Instruction: When should a focused update be commis-sioned?

Output: May 3, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When should a focused update be commis-sioned?. ### Response: May 3, 2023.


Instruction: What do readers need to download from http://ahajournals.org?

Output: guideline development, we encourage readers to Downloaded from http://ahajournals.org by on May 3, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do readers need to download from http://ahajournals.org?. ### Response: guideline development, we encourage readers to Downloaded from http://ahajournals.org by on May 3, 2023.


Instruction: What is routine use not recommended in these settings?

Output: prophylactic aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is routine use not recommended in these settings?. ### Response: prophylactic aspirin.


Instruction: There is insufficient evidence to comment on whether there may be select circumstances in which physi-cians might discuss prophylactic aspirin with adults 40 years of age or >70 years old in the context of?

Output: other known ASCVD risk factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is insufficient evidence to comment on whether there may be select circumstances in which physi-cians might discuss prophylactic aspirin with adults 40 years of age or >70 years old in the context of?. ### Response: other known ASCVD risk factors.


Instruction: What are some other known ASCVD risk factors?

Output: strong family history of premature MI, inability to achieve lipid or BP or glucose targets, or significant eleva-tion in coronary artery calcium score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some other known ASCVD risk factors?. ### Response: strong family history of premature MI, inability to achieve lipid or BP or glucose targets, or significant eleva-tion in coronary artery calcium score.


Instruction: What is the reason for the lack of a justification for the recommendation?

Output: an inadequate literature base

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the reason for the lack of a justification for the recommendation?. ### Response: an inadequate literature base.


Instruction: What is low-dose aspirin used for in primary prevention of ASCVD among adults at low estimated risk?

Output: there is also no justification for the routine administration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is low-dose aspirin used for in primary prevention of ASCVD among adults at low estimated risk?. ### Response: there is also no justification for the routine administration.


Instruction: What is the name of the recent ARRIVE trial?

Output: A Randomized Trial of Induction Versus Expectant Management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the recent ARRIVE trial?. ### Response: A Randomized Trial of Induction Versus Expectant Management.


Instruction: Induction Versus Expectant Management) trial, what was the observed average 10-year ASCVD risk?

Output: <10%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Induction Versus Expectant Management) trial, what was the observed average 10-year ASCVD risk?. ### Response: <10%,.


Instruction: What was the overall benefits of prophylactic aspirin by intention-to-treat negligible?

Output: <10%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the overall benefits of prophylactic aspirin by intention-to-treat negligible?. ### Response: <10%,.


Instruction: The accumulated trial and observational data to date support avoiding what in the setting of known risk factors?

Output: prophylactic aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The accumulated trial and observational data to date support avoiding what in the setting of known risk factors?. ### Response: prophylactic aspirin.


Instruction: What is a nonexhaustive list of conditions associated with increased bleeding risk?

Output: a history of previous gastrointestinal bleeding or peptic ulcer disease or bleeding at other sites

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a nonexhaustive list of conditions associated with increased bleeding risk?. ### Response: a history of previous gastrointestinal bleeding or peptic ulcer disease or bleeding at other sites.


Instruction: A history of previous gastrointestinal bleeding or peptic ulcer disease or bleeding at other sites are examples of what?

Output: nonexhaustive list of conditions associated with increased bleeding risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A history of previous gastrointestinal bleeding or peptic ulcer disease or bleeding at other sites are examples of what?. ### Response: nonexhaustive list of conditions associated with increased bleeding risk.


Instruction: Nonsteroidal anti-inflammatory drugs, steroids, direct oral anti-coagulants, and warfarin are examples of what?

Output: concurrent use of other medications that increase bleeding risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Nonsteroidal anti-inflammatory drugs, steroids, direct oral anti-coagulants, and warfarin are examples of what?. ### Response: concurrent use of other medications that increase bleeding risk.


Instruction: COST AND VALUE CONSIDERATIONSThe growing need to consider value stems directly from the goal of achieving the best possible health outcomes with what resources?

Output: finite healthcare resources

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: COST AND VALUE CONSIDERATIONSThe growing need to consider value stems directly from the goal of achieving the best possible health outcomes with what resources?. ### Response: finite healthcare resources.


Instruction: What can be defined as the incremental health benefits of a therapy or procedure relative to its incremental net long-term costs?

Output: Value in health care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be defined as the incremental health benefits of a therapy or procedure relative to its incremental net long-term costs?. ### Response: Value in health care.


Instruction: The consideration of cost and value in the guideline development process supports key goals?

Output: achieving the best possible health outcomes with finite healthcare resources

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The consideration of cost and value in the guideline development process supports key goals?. ### Response: achieving the best possible health outcomes with finite healthcare resources.


Instruction: What is one of the key goals of the guideline development process?

Output: enhancing overall value in the de-livery of cardiovascular care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the key goals of the guideline development process?. ### Response: enhancing overall value in the de-livery of cardiovascular care.


Instruction: What is another key goal of the Guideline Development Process?

Output: enhancing overall value in the de-livery of cardiovascular care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another key goal of the Guideline Development Process?. ### Response: enhancing overall value in the de-livery of cardiovascular care.


Instruction: In addition to enhancing overall value in the delivery of cardiovascular care, what other goal involves involving health-care professionals in the challenging care decisions?

Output: de-livery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In addition to enhancing overall value in the delivery of cardiovascular care, what other goal involves involving health-care professionals in the challenging care decisions?. ### Response: de-livery.


Instruction: What type of chal-lenges are inherent in the integration of value assessments into our na-tional guidelines?

Output: methodological

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of chal-lenges are inherent in the integration of value assessments into our na-tional guidelines?. ### Response: methodological.


Instruction: What are some of the inherent methodological challenges of the integration?

Output: variability in costs across different healthcare

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the inherent methodological challenges of the integration?. ### Response: variability in costs across different healthcare.


Instruction: Who bears the burden of the health outcome?

Output: the individual patient

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who bears the burden of the health outcome?. ### Response: the individual patient.


Instruction: What is often spread beyond the individual to third-party pay-ers?

Output: healthcare cost

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is often spread beyond the individual to third-party pay-ers?. ### Response: healthcare cost.


Instruction: What is the purpose of this study?

Output: avoiding prophylactic aspirin in the setting of known risk factors for increased bleeding outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of this study?. ### Response: avoiding prophylactic aspirin in the setting of known risk factors for increased bleeding outcomes.


Instruction: When will this study be released?

Output: May 1, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When will this study be released?. ### Response: May 1, 2023.


Instruction: Where can you find this report?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find this report?. ### Response: http://ahajournals.org.


Instruction: What is the focus of the 2018 Cholesterol Clinical Practice GuidelinesCirculation. 2019;139:e1082–e1143. DOI: 10.1161/CIR.0000000000000625 June 18/25, 2019 e1085CLINICAL STATEMENTS AND GUIDELINESmembers volunteer their time to what?

Output: writ-ing and review efforts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the focus of the 2018 Cholesterol Clinical Practice GuidelinesCirculation. 2019;139:e1082–e1143. DOI: 10.1161/CIR.0000000000000625 June 18/25, 2019 e1085CLINICAL STATEMENTS AND GUIDELINESmembers volunteer their time to what?. ### Response: writ-ing and review efforts.


