Instruction: What revisions were made to the CPG?

Output: appropriate revisions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What revisions were made to the CPG?. ### Response: appropriate revisions.


Instruction: What was made available for peer review and comment?

Output: Draft 3 of the CPG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was made available for peer review and comment?. ### Response: Draft 3 of the CPG.


Instruction: What did the Champions present the CPG to the EBPWG for their approval?

Output: the guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Champions present the CPG to the EBPWG for their approval?. ### Response: the guideline.


Instruction: What was finalized based on the feedback received?

Output: the guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was finalized based on the feedback received?. ### Response: the guideline.


Instruction: The Work Group produced a set of what?

Output: guideline toolkit materials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The Work Group produced a set of what?. ### Response: guideline toolkit materials.


Instruction: When was the final VA/DoD HTN CPG submitted to the EBPWG?

Output: March 2020

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the final VA/DoD HTN CPG submitted to the EBPWG?. ### Response: March 2020.


Instruction: What are the 2018 Cholesterol Clinical Practice Guidelines?

Output: e1082–e1143

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the 2018 Cholesterol Clinical Practice Guidelines?. ### Response: e1082–e1143.


Instruction: What is the 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholerol?

Output: Reviewer Relationships With Industry and Other Entities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholerol?. ### Response: Reviewer Relationships With Industry and Other Entities.


Instruction: Who is the official reviewer for the University of Vermont Medical Center?

Output: Philip A. Ades

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the official reviewer for the University of Vermont Medical Center?. ### Response: Philip A. Ades.


Instruction: What is the name of the professional reviewer who works for the ACC Science and Quality Committee?

Output: Karen P . Alexander

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professional reviewer who works for the ACC Science and Quality Committee?. ### Response: Karen P . Alexander.


Instruction: Who is a professor of medicine at the Duke University medical center?

Output: Karen P . Alexander

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a professor of medicine at the Duke University medical center?. ### Response: Karen P . Alexander.


Instruction: What is the name of the official reviewer at AACVPRUniversity of South Florida?

Output: Theresa M. Beckie

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the official reviewer at AACVPRUniversity of South Florida?. ### Response: Theresa M. Beckie.


Instruction: Who is a member of the Council on Aspirin for Health and Prevention?

Output: Preventive Cardiovascular Nurses Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a member of the Council on Aspirin for Health and Prevention?. ### Response: Preventive Cardiovascular Nurses Association.


Instruction: What is the name of the committee that reviews Aspirin for Health and Prevention?

Output: Council on Aspirin for Health and Prevention - a committee of the Altarum Institute

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the committee that reviews Aspirin for Health and Prevention?. ### Response: Council on Aspirin for Health and Prevention - a committee of the Altarum Institute.


Instruction: Who is the official reviewer for the ADAAmerican Diabetes Association?

Output: William T. Cefalu

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the official reviewer for the ADAAmerican Diabetes Association?. ### Response: William T. Cefalu.


Instruction: Who is the official reviewer for the ACC/AHA Task Force on Clinical Practice Guidelines?

Output: arroa

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the official reviewer for the ACC/AHA Task Force on Clinical Practice Guidelines?. ### Response: arroa.


Instruction: What is the name of the professor of medicine at Oregon Health and Science University?

Output: Joaquin Cigarroa

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor of medicine at Oregon Health and Science University?. ### Response: Joaquin Cigarroa.


Instruction: What is the name of the professor and chair in the Department of Pediatrics at Children's Hospital Colorado?

Output: L. Joseph Butterfield

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor and chair in the Department of Pediatrics at Children's Hospital Colorado?. ### Response: L. Joseph Butterfield.


Instruction: Who is the Pediatrician-in-Chief and L. Joseph Butterfield Chair in Pediatrics?

Output: Children’s Hospital Colorado

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Pediatrician-in-Chief and L. Joseph Butterfield Chair in Pediatrics?. ### Response: Children’s Hospital Colorado.


Instruction: What company is the official reviewer for?

Output: AACVPR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What company is the official reviewer for?. ### Response: AACVPR.


Instruction: Where is the School of Pharmacy located?

Output: University of Colorado School of Medicine— Professor and Chair, Department of Pediatrics; Children’s Hospital Colorado—Pediatrician-in-Chief and L. Joseph Butterfield Chair in Pediatrics• Sanofi-Aventis None None None •  Novo Nordisk Inc. None NoneDave Dixon Official Reviewer—NLAVirginia Commonwealth University

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the School of Pharmacy located?. ### Response: University of Colorado School of Medicine— Professor and Chair, Department of Pediatrics; Children’s Hospital Colorado—Pediatrician-in-Chief and L. Joseph Butterfield Chair in Pediatrics• Sanofi-Aventis None None None •  Novo Nordisk Inc. None NoneDave Dixon Official Reviewer—NLAVirginia Commonwealth University.


Instruction: Who is the official reviewer for ACPMRidgecrest Regional Hospital?

Output: Earl W. Ferguson

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the official reviewer for ACPMRidgecrest Regional Hospital?. ### Response: Earl W. Ferguson.


Instruction: What is the name of the independent consultant?

Output: Earl W. Ferguson

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the independent consultant?. ### Response: Earl W. Ferguson.


Instruction: Who is the official reviewer for the ACC Board of Governors?

Output: Tyler J. Gluckman

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the official reviewer for the ACC Board of Governors?. ### Response: Tyler J. Gluckman.


Instruction: What is the name of the medical director of the St. Vincent Heart Clinic?

Output: Tyler J. Gluckman

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the medical director of the St. Vincent Heart Clinic?. ### Response: Tyler J. Gluckman.


Instruction: Who is a professor of clinic practice, medicine-cardiology?

Output: Edward A. Gill, Jr

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a professor of clinic practice, medicine-cardiology?. ### Response: Edward A. Gill, Jr.


Instruction: What is heparin versus aspirin for acute ischemic stroke with large artery occlusive disease?

Output: Low-molecular-weight

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is heparin versus aspirin for acute ischemic stroke with large artery occlusive disease?. ### Response: Low-molecular-weight.


Instruction: What is the Fraxiparin in Stroke Study for the treatment of?

Output: ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Fraxiparin in Stroke Study for the treatment of?. ### Response: ischemic stroke.


Instruction: What is the name of the study for the treatment of ischemic stroke?

Output: Fraxiparin in Stroke Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study for the treatment of ischemic stroke?. ### Response: Fraxiparin in Stroke Study.


Instruction: How many strokes were studied in the FISS-tris study?

Output: 470

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many strokes were studied in the FISS-tris study?. ### Response: 470.


Instruction: What type of therapy is used to treat atrial fibrillation?

Output: antithrombotic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is used to treat atrial fibrillation?. ### Response: antithrombotic.


Instruction: What does VISTA do to stroke patients with atrial fibrilla-tion?

Output: early antithrombotic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does VISTA do to stroke patients with atrial fibrilla-tion?. ### Response: early antithrombotic therapy.


Instruction: What is the name of the study that analyzed stroke patients receiving early antithrombotic therapy?

