Instruction: What is dynamic and risk should be re-assessed at everypatient contact?

Output: Stroke risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is dynamic and risk should be re-assessed at everypatient contact?. ### Response: Stroke risk.


Instruction: What was the best predictor for ischemic stroke?

Output: delta CHA 2DS2VASc score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the best predictor for ischemic stroke?. ### Response: delta CHA 2DS2VASc score.


Instruction: What is the stepwise approach to thromboprophylaxis called?

Output: Step 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the stepwise approach to thromboprophylaxis called?. ### Response: Step 1.


Instruction: What is Step 2?

Output: stroke prevention can beoffered to all others

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Step 2?. ### Response: stroke prevention can beoffered to all others.


Instruction: What does Step 2 use to aid decision-making?

Output: stroke riskscores

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Step 2 use to aid decision-making?. ### Response: stroke riskscores.


Instruction: How should stroke risk be assessed?

Output: at everypatient contact

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How should stroke risk be assessed?. ### Response: at everypatient contact.


Instruction: What should stroke risk be assessed using instead of ancategorization into low, moderate/high risk strata?

Output: arisk factor based approach

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should stroke risk be assessed using instead of ancategorization into low, moderate/high risk strata?. ### Response: arisk factor based approach.


Instruction: What should be used as a simpleclinical based stroke risk score?

Output: CHA2DS2-VASc

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be used as a simpleclinical based stroke risk score?. ### Response: CHA2DS2-VASc.


Instruction: Who should not be offeredantithrombotic therapy to prevent stroke and reducemortality?

Output: lowstroke risk ’patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should not be offeredantithrombotic therapy to prevent stroke and reducemortality?. ### Response: lowstroke risk ’patients.


Instruction: Low risk patients are generally those age 65 and what?

Output: <65

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Low risk patients are generally those age 65 and what?. ### Response: <65.


Instruction: What should be offered to AF patients with one or more non-sex CHA 2DS2-VASc stroke riskfactors?

Output: strokeprevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be offered to AF patients with one or more non-sex CHA 2DS2-VASc stroke riskfactors?. ### Response: strokeprevention.


Instruction: What should score of 1 in males or 2 in females be?

Output: ¼0

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should score of 1 in males or 2 in females be?. ### Response: ¼0.


Instruction: 2 in a female)(Strong recommendation, moderate quality evidence).

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: 2 in a female)(Strong recommendation, moderate quality evidence).. ### Response: ‡.


Instruction: Imaging (cardiac or cerebral), orbiomarkers (urine, blood, or genetics) may re fine riskchestjournal.org 1145

Output: ﬁ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Imaging (cardiac or cerebral), orbiomarkers (urine, blood, or genetics) may re fine riskchestjournal.org 1145. ### Response: ﬁ.


Instruction: What is enalapril therapy used for in patients with left ventricular dysfunction?

Output: cardiac structure and function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is enalapril therapy used for in patients with left ventricular dysfunction?. ### Response: cardiac structure and function.


Instruction: What are the results of the SOLVD echocardiography substudy?

Output: Effects of long-term enalapril therapy on cardiac structure and function in patients with left ventricular dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of the SOLVD echocardiography substudy?. ### Response: Effects of long-term enalapril therapy on cardiac structure and function in patients with left ventricular dysfunction.


Instruction: What does inhibition of angiotensin-converting enzyme do?

Output: Improvement of myocardial blood flow to ischemic regions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does inhibition of angiotensin-converting enzyme do?. ### Response: Improvement of myocardial blood flow to ischemic regions.


Instruction: What protects human myocardium during percutaneous coronary angioplasty?

Output: Pretreatment with intracoronary enalaprilat

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What protects human myocardium during percutaneous coronary angioplasty?. ### Response: Pretreatment with intracoronary enalaprilat.


Instruction: What stimulates the release of tissue plasminogen ac-tivator in human coronary circulation: effects of angiotensin-converting enzyme inhibitors?

Output: Bradykinin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What stimulates the release of tissue plasminogen ac-tivator in human coronary circulation: effects of angiotensin-converting enzyme inhibitors?. ### Response: Bradykinin.


Instruction: What is the effect of angiotensin-converting enzyme inhibitors after acute myocardial infarction?

Output: Improvement of myocardial blood flow to ischemic regions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of angiotensin-converting enzyme inhibitors after acute myocardial infarction?. ### Response: Improvement of myocardial blood flow to ischemic regions.


Instruction: What is ahajournals.org about?

Output: http://ahajournals.org by on May 3, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ahajournals.org about?. ### Response: http://ahajournals.org by on May 3, 2023.


Instruction: What is the 1-year recurrence risk?

Output: 4% per year to 11% per year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 1-year recurrence risk?. ### Response: 4% per year to 11% per year.


Instruction: What is a leading cause of vascular dementia and vascular cognitive impairment?

Output: small vessel disease and lacunar strokes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a leading cause of vascular dementia and vascular cognitive impairment?. ### Response: small vessel disease and lacunar strokes.


Instruction: What has been assessed by prior investigative studies on stroke recurrence after stroke related to small vessel disease?

Output: the impact of BP control and antiplatelet therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been assessed by prior investigative studies on stroke recurrence after stroke related to small vessel disease?. ### Response: the impact of BP control and antiplatelet therapy.


Instruction: What have these studies supported?

Output: general guidance for the use of antiplatelet therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have these studies supported?. ### Response: general guidance for the use of antiplatelet therapy.


Instruction: What is needed to develop and test disease-specific treatments for secondary stroke prevention after small vessel stroke?

Output: More research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed to develop and test disease-specific treatments for secondary stroke prevention after small vessel stroke?. ### Response: More research.


Instruction: What is the focus of this report?

Output: clinical ischemic stroke related to small vessel disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the focus of this report?. ### Response: clinical ischemic stroke related to small vessel disease.


Instruction: When was silent small vessel disease reviewed?

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was silent small vessel disease reviewed?. ### Response: 2017.


Instruction: What was silent small vessel disease reviewed in a 2017 scientific statement?

Output: clinical ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was silent small vessel disease reviewed in a 2017 scientific statement?. ### Response: clinical ischemic stroke.


Instruction: Cilostazol has been studied as an alternative to what?

Output: aspirin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cilostazol has been studied as an alternative to what?. ### Response: aspirin therapy.


Instruction: What was compared with placebo in 1095 Japanese?

Output: cilostazol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was compared with placebo in 1095 Japanese?. ### Response: cilostazol.


Instruction: What was cilostazol compared with in 1095 Japanese patients with noncardioembolic ischemic stroke?

Output: placebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was cilostazol compared with in 1095 Japanese patients with noncardioembolic ischemic stroke?. ### Response: placebo.


Instruction: What was the percentage of small vessel stroke in Japanese patients?

Output: 64%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the percentage of small vessel stroke in Japanese patients?. ### Response: 64%.


Instruction: Cilostazol was compared to aspirin in what subgroup?

Output: analy-sis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cilostazol was compared to aspirin in what subgroup?. ### Response: analy-sis.


Instruction: What was compared with aspirin for the prevention of ischemic stroke?

Output: Cilostazol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was compared with aspirin for the prevention of ischemic stroke?. ### Response: Cilostazol.


Instruction: How many Japanese participants participated in the CSPS II trial?