Instruction: What is CVD?

Output: cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CVD?. ### Response: cardiovascular disease.


Instruction: What is the focus of the guidelines?

Output: medical practice in the United States

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the focus of the guidelines?. ### Response: medical practice in the United States.


Instruction: Where are the guidelines relevant to patients?

Output: throughout the world

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are the guidelines relevant to patients?. ### Response: throughout the world.


Instruction: What are guidelines intended to define?

Output: practices meeting the needs of patients in most, but not all, circumstances

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are guidelines intended to define?. ### Response: practices meeting the needs of patients in most, but not all, circumstances.


Instruction: What should not re-place clinical judgment?

Output: Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not re-place clinical judgment?. ### Response: Guidelines.


Instruction: What are effective only when followed by both practitioners and patients?

Output: Recommendations for guideline-directed manage-ment and therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are effective only when followed by both practitioners and patients?. ### Response: Recommendations for guideline-directed manage-ment and therapy.


Instruction: Adherence to recommendations can be enhanced by sharing what?

Output: decision-making

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Adherence to recommendations can be enhanced by sharing what?. ### Response: decision-making.


Instruction: Patients engagement in selecting interventions on the basis of individual values, preferences, and associated condi-tions?

Output: practitioners and patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients engagement in selecting interventions on the basis of individual values, preferences, and associated condi-tions?. ### Response: practitioners and patients.


Instruction: The ACC/AHA Task Force on Clinical Practice Guidelines strives to ensure that the guideline writ-ing committee contains what?

Output: requisite expertise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The ACC/AHA Task Force on Clinical Practice Guidelines strives to ensure that the guideline writ-ing committee contains what?. ### Response: requisite expertise.


Instruction: What do the ACC and AHA have rigorous policies and methods to ensure?

Output: documents are developed without bias or improper influence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do the ACC and AHA have rigorous policies and methods to ensure?. ### Response: documents are developed without bias or improper influence.


Instruction: What do they invite organizations and professional societies with related interests and ex-pertise to do?

Output: participate as partners or collaborators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do they invite organizations and professional societies with related interests and ex-pertise to do?. ### Response: participate as partners or collaborators.


Instruction: ACC and AHA have rigorous policies and methods to ensure that documents are developed without what?

Output: bias or improper influence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ACC and AHA have rigorous policies and methods to ensure that documents are developed without what?. ### Response: bias or improper influence.


Instruction: Where can the complete policy on relation-ships with industry and other entities be found?

Output: online

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can the complete policy on relation-ships with industry and other entities be found?. ### Response: online.


Instruction: What has been and continues to be implemented to make guidelines shorter and enhance “user friendli-ness”?

Output: numerous modifications to the guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been and continues to be implemented to make guidelines shorter and enhance “user friendli-ness”?. ### Response: numerous modifications to the guidelines.


Instruction: Guidelines are written and presented in what format?

Output: modu-lar knowledge chunk format

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Guidelines are written and presented in what format?. ### Response: modu-lar knowledge chunk format.


Instruction: What is provided for each modular knowl-edge chunk to facilitate quick access and review?

Output: Hyper -linked references

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is provided for each modular knowl-edge chunk to facilitate quick access and review?. ### Response: Hyper -linked references.


Instruction: What does tar-gets stand for?

Output: word limits

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does tar-gets stand for?. ### Response: word limits.


Instruction: How many more structured guidelines are there?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many more structured guidelines are there?. ### Response: 2.


Instruction: What is the abbreviation of the Preamble?

Output: abbreviated version

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the abbreviation of the Preamble?. ### Response: abbreviated version.


Instruction: Who is a member of the ACC/AHA Task Force on Clinical Practice Guidelines?

Output: Glenn N. Levine, MD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a member of the ACC/AHA Task Force on Clinical Practice Guidelines?. ### Response: Glenn N. Levine, MD.


Instruction: What is a systematic review and meta-analysis?

Output: Isometric exercise training for blood pressure management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a systematic review and meta-analysis?. ### Response: Isometric exercise training for blood pressure management.


Instruction: What is the name of the study that investigated the effect of aerobic exercise on blood pressure?

Output: Whelton SP , Chin A, Xin X, et al. Effect of aerobic exercise on blood pressure: a meta-analysis of randomized, controlled trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the effect of aerobic exercise on blood pressure?. ### Response: Whelton SP , Chin A, Xin X, et al. Effect of aerobic exercise on blood pressure: a meta-analysis of randomized, controlled trials.


Instruction: What isometric exercise training for blood pressure management?

Output: a systematic review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What isometric exercise training for blood pressure management?. ### Response: a systematic review.


Instruction: What is the name of the systematic review and meta-analysis?

Output: Isometric exercise training for blood pressure management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta-analysis?. ### Response: Isometric exercise training for blood pressure management.


Instruction: What does each modular chunk include?

Output: a table of related recommendations, a brief synopsis, recommenda-tion-specific supportive text and, when appropriate, flow diagrams or additional tables

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does each modular chunk include?. ### Response: a table of related recommendations, a brief synopsis, recommenda-tion-specific supportive text and, when appropriate, flow diagrams or additional tables.


Instruction: What is provided within the modular chunk itself to facilitate quick review?

Output: References

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is provided within the modular chunk itself to facilitate quick review?. ### Response: References.


Instruction: What will facilitate seamless updating of guide-lines with focused updates as new evidence is published?

Output: chunk format

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will facilitate seamless updating of guide-lines with focused updates as new evidence is published?. ### Response: chunk format.


Instruction: What was instituted when this guideline was near completion?

Output: -mat

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was instituted when this guideline was near completion?. ### Response: -mat.


Instruction: What does the current document represent that best suits the text as written?

Output: transi-tional formatting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the current document represent that best suits the text as written?. ### Response: transi-tional formatting.


Instruction: Future guidelines will fully implement what format?

Output: chunk format

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Future guidelines will fully implement what format?. ### Response: chunk format.


Instruction: What may be performed in certain guidelines in accordance with the ACC/AHA methodology?

Output: an analysis of the value of a medication, device, or intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be performed in certain guidelines in accordance with the ACC/AHA methodology?. ### Response: an analysis of the value of a medication, device, or intervention.


Instruction: What is reviewed on an ongoing basis to ensure that guideline recommendations remain current?

Output: new data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reviewed on an ongoing basis to ensure that guideline recommendations remain current?. ### Response: new data.


Instruction: How many years are full guideline revisions commissioned?

Output: 6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many years are full guideline revisions commissioned?. ### Response: 6.


Instruction: What will prompt evaluation by the Task Force?

Output: Publication of new, potentially practice-changing study results

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will prompt evaluation by the Task Force?. ### Response: Publication of new, potentially practice-changing study results.


Instruction: Who will evaluate new, potentially practice-changing study results?

Output: the Task Force

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who will evaluate new, potentially practice-changing study results?. ### Response: the Task Force.


Instruction: Who determines whether a focused update should be commissioned?

Output: the Task Force

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who determines whether a focused update should be commissioned?. ### Response: the Task Force.


