Instruction: When was the REPLACE-2 randomized trial conducted?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the REPLACE-2 randomized trial conducted?. ### Response: 2004.


Instruction: What is the difference between clopidogrel and aspirin for prevention of atherothrombotic events?

Output: aspirin alone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between clopidogrel and aspirin for prevention of atherothrombotic events?. ### Response: aspirin alone.


Instruction: What is the difference between early invasive and selectively invasive management for acute coronary syndromes?

Output: delayed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between early invasive and selectively invasive management for acute coronary syndromes?. ### Response: delayed.


Instruction: When did the N Engl J Med issue 353:1095-104.112.

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the N Engl J Med issue 353:1095-104.112.. ### Response: 2005.


Instruction: What was the result of the Veterans Administration Cooperative Study?

Output: Comparison of medical and surgicaltreatment for unstable angina pectoris

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the result of the Veterans Administration Cooperative Study?. ### Response: Comparison of medical and surgicaltreatment for unstable angina pectoris.


Instruction: What is a risk stratification after myocardialinfarction?

Output: Clopidogrel resistance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk stratification after myocardialinfarction?. ### Response: Clopidogrel resistance.


Instruction: What is the VA cooperative ran-domized study of?

Output: surgery for coronary arterial occlusive disease II

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA cooperative ran-domized study of?. ### Response: surgery for coronary arterial occlusive disease II.


Instruction: What is clopidogrel loadingdose based on?

Output: platelet reactivity monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is clopidogrel loadingdose based on?. ### Response: platelet reactivity monitoring.


Instruction: What is the name of the drug used to prevent stent thrombosis?

Output: clopidogrel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used to prevent stent thrombosis?. ### Response: clopidogrel.


Instruction: When was the Am J Cardiol 103:5–10.116 published?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Am J Cardiol 103:5–10.116 published?. ### Response: 2009.


Instruction: What do plateletfunction tests predict in patients undergoing coronary stent implantation?

Output: clinical outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do plateletfunction tests predict in patients undergoing coronary stent implantation?. ### Response: clinical outcome.


Instruction: What is a point-of-care assay for predicting cardiovascular death and nonfatal myocardial infarction in acute coronary syndrome patients?

Output: a 12-month follow-up

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a point-of-care assay for predicting cardiovascular death and nonfatal myocardial infarction in acute coronary syndrome patients?. ### Response: a 12-month follow-up.


Instruction: What is reactivity to ADP detected by a point-of-care assay?

Output: residual platelet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reactivity to ADP detected by a point-of-care assay?. ### Response: residual platelet.


Instruction: What is asso-ciated with increased risk of recurrent atherothrombotic events in patientswith acute myocardial infarction?

Output: Clopidogrel resistance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is asso-ciated with increased risk of recurrent atherothrombotic events in patientswith acute myocardial infarction?. ### Response: Clopidogrel resistance.


Instruction: How many trials of CABG with balloon angioplasty were conducted?

Output: 6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many trials of CABG with balloon angioplasty were conducted?. ### Response: 6.


Instruction: How many studies of BMSimplantation were performed?

Output: 4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies of BMSimplantation were performed?. ### Response: 4.


Instruction: What was the mortality rate after randomization?

Output: 5.9 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mortality rate after randomization?. ### Response: 5.9 years.


Instruction: Why were repeat revascularization and angina more frequent in patients treated with balloon angioplasty?

Output: 4times higher after DES implantation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why were repeat revascularization and angina more frequent in patients treated with balloon angioplasty?. ### Response: 4times higher after DES implantation.


Instruction: What were more frequent in those treated with balloon angioplasty or BMS implantation?

Output: Repeat revascularizationand angina

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were more frequent in those treated with balloon angioplasty or BMS implantation?. ### Response: Repeat revascularizationand angina.


Instruction: What was associated with better outcomes in patients with diabetes mellitus and in those /H1102265 years of age?

Output: CABG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with better outcomes in patients with diabetes mellitus and in those /H1102265 years of age?. ### Response: CABG.


Instruction: What was not influenced by other patient charac-teristics?

Output: the relative outcomes ofCABG and PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not influenced by other patient charac-teristics?. ### Response: the relative outcomes ofCABG and PCI.


Instruction: What was limited in several ways?

Output: meta-analysis and systematic re-view1079,1080 comparing CABG and balloon angioplasty orBMS implantation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was limited in several ways?. ### Response: meta-analysis and systematic re-view1079,1080 comparing CABG and balloon angioplasty orBMS implantation.


Instruction: Many trials did not report what?

Output: outcomes for other importantpatient subsets

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Many trials did not report what?. ### Response: outcomes for other importantpatient subsets.


Instruction: What subset of patients have important outcomes?

Output: /H110215% to 10%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What subset of patients have important outcomes?. ### Response: /H110215% to 10%).


Instruction: What is insufficient to determine if race, obesity, renal dysfunc-tion, PAD, or previous coronary revascularization af-fected the comparative outcomes of CABG and PCI?

Output: the available data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is insufficient to determine if race, obesity, renal dysfunc-tion, PAD, or previous coronary revascularization af-fected the comparative outcomes of CABG and PCI?. ### Response: the available data.


Instruction: Most of the patients enrolled in these trials were male?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Most of the patients enrolled in these trials were male?. ### Response: 2.


Instruction: What type of CAD and normal LVsystolic function were most screened for?

Output: 1- or 2-vessel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of CAD and normal LVsystolic function were most screened for?. ### Response: 1- or 2-vessel.


Instruction: What percentage of screened patients had 1- or 2-vessel CAD?

Output: /H110215% to 10%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of screened patients had 1- or 2-vessel CAD?. ### Response: /H110215% to 10%).


Instruction: How many patients were enrolled in these trials?

Output: 1800

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were enrolled in these trials?. ### Response: 1800.


Instruction: What percentage of patients were screened?

Output: /H110215% to 10%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients were screened?. ### Response: /H110215% to 10%).


Instruction: What was not considered for randomization?

Output: most screened patientswith 1-vessel CAD and many with 3-vessel CAD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not considered for randomization?. ### Response: most screened patientswith 1-vessel CAD and many with 3-vessel CAD.


Instruction: How many observational studies have been published comparingCABG and DESA?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many observational studies have been published comparingCABG and DESA?. ### Response: 1.


Instruction: How long were most of the studies comparing CABG and DES?

Output: 12 to 24 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long were most of the studies comparing CABG and DES?. ### Response: 12 to 24 months.


Instruction: How many patients with multivessel CAD treated with CABG or DES had similar incidences of death andMI?

Output: 24 268

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with multivessel CAD treated with CABG or DES had similar incidences of death andMI?. ### Response: 24 268.


Instruction: What was the frequency with which repeat revascularization was performed?

Output: more frequently

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the frequency with which repeat revascularization was performed?. ### Response: more frequently.


Instruction: How many procedures were performed after DES implantation?

Output: 28.0%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many procedures were performed after DES implantation?. ### Response: 28.0%.


Instruction: How many times higher was the frequency with which repeat revascularization was performed?

Output: 4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many times higher was the frequency with which repeat revascularization was performed?. ### Response: 4.


Instruction: What trial randomly assigned 1800 patients?

Output: SYNTAX

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What trial randomly assigned 1800 patients?. ### Response: SYNTAX.


Instruction: What percentage of CABG patients underwent DES implantation?

Output: 28.0%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of CABG patients underwent DES implantation?. ### Response: 28.0%.


Instruction: How many years after randomiza-tion did MACE occur?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many years after randomiza-tion did MACE occur?. ### Response: 3.


