Instruction: Goldstein H, Spiegelhalter D. League tables and their limitations:statistical issues in comparisons of what?

Output: institutional performance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Goldstein H, Spiegelhalter D. League tables and their limitations:statistical issues in comparisons of what?. ### Response: institutional performance.


Instruction: What year did StatistSoc A publish 159:385–443.784?

Output: 1996

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did StatistSoc A publish 159:385–443.784?. ### Response: 1996.


Instruction: What is the name of the case study that examined the public release of physician and hospital mortality data in Pennsylvania?

Output: Med Care. 1997

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the case study that examined the public release of physician and hospital mortality data in Pennsylvania?. ### Response: Med Care. 1997.


Instruction: Who is Normand S-L?

Output: Shahian D

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Normand S-L?. ### Response: Shahian D.


Instruction: What is the name of the journal that deals with the statistical aspects of hospitaloutcomes profiling?

Output: Statistical Science

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that deals with the statistical aspects of hospitaloutcomes profiling?. ### Response: Statistical Science.


Instruction: What is a position article about Cardiac surgery riskmodels?

Output: Ann Thorac Surg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a position article about Cardiac surgery riskmodels?. ### Response: Ann Thorac Surg.


Instruction: Who is the author of Statistical Science?

Output: Normand S-L, Shahian D

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of Statistical Science?. ### Response: Normand S-L, Shahian D.


Instruction: What is the name of the study that compares hospitaloutcomes with risk-adjusted outcomes?

Output: Circulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that compares hospitaloutcomes with risk-adjusted outcomes?. ### Response: Circulation.


Instruction: When was Performance Measure: Accelerating Improvement published?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Performance Measure: Accelerating Improvement published?. ### Response: 2006.


Instruction: Where is the Institute of Medicine located?

Output: Washington, DC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the Institute of Medicine located?. ### Response: Washington, DC.


Instruction: What is a function of annualcoronary artery bypass graft volume?

Output: Outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a function of annualcoronary artery bypass graft volume?. ### Response: Outcome.


Instruction: What is the Ad Hoc Committee on Cardiac Surgery Credentialing of?

Output: The Society of Thoracic Surgeons

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Ad Hoc Committee on Cardiac Surgery Credentialing of?. ### Response: The Society of Thoracic Surgeons.


Instruction: What is the relationship between inhospital mortality rate and surgicalvolume after controlling for clinical risk factors?

Output: Coronary artery bypasssurgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the relationship between inhospital mortality rate and surgicalvolume after controlling for clinical risk factors?. ### Response: Coronary artery bypasssurgery.


Instruction: What is a regionalization of cardiacsurgery in the United States and Canada?

Output: Geographic access, choice,and outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a regionalization of cardiacsurgery in the United States and Canada?. ### Response: Geographic access, choice,and outcomes.


Instruction: What is the surgicalvolume after controlling for clinical risk factors?

Output: inhospital mortality rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the surgicalvolume after controlling for clinical risk factors?. ### Response: inhospital mortality rate.


Instruction: What are hospitals and surgeons withhigher coronary artery bypass graft surgery volumes still have lowerrisk adjusted mortality rates?

Output: Do hospitals and surgeons withhigher coronary artery bypass graft surgery volumes still have lowerrisk-adjusted mortality rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are hospitals and surgeons withhigher coronary artery bypass graft surgery volumes still have lowerrisk adjusted mortality rates?. ### Response: Do hospitals and surgeons withhigher coronary artery bypass graft surgery volumes still have lowerrisk-adjusted mortality rates.


Instruction: What is the difference between volume and outcome of coronary artery bypassgraft surgery?

Output: more and less the same

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between volume and outcome of coronary artery bypassgraft surgery?. ### Response: more and less the same.


Instruction: When was the can J Cardiol. 20:81–6.796 published?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the can J Cardiol. 20:81–6.796 published?. ### Response: 2004.


Instruction: What is more always better?

Output: coronary artery bypass grafting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more always better?. ### Response: coronary artery bypass grafting.


Instruction: What year was the ACCF/AHA CABG Guideline e719 released?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the ACCF/AHA CABG Guideline e719 released?. ### Response: 2011.


Instruction: What are the 2019 AHA/ACC High Blood Pressure Performance and Quality Measures?

Output: Cardiovasc Qual Outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the 2019 AHA/ACC High Blood Pressure Performance and Quality Measures?. ### Response: Cardiovasc Qual Outcomes.


Instruction: What is the 2017 Hypertension Clinical Practice Guidelines4 recommendations to lower?

Output: BP below the 130/80-mm Hg threshold

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2017 Hypertension Clinical Practice Guidelines4 recommendations to lower?. ### Response: BP below the 130/80-mm Hg threshold.


Instruction: What is the 130/80-mm Hg threshold for both ACC/AHA stage 2 and stage 1 patients?

Output: lower BP below

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 130/80-mm Hg threshold for both ACC/AHA stage 2 and stage 1 patients?. ### Response: lower BP below.


Instruction: The writing committee was sensitive to the fact that there is cur -rently not complete consensus among other guidelines from the American College of Physicians?

Output: ACP) and the American Academy of Family Physicians (AAFP)8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The writing committee was sensitive to the fact that there is cur -rently not complete consensus among other guidelines from the American College of Physicians?. ### Response: ACP) and the American Academy of Family Physicians (AAFP)8.


Instruction: What is the acronym for American College of Physicians?

Output: ACP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for American College of Physicians?. ### Response: ACP.


Instruction: What are the acronyms for the American Academy of Family Physicians and the European Society of Cardiology?

Output: AAFP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the acronyms for the American Academy of Family Physicians and the European Society of Cardiology?. ### Response: AAFP.


Instruction: Who felt it was time to move the US healthcare system forward?

Output: the writing committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who felt it was time to move the US healthcare system forward?. ### Response: the writing committee.


Instruction: What did the writing committee worry would be less likely to consider testing?

Output: NCQA and CMS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the writing committee worry would be less likely to consider testing?. ### Response: NCQA and CMS.


Instruction: What would NCQA and CMS be less likely to consider testing and adopting performance measures with denominator specifications different from those of the “Controlling High Blood Pressure” measure?

Output: the writing committee was concerned that NCQA and CMS would be less likely to consider testing and adopting performance measures with denominator specifications different from those of the “Controlling High Blood Pressure” measure currently in widespread use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would NCQA and CMS be less likely to consider testing and adopting performance measures with denominator specifications different from those of the “Controlling High Blood Pressure” measure?. ### Response: the writing committee was concerned that NCQA and CMS would be less likely to consider testing and adopting performance measures with denominator specifications different from those of the “Controlling High Blood Pressure” measure currently in widespread use.


Instruction: What did the writ-ing committee choose to promote?

Output: flexible denominator congruity and harmonization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the writ-ing committee choose to promote?. ### Response: flexible denominator congruity and harmonization.


Instruction: What is flexible denominator congruity and harmonization defined by?

Output: National Quality Forum

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is flexible denominator congruity and harmonization defined by?. ### Response: National Quality Forum.


Instruction: What did NCQA and CMS mea-sure specifications promote?

Output: its initial widespread use by cli-nicians and entities who support the treatment recom-mendations for ACC/AHA stage 1 HBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did NCQA and CMS mea-sure specifications promote?. ### Response: its initial widespread use by cli-nicians and entities who support the treatment recom-mendations for ACC/AHA stage 1 HBP.