Output: 2575

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many Japanese participants participated in the CSPS II trial?. ### Response: 2575.


Instruction: What percentage of Japanese participants had small vessel stroke as the qualifying event?

Output: 64%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of Japanese participants had small vessel stroke as the qualifying event?. ### Response: 64%.


Instruction: What was the risk of first occurrence of ischemic or hemorrhagic stroke in the cilostazol group compared with the aspirin group?

Output: reduced

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk of first occurrence of ischemic or hemorrhagic stroke in the cilostazol group compared with the aspirin group?. ### Response: reduced.


Instruction: There were significantly fewer hemorragic events in what group of people?

Output: cilostazol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There were significantly fewer hemorragic events in what group of people?. ### Response: cilostazol.


Instruction: What subgroup of people with small vessel stroke had a nonsignificant reduction in recurrent stroke risk?

Output: cilostazol group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What subgroup of people with small vessel stroke had a nonsignificant reduction in recurrent stroke risk?. ### Response: cilostazol group.


Instruction: What was the risk in participants with small vessel stroke in the subgroup analysis?

Output: nonsignificant reduction in recurrent stroke risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk in participants with small vessel stroke in the subgroup analysis?. ### Response: nonsignificant reduction in recurrent stroke risk.


Instruction: What were the reported side effects in the cilostazol group?

Output: headache, dizziness, palpitations, diarrhea, tachycardia, and constipation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the reported side effects in the cilostazol group?. ### Response: headache, dizziness, palpitations, diarrhea, tachycardia, and constipation.


Instruction: What may limit generalizability?

Output: the inclusion of a single ethnic group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may limit generalizability?. ### Response: the inclusion of a single ethnic group.


Instruction: What is the role of cilostazol in secondary prevention after stroke related to small vessel disease?

Output: an alternative to aspirin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of cilostazol in secondary prevention after stroke related to small vessel disease?. ### Response: an alternative to aspirin therapy.


Instruction: What is a metabolic syndrome?

Output: abdominal obesity, hy -pertension, diabetes, and dyslipidemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a metabolic syndrome?. ### Response: abdominal obesity, hy -pertension, diabetes, and dyslipidemia.


Instruction: What are some metabolic syndromes?

Output: abdominal obesity, hy -pertension, diabetes, and dyslipidemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some metabolic syndromes?. ### Response: abdominal obesity, hy -pertension, diabetes, and dyslipidemia.


Instruction: How did SPRINT define patients with increased cardiovascular risk?

Output: thosemeeting at least 1 of the following criteria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did SPRINT define patients with increased cardiovascular risk?. ### Response: thosemeeting at least 1 of the following criteria.


Instruction: What is another type of cardiovascular disease?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another type of cardiovascular disease?. ### Response: stroke.


Instruction: What is the risk for cardiovascular disease based on the Framingham riskscore?

Output: reduction in the primary composite outcomeof nonfatal myocardial infarction, nonfatal stroke, or death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk for cardiovascular disease based on the Framingham riskscore?. ### Response: reduction in the primary composite outcomeof nonfatal myocardial infarction, nonfatal stroke, or death.


Instruction: How old is this trial?

Output: 60 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old is this trial?. ### Response: 60 years.


Instruction: How old is the risk score?

Output: 75 years or older

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old is the risk score?. ### Response: 75 years or older.


Instruction: What was the baseline SBP of adults with diabetes or prior stroke?

Output: less than140 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the baseline SBP of adults with diabetes or prior stroke?. ### Response: less than140 mm Hg.


Instruction: How did the trial find that targetingSBP to less than 120 mm Hg significantly reduced fatal and nonfatal strokes?

Output: there were more serious adverse events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did the trial find that targetingSBP to less than 120 mm Hg significantly reduced fatal and nonfatal strokes?. ### Response: there were more serious adverse events.


Instruction: What was the RR of ACCORD?

Output: 40

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the RR of ACCORD?. ### Response: 40.


Instruction: What was RR, CI, 0.80 to?

Output: 1.11

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was RR, CI, 0.80 to?. ### Response: 1.11.


Instruction: What is the RR of stroke?

Output: 0.58

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the RR of stroke?. ### Response: 0.58.


Instruction: What was the CI of stroke to death from cardiovascular events?

Output: 0.80 to 1.11

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the CI of stroke to death from cardiovascular events?. ### Response: 0.80 to 1.11.


Instruction: The study found a reduction in what?

Output: stroke events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The study found a reduction in what?. ### Response: stroke events.


Instruction: What should be added to the end of the sentence under the heading "High Value Care" on page 435?

Output: insome patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be added to the end of the sentence under the heading "High Value Care" on page 435?. ### Response: insome patients.


Instruction: What is most benefit achieved by aimingfor lower BP targets?

Output: acceptableharms and costs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is most benefit achieved by aimingfor lower BP targets?. ### Response: acceptableharms and costs.


Instruction: What does the pharmacologic treatment of patients with an SBP of 150 mm Hg or greater have?

Output: acceptableharms and costs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the pharmacologic treatment of patients with an SBP of 150 mm Hg or greater have?. ### Response: acceptableharms and costs.


Instruction: What is the name of the committee responsible for the clinical guidelines of the American College of Physicians and the Commissionon Health of the Public and Science?

Output: ClinicalGuide-lines Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the committee responsible for the clinical guidelines of the American College of Physicians and the Commissionon Health of the Public and Science?. ### Response: ClinicalGuide-lines Committee.


Instruction: What is a clinical practice guideline from the American College of Physicians and the American Academy ofFamily Physicians?

Output: Pharmacologic treatment of hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a clinical practice guideline from the American College of Physicians and the American Academy ofFamily Physicians?. ### Response: Pharmacologic treatment of hypertension.


Instruction: How old are adults with hypertension?

Output: 60 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old are adults with hypertension?. ### Response: 60 years.


Instruction: What year did Ann Intern Med publish?

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Ann Intern Med publish?. ### Response: 2017.


Instruction: What is the name of the systematic review and meta-analysis of benefits and harms of intensive blood pressure treatment in adults aged 60 years or older?

Output: beneﬁts andharms of intensive blood pressure treatment in adults aged 60 years or older:a systematic review and meta-analysis. Ann Intern Med. 2017;166:419-429

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta-analysis of benefits and harms of intensive blood pressure treatment in adults aged 60 years or older?. ### Response: beneﬁts andharms of intensive blood pressure treatment in adults aged 60 years or older:a systematic review and meta-analysis. Ann Intern Med. 2017;166:419-429.


Instruction: What year did Ann Intern Med issue 166:419-429?

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Ann Intern Med issue 166:419-429?. ### Response: 2017.


Instruction: When was Annals of Internal Medicine Vol. 166 No. 6 published?

Output: 21 March 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Annals of Internal Medicine Vol. 166 No. 6 published?. ### Response: 21 March 2017.


Instruction: Who was the author of the book?

Output: Sarath Ss

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the author of the book?. ### Response: Sarath Ss.


Instruction: When did Sarath Ss upload the book to her website?

Output: 05/03/2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Sarath Ss upload the book to her website?. ### Response: 05/03/2023.


Instruction: What is NICE 2018?

Output: Chronic Heart Failure  Monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE 2018?. ### Response: Chronic Heart Failure  Monitoring.


