Instruction: What percentage of the probability of 400ppm being the cost effective option is 62%?

Output: 0.9929

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the probability of 400ppm being the cost effective option is 62%?. ### Response: 0.9929.


Instruction: Antiplatelet Treatment COR LOE New, Revised, or Unchanged?

Output: 3.9. Antiplatelet Treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Antiplatelet Treatment COR LOE New, Revised, or Unchanged?. ### Response: 3.9. Antiplatelet Treatment.


Instruction: What is recommended in patients with AIS within 24 to 48 hours after onset?

Output: Administration of aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended in patients with AIS within 24 to 48 hours after onset?. ### Response: Administration of aspirin.


Instruction: For those treated with IV alteplase, aspirin administration is generally delayed until how long?

Output: 24 hours later

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For those treated with IV alteplase, aspirin administration is generally delayed until how long?. ### Response: 24 hours later.


Instruction: What is known to provide substantial benefit or withholding such treatment causes substantial risk?

Output: such treatment given in the absence of IV alteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is known to provide substantial benefit or withholding such treatment causes substantial risk?. ### Response: such treatment given in the absence of IV alteplase.


Instruction: What is the safety and benefit of IV alteplase?

Output: risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the safety and benefit of IV alteplase?. ### Response: risk.


Instruction: When was ARecommendation revised from?

Output: 2013 AIS Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was ARecommendation revised from?. ### Response: 2013 AIS Guidelines.


Instruction: How many large clinical trials established the safety and benefit of aspirin in the treatment of patients with AIS?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many large clinical trials established the safety and benefit of aspirin in the treatment of patients with AIS?. ### Response: 2.


Instruction: What has recently been confirmed by a large Cochrane review?

Output: The safety and benefit of aspirin in the treatment of patients with AIS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has recently been confirmed by a large Cochrane review?. ### Response: The safety and benefit of aspirin in the treatment of patients with AIS.


Instruction: Cochrane review of aspirin trials.

Output: The safety and benefit of aspirin in the treatment of patients with AIS were established by 2 large clinical trials administering doses between 160 and 300 mg.207,208

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cochrane review of aspirin trials.. ### Response: The safety and benefit of aspirin in the treatment of patients with AIS were established by 2 large clinical trials administering doses between 160 and 300 mg.207,208.


Instruction: What is appropriate in patients unsafe or unable to swallow?

Output: rectal or nasogastric administration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is appropriate in patients unsafe or unable to swallow?. ### Response: rectal or nasogastric administration.


Instruction: What exist on the use of alternative antiplatelet agents in the treatment of AIS?

Output: Limited data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What exist on the use of alternative antiplatelet agents in the treatment of AIS?. ### Response: Limited data.


Instruction: What may be reasonable?

Output: administering alternative antiplatelet agents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be reasonable?. ### Response: administering alternative antiplatelet agents.


Instruction: How long after IV alteplase or EVT did initiation of antiplatelet or anticoagulant therapy last?

Output: (<24 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after IV alteplase or EVT did initiation of antiplatelet or anticoagulant therapy last?. ### Response: (<24 hours.


Instruction: Where was a retrospective analysis of consecutive ischemic stroke patients admitted to a single center?

Output: Seoul, South Korea

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where was a retrospective analysis of consecutive ischemic stroke patients admitted to a single center?. ### Response: Seoul, South Korea.


Instruction: How long after IV alteplase or EVT was antiplatelet therapy compared with initiation >24 hours?

Output: (<24 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after IV alteplase or EVT was antiplatelet therapy compared with initiation >24 hours?. ### Response: (<24 hours.


Instruction: The study may have been subject to what?

Output: selection bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The study may have been subject to what?. ### Response: selection bias.


Instruction: What should be made on an individual level, balancing risk and benefit?

Output: the timing of initiation of antiplatelet therapy or anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be made on an individual level, balancing risk and benefit?. ### Response: the timing of initiation of antiplatelet therapy or anticoagulation.


Instruction: What is the initial dosing recommendation for AIS?

Output: 325 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the initial dosing recommendation for AIS?. ### Response: 325 mg.


Instruction: What was removed from the previous guideline?

Output: specific dosing recommendation “initial dose is 325 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was removed from the previous guideline?. ### Response: specific dosing recommendation “initial dose is 325 mg.


Instruction: Why was the initial dose of AIS removed?

Output: previous clinical trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the initial dose of AIS removed?. ### Response: previous clinical trials.


Instruction: How many doses were included in previous clinical trials?

Output: 160 to 300 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many doses were included in previous clinical trials?. ### Response: 160 to 300 mg.


Instruction: When was XLVIII in online Data Supplement 1 downloaded from http://ahajournals.org?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was XLVIII in online Data Supplement 1 downloaded from http://ahajournals.org?. ### Response: April 28, 2023.


Instruction: Who is the representative of the American College of Emergency Physicians?

Output: Dr. Francis M. Fesmire

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the representative of the American College of Emergency Physicians?. ### Response: Dr. Francis M. Fesmire.


Instruction: Who died during the development of this document?

Output: Dr. Francis M. Fesmire

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who died during the development of this document?. ### Response: Dr. Francis M. Fesmire.


Instruction: What contributed immensely to our understanding of non-ST-elevation acute coronary syndromes?

Output: Dr. Francis M. Fesmire

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What contributed immensely to our understanding of non-ST-elevation acute coronary syndromes?. ### Response: Dr. Francis M. Fesmire.


Instruction: Who may apply for recusal?

Output: their specific relationships with industry and other entities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who may apply for recusal?. ### Response: their specific relationships with industry and other entities.


Instruction: Who is the ACC/AHA Representative?

Output: American College of Physicians Representative

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the ACC/AHA Representative?. ### Response: American College of Physicians Representative.


Instruction: What is the Society of Thoracic Surgeons representative?

Output: Society for Cardiovascular Angiography and Interventions Representative

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Society of Thoracic Surgeons representative?. ### Response: Society for Cardiovascular Angiography and Interventions Representative.


Instruction: Which organization is the current member of the Task Force?

Output: Society for Cardiovascular Angiography and Interventions Representative

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which organization is the current member of the Task Force?. ### Response: Society for Cardiovascular Angiography and Interventions Representative.


Instruction: Who approved this document?

Output: American Heart Association Science Advisory and Coordinating Committee and the American College of Cardiology Board of Trustees

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who approved this document?. ### Response: American Heart Association Science Advisory and Coordinating Committee and the American College of Cardiology Board of Trustees.


Instruction: When was this document approved?

Output: August 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this document approved?. ### Response: August 2014.


Instruction: Where is the online-only Comprehensive Relationships Data Supplement?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the online-only Comprehensive Relationships Data Supplement?. ### Response: http://circ.ahajournals.org.


Instruction: What is available with this article at http://circ.ahajournals.org/lookup/suppl/doi:10.1161/CIR.0000000000000134/-/DC1?

Output: Comprehensive Relationships Data Supplement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is available with this article at http://circ.ahajournals.org/lookup/suppl/doi:10.1161/CIR.0000000000000134/-/DC1?. ### Response: Comprehensive Relationships Data Supplement.


Instruction: Where are the online-only Data Supplement files available?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are the online-only Data Supplement files available?. ### Response: http://circ.ahajournals.org/lookup/suppl/doi:10.1161/CIR.0000000000000134/-/DC2.


Instruction: Who requests that this document be cited?

Output: The American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who requests that this document be cited?. ### Response: The American Heart Association.


