Instruction: What is a randomized and controlled pilotstudy?

Output: Aerobic exercise in obese diabeticpatients with chronic kidney disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a randomized and controlled pilotstudy?. ### Response: Aerobic exercise in obese diabeticpatients with chronic kidney disease.


Instruction: What is the effect of moderate aerobic exercise training on endothelial function and arterial stiffness in CKD stages 3-4?

Output: a randomized controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of moderate aerobic exercise training on endothelial function and arterial stiffness in CKD stages 3-4?. ### Response: a randomized controlled trial.


Instruction: What was the outcome of the randomized controlled trial of exercise training?

Output: Effect of moderate aerobic exercise training on endothelial functionand arterial stiffness in CKD stages 3-4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome of the randomized controlled trial of exercise training?. ### Response: Effect of moderate aerobic exercise training on endothelial functionand arterial stiffness in CKD stages 3-4.


Instruction: How did Heiwe S, Jacobson SH compare exercise training in adults withCKD: a systematic review and meta-analysis?

Output: Am J Kidney Dis . 2015;66:285 –296.83. Heiwe S, Jacobson SH. Exercise training in adults with CKD: a systematicreview

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Heiwe S, Jacobson SH compare exercise training in adults withCKD: a systematic review and meta-analysis?. ### Response: Am J Kidney Dis . 2015;66:285 –296.83. Heiwe S, Jacobson SH. Exercise training in adults with CKD: a systematicreview.


Instruction: What is the name of the journal that studies the relationship between light-intensity physical activities and mortality in patients with type 2 diabetes?

Output: Clin J Am Soc Nephrol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies the relationship between light-intensity physical activities and mortality in patients with type 2 diabetes?. ### Response: Clin J Am Soc Nephrol.


Instruction: What are the names of the journals that study the association between light intensity physical activity and mortality?

Output: Clin J Am Soc Nephrol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the journals that study the association between light intensity physical activity and mortality?. ### Response: Clin J Am Soc Nephrol.


Instruction: What does dietary salt intake and mortality inpatients with type 2 diabetes do?

Output: kidney disease in high-riskindividuals with type 2 diabetes mellitus. JAMA Intern Med . 2013;173:1682 –1692 .74. Smyth A, Dunkler D, Gao P, et al. The relationship between estimatedsodium and potassium excretion and subsequent renal outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does dietary salt intake and mortality inpatients with type 2 diabetes do?. ### Response: kidney disease in high-riskindividuals with type 2 diabetes mellitus. JAMA Intern Med . 2013;173:1682 –1692 .74. Smyth A, Dunkler D, Gao P, et al. The relationship between estimatedsodium and potassium excretion and subsequent renal outcomes.


Instruction: When did Diabetes Care issue 34:703-709.86?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Diabetes Care issue 34:703-709.86?. ### Response: 2011.


Instruction: What is the name of the community-level prospective epidemiological cohort study?

Output: Urinary sodium excretion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the community-level prospective epidemiological cohort study?. ### Response: Urinary sodium excretion.


Instruction: Who is the BiCARB study group?

Output: Lancet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the BiCARB study group?. ### Response: Lancet.


Instruction: What is the name of the study group that studied oral sodium?

Output: BiCARB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study group that studied oral sodium?. ### Response: BiCARB.


Instruction: What is a cost-effectiveness measure of oral sodium compared to a placebo?

Output: Dietary reference values

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a cost-effectiveness measure of oral sodium compared to a placebo?. ### Response: Dietary reference values.


Instruction: What was the date of publication of Circulation. 2018:138:e272–e391. DOI: 10.1161/CIR.0000000000000549?

Output: September 25, 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the date of publication of Circulation. 2018:138:e272–e391. DOI: 10.1161/CIR.0000000000000549?. ### Response: September 25, 2018.


Instruction: AHA Scientific Statements  acute coronary syndrome  what?

Output: ◼ ambulatory ECG monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: AHA Scientific Statements  acute coronary syndrome  what?. ### Response: ◼ ambulatory ECG monitoring.


Instruction: What is a common cause of heart failure?

Output: genetic arrhythmias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a common cause of heart failure?. ### Response: genetic arrhythmias.


Instruction: What is an example of an implantable cardioverter-defibrillator?

Output: imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of an implantable cardioverter-defibrillator?. ### Response: imaging.


Instruction: How is myocardial infarction diagnosed?

Output: MR imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is myocardial infarction diagnosed?. ### Response: MR imaging.


Instruction: What type of infarction can cause premature ventricular beats?

Output: myocardial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of infarction can cause premature ventricular beats?. ### Response: myocardial.


Instruction: What kind of pathology can cause ventricular tachycardia?

Output: sarcoidosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What kind of pathology can cause ventricular tachycardia?. ### Response: sarcoidosis.


Instruction: Who is a member of the writing committee?

Output: ana M. Al-Khatib

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a member of the writing committee?. ### Response: ana M. Al-Khatib.


Instruction: What is ventricular tachycardia?

Output: ventricular fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ventricular tachycardia?. ### Response: ventricular fibrillation.


Instruction: Who is the Chair of the Writing Committee?

Output: William G. Stevenson

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Chair of the Writing Committee?. ### Response: William G. Stevenson.


Instruction: What is the name of the person who is the Vice Chair?

Output: Michael J. Ackerman

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the person who is the Vice Chair?. ### Response: Michael J. Ackerman.


Instruction: Who is the MD, FACC, FAHA?

Output: Richard L. Page

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the MD, FACC, FAHA?. ### Response: Richard L. Page.


Instruction: What is the PhD, FHRS?

Output: Timm Dickfeld, MD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the PhD, FHRS?. ### Response: Timm Dickfeld, MD.


Instruction: Who is the author of the AHA/ACC/HRS Guideline for Management of Patients With Stroke?

Output: William G. Stevenson

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of the AHA/ACC/HRS Guideline for Management of Patients With Stroke?. ### Response: William G. Stevenson.


Instruction: What is the name of the person who was the editor of the guideline for management of patients with Strokes?

Output: William G. Stevenson

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the person who was the editor of the guideline for management of patients with Strokes?. ### Response: William G. Stevenson.


Instruction: What is the AHA/ACC/HRS GUIDELINE for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death?

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the AHA/ACC/HRS GUIDELINE for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death?. ### Response: 2017.


Instruction: Who is required to recuse themselves from voting on sections?

Output: Writing committee members

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is required to recuse themselves from voting on sections?. ### Response: Writing committee members.


Instruction: Who is required to recuse themselves from voting on sections to which their specific rela-tionships with industry may apply?

Output: Writing committee members

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is required to recuse themselves from voting on sections to which their specific rela-tionships with industry may apply?. ### Response: Writing committee members.


Instruction: What is the name of the Task Force on Performance Measures Liaison?

Output: §ACC/AHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Performance Measures Liaison?. ### Response: §ACC/AHA.


Instruction: Who requested that this document be cited?

Output: The American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who requested that this document be cited?. ### Response: The American Heart Association.


Instruction: What is the name of the Task Force Members?

Output: Sana M. Al-Khatib

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force Members?. ### Response: Sana M. Al-Khatib.


Instruction: What is the 2017 AHA/ACC/HRS guideline for?

Output: Management of Patients With Ventricular Arrhythmias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2017 AHA/ACC/HRS guideline for?. ### Response: Management of Patients With Ventricular Arrhythmias.


Instruction: What could result in a lar ge incr ease in r eferrals t o centr es?

