Instruction: Ongoing research on how to improve the entire process of initial decision-making and long-term follow-up is necessary?

Output: how a clinician can best interact with a patient

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Ongoing research on how to improve the entire process of initial decision-making and long-term follow-up is necessary?. ### Response: how a clinician can best interact with a patient.


Instruction: What is necessary to make a decision?

Output: taking multiple factors into consideration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is necessary to make a decision?. ### Response: taking multiple factors into consideration.


Instruction: What is used to predict the risk associated with CAC?

Output: the available data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used to predict the risk associated with CAC?. ### Response: the available data.


Instruction: How can data be amplified by new and ongoing studies to guide treatment decisions?

Output: Prognostic Significance of CAC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can data be amplified by new and ongoing studies to guide treatment decisions?. ### Response: Prognostic Significance of CAC.


Instruction: What is the predictive value of intermediate CAC scores?

Output: zero

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the predictive value of intermediate CAC scores?. ### Response: zero.


Instruction: What must be further verified in follow-up studies?

Output: the predictive significance of a CAC score of zero

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must be further verified in follow-up studies?. ### Response: the predictive significance of a CAC score of zero.


Instruction: How many subjects were included in theSHEP trial?

Output: 4736

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many subjects were included in theSHEP trial?. ### Response: 4736.


Instruction: What type of patients with reduced GFR can't be used to formulate a lower BP target in the context of CKD?

Output: excluded) patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of patients with reduced GFR can't be used to formulate a lower BP target in the context of CKD?. ### Response: excluded) patients.


Instruction: How many subjects were randomized to a placebo or BP reduction with or without atenolol?

Output: 4736

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many subjects were randomized to a placebo or BP reduction with or without atenolol?. ### Response: 4736.


Instruction: What was associated with a low diastolic BP on treatment?

Output: an increased risk of stroke, coronary heart disease and CVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with a low diastolic BP on treatment?. ### Response: an increased risk of stroke, coronary heart disease and CVD.


Instruction: What was associated with an increased risk of stroke, coronary heart disease and CVD?

Output: a low diastolic BP on treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with an increased risk of stroke, coronary heart disease and CVD?. ### Response: a low diastolic BP on treatment.


Instruction: What was a multi-national RCTcomparing verapamilsustained-release and atenolol-based treatment in 22,576 patients with hypertension and CAD?

Output: INVEST

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a multi-national RCTcomparing verapamilsustained-release and atenolol-based treatment in 22,576 patients with hypertension and CAD?. ### Response: INVEST.


Instruction: What was the primary outcome of the study?

Output: all-cause death, non-fatal myocardial infarction andnon-fatal stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary outcome of the study?. ### Response: all-cause death, non-fatal myocardial infarction andnon-fatal stroke.


Instruction: How did the risk of stroke increase with a BP lower than 119/84 mm Hg?

Output: progressively increased

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did the risk of stroke increase with a BP lower than 119/84 mm Hg?. ### Response: progressively increased.


Instruction: What did not increase with lower BP?

Output: stroke risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did not increase with lower BP?. ### Response: stroke risk.


Instruction: How many patients with peripheral artery disease had a J-shaped relationship?

Output: 2699

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with peripheral artery disease had a J-shaped relationship?. ### Response: 2699.


Instruction: What is the y s t o l i cB P of 135-145 mm Hg and a diastolicBP of 60-90 mm hg?

Output: primary outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the y s t o l i cB P of 135-145 mm Hg and a diastolicBP of 60-90 mm hg?. ### Response: primary outcome.


Instruction: The effect most strongly related to what?

Output: systolic BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The effect most strongly related to what?. ### Response: systolic BP.


Instruction: Stratifying patients into those aged o60, 60 too70, 70 to o80 andZ80 years produced a pronounced J-curve effect?

Output: 411

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Stratifying patients into those aged o60, 60 too70, 70 to o80 andZ80 years produced a pronounced J-curve effect?. ### Response: 411.


Instruction: What produced a pronounced J-curve effect when plotting survival versus diastolic BP?

Output: Stratifying patients into those aged o60, 60 too70, 70 to o80 andZ80 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What produced a pronounced J-curve effect when plotting survival versus diastolic BP?. ### Response: Stratifying patients into those aged o60, 60 too70, 70 to o80 andZ80 years.


Instruction: What was the HRnadir at 75 mm Hg up to 80 years?

Output: diastolic BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the HRnadir at 75 mm Hg up to 80 years?. ### Response: diastolic BP.


Instruction: How much increased withincreasing age?

Output: 115 mm Hg up to 70 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much increased withincreasing age?. ### Response: 115 mm Hg up to 70 years.


Instruction: How many patients with athero-sclerotic disease or diabetes with organ damage were enrolled in ONTARGET?

Output: 25,588

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with athero-sclerotic disease or diabetes with organ damage were enrolled in ONTARGET?. ### Response: 25,588.


Instruction: What was the nadir for on-treatment systolic BP?

Output: 130 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the nadir for on-treatment systolic BP?. ### Response: 130 mm Hg.


Instruction: What was observed except stroke in aretrospective analysis?

Output: all outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was observed except stroke in aretrospective analysis?. ### Response: all outcomes.


Instruction: What was associated with an increasedrisk of cardiovascular deaths and congestive heart failure in hypertensive type 2 diabetics?

Output: asystolic BP below 120 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with an increasedrisk of cardiovascular deaths and congestive heart failure in hypertensive type 2 diabetics?. ### Response: asystolic BP below 120 mm Hg.


Instruction: What did the ACCORD study show did not reducecardiovascular outcomes?

Output: targeting a systolicBP ofo120 mm Hg rather than o140 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the ACCORD study show did not reducecardiovascular outcomes?. ### Response: targeting a systolicBP ofo120 mm Hg rather than o140 mm Hg.


Instruction: What percentage of the lower BP group had serious adverse events compared to the higher BP target group?

Output: 3.3%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the lower BP group had serious adverse events compared to the higher BP target group?. ### Response: 3.3%.


Instruction: In CKD ND patients, there was a potential penalty paid for what?

Output: aggressive BP reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In CKD ND patients, there was a potential penalty paid for what?. ### Response: aggressive BP reduction.


Instruction: How many community-based longitudinal studies have been conducted in CKD ND patients?

Output: two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many community-based longitudinal studies have been conducted in CKD ND patients?. ### Response: two.


Instruction: What was observed in one study in which stroke and systolic BP were linked?

Output: a J-shaped

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was observed in one study in which stroke and systolic BP were linked?. ### Response: a J-shaped.


Instruction: What is the risk of systolic BP between 120 and129 mm Hg?

Output: loweststroke risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of systolic BP between 120 and129 mm Hg?. ### Response: loweststroke risk.


Instruction: What predicts progression of calcific aortic-valve disease?

Output: the Cardiovascular Health Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What predicts progression of calcific aortic-valve disease?. ### Response: the Cardiovascular Health Study.


Instruction: What is the name of the Multi-Ethnic Study of Atherosclerosis?

Output: MESA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Multi-Ethnic Study of Atherosclerosis?. ### Response: MESA.


Instruction: What is the name of the disease that affects the aortic valve in adults?