Instruction: What is the 2014 ACC/AHA guideline for the management of patients with non-ST-elevation acute coronary syndromes?

Output: AHA/ACC Guidelinee344

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2014 ACC/AHA guideline for the management of patients with non-ST-elevation acute coronary syndromes?. ### Response: AHA/ACC Guidelinee344.


Instruction: What is a report of the American College of Cardiology/American Heart Association Task Force?

Output: Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a report of the American College of Cardiology/American Heart Association Task Force?. ### Response: Practice Guidelines.


Instruction: What is the name of the Task Force on Practice Guidelines?

Output: American College of Cardiology/American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Practice Guidelines?. ### Response: American College of Cardiology/American Heart Association.


Instruction: What journal is the article published in?

Output: Journal of the American College of Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What journal is the article published in?. ### Response: Journal of the American College of Cardiology.


Instruction: Where is the document available?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the document available?. ### Response: http://circ.ahajournals.org.


Instruction: What is the name of the organization that publishes the AHA Scientific Statements?

Output: AHA Office of Science Operations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that publishes the AHA Scientific Statements?. ### Response: AHA Office of Science Operations.


Instruction: Where can one obtain a copy of AHA's Statements from?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can one obtain a copy of AHA's Statements from?. ### Response: http://circ.ahajournals.org.


Instruction: What are the names of the two organizations that publish AHA statements?

Output: American Heart Association, Inc., and the American College of Cardiology Foundation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the two organizations that publish AHA statements?. ### Response: American Heart Association, Inc., and the American College of Cardiology Foundation.


Instruction: Who conducts the peer review of the Statements produced by AHA?

Output: Office of Science Operations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who conducts the peer review of the Statements produced by AHA?. ### Response: Office of Science Operations.


Instruction: Who conducts expert peer review of AHA Scientific Statements?

Output: AHA Office of Science Operations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who conducts expert peer review of AHA Scientific Statements?. ### Response: AHA Office of Science Operations.


Instruction: Where can you find more information on AHA statements and guidelines development?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find more information on AHA statements and guidelines development?. ### Response: http://my.americanheart.org/statements.


Instruction: What has been implicated as a reason for the potential detrimental cardiovascular effect of older-generation sulfonylureas?

Output: cardiac ischemic preconditioning

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been implicated as a reason for the potential detrimental cardiovascular effect of older-generation sulfonylureas?. ### Response: cardiac ischemic preconditioning.


Instruction: What are nonselective effects of these agents on?

Output: pancreatic and cardiac K-ATPase channels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are nonselective effects of these agents on?. ### Response: pancreatic and cardiac K-ATPase channels.


Instruction: What are the effects of sulfonylureas on pancreatic and cardiac K-ATPase channels?

Output: nonselective effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the effects of sulfonylureas on pancreatic and cardiac K-ATPase channels?. ### Response: nonselective effects.


Instruction: What is the side-effect profile of incretin-based therapies?

Output: less risk of hypoglycemia and association with modest weight loss with GLP-1 ago-nists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the side-effect profile of incretin-based therapies?. ### Response: less risk of hypoglycemia and association with modest weight loss with GLP-1 ago-nists.


Instruction: What is a new class of hyperglycemic medications?

Output: incretin-based therapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a new class of hyperglycemic medications?. ### Response: incretin-based therapies.


Instruction: What is the side-effect profile of these medications when used as monotherapy?

Output: less risk of hypoglycemia and association with modest weight loss with GLP-1 ago-nists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the side-effect profile of these medications when used as monotherapy?. ### Response: less risk of hypoglycemia and association with modest weight loss with GLP-1 ago-nists.


Instruction: The safety and efficacy of DPP-4 inhibitors and GLP-1 agonists have not been studied extensively in patients?

Output: with established HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The safety and efficacy of DPP-4 inhibitors and GLP-1 agonists have not been studied extensively in patients?. ### Response: with established HF.


Instruction: GLP-1 agonists have not been studied extensively in patients with what type of HF?

Output: established

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: GLP-1 agonists have not been studied extensively in patients with what type of HF?. ### Response: established.


Instruction: Human studies of DPP-4 inhibitors and thera-pies have been limited by what?

Output: HF not being identified as a prospective primary outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Human studies of DPP-4 inhibitors and thera-pies have been limited by what?. ### Response: HF not being identified as a prospective primary outcome.


Instruction: HF not being identified as a primary outcome has resulted in what mixed results?

Output: cardio-vascular versus HF outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: HF not being identified as a primary outcome has resulted in what mixed results?. ### Response: cardio-vascular versus HF outcomes.


Instruction: What have patients with HF yielded mixed results in?

Output: cardio-vascular versus HF outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have patients with HF yielded mixed results in?. ### Response: cardio-vascular versus HF outcomes.


Instruction: What did the SAVOR-TIMI 53 trial report?

Output: a 27% increase in hospitalization for HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the SAVOR-TIMI 53 trial report?. ### Response: a 27% increase in hospitalization for HF.


Instruction: Who reported a 27% increase in hospitalization for HF among patients with diabetes mel-litus who received saxagliptin compared with placebo?

Output: Scirica et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who reported a 27% increase in hospitalization for HF among patients with diabetes mel-litus who received saxagliptin compared with placebo?. ### Response: Scirica et al.


Instruction: What percentage of patients had a history of HF at baseline?

Output: 12.8%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients had a history of HF at baseline?. ### Response: 12.8%.


Instruction: What was the composite risk of cardiovascular events and hospitalization for HF for patients with a history of HF at baseline?

Output: similar

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the composite risk of cardiovascular events and hospitalization for HF for patients with a history of HF at baseline?. ### Response: similar.


Instruction: What was similar for patients without HF with the use of saxagliptin?

Output: The composite risk of cardiovascular events and hospitalization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was similar for patients without HF with the use of saxagliptin?. ### Response: The composite risk of cardiovascular events and hospitalization.


Instruction: A recent meta-anal-ysis of available studies suggests that DPP-4 inhibitor use is associated with what?

Output: an increased risk of HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A recent meta-anal-ysis of available studies suggests that DPP-4 inhibitor use is associated with what?. ### Response: an increased risk of HF.


Instruction: DPP-4 inhibitor use is associated with an increased risk of what?

Output: HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: DPP-4 inhibitor use is associated with an increased risk of what?. ### Response: HF.


Instruction: There is no clear evidence of differences among drugs of what class?

Output: DPP-4 inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is no clear evidence of differences among drugs of what class?. ### Response: DPP-4 inhibitor.


Instruction: Additional studies are being conducted to asses the cardiovascular efficacy of what two therapies?

Output: DPP-4 inhibitors and GLP-1–based therapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Additional studies are being conducted to asses the cardiovascular efficacy of what two therapies?. ### Response: DPP-4 inhibitors and GLP-1–based therapies.


Instruction: What is measured as a secondary outcome of incretin-based therapies?

Output: HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is measured as a secondary outcome of incretin-based therapies?. ### Response: HF.


Instruction: What type of therapy may provide insights into the safety and efficacy?

Output: incretin-based

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy may provide insights into the safety and efficacy?. ### Response: incretin-based.


Instruction: How many patients with diabetes mellitus and HF will require insulin therapy?

Output: Many

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with diabetes mellitus and HF will require insulin therapy?. ### Response: Many.


Instruction: What will require insulin therapy to achieve adequate glycemic control?