Output: new r ecommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could result in a lar ge incr ease in r eferrals t o centr es?. ### Response: new r ecommendations.


Instruction: What is likely to be additional cost s incurr ed in transf erring people t o these centr es?

Output: ial harm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is likely to be additional cost s incurr ed in transf erring people t o these centr es?. ### Response: ial harm.


Instruction: What will ha ve implications f or the spok e site for arranging transfer ers?

Output: additional cost s incurr ed in transf erring people t o these centr es

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will ha ve implications f or the spok e site for arranging transfer ers?. ### Response: additional cost s incurr ed in transf erring people t o these centr es.


Instruction: What is the hub sit e, wher e mor e people will be r eceiv ed?

Output: fast image transf er, referral, eligibility assessment and r esponsiv e repatriation syst ems

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the hub sit e, wher e mor e people will be r eceiv ed?. ### Response: fast image transf er, referral, eligibility assessment and r esponsiv e repatriation syst ems.


Instruction: What arrangement s for spok e sites ar ound a t hrombect omy hub?

Output: netw orked

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What arrangement s for spok e sites ar ound a t hrombect omy hub?. ### Response: netw orked.


Instruction: What is a t hrombect omy 'hub' wit h fast image transf er, referral, eligibility assessment and r esponsiv e repatriation syst ems?

Output: Ther e ma y need t o be netw orked arrangement s for spok e sites

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a t hrombect omy 'hub' wit h fast image transf er, referral, eligibility assessment and r esponsiv e repatriation syst ems?. ### Response: Ther e ma y need t o be netw orked arrangement s for spok e sites.


Instruction: The positiv e implications f or ot her aspect s of str oke car e help what?

Output: t o addr ess t he balance in demand f or resour ces

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The positiv e implications f or ot her aspect s of str oke car e help what?. ### Response: t o addr ess t he balance in demand f or resour ces.


Instruction: What will be a decr ease in demand for decompr essiv e hemicraniect omies and inpatient rehabilitation?

Output: reduction in t he need f or long-t erm social car e

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will be a decr ease in demand for decompr essiv e hemicraniect omies and inpatient rehabilitation?. ### Response: reduction in t he need f or long-t erm social car e.


Instruction: What would be a reduction in t he need for long-t erm social car e?

Output: Ther e ma y

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would be a reduction in t he need for long-t erm social car e?. ### Response: Ther e ma y.


Instruction: Blood pr essur e control for pe ople wi th acu te intracerebral haemorr hage Recommendations 1.5.4 to 1.5.8 Why the c ommi ttee made the r ecomenda?

Output: positiv e implications f or ot her aspect s of str oke car e help t o addr ess t he balance in demand f or resour ces

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Blood pr essur e control for pe ople wi th acu te intracerebral haemorr hage Recommendations 1.5.4 to 1.5.8 Why the c ommi ttee made the r ecomenda?. ### Response: positiv e implications f or ot her aspect s of str oke car e help t o addr ess t he balance in demand f or resour ces.


Instruction: Why did the c ommi ttee make the r ecommenda tions For the gr oups co vered, moderat e-quality e vidence fr om a lar ge clinical trial?

Output: could initially result in a lar ge incr ease in r eferrals t o centr es that alr eady ha ve thrombect omy ser vices

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why did the c ommi ttee make the r ecommenda tions For the gr oups co vered, moderat e-quality e vidence fr om a lar ge clinical trial?. ### Response: could initially result in a lar ge incr ease in r eferrals t o centr es that alr eady ha ve thrombect omy ser vices.


Instruction: What is EQ-5D utility index?

Output: quality of lif

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is EQ-5D utility index?. ### Response: quality of lif.


Instruction: What is an EQ-5D utility index?

Output: quality of lif

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an EQ-5D utility index?. ### Response: quality of lif.


Instruction: What is a tar get syst olic blood pr essur e of 140 mmHg?

Output: quality of lif e (EQ-5D utility index

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a tar get syst olic blood pr essur e of 140 mmHg?. ### Response: quality of lif e (EQ-5D utility index.


Instruction: What did the committee ackno wledge t he uncer tainty of ver the evidence?

Output: additional pot ential harms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee ackno wledge t he uncer tainty of ver the evidence?. ### Response: additional pot ential harms.


Instruction: How long did people who pr esent after 6 hours or less have to wait?

Output: 1  hour

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did people who pr esent after 6 hours or less have to wait?. ### Response: 1  hour.


Instruction: Who should be tak en int o account when considering rapid blood pr essur e lowering?

Output: t hese f actors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should be tak en int o account when considering rapid blood pr essur e lowering?. ### Response: t hese f actors.


Instruction: How long does it take for people to lower their blood pressure?

Output: 6 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take for people to lower their blood pressure?. ### Response: 6 hours.


Instruction: What is a systolic blood pressure greater than 220 mmHg?

Output: blood pr essur

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a systolic blood pressure greater than 220 mmHg?. ### Response: blood pr essur.


Instruction: Why did the committee remove the aim of r eaching t he tar getwit hin 1 hour?

Output: only a minority (33 .4%) of par ticipant s in t he INTERA CT2 trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why did the committee remove the aim of r eaching t he tar getwit hin 1 hour?. ### Response: only a minority (33 .4%) of par ticipant s in t he INTERA CT2 trial.


Instruction: How much of the participants in the INTERA CT2 trial were in the minority?

Output: 33 .4%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the participants in the INTERA CT2 trial were in the minority?. ### Response: 33 .4%).


Instruction: How long did the INTERA CT2 trial last?

Output: 13 April 2022

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the INTERA CT2 trial last?. ### Response: 13 April 2022.


Instruction: How much systolic blood pressure did the participants in t he trial achieve?

Output: 140  mmHg or lower

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much systolic blood pressure did the participants in t he trial achieve?. ### Response: 140  mmHg or lower.


Instruction: What was the tar get of the participants?

Output: 140 mmHg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the tar get of the participants?. ### Response: 140 mmHg.


Instruction: What is the name of the book that describes the diagnosis and initial management of a stroke and transient ischaemic attack in o ver 16s?

Output: NG128

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the book that describes the diagnosis and initial management of a stroke and transient ischaemic attack in o ver 16s?. ### Response: NG128.


Instruction: How many mmHg is pr essur e by in t he first hour?

Output: 60

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mmHg is pr essur e by in t he first hour?. ### Response: 60.


Instruction: What is the last updat ed 13 April 2022?

Output: Page 36of 48

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the last updat ed 13 April 2022?. ### Response: Page 36of 48.


Instruction: What year did Heart J.16:1825-1832?

Output: 1995

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Heart J.16:1825-1832?. ### Response: 1995.


Instruction: What is the name of the group that investigated the use of secondary preven-tion medications after coronary artery disease?

Output: REACH Registry Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that investigated the use of secondary preven-tion medications after coronary artery disease?. ### Response: REACH Registry Investigators.


Instruction: What are secondary preven-tion medications used for after coronary artery bypass graft surgery?

Output: Outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are secondary preven-tion medications used for after coronary artery bypass graft surgery?. ### Response: Outcomes.


Instruction: Ann Thorac Surg. 2007;83:993–1001. doi: 10.1016/j.athoracsur.2006.10.046.

Output: Outcomes associated with the use of secondary preven-tion medications after coronary artery bypass graft surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Ann Thorac Surg. 2007;83:993–1001. doi: 10.1016/j.athoracsur.2006.10.046.. ### Response: Outcomes associated with the use of secondary preven-tion medications after coronary artery bypass graft surgery.


