Instruction: What is the morbidity rate of postoperative myocardial infarction, stroke, pulmonary edema, intubation >24 hours, and major arrhythmias than case-matched controls without AR?

Output: higher mor -bidity rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the morbidity rate of postoperative myocardial infarction, stroke, pulmonary edema, intubation >24 hours, and major arrhythmias than case-matched controls without AR?. ### Response: higher mor -bidity rate.


Instruction: What is elevated serum creatinine >2 mg/dL?

Output: Decreased LV systolic function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is elevated serum creatinine >2 mg/dL?. ### Response: Decreased LV systolic function.


Instruction: What are the 2018 Cholesterol Clinical Practice Guidelines8?

Output: LIMITATIONS AND KNOWLEDGE GAPS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the 2018 Cholesterol Clinical Practice Guidelines8?. ### Response: LIMITATIONS AND KNOWLEDGE GAPS.


Instruction: What are ACC/AHA guidelines based largely on?

Output: the outcomes of RCTs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are ACC/AHA guidelines based largely on?. ### Response: the outcomes of RCTs.


Instruction: What do RCTs of cholesterol-lowering thera-pies have established?

Output: greater reductions of LDL-C are accompanied by greater reductions in risk of ASCVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do RCTs of cholesterol-lowering thera-pies have established?. ### Response: greater reductions of LDL-C are accompanied by greater reductions in risk of ASCVD.


Instruction: What are greater reductions of LDL-C accompanied by?

Output: greater reductions in risk of ASCVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are greater reductions of LDL-C accompanied by?. ### Response: greater reductions in risk of ASCVD.


Instruction: Robust RCT exist for both what?

Output: primary and secondary preven-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Robust RCT exist for both what?. ### Response: primary and secondary preven-tion.


Instruction: Most of the data from RCT have been obtained with statin therapy?

Output: Robust RCTs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Most of the data from RCT have been obtained with statin therapy?. ### Response: Robust RCTs.


Instruction: How many RCTs have been obtained with statin therapy?

Output: Most

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs have been obtained with statin therapy?. ### Response: Most.


Instruction: What have nonstatins been ob-tained with as add-on drugs?

Output: Important limited data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have nonstatins been ob-tained with as add-on drugs?. ### Response: Important limited data.


Instruction: What are the indications for adding PCSK9 inhibitors to maximal statins?

Output: secondary prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the indications for adding PCSK9 inhibitors to maximal statins?. ### Response: secondary prevention.


Instruction: What is a lower limit for LDL-C attainment worth?

Output: neither the risks nor the cost of additional therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a lower limit for LDL-C attainment worth?. ### Response: neither the risks nor the cost of additional therapy.


Instruction: What are the indications for adding PCSK9 inhibitors to maximal statin therapy?

Output: secondary prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the indications for adding PCSK9 inhibitors to maximal statin therapy?. ### Response: secondary prevention.


Instruction: What is an effective and safe substitute for high-intensity statins?

Output: PCSK9 inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an effective and safe substitute for high-intensity statins?. ### Response: PCSK9 inhibitors.


Instruction: What is the incremental risk reduction imparted by high-intensity statins compared to?

Output: moderate-intensity statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the incremental risk reduction imparted by high-intensity statins compared to?. ### Response: moderate-intensity statins.


Instruction: How old are adults 45 to 75 years of age?

Output: (>75 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old are adults 45 to 75 years of age?. ### Response: (>75 years of age.


Instruction: What is a net benefit of statin therapy in older patients?

Output: efficacious and safe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a net benefit of statin therapy in older patients?. ### Response: efficacious and safe.


Instruction: What is the risk reduction imparted by moderate-intensity statins plus ezetimibe?

Output: incremen-tal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk reduction imparted by moderate-intensity statins plus ezetimibe?. ### Response: incremen-tal.


Instruction: What is a net benefit of statin therapy in this age group?

Output: Is statin therapy efficacious and safe in older patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a net benefit of statin therapy in this age group?. ### Response: Is statin therapy efficacious and safe in older patients.


Instruction: In patients with severe hypercholesterolemia, what are the efficacy of PCSK9 inhibitors?

Output: net benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with severe hypercholesterolemia, what are the efficacy of PCSK9 inhibitors?. ### Response: net benefit.


Instruction: What are some risk-enhancing factors?

Output: chronic inflammatory dis-ease, CKD, metabolic syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some risk-enhancing factors?. ### Response: chronic inflammatory dis-ease, CKD, metabolic syndrome.


Instruction: What is highly de-pendent on risk assessment?

Output: the appropriate selection of pa-tients for cholesterol-lowering drug therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is highly de-pendent on risk assessment?. ### Response: the appropriate selection of pa-tients for cholesterol-lowering drug therapy.


Instruction: Figure 3. Cost-effectiveness analysis for PCSK9 inhibitors.

Output: Conceptual relationship between the clinical effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Figure 3. Cost-effectiveness analysis for PCSK9 inhibitors.. ### Response: Conceptual relationship between the clinical effectiveness.


Instruction: What is the cost-effectiveness analysis for PCSK9 inhibitors?

Output: Figure 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cost-effectiveness analysis for PCSK9 inhibitors?. ### Response: Figure 3.


Instruction: What does the top curve indicate?

Output: the relationship at full U.S list price

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the top curve indicate?. ### Response: the relationship at full U.S list price.


Instruction: What axis indicates the relationship at full U.S. list price of PCSK9 inhibi-tion?

Output: top curve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What axis indicates the relationship at full U.S. list price of PCSK9 inhibi-tion?. ### Response: top curve.


Instruction: Meschia et al Guidelines for the Primary Prevention of Stroke 3771in all-cause mortality per 1-mmol/L LDL cholesterol reduction?

Output: 91; 95% CI, 0.82–1.01; P =0.02) and a 13% reduction in vascular death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Meschia et al Guidelines for the Primary Prevention of Stroke 3771in all-cause mortality per 1-mmol/L LDL cholesterol reduction?. ### Response: 91; 95% CI, 0.82–1.01; P =0.02) and a 13% reduction in vascular death.


Instruction: A 13% reduction in vascular death?

Output: Meschia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A 13% reduction in vascular death?. ### Response: Meschia.


Instruction: What was the RR of gemfibrozil?

Output: 0.79

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the RR of gemfibrozil?. ### Response: 0.79.


Instruction: What is the 95% confidence interval for stroke?

Output: 0.67–0.93

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 95% confidence interval for stroke?. ### Response: 0.67–0.93.


Instruction: Where was the subgroup analysis done?

Output: Department of Veterans Affairs High-Density Lipoprotein Intervention Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where was the subgroup analysis done?. ### Response: Department of Veterans Affairs High-Density Lipoprotein Intervention Trial.


Instruction: How long did subjects receive gemfibrozil or placebo?

Output: 5.1 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did subjects receive gemfibrozil or placebo?. ### Response: 5.1 years.


Instruction: What was the risk for major cardiovascular events in subjects with known or newly diagnosed heart disease?

Output: higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk for major cardiovascular events in subjects with known or newly diagnosed heart disease?. ### Response: higher.


Instruction: What was the HR of newly diagnosed diabetes mellitus?