Output: Many patients with diabetes mellitus and HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will require insulin therapy to achieve adequate glycemic control?. ### Response: Many patients with diabetes mellitus and HF.


Instruction: What is associated with hypoglycemia and weight gain?

Output: Insulin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with hypoglycemia and weight gain?. ### Response: Insulin.


Instruction: In-sulin use may be associated with what?

Output: modest weight loss

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In-sulin use may be associated with what?. ### Response: modest weight loss.


Instruction: What did Meschia and al Guidelines for the Primary Prevention of Stroke 3793Some but not all population-based epidemiological studies have found that Lp(a) is associated with an increased risk of stroke?

Output: 801

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Meschia and al Guidelines for the Primary Prevention of Stroke 3793Some but not all population-based epidemiological studies have found that Lp(a) is associated with an increased risk of stroke?. ### Response: 801.


Instruction: In the Physicians' Health Study, what was there no association between baseline plasma plasma and stroke risk?

Output: concentration of Lp(a)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the Physicians' Health Study, what was there no association between baseline plasma plasma and stroke risk?. ### Response: concentration of Lp(a).


Instruction: What type of men had no association between baseline plasma concentration of Lp(a) and future risk of stroke?

Output: healthy, white, middle-aged men

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of men had no association between baseline plasma concentration of Lp(a) and future risk of stroke?. ### Response: healthy, white, middle-aged men.


Instruction: In the CHS, what was the increase in risk for stroke in older men?

Output: 3-fold

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the CHS, what was the increase in risk for stroke in older men?. ### Response: 3-fold.


Instruction: What was the RR of 3.00?

Output: 3-fold

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the RR of 3.00?. ### Response: 3-fold.


Instruction: How much was the risk of a stroke increased by older men whose levels were in the highest quintile?

Output: 3-fold

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much was the risk of a stroke increased by older men whose levels were in the highest quintile?. ### Response: 3-fold.


Instruction: In the ARIC study, the incidence of ischemic stroke was sig-nificantly increased in individuals with higher Lp(a) levels after adjustment for age, sex, and CVD risk factors?

Output: 801

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the ARIC study, the incidence of ischemic stroke was sig-nificantly increased in individuals with higher Lp(a) levels after adjustment for age, sex, and CVD risk factors?. ### Response: 801.


Instruction: How much greater was the incidence of ischemic stroke in blacks with Lp(a) >30 mg/dL?

Output: 2.12-fold greater

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much greater was the incidence of ischemic stroke in blacks with Lp(a) >30 mg/dL?. ### Response: 2.12-fold greater.


Instruction: What was the RR in whites?

Output: 1.65

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the RR in whites?. ### Response: 1.65.


Instruction: How much greater was the Lp(a) level in whites?

Output: 1.65-fold greater

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much greater was the Lp(a) level in whites?. ### Response: 1.65-fold greater.


Instruction: What is the 95% confidence interval?

Output: 1.59–5.65

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 95% confidence interval?. ### Response: 1.59–5.65.


Instruction: How many studies have found that Lp levels are associated with the severity of carotid artery stenosis and occlusion?

Output: Several

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies have found that Lp levels are associated with the severity of carotid artery stenosis and occlusion?. ### Response: Several.


Instruction: What is more common in stroke patients with large-vessel atherothrombotic disease than in patients with lacunar strokes?

Output: Lp(a) levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more common in stroke patients with large-vessel atherothrombotic disease than in patients with lacunar strokes?. ### Response: Lp(a) levels.


Instruction: How many studies comprised of 56 010 subjects found that Lp(a) was higher?

Output: 31

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies comprised of 56 010 subjects found that Lp(a) was higher?. ### Response: 31.


Instruction: What percentage more frequent in patients in the high-est compared with the low-est?

Output: 22%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage more frequent in patients in the high-est compared with the low-est?. ### Response: 22%.


Instruction: What is more frequent in patients in the high-est tertile of Lp(a)?

Output: incident stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more frequent in patients in the high-est tertile of Lp(a)?. ### Response: incident stroke.


Instruction: A recent study assessed the value of emerging circulating lipid markers such as what?

Output: Lp(a)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A recent study assessed the value of emerging circulating lipid markers such as what?. ### Response: Lp(a).


Instruction: What did Lp(a) to that on conventional risk factors improve the prediction of?

Output: cardio-vascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Lp(a) to that on conventional risk factors improve the prediction of?. ### Response: cardio-vascular events.


Instruction: What would reclassify 4% of individuals to a 20% predicted risk of having a cardiovascular event within 10 years?

Output: statin treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would reclassify 4% of individuals to a 20% predicted risk of having a cardiovascular event within 10 years?. ### Response: statin treatment.


Instruction: What did a meta-analysis of observational studies report an asso-ciation of elevated Lp(a) with first childhood arterial ischemic stroke?

Output: 810

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a meta-analysis of observational studies report an asso-ciation of elevated Lp(a) with first childhood arterial ischemic stroke?. ### Response: 810.


Instruction: What was also associated with recurrent arterial isch-emic stroke in children?

Output: ele-vated Lp(a)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was also associated with recurrent arterial isch-emic stroke in children?. ### Response: ele-vated Lp(a).


Instruction: What does niacin do to Lp(a) levels?

Output: lowers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does niacin do to Lp(a) levels?. ### Response: lowers.


Instruction: How many subjects were included in a meta-analysis of sec-ondary prevention trials?

Output: 9959

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many subjects were included in a meta-analysis of sec-ondary prevention trials?. ### Response: 9959.


Instruction: What was the relative odds reduction of any CVD event?

Output: 34%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the relative odds reduction of any CVD event?. ### Response: 34%.


Instruction: What is associated with a higher risk of stroke?

Output: Lp(a)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with a higher risk of stroke?. ### Response: Lp(a).


Instruction: What has not shown that niacin supplementation lowers stroke risk?

Output: randomized trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has not shown that niacin supplementation lowers stroke risk?. ### Response: randomized trials.


Instruction: What increases cerebral oxygen delivery in anemicpatients with subarachnoid hemorrhage?

Output: Red blood cell transfusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What increases cerebral oxygen delivery in anemicpatients with subarachnoid hemorrhage?. ### Response: Red blood cell transfusion.


Instruction: What is associated with higher hemoglobin?

Output: improved outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with higher hemoglobin?. ### Response: improved outcome.


Instruction: What is associated with less cerebral infarction, pooroutcome, and death after subarachnoid hemorrhage?

Output: Higher hemoglobin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with less cerebral infarction, pooroutcome, and death after subarachnoid hemorrhage?. ### Response: Higher hemoglobin.


Instruction: What is higher hemoglobin asso-ciated with?

Output: improved outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is higher hemoglobin asso-ciated with?. ### Response: improved outcome.


Instruction: Crit Care Med. 2007;35:2383–2389.330. Kramer AH, Gurka MJ, Nathan B, Dumont AS, Kassell NF, Bleck TP.Complications associated with anemia and blood transfusion in patientswith aneurysmal subarachnoid hemorrhage.

Output: Higher hemoglobin is asso-ciated with improved outcome after subarachnoid hemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Crit Care Med. 2007;35:2383–2389.330. Kramer AH, Gurka MJ, Nathan B, Dumont AS, Kassell NF, Bleck TP.Complications associated with anemia and blood transfusion in patientswith aneurysmal subarachnoid hemorrhage.. ### Response: Higher hemoglobin is asso-ciated with improved outcome after subarachnoid hemorrhage.