Instruction: Who supports the treatment recommendations for ACC/AHA stage 1 HBP as emphasized in the 2017 Hypertension Clinical Practice Guidelines?

Output: cli-nicians and entities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who supports the treatment recommendations for ACC/AHA stage 1 HBP as emphasized in the 2017 Hypertension Clinical Practice Guidelines?. ### Response: cli-nicians and entities.


Instruction: What new performance measure set also includes a new com-posite measure for control of HBP?

Output: ACC/AHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What new performance measure set also includes a new com-posite measure for control of HBP?. ### Response: ACC/AHA.


Instruction: When was Class of Recommendation and Level of Evidence to Clinical Strategies, Interventions, Treatments or Diagnostic Testing in Patient Care Updated?

Output: August 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Class of Recommendation and Level of Evidence to Clinical Strategies, Interventions, Treatments or Diagnostic Testing in Patient Care Updated?. ### Response: August 2015.


Instruction: When was the class of recommendation and level of evidence to clinical strategies, interventions, treatments or diagnostic testing updated?

Output: August 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the class of recommendation and level of evidence to clinical strategies, interventions, treatments or diagnostic testing updated?. ### Response: August 2015.


Instruction: What is manual auscultatory of fice BPobtained in a protocol-driven standardized setting?

Output: target-ing achieved SBP <90th percentile for age, sex, and heightof normal children

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is manual auscultatory of fice BPobtained in a protocol-driven standardized setting?. ### Response: target-ing achieved SBP <90th percentile for age, sex, and heightof normal children.


Instruction: What is a reasonable approach for children with CKD?

Output: manual auscultatory of ﬁce BPobtained in a protocol-driven standardized setting target-ing achieved SBP <90th percentile for age, sex, and heightof normal children

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a reasonable approach for children with CKD?. ### Response: manual auscultatory of ﬁce BPobtained in a protocol-driven standardized setting target-ing achieved SBP <90th percentile for age, sex, and heightof normal children.


Instruction: What should be used as first line therapy for high BP in children?

Output: ACEi or ARB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be used as first line therapy for high BP in children?. ### Response: ACEi or ARB.


Instruction: How are ACEi and ARB usually tolerated?

Output: well

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are ACEi and ARB usually tolerated?. ### Response: well.


Instruction: What are adverse fetal risks for pregnant women?

Output: they carry therisk of hyperkalemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are adverse fetal risks for pregnant women?. ### Response: they carry therisk of hyperkalemia.


Instruction: What do researchers recommend?

Output: Develop normative reference values for ABPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do researchers recommend?. ### Response: Develop normative reference values for ABPM.


Instruction: What is the best BP measurement technique for pediatric CKDpatients?

Output: hypertension and BP targets

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the best BP measurement technique for pediatric CKDpatients?. ### Response: hypertension and BP targets.


Instruction: What should beinitiated when antihypertensive medications should be?

Output: Ascertain

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should beinitiated when antihypertensive medications should be?. ### Response: Ascertain.


Instruction: How can abpm be obtained repeatedly?

Output: home-based or of ﬁce-based auscultatory or oscillometricBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can abpm be obtained repeatedly?. ### Response: home-based or of ﬁce-based auscultatory or oscillometricBP.


Instruction: What are outcomes of kidney disease progression and CVD?

Output: home-based or of ﬁce-based auscultatory or oscillometricBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are outcomes of kidney disease progression and CVD?. ### Response: home-based or of ﬁce-based auscultatory or oscillometricBP.


Instruction: What is the name of the chapter 5 of Kidney International?

Output: Kidney International

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the chapter 5 of Kidney International?. ### Response: Kidney International.


Instruction: What is a metabolic syndrome?

Output: abdomi -nal obesity, hypertension, diabetes, and dyslipidemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a metabolic syndrome?. ### Response: abdomi -nal obesity, hypertension, diabetes, and dyslipidemia.


Instruction: What are some of the metabolic syndromes?

Output: abdomi -nal obesity, hypertension, diabetes, and dyslipidemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the metabolic syndromes?. ### Response: abdomi -nal obesity, hypertension, diabetes, and dyslipidemia.


Instruction: How many studies were included in SPRINT?

Output: 23

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were included in SPRINT?. ### Response: 23.


Instruction: What is a 10-year risk for cardiovascular dis-ease of 15% or greater based on the Framingham riskscore?

Output: age 75 years or older

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a 10-year risk for cardiovascular dis-ease of 15% or greater based on the Framingham riskscore?. ### Response: age 75 years or older.


Instruction: What did this trial find thattargeting SBP to less than 120 mm Hg compared with lessthan140mmHginadultswithout diabetesorpriorPharmacologic Treatment?

Output: Hypertension in Adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did this trial find thattargeting SBP to less than 120 mm Hg compared with lessthan140mmHginadultswithout diabetesorpriorPharmacologic Treatment?. ### Response: Hypertension in Adults.


Instruction: What is SBP to less than 120 mm Hg?

Output: targeting SBP to less than 120 mm Hg compared withlessthan140mmHginadultswithoutdiabetesorpriorPharmacologic Treatment of Hypertension in Adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SBP to less than 120 mm Hg?. ### Response: targeting SBP to less than 120 mm Hg compared withlessthan140mmHginadultswithoutdiabetesorpriorPharmacologic Treatment of Hypertension in Adults.


Instruction: What is the CLINICAL GUIDELINE for Hypertension in Adults?

Output: Pharmacologic Treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the CLINICAL GUIDELINE for Hypertension in Adults?. ### Response: Pharmacologic Treatment.


Instruction: • Assess the se verity and complexity of t he person's coronary disease using a syst ematic appr oach?

Output: When either r evascularisation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: • Assess the se verity and complexity of t he person's coronary disease using a syst ematic appr oach?. ### Response: When either r evascularisation.


Instruction: What is a r egular multidisciplinar y team meeting to discuss the risks and benefits of continuing drug treatment?

Output: Ensur e

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a r egular multidisciplinar y team meeting to discuss the risks and benefits of continuing drug treatment?. ### Response: Ensur e.


Instruction: What is another name for CABG or PCI?

Output: revascularisation strat egy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for CABG or PCI?. ### Response: revascularisation strat egy.


Instruction: Who should be included in the team?

Output: car diac sur geons and interventional car diologist s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should be included in the team?. ### Response: car diac sur geons and interventional car diologist s.


Instruction: What should be discussed f or the following people?

Output: Treatment strat egy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be discussed f or the following people?. ### Response: Treatment strat egy.


Instruction: What are some people with left main st em or anat omically comple x three-v essel disease?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some people with left main st em or anat omically comple x three-v essel disease?. ### Response: －.


Instruction: What are people in whom t here is doubt about t he best met hod of r evascularisation because of?

Output: t he comple xity of cor onar y

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are people in whom t here is doubt about t he best met hod of r evascularisation because of?. ### Response: t he comple xity of cor onar y.


Instruction: What causes r evascularisation?

Output: the sympt oms of stable angina

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes r evascularisation?. ### Response: the sympt oms of stable angina.


Instruction: What is the extent of st enting and comorbidities?

Output: equir ed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the extent of st enting and comorbidities?. ### Response: equir ed.


Instruction: What is a balanced inf ormation?

Output: stable angina

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a balanced inf ormation?. ### Response: stable angina.


Instruction: What are CABG and PCI?

Output: people wit h stable angina

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are CABG and PCI?. ### Response: people wit h stable angina.