Instruction: What does the Task Force strive to avoid by selecting experts from?

Output: bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Task Force strive to avoid by selecting experts from?. ### Response: bias.


Instruction: What does the Task Force try to avoid by selecting experts from a broad array of backgrounds?

Output: bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Task Force try to avoid by selecting experts from a broad array of backgrounds?. ### Response: bias.


Instruction: What do writing commit-tee members represent different geographic regions, sexes, ethnicities, races, intellectual perspectives/biases and scopes of clinical practice?

Output: experts from a broad array of backgrounds

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do writing commit-tee members represent different geographic regions, sexes, ethnicities, races, intellectual perspectives/biases and scopes of clinical practice?. ### Response: experts from a broad array of backgrounds.


Instruction: What are professional societies with re-lated interests and expertise to participate as partners, collaborators, or endorsers?

Output: The Task Force

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are professional societies with re-lated interests and expertise to participate as partners, collaborators, or endorsers?. ### Response: The Task Force.


Instruction: What do ACC and AHA have rigorous policies and methods to ensure?

Output: guidelines are developed without bias or improper influence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do ACC and AHA have rigorous policies and methods to ensure?. ### Response: guidelines are developed without bias or improper influence.


Instruction: What is a relationship with industry and other entities (RWI) policy?

Output: rigorous policies and methods to ensure that guidelines are developed without bias or improper influence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a relationship with industry and other entities (RWI) policy?. ### Response: rigorous policies and methods to ensure that guidelines are developed without bias or improper influence.


Instruction: When was the RWI policy downloaded?

Output: April 23, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the RWI policy downloaded?. ### Response: April 23, 2023.


Instruction: What is the name of the book that treats heart failure chronic heart failure?

Output: Treating Heart Failure  Chronic Heart Failure  © NICE 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the book that treats heart failure chronic heart failure?. ### Response: Treating Heart Failure  Chronic Heart Failure  © NICE 2018.


Instruction: Who is the author of NICE 2018?

Output: Gutzwiller

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of NICE 2018?. ### Response: Gutzwiller.


Instruction: What are the limitations of FAIR -HF RCT 17-18, 72, 118, 139, and 269?

Output: Potentially serious limitations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the limitations of FAIR -HF RCT 17-18, 72, 118, 139, and 269?. ### Response: Potentially serious limitations.


Instruction: What is the effect of Incremental cost on Cost -effectiveness Gutzwiller 2012 140

Output: Incremental effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of Incremental cost on Cost -effectiveness Gutzwiller 2012 140. ### Response: Incremental effects.


Instruction: How much iron was repletion with ferric carboxymaltose IV bolus injection cost?

Output: £149

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much iron was repletion with ferric carboxymaltose IV bolus injection cost?. ### Response: £149.


Instruction: How much per QALY gained Probability Intervention 2 cost -effective (£20K/30K threshold)?

Output: £3,977

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much per QALY gained Probability Intervention 2 cost -effective (£20K/30K threshold)?. ### Response: £3,977.


Instruction: What was the cost-effectiveness of Intervention 2?

Output: 99.66%/99.68 %

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the cost-effectiveness of Intervention 2?. ### Response: 99.66%/99.68 %.


Instruction: What were the most influential parameters?

Output: Frequency and duration of hospitalisation, QALY difference, and cost of hospital day

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the most influential parameters?. ### Response: Frequency and duration of hospitalisation, QALY difference, and cost of hospital day.


Instruction: None of the parameters tested resulted in an ICER above what?

Output: £20,000 per QA LY gained

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: None of the parameters tested resulted in an ICER above what?. ### Response: £20,000 per QA LY gained.


Instruction: How much does ICER cost per QA LY gained?

Output: £20,000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much does ICER cost per QA LY gained?. ### Response: £20,000.


Instruction: What does QALY stand for?

Output: quality -adjusted life years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does QALY stand for?. ### Response: quality -adjusted life years.


Instruction: Where was the FAIR -HF trial performed?

Output: European countries with a predominantly Caucasian population

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where was the FAIR -HF trial performed?. ### Response: European countries with a predominantly Caucasian population.


Instruction: What is unlikely to change the conclusions of cost -effectiveness?

Output: The FAIR -HF trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is unlikely to change the conclusions of cost -effectiveness?. ### Response: The FAIR -HF trial.


Instruction: What may not capture full costs and effects of the intervention?

Output: Short time horizon

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may not capture full costs and effects of the intervention?. ### Response: Short time horizon.


Instruction: FAIR -HF is one of how many studies comparing IV iron to what treatment?

Output: 4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: FAIR -HF is one of how many studies comparing IV iron to what treatment?. ### Response: 4.


Instruction: Who published the 2018 Cholesterol Clinical Practice GuidelinesCirculation. 2019;139:e1082–e1143. DOI: 10.1161/CIR.0000000000000625 June 18/25, 2019 e1083CLINICAL STATEMENTS AND GUIDELINESTABLE OF CONTENTSTop 10 Take-Home Messages to Reduce Risk of Atherosclerotic Cardiovascular Disease Through Cholestrol Management?

Output: Grundy et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2018 Cholesterol Clinical Practice GuidelinesCirculation. 2019;139:e1082–e1143. DOI: 10.1161/CIR.0000000000000625 June 18/25, 2019 e1083CLINICAL STATEMENTS AND GUIDELINESTABLE OF CONTENTSTop 10 Take-Home Messages to Reduce Risk of Atherosclerotic Cardiovascular Disease Through Cholestrol Management?. ### Response: Grundy et al.


Instruction: What is the scope of the guideline?

Output: Class of Recommendation and Level  of Evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the scope of the guideline?. ### Response: Class of Recommendation and Level  of Evidence.


Instruction: What are the abbreviations for High Blood Cholesterol and ASCVD?

Output: e10872

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the abbreviations for High Blood Cholesterol and ASCVD?. ### Response: e10872.


Instruction: Blood Cholesterol and ASCVD............ e10872.1. What is the name of the test that measures LDL-C and Non-HDL-C?

Output: Serum Cholesterol, Lipoproteins, and ASCVD ..e10872.1.1. Cholesterol, Lipoproteins, and  Apolipoprotein B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Blood Cholesterol and ASCVD............ e10872.1. What is the name of the test that measures LDL-C and Non-HDL-C?. ### Response: Serum Cholesterol, Lipoproteins, and ASCVD ..e10872.1.1. Cholesterol, Lipoproteins, and  Apolipoprotein B.


Instruction: Apolipoprotein B and Lipoprotein (a).................... e10872.1.1.

Output: Serum Cholesterol, Lipoproteins, and ASCVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Apolipoprotein B and Lipoprotein (a).................... e10872.1.1.. ### Response: Serum Cholesterol, Lipoproteins, and ASCVD.


Instruction: What is a measure of Apolipoprotein B and Lipoprotein (a)?

Output: LDL-C and Non–HDL-C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a measure of Apolipoprotein B and Lipoprotein (a)?. ### Response: LDL-C and Non–HDL-C.


Instruction: Monitoring Response of LDL-C to Statin Therapy?