Instruction: What is the ISBN number of 978-1-4731 -3093 -7 258?

Output: Chronic Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ISBN number of 978-1-4731 -3093 -7 258?. ### Response: Chronic Heart Failure.


Instruction: Low quality evidence suggested no clinical effect of what?

Output: NP monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Low quality evidence suggested no clinical effect of what?. ### Response: NP monitoring.


Instruction: Mortality did not demons trate a clear effect with the confidence interval ranging from a decrease and increase in all-cause mortality?

Output: demonstrate a clear effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Mortality did not demons trate a clear effect with the confidence interval ranging from a decrease and increase in all-cause mortality?. ### Response: demonstrate a clear effect.


Instruction: What was found for the outcome mortality (n=182)?

Output: High quality evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was found for the outcome mortality (n=182)?. ### Response: High quality evidence.


Instruction: What did the evidence suggest for HF hospitalisations?

Output: a clinically important reduction with NP monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the evidence suggest for HF hospitalisations?. ### Response: a clinically important reduction with NP monitoring.


Instruction: How old was the sample?

Output: <75 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old was the sample?. ### Response: <75 years.


Instruction: What was found for the outcome mortality reported as a hazard ratio?

Output: Moderate to very low quality evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was found for the outcome mortality reported as a hazard ratio?. ### Response: Moderate to very low quality evidence.


Instruction: What did the low quality evidence suggest for the reduction in the number of deaths with NP monitoring suggest?

Output: no clinical effect of NP monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the low quality evidence suggest for the reduction in the number of deaths with NP monitoring suggest?. ### Response: no clinical effect of NP monitoring.


Instruction: How many deaths were there with NP monitoring?

Output: n=289

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many deaths were there with NP monitoring?. ### Response: n=289.


Instruction: What was found to be low quality evidence for the outcomes all-cause hospitalisation and HF hospitalisation?

Output: n=50

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was found to be low quality evidence for the outcomes all-cause hospitalisation and HF hospitalisation?. ### Response: n=50.


Instruction: How old was the evidence for the outcomes mortality reported as a hazard ratio?

Output: <75 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old was the evidence for the outcomes mortality reported as a hazard ratio?. ### Response: <75 years.


Instruction: What was the risk ratio reported as?

Output: n=121

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk ratio reported as?. ### Response: n=121.


Instruction: What was the risk ratio?

Output: n=121

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk ratio?. ### Response: n=121.


Instruction: What did not show a clear effect with the confidence interval ranging from a decrease and increase in a ll-cause mortality?

Output: Mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did not show a clear effect with the confidence interval ranging from a decrease and increase in a ll-cause mortality?. ### Response: Mortality.


Instruction: How many hospitalisations suggested a clinically important increase with NP monitoring?

Output: n=121

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many hospitalisations suggested a clinically important increase with NP monitoring?. ### Response: n=121.


Instruction: No relevant studies were identified comparing usual care with troponin or combinations of what?

Output: different bi omarkers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No relevant studies were identified comparing usual care with troponin or combinations of what?. ### Response: different bi omarkers.


Instruction: What was the cost effective compa red to specialist clinical assessment in CHF and LVSD patients?

Output: specialist natriuretic peptide monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the cost effective compa red to specialist clinical assessment in CHF and LVSD patients?. ### Response: specialist natriuretic peptide monitoring.


Instruction: How much did ICER cost per QALY gained?

Output: £3,304

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much did ICER cost per QALY gained?. ### Response: £3,304.


Instruction: What was the ICER per QALY gained for CHF and LVSD specialist natriuretic peptide monitoring?

Output: £3,304

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the ICER per QALY gained for CHF and LVSD specialist natriuretic peptide monitoring?. ### Response: £3,304.


Instruction: What was more cost effective than specialist clinical assessment?

Output: specialist natriuretic peptide monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was more cost effective than specialist clinical assessment?. ### Response: specialist natriuretic peptide monitoring.


Instruction: At what age was specialist natriuretic peptide monitoring cost effective compared to specialist clinical assessment?

Output: 75

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: At what age was specialist natriuretic peptide monitoring cost effective compared to specialist clinical assessment?. ### Response: 75.


Instruction: What was the ICER per QALY gained for CHF and LVSD patients?

Output: £3,304

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the ICER per QALY gained for CHF and LVSD patients?. ### Response: £3,304.


Instruction: How much does ICER cost per QALY gained compared to specialist clinical assessment?

Output: £3,304

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much does ICER cost per QALY gained compared to specialist clinical assessment?. ### Response: £3,304.


Instruction: What is a condition in which t he hear t does not pump enough blood?

Output: Introduc tion Hear t failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a condition in which t he hear t does not pump enough blood?. ### Response: Introduc tion Hear t failure.


Instruction: What is the cause of Introduction Hear t failure?

Output: dysfunction of t he hear t due t o muscle damage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cause of Introduction Hear t failure?. ### Response: dysfunction of t he hear t due t o muscle damage.


Instruction: What is the term for muscle damage?

Output: syst olic or diast olic dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for muscle damage?. ### Response: syst olic or diast olic dysfunction.


Instruction: What is acut e hear t failure in people wit kno wn car diac dysfunction?

Output: diagnosis and management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is acut e hear t failure in people wit kno wn car diac dysfunction?. ### Response: diagnosis and management.


Instruction: What is a common cause of hospital admissions?

Output: Acut e hear t failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a common cause of hospital admissions?. ### Response: Acut e hear t failure.


Instruction: How many admissions in England and W ales per year?

Output: over 67 ,000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many admissions in England and W ales per year?. ### Response: over 67 ,000.


Instruction: What is the leading cause of ear failure?

Output: acute

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the leading cause of ear failure?. ### Response: acute.


Instruction: What is the leading cause of hospital admission in people 65 years or older in the UK?

Output: Acut e hear t failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the leading cause of hospital admission in people 65 years or older in the UK?. ### Response: Acut e hear t failure.


Instruction: The guideline includes impor tant aspects of what?

Output: t he diagnosis and management of acut e hear t failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The guideline includes impor tant aspects of what?. ### Response: t he diagnosis and management of acut e hear t failure.


Instruction: What is the NICE guideline on chr onic hear t failure focusing on?

Output: long

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the NICE guideline on chr onic hear t failure focusing on?. ### Response: long.


Instruction: What does the guideline focuses on long-t erm management rat her than on the immediat e care of someone who is acut ely unw ell?

Output: t han

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the guideline focuses on long-t erm management rat her than on the immediat e care of someone who is acut ely unw ell?. ### Response: t han.


Instruction: What is acut ely unw ell as a r esult of hear t failure?

Output: diagnosis and management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is acut ely unw ell as a r esult of hear t failure?. ### Response: diagnosis and management.


Instruction: How old is the adult who has a diagnosis of acute hearing failure considered to be?

Output: 18  years or older

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old is the adult who has a diagnosis of acute hearing failure considered to be?. ### Response: 18  years or older.


Instruction: What is the role of early natriur etic peptide t esting and echocar diograph?

Output: specialist management unit s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of early natriur etic peptide t esting and echocar diograph?. ### Response: specialist management unit s.


Instruction: Early natriur etic peptide t esting and echocar diography • the role of specialist management units • the use of v entilat ory suppor t, pharmacological t herap y and ultrafiltration • treatment aft er stabilisation, including select ed sur gical int ersventions and initiation of what?

