Instruction: How many secondary prevention AFpatients were allocated to a conventional-intensity group?

Output: 115

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many secondary prevention AFpatients were allocated to a conventional-intensity group?. ### Response: 115.


Instruction: What is the INR range of 1.6-2.6)?

Output: alower target

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the INR range of 1.6-2.6)?. ### Response: alower target.


Instruction: In how many small prospectiverandomized trials were 115 secondary prevention patients allocated?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In how many small prospectiverandomized trials were 115 secondary prevention patients allocated?. ### Response: 1.


Instruction: How many major complications occurred in 6 Asian countries?

Output: 6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many major complications occurred in 6 Asian countries?. ### Response: 6.


Instruction: How many patients in the conventional-intensity group had majorhemorrhagic complications per year?

Output: 6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients in the conventional-intensity group had majorhemorrhagic complications per year?. ### Response: 6.


Instruction: What group had 0% per year of bleeding in its low intensity group?

Output: low-intensity group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What group had 0% per year of bleeding in its low intensity group?. ### Response: low-intensity group.


Instruction: How did Asian registries suggest that low intensity was associated with less bleeding?

Output: noinformation on quality of INR control was reported

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Asian registries suggest that low intensity was associated with less bleeding?. ### Response: noinformation on quality of INR control was reported.


Instruction: What was reported on quality of INR control?

Output: noinformation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was reported on quality of INR control?. ### Response: noinformation.


Instruction: There is currently no robust evidence for implementing what?

Output: INR control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is currently no robust evidence for implementing what?. ### Response: INR control.


Instruction: What did Roberts R, Rogers WJ, Mueller HS, et al. recommend following thrombolytic therapy in patients with acute myocardial infarction?

Output: Immediate versus deferred beta-blockade

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Roberts R, Rogers WJ, Mueller HS, et al. recommend following thrombolytic therapy in patients with acute myocardial infarction?. ### Response: Immediate versus deferred beta-blockade.


Instruction: What did the TIMI II-B Study do?

Output: Immediate versus deferred beta-blockade

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the TIMI II-B Study do?. ### Response: Immediate versus deferred beta-blockade.


Instruction: When was the Circulation. 1991;83:422–37?

Output: December 23/30, 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circulation. 1991;83:422–37?. ### Response: December 23/30, 2014.


Instruction: What is the name of the systematic review and meta regression analysis of beta blockade after myocar -dial infarction?

Output: BMJ. 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta regression analysis of beta blockade after myocar -dial infarction?. ### Response: BMJ. 1999.


Instruction: When did the BMJ issue 318:1730–7?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the BMJ issue 318:1730–7?. ### Response: 1999.


Instruction: What is a beta-blocker?

Output: ther -apy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a beta-blocker?. ### Response: ther -apy.


Instruction: How many patients had myocardial infarct treated with ther-apy?

Output: 45,852

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had myocardial infarct treated with ther-apy?. ### Response: 45,852.


Instruction: Infarction treated with acute beta-blocker ther -apy: results from the American College of Cardiology's NCDR((R)).

Output: myocardial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Infarction treated with acute beta-blocker ther -apy: results from the American College of Cardiology's NCDR((R)).. ### Response: myocardial.


Instruction: What is the name of the systematic review of selective and non-selective beta blockers for prevention of vascular events in patients with acute coronary syndrome?

Output: de Peuter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review of selective and non-selective beta blockers for prevention of vascular events in patients with acute coronary syndrome?. ### Response: de Peuter.


Instruction: How many patients with acute myocardial infarction were treated with early intravenous then oral meto-prolol?

Output: 45,852

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with acute myocardial infarction were treated with early intravenous then oral meto-prolol?. ### Response: 45,852.


Instruction: What is the name of the randomised placebo-controlled trial that evaluated 45,852 patients?

Output: CAPRICORN

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised placebo-controlled trial that evaluated 45,852 patients?. ### Response: CAPRICORN.


Instruction: When was the Lancet 366:1622–32?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Lancet 366:1622–32?. ### Response: 2005.


Instruction: What is carvedilol used for in patients with left-ventricular dysfunction?

Output: outcome after myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is carvedilol used for in patients with left-ventricular dysfunction?. ### Response: outcome after myocardial infarction.


Instruction: What is the CAPRICORN trial?

Output: randomised trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the CAPRICORN trial?. ### Response: randomised trial.


Instruction: What is the name of the randomised trial in patients with left-ventricular dysfunction?

Output: CAPRICORN

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised trial in patients with left-ventricular dysfunction?. ### Response: CAPRICORN.


Instruction: What is carvedilol antiarrhythmic effect after acute myocardial infarction?

Output: diltiazem

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is carvedilol antiarrhythmic effect after acute myocardial infarction?. ### Response: diltiazem.


Instruction: What is diltiazem and reinfarction in patients with non-Q-wave myocardial infarction?

Output: systemic hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is diltiazem and reinfarction in patients with non-Q-wave myocardial infarction?. ### Response: systemic hypertension.


Instruction: What is the effect of verapamil on mortality and major events after acute myocardial infarct?

Output: Antiarrhythmic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of verapamil on mortality and major events after acute myocardial infarct?. ### Response: Antiarrhythmic.


Instruction: When did a double-blind, randomized, multicenter trial take place?

Output: 1986

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did a double-blind, randomized, multicenter trial take place?. ### Response: 1986.


Instruction: What is the Danish Verapamil Infarction Trial II-DA VIT II?

Output: acute myocar -dial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Danish Verapamil Infarction Trial II-DA VIT II?. ### Response: acute myocar -dial infarction.


Instruction: What is diltiazem's effect on long-term outcome after acute myocardial infarction in patients with and without a history of systemic heart disease?

Output: Immediate versus deferred beta-blockade

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is diltiazem's effect on long-term outcome after acute myocardial infarction in patients with and without a history of systemic heart disease?. ### Response: Immediate versus deferred beta-blockade.


Instruction: Infarction in patients with and without a history of systemic hypertension?

Output: Effects of diltiazem

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Infarction in patients with and without a history of systemic hypertension?. ### Response: Effects of diltiazem.


Instruction: The Multicenter Diltiazem Postinfarction Trial Research Group. 1991; 68:429–33.

Output: Effects of diltiazem on long-term outcome after acute myocardial infarction in patients with and without a history of systemic hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The Multicenter Diltiazem Postinfarction Trial Research Group. 1991; 68:429–33.. ### Response: Effects of diltiazem on long-term outcome after acute myocardial infarction in patients with and without a history of systemic hypertension.


Instruction: What is Nifedipine's dose-related increase in mor-tality in?

Output: patients with coronary heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Nifedipine's dose-related increase in mor-tality in?. ### Response: patients with coronary heart disease.


Instruction: What is the name of the research group that investigated recurrent isch-aemia in patients treated with nifedipine or metoprolol?

Output: Holland Interuniversity Nifedipine/ Metoprolol Trial (HINT) Research Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the research group that investigated recurrent isch-aemia in patients treated with nifedipine or metoprolol?. ### Response: Holland Interuniversity Nifedipine/ Metoprolol Trial (HINT) Research Group.


Instruction: What is an example of an increasedcardiovascular risk?

Output: per-sons with known vascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of an increasedcardiovascular risk?. ### Response: per-sons with known vascular disease.