Output: 1.72

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the HR of newly diagnosed diabetes mellitus?. ### Response: 1.72.


Instruction: What did Gemfibrozil treatment not affect the risk of?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Gemfibrozil treatment not affect the risk of?. ### Response: stroke.


Instruction: How much reduction in stroke was treated in those with diabe-tes melliitus after treatment?

Output: 40%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much reduction in stroke was treated in those with diabe-tes melliitus after treatment?. ### Response: 40%.


Instruction: Which treatment was associated with a 40% reduction of stroke in those without diabetes?

Output: Gemfibrozil

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which treatment was associated with a 40% reduction of stroke in those without diabetes?. ### Response: Gemfibrozil.


Instruction: What is the HR of diabetes mellitus?

Output: 1.72

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the HR of diabetes mellitus?. ### Response: 1.72.


Instruction: What was the 95% CI of fenofibrate?

Output: 0.67–0.93

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 95% CI of fenofibrate?. ### Response: 0.67–0.93.


Instruction: How many subjects were in the FIELD study?

Output: 9795

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many subjects were in the FIELD study?. ### Response: 9795.


Instruction: What was taken at study entry?

Output: placebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was taken at study entry?. ### Response: placebo.


Instruction: How many people were included in the study population?

Output: 2131

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were included in the study population?. ### Response: 2131.


Instruction: What percentage of patients on placebo had a coronary event over 5 years?

Output: 5.9%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients on placebo had a coronary event over 5 years?. ### Response: 5.9%.


Instruction: What was a 24% reduction in nonfatal MI?

Output: RR, 0.76

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a 24% reduction in nonfatal MI?. ### Response: RR, 0.76.


Instruction: What was no effect on stroke with fenofibrate?

Output: primary outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was no effect on stroke with fenofibrate?. ### Response: primary outcome.


Instruction: How many patients with type 2 diabetes were randomized in the ACCORD trial?

Output: 5518

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with type 2 diabetes were randomized in the ACCORD trial?. ### Response: 5518.


Instruction: How many patients were randomized to fenofibrate or placebo?

Output: 5518

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were randomized to fenofibrate or placebo?. ### Response: 5518.


Instruction: What was the primary outcome of the ACCORD trial?

Output: first occurrence of nonfatal MI, nonfatal stroke, or death from cardiovascular causes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary outcome of the ACCORD trial?. ### Response: first occurrence of nonfatal MI, nonfatal stroke, or death from cardiovascular causes.


Instruction: How many people had type 2 diabetes mellitus treated with simvastatin?

Output: 5518

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people had type 2 diabetes mellitus treated with simvastatin?. ### Response: 5518.


Instruction: How many patients had a recent meta-analysis examining the effects of fibrates on stroke in 37 791 patients?

Output: 320

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had a recent meta-analysis examining the effects of fibrates on stroke in 37 791 patients?. ### Response: 320.


Instruction: How many patients had diabetes mellitus?

Output: 5518

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had diabetes mellitus?. ### Response: 5518.


Instruction: What was not associated with a significant reduction on the risk of stroke?

Output: fibrate therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not associated with a significant reduction on the risk of stroke?. ### Response: fibrate therapy.


Instruction: A subgroup analysis suggested that fibrate therapy reduced fatal stroke in patients with what condition?

Output: diabe-tes mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A subgroup analysis suggested that fibrate therapy reduced fatal stroke in patients with what condition?. ### Response: diabe-tes mellitus.


Instruction: What is the RR of a stroke in patients with diabetes mellitus, CVD, or stroke?

Output: 0.79

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the RR of a stroke in patients with diabetes mellitus, CVD, or stroke?. ### Response: 0.79.


Instruction: What is a benefit of aspirin in the primary prevention of cardiovascu-lar events?

Output: 40% reduction in stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a benefit of aspirin in the primary prevention of cardiovascu-lar events?. ### Response: 40% reduction in stroke.


Instruction: What is low risk patient group that is a diagnosis of exclusion?

Output: Lone ”atrial ﬂutter (without any recognizableunderlying disease), like lone AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is low risk patient group that is a diagnosis of exclusion?. ### Response: Lone ”atrial ﬂutter (without any recognizableunderlying disease), like lone AF.


Instruction: What is lone ”atrial flutter?

Output: without any recognizableunderlying disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is lone ”atrial flutter?. ### Response: without any recognizableunderlying disease.


Instruction: What is assumed to be the same?

Output: the risk of stroke and thromboembolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is assumed to be the same?. ### Response: the risk of stroke and thromboembolism.


Instruction: What are the same risk strati ficationapproaches?

Output: the risk of stroke and thromboembolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the same risk strati ficationapproaches?. ### Response: the risk of stroke and thromboembolism.


Instruction: What is an independent risk factor for stroke?

Output: AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an independent risk factor for stroke?. ### Response: AF.


Instruction: What is not all patients with AF have equal stroke risk?

Output: Although AF is anindependent risk factor for stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not all patients with AF have equal stroke risk?. ### Response: Although AF is anindependent risk factor for stroke.


Instruction: How have risk prediction tools been developed?

Output: based on therisk factors most strongly and consistently associatedwith stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How have risk prediction tools been developed?. ### Response: based on therisk factors most strongly and consistently associatedwith stroke.


Instruction: What are predictionor strati fication tools based on?

Output: therisk factors most strongly and consistently associatedwith stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are predictionor strati fication tools based on?. ### Response: therisk factors most strongly and consistently associatedwith stroke.


Instruction: What are the most strongly and consistently associated with stroke?

Output: therisk factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the most strongly and consistently associated with stroke?. ### Response: therisk factors.


Instruction: How many studies were positive for TIA?

Output: 15 of 16

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were positive for TIA?. ### Response: 15 of 16.


Instruction: How many studies were positive forsex?

Output: 8 of 22

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were positive forsex?. ### Response: 8 of 22.


Instruction: What was the RR of 20 studies positive?

Output: 1.85

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the RR of 20 studies positive?. ### Response: 1.85.


Instruction: How manystudies were negative for vascular disease?

Output: 6 of 17

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How manystudies were negative for vascular disease?. ### Response: 6 of 17.


Instruction: How many studies were positive for nonparoxysmal AF?

Output: 15 of 16

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were positive for nonparoxysmal AF?. ### Response: 15 of 16.


Instruction: How many of the studies positive for vascular disease had a RR of 2.61?

Output: 6 of 17

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many of the studies positive for vascular disease had a RR of 2.61?. ### Response: 6 of 17.


Instruction: What was the RR score for HF?

Output: 1.85

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the RR score for HF?. ### Response: 1.85.


Instruction: Which type of AF is associated with a highly significant increase inthromboembolism?

Output: Nonparoxysmal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which type of AF is associated with a highly significant increase inthromboembolism?. ### Response: Nonparoxysmal.


Instruction: HF is an independent predictor of stroke/thromboembolism, mortality, and what other clinical outcome in individuals with AF?

Output: worseprognosis than sinus rhythm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: HF is an independent predictor of stroke/thromboembolism, mortality, and what other clinical outcome in individuals with AF?. ### Response: worseprognosis than sinus rhythm.


Instruction: HF has been incorporated in tools for risk prediction of incident AF.