Instruction: Who is the REACH Registry Investigator?

Output: Bangalore S, Steg G, Deedwania P, Crowley K, Eagle KA, Goto S, Ohman EM, Cannon CP, Smith SC, Zeymer U, Hoffman EB, Messerli FH, Bhatt DL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the REACH Registry Investigator?. ### Response: Bangalore S, Steg G, Deedwania P, Crowley K, Eagle KA, Goto S, Ohman EM, Cannon CP, Smith SC, Zeymer U, Hoffman EB, Messerli FH, Bhatt DL.


Instruction: What does -Blocker use and clini-cal outcomes in stable outpatients with and without coronary artery dis-ease?

Output: Outcomes associated with the use of secondary preven-tion medications after coronary artery bypass graft surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does -Blocker use and clini-cal outcomes in stable outpatients with and without coronary artery dis-ease?. ### Response: Outcomes associated with the use of secondary preven-tion medications after coronary artery bypass graft surgery.


Instruction: What are clinical practice guidelines?

Output: Chest. 2012;141:e531S–575

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are clinical practice guidelines?. ### Response: Chest. 2012;141:e531S–575.


Instruction: What is the title of the 2012 issue of Chest?

Output: clinical practice guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of the 2012 issue of Chest?. ### Response: clinical practice guidelines.


Instruction: When was this publication first published?

Output: April 23, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this publication first published?. ### Response: April 23, 2023.


Instruction: What are measures at rest?

Output: Int J Cardiol. 2001;81:131–7. 11. Skalski J, Allison TG, Miller TD. The safety of cardiopulmonary exercise testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are measures at rest?. ### Response: Int J Cardiol. 2001;81:131–7. 11. Skalski J, Allison TG, Miller TD. The safety of cardiopulmonary exercise testing.


Instruction: What is the safety of cardiopulmonary exercise testing in a population with high-risk cardiovascular diseases?

Output: safety

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the safety of cardiopulmonary exercise testing in a population with high-risk cardiovascular diseases?. ### Response: safety.


Instruction: What is symptom-limited car -diopulmonary exercise testing in patients with aortic stenosis?

Output: Safety

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is symptom-limited car -diopulmonary exercise testing in patients with aortic stenosis?. ### Response: Safety.


Instruction: What is the name of the mendelian randomization study that compared systolic blood pressure and risk of valvular heart disease?

Output: JAMA Cardiol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the mendelian randomization study that compared systolic blood pressure and risk of valvular heart disease?. ### Response: JAMA Cardiol.


Instruction: How many people in the UK have aortic valve disease?

Output: 5.4 million

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people in the UK have aortic valve disease?. ### Response: 5.4 million.


Instruction: What is the name of the study that analyzed 5.4 million adults?

Output: Elevated blood pressure and risk of aortic valve disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that analyzed 5.4 million adults?. ### Response: Elevated blood pressure and risk of aortic valve disease.


Instruction: How many adults in the United Kingdom have arteries?

Output: 5.4 million

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many adults in the United Kingdom have arteries?. ### Response: 5.4 million.


Instruction: Who is the author?

Output: Chockalingam A, Venkatesan S, Subramaniam T, et al. Safety and efficacy of angiotensin-converting enzyme inhibitors in symptomatic severe aortic stenosis: Symptomatic Cardiac Obstruction-Pilot Study of Enalapril in Aor -tic Stenosis (SCOPE-AS). Am Heart J. 2004;147:E19. 11. Nadir MA, Wei L, Elder DHJ, et al. Impact of renin-angiotensin system blockade therapy on outcome in aortic stenosis. J Am Coll Cardiol. 2011;58:570–6. 12. Rieck ÅE, Cramariuc D, Boman K, et al. Hypertension in aortic stenosis: implications for left ventricular structure and cardiovascular events. Hyper -tension. 2012;60:90–7. 13. Briand M, D

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author?. ### Response: Chockalingam A, Venkatesan S, Subramaniam T, et al. Safety and efficacy of angiotensin-converting enzyme inhibitors in symptomatic severe aortic stenosis: Symptomatic Cardiac Obstruction-Pilot Study of Enalapril in Aor -tic Stenosis (SCOPE-AS). Am Heart J. 2004;147:E19. 11. Nadir MA, Wei L, Elder DHJ, et al. Impact of renin-angiotensin system blockade therapy on outcome in aortic stenosis. J Am Coll Cardiol. 2011;58:570–6. 12. Rieck ÅE, Cramariuc D, Boman K, et al. Hypertension in aortic stenosis: implications for left ventricular structure and cardiovascular events. Hyper -tension. 2012;60:90–7. 13. Briand M, D.


Instruction: What study assessed optimal blood pressure in patients with asymptomatic aortic valve stenosis?

Output: Simvastatin Ezetimibe in Aortic Stenosis study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What study assessed optimal blood pressure in patients with asymptomatic aortic valve stenosis?. ### Response: Simvastatin Ezetimibe in Aortic Stenosis study.


Instruction: What is the acronym for the Simvastatin Ezetimibe in Aortic Stenosis study?

Output: SEAS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the Simvastatin Ezetimibe in Aortic Stenosis study?. ### Response: SEAS.


Instruction: In what year did Circulation issue 134:455-6?

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did Circulation issue 134:455-6?. ### Response: 2016.


Instruction: What is stenosis?

Output: asymptomatic aortic valve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is stenosis?. ### Response: asymptomatic aortic valve.


Instruction: What is the name of the randomized trial of inten-sive lipid-lowering therapy?

Output: Simvastatin Ezetimibe in Aortic Stenosis study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized trial of inten-sive lipid-lowering therapy?. ### Response: Simvastatin Ezetimibe in Aortic Stenosis study.


Instruction: How does rosuvas-tatin affect progression of aortic disease?

Output: Effect of lipid lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does rosuvas-tatin affect progression of aortic disease?. ### Response: Effect of lipid lowering.


Instruction: What is rosuvas-tatin used for?

Output: Intensive lipid lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is rosuvas-tatin used for?. ### Response: Intensive lipid lowering.


Instruction: What is the name of the ASTRONOMER trial?

Output: Aortic Stenosis Pro-gression Observation: Measuring Effects Of Rosuvastatin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the ASTRONOMER trial?. ### Response: Aortic Stenosis Pro-gression Observation: Measuring Effects Of Rosuvastatin.


Instruction: When was the Aortic Stenosis Progression Observation: Measuring Effects Of Rosuvastatin conducted?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Aortic Stenosis Progression Observation: Measuring Effects Of Rosuvastatin conducted?. ### Response: 2010.


Instruction: What is the name of the procedure used to implant a transcatheter aortic valve?

Output: Renin-angiotensin system block-ade therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the procedure used to implant a transcatheter aortic valve?. ### Response: Renin-angiotensin system block-ade therapy.


Instruction: What are the results of a renin-angiotensin inhibitor treatment?

Output: mortality and heart failure readmission

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of a renin-angiotensin inhibitor treatment?. ### Response: mortality and heart failure readmission.


Instruction: What is ramipril?

Output: angiotensin-converting enzyme inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ramipril?. ### Response: angiotensin-converting enzyme inhibitor.


Instruction: What is the name of the angiotensin-converting enzyme inhibitor in patients with mild to moderate aortic stenosis and preserved left ventricular function?

Output: ramipril

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the angiotensin-converting enzyme inhibitor in patients with mild to moderate aortic stenosis and preserved left ventricular function?. ### Response: ramipril.


