Instruction: What is an effective alternative to VKA anticoagulation?

Output: NOACs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an effective alternative to VKA anticoagulation?. ### Response: NOACs.


Instruction: What should be administered on the basis of the patient’s CHA2DS2-VASc score?

Output: a non–vitamin K oral anticoagulant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be administered on the basis of the patient’s CHA2DS2-VASc score?. ### Response: a non–vitamin K oral anticoagulant.


Instruction: For patients with AF and rheumatic MS, what is recommended?

Output: long-term VKA oral anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For patients with AF and rheumatic MS, what is recommended?. ### Response: long-term VKA oral anticoagulation.


Instruction: What is reasonable for patients with new-onset AF?

Output: anticoagulation with a VKA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable for patients with new-onset AF?. ### Response: anticoagulation with a VKA.


Instruction: What is not recommended in patients with mechanical heart valves with or without AF who require long-term anticoagulation with VKA to prevent valve thrombosis?

Output: NOACs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended in patients with mechanical heart valves with or without AF who require long-term anticoagulation with VKA to prevent valve thrombosis?. ### Response: NOACs.


Instruction: What is not recommended with VKA to prevent valve thrombosis?

Output: NOACs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended with VKA to prevent valve thrombosis?. ### Response: NOACs.


Instruction: What should patients with VHD and AF be evaluated for?

Output: risk of thromboembolic events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients with VHD and AF be evaluated for?. ### Response: risk of thromboembolic events.


Instruction: VKAs are the anticoagulation drugs of choice for patients with what?

Output: rheu-matic MS and mechanical heart valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: VKAs are the anticoagulation drugs of choice for patients with what?. ### Response: rheu-matic MS and mechanical heart valves.


Instruction: NOACs are an alternative to what in patients with AF?

Output: VKAs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: NOACs are an alternative to what in patients with AF?. ### Response: VKAs.


Instruction: What is the name of the alternative to VKAs?

Output: NOACs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the alternative to VKAs?. ### Response: NOACs.


Instruction: What is NICE 2018?

Output: Chronic Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE 2018?. ### Response: Chronic Heart Failure.


Instruction: What are the Outcomes No of Participants (studies) Follow up Quality of evidence?

Output: Relative effect  (95% CI)  Anticipated absolute effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Outcomes No of Participants (studies) Follow up Quality of evidence?. ### Response: Relative effect  (95% CI)  Anticipated absolute effects.


Instruction: What is the 95% CI on the risk with Usual care Risk difference with telemonitoring?

Output: months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 95% CI on the risk with Usual care Risk difference with telemonitoring?. ### Response: months.


Instruction: How many months inconsistency is there in the Quality of life component?

Output: 12

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many months inconsistency is there in the Quality of life component?. ### Response: 12.


Instruction: What percentage of the population is better indicated by a higher SF -36 Physical functioning component than the lower SF?

Output: 203

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the population is better indicated by a higher SF -36 Physical functioning component than the lower SF?. ### Response: 203.


Instruction: What was the mean QoL in the control groups?

Output: 38

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean QoL in the control groups?. ### Response: 38.


Instruction: What was higher in the intervention groups than the control group?

Output: mean QoL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was higher in the intervention groups than the control group?. ### Response: mean QoL.


Instruction: How many studies were conducted?

Output: 203 (1 study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were conducted?. ### Response: 203 (1 study.


Instruction: Why was there a risk of bias?

Output: imprecision

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was there a risk of bias?. ### Response: imprecision.


Instruction: How much higher was the mean QoL in the control groups?

Output: 38

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much higher was the mean QoL in the control groups?. ### Response: 38.


Instruction: How many studies indicated that MLWHFQ was better indicated by lower 285?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies indicated that MLWHFQ was better indicated by lower 285?. ### Response: 2.


Instruction: Why was VERY LOW1,2 due to risk of bias, imprecision?

Output: The mean QoL in the control groups was  32.6  The QoL in the intervention groups was  5.98 lower  (11.37 to 0.58 lower)  Quality of life (SF -36 Mental component summary)  Better indicated by higher  203 (1 study)  12 months  ⊕⊝⊝⊝  VERY LOW1,2 due to risk of bias, imprecision   The mean  QoL in the control groups was  55

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was VERY LOW1,2 due to risk of bias, imprecision?. ### Response: The mean QoL in the control groups was  32.6  The QoL in the intervention groups was  5.98 lower  (11.37 to 0.58 lower)  Quality of life (SF -36 Mental component summary)  Better indicated by higher  203 (1 study)  12 months  ⊕⊝⊝⊝  VERY LOW1,2 due to risk of bias, imprecision   The mean  QoL in the control groups was  55.


Instruction: How much lower was the QoL in the intervention groups?

Output: 5.98

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much lower was the QoL in the intervention groups?. ### Response: 5.98.


Instruction: How much higher was the quality of life (SF -36 Mental component summary) indicated by higher 203 (1 study) 12 months  VERY LOW1,2 due to risk factors?

Output: higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much higher was the quality of life (SF -36 Mental component summary) indicated by higher 203 (1 study) 12 months  VERY LOW1,2 due to risk factors?. ### Response: higher.


Instruction: How long was the mean QoL in the control groups?

Output: 32.6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the mean QoL in the control groups?. ### Response: 32.6.


Instruction: What is the risk of bias, imprecision?

Output: VERY LOW1,2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of bias, imprecision?. ### Response: VERY LOW1,2.


Instruction: How long did it take for the intervention groups to achieve a VERY LOW1 level of quality of life?

Output: 6 to 12 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for the intervention groups to achieve a VERY LOW1 level of quality of life?. ### Response: 6 to 12 months.


Instruction: How much lower was the mean QoL in the control groups?

Output: 32.6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much lower was the mean QoL in the control groups?. ### Response: 32.6.


Instruction: What was the risk of bias in the study?

Output: LOW1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk of bias in the study?. ### Response: LOW1.


Instruction: How much higher was the quality of life (SF-36 Physical component summary)?

Output: higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much higher was the quality of life (SF-36 Physical component summary)?. ### Response: higher.


Instruction: What was the mean QoL in the intervention groups?

Output: 2.1 higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean QoL in the intervention groups?. ### Response: 2.1 higher.


Instruction: What was downgraded by 1 increment if the majority of the evidence was at high risk of bias?

Output: 1 Downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was downgraded by 1 increment if the majority of the evidence was at high risk of bias?. ### Response: 1 Downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments.


Instruction: What was downgraded by 2 increments if the majority of the evidence was at very high risk of bias?

Output: m ajority of the evid ence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was downgraded by 2 increments if the majority of the evidence was at very high risk of bias?. ### Response: m ajority of the evid ence.


Instruction: What did the confidence interval cross if it crossed one MID?

Output: both MIDs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the confidence interval cross if it crossed one MID?. ### Response: both MIDs.


Instruction: By what increments did it downgrade if a confidence interval crossed both MIDs?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: By what increments did it downgrade if a confidence interval crossed both MIDs?. ### Response: 2.


Instruction: What did the Cochrane authors construct?

Output: Funnel plots

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Cochrane authors construct?. ### Response: Funnel plots.