Output: predictor ofdevelopment of AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: HF has been incorporated in tools for risk prediction of incident AF.. ### Response: predictor ofdevelopment of AF.


Instruction: What is higher in HF patients with reduced ejectionfraction compared with HF with preserved?

Output: All-cause mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is higher in HF patients with reduced ejectionfraction compared with HF with preserved?. ### Response: All-cause mortality.


Instruction: What is not significantly different between stroke risk and hospitalization?

Output: stroke risk (RR, 0.85; 95% CI, 0.70-1.03;P¼.094) and HF hospitalization (RR, 1.21; 95% CI,0.96-1.53; P¼.115) are not signi ﬁcantly different

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not significantly different between stroke risk and hospitalization?. ### Response: stroke risk (RR, 0.85; 95% CI, 0.70-1.03;P¼.094) and HF hospitalization (RR, 1.21; 95% CI,0.96-1.53; P¼.115) are not signi ﬁcantly different.


Instruction: What is an independent predictor of risk of stroke/thromboembolism?

Output: HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an independent predictor of risk of stroke/thromboembolism?. ### Response: HF.


Instruction: What is the RR of AF patients with an estimatedglomerular filtration rate 60 mL/min?

Output: 1.62

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the RR of AF patients with an estimatedglomerular filtration rate 60 mL/min?. ### Response: 1.62.


Instruction: What is the risk of bleeding in individuals with renal replacement therapy?

Output: increased

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of bleeding in individuals with renal replacement therapy?. ### Response: increased.


Instruction: What is a risk of a decrease in renal function in individuals requiring renal replacementtherapy?

Output: higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk of a decrease in renal function in individuals requiring renal replacementtherapy?. ### Response: higher.


Instruction: How much increase in annual increase is there for a 10 mL/min decrease of renal function?

Output: 0.41%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much increase in annual increase is there for a 10 mL/min decrease of renal function?. ### Response: 0.41%.


Instruction: What association consulted on the discontinuation of dual antiplatelet therapy in patients with coronary artery stents?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What association consulted on the discontinuation of dual antiplatelet therapy in patients with coronary artery stents?. ### Response: American Heart Association.


Instruction: Who represented the American College of Physicians in the advisory?

Output: American Heart Association, American College of Cardiology, Society for Cardiovascular Angiography and Interventions, American College of Surgeons, and American Dental Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who represented the American College of Physicians in the advisory?. ### Response: American Heart Association, American College of Cardiology, Society for Cardiovascular Angiography and Interventions, American College of Surgeons, and American Dental Association.


Instruction: What year did J Am Coll Cardiol.49:734–9?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did J Am Coll Cardiol.49:734–9?. ### Response: 2007.


Instruction: What is the American College of Chest Physicians' Tobacco dependence treatment toolkit?

Output: chestnet.org

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the American College of Chest Physicians' Tobacco dependence treatment toolkit?. ### Response: chestnet.org.


Instruction: When was the tobacco dependency treatment tool kit available?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the tobacco dependency treatment tool kit available?. ### Response: 2014.


Instruction: What is a science advisory for high blood pressure control?

Output: American Heart Association, the American College of Cardiology, and the Centers for Disease Control and Prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a science advisory for high blood pressure control?. ### Response: American Heart Association, the American College of Cardiology, and the Centers for Disease Control and Prevention.


Instruction: What is the name of the science advisory from the American Heart Association, the American College of Cardiology, and the Centers for Disease Control and Prevention?

Output: Council on Clinical Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the science advisory from the American Heart Association, the American College of Cardiology, and the Centers for Disease Control and Prevention?. ### Response: Council on Clinical Cardiology.


Instruction: What does the American Diabetes Association Standards of Medical Care in Diabetes do?

Output: Position statement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the American Diabetes Association Standards of Medical Care in Diabetes do?. ### Response: Position statement.


Instruction: What is the name of the ESC Council on Cardiovascular Nursing and Allied Professions?

Output: CCNAP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the ESC Council on Cardiovascular Nursing and Allied Professions?. ### Response: CCNAP.


Instruction: What does CCNAP stand for?

Output: Cardiovascular Nursing and Allied Professions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CCNAP stand for?. ### Response: Cardiovascular Nursing and Allied Professions.


Instruction: What is the acronym for the Allied Professions (CCNAP). Circulation. 2013;128:2075–96. 509. Lichtman JH, Bigger JT Jr., Blumenthal JA, et al. Depression and coronary heart disease: recommendations for screening, referral, and what else?

Output: ESC Council on Cardiovascular Nursing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the Allied Professions (CCNAP). Circulation. 2013;128:2075–96. 509. Lichtman JH, Bigger JT Jr., Blumenthal JA, et al. Depression and coronary heart disease: recommendations for screening, referral, and what else?. ### Response: ESC Council on Cardiovascular Nursing.


Instruction: What is the acronym for the National Quality Forum?

Output: NQF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the National Quality Forum?. ### Response: NQF.


Instruction: What are the acronyms for the Council on Clinical Cardiology, Council on Epidemiology and Prevention, and Interdisciplinary Council on Quality of Care?

Output: Council on Clinical Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the acronyms for the Council on Clinical Cardiology, Council on Epidemiology and Prevention, and Interdisciplinary Council on Quality of Care?. ### Response: Council on Clinical Cardiology.


Instruction: When was a con-sensus report released?

Output: April 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was a con-sensus report released?. ### Response: April 2009.


Instruction: Who developed a best practices model for discharge counseling for patients with heart failure or myocardial infarction?

Output: members of the American College of Clinical Pharmacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who developed a best practices model for discharge counseling for patients with heart failure or myocardial infarction?. ### Response: members of the American College of Clinical Pharmacy.


Instruction: What is the name of the American College of Clinical Pharmacy's Cardiology Practice and Research Network based on?

Output: Hospital to Home (H2H) Initiative

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the American College of Clinical Pharmacy's Cardiology Practice and Research Network based on?. ### Response: Hospital to Home (H2H) Initiative.


Instruction: What is H2H?

Output: Hospital to Home

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is H2H?. ### Response: Hospital to Home.


Instruction: When was effective communication and care coordination published?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was effective communication and care coordination published?. ### Response: 2013.


Instruction: Where was the Institute of Medicine's "Cardivascular disability: updating the Social Security listings" published in 2010?

Output: Washington, DC: The National Academies Press

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where was the Institute of Medicine's "Cardivascular disability: updating the Social Security listings" published in 2010?. ### Response: Washington, DC: The National Academies Press.


Instruction: Who published Acute coronary care in the elderly, part I: non-ST-segment-elevation acute coronary syndromes?

Output: American Heart Association Council on Clinical Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published Acute coronary care in the elderly, part I: non-ST-segment-elevation acute coronary syndromes?. ### Response: American Heart Association Council on Clinical Cardiology.


Instruction: Who collaborated with the Society of Geriatric Cardiology?

Output: American Heart Association Council on Clinical Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who collaborated with the Society of Geriatric Cardiology?. ### Response: American Heart Association Council on Clinical Cardiology.


Instruction: Circulation. 2007;115:2549-69. What is Gale CP, Cattle BA, Woolston A, et al. doing?

Output: Resolving inequalities in care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation. 2007;115:2549-69. What is Gale CP, Cattle BA, Woolston A, et al. doing?. ### Response: Resolving inequalities in care.


