had no benefit from ezetimibe?

Output: those with 0 or 1 addi-tional features

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who had no benefit from ezetimibe?. ### Response: those with 0 or 1 addi-tional features.


Instruction: What did the National Choles-terol Education Program’s Step I and Step II dietary intervention do?

Output: Effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the National Choles-terol Education Program’s Step I and Step II dietary intervention do?. ### Response: Effects.


Instruction: When was the paper published?

Output: May 1, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the paper published?. ### Response: May 1, 2023.


Instruction: Where did the paper come from?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where did the paper come from?. ### Response: http://ahajournals.org.


Instruction: How much did the primary composite end point increase in the first 3 months after CABG in the quinapril group (P=0.04)?

Output: significantly

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much did the primary composite end point increase in the first 3 months after CABG in the quinapril group (P=0.04)?. ### Response: significantly.


Instruction: What adverse events were also increased in the whonapil group during the first three postop-erative months?

Output: hypotension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What adverse events were also increased in the whonapil group during the first three postop-erative months?. ### Response: hypotension.


Instruction: In the select trial population, what is routine ACE inhibitor therapy used for?

Output: more harm than benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the select trial population, what is routine ACE inhibitor therapy used for?. ### Response: more harm than benefit.


Instruction: What did routine ACE inhibitor therapy lead to more harm than benefit when initiated early after CABG?

Output: select trial population

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did routine ACE inhibitor therapy lead to more harm than benefit when initiated early after CABG?. ### Response: select trial population.


Instruction: In patients who remain above the BP goal despite a suitably titrated regimen including a -blocker and if appro-priate what?

Output: an ACE inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients who remain above the BP goal despite a suitably titrated regimen including a -blocker and if appro-priate what?. ### Response: an ACE inhibitor.


Instruction: What can be considered as a next therapy choice?

Output: blocker or a diuretic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be considered as a next therapy choice?. ### Response: blocker or a diuretic.


Instruction: What can effectively reduce BP and prevent graft spasm?

Output: dihydropyridine calcium channel blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can effectively reduce BP and prevent graft spasm?. ### Response: dihydropyridine calcium channel blocker.


Instruction: A long-acting dihydropyridine calcium channel blocker can reduce what?

Output: BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A long-acting dihydropyridine calcium channel blocker can reduce what?. ### Response: BP.


Instruction: What is an antianginal effect?

Output: dihydropyridine calcium channel blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an antianginal effect?. ### Response: dihydropyridine calcium channel blocker.


Instruction: What are nondihydropyridine calcium channel blockers?

Output: verapamil and diltiazem

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are nondihydropyridine calcium channel blockers?. ### Response: verapamil and diltiazem.


Instruction: Verapamil and diltiazem are what type of antihypertensive agents?

Output: effec-tive

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Verapamil and diltiazem are what type of antihypertensive agents?. ### Response: effec-tive.


Instruction: What type of drugs are generally reserved for patients with renal function?

Output: thiazide-type drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of drugs are generally reserved for patients with renal function?. ### Response: thiazide-type drugs.


Instruction: What is a diuretic class based on?

Output: renal function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a diuretic class based on?. ### Response: renal function.


Instruction: What type of drugs are generally reserved for patients with a glomerular filtration rate >30 mL/min?

Output: thiazide-type drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of drugs are generally reserved for patients with a glomerular filtration rate >30 mL/min?. ### Response: thiazide-type drugs.


Instruction: What is no more common in the post-CABG patient than in the general hypertensive patient?

Output: Resistant hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is no more common in the post-CABG patient than in the general hypertensive patient?. ### Response: Resistant hypertension.


Instruction: What is common in the post-CABG patient than in the general hypertensive population?

Output: Resistant hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is common in the post-CABG patient than in the general hypertensive population?. ### Response: Resistant hypertension.


Instruction: What is the approach to treatment fairly similar to?

Output: Resistant hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the approach to treatment fairly similar to?. ### Response: Resistant hypertension.


Instruction: What are two compounds that reduce adrenergic activity?

Output: clonidine or doxazosin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are two compounds that reduce adrenergic activity?. ### Response: clonidine or doxazosin.


Instruction: What can be effective in lowering BP in the patient with resistant hypertension?

Output: a min-eralocorticoid receptor antagonist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be effective in lowering BP in the patient with resistant hypertension?. ### Response: a min-eralocorticoid receptor antagonist.


Instruction: What should be administered as soon as possible after CABG to reduce the risk of postoperative AF and to facili-tate BP control?

Output: β-Blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be administered as soon as possible after CABG to reduce the risk of postoperative AF and to facili-tate BP control?. ### Response: β-Blockers.


Instruction: What is the risk of postoperative AF and facili-tate BP control early after surgery?

Output: reduce

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of postoperative AF and facili-tate BP control early after surgery?. ### Response: reduce.


Instruction: What should be administered after CABG for patients with MI, LV dysfunction, diabetes mellitus, and chronic kidney disease?