Instruction: What is the name of the prospective, ran-domized trial of higher goal hemoglobin after subarachnoid hemorrhage?

Output: CritCare Med

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective, ran-domized trial of higher goal hemoglobin after subarachnoid hemorrhage?. ### Response: CritCare Med.


Instruction: What does blood transfusion and increased risk for vasospasm and poor outcome after?

Output: subarachnoidhemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does blood transfusion and increased risk for vasospasm and poor outcome after?. ### Response: subarachnoidhemorrhage.


Instruction: What was Alberts MJ's title?

Output: Neurosurgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was Alberts MJ's title?. ### Response: Neurosurgery.


Instruction: What is heparin-induced thrombocytopenia type II in patients with subarachnoid hem-orrhage treated with?

Output: heparin versus enoxaparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is heparin-induced thrombocytopenia type II in patients with subarachnoid hem-orrhage treated with?. ### Response: heparin versus enoxaparin.


Instruction: What is the difference between enoxaparin and hisparin?

Output: incidence of heparin-induced thrombocytopenia type II

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between enoxaparin and hisparin?. ### Response: incidence of heparin-induced thrombocytopenia type II.


Instruction: In what year did J Neurosurg 2009 release 110:50-57.335?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did J Neurosurg 2009 release 110:50-57.335?. ### Response: 2009.


Instruction: What is heparin-induced thrombocy-topenia type II in subarachnoid hemorrhage patients: incidence andcomplications?

Output: Risk factors for heparin-induced thrombocytopenia type II in aneu-rysmal subarachnoid hemorrhage. Neurosurgery . 2011;69:1030–1036.334. Kim GH, Hahn DK, Kellner CP, Komotar RJ, Starke R, Garrett MC,Yao J, Cleveland J, Mayer SA, Connolly ES. The incidence of heparin-induced thrombocytopenia type II in patients with subarachnoid hem-orrhage treated with heparin versus enoxaparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is heparin-induced thrombocy-topenia type II in subarachnoid hemorrhage patients: incidence andcomplications?. ### Response: Risk factors for heparin-induced thrombocytopenia type II in aneu-rysmal subarachnoid hemorrhage. Neurosurgery . 2011;69:1030–1036.334. Kim GH, Hahn DK, Kellner CP, Komotar RJ, Starke R, Garrett MC,Yao J, Cleveland J, Mayer SA, Connolly ES. The incidence of heparin-induced thrombocytopenia type II in patients with subarachnoid hem-orrhage treated with heparin versus enoxaparin.


Instruction: What is Lassila R, Antovic JP, Armstrong E, Baghaei F, Holme PA, Holmstrom M, Johnsson H, Joutsi-Korhonen L, Sandset PM?

Output: Neurosurgery . 2005;57:243–248.336. Lassila R, Antovic JP, Armstrong E, Baghaei F, Dalsgaard-Nielsen J,Hillarp A, Holme PA, Holmstrom M, Johnsson H, Joutsi-Korhonen L,Sandset PM. Practical viewpoints on the diagnosis and management ofheparin-induced thrombocytopenia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Lassila R, Antovic JP, Armstrong E, Baghaei F, Holme PA, Holmstrom M, Johnsson H, Joutsi-Korhonen L, Sandset PM?. ### Response: Neurosurgery . 2005;57:243–248.336. Lassila R, Antovic JP, Armstrong E, Baghaei F, Dalsgaard-Nielsen J,Hillarp A, Holme PA, Holmstrom M, Johnsson H, Joutsi-Korhonen L,Sandset PM. Practical viewpoints on the diagnosis and management ofheparin-induced thrombocytopenia.


Instruction: What is heparin-induced thrombocytopenia?

Output: type II

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is heparin-induced thrombocytopenia?. ### Response: type II.


Instruction: What is Ray WZ, Strom RG, Blackburn SL, Ashley WW, Sicard GA, Rich KM?

Output: Incidence of deep venous thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Ray WZ, Strom RG, Blackburn SL, Ashley WW, Sicard GA, Rich KM?. ### Response: Incidence of deep venous thrombosis.


Instruction: Doppler ultrasonographyscreening of poor-grade subarachnoid hemorrhage patients increases thediagnosis of deep venous thrombosis?

Output: 2008;30:889–892

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Doppler ultrasonographyscreening of poor-grade subarachnoid hemorrhage patients increases thediagnosis of deep venous thrombosis?. ### Response: 2008;30:889–892.


Instruction: Neurol Res. 2008;30:889–892.

Output: deep venous thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Neurol Res. 2008;30:889–892.. ### Response: deep venous thrombosis.


Instruction: What are congenital arrhythmia susceptibility associated with?

Output: tions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are congenital arrhythmia susceptibility associated with?. ### Response: tions.


Instruction: What is CALM1 encoding?

Output: calmodulin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CALM1 encoding?. ### Response: calmodulin.


Instruction: When did a mutation in CALM2 occur?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did a mutation in CALM2 occur?. ### Response: 2015.


Instruction: What causes ventricular tachycardia and sudden cardiac death?

Output: Mutations in calmodulin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What causes ventricular tachycardia and sudden cardiac death?. ### Response: Mutations in calmodulin.


Instruction: How many exomes did Paludan-Muller C, Ahlberg G, Ghouse J, et al. integrate?

Output: 60 000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many exomes did Paludan-Muller C, Ahlberg G, Ghouse J, et al. integrate?. ### Response: 60 000.


Instruction: What do mutations in calmodulin cause?

Output: ventricular tachycardia and sudden cardiac death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do mutations in calmodulin cause?. ### Response: ventricular tachycardia and sudden cardiac death.


Instruction: What is the role of cat-echolaminergic polymorphic ventricular tachycardia-associated variants?

Output: question

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of cat-echolaminergic polymorphic ventricular tachycardia-associated variants?. ### Response: question.


Instruction: What is Brugada Syndrome S7.9.1.3-1?

Output: risk stratification

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Brugada Syndrome S7.9.1.3-1?. ### Response: risk stratification.


Instruction: What is a meta-analysis of risk stratification of individuals with the Brugada electrocardiogram?

Output: Risk stratification of indi-viduals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a meta-analysis of risk stratification of individuals with the Brugada electrocardiogram?. ### Response: Risk stratification of indi-viduals.


Instruction: What is the name of the disease that affects young adults with Brugadas syndrome?

Output: Brugada syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease that affects young adults with Brugadas syndrome?. ### Response: Brugada syndrome.


Instruction: When was the J Electrocardiol.46:279–83?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Electrocardiol.46:279–83?. ### Response: 2013.


Instruction: What is the name of the registry used for risk stratification in Brugada syndrome?

Output: PRELUDE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the registry used for risk stratification in Brugada syndrome?. ### Response: PRELUDE.


Instruction: What is PRELUDE?

Output: PRogrammed ELectrical stimUlation preDictive valuE) registry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PRELUDE?. ### Response: PRogrammed ELectrical stimUlation preDictive valuE) registry.


Instruction: When was the J Am Coll Cardiol 59:37–45?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol 59:37–45?. ### Response: 2012.


Instruction: What is the name of the registry used to determine the long-term prognosis of patients with Brugada syndrome?

Output: FINGER Brugada syndrome registry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the registry used to determine the long-term prognosis of patients with Brugada syndrome?. ### Response: FINGER Brugada syndrome registry.


Instruction: What is a pooled analysis of programmed ventricular stimulation for risk stratification?