Instruction: What was the potentia of a strong publication bias in the studies included within the review?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the potentia of a strong publication bias in the studies included within the review?. ### Response: 3.


Instruction: What technique was used in large RCTswith clinical important outcomes?

Output: standardized of ﬁce measurement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What technique was used in large RCTswith clinical important outcomes?. ### Response: standardized of ﬁce measurement.


Instruction: What cannot be readily translated to values obtained using standardized of fice measurement?

Output: values obtainedusing other techniques

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What cannot be readily translated to values obtained using standardized of fice measurement?. ### Response: values obtainedusing other techniques.


Instruction: If BP is not measured using the standardized technique, what does not apply?

Output: SBPtarget goal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: If BP is not measured using the standardized technique, what does not apply?. ### Response: SBPtarget goal.


Instruction: What does not apply to the standardized technique?

Output: SBPtarget goal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not apply to the standardized technique?. ### Response: SBPtarget goal.


Instruction: What does the adoption of a lower SBP do?

Output: If BP isnot measured using the standardized technique, the SBPtarget goal does not apply

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the adoption of a lower SBP do?. ### Response: If BP isnot measured using the standardized technique, the SBPtarget goal does not apply.


Instruction: What is the class of LV dysfunction?

Output: Class IIa

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the class of LV dysfunction?. ### Response: Class IIa.


Instruction: What can be added to the basic regimen of  -blocker, ACE inhibitor, and thiazide?

Output: a long-acting dihydropyridine CCB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be added to the basic regimen of  -blocker, ACE inhibitor, and thiazide?. ### Response: a long-acting dihydropyridine CCB.


Instruction: What should be used with cau-tion in patients with symptomatic CAD and hypertension?

Output: The combination of a β -blocker and either of the nondihydropyridine CCBs (diltiazem or verapamil)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be used with cau-tion in patients with symptomatic CAD and hypertension?. ### Response: The combination of a β -blocker and either of the nondihydropyridine CCBs (diltiazem or verapamil).


Instruction: What is the increased risk of significant brady-arrhythmias and HF?

Output: symptomatic CAD and hyperten-sion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the increased risk of significant brady-arrhythmias and HF?. ### Response: symptomatic CAD and hyperten-sion.


Instruction: For patients with stable angina, the BP target is what?

Output: <140/90 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For patients with stable angina, the BP target is what?. ### Response: <140/90 mm Hg.


Instruction: What is the BP target for patients with stable angina?

Output: <140/90 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the BP target for patients with stable angina?. ### Response: <140/90 mm Hg.


Instruction: What is a lower target BP in some individuals with CAD?

Output: (<130/80 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a lower target BP in some individuals with CAD?. ### Response: (<130/80 mm Hg.


Instruction: What are some individuals with CAD risk equivalents?

Output: carotid artery disease, PAD, abdomi-nal aort

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some individuals with CAD risk equivalents?. ### Response: carotid artery disease, PAD, abdomi-nal aort.


Instruction: What is a class IIb; Level of Evidence B?

Output: CAD risk equivalents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a class IIb; Level of Evidence B?. ### Response: CAD risk equivalents.


Instruction: There are no special contraindications for the use of what drugs?

Output: antiplatelet or anticoagu-lant drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There are no special contraindications for the use of what drugs?. ### Response: antiplatelet or anticoagu-lant drugs.


Instruction: What should be lowered with-out delay in patients with uncontrolled severe hypertension who are taking antiplatelet or anticoagulant drugs?

Output: the BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be lowered with-out delay in patients with uncontrolled severe hypertension who are taking antiplatelet or anticoagulant drugs?. ### Response: the BP.


Instruction: What should reduce the risk of hemorrhagic stroke?

Output: the BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should reduce the risk of hemorrhagic stroke?. ### Response: the BP.


Instruction: What is a major risk factor for CVD?

Output: brady-arrhythmias and HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a major risk factor for CVD?. ### Response: brady-arrhythmias and HF.


Instruction: What is the impact of hyper -tension on ACS outcomes not well described?

Output: major risk factor for CVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact of hyper -tension on ACS outcomes not well described?. ### Response: major risk factor for CVD.


Instruction: How many data are available on specific treatments for hypertension in patients with STEMI or non-ST-segment-elevation ACS?

Output: Few

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many data are available on specific treatments for hypertension in patients with STEMI or non-ST-segment-elevation ACS?. ### Response: Few.


Instruction: What is a non-ST-segment-elevation ACS?

Output: STEMI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a non-ST-segment-elevation ACS?. ### Response: STEMI.


Instruction: What is the ACTION Registry-Get With The Guidelines?

Output: Acute Coronary Treatment and Intervention Outcomes Network

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ACTION Registry-Get With The Guidelines?. ### Response: Acute Coronary Treatment and Intervention Outcomes Network.


Instruction: What is the prevalence of hypertension among ACS patients?

Output: double

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the prevalence of hypertension among ACS patients?. ### Response: double.


Instruction: What percentage of patients with STEMI have hypertension?

Output: 65.2%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients with STEMI have hypertension?. ### Response: 65.2%.


Instruction: How much do hypertension prevalence rates double among individuals >75 versus those 45?

Output: double

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much do hypertension prevalence rates double among individuals >75 versus those 45?. ### Response: double.


Instruction: What is the impact of hypertension on outcomes in ACS?

Output: com-plex

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact of hypertension on outcomes in ACS?. ### Response: com-plex.


Instruction: In patients with stabilized ACS, what was an independent predictor of death and MI at 90 days?

Output: hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with stabilized ACS, what was an independent predictor of death and MI at 90 days?. ### Response: hypertension.


Instruction: What is a predictor of death and MI at 90 days?

Output: hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a predictor of death and MI at 90 days?. ### Response: hypertension.


Instruction: Hypertension is integrated into the Thrombolysis in Myocardial Infarction risk score for UA/NSTEMI as one of several classic risk factors for CAD?

Output: 179

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hypertension is integrated into the Thrombolysis in Myocardial Infarction risk score for UA/NSTEMI as one of several classic risk factors for CAD?. ### Response: 179.


Instruction: What was independently associated with the composite end point of mortality and recurrent ischemic events?

Output: the variable of ≥ 3 risk factors for CAD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was independently associated with the composite end point of mortality and recurrent ischemic events?. ### Response: the variable of ≥ 3 risk factors for CAD.


Instruction: What does catheter ablation do for atrial fibrillation?

Output: use and cardioembolic risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does catheter ablation do for atrial fibrillation?. ### Response: use and cardioembolic risk.


Instruction: What does Eitel C, Koch J, Sommer P, et al. use of novel oral anticoagulants in a real-world cohort of patients undergo?

Output: catheter ablation of atrial fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Eitel C, Koch J, Sommer P, et al. use of novel oral anticoagulants in a real-world cohort of patients undergo?. ### Response: catheter ablation of atrial fibrillation.


Instruction: Euro-pace. 2013;15:1587–93.

Output: 22

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Euro-pace. 2013;15:1587–93.. ### Response: 22.


Instruction: What is the name of the study that investigated the impact of left atrial appendage clo-sure during cardiac surgery on the occurrence of early postoperative atrial fibrillation, stroke, and mortality?

Output: Circulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the impact of left atrial appendage clo-sure during cardiac surgery on the occurrence of early postoperative atrial fibrillation, stroke, and mortality?. ### Response: Circulation.