Output: VISTA Collaborators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that analyzed stroke patients receiving early antithrombotic therapy?. ### Response: VISTA Collaborators.


Instruction: When was the Eur J Neurol.22:1048-1055?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Eur J Neurol.22:1048-1055?. ### Response: 2015.


Instruction: What is the cause of acute ischemic stroke?

Output: cervical artery dissection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cause of acute ischemic stroke?. ### Response: cervical artery dissection.


Instruction: What was the result of cervical artery dissection?

Output: Comprehensive analysis of intra-arterial treatment for acute ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the result of cervical artery dissection?. ### Response: Comprehensive analysis of intra-arterial treatment for acute ischemic stroke.


Instruction: In what year was the J Neurointerv Surg published?

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was the J Neurointerv Surg published?. ### Response: 2017.


Instruction: How was aspiration pneu-monia reduced among dysphagia patients?

Output: Implementing oral care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was aspiration pneu-monia reduced among dysphagia patients?. ### Response: Implementing oral care.


Instruction: In what country is low-dose anticoagulation used to treat stroke?

Output: South African

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what country is low-dose anticoagulation used to treat stroke?. ### Response: South African.


Instruction: In what year did J Stroke Cerebrovasc Dis. 2013:22:1018-1027?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did J Stroke Cerebrovasc Dis. 2013:22:1018-1027?. ### Response: 2012.


Instruction: What year did S Afr J Commun Disord. 201663. doi: 10.4102/sajcd.v63i1.102 475?

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did S Afr J Commun Disord. 201663. doi: 10.4102/sajcd.v63i1.102 475?. ### Response: 2016.


Instruction: What is the name of the meta-analysis of randomized controlled trials?

Output: a systematic review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis of randomized controlled trials?. ### Response: a systematic review.


Instruction: What is J Stroke Cerebrovasc Dis. 2013;22:1018–1027?

Output: systematic review and meta-analysis of randomized controlled trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is J Stroke Cerebrovasc Dis. 2013;22:1018–1027?. ### Response: systematic review and meta-analysis of randomized controlled trials.


Instruction: What is the name of the prac-tice guideline from the American College of Physicians?

Output: Venous thromboembolism prophylaxis in hospitalized patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prac-tice guideline from the American College of Physicians?. ### Response: Venous thromboembolism prophylaxis in hospitalized patients.


Instruction: When was the Ann Intern Med 155:625-632?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Ann Intern Med 155:625-632?. ### Response: 2011.


Instruction: Where is the J Affect Disord located?

Output: American College of Physicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the J Affect Disord located?. ### Response: American College of Physicians.


Instruction: What is a meta-analysis of antidepressant treatments for post-stroke depression?

Output: Efficacy and safety of citalopram

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a meta-analysis of antidepressant treatments for post-stroke depression?. ### Response: Efficacy and safety of citalopram.


Instruction: What is the journal J Affect Disord 235:589-596?

Output: Cognitive behavioral therapy for post-stroke depression: a meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the journal J Affect Disord 235:589-596?. ### Response: Cognitive behavioral therapy for post-stroke depression: a meta-analysis.


Instruction: What is citalopram used for?

Output: treat-ment of poststroke depression

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is citalopram used for?. ### Response: treat-ment of poststroke depression.


Instruction: What is the name of the meta-analysis that examined the efficacy and safety of the drug?

Output: Fraxiparin in Stroke Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis that examined the efficacy and safety of the drug?. ### Response: Fraxiparin in Stroke Study.


Instruction: What is a network meta-analysis of pharmacotherapy for post-stroke de-pression?

Output: Efficacy and tolerability

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a network meta-analysis of pharmacotherapy for post-stroke de-pression?. ### Response: Efficacy and tolerability.


Instruction: What is the doi: 10.18632/oncotarget.23891 481?

Output: Oncotarget

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the doi: 10.18632/oncotarget.23891 481?. ### Response: Oncotarget.


Instruction: What is the name of the person who performed a comparative efficacy study?

Output: Zhao C

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the person who performed a comparative efficacy study?. ### Response: Zhao C.


Instruction: Who is the author of a randomized controlled trial?

Output: American College of Physicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of a randomized controlled trial?. ### Response: American College of Physicians.


Instruction: What are the names of the people who participated in a randomised controlled trial that was based on the results of the randomised trials?

Output: Geeganage CM, Sprigg N, Bath MW, Bath PM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the people who participated in a randomised controlled trial that was based on the results of the randomised trials?. ### Response: Geeganage CM, Sprigg N, Bath MW, Bath PM.


Instruction: What should be considered and modi fid as necessary in in-dividual patients?

Output: The form and intensity of physical activity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered and modi fid as necessary in in-dividual patients?. ### Response: The form and intensity of physical activity.


Instruction: What may still be important health bene fits even if physical activity falls belowtargets proposed for the general population?

Output: Practice Point 2.2.2: The form and intensity of physical activity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may still be important health bene fits even if physical activity falls belowtargets proposed for the general population?. ### Response: Practice Point 2.2.2: The form and intensity of physical activity.


Instruction: What should adults with high BP and CKD be treated with?

Output: a target systolic blood pressure(SBP) of <120 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should adults with high BP and CKD be treated with?. ### Response: a target systolic blood pressure(SBP) of <120 mm Hg.


Instruction: What is the target systolic blood pressure of 120 mm Hg?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the target systolic blood pressure of 120 mm Hg?. ### Response: <.


Instruction: What is tolerated, using standardized of fice BP measurement ( 2B)?

Output: systolic blood pressure(SBP) of <120 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is tolerated, using standardized of fice BP measurement ( 2B)?. ### Response: systolic blood pressure(SBP) of <120 mm Hg.


Instruction: What is potentially hazardous to apply the recommended SBP target of 120 mm Hg to?

Output: BP mea-surements

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is potentially hazardous to apply the recommended SBP target of 120 mm Hg to?. ### Response: BP mea-surements.


Instruction: What is the name of the antihypertensive drug used in patients with limited life expectancy?

Output: RAS inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the antihypertensive drug used in patients with limited life expectancy?. ### Response: RAS inhibitors.


Instruction: What is RASi?

Output: RAS inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is RASi?. ### Response: RAS inhibitors.


Instruction: Who is recommended to start renin-angiotensin-system inhibitors?

Output: people withhigh BP, CKD, and severely increased albuminuria (G1 –G4, A3) without diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is recommended to start renin-angiotensin-system inhibitors?. ### Response: people withhigh BP, CKD, and severely increased albuminuria (G1 –G4, A3) without diabetes.


Instruction: What is ACEi or ARB?

Output: RASi

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ACEi or ARB?. ### Response: RASi.


Instruction: What is RASi for?

Output: people with high BP, CKD, andmoderately-to-severely increased albuminuria (G1 –G4, A2 and A3) with diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is RASi for?. ### Response: people with high BP, CKD, andmoderately-to-severely increased albuminuria (G1 –G4, A2 and A3) with diabetes.


Instruction: What is RASi for people with high BP, CKD, and moderate-to-severely increased albuminuria with diabetes?