Output: Brugada electrocardiogram

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a pooled analysis of programmed ventricular stimulation for risk stratification?. ### Response: Brugada electrocardiogram.


Instruction: What is the Brugada syndrome: a pooled analysis?

Output: Programmed ventricular stimulation for risk stratification

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Brugada syndrome: a pooled analysis?. ### Response: Programmed ventricular stimulation for risk stratification.


Instruction: What was the Circulation. 2016:133:622–30?

Output: Programmed ventricular stimulation for risk stratification in the Brugada syndrome: a pooled analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the Circulation. 2016:133:622–30?. ### Response: Programmed ventricular stimulation for risk stratification in the Brugada syndrome: a pooled analysis.


Instruction: How long did it take to manage Brugadas syndrome?

Output: thirty-three-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take to manage Brugadas syndrome?. ### Response: thirty-three-year.


Instruction: Which class of antiarrhythmic drugs were used in management?

Output: class 1A

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which class of antiarrhythmic drugs were used in management?. ### Response: class 1A.


Instruction: What is a Brugada syndrome phe-notype elimination?

Output: epicardial substrate ablation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a Brugada syndrome phe-notype elimination?. ### Response: epicardial substrate ablation.


Instruction: What is an epicardial substrate ablation?

Output: Brugada syndrome phe-notype elimination

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an epicardial substrate ablation?. ### Response: Brugada syndrome phe-notype elimination.


Instruction: How is cath-eter ablation used to prevent ventricular fibrillation?

Output: over the anterior right ventricular outflow tract epi-cardium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is cath-eter ablation used to prevent ventricular fibrillation?. ### Response: over the anterior right ventricular outflow tract epi-cardium.


Instruction: Where is the anterior right ventricular outflow tract epi-cardium?

Output: Brugada syndrome by cath-eter ablation over

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the anterior right ventricular outflow tract epi-cardium?. ### Response: Brugada syndrome by cath-eter ablation over.


Instruction: What is the name of the anterior right ventricular outflow tract epi-cardium?

Output: S7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the anterior right ventricular outflow tract epi-cardium?. ### Response: S7.


Instruction: When did Circulation. 2011 issue 123:1270-9?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circulation. 2011 issue 123:1270-9?. ### Response: 2011.


Instruction: What did Sunsaneewitayakul B, Yao Y, Thamaree S, et al. use for ventricular fibrillation preven-tion?

Output: Endocardial mapping and catheter ablation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Sunsaneewitayakul B, Yao Y, Thamaree S, et al. use for ventricular fibrillation preven-tion?. ### Response: Endocardial mapping and catheter ablation.


Instruction: What type of substrate is used for catheter ablation of Brugada syndrome?

Output: epicar -dial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of substrate is used for catheter ablation of Brugada syndrome?. ### Response: epicar -dial.


Instruction: Heart Rhythm. 2016;13:2151-8.

Output: Suns

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Heart Rhythm. 2016;13:2151-8.. ### Response: Suns.


Instruction: How many consecutive complexes originating in the ventricles at a rate >100 bpm (cycle length: 600 cycles)?

Output: ≥ 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many consecutive complexes originating in the ventricles at a rate >100 bpm (cycle length: 600 cycles)?. ### Response: ≥ 3.


Instruction: When was Circulation. 2018;138:e272–e391?

Output: September 25, 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Circulation. 2018;138:e272–e391?. ### Response: September 25, 2018.


Instruction: What is the rate of the ventricles at a rate >100 bpm?

Output: ≥ 3 consecutive complexes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the rate of the ventricles at a rate >100 bpm?. ### Response: ≥ 3 consecutive complexes.


Instruction: How long is the cycle length?

Output: <600 ms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the cycle length?. ### Response: <600 ms.


Instruction: What type of VT is requiring termination due to hemodynamic compromise in 30 s?

Output: Sustained

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of VT is requiring termination due to hemodynamic compromise in 30 s?. ### Response: Sustained.


Instruction: What is VT with a beat-to-beat alternation in the QRS frontal plane axis often seen in the setting of digitalis toxicity or catecholaminergic polymorphic VT?

Output: Bidirectional

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is VT with a beat-to-beat alternation in the QRS frontal plane axis often seen in the setting of digitalis toxicity or catecholaminergic polymorphic VT?. ### Response: Bidirectional.


Instruction: What type of VT occurs in the setting of a long QT interval?

Output: polymorphic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of VT occurs in the setting of a long QT interval?. ### Response: polymorphic.


Instruction: Torsades de pointes is characterized by a waxing and waning QRS amplitude?

Output: esS2.2.2-2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Torsades de pointes is characterized by a waxing and waning QRS amplitude?. ### Response: esS2.2.2-2.


Instruction: What may present with salvos of NSVT?

Output: esS2.2.2-2Torsades de pointes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may present with salvos of NSVT?. ### Response: esS2.2.2-2Torsades de pointes.


Instruction: What may not always be seen?

Output: The twisting of the points

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may not always be seen?. ### Response: The twisting of the points.


Instruction: Torsades de pointes can result from what?

Output: bradycardia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Torsades de pointes can result from what?. ### Response: bradycardia.


Instruction: What can result from bradycardia?

Output: Torsades de pointes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can result from bradycardia?. ### Response: Torsades de pointes.


Instruction: What type of AV block leads to a long-short sequence initiating torsades de pointes?

Output: high-grade

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of AV block leads to a long-short sequence initiating torsades de pointes?. ### Response: high-grade.


Instruction: What is ventricular fibrillationS2.2.2-2Rapid, gross irregular electrical activity with marked variability in electrocardiographic waveform?

Output: ventricular rate usually >300 bpm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ventricular fibrillationS2.2.2-2Rapid, gross irregular electrical activity with marked variability in electrocardiographic waveform?. ### Response: ventricular rate usually >300 bpm.


Instruction: What is sudden cardiac arrest?

Output: sudden cessation of cardiac activity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is sudden cardiac arrest?. ### Response: sudden cessation of cardiac activity.


Instruction: What is presumed to be of cardiac etiology unless it is known or likely to have been caused by trauma, drowning, respiratory failure or asphyxia, electrocution, or drug overdose?

Output: An arrest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is presumed to be of cardiac etiology unless it is known or likely to have been caused by trauma, drowning, respiratory failure or asphyxia, electrocution, or drug overdose?. ### Response: An arrest.


Instruction: What is a noncardiac cause of death?

Output: drug overdose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a noncardiac cause of death?. ### Response: drug overdose.


Instruction: What is the term for sudden and unexpected death within an hour of the onset of symptoms or within 24 h of being asymptomatic?

Output: Sudden cardiac death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for sudden and unexpected death within an hour of the onset of symptoms or within 24 h of being asymptomatic?. ### Response: Sudden cardiac death.


Instruction: What is asymptomatic and presumably due to a cardiac arrhythmia or hemodynamic catastrophe?

Output: Sudden cardiac death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is asymptomatic and presumably due to a cardiac arrhythmia or hemodynamic catastrophe?. ### Response: Sudden cardiac death.


Instruction: What is the state of cardiac electrical instability defined by 3 episodes of sustained VT, VF, or appropriate shocks from an ICD within 24 h?

Output: VT/VF storm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the state of cardiac electrical instability defined by 3 episodes of sustained VT, VF, or appropriate shocks from an ICD within 24 h?. ### Response: VT/VF storm.


Instruction: What is the name of the cardioverter-defibrillator after acute myocardial infarction?