Output: e10903

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Monitoring Response of LDL-C to Statin Therapy?. ### Response: e10903.


Instruction: What are Lifestyle Therapies and Metabolic Syndrome?

Output: Diet Composition, Weight Control,  and Physical Activity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are Lifestyle Therapies and Metabolic Syndrome?. ### Response: Diet Composition, Weight Control,  and Physical Activity.


Instruction: What is a Metabolic Syndrome?

Output: Lifestyle Therapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a Metabolic Syndrome?. ### Response: Lifestyle Therapies.


Instruction: What are Lipid-Lowering Drugs?

Output: Therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are Lipid-Lowering Drugs?. ### Response: Therapy.


Instruction: Statin Therapy is an example of what?

Output: Lipid-Lowering Drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Statin Therapy is an example of what?. ### Response: Lipid-Lowering Drugs.


Instruction: Nonstatin Add-on Drugs to Statin Therapies are examples of what kind of therapy?

Output: Statin Therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Nonstatin Add-on Drugs to Statin Therapies are examples of what kind of therapy?. ### Response: Statin Therapy.


Instruction: How many mg/dL does a person with diabetes have?

Output: ≥190

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mg/dL does a person with diabetes have?. ### Response: ≥190.


Instruction: How many mmol/l is diabetes in adults?

Output: 4.9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mmol/l is diabetes in adults?. ### Response: 4.9.


Instruction: What is the primary prevention for adults with diabetes?

Output: Evaluation and Risk Assessment ..... e10994.4.2. Primary Prevention Adults 40 to  75 Years of Age With LDL-C Levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary prevention for adults with diabetes?. ### Response: Evaluation and Risk Assessment ..... e10994.4.2. Primary Prevention Adults 40 to  75 Years of Age With LDL-C Levels.


Instruction: What is the range of mg/dL?

Output: ≥190

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the range of mg/dL?. ### Response: ≥190.


Instruction: What is a primary prevention in other age groups?

Output: LDL-C Levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a primary prevention in other age groups?. ### Response: LDL-C Levels.


Instruction: How is hypertriglyceridemia treated?

Output: Implementation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is hypertriglyceridemia treated?. ### Response: Implementation.


Instruction: What is a side effect of PCSK9?

Output: Economic Value Considerations:  PCSK9 Inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a side effect of PCSK9?. ### Response: Economic Value Considerations:  PCSK9 Inhibitors.


Instruction: What is an economic value consideration?

Output: PCSK9 Inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an economic value consideration?. ### Response: PCSK9 Inhibitors.


Instruction: e11228.1. Randomized Controlled Trials.............................................................

Output: e1122

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: e11228.1. Randomized Controlled Trials.............................................................. ### Response: e1122.


Instruction: What did the committee discuss the breakdown of?

Output: costs and QALYs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee discuss the breakdown of?. ### Response: costs and QALYs.


Instruction: What was the committees previous statement?

Output: sensitivity is the most critical outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the committees previous statement?. ### Response: sensitivity is the most critical outcome.


Instruction: What is the most critical outcome of the test?

Output: sensitivity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most critical outcome of the test?. ### Response: sensitivity.


Instruction: What does the model suggest is most critical with regards to cost effectiveness?

Output: specificity of the test

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the model suggest is most critical with regards to cost effectiveness?. ### Response: specificity of the test.


Instruction: The model is driven by what?

Output: greater cost reducti ons and QALY benefits of diagnosing other conditions in the non -heart failure population earlier

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The model is driven by what?. ### Response: greater cost reducti ons and QALY benefits of diagnosing other conditions in the non -heart failure population earlier.


Instruction: What is driven by the greater cost reductions and QALY benefits of diagnosing other conditions in the non -heart failure population earlier?

Output: limited QALY gains from early treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is driven by the greater cost reductions and QALY benefits of diagnosing other conditions in the non -heart failure population earlier?. ### Response: limited QALY gains from early treatment.


Instruction: What is the committee noted that the QAlys accrued for the heart failure population are?

Output: very similar

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the committee noted that the QAlys accrued for the heart failure population are?. ### Response: very similar.


Instruction: What are the QALYs for the heart failure population similar across all of the strategies?

Output: difference of 0.01 QALYs between the 400pg/ml threshold

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the QALYs for the heart failure population similar across all of the strategies?. ### Response: difference of 0.01 QALYs between the 400pg/ml threshold.


Instruction: What is the difference of 0.01 QAlys between the 400pg/ml threshold and referring all patients for echocardiography?

Output: lowest QALYs for people with heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference of 0.01 QAlys between the 400pg/ml threshold and referring all patients for echocardiography?. ### Response: lowest QALYs for people with heart failure.


Instruction: What was reassured to know that the difference was so small?

Output: T he committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was reassured to know that the difference was so small?. ### Response: T he committee.


Instruction: What is likely to be due to the low proportion of people with HF -REF in the model?

Output: small difference

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is likely to be due to the low proportion of people with HF -REF in the model?. ### Response: small difference.


Instruction: What was the most appropriate study for the base case analysis?

Output: REFER

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the most appropriate study for the base case analysis?. ### Response: REFER.


Instruction: What was concerned about the small proportion of HF-REF patients in the study?

Output: the committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was concerned about the small proportion of HF-REF patients in the study?. ### Response: the committee.


Instruction: How many HF -REF patients were in the study population?

Output: very small proportion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many HF -REF patients were in the study population?. ### Response: very small proportion.


Instruction: Why were patients with severe symptoms not recruited into these types of studies?

Output: concern that there would be a delay in their treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why were patients with severe symptoms not recruited into these types of studies?. ### Response: concern that there would be a delay in their treatment.


Instruction: Why were patients recruited into clinical studies?

Output: greater cost reducti ons and QALY benefits of diagnosing other conditions in the non -heart failure population earlier

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why were patients recruited into clinical studies?. ### Response: greater cost reducti ons and QALY benefits of diagnosing other conditions in the non -heart failure population earlier.


Instruction: What is more likely to have HF -REF than HF-PEF?

Output: to be of high risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more likely to have HF -REF than HF-PEF?. ### Response: to be of high risk.


Instruction: The extent of possible selection bias is what?

Output: unknown

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The extent of possible selection bias is what?. ### Response: unknown.


Instruction: What is unknown about the extent of possible selection bias?

Output: the extent of possible selection bias is unknown.   Due to uncertainty around the diagnostic accuracy of the NT -proBNP test

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is unknown about the extent of possible selection bias?. ### Response: the extent of possible selection bias is unknown.   Due to uncertainty around the diagnostic accuracy of the NT -proBNP test.


Instruction: Why were two scenario analyses undertaken to assess the diagnostic accuracy data?

Output: uncertainty around the diagnostic accuracy of the NT -proBNP test

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why were two scenario analyses undertaken to assess the diagnostic accuracy data?. ### Response: uncertainty around the diagnostic accuracy of the NT -proBNP test.


Instruction: What was not consistent with the reported study values?

Output: mean sensitivity values

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not consistent with the reported study values?. ### Response: mean sensitivity values.


Instruction: What model was applied to the Verdu data to enable the results to be ru n probabilistically?