Output: calcific aortic-valve disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease that affects the aortic valve in adults?. ### Response: calcific aortic-valve disease.


Instruction: When did the JAMA issue its 300th issue?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the JAMA issue its 300th issue?. ### Response: 2008.


Instruction: How many patients were found to have a normal functioning or minimally dysfunctional bicuspid valve?

Output: 12

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were found to have a normal functioning or minimally dysfunctional bicuspid valve?. ### Response: 12.


Instruction: What is dysfunctional bicuspid aortic valve in the community?

Output: minimally

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is dysfunctional bicuspid aortic valve in the community?. ### Response: minimally.


Instruction: What is the current management of?

Output: calcific aortic stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the current management of?. ### Response: calcific aortic stenosis.


Instruction: How is valvular heart disease evaluated?

Output: by cardiac catheriza-tion and angiocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is valvular heart disease evaluated?. ### Response: by cardiac catheriza-tion and angiocardiography.


Instruction: What is the title of the 4th ed. of Valvular Heart Disease: A Companion to Braunwald’s Heart Disease?

Output: 2014:91–106

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of the 4th ed. of Valvular Heart Disease: A Companion to Braunwald’s Heart Disease?. ### Response: 2014:91–106.


Instruction: Where is Otto CM, Bonow RO, and Seifert S located?

Output: Philadelphia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Otto CM, Bonow RO, and Seifert S located?. ### Response: Philadelphia.


Instruction: What is hemodynamics in the cardiac catheterization laboratory of the 21st century?

Output: Nishimura RA, Carabello BA. Hemodynamics in the cardiac catheterization laboratory of the 21st century. Circulation. 2012;125:2138–50.3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hemodynamics in the cardiac catheterization laboratory of the 21st century?. ### Response: Nishimura RA, Carabello BA. Hemodynamics in the cardiac catheterization laboratory of the 21st century. Circulation. 2012;125:2138–50.3.


Instruction: What is exercise testing used for in patients with asymp-tomatic moderate or severe aortic stenosis?

Output: evaluate the indication for surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is exercise testing used for in patients with asymp-tomatic moderate or severe aortic stenosis?. ### Response: evaluate the indication for surgery.


Instruction: What does exercise testing help to stratify risk in?

Output: aortic stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does exercise testing help to stratify risk in?. ### Response: aortic stenosis.


Instruction: What is asymptomatic valvular aortic stenosis?

Output: surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is asymptomatic valvular aortic stenosis?. ### Response: surgery.


Instruction: What is the usefulness of exercise-stress echocardiography for?

Output: risk stratification of true asymptomatic patients with aortic valve stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the usefulness of exercise-stress echocardiography for?. ### Response: risk stratification of true asymptomatic patients with aortic valve stenosis.


Instruction: What is used for risk stratification of true asymptomatic patients with aortic valve stenosis?

Output: exercise-stress echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used for risk stratification of true asymptomatic patients with aortic valve stenosis?. ### Response: exercise-stress echocardiography.


Instruction: Exercise testing: a prospective study of what?

Output: complication rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Exercise testing: a prospective study of what?. ### Response: complication rates.


Instruction: What is the hemodynamic progression of aortic stenosis in adults assessed by?

Output: Doppler echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the hemodynamic progression of aortic stenosis in adults assessed by?. ### Response: Doppler echocardiography.


Instruction: What did Lancellotti P, Lebois F, Simon M, et al. Prognostic importance of quantitative exercise Doppler echocardiography in?

Output: asymptomatic valvular aortic stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Lancellotti P, Lebois F, Simon M, et al. Prognostic importance of quantitative exercise Doppler echocardiography in?. ### Response: asymptomatic valvular aortic stenosis.


Instruction: Circulation. 2005;112:I377-82.

Output: 8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation. 2005;112:I377-82.. ### Response: 8.


Instruction: What is exercise testing used for?

Output: a prospective study of complication rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is exercise testing used for?. ### Response: a prospective study of complication rates.


Instruction: What is testing to evaluate the indication for surgery in asymptomatic patients with valvular aortic stenosis?

Output: Value of exercise testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is testing to evaluate the indication for surgery in asymptomatic patients with valvular aortic stenosis?. ### Response: Value of exercise testing.


Instruction: What did Takeda S, Rimington H, Chambers J. Comparing pressure drop/flow slope and haemodynamic measures at rest?

Output: Prediction of symptom-onset

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Takeda S, Rimington H, Chambers J. Comparing pressure drop/flow slope and haemodynamic measures at rest?. ### Response: Prediction of symptom-onset.


Instruction: What are all common in kidney failure and are themselves associated with a high risk of adverse outcomes?

Output: 20,21

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are all common in kidney failure and are themselves associated with a high risk of adverse outcomes?. ### Response: 20,21.


Instruction: Patients with one of these three conditions are more likely to also have what?

Output: lowcholesterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with one of these three conditions are more likely to also have what?. ### Response: lowcholesterol.


Instruction: What confounds the apparent association between cholesterol and the risk of cardiovascular death?

Output: lowcholesterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What confounds the apparent association between cholesterol and the risk of cardiovascular death?. ### Response: lowcholesterol.


Instruction: What is increased in dialysis patients with higher LDL-C and TC?

Output: cardiovascular risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is increased in dialysis patients with higher LDL-C and TC?. ### Response: cardiovascular risk.


Instruction: What is unsuitable as the criterion for statin prescription in patients with kidney failure?

Output: elevated cholesterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is unsuitable as the criterion for statin prescription in patients with kidney failure?. ### Response: elevated cholesterol.


Instruction: What is the hazardratio of incident myo-cardial infarction associated with LDL-C 44.9 mmol/l[4190 mg/dl]?

Output: 95% conﬁdence interval [CI])

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the hazardratio of incident myo-cardial infarction associated with LDL-C 44.9 mmol/l[4190 mg/dl]?. ### Response: 95% conﬁdence interval [CI]).


Instruction: What is the MI associated with LDL-C 44.9 mmol/l[4190 mg/dl]?

Output: incident myo-cardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the MI associated with LDL-C 44.9 mmol/l[4190 mg/dl]?. ### Response: incident myo-cardial infarction.


Instruction: What are the eGFRs of Z90, 60-89.9 and 15-59.9 ml/min/1.73 m2?

Output: 60–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the eGFRs of Z90, 60-89.9 and 15-59.9 ml/min/1.73 m2?. ### Response: 60–.


Instruction: What is the relation between LDL-C and the risk of hospitalization forMI for selected values of baseline eGFR?

Output: lation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the relation between LDL-C and the risk of hospitalization forMI for selected values of baseline eGFR?. ### Response: lation.


Instruction: What does the figure show?

Output: therelation between LDL-C and the risk of hospitalization forMI for selected values of baseline eGFR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the figure show?. ### Response: therelation between LDL-C and the risk of hospitalization forMI for selected values of baseline eGFR.


Instruction: At what level does the relation appear linear?

Output: LDL-C above 2.6 mmol/l

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: At what level does the relation appear linear?. ### Response: LDL-C above 2.6 mmol/l.


Instruction: The HR (95% CI) of MI associated with each1 mmol/l (39 mg/dl) increase in what?