Output: Defibrillator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the cardioverter-defibrillator after acute myocardial infarction?. ### Response: Defibrillator.


Instruction: When did Steinbeck G, Andresen D, Seidl K, et al. implantation of a defi-brilliantator?

Output: early after myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Steinbeck G, Andresen D, Seidl K, et al. implantation of a defi-brilliantator?. ### Response: early after myocardial infarction.


Instruction: What was the N Engl J Med. 2009?

Output: 361:1427–36.589

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the N Engl J Med. 2009?. ### Response: 361:1427–36.589.


Instruction: What is an example of a defi-brillator in patients with myocardial infarction?

Output: Amiodarone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a defi-brillator in patients with myocardial infarction?. ### Response: Amiodarone.


Instruction: What is the name of the device that can be implanted for congestive heart failure?

Output: Amiodarone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the device that can be implanted for congestive heart failure?. ### Response: Amiodarone.


Instruction: In what year did N Engl J Med issue 352:2146.591?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did N Engl J Med issue 352:2146.591?. ### Response: 2005.


Instruction: How long did the follow-up study of the Multicenter Automatic Defibrillator Im-plantation Trial II last?

Output: 8-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the follow-up study of the Multicenter Automatic Defibrillator Im-plantation Trial II last?. ### Response: 8-year.


Instruction: What is the name of the study that showed the long-term benefit of primary prevention with an implantable cardioverter-defibrilator?

Output: Multicenter Automatic Defibrillator Im-plantation Trial II

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that showed the long-term benefit of primary prevention with an implantable cardioverter-defibrilator?. ### Response: Multicenter Automatic Defibrillator Im-plantation Trial II.


Instruction: What is the MEGA Study?

Output: a pro-spective randomised controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the MEGA Study?. ### Response: a pro-spective randomised controlled trial.


Instruction: What is pravastatin used for in Japan?

Output: diovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is pravastatin used for in Japan?. ### Response: diovascular disease.


Instruction: When was the REAL-CAD study released?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the REAL-CAD study released?. ### Response: April 28, 2023.


Instruction: What is the name of the CHARISMA Investigators?

Output: TRITON-TIMI38 Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the CHARISMA Investigators?. ### Response: TRITON-TIMI38 Investigators.


Instruction: What is another name for a patient with prior myocardial infarction, stroke, or symptomatic peripheral arterial disease?

Output: CHARISMAtrial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for a patient with prior myocardial infarction, stroke, or symptomatic peripheral arterial disease?. ### Response: CHARISMAtrial.


Instruction: When was the J Am Coll Cardiol 49:1982–1988.113?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol 49:1982–1988.113?. ### Response: 2007.


Instruction: What is the difference between prasugrel and clopidogrel in patients with acutecoronary syndromes?

Output: Ticagrelor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between prasugrel and clopidogrel in patients with acutecoronary syndromes?. ### Response: Ticagrelor.


Instruction: What year was Cardiol. 2007:49:1982–1988.113?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was Cardiol. 2007:49:1982–1988.113?. ### Response: 2008.


Instruction: What is the difference between ticagrelor and clopidogrel in patients with acute coronary syndromes?

Output: Prasugrel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between ticagrelor and clopidogrel in patients with acute coronary syndromes?. ### Response: Prasugrel.


Instruction: When was the Engl J Med 357:2001-2015.114 published?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Engl J Med 357:2001-2015.114 published?. ### Response: 2007.


Instruction: What is clopidogrel used for?

Output: acute coronary syndromes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is clopidogrel used for?. ### Response: acute coronary syndromes.


Instruction: What is the name of the collaborative meta-analysis of randomised trials of antiplatelet trials?

Output: Antithrombotic Trialists’ Collaboration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the collaborative meta-analysis of randomised trials of antiplatelet trials?. ### Response: Antithrombotic Trialists’ Collaboration.


Instruction: What is the name of a collaborative meta-analysis of trials of antiplatelet therapy for prevention of death, myo-cardial infarction, and stroke in high risk patients?

Output: Antithrombotic Trialists’ Collaboration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of a collaborative meta-analysis of trials of antiplatelet therapy for prevention of death, myo-cardial infarction, and stroke in high risk patients?. ### Response: Antithrombotic Trialists’ Collaboration.


Instruction: What was a randomised, blinded, trial of clopi-dogrel versus aspirin?

Output: CAPRIE Steering Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a randomised, blinded, trial of clopi-dogrel versus aspirin?. ### Response: CAPRIE Steering Committee.


Instruction: What is the difference between clopi-dogrel and aspirin in patients at risk of ischaemic events?

Output: aspirin doseand clopidogrel with thrombosis and bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between clopi-dogrel and aspirin in patients at risk of ischaemic events?. ### Response: aspirin doseand clopidogrel with thrombosis and bleeding.


Instruction: What is CAPRIE?

Output: A randomised, blinded, trial of clopi-dogrel versus aspirin in patients at risk of ischaemic events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CAPRIE?. ### Response: A randomised, blinded, trial of clopi-dogrel versus aspirin in patients at risk of ischaemic events.


Instruction: How many patients with acute myocardial infarction were treated with clopidogrel?

Output: 45,852

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with acute myocardial infarction were treated with clopidogrel?. ### Response: 45,852.


Instruction: How many patients with acute myocardial infarction were treated with aspirin?

Output: 45,852

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with acute myocardial infarction were treated with aspirin?. ### Response: 45,852.


Instruction: What is the name of the randomised placebo-controlled trial?

Output: TRITON-TIMI38 Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised placebo-controlled trial?. ### Response: TRITON-TIMI38 Investigators.


Instruction: When was the Lancet 366:1607-1621.119 published?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Lancet 366:1607-1621.119 published?. ### Response: 2005.


Instruction: What is a diabetic population with de novo coronaryartery lesions?

Output: Long-term outcomes by clopidogrelduration and stent type

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a diabetic population with de novo coronaryartery lesions?. ### Response: Long-term outcomes by clopidogrelduration and stent type.


Instruction: What is the name of the 8th edition of AmericanCollege of Chest Physicians Evidence-Based Clinical PracticeGuidelines?

Output: Antiplatelet drugs: AmericanCollege of Chest Physicians Evidence-Based Clinical Pract iceGuidelines (8th Edition). Chest. 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 8th edition of AmericanCollege of Chest Physicians Evidence-Based Clinical PracticeGuidelines?. ### Response: Antiplatelet drugs: AmericanCollege of Chest Physicians Evidence-Based Clinical Pract iceGuidelines (8th Edition). Chest. 2008.


Instruction: What does aspirin do to prevent cardiovascular disease?

Output: the association of aspirin doseand clopidogrel with thrombosis and bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does aspirin do to prevent cardiovascular disease?. ### Response: the association of aspirin doseand clopidogrel with thrombosis and bleeding.


Instruction: What does clopidogrel do to thrombosis and bleeding?

Output: association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does clopidogrel do to thrombosis and bleeding?. ### Response: association.


Instruction: How many patients were enrolled in a randomized controlled trial of aspirin?

Output: 192,036

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were enrolled in a randomized controlled trial of aspirin?. ### Response: 192,036.


Instruction: What is the name of the study that examined the risk of bleeding complications in 192,036 patients?

Output: 31 randomized controlledtrials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined the risk of bleeding complications in 192,036 patients?. ### Response: 31 randomized controlledtrials.