Output: ordinal logistic regression model

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What model was applied to the Verdu data to enable the results to be ru n probabilistically?. ### Response: ordinal logistic regression model.


Instruction: What were not consistent with the reported study values?

Output: mean sensitivity values

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were not consistent with the reported study values?. ### Response: mean sensitivity values.


Instruction: What was run both probabilistically and deterministically?

Output: Verdu study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was run both probabilistically and deterministically?. ### Response: Verdu study.


Instruction: What was the most suitable method to fit a distribution?

Output: REFER study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the most suitable method to fit a distribution?. ### Response: REFER study.


Instruction: What was thought to be due to the fact that the sensitivity of 280pg/ml was 100%?

Output: The inconsistency in the mean values

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was thought to be due to the fact that the sensitivity of 280pg/ml was 100%?. ### Response: The inconsistency in the mean values.


Instruction: What is the 2015 ACC/AHA/HRS SVT Guideline e5172.4.2?

Output: Ongoing Management: RecommendationsThe recommendations and algorithm (Figure 9) for ongoing management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2015 ACC/AHA/HRS SVT Guideline e5172.4.2?. ### Response: Ongoing Management: RecommendationsThe recommendations and algorithm (Figure 9) for ongoing management.


Instruction: What are the recommendations and algorithm meant to include?

Output: consideration of patient preferences and clinical judgment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the recommendations and algorithm meant to include?. ### Response: consideration of patient preferences and clinical judgment.


Instruction: What may include consultation with a car-diologist or clinical cardiac electrophyisiologist?

Output: Ongoing Management: RecommendationsThe recommendations and algorithm (Figure 9) for ongoing management, along with other recommendations and algo-rithms for specific SVTs that follow, are meant to include consideration of patient preferences and clinical judgment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may include consultation with a car-diologist or clinical cardiac electrophyisiologist?. ### Response: Ongoing Management: RecommendationsThe recommendations and algorithm (Figure 9) for ongoing management, along with other recommendations and algo-rithms for specific SVTs that follow, are meant to include consideration of patient preferences and clinical judgment.


Instruction: What must be considered in the context of frequency and dura-tion of treatment?

Output: Recommendations for treatment options

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must be considered in the context of frequency and dura-tion of treatment?. ### Response: Recommendations for treatment options.


Instruction: What should be considered in the context of frequency and dura-tion of the SVT?

Output: Recommendations for treatment options

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered in the context of frequency and dura-tion of the SVT?. ### Response: Recommendations for treatment options.


Instruction: What is useful for ongoing management of SVT of Unknown Mechanism?

Output: Oral beta blockers, diltiazem, or verapamil

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is useful for ongoing management of SVT of Unknown Mechanism?. ### Response: Oral beta blockers, diltiazem, or verapamil.


Instruction: What is useful for ongoing management in patients with symptomatic SVT?

Output: Oral beta blockers, diltiazem, or verapamil

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is useful for ongoing management in patients with symptomatic SVT?. ### Response: Oral beta blockers, diltiazem, or verapamil.


Instruction: What does blockers, diltiazem, or verapamil not have?

Output: ventricular pre-excitation during sinus rhythm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does blockers, diltiazem, or verapamil not have?. ### Response: ventricular pre-excitation during sinus rhythm.


Instruction: What may be mandatory therapy for certain occupations?

Output: ablation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be mandatory therapy for certain occupations?. ### Response: ablation.


Instruction: What may patients prefer not to undergo ablation or may not have access to a cardiac electrophysiologist?

Output: pharmacological therapy with AV nodal blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may patients prefer not to undergo ablation or may not have access to a cardiac electrophysiologist?. ### Response: pharmacological therapy with AV nodal blockers.


Instruction: What is an appropriate option for long-term prophylactic therapy?

Output: pharmacological therapy with AV nodal blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an appropriate option for long-term prophylactic therapy?. ### Response: pharmacological therapy with AV nodal blockers.


Instruction: What has been studied in RCTs with pharmacological therapy with verapamil?

Output: reductions documented in SVT episode frequency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been studied in RCTs with pharmacological therapy with verapamil?. ### Response: reductions documented in SVT episode frequency.


Instruction: What is evidence for beta blockers limited to?

Output: 98

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is evidence for beta blockers limited to?. ### Response: 98.


Instruction: What is one small study that randomized patients with SVT to digoxin or propranolol?

Output: beta blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one small study that randomized patients with SVT to digoxin or propranolol?. ### Response: beta blockers.


Instruction: How many weeks of placebo washout between drug regimens?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many weeks of placebo washout between drug regimens?. ### Response: 1.


Instruction: How was the reduction in the number of episodes and duration of SVT determined?

Output: diary and weekly 24-h Holter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the reduction in the number of episodes and duration of SVT determined?. ### Response: diary and weekly 24-h Holter.


Instruction: How were all 3 medications well tolerated?

Output: Reduction in the number of episodes and duration of SVT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How were all 3 medications well tolerated?. ### Response: Reduction in the number of episodes and duration of SVT.


Instruction: What option is useful for the diagnosis and potential treatment of the SVT?

Output: ablation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What option is useful for the diagnosis and potential treatment of the SVT?. ### Response: ablation.


Instruction: What is useful for the diagnosis and potential treatment of SVT?

Output: EP study with the option of ablation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is useful for the diagnosis and potential treatment of SVT?. ### Response: EP study with the option of ablation.


Instruction: What does EP testing with the option of ablation provide as first-line therapy for treatment of?

Output: symptomatic SVT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does EP testing with the option of ablation provide as first-line therapy for treatment of?. ### Response: symptomatic SVT.


Instruction: Large registry studies report what?

Output: high success rates for ablation of both AVNRT and AVRT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Large registry studies report what?. ### Response: high success rates for ablation of both AVNRT and AVRT.


Instruction: What is the need for chronic pharmacological therapy?

Output: reductions documented in SVT episode frequency and duration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the need for chronic pharmacological therapy?. ### Response: reductions documented in SVT episode frequency and duration.


Instruction: Large registry studies report high success rates for ablation of both AVNRT and AVRT with low frequency of potentially serious complications?

Output: Table 8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Large registry studies report high success rates for ablation of both AVNRT and AVRT with low frequency of potentially serious complications?. ### Response: Table 8.


Instruction: Patients with SVT should be educated on how to perform what?

Output: vagal maneuvers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with SVT should be educated on how to perform what?. ### Response: vagal maneuvers.


Instruction: What can achieve similar outcome as thrombolysis by neurologist on-site?

Output: Telephone and teleradiology-guided thrombolysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can achieve similar outcome as thrombolysis by neurologist on-site?. ### Response: Telephone and teleradiology-guided thrombolysis.


Instruction: What year did J Stroke Cerebrovasc Dis. 2015;24:1223-1228?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did J Stroke Cerebrovasc Dis. 2015;24:1223-1228?. ### Response: 2015.


Instruction: What is the name of the surgery performed on-site?

Output: thrombolysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the surgery performed on-site?. ### Response: thrombolysis.


Instruction: What are the training standards in neu-roendovascular surgery?