Output: LDL-C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The HR (95% CI) of MI associated with each1 mmol/l (39 mg/dl) increase in what?. ### Response: LDL-C.


Instruction: What is the MI associated with each1 mmol/l increase in LDL-C?

Output: 1.48

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the MI associated with each1 mmol/l increase in LDL-C?. ### Response: 1.48.


Instruction: What is a weaker and potentially misleading associa-tion between people with eGFR of 90, 60, 45, and 30?

Output: elevated cholesterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a weaker and potentially misleading associa-tion between people with eGFR of 90, 60, 45, and 30?. ### Response: elevated cholesterol.


Instruction: What is the ratio of LDL-C and coronary risk among those withlower levels of kidney function?

Output: misleading associa-tion between LDL-C and coronary risk among those withlower levels of kidney function (a group who is at the highestabsolute risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ratio of LDL-C and coronary risk among those withlower levels of kidney function?. ### Response: misleading associa-tion between LDL-C and coronary risk among those withlower levels of kidney function (a group who is at the highestabsolute risk.


Instruction: What group is at the highestabsolute risk for CKD?

Output: lower levels of kidney function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What group is at the highestabsolute risk for CKD?. ### Response: lower levels of kidney function.


Instruction: Who should receive pharmacological cholesterol-lowering treatment?

Output: CKDpatients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should receive pharmacological cholesterol-lowering treatment?. ### Response: CKDpatients.


Instruction: What should CKD patients receive?

Output: pharmacological cholesterol-lowering treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should CKD patients receive?. ### Response: pharmacological cholesterol-lowering treatment.


Instruction: How many potentialdeterminants of the decision to prescribe lipid-loweringtreatment in people with normal kidney function?

Output: three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many potentialdeterminants of the decision to prescribe lipid-loweringtreatment in people with normal kidney function?. ### Response: three.


Instruction: What is the baselinecoronary risk?

Output: hospitalization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the baselinecoronary risk?. ### Response: hospitalization.


Instruction: What is evidence that lipid-lowering treatment is beneficial?

Output: Baseline coronary risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is evidence that lipid-lowering treatment is beneficial?. ### Response: Baseline coronary risk.


Instruction: What is the baseline coronary risk?

Output: 10-year incidence risk ofcoronary death or non-fatal MI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the baseline coronary risk?. ### Response: 10-year incidence risk ofcoronary death or non-fatal MI.


Instruction: How long is the incidence risk of non-fatal MI?

Output: 10-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the incidence risk of non-fatal MI?. ### Response: 10-year.


Instruction: What will prompt evaluation by the Task Force?

Output: Publication of new, potentially practice-changing study results

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will prompt evaluation by the Task Force?. ### Response: Publication of new, potentially practice-changing study results.


Instruction: Who will consult with the relevant guideline writing committee to determine whether a focused update should be commissioned?

Output: the Task Force

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who will consult with the relevant guideline writing committee to determine whether a focused update should be commissioned?. ### Response: the Task Force.


Instruction: What should be commissioned?

Output: a focused update

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be commissioned?. ### Response: a focused update.


Instruction: What does the Task Force strive to avoid by selecting experts from a broad array of?

Output: bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Task Force strive to avoid by selecting experts from a broad array of?. ### Response: bias.


Instruction: What are the members of the writing committee representing?

Output: different geographic regions, sexes, eth-nicities, races, intellectual perspectives/biases, and scopes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the members of the writing committee representing?. ### Response: different geographic regions, sexes, eth-nicities, races, intellectual perspectives/biases, and scopes.


Instruction: When will the ahajournals.org be available?

Output: May 3, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When will the ahajournals.org be available?. ### Response: May 3, 2023.


Instruction: What is the VA/DoD CLINICAL PRACTICE GUIDELINE FOR THE DIAGNOSIS AND MANAGEMENT OF HYPERTENSION IN THE PRIMARY CARE SETTING?

Output: TRICARE policy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD CLINICAL PRACTICE GUIDELINE FOR THE DIAGNOSIS AND MANAGEMENT OF HYPERTENSION IN THE PRIMARY CARE SETTING?. ### Response: TRICARE policy.


Instruction: What is based on the best information available at the time of publication?

Output: The Department of Veterans Affairs and the Department of Defense guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is based on the best information available at the time of publication?. ### Response: The Department of Veterans Affairs and the Department of Defense guidelines.


Instruction: What is not intended to define a standard of care and should not be interpreted as one?

Output: The Department of Veterans Affairs and the Department of Defense guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not intended to define a standard of care and should not be interpreted as one?. ### Response: The Department of Veterans Affairs and the Department of Defense guidelines.


Instruction: What should they be interpreted as prescribing?

Output: Department of Veterans Affairs or TRICARE policy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should they be interpreted as prescribing?. ### Response: Department of Veterans Affairs or TRICARE policy.


Instruction: What is based on a systematic review of both clinical and epidemiological evidence?

Output: Clinical Practice Guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is based on a systematic review of both clinical and epidemiological evidence?. ### Response: Clinical Practice Guideline.


Instruction: Who developed the Clinical Practice Guideline?

Output: a panel of multidisciplinary experts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who developed the Clinical Practice Guideline?. ### Response: a panel of multidisciplinary experts.


Instruction: What do clinicians need to take into account in order for variations in practice to occur?

Output: the needs of individual patients, available resources, and limitations unique to an institution or type of practice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do clinicians need to take into account in order for variations in practice to occur?. ### Response: the needs of individual patients, available resources, and limitations unique to an institution or type of practice.


Instruction: What is the purpose of a clinician's explanation of the logical relationships between care options and health outcomes?

Output: rating both the quality of the evidence and the strength of the recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of a clinician's explanation of the logical relationships between care options and health outcomes?. ### Response: rating both the quality of the evidence and the strength of the recommendation.


Instruction: Who is responsible for evaluating the appropriateness of applying these guidelines in the setting of any particular clinical situation?

Output: Every healthcare professional

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is responsible for evaluating the appropriateness of applying these guidelines in the setting of any particular clinical situation?. ### Response: Every healthcare professional.


Instruction: These guidelines are not intended to represent what?

Output: Department of Veterans Affairs or TRICARE policy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: These guidelines are not intended to represent what?. ### Response: Department of Veterans Affairs or TRICARE policy.


Instruction: What does not guarantee coverage of civilian sector care?

Output: inclusion of rec ommendations for specific testing and/or therapeutic interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not guarantee coverage of civilian sector care?. ### Response: inclusion of rec ommendations for specific testing and/or therapeutic interventions.


Instruction: Where can additional information on current TRICARE benefits be found?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can additional information on current TRICARE benefits be found?. ### Response: www.tricare.mil.


Instruction: Where can you find information on current TRICARE benefits?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find information on current TRICARE benefits?. ### Response: www.tricare.mil.


Instruction: What is the name of the organization that can provide information on TRIcare?

Output: TRICARE Managed Care Support Contractor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that can provide information on TRIcare?. ### Response: TRICARE Managed Care Support Contractor.


Instruction: How long is version 4.0 to 2020?

Output: 2020

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is version 4.0 to 2020?. ### Response: 2020.