Instruction: What was the composite of death, stroke, MI, or repeat revascularization during 3 years?

Output: 949,950,980 MACE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the composite of death, stroke, MI, or repeat revascularization during 3 years?. ### Response: 949,950,980 MACE.


Instruction: What was more likely to occur with DESimplantation?

Output: repeat revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was more likely to occur with DESimplantation?. ### Response: repeat revascularization.


Instruction: What is the SYNTAX score based on?

Output: location, severity, andextent of coronary stenoses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the SYNTAX score based on?. ### Response: location, severity, andextent of coronary stenoses.


Instruction: A low score indicates what?

Output: less

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A low score indicates what?. ### Response: less.


Instruction: What score indicates less coronary stenoses?

Output: low

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What score indicates less coronary stenoses?. ### Response: low.


Instruction: What does a low score indicate?

Output: less

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does a low score indicate?. ### Response: less.


Instruction: What is CARE-HF?

Output: Cardiac Resynchronization-Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CARE-HF?. ### Response: Cardiac Resynchronization-Heart Failure.


Instruction: What is the effect of cardiac resynchronization on morbidity and mortality in heart failure?

Output: prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of cardiac resynchronization on morbidity and mortality in heart failure?. ### Response: prevention.


Instruction: What is the name of the trial investigators of the MADIT-CRT trial?

Output: Foster E, Greenberg H, Higgins SL, Pfeffer MA, Solomon SD, Wilber D, Zareba W

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the trial investigators of the MADIT-CRT trial?. ### Response: Foster E, Greenberg H, Higgins SL, Pfeffer MA, Solomon SD, Wilber D, Zareba W.


Instruction: What is a potential benefit of Cardiac-resynchronization therapy for the prevention of heart failure events?

Output: morbidity and mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a potential benefit of Cardiac-resynchronization therapy for the prevention of heart failure events?. ### Response: morbidity and mortality.


Instruction: What does N Engl J Med. 2009:361:1329–1338?

Output: Cardiac-resynchronization therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does N Engl J Med. 2009:361:1329–1338?. ### Response: Cardiac-resynchronization therapy.


Instruction: What is the doi: 10.1056/NEJMoa0906431.

Output: N Engl J Med.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the doi: 10.1056/NEJMoa0906431.. ### Response: N Engl J Med..


Instruction: What does Resynchronization-Defibrillation for Ambulatory Heart Failure Trial Investigators do?

Output: Cardiac-resynchronization therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Resynchronization-Defibrillation for Ambulatory Heart Failure Trial Investigators do?. ### Response: Cardiac-resynchronization therapy.


Instruction: What is Cardiac-resynchronization therapy for mild-to-moderate heart failure?

Output: Resynchronization-Defibrillation for Ambulatory Heart Failure Trial Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Cardiac-resynchronization therapy for mild-to-moderate heart failure?. ### Response: Resynchronization-Defibrillation for Ambulatory Heart Failure Trial Investigators.


Instruction: When did N Engl J Med issue 363:2385-2395?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did N Engl J Med issue 363:2385-2395?. ### Response: 2010.


Instruction: How long does diabetes mellitus affect the outcomes of drug-eluting stents and coronary artery bypass grafting?

Output: five-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does diabetes mellitus affect the outcomes of drug-eluting stents and coronary artery bypass grafting?. ### Response: five-year.


Instruction: What is the name of the procedure that has been shown to have a positive effect on long term outcomes?

Output: drug-eluting stents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the procedure that has been shown to have a positive effect on long term outcomes?. ### Response: drug-eluting stents.


Instruction: When was the Am J Cardiol 109:1548-1557 published?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Am J Cardiol 109:1548-1557 published?. ### Response: 2012.


Instruction: What does grafting for multivessel coronary revascularization do?

Output: Influence of diabetes mellitus on long-term (five-year) outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does grafting for multivessel coronary revascularization do?. ### Response: Influence of diabetes mellitus on long-term (five-year) outcomes.


Instruction: What is the name of the committee that reports on the role of the International Expert Committee in diabetes care?

Output: International Expert Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the committee that reports on the role of the International Expert Committee in diabetes care?. ### Response: International Expert Committee.


Instruction: What does the International Expert Committee report on?

Output: the role of the A1C assay in the diagnosis of diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the International Expert Committee report on?. ### Response: the role of the A1C assay in the diagnosis of diabetes.


Instruction: What is the role of the A1C assay in the diagnosis of diabetes?

Output: International Expert Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of the A1C assay in the diagnosis of diabetes?. ### Response: International Expert Committee.


Instruction: Diabetes Care. 2009;32:1327–1334. 272.

Output: International Expert Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Diabetes Care. 2009;32:1327–1334. 272.. ### Response: International Expert Committee.


Instruction: What is the Society of Thoracic Surgeons Blood Glucose Guideline Task Force?

Output: blood glucose management during adult cardiac surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Society of Thoracic Surgeons Blood Glucose Guideline Task Force?. ### Response: blood glucose management during adult cardiac surgery.


Instruction: What practice guideline series does the society of thoracic surgeons have?

Output: blood glucose management during adult cardiac surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What practice guideline series does the society of thoracic surgeons have?. ### Response: blood glucose management during adult cardiac surgery.


Instruction: When is blood glucose management during adult cardiac surgery?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is blood glucose management during adult cardiac surgery?. ### Response: 2009.


Instruction: What is predictive of adverse out-comes after cardiovascular surgery?

Output: Blood glucose level

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is predictive of adverse out-comes after cardiovascular surgery?. ### Response: Blood glucose level.


Instruction: What does blood glucose level on postoperative day 1 do?

Output: predictive of adverse out-comes after cardiovascular surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does blood glucose level on postoperative day 1 do?. ### Response: predictive of adverse out-comes after cardiovascular surgery.


Instruction: Diabetes Metab. 2010;36:36–42. doi: 10.1016/j.diabet.2009.06.008. 274.

Output: Blood Glucose Guideline Task Force

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Diabetes Metab. 2010;36:36–42. doi: 10.1016/j.diabet.2009.06.008. 274.. ### Response: Blood Glucose Guideline Task Force.


Instruction: How does tight glycemic control in diabetic coronary artery bypass graft patients improve perioperative outcomes and decrease recurrent ischemic events?

Output: improves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does tight glycemic control in diabetic coronary artery bypass graft patients improve perioperative outcomes and decrease recurrent ischemic events?. ### Response: improves.


Instruction: Circulation. 2004;109:1497–1502. doi: 10.1161/01.CIR.0000121747.71054.79.

Output: 274

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation. 2004;109:1497–1502. doi: 10.1161/01.CIR.0000121747.71054.79.. ### Response: 274.


Instruction: What does candesartan have on mortality and morbidity inpatients with chronic heart failure?

Output: Effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does candesartan have on mortality and morbidity inpatients with chronic heart failure?. ### Response: Effects.


Instruction: What is the CHARM-Overall pro gramme?

Output: Effects of candesartan on mortality and mor bidity inpatients with chronic heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the CHARM-Overall pro gramme?. ### Response: Effects of candesartan on mortality and mor bidity inpatients with chronic heart failure.


Instruction: What year did Lancet publish a correction to Valsartan in Acute Myocardial Infarction Trial?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Lancet publish a correction to Valsartan in Acute Myocardial Infarction Trial?. ### Response: 2003.


Instruction: What is the name of the study that published the correction in 2009?

Output: Lancet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that published the correction in 2009?. ### Response: Lancet.


Instruction: What drug is used in acute myocardial infarction?