Instruction: What is non-HDL cholest erol?

Output: otal cholest erol minus HDL cholest erol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is non-HDL cholest erol?. ### Response: otal cholest erol minus HDL cholest erol.


Instruction: What is not directly measur ed but uses a f asting sample and trigly ceride levels to be less than 4.5 mmol/litr e?

Output: LDL cholest erol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not directly measur ed but uses a f asting sample and trigly ceride levels to be less than 4.5 mmol/litr e?. ### Response: LDL cholest erol.


Instruction: How many mmol/litr e does non-HDL cholest erol have?

Output: 4 .5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mmol/litr e does non-HDL cholest erol have?. ### Response: 4 .5.


Instruction: How many different int ensity categories are used for the purpose of his guideline?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many different int ensity categories are used for the purpose of his guideline?. ### Response: 3.


Instruction: What is the per centage r eduction in lo w-density lipopr otein cholest erol they produce?

Output: • low int ensity if t he reduction is 20%  to 30%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the per centage r eduction in lo w-density lipopr otein cholest erol they produce?. ### Response: • low int ensity if t he reduction is 20%  to 30%.


Instruction: What is low int ensity if the reduction is 20% to 30%?

Output: medium int ensity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is low int ensity if the reduction is 20% to 30%?. ### Response: medium int ensity.


Instruction: What is a high int ensity if t he reduction is abo ve 40%?

Output: medium int ensity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a high int ensity if t he reduction is abo ve 40%?. ### Response: medium int ensity.


Instruction: What is an appendix A for?

Output: fur ther details

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an appendix A for?. ### Response: fur ther details.


Instruction: What is a risk assessment and r eduction, including lipid modification?

Output: Cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk assessment and r eduction, including lipid modification?. ### Response: Cardiovascular disease.


Instruction: What is the name of the book that discusses cardiovascular disease?

Output: NICE 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the book that discusses cardiovascular disease?. ### Response: NICE 2023.


Instruction: What is the last updat ed 10 F ebruar y 2023Page 6of 40?

Output: Notice of right s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the last updat ed 10 F ebruar y 2023Page 6of 40?. ### Response: Notice of right s.


Instruction: How long after cath-eter ablation is stroke driven by discontinuation of oral anticoagulation?

Output: 3 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after cath-eter ablation is stroke driven by discontinuation of oral anticoagulation?. ### Response: 3 months.


Instruction: What is the DOI for 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: 10.1161/CIR.0000000000000923 e178CLINICAL STATEMENTS  AND GUIDELINESOtto

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the DOI for 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: 10.1161/CIR.0000000000000923 e178CLINICAL STATEMENTS  AND GUIDELINESOtto.


Instruction: What is driven chiefly by discontinuation of oral anticoagulation?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is driven chiefly by discontinuation of oral anticoagulation?. ### Response: stroke.


Instruction: Both US and European guideline statements on catheter ablation rec-ommend what?

Output: anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Both US and European guideline statements on catheter ablation rec-ommend what?. ### Response: anticoagulation.


Instruction: What should patients who have had surgical abla-tion be managed with?

Output: at least 3 months of anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients who have had surgical abla-tion be managed with?. ### Response: at least 3 months of anticoagulation.


Instruction: Who should be managed with at least 3 months of anticoagulation?

Output: patients who have had surgical abla-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should be managed with at least 3 months of anticoagulation?. ### Response: patients who have had surgical abla-tion.


Instruction: What should be based on evaluation of arrhythmia recurrence in the context of their CHA2DS2-VASc score?

Output: Subsequent anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be based on evaluation of arrhythmia recurrence in the context of their CHA2DS2-VASc score?. ### Response: Subsequent anticoagulation.


Instruction: What would be the preferred method of anticoagulation for the first 3 months?

Output: VKA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would be the preferred method of anticoagulation for the first 3 months?. ### Response: VKA.


Instruction: What is a higher incidence of early AF in all patients after LA appendage occlusion/exclusion?

Output: dem-onstrated

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a higher incidence of early AF in all patients after LA appendage occlusion/exclusion?. ### Response: dem-onstrated.


Instruction: What has been dem-onstrated in patients after LA appendage occlusion/exclusion?

Output: A higher incidence of early AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been dem-onstrated in patients after LA appendage occlusion/exclusion?. ### Response: A higher incidence of early AF.


Instruction: What is not recommended in patients with-out preexisting AF?

Output: pre-emptive LA appendage occlusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended in patients with-out preexisting AF?. ### Response: pre-emptive LA appendage occlusion.


Instruction: No stroke benefit has been observed in this group of patients with no preemptive history of what?

Output: AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No stroke benefit has been observed in this group of patients with no preemptive history of what?. ### Response: AF.


Instruction: What group of patients have no preemptive history of AF.15?

Output: No stroke benefit has been observed in this group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What group of patients have no preemptive history of AF.15?. ### Response: No stroke benefit has been observed in this group.


Instruction: What is recommended for Diagnosis in Patients With VHD Undergoing Noncardiac Surgery?

Output: COR LOE Recommendation1 C-EO1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for Diagnosis in Patients With VHD Undergoing Noncardiac Surgery?. ### Response: COR LOE Recommendation1 C-EO1.


Instruction: In patients with clinical suspected moderate or greater degrees of what?

Output: valvular stenosis or regurgitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with clinical suspected moderate or greater degrees of what?. ### Response: valvular stenosis or regurgitation.


Instruction: Preoperative echocardiography is recommended for patients with what type of stenosis or regurgitation?

Output: valvular

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Preoperative echocardiography is recommended for patients with what type of stenosis or regurgitation?. ### Response: valvular.


Instruction: What is the type of evaluation of patients with VHD who are undergoing noncardiac surgery dependent on?

Output: the type

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the type of evaluation of patients with VHD who are undergoing noncardiac surgery dependent on?. ### Response: the type.


Instruction: What indicates atrial fibrillation?

Output: AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates atrial fibrillation?. ### Response: AF.


Instruction: What indicates valvular heart disease?

Output: VHD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates valvular heart disease?. ### Response: VHD.


Instruction: Who were recruited within the community?

Output: those who were recruited within the community. For the outcome all -cause mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who were recruited within the community?. ### Response: those who were recruited within the community. For the outcome all -cause mortality.


Instruction: How many studies were included for the outcome all -cause mortality?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were included for the outcome all -cause mortality?. ### Response: 1.


Instruction: What was the quality of the evidence?

Output: very low

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the quality of the evidence?. ### Response: very low.


Instruction: What did the outcome all-cause hospitalisations contain?

Output: the same study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the outcome all-cause hospitalisations contain?. ### Response: the same study.


Instruction: What did a single study rated as very low quality show for the outcome QoL?

Output: a clinically important improvement in QoL using both the MLWHF and KCCQ HRQoL scales

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a single study rated as very low quality show for the outcome QoL?. ### Response: a clinically important improvement in QoL using both the MLWHF and KCCQ HRQoL scales.


Instruction: How many studies were rated as very low quality?

Output: n=50

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were rated as very low quality?. ### Response: n=50.


Instruction: What scales showed a clinically important improvement in QoL?