Instruction: In what year did J Investig Med publish a report on the safety and efficacy of angioensin conversion enzyme inhibitors?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did J Investig Med publish a report on the safety and efficacy of angioensin conversion enzyme inhibitors?. ### Response: 2004.


Instruction: What is SCOPE-AS?

Output: Symptomatic Cardiac Obstruction-Pilot Study of Enalapril in Aor -tic Stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is SCOPE-AS?. ### Response: Symptomatic Cardiac Obstruction-Pilot Study of Enalapril in Aor -tic Stenosis.


Instruction: What is the name of the symptomatic Cardiac Obstruction-Pilot Study of Enalapril in Aortic Stenosis?

Output: SCOPE-AS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the symptomatic Cardiac Obstruction-Pilot Study of Enalapril in Aortic Stenosis?. ### Response: SCOPE-AS.


Instruction: What is the effect of therapy on outcome in aortic stenosis?

Output: Intensive lipid lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of therapy on outcome in aortic stenosis?. ### Response: Intensive lipid lowering.


Instruction: What is Rieck E, Cramariuc D, Boman K, et al. Hypertension and left ventricular structure are implications for what?

Output: cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Rieck E, Cramariuc D, Boman K, et al. Hypertension and left ventricular structure are implications for what?. ### Response: cardiovascular events.


Instruction: Kadem L, et al. Reduced systemic arterial compliance impacts significantly on left ventricular afterload and function in what?

Output: aor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Kadem L, et al. Reduced systemic arterial compliance impacts significantly on left ventricular afterload and function in what?. ### Response: aor.


Instruction: What was the 2017 High Blood Pressure Clinical Practice Guideline e17 discussed?

Output: guideline recommendations were devel-oped

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 2017 High Blood Pressure Clinical Practice Guideline e17 discussed?. ### Response: guideline recommendations were devel-oped.


Instruction: What is the name of the systematic review report published in conjunction with this guideline?

Output: Systematic Review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review report published in conjunction with this guideline?. ### Response: Systematic Review.


Instruction: What is published in conjunction with Pressure in Adults?

Output: “Systematic Review for the 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is published in conjunction with Pressure in Adults?. ### Response: “Systematic Review for the 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline.


Instruction: What did no writing committee member report?

Output: a RWI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did no writing committee member report?. ### Response: a RWI.


Instruction: Who chaired committee discussions in which the SPRINT results were presented?

Output: Dr. Carey

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who chaired committee discussions in which the SPRINT results were presented?. ### Response: Dr. Carey.


Instruction: Who chaired committee discussions in which the SPRINT results were considered?

Output: Dr. Carey

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who chaired committee discussions in which the SPRINT results were considered?. ### Response: Dr. Carey.


Instruction: What was the organization of the writing committee comprised of?

Output: clinicians, cardiolo-gists, epidemiologists, internists, an endocrinologist, a geri-atrician, a nephrologist, a neurologist, a nurse, a pharmacist, a physician assistant, and 2 lay/patient representatives

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the organization of the writing committee comprised of?. ### Response: clinicians, cardiolo-gists, epidemiologists, internists, an endocrinologist, a geri-atrician, a nephrologist, a neurologist, a nurse, a pharmacist, a physician assistant, and 2 lay/patient representatives.


Instruction: Who was a lay/patient representative?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was a lay/patient representative?. ### Response: 2.


Instruction: How many lay/patient representatives were there?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many lay/patient representatives were there?. ### Response: 2.


Instruction: When was this article updated?

Output: August 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this article updated?. ### Response: August 2015.


Instruction: Where did this article come from?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where did this article come from?. ### Response: http://ahajournals.org.


Instruction: What is a key element of the thrombotic response to plaque disrup-tion?

Output: platelet inhibition

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a key element of the thrombotic response to plaque disrup-tion?. ### Response: platelet inhibition.


Instruction: What is recommended in patients with SIHD unless contraindicated?

Output: platelet inhibition

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended in patients with SIHD unless contraindicated?. ### Response: platelet inhibition.


Instruction: Aspirin produces irreversible blockade of what?

Output: prostaglandinendoperoxide formation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Aspirin produces irreversible blockade of what?. ### Response: prostaglandinendoperoxide formation.


Instruction: How much reduction in SIHD did aspirin use cause?

Output: 37%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much reduction in SIHD did aspirin use cause?. ### Response: 37%.


Instruction: What was the association of aspirin use with a 37% reduction in the risk of serious vascular events?

Output: lower risk of bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the association of aspirin use with a 37% reduction in the risk of serious vascular events?. ### Response: lower risk of bleeding.


Instruction: What was a 53% decrease inthe risk of requiring coronaryangioplasty?

Output: aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a 53% decrease inthe risk of requiring coronaryangioplasty?. ### Response: aspirin.


Instruction: Almost two thirds of the patients included in the meta-analysis were participants in what?

Output: SAPAT (SwedishAngina Pectoris Aspirin Trial),

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Almost two thirds of the patients included in the meta-analysis were participants in what?. ### Response: SAPAT (SwedishAngina Pectoris Aspirin Trial),.


Instruction: What was the name of the meta-analysis?

Output: SwedishAngina Pectoris Aspirin Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the meta-analysis?. ### Response: SwedishAngina Pectoris Aspirin Trial.


Instruction: How long did the median stay on aspirin?

Output: 9 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the median stay on aspirin?. ### Response: 9 months.


Instruction: What is the difference between a dose of 75 to 162mg daily and 325mg in secondary prevention?

Output: equally as effective

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between a dose of 75 to 162mg daily and 325mg in secondary prevention?. ### Response: equally as effective.


Instruction: What is effective as 325 mg in secondaryprevention and is associated with a lower risk of bleeding?

Output: Aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is effective as 325 mg in secondaryprevention and is associated with a lower risk of bleeding?. ### Response: Aspirin.


Instruction: What is a thienopyridine derivative of?

Output: Clopidogrel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a thienopyridine derivative of?. ### Response: Clopidogrel.


Instruction: What is clopidogrel a derivative of?

Output: thienopyridine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is clopidogrel a derivative of?. ### Response: thienopyridine.


Instruction: What inhibits plateletaggregation via selective and irreversible inhibition of theadenosine diphosphate P2Y12 receptor?

Output: Clopidogrel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What inhibits plateletaggregation via selective and irreversible inhibition of theadenosine diphosphate P2Y12 receptor?. ### Response: Clopidogrel.


Instruction: What is clopidogrel superior to in the secondary prevention of MI and death?

Output: aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is clopidogrel superior to in the secondary prevention of MI and death?. ### Response: aspirin.


Instruction: What was small in the study?

Output: themagnitude of difference

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was small in the study?. ### Response: themagnitude of difference.


Instruction: Why remains an acceptable alternative agent in patients with SIHD?

Output: clopidogrel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why remains an acceptable alternative agent in patients with SIHD?. ### Response: clopidogrel.


Instruction: What is an acceptable alternative agent to aspirin?

Output: clopidogrel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an acceptable alternative agent to aspirin?. ### Response: clopidogrel.


Instruction: What has been shown to be beneficial in certain high-risk patients?

Output: combined treatment withaspirin and clopidogrel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been shown to be beneficial in certain high-risk patients?. ### Response: combined treatment withaspirin and clopidogrel.


Instruction: How was the CURE study conducted?

Output: randomized to clopidogrel plus aspirin (300 mg/d and 75mg/d) for an average of 9 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the CURE study conducted?. ### Response: randomized to clopidogrel plus aspirin (300 mg/d and 75mg/d) for an average of 9 months.