Instruction: How many patients underwent cardiac surgery?

Output: 10 633

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients underwent cardiac surgery?. ### Response: 10 633.


Instruction: What was the propensity score-matched analysis of 10 633 patients?

Output: Impact of left atrial appendage clo-sure during cardiac surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the propensity score-matched analysis of 10 633 patients?. ### Response: Impact of left atrial appendage clo-sure during cardiac surgery.


Instruction: What is the estimated glomerular fil-tration rate of 30 mL/min/1.73 m2) in the HOT trial?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the estimated glomerular fil-tration rate of 30 mL/min/1.73 m2) in the HOT trial?. ### Response: <.


Instruction: What do previous guideline statements endorse the use of aspirin for?

Output: cardiac

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do previous guideline statements endorse the use of aspirin for?. ### Response: cardiac.


Instruction: What do previous guideline statements endorse the use of for cardiac but not stroke prophylaxis among asymptomatic men?

Output: aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do previous guideline statements endorse the use of for cardiac but not stroke prophylaxis among asymptomatic men?. ### Response: aspirin.


Instruction: What is the risk sufficiently high for the benefits to outweigh the risks associated with treatment?

Output: diabetes mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk sufficiently high for the benefits to outweigh the risks associated with treatment?. ### Response: diabetes mellitus.


Instruction: What does cilostazol do in people with peripheral artery disease?

Output: prevention of a first stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does cilostazol do in people with peripheral artery disease?. ### Response: prevention of a first stroke.


Instruction: What does the lack of relevant trials do to the use of antiplatelet therapy?

Output: primary stroke prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the lack of relevant trials do to the use of antiplatelet therapy?. ### Response: primary stroke prevention.


Instruction: Aspirin and Antiplatelet Agents: Recommendations: What is reasonable for people whose risk is sufficiently high for the benefits to outweigh the risks associ-ated with treatment?

Output: The use of aspirin for cardiovascular (including but not specific to stroke) prophylaxis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Aspirin and Antiplatelet Agents: Recommendations: What is reasonable for people whose risk is sufficiently high for the benefits to outweigh the risks associ-ated with treatment?. ### Response: The use of aspirin for cardiovascular (including but not specific to stroke) prophylaxis.


Instruction: What is a cardiovascular risk calcula-tor to assist with?

Output: estimating 10-year risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a cardiovascular risk calcula-tor to assist with?. ### Response: estimating 10-year risk.


Instruction: What is a cardiovascular risk calcula-tor?

Output: to assist in estimating 10-year risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a cardiovascular risk calcula-tor?. ### Response: to assist in estimating 10-year risk.


Instruction: What can be found online at http://my.americanheart.org/?

Output: estimating 10-year risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be found online at http://my.americanheart.org/?. ### Response: estimating 10-year risk.


Instruction: Aspirin can be useful for the prevention of a first stroke among women?

Output: Aspirin (81 mg daily or 100 mg every other day

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Aspirin can be useful for the prevention of a first stroke among women?. ### Response: Aspirin (81 mg daily or 100 mg every other day.


Instruction: What is a class IIa; Level of Evidence B?

Output: Aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a class IIa; Level of Evidence B?. ### Response: Aspirin.


Instruction: What might be considered for the prevention of a first stroke in people with chronic kidney disease?

Output: Aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What might be considered for the prevention of a first stroke in people with chronic kidney disease?. ### Response: Aspirin.


Instruction: What type of kidney disease is recommended for prevention of a first stroke in people with chronic kidney disease?

Output: Aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of kidney disease is recommended for prevention of a first stroke in people with chronic kidney disease?. ### Response: Aspirin.


Instruction: What is the estimated glomerular filtration rate for people with kidney disease in class IIb; Level of Evidence C?

Output: <30 mL/min/1.73 m2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the estimated glomerular filtration rate for people with kidney disease in class IIb; Level of Evidence C?. ### Response: <30 mL/min/1.73 m2.


Instruction: What is Cilostazol reasonable for?

Output: prevention of a first stroke in people with peripheral arterial disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Cilostazol reasonable for?. ### Response: prevention of a first stroke in people with peripheral arterial disease.


Instruction: What is not useful for preventing a first stroke in low-risk individuals?

Output: Aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not useful for preventing a first stroke in low-risk individuals?. ### Response: Aspirin.


Instruction: What is not useful for preventing a first stroke in people with diabetes mellitus in the absence of other high-risk conditions?

Output: Aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not useful for preventing a first stroke in people with diabetes mellitus in the absence of other high-risk conditions?. ### Response: Aspirin.


Instruction: What is a first stroke in people with diabetes mellitus and asymptomatic peripheral artery disease defined as in the presence of an ankle brachial index 0.99 (Class III; Level of Evidence B)?

Output: asymptomatic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a first stroke in people with diabetes mellitus and asymptomatic peripheral artery disease defined as in the presence of an ankle brachial index 0.99 (Class III; Level of Evidence B)?. ### Response: asymptomatic.


Instruction: What is discussed in the relevant sections for other specific situations such as AF, carotid artery stenosis?

Output: The use of aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is discussed in the relevant sections for other specific situations such as AF, carotid artery stenosis?. ### Response: The use of aspirin.


Instruction: What type of AF is discussed in the relevant sections of this statement?

Output: Antiplatelet Agents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of AF is discussed in the relevant sections of this statement?. ### Response: Antiplatelet Agents.


Instruction: What is not recommended for the prevention of a first stroke (Class III; Level of Evidence C)?

Output: anti-platelet regimens

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended for the prevention of a first stroke (Class III; Level of Evidence C)?. ### Response: anti-platelet regimens.


Instruction: What class is Emergency Department Primary Prevention?

Output: Class III; Level of Evidence C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What class is Emergency Department Primary Prevention?. ### Response: Class III; Level of Evidence C.


Instruction: What is the Level of Evidence C?

Output: Class IIb

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Level of Evidence C?. ### Response: Class IIb.


Instruction: What were patients assigned to the lowerBP target randomized to receive?

Output: nisoldipine orenalapril

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were patients assigned to the lowerBP target randomized to receive?. ### Response: nisoldipine orenalapril.


Instruction: Why was this arm of the trial terminated early?

Output: higher incidence of myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was this arm of the trial terminated early?. ### Response: higher incidence of myocardial infarction.


Instruction: What was a pre-specified secondary end point?

Output: myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a pre-specified secondary end point?. ### Response: myocardial infarction.


Instruction: What is a pre-specified secondary end point in the nisoldipine group?

Output: myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a pre-specified secondary end point in the nisoldipine group?. ### Response: myocardial infarction.


Instruction: At 5 years of follow-up, there was no difference in what?

Output: the rate of pre-speciﬁed kidney outcomes or cardiovascular outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: At 5 years of follow-up, there was no difference in what?. ### Response: the rate of pre-speciﬁed kidney outcomes or cardiovascular outcomes.


Instruction: What group had a significantly lower incidence of death in the 75 mm Hg group?

Output: the group targeted to 80to 89 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What group had a significantly lower incidence of death in the 75 mm Hg group?. ### Response: the group targeted to 80to 89 mm Hg.