Instruction: Litus plus chronic kidney disease or prevalent CVD did not find evidence that aliskiren reduced cardiovascular end points, including what?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Litus plus chronic kidney disease or prevalent CVD did not find evidence that aliskiren reduced cardiovascular end points, including what?. ### Response: stroke.


Instruction: The benefits of lowering BP as a means to prevent stroke are undisputed, but there is no definitive evidence that any particular class of what offers benefits?

Output: anti-hypertensive agents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The benefits of lowering BP as a means to prevent stroke are undisputed, but there is no definitive evidence that any particular class of what offers benefits?. ### Response: anti-hypertensive agents.


Instruction: What can be achieved in most patients, but most patients require therapy with 2?

Output: BP control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be achieved in most patients, but most patients require therapy with 2?. ### Response: BP control.


Instruction: What is warranted to test differences in efficacy of individual agents in subgroups of patients?

Output: hypothesis-driven trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is warranted to test differences in efficacy of individual agents in subgroups of patients?. ### Response: hypothesis-driven trials.


Instruction: What do most patients require therapy with?

Output: ≥2 drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do most patients require therapy with?. ### Response: ≥2 drugs.


Instruction: What did a thiazide diuretic significantly reduce the risk of in patients taking a calcium channel blocker?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a thiazide diuretic significantly reduce the risk of in patients taking a calcium channel blocker?. ### Response: stroke.


Instruction: What did the combination of a calcium channel blocker and thiazide not show for other cardiovascular end points?

Output: The advantage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the combination of a calcium channel blocker and thiazide not show for other cardiovascular end points?. ### Response: The advantage.


Instruction: What does more intensive control of BP support?

Output: reduces risk of stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does more intensive control of BP support?. ### Response: reduces risk of stroke.


Instruction: What reduces the risk of stroke more than less intensive control?

Output: more intensive control of BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What reduces the risk of stroke more than less intensive control?. ### Response: more intensive control of BP.


Instruction: What does more intensive control of BP reduce risk of?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does more intensive control of BP reduce risk of?. ### Response: stroke.


Instruction: Who developed the NICE guideline?

Output: 31 3.3.1  What this guideline covers  ................................ ................................ .....................  31 3.3.2  What this guideline does not cover

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who developed the NICE guideline?. ### Response: 31 3.3.1  What this guideline covers  ................................ ................................ .....................  31 3.3.2  What this guideline does not cover.


Instruction: What does this guideline not cover?

Output: Relationships

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does this guideline not cover?. ### Response: Relationships.


Instruction: How many 3.3.3 Relationships between the guideline and other NICE guidance?

Output: 32

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many 3.3.3 Relationships between the guideline and other NICE guidance?. ### Response: 32.


Instruction: What is the main difference between the NICE guideline and other NICE guidance?

Output: Relationships

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the main difference between the NICE guideline and other NICE guidance?. ### Response: Relationships.


Instruction: What are the main differences between NICE and NICE?

Output: Relationships

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the main differences between NICE and NICE?. ### Response: Relationships.


Instruction: How are review questions and outcomes developed?

Output: Methods

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are review questions and outcomes developed?. ### Response: Methods.


Instruction: What type of literature search is used in 41 4.2.1 Clinical literature search?

Output: Health economic literature search

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of literature search is used in 41 4.2.1 Clinical literature search?. ### Response: Health economic literature search.


Instruction: What is one of the criteria used in 42 4.3.1 Inclusion and exclusion criteria?

Output: Identifying and analysing evidence of effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the criteria used in 42 4.3.1 Inclusion and exclusion criteria?. ### Response: Identifying and analysing evidence of effectiveness.


Instruction: What are inclusion and exclusion criteria?

Output: Type of studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are inclusion and exclusion criteria?. ### Response: Type of studies.


Instruction: What are methods of combining clinical studies called?

Output: Type of studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are methods of combining clinical studies called?. ### Response: Type of studies.


Instruction: How is the quality of evidence assessed?

Output: by outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the quality of evidence assessed?. ### Response: by outcomes.


Instruction: What is evidence by outcomes?

Output: Appraising the quality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is evidence by outcomes?. ### Response: Appraising the quality.


Instruction: What is publication bias?

Output: Assessing clinical importance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is publication bias?. ### Response: Assessing clinical importance.


Instruction: How is clinical importance assessed?

Output: Publication bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is clinical importance assessed?. ### Response: Publication bias.


Instruction: What is the current status of transcatheter aortic valve replacement?

Output: Coronary hemodynamics in patients with severe aortic stenosis and coronary artery disease undergoing trans-catheter aortic valve replacement: implications for clinical indices of coro-nary stenosis severity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the current status of transcatheter aortic valve replacement?. ### Response: Coronary hemodynamics in patients with severe aortic stenosis and coronary artery disease undergoing trans-catheter aortic valve replacement: implications for clinical indices of coro-nary stenosis severity.


Instruction: What type of stenosis is associated with severe coronary artery disease?

Output: aortic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of stenosis is associated with severe coronary artery disease?. ### Response: aortic.


Instruction: In what year was the JACC state-of-the-art review published?

Output: 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was the JACC state-of-the-art review published?. ### Response: 2018.


Instruction: What is the association between severe aortic stenosis and coronary artery disease?

Output: Coronary hemodynamics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association between severe aortic stenosis and coronary artery disease?. ### Response: Coronary hemodynamics.


Instruction: What year did J Am Coll Cardiol. 2012:62:1-10?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did J Am Coll Cardiol. 2012:62:1-10?. ### Response: 2013.


Instruction: How long did coro-nary arterial disease affect mortality in patients?

Output: 30-day and 1-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did coro-nary arterial disease affect mortality in patients?. ### Response: 30-day and 1-year.


Instruction: What is the effect of coro-nary artery disease on mortality in patients undergoing transcatheter aortic valve replacement?

Output: 30-day and 1-year mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of coro-nary artery disease on mortality in patients undergoing transcatheter aortic valve replacement?. ### Response: 30-day and 1-year mortality.


Instruction: How long did it take for patients to die from coro nary arterial disease?

Output: 30-day and 1-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for patients to die from coro nary arterial disease?. ### Response: 30-day and 1-year.


Instruction: What was the name of the meta-analysis that looked at the effects of coronary arteries on mortality?

Output: CTCA for detection of significant coronary artery disease in routine TAVI work-up: A systematic review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the meta-analysis that looked at the effects of coronary arteries on mortality?. ### Response: CTCA for detection of significant coronary artery disease in routine TAVI work-up: A systematic review.


Instruction: In what year did the J Am Heart Assoc. 2017:6:e006092?

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did the J Am Heart Assoc. 2017:6:e006092?. ### Response: 2017.


Instruction: What is the name of the registry that provides real-world results for aortic valve re-placement?

Output: East Denmark Heart Registry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the registry that provides real-world results for aortic valve re-placement?. ### Response: East Denmark Heart Registry.


Instruction: What are the prognostic effects of coronary disease severity and completeness of revascularization on?

Output: mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the prognostic effects of coronary disease severity and completeness of revascularization on?. ### Response: mortality.


Instruction: What is the name of the procedure used in place of invasive coronary angiography in patients undergoing transcatheter aortic valve replacement?

Output: computed tomographic coronary angiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the procedure used in place of invasive coronary angiography in patients undergoing transcatheter aortic valve replacement?. ### Response: computed tomographic coronary angiography.