Output: t he following k ey clinical ar eas

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Early natriur etic peptide t esting and echocar diography • the role of specialist management units • the use of v entilat ory suppor t, pharmacological t herap y and ultrafiltration • treatment aft er stabilisation, including select ed sur gical int ersventions and initiation of what?. ### Response: t he following k ey clinical ar eas.


Instruction: What are ed sur gical int erventions and initiation of the pharmacological t herapies t hat ar e used in the management of chronic hear t failure?

Output: treatment aft er stabilisation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are ed sur gical int erventions and initiation of the pharmacological t herapies t hat ar e used in the management of chronic hear t failure?. ### Response: treatment aft er stabilisation.


Instruction: What will assume pr escribers will use a drug's summar y of pr oduct charact eristics?

Output: The guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will assume pr escribers will use a drug's summar y of pr oduct charact eristics?. ### Response: The guideline.


Instruction: What does a drug's summar y of pr oduct charact eristics help inform?

Output: decisions made wit h individual patient s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does a drug's summar y of pr oduct charact eristics help inform?. ### Response: decisions made wit h individual patient s.


Instruction: What is the title of the book Acut e hear t failure: diagnosis and management?

Output: CG187

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of the book Acut e hear t failure: diagnosis and management?. ### Response: CG187.


Instruction: What is the last updat ed 17 No vember 2021?

Output: Page 5of 18

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the last updat ed 17 No vember 2021?. ### Response: Page 5of 18.


Instruction: Where did Charles R.V. Tomson receive his un-dergraduate training?

Output: Cambridgeand Oxford, UK

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where did Charles R.V. Tomson receive his un-dergraduate training?. ### Response: Cambridgeand Oxford, UK.


Instruction: How many book chapters has Charles Tomson authored or coauthored?

Output: 36

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many book chapters has Charles Tomson authored or coauthored?. ### Response: 36.


Instruction: How many book chapters has Tyne authored or coauthored?

Output: third

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many book chapters has Tyne authored or coauthored?. ### Response: third.


Instruction: How many journal articles has he coauthored or authored on topics such as hypertension, CKD, and cardiovascular complications of kid-ney disease?

Output: 250

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many journal articles has he coauthored or authored on topics such as hypertension, CKD, and cardiovascular complications of kid-ney disease?. ### Response: 250.


Instruction: What was the name of the third edition of the Renal Association Clinical Practice Guidelines?

Output: Charles R.V. Tomson, MA, BM,Bch, DM, FRCP, received his un-dergraduate training at Cambridgeand Oxford, UK, and underwentclinical training in Nottingham,Newcastle upon Tyne, andLeicester, UK, before taking upconsultant posts at St Barts, Lon-don (1991 –1993), Bristol (1993 –2014), and Newcastle upon Tyne(2014 –2018). He has authored or coauthored 36 book chaptersand over 250 journal articles on a wide range of topics includinghypertension, CKD, and cardiovascular complications of kid-ney disease. His involvement in guideline development startedwith the third edition of the Renal Association Clinical PracticeGuidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the third edition of the Renal Association Clinical Practice Guidelines?. ### Response: Charles R.V. Tomson, MA, BM,Bch, DM, FRCP, received his un-dergraduate training at Cambridgeand Oxford, UK, and underwentclinical training in Nottingham,Newcastle upon Tyne, andLeicester, UK, before taking upconsultant posts at St Barts, Lon-don (1991 –1993), Bristol (1993 –2014), and Newcastle upon Tyne(2014 –2018). He has authored or coauthored 36 book chaptersand over 250 journal articles on a wide range of topics includinghypertension, CKD, and cardiovascular complications of kid-ney disease. His involvement in guideline development startedwith the third edition of the Renal Association Clinical PracticeGuidelines.


Instruction: Who produced the 2012 Management of Blood Pressure in CKD guideline?

Output: Renal Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who produced the 2012 Management of Blood Pressure in CKD guideline?. ### Response: Renal Association.


Instruction: Who was a Health Foundation Quality Improvement Fellow?

Output: Charles R.V. Tomson

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was a Health Foundation Quality Improvement Fellow?. ### Response: Charles R.V. Tomson.


Instruction: Where was the Institute for Healthcare Improvement located?

Output: Boston

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where was the Institute for Healthcare Improvement located?. ### Response: Boston.


Instruction: Who was the Chair of the UK Renal Registry from 2006 to 2010?

Output: Charles R.V. Tomson

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the Chair of the UK Renal Registry from 2006 to 2010?. ### Response: Charles R.V. Tomson.


Instruction: What was the president of the Renal Association from 2010 to 2012?

Output: Michel Jadoul

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the president of the Renal Association from 2010 to 2012?. ### Response: Michel Jadoul.


Instruction: Who is a trustee of Kidney Research UK?

Output: Michel Jadoul

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a trustee of Kidney Research UK?. ### Response: Michel Jadoul.


Instruction: In what year did Michel Jadoul retire from clinical practice?

Output: 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did Michel Jadoul retire from clinical practice?. ### Response: 2018.


Instruction: What was the name of the pandemic that led to Michel's retirement?

Output: COVID-19

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the pandemic that led to Michel's retirement?. ### Response: COVID-19.


Instruction: Where did Michel receive his medi-cal degree in 1983?

Output: UniversitéCatholique de Louvain

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where did Michel receive his medi-cal degree in 1983?. ### Response: UniversitéCatholique de Louvain.


Instruction: In what country is the UCLouvain located?

Output: Belgium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what country is the UCLouvain located?. ### Response: Belgium.


Instruction: Where was Dr. Jadoul trained in 1983?

Output: UniversitéCatholique de Louvain

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where was Dr. Jadoul trained in 1983?. ### Response: UniversitéCatholique de Louvain.


Instruction: Where is the UniversitéCatholique de Louvain located?

Output: Brussels, Belgium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the UniversitéCatholique de Louvain located?. ### Response: Brussels, Belgium.


Instruction: Who mentored Dr.Jadoul in internal medicine and nephrology?

Output: Professor Charles vanYpersele de Strihou

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who mentored Dr.Jadoul in internal medicine and nephrology?. ### Response: Professor Charles vanYpersele de Strihou.


Instruction: Who is currently a full clinicalprofessor at UCLouvain?

Output: Dr. Jadoul

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is currently a full clinicalprofessor at UCLouvain?. ### Response: Dr. Jadoul.


Instruction: Dr. Jadoul’s clinical activities focus on the follow-up of what patients?

Output: hemodialysis and CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Dr. Jadoul’s clinical activities focus on the follow-up of what patients?. ### Response: hemodialysis and CKD.


Instruction: How many scientific papers has Dr. Jadoul coauthored?

Output: over 260

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many scientific papers has Dr. Jadoul coauthored?. ### Response: over 260.


Instruction: What is the name of the organization that Dr.Jadoul is a member of?

Output: Cliniques Universitaires Saint-Luc

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that Dr.Jadoul is a member of?. ### Response: Cliniques Universitaires Saint-Luc.


Instruction: What is the name of the book that treats heart failure chronic heart failure?

Output: NICE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the book that treats heart failure chronic heart failure?. ### Response: NICE.


Instruction: Who is the author of NICE 2018?