Instruction: What was the normotensive arm in the ABCD study comprised of?

Output: diabetic patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the normotensive arm in the ABCD study comprised of?. ### Response: diabetic patients.


Instruction: How many diabetes patients had CKD as defined?

Output: around 30%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many diabetes patients had CKD as defined?. ### Response: around 30%.


Instruction: What did mm Hg who were randomized to placebo or activetreatment reduce the diastolicBP to?

Output: 10 mm Hg below baseline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did mm Hg who were randomized to placebo or activetreatment reduce the diastolicBP to?. ### Response: 10 mm Hg below baseline.


Instruction: What was not associated with intensive treatment compared with less intensive treatment?

Output: changein creatinine clearance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not associated with intensive treatment compared with less intensive treatment?. ### Response: changein creatinine clearance.


Instruction: What was not associated with any difference in the change in creatinine clearance over the study period?

Output: intensive treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not associated with any difference in the change in creatinine clearance over the study period?. ### Response: intensive treatment.


Instruction: What was associated with a lower risk of progression from normo-albuminuria?

Output: intensive treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with a lower risk of progression from normo-albuminuria?. ### Response: intensive treatment.


Instruction: The inclusion criteria for the normotensive arm was what?

Output: prevents reliable extra-polation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The inclusion criteria for the normotensive arm was what?. ### Response: prevents reliable extra-polation.


Instruction: What prevents reliable extrapolation of this finding to patients whose baseline BP is4140/90 mm Hg?

Output: inclusion criteria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What prevents reliable extrapolation of this finding to patients whose baseline BP is4140/90 mm Hg?. ### Response: inclusion criteria.


Instruction: How many patients with diabetes and high cardiovascular risk were randomized to a systolic BP target?

Output: 4733

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with diabetes and high cardiovascular risk were randomized to a systolic BP target?. ### Response: 4733.


Instruction: What was the total of 39% in the ACCORD study?

Output: elevated urinary AER

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the total of 39% in the ACCORD study?. ### Response: elevated urinary AER.


Instruction: What percentage of patients had an elevated urinary AER?

Output: 39%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients had an elevated urinary AER?. ### Response: 39%.


Instruction: What was the primary composite endpoint?

Output: non-fatal myocardial infarction, non-fatal stroke, orcardiovascular death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary composite endpoint?. ### Response: non-fatal myocardial infarction, non-fatal stroke, orcardiovascular death.


Instruction: The lower systolic BPtarget was associated with a significant reduction in what?

Output: the riskof stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The lower systolic BPtarget was associated with a significant reduction in what?. ### Response: the riskof stroke.


Instruction: What was associated with a significant reduction in the risk of stroke?

Output: lower systolic BPtarget

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with a significant reduction in the risk of stroke?. ### Response: lower systolic BPtarget.


Instruction: How many events with o140 mm Hg target vs. 36 eventswith o120 mmHg target, P140.01)?

Output: 62

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many events with o140 mm Hg target vs. 36 eventswith o120 mmHg target, P140.01)?. ### Response: 62.


Instruction: What is the pre-specified second-ary end point?

Output: myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the pre-specified second-ary end point?. ### Response: myocardial infarction.


Instruction: How many events did the group targeted to o140 mm Hg have?

Output: 99

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many events did the group targeted to o140 mm Hg have?. ### Response: 99.


Instruction: What was the mean GFR in the intensive-therapy group at the last visit?

Output: o30 ml/min/1.73 m2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean GFR in the intensive-therapy group at the last visit?. ### Response: o30 ml/min/1.73 m2.


Instruction: In the intensive-therapy group at the last visit, how many instances of a single GFRmeasurement were there?

Output: more

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the intensive-therapy group at the last visit, how many instances of a single GFRmeasurement were there?. ### Response: more.


Instruction: What was the percentage of participants with more than one GFR reading o30 ml/min/1.73 m2?

Output: 38%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the percentage of participants with more than one GFR reading o30 ml/min/1.73 m2?. ### Response: 38%.


Instruction: What was the GFR reading in the two groups?

Output: 30 ml/min/1.73 m2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the GFR reading in the two groups?. ### Response: 30 ml/min/1.73 m2.


Instruction: What is the frequency of macroalbuminuria?

Output: overt proteinuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the frequency of macroalbuminuria?. ### Response: overt proteinuria.


Instruction: Who is the Chair of the 1ACC/AHA TASK FORCE ON PERFORMANCE MEASURESGregg C. Fonarow, MD, FACC, FAHA, Immediate Past Chair?

Output: Paul A. Heidenreich

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Chair of the 1ACC/AHA TASK FORCE ON PERFORMANCE MEASURESGregg C. Fonarow, MD, FACC, FAHA, Immediate Past Chair?. ### Response: Paul A. Heidenreich.


Instruction: What is the title of Nancy M. Albert, PhD?

Output: CCNS, CCRN, FAHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of Nancy M. Albert, PhD?. ### Response: CCNS, CCRN, FAHA.


Instruction: Who is the MD, MSc, FACC?

Output: Geoffrey D. Barnes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the MD, MSc, FACC?. ### Response: Geoffrey D. Barnes.


Instruction: What is the PhD?

Output: RN, ANP-BC, FAHA§; Sean O’Brien

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the PhD?. ### Response: RN, ANP-BC, FAHA§; Sean O’Brien.


Instruction: Which doctor is P. Michael Ho?

Output: MD, PhD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which doctor is P. Michael Ho?. ### Response: MD, PhD.


Instruction: What is available at http://circoutcomes.ahajournals.org?

Output: Circ Cardiovasc Qual Outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is available at http://circoutcomes.ahajournals.org?. ### Response: Circ Cardiovasc Qual Outcomes.


Instruction: Who is Tiffany Randolph?

Output: MD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Tiffany Randolph?. ### Response: MD.


Instruction: What is Andrea Russo's profession?

Output: MD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Andrea Russo's profession?. ### Response: MD.


Instruction: What is available at http://circoutcomes.ahajournals.org DOI: 10.1161/HCQ.0000000000000032*ACC/AHA Task Force on Performance Measures Liaison?

Output: Circ Cardiovasc Qual Outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is available at http://circoutcomes.ahajournals.org DOI: 10.1161/HCQ.0000000000000032*ACC/AHA Task Force on Performance Measures Liaison?. ### Response: Circ Cardiovasc Qual Outcomes.


Instruction: What are all members of the writing group required to complete and submit?

Output: a Disclosure Questionnaire

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are all members of the writing group required to complete and submit?. ### Response: a Disclosure Questionnaire.


Instruction: What are writing groups required to complete and submit?

Output: a Disclosure Questionnaire

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are writing groups required to complete and submit?. ### Response: a Disclosure Questionnaire.


Instruction: What does the Disclosure Questionnaire show?

Output: all such relationships that might be perceived as real or potential conflicts of interest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Disclosure Questionnaire show?. ### Response: all such relationships that might be perceived as real or potential conflicts of interest.


Instruction: When was this document approved?

Output: May 22, 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this document approved?. ### Response: May 22, 2017.


Instruction: Who approved this document?

Output: American College of Cardiology Clinical Policy Approval Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who approved this document?. ### Response: American College of Cardiology Clinical Policy Approval Committee.