Output: ACEi or ARB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is RASi for people with high BP, CKD, and moderate-to-severely increased albuminuria with diabetes?. ### Response: ACEi or ARB.


Instruction: What is the practice point 3.2.1?

Output: It may be reasonable to treat people with high BP, CKD, and no albuminuria, with or withoutdiabetes, with RASi

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the practice point 3.2.1?. ### Response: It may be reasonable to treat people with high BP, CKD, and no albuminuria, with or withoutdiabetes, with RASi.


Instruction: What should be administered using the highest approved dose that is tolerated to achieve the bene fits described?

Output: RASi

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be administered using the highest approved dose that is tolerated to achieve the bene fits described?. ### Response: RASi.


Instruction: What should change in BP, serum creatinine, and serum potassium?

Output: checked within 2-4 weeks ofinitiation or increase in the dose of a RASi

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should change in BP, serum creatinine, and serum potassium?. ### Response: checked within 2-4 weeks ofinitiation or increase in the dose of a RASi.


Instruction: What should be checked within 2-4 weeks of initiation or increase in the dose of a RASi?

Output: Changes in BP, serum creatinine, and serum potassium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be checked within 2-4 weeks of initiation or increase in the dose of a RASi?. ### Response: Changes in BP, serum creatinine, and serum potassium.


Instruction: What can often be managed by measures to reduce the serumpotassium?

Output: Hyperkalemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can often be managed by measures to reduce the serumpotassium?. ### Response: Hyperkalemia.


Instruction: What can often be managed by measures to reduce the serumpotassium levels rather than decreasing the dose or stopping RASi?

Output: Hyperkalemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can often be managed by measures to reduce the serumpotassium levels rather than decreasing the dose or stopping RASi?. ### Response: Hyperkalemia.


Instruction: Continue ACEi or ARB therapy unless serum creatinine rises by more than 30% within 4 weeks?

Output: initiation of treatment or an increase in dose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Continue ACEi or ARB therapy unless serum creatinine rises by more than 30% within 4 weeks?. ### Response: initiation of treatment or an increase in dose.


Instruction: What is a possible cause of kidney failure?

Output: diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a possible cause of kidney failure?. ### Response: diabetes.


Instruction: What is the estimated eGFR per 1.73 m2?

Output: <15 ml/min

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the estimated eGFR per 1.73 m2?. ### Response: <15 ml/min.


Instruction: What is effective for management of refractory hypertension?

Output: Mineralocorticoid receptor antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is effective for management of refractory hypertension?. ### Response: Mineralocorticoid receptor antagonists.


Instruction: What is the effect of mineralocorticoid receptor antagonists?

Output: management of refractory hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of mineralocorticoid receptor antagonists?. ### Response: management of refractory hypertension.


Instruction: What did not show a significant reduction of SBP in patients with resistant hypertension?

Output: CLINICAL STATEMENTS  AND GUIDELINES

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did not show a significant reduction of SBP in patients with resistant hypertension?. ### Response: CLINICAL STATEMENTS  AND GUIDELINES.


Instruction: What are other strategies awaiting clinical validation in the hypertension patient?

Output: targeting excessive sympathetic nerve activity by carotid body denervation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are other strategies awaiting clinical validation in the hypertension patient?. ### Response: targeting excessive sympathetic nerve activity by carotid body denervation.


Instruction: What are awaiting clinical validation in the hypertension and HF populations?

Output: Other strategies such as targeting excessive sympathetic nerve activity by carotid body denervation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are awaiting clinical validation in the hypertension and HF populations?. ### Response: Other strategies such as targeting excessive sympathetic nerve activity by carotid body denervation.


Instruction: What classes of drugs should be avoided in patients with HFrEF with a history of hypertension?

Output: nondihydropyridine cal-cium channel blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What classes of drugs should be avoided in patients with HFrEF with a history of hypertension?. ### Response: nondihydropyridine cal-cium channel blockers.


Instruction: What are two nondihydropyridine cal-cium channel blockers?

Output: diltiazem and verapamil

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are two nondihydropyridine cal-cium channel blockers?. ### Response: diltiazem and verapamil.


Instruction: What is diltiazem and verapamil?

Output: nondihydropyridine cal-cium channel blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is diltiazem and verapamil?. ### Response: nondihydropyridine cal-cium channel blockers.


Instruction: Amlodipine appeared to be safe in what trial?

Output: PRAISE trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Amlodipine appeared to be safe in what trial?. ### Response: PRAISE trial.


Instruction: What drug was associated with increased mortality in patients with HF?

Output: moxonidine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug was associated with increased mortality in patients with HF?. ### Response: moxonidine.


Instruction: What was felodipine?

Output: amlodipine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was felodipine?. ### Response: amlodipine.


Instruction: In the 2013 HF guidelines, most calcium channel-blocking drugs are not recommended except what?

Output: amlodipine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the 2013 HF guidelines, most calcium channel-blocking drugs are not recommended except what?. ### Response: amlodipine.


Instruction: What may need to be avoided or used with caution in patients with HFrEF?

Output: cen-trally acting norepinephrine-depleting agents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may need to be avoided or used with caution in patients with HFrEF?. ### Response: cen-trally acting norepinephrine-depleting agents.


Instruction: What was discontinued in the ALLHAT trial because of a 2-fold increase in the risk of developing HF?

Output: α -blocker doxazosin arm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was discontinued in the ALLHAT trial because of a 2-fold increase in the risk of developing HF?. ### Response: α -blocker doxazosin arm.


Instruction: How many times increased the risk of developing HF compared with chlorthalidone?

Output: 2-fold

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many times increased the risk of developing HF compared with chlorthalidone?. ### Response: 2-fold.


Instruction: What study excluded patients with established HF?

Output: ALLHAT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What study excluded patients with established HF?. ### Response: ALLHAT.


Instruction: What are the safety and efficacy of  -blockers in the management of patients with HF with hypertension currently unclear?

Output: most calcium channel–blocking drugs except amlodipine are not recommended

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the safety and efficacy of  -blockers in the management of patients with HF with hypertension currently unclear?. ### Response: most calcium channel–blocking drugs except amlodipine are not recommended.


Instruction: What should be avoided because of their renin-related salt and fluid-retaining effects?

Output: Potent direct-acting vasodilators such as minoxidil

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be avoided because of their renin-related salt and fluid-retaining effects?. ### Response: Potent direct-acting vasodilators such as minoxidil.


Instruction: Nonsteroidal anti-inflammatory agents should be used with caution in what patients?

Output: patients with HFrEF with a history of hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Nonsteroidal anti-inflammatory agents should be used with caution in what patients?. ### Response: patients with HFrEF with a history of hypertension.


Instruction: What are the effects of HFpEF on BP, volume status, and renal function?

Output: Nonsteroidal anti-inflammatory agents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the effects of HFpEF on BP, volume status, and renal function?. ### Response: Nonsteroidal anti-inflammatory agents.


Instruction: What type of patients with HF and preserved LVEF are especially susceptible to hypertension?

Output: elderly women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of patients with HF and preserved LVEF are especially susceptible to hypertension?. ### Response: elderly women.