Instruction: How long were NSTEMI patients randomized to clopidogrel plus aspirin?

Output: 9 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long were NSTEMI patients randomized to clopidogrel plus aspirin?. ### Response: 9 months.


Instruction: What were the two doses of clopidogrel plus aspirine?

Output: 300 mg/d and 75mg/d

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the two doses of clopidogrel plus aspirine?. ### Response: 300 mg/d and 75mg/d.


Instruction: How long did the patients receive placebo plus apogelina?

Output: 15 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the patients receive placebo plus apogelina?. ### Response: 15 months.


Instruction: Which study found similar results?

Output: CREDO(Clopidogrel for Reduction of Events During Observation)study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which study found similar results?. ### Response: CREDO(Clopidogrel for Reduction of Events During Observation)study.


Instruction: What did the CREDO study show reduced the risk of?

Output: death, MI, or stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the CREDO study show reduced the risk of?. ### Response: death, MI, or stroke.


Instruction: How long did the combined therapy of aspirin and clopidogrel last?

Output: 1 year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the combined therapy of aspirin and clopidogrel last?. ### Response: 1 year.


Instruction: What is the name of the study that showed that combined therapy reduced the risks of death, MI, or stroke?

Output: CREDO

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that showed that combined therapy reduced the risks of death, MI, or stroke?. ### Response: CREDO.


Instruction: How many patients were treated with clopidogrel in the CHARISMA study?

Output: 15 603

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with clopidogrel in the CHARISMA study?. ### Response: 15 603.


Instruction: What type of stroke type did blacks and whites in California have?

Output: readmis-sion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of stroke type did blacks and whites in California have?. ### Response: readmis-sion.


Instruction: What is the name of the organization that investigates the reinitiation of stroke?

Output: Registry of the Canadian Stroke Network

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that investigates the reinitiation of stroke?. ### Response: Registry of the Canadian Stroke Network.


Instruction: What is the name of the BRAIN study?

Output: Best Practice for Reinitiating Anticoagulation Therapy After Intracranial Bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the BRAIN study?. ### Response: Best Practice for Reinitiating Anticoagulation Therapy After Intracranial Bleeding.


Instruction: When was this study published?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this study published?. ### Response: April 28, 2023.


Instruction: What is the name of the meta-analysis of randomized trials for ST-segment myocardial infarction?

Output: NORDISTEMI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis of randomized trials for ST-segment myocardial infarction?. ### Response: NORDISTEMI.


Instruction: What is another name for rescue angioplasty after failed fibrinolytic therapy?

Output: repeat fibrinolysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for rescue angioplasty after failed fibrinolytic therapy?. ### Response: repeat fibrinolysis.


Instruction: What is the name of the NORwegian study onstrict treatment of ST-elevation myocardial infarction?

Output: NORDISTEMI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the NORwegian study onstrict treatment of ST-elevation myocardial infarction?. ### Response: NORDISTEMI.


Instruction: When was the J Am Coll Cardiol 49:422–30.387 published?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol 49:422–30.387 published?. ### Response: 2007.


Instruction: When did the J Am CollCardiol issue 55:102–10.388?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the J Am CollCardiol issue 55:102–10.388?. ### Response: 2010.


Instruction: What was the outcome of the combined abciximab REteplase Stent Study?

Output: Immediate angioplasty versusstandard therapy with rescue angioplasty

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome of the combined abciximab REteplase Stent Study?. ### Response: Immediate angioplasty versusstandard therapy with rescue angioplasty.


Instruction: What is CARESS-in-AMI?

Output: an open, prospective, randomised, mul-ticentre trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CARESS-in-AMI?. ### Response: an open, prospective, randomised, mul-ticentre trial.


Instruction: What is the name of the randomised controlled trial?

Output: GRACIA-1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised controlled trial?. ### Response: GRACIA-1.


Instruction: How long after thrombolysis does Routine invasivestrategy take?

Output: 24 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after thrombolysis does Routine invasivestrategy take?. ### Response: 24 hours.


Instruction: What is a meta-analysis of early routine percutaneouscoronary intervention after fibrinolysis vs standard therapy inST-segment elevation myocardial infarction?

Output: randomized trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a meta-analysis of early routine percutaneouscoronary intervention after fibrinolysis vs standard therapy inST-segment elevation myocardial infarction?. ### Response: randomized trials.


Instruction: When did EurHeart J. 2010:31:2156–69.391.

Output: Early routine percutaneouscoronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did EurHeart J. 2010:31:2156–69.391.. ### Response: Early routine percutaneouscoronary intervention.


Instruction: When was Routine early angioplasty for acute mycardial infection?

Output: within 24 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Routine early angioplasty for acute mycardial infection?. ### Response: within 24 hours.


Instruction: What is the N Engl J Med?

Output: Routine early angioplastyafter fibrinolysis for acute myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the N Engl J Med?. ### Response: Routine early angioplastyafter fibrinolysis for acute myocardial infarction.


Instruction: What is the term for acute myocardial infarction?

Output: Rescue angioplastyafter failed thrombolytic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for acute myocardial infarction?. ### Response: Rescue angioplastyafter failed thrombolytic therapy.


Instruction: When did Bates ER write about reperfusion therapy?

Output: 1997

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Bates ER write about reperfusion therapy?. ### Response: 1997.


Instruction: What is a hub-and-spoke system of care called?

Output: systematic percutaneous coronary intervention after fibri-nolysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a hub-and-spoke system of care called?. ### Response: systematic percutaneous coronary intervention after fibri-nolysis.


Instruction: What is the name of the journal that studies the association between timeliness ofreperfusion therapy and clinical outcomes in ST-elevation myocardialinfarction?

Output: JAMA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies the association between timeliness ofreperfusion therapy and clinical outcomes in ST-elevation myocardialinfarction?. ### Response: JAMA.


Instruction: What are the names of the journals that study system delay and mortality among patients with STEMI treated with primary percutaneous coronaryintervention?

Output: Terkelsen CJ, Sorensen JT, Maeng M, et al. System delay and mortalityamong patients with STEMI treated with primary percutaneous coronaryintervention. JAMA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the journals that study system delay and mortality among patients with STEMI treated with primary percutaneous coronaryintervention?. ### Response: Terkelsen CJ, Sorensen JT, Maeng M, et al. System delay and mortalityamong patients with STEMI treated with primary percutaneous coronaryintervention. JAMA.


Instruction: What is the name of the program used to transfer ST-elevation myocardial infarction patients for percutaneous coronary revascularization?

Output: Stat Heart Program

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the program used to transfer ST-elevation myocardial infarction patients for percutaneous coronary revascularization?. ### Response: Stat Heart Program.


Instruction: How long can door-to-balloon times be achieved for patients transferred for ST-segment elevation?

Output: under 90 min

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long can door-to-balloon times be achieved for patients transferred for ST-segment elevation?. ### Response: under 90 min.


Instruction: What can be routinely achieved for patients transferred forST-segment elevation myocardial infarction percutaneous coronaryintervention in a rural setting?

Output: Door-to-balloon timesunder 90 min

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be routinely achieved for patients transferred forST-segment elevation myocardial infarction percutaneous coronaryintervention in a rural setting?. ### Response: Door-to-balloon timesunder 90 min.


Instruction: What is the J Am Coll Cardiol. 2011;57:272–9.398?