Output: MLWHF and KCCQ HRQoL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What scales showed a clinically important improvement in QoL?. ### Response: MLWHF and KCCQ HRQoL.


Instruction: What does smoking cessation reduce in mortality in smokers?

Output: 15% over 14 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does smoking cessation reduce in mortality in smokers?. ### Response: 15% over 14 years.


Instruction: What is the definition of a body mass index 30 kg/m2?

Output: obesity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the definition of a body mass index 30 kg/m2?. ### Response: obesity.


Instruction: How much of the adult US population is obese?

Output: ≈30%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the adult US population is obese?. ### Response: ≈30%.


Instruction: How much of the adult US population falls into this category in recent years?

Output: ≈30%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the adult US population falls into this category in recent years?. ### Response: ≈30%.


Instruction: What is the positive rela-tionship between obesity and BP well documented?

Output: 39–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the positive rela-tionship between obesity and BP well documented?. ### Response: 39–.


Instruction: How much more likely are obese adults to be hypertensive compared with nonobese adults?

Output: ≈3 times

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much more likely are obese adults to be hypertensive compared with nonobese adults?. ### Response: ≈3 times.


Instruction: What may explain >60% of hypertension in adults?

Output: increased adiposity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may explain >60% of hypertension in adults?. ### Response: increased adiposity.


Instruction: What is considered a major risk factor for poor BP control in hypertensive patients?

Output: obesity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is considered a major risk factor for poor BP control in hypertensive patients?. ### Response: obesity.


Instruction: What is RAAS?

Output: renin-angiotensin-aldosterone system

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is RAAS?. ### Response: renin-angiotensin-aldosterone system.


Instruction: There is no acceptable guideline on the antihypertensive drug of choice for the management of hypertension among obese patients?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is no acceptable guideline on the antihypertensive drug of choice for the management of hypertension among obese patients?. ### Response: 3.


Instruction: Why do investigators consider ACE inhibitors the drugs of choice?

Output: their capacity to increase insulin sensitivity and thus reduce the risk of diabetes mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why do investigators consider ACE inhibitors the drugs of choice?. ### Response: their capacity to increase insulin sensitivity and thus reduce the risk of diabetes mellitus.


Instruction: What does thiazide diuretics do in obesity-related hypertension?

Output: lowering BP and improving cardiovascular out-comes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does thiazide diuretics do in obesity-related hypertension?. ### Response: lowering BP and improving cardiovascular out-comes.


Instruction: What is the capacity of adequate BP control in obesity related hypertension?

Output: lifestyle interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the capacity of adequate BP control in obesity related hypertension?. ### Response: lifestyle interventions.


Instruction: Which drugs are associated with increased risk of diabetes mellitus?

Output: thiazide diuretics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which drugs are associated with increased risk of diabetes mellitus?. ### Response: thiazide diuretics.


Instruction: What is the efficacy of thiazide diuretics in lowering BP and improving cardiovascular out-comes in obese hypertensive patients?

Output: well established

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the efficacy of thiazide diuretics in lowering BP and improving cardiovascular out-comes in obese hypertensive patients?. ### Response: well established.


Instruction: -Blockers also have adverse effects on glucose metabolism but have led to significant improvement in what?

Output: BP in obese

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: -Blockers also have adverse effects on glucose metabolism but have led to significant improvement in what?. ### Response: BP in obese.


Instruction: What do -blockers decrease in obese patients?

Output: renin activity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do -blockers decrease in obese patients?. ### Response: renin activity.


Instruction: What are renin activity and cardiac output often elevated in?

Output: obese patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are renin activity and cardiac output often elevated in?. ### Response: obese patients.


Instruction: Why is enthusiasm for the use of a  blocker dampened by their negative profile on stroke outcomes?

Output: placebo and other antihypertensive drug classes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is enthusiasm for the use of a  blocker dampened by their negative profile on stroke outcomes?. ### Response: placebo and other antihypertensive drug classes.


Instruction: What are antihypertensive drug classes?

Output: placebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are antihypertensive drug classes?. ### Response: placebo.


Instruction: What is abundant evidence in support of the effectiveness of lifestyle interventions in improving BP control?

Output: 49There is abundant evidence in support of the effectiveness of lifestyle interventions in improving BP control among obese hypertensive patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is abundant evidence in support of the effectiveness of lifestyle interventions in improving BP control?. ### Response: 49There is abundant evidence in support of the effectiveness of lifestyle interventions in improving BP control among obese hypertensive patients.


Instruction: What do adults need to do to lose weight?

Output: identi-fying

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do adults need to do to lose weight?. ### Response: identi-fying.


Instruction: What is the AHA/ACC guidelines docu-ment on?

Output: lifestyle management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the AHA/ACC guidelines docu-ment on?. ### Response: lifestyle management.


Instruction: What do AHA/ACC guidelines docu-ment on?

Output: lifestyle management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do AHA/ACC guidelines docu-ment on?. ### Response: lifestyle management.


Instruction: What are the two main topics of the guidelines?

Output: matching treatment benefits with risk profiles, diets for weight loss, lifestyle

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the two main topics of the guidelines?. ### Response: matching treatment benefits with risk profiles, diets for weight loss, lifestyle.


Instruction: What did the AHA publish in 2002?

Output: “Unique Features of Infective Endocarditis in Childhood

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the AHA publish in 2002?. ### Response: “Unique Features of Infective Endocarditis in Childhood.


Instruction: What was the focus of the 2002 AHA Scientific Statement?

Output: Infective Endocarditis in Childhood

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the focus of the 2002 AHA Scientific Statement?. ### Response: Infective Endocarditis in Childhood.


Instruction: When did other AHA reports focus on new recommendations for treatment of IE in adults?

Output: 20052

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did other AHA reports focus on new recommendations for treatment of IE in adults?. ### Response: 20052.


Instruction: When did AHA report on major changes regarding IE prevention?

Output: 20073

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did AHA report on major changes regarding IE prevention?. ### Response: 20073.


Instruction: What does this document update?

Output: outpatient management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does this document update?. ### Response: outpatient management.


Instruction: How does IE affect infants and children?

Output: specific atten-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does IE affect infants and children?. ### Response: specific atten-tion.


Instruction: What is the impact of increased survival for children with congenital heart disease on the epidemiology of IE updated?

Output: newer tools useful for diagnosis and treatment in the pediatric popula-tion are reviewed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact of increased survival for children with congenital heart disease on the epidemiology of IE updated?. ### Response: newer tools useful for diagnosis and treatment in the pediatric popula-tion are reviewed.


Instruction: How are new tools useful for diagnosis and treatment in the pediatric popula-tion reviewed?

Output: This review emphasizes changing manage-ment perspectives and discussion of new agents that have utility for treatment of resistant organisms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are new tools useful for diagnosis and treatment in the pediatric popula-tion reviewed?. ### Response: This review emphasizes changing manage-ment perspectives and discussion of new agents that have utility for treatment of resistant organisms.


Instruction: What is the focus of this review?

Output: changing manage-ment perspectives and discussion of new agents that have utility for treatment of resistant organisms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the focus of this review?. ### Response: changing manage-ment perspectives and discussion of new agents that have utility for treatment of resistant organisms.


Instruction: What is critical to the diagnosis and management of children with IE?