Instruction: What are the most commonly prescribed agents for hyperlipidemia?

Output: Statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the most commonly prescribed agents for hyperlipidemia?. ### Response: Statins.


Instruction: What have statins been shown to improve?

Output: survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have statins been shown to improve?. ### Response: survival.


Instruction: What has been shown to improve survival and reduce the risks of adverse car -diovascular events across a wide range of cholesterol levels?

Output: Statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been shown to improve survival and reduce the risks of adverse car -diovascular events across a wide range of cholesterol levels?. ### Response: Statins.


Instruction: Statins also reduce the progression of native artery atheroscle-rosis.

Output: 77,80–82

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Statins also reduce the progression of native artery atheroscle-rosis.. ### Response: 77,80–82.


Instruction: What have statins been demonstrated to inhibit the development of?

Output: saphe-nous vein graft disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have statins been demonstrated to inhibit the development of?. ### Response: saphe-nous vein graft disease.


Instruction: What has been shown to inhibit the development of saphenous vein graft disease?

Output: statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been shown to inhibit the development of saphenous vein graft disease?. ### Response: statins.


Instruction: What have statins reduced by reducing neointimal formation and smooth muscle proliferation?

Output: saphe-nous vein graft disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have statins reduced by reducing neointimal formation and smooth muscle proliferation?. ### Response: saphe-nous vein graft disease.


Instruction: How many patients had previously undergone CABG 1?

Output: 1351

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had previously undergone CABG 1?. ### Response: 1351.


Instruction: How many patients underwent CABG 1 to 11 years earlier?

Output: 1351

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients underwent CABG 1 to 11 years earlier?. ### Response: 1351.


Instruction: What were the patients randomized to after the CABG Trial?

Output: aggres-sive cholesterol reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the patients randomized to after the CABG Trial?. ### Response: aggres-sive cholesterol reduction.


Instruction: How much lovastatin did the patients receive?

Output: 40 to 80 mg daily

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much lovastatin did the patients receive?. ### Response: 40 to 80 mg daily.


Instruction: What is the daily dose of lovastatin?

Output: 2.5 to 5 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the daily dose of lovastatin?. ### Response: 2.5 to 5 mg.


Instruction: What was the mean LDL level of patients who received aggressive treatment?

Output: 93 to 97 mg/dL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean LDL level of patients who received aggressive treatment?. ### Response: 93 to 97 mg/dL.


Instruction: How long after study initiation did angiography demonstrate the reduction in LDL levels?

Output: ≈4 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after study initiation did angiography demonstrate the reduction in LDL levels?. ### Response: ≈4 years.


Instruction: How long after study initiation did angiography show that aggressive cholesterol reduction lowered the incidence of new vein graft occlusions?

Output: ≈4 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after study initiation did angiography show that aggressive cholesterol reduction lowered the incidence of new vein graft occlusions?. ### Response: ≈4 years.


Instruction: How much did aggressive reduction versus moderate reduction reduce the number of veins grafted with progression of atherosclerosis?

Output: 27% versus 39%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much did aggressive reduction versus moderate reduction reduce the number of veins grafted with progression of atherosclerosis?. ### Response: 27% versus 39%,.


Instruction: What was the difference between aggressive reduction and moderate reduction?

Output: 39%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the difference between aggressive reduction and moderate reduction?. ### Response: 39%,.


Instruction: How much reduction in the need for repeat revascularization was associated with the aggressive treatment approach?

Output: 30%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much reduction in the need for repeat revascularization was associated with the aggressive treatment approach?. ### Response: 30%.


Instruction: What did the post-CABG trial show in terms of adverse cardiovascular events?

Output: reduced both cardiovascular events and the progression of atherosclerosis in native coronary arter -ies and saphenous vein grafts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the post-CABG trial show in terms of adverse cardiovascular events?. ### Response: reduced both cardiovascular events and the progression of atherosclerosis in native coronary arter -ies and saphenous vein grafts.


Instruction: What did the Post-CABG trial show reduced both cardiovascular events and the progression of atherosclerosis in native coronary arteries and saphenous vein grafts?

Output: aggressive lowering of LDL to <100 mg/dL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Post-CABG trial show reduced both cardiovascular events and the progression of atherosclerosis in native coronary arteries and saphenous vein grafts?. ### Response: aggressive lowering of LDL to <100 mg/dL.


Instruction: What has been confirmed in several other randomized trials?

Output: The importance of postoperative LDL reduction with statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been confirmed in several other randomized trials?. ### Response: The importance of postoperative LDL reduction with statins.


Instruction: What has been confirmed in several other randomized and observational studies in the cardiac surgery literature?

Output: The importance of postoperative LDL reduction with statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been confirmed in several other randomized and observational studies in the cardiac surgery literature?. ### Response: The importance of postoperative LDL reduction with statins.


Instruction: What did a small, controlled trial published in 1999?

Output: statin treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a small, controlled trial published in 1999?. ### Response: statin treatment.


Instruction: How long did statin treatment continue for after CABG reduced the risk of MI?

Output: 1 year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did statin treatment continue for after CABG reduced the risk of MI?. ### Response: 1 year.


Instruction: What was reduced in the perioperative period?

Output: risk of MI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was reduced in the perioperative period?. ### Response: risk of MI.


Instruction: What was the risk of MI during the first year after CABG?

Output: 0% ver -sus 19%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk of MI during the first year after CABG?. ### Response: 0% ver -sus 19%,.


Instruction: How many patients received statin treatment within 1 month of CABG in a cohort study?

Output: 7503

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients received statin treatment within 1 month of CABG in a cohort study?. ### Response: 7503.


Instruction: How many patients had statin treatment within 1 month of CABG?

Output: 7503

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had statin treatment within 1 month of CABG?. ### Response: 7503.


Instruction: What is the VA/DoD Clinical Practice Guideline for the Diagnosis and Management of Hypertension in the Primary Care Setting?

Output: Page 26 of 134 A. Screening , Diagnosis, and Monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for the Diagnosis and Management of Hypertension in the Primary Care Setting?. ### Response: Page 26 of 134 A. Screening , Diagnosis, and Monitoring.


Instruction: What is Screening Recommendation 1?

Output: We recommend screening adults for elevated blood pressure periodically

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Screening Recommendation 1?. ### Response: We recommend screening adults for elevated blood pressure periodically.


Instruction: What does the USPSTF believe the benefits of blood pressure screening outweigh?

Output: any risks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the USPSTF believe the benefits of blood pressure screening outweigh?. ### Response: any risks.


Instruction: What is the reason for a periodic blood pressure check?

Output: increasing age is related to greater incidence of HTN, and because lifetime risk of developing HTN is so high

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the reason for a periodic blood pressure check?. ### Response: increasing age is related to greater incidence of HTN, and because lifetime risk of developing HTN is so high.


Instruction: What do the benefits of blood pressure screening far outweigh any risks?

Output: The risk for cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do the benefits of blood pressure screening far outweigh any risks?. ### Response: The risk for cardiovascular events.


Instruction: The risk for cardiovascular events and the potential benefit from screening and subsequent treatment of HTN depend on the degree and duration of what?

Output: blood pressure elevation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The risk for cardiovascular events and the potential benefit from screening and subsequent treatment of HTN depend on the degree and duration of what?. ### Response: blood pressure elevation.


Instruction: What are some other cardiovascular risk factors?