Instruction: What is the main purpose of r evascularisation?

Output: impr ove

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the main purpose of r evascularisation?. ### Response: impr ove.


Instruction: What are CABG and PCI eff ective in?

Output: r elieving sympt oms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are CABG and PCI eff ective in?. ### Response: r elieving sympt oms.


Instruction: What ar e eff ective in r elieving sympt oms?

Output: CABG and PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What ar e eff ective in r elieving sympt oms?. ### Response: CABG and PCI.


Instruction: What is uncommon aft er eit her CABG or PCI?

Output: Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is uncommon aft er eit her CABG or PCI?. ### Response: Stroke.


Instruction: What is a potential survival adv antage wit h CABG f?

Output: Ther e

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a potential survival adv antage wit h CABG f?. ### Response: Ther e.


Instruction: Stable angina: management (CG126) NICE 2022. All right s reserved.

Output: Ther e is a pot ential sur vival adv antage wit h CABG f or some people wit h multiv essel disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Stable angina: management (CG126) NICE 2022. All right s reserved.. ### Response: Ther e is a pot ential sur vival adv antage wit h CABG f or some people wit h multiv essel disease.


Instruction: What is the last updat ed 25 August 2016?

Output: Page 7of 26

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the last updat ed 25 August 2016?. ### Response: Page 7of 26.


Instruction: What is the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al 2020 ACC/AHA Guideline for the Management of Valvular Heart DiseaseCirculation. 2021;143:e72–e227

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al 2020 ACC/AHA Guideline for the Management of Valvular Heart DiseaseCirculation. 2021;143:e72–e227.


Instruction: What does Rosuvastatin affect to slow the progression of aortic stenosis?

Output: aortic valve endothelium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Rosuvastatin affect to slow the progression of aortic stenosis?. ### Response: aortic valve endothelium.


Instruction: What is the progression of aortic stenosis?

Output: slow

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the progression of aortic stenosis?. ### Response: slow.


Instruction: What was the J Am Coll Cardiol. 2007;49:554–61?

Output: Rosuvastatin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the J Am Coll Cardiol. 2007;49:554–61?. ### Response: Rosuvastatin.


Instruction: What is the acronym for calcific aortic valve disease?

Output: Aortic Stenosis Working Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for calcific aortic valve disease?. ### Response: Aortic Stenosis Working Group.


Instruction: What does Metoprolol reduce in asymptomatic valve stenosis patients?

Output: hemody-namic and metabolic overload

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Metoprolol reduce in asymptomatic valve stenosis patients?. ### Response: hemody-namic and metabolic overload.


Instruction: Who is a member of the Blood Institute?

Output: National Heart and Lung and Blood Institute Aortic Stenosis Working Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a member of the Blood Institute?. ### Response: National Heart and Lung and Blood Institute Aortic Stenosis Working Group.


Instruction: What is the name of the drug that inhibits phosphodiesterase type 5 in patients with severe symptomatic aortic stenosis?

Output: Rosuvastatin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug that inhibits phosphodiesterase type 5 in patients with severe symptomatic aortic stenosis?. ### Response: Rosuvastatin.


Instruction: How long does it take for a patient to have a successful 5-year outcome?

Output: 2015;385:2485–91

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take for a patient to have a successful 5-year outcome?. ### Response: 2015;385:2485–91.


Instruction: What is a key factor in determining the timing of intervention?

Output: phosphodiesterase type 5 inhibition

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a key factor in determining the timing of intervention?. ### Response: phosphodiesterase type 5 inhibition.


Instruction: What is the name of the randomised controlled trial that compares transcatheter aortic valve replacement with standard treatment?

Output: PARTNER 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised controlled trial that compares transcatheter aortic valve replacement with standard treatment?. ### Response: PARTNER 1.


Instruction: How long did it take to achieve 5-Year outcomes?

Output: randomised controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take to achieve 5-Year outcomes?. ### Response: randomised controlled trial.


Instruction: What was the outcome of PARTNER 1?

Output: randomised controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome of PARTNER 1?. ### Response: randomised controlled trial.


Instruction: What type of aortic stenosis can be treated with a transcatheter?

Output: severe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of aortic stenosis can be treated with a transcatheter?. ### Response: severe.


Instruction: What is the name of the device that can be used to treat inoperable severe stenosis?

Output: Transcatheter aortic-valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the device that can be used to treat inoperable severe stenosis?. ### Response: Transcatheter aortic-valve replacement.


Instruction: When was the N Engl J Med 366:1696-704 published?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the N Engl J Med 366:1696-704 published?. ### Response: 2012.


Instruction: Med. 2012;366:1696–704. 4. Otto CM, Pearlman AS. Doppler echocardiography in adults with symp-tomatic aortic stenosis. Diagnostic utility and cost-effectiveness. Arch In-tern Med. 1988;148:2553–60.

Output: N Engl J

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Med. 2012;366:1696–704. 4. Otto CM, Pearlman AS. Doppler echocardiography in adults with symp-tomatic aortic stenosis. Diagnostic utility and cost-effectiveness. Arch In-tern Med. 1988;148:2553–60.. ### Response: N Engl J.


Instruction: Turina J, Hess O, Sepulcri F, et al. Spontaneous course of what?

Output: aortic valve dis-ease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Turina J, Hess O, Sepulcri F, et al. Spontaneous course of what?. ### Response: aortic valve dis-ease.


Instruction: What is the name of the study that compares asymptomatic to symptomatic patients older than 20 years of age with valvular aortic stenosis?

Output: Am J Cardiol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that compares asymptomatic to symptomatic patients older than 20 years of age with valvular aortic stenosis?. ### Response: Am J Cardiol.


Instruction: What year did Am J Cardiol. 1988:61:123–30?

Output: 1988

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Am J Cardiol. 1988:61:123–30?. ### Response: 1988.


Instruction: Pellikka PA, Nishimura RA, Bailey KR, et al. have a natural history of adults with what?

Output: asymptomatic, hemodynamically significant aortic stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Pellikka PA, Nishimura RA, Bailey KR, et al. have a natural history of adults with what?. ### Response: asymptomatic, hemodynamically significant aortic stenosis.


Instruction: What is the natural history of adults with asymptomatic, hemodynamically significant aortic stenosis?

Output: 7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the natural history of adults with asymptomatic, hemodynamically significant aortic stenosis?. ### Response: 7.


Instruction: What was the J Am Coll Cardiol. 1990;15:1012–7?

Output: The natural history of adults with asymptomatic, hemodynamically significant aortic stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the J Am Coll Cardiol. 1990;15:1012–7?. ### Response: The natural history of adults with asymptomatic, hemodynamically significant aortic stenosis.


Instruction: Dahl JS, Eleid MF, Michelena HI, et al. Effect of left ventricular ejection fraction on postoperative outcome?

Output: 8. Dahl JS, Eleid MF, Michelena HI, et al. Effect of left ventricular ejection fraction on postoperative outcome in patients with severe aortic ste-nosis undergoing aortic valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Dahl JS, Eleid MF, Michelena HI, et al. Effect of left ventricular ejection fraction on postoperative outcome?. ### Response: 8. Dahl JS, Eleid MF, Michelena HI, et al. Effect of left ventricular ejection fraction on postoperative outcome in patients with severe aortic ste-nosis undergoing aortic valve replacement.