Output: program accreditation and practitioner certifica-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the training standards in neu-roendovascular surgery?. ### Response: program accreditation and practitioner certifica-tion.


Instruction: How many strokes were treated with computed tomographic perfusion and angiograms from 2006 to 2010?

Output: acute ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes were treated with computed tomographic perfusion and angiograms from 2006 to 2010?. ### Response: acute ischemic stroke.


Instruction: What is the name of the study that investigated the economic benefit of increasing uti-lization of intravenous catheters?

Output: German Stroke Registers Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the economic benefit of increasing uti-lization of intravenous catheters?. ### Response: German Stroke Registers Study Group.


Instruction: What is the economic benefit of increasing uti-lization of intravenous tissue plasminogen activator for acute is-chemic stroke in the United States?

Output: improvement in door-to-needle time

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the economic benefit of increasing uti-lization of intravenous tissue plasminogen activator for acute is-chemic stroke in the United States?. ### Response: improvement in door-to-needle time.


Instruction: How does diagnosis-related group 559 change the US Medicare cost reimbursement ratio for stroke centers?

Output: 64

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does diagnosis-related group 559 change the US Medicare cost reimbursement ratio for stroke centers?. ### Response: 64.


Instruction: What is the reimbursement ratio for stroke centers?

Output: US Medicare cost

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the reimbursement ratio for stroke centers?. ### Response: US Medicare cost.


Instruction: What was Stroke. 2007;38:1309-1312. doi: 10.1161/01.STR.0000260185.74694.a7 65

Output: How diagnosis-related group 559 will change the US Medicare cost reimbursement ratio for stroke centers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was Stroke. 2007;38:1309-1312. doi: 10.1161/01.STR.0000260185.74694.a7 65. ### Response: How diagnosis-related group 559 will change the US Medicare cost reimbursement ratio for stroke centers.


Instruction: What does Leadership in Applied Health Research and Care Investigators do?

Output: Cost-effectiveness of optimizing acute stroke care services for thrombolysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Leadership in Applied Health Research and Care Investigators do?. ### Response: Cost-effectiveness of optimizing acute stroke care services for thrombolysis.


Instruction: What is the cost-effectiveness of optimizing acute stroke care services for thrombolysis?

Output: similar outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cost-effectiveness of optimizing acute stroke care services for thrombolysis?. ### Response: similar outcome.


Instruction: Stroke. 2014;45:553–562. doi: 10.1161/STROKEAHA.113.003216 66.

Output: Cost-effectiveness of optimizing acute stroke care services for thrombolysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Stroke. 2014;45:553–562. doi: 10.1161/STROKEAHA.113.003216 66.. ### Response: Cost-effectiveness of optimizing acute stroke care services for thrombolysis.


Instruction: How many hours of acute ischemic stroke did an Australian stroke center experience?

Output: 4.5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many hours of acute ischemic stroke did an Australian stroke center experience?. ### Response: 4.5.


Instruction: What year did Stroke.44:2269–2274.

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Stroke.44:2269–2274.. ### Response: 2013.


Instruction: What is the doi: 10.1161/STROKEAHA.113.001295?

Output: 67

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the doi: 10.1161/STROKEAHA.113.001295?. ### Response: 67.


Instruction: Who assessed mechanical thrombectomy in acute stroke patients?

Output: Health Quality Ontario

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who assessed mechanical thrombectomy in acute stroke patients?. ### Response: Health Quality Ontario.


Instruction: What is a cost-utility analysis of mechanical thrombectomy using stent retrievers in acute ischemic stroke?

Output: Ganesalingam J, Pizzo E, Morris S, Sunderland T, Ames D, Lobotesis K. Cost-utility analysis of mechanical thrombectomy using stent retrievers in acute ischemic stroke. Stroke. 2015;46:2591–2598

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a cost-utility analysis of mechanical thrombectomy using stent retrievers in acute ischemic stroke?. ### Response: Ganesalingam J, Pizzo E, Morris S, Sunderland T, Ames D, Lobotesis K. Cost-utility analysis of mechanical thrombectomy using stent retrievers in acute ischemic stroke. Stroke. 2015;46:2591–2598.


Instruction: What is the doi: 10.1161/STROKEAHA.115.00939668a?

Output: 66

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the doi: 10.1161/STROKEAHA.115.00939668a?. ### Response: 66.


Instruction: What year did Paul Coverdell National Acute Stroke Program Team report a decade of improvement in door-to-needle time among acute is-chemic stroke patients?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Paul Coverdell National Acute Stroke Program Team report a decade of improvement in door-to-needle time among acute is-chemic stroke patients?. ### Response: 2008.


Instruction: What is the name of the study that examined the improvement from 2008 to 2017?

Output: German Stroke Registers Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined the improvement from 2008 to 2017?. ### Response: German Stroke Registers Study Group.


Instruction: How long did it take for patients with acute stroke to improve their door to needle time?

Output: decade

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for patients with acute stroke to improve their door to needle time?. ### Response: decade.


Instruction: Who is the author of Circ Cardiovasc Qual Outcomes?

Output: CIRCOUTCOMES

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of Circ Cardiovasc Qual Outcomes?. ### Response: CIRCOUTCOMES.


Instruction: What is the name of the study group that studies the quality of stroke care?

Output: German Stroke Registers Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study group that studies the quality of stroke care?. ### Response: German Stroke Registers Study Group.


Instruction: How many stroke patients have been evaluated?

Output: 260 000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many stroke patients have been evaluated?. ### Response: 260 000.


Instruction: What type of care is provided to stroke patients?

Output: Mechanical thrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of care is provided to stroke patients?. ### Response: Mechanical thrombectomy.


Instruction: What do medical examiners need to be able to harvest for DNA testing?

Output: standards

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do medical examiners need to be able to harvest for DNA testing?. ### Response: standards.


Instruction: What do hos-pital pathologists and private pathologists need standards for?

Output: harvesting and storing samples for later genetic testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do hos-pital pathologists and private pathologists need standards for?. ### Response: harvesting and storing samples for later genetic testing.


Instruction: How long did it take for family members of SCD probands to last seen alive and well?

Output: 12 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for family members of SCD probands to last seen alive and well?. ### Response: 12 hours.


Instruction: What were autopsy findings showing?

Output: structural abnormalities of uncertain significance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were autopsy findings showing?. ### Response: structural abnormalities of uncertain significance.


Instruction: How many people died suddenly?

Output: 41

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people died suddenly?. ### Response: 41.


Instruction: What was the prevalence of genetic variants associated with sudden arrhythmic deaths?

Output: 51%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the prevalence of genetic variants associated with sudden arrhythmic deaths?. ### Response: 51%.


Instruction: What percentage of ventricular hypertrophy, myocardial fibrosis, or minor ischemic heart disease had a prevalence?

Output: 51%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of ventricular hypertrophy, myocardial fibrosis, or minor ischemic heart disease had a prevalence?. ### Response: 51%.


Instruction: What can facilitate family screening?

Output: Identification of the genotype

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can facilitate family screening?. ### Response: Identification of the genotype.


Instruction: What should patients be informed about at the time of ICD implantation or replacement?