Instruction: What may patients with HFpEF respond particularly well to the treatment of hypertension with regression of hypertrophy84 and improvement in filling pressures?

Output: 84,85 Most patients with HFpEF require treat-ment with cardiac medications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may patients with HFpEF respond particularly well to the treatment of hypertension with regression of hypertrophy84 and improvement in filling pressures?. ### Response: 84,85 Most patients with HFpEF require treat-ment with cardiac medications.


Instruction: What may some patients have without LV systolic dysfunction?

Output: atrial dilatation, cardiac enlargement, and wall motion abnormalities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may some patients have without LV systolic dysfunction?. ### Response: atrial dilatation, cardiac enlargement, and wall motion abnormalities.


Instruction: What do most patients with HFpEF require treat-ment with?

Output: cardiac medications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do most patients with HFpEF require treat-ment with?. ### Response: cardiac medications.


Instruction: What are the comorbidities of hypertension, diabetes mellitus, coronary artery dis-ease, and atrial fibrillation?

Output: Most patients with HFpEF require treat-ment with cardiac medications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the comorbidities of hypertension, diabetes mellitus, coronary artery dis-ease, and atrial fibrillation?. ### Response: Most patients with HFpEF require treat-ment with cardiac medications.


Instruction: The 2013 HF guidelines sug-gest the use of what?

Output: β-blocking agents, ACE inhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The 2013 HF guidelines sug-gest the use of what?. ### Response: β-blocking agents, ACE inhibitors.


Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al.


Instruction: What is the DOI: 10.1161/CIR.0000000000000923 February 2, 2021?

Output: Otto et al 2020 ACC/AHA Guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the DOI: 10.1161/CIR.0000000000000923 February 2, 2021?. ### Response: Otto et al 2020 ACC/AHA Guideline.


Instruction: What was the difference in all-cause mortality rate at 6 months in the early surgery group versus the conven-tional treatment groups?

Output: 3% and 5%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the difference in all-cause mortality rate at 6 months in the early surgery group versus the conven-tional treatment groups?. ### Response: 3% and 5%,.


Instruction: What was a marked reduction in the number of embolic events?

Output: 0% in the early surgery group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a marked reduction in the number of embolic events?. ### Response: 0% in the early surgery group.


Instruction: What percentage of the conventional treatment group required surgery during the initial hospitalization or during the follow-up phase?

Output: 77%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the conventional treatment group required surgery during the initial hospitalization or during the follow-up phase?. ### Response: 77%.


Instruction: What is an independent risk factor for postoperative death in patients with HF?

Output: age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an independent risk factor for postoperative death in patients with HF?. ### Response: age.


Instruction: What is an independent risk factor for postoperative death in patients with IE?

Output: Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an independent risk factor for postoperative death in patients with IE?. ### Response: Stroke.


Instruction: What is hindered by the lack of RCTs and reliance on single-center experiences?

Output: Recommendations about the timing of opera-tive intervention after a stroke in the setting of IE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hindered by the lack of RCTs and reliance on single-center experiences?. ### Response: Recommendations about the timing of opera-tive intervention after a stroke in the setting of IE.


Instruction: In early observa-tional data, there was a significantly decreased risk of what?

Output: in-hospital death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In early observa-tional data, there was a significantly decreased risk of what?. ### Response: in-hospital death.


Instruction: What was the risk of in-hospital death when surgery was per -formed >4 weeks after the stroke?

Output: decreased

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk of in-hospital death when surgery was per -formed >4 weeks after the stroke?. ### Response: decreased.


Instruction: What was not risk adjusted in an observational study?

Output: RCTs and reliance on single-center experiences. In early observa-tional data, there was a significantly decreased risk of in-hospital death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not risk adjusted in an observational study?. ### Response: RCTs and reliance on single-center experiences. In early observa-tional data, there was a significantly decreased risk of in-hospital death.


Instruction: What risk of in-hospital death was not significantly higher in the group who underwent surgery within a median time from admission to operation of 5 days?

Output: the risk of in-hospital death was not significantly higher in the group who underwent surgery within a median time from admission to operation of 5 days, with only a 1% risk of perioperative hemorrhagic conversion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What risk of in-hospital death was not significantly higher in the group who underwent surgery within a median time from admission to operation of 5 days?. ### Response: the risk of in-hospital death was not significantly higher in the group who underwent surgery within a median time from admission to operation of 5 days, with only a 1% risk of perioperative hemorrhagic conversion.


Instruction: What was the risk of perioperative hemorrhagic conversion?

Output: 1%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk of perioperative hemorrhagic conversion?. ### Response: 1%.


Instruction: How long did it take to undergo surgery?

Output: 5 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take to undergo surgery?. ### Response: 5 days.


Instruction: How long after a hemorrhagic stroke do patients with IE have a prohibitively high surgical risk?

Output: 4 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after a hemorrhagic stroke do patients with IE have a prohibitively high surgical risk?. ### Response: 4 weeks.


Instruction: What did one multicenter observational study71 show?

Output: wide variation in patient deaths

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did one multicenter observational study71 show?. ### Response: wide variation in patient deaths.


Instruction: What was the percentage of new postop-erative bleeds in patients whose surgery was performed in the first 2 weeks?

Output: 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the percentage of new postop-erative bleeds in patients whose surgery was performed in the first 2 weeks?. ### Response: 50%.


Instruction: What percentage of patients had surgery done in the third week?

Output: 33%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients had surgery done in the third week?. ### Response: 33%.


Instruction: What percentage of patients had surgery performed in the third week?

Output: 33%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients had surgery performed in the third week?. ### Response: 33%.


Instruction: What percentage had surgery done at least 21 days after the neuro-logical event?

Output: 20%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage had surgery done at least 21 days after the neuro-logical event?. ### Response: 20%.


Instruction: PREGNANCY AND VHDThe physiological hemodynamic changes associated with pregnancy are generally well tolerated in women with what?

Output: structurally normal hearts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: PREGNANCY AND VHDThe physiological hemodynamic changes associated with pregnancy are generally well tolerated in women with what?. ### Response: structurally normal hearts.


Instruction: What may pose signifi-cant challenges during pregnancy and delivery for women with VHD?

Output: the hemodynamic burden

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may pose signifi-cant challenges during pregnancy and delivery for women with VHD?. ### Response: the hemodynamic burden.


Instruction: What are recommendations for Initial Management of Women With VHD Before and During Pregnancy?

Output: Referenced studies that support the recommendations are summarized in Online Data Supplement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are recommendations for Initial Management of Women With VHD Before and During Pregnancy?. ### Response: Referenced studies that support the recommendations are summarized in Online Data Supplement.


Instruction: Where are the studies that support the recommendations summarized?

Output: Online Data Supplement 43

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are the studies that support the recommendations summarized?. ### Response: Online Data Supplement 43.


Instruction: Women with suspected valve disease who are considering pregnancy should undergo what before pregnancy?

Output: a clinical evaluation and TTE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Women with suspected valve disease who are considering pregnancy should undergo what before pregnancy?. ### Response: a clinical evaluation and TTE.