Output: proper use of the diagnostic microbiology laboratory

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is critical to the diagnosis and management of children with IE?. ### Response: proper use of the diagnostic microbiology laboratory.


Instruction: What has improved sensitivity and specificity for confirming the diagnosis of IE?

Output: newer diag-nostic guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has improved sensitivity and specificity for confirming the diagnosis of IE?. ### Response: newer diag-nostic guidelines.


Instruction: Why is home intravenous therapy available?

Output: improved infrastructure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is home intravenous therapy available?. ### Response: improved infrastructure.


Instruction: What is an increasingly accepted approach for stable patients who are at low risk for complica-tions?

Output: outpatient management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an increasingly accepted approach for stable patients who are at low risk for complica-tions?. ### Response: outpatient management.


Instruction: What are stable patients who are at low risk for complica-tions?

Output: outpatient management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are stable patients who are at low risk for complica-tions?. ### Response: outpatient management.


Instruction: Since the publication of the last AHA document on pediatric IE, what have the recommendations for prevention of IE been modified substantially?

Output: pediatric cardiovascular concerns

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Since the publication of the last AHA document on pediatric IE, what have the recommendations for prevention of IE been modified substantially?. ### Response: pediatric cardiovascular concerns.


Instruction: What are incorporated from the perspective of pediatric cardiovascular concerns?

Output: the most current recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are incorporated from the perspective of pediatric cardiovascular concerns?. ### Response: the most current recommendations.


Instruction: There are not likely to be any randomized con-trolled trials for treatment of what?

Output: IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There are not likely to be any randomized con-trolled trials for treatment of what?. ### Response: IE.


Instruction: Many of the indications are based on what type of consensus?

Output: consensus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Many of the indications are based on what type of consensus?. ### Response: consensus.


Instruction: What are indications based on?

Output: consensus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are indications based on?. ### Response: consensus.


Instruction: What was des-ignated as Class I indications?

Output: interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was des-ignated as Class I indications?. ### Response: interventions.


Instruction: Where the wording of treatments indicates a recommendation, what classification is used?

Output: standard

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where the wording of treatments indicates a recommendation, what classification is used?. ### Response: standard.


Instruction: What classification system is used for recommendations?

Output: ACC/AHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What classification system is used for recommendations?. ### Response: ACC/AHA.


Instruction: What is the strength of the recommendation according to?

Output: ACC/AHA classification system for recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the strength of the recommendation according to?. ### Response: ACC/AHA classification system for recommendations.


Instruction: How often does IE occur in children?

Output: less often

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often does IE occur in children?. ### Response: less often.


Instruction: How many pediatric admissions per year were there between 1972 and 1982?

Output: 1 in 1280

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many pediatric admissions per year were there between 1972 and 1982?. ### Response: 1 in 1280.


Instruction: What was the annual incidence rate in the United States between 2003 and 2010?

Output: between approximately 0.05 and 0.12 cases per 1000 pediatric admissions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the annual incidence rate in the United States between 2003 and 2010?. ### Response: between approximately 0.05 and 0.12 cases per 1000 pediatric admissions.


Instruction: How many pediatric admissions were there between 2003 and 2010?

Output: between approximately 0.05 and 0.12 cases per 1000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many pediatric admissions were there between 2003 and 2010?. ### Response: between approximately 0.05 and 0.12 cases per 1000.


Instruction: What is the reported hos-pitalization rates for IE?

Output: vary considerably among published

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the reported hos-pitalization rates for IE?. ### Response: vary considerably among published.


Instruction: What can be used to identify children who are at high risk of stroke and who benefit from transfusion therapy?

Output: TCD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be used to identify children who are at high risk of stroke and who benefit from transfusion therapy?. ### Response: TCD.


Instruction: What remains the most extensively validated method for risk assessment?

Output: TCD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What remains the most extensively validated method for risk assessment?. ### Response: TCD.


Instruction: What is an extensively validated method for risk assessment?

Output: TCD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an extensively validated method for risk assessment?. ### Response: TCD.


Instruction: What are some additional predictors that may come from incorporating?

Output: anterior cerebral artery velocity, blood biomarkers, variations in several genes, and nocturnal oxygen saturation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some additional predictors that may come from incorporating?. ### Response: anterior cerebral artery velocity, blood biomarkers, variations in several genes, and nocturnal oxygen saturation.


Instruction: On the basis of STOP II, even those whose risk of stroke decreases with transfusion therapy decreases?

Output: ≈50% probability of reverting to high risk or having a stroke if transfusion therapy is discontinued

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On the basis of STOP II, even those whose risk of stroke decreases with transfusion therapy decreases?. ### Response: ≈50% probability of reverting to high risk or having a stroke if transfusion therapy is discontinued.


Instruction: What is the risk of stroke that decreases with transfusion therapy?

Output: ≈50% probability of reverting to high risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of stroke that decreases with transfusion therapy?. ### Response: ≈50% probability of reverting to high risk.


Instruction: What is a 50% probability of reverting to high risk or having a stroke if transfusion is discontinued?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a 50% probability of reverting to high risk or having a stroke if transfusion is discontinued?. ### Response: ≈.


Instruction: Why do studies show the need for ongoing active treatment despite TCD normaliza-tion and the risk of iron toxicity with repeated transfusions?

Output: Alternative methods of maintenance therapy that are safer than transfusion need to be developed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why do studies show the need for ongoing active treatment despite TCD normaliza-tion and the risk of iron toxicity with repeated transfusions?. ### Response: Alternative methods of maintenance therapy that are safer than transfusion need to be developed.


Instruction: Predictive methods other than TCD (eg, MRI techniques) need to be systematically compared and combined with what?

Output: TCD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Predictive methods other than TCD (eg, MRI techniques) need to be systematically compared and combined with what?. ### Response: TCD.


Instruction: What may be beneficial when red cell transfusions are downloaded from http://ahajournals.org by on April 28, 2023?

Output: Hydroxyurea

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be beneficial when red cell transfusions are downloaded from http://ahajournals.org by on April 28, 2023?. ### Response: Hydroxyurea.


Instruction: What is the risk of recurrence of hyper tensi ve disorders of pregnanc y and long-term c ardiovascular dise ase?

Output: Risk o f recurr ence of hyper tensi ve disor ders of pregnanc y and long-term c ardiovascular dise ase Recommendations 1 .10.1 to 1.10.4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of recurrence of hyper tensi ve disorders of pregnanc y and long-term c ardiovascular dise ase?. ### Response: Risk o f recurr ence of hyper tensi ve disor ders of pregnanc y and long-term c ardiovascular dise ase Recommendations 1 .10.1 to 1.10.4.


Instruction: Long-t erm f ollow-up studies of w omen who ha ve experienced h yper tensiv e disor ders during pr egnancy sho wed an incr eased risk of what?

Output: long-t erm car diovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Long-t erm f ollow-up studies of w omen who ha ve experienced h yper tensiv e disor ders during pr egnancy sho wed an incr eased risk of what?. ### Response: long-t erm car diovascular disease.


Instruction: What did a higher pr evalence of h yper tensiv e disor ders compare with women unaff ected with?

Output: hyper tensiv e disor ders

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a higher pr evalence of h yper tensiv e disor ders compare with women unaff ected with?. ### Response: hyper tensiv e disor ders.