Instruction: On what date did the American Heart Association Science Advisory and Coordinating Committee meet?

Output: June 7, 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On what date did the American Heart Association Science Advisory and Coordinating Committee meet?. ### Response: June 7, 2017.


Instruction: On what day did the Society for Cardiovascular Angiography and Interventions meet on July 17, 2017?

Output: August 11, 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On what day did the Society for Cardiovascular Angiography and Interventions meet on July 17, 2017?. ### Response: August 11, 2017.


Instruction: Where is the Comprehensive RWI Data Supplement table available?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the Comprehensive RWI Data Supplement table available?. ### Response: http://circoutcomes.ahajournals.org.


Instruction: What is available with this article at http://circoutcomes.ahajournals.org/lookup/suppl/doi:10.1161/HCQ.0000000000000032/-/DC1?

Output: The Comprehensive RWI Data Supplement table

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is available with this article at http://circoutcomes.ahajournals.org/lookup/suppl/doi:10.1161/HCQ.0000000000000032/-/DC1?. ### Response: The Comprehensive RWI Data Supplement table.


Instruction: Who requests that this document be cited?

Output: The American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who requests that this document be cited?. ### Response: The American Heart Association.


Instruction: What did the American College of Cardiology/American Heart Association Task Force on Performance Measures do in 2017?

Output: clinical performance and quality measures for adults with ST-elevation and non–ST-elevation myocardial infarction: a report

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the American College of Cardiology/American Heart Association Task Force on Performance Measures do in 2017?. ### Response: clinical performance and quality measures for adults with ST-elevation and non–ST-elevation myocardial infarction: a report.


Instruction: What was the name of the group that compiled the 2017 AHA/ACC clinical performance and quality measures for adults with ST-elevation myocardial infarction?

Output: American College of Cardiology/American Heart Association Task Force on Performance Measures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the group that compiled the 2017 AHA/ACC clinical performance and quality measures for adults with ST-elevation myocardial infarction?. ### Response: American College of Cardiology/American Heart Association Task Force on Performance Measures.


Instruction: What year did Qual Outcomes publish?

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Qual Outcomes publish?. ### Response: 2017.


Instruction: Where is this article published?

Output: Journal of the American College of Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is this article published?. ### Response: Journal of the American College of Cardiology.


Instruction: What is the name of the journal that published this article?

Output: Journal of the American College of Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that published this article?. ### Response: Journal of the American College of Cardiology.


Instruction: What was associated with improvements in the composite cardiovascular outcome?

Output: SBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with improvements in the composite cardiovascular outcome?. ### Response: SBP.


Instruction: What is likely benefit to further reductions of SBP for those patients with a baseline SBP between 130 and 150 mm Hg?

Output: improvements in the composite cardiovascular outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is likely benefit to further reductions of SBP for those patients with a baseline SBP between 130 and 150 mm Hg?. ### Response: improvements in the composite cardiovascular outcome.


Instruction: The SR by Ettehad et al. (2016) demonstrated benefit from a what?

Output: 10 mm Hg reduction in SBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The SR by Ettehad et al. (2016) demonstrated benefit from a what?. ### Response: 10 mm Hg reduction in SBP.


Instruction: What did al. (2016) demonstrate benefit from a 10 mm Hg reduction in SBP but did not evaluate?

Output: a specific target or threshold

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did al. (2016) demonstrate benefit from a 10 mm Hg reduction in SBP but did not evaluate?. ### Response: a specific target or threshold.


Instruction: Different SRs have come to different conclusions in recommending a specific target for what?

Output: SBP less than 150 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Different SRs have come to different conclusions in recommending a specific target for what?. ### Response: SBP less than 150 mm Hg.


Instruction: What is highly sensitive to inclusion criteria of studies in the SRs?

Output: SBP less than 150 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is highly sensitive to inclusion criteria of studies in the SRs?. ### Response: SBP less than 150 mm Hg.


Instruction: How many RCTs did Saiz et al. (2018) consider in hypertensive patients with a history of CVD?

Output: six

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs did Saiz et al. (2018) consider in hypertensive patients with a history of CVD?. ### Response: six.


Instruction: What type of disease is peripheral vascular occlusive disease?

Output: hypertensive

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of disease is peripheral vascular occlusive disease?. ### Response: hypertensive.


Instruction: What was the target blood pressure?

Output: 135/85 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the target blood pressure?. ### Response: 135/85 mm Hg.


Instruction: How did the therapy compare to standard therapy?

Output: no

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did the therapy compare to standard therapy?. ### Response: no.


Instruction: What is the name of the randomised trial that compares fresh frozen plasma and prothrombin complex concentrate in patients with intracranial haemorrhage related to vitamin K antagonists?

Output: Performance Measures for ICH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised trial that compares fresh frozen plasma and prothrombin complex concentrate in patients with intracranial haemorrhage related to vitamin K antagonists?. ### Response: Performance Measures for ICH.


Instruction: How many patients were treated with INCH?

Output: 29

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with INCH?. ### Response: 29.


Instruction: What is the name of the study that assessed stroke patients for rehabilita-tion during the acute hospitalization?

Output: Get With The Guidelines–Stroke program

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that assessed stroke patients for rehabilita-tion during the acute hospitalization?. ### Response: Get With The Guidelines–Stroke program.


Instruction: What program did Prvu Bettger JA, Kaltenbach L, Reeves MJ, Smith EE, Fonarow GC, Schwamm LH, Peterson ED use to assess stroke patients?

Output: Get With The Guidelines–Stroke program

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What program did Prvu Bettger JA, Kaltenbach L, Reeves MJ, Smith EE, Fonarow GC, Schwamm LH, Peterson ED use to assess stroke patients?. ### Response: Get With The Guidelines–Stroke program.


Instruction: What is the impact of hospital nursing characteristics on 30-day mortality?

Output: The impact of hospital nursing characteristics on 30-day mortality. Nurs Res. 2005;54:74–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact of hospital nursing characteristics on 30-day mortality?. ### Response: The impact of hospital nursing characteristics on 30-day mortality. Nurs Res. 2005;54:74–.


Instruction: How is admission to a neurologic/neurosurgical intensive care unit associated with reduced mortality rate after intrace-rebral hemorrhage?

Output: 30

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is admission to a neurologic/neurosurgical intensive care unit associated with reduced mortality rate after intrace-rebral hemorrhage?. ### Response: 30.


Instruction: How many patients did a cohort study of 105,043 patients in Riks-Stroke study?

Output: 32

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients did a cohort study of 105,043 patients in Riks-Stroke study?. ### Response: 32.


Instruction: How many patients were studied in Riks-Stroke?

Output: 105,043

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were studied in Riks-Stroke?. ### Response: 105,043.


Instruction: What was the name of the Swedish Stroke Register?

Output: Riks-Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the Swedish Stroke Register?. ### Response: Riks-Stroke.


Instruction: When was the J Neurol Neurosurg Psychiatry's 80th anniversary?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Neurol Neurosurg Psychiatry's 80th anniversary?. ### Response: 2009.


Instruction: What is a neurological emergency?

Output: Emergency neurological life support

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a neurological emergency?. ### Response: Emergency neurological life support.


Instruction: What is the name of the journal that deals with neurological emergencies?