Output: Valsartan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug is used in acute myocardial infarction?. ### Response: Valsartan.


Instruction: What is the name of the drug used to treat acute heart failure?

Output: Valsartan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used to treat acute heart failure?. ### Response: Valsartan.


Instruction: When was the AHA/ACCF Secondary Prevention: 2011 Update 2471 released?

Output: May 1, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the AHA/ACCF Secondary Prevention: 2011 Update 2471 released?. ### Response: May 1, 2023.


Instruction: What did post hoc analyses from CORONA show?

Output: patients randomized to rosuvastatin with less advanced HF with reduced ejection fraction (low-est tertile of NT-proBNP) had a significant reduction in the primary outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did post hoc analyses from CORONA show?. ### Response: patients randomized to rosuvastatin with less advanced HF with reduced ejection fraction (low-est tertile of NT-proBNP) had a significant reduction in the primary outcome.


Instruction: What did patients randomized to rosuvastatin with less advanced HF with reduced ejection fraction have?

Output: a significant reduction in the primary outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did patients randomized to rosuvastatin with less advanced HF with reduced ejection fraction have?. ### Response: a significant reduction in the primary outcome.


Instruction: Which studies were notable?

Output: CORONA and GISSI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which studies were notable?. ### Response: CORONA and GISSI.


Instruction: What were the CORONA and GISSI studies notable for?

Output: high overall and cardiovascular mortality rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the CORONA and GISSI studies notable for?. ### Response: high overall and cardiovascular mortality rates.


Instruction: What was MI in a small minority?

Output: cardiovascular mortality rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was MI in a small minority?. ### Response: cardiovascular mortality rates.


Instruction: How much reduction in the risk of MI was found in the patient-level analysis?

Output: 19%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much reduction in the risk of MI was found in the patient-level analysis?. ### Response: 19%.


Instruction: How much was the risk of MI reduced with rosuvastatin in patients with ischemic HF?

Output: 19%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much was the risk of MI reduced with rosuvastatin in patients with ischemic HF?. ### Response: 19%.


Instruction: What was the ARR for patients with severe hypercholesterolemia?

Output: small.4.2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the ARR for patients with severe hypercholesterolemia?. ### Response: small.4.2.


Instruction: Where are references to studies that support recommendations summarized?

Output: Online Data Supplements 9 and 10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are references to studies that support recommendations summarized?. ### Response: Online Data Supplements 9 and 10.


Instruction: In patients 20 to 75 years of age with an LDL-C level of 190 mg/dL or higher, what is recommended?

Output: maximally tolerated statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients 20 to 75 years of age with an LDL-C level of 190 mg/dL or higher, what is recommended?. ### Response: maximally tolerated statin therapy.


Instruction: What is maximally tolerated statin therapy?

Output: ezetimibe therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is maximally tolerated statin therapy?. ### Response: ezetimibe therapy.


Instruction: What is statin therapy recommended for?

Output: 20 to 75 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is statin therapy recommended for?. ### Response: 20 to 75 years of age.


Instruction: What is the LDL-C level of patients 20 to 75 years of age?

Output: 190 mg/dL or higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the LDL-C level of patients 20 to 75 years of age?. ### Response: 190 mg/dL or higher.


Instruction: What is ezetimibe therapy reasonable for?

Output: In patients 20 to 75 years of age with an LDL-C level of 190 mg/dL or higher (≥4.9 mmol/L) who achieve less than a 50% reduction in LDL-C while receiving maximally tolerated statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ezetimibe therapy reasonable for?. ### Response: In patients 20 to 75 years of age with an LDL-C level of 190 mg/dL or higher (≥4.9 mmol/L) who achieve less than a 50% reduction in LDL-C while receiving maximally tolerated statin therapy.


Instruction: What is the baseline LDL-C level of 190 mg/dL or higher?

Output: ≥4.9 mmol/L

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the baseline LDL-C level of 190 mg/dL or higher?. ### Response: ≥4.9 mmol/L.


Instruction: How many mmol/L are patients 20 to 75 years of age with?

Output: ≥4.9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mmol/L are patients 20 to 75 years of age with?. ### Response: ≥4.9.


Instruction: How much reduction in LDL-C levels does LDL have?

Output: 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much reduction in LDL-C levels does LDL have?. ### Response: 50%.


Instruction: What are fasting triglycerides 300 mg/dL or lower?

Output: ≤3.4 mmol/L

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are fasting triglycerides 300 mg/dL or lower?. ### Response: ≤3.4 mmol/L.


Instruction: In patients 30 to 75 years of age with heterozygous FH and ezetimibe therapy, what may be considered?

Output: the addition of a PCSK9 inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients 30 to 75 years of age with heterozygous FH and ezetimibe therapy, what may be considered?. ### Response: the addition of a PCSK9 inhibitor.


Instruction: What may be considered in patients 40 to 75 years of age with a heterozygous FH?

Output: the addition of a PCSK9 inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered in patients 40 to 75 years of age with a heterozygous FH?. ### Response: the addition of a PCSK9 inhibitor.


Instruction: What is the LDL-C level of 100 mg/dL or higher?

Output: ≥2.6 mmol/L

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the LDL-C level of 100 mg/dL or higher?. ### Response: ≥2.6 mmol/L.


Instruction: When taking maximally tolerated statin and ezetimibe therapy, what might be considered?

Output: the addition of a PCSK9 inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When taking maximally tolerated statin and ezetimibe therapy, what might be considered?. ### Response: the addition of a PCSK9 inhibitor.


Instruction: What is the baseline LDL-C level in patients 40 to 75 years of age?

Output: 220 mg/dL or higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the baseline LDL-C level in patients 40 to 75 years of age?. ### Response: 220 mg/dL or higher.


Instruction: What may be added to a patient who receives maximally tolerated statin and ezetimibe therapy?

Output: PCSK9 inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be added to a patient who receives maximally tolerated statin and ezetimibe therapy?. ### Response: PCSK9 inhibitor.


Instruction: What may be considered in addition to ezetimibe therapy?

Output: PCSK9 inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered in addition to ezetimibe therapy?. ### Response: PCSK9 inhibitor.


Instruction: What is the value statement for PCSK9 inhibitors?

Output: Uncertain Value

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the value statement for PCSK9 inhibitors?. ### Response: Uncertain Value.


Instruction: Where can you find this information?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find this information?. ### Response: http://ahajournals.org.


Instruction: When was this information downloaded?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this information downloaded?. ### Response: April 28, 2023.


Instruction: How many consecutive patients with acute myocardial infarction were studied in a single centre retrospective analysis?

Output: 548

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many consecutive patients with acute myocardial infarction were studied in a single centre retrospective analysis?. ### Response: 548.


Instruction: How many consecutive patients with acute myocardial infarction were retrospectively analysed?

Output: 548

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many consecutive patients with acute myocardial infarction were retrospectively analysed?. ### Response: 548.


Instruction: When was the retrospective analysis of 548 consecutive patients released?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the retrospective analysis of 548 consecutive patients released?. ### Response: April 28, 2023.


Instruction: What are women more likely to have than men?

Output: hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are women more likely to have than men?. ### Response: hypertension.


Instruction: What may women have a higher risk of first stroke with hypertension?

Output: older women (mean age 63 years) with prehypertension had a 93%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may women have a higher risk of first stroke with hypertension?. ### Response: older women (mean age 63 years) with prehypertension had a 93%.


Instruction: What was the risk of stroke for women with BPs of 160/90 mm Hg?

Output: 4.89

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk of stroke for women with BPs of 160/90 mm Hg?. ### Response: 4.89.