Output: their ICD shock therapy can be deactivated at any time if it is consistent with their goals and preferences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients be informed about at the time of ICD implantation or replacement?. ### Response: their ICD shock therapy can be deactivated at any time if it is consistent with their goals and preferences.


Instruction: What can be deactivated at any time if it is consistent with their goals and preferences?

Output: ICD shock therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be deactivated at any time if it is consistent with their goals and preferences?. ### Response: ICD shock therapy.


Instruction: What should clinicians discuss with patients with refractory HF symptoms?

Output: ICD shock deactivation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should clinicians discuss with patients with refractory HF symptoms?. ### Response: ICD shock deactivation.


Instruction: What should clinicians discuss with patients about ICD shock deactivation?

Output: consider the patients’ goals and preferences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should clinicians discuss with patients about ICD shock deactivation?. ### Response: consider the patients’ goals and preferences.


Instruction: What is a particularly challenging area of medicine?

Output: recogniz-ing when life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a particularly challenging area of medicine?. ### Response: recogniz-ing when life.


Instruction: When life-prolonging therapies may become what?

Output: bur -densome or even harmful

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When life-prolonging therapies may become what?. ### Response: bur -densome or even harmful.


Instruction: What may cause unnecessary morbidity and distress to both patients and loved ones?

Output: life-prolonging shocks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may cause unnecessary morbidity and distress to both patients and loved ones?. ### Response: life-prolonging shocks.


Instruction: What do clinicians not routinely inform during deci-sion-making?

Output: patients about ICD deactivation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do clinicians not routinely inform during deci-sion-making?. ### Response: patients about ICD deactivation.


Instruction: What do clinicians not routinely inform patients about?

Output: ICD deactivation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do clinicians not routinely inform patients about?. ### Response: ICD deactivation.


Instruction: What do patients often not include in advance care planning documents?

Output: wishes about deactivation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do patients often not include in advance care planning documents?. ### Response: wishes about deactivation.


Instruction: What does not include wishes about deactivation in advance care planning documents?

Output: patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not include wishes about deactivation in advance care planning documents?. ### Response: patients.


Instruction: What do surrogates usually make decisions about?

Output: ICD deactivation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do surrogates usually make decisions about?. ### Response: ICD deactivation.


Instruction: Patients with ICDs were able to identify scenarios in which they might choose to deactivate what?

Output: ICD shock therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with ICDs were able to identify scenarios in which they might choose to deactivate what?. ### Response: ICD shock therapy.


Instruction: What can happen at any time?

Output: This discussion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can happen at any time?. ### Response: This discussion.


Instruction: What is particularly important to have at the time of initial ICD implantation?

Output: This discussion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is particularly important to have at the time of initial ICD implantation?. ### Response: This discussion.


Instruction: When are ICDs not deactivated?

Output: at the end of life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When are ICDs not deactivated?. ### Response: at the end of life.


Instruction: When is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction?

Output: June 2020

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction?. ### Response: June 2020.


Instruction: How old is the person in the Question Set # Concept Strategy Questions 9, 10, 11, 12?

Output: 105

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old is the person in the Question Set # Concept Strategy Questions 9, 10, 11, 12?. ### Response: 105.


Instruction: What is the name of the non-pharmacologic treatment that includes cost (cont.)?

Output: quality adjusted life year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the non-pharmacologic treatment that includes cost (cont.)?. ### Response: quality adjusted life year.


Instruction: What is another name for combine sets without outcomes of interest?

Output: AND (#3 OR #4 OR #5)  #9 Limit to RCTs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for combine sets without outcomes of interest?. ### Response: AND (#3 OR #4 OR #5)  #9 Limit to RCTs.


Instruction: How many RCTs are limit to?

Output: #9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs are limit to?. ### Response: #9.


Instruction: #10 Limit to SRs/Meta -analysis Systematic review/meta-analysis hedge [see Search Limits at the end of this table] #11 Limit to cost studies (KQ 9)

Output: Limit to meta -analyses and SRs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: #10 Limit to SRs/Meta -analysis Systematic review/meta-analysis hedge [see Search Limits at the end of this table] #11 Limit to cost studies (KQ 9). ### Response: Limit to meta -analyses and SRs.


Instruction: What is an example of an economic evaluation?

Output: quality adjusted life year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of an economic evaluation?. ### Response: quality adjusted life year.


Instruction: What is a cost effectiveness analysis?

Output: cost benefit analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a cost effectiveness analysis?. ### Response: cost benefit analysis.


Instruction: What is the name of the QALY?

Output: QALYs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the QALY?. ### Response: QALYs.


Instruction: What is another name for quality NEXT/1 adjusted life next/1 expectanc*?

Output: ):ti,ab

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for quality NEXT/1 adjusted life next/1 expectanc*?. ### Response: ):ti,ab.


Instruction: How many sets of search limits are there?

Output: #12

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many sets of search limits are there?. ### Response: #12.


Instruction: What are the search limits applied to?

Output: Each Search

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the search limits applied to?. ### Response: Each Search.


Instruction: How many searches were conducted in 2014?

Output: December 9, 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many searches were conducted in 2014?. ### Response: December 9, 2013.


Instruction: What excludes conference publications, books, letters, editorials, case studies, etc?

Output: abstract:nc

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What excludes conference publications, books, letters, editorials, case studies, etc?. ### Response: abstract:nc.


Instruction: What is a bstract?

Output: conference

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a bstract?. ### Response: conference.


Instruction: What is an erratum?

Output: de

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an erratum?. ### Response: de.


Instruction: Is there a limit to meta-analyses and SRs?

Output: Limit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Is there a limit to meta-analyses and SRs?. ### Response: Limit.


Instruction: What are meta -analyses and SRs?

Output: Limit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are meta -analyses and SRs?. ### Response: Limit.


Instruction: What are RCTs limited to?

Output: meta -analyses and SRs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are RCTs limited to?. ### Response: meta -analyses and SRs.


Instruction: What is latin square?

Output: OR isrtcn* OR actrn* OR (nct* NOT nct))

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is latin square?. ### Response: OR isrtcn* OR actrn* OR (nct* NOT nct)).


Instruction: What is random*?

Output: ti,de OR crossover*

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is random*?. ### Response: ti,de OR crossover*.


Instruction: What are patients who have received protamine sulfate-containing insulin at increased risk of having?

Output: preformed antibodies against protamine sulfate and to suffer from allergic reactions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients who have received protamine sulfate-containing insulin at increased risk of having?. ### Response: preformed antibodies against protamine sulfate and to suffer from allergic reactions.


Instruction: What type of reaction does anaphylaxis include?

Output: allergic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of reaction does anaphylaxis include?. ### Response: allergic.


Instruction: What is a common allergic reaction to protamine sulfate?

Output: anaphylaxis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a common allergic reaction to protamine sulfate?. ### Response: anaphylaxis.


Instruction: What can patients be pretreated with if they have concerns about a potential allergy?

Output: corticoste-roids and antihistamines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can patients be pretreated with if they have concerns about a potential allergy?. ### Response: corticoste-roids and antihistamines.


Instruction: Corticosteroids and antihistamines can be used to treat what?