Output: Neurocrit Care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that deals with neurological emergencies?. ### Response: Neurocrit Care.


Instruction: What is the 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults?

Output: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults?. ### Response: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.


Instruction: Who published the Heart Association Task Force on Clinical Practice Guidelines?

Output: American College of Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the Heart Association Task Force on Clinical Practice Guidelines?. ### Response: American College of Cardiology.


Instruction: What is the name of the group that published the guidelines?

Output: American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that published the guidelines?. ### Response: American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.


Instruction: When was the Hypertension Task Force published online?

Output: November 13, 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Hypertension Task Force published online?. ### Response: November 13, 2017.


Instruction: What is the name of the book published by NICE 2018?

Output: Chronic Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the book published by NICE 2018?. ### Response: Chronic Heart Failure.


Instruction: What does the committee consider the strength of each recommendation?

Output: appropriate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the committee consider the strength of each recommendation?. ### Response: appropriate.


Instruction: What are some of the recommendations that the committee believes the vast majority of healthcare professionals and patients would choose if they considered the evidence in the same way as the committee?

Output: a particular intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the recommendations that the committee believes the vast majority of healthcare professionals and patients would choose if they considered the evidence in the same way as the committee?. ### Response: a particular intervention.


Instruction: What is often the case if the benefits clearly outweigh the harms for most people and the intervention is likely to be cost effective?

Output: some patients would not choose an intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is often the case if the benefits clearly outweigh the harms for most people and the intervention is likely to be cost effective?. ### Response: some patients would not choose an intervention.


Instruction: What may happen if some patients are particularly averse to some side effect and others are not?

Output: some patients would not choose an intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may happen if some patients are particularly averse to some side effect and others are not?. ### Response: some patients would not choose an intervention.


Instruction: In these circumstances, the recommendation is generally weaker, although it may be what?

Output: possible to make stronger recommendations about specific groups of patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In these circumstances, the recommendation is generally weaker, although it may be what?. ### Response: possible to make stronger recommendations about specific groups of patients.


Instruction: What type of recommendation is generally weaker?

Output: er recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of recommendation is generally weaker?. ### Response: er recommendations.


Instruction: What is it possible to make stronger recommendations about specific groups of patients?

Output: it m ay

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is it possible to make stronger recommendations about specific groups of patients?. ### Response: it m ay.


Instruction: What do health professionals need to take?

Output: clinical judgement, knowledge and expertise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do health professionals need to take?. ### Response: clinical judgement, knowledge and expertise.


Instruction: What do readers need to know about a recommendation?

Output: The strength of the recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do readers need to know about a recommendation?. ### Response: The strength of the recommendation.


Instruction: The word ‘offer’ was used for what?

Output: strong recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The word ‘offer’ was used for what?. ### Response: strong recommendations.


Instruction: What is NICE's standard advice on recommendations about drugs, waiting times and ineffective interventions?

Output: Consistency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE's standard advice on recommendations about drugs, waiting times and ineffective interventions?. ### Response: Consistency.


Instruction: What are the main considerations specific to each recommendation?

Output: ‘Recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the main considerations specific to each recommendation?. ### Response: ‘Recommendations.


Instruction: Where are the main considerations specific to each recommendation outlined?

Output: ‘Recommendations and link to evidence’ sections within each chapter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are the main considerations specific to each recommendation outlined?. ### Response: ‘Recommendations and link to evidence’ sections within each chapter.


Instruction: What did the committee consider when areas were identified for which good evidence was lacking?

Output: making recommendation s for future research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee consider when areas were identified for which good evidence was lacking?. ### Response: making recommendation s for future research.


Instruction: What were the reasons for inclusion of a research recommendation?

Output:  the importance to patients or the population   national priorities   potential impact on the NHS and future NICE guidance   ethical and technical fea sibility

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the reasons for inclusion of a research recommendation?. ### Response:  the importance to patients or the population   national priorities   potential impact on the NHS and future NICE guidance   ethical and technical fea sibility.


Instruction: What was considered to be important to patients or the population?

Output: national priorities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was considered to be important to patients or the population?. ### Response: national priorities.


Instruction: How was the research recommendation considered?

Output: When areas were identified for which good evidence was lacking, the committee  considered making recommendation s for future research. Decisions about the inclusion of a research recommendation were based on factors such as:   the importance to patients or the population

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the research recommendation considered?. ### Response: When areas were identified for which good evidence was lacking, the committee  considered making recommendation s for future research. Decisions about the inclusion of a research recommendation were based on factors such as:   the importance to patients or the population.


Instruction: How long is NICE guidance subject to public consultation and feedback?

Output: 6 -week

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is NICE guidance subject to public consultation and feedback?. ### Response: 6 -week.


Instruction: What is part of the quality assurance and peer review of the document?

Output: Validation process

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is part of the quality assurance and peer review of the document?. ### Response: Validation process.


Instruction: What is posted on the NICE website?

Output: All comments received from registered stakeholders

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is posted on the NICE website?. ### Response: All comments received from registered stakeholders.


Instruction: What will NICE do after publication of the guideline?

Output: a review of whether the evidence base has progressed significantly to alter the guideline recommendations and warrant an u pdate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will NICE do after publication of the guideline?. ### Response: a review of whether the evidence base has progressed significantly to alter the guideline recommendations and warrant an u pdate.


Instruction: What has progressed significantly to alter the guideline recommendations and warrant an u pdate?

Output: the evidence base

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has progressed significantly to alter the guideline recommendations and warrant an u pdate?. ### Response: the evidence base.


Instruction: Healthcare providers need to use what when deciding?

Output: clinical judgement, knowledge and expertise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Healthcare providers need to use what when deciding?. ### Response: clinical judgement, knowledge and expertise.


Instruction: How much does tor therapy cost?

Output: 14 000/y

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much does tor therapy cost?. ### Response: 14 000/y.


Instruction: What is the bottom curve of the curve?

Output: relation-ship if the price were reduced by 75%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the bottom curve of the curve?. ### Response: relation-ship if the price were reduced by 75%.


Instruction: How much would the price be reduced if the therapy was reduced by 50%?

Output: $7 000/y

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much would the price be reduced if the therapy was reduced by 50%?. ### Response: $7 000/y.


Instruction: What indicates cardiovascular?

Output: S7.1-3 CV

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates cardiovascular?. ### Response: S7.1-3 CV.


Instruction: What indicates quality-adjusted life-years?

Output: QALY

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates quality-adjusted life-years?. ### Response: QALY.


Instruction: What has been shown to reduce the incidence of AMI,UA, and theneed for coronary revascularization in patients after MI withLV dysfunction?

Output: Clinical studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been shown to reduce the incidence of AMI,UA, and theneed for coronary revascularization in patients after MI withLV dysfunction?. ### Response: Clinical studies.


Instruction: What are the benefits of ACE inhibitors extended to patients with?

Output: IHD in the absence of LV dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the benefits of ACE inhibitors extended to patients with?. ### Response: IHD in the absence of LV dysfunction.


Instruction: What are the benefits of ACE inhibitors for patients with IHD in the absence of LV dysfunction?

Output: The benefits

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the benefits of ACE inhibitors for patients with IHD in the absence of LV dysfunction?. ### Response: The benefits.