Instruction: What has been shown to be associated with a poor prognosis in patients with previous CABG?

Output: LAD artery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been shown to be associated with a poor prognosis in patients with previous CABG?. ### Response: LAD artery.


Instruction: How many patients with diseased SVGs did not undergo reoperation or PCI within 1 year of angiography?

Output: 723

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with diseased SVGs did not undergo reoperation or PCI within 1 year of angiography?. ### Response: 723.


Instruction: What was associated with decreased rates of survival?

Output: stenosis of a graft to the LAD artery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with decreased rates of survival?. ### Response: stenosis of a graft to the LAD artery.


Instruction: What is an indication for reoperation?

Output: a /H1102250% stenosis in a graft tothe LAD artery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an indication for reoperation?. ### Response: a /H1102250% stenosis in a graft tothe LAD artery.


Instruction: Patients without ischemia in the LAD artery distribution do not derive what?

Output: a survival benefit from repeat CABG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients without ischemia in the LAD artery distribution do not derive what?. ### Response: a survival benefit from repeat CABG.


Instruction: How many patients had patent LIMA grafts to the LADartery and ischemia in the distribution of the right and/or leftcircumflex arteries treated with repeat CABG?

Output: 4640

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients had patent LIMA grafts to the LADartery and ischemia in the distribution of the right and/or leftcircumflex arteries treated with repeat CABG?. ### Response: 4640.


Instruction: What was not observed in either revascularization group compared with those treated medically?

Output: improvement insurvival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not observed in either revascularization group compared with those treated medically?. ### Response: improvement insurvival.


Instruction: Why is reoperative CABG associated with higher risk?

Output: higher patient risk profiles

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is reoperative CABG associated with higher risk?. ### Response: higher patient risk profiles.


Instruction: What is associated with the technical difficulty of repeat CABG?

Output: higher rates of morbidity and mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with the technical difficulty of repeat CABG?. ### Response: higher rates of morbidity and mortality.


Instruction: What is associated with higher rates of morbidity and mortality than primary CABG?

Output: reoperative CABG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with higher rates of morbidity and mortality than primary CABG?. ### Response: reoperative CABG.


Instruction: With advances in surgical tech-niques, some groups have reported a decline in mortality rate for patients undergoing repeat CABG.

Output: 945,1229–1235

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: With advances in surgical tech-niques, some groups have reported a decline in mortality rate for patients undergoing repeat CABG.. ### Response: 945,1229–1235.


Instruction: What did an observa-tional study suggest that the higher operative risk withreoperation is related to?

Output: higher patient risk profiles

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did an observa-tional study suggest that the higher operative risk withreoperation is related to?. ### Response: higher patient risk profiles.


Instruction: Why is the higher operative risk withreoperation related to the higher patient risk profiles?

Output: technical issues

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is the higher operative risk withreoperation related to the higher patient risk profiles?. ### Response: technical issues.


Instruction: What has improved surgical techniquesneutralized the risk associated with the complexity of repeatCABG?

Output: advances in surgical tech-niques

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has improved surgical techniquesneutralized the risk associated with the complexity of repeatCABG?. ### Response: advances in surgical tech-niques.


Instruction: What are the reasons for the higher mortality rate in CABG patients?

Output: technical issues

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the reasons for the higher mortality rate in CABG patients?. ### Response: technical issues.


Instruction: What is the survival rate after repeat CABG lower than afterprimary CABG?

Output: 93.1%, 90.5%, 85.9%, and 80.5%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the survival rate after repeat CABG lower than afterprimary CABG?. ### Response: 93.1%, 90.5%, 85.9%, and 80.5%,.


Instruction: Where was a multicenter study done?

Output: Australia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where was a multicenter study done?. ### Response: Australia.


Instruction: What were the rates in reoperative CABG patients?

Output: 93.1%, 90.5%, 85.9%, and 80.5%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the rates in reoperative CABG patients?. ### Response: 93.1%, 90.5%, 85.9%, and 80.5%,.


Instruction: What was the difference in long-term survival rate after adjusting for differences in riskprofiles?

Output: nodifference

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the difference in long-term survival rate after adjusting for differences in riskprofiles?. ### Response: nodifference.


Instruction: What is lesssuccessful than primary CABG at relieving angina?

Output: repeat CABG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is lesssuccessful than primary CABG at relieving angina?. ### Response: repeat CABG.


Instruction: What did a 2004 quality-of-life analysis report that repeat CABG was aseffective as?

Output: primary CABG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a 2004 quality-of-life analysis report that repeat CABG was aseffective as?. ### Response: primary CABG.


Instruction: What was as effective as primary CABG in relieving angina and improv-ing functional capacity and quality of life?

Output: medical therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was as effective as primary CABG in relieving angina and improv-ing functional capacity and quality of life?. ### Response: medical therapy.


Instruction: Patients With Previous Stroke had what type of stroke?

Output: CABG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients With Previous Stroke had what type of stroke?. ### Response: CABG.


Instruction: What are the comorbidities of hypertension, diabetes mellitus, obesity, hyperlipidemia, and metabolic syndrome common in patients with heart failure?

Output: affect clinical outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the comorbidities of hypertension, diabetes mellitus, obesity, hyperlipidemia, and metabolic syndrome common in patients with heart failure?. ### Response: affect clinical outcomes.


Instruction: What affects clinical outcomes of heart failure patients?

Output: The comorbidities of hypertension, diabetes mellitus, obesity, hyperlipidemia, and metabolic syndrome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What affects clinical outcomes of heart failure patients?. ### Response: The comorbidities of hypertension, diabetes mellitus, obesity, hyperlipidemia, and metabolic syndrome.


Instruction: What are the contributory roles to clinical outcomes not pre-dictable?

Output: pa-tients with established HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the contributory roles to clinical outcomes not pre-dictable?. ### Response: pa-tients with established HF.


Instruction: What is the management of patients with established HF?

Output: challenging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the management of patients with established HF?. ### Response: challenging.


Instruction: How have recent guidelines addressed the role of lifestyle modification?

Output: treatment of blood cholesterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How have recent guidelines addressed the role of lifestyle modification?. ### Response: treatment of blood cholesterol.


Instruction: What has the Eighth Joint Na-tional Committee addressed?

Output: management of hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has the Eighth Joint Na-tional Committee addressed?. ### Response: management of hypertension.


Instruction: What did the guidelines not specifically address?

Output: the management of such comorbidities in patients with HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the guidelines not specifically address?. ### Response: the management of such comorbidities in patients with HF.


Instruction: What did the most recent ACCF/AHA HF practice guidelines address in 2013?

Output: the overall management of comorbidities in patients with HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the most recent ACCF/AHA HF practice guidelines address in 2013?. ### Response: the overall management of comorbidities in patients with HF.


Instruction: What did these guidelines not specifically address in patients with HF?

Output: management of such comorbidities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did these guidelines not specifically address in patients with HF?. ### Response: management of such comorbidities.


Instruction: What is lacking in the AHA scientific statement?

Output: specific and detailed recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is lacking in the AHA scientific statement?. ### Response: specific and detailed recommendations.