Instruction: There was no evidence on which int erventions could r educe t he risk of what?

Output: r ecurr ence of hyper tensiv e disor ders of pr egnancy or futur e car diovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There was no evidence on which int erventions could r educe t he risk of what?. ### Response: r ecurr ence of hyper tensiv e disor ders of pr egnancy or futur e car diovascular disease.


Instruction: What is the risk of hyper tensiv e disorders of pregnancy or futur e car diovascular disease?

Output: Ther e was no e vidence on which int erventions could r educe t he risk of r ecurr ence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of hyper tensiv e disorders of pregnancy or futur e car diovascular disease?. ### Response: Ther e was no e vidence on which int erventions could r educe t he risk of r ecurr ence.


Instruction: How do the r ecommenda tions mig ht affect practice?

Output: Providing guidance and advice t o women on futur e risks and signposting appr opriat e car e and lif estyle advice ma y be an additional activity f or some healt hcare professionals, compar ed wit h curr ent practice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do the r ecommenda tions mig ht affect practice?. ### Response: Providing guidance and advice t o women on futur e risks and signposting appr opriat e car e and lif estyle advice ma y be an additional activity f or some healt hcare professionals, compar ed wit h curr ent practice.


Instruction: What could be an additional activity for some healt hcare professionals?

Output: Providing guidance and advice t o women on futur e risks and signposting appr opriat e car e and lif estyle advice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could be an additional activity for some healt hcare professionals?. ### Response: Providing guidance and advice t o women on futur e risks and signposting appr opriat e car e and lif estyle advice.


Instruction: What is the name of the book that describes hyper tension in pregnancy?

Output: NG133

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the book that describes hyper tension in pregnancy?. ### Response: NG133.


Instruction: When is the book NG133 published?

Output: NICE 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is the book NG133 published?. ### Response: NICE 2023.


Instruction: What date was the last updat ed?

Output: 17 April 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What date was the last updat ed?. ### Response: 17 April 2023.


Instruction: How many pages of 59 are on this page?

Output: 53

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many pages of 59 are on this page?. ### Response: 53.


Instruction: What will have event rates 7.5%?

Output: artery calcium scores of zero

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will have event rates 7.5%?. ### Response: artery calcium scores of zero.


Instruction: What can help guide shared decision-making about statins?

Output: artery calcium scores of zero will have event rates <7.5%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can help guide shared decision-making about statins?. ### Response: artery calcium scores of zero will have event rates <7.5%,.


Instruction: What is a risk factor for premature ASCVD?

Output: Family history

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for premature ASCVD?. ### Response: Family history.


Instruction: What is the risk factor of primary hypercholesterolemia?

Output: ≥175 mg/dL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk factor of primary hypercholesterolemia?. ### Response: ≥175 mg/dL.


Instruction: How many mg/dL of LDL-C does a person have?

Output: >160

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mg/dL of LDL-C does a person have?. ### Response: >160.


Instruction: What type of kidney disease is not treated with dialysis or kidney transplantation?

Output: albuminuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of kidney disease is not treated with dialysis or kidney transplantation?. ### Response: albuminuria.


Instruction: How many factors make a diagnosis of chronic kidney disease?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many factors make a diagnosis of chronic kidney disease?. ### Response: 3.


Instruction: What are some chronic inflammatory conditions?

Output: psoriasis, RA, lupus, or HIV/AIDS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some chronic inflammatory conditions?. ### Response: psoriasis, RA, lupus, or HIV/AIDS.


Instruction: What is an example of a pregnancy-associated condition that increases later ASCVD risk?

Output: preeclampsia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a pregnancy-associated condition that increases later ASCVD risk?. ### Response: preeclampsia.


Instruction: Which race/ethnicity is associated with an increased risk of asCVD?

Output: South Asian ancestry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which race/ethnicity is associated with an increased risk of asCVD?. ### Response: South Asian ancestry.


Instruction: What type of ancestry is associated with increased ASCVD risk?

Output: South Asian

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of ancestry is associated with increased ASCVD risk?. ### Response: South Asian.


Instruction: What is a relative indication for its measurement?

Output: family history of premature ASCVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a relative indication for its measurement?. ### Response: family history of premature ASCVD.


Instruction: What is a risk-enhancing factor at higher levels of Lp(a)?

Output: An Lp(a) ≥50 mg/dL or ≥125 nmol/L

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk-enhancing factor at higher levels of Lp(a)?. ### Response: An Lp(a) ≥50 mg/dL or ≥125 nmol/L.


Instruction: What is the relative indication for the measurement of Elevated apoB?

Output: triglyceride ≥200 mg/dL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the relative indication for the measurement of Elevated apoB?. ### Response: triglyceride ≥200 mg/dL.


Instruction: A level 130 mg/dL corresponds to what?

Output: an LDL-C >160 mg/dL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A level 130 mg/dL corresponds to what?. ### Response: an LDL-C >160 mg/dL.


Instruction: What constitutes a risk-enhancing factor ABI?

Output: LDL-C >160 mg/dL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What constitutes a risk-enhancing factor ABI?. ### Response: LDL-C >160 mg/dL.


Instruction: ABI indicates ankle-brachial index, what does AIDS mean?

Output: acquired immunodeficiency syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ABI indicates ankle-brachial index, what does AIDS mean?. ### Response: acquired immunodeficiency syndrome.


Instruction: What is HDL-C?

Output: high-density lipoprotein cholesterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is HDL-C?. ### Response: high-density lipoprotein cholesterol.


Instruction: What is HIV?

Output: human immunodeficiency virus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is HIV?. ### Response: human immunodeficiency virus.


Instruction: Where can you find the original version of this article?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find the original version of this article?. ### Response: http://ahajournals.org.


Instruction: When was this article published?

Output: May 1, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this article published?. ### Response: May 1, 2023.


Instruction: What is NICE 2023?

Output: All right s reserved

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE 2023?. ### Response: All right s reserved.


Instruction: What is the last date of updat?

Output: 13 April 2022

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the last date of updat?. ### Response: 13 April 2022.


Instruction: What is a shor t-acting nitrat e for?

Output: treat episodes of angina

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a shor t-acting nitrat e for?. ### Response: treat episodes of angina.


Instruction: How do people with stable angina know how to use a skor t -act ing?

Output: no e vidence t hat t hey help stable angina

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do people with stable angina know how to use a skor t -act ing?. ### Response: no e vidence t hat t hey help stable angina.


Instruction: What is an example of an angina that can be used to prevent and tr eating episodes?

Output: nitrat e

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of an angina that can be used to prevent and tr eating episodes?. ### Response: nitrat e.


Instruction: What are some of the side effects of a xercise?

Output: flushing, headache and light -headedness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the side effects of a xercise?. ### Response: flushing, headache and light -headedness.


Instruction: What is a side effect of using a pen?

Output: flushing, headache and light -headedness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a side effect of using a pen?. ### Response: flushing, headache and light -headedness.


Instruction: What do people need to do if feeling light-headed?

Output: sit do wn or find somet hing t o hold on t o

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do people need to do if feeling light-headed?. ### Response: sit do wn or find somet hing t o hold on t o.