Instruction: What is the full text of Stable Ischemic Heart Disease: Full Texte405Downloaded from http://ahajournals.org by on May 1, 2023?

Output: Fihn et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the full text of Stable Ischemic Heart Disease: Full Texte405Downloaded from http://ahajournals.org by on May 1, 2023?. ### Response: Fihn et al.


Instruction: What is the metabolic syndrome of nondiabetic individuals?

Output: assigned to chlorthalidone, amlodipine, or lisinopril as initial treatment for hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the metabolic syndrome of nondiabetic individuals?. ### Response: assigned to chlorthalidone, amlodipine, or lisinopril as initial treatment for hypertension.


Instruction: What is lisinopril an initial treatment for for?

Output: hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is lisinopril an initial treatment for for?. ### Response: hypertension.


Instruction: What is the effect ofcarvedilol on morbidity and mortality in patients withchronic heart failure?

Output: improvements in leftventricular function and survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect ofcarvedilol on morbidity and mortality in patients withchronic heart failure?. ### Response: improvements in leftventricular function and survival.


Instruction: What does Car-vedillol produce dose-related improvements in?

Output: leftventricular function and survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Car-vedillol produce dose-related improvements in?. ### Response: leftventricular function and survival.


Instruction: Who are MOCHA Investigators?

Output: Boehringer Ingelheim Pharmaceuticals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who are MOCHA Investigators?. ### Response: Boehringer Ingelheim Pharmaceuticals.


Instruction: What does Empagli flozin meet in Phase III heart failuretrial?

Output: primary endpoint

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Empagli flozin meet in Phase III heart failuretrial?. ### Response: primary endpoint.


Instruction: What is the primary endpoint of the Phase III trial?

Output: Empagli

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary endpoint of the Phase III trial?. ### Response: Empagli.


Instruction: What did Claggett BL, et al. do in patients with HFrEF treated withsacubitril/valsartan: the DAPA-HF Trial?

Output: Effect ofdapagli ﬂozin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Claggett BL, et al. do in patients with HFrEF treated withsacubitril/valsartan: the DAPA-HF Trial?. ### Response: Effect ofdapagli ﬂozin.


Instruction: What did Honigberg MC, Vardeny O, Vaduganathan M say about the use of sodium-glucoseco-transporter inhibitors in heart failure?

Output: Practical considerations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Honigberg MC, Vardeny O, Vaduganathan M say about the use of sodium-glucoseco-transporter inhibitors in heart failure?. ### Response: Practical considerations.


Instruction: What is hydralazine used for in blacks with heart failure?

Output: Combination

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hydralazine used for in blacks with heart failure?. ### Response: Combination.


Instruction: What is the N Engl J Med. 2004:351:2049–57.48.

Output: Combination ofisosorbide dinitrate and hydralazine in blacks withheart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the N Engl J Med. 2004:351:2049–57.48.. ### Response: Combination ofisosorbide dinitrate and hydralazine in blacks withheart failure.


Instruction: What is the DOSE-AHF trial?

Output: Diuretic Optimization Strategies Evaluation in AcuteHeart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the DOSE-AHF trial?. ### Response: Diuretic Optimization Strategies Evaluation in AcuteHeart Failure.


Instruction: What are the results of DOSE - AHF?

Output: In-ﬂuence of diuretic dose and route of administrationon loop diuretic ef ﬁciency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of DOSE - AHF?. ### Response: In-ﬂuence of diuretic dose and route of administrationon loop diuretic ef ﬁciency.


Instruction: When did Faera LE, MacLean TE, Fischer CM, et al. do?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Faera LE, MacLean TE, Fischer CM, et al. do?. ### Response: 2014.


Instruction: What is the name of the organization that provides virtual visits to patients with heart failure?

Output: Heart Failure Societyof America

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that provides virtual visits to patients with heart failure?. ### Response: Heart Failure Societyof America.


Instruction: What are the names of the organizations that provide virtual visits for care of heart failure patients?

Output: Heart Failure Societyof America

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the organizations that provide virtual visits for care of heart failure patients?. ### Response: Heart Failure Societyof America.


Instruction: What is a newly approved diagnosis for cardiacrehabilitation?

Output: Heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a newly approved diagnosis for cardiacrehabilitation?. ### Response: Heart failure.


Instruction: What is the J Am CollCardiol. 2015:65:2652–9.52.

Output: Heart failure as a newly approved diagnosis for cardiacrehabilitation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the J Am CollCardiol. 2015:65:2652–9.52.. ### Response: Heart failure as a newly approved diagnosis for cardiacrehabilitation.


Instruction: What are the considerations for during the COVID-19 pandemic?

Output: heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the considerations for during the COVID-19 pandemic?. ### Response: heart failure.


Instruction: What is the name of a mnemonic to aid referral in advanced heart failure?

Output: Baumwol J. “I Need Help

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of a mnemonic to aid referral in advanced heart failure?. ### Response: Baumwol J. “I Need Help.


Instruction: What is a term for "I Need Help"?

Output: —a mnemonic to aidtimely referral in advanced heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a term for "I Need Help"?. ### Response: —a mnemonic to aidtimely referral in advanced heart failure.


Instruction: When did the J Heart LungTransplant publish?

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the J Heart LungTransplant publish?. ### Response: 2017.


Instruction: What is the name of the pharmacological treatment for heart failure in pa-tients with recovered dilated cardiomyopathy?

Output: TRED-HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the pharmacological treatment for heart failure in pa-tients with recovered dilated cardiomyopathy?. ### Response: TRED-HF.


Instruction: When did the Lancet publish the results of the TRED-HF trial?

Output: 2019

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Lancet publish the results of the TRED-HF trial?. ### Response: 2019.


Instruction: Who is the JACC Scienti fic Expert Panel?

Output: Wilcox JE, Fang JC, Margulies KB, et al. Heartfailure with recovered left ventricular ejection fraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the JACC Scienti fic Expert Panel?. ### Response: Wilcox JE, Fang JC, Margulies KB, et al. Heartfailure with recovered left ventricular ejection fraction.


Instruction: What is JACC Scienti fic Expert Panel?

Output: Heartfailure with recovered left ventricular ejection fraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is JACC Scienti fic Expert Panel?. ### Response: Heartfailure with recovered left ventricular ejection fraction.


Instruction: What is the ventricular ejection fraction?

Output: left

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ventricular ejection fraction?. ### Response: left.


Instruction: What is D.J.'s specialty?

Output: anticoagulation and treatment of subsegmental PE. He has alsoauthored several papers related to long-term and extendedanticoagulation, treatment of subsegmental PE, and compressionstocking in preventing postthrombotic syndrome. D. J. ’s institutionhas received grant funding (no salary support) from Instituto de saludCarlos III, Sociedad Española de Neumología y Cirugía Torácica, andNeumoMadrid for studying PE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is D.J.'s specialty?. ### Response: anticoagulation and treatment of subsegmental PE. He has alsoauthored several papers related to long-term and extendedanticoagulation, treatment of subsegmental PE, and compressionstocking in preventing postthrombotic syndrome. D. J. ’s institutionhas received grant funding (no salary support) from Instituto de saludCarlos III, Sociedad Española de Neumología y Cirugía Torácica, andNeumoMadrid for studying PE.