Output: protamine sulfate allergy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Corticosteroids and antihistamines can be used to treat what?. ### Response: protamine sulfate allergy.


Instruction: What other substance has been shown to neutralize the anticoagulant effects of UFH?

Output: hexadimethrine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What other substance has been shown to neutralize the anticoagulant effects of UFH?. ### Response: hexadimethrine.


Instruction: What is hexadimethrine?

Output: Polybrene

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hexadimethrine?. ### Response: Polybrene.


Instruction: What are 107 and synthetic protamine variants?

Output: extracorporeal heparin removal devices

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are 107 and synthetic protamine variants?. ### Response: extracorporeal heparin removal devices.


Instruction: None of these are approved for what?

Output: clinical use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: None of these are approved for what?. ### Response: clinical use.


Instruction: What are Low-Molecular-Weight Heparins derived from?

Output: UFH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are Low-Molecular-Weight Heparins derived from?. ### Response: UFH.


Instruction: What has a more favorable benefi t-to-risk ratio than heparin in animal models 112,113?

Output: 9,10,109-111

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has a more favorable benefi t-to-risk ratio than heparin in animal models 112,113?. ### Response: 9,10,109-111.


Instruction: When used to treat VTE, what has superior pharmacokinetic properties?

Output: LMWHs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When used to treat VTE, what has superior pharmacokinetic properties?. ### Response: LMWHs.


Instruction: What are LMWHs about one-third the molecular weight of?

Output: UFH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are LMWHs about one-third the molecular weight of?. ### Response: UFH.


Instruction: How many saccharide units does a LMW have?

Output: 15

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many saccharide units does a LMW have?. ### Response: 15.


Instruction: What is a range of 2,000 to 9,000?

Output: LMWHs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a range of 2,000 to 9,000?. ### Response: LMWHs.


Instruction: How many saccharide units are in the range of 2,000 to 9,000?

Output: 15

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many saccharide units are in the range of 2,000 to 9,000?. ### Response: 15.


Instruction: Where are the various LMWHs approved for use?

Output: Europe, Canada, and the United States

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are the various LMWHs approved for use?. ### Response: Europe, Canada, and the United States.


Instruction: What are the different methods of depolymerization used for?

Output: pre-pared

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the different methods of depolymerization used for?. ### Response: pre-pared.


Instruction: What are LMWHs not interchangeable on a unit-for-unit basis?

Output: these drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are LMWHs not interchangeable on a unit-for-unit basis?. ### Response: these drugs.


Instruction: What induces hypotension by promoting the activation of factor XII and the sub-sequent generation of bradykinin?

Output: oversulfated chondroitin sulfate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What induces hypotension by promoting the activation of factor XII and the sub-sequent generation of bradykinin?. ### Response: oversulfated chondroitin sulfate.


Instruction: What type of therapy can cause elevations of serum transaminases?

Output: Heparin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy can cause elevations of serum transaminases?. ### Response: Heparin therapy.


Instruction: What is usually transient and is not associated with an increase in bilirubin?

Output: The increase in transaminases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is usually transient and is not associated with an increase in bilirubin?. ### Response: The increase in transaminases.


Instruction: What are the main nonhemorrhagic side effects of heparin?

Output: HIT and osteoporosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the main nonhemorrhagic side effects of heparin?. ### Response: HIT and osteoporosis.


Instruction: What is caused by IgG subclass?

Output: HIT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is caused by IgG subclass?. ### Response: HIT.


Instruction: What are IgG subclass, heparin-dependent antibodies?

Output: anti-bodies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are IgG subclass, heparin-dependent antibodies?. ### Response: anti-bodies.


Instruction: What do these anti-bodies bind to?

Output: a conformationally modiﬁ  ed epitope

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do these anti-bodies bind to?. ### Response: a conformationally modiﬁ  ed epitope.


Instruction: What is the acronym for Task Force on Clinical Practice Guidelines?

Output: Task Force

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Task Force on Clinical Practice Guidelines?. ### Response: Task Force.


Instruction: What does Task Force use to revise guideline recommendations?

Output: recently published data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Task Force use to revise guideline recommendations?. ### Response: recently published data.


Instruction: What has been subject to rigorous, multilevel review and approval?

Output: Task Force on Clinical Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been subject to rigorous, multilevel review and approval?. ### Response: Task Force on Clinical Practice Guidelines.


Instruction: For specific focused updatecriteria and additional methodological details, please see which guideline methodology manual?

Output: ACC/AHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For specific focused updatecriteria and additional methodological details, please see which guideline methodology manual?. ### Response: ACC/AHA.


Instruction: What has changed from the Institute ofMedicine mandates?

Output: adoption of a “knowledge byte ”format

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has changed from the Institute ofMedicine mandates?. ### Response: adoption of a “knowledge byte ”format.


Instruction: What format has changed leading to adoption of a "knowledge byte"format?

Output: p r o c e s s e shave

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What format has changed leading to adoption of a "knowledge byte"format?. ### Response: p r o c e s s e shave.


Instruction: What is a benefit of using electronic search engines and other evolving tech-nology?

Output: facilitates easier access to recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a benefit of using electronic search engines and other evolving tech-nology?. ### Response: facilitates easier access to recommendations.


Instruction: What is an example of a living document that can be dynamically updated as needed?

Output: guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a living document that can be dynamically updated as needed?. ### Response: guidelines.


Instruction: Intended UsePractice guidelines provide recommendations applicable to what?

Output: topatients with or at risk of developing cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Intended UsePractice guidelines provide recommendations applicable to what?. ### Response: topatients with or at risk of developing cardiovascular disease.


Instruction: What type of guidelines provide recommendations applicable to patients with or at risk of developing cardiovascular disease?

Output: Intended UsePractice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of guidelines provide recommendations applicable to patients with or at risk of developing cardiovascular disease?. ### Response: Intended UsePractice.


Instruction: The focus of the guidelines is on what country?

Output: United States

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The focus of the guidelines is on what country?. ### Response: United States.


Instruction: What are guidelines intended to improve?

Output: quality of care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are guidelines intended to improve?. ### Response: quality of care.


Instruction: What are regulatory or payer decisions intended to do?

Output: improve quality of care in the interest of patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are regulatory or payer decisions intended to do?. ### Response: improve quality of care in the interest of patients.


Instruction: What are the Class of Recommendation and Level of Evidence derived from?

Output: independently of one anotheraccording to established criteria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Class of Recommendation and Level of Evidence derived from?. ### Response: independently of one anotheraccording to established criteria.


Instruction: What indicates the strength of recommendation?

Output: COR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates the strength of recommendation?. ### Response: COR.


Instruction: What measures the magnitude and certainty of bene fito fac li n i c a laction in proportion to risk?

Output: The COR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What measures the magnitude and certainty of bene fito fac li n i c a laction in proportion to risk?. ### Response: The COR.


Instruction: How does the LOE rate the quality ofscientific evidence supporting the intervention?

Output: on thebasis of the type, quantity, and consistency of data fromclinical trials and other sources

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does the LOE rate the quality ofscientific evidence supporting the intervention?. ### Response: on thebasis of the type, quantity, and consistency of data fromclinical trials and other sources.