Instruction: How did women with prehypertension have a 93% increased risk?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did women with prehypertension have a 93% increased risk?. ### Response: stroke.


Instruction: What age group had a 93% increased risk of stroke compared with normotensive women in the Women's Health Initiative cohort?

Output: older women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What age group had a 93% increased risk of stroke compared with normotensive women in the Women's Health Initiative cohort?. ### Response: older women.


Instruction: What does WHI mean?

Output: Women’s Health Initiative (WHI) cohort, which implies that early and sustained treatment of hypertension is critical

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does WHI mean?. ### Response: Women’s Health Initiative (WHI) cohort, which implies that early and sustained treatment of hypertension is critical.


Instruction: What has been studied extensively in Women?

Output: The effects of pharmacological intervention to lower BP and thereby reduce the risk of stroke on cardiovascular outcomes and surrogate cardiovascular end points

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been studied extensively in Women?. ### Response: The effects of pharmacological intervention to lower BP and thereby reduce the risk of stroke on cardiovascular outcomes and surrogate cardiovascular end points.


Instruction: Women have been well represented in large clinical trials of what?

Output: antihypertensive therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Women have been well represented in large clinical trials of what?. ### Response: antihypertensive therapy.


Instruction: What has no trials specifically examined?

Output: a differential effect of phar -macological BP treatment in men and women on stroke events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has no trials specifically examined?. ### Response: a differential effect of phar -macological BP treatment in men and women on stroke events.


Instruction: No studies have examined a differential effect of phar -macological BP treatment in men and women on stroke events?

Output: pertensive therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No studies have examined a differential effect of phar -macological BP treatment in men and women on stroke events?. ### Response: pertensive therapy.


Instruction: Post hoc analyses and meta-analyses of clinical trial data have not reported sex differences in response to what?

Output: treat-ment or stroke events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Post hoc analyses and meta-analyses of clinical trial data have not reported sex differences in response to what?. ### Response: treat-ment or stroke events.


Instruction: How much risk reduction in fatal and nonfatal cerebrovascu-lar events was associated with hypertension treatment in women?

Output: 38%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much risk reduction in fatal and nonfatal cerebrovascu-lar events was associated with hypertension treatment in women?. ### Response: 38%.


Instruction: How many large, randomized BP trials were analyzed?

Output: 31

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many large, randomized BP trials were analyzed?. ### Response: 31.


Instruction: What percentage of women treated for hypertension were white?

Output: 90%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of women treated for hypertension were white?. ### Response: 90%.


Instruction: What was the reduction of 25% in fatal and nonfatal cardiovascular events?

Output: Figure 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the reduction of 25% in fatal and nonfatal cardiovascular events?. ### Response: Figure 2.


Instruction: What is the female-male US stroke mortality ratio, 2009?

Output: 4.89; 95% CI, 3.79–6.32

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the female-male US stroke mortality ratio, 2009?. ### Response: 4.89; 95% CI, 3.79–6.32.


Instruction: Where was the data downloaded by on April 28, 2023?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where was the data downloaded by on April 28, 2023?. ### Response: http://ahajournals.org.


Instruction: What is agalactiae)Listeria monocytogenesAerobic Gram-negative bacilliNeisseria gonorrhoeaeChronic skin disorders, including recurrent infectionsS aureus-Hemolytic streptococciPoor dental health, dental procedures Viridans group StreptococciWhat is the name of the organism that causes alcoholism, cirrhosis?

Output: streptococci

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is agalactiae)Listeria monocytogenesAerobic Gram-negative bacilliNeisseria gonorrhoeaeChronic skin disorders, including recurrent infectionsS aureus-Hemolytic streptococciPoor dental health, dental procedures Viridans group StreptococciWhat is the name of the organism that causes alcoholism, cirrhosis?. ### Response: streptococci.


Instruction: How long does it take to place a prosthetic valve?

Output: ≤1 y

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take to place a prosthetic valve?. ### Response: ≤1 y.


Instruction: What is the name of the bacteria that causes mellitus S aureus-Hemolytic streptococciS pneumoniaeEarly (1 y) Prosthetic valve placement?

Output: P aeruginosaFungi

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the bacteria that causes mellitus S aureus-Hemolytic streptococciS pneumoniaeEarly (1 y) Prosthetic valve placement?. ### Response: P aeruginosaFungi.


Instruction: What does catheter ablation do for atrial fibrillation?

Output: use and cardioembolic risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does catheter ablation do for atrial fibrillation?. ### Response: use and cardioembolic risk.


Instruction: What does Eitel C, Koch J, Sommer P, et al. use of novel oral anticoagulants in a real-world cohort of patients undergo?

Output: catheter ablation of atrial fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Eitel C, Koch J, Sommer P, et al. use of novel oral anticoagulants in a real-world cohort of patients undergo?. ### Response: catheter ablation of atrial fibrillation.


Instruction: Euro-pace. 2013;15:1587–93.

Output: 22

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Euro-pace. 2013;15:1587–93.. ### Response: 22.


Instruction: What is the name of the study that investigated the impact of left atrial appendage clo-sure during cardiac surgery on the occurrence of early postoperative atrial fibrillation, stroke, and mortality?

Output: Circulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the impact of left atrial appendage clo-sure during cardiac surgery on the occurrence of early postoperative atrial fibrillation, stroke, and mortality?. ### Response: Circulation.


Instruction: How many patients underwent cardiac surgery?

Output: 10 633

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients underwent cardiac surgery?. ### Response: 10 633.


Instruction: What was the propensity score-matched analysis of 10 633 patients?

Output: Impact of left atrial appendage clo-sure during cardiac surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the propensity score-matched analysis of 10 633 patients?. ### Response: Impact of left atrial appendage clo-sure during cardiac surgery.


Instruction: What is another option for patients with AR?

Output: Cardiac catheterization with LV

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another option for patients with AR?. ### Response: Cardiac catheterization with LV.


Instruction: What can be done with LV and aortic angiography?

Output: Cardiac catheterization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be done with LV and aortic angiography?. ### Response: Cardiac catheterization.


Instruction: Where are the studies that support the recommendations summarized?

Output: Online Data Supplement 14.COR LOE Recommendations1 B-NR1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are the studies that support the recommendations summarized?. ### Response: Online Data Supplement 14.COR LOE Recommendations1 B-NR1.


Instruction: What is recommended in asymptomatic patients with chronic AR?

Output: treatment of hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended in asymptomatic patients with chronic AR?. ### Response: treatment of hypertension.


Instruction: What is GDMT for reduced LVEF with ACE inhibitors, ARBs, and/or sacubitril/valsartan recommended for?

Output: In patients with severe AR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is GDMT for reduced LVEF with ACE inhibitors, ARBs, and/or sacubitril/valsartan recommended for?. ### Response: In patients with severe AR.


Instruction: What is not evidence that vasodilating drugs reduce se-verity of AR or alter the disease course in patients with AR?

Output: systemic hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not evidence that vasodilating drugs reduce se-verity of AR or alter the disease course in patients with AR?. ### Response: systemic hypertension.


Instruction: What is associated with a wide pulse pressure?

Output: Severe AR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with a wide pulse pressure?. ### Response: Severe AR.


Instruction: What does GDMT apply to?

Output: patients with chronic asymptomatic AR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does GDMT apply to?. ### Response: patients with chronic asymptomatic AR.


Instruction: What is higher in patients with severe AR even when systemic vascular resistance is normal?

Output: systolic blood pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is higher in patients with severe AR even when systemic vascular resistance is normal?. ### Response: systolic blood pressure.