Output: 978 -1-4731 -3093 -7 190

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of NICE 2018?. ### Response: 978 -1-4731 -3093 -7 190.


Instruction: What is the CI for the relative effect of ARB?

Output: 95%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the CI for the relative effect of ARB?. ### Response: 95%.


Instruction: What is a risk with placebo risk difference with ARB 95% CI?

Output: Anticipated absolute effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk with placebo risk difference with ARB 95% CI?. ### Response: Anticipated absolute effects.


Instruction: How many events were there in both arms?

Output: zero

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many events were there in both arms?. ### Response: zero.


Instruction: Table 63: ARB high dose versus low dose (CKD class 3a/b) Outcomes

Output: No of Participants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Table 63: ARB high dose versus low dose (CKD class 3a/b) Outcomes. ### Response: No of Participants.


Instruction: What is CKD class 3a/b?

Output: ARB high dose versus low dose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CKD class 3a/b?. ### Response: ARB high dose versus low dose.


Instruction: What is Quality of the evidence?

Output: Relative effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Quality of the evidence?. ### Response: Relative effect.


Instruction: Anticipated absolute effects Risk with low dose Risk difference with ARB high dose 95% CI?

Output: Placebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Anticipated absolute effects Risk with low dose Risk difference with ARB high dose 95% CI?. ### Response: Placebo.


Instruction: What is the risk difference with ARB high dose (95% CI)?

Output: Risk with low dose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk difference with ARB high dose (95% CI)?. ### Response: Risk with low dose.


Instruction: How many studies were conducted?

Output: 945

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were conducted?. ### Response: 945.


Instruction: What was the combined outcome of the study?

Output: death or HF hospitalisation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the combined outcome of the study?. ### Response: death or HF hospitalisation.


Instruction: Why was the risk of bias, indirectness LOW?

Output: due to risk of bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the risk of bias, indirectness LOW?. ### Response: due to risk of bias.


Instruction: How many fewer per 1000 were there?

Output: 6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many fewer per 1000 were there?. ### Response: 6.


Instruction: How many increments were there if the majority of the evidence was at high risk of bias?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many increments were there if the majority of the evidence was at high risk of bias?. ### Response: 2.


Instruction: How many increments were given if the majority of the evidence was at very high risk of bias?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many increments were given if the majority of the evidence was at very high risk of bias?. ### Response: 2.


Instruction: Why was the 1 increment downgraded due to indirectness?

Output: outcome was compound rather than numbers of admissions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the 1 increment downgraded due to indirectness?. ### Response: outcome was compound rather than numbers of admissions.


Instruction: What was the outcome compound rather than numbers of admissions?

Output: death or HF hospitalisation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome compound rather than numbers of admissions?. ### Response: death or HF hospitalisation.


Instruction: What is the term for CKD stages 3-4?

Output: Beta -blocker versus placebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for CKD stages 3-4?. ### Response: Beta -blocker versus placebo.


Instruction: What is another term for Quality of the evidence?

Output: GRADE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for Quality of the evidence?. ### Response: GRADE.


Instruction: What is the 95% CI of all-cause mortality - CKD class 3a 1645?

Output: Risk difference with Beta -blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 95% CI of all-cause mortality - CKD class 3a 1645?. ### Response: Risk difference with Beta -blocker.


Instruction: Why is LOWb due to risk of bias?

Output: indirectness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is LOWb due to risk of bias?. ### Response: indirectness.


Instruction: How many fewer per 1000 is estimated?

Output: 6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many fewer per 1000 is estimated?. ### Response: 6.


Instruction: How many fewer people die from CKD?

Output: 30

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many fewer people die from CKD?. ### Response: 30.


Instruction: How many more deaths are there per 1000?

Output: 820

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many more deaths are there per 1000?. ### Response: 820.


Instruction: What is the all-cause mortality rate?

Output: HR 0.5 5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the all-cause mortality rate?. ### Response: HR 0.5 5.


Instruction: How many MRI slot s per da y are there?

Output: limit s on t he number

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many MRI slot s per da y are there?. ### Response: limit s on t he number.


Instruction: What is a need f or dedicating ed MRI slots for people wit h suspected TiA?

Output: limit s on t he number of MRI slot s per da y

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a need f or dedicating ed MRI slots for people wit h suspected TiA?. ### Response: limit s on t he number of MRI slot s per da y.


Instruction: What is acu te ischaemic stroke?

Output: transient ischaemic attack

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is acu te ischaemic stroke?. ### Response: transient ischaemic attack.


Instruction: Why did the c ommi ttee make the r ecommendations Anterior cir culation str oke?

Output: because t his is out side t he licensed time windo w

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why did the c ommi ttee make the r ecommendations Anterior cir culation str oke?. ### Response: because t his is out side t he licensed time windo w.


Instruction: What is the modified Rankin Scale?

Output: mRS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the modified Rankin Scale?. ### Response: mRS.


Instruction: What are people last kno wn to be w ell up to 24 hours?

Output: modified Rankin Scale

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are people last kno wn to be w ell up to 24 hours?. ### Response: modified Rankin Scale.


Instruction: What was also a pot ential benefit of or impr oved quality of lif e?

Output: Ther e

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was also a pot ential benefit of or impr oved quality of lif e?. ### Response: Ther e.


Instruction: There was no clinical diff erence in mor tality and low rat es of what?

Output: sympt omatic intracer ebral haemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There was no clinical diff erence in mor tality and low rat es of what?. ### Response: sympt omatic intracer ebral haemorrhage.


Instruction: Low rat es of sympt omatic intracer ebral haemorrhage?

Output: there was no clinical diff erence in mor tality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Low rat es of sympt omatic intracer ebral haemorrhage?. ### Response: there was no clinical diff erence in mor tality.


Instruction: Did there have been some pr ocedural complications associat ed with h thrombectomy?

Output: there was no clinical diff erence in mor tality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Did there have been some pr ocedural complications associat ed with h thrombectomy?. ### Response: there was no clinical diff erence in mor tality.


Instruction: How many published cost-utility analyses were wit h a UK NHS perspectiv e?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many published cost-utility analyses were wit h a UK NHS perspectiv e?. ### Response: 2.


Instruction: What was the first estimat ed that t hrombect omy alongside intravenous thrombolysis?

Output: cost eff ectiv e

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the first estimat ed that t hrombect omy alongside intravenous thrombolysis?. ### Response: cost eff ectiv e.


Instruction: What is omy along with intra venous t hrombolysis?

Output: t hrombect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is omy along with intra venous t hrombolysis?. ### Response: t hrombect.


Instruction: How many hours of str oke onset is performed?

Output: 6  hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many hours of str oke onset is performed?. ### Response: 6  hours.


Instruction: When a person was last kno wn to be w ell?

Output: 13 April 2022

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When a person was last kno wn to be w ell?. ### Response: 13 April 2022.


Instruction: The second demonstrat ed the cost eff ectiv eness of what?

Output: t hrombect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The second demonstrat ed the cost eff ectiv eness of what?. ### Response: t hrombect.


Instruction: When per formed 6 to 24 hours, how long did it take to compare wit h best medical t herap y alone?

Output: 2 4 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When per formed 6 to 24 hours, how long did it take to compare wit h best medical t herap y alone?. ### Response: 2 4 hours.


Instruction: How long aft er str oke onset is thrombect omy up to?