Instruction: What is the estimated glomerular filtration rate of older persons with chronic kidney disease?

Output: less than 45 mL/min/per 1.73m2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the estimated glomerular filtration rate of older persons with chronic kidney disease?. ### Response: less than 45 mL/min/per 1.73m2.


Instruction: What type of kidney disease excludes polycystic kidney disease?

Output: chronic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of kidney disease excludes polycystic kidney disease?. ### Response: chronic.


Instruction: What is the risk for car -diovascular disease for 10 years?

Output: 15% or greater

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk for car -diovascular disease for 10 years?. ### Response: 15% or greater.


Instruction: What is the 10-year risk for car -diovascular disease?

Output: 15% or greater

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 10-year risk for car -diovascular disease?. ### Response: 15% or greater.


Instruction: How old is the participant?

Output: 75 years or older

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old is the participant?. ### Response: 75 years or older.


Instruction: What was the target SBP in adults without diabetes or prior stroke?

Output: less than 120 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the target SBP in adults without diabetes or prior stroke?. ### Response: less than 120 mm Hg.


Instruction: How did Hg in adults without diabetes or prior stroke significantly reduce fatal and nonfatal cardiovascular events and all-cause mortality?

Output: targeting SBP to less than 120 mm Hg compared with lessthan 140 mm Hg in adults without diabetes or prior stroke, athigh-risk for cardiovascular disease, and with a baseline SBPof less than 140 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Hg in adults without diabetes or prior stroke significantly reduce fatal and nonfatal cardiovascular events and all-cause mortality?. ### Response: targeting SBP to less than 120 mm Hg compared with lessthan 140 mm Hg in adults without diabetes or prior stroke, athigh-risk for cardiovascular disease, and with a baseline SBPof less than 140 mm Hg.


Instruction: What did ACCORD (40) include only adults with type 2 diabetes athigh cardiovascular risk and found no statistically significant reduction?

Output: primary composite outcome of nonfatal myo-cardial infarction, nonfatal stroke, or death from cardiovascu-lar events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did ACCORD (40) include only adults with type 2 diabetes athigh cardiovascular risk and found no statistically significant reduction?. ### Response: primary composite outcome of nonfatal myo-cardial infarction, nonfatal stroke, or death from cardiovascu-lar events.


Instruction: What was the primary outcome of 2 diabetes at high cardiovascular risk?

Output: vascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary outcome of 2 diabetes at high cardiovascular risk?. ### Response: vascular disease.


Instruction: What is the RR of this study?

Output: 0.94

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the RR of this study?. ### Response: 0.94.


Instruction: What was the most serious adverse event associated with a SBP target of less than 120 mm Hg?

Output: cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the most serious adverse event associated with a SBP target of less than 120 mm Hg?. ### Response: cardiovascular disease.


Instruction: What is the lowest quality evidence of no statistically sig-nificant reduction in mortality, cardiac events or stroke?

Output: pooled estimates from all studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the lowest quality evidence of no statistically sig-nificant reduction in mortality, cardiac events or stroke?. ### Response: pooled estimates from all studies.


Instruction: What is important to evaluate the benefit of lower bloodpressuretargetsrelativetoharmsinpatientsage60yearsandolder?

Output: an individualized as-sessment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is important to evaluate the benefit of lower bloodpressuretargetsrelativetoharmsinpatientsage60yearsandolder?. ### Response: an individualized as-sessment.


Instruction: What is a reasonable goal for some patients with increased cardiovascular risk?

Output: An SBP target ofless than 140 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a reasonable goal for some patients with increased cardiovascular risk?. ### Response: An SBP target ofless than 140 mm Hg.


Instruction: What factors are unique to each patient?

Output: comorbidity,medication burden, risk for adverse events, and cost

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What factors are unique to each patient?. ### Response: comorbidity,medication burden, risk for adverse events, and cost.


Instruction: Who should individually assess cardiovascular risk for patients?

Output: Clini-cians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should individually assess cardiovascular risk for patients?. ### Response: Clini-cians.


Instruction: What should clini-cians individually assess for patients?

Output: cardiovascular risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should clini-cians individually assess for patients?. ### Response: cardiovascular risk.


Instruction: Most patients with what type of disease have increased cardiovascular risk?

Output: diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Most patients with what type of disease have increased cardiovascular risk?. ### Response: diabetes.


Instruction: What is the glomerular filtration rate less than?

Output: 45 mL/min/per 1.73m2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the glomerular filtration rate less than?. ### Response: 45 mL/min/per 1.73m2.


Instruction: What is the name of the randomised placebo-controlled trial of simvastatin and ezetimibe in patients with chronic kidney disease?

Output: Study of Heart and Renal Protection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised placebo-controlled trial of simvastatin and ezetimibe in patients with chronic kidney disease?. ### Response: Study of Heart and Renal Protection.


Instruction: When was the trial downloaded from http://ahajournals.org by?

Output: May 1, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the trial downloaded from http://ahajournals.org by?. ### Response: May 1, 2023.


Instruction: What is the dose of the drug based on?

Output: baseline BP, serum creatinine, and serum potassium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the dose of the drug based on?. ### Response: baseline BP, serum creatinine, and serum potassium.


Instruction: What is a shortertime interval indicated if the baseline serum creatinine ishigh?

Output: 4 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a shortertime interval indicated if the baseline serum creatinine ishigh?. ### Response: 4 weeks.


Instruction: How can hyperkalemia associated with use of RASi be managed?

Output: newer oral potassium binders

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can hyperkalemia associated with use of RASi be managed?. ### Response: newer oral potassium binders.


Instruction: What can be managed by measures to reduce theserum potassium levels rather than decreasing the dose?

Output: Hyperkalemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be managed by measures to reduce theserum potassium levels rather than decreasing the dose?. ### Response: Hyperkalemia.


Instruction: Hyperkalemia is often associated with a subsequent reduction in dose or discontinuation of what?

Output: RASi

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hyperkalemia is often associated with a subsequent reduction in dose or discontinuation of what?. ### Response: RASi.


Instruction: What type of hyperkalemia needs to be first ruled out?

Output: Pseudo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of hyperkalemia needs to be first ruled out?. ### Response: Pseudo.


Instruction: What could lead to increased use of RASi in patients with evidence-based indication?

Output: Improvement in potassiumcontrol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could lead to increased use of RASi in patients with evidence-based indication?. ### Response: Improvement in potassiumcontrol.


Instruction: What are some strategies to control chronichyperkalemia?

Output: dietary potassium restriction; discon-tinuation of potassium supplements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some strategies to control chronichyperkalemia?. ### Response: dietary potassium restriction; discon-tinuation of potassium supplements.


Instruction: What can be controlled with newer oral potassium binders in CKD patients?

Output: hyperkalemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be controlled with newer oral potassium binders in CKD patients?. ### Response: hyperkalemia.


Instruction: What is the current DIAMOND trial?

Output: NCT03888066

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the current DIAMOND trial?. ### Response: NCT03888066.


Instruction: What are the side effects of newer potassium binders reported to be?

Output: moderate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the side effects of newer potassium binders reported to be?. ### Response: moderate.


Instruction: What is a reasonable option for many patients treated with RASi?