Instruction: How does transaortic stroke volume increase with medications?

Output: lower heart rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does transaortic stroke volume increase with medications?. ### Response: lower heart rate.


Instruction: What may result in a paradoxical apparent increase in blood pressure?

Output: Transaortic stroke volume increases further with medications that lower heart rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may result in a paradoxical apparent increase in blood pressure?. ### Response: Transaortic stroke volume increases further with medications that lower heart rate.


Instruction: What do ACE inhibitors or ARBs do not affect?

Output: heart rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do ACE inhibitors or ARBs do not affect?. ### Response: heart rate.


Instruction: How can avasodilating drugs reduce systolic blood pressure without a substantial reduction in diastol blood pressure?

Output: do not affect heart rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can avasodilating drugs reduce systolic blood pressure without a substantial reduction in diastol blood pressure?. ### Response: do not affect heart rate.


Instruction: What is not a substitute for AVR in symptomatic patients who are candidates for surgery?

Output: medical therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not a substitute for AVR in symptomatic patients who are candidates for surgery?. ### Response: medical therapy.


Instruction: What is helpful for alleviating symptoms in patients at very high surgical risk?

Output: medical therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is helpful for alleviating symptoms in patients at very high surgical risk?. ### Response: medical therapy.


Instruction: Why is there a high surgical risk?

Output: concomitant comorbid medical conditions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is there a high surgical risk?. ### Response: concomitant comorbid medical conditions.


Instruction: When was this article accessed?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this article accessed?. ### Response: April 28, 2023.


Instruction: What is the VA/DoD Clinical Practice Guideline for the Diagnosis and Management of Hypertension in the Primary Care Setting?

Output: March 2020

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for the Diagnosis and Management of Hypertension in the Primary Care Setting?. ### Response: March 2020.


Instruction: What is the acronym for Hypertension in the Department of Defense?

Output: B. Hypertension in the Department of Defense and the Department of Veterans Affairs Populations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Hypertension in the Department of Defense?. ### Response: B. Hypertension in the Department of Defense and the Department of Veterans Affairs Populations.


Instruction: What are the acronyms for Veterans Affairs Populations?

Output: B. Hypertension in the Department of Defense and the Department of Veterans Affairs Populations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the acronyms for Veterans Affairs Populations?. ### Response: B. Hypertension in the Department of Defense and the Department of Veterans Affairs Populations.


Instruction: How many A. Methods are there?

Output: 9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many A. Methods are there?. ### Response: 9.


Instruction: What is the scope of the 2014 Clinical Practice Guideline Recommendations?

Output: 14 D. Scope

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the scope of the 2014 Clinical Practice Guideline Recommendations?. ### Response: 14 D. Scope.


Instruction: What is a summary of Patient Focus Group Methods and Findings?

Output: 12 B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a summary of Patient Focus Group Methods and Findings?. ### Response: 12 B.


Instruction: What is the scope of the Clinical Practice Guideline?

Output: 14 D. Scope

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the scope of the Clinical Practice Guideline?. ### Response: 14 D. Scope.


Instruction: What are the Highlighted Features of the clinical practice guideline? What is shared decision making?

Output: Patient -centered Care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Highlighted Features of the clinical practice guideline? What is shared decision making?. ### Response: Patient -centered Care.


Instruction: How many H. Co-occurring Conditions are there?

Output: 15

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many H. Co-occurring Conditions are there?. ### Response: 15.


Instruction: How many IV. Guideline Work Groups exist?

Output: 16

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many IV. Guideline Work Groups exist?. ### Response: 16.


Instruction: What is the name of the group that implements the guideline?

Output: Guideline Work Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that implements the guideline?. ### Response: Guideline Work Group.


Instruction: What are the GRADE guidelines?

Output: 15

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the GRADE guidelines?. ### Response: 15.


Instruction: What is the rating of the quality of evidence?

Output: inconsistency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the rating of the quality of evidence?. ### Response: inconsistency.


Instruction: What are GRADE evidence pro files and summary offindings tables?

Output: Introduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are GRADE evidence pro files and summary offindings tables?. ### Response: Introduction.


Instruction: What are GRADE evidence pro files and summary offindings tables called?

Output: GRADE guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are GRADE evidence pro files and summary offindings tables called?. ### Response: GRADE guidelines.


Instruction: What is the purpose of GRADE guidelines?

Output: Going from evidence to recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of GRADE guidelines?. ### Response: Going from evidence to recommendation.


Instruction: Who is the author of Goingfrom evidence to recommendations?

Output: Andrews JC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of Goingfrom evidence to recommendations?. ### Response: Andrews JC.


Instruction: What are the GRADEguidelines?

Output: clinical practice guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the GRADEguidelines?. ### Response: clinical practice guidelines.


Instruction: What are determinants of a recommendation’s direction and strength?

Output: Going from evidence to recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are determinants of a recommendation’s direction and strength?. ### Response: Going from evidence to recommendation.


Instruction: What is the 9th ed of the American College of Chest Physicians Evidence-Based ClinicalPractice Guidelines?

Output: rombotic Therapy and Prevention of Thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 9th ed of the American College of Chest Physicians Evidence-Based ClinicalPractice Guidelines?. ### Response: rombotic Therapy and Prevention of Thrombosis.


Instruction: What are the patient values and preferences indecision making for for antithrombotic therapy?

Output: Antithrombotic Therapy and Prevention of Thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the patient values and preferences indecision making for for antithrombotic therapy?. ### Response: Antithrombotic Therapy and Prevention of Thrombosis.


Instruction: What is used to reach decisions on clinical practice guidelines when consensus iselusive?

Output: GRADE grid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used to reach decisions on clinical practice guidelines when consensus iselusive?. ### Response: GRADE grid.


Instruction: What is a GRADE grid?

Output: toreach decisions on clinical practice guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a GRADE grid?. ### Response: toreach decisions on clinical practice guidelines.


Instruction: When was the BMJ 337:a744?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the BMJ 337:a744?. ### Response: 2008.


Instruction: What is elusive in clinical practice guidelines?

Output: consensus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is elusive in clinical practice guidelines?. ### Response: consensus.


Instruction: What is the difference between Dabigatran and Warfarin in the treatment of venous thromboembolism?

Output: Edoxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between Dabigatran and Warfarin in the treatment of venous thromboembolism?. ### Response: Edoxaban.


Instruction: What is rivaroxaban used for?

Output: symptomatic venous thromboembolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is rivaroxaban used for?. ### Response: symptomatic venous thromboembolism.


Instruction: What is the difference between Tinzaparin and Warfarin?

Output: Dabigatran

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between Tinzaparin and Warfarin?. ### Response: Dabigatran.


Instruction: What drug is used for the treatment of symptomatic venousthromboembolism?

Output: Oral rivaroxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug is used for the treatment of symptomatic venousthromboembolism?. ### Response: Oral rivaroxaban.


Instruction: What is the difference between apixaban and warfarin?

Output: Dabigatran

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between apixaban and warfarin?. ### Response: Dabigatran.


Instruction: What drug is used for the treatment of acute venous thromboembolism?

Output: Dabigatran

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug is used for the treatment of acute venous thromboembolism?. ### Response: Dabigatran.


Instruction: What is the name of the drug used to treat symptomatic pulmonary emboli?

Output: Oralrivaroxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used to treat symptomatic pulmonary emboli?. ### Response: Oralrivaroxaban.


Instruction: How many people were involved in the study of oral apixaban?