Output: age, gender, lipid disorders, smoking, and diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some other cardiovascular risk factors?. ### Response: age, gender, lipid disorders, smoking, and diabetes.


Instruction: What is the degree and duration of blood pressure elevation before screening?

Output: unknown

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the degree and duration of blood pressure elevation before screening?. ### Response: unknown.


Instruction: Who would benefit most from detection and treatment of HTN?

Output: normotensive adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who would benefit most from detection and treatment of HTN?. ### Response: normotensive adults.


Instruction: What would need to target individuals with other cardiovascular risk factors?

Output: selective screening

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would need to target individuals with other cardiovascular risk factors?. ### Response: selective screening.


Instruction: What did the 2015 update from the USPSTF conclude did not need updating?

Output: the indirect evidence path for HTN screening

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the 2015 update from the USPSTF conclude did not need updating?. ### Response: the indirect evidence path for HTN screening.


Instruction: What does not need updating?

Output: the indirect evidence path for HTN screening

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not need updating?. ### Response: the indirect evidence path for HTN screening.


Instruction: What can be improved for patients who are screened?

Output: estimates of the potential benefit of t reatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be improved for patients who are screened?. ### Response: estimates of the potential benefit of t reatment.


Instruction: How can the potential benefit of t reatment be improved?

Output: both by carefully measuring the degree of blood pressure elevation and by assessing the contribution of other risk factors to global cardiovascular risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can the potential benefit of t reatment be improved?. ### Response: both by carefully measuring the degree of blood pressure elevation and by assessing the contribution of other risk factors to global cardiovascular risk.


Instruction: What is the risk of developing HTN for octogenarians?

Output: 90%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of developing HTN for octogenarians?. ### Response: 90%.


Instruction: What does increasing age have to do with greater incidence of HTN?

Output: lifetime risk of developing HTN is so high

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does increasing age have to do with greater incidence of HTN?. ### Response: lifetime risk of developing HTN is so high.


Instruction: Why is it important to screen for HTN periodically?

Output: increasing age is related to greater incidence of HTN, and because lifetime risk of developing HTN is so high

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is it important to screen for HTN periodically?. ### Response: increasing age is related to greater incidence of HTN, and because lifetime risk of developing HTN is so high.


Instruction: How many separate guidelines make recommendations for rescreening?

Output: Multiple

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many separate guidelines make recommendations for rescreening?. ### Response: Multiple.


Instruction: How many studies were identified in a 2015 SR by the USPSTF?

Output: 40

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were identified in a 2015 SR by the USPSTF?. ### Response: 40.


Instruction: What are recommendations for for rescreening intervals?

Output: Multiple separate guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are recommendations for for rescreening intervals?. ### Response: Multiple separate guidelines.


Instruction: How many studies did the USPSTF identify?

Output: 40

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies did the USPSTF identify?. ### Response: 40.


Instruction: What was the definition of blood pressure 140/90 mm Hg using office blood pressure measurements?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the definition of blood pressure 140/90 mm Hg using office blood pressure measurements?. ### Response: <.


Instruction: How many highly variable estimates of incident HTN were there?

Output: 2.2 -4.4%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many highly variable estimates of incident HTN were there?. ### Response: 2.2 -4.4%.


Instruction: How much value is there for screening normotensive adults?

Output: 2.2 -4.4% at one -year interval and 2.1 -28.4% at five -year intervals.  This confirms the recommendation that there is value

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much value is there for screening normotensive adults?. ### Response: 2.2 -4.4% at one -year interval and 2.1 -28.4% at five -year intervals.  This confirms the recommendation that there is value.


Instruction: What percentage is there at one -year intervals?

Output: 2.2 -4.4%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage is there at one -year intervals?. ### Response: 2.2 -4.4%.


Instruction: How much at five year intervals is there?

Output: 2.1 -28.4%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much at five year intervals is there?. ### Response: 2.1 -28.4%.


Instruction: Why is this recommendation not reviewed?

Output: the Work Group did not systematically review evidence related to this recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is this recommendation not reviewed?. ### Response: the Work Group did not systematically review evidence related to this recommendation.


Instruction: What did the Work Group not systematically review?

Output: evidence related to this recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Work Group not systematically review?. ### Response: evidence related to this recommendation.


Instruction: What was the assessment of the quality of the evidence put forth in the 2014 VA/DoD HTN CPG?

Output: confidence in the quality of the evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the assessment of the quality of the evidence put forth in the 2014 VA/DoD HTN CPG?. ### Response: confidence in the quality of the evidence.


Instruction: What is the Work Group’s confidence in the quality of the evidence?

Output: Based on the assessment of the quality of the evidence put forth in the 2014 VA/DoD HTN CPG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Work Group’s confidence in the quality of the evidence?. ### Response: Based on the assessment of the quality of the evidence put forth in the 2014 VA/DoD HTN CPG.


Instruction: What is the annualized risk of major bleeding?

Output: $6.5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the annualized risk of major bleeding?. ### Response: $6.5%.


Instruction: What was the anticoagulant in all studies that compared differenttime-limited durations of therapy?

Output: Apixaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the anticoagulant in all studies that compared differenttime-limited durations of therapy?. ### Response: Apixaban.


Instruction: What was the anticoagulant when we were making our AT9 recommendations?

Output: VKA therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the anticoagulant when we were making our AT9 recommendations?. ### Response: VKA therapy.


Instruction: What did we compare extended therapy with stoppingtreatment at 3 months?

Output: anticoagulant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did we compare extended therapy with stoppingtreatment at 3 months?. ### Response: anticoagulant.


Instruction: How many additional studies have compared two time-limited durations ofanticoagulant therapy?

Output: Two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many additional studies have compared two time-limited durations ofanticoagulant therapy?. ### Response: Two.


Instruction: What was the target INR 2.5 for PE who had completed 6 months of VKAtherapy?

Output: Extended Duration of OralAnticoagulant Therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the target INR 2.5 for PE who had completed 6 months of VKAtherapy?. ### Response: Extended Duration of OralAnticoagulant Therapy.


Instruction: What did PADIS study randomized patients to?

Output: Extended Duration of OralAnticoagulant Therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did PADIS study randomized patients to?. ### Response: Extended Duration of OralAnticoagulant Therapy.


Instruction: What is GRADE?

Output: Quality of theEvidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is GRADE?. ### Response: Quality of theEvidence.


Instruction: What is the risk of placebo with Rivaroxaban?

Output: 0/590 (0%);

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of placebo with Rivaroxaban?. ### Response: 0/590 (0%);.


Instruction: Why is the basis of the study not estimable?

Output: riskof bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is the basis of the study not estimable?. ### Response: riskof bias.


Instruction: What is the basis for the assumed risk?

Output: the median control group risk across studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the basis for the assumed risk?. ### Response: the median control group risk across studies.


Instruction: What is provided in the footnotes?

Output: The basis for the assumed risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is provided in the footnotes?. ### Response: The basis for the assumed risk.


Instruction: The corresponding risk is based on what?

Output: the assumed risk in the comparison group and the relative effect of the intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The corresponding risk is based on what?. ### Response: the assumed risk in the comparison group and the relative effect of the intervention.


Instruction: What is the 95% CI of the intervention?

Output: Relative Effect(95% CI)Anticipated Absolute EffectsRisk withPlaceboRisk Difference withApixaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 95% CI of the intervention?. ### Response: Relative Effect(95% CI)Anticipated Absolute EffectsRisk withPlaceboRisk Difference withApixaban.