Output: A regional system

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the J Am Coll Cardiol. 2011;57:272–9.398?. ### Response: A regional system.


Instruction: What does recombinant PF4 provide?

Output: adequate heparin neutralization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does recombinant PF4 provide?. ### Response: adequate heparin neutralization.


Instruction: Preformed antibodies against what complex are important contributors to the pathophysiology of HIT?

Output: PF4-heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Preformed antibodies against what complex are important contributors to the pathophysiology of HIT?. ### Response: PF4-heparin.


Instruction: Patients previously exposed to heparin may have what?

Output: preformed antibodies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients previously exposed to heparin may have what?. ### Response: preformed antibodies.


Instruction: What risks an anamnestic response?

Output: the addition of exogenous PF4in the presence of heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What risks an anamnestic response?. ### Response: the addition of exogenous PF4in the presence of heparin.


Instruction: What is required to validate the safety of PF4 forheparin reversal after CPB?

Output: More clinicalexperience

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is required to validate the safety of PF4 forheparin reversal after CPB?. ### Response: More clinicalexperience.


Instruction: Reports document attempts at using other drugs for what?

Output: heparin neutralization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Reports document attempts at using other drugs for what?. ### Response: heparin neutralization.


Instruction: What drugs are tested for heparin neutralization?

Output: Methylene blue, hexadimethrine,vancomycin, and heparinase I

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drugs are tested for heparin neutralization?. ### Response: Methylene blue, hexadimethrine,vancomycin, and heparinase I.


Instruction: None of these drugs proved equivalent to what in its safety pro file?

Output: protamine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: None of these drugs proved equivalent to what in its safety pro file?. ### Response: protamine.


Instruction: What drug was compared with protamine in a multi-center, randomized, prospective trial?

Output: heparinase I

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug was compared with protamine in a multi-center, randomized, prospective trial?. ### Response: heparinase I.


Instruction: What was the result of heparinase I having an inferior safety pro file?

Output: increased transfusion andprolonged hospital stay

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the result of heparinase I having an inferior safety pro file?. ### Response: increased transfusion andprolonged hospital stay.


Instruction: What is considered the gold standard for reversal of hemeparin at this time?

Output: protamine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is considered the gold standard for reversal of hemeparin at this time?. ### Response: protamine.


Instruction: What is considered the gold standard for reversal of heparin anticoagulation?

Output: protamine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is considered the gold standard for reversal of heparin anticoagulation?. ### Response: protamine.


Instruction: If protaminecannot be used, there are not enough data to make what recommendation regarding safety and efficacy?

Output: arecommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: If protaminecannot be used, there are not enough data to make what recommendation regarding safety and efficacy?. ### Response: arecommendation.


Instruction: What is the ideal anticoagulation strategy for cardiac patients?

Output: Bivalirudin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ideal anticoagulation strategy for cardiac patients?. ### Response: Bivalirudin.


Instruction: What may be considered to improvehemostasis in extreme situations?

Output: a combination ofmodi ﬁed ultra ﬁltration, hemodialysis, and theadministration of recombinant factor VIIa with bloodproduct replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered to improvehemostasis in extreme situations?. ### Response: a combination ofmodi ﬁed ultra ﬁltration, hemodialysis, and theadministration of recombinant factor VIIa with bloodproduct replacement.


Instruction: What is the gold standard for anticoagulation therapy?

Output: Heparin and protamine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the gold standard for anticoagulation therapy?. ### Response: Heparin and protamine.


Instruction: What does a small subset of patients require for the conduct of CPB?

Output: heparin alternatives

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does a small subset of patients require for the conduct of CPB?. ### Response: heparin alternatives.


Instruction: Which drug seems to offer the safest heparin alternative?

Output: Bivalirudin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which drug seems to offer the safest heparin alternative?. ### Response: Bivalirudin.


Instruction: What is the safest heparin alternative?

Output: Bivalirudin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the safest heparin alternative?. ### Response: Bivalirudin.


Instruction: How long is the half-life of bivalirudin?

Output: 25 minutes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the half-life of bivalirudin?. ### Response: 25 minutes.


Instruction: What happens in bivalin-treated patients?

Output: coagulopathy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What happens in bivalin-treated patients?. ### Response: coagulopathy.


Instruction: There is no well-de finedreversal agent for what drug?

Output: bivalirudin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is no well-de finedreversal agent for what drug?. ### Response: bivalirudin.


Instruction: What type of in-terventions are required for hemorrhage control?

Output: unusual

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of in-terventions are required for hemorrhage control?. ### Response: unusual.


Instruction: What is available to address coagulopathy in cases of bivalirudin-related hemorahage?

Output: anecdotalexperience

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is available to address coagulopathy in cases of bivalirudin-related hemorahage?. ### Response: anecdotalexperience.


Instruction: A multifaceted approach offers the best chance of success for what type of patient?

Output: hemorrhage control for these pa-tients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A multifaceted approach offers the best chance of success for what type of patient?. ### Response: hemorrhage control for these pa-tients.


Instruction: What is an important part of hemorrhage control?

Output: Recombinant activated factor VII

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an important part of hemorrhage control?. ### Response: Recombinant activated factor VII.


Instruction: What are other in-terventions that are alsoadvocated?

Output: modi ﬁed ultra ﬁltration,hemodialysis, and clotting factor replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are other in-terventions that are alsoadvocated?. ### Response: modi ﬁed ultra ﬁltration,hemodialysis, and clotting factor replacement.


Instruction: What is the 2014 AHA/ACC NSTE-ACS Guideline e377Table 10?

Output: Plan of Care for Patients With NSTE-ACS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2014 AHA/ACC NSTE-ACS Guideline e377Table 10?. ### Response: Plan of Care for Patients With NSTE-ACS.


Instruction: What are the sections 6.2.1 and 6.2.2Beta blockers?

Output: Antithrombotic therapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the sections 6.2.1 and 6.2.2Beta blockers?. ### Response: Antithrombotic therapies.


Instruction: What is the 2013 Blood cholesterol CPG18?

Output: Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2013 Blood cholesterol CPG18?. ### Response: Hypertension.


Instruction: What is a 2014 SIHD focused update10?

Output: risk of bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a 2014 SIHD focused update10?. ### Response: risk of bleeding.


Instruction: How is AMI managed in STEMI patients?

Output: CPG19

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is AMI managed in STEMI patients?. ### Response: CPG19.


Instruction: What was the 2007 Science Advisory on the prevention of premature discontinuation of DAPT in patients with coronary artery stents504Inappropriate use of analgesics (NSAIDs)?

Output: CPG27

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 2007 Science Advisory on the prevention of premature discontinuation of DAPT in patients with coronary artery stents504Inappropriate use of analgesics (NSAIDs)?. ### Response: CPG27.


Instruction: What is the 2010 Expert consensus document on?

Output: PPIs and thienopyridines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2010 Expert consensus document on?. ### Response: PPIs and thienopyridines.


Instruction: What is MET capacity?

Output: Cardiorespiratory fitness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is MET capacity?. ### Response: Cardiorespiratory fitness.


Instruction: What is the scientific statement on sexual activity and cardiovascular disease?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the scientific statement on sexual activity and cardiovascular disease?. ### Response: 2012.


Instruction: What is the 2013 position statement on standards of medical care in diabetes?

Output: 507HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2013 position statement on standards of medical care in diabetes?. ### Response: 507HF.


Instruction: What was the 2011 Secondary prevention CPG27Statins?