Output: 10.Guyatt GH, Oxman AD, Kunz R, et al. GRADE guidelines:7. Rating the quality of evidence —inconsistency. J Clin Epidemiol .2011;64(12):1294-1302 .11.Guyatt GH, Oxman AD, Kunz R, et al. GRADE guidelines:8. Rating the quality of evidence —indirectness. J Clin Epidemiol .2011;64(12):1303-1310 .12.Guyatt GH, Oxman AD, Sultan S, et al. GRADE guidelines: 9. Ratingup the quality of evidence. JC l i nE p i d e m i o l . 2011;64(12):1311-1316 .13.Guyatt G, Oxman AD, Akl EA, et al. GRADE guidelines:1. Introduction —GRADE evidence pro ﬁles and summary ofﬁndings tables. J Clin Epidemiol . 2011;64(4):383-394 .14

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were involved in the study of oral apixaban?. ### Response: 10.Guyatt GH, Oxman AD, Kunz R, et al. GRADE guidelines:7. Rating the quality of evidence —inconsistency. J Clin Epidemiol .2011;64(12):1294-1302 .11.Guyatt GH, Oxman AD, Kunz R, et al. GRADE guidelines:8. Rating the quality of evidence —indirectness. J Clin Epidemiol .2011;64(12):1303-1310 .12.Guyatt GH, Oxman AD, Sultan S, et al. GRADE guidelines: 9. Ratingup the quality of evidence. JC l i nE p i d e m i o l . 2011;64(12):1311-1316 .13.Guyatt G, Oxman AD, Akl EA, et al. GRADE guidelines:1. Introduction —GRADE evidence pro ﬁles and summary ofﬁndings tables. J Clin Epidemiol . 2011;64(4):383-394 .14.


Instruction: What is not indicated for preventing stroke in patients with migraine?

Output: Closure of PFO

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not indicated for preventing stroke in patients with migraine?. ### Response: Closure of PFO.


Instruction: What is a migraine headache with aura?

Output: Class IIb; Level of Evidence B).

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a migraine headache with aura?. ### Response: Class IIb; Level of Evidence B)..


Instruction: What is the class of migraine patients?

Output: Class III

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the class of migraine patients?. ### Response: Class III.


Instruction: What was the original definition of metabolic syndrome?

Output: the pres-ence of ≥3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the original definition of metabolic syndrome?. ### Response: the pres-ence of ≥3.


Instruction: What is the triglycerides of a woman?

Output: ≥150 mg/dL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the triglycerides of a woman?. ### Response: ≥150 mg/dL.


Instruction: When was the ahajournals.org downloaded?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the ahajournals.org downloaded?. ### Response: April 28, 2023.


Instruction: Who adapted the 2011 ACCF/AHA/SCAI PCI Guideline?

Output: Dehmer et al.352Levine et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who adapted the 2011 ACCF/AHA/SCAI PCI Guideline?. ### Response: Dehmer et al.352Levine et al.


Instruction: When did Dehmer et al. publish their version of the 2011 PCI guideline with permission?

Output: May 1, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Dehmer et al. publish their version of the 2011 PCI guideline with permission?. ### Response: May 1, 2023.


Instruction: What is the name of the guideline that was adapted with permission by Levine and al.?

Output: ACCF/AHA/SCAI PCI Guideline e597

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the guideline that was adapted with permission by Levine and al.?. ### Response: ACCF/AHA/SCAI PCI Guideline e597.


Instruction: What is candesartan used for in proteinuric renal disease?

Output: renoprotection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is candesartan used for in proteinuric renal disease?. ### Response: renoprotection.


Instruction: What is Shiigai T, Shichiri M. Late escape from the antiproteinuric effect of aceinhibitors?

Output: candesartan

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Shiigai T, Shichiri M. Late escape from the antiproteinuric effect of aceinhibitors?. ### Response: candesartan.


Instruction: What is angiotensin II type 2 receptor incardiovascular disease?

Output: proteinuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is angiotensin II type 2 receptor incardiovascular disease?. ### Response: proteinuria.


Instruction: What is a meta-analysis of the effect ofmonotherapy and combination therapy with inhibitors of the reninangiotensesin system on proteinuria in renal disease.

Output: Aldosterone antagonistsfor preventing the progression of chronic kidney disease: a systematicreview and meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a meta-analysis of the effect ofmonotherapy and combination therapy with inhibitors of the reninangiotensesin system on proteinuria in renal disease.. ### Response: Aldosterone antagonistsfor preventing the progression of chronic kidney disease: a systematicreview and meta-analysis.


Instruction: Ann Intern Med 2008;148: 30–48.424.

Output: Meta-analysis: effect ofmonotherapy and combination therapy with inhibitors of the reninangiotensin system on proteinuria in renal disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Ann Intern Med 2008;148: 30–48.424.. ### Response: Meta-analysis: effect ofmonotherapy and combination therapy with inhibitors of the reninangiotensin system on proteinuria in renal disease.


Instruction: What is the name of the journal that published a systematic review and meta-analysis of aldosterone antagonists for preventing the progression of chronic kidney disease?

Output: Clin J Am Soc Nephrol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that published a systematic review and meta-analysis of aldosterone antagonists for preventing the progression of chronic kidney disease?. ### Response: Clin J Am Soc Nephrol.


Instruction: What is Lambers Heerspink HJ?

Output: de Zeeuw

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Lambers Heerspink HJ?. ### Response: de Zeeuw.


Instruction: What year was Circulation 123: 1049–1051.426?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was Circulation 123: 1049–1051.426?. ### Response: 2011.


Instruction: What is the name of the trial in Type 2 Diabetes using Cardio-Renal Endpoints?

Output: RENAAL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the trial in Type 2 Diabetes using Cardio-Renal Endpoints?. ### Response: RENAAL.


Instruction: When was the J Renin Angiotensin Aldosterone Syst 13: 387–393.427?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Renin Angiotensin Aldosterone Syst 13: 387–393.427?. ### Response: 2012.


Instruction: What study was terminated in high-risk patients with diabetes and renalimpairment?

Output: ALTITUDE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What study was terminated in high-risk patients with diabetes and renalimpairment?. ### Response: ALTITUDE.


Instruction: What is a valid clinical ‘hard’ endpoint in clinical nephrology trials?

Output: doubling of serumcreatinine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a valid clinical ‘hard’ endpoint in clinical nephrology trials?. ### Response: doubling of serumcreatinine.


Instruction: What is ACE-inhibitor use and the long-term risk of renal failure in diabetes?

Output: Suissa S, Hutchinson T, Brophy JM et al.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ACE-inhibitor use and the long-term risk of renal failure in diabetes?. ### Response: Suissa S, Hutchinson T, Brophy JM et al..


Instruction: Kidney Int 2006; 69:913-919.430 What is the late onset azotemia from RAAS blockade in?

Output: CKD patients with normal renal arteries and no precipitating risk factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Kidney Int 2006; 69:913-919.430 What is the late onset azotemia from RAAS blockade in?. ### Response: CKD patients with normal renal arteries and no precipitating risk factors.


Instruction: What is blockade in CKD patients with normal renal arteries and no precipitating risk factors?

Output: Late onset azotemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is blockade in CKD patients with normal renal arteries and no precipitating risk factors?. ### Response: Late onset azotemia.


Instruction: When did Ren Fail 2008 issue 30:73–80.431?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Ren Fail 2008 issue 30:73–80.431?. ### Response: 2008.


Instruction: What is the name of the post hocanalysis of the RENAAL trial results?

Output: Continuum of renoprotectionwith losartan at all stages of type 2 diabetic nephropathy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the post hocanalysis of the RENAAL trial results?. ### Response: Continuum of renoprotectionwith losartan at all stages of type 2 diabetic nephropathy.