Instruction: Circ Cardiovasc Imaging. 2015;8:e002917

Output: Comparison of outcome of asymptomatic to symptomatic patients older than 20 years of age with valvular aortic stenosis. Am J Cardiol. 1988;61:123–30. 7. Pellikka PA, Nishimura RA, Bailey KR, et al. The natural history of adults with asymptomatic, hemodynamically significant aortic stenosis. J Am Coll Cardiol. 1990;15:1012–7. 8. Dahl JS, Eleid MF, Michelena HI, et al. Effect of left ventricular ejection fraction on postoperative outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circ Cardiovasc Imaging. 2015;8:e002917. ### Response: Comparison of outcome of asymptomatic to symptomatic patients older than 20 years of age with valvular aortic stenosis. Am J Cardiol. 1988;61:123–30. 7. Pellikka PA, Nishimura RA, Bailey KR, et al. The natural history of adults with asymptomatic, hemodynamically significant aortic stenosis. J Am Coll Cardiol. 1990;15:1012–7. 8. Dahl JS, Eleid MF, Michelena HI, et al. Effect of left ventricular ejection fraction on postoperative outcome.


Instruction: What type of stenosis is undergoing aortic valve replacement?

Output: severe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of stenosis is undergoing aortic valve replacement?. ### Response: severe.


Instruction: What year did Circ Cardiovasc Imaging issue 8:e002917?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Circ Cardiovasc Imaging issue 8:e002917?. ### Response: 2015.


Instruction: In what year did JACC Car -diovasc Interv issue 11:145–57?

Output: 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did JACC Car -diovasc Interv issue 11:145–57?. ### Response: 2018.


Instruction: How many hospital admissions for stroke were for stroke patients 80 years of age?

Output: one third

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many hospital admissions for stroke were for stroke patients 80 years of age?. ### Response: one third.


Instruction: What percentage of men with AF were identified as having AF?

Output: 47.2%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of men with AF were identified as having AF?. ### Response: 47.2%).


Instruction: How many men and women had AF?

Output: 15.6%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many men and women had AF?. ### Response: 15.6%.


Instruction: How many women with AF had it?

Output: 1569

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many women with AF had it?. ### Response: 1569.


Instruction: What is the risk stratification of AF for women?

Output: ≥75 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk stratification of AF for women?. ### Response: ≥75 years.


Instruction: Who is less likely to receive anticoagulation therapy?

Output: women with AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is less likely to receive anticoagulation therapy?. ### Response: women with AF.


Instruction: What is one of the most feared compli-cations in patients with AF?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the most feared compli-cations in patients with AF?. ### Response: stroke.


Instruction: What are useful in guiding the decision making for anticoagulation therapy?

Output: Risk stratification tools

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are useful in guiding the decision making for anticoagulation therapy?. ### Response: Risk stratification tools.


Instruction: How many points does the CHADS2 score give for congestive heart failure?

Output: 1 point

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many points does the CHADS2 score give for congestive heart failure?. ### Response: 1 point.


Instruction: What is the chads2 score for diabetes mellitus?

Output: 1 point

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the chads2 score for diabetes mellitus?. ### Response: 1 point.


Instruction: In addition to diabetes, how many points is given for prior stroke/TIA?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In addition to diabetes, how many points is given for prior stroke/TIA?. ### Response: 2.


Instruction: What is an independent predictor of stroke in AF patients?

Output: Female sex

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an independent predictor of stroke in AF patients?. ### Response: Female sex.


Instruction: What is a score of 0 points indicating low risk?

Output: 0.5% to 1.7%);

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a score of 0 points indicating low risk?. ### Response: 0.5% to 1.7%);.


Instruction: What is an independent predictor of stroke in patients with AF?

Output: Female sex

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an independent predictor of stroke in patients with AF?. ### Response: Female sex.


Instruction: What can be considered an exten-sion of the CHADS2 with extra points added for female sex?

Output: A2DS2-V ASc score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be considered an exten-sion of the CHADS2 with extra points added for female sex?. ### Response: A2DS2-V ASc score.


Instruction: How many extra points were added to CHADS2 for female sex?

Output: 1 point

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many extra points were added to CHADS2 for female sex?. ### Response: 1 point.


Instruction: How many points added for previous MI, peripheral arterial disease or aortic plaque?

Output: 1 point

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many points added for previous MI, peripheral arterial disease or aortic plaque?. ### Response: 1 point.


Instruction: What did the American College of Cardiology/AHA/European Society of cardiology guidelines include?

Output: similar risk strati-fication strategies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the American College of Cardiology/AHA/European Society of cardiology guidelines include?. ### Response: similar risk strati-fication strategies.


Instruction: What did the European Society of Cardiology recommend for risk classification?

Output: ASc score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the European Society of Cardiology recommend for risk classification?. ### Response: ASc score.


Instruction: How many large cohort studies have both confirmed an age-sex interaction?

Output: Two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many large cohort studies have both confirmed an age-sex interaction?. ### Response: Two.


Instruction: What percentage of ejection fraction was included in the high-risk category?

Output: <35%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of ejection fraction was included in the high-risk category?. ### Response: <35%.


Instruction: What has been confirmed in large cohort studies?

Output: an age-sex interaction in patients with AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been confirmed in large cohort studies?. ### Response: an age-sex interaction in patients with AF.


Instruction: What suggests a higher risk of stroke in women 75 years with AF compared with men?

Output: age-sex interaction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What suggests a higher risk of stroke in women 75 years with AF compared with men?. ### Response: age-sex interaction.


Instruction: How many patients with nonvalvular AF were included in a large study in Sweden?

Output: 100 802

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with nonvalvular AF were included in a large study in Sweden?. ### Response: 100 802.


Instruction: What was the incident risk of IS greater in women with AF in Sweden than in men?

Output: 6.2% versus 4.2% per year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the incident risk of IS greater in women with AF in Sweden than in men?. ### Response: 6.2% versus 4.2% per year.


Instruction: What percentage of men had nonvalvular AF and 44 115 women had AF from Canada?

Output: 47.2%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of men had nonvalvular AF and 44 115 women had AF from Canada?. ### Response: 47.2%).


Instruction: Who showed a higher crude stroke incidence in women than men?

Output: Canada

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who showed a higher crude stroke incidence in women than men?. ### Response: Canada.


Instruction: What was the stroke incidence per 100 person-year among participants with AF from Canada?

Output: 2.02

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the stroke incidence per 100 person-year among participants with AF from Canada?. ### Response: 2.02.


Instruction: What was the stroke incidence per 100 person-year among participants aged  75 years?

Output: 2.38

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the stroke incidence per 100 person-year among participants aged  75 years?. ### Response: 2.38.


Instruction: How many patients were treated with alirocumab in 2015?

Output: 735

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with alirocumab in 2015?. ### Response: 735.


Instruction: What is the name of the drug used to treat heterozygous familial hypercholesterolaemia?

Output: alirocumab

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used to treat heterozygous familial hypercholesterolaemia?. ### Response: alirocumab.


Instruction: What is a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention?

Output: Harmonizing the metabolic syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention?. ### Response: Harmonizing the metabolic syndrome.


Instruction: What is the acronym for the International Atherosclerosis Society?

Output: World Heart Federation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the International Atherosclerosis Society?. ### Response: World Heart Federation.


Instruction: Who is responsible for Harmonizing the metabolic syndrome?

Output: International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is responsible for Harmonizing the metabolic syndrome?. ### Response: International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity.