Output: 2013 Hospital to Home Quality Initiative511

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 2011 Secondary prevention CPG27Statins?. ### Response: 2013 Hospital to Home Quality Initiative511.


Instruction: What was incorporated into the 2008 DBT CPG20?

Output: Focused update

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was incorporated into the 2008 DBT CPG20?. ### Response: Focused update.


Instruction: What is the 2013 Consensus document on sexual counseling for individuals with cardiovascular disease and their partners508Gender-Specific issues • 2007 Cardiovascular disease prevention in women CPG475Depression, stress, and anxiety • 2008 Science advisory on depression and coronary heart disease?

Output: Hospital to Home Quality Initiative

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2013 Consensus document on sexual counseling for individuals with cardiovascular disease and their partners508Gender-Specific issues • 2007 Cardiovascular disease prevention in women CPG475Depression, stress, and anxiety • 2008 Science advisory on depression and coronary heart disease?. ### Response: Hospital to Home Quality Initiative.


Instruction: What did the 2009 Consensus report on a comprehensive framework and preferred practices for measuring and reporting cultural competency do?

Output: Return to work schedule

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the 2009 Consensus report on a comprehensive framework and preferred practices for measuring and reporting cultural competency do?. ### Response: Return to work schedule.


Instruction: What was the primary care clinicianAdvanced practice nurse/physician assistant?

Output: Pharmacists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary care clinicianAdvanced practice nurse/physician assistant?. ### Response: Pharmacists.


Instruction: What is the name of the person who has discharge counseling for patients with HF or MI512?

Output: Primary care clinician

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the person who has discharge counseling for patients with HF or MI512?. ### Response: Primary care clinician.


Instruction: What are the names of the people who have discharge counseling?

Output: patients with HF or MI512

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the people who have discharge counseling?. ### Response: patients with HF or MI512.


Instruction: Where can you download the 2005 recommendations for prevention and control of influenza?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you download the 2005 recommendations for prevention and control of influenza?. ### Response: http://ahajournals.org.


Instruction: What is a risk factor for CVD and CKDprogression?

Output: KUrine albumin level of 30 to 300 mg per 24 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for CVD and CKDprogression?. ### Response: KUrine albumin level of 30 to 300 mg per 24 hours.


Instruction: What does KUrine albumin level of 30 to 300 mg per 24 hours mean?

Output: a risk factor for CVD and CKDprogression

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does KUrine albumin level of 30 to 300 mg per 24 hours mean?. ### Response: a risk factor for CVD and CKDprogression.


Instruction: What does BP r130/80 mm Hg suggest may reduce?

Output: progression of CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does BP r130/80 mm Hg suggest may reduce?. ### Response: progression of CKD.


Instruction: What is particularly important in CKD patients with high urine albumin levels?

Output: BP control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is particularly important in CKD patients with high urine albumin levels?. ### Response: BP control.


Instruction: What did short-term follow-up data from the MDRD study show?

Output: an interaction of BP target with level of urineprotein

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did short-term follow-up data from the MDRD study show?. ### Response: an interaction of BP target with level of urineprotein.


Instruction: How much urine did patients with 41 g of urine have?

Output: protein per 24 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much urine did patients with 41 g of urine have?. ### Response: protein per 24 hours.


Instruction: How much urine protein did patients have per 24 hours?

Output: 41 g

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much urine protein did patients have per 24 hours?. ### Response: 41 g.


Instruction: What was the GFRo f 2 5 – 5 5m /m i n p e r1. 7 3m2 in the MDRD Study A?

Output: lower protein levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the GFRo f 2 5 – 5 5m /m i n p e r1. 7 3m2 in the MDRD Study A?. ### Response: lower protein levels.


Instruction: Long-term follow-up showed a benefit of what?

Output: lower target BPs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Long-term follow-up showed a benefit of what?. ### Response: lower target BPs.


Instruction: What was the benefit of a low target BP and nointeraction with the urine pro tein level?

Output: reducing the risk of kidney outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the benefit of a low target BP and nointeraction with the urine pro tein level?. ### Response: reducing the risk of kidney outcomes.


Instruction: What was statistically significant in those with urine protein excretion of 40.3 g per 24 hours?

Output: the beneﬁt

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was statistically significant in those with urine protein excretion of 40.3 g per 24 hours?. ### Response: the beneﬁt.


Instruction: How much protein was excreted per 24 hours?

Output: 40.3 g

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much protein was excreted per 24 hours?. ### Response: 40.3 g.


Instruction: What may have been greater in those with higher urine protein levels?

Output: the risk r eduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may have been greater in those with higher urine protein levels?. ### Response: the risk r eduction.


Instruction: What did the MDRD study show in patients with p olycystic kidney disease and non-glomerular diseases that frequently have low urinealbumin levels?

Output: a beneﬁt withregard to kidney outcomes with a lower target BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the MDRD study show in patients with p olycystic kidney disease and non-glomerular diseases that frequently have low urinealbumin levels?. ### Response: a beneﬁt withregard to kidney outcomes with a lower target BP.


Instruction: What study showed a benefit with regard to kidney outcomes with a lower target BP?

Output: MDRD study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What study showed a benefit with regard to kidney outcomes with a lower target BP?. ### Response: MDRD study.


Instruction: What is a benefit of lower target BPs in patients withaP C R 4220 mg/g?

Output: 422 mg/mmol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a benefit of lower target BPs in patients withaP C R 4220 mg/g?. ### Response: 422 mg/mmol.


Instruction: What is unclear whether this cutoff can be translated into analbumin-level cutoff?

Output: PCR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is unclear whether this cutoff can be translated into analbumin-level cutoff?. ### Response: PCR.


Instruction: What is the ratio of glomerular albuminuria to tu bular proteinuria?

Output: analbumin-level cutoff

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ratio of glomerular albuminuria to tu bular proteinuria?. ### Response: analbumin-level cutoff.


Instruction: What was the effect of strict blood pressure control and ACE-Inhibitionon Progression of Chronic Renal Failure in PediatricPatients?

Output: reducing the risk of kidney outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the effect of strict blood pressure control and ACE-Inhibitionon Progression of Chronic Renal Failure in PediatricPatients?. ### Response: reducing the risk of kidney outcomes.


Instruction: In children with higher urine protein levels, what was the P140.06 for interaction of treatment targ et with urine protein level?

Output: risk r eduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In children with higher urine protein levels, what was the P140.06 for interaction of treatment targ et with urine protein level?. ### Response: risk r eduction.


Instruction: There have been no BP target trials involving what type of patient?

Output: CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There have been no BP target trials involving what type of patient?. ### Response: CKD.


Instruction: What did a lower diastolic BP target in CKD patients have?

Output: VD outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a lower diastolic BP target in CKD patients have?. ### Response: VD outcomes.


Instruction: What was the statistical power to detect a difference for those with a creatinine level 41.5 mg/dl[133mmol/l]?

Output: n ¼470

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the statistical power to detect a difference for those with a creatinine level 41.5 mg/dl[133mmol/l]?. ### Response: n ¼470.


Instruction: Why were albuminuria data not available?

Output: Because patients with CKD and microalbuminuriaare at high risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why were albuminuria data not available?. ### Response: Because patients with CKD and microalbuminuriaare at high risk.


Instruction: What is at high risk in non-diabetics and diabetics?

Output: patients with CKD and microalbuminuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is at high risk in non-diabetics and diabetics?. ### Response: patients with CKD and microalbuminuria.


Instruction: What does the Work Group suggest?