Instruction: What was the name of the study?

Output: RENAAL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the study?. ### Response: RENAAL.


Instruction: What did the results of the RENAAL trial show?

Output: Continuum of renoprotectionwith losartan at all stages of type 2 diabetic nephropathy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the results of the RENAAL trial show?. ### Response: Continuum of renoprotectionwith losartan at all stages of type 2 diabetic nephropathy.


Instruction: When was the J Am Soc Nephrol 15:3117–3125.432?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Soc Nephrol 15:3117–3125.432?. ### Response: 2004.


Instruction: Who did Li PK, Chow KM, Wong TY, et al. effect of an angiotensin-convertingenzyme inhibitor on renal function?

Output: patients receivingperitoneal dialysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who did Li PK, Chow KM, Wong TY, et al. effect of an angiotensin-convertingenzyme inhibitor on renal function?. ### Response: patients receivingperitoneal dialysis.


Instruction: What is a conundrum of increased burden of end-stage renal disease in Asians?

Output: The conundrum of increased burden ofend-stage renal disease in Asians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a conundrum of increased burden of end-stage renal disease in Asians?. ### Response: The conundrum of increased burden ofend-stage renal disease in Asians.


Instruction: What is the name of the journal that studies the geographic, ethnic, age-related, and temporal variation in the incidence of end stage renal disease?

Output: Kidney Int

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies the geographic, ethnic, age-related, and temporal variation in the incidence of end stage renal disease?. ### Response: Kidney Int.


Instruction: In what year was Kidney Int 68: 2310-2316.434 published?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was Kidney Int 68: 2310-2316.434 published?. ### Response: 2005.


Instruction: What was the incidence of end-stage renal disease in Europe, Canada and the Asia-Pacific region from 1998 to 2002?

Output: Geographic, ethnic, age-relatedand temporal variation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the incidence of end-stage renal disease in Europe, Canada and the Asia-Pacific region from 1998 to 2002?. ### Response: Geographic, ethnic, age-relatedand temporal variation.


Instruction: What was Nephrol DialTransplant 2006: 21: 2178–2183.435?

Output: end-stage renal disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was Nephrol DialTransplant 2006: 21: 2178–2183.435?. ### Response: end-stage renal disease.


Instruction: How many European, Canadian, and Asian-Pacific populations were affected by ESRD from 1998-2002?

Output: 18

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many European, Canadian, and Asian-Pacific populations were affected by ESRD from 1998-2002?. ### Response: 18.


Instruction: When was the last time the enigma of hypertensiveESRD was observed?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last time the enigma of hypertensiveESRD was observed?. ### Response: 2002.


Instruction: Asian-Pacific populations, 1998 to 2002.

Output: 18

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Asian-Pacific populations, 1998 to 2002.. ### Response: 18.


Instruction: Am J Kidney Dis 2006; 48:183– 191.

Output: Am J Kidney Dis 2006; 48:183– 191

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Am J Kidney Dis 2006; 48:183– 191.. ### Response: Am J Kidney Dis 2006; 48:183– 191.


Instruction: What is ERT?

Output: evidence review team

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ERT?. ### Response: evidence review team.


Instruction: What is RAS?

Output: renin– angiotensin system

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is RAS?. ### Response: renin– angiotensin system.


Instruction: What type of disease is kidney disease?

Output: diabetic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of disease is kidney disease?. ### Response: diabetic.


Instruction: What is the name of the journal that provides guidelines for guideline development?

Output: Kidney International Supplements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that provides guidelines for guideline development?. ### Response: Kidney International Supplements.


Instruction: What is the name of the study that evaluated the cost-effectiveness of the implantable cardioverter-defibrillator?

Output: Canadian Implantable Defibrillator Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated the cost-effectiveness of the implantable cardioverter-defibrillator?. ### Response: Canadian Implantable Defibrillator Study.


Instruction: What are the results of the Canadian Implantable Defibrilator Study?

Output: Cost-effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of the Canadian Implantable Defibrilator Study?. ### Response: Cost-effectiveness.


Instruction: How does the CIDS compare to antiarrhythmic drugs?

Output: Cost-effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does the CIDS compare to antiarrhythmic drugs?. ### Response: Cost-effectiveness.


Instruction: What is the name of the Economic Analysis Substudy on Antiarrhythmics Versus Implantable Defibrillators?

Output: AVID

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Economic Analysis Substudy on Antiarrhythmics Versus Implantable Defibrillators?. ### Response: AVID.


Instruction: What are the results of the AVID economic analysis substudy?

Output: cost-effectiveness and cost-utility

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of the AVID economic analysis substudy?. ### Response: cost-effectiveness and cost-utility.


Instruction: How is the cost-effectiveness of implantable cardioverter-defibrilators evaluated?

Output: A European analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the cost-effectiveness of implantable cardioverter-defibrilators evaluated?. ### Response: A European analysis.


Instruction: What is the acronym for Automatic Defibrillator Implantation Trial (MADIT)-II?

Output: Multicenter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Automatic Defibrillator Implantation Trial (MADIT)-II?. ### Response: Multicenter.


Instruction: When did the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) take place?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) take place?. ### Response: 2006.


Instruction: What was the name of the trial that evaluated the cost-effectiveness of defi-brillation therapy in chronic stable heart failure?

Output: Sudden Cardiac Death in Heart Failure Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the trial that evaluated the cost-effectiveness of defi-brillation therapy in chronic stable heart failure?. ### Response: Sudden Cardiac Death in Heart Failure Trial.


Instruction: What is the acronym for SCD-HeFT?

Output: Sudden Cardiac Death in Heart Failure Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for SCD-HeFT?. ### Response: Sudden Cardiac Death in Heart Failure Trial.


Instruction: When did Circulation. 2006 issue 114:135–42?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circulation. 2006 issue 114:135–42?. ### Response: 2006.


Instruction: What are the benefits of implantable cardioverter defibrillators for Medicare beneficiaries?

Output: Effectiveness and cost-effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the benefits of implantable cardioverter defibrillators for Medicare beneficiaries?. ### Response: Effectiveness and cost-effectiveness.


Instruction: What are the implications of the Multicenter Automatic Defibrillator Implantation Trial-II?

Output: Clinical and eco-nomic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the implications of the Multicenter Automatic Defibrillator Implantation Trial-II?. ### Response: Clinical and eco-nomic.


Instruction: When was the Ann Intern Med 142:593-600 published?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Ann Intern Med 142:593-600 published?. ### Response: 2005.


Instruction: What is a model of cost-effectiveness of implantable cardioverter defibrilator therapy?

Output: Markov

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a model of cost-effectiveness of implantable cardioverter defibrilator therapy?. ### Response: Markov.


Instruction: What is the cost-effectiveness of implantable cardioverter-defibrillators?

Output: Lifetime cost-effec-tiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cost-effectiveness of implantable cardioverter-defibrillators?. ### Response: Lifetime cost-effec-tiveness.


Instruction: In what year did Health Technol Assess publish its 10:iii–iv, ix–xi, 1–164?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did Health Technol Assess publish its 10:iii–iv, ix–xi, 1–164?. ### Response: 2006.


Instruction: What is the cost-effectiveness of primary prophylactic implantable defibrillator therapy in patients with ischaemic or non-ischaemic heart disease: A European analysis?

Output: Lifetime cost-effec-tiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cost-effectiveness of primary prophylactic implantable defibrillator therapy in patients with ischaemic or non-ischaemic heart disease: A European analysis?. ### Response: Lifetime cost-effec-tiveness.