Instruction: What year did JACC Cardio-vasc Interv. 2017:10:1428–35?

Output: 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did JACC Cardio-vasc Interv. 2017:10:1428–35?. ### Response: 2018.


Instruction: What year did Circ Cardiovasc Interv publish 8:e002025?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Circ Cardiovasc Interv publish 8:e002025?. ### Response: 2015.


Instruction: What does CT angiography do to evaluate coronary artery disease?

Output: evalu-ate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CT angiography do to evaluate coronary artery disease?. ### Response: evalu-ate.


Instruction: What is CTCA used for in routine TAVI work-up?

Output: detection of significant coronary artery disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CTCA used for in routine TAVI work-up?. ### Response: detection of significant coronary artery disease.


Instruction: What is the name of the systematic review and meta-analysis of CTCA for detection of significant coronary artery disease?

Output: A systematic review and meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta-analysis of CTCA for detection of significant coronary artery disease?. ### Response: A systematic review and meta-analysis.


Instruction: What is the influence of pressure overload on the evaluation of lesions severity?

Output: Functional assessment of coro-nary artery disease in patients undergoing transcatheter aortic valve im-plantation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the influence of pressure overload on the evaluation of lesions severity?. ### Response: Functional assessment of coro-nary artery disease in patients undergoing transcatheter aortic valve im-plantation.


Instruction: What are patients with severe aortic stenosis and coronary artery disease undergoing?

Output: trans-catheter aortic valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients with severe aortic stenosis and coronary artery disease undergoing?. ### Response: trans-catheter aortic valve replacement.


Instruction: What are implications for clinical indices of coro-nary stenosis severity?

Output: Coronary hemodynamics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are implications for clinical indices of coro-nary stenosis severity?. ### Response: Coronary hemodynamics.


Instruction: What is the JACC Cardiovasc Interv. 2018;11:2019-31?

Output: Instantaneous

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the JACC Cardiovasc Interv. 2018;11:2019-31?. ### Response: Instantaneous.


Instruction: Yamanaka F, Shishido K, Ochiai T, et al. What is instantaneous wave-free ratio for?

Output: the assessment of intermediate coronary artery stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Yamanaka F, Shishido K, Ochiai T, et al. What is instantaneous wave-free ratio for?. ### Response: the assessment of intermediate coronary artery stenosis.


Instruction: What is the difference between myocardial perfusion scintig-raphy and artery stenosis?

Output: Instantaneous wave-free ratio

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between myocardial perfusion scintig-raphy and artery stenosis?. ### Response: Instantaneous wave-free ratio.


Instruction: What is a common cause of angina pectoris and abnormal heart rhythms?

Output: artery disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a common cause of angina pectoris and abnormal heart rhythms?. ### Response: artery disease.


Instruction: What is reported if imprecision is a factor?

Output: Insufficient evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reported if imprecision is a factor?. ### Response: Insufficient evidence.


Instruction: What is the name of the nomenclature for grading recommendations?

Output: KDIGO

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the nomenclature for grading recommendations?. ### Response: KDIGO.


Instruction: What can be evaluatedas a candidate for developing a policy or a performance measure?

Output: The recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be evaluatedas a candidate for developing a policy or a performance measure?. ### Response: The recommendation.


Instruction: How many people in your situation would want the recommended course of action but many would not?

Output: The majority

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people in your situation would want the recommended course of action but many would not?. ### Response: The majority.


Instruction: How does each patient need help to arrive at a management decision?

Output: consistentw

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does each patient need help to arrive at a management decision?. ### Response: consistentw.


Instruction: What is likely to requiresubstantial debate and involvement of stakeholders before policy can be made?

Output: The recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is likely to requiresubstantial debate and involvement of stakeholders before policy can be made?. ### Response: The recommendation.


Instruction: What category was used to provide guidance based on common sense or where the topic does not allow adequate application of evidence?

Output: Not Graded

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What category was used to provide guidance based on common sense or where the topic does not allow adequate application of evidence?. ### Response: Not Graded.


Instruction: What are some examples of recommendations regarding monitoring intervals?

Output: counseling, and referral to other clinical specialists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some examples of recommendations regarding monitoring intervals?. ### Response: counseling, and referral to other clinical specialists.


Instruction: What are recommendations regarding monitoring intervals, counseling, and referral to other clinical specialists?

Output: The most common examples

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are recommendations regarding monitoring intervals, counseling, and referral to other clinical specialists?. ### Response: The most common examples.


Instruction: The ung raded recommendations are generally written as what?

Output: simple declarative statements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The ung raded recommendations are generally written as what?. ### Response: simple declarative statements.


Instruction: What determines the strength of a recommendation?

Output: Balance between desirable andundesirable effectsThe larger the difference between the desirable and undesirable effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What determines the strength of a recommendation?. ### Response: Balance between desirable andundesirable effectsThe larger the difference between the desirable and undesirable effects.


Instruction: The larger the difference between the desirable and undesirable effects, the more likely a strong recommendation is warranted.

Output: Level 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The larger the difference between the desirable and undesirable effects, the more likely a strong recommendation is warranted.. ### Response: Level 2.


Instruction: The narrower the gradient, the less likely is a weak recommendation is?

Output: many would not

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The narrower the gradient, the less likely is a weak recommendation is?. ### Response: many would not.


Instruction: What is the higher the quality of evidence?

Output: more likely a strong recommendation is warranted

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the higher the quality of evidence?. ### Response: more likely a strong recommendation is warranted.


Instruction: The higher the quality of evidence, the more likely a strong recommendation is warranted what?

Output: Quality of the evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The higher the quality of evidence, the more likely a strong recommendation is warranted what?. ### Response: Quality of the evidence.


Instruction: The more variability in values and preferences, or the more uncertainty in value and preferences is, what is more likely?

Output: a weak recommendation is warranted

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The more variability in values and preferences, or the more uncertainty in value and preferences is, what is more likely?. ### Response: a weak recommendation is warranted.


Instruction: Values and preferences were obtained from the literature where?

Output: possible

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Values and preferences were obtained from the literature where?. ### Response: possible.


Instruction: What was obtained from the literature where possible?

Output: Values and preferences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was obtained from the literature where possible?. ### Response: Values and preferences.


Instruction: What was assessed in the judgment of the Work Group where robust evidence was not identified?

Output: Values and preferences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was assessed in the judgment of the Work Group where robust evidence was not identified?. ### Response: Values and preferences.


Instruction: The higher the costs of an intervention, the more resources consumed, the less likely a strong recommendation is warranted?

Output: debate and involvement ofstakeholders

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The higher the costs of an intervention, the more resources consumed, the less likely a strong recommendation is warranted?. ### Response: debate and involvement ofstakeholders.


Instruction: What is less likely a strongrecommendation is warranted?

Output: The higher the costs of an intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is less likely a strongrecommendation is warranted?. ### Response: The higher the costs of an intervention.


Instruction: What prevents stent thrombosis?

Output: Stroke prevention, necessitating OAC, whether withVKA or NOAC./C15Prevention of stent thrombosis, necessitating APT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What prevents stent thrombosis?. ### Response: Stroke prevention, necessitating OAC, whether withVKA or NOAC./C15Prevention of stent thrombosis, necessitating APT.