Output: Practice Point 3.2.5: Continue ACEi or ARB therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a reasonable option for many patients treated with RASi?. ### Response: Practice Point 3.2.5: Continue ACEi or ARB therapy.


Instruction: How many patients were treated with RASi?

Output: many

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with RASi?. ### Response: many.


Instruction: What did there not be a single trial that compared meaningfulclinical outcomes in patients who were continuing versus dis-continuing versus reducing the dose?

Output: RASi

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did there not be a single trial that compared meaningfulclinical outcomes in patients who were continuing versus dis-continuing versus reducing the dose?. ### Response: RASi.


Instruction: What does an increase of 30% in serumcreatinine from the baseline value not mandate?

Output: dosagedecrease or discontinuation of RASi

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does an increase of 30% in serumcreatinine from the baseline value not mandate?. ### Response: dosagedecrease or discontinuation of RASi.


Instruction: What is not associated with an increase in serum creatinine?

Output: hyperkalemia and ﬂuid retention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not associated with an increase in serum creatinine?. ### Response: hyperkalemia and ﬂuid retention.


Instruction: What is not associated with other complications such as hyperkalemia and fluid retention?

Output: serumcreatinine increase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not associated with other complications such as hyperkalemia and fluid retention?. ### Response: serumcreatinine increase.


Instruction: What should you consider reducing the dose or dis-continuing in the setting of symp-tomatic hypotension or uncontrolled hyperkalemic hypotension?

Output: ACEi or ARB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should you consider reducing the dose or dis-continuing in the setting of symp-tomatic hypotension or uncontrolled hyperkalemic hypotension?. ### Response: ACEi or ARB.


Instruction: What should be reduced or dis-continued in patients with hyperkalemia after other measures failed to achieve a normal serum potassium level?

Output: The dose of ACEi or ARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be reduced or dis-continued in patients with hyperkalemia after other measures failed to achieve a normal serum potassium level?. ### Response: The dose of ACEi or ARBs.


Instruction: What did Lord L, Dowswell G, Hewison A study of change in heart failure services at three acute NHS trusts?

Output: The team for both sides

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Lord L, Dowswell G, Hewison A study of change in heart failure services at three acute NHS trusts?. ### Response: The team for both sides.


Instruction: What did Lubien E, DeMaria A, Krishnaswamy P, Clopton P, Koo n J, and Koo N J do?

Output: detecting diastolic dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Lubien E, DeMaria A, Krishnaswamy P, Clopton P, Koo n J, and Koo N J do?. ### Response: detecting diastolic dysfunction.


Instruction: What is the name of the peptide that detects diastolic dysfunction?

Output: B -natriuretic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the peptide that detects diastolic dysfunction?. ### Response: B -natriuretic.


Instruction: What is a comparison of the B-natriuretic Peptide with Doppler velocity recordings?

Output: Utility of B -natriuretic peptide in detecting diastolic dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a comparison of the B-natriuretic Peptide with Doppler velocity recordings?. ### Response: Utility of B -natriuretic peptide in detecting diastolic dysfunction.


Instruction: When was Circulation published?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Circulation published?. ### Response: 2002.


Instruction: What is the name of the randomized controlled trial of weight monitoring in patients with severe heart failure?

Output: WISH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized controlled trial of weight monitoring in patients with severe heart failure?. ### Response: WISH.


Instruction: What is the VA/DoD Clinical Practice Guideline for the Diagnosis and Management of Hypertensi on in the Primary Care Setting March 2020 Page 93 of 134 2014 Location 2014 Recommendation Text 2014 Strength of Recommandation Category 2020?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for the Diagnosis and Management of Hypertensi on in the Primary Care Setting March 2020 Page 93 of 134 2014 Location 2014 Recommendation Text 2014 Strength of Recommandation Category 2020?. ### Response: 2004.


Instruction: What does 2020 Recommendation Section Number Page 4.1 24 p. 39 We recommend offering pharmacologic treatment for patients 30 years and older with a diastolic blood pressure 90 mmHg?

Output: Strong f or Not reviewed, Deleted

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does 2020 Recommendation Section Number Page 4.1 24 p. 39 We recommend offering pharmacologic treatment for patients 30 years and older with a diastolic blood pressure 90 mmHg?. ### Response: Strong f or Not reviewed, Deleted.


Instruction: What age range do we suggest offering pharmacologic treatment for?

Output: 18 to 29

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What age range do we suggest offering pharmacologic treatment for?. ### Response: 18 to 29.


Instruction: What is the diastolic blood pressure 90 mmHg?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the diastolic blood pressure 90 mmHg?. ### Response: ≥.


Instruction: For patients 60 years and over, we recommend treating to what?

Output: a systolic blood pressure goal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For patients 60 years and over, we recommend treating to what?. ### Response: a systolic blood pressure goal.


Instruction: What is the systolic blood pressure goal for patients 60 years and over?

Output: <150 mmHg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the systolic blood pressure goal for patients 60 years and over?. ### Response: <150 mmHg.


Instruction: What is a strong f or Reviewed, Amended Recommendation 7 4.2 27 p. 40

Output: Strong f or Reviewed, Amended  Recommendation 7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a strong f or Reviewed, Amended Recommendation 7 4.2 27 p. 40. ### Response: Strong f or Reviewed, Amended  Recommendation 7.


Instruction: What is the systolic blood pressure goal?

Output: <140 mmHg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the systolic blood pressure goal?. ### Response: <140 mmHg.


Instruction: How old is the patient who is recommended to have a diastol blood pressure target?

Output: 30 years and older.  Strong f or Reviewed, Amended  Recommenda tion 9  4.2 29 p. 41  We suggest treating to a diastolic blood pressure goal <90 mmHg in patients age 18 to 29

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old is the patient who is recommended to have a diastol blood pressure target?. ### Response: 30 years and older.  Strong f or Reviewed, Amended  Recommenda tion 9  4.2 29 p. 41  We suggest treating to a diastolic blood pressure goal <90 mmHg in patients age 18 to 29.


Instruction: What is a strong f or Reviewed, Deleted?

Output: -- 4.3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a strong f or Reviewed, Deleted?. ### Response: -- 4.3.


Instruction: What is the diastolic blood pressure goal in patients 18 to 29?

Output: <90 mmHg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the diastolic blood pressure goal in patients 18 to 29?. ### Response: <90 mmHg.


Instruction: What is a weak f or Reviewed, Amended Recommenda tion 9 4.2 29 p. 41 We suggest treating to what in patients?

Output: follow -up at least annually, or more frequently as indicated, depending on patient preference. (Modified from 2004 VA/DoD HTN CPG without an updated systematic review of the evidence.)  Weak f or Reviewed, Deleted  -- 4.4 35 p. 48  We suggest taking into consideration the patient’s baseline blood pressure and presence of comorbidities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a weak f or Reviewed, Amended Recommenda tion 9 4.2 29 p. 41 We suggest treating to what in patients?. ### Response: follow -up at least annually, or more frequently as indicated, depending on patient preference. (Modified from 2004 VA/DoD HTN CPG without an updated systematic review of the evidence.)  Weak f or Reviewed, Deleted  -- 4.4 35 p. 48  We suggest taking into consideration the patient’s baseline blood pressure and presence of comorbidities.


Instruction: What is the systolic blood pressure goal for patients with diabetes?

Output: <140 mmHg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the systolic blood pressure goal for patients with diabetes?. ### Response: <140 mmHg.