Output: ACE inhibitor therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be administered after CABG for patients with MI, LV dysfunction, diabetes mellitus, and chronic kidney disease?. ### Response: ACE inhibitor therapy.


Instruction: What is considered in determining the timing of initiation and dose selection after surgery?

Output: renal function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is considered in determining the timing of initiation and dose selection after surgery?. ### Response: renal function.


Instruction: What is a class I; Level of Evidence B?

Output: ACE inhibitor therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a class I; Level of Evidence B?. ### Response: ACE inhibitor therapy.


Instruction: What is the LAPSS?

Output: Los Angeles Prehospital Stroke Screen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the LAPSS?. ### Response: Los Angeles Prehospital Stroke Screen.


Instruction: What is a Los Angeles Prehospital Stroke Screen?

Output: LAPSS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a Los Angeles Prehospital Stroke Screen?. ### Response: LAPSS.


Instruction: What is the acronym for the Recognition of Stroke in the Emergency Room scale?

Output: ROSIER

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the Recognition of Stroke in the Emergency Room scale?. ### Response: ROSIER.


Instruction: What was the name of the scale developed and validated by the Lancet Neurol in 2005?

Output: ROSIER)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the scale developed and validated by the Lancet Neurol in 2005?. ### Response: ROSIER).


Instruction: How many stroke referrals did the ROSIER scale provide?

Output: 30

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many stroke referrals did the ROSIER scale provide?. ### Response: 30.


Instruction: What is used to diagnose stroke referrals?

Output: face arm speech test

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used to diagnose stroke referrals?. ### Response: face arm speech test.


Instruction: What is the face arm speech test used for?

Output: Diagnostic accuracy of stroke referrals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the face arm speech test used for?. ### Response: Diagnostic accuracy of stroke referrals.


Instruction: How many strokes were reported in 2003?

Output: 71–76

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes were reported in 2003?. ### Response: 71–76.


Instruction: What is the name of the prehospital scale used to predict stroke severity?

Output: Cincinnati Prehospital Stroke Severity Scale

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prehospital scale used to predict stroke severity?. ### Response: Cincinnati Prehospital Stroke Severity Scale.


Instruction: How many strokes were diagnosed with the Cincinnati Prehospital Stroke Severity Scale?

Output: 32

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes were diagnosed with the Cincinnati Prehospital Stroke Severity Scale?. ### Response: 32.


Instruction: What is a simple and accu-rate prehospital stroke triage?

Output: Field assess-ment stroke triage for emergency destination

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a simple and accu-rate prehospital stroke triage?. ### Response: Field assess-ment stroke triage for emergency destination.


Instruction: What is a simple and accu-rate prehospital scale to detect?

Output: large vessel occlusion strokes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a simple and accu-rate prehospital scale to detect?. ### Response: large vessel occlusion strokes.


Instruction: What year did Stroke.47:1997-2002 occur?

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Stroke.47:1997-2002 occur?. ### Response: 2016.


Instruction: How many strokes were there between 1997 and 2002?

Output: 33

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes were there between 1997 and 2002?. ### Response: 33.


Instruction: What does the rapid arterial occlusion evaluation scale do?

Output: Predictive value of modifica-tions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the rapid arterial occlusion evaluation scale do?. ### Response: Predictive value of modifica-tions.


Instruction: What does Hastrup S, Damgaard D, Johnsen SP, Andersen G use?

Output: Prehospital acute stroke severity scale

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Hastrup S, Damgaard D, Johnsen SP, Andersen G use?. ### Response: Prehospital acute stroke severity scale.


Instruction: What is the purpose of the stroke severity scale?

Output: to predict large artery occlusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of the stroke severity scale?. ### Response: to predict large artery occlusion.


Instruction: What is a simple 3-item stroke scale to compare with the National Institutes of Health Stroke Scale?

Output: prediction of middle cerebral artery occlusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a simple 3-item stroke scale to compare with the National Institutes of Health Stroke Scale?. ### Response: prediction of middle cerebral artery occlusion.


Instruction: What does the National Institutes of Health Stroke Scale predict?

Output: middle cerebral artery occlusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the National Institutes of Health Stroke Scale predict?. ### Response: middle cerebral artery occlusion.


Instruction: What is a brief pre-hospital stroke severity scale?

Output: Cincinnati Prehospital Stroke Severity Scale

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a brief pre-hospital stroke severity scale?. ### Response: Cincinnati Prehospital Stroke Severity Scale.


Instruction: What does a brief pre-hospital stroke severity scale identify?

Output: ischemic stroke patients harbor -ing persisting large arterial occlusions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does a brief pre-hospital stroke severity scale identify?. ### Response: ischemic stroke patients harbor -ing persisting large arterial occlusions.


Instruction: What is the name of the scale that identifies ischemic stroke patients harboring persisting large arterial occlusions?