Instruction: How long is DAPT effective in non-AF patients?

Output: up to 12 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is DAPT effective in non-AF patients?. ### Response: up to 12 months.


Instruction: What is another name for dual antiplatelet therapy?

Output: DAPT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for dual antiplatelet therapy?. ### Response: DAPT.


Instruction: How long is DAPT used in non-AF patients?

Output: up to 12 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is DAPT used in non-AF patients?. ### Response: up to 12 months.


Instruction: What is the risk of more bleeding in patients with prior heart attack using Ticagrelor compared to Pla-cebo?

Output: Pla-cebo on a Background of Aspirin-Thrombolysis inMyocardial Infarction 54 (PEGASUS-TIMI 54)trials, to reduce nonstent-related ischemic andstroke events, but at the risk of more bleedingevents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of more bleeding in patients with prior heart attack using Ticagrelor compared to Pla-cebo?. ### Response: Pla-cebo on a Background of Aspirin-Thrombolysis inMyocardial Infarction 54 (PEGASUS-TIMI 54)trials, to reduce nonstent-related ischemic andstroke events, but at the risk of more bleedingevents.


Instruction: What is a serious bleeding risk with the combination of OAC and one or more antiplatelet drugs?

Output: ICH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a serious bleeding risk with the combination of OAC and one or more antiplatelet drugs?. ### Response: ICH.


Instruction: What can be assessed byvarious bleeding risk scores?

Output: Bleeding risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be assessed byvarious bleeding risk scores?. ### Response: Bleeding risk.


Instruction: What is predictive of bleeding in the setting ofACS and/or PCI-stenting?

Output: HAS-BLED score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is predictive of bleeding in the setting ofACS and/or PCI-stenting?. ### Response: HAS-BLED score.


Instruction: Small strut sizes necessitate shorter duration of what?

Output: DAPT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Small strut sizes necessitate shorter duration of what?. ### Response: DAPT.


Instruction: What may offer a better safety pro file than VKA-based therapy?

Output: NOACs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may offer a better safety pro file than VKA-based therapy?. ### Response: NOACs.


Instruction: What may be relatively safe in the presence of well-managed anticoagulation control with high TTR?

Output: thelatter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be relatively safe in the presence of well-managed anticoagulation control with high TTR?. ### Response: thelatter.


Instruction: What type of anticoagulation control has a high TTR?

Output: well-managed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of anticoagulation control has a high TTR?. ### Response: well-managed.


Instruction: How many cases have been reported of AF patients undergoing PCI/stenting?

Output: 279

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many cases have been reported of AF patients undergoing PCI/stenting?. ### Response: 279.


Instruction: What are the joint Europeanconsensus documents?

Output: 2014 and 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the joint Europeanconsensus documents?. ### Response: 2014 and 2018.


Instruction: RhythmSociety and the Asia-Paci fic Heart Rhythm Society provide consensus recommendations on what?

Output: optimalmanagement of such patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: RhythmSociety and the Asia-Paci fic Heart Rhythm Society provide consensus recommendations on what?. ### Response: optimalmanagement of such patients.


Instruction: A similar North American expert consensus document has been published.

Output: 92,277

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A similar North American expert consensus document has been published.. ### Response: 92,277.


Instruction: What is a high thrombotic risk/low bleeding risk?

Output: Time fromtreatmentInitiation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a high thrombotic risk/low bleeding risk?. ### Response: Time fromtreatmentInitiation.


Instruction: What is an low bleeding risk type of therapy?

Output: low thrombotic/high bleeding risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an low bleeding risk type of therapy?. ### Response: low thrombotic/high bleeding risk.


Instruction: How many mo is possible for a triple therapy in patients with balanced blood pressure?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mo is possible for a triple therapy in patients with balanced blood pressure?. ### Response: 3.


Instruction: What is the thrombotic/bleeding risk of oral antiplatelet therapy?

Output: balanced

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the thrombotic/bleeding risk of oral antiplatelet therapy?. ### Response: balanced.


Instruction: What are the abbreviations in Figure 1?

Output: high thrombotic/low bleeding risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the abbreviations in Figure 1?. ### Response: high thrombotic/low bleeding risk.


Instruction: Where is Evidence-Based Medicine adapted from?

Output: Angiolillo et al.202

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Evidence-Based Medicine adapted from?. ### Response: Angiolillo et al.202.


Instruction: What is an example of myocardial ischemia?

Output: high-risk criteria on stresstesting, abnormal intracoronary hemodynamic eval-uation, or >20% perfusion defect by myocardialperfusion stress imaging) or target vessels supplyinga large area of viable myocardium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of myocardial ischemia?. ### Response: high-risk criteria on stresstesting, abnormal intracoronary hemodynamic eval-uation, or >20% perfusion defect by myocardialperfusion stress imaging) or target vessels supplyinga large area of viable myocardium.


Instruction: What is the level of evidence for CABG in patients with mild-moderate left ventricular systolicdysfunction?

Output: reasonable

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the level of evidence for CABG in patients with mild-moderate left ventricular systolicdysfunction?. ### Response: reasonable.


Instruction: What is LV systolicdysfunction?

Output: EF <35%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is LV systolicdysfunction?. ### Response: EF <35%).


Instruction: What is significant (>70% diameter stenosis) when viable myocardium is present in the region ofntended revascularization?

Output: multi-vesselCAD or proximal LAD coronary artery stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is significant (>70% diameter stenosis) when viable myocardium is present in the region ofntended revascularization?. ### Response: multi-vesselCAD or proximal LAD coronary artery stenosis.


Instruction: What type of graft is reasonable in patients with significant stenosis in theproximal LAD artery and evidence of extensiveischemia?

Output: CABG with a left internal mammary artery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of graft is reasonable in patients with significant stenosis in theproximal LAD artery and evidence of extensiveischemia?. ### Response: CABG with a left internal mammary artery.


Instruction: What is reasonable to choose CABG over PCI to im-prove survival?

Output: patients with complex 3-vesselCAD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable to choose CABG over PCI to im-prove survival?. ### Response: patients with complex 3-vesselCAD.


Instruction: What is a good candidate for CABG?

Output: complex 3-vesselCAD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a good candidate for CABG?. ### Response: complex 3-vesselCAD.


Instruction: Why is CABG preferred over PCI?

Output: to improve survival in patients with multivesselCAD and diabetes mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is CABG preferred over PCI?. ### Response: to improve survival in patients with multivesselCAD and diabetes mellitus.


Instruction: What can be anastomosed to the LIMAgraft?

Output: LIMAgraft

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be anastomosed to the LIMAgraft?. ### Response: LIMAgraft.


Instruction: What can be anastomosed to the LAD artery?

Output: LIMAgraft

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be anastomosed to the LAD artery?. ### Response: LIMAgraft.


Instruction: What is the usefulness of CABG to improve survival in patients with significant diameter stenoses?

Output: uncertain

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the usefulness of CABG to improve survival in patients with significant diameter stenoses?. ### Response: uncertain.


Instruction: What type of CAD can improve survival in patients with 2- or 3-vessel CAD?