Output: 24 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long aft er str oke onset is thrombect omy up to?. ### Response: 24 hours.


Instruction: How long is thrombolysis within the licensed time frame?

Output: 6  and 2 4 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is thrombolysis within the licensed time frame?. ### Response: 6  and 2 4 hours.


Instruction: What if within the licensed time windo w, for people wit h appr opriat e clinical and radiological charact eristics?

Output: her wit h intra venous t hrombolysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What if within the licensed time windo w, for people wit h appr opriat e clinical and radiological charact eristics?. ### Response: her wit h intra venous t hrombolysis.


Instruction: How long do people pr esenting betw een 6 and 2 4 hours aft er str oke onset receiv ed thrombolysis?

Output: F ew people pr esenting betw een 6  and 2 4 hours aft er str oke onset receiv ed thrombolysis because t his is out side t he licensed time windo w

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long do people pr esenting betw een 6 and 2 4 hours aft er str oke onset receiv ed thrombolysis?. ### Response: F ew people pr esenting betw een 6  and 2 4 hours aft er str oke onset receiv ed thrombolysis because t his is out side t he licensed time windo w.


Instruction: Why is str oke onset receiv ed thrombolysis out side t he licensed time windo w?

Output: because t his

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is str oke onset receiv ed thrombolysis out side t he licensed time windo w?. ### Response: because t his.


Instruction: What is the recommendation f or those pr senting be yond 6 hours?

Output: f or thrombect omy alone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommendation f or those pr senting be yond 6 hours?. ### Response: f or thrombect omy alone.


Instruction: How many hours of onset was fr om populations Stroke and transient ischaemic attack in o ver 16s: diagnosis and initial management(NG128)?

Output: 6  hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many hours of onset was fr om populations Stroke and transient ischaemic attack in o ver 16s: diagnosis and initial management(NG128)?. ### Response: 6  hours.


Instruction: What does Notice of right s stand for?

Output: All right s reserved

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Notice of right s stand for?. ### Response: All right s reserved.


Instruction: What is the last updat ed 13 April 2022?

Output: Page 33of 48

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the last updat ed 13 April 2022?. ### Response: Page 33of 48.


Instruction: How many studies reported the effect of supplemental education interventions on mortality154?

Output: One

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies reported the effect of supplemental education interventions on mortality154?. ### Response: One.


Instruction: How many study each reported thromboembolic154,155,158and bleeding33,154,158outcomes?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many study each reported thromboembolic154,155,158and bleeding33,154,158outcomes?. ### Response: 3.


Instruction: What did three studies assess the impact ofsupplemental education intervention on TTR for patients receiving VKAtherapy?

Output: found no difference

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did three studies assess the impact ofsupplemental education intervention on TTR for patients receiving VKAtherapy?. ### Response: found no difference.


Instruction: Five studies reported change in various knowledgeassessment scores following the educational intervention.

Output: 33,153-159

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Five studies reported change in various knowledgeassessment scores following the educational intervention.. ### Response: 33,153-159.


Instruction: Where is the EtD framework shown online?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the EtD framework shown online?. ### Response: https://dbep.gradepro.org.


Instruction: What does EtDframework reference at the end of this section?

Output: evidence profile

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does EtDframework reference at the end of this section?. ### Response: evidence profile.


Instruction: How many fewer to 305 more people are affected by DVT per 1000?

Output: 25

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many fewer to 305 more people are affected by DVT per 1000?. ### Response: 25.


Instruction: What is the RR of PE?

Output: 0.57

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the RR of PE?. ### Response: 0.57.


Instruction: How many more to 25 more people have DVT?

Output: 22

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many more to 25 more people have DVT?. ### Response: 22.


Instruction: PE is the effect of what?

Output: imprecise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: PE is the effect of what?. ### Response: imprecise.


Instruction: What is the CI for largebenefits and great harm?

Output: CIs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the CI for largebenefits and great harm?. ### Response: CIs.


Instruction: What was the difference between receiving supplemental education and control groups?

Output: no

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the difference between receiving supplemental education and control groups?. ### Response: no.


Instruction: What was effective in improving patient perfor-mance on various knowledge assessments?

Output: Supplemental education

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was effective in improving patient perfor-mance on various knowledge assessments?. ### Response: Supplemental education.


Instruction: What might reduce the risk of bleeding in patients at average risk?

Output: supplemental education

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What might reduce the risk of bleeding in patients at average risk?. ### Response: supplemental education.


Instruction: What is the risk of bleeding in patients that were at average risk for bleeding compared with control patients?

Output: reduce

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of bleeding in patients that were at average risk for bleeding compared with control patients?. ### Response: reduce.


Instruction: How many fewer per 1000 is the ARR?

Output: 8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many fewer per 1000 is the ARR?. ### Response: 8.


Instruction: What are the CIs include largebenefit and great harm?

Output: the effect estimate is very imprecise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the CIs include largebenefit and great harm?. ### Response: the effect estimate is very imprecise.


Instruction: How long were some interventions?

Output: 5-minutevideo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long were some interventions?. ### Response: 5-minutevideo.


Instruction: How long was one-on-oneteaching?

Output: 20 to 30 minutes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was one-on-oneteaching?. ### Response: 20 to 30 minutes.


Instruction: What were the CIs?

Output: largebenefit and great harm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the CIs?. ### Response: largebenefit and great harm.


Instruction: How many minutes of one-on-oneteaching were involved?

Output: 20 to 30

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many minutes of one-on-oneteaching were involved?. ### Response: 20 to 30.


Instruction: Why was there no available study on the cost-effectiveness of supplemental education?

Output: effect estimates are extremely imprecise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was there no available study on the cost-effectiveness of supplemental education?. ### Response: effect estimates are extremely imprecise.


Instruction: Thepanel agreed that individual patients will have different experiences when what is delivered?

Output: supplemental education

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Thepanel agreed that individual patients will have different experiences when what is delivered?. ### Response: supplemental education.


Instruction: What may be different between patients receiving DOACs and those receiving VKA?

Output: patients onDOACs may not receive the same level of follow-up or may be lesslikely to receive care in specialized AMSs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be different between patients receiving DOACs and those receiving VKA?. ### Response: patients onDOACs may not receive the same level of follow-up or may be lesslikely to receive care in specialized AMSs.


Instruction: What may patients onDOACs not receive the same level of follow-up or may be less likely to receive care in specialized AMSs?

Output: differences between patientsreceiving DOACs and those receiving VKA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may patients onDOACs not receive the same level of follow-up or may be less likely to receive care in specialized AMSs?. ### Response: differences between patientsreceiving DOACs and those receiving VKA.


Instruction: What type of education might increase health careequity if it is uniformly administered in a consistent way?

Output: supplemental education

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of education might increase health careequity if it is uniformly administered in a consistent way?. ### Response: supplemental education.


Instruction: What is dietary sodium restriction in stage 3-4 CKD?

Output: Moderate dietarysodium restriction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is dietary sodium restriction in stage 3-4 CKD?. ### Response: Moderate dietarysodium restriction.


Instruction: What did Slagman MC, Waanders F, Hemmelder MH, et al. find in lowering proteinuria and blood pressure?

Output: dual blockade

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Slagman MC, Waanders F, Hemmelder MH, et al. find in lowering proteinuria and blood pressure?. ### Response: dual blockade.