Instruction: What is a strong f or Reviewed, Amended Recommendation 7?

Output: Deleted

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a strong f or Reviewed, Amended Recommendation 7?. ### Response: Deleted.


Instruction: What is the systolic blood pressure goal for diabetic patients?

Output: <140 mmHg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the systolic blood pressure goal for diabetic patients?. ### Response: <140 mmHg.


Instruction: What is a goal for patients with diabetes who tolerate antihypertensives?

Output: <140 mmHg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a goal for patients with diabetes who tolerate antihypertensives?. ### Response: <140 mmHg.


Instruction: What is the diastolic blood pressure goal for diabetic patients?

Output: <85 mmHg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the diastolic blood pressure goal for diabetic patients?. ### Response: <85 mmHg.


Instruction: How long after initiation of lifestyle or pharmacological therapy should patients be seen?

Output: one month

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after initiation of lifestyle or pharmacological therapy should patients be seen?. ### Response: one month.


Instruction: What is used to determine adequacy of hypertension control, degree of patient adherence, and presence of adverse effects?

Output: systematic review of the evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used to determine adequacy of hypertension control, degree of patient adherence, and presence of adverse effects?. ### Response: systematic review of the evidence.


Instruction: When was the VA/DoD HTN CPG updated?

Output: March 2020

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the VA/DoD HTN CPG updated?. ### Response: March 2020.


Instruction: What does VA/DoD HTN CPG not have an updated systematic review of?

Output: the evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does VA/DoD HTN CPG not have an updated systematic review of?. ### Response: the evidence.


Instruction: How often do we suggest follow-up?

Output: at least annually

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often do we suggest follow-up?. ### Response: at least annually.


Instruction: What does systematic review of the evidence do?

Output: offering pharmacologic treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does systematic review of the evidence do?. ### Response: offering pharmacologic treatment.


Instruction: What does VA/DoD suggest when deciding on monotherapy or combination therapy?

Output: taking into consideration the patient’s baseline blood pressure and presence of comorbidities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does VA/DoD suggest when deciding on monotherapy or combination therapy?. ### Response: taking into consideration the patient’s baseline blood pressure and presence of comorbidities.


Instruction: How many drugs are used when initiating drug therapy?

Output: two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many drugs are used when initiating drug therapy?. ### Response: two.


Instruction: What is ATTEST?

Output: a phase 2, randomised, open-label, blinded endpoint study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ATTEST?. ### Response: a phase 2, randomised, open-label, blinded endpoint study.


Instruction: What is the name of the phase 2 randomised, open-label, blinded endpoint study?

Output: ATTEST

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the phase 2 randomised, open-label, blinded endpoint study?. ### Response: ATTEST.


Instruction: What is the name of the randomized trial of tenecteplase versus alteplasa for acute ischemic stroke?

Output: NOR-TEST

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized trial of tenecteplase versus alteplasa for acute ischemic stroke?. ### Response: NOR-TEST.


Instruction: What is a name for the reversal of a randomized randomized study?

Output: AS-4 Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a name for the reversal of a randomized randomized study?. ### Response: AS-4 Trial.


Instruction: When was the N Engl J Med 366:1099-1107?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the N Engl J Med 366:1099-1107?. ### Response: 2012.


Instruction: Who are the Tenecteplase in Stroke Investigators?

Output: Haley EC Jr, Thompson JL, Grotta JC, Lyden PD, Hemmen TG, Brown DL, Fanale C, Libman R, Kwiatkowski TG, Llinas RH, et al;

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who are the Tenecteplase in Stroke Investigators?. ### Response: Haley EC Jr, Thompson JL, Grotta JC, Lyden PD, Hemmen TG, Brown DL, Fanale C, Libman R, Kwiatkowski TG, Llinas RH, et al;.


Instruction: What is the name of the Phase IIB/III trial?

Output: Tenecteplase in Stroke Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Phase IIB/III trial?. ### Response: Tenecteplase in Stroke Investigators.


Instruction: When did the randomized clinical trial of tenectepase begin?

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the randomized clinical trial of tenectepase begin?. ### Response: 2017.


Instruction: What is NOR-TEST?

Output: Tenecteplase versus alteplase for management of acute ischaemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NOR-TEST?. ### Response: Tenecteplase versus alteplase for management of acute ischaemic stroke.


Instruction: What is the name of the phase 3 trial?

Output: NOR-TEST

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the phase 3 trial?. ### Response: NOR-TEST.


Instruction: What is the name of the study that evaluated intravenous desmoteplase in patients with acute ischaemic stroke?

Output: DIAS Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated intravenous desmoteplase in patients with acute ischaemic stroke?. ### Response: DIAS Study Group.


Instruction: What is another name for MRI perfusion-diffusion weighted imaging or perfusion CT?

Output: DIAS-2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for MRI perfusion-diffusion weighted imaging or perfusion CT?. ### Response: DIAS-2.


Instruction: What is another name for imaging or perfusion CT?

Output: DIAS-2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for imaging or perfusion CT?. ### Response: DIAS-2.


Instruction: What is a prospective, randomised, double-blind, placebo-controlled study?

Output: Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2):

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a prospective, randomised, double-blind, placebo-controlled study?. ### Response: Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2):.


Instruction: When did the Lancet Neurol. 2009:8:141–150?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Lancet Neurol. 2009:8:141–150?. ### Response: 2009.


Instruction: What is the purpose of the DIAS Study Group?

Output: a prospective, randomised, double-blind, placebo-controlled study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of the DIAS Study Group?. ### Response: a prospective, randomised, double-blind, placebo-controlled study.


Instruction: What is a phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase?

Output: The Desmoteplase in Acute Ischemic Stroke Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase?. ### Response: The Desmoteplase in Acute Ischemic Stroke Trial.


Instruction: How long after major artery occlusion stroke does Desmoteplase last?

Output: 3 to 9 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after major artery occlusion stroke does Desmoteplase last?. ### Response: 3 to 9 hours.


Instruction: What is the name of the trial?

Output: NOR-TEST

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the trial?. ### Response: NOR-TEST.


Instruction: How long does it take for Desmotaplasa to treat Acute Ischemic Stroke?

Output: 9-hour

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take for Desmotaplasa to treat Acute Ischemic Stroke?. ### Response: 9-hour.


Instruction: How long after ischaemic stroke is desmoteplase given?

Output: 3-9 h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after ischaemic stroke is desmoteplase given?. ### Response: 3-9 h.


Instruction: What is the name of the drug used to treat stroke in patients with occlusion or high grade ste-nosis?

Output: desmoteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used to treat stroke in patients with occlusion or high grade ste-nosis?. ### Response: desmoteplase.


Instruction: What is the name of the double-blind, randomised, placebo-controlled phase 3 trial in patients with occlusion or high-grade ste-nosis in major cerebral arteries?

Output: DIAS-3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the double-blind, randomised, placebo-controlled phase 3 trial in patients with occlusion or high-grade ste-nosis in major cerebral arteries?. ### Response: DIAS-3.


Instruction: What should providers consider for patients with obesity receiving LMWH therapy for treatment of VTE?

Output: using doses based on actual body weight

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should providers consider for patients with obesity receiving LMWH therapy for treatment of VTE?. ### Response: using doses based on actual body weight.