Output: PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of CAD can improve survival in patients with 2- or 3-vessel CAD?. ### Response: PCI.


Instruction: What kind of proximal LAD disease can be treated with PCI?

Output: 1-vessel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What kind of proximal LAD disease can be treated with PCI?. ### Response: 1-vessel.


Instruction: What might be considered with the primary or soleintent of improving survival in patients with SIHD with severe LV systolic dysfunction?

Output: CABG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What might be considered with the primary or soleintent of improving survival in patients with SIHD with severe LV systolic dysfunction?. ### Response: CABG.


Instruction: What is the level of evidence for CABG or PCI?

Output: B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the level of evidence for CABG or PCI?. ### Response: B.


Instruction: What is the class of evidence for CABG or PCI?

Output: B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the class of evidence for CABG or PCI?. ### Response: B.


Instruction: What should not be performed with the sole intent to improve survival in patients with SIHD with 1 or more coronary stenosesthat are not anatomically or functionally significant?

Output: CABG or PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not be performed with the sole intent to improve survival in patients with SIHD with 1 or more coronary stenosesthat are not anatomically or functionally significant?. ### Response: CABG or PCI.


Instruction: What type of stenosesthat are not anatomically or functionally significant?

Output: coronary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of stenosesthat are not anatomically or functionally significant?. ### Response: coronary.


Instruction: What is involved only the left circumflexor right coronary artery?

Output: coronary stenosest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is involved only the left circumflexor right coronary artery?. ### Response: coronary stenosest.


Instruction: Revascularization to ImproveSymptoms: RecommendationsClass I1. What is beneficial inpatients with 1 or more significant coronary artery stenoses amenable to revasculariza-tion and unacceptable angina despite GDMT?

Output: CABG or PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Revascularization to ImproveSymptoms: RecommendationsClass I1. What is beneficial inpatients with 1 or more significant coronary artery stenoses amenable to revasculariza-tion and unacceptable angina despite GDMT?. ### Response: CABG or PCI.


Instruction: What is Chronic Heart Failure Treating?

Output: Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Chronic Heart Failure Treating?. ### Response: Heart Failure.


Instruction: What is the name of the book that treats heart failure?

Output: Chronic He art Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the book that treats heart failure?. ### Response: Chronic He art Failure.


Instruction: What was the risk of bias, imprecision, and inconsistency in the evidence?

Output: very low quality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk of bias, imprecision, and inconsistency in the evidence?. ### Response: very low quality.


Instruction: What was rated as very low quality for mortality?

Output: Oral iron versus placebo:  For mortality the evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was rated as very low quality for mortality?. ### Response: Oral iron versus placebo:  For mortality the evidence.


Instruction: What was the larger of the 2 studies showing a negative effect of oral iron?

Output: single study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the larger of the 2 studies showing a negative effect of oral iron?. ### Response: single study.


Instruction: Why was the outcome improvement in NYHA class rated as low quality?

Output: risk of bias, indirectness (as t his was interpreted as a surrogate for QoL as it implies an improvement in symptoms) and imprecision

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the outcome improvement in NYHA class rated as low quality?. ### Response: risk of bias, indirectness (as t his was interpreted as a surrogate for QoL as it implies an improvement in symptoms) and imprecision.


Instruction: What was interpreted as a surrogate for QoL as it implies an improvement in symptoms?

Output: indirectness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was interpreted as a surrogate for QoL as it implies an improvement in symptoms?. ### Response: indirectness.


Instruction: What reduced the committees ability to be confident in the results?

Output: confidence intervals surrounding the effect estimate were wide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What reduced the committees ability to be confident in the results?. ### Response: confidence intervals surrounding the effect estimate were wide.


Instruction: What did the committee grade the evidence regarding discontinuation and adverse events and serious adverse events as?

Output: low and very low quality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee grade the evidence regarding discontinuation and adverse events and serious adverse events as?. ### Response: low and very low quality.


Instruction: Why was evidence graded as low and very low quality?

Output: risk of bias and imprecision

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was evidence graded as low and very low quality?. ### Response: risk of bias and imprecision.


Instruction: What were the adverse event outcomes downgraded for?

Output: indirectness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the adverse event outcomes downgraded for?. ### Response: indirectness.


Instruction: Why were these events downgraded for indirectness?

Output: lack of description

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why were these events downgraded for indirectness?. ### Response: lack of description.


Instruction: What made it difficult for the committee to interpret this evidence?

Output: lack of description

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What made it difficult for the committee to interpret this evidence?. ### Response: lack of description.


Instruction: The committee agreed that discontinuation and adverse event rates appeared low with what?

Output: oral iron

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committee agreed that discontinuation and adverse event rates appeared low with what?. ### Response: oral iron.


Instruction: What was the difference between placebo and placebo for all 3 outcomes?

Output: less than 50 per 1000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the difference between placebo and placebo for all 3 outcomes?. ### Response: less than 50 per 1000.


Instruction: What was not identified for anaphylaxis or hypersensitivity?

Output: evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not identified for anaphylaxis or hypersensitivity?. ### Response: evidence.


Instruction: Peak VO2, 6 minute walk test distance and KCCQ clinical summary score were reported as what?

Output: median and IQR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Peak VO2, 6 minute walk test distance and KCCQ clinical summary score were reported as what?. ### Response: median and IQR.


Instruction: What was not reported by the study as median and IQR?

Output: The evidence for peak VO2, 6 minute walk test distance and KCCQ clinical summary score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not reported by the study as median and IQR?. ### Response: The evidence for peak VO2, 6 minute walk test distance and KCCQ clinical summary score.


Instruction: What could not be assessed?

Output: imprec ision

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could not be assessed?. ### Response: imprec ision.


Instruction: The populations in the included trials was not representative of what?

Output: the general HF population

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The populations in the included trials was not representative of what?. ### Response: the general HF population.


Instruction: The committee was unsure how the benefit seen in the trials would translate in the general HF population?

Output: confident

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committee was unsure how the benefit seen in the trials would translate in the general HF population?. ### Response: confident.


Instruction: The committee discussed whether the trials had been long enough to encompass the possible risks and benefits.

Output: It was also discussed whether the trials had been long enough to encompass the possible risks and benefits.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committee discussed whether the trials had been long enough to encompass the possible risks and benefits.. ### Response: It was also discussed whether the trials had been long enough to encompass the possible risks and benefits..


Instruction: The committee noted that the trials had only included people with what type of fract ion?

Output: reduced ejection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committee noted that the trials had only included people with what type of fract ion?. ### Response: reduced ejection.


Instruction: People with iron deficiency and HFPEF did not have what?

Output: evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: People with iron deficiency and HFPEF did not have what?. ### Response: evidence.


Instruction: What was the trade-off between clinical benefits and harms?

Output: IV iron

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the trade-off between clinical benefits and harms?. ### Response: IV iron.


Instruction: What did IV iron do for people with HFREF and iron deficiency have a clinically important benefit on?

Output: quality of life and haemoglobin levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did IV iron do for people with HFREF and iron deficiency have a clinically important benefit on?. ### Response: quality of life and haemoglobin levels.


Instruction: What was unclear about the impact of IV iron on mortality?

Output: very low quality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was unclear about the impact of IV iron on mortality?. ### Response: very low quality.