Instruction: Study of Obesity. Circulation. 2009;120:1640–5. S3.1.2-4. Grundy SM. Metabolic syndrome: a multiplex cardiovascular risk factor. J Clin Endocrinol Metab. 2007;92:399–404. S3.1.2-5. Aguilar M, Bhuket T, Torres S, et al. Prevalence of the metabolic syn-drome in the United States, 2003–2012 JAMA. 2015;313:1973–4.3.2.

Output: International Association for the Study of Obesity. Circulation. 2009;120:1640–5. S3.1.2-4. Grundy SM. Metabolic syndrome: a multiplex cardiovascular risk factor. J Clin Endocrinol Metab. 2007;92:399–404. S3.1.2-5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Study of Obesity. Circulation. 2009;120:1640–5. S3.1.2-4. Grundy SM. Metabolic syndrome: a multiplex cardiovascular risk factor. J Clin Endocrinol Metab. 2007;92:399–404. S3.1.2-5. Aguilar M, Bhuket T, Torres S, et al. Prevalence of the metabolic syn-drome in the United States, 2003–2012 JAMA. 2015;313:1973–4.3.2.. ### Response: International Association for the Study of Obesity. Circulation. 2009;120:1640–5. S3.1.2-4. Grundy SM. Metabolic syndrome: a multiplex cardiovascular risk factor. J Clin Endocrinol Metab. 2007;92:399–404. S3.1.2-5.


Instruction: What is a scientific statement from the American Heart Association?

Output: Triglycerides and cardio-vascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a scientific statement from the American Heart Association?. ### Response: Triglycerides and cardio-vascular disease.


Instruction: What is the 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce ath-erosclerotic cardiovascular disease?

Output: Statin Therapy S3.2.1-1. Stone NJ, Robinson JG, Lichtenstein AH, et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce ath-erosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce ath-erosclerotic cardiovascular disease?. ### Response: Statin Therapy S3.2.1-1. Stone NJ, Robinson JG, Lichtenstein AH, et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce ath-erosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.


Instruction: What did the American College of Cardiology/American Heart Association Task Force on Practice Guidelines focus on?

Output: the treatment of blood cholesterol to reduce ath-erosclerotic cardiovascular risk in adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the American College of Cardiology/American Heart Association Task Force on Practice Guidelines focus on?. ### Response: the treatment of blood cholesterol to reduce ath-erosclerotic cardiovascular risk in adults.


Instruction: What was the name of the group that did a report on the treatment of blood cholesterol to reduce ath-erosclerotic cardiovascular risk in adults?

Output: American College of Cardiology/American Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the group that did a report on the treatment of blood cholesterol to reduce ath-erosclerotic cardiovascular risk in adults?. ### Response: American College of Cardiology/American Heart Association Task Force on Practice Guidelines.


Instruction: What is the effect of different doses of atorvas-tatin and simvastatin on cholesterol?

Output: Variability

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of different doses of atorvas-tatin and simvastatin on cholesterol?. ### Response: Variability.


Instruction: What is one of the results from VOYAGER?

Output: Variability of low-density lipoprotein cholesterol response

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the results from VOYAGER?. ### Response: Variability of low-density lipoprotein cholesterol response.


Instruction: When was this study published?

Output: May 1, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this study published?. ### Response: May 1, 2023.


Instruction: What type of ablation is considered unsuitable for patients with sympt omatic par oxysmal or persist ent atrial fibrillation?

Output: radiofr equency point -by-point ablation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of ablation is considered unsuitable for patients with sympt omatic par oxysmal or persist ent atrial fibrillation?. ### Response: radiofr equency point -by-point ablation.


Instruction: What should you consider if radiofr equency point -by-point is assessed as not being suitable?

Output: cr yoballoon ablation or laser balloon ablation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should you consider if radiofr equency point -by-point is assessed as not being suitable?. ### Response: cr yoballoon ablation or laser balloon ablation.


Instruction: When considering left atrial ablation, discuss t he risks and what?

Output: benefit s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When considering left atrial ablation, discuss t he risks and what?. ### Response: benefit s.


Instruction: What should you discuss when considering left atrial ablation?

Output: risks and benefit s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should you discuss when considering left atrial ablation?. ### Response: risks and benefit s.


Instruction: What should t he person's pr eferences be taken into account?

Output: risks and pot ential benefit s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should t he person's pr eferences be taken into account?. ### Response: risks and pot ential benefit s.


Instruction: What resolution of sympt oms may not be long-lasting?

Output: t he resolution

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What resolution of sympt oms may not be long-lasting?. ### Response: t he resolution.


Instruction: What should be considered at the same time as ot her cardiothoracic surgery for people wit h what type of atrial fibrillation?

Output: left atrial sur gical ablation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered at the same time as ot her cardiothoracic surgery for people wit h what type of atrial fibrillation?. ### Response: left atrial sur gical ablation.


Instruction: What is the NICE int erventional pr ocedur es guidance on?

Output: left atrial ablation f or atrial fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the NICE int erventional pr ocedur es guidance on?. ### Response: left atrial ablation f or atrial fibrillation.


Instruction: Where can you find NICE guidance on atrial fibrillation?

Output: our t opic page on hear t rhythm conditions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find NICE guidance on atrial fibrillation?. ### Response: our t opic page on hear t rhythm conditions.


Instruction: What is t he rationale and impact section of the 2021 r ecommendations on left atrial ablation?

Output: 1.7.23

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is t he rationale and impact section of the 2021 r ecommendations on left atrial ablation?. ### Response: 1.7.23.


Instruction: Where can full details of evidence and committee's discussion be found?

Output: evidence r eview

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can full details of evidence and committee's discussion be found?. ### Response: evidence r eview.


Instruction: What is evidence r eview J1: ablation?

Output: radiofr equency point -by-point ablation or • if radiofr equency point -by-point ablation is assessed as being unsuitable

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is evidence r eview J1: ablation?. ### Response: radiofr equency point -by-point ablation or • if radiofr equency point -by-point ablation is assessed as being unsuitable.


Instruction: What are the two types of evidence reviews?

Output: J1: ablation , evidence r eview J2: ablation netw ork meta-analysis  and evidence r eview J3: ablation cost -effectiv eness analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the two types of evidence reviews?. ### Response: J1: ablation , evidence r eview J2: ablation netw ork meta-analysis  and evidence r eview J3: ablation cost -effectiv eness analysis.


Instruction: How is ablation cost -effectiv eness analysis calculated?

Output: J3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is ablation cost -effectiv eness analysis calculated?. ### Response: J3.


Instruction: 1.7.22 Consider antiarrh ythmic drug tr eatment f or how many mont hs aft er left atrial ablation to prevent r ecurrence of atrial fibrillation?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: 1.7.22 Consider antiarrh ythmic drug tr eatment f or how many mont hs aft er left atrial ablation to prevent r ecurrence of atrial fibrillation?. ### Response: 3.


Instruction: Take int o account t he person's pr ferences and potential benefit s, and what else?

Output: risks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Take int o account t he person's pr ferences and potential benefit s, and what else?. ### Response: risks.


Instruction: Atrial fibrillation: diagnosis and management (NG196) NICE 2022. All right s reserved.

Output: All right s reserved.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atrial fibrillation: diagnosis and management (NG196) NICE 2022. All right s reserved.. ### Response: All right s reserved..


Instruction: What is the subject of Notice of right s?