Instruction: What is the purpose of this AHA statement? What does this statement summarize?

Output: data relevant to contributory risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of this AHA statement? What does this statement summarize?. ### Response: data relevant to contributory risk.


Instruction: What is the purpose of this document?

Output: to summarize data relevant to contributory risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of this document?. ### Response: to summarize data relevant to contributory risk.


Instruction: What are the recommendations in this document based on?

Output: published studies and the multidisciplinary expertise of the writing group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the recommendations in this document based on?. ### Response: published studies and the multidisciplinary expertise of the writing group.


Instruction: What is a worldwide epidemic?

Output: Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a worldwide epidemic?. ### Response: Hypertension.


Instruction: How much of the population is >60 years of age?

Output: 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the population is >60 years of age?. ### Response: 50%.


Instruction: What percentage of the population is over 60 years old?

Output: 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the population is over 60 years old?. ### Response: 50%.


Instruction: What is hypertension defined as?

Output: repeatedly elevated blood pressure (BP) exceeding 140/90 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hypertension defined as?. ### Response: repeatedly elevated blood pressure (BP) exceeding 140/90 mm Hg.


Instruction: Hypertension is defined as a repeatedly elevated blood pressure exceeding what?

Output: 140/90 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hypertension is defined as a repeatedly elevated blood pressure exceeding what?. ### Response: 140/90 mm Hg.


Instruction: What are antihypertensive medications used for?

Output: lifestyle modification

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are antihypertensive medications used for?. ### Response: lifestyle modification.


Instruction: What is hypertension associated with independently of other risk factors?

Output: increased cardiovascular and all-cause mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hypertension associated with independently of other risk factors?. ### Response: increased cardiovascular and all-cause mortality.


Instruction: Why is specific HF mortality attributable to hypertension underreported?

Output: competing adjudication for stroke or myocardial infarction (MI) at the end of the spectrum of hypertensive cardiovascular death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is specific HF mortality attributable to hypertension underreported?. ### Response: competing adjudication for stroke or myocardial infarction (MI) at the end of the spectrum of hypertensive cardiovascular death.


Instruction: What is the end of the spectrum of hypertensive cardiovascular death?

Output: stroke or myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the end of the spectrum of hypertensive cardiovascular death?. ### Response: stroke or myocardial infarction.


Instruction: Who is Biykem Bozkurt, MD, PhD, FAHA?

Output: Chair

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Biykem Bozkurt, MD, PhD, FAHA?. ### Response: Chair.


Instruction: Who is Robert S. Baltimore's Chair?

Output: Michael Gewitz, MD, FAHA, Vice Chair

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Robert S. Baltimore's Chair?. ### Response: Michael Gewitz, MD, FAHA, Vice Chair.


Instruction: Who is Michael Gewitz's vice chair?

Output: Robert S. Baltimore

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Michael Gewitz's vice chair?. ### Response: Robert S. Baltimore.


Instruction: What is Larry M. Baddour's profession?

Output: MD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Larry M. Baddour's profession?. ### Response: MD.


Instruction: Who is on behalf of the American Heart Association Rheumatic Fever, Endocarditis and Kawasaki Disease Committee of the Council on Cardiovascular Disease in the Young?

Output: Rodney Willoughby, Jr, MD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is on behalf of the American Heart Association Rheumatic Fever, Endocarditis and Kawasaki Disease Committee of the Council on Cardiovascular Disease in the Young?. ### Response: Rodney Willoughby, Jr, MD.


Instruction: When was the document downloaded from http://ahajournals.org?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the document downloaded from http://ahajournals.org?. ### Response: April 28, 2023.


Instruction: What is the CHA2DS2-VASc score?

Output: 1 in males and 2 in females

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the CHA2DS2-VASc score?. ### Response: 1 in males and 2 in females.


Instruction: Women with AF are likely to be older and have an increased risk of what?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Women with AF are likely to be older and have an increased risk of what?. ### Response: stroke.


Instruction: What does not convey increased risk?

Output: Female sex alone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not convey increased risk?. ### Response: Female sex alone.


Instruction: What does female sex alone not convey increased risk in the absence of?

Output: other factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does female sex alone not convey increased risk in the absence of?. ### Response: other factors.


Instruction: What did recent studies address the benefit of anticoagulation among patients with AF who have 1 non-sex-related AF risk factor?

Output: CHA2DS2-VASc score of 1 in males and 2 in females

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did recent studies address the benefit of anticoagulation among patients with AF who have 1 non-sex-related AF risk factor?. ### Response: CHA2DS2-VASc score of 1 in males and 2 in females.


Instruction: What was the CHA2DS2-VASc score in males and 2 in females?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the CHA2DS2-VASc score in males and 2 in females?. ### Response: 1.


Instruction: What did the authors find about nonanticoagulated patients with AF who had 1 non-sex-related stroke risk fac-tor?

Output: increased risk of serious cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the authors find about nonanticoagulated patients with AF who had 1 non-sex-related stroke risk fac-tor?. ### Response: increased risk of serious cardiovascular events.


Instruction: Who had an increased risk of serious cardiovascular events during follow-up?

Output: nonanticoagulated patients with AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who had an increased risk of serious cardiovascular events during follow-up?. ### Response: nonanticoagulated patients with AF.


Instruction: What was associated with a small positive net clinical ben-efit?

Output: warfarin anticoagulation use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with a small positive net clinical ben-efit?. ### Response: warfarin anticoagulation use.


Instruction: What is 50% renally excreted and dosed once a day?

Output: Edoxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is 50% renally excreted and dosed once a day?. ### Response: Edoxaban.


Instruction: What is not recommended in patients with end-stage renal disease or on dialysis?

Output: Edoxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended in patients with end-stage renal disease or on dialysis?. ### Response: Edoxaban.


Instruction: Limited single-dose pharmacokinetic data have been published for what?

Output: rivaroxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Limited single-dose pharmacokinetic data have been published for what?. ### Response: rivaroxaban.


Instruction: What has been published for rivaroxaban use in patients with end-stage kidney disease on dialysis?

Output: Limited single-dose pharmacokinetic data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been published for rivaroxaban use in patients with end-stage kidney disease on dialysis?. ### Response: Limited single-dose pharmacokinetic data.


Instruction: What have been stud-ied by using prescription patterns?

Output: Dabigatran and rivaroxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have been stud-ied by using prescription patterns?. ### Response: Dabigatran and rivaroxaban.


Instruction: Which drugs were associated with a higher risk of hospitalization or death from bleeding than warfarin?

Output: Dabigatran and rivaroxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which drugs were associated with a higher risk of hospitalization or death from bleeding than warfarin?. ### Response: Dabigatran and rivaroxaban.


Instruction: What was the name of the randomized, phase II study to evaluate the safety and pharmacokinetics of Oral Dabigatran Etexilate in Patients After Heart Valve Replacement?

Output: RE-ALIGN trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the randomized, phase II study to evaluate the safety and pharmacokinetics of Oral Dabigatran Etexilate in Patients After Heart Valve Replacement?. ### Response: RE-ALIGN trial.