Instruction: What is a type 1 diabeticpatient on normal or high salt intake?

Output: Renal functionalresponse to protein loading

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a type 1 diabeticpatient on normal or high salt intake?. ### Response: Renal functionalresponse to protein loading.


Instruction: What is the effect of short-term moderatesodium restriction on renal function?

Output: relative hyper ﬁltration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of short-term moderatesodium restriction on renal function?. ### Response: relative hyper ﬁltration.


Instruction: What does short-term moderatesodium restriction induce in Type I diabetes mellitus?

Output: relative hyper ﬁltration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does short-term moderatesodium restriction induce in Type I diabetes mellitus?. ### Response: relative hyper ﬁltration.


Instruction: What is the name of the journal that studies renal responses to sodium restriction in patients with earlydiabetes?

Output: J Am Soc Nephrol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies renal responses to sodium restriction in patients with earlydiabetes?. ### Response: J Am Soc Nephrol.


Instruction: When was the J Am Soc Nephrol published?

Output: 1997

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Soc Nephrol published?. ### Response: 1997.


Instruction: What does dietary sodium have on blood pressure in IDDM patients with nephropathy?

Output: Effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does dietary sodium have on blood pressure in IDDM patients with nephropathy?. ### Response: Effects.


Instruction: What is an association between insulin resistance and increased responsiveness to sodium intake?

Output: Enhanced responsivenessof blood pressure to sodium intake and to angiotensin II is associatedwith insulin resistance in IDDM patients with microalbuminuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an association between insulin resistance and increased responsiveness to sodium intake?. ### Response: Enhanced responsivenessof blood pressure to sodium intake and to angiotensin II is associatedwith insulin resistance in IDDM patients with microalbuminuria.


Instruction: What is associated with insulin resistance in IDDM patients with microalbuminuria?

Output: Enhanced responsivenessof blood pressure to sodium intake and to angiotensin II

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with insulin resistance in IDDM patients with microalbuminuria?. ### Response: Enhanced responsivenessof blood pressure to sodium intake and to angiotensin II.


Instruction: What is the name of the randomised blind controlled study of sodium restriction and bloodpressure in hypertensive type II diabetics?

Output: Dodson PM, Beevers M, Hallworth R, et al. Sodium restriction and bloodpressure in hypertensive type II diabetics: randomised blind controlledand crossover studies of moderate sodium restriction and sodiumsupplementation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised blind controlled study of sodium restriction and bloodpressure in hypertensive type II diabetics?. ### Response: Dodson PM, Beevers M, Hallworth R, et al. Sodium restriction and bloodpressure in hypertensive type II diabetics: randomised blind controlledand crossover studies of moderate sodium restriction and sodiumsupplementation.


Instruction: What is the difference between sodium restriction and sodiumsupplementation?

Output: moderate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between sodium restriction and sodiumsupplementation?. ### Response: moderate.


Instruction: What is a low-sodium diet potentiates the effects of losartan in type 2 diabetes?

Output: Short-term moderatesodium restriction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a low-sodium diet potentiates the effects of losartan in type 2 diabetes?. ### Response: Short-term moderatesodium restriction.


Instruction: What is sensitivity related toalbuminuria appearing before hypertension in type 2 diabetic patients?

Output: Sodium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is sensitivity related toalbuminuria appearing before hypertension in type 2 diabetic patients?. ### Response: Sodium.


Instruction: What does dietary sodium restriction impair in noninsulin-dependent diabetes mellitus?

Output: insulin sensitivity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does dietary sodium restriction impair in noninsulin-dependent diabetes mellitus?. ### Response: insulin sensitivity.


Instruction: What is the role of insulin resistance in Type 2 diabetic patients?

Output: Effect of sodium intake

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of insulin resistance in Type 2 diabetic patients?. ### Response: Effect of sodium intake.


Instruction: What does sodium intake have on blood pressure and albuminuria?

Output: insulin resistance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does sodium intake have on blood pressure and albuminuria?. ### Response: insulin resistance.


Instruction: When was the journal Diabetologia published?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the journal Diabetologia published?. ### Response: 2002.


Instruction: How is the effect of angiotensin receptor blockers assessed?

Output: Moderation ofdietary sodium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the effect of angiotensin receptor blockers assessed?. ### Response: Moderation ofdietary sodium.


Instruction: What is the World Health Organization's guideline for Sodium Intake for Adults?

Output: Sodium Intake for Adults andChildren

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the World Health Organization's guideline for Sodium Intake for Adults?. ### Response: Sodium Intake for Adults andChildren.


Instruction: What is the name of the World Health Organization's guideline for Sodium Intake for Adults and Children?

Output: Guideline: Sodium Intake for Adults andChildren

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the World Health Organization's guideline for Sodium Intake for Adults and Children?. ### Response: Guideline: Sodium Intake for Adults andChildren.


Instruction: When was the guideline available?

Output: January 15, 2021

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the guideline available?. ### Response: January 15, 2021.


Instruction: What was the EFSA Panel on Nutrition's report on Novel Foods?

Output: Turck

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the EFSA Panel on Nutrition's report on Novel Foods?. ### Response: Turck.


Instruction: What did Olsson P, Lagergren H, Ek S do to eliminate intravenous heparin from plasma?

Output: elimination

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Olsson P, Lagergren H, Ek S do to eliminate intravenous heparin from plasma?. ### Response: elimination.


Instruction: What was the name of the experimental study done on dogs and humans?

Output: Acta Med Scand

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the experimental study done on dogs and humans?. ### Response: Acta Med Scand.


Instruction: What year was Scand published?

Output: 1963

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was Scand published?. ### Response: 1963.


Instruction: How many pages were in Scand in 1963?

Output: 173 : 619 - 630

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many pages were in Scand in 1963?. ### Response: 173 : 619 - 630.


Instruction: What is the name of the journal that published Scand?

Output: Acta Med Scand

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that published Scand?. ### Response: Acta Med Scand.


Instruction: What is heparin sulphamidase?

Output: activity from rat spleen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is heparin sulphamidase?. ### Response: activity from rat spleen.


Instruction: What is Friedman Y, Arsenis C?

Output: heparin sulphamidase activity from rat spleen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Friedman Y, Arsenis C?. ### Response: heparin sulphamidase activity from rat spleen.


Instruction: In what year was Thromb Res published?

Output: 1979

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was Thromb Res published?. ### Response: 1979.


Instruction: Studies on the heparin sulphamidase activity from rat spleen?

Output: Intracellular distribution and charac-terization of the enzyme

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Studies on the heparin sulphamidase activity from rat spleen?. ### Response: Intracellular distribution and charac-terization of the enzyme.


Instruction: Intracellular distribution and charac-terization of what enzyme?

Output: heparin sulphamidase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Intracellular distribution and charac-terization of what enzyme?. ### Response: heparin sulphamidase.


Instruction: What is the name of the drug used to treat low-dose heparin in man?

Output: Thromb Res

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used to treat low-dose heparin in man?. ### Response: Thromb Res.


Instruction: How many times did Thromb Res issue 14 in 1979?

Output: 6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many times did Thromb Res issue 14 in 1979?. ### Response: 6.


Instruction: What was McAllister's name?

Output: BM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was McAllister's name?. ### Response: BM.