Output: 358 Kidney International Supplements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Work Group suggest?. ### Response: 358 Kidney International Supplements.


Instruction: What would be reasonable and prudent?

Output: patients and providers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would be reasonable and prudent?. ### Response: patients and providers.


Instruction: What would represent the conclusions of published studies and the collective wisdom of many experts on IE?

Output: fewer patients will be recommended for IE prophylaxis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would represent the conclusions of published studies and the collective wisdom of many experts on IE?. ### Response: fewer patients will be recommended for IE prophylaxis.


Instruction: What may substantive changes in IE prophylaxisguidelines violate long-standing expectations and prac-tice patterns by patients and healthcare providers?

Output: fewer patients will be recommended for IE prophylaxis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may substantive changes in IE prophylaxisguidelines violate long-standing expectations and prac-tice patterns by patients and healthcare providers?. ### Response: fewer patients will be recommended for IE prophylaxis.


Instruction: What does the Committee recognize?

Output: these new recommendations may causeconcern

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Committee recognize?. ### Response: these new recommendations may causeconcern.


Instruction: What are patients and healthcare providers' prac-tice patterns?

Output: long-standing expectations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients and healthcare providers' prac-tice patterns?. ### Response: long-standing expectations.


Instruction: Who recognizes that the new recommendations may causeconcern among patients who have previously received anti-biotic prophylaxis to prevent IE before dental or other procedures?

Output: The Com-mittee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who recognizes that the new recommendations may causeconcern among patients who have previously received anti-biotic prophylaxis to prevent IE before dental or other procedures?. ### Response: The Com-mittee.


Instruction: What are the main talking points that may be helpful for clinicians in reeducating their patients?

Output: Table 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the main talking points that may be helpful for clinicians in reeducating their patients?. ### Response: Table 2.


Instruction: What demands due diligence and critical analysis?

Output: To recommend such changes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What demands due diligence and critical analysis?. ### Response: To recommend such changes.


Instruction: For how long have healthcare providers assumed that antibioticsadministered in association with a drug would be effective?

Output: 50 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For how long have healthcare providers assumed that antibioticsadministered in association with a drug would be effective?. ### Response: 50 years.


Instruction: What did healthcare providers assume prevented IE in patients with underlying cardiac risk factors?

Output: antibiotics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did healthcare providers assume prevented IE in patients with underlying cardiac risk factors?. ### Response: antibiotics.


Instruction: Patients were educated about what?

Output: bacteremia-producing procedures and risk factors for IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients were educated about what?. ### Response: bacteremia-producing procedures and risk factors for IE.


Instruction: What were patients expected to receive?

Output: antibiotic prophylaxis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were patients expected to receive?. ### Response: antibiotic prophylaxis.


Instruction: What did patients with underlying cardiac conditions carry alifetime risk of?

Output: acquisition of IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did patients with underlying cardiac conditions carry alifetime risk of?. ### Response: acquisition of IE.


Instruction: What was effective and usually safe to prevent?

Output: ce-dure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was effective and usually safe to prevent?. ### Response: ce-dure.


Instruction: Who felt a sense of reassurance and comfort that antibiotics were administered in association with a dental proce-dure?

Output: Patients with underlying cardiac conditions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who felt a sense of reassurance and comfort that antibiotics were administered in association with a dental proce-dure?. ### Response: Patients with underlying cardiac conditions.


Instruction: Who felt a sense of obligation and legal responsibility to protect their patients from IE that might result from a procedure?

Output: Healthcareproviders, especially dentists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who felt a sense of obligation and legal responsibility to protect their patients from IE that might result from a procedure?. ### Response: Healthcareproviders, especially dentists.


Instruction: On the basis of recommendations in this revised document, substantially less patients will be recommended for what?

Output: IE prophylaxis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On the basis of recommendations in this revised document, substantially less patients will be recommended for what?. ### Response: IE prophylaxis.


Instruction: What is recommended for IE prophylaxis?

Output: fewer patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for IE prophylaxis?. ### Response: fewer patients.


Instruction: What have cases of IE temporally or remotely associated with an invasive procedure been the basis for?

Output: malpractice claims againsthealthcare providers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have cases of IE temporally or remotely associated with an invasive procedure been the basis for?. ### Response: malpractice claims againsthealthcare providers.


Instruction: What is the risk of stroke with hormonal contraception?

Output: 21.4 per 100 000 person-years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of stroke with hormonal contraception?. ### Response: 21.4 per 100 000 person-years.


Instruction: What is low in the age group of women who use contraception but high in women who don't?

Output: 21.4 per 100 000 person-years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is low in the age group of women who use contraception but high in women who don't?. ### Response: 21.4 per 100 000 person-years.


Instruction: What is the age group of women who use contraception?

Output: 15 to 49 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the age group of women who use contraception?. ### Response: 15 to 49 years.


Instruction: How much does the incidence of stroke in women using OC pills rise?

Output: 64.4 per 100 000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much does the incidence of stroke in women using OC pills rise?. ### Response: 64.4 per 100 000.


Instruction: What has been summarized in the cumulative risk of stroke?

Output: risk was increased for IS but not hemorrhagic strokes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been summarized in the cumulative risk of stroke?. ### Response: risk was increased for IS but not hemorrhagic strokes.


Instruction: How many different meta-analyses have been done on stroke in women using OC pills?

Output: 4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many different meta-analyses have been done on stroke in women using OC pills?. ### Response: 4.


Instruction: How many case-control and cohort studies did a meta-analysis of between 1960 and 1999 estimate a 2.75-fold increased odds of stroke?

Output: 16

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many case-control and cohort studies did a meta-analysis of between 1960 and 1999 estimate a 2.75-fold increased odds of stroke?. ### Response: 16.


Instruction: How many times increased odds of stroke are associated with any OC use?

Output: 2.75-fold

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many times increased odds of stroke are associated with any OC use?. ### Response: 2.75-fold.


Instruction: How many studies were published between 1970 and 2000?

Output: 20

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were published between 1970 and 2000?. ### Response: 20.


Instruction: What did a later meta-analysis of 20 studies find about the cohort studies?

Output: no increased risk of stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a later meta-analysis of 20 studies find about the cohort studies?. ### Response: no increased risk of stroke.


Instruction: How many of the 4 cohort studies reported strokes by subtype?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many of the 4 cohort studies reported strokes by subtype?. ### Response: 2.


Instruction: What was risk increased for IS but not hemorrhagic strokes?

Output: only 2 of the 4 cohort studies reported strokes by subtype

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was risk increased for IS but not hemorrhagic strokes?. ### Response: only 2 of the 4 cohort studies reported strokes by subtype.


Instruction: How many meta-analysis studies from 1980 to 2002 limited the risk of stroke?

Output: 285

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many meta-analysis studies from 1980 to 2002 limited the risk of stroke?. ### Response: 285.


Instruction: What did a meta-analysis of studies from 1980 to 2002 show about OC use?

Output: a comparable increased risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a meta-analysis of studies from 1980 to 2002 show about OC use?. ### Response: a comparable increased risk.


Instruction: What was the OR of OCs?

Output: 2.12

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the OR of OCs?. ### Response: 2.12.


Instruction: How many additional large cohort studies have been published since these meta-analyses?

Output: Two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many additional large cohort studies have been published since these meta-analyses?. ### Response: Two.


Instruction: How many Swedish women were included in the Women's Lifestyle and Health Cohort Study?

Output: 49 259

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many Swedish women were included in the Women's Lifestyle and Health Cohort Study?. ### Response: 49 259.