Instruction: How many patients were enrolled in the RE-ALIGN trial?

Output: 18-75 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were enrolled in the RE-ALIGN trial?. ### Response: 18-75 years of age.


Instruction: What was the age range of patients enrolled in a study of dabigatran versus warfarin?

Output: 18-75 years of age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the age range of patients enrolled in a study of dabigatran versus warfarin?. ### Response: 18-75 years of age.


Instruction: How many days before randomization did a patient undergo a mechanical valve replacement in the aortic or mitral position (population A)?

Output: 7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many days before randomization did a patient undergo a mechanical valve replacement in the aortic or mitral position (population A)?. ### Response: 7.


Instruction: How many patients were enrolled in the dabigatran trial?

Output: 252

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were enrolled in the dabigatran trial?. ### Response: 252.


Instruction: Why was the trial stopped?

Output: unacceptable thromboembolic and bleeding event rates in the dabigatran group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the trial stopped?. ### Response: unacceptable thromboembolic and bleeding event rates in the dabigatran group.


Instruction: What group had unacceptable thromboembolic and bleeding events?

Output: dabigatran

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What group had unacceptable thromboembolic and bleeding events?. ### Response: dabigatran.


Instruction: What is lacking for mechanical Download from http://ahajournals.org by on April 23, 2023?

Output: drug safety and efficacy information

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is lacking for mechanical Download from http://ahajournals.org by on April 23, 2023?. ### Response: drug safety and efficacy information.


Instruction: How do we put our recommendations into practice?

Output: developing new andconvenient ways to disseminate our recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do we put our recommendations into practice?. ### Response: developing new andconvenient ways to disseminate our recommendations.


Instruction: What is one of our goals?

Output: reduction in the burden of VTE in individual patientsand in the general population

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of our goals?. ### Response: reduction in the burden of VTE in individual patientsand in the general population.


Instruction: Who was the chair of the panel?

Output: C. K.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the chair of the panel?. ### Response: C. K..


Instruction: Who were the executive committee members of the panel?

Output: C. K., E. A.,A. B., J. O., D. J., and L .M.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who were the executive committee members of the panel?. ### Response: C. K., E. A.,A. B., J. O., D. J., and L .M..


Instruction: What was the topic editor for “Treatment of Acute Pulmonary Embolism Out of Hospital?”

Output: C. K. and N. S.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the topic editor for “Treatment of Acute Pulmonary Embolism Out of Hospital?”. ### Response: C. K. and N. S..


Instruction: What were the topic editors for for “Pulmonary Thromboendarterectomy in Hospital”?

Output: E. A. and J. O.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the topic editors for for “Pulmonary Thromboendarterectomy in Hospital”?. ### Response: E. A. and J. O..


Instruction: Who were the topiceditors for “Pulmonary Thromboendarterectomy in the Treatment of Pulmonary Hypertension”?

Output: C. K. and D. J.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who were the topiceditors for “Pulmonary Thromboendarterectomy in the Treatment of Pulmonary Hypertension”?. ### Response: C. K. and D. J..


Instruction: What were E. K. and A. B. the topic editors for “Compression Stocking to Prevent Post-Thrombotic Syndrome?”

Output: Thrombolytic Therapy in Patients with Upper Extremity Deep VeinThrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were E. K. and A. B. the topic editors for “Compression Stocking to Prevent Post-Thrombotic Syndrome?”. ### Response: Thrombolytic Therapy in Patients with Upper Extremity Deep VeinThrombosis.


Instruction: Who were the topic editors for “Thrombolytic Therapy in Patients with Upper Extremity Deep VeinThroombosis”?

Output: E. K. and A. B.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who were the topic editors for “Thrombolytic Therapy in Patients with Upper Extremity Deep VeinThroombosis”?. ### Response: E. K. and A. B..


Instruction: What was the topic editor for “Managementof Recurrent Venous Thrombomboembolism on Anticoagulant Therapy?”

Output: D. J. and C. S. K.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the topic editor for “Managementof Recurrent Venous Thrombomboembolism on Anticoagulant Therapy?”. ### Response: D. J. and C. S. K..


Instruction: What were the topics editors for?

Output: “Systemic Thrombolytic Therapy for PulmonaryEmbolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the topics editors for?. ### Response: “Systemic Thrombolytic Therapy for PulmonaryEmbolism.


Instruction: Who were the topic editors for "Catheter-DirectedThrombolysis for Acute Deep Vein Thromatosis of the Leg"?

Output: M. H. and H. B.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who were the topic editors for "Catheter-DirectedThrombolysis for Acute Deep Vein Thromatosis of the Leg"?. ### Response: M. H. and H. B..


Instruction: What was the topic editor for "Duration of Anticoagulant Therapy?"

Output: M. H. andJ. V.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the topic editor for "Duration of Anticoagulant Therapy?". ### Response: M. H. andJ. V..


Instruction: Who were the topic editors for "Whether to AnticoagulateSubsegmental Pulmonary Embolism"?

Output: L. M. and C. S. K.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who were the topic editors for "Whether to AnticoagulateSubsegmental Pulmonary Embolism"?. ### Response: L. M. and C. S. K..


Instruction: What was the topic editor for "Catheter-Based Thrombus Removal for the InitialTreatment of pulmonary embolism?"

Output: S. S., T. M. and P. W.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the topic editor for "Catheter-Based Thrombus Removal for the InitialTreatment of pulmonary embolism?". ### Response: S. S., T. M. and P. W..


Instruction: Who were the topic editors for Choice of Long-Term (First 3 Months) and Extended(No Scheduled Stop Date) Anticoagulant?

Output: S.W. and T. M.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who were the topic editors for Choice of Long-Term (First 3 Months) and Extended(No Scheduled Stop Date) Anticoagulant?. ### Response: S.W. and T. M..


Instruction: What was the topic editor for Systemic Thrombolytic Therapy for PulmonaryEmbolism?

Output: S. S., S. W. and J. V.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the topic editor for Systemic Thrombolytic Therapy for PulmonaryEmbolism?. ### Response: S. S., S. W. and J. V..


Instruction: Who were the topic editors for “Aspirinfor Extended Treatment of Venous Thromboembolism”?

Output: L. M. and P. W.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who were the topic editors for “Aspirinfor Extended Treatment of Venous Thromboembolism”?. ### Response: L. M. and P. W..


Instruction: What was the topic editor for “Role of Inferior Vena CavalFilter in Addition to Anticoagulation in Patients with Acute DeepVein thrombosis or Pulmonary Embolism?”

Output: L. M. andC. S. K.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the topic editor for “Role of Inferior Vena CavalFilter in Addition to Anticoagulation in Patients with Acute DeepVein thrombosis or Pulmonary Embolism?”. ### Response: L. M. andC. S. K..


Instruction: Who was the GOC liaison to the panel?

Output: A. B.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the GOC liaison to the panel?. ### Response: A. B..


Instruction: Who was an overall guideline editor?

Output: L. M.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was an overall guideline editor?. ### Response: L. M..


Instruction: How many systematic reviews did E. A.A. author on in the past 3 years?