Instruction: What does Med. 2005:353:1471-80?

Output: Cost effectiveness of implant-able cardioverter-defibrillators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Med. 2005:353:1471-80?. ### Response: Cost effectiveness of implant-able cardioverter-defibrillators.


Instruction: Who is Cowie MR, Marshall D, Drummond M, et al?

Output: Lifetime cost-effec-tiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Cowie MR, Marshall D, Drummond M, et al?. ### Response: Lifetime cost-effec-tiveness.


Instruction: What is the cost-effectiveness of implanted defibrillators in young people with inherited cardiac arrhythmias?

Output: Lifetime cost-effec-tiveness of prophylactic implantation of cardioverter defibril-lator in patients with reduced left ventricular systolic function: Results of Markov modelling in a European population. Europace. 2008;11:716–26. S16-14. Goldenberg I, Moss AJ, Maron BJ, et al. Cost-effectiveness of implanted defibrillators in young people with inherited cardiac arrhythmias. Ann Noninvasive Electrocardiol. 2005;10 suppl:67–83. S16-15

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cost-effectiveness of implanted defibrillators in young people with inherited cardiac arrhythmias?. ### Response: Lifetime cost-effec-tiveness of prophylactic implantation of cardioverter defibril-lator in patients with reduced left ventricular systolic function: Results of Markov modelling in a European population. Europace. 2008;11:716–26. S16-14. Goldenberg I, Moss AJ, Maron BJ, et al. Cost-effectiveness of implanted defibrillators in young people with inherited cardiac arrhythmias. Ann Noninvasive Electrocardiol. 2005;10 suppl:67–83. S16-15.


Instruction: What are the results of Markov modelling in a European population?

Output: Lifetime cost-effec-tiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of Markov modelling in a European population?. ### Response: Lifetime cost-effec-tiveness.


Instruction: What are implanted cardiac defibrillators used in young people with inherited cardiac arrhythmias?

Output: Cost-effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are implanted cardiac defibrillators used in young people with inherited cardiac arrhythmias?. ### Response: Cost-effectiveness.


Instruction: What is the name of the study published in 2005 that looked at the use of implants in young patients?

Output: Multicenter Automatic Defibrillator Implantation Trial-II

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study published in 2005 that looked at the use of implants in young patients?. ### Response: Multicenter Automatic Defibrillator Implantation Trial-II.


Instruction: How many patients were treated with implants after coronary-artery bypass graft surgery?

Output: 16-9

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with implants after coronary-artery bypass graft surgery?. ### Response: 16-9.


Output: N Engl J Med.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: 1997;337:1569-75.. ### Response: N Engl J Med..


Instruction: What is the name of the study that investigated the use of an oral contraceptive?

Output: Multicenter Automatic Defibrillator Implantation Trial-II

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the use of an oral contraceptive?. ### Response: Multicenter Automatic Defibrillator Implantation Trial-II.


Instruction: What is the name of the confidential inquiry into cardiac catheter complications?

Output: West R, Ellis G, Brooks N, et al. Complications of diagnostic cardiac catheterisation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the confidential inquiry into cardiac catheter complications?. ### Response: West R, Ellis G, Brooks N, et al. Complications of diagnostic cardiac catheterisation.


Instruction: How many patients underwent percutaneous coronary revascularization?

Output: 33

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients underwent percutaneous coronary revascularization?. ### Response: 33.


Instruction: What year did Ann Intern Med publish?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Ann Intern Med publish?. ### Response: 2003.


Instruction: What type of revascularization is recommended?

Output: percutaneous

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of revascularization is recommended?. ### Response: percutaneous.


Instruction: What is the name of the journal that describes regional variation in cardiac catheteriza-tion appropriateness and baseline risk after acute myocardial infarction?

Output: J Am Coll Cardiol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that describes regional variation in cardiac catheteriza-tion appropriateness and baseline risk after acute myocardial infarction?. ### Response: J Am Coll Cardiol.


Instruction: When was the J Am Coll Cardiol. 2008 published?

Output: 2008;51:716–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol. 2008 published?. ### Response: 2008;51:716–.


Instruction: What is the rate of finding obstructive coronary artery disease at elective, diagnostic coronary angiogram?

Output: Hospital variability

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the rate of finding obstructive coronary artery disease at elective, diagnostic coronary angiogram?. ### Response: Hospital variability.


Instruction: What is Patel MR, Peterson ED, Dai D, et al. Low diagnostic yield of elective angiography?

Output: 36

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Patel MR, Peterson ED, Dai D, et al. Low diagnostic yield of elective angiography?. ### Response: 36.


Instruction: How many:886-95 did N Engl J Med. 2010:362?

Output: 37

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many:886-95 did N Engl J Med. 2010:362?. ### Response: 37.


Instruction: What is the V A CART Program?

Output: Veterans Affairs Clinical Assessment Reporting and Tracking

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the V A CART Program?. ### Response: Veterans Affairs Clinical Assessment Reporting and Tracking.


Instruction: What are the normal coronary rates for elective angiography in the VA Healthcare System?

Output: 35. Douglas PS, Patel MR, Bailey SR, et al. Hospital variability in the rate of finding obstructive coronary artery disease at elective, diagnostic coronary angiography. J Am Coll Cardiol. 2011;58:801–9. 36. Patel MR, Peterson ED, Dai D, et al. Low diagnostic yield of elective coronary angiography. N Engl J Med. 2010;362:886–95 37. Bradley SM, Maddox TM, Stanislawski MA, et al. Normal coronary rates for elective angiography in the Veterans Affairs Healthcare System: insights from the V A CART Program

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the normal coronary rates for elective angiography in the VA Healthcare System?. ### Response: 35. Douglas PS, Patel MR, Bailey SR, et al. Hospital variability in the rate of finding obstructive coronary artery disease at elective, diagnostic coronary angiography. J Am Coll Cardiol. 2011;58:801–9. 36. Patel MR, Peterson ED, Dai D, et al. Low diagnostic yield of elective coronary angiography. N Engl J Med. 2010;362:886–95 37. Bradley SM, Maddox TM, Stanislawski MA, et al. Normal coronary rates for elective angiography in the Veterans Affairs Healthcare System: insights from the V A CART Program.


Instruction: What is the name of the double-blind, placebo-controlled study of EDTA treatment of intermit-tent claudication?

Output: Guldager B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the double-blind, placebo-controlled study of EDTA treatment of intermit-tent claudication?. ### Response: Guldager B.


Instruction: What type of therapy is used for inter -mittent?

Output: Chelation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is used for inter -mittent?. ### Response: Chelation.


Instruction: How many people were enrolled in the randomized trial of Chelation Therapy for Intermit-Tent Claudication in 1994?

Output: 39. van Rij AM, Solomon C, Packer SG, et al. Chelation therapy for inter -mittent claudication. A double-blind, randomized, controlled trial. Circulation. 1994;90:1194–9. 40

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were enrolled in the randomized trial of Chelation Therapy for Intermit-Tent Claudication in 1994?. ### Response: 39. van Rij AM, Solomon C, Packer SG, et al. Chelation therapy for inter -mittent claudication. A double-blind, randomized, controlled trial. Circulation. 1994;90:1194–9. 40.


Instruction: What is the name of the double-blind, randomized, controlled trial of mittent claudication?

Output: EDTA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the double-blind, randomized, controlled trial of mittent claudication?. ### Response: EDTA.


Instruction: What is EDTA chelation therapy used for?

Output: intermit-tent claudication

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is EDTA chelation therapy used for?. ### Response: intermit-tent claudication.