Instruction: What is a shor t-acting nitrat e being used to treat episodes of angina?

Output: 1.3.4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a shor t-acting nitrat e being used to treat episodes of angina?. ### Response: 1.3.4.


Instruction: What should you do if the pain has not gone?

Output: call an emer gency ambulance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should you do if the pain has not gone?. ### Response: call an emer gency ambulance.


Instruction: How long after taking a second dose of aspirin should you call an emergency ambulance?

Output: 5  minut es

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after taking a second dose of aspirin should you call an emergency ambulance?. ### Response: 5  minut es.


Instruction: What is an example of a drug that can be used to prevent cardiovascular disease?

Output: aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a drug that can be used to prevent cardiovascular disease?. ### Response: aspirin.


Instruction: How many mg of aspirin should people take daily for stable angina?

Output: 7 5 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mg of aspirin should people take daily for stable angina?. ### Response: 7 5 mg.


Instruction: What does A CE stand for?

Output: angiot ensin-con verting enzyme

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does A CE stand for?. ### Response: angiot ensin-con verting enzyme.


Instruction: How much does ACE inhibit angina and diabetes?

Output: angiot ensin-con verting enzyme (A CE) inhibit ors f

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much does ACE inhibit angina and diabetes?. ### Response: angiot ensin-con verting enzyme (A CE) inhibit ors f.


Instruction: What type of angina can be offered in line with NICE guidance?

Output: stable

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of angina can be offered in line with NICE guidance?. ### Response: stable.


Instruction: What is the NICE guideline on lipid modification?

Output: 1.3.7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the NICE guideline on lipid modification?. ### Response: 1.3.7.


Instruction: What should be offered in line with the NICE guideline on hyper tension?

Output: treatment f or high blood pr essur e

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be offered in line with the NICE guideline on hyper tension?. ### Response: treatment f or high blood pr essur e.


Instruction: What do not offer vitamin or fish oil supplements to treat?

Output: stable angina

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do not offer vitamin or fish oil supplements to treat?. ### Response: stable angina.


Instruction: Stable angina: management (CG126) NICE 2022. All right s reserved.

Output: iot ensin-con verting enzyme (A CE) inhibit ors f or people wit h stable angina and diabet es. Off er or continue A CE inhibit ors f or ot her conditions, in line wit h relevant NICE guidance. 1.3.7 Offer statin tr eatment in line wit h the NICE guideline on lipid modification . 1.3.8 Offer treatment f or high blood pr essur e in line wit h the NICE guideline on hyper tension . Dietary supp lemen ts 1.3.9 Do not off er vitamin or fish oil supplement s to treat stable angina. Inf orm people t hat t here is no e vidence t hat t hey help stable angina

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Stable angina: management (CG126) NICE 2022. All right s reserved.. ### Response: iot ensin-con verting enzyme (A CE) inhibit ors f or people wit h stable angina and diabet es. Off er or continue A CE inhibit ors f or ot her conditions, in line wit h relevant NICE guidance. 1.3.7 Offer statin tr eatment in line wit h the NICE guideline on lipid modification . 1.3.8 Offer treatment f or high blood pr essur e in line wit h the NICE guideline on hyper tension . Dietary supp lemen ts 1.3.9 Do not off er vitamin or fish oil supplement s to treat stable angina. Inf orm people t hat t here is no e vidence t hat t hey help stable angina.


Instruction: What is the last updat ed 25 August 2016?

Output: Page 11of 26

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the last updat ed 25 August 2016?. ### Response: Page 11of 26.


Instruction: What is erms-and-conditions#notice-of-right s?

Output: https://www .nice.or g.uk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is erms-and-conditions#notice-of-right s?. ### Response: https://www .nice.or g.uk.


Instruction: Last updat ed 25 August 2016?

Output: 11of 26

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Last updat ed 25 August 2016?. ### Response: 11of 26.


Instruction: What is not feasible but should not be considered as a substitute for transfusion?

Output: Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not feasible but should not be considered as a substitute for transfusion?. ### Response: Stroke.


Instruction: What is needed to develop a stroke prevention strategy for adults?

Output: Data on risk of stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed to develop a stroke prevention strategy for adults?. ### Response: Data on risk of stroke.


Instruction: What type of tri-als are needed for adults with SCD?

Output: Future stroke prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of tri-als are needed for adults with SCD?. ### Response: Future stroke prevention.


Instruction: When is TCD screening indicated for children?

Output: starting at 2 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is TCD screening indicated for children?. ### Response: starting at 2 years of age.


Instruction: What is the target reduction of hemoglobin S, 30%?

Output: <30%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the target reduction of hemoglobin S, 30%?. ### Response: <30%).


Instruction: What is effective for reducing stroke risk in children at elevated risk?

Output: Transfusion therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is effective for reducing stroke risk in children at elevated risk?. ### Response: Transfusion therapy.


Instruction: What is the optimal screening interval?

Output: Class IIa

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the optimal screening interval?. ### Response: Class IIa.


Instruction: What should be screened more frequently to detect the development of high-risk TCD indications for intervention?

Output: younger children and those with borderline abnormal TCD velocities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be screened more frequently to detect the development of high-risk TCD indications for intervention?. ### Response: younger children and those with borderline abnormal TCD velocities.


Instruction: What is probably indicated even in those whose TCD velocities revert to normal?

Output: continued transfusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is probably indicated even in those whose TCD velocities revert to normal?. ### Response: continued transfusion.


Instruction: What type of transplantation is indicated in children at high risk for stroke?

Output: Transfusion therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of transplantation is indicated in children at high risk for stroke?. ### Response: Transfusion therapy.


Instruction: What kind of urea might be considered in children who are unable or unwilling to be treated?

Output: hydroxyurea

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What kind of urea might be considered in children who are unable or unwilling to be treated?. ### Response: hydroxyurea.


Instruction: What is a Class IIb; Level of Evidence B?

Output: hydroxyurea or bone marrow transplantation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a Class IIb; Level of Evidence B?. ### Response: hydroxyurea or bone marrow transplantation.


Instruction: What are not recom-mendations in place of TCD for primary stroke prevention?

Output: MRI and MRA criteria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are not recom-mendations in place of TCD for primary stroke prevention?. ### Response: MRI and MRA criteria.


Instruction: What class is migraine headache?

Output: aura

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What class is migraine headache?. ### Response: aura.


Instruction: What is migraine most commonly associated with in young women?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is migraine most commonly associated with in young women?. ### Response: stroke.


Instruction: How many studies reported an overall pooled RR of 2.04?

Output: 21

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies reported an overall pooled RR of 2.04?. ### Response: 21.


Instruction: What was the overall pooled RR of migraine with aura?

Output: 2.16

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the overall pooled RR of migraine with aura?. ### Response: 2.16.


Instruction: How was the risk of migraine without aura compared to the association of ischemic stroke?

Output: greater

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the risk of migraine without aura compared to the association of ischemic stroke?. ### Response: greater.


Instruction: What percentage of the CI was 0.81-2.06?

Output: 95%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the CI was 0.81-2.06?. ### Response: 95%.


Instruction: How many studies reported a pooled RR between any migraine and ischemic stroke?

Output: 9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies reported a pooled RR between any migraine and ischemic stroke?. ### Response: 9.