Instruction: McAllister BM, Demis DJ. Heparin metabolism: isolation and characterization of uroheparin. Nature. 1966 ; 212 ( 5059 ): 293 - 294

Output: Nature

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: McAllister BM, Demis DJ. Heparin metabolism: isolation and characterization of uroheparin. Nature. 1966 ; 212 ( 5059 ): 293 - 294. ### Response: Nature.


Instruction: What is the weight-based heparin dosing nomogram compared with?

Output: standard care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the weight-based heparin dosing nomogram compared with?. ### Response: standard care.


Instruction: What is the difference between a weight-based heparin dosing nomogram and a standard care nomogram?

Output: The weight-based heparin dosing nomogram compared with a “standard care” nomogram

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between a weight-based heparin dosing nomogram and a standard care nomogram?. ### Response: The weight-based heparin dosing nomogram compared with a “standard care” nomogram.


Instruction: What is a randomized controlled trial?

Output: The weight-based heparin dosing nomogram

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a randomized controlled trial?. ### Response: The weight-based heparin dosing nomogram.


Instruction: What is early anticoagulation associated with?

Output: reduced mortality for acute pulmonary embolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is early anticoagulation associated with?. ### Response: reduced mortality for acute pulmonary embolism.


Instruction: What is associated with reduced mortality for acute pulmonary embolism?

Output: Early anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with reduced mortality for acute pulmonary embolism?. ### Response: Early anticoagulation.


Instruction: Chest. 2010; 137 ( 6 ): 1382 - 1390.

Output: Chest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Chest. 2010; 137 ( 6 ): 1382 - 1390.. ### Response: Chest.


Instruction: Silbert JE, Rosenberg RD. The separation of active and inactive forms of heparin?

Output: Biochem Biophys Res Commun  .  1976

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Silbert JE, Rosenberg RD. The separation of active and inactive forms of heparin?. ### Response: Biochem Biophys Res Commun  .  1976.


Instruction: What is the name of the heparin-dependent inhib-itor of thrombin in human plasma?

Output: antithrombin III

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the heparin-dependent inhib-itor of thrombin in human plasma?. ### Response: antithrombin III.


Instruction: What does Tollefsen DM, Majerus DW, Blank MK believe to be?

Output: Heparin cofactor II

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Tollefsen DM, Majerus DW, Blank MK believe to be?. ### Response: Heparin cofactor II.


Instruction: What is thrombin in human plasma?

Output: inhib-itor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is thrombin in human plasma?. ### Response: inhib-itor.


Instruction: When was the J Biol Chem 257 ( 5 ): 2162 - 2169?

Output: 1982

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Biol Chem 257 ( 5 ): 2162 - 2169?. ### Response: 1982.


Instruction: What is the name of the new antithrombotic agents?

Output: Lancet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the new antithrombotic agents?. ### Response: Lancet.


Instruction: What is the name of the journal that published a study on new antithrombotic agents?

Output: Lancet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that published a study on new antithrombotic agents?. ### Response: Lancet.


Instruction: When did the Lancet issue 353 (9162): 1431 - 1436?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Lancet issue 353 (9162): 1431 - 1436?. ### Response: 1999.


Instruction: What is the structure of heparin oligosaccharide fragments with high anti-(factor Xa) activity containing the minimal antithrombin III-binding sequence?

Output: minimal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the structure of heparin oligosaccharide fragments with high anti-(factor Xa) activity containing the minimal antithrombin III-binding sequence?. ### Response: minimal.


Instruction: Chemical and 13C nuclear-magnetic-resonance studies?

Output: Biochem J

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Chemical and 13C nuclear-magnetic-resonance studies?. ### Response: Biochem J.


Instruction: What year did Biochem J 197 ( 3 ): 599 - 609 publish?

Output: 1981

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Biochem J 197 ( 3 ): 599 - 609 publish?. ### Response: 1981.


Instruction: What was the name of the journal published in 1981?

Output: Biochem J

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the journal published in 1981?. ### Response: Biochem J.


Instruction: What does heparin oligosaccharides and their neutralization by platelet factor 4 do?

Output: Anticoagulant activities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does heparin oligosaccharides and their neutralization by platelet factor 4 do?. ### Response: Anticoagulant activities.


Instruction: What year was Biochem J 218 ( 3 ): 725-732?

Output: 1984

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was Biochem J 218 ( 3 ): 725-732?. ### Response: 1984.


Instruction: 725 - 732. 16. Lindahl U, Thunberg L, Bäckström G, Riesenfeld J, Nordling K, Björk I.

Output: 725

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: 725 - 732. 16. Lindahl U, Thunberg L, Bäckström G, Riesenfeld J, Nordling K, Björk I.. ### Response: 725.


Instruction: What does extension and structural variability of the antithrombin-binding sequence in heparin do?

Output: Multiple functional domains

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does extension and structural variability of the antithrombin-binding sequence in heparin do?. ### Response: Multiple functional domains.


Instruction: When was the J Biol Chem 259 ( 20): 12368 - 12376?

Output: 1984

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Biol Chem 259 ( 20): 12368 - 12376?. ### Response: 1984.


Instruction: What is a simple rate law that describes the kinetics of the heparin-catalyzed reaction between antithrombin III and thrombine?

Output: Nesheim   ME

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a simple rate law that describes the kinetics of the heparin-catalyzed reaction between antithrombin III and thrombine?. ### Response: Nesheim   ME.


Instruction: What year did J Biol Chem publish 258 ( 23): 14708 - 14717?

Output: 1983

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did J Biol Chem publish 258 ( 23): 14708 - 14717?. ### Response: 1983.


Instruction: How many ( 23 ): 14708 - 14717?

Output: 258

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many ( 23 ): 14708 - 14717?. ### Response: 258.


Instruction: Oosta GM, Gardner WT, Beeler DL, Rosenberg RD. Multiple functional domains of what molecule?

Output: heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Oosta GM, Gardner WT, Beeler DL, Rosenberg RD. Multiple functional domains of what molecule?. ### Response: heparin.


Instruction: What are the multiple functional domains of the heparin molecule?

Output: oligosaccharides

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the multiple functional domains of the heparin molecule?. ### Response: oligosaccharides.


Instruction: What is the name of the study that evaluated the long-term safety and efficacy of a cholesterol-lowering diet in children with elevated low-density lipoprotein cholesterol?

Output: Dietary Intervention Study in Children

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated the long-term safety and efficacy of a cholesterol-lowering diet in children with elevated low-density lipoprotein cholesterol?. ### Response: Dietary Intervention Study in Children.


Instruction: What are the results of the Dietary Intervention Study in Children (DISC) Pediatrics?

Output: seven-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of the Dietary Intervention Study in Children (DISC) Pediatrics?. ### Response: seven-year.


Instruction: What is the name of the follow-up study on adolescents diet and metabolic syndrome in young women?

Output: Dietary Intervention Study in Children

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the follow-up study on adolescents diet and metabolic syndrome in young women?. ### Response: Dietary Intervention Study in Children.


Instruction: When was the DISC study conducted?

Output: 2001

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the DISC study conducted?. ### Response: 2001.


Instruction: What is a term for the study that looked at the effects of flaxseed in children?

Output: hyper -lipidemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a term for the study that looked at the effects of flaxseed in children?. ### Response: hyper -lipidemia.