Output: pre-hospital stroke severity scale

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the scale that identifies ischemic stroke patients harboring persisting large arterial occlusions?. ### Response: pre-hospital stroke severity scale.


Instruction: When did Stroke. 2008;39:2264–2267?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Stroke. 2008;39:2264–2267?. ### Response: 2008.


Instruction: What is Pérez de la Ossa's title?

Output: N

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Pérez de la Ossa's title?. ### Response: N.


Instruction: What is the name of the scale that predicts large vessel occlusion in stroke patients?

Output: prehospital rapid arterial occlusion evaluation scale

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the scale that predicts large vessel occlusion in stroke patients?. ### Response: prehospital rapid arterial occlusion evaluation scale.


Instruction: How many strokes were there in 2017?

Output: 74–77

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes were there in 2017?. ### Response: 74–77.


Instruction: What is a significant change in their dietary intake of vitaminK-containing foods?

Output: there is a significant change in their dietary intake of vitaminK–containing foods.The panel identified the following additional research questions.(1) What is the comparative effectiveness of 6- to 12-week INRrecall intervals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a significant change in their dietary intake of vitaminK-containing foods?. ### Response: there is a significant change in their dietary intake of vitaminK–containing foods.The panel identified the following additional research questions.(1) What is the comparative effectiveness of 6- to 12-week INRrecall intervals.


Instruction: What is the comparative effectiveness of 6- to 12-week INR recall intervals compared with a 4-week recall interval in real-world patients during periods of stable INR control?

Output: What is the comparative effectiveness of 6- to 12-week INRrecall intervals compared with a 4-week recall interval in real-world patients during periods of stable INR control? Given thelow risk of adverse events in stable patients, a very large patientsample will likely be required to answer this question. (2) What isthe cost-effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the comparative effectiveness of 6- to 12-week INR recall intervals compared with a 4-week recall interval in real-world patients during periods of stable INR control?. ### Response: What is the comparative effectiveness of 6- to 12-week INRrecall intervals compared with a 4-week recall interval in real-world patients during periods of stable INR control? Given thelow risk of adverse events in stable patients, a very large patientsample will likely be required to answer this question. (2) What isthe cost-effectiveness.


Instruction: What is the cost-effectiveness of 6- to 12-week INR recall intervals compared with a 4-week recall interval from the societalperspective?

Output: comparative effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cost-effectiveness of 6- to 12-week INR recall intervals compared with a 4-week recall interval from the societalperspective?. ### Response: comparative effectiveness.


Instruction: What should clinicians monitor to guide LMWH dose adjustment?

Output: anti –factor Xa concentration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should clinicians monitor to guide LMWH dose adjustment?. ### Response: anti –factor Xa concentration.


Instruction: What is the recommended dose for patients with renal dysfunction with creatinine clearance of,30 mL/min?

Output: Recommendation 7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommended dose for patients with renal dysfunction with creatinine clearance of,30 mL/min?. ### Response: Recommendation 7.


Instruction: What is the creatinine clearance of patients with renal dysfunction?

Output: 30 mL/min

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the creatinine clearance of patients with renal dysfunction?. ### Response: 30 mL/min.


Instruction: What does the ASH guideline panel suggest against using?

Output: anti –factor Xaconcentration monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the ASH guideline panel suggest against using?. ### Response: anti –factor Xaconcentration monitoring.


Instruction: What should providers consider instead of monitor-ing anti-factor Xa concentrations?

Output: using doses adjusted for renal function as recommended inproduct labeling

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should providers consider instead of monitor-ing anti-factor Xa concentrations?. ### Response: using doses adjusted for renal function as recommended inproduct labeling.


Instruction: What is an alternative anticoagulant with lower renal clearance?

Output: UFH or adifferent LMWH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an alternative anticoagulant with lower renal clearance?. ### Response: UFH or adifferent LMWH.


Instruction: How many studies were included from the most recent systematic review of LMWH for patients with renaldysfunction?

Output: eligible studies fromthe most recent systematic review of LMWH for patients with renaldysfunction.84

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were included from the most recent systematic review of LMWH for patients with renaldysfunction?. ### Response: eligible studies fromthe most recent systematic review of LMWH for patients with renaldysfunction.84.


Instruction: When was the search updated to yield atotal of 11 studies?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the search updated to yield atotal of 11 studies?. ### Response: 2006.


Instruction: What did patients receiving LMWH with renal dysfunction have anti-Xa concentrations monitored?

Output: single-arm cohortstudies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did patients receiving LMWH with renal dysfunction have anti-Xa concentrations monitored?. ### Response: single-arm cohortstudies.


Instruction: What did the no-monitoring comparator group use to determine the risk of?

Output: major bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the no-monitoring comparator group use to determine the risk of?. ### Response: major bleeding.


Instruction: How often was enoxaparin administered subcutaneously?

Output: twice a day

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often was enoxaparin administered subcutaneously?. ### Response: twice a day.