Instruction: What is compressionstocking used for preventing?

Output: postthrombotic syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is compressionstocking used for preventing?. ### Response: postthrombotic syndrome.


Instruction: How much funding did D. J. receive?

Output: grant funding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much funding did D. J. receive?. ### Response: grant funding.


Instruction: What is the acronym for Pulmonary Embolism Thrombosis Study?

Output: PEITHO

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Pulmonary Embolism Thrombosis Study?. ### Response: PEITHO.


Instruction: Who was the principal investigator of an original study related to therole of the inferior vena cava filter?

Output: C. K.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the principal investigator of an original study related to therole of the inferior vena cava filter?. ### Response: C. K..


Instruction: What has C.K. been compensated for speaking engagements related to?

Output: VTE therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has C.K. been compensated for speaking engagements related to?. ### Response: VTE therapy.


Instruction: What has he participated in the derivation of scores for?

Output: identi ﬁcation of low-risk PE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has he participated in the derivation of scores for?. ### Response: identi ﬁcation of low-risk PE.


Instruction: Boehringer Ingelheim and BayerHealthcare related to what type of therapy?

Output: VTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Boehringer Ingelheim and BayerHealthcare related to what type of therapy?. ### Response: VTE.


Instruction: What is the name of the grant funded by the National Institutes of Health for catheter-assisted thrombus removal?

Output: C. K.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the grant funded by the National Institutes of Health for catheter-assisted thrombus removal?. ### Response: C. K..


Instruction: What do compression stockings prevent?

Output: postthrombotic syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do compression stockings prevent?. ### Response: postthrombotic syndrome.


Instruction: What has L. M. frequently lectured on?

Output: theduration of long-term anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has L. M. frequently lectured on?. ### Response: theduration of long-term anticoagulation.


Instruction: Who has received honoraria from for VTE talks?

Output: L. M. has frequently lectured on theduration of long-term anticoagulation and is a coauthor on severalrisk-strati ﬁcation papers. She has received honoraria from CHESTEnterprises for VTE talks. T. M. and C. S. K.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who has received honoraria from for VTE talks?. ### Response: L. M. has frequently lectured on theduration of long-term anticoagulation and is a coauthor on severalrisk-strati ﬁcation papers. She has received honoraria from CHESTEnterprises for VTE talks. T. M. and C. S. K..


Instruction: Who gave honoraria to C.S.K. for VTE Prep Courses?

Output: Chest Enterprises

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who gave honoraria to C.S.K. for VTE Prep Courses?. ### Response: Chest Enterprises.


Instruction: Who gave no salary support to T.M.'s institution for the Acute Medical Ill VTE Prevention WithExtended Duration Betrixaban Study?

Output: PortolaPharmaceuticals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who gave no salary support to T.M.'s institution for the Acute Medical Ill VTE Prevention WithExtended Duration Betrixaban Study?. ### Response: PortolaPharmaceuticals.


Instruction: What is the name of the drug that T. M. received support from?

Output: Bayer Pharmaceuticals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug that T. M. received support from?. ### Response: Bayer Pharmaceuticals.


Instruction: What company supported T.M.'s research project?

Output: Bayer Pharmaceuticals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What company supported T.M.'s research project?. ### Response: Bayer Pharmaceuticals.


Instruction: How many textbook chapters has T.m. authored?

Output: textbook chapters related tothrombolytic interventions in patients with acute PE and pulmonarythromboendarterectomy in chronic thromboembolic pulmonaryhypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many textbook chapters has T.m. authored?. ### Response: textbook chapters related tothrombolytic interventions in patients with acute PE and pulmonarythromboendarterectomy in chronic thromboembolic pulmonaryhypertension.


Instruction: What is thromboembolic pulmonaryhypertension?

Output: chronic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is thromboembolic pulmonaryhypertension?. ### Response: chronic.


Instruction: Who has funded S. M. S. and S. C. W.'s institution?

Output: Canadian Institutes of Health

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who has funded S. M. S. and S. C. W.'s institution?. ### Response: Canadian Institutes of Health.


Instruction: What is the D-dimer Optimal Duration Study Phase II?

Output: DODS-Extension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the D-dimer Optimal Duration Study Phase II?. ### Response: DODS-Extension.


Instruction: What was Bayer related to?

Output: VTE(EINSTEIN studies),

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was Bayer related to?. ### Response: VTE(EINSTEIN studies),.


Instruction: What was Bristol-Myers Squibb related to for the Secondary Prevention ofThromboembolism?

Output: apixaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was Bristol-Myers Squibb related to for the Secondary Prevention ofThromboembolism?. ### Response: apixaban.


Instruction: What does apixaban do for VTE?

Output: long-term treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does apixaban do for VTE?. ### Response: long-term treatment.


Instruction: What is the name of the company that funded the study?

Output: PortolaPharmaceuticals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the company that funded the study?. ### Response: PortolaPharmaceuticals.


Instruction: What is the difference in all-cause mortality between cancer and no cancer?

Output: RR 1.85

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference in all-cause mortality between cancer and no cancer?. ### Response: RR 1.85.


Instruction: What does low correspond to?

Output: patients without cancer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does low correspond to?. ### Response: patients without cancer.


Instruction: High corresponds to patients with what?

Output: metastatic cancer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: High corresponds to patients with what?. ### Response: metastatic cancer.


Instruction: What corresponds to patients with metastatic cancer?

Output: High

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What corresponds to patients with metastatic cancer?. ### Response: High.


Instruction: What registry was used to determine cont rol event rates?

Output: Computerized Registry of Patients with Venous Thromboembolism (RIETE) registry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What registry was used to determine cont rol event rates?. ### Response: Computerized Registry of Patients with Venous Thromboembolism (RIETE) registry.


Instruction: What is a subjective component of the diagnosis of recurrent VTE?

Output: there could be a lower threshold for diagnosis of recurrent VTE in VKA-treated patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a subjective component of the diagnosis of recurrent VTE?. ### Response: there could be a lower threshold for diagnosis of recurrent VTE in VKA-treated patients.


Instruction: What is widely practiced in VKA-treated patients?

Output: switching the treatment of such patients to LMWH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is widely practiced in VKA-treated patients?. ### Response: switching the treatment of such patients to LMWH.


Instruction: Why is there reluctance to switch to LMWH?

Output: there is no attractive alternative treatment option

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is there reluctance to switch to LMWH?. ### Response: there is no attractive alternative treatment option.


Instruction: What is the risk of recurrent VTE in patients who are already on LMWH?

Output: there is reluctance to diagnose recur rent VTE in patients whoare already on LMWH because there is no attractive alternative treatment option

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of recurrent VTE in patients who are already on LMWH?. ### Response: there is reluctance to diagnose recur rent VTE in patients whoare already on LMWH because there is no attractive alternative treatment option.


Instruction: What is low corresponds to patients without cancer?

Output: 3% estimate taken from recent large RCTs of acute treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is low corresponds to patients without cancer?. ### Response: 3% estimate taken from recent large RCTs of acute treatment.


Instruction: How does gCI compare to other cancer treatments?

Output: no effect and harm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does gCI compare to other cancer treatments?. ### Response: no effect and harm.