Output: Atrial fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the subject of Notice of right s?. ### Response: Atrial fibrillation.


Instruction: When was the last updat ed?

Output: 30 June 2021

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last updat ed?. ### Response: 30 June 2021.


Instruction: What are RCTs examining the effect of blood pressuretargets in patients with CKD without DM?

Output: ACEI or ARBversus placebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are RCTs examining the effect of blood pressuretargets in patients with CKD without DM?. ### Response: ACEI or ARBversus placebo.


Instruction: What is Supplementary Table 4 examining?

Output: the effect of blood pressuretargets

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Supplementary Table 4 examining?. ### Response: the effect of blood pressuretargets.


Instruction: What type of RCTs comparing ACEI orARB versus control (active or placebo) in CKD subgroups with and without DM?

Output: General population

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of RCTs comparing ACEI orARB versus control (active or placebo) in CKD subgroups with and without DM?. ### Response: General population.


Instruction: What is the name of the RCT that examined the effect of ACEI or ARBversus placebo in patients with CKD without DM?

Output: Supplementary Table 8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the RCT that examined the effect of ACEI or ARBversus placebo in patients with CKD without DM?. ### Response: Supplementary Table 8.


Instruction: What is the evidence profile of RCTs examining the effect of ACEI or ARB versus CCB in patients with CKD without DM?

Output: ACEI þCCBversus ACEI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the evidence profile of RCTs examining the effect of ACEI or ARB versus CCB in patients with CKD without DM?. ### Response: ACEI þCCBversus ACEI.


Instruction: What are the outcomes of RCTs examining the effect of ACEI or ARBversus CCB in patients with CKD without DM?

Output: continuous outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the outcomes of RCTs examining the effect of ACEI or ARBversus CCB in patients with CKD without DM?. ### Response: continuous outcomes.


Instruction: How many RCTs examined the effect of ACEI versusARB in patients with CKD without DM?

Output: 15

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs examined the effect of ACEI versusARB in patients with CKD without DM?. ### Response: 15.


Instruction: What is the name of the RCT examining the effect ACE I versus ARB in patient with CCD?

Output: þCCB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the RCT examining the effect ACE I versus ARB in patient with CCD?. ### Response: þCCB.


Instruction: Patient with CKD without DM [continuous outcomes]?

Output: ACEI versusARB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patient with CKD without DM [continuous outcomes]?. ### Response: ACEI versusARB.


Instruction: Evidence profile of RCTs examining the effect of high versus low dose ACEI in patients with what condition?

Output: CKD without DM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Evidence profile of RCTs examining the effect of high versus low dose ACEI in patients with what condition?. ### Response: CKD without DM.


Instruction: What is ACEI in patients with CKD without DM?

Output: ARBversus placebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ACEI in patients with CKD without DM?. ### Response: ARBversus placebo.


Instruction: What are the results of RCTs examining the effect of high versus low dose ARB?

Output: placebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of RCTs examining the effect of high versus low dose ARB?. ### Response: placebo.


Instruction: How many RCTs examined the effect of high doseARB versus low dose ARB in patients with CKD withoutDM?

Output: 20

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs examined the effect of high doseARB versus low dose ARB in patients with CKD withoutDM?. ### Response: 20.


Instruction: Dose ARBversus low dose ARB in patients with CKD without DM?

Output: high doseARB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Dose ARBversus low dose ARB in patients with CKD without DM?. ### Response: high doseARB.


Instruction: What is ACEI versusb-blocker?

Output: effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ACEI versusb-blocker?. ### Response: effect.


Instruction: In patients with CKD without DM, what is ACEI compared to?

Output: placebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with CKD without DM, what is ACEI compared to?. ### Response: placebo.


Instruction: What are RCTs examining the effect of?

Output: blood pressuretargets

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are RCTs examining the effect of?. ### Response: blood pressuretargets.


Instruction: How many mg of sodium is consumed daily?

Output: 2000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mg of sodium is consumed daily?. ### Response: 2000.


Instruction: How many g/d of red meat is consumed per day?

Output: 14

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many g/d of red meat is consumed per day?. ### Response: 14.


Instruction: What type of beverages and processed red meat consumption were associated with cardiovascular death?

Output: sugar-sweetened

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of beverages and processed red meat consumption were associated with cardiovascular death?. ### Response: sugar-sweetened.


Instruction: A prospective cohort study of US healthcare professionals with at least 1 risk factor indicated that replacement of animal protein was associated with what?

Output: reduced cardiovascular mortality rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A prospective cohort study of US healthcare professionals with at least 1 risk factor indicated that replacement of animal protein was associated with what?. ### Response: reduced cardiovascular mortality rate.


Instruction: What was associated with a reduced cardiovascular mortality rate?

Output: replacement of animal protein

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with a reduced cardiovascular mortality rate?. ### Response: replacement of animal protein.


Instruction: What were the sources of cholesterol, saturated fat, heme iron and precursors of trimethylamine-N-oxide?

Output: animal protein

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the sources of cholesterol, saturated fat, heme iron and precursors of trimethylamine-N-oxide?. ### Response: animal protein.


Instruction: How much higher was the mortality rate of poultry and fish compared to plant protein?

Output: 6%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much higher was the mortality rate of poultry and fish compared to plant protein?. ### Response: 6%.


Instruction: How much higher was dairy's mortality rate?

Output: 8%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much higher was dairy's mortality rate?. ### Response: 8%.


Instruction: What was the higher mortality rate of unprocessed red meat?

Output: 12%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the higher mortality rate of unprocessed red meat?. ### Response: 12%.


Instruction: Eggs' mortality rate was what?

Output: 19%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Eggs' mortality rate was what?. ### Response: 19%.


Instruction: Plant protein was associated with a reduction in what percentage of mortality?

Output: 10%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Plant protein was associated with a reduction in what percentage of mortality?. ### Response: 10%.


Instruction: What is the reduction in mortality rate for every 3% energy incre-ment replacement of animal protein?

Output: 10%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the reduction in mortality rate for every 3% energy incre-ment replacement of animal protein?. ### Response: 10%.


Instruction: What has been shown to be potentially harmful or increase risk of ASCVD?

Output: Intake of several food products

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been shown to be potentially harmful or increase risk of ASCVD?. ### Response: Intake of several food products.


Instruction: Sugar-sweetened and artificially sweetened bev-erages have been correlated with increasing the development of what?

Output: T2DM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Sugar-sweetened and artificially sweetened bev-erages have been correlated with increasing the development of what?. ### Response: T2DM.


Instruction: What has been correlated with increasing the development of T2DM and ASCVD risk?

Output: Sugar-sweetened and artificially sweetened bev-erages

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been correlated with increasing the development of T2DM and ASCVD risk?. ### Response: Sugar-sweetened and artificially sweetened bev-erages.


Instruction: How much increase in the frequency of diabetes mellitus with 1 daily serving of sweetened beverages?

Output: 20%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much increase in the frequency of diabetes mellitus with 1 daily serving of sweetened beverages?. ### Response: 20%.


Instruction: In large cohort studies, what has been associated with increased mortality rate?

Output: consump-tion of added sugar

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In large cohort studies, what has been associated with increased mortality rate?. ### Response: consump-tion of added sugar.


Instruction: What has been associated with increased mortality rate?

Output: added sugar

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been associated with increased mortality rate?. ### Response: added sugar.