Instruction: What is the conditional recommendation based on?

Output: very low certainty in the evidence abouteffects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the conditional recommendation based on?. ### Response: very low certainty in the evidence abouteffects.


Instruction: What should providers consider using doses based on actual body weight?

Output: LMWH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should providers consider using doses based on actual body weight?. ### Response: LMWH.


Instruction: What should not be monitored in nonobesepatients?

Output: anti –factor Xaconcentrations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not be monitored in nonobesepatients?. ### Response: anti –factor Xaconcentrations.


Instruction: How many studies were included in the most recent systematic review for patients with obesity receiving LMWH for VTE treatment?

Output: 7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were included in the most recent systematic review for patients with obesity receiving LMWH for VTE treatment?. ### Response: 7.


Instruction: What was the total number of studies from 2014 onward?

Output: 7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the total number of studies from 2014 onward?. ### Response: 7.


Instruction: What were included studies in which patients with obesity received LMWH hadanti –factor Xa concentrations monitored?

Output: single-arm cohortstudies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were included studies in which patients with obesity received LMWH hadanti –factor Xa concentrations monitored?. ### Response: single-arm cohortstudies.


Instruction: For the no-monitoringarm, what did we use to determine the risk of major bleeding and VTE events?

Output: a study that reported no anti –factor Xa monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For the no-monitoringarm, what did we use to determine the risk of major bleeding and VTE events?. ### Response: a study that reported no anti –factor Xa monitoring.


Instruction: What did included studies group patients with varying levels of?

Output: indicationsfor LMWH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did included studies group patients with varying levels of?. ### Response: indicationsfor LMWH.


Instruction: What are the most common indications of LMWH?

Output: patients with acute VTE, atrialfibrillation, and acute coronary syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the most common indications of LMWH?. ### Response: patients with acute VTE, atrialfibrillation, and acute coronary syndrome.


Instruction: What are some indications for acute VTE, atrialfibrillation, and acute coronary syndrome?

Output: LMWH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some indications for acute VTE, atrialfibrillation, and acute coronary syndrome?. ### Response: LMWH.


Instruction: What did studies withgrouped indications combine for the outcome of?

Output: percentage of anti –factor Xa concentrations in the therapeuticrange

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did studies withgrouped indications combine for the outcome of?. ### Response: percentage of anti –factor Xa concentrations in the therapeuticrange.


Instruction: What was not used forPE or DVT?

Output: Studies with grouped indications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not used forPE or DVT?. ### Response: Studies with grouped indications.


Instruction: When multiple studies reported the prioritized outcomes, thenumber of events was added across all studies?

Output: umber of events was added across all studies and reportedover the total sample

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When multiple studies reported the prioritized outcomes, thenumber of events was added across all studies?. ### Response: umber of events was added across all studies and reportedover the total sample.


Instruction: What was added across all studies and reported across the total sample?

Output: umber of events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was added across all studies and reported across the total sample?. ### Response: umber of events.


Instruction: What is shown online at http://dbep.gradepro.org/profile/dcf00058-0d87-40b3-9ebc-4dec32706a8b?

Output: The EtD framework

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is shown online at http://dbep.gradepro.org/profile/dcf00058-0d87-40b3-9ebc-4dec32706a8b?. ### Response: The EtD framework.


Instruction: How many observational studies were not included in the evidence profile?

Output: 102 of 227

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many observational studies were not included in the evidence profile?. ### Response: 102 of 227.


Instruction: What percentage of studies measured peak enoxaparin anti –factor Xa concentrations?

Output: 44. 9%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of studies measured peak enoxaparin anti –factor Xa concentrations?. ### Response: 44. 9%.


Instruction: How many of 227 measures were within the therapeutic range defined by the individualstudies following a therapeutic dose?

Output: 102

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many of 227 measures were within the therapeutic range defined by the individualstudies following a therapeutic dose?. ### Response: 102.


Instruction: How many doses of dalteparin anti -factor Xa were taken twice daily?

Output: 200 units per kilogram per day

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many doses of dalteparin anti -factor Xa were taken twice daily?. ### Response: 200 units per kilogram per day.


Instruction: What percentage of patients in the study reported that their doses fell within the definedtherapeutic range?

Output: 71.4%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients in the study reported that their doses fell within the definedtherapeutic range?. ### Response: 71.4%.


Instruction: How many units per milliliter were taken for twice daily dosing?

Output: 1.0 and 2.0

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many units per milliliter were taken for twice daily dosing?. ### Response: 1.0 and 2.0.


Instruction: How many units per milliliter for once-daily dosing?

Output: 1.0 and 2.0

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many units per milliliter for once-daily dosing?. ### Response: 1.0 and 2.0.


Instruction: What was the therapeutic dose of dalteparin assessed with?

Output: peakanti –factor Xa concentration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the therapeutic dose of dalteparin assessed with?. ### Response: peakanti –factor Xa concentration.


Instruction: Why was it difficult to put the results into perspective?

Output: lack of a control group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was it difficult to put the results into perspective?. ### Response: lack of a control group.


Instruction: 7.5% risk range, available generic statins are what?

Output: cost-effective

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: 7.5% risk range, available generic statins are what?. ### Response: cost-effective.


Instruction: What is the challenge among those in a lower ASCVD risk category?

Output: to include those who would benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the challenge among those in a lower ASCVD risk category?. ### Response: to include those who would benefit.


Instruction: What risk group benefits greatly from a clinician-patient risk discussion?

Output: lower ASCVD risk category

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What risk group benefits greatly from a clinician-patient risk discussion?. ### Response: lower ASCVD risk category.


Instruction: Who should assess priorities for health care, perceived ASCVD risk, and prior risk reduction experiences?

Output: Clinicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should assess priorities for health care, perceived ASCVD risk, and prior risk reduction experiences?. ### Response: Clinicians.


Instruction: What should clinicians use best practices for communicating risk to arrive at a shared risk decision?

Output: assess priorities for health care, perceived ASCVD risk, and prior risk reduction experiences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should clinicians use best practices for communicating risk to arrive at a shared risk decision?. ### Response: assess priorities for health care, perceived ASCVD risk, and prior risk reduction experiences.


Instruction: What is probably the best indicator favoring initiation of statin therapy?

Output: The presence of risk-enhancing factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is probably the best indicator favoring initiation of statin therapy?. ### Response: The presence of risk-enhancing factors.


Instruction: A coronary artery calcium score can be useful in who?

Output: select individuals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A coronary artery calcium score can be useful in who?. ### Response: select individuals.


Instruction: What is not recommended routinely?

Output: coronary artery calcium score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended routinely?. ### Response: coronary artery calcium score.


Instruction: Who might benefit from knowing their Coronary Artery Calcium Score Is Zero?

Output: Candidates for Coronary Artery Calcium Measurement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who might benefit from knowing their Coronary Artery Calcium Score Is Zero?. ### Response: Candidates for Coronary Artery Calcium Measurement.


Instruction: Is ZeroCoronary Artery Calcium Measurement Candidates Who Might Benefit from Knowing Their Coronary Artery Calcity Score?

Output: Zero

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Is ZeroCoronary Artery Calcium Measurement Candidates Who Might Benefit from Knowing Their Coronary Artery Calcity Score?. ### Response: Zero.