Instruction: The committee noted that the point estimate showed what?

Output: a clinically imp ortant reduction in deaths

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committee noted that the point estimate showed what?. ### Response: a clinically imp ortant reduction in deaths.


Instruction: What were the confidence intervals around the absolute effect wide?

Output: reducing their confidence in the effect estimate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the confidence intervals around the absolute effect wide?. ### Response: reducing their confidence in the effect estimate.


Instruction: The effect estimate suggested a clinically important reduction in what?

Output: hospitalisations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The effect estimate suggested a clinically important reduction in what?. ### Response: hospitalisations.


Instruction: What are oral anticoagulants versus warfarin in patients with atrial fibrillation and valvular heart disease?

Output: Apixaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are oral anticoagulants versus warfarin in patients with atrial fibrillation and valvular heart disease?. ### Response: Apixaban.


Instruction: What is the name of the systematic review and meta-analysis in which anticoagulant is used in patients?

Output: ARISTOTLE trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta-analysis in which anticoagulant is used in patients?. ### Response: ARISTOTLE trial.


Instruction: When was the J Am Heart Assoc 2017 published?

Output: 6:e005835

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Heart Assoc 2017 published?. ### Response: 6:e005835.


Instruction: Atrial fibrillation and valvular heart disease: evaluating what in a nationwide cohort study?

Output: valvular heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atrial fibrillation and valvular heart disease: evaluating what in a nationwide cohort study?. ### Response: valvular heart disease.


Instruction: Europace. 2019;21: 33-40.

Output: 2. Lip GYH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Europace. 2019;21: 33-40.. ### Response: 2. Lip GYH.


Instruction: Vora AN, Dai D, Matsuoka R, et al. Incidence, management, and associated clinical outcomes of new-onset atrial fibrosis following transcath-eter aortic valve replacement: an analysis from what registry?

Output: STS/ACC TVT registry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Vora AN, Dai D, Matsuoka R, et al. Incidence, management, and associated clinical outcomes of new-onset atrial fibrosis following transcath-eter aortic valve replacement: an analysis from what registry?. ### Response: STS/ACC TVT registry.


Instruction: What is the STS/ACC TVT registry used for?

Output: an analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the STS/ACC TVT registry used for?. ### Response: an analysis.


Instruction: What does Apixaban do in patients with atrial fibrillation after transfemoral aortic valve replacement?

Output: preven-tion of thromboembolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Apixaban do in patients with atrial fibrillation after transfemoral aortic valve replacement?. ### Response: preven-tion of thromboembolism.


Instruction: Which type of anticoagulant type does Barbanti M have?

Output: Oral

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which type of anticoagulant type does Barbanti M have?. ### Response: Oral.


Instruction: What type of anticoagulant type and outcomes after transcatheter aortic valve replacement?

Output: Oral

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of anticoagulant type and outcomes after transcatheter aortic valve replacement?. ### Response: Oral.


Instruction: What is the JACC Cardiovasc Interv. 2019;12:1566–76?

Output: Oral anticoagulant type and outcomes after transcatheter aortic valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the JACC Cardiovasc Interv. 2019;12:1566–76?. ### Response: Oral anticoagulant type and outcomes after transcatheter aortic valve replacement.


Instruction: What is the impact of postoperative anticoagulant management on outcome in patients with atrial fibrillation?

Output: Continued versus interrupted oral anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact of postoperative anticoagulant management on outcome in patients with atrial fibrillation?. ### Response: Continued versus interrupted oral anticoagulation.


Instruction: What is Eikelboom JW, Connolly SJ, Brueckmann M, et al. Using Dabigatran ver -sus warfarin in mechanical heart valves?

Output: 7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Eikelboom JW, Connolly SJ, Brueckmann M, et al. Using Dabigatran ver -sus warfarin in mechanical heart valves?. ### Response: 7.


Instruction: What is the name of the ENGAGE AF-TIMI 48 trial?

Output: J Am Coll Car -diol. 2017;69

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the ENGAGE AF-TIMI 48 trial?. ### Response: J Am Coll Car -diol. 2017;69.


Instruction: What drug is used to prevent thromboembolism in patients with valvular heart disease?

Output: edoxaban or warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug is used to prevent thromboembolism in patients with valvular heart disease?. ### Response: edoxaban or warfarin.


Instruction: What is edoxaban used for in patients with atrial fibrillation and bioprosthetic valves?

Output: preven-tion of thromboembolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is edoxaban used for in patients with atrial fibrillation and bioprosthetic valves?. ### Response: preven-tion of thromboembolism.


Instruction: What is the Circulation 2017135:1273–5?

Output: Edoxaban for the preven-tion of thromboembolism in patients with atrial fibrillation and biopros-thetic valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Circulation 2017135:1273–5?. ### Response: Edoxaban for the preven-tion of thromboembolism in patients with atrial fibrillation and biopros-thetic valves.


Instruction: How does apixaban compare to war -farin?

Output: Efficacy and safety

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does apixaban compare to war -farin?. ### Response: Efficacy and safety.


Instruction: What is ARISTOTLE?

Output: Apixaban for Reduction in Stroke and Other Thromboem-bolic Events in Atrial Fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ARISTOTLE?. ### Response: Apixaban for Reduction in Stroke and Other Thromboem-bolic Events in Atrial Fibrillation.


Instruction: What is apixa-ban vs warfarin used for?

Output: Reduction in Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is apixa-ban vs warfarin used for?. ### Response: Reduction in Stroke.


Instruction: What did the ARISTOTLE trial provide insights from?

Output: Efficacy and safety of apixa-ban vs warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the ARISTOTLE trial provide insights from?. ### Response: Efficacy and safety of apixa-ban vs warfarin.


Instruction: What was the name of the study that provided insights into atrial fibrillation and valve repair?

Output: ARISTOTLE trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the study that provided insights into atrial fibrillation and valve repair?. ### Response: ARISTOTLE trial.


Instruction: How many patients were enrolled in the ARistOTLE study?

Output: 11

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were enrolled in the ARistOTLE study?. ### Response: 11.


Instruction: What is rivaroxaban vs. warfarin used for in patients with non-valvular atrial fibrillation?

Output: Native valve disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is rivaroxaban vs. warfarin used for in patients with non-valvular atrial fibrillation?. ### Response: Native valve disease.


Instruction: What is the name of the drug used to treat aortic valve disease?

Output: rivaroxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used to treat aortic valve disease?. ### Response: rivaroxaban.


Instruction: When is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction released?

Output: June 2020

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction released?. ### Response: June 2020.


Instruction: How old is the person in the Question Set # Concept Strategy Questions 9, 10, 11, 12?

Output: 104 of 127

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old is the person in the Question Set # Concept Strategy Questions 9, 10, 11, 12?. ### Response: 104 of 127.


Instruction: What is the name of the non-pharmacologic treatment?

Output: Dyslipidemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the non-pharmacologic treatment?. ### Response: Dyslipidemia.


Instruction: Dyslipidemia dyslipidemia/exp OR 'hypercholesterolemia'?

Output: hyperlipidaemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Dyslipidemia dyslipidemia/exp OR 'hypercholesterolemia'?. ### Response: hyperlipidaemia.