Instruction: Adults who are habitually high consumers of sugar-sweetened beverages and utilize low calorie sweetened beverages as a replacement strategy may find this useful in the transition to what?

Output: water

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Adults who are habitually high consumers of sugar-sweetened beverages and utilize low calorie sweetened beverages as a replacement strategy may find this useful in the transition to what?. ### Response: water.


Instruction: How much higher is the risk of heart disease in the Southern diet?

Output: 56%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much higher is the risk of heart disease in the Southern diet?. ### Response: 56%.


Instruction: What is the name of the study that identified the Southern dietary pattern as substantially increasing health risks?

Output: REGARDS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that identified the Southern dietary pattern as substantially increasing health risks?. ### Response: REGARDS.


Instruction: How much more risk of stroke is the southern diet associated with?

Output: 30%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much more risk of stroke is the southern diet associated with?. ### Response: 30%.


Instruction: What was the result of a dietS3.1-4 with juices and sweetened beverages, refined grains, potatoes/fries, and sweets?

Output: greater increase in coronary events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the result of a dietS3.1-4 with juices and sweetened beverages, refined grains, potatoes/fries, and sweets?. ### Response: greater increase in coronary events.


Instruction: What was a higher risk of stroke?

Output: 30%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a higher risk of stroke?. ### Response: 30%.


Instruction: What is the risk associated with consumption of animal products?

Output: increased cardiac and noncardiac mortal-ity rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk associated with consumption of animal products?. ### Response: increased cardiac and noncardiac mortal-ity rate.


Instruction: What would clinicians do well to coun-sel individuals about their associated harm and advise them to avoid these foods when possible?

Output: addi-tional risk associated with intake of these various food products

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would clinicians do well to coun-sel individuals about their associated harm and advise them to avoid these foods when possible?. ### Response: addi-tional risk associated with intake of these various food products.


Instruction: Longstanding dietary patterns that focus on low fat diets focus on what?

Output: low intake of carbohydrates and a high intake of animal fat and protein are associated with increased cardiac and noncardiac mortal-ity rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Longstanding dietary patterns that focus on low fat diets focus on what?. ### Response: low intake of carbohydrates and a high intake of animal fat and protein are associated with increased cardiac and noncardiac mortal-ity rate.


Instruction: What are longstanding dietary patterns that focus on low intake of carbohydrates and a high intake of animal fat and protein associated with?

Output: increased cardiac and noncardiac mortal-ity rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are longstanding dietary patterns that focus on low intake of carbohydrates and a high intake of animal fat and protein associated with?. ### Response: increased cardiac and noncardiac mortal-ity rate.


Instruction: Low-carbohydrate diets were associated with a 31% higher risk of all-cause death in 1 meta-analysis?

Output: S3.1-22–S3.1-24 In 1 meta-analysis,S3.1-23 low-carbohydrate diets were associated with a 31% higher risk of all-cause death, with increased cardiac mortality rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Low-carbohydrate diets were associated with a 31% higher risk of all-cause death in 1 meta-analysis?. ### Response: S3.1-22–S3.1-24 In 1 meta-analysis,S3.1-23 low-carbohydrate diets were associated with a 31% higher risk of all-cause death, with increased cardiac mortality rate.


Instruction: How much higher is the risk of all-cause death?

Output: 31%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much higher is the risk of all-cause death?. ### Response: 31%.


Instruction: What is the ARIC?

Output: Atherosclerosis Risk in Communities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ARIC?. ### Response: Atherosclerosis Risk in Communities.


Instruction: How much increased is the cardiac mortality rate?

Output: 18%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much increased is the cardiac mortality rate?. ### Response: 18%.


Instruction: What do antihypertensive agents do in children with CKD?

Output: improve ef ﬁcacy outcomes andreduce adverse effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do antihypertensive agents do in children with CKD?. ### Response: improve ef ﬁcacy outcomes andreduce adverse effects.


Instruction: What are the critical and important outcomes listed in Table 1?

Output: ldosterone antagonists), and non-RAS inhibition (alpha-blockers, beta-blockers,CCBs, diuretics, DRI)Comparator Placebo or standard of careOutcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the critical and important outcomes listed in Table 1?. ### Response: ldosterone antagonists), and non-RAS inhibition (alpha-blockers, beta-blockers,CCBs, diuretics, DRI)Comparator Placebo or standard of careOutcomes.


Instruction: What is ACEi, ARB, aldosterone antagonists used for?

Output: Intervention RAS inhibition

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ACEi, ARB, aldosterone antagonists used for?. ### Response: Intervention RAS inhibition.


Instruction: What is another name for standard of care?

Output: Placebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for standard of care?. ### Response: Placebo.


Instruction: What is the acronym for serum creatinine?

Output: BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for serum creatinine?. ### Response: BP.


Instruction: What is another term for angiotensin-converting enzyme inhibitor?

Output: ACEi

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for angiotensin-converting enzyme inhibitor?. ### Response: ACEi.


Instruction: What is S107ACEi?

Output: angiotensin-converting enzyme inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is S107ACEi?. ### Response: angiotensin-converting enzyme inhibitor.


Instruction: What is ARB?

Output: angiotensin II receptor blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ARB?. ### Response: angiotensin II receptor blocker.


Instruction: What is the acronym for systolic blood pressure?

Output: SBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for systolic blood pressure?. ### Response: SBP.


Instruction: What is a synonym for type 1 diabetes?

Output: T1D

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a synonym for type 1 diabetes?. ### Response: T1D.


Instruction: Powers et al 2019 Guidelines for Management of AIS e407 148. Gorski EM, Schmidt MJ. Orolingual angioedema with alteplase ad-ministration for treatment of acute ischemic stroke.

Output: 10.1016/S0140-6736(07)60149-4 159

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Powers et al 2019 Guidelines for Management of AIS e407 148. Gorski EM, Schmidt MJ. Orolingual angioedema with alteplase ad-ministration for treatment of acute ischemic stroke.. ### Response: 10.1016/S0140-6736(07)60149-4 159.


Instruction: What is the name of the journal that deals with current and emerging therapies?

Output: Lancet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that deals with current and emerging therapies?. ### Response: Lancet.


Instruction: What are the names of the journals that deal with current treatments?

Output: ATLANTIS Trials Investigators; ECASS Trials Investigators; NINDS rt-PA Study Group Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the journals that deal with current treatments?. ### Response: ATLANTIS Trials Investigators; ECASS Trials Investigators; NINDS rt-PA Study Group Investigators.


Instruction: When was the last issue of J Emerg Med published?

Output: 2013.03.045

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last issue of J Emerg Med published?. ### Response: 2013.03.045.


Instruction: What is the incidence and risk of prior angioten-sin-converting enzyme inhibitor use?

Output: Orolingual angioedema

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the incidence and risk of prior angioten-sin-converting enzyme inhibitor use?. ### Response: Orolingual angioedema.


Instruction: What is a reappraisal of orolingual angiodema associated with alteplase treat-ment of acute stroke?

Output: incidence and risk of prior angioten-sin-converting enzyme inhibitor use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a reappraisal of orolingual angiodema associated with alteplase treat-ment of acute stroke?. ### Response: incidence and risk of prior angioten-sin-converting enzyme inhibitor use.


Instruction: What is the name of the journal that studies postthrombolysis hemor -rhagic and orolingual angioedema complications?

Output: Neurohospitalist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies postthrombolysis hemor -rhagic and orolingual angioedema complications?. ### Response: Neurohospitalist.