Instruction: Are older patients concerned about need to reinstitute statin therapy after discontinuation for statin-associated symptoms?

Output: Older patients (men 55–80 y of age; women 60–80 y of age) with low burden of risk factorsS4.3-53 who question whether they would benefit from statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Are older patients concerned about need to reinstitute statin therapy after discontinuation for statin-associated symptoms?. ### Response: Older patients (men 55–80 y of age; women 60–80 y of age) with low burden of risk factorsS4.3-53 who question whether they would benefit from statin therapy.


Instruction: What is the age range of older patients with low burden of risk factors?

Output: 55–80 y of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the age range of older patients with low burden of risk factors?. ### Response: 55–80 y of age.


Instruction: What are middle-aged adults with PCE-calculated 10-year risk of ASCVD 5% to 7.5% with factors that increase?

Output: ASCVD risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are middle-aged adults with PCE-calculated 10-year risk of ASCVD 5% to 7.5% with factors that increase?. ### Response: ASCVD risk.


Instruction: What is the risk of ASCVD 5% to 7.5% with factors that increase their risk?

Output: <7.5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of ASCVD 5% to 7.5% with factors that increase their risk?. ### Response: <7.5%.


Instruction: What are the caveats of withholding statin therapy?

Output: If patient is at intermediate risk and if a risk decision is uncertain and a coronary artery calcium score is obtained

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the caveats of withholding statin therapy?. ### Response: If patient is at intermediate risk and if a risk decision is uncertain and a coronary artery calcium score is obtained.


Instruction: What should be withheld unless higher-risk conditions are present?

Output: statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be withheld unless higher-risk conditions are present?. ### Response: statin therapy.


Instruction: When should reassess coronary artery calcium score?

Output: 5 to 10 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When should reassess coronary artery calcium score?. ### Response: 5 to 10 years.


Instruction: What should be performed in facilities that have current technology and expertise to deliver the lowest radiation possible?

Output: coronary artery calcium scoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be performed in facilities that have current technology and expertise to deliver the lowest radiation possible?. ### Response: coronary artery calcium scoring.


Instruction: What indicates atherosclerotic cardiovascular disease?

Output: ASCVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates atherosclerotic cardiovascular disease?. ### Response: ASCVD.


Instruction: LDL-C, low-density lipoprotein cholesterol, and PCE, pooled cohort equations?

Output: ASCVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: LDL-C, low-density lipoprotein cholesterol, and PCE, pooled cohort equations?. ### Response: ASCVD.


Instruction: How long does it take for T2DMS4.3-61 or 20 years for type 1 diabetes mellitusS4.3-16?

Output: ≥10 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take for T2DMS4.3-61 or 20 years for type 1 diabetes mellitusS4.3-16?. ### Response: ≥10 years.


Instruction: How much albumin/mg albumin does albuminuria have?

Output: ≥30 mcg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much albumin/mg albumin does albuminuria have?. ### Response: ≥30 mcg.


Instruction: How old is a person with type 1 diabetes mellitus?

Output: ≥20 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old is a person with type 1 diabetes mellitus?. ### Response: ≥20 years.


Instruction: What is the average age for a diabetic?

Output: ≥20 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the average age for a diabetic?. ### Response: ≥20 years.


Instruction: How many mcg albumin/mg creatinine do diabetics have?

Output: ≥30

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mcg albumin/mg creatinine do diabetics have?. ### Response: ≥30.


Instruction: What is the name of the molecule that is involved in the response to clopidogrel?

Output: Cytochrome p-450

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the molecule that is involved in the response to clopidogrel?. ### Response: Cytochrome p-450.


Instruction: What are the morphisms of Cytochrome p-450 po ly?

Output: omeprazole, esomeprazole,lansoprazole, pantoprazole, and rabeprazole

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the morphisms of Cytochrome p-450 po ly?. ### Response: omeprazole, esomeprazole,lansoprazole, pantoprazole, and rabeprazole.


Instruction: How many years ago did N Engl J Med publish a 360:354–62.731?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many years ago did N Engl J Med publish a 360:354–62.731?. ### Response: 2009.


Instruction: What is GRAVITAS?

Output: Impact on Thrombosis and Safety

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is GRAVITAS?. ### Response: Impact on Thrombosis and Safety.


Instruction: What is the effect of CYP2C19 genotype on outcomes?

Output: clopidogrel treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of CYP2C19 genotype on outcomes?. ### Response: clopidogrel treatment.


Instruction: What does CYP2C19 genotype have on outcomes of clopidogrel treatment?

Output: Effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CYP2C19 genotype have on outcomes of clopidogrel treatment?. ### Response: Effects.


Instruction: What is omeprazol associated with?

Output: aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is omeprazol associated with?. ### Response: aspirin.


Instruction: When did ThrombHaemost issue a 4:2508–9.735.

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did ThrombHaemost issue a 4:2508–9.735.. ### Response: 2006.


Instruction: What is omeprazole associated with in aspiri n?

Output: inhibiting drugs omeprazole, esomeprazole,lansoprazole, pantoprazole, and rabeprazole on human cytochromeP450 activities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is omeprazole associated with in aspiri n?. ### Response: inhibiting drugs omeprazole, esomeprazole,lansoprazole, pantoprazole, and rabeprazole on human cytochromeP450 activities.


Instruction: What is the name of the double-blind, ran-domized study?

Output: OCLA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the double-blind, ran-domized study?. ### Response: OCLA.


Instruction: What is the name of the population-based study of the drug interaction between proton pump inhibitors and clopid ogrel?

Output: CMAJ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the population-based study of the drug interaction between proton pump inhibitors and clopid ogrel?. ### Response: CMAJ.


Instruction: What is a risk of adverse outcomes associated with concomitant use of proton pumps in-hibitors following acute coronary syndrome?

Output: inhibitoryeffects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk of adverse outcomes associated with concomitant use of proton pumps in-hibitors following acute coronary syndrome?. ### Response: inhibitoryeffects.


Instruction: What is clopidogrel with or withoutomeprazole used for in coronary artery disease?

Output: percutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is clopidogrel with or withoutomeprazole used for in coronary artery disease?. ### Response: percutaneous coronary intervention.


Instruction: What is the name of the study that evaluated the efficacy of two drugs?

Output: Proton Pump Inhibitors And Clopidogrel Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated the efficacy of two drugs?. ### Response: Proton Pump Inhibitors And Clopidogrel Association.


Instruction: What is omeprazole used for in coronary artery disease?

Output: inhibiting drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is omeprazole used for in coronary artery disease?. ### Response: inhibiting drugs.


Instruction: What is the name of the drug that inhibits human cytochromeP450?

Output: omeprazole

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug that inhibits human cytochromeP450?. ### Response: omeprazole.


Instruction: In what year did Drug Metab Dispos publish?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did Drug Metab Dispos publish?. ### Response: 2004.


Instruction: What is the name of the randomized study that compares omeprazole and pantoprazole on clopidogrel maintenance?

Output: PACA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized study that compares omeprazole and pantoprazole on clopidogrel maintenance?. ### Response: PACA.


Instruction: What does PACA stand for?

Output: Proton Pump Inhibitors And Clopidogrel Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does PACA stand for?. ### Response: Proton Pump Inhibitors And Clopidogrel Association.


Instruction: What is the name of the prospective randomized study?

Output: OCLA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective randomized study?. ### Response: OCLA.


Instruction: When was the PACA study published?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the PACA study published?. ### Response: 2009.


Instruction: What is the time dependence of plateletinhibition after a 60–mg loading dose of clopidogrel in a large, unse-lected cohort of candidates for percutaneous coronary intervention?

Output: atime

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the time dependence of plateletinhibition after a 60–mg loading dose of clopidogrel in a large, unse-lected cohort of candidates for percutaneous coronary intervention?. ### Response: atime.


Instruction: Circulation. 2005;111:2560–4.

Output: Hochholzer W, Trenk D, Frundi D, et al. Time dependence of plateletinhibition after a 60–mg loading dose of clopidogrel in a large, unse-lected cohort of candidates for percutaneous coronary intervention.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation. 2005;111:2560–4.. ### Response: Hochholzer W, Trenk D, Frundi D, et al. Time dependence of plateletinhibition after a 60–mg loading dose of clopidogrel in a large, unse-lected cohort of candidates for percutaneous coronary intervention..


Instruction: What percentage of statin treatment groups had major cardiovascular events in 3.8 years?

Output: 8.5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of statin treatment groups had major cardiovascular events in 3.8 years?. ### Response: 8.5%.


Instruction: Strong general evidence indicates that the benefit from statin therapy is related to both global risk and intensity of treatment?

Output: S4.3-3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Strong general evidence indicates that the benefit from statin therapy is related to both global risk and intensity of treatment?. ### Response: S4.3-3.


Instruction: High-intensity statin therapy has been carried out in cohorts of whom?

Output: >75 years of age with diabetes mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: High-intensity statin therapy has been carried out in cohorts of whom?. ### Response: >75 years of age with diabetes mellitus.


Instruction: Patients with diabetes mellitus have a higher trajectory of what?

Output: lifetime risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with diabetes mellitus have a higher trajectory of what?. ### Response: lifetime risk.


Instruction: High-intensity statin therapy is preferred in patients with diabetes mellitus as they age or develop what?

Output: risk modifiers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: High-intensity statin therapy is preferred in patients with diabetes mellitus as they age or develop what?. ### Response: risk modifiers.


Instruction: ASCVD risk increases incrementally with what type of diabetes?

Output: age in diabetes mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ASCVD risk increases incrementally with what type of diabetes?. ### Response: age in diabetes mellitus.


Instruction: In one long-term cohort study, incident rates of MI averaged what per year?

Output: 25.6 per 1000 person-years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In one long-term cohort study, incident rates of MI averaged what per year?. ### Response: 25.6 per 1000 person-years.


Instruction: How many incidents of MI were there per 1000 person-years?

Output: 25.6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many incidents of MI were there per 1000 person-years?. ### Response: 25.6.


Instruction: What was the 10-year fatal CVD risk in those >75 years old?

Output: 70% in men and 40% in women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 10-year fatal CVD risk in those >75 years old?. ### Response: 70% in men and 40% in women.


Instruction: What percentage of women are statin trials?

Output: 40%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of women are statin trials?. ### Response: 40%.


Instruction: What is JUPITER?

Output: Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is JUPITER?. ### Response: Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin.


Instruction: Which trials showed similar benefits in ASCVD?

Output: JUPITER (Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin) and HOPE-3 (Heart Outcomes Prevention Evaluation)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which trials showed similar benefits in ASCVD?. ### Response: JUPITER (Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin) and HOPE-3 (Heart Outcomes Prevention Evaluation).


Instruction: What is the acronym for Heart Outcomes Prevention Evaluation?

Output: HOPE-3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Heart Outcomes Prevention Evaluation?. ### Response: HOPE-3.


Instruction: What type of patients were included in the study?

Output: few patients with diabetes mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of patients were included in the study?. ### Response: few patients with diabetes mellitus.


Instruction: How did the study support the continued use of statin therapy?

Output: it does support the continuation of moderate- or high-intensity statin therapy for primary prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did the study support the continued use of statin therapy?. ### Response: it does support the continuation of moderate- or high-intensity statin therapy for primary prevention.


Instruction: What percentage of the population with diabetes mellitus are treated for primary prevention?

Output: 21%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the population with diabetes mellitus are treated for primary prevention?. ### Response: 21%.


Instruction: What may be off-set by limited life span or increased susceptibility to adverse events?

Output: the benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be off-set by limited life span or increased susceptibility to adverse events?. ### Response: the benefit.


Instruction: What type of risk enhancers are independent of other risk factors in diabetes Mellitus?

Output: Diabetes-Specific

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of risk enhancers are independent of other risk factors in diabetes Mellitus?. ### Response: Diabetes-Specific.


Instruction: How long does it take for type 2 diabetes mellitus to develop albuminuria?

Output: ≥10 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take for type 2 diabetes mellitus to develop albuminuria?. ### Response: ≥10 years.


Instruction: What is type 1 diabetes mellitus?

Output: S4.3-6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is type 1 diabetes mellitus?. ### Response: S4.3-6.


Instruction: What is the estimated glomerular filtration rate?

Output: eGFR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the estimated glomerular filtration rate?. ### Response: eGFR.


Instruction: What is the unreliabil-ity of serum creatinine to assess age-related renal dysfunc-tion?

Output: drug toxicity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the unreliabil-ity of serum creatinine to assess age-related renal dysfunc-tion?. ### Response: drug toxicity.


Instruction: Bleeding in older patients with NSTE-ACS is multifactorial, resulting in what?

Output: nar -rower therapeutic windows

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Bleeding in older patients with NSTE-ACS is multifactorial, resulting in what?. ### Response: nar -rower therapeutic windows.


Instruction: How do Unstable Angina Patients Suppress Adverse Outcomes?

Output: **Those ≥75 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do Unstable Angina Patients Suppress Adverse Outcomes?. ### Response: **Those ≥75 years of age.


Instruction: How old are those 75 years of age?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old are those 75 years of age?. ### Response: ≥.


Instruction: When was this article downloaded?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this article downloaded?. ### Response: April 28, 2023.


Instruction: Dr You, Schulman, and Spencer are from what department at McMaster University?

Output: Department   of Medicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Dr You, Schulman, and Spencer are from what department at McMaster University?. ### Response: Department   of Medicine.


Instruction: Who is from the Department of Medicine at Harvard Medical School?

Output: Dr Singer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is from the Department of Medicine at Harvard Medical School?. ### Response: Dr Singer.


Instruction: What department is from Dr You?

Output: Department of Clinical Epidemi-ology and Biostatistics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What department is from Dr You?. ### Response: Department of Clinical Epidemi-ology and Biostatistics.


Instruction: Who is in the School of Pharmacy?

Output: Dr Howard

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is in the School of Pharmacy?. ### Response: Dr Howard.


Instruction: Where is the University of Kansas Medical Center?

Output: Kansas City, KS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the University of Kansas Medical Center?. ### Response: Kansas City, KS.


Instruction: What is the Department of Clinical Medi-cine?

Output: Dr Eckman

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Department of Clinical Medi-cine?. ### Response: Dr Eckman.


Instruction: Where is the Birmingham Hospital located?

Output: Birmingham, England

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the Birmingham Hospital located?. ### Response: Birmingham, England.


Instruction: Who is the Director of the Department of Clinical Medi-cine?