Instruction: How many pages are in the journal Neurohospitalist?

Output: 150

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many pages are in the journal Neurohospitalist?. ### Response: 150.


Instruction: What is a novel approach to the treatment of orolingual angioedema after tissue plasminogen ac-tivator administration?

Output: Pancioli A

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a novel approach to the treatment of orolingual angioedema after tissue plasminogen ac-tivator administration?. ### Response: Pancioli A.


Instruction: What is thrombolysis for?

Output: acute ischaemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is thrombolysis for?. ### Response: acute ischaemic stroke.


Instruction: What is Cochrane Database Syst Rev. 2014:CD000213?

Output: Thrombolysis for acute ischaemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Cochrane Database Syst Rev. 2014:CD000213?. ### Response: Thrombolysis for acute ischaemic stroke.


Instruction: Who are the ATLANTIS Trials Investigators?

Output: Hacke W, Donnan G, Fieschi C, Kaste M, von Kummer R, Broderick JP, Brott T, Frankel M, Grotta JC, Haley EC Jr, et al; ATLANTIS Trials Investigators; ECASS Trials Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who are the ATLANTIS Trials Investigators?. ### Response: Hacke W, Donnan G, Fieschi C, Kaste M, von Kummer R, Broderick JP, Brott T, Frankel M, Grotta JC, Haley EC Jr, et al; ATLANTIS Trials Investigators; ECASS Trials Investigators.


Instruction: What is the association of outcome with early stroke treatment?

Output: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association of outcome with early stroke treatment?. ### Response: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials.


Instruction: When was the Lancet 363:768-774?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Lancet 363:768-774?. ### Response: 2004.


Instruction: What is the name of the rt-PA stroke trials?

Output: NINDS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the rt-PA stroke trials?. ### Response: NINDS.


Instruction: When was the Lancet 379:2364-2372 published?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Lancet 379:2364-2372 published?. ### Response: 2012.


Instruction: What was the title of the 2004 Lancet 363:768-774?

Output: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the title of the 2004 Lancet 363:768-774?. ### Response: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials.


Instruction: What does SITS-MOST stand for?

Output: Safe Implementation of Thrombolysis in Stroke-Monitoring Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does SITS-MOST stand for?. ### Response: Safe Implementation of Thrombolysis in Stroke-Monitoring Study.


Instruction: What is the name of the observational study that evaluated thrombolysis with alteplase?

Output: SITS-MOST Investigators. Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the observational study that evaluated thrombolysis with alteplase?. ### Response: SITS-MOST Investigators. Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST.


Instruction: What is the acronym for Thrombolysis in Stroke-Monitoring Study?

Output: SITS-MOST

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Thrombolysis in Stroke-Monitoring Study?. ### Response: SITS-MOST.


Instruction: What is SITS-MOST?

Output: Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SITS-MOST?. ### Response: Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study.


Instruction: When was the Lancet 369:275-282?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Lancet 369:275-282?. ### Response: 2007.


Instruction: What are the risk factors for ischemicstroke and TE?

Output: Patients with AF- Established clinical riskfactors- Risk factors onechocardiography- Novel risk factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the risk factors for ischemicstroke and TE?. ### Response: Patients with AF- Established clinical riskfactors- Risk factors onechocardiography- Novel risk factors.


Instruction: What are established clinical riskfactors?

Output: Risk factors onechocardiography- Novel risk factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are established clinical riskfactors?. ### Response: Risk factors onechocardiography- Novel risk factors.


Instruction: What is onechocardiography- Novel risk factors?

Output: Risk factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is onechocardiography- Novel risk factors?. ### Response: Risk factors.


Instruction: Patients with chronic atrialflutterNA NA Ischemic strokeSystemicTEMortalityCohort studiesNon-warfarinarms ofRCTs1.3 Risk strati fication forischemic strokeand TE What are the bene fitsand TEC?

Output: Established clinical riskfactors- Risk factors onechocardiography- Novel risk factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with chronic atrialflutterNA NA Ischemic strokeSystemicTEMortalityCohort studiesNon-warfarinarms ofRCTs1.3 Risk strati fication forischemic strokeand TE What are the bene fitsand TEC?. ### Response: Established clinical riskfactors- Risk factors onechocardiography- Novel risk factors.


Instruction: What are the bene fitsand risks ofdifferent strokepreventionstrategies?

Output: Low risk- Intermediate risk- High risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the bene fitsand risks ofdifferent strokepreventionstrategies?. ### Response: Low risk- Intermediate risk- High risk.


Instruction: What are patients withnonvalvular AF- Low risk- Intermediate risk- High risk (including priorstroke)?

Output: different strokepreventionstrategies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients withnonvalvular AF- Low risk- Intermediate risk- High risk (including priorstroke)?. ### Response: different strokepreventionstrategies.


Instruction: Who was not involved in the Work Group?

Output: patients or caregivers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was not involved in the Work Group?. ### Response: patients or caregivers.


Instruction: Who made judgments on the preferences and values of patients?

Output: The Work Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who made judgments on the preferences and values of patients?. ### Response: The Work Group.


Instruction: What was the formal qualitative evidence syn-thesis on?

Output: patient priorities and preferences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the formal qualitative evidence syn-thesis on?. ### Response: patient priorities and preferences.


Instruction: What was not undertaken?

Output: formal systematic evidencereview

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not undertaken?. ### Response: formal systematic evidencereview.


Instruction: What were considered in grading the strength of a recommendation?

Output: Healthcare and non-healthcare resources

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were considered in grading the strength of a recommendation?. ### Response: Healthcare and non-healthcare resources.


Instruction: What was not conducted for any of the guideline topics?

Output: Economic evaluations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not conducted for any of the guideline topics?. ### Response: Economic evaluations.


Instruction: What did the ERT conduct searches for?

Output: systematic reviews of cost-effectiveness studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the ERT conduct searches for?. ### Response: systematic reviews of cost-effectiveness studies.


Instruction: What do KDIGO guidelines include in addition to graded recommendations?

Output: practice points

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do KDIGO guidelines include in addition to graded recommendations?. ### Response: practice points.


Instruction: What do practice points help clinicians better evaluate and implement?

Output: the guidance from the expert Work Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do practice points help clinicians better evaluate and implement?. ### Response: the guidance from the expert Work Group.


Instruction: What was used when there was no formal systematic evidencereview?

Output: supplement recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was used when there was no formal systematic evidencereview?. ### Response: supplement recommendations.


Instruction: What represent the expert judgment of the guideline Work Group?

Output: Practice points

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What represent the expert judgment of the guideline Work Group?. ### Response: Practice points.


Instruction: How were practice points formatted to make them easier to use in clinicalpractice?

Output: as a table,aﬁgure, or an algorithm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How were practice points formatted to make them easier to use in clinicalpractice?. ### Response: as a table,aﬁgure, or an algorithm.


Instruction: What does each guideline recommendation provide an assessment of?

Output: thestrength of the recommendation (strong, level 1 or weak, level 2) andthe quality of evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does each guideline recommendation provide an assessment of?. ### Response: thestrength of the recommendation (strong, level 1 or weak, level 2) andthe quality of evidence.


Instruction: What does recommendation provide an assessment of?

Output: strength of the recommendation (strong, level 1 or weak, level 2) andthe quality of evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does recommendation provide an assessment of?. ### Response: strength of the recommendation (strong, level 1 or weak, level 2) andthe quality of evidence.