Output: Dr Eckman

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Director of the Department of Clinical Medi-cine?. ### Response: Dr Eckman.


Instruction: What is the name of the Division of General Internal Medicine and Center for Clinical Effectiveness at the University of Cincinnati?

Output: Department of Clinical Medi-cine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Division of General Internal Medicine and Center for Clinical Effectiveness at the University of Cincinnati?. ### Response: Department of Clinical Medi-cine.


Instruction: Who is the Director of the Comprehensive Clinical Research Unit at Kaiser Permanente Northern California?

Output: Dr Go

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Director of the Comprehensive Clinical Research Unit at Kaiser Permanente Northern California?. ### Response: Dr Go.


Instruction: Where is the Head of Non-invasive Cardiac Imaging at Beth Israel Deaconess Medical Center?

Output: Boston, MA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the Head of Non-invasive Cardiac Imaging at Beth Israel Deaconess Medical Center?. ### Response: Boston, MA.


Instruction: What is Dr Manning's specialty?

Output: Cardiac Imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Dr Manning's specialty?. ### Response: Cardiac Imaging.


Instruction: Where is Beth Israel Deaconess Medical Center?

Output: Boston, MA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Beth Israel Deaconess Medical Center?. ### Response: Boston, MA.


Instruction: What is the specialty of Dr Halperin?

Output: Cardiovas-cular Institute

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the specialty of Dr Halperin?. ### Response: Cardiovas-cular Institute.


Instruction: In what city is the Cardiovas-cular Institute located?

Output: New York, NY

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what city is the Cardiovas-cular Institute located?. ### Response: New York, NY.


Instruction: Who provided support for the Chest Physicians Evidence-Based Clinical Practice Guidelines?

Output: National Heart, Lung, and Blood Institute [R13 HL104758] and Bayer Schering Pharma AG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who provided support for the Chest Physicians Evidence-Based Clinical Practice Guidelines?. ### Response: National Heart, Lung, and Blood Institute [R13 HL104758] and Bayer Schering Pharma AG.


Instruction: Who provided educational grants?

Output: Bristol-Myers Squibb; Pﬁ  zer, Inc; Canyon Pharmaceuticals; and sanoﬁ  -aventis US

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who provided educational grants?. ### Response: Bristol-Myers Squibb; Pﬁ  zer, Inc; Canyon Pharmaceuticals; and sanoﬁ  -aventis US.


Instruction: What company provided educational grant support?

Output: Bristol-Myers Squibb

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What company provided educational grant support?. ### Response: Bristol-Myers Squibb.


Instruction: Where did the National Heart, Lung, and Blood Institute receive funding?

Output: The Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines received support from the National Heart, Lung, and Blood Institute [R13 HL104758] and Bayer Schering Pharma AG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where did the National Heart, Lung, and Blood Institute receive funding?. ### Response: The Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines received support from the National Heart, Lung, and Blood Institute [R13 HL104758] and Bayer Schering Pharma AG.


Instruction: What is the name of Inc.?

Output: Pﬁ  zer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of Inc.?. ### Response: Pﬁ  zer.


Instruction: What are the names of Canyon Pharmaceuticals and sanofi-aventis US?

Output: Pﬁ  zer, Inc;

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of Canyon Pharmaceuticals and sanofi-aventis US?. ### Response: Pﬁ  zer, Inc;.


Instruction: What should be sought for any medical condition?

Output: professional medical care and physician advice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be sought for any medical condition?. ### Response: professional medical care and physician advice.


Instruction: What can be accessed at http://chestjournal.chestpubs.org/content/141/2_suppl/1S?

Output: The complete disclaimer for this guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be accessed at http://chestjournal.chestpubs.org/content/141/2_suppl/1S?. ### Response: The complete disclaimer for this guideline.


Instruction: What year did the American College of Chest Physicians publish this article?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did the American College of Chest Physicians publish this article?. ### Response: 2012.


Instruction: What is the name of the organization that published this article in 2012?

Output: American College of Chest Physicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that published this article in 2012?. ### Response: American College of Chest Physicians.


Instruction: Where can you find a copy of this article from?

Output: American College of Chest Physicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find a copy of this article from?. ### Response: American College of Chest Physicians.


Instruction: What type of text is used throughout the summary of recommenda-tions?

Output: Shaded

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of text is used throughout the summary of recommenda-tions?. ### Response: Shaded.


Instruction: What should patients who are unable to exercise have?

Output: a pharmacological stress test with imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients who are unable to exercise have?. ### Response: a pharmacological stress test with imaging.


Instruction: What should low- and intermediate-risk patients with NSTE-ACS have with imaging?

Output: pharmacological stress test

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should low- and intermediate-risk patients with NSTE-ACS have with imaging?. ### Response: pharmacological stress test.


Instruction: What can low- and intermediate-risk patients with NSTE-ACS undergo?

Output: symptom-lim-ited stress testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can low- and intermediate-risk patients with NSTE-ACS undergo?. ### Response: symptom-lim-ited stress testing.


Instruction: How long can patients with UA be symptom-lim-ited stress testing?

Output: 12 to 24 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long can patients with UA be symptom-lim-ited stress testing?. ### Response: 12 to 24 hours.


Instruction: What is the optimal testing strategy in women?

Output: less well defined

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the optimal testing strategy in women?. ### Response: less well defined.


Instruction: What is the optimal testing strategy in women less well defined than in men?

Output: 349

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the optimal testing strategy in women less well defined than in men?. ### Response: 349.


Instruction: What provides detailed structural information for assessment of prognosis and appropriate management?

Output: coronary angiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What provides detailed structural information for assessment of prognosis and appropriate management?. ### Response: coronary angiography.


Instruction: When combined with LV angiography, what provides an assessment of global and global?

Output: coronary angiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When combined with LV angiography, what provides an assessment of global and global?. ### Response: coronary angiography.


Instruction: What provides an assessment of global and regional LV function?

Output: LV angi-ography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What provides an assessment of global and regional LV function?. ### Response: LV angi-ography.


Instruction: What is usually indicated in patients with NSTE-ACS who have recurrent symptoms or ischemia?

Output: Coronary angiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is usually indicated in patients with NSTE-ACS who have recurrent symptoms or ischemia?. ### Response: Coronary angiography.


Instruction: What is HF?

Output: serious ventricular arrhythmias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is HF?. ### Response: serious ventricular arrhythmias.


Instruction: What is the Duke treadmill score 11?

Output: −11

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Duke treadmill score 11?. ### Response: −11.


Instruction: How are patients with NSTE-ACS diagnosed?

Output: at high risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are patients with NSTE-ACS diagnosed?. ### Response: at high risk.


Instruction: What should patients with NSTE-ACS who have had previous PCI or CABG be considered for?

Output: early coronary angiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients with NSTE-ACS who have had previous PCI or CABG be considered for?. ### Response: early coronary angiography.


Instruction: What should be tempered by patient characteristics and preferences?

Output: The general indications for coronary angiography and revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be tempered by patient characteristics and preferences?. ### Response: The general indications for coronary angiography and revascularization.


Instruction: What should be tempered by individual patient characteristics and preferences?

Output: The general indications for coronary angiography and revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be tempered by individual patient characteristics and preferences?. ### Response: The general indications for coronary angiography and revascularization.