Output: anumber

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many systematic reviews did E. A.A. author on in the past 3 years?. ### Response: anumber.


Instruction: Who sponsored H. B.'s speaking engagements?

Output: Sano

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who sponsored H. B.'s speaking engagements?. ### Response: Sano.


Instruction: What type of funding does Daiichi-Sankyo receive?

Output: grant funding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of funding does Daiichi-Sankyo receive?. ### Response: grant funding.


Instruction: What is the name of the coauthor of studies using rivaroxaban and edoxaban?

Output: H. B.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the coauthor of studies using rivaroxaban and edoxaban?. ### Response: H. B..


Instruction: What type of funding did Daiichi-Sankyo receive?

Output: grant funding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of funding did Daiichi-Sankyo receive?. ### Response: grant funding.


Instruction: What is the 2015 ACC/AHA/HRS SVT Guideline e529Verapamil 120 mg daily in divided or single dose with long-acting formulations?

Output: Page et al  2015 ACC/AHA/HRS SVT Guideline  e529Verapamil 120 mg daily in divided or single dose with long-acting formulations480 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2015 ACC/AHA/HRS SVT Guideline e529Verapamil 120 mg daily in divided or single dose with long-acting formulations?. ### Response: Page et al  2015 ACC/AHA/HRS SVT Guideline  e529Verapamil 120 mg daily in divided or single dose with long-acting formulations480 mg.


Instruction: What is worsening HF in patients with pre-existing ventricular dysfunction?

Output: Hypotension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is worsening HF in patients with pre-existing ventricular dysfunction?. ### Response: Hypotension.


Instruction: What type of pulmonary edema is seen in patients with hypertrophic cardiomyopathy?

Output: worsening HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of pulmonary edema is seen in patients with hypertrophic cardiomyopathy?. ### Response: worsening HF.


Instruction: What is a moderate CYP3A4 inhibitor of Verapamil?

Output: P-glycoprotein

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a moderate CYP3A4 inhibitor of Verapamil?. ### Response: P-glycoprotein.


Instruction: What is the maximum dose of digoxin/kg over 24 h?

Output: 8–12 mcg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the maximum dose of digoxin/kg over 24 h?. ### Response: 8–12 mcg.


Instruction: How long does it take for Digoxin to load a patient?

Output: 0.5 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take for Digoxin to load a patient?. ### Response: 0.5 mg.


Instruction: What is a common cause of heart failure?

Output: pre-existing ventricular dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a common cause of heart failure?. ### Response: pre-existing ventricular dysfunction.


Instruction: How much do drugs with SA and/or AV nodal-blocking properties reduce the dose of?

Output: 30%–50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much do drugs with SA and/or AV nodal-blocking properties reduce the dose of?. ### Response: 30%–50%.


Instruction: How much does amiodarone reduce dose when administered?

Output: 30%–50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much does amiodarone reduce dose when administered?. ### Response: 30%–50%.


Instruction: What does WPW with AF/atrial flutter mean?

Output: Hypotension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does WPW with AF/atrial flutter mean?. ### Response: Hypotension.


Instruction: How much do drugs with SA and/or AV nodal-blocking properties reduce dose?

Output: 30%–50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much do drugs with SA and/or AV nodal-blocking properties reduce dose?. ### Response: 30%–50%.


Instruction: How much does amiodarone reduce dose when administered with dronedarone?

Output: 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much does amiodarone reduce dose when administered with dronedarone?. ### Response: 50%.


Instruction: What should be monitored with verapamil, clarithromycin, itraconazole, cyclosporine, propafenone, flecainide?

Output: digoxin concentrations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be monitored with verapamil, clarithromycin, itraconazole, cyclosporine, propafenone, flecainide?. ### Response: digoxin concentrations.


Instruction: What should be kept below 0.7–1.0 mcg/mL?

Output: trough plasma levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be kept below 0.7–1.0 mcg/mL?. ### Response: trough plasma levels.


Instruction: Sinus or AV conduction disease (in absence of pacemaker)• Cardiogenic shock • Avoid in structural heart disease (including ischemic heart disease)• Brugada syndrome • Renal dysfunction • Hepatic dysfunction • QT-prolonging drugs• Amiodarone, digoxin, ritonavir, saquinavir and tipranavir

Output: Sinus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Sinus or AV conduction disease (in absence of pacemaker)• Cardiogenic shock • Avoid in structural heart disease (including ischemic heart disease)• Brugada syndrome • Renal dysfunction • Hepatic dysfunction • QT-prolonging drugs• Amiodarone, digoxin, ritonavir, saquinavir and tipranavir. ### Response: Sinus.


Instruction: How many mg are given every 12 h (extended release)?

Output: 225

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mg are given every 12 h (extended release)?. ### Response: 225.


Instruction: What is the dose of 300 mg every 8 h for immediate release?

Output: 300 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the dose of 300 mg every 8 h for immediate release?. ### Response: 300 mg.


Instruction: How often should PR and QRS intervals be given?

Output: 425 mg every 12 h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often should PR and QRS intervals be given?. ### Response: 425 mg every 12 h.


Instruction: What are the professional societies' attempts at providing a framework for evaluating the appropriateness of procedures in the cardiac catheterization laboratory?

Output: Revascularization ”(11) and the “ACCF/SCAI/AATS/AHA/ASE/ASNC/HFSA/HRS/SCCM/SCCT/SCMR/STS 2012 Appropriate Use Criteria for Diagnostic Catheter-ization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the professional societies' attempts at providing a framework for evaluating the appropriateness of procedures in the cardiac catheterization laboratory?. ### Response: Revascularization ”(11) and the “ACCF/SCAI/AATS/AHA/ASE/ASNC/HFSA/HRS/SCCM/SCCT/SCMR/STS 2012 Appropriate Use Criteria for Diagnostic Catheter-ization.


Instruction: What did research demonstrate that the indication for revascularizationcan be captured and evaluated for?

Output: appropriateness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did research demonstrate that the indication for revascularizationcan be captured and evaluated for?. ### Response: appropriateness.


Instruction: What can be captured and evaluated for appropriateness?

Output: the indication for revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be captured and evaluated for appropriateness?. ### Response: the indication for revascularization.


Instruction: What is a t e so fi n c o m p l e s ecriteria?

Output: emergency or urgent revascularization forpatients with acute coronary syndromes is generally consideredappropriate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a t e so fi n c o m p l e s ecriteria?. ### Response: emergency or urgent revascularization forpatients with acute coronary syndromes is generally consideredappropriate.


Instruction: What type of revascularization is generally consideredappropriate for patients with acute coronary syndromes?

Output: emergency or urgent revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of revascularization is generally consideredappropriate for patients with acute coronary syndromes?. ### Response: emergency or urgent revascularization.


Instruction: What features should be considered in determiningappropriateness of cases?

Output: symptom status, degree ofischemia, anatomy, and current m e d i c a lt h e r a p y

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What features should be considered in determiningappropriateness of cases?. ### Response: symptom status, degree ofischemia, anatomy, and current m e d i c a lt h e r a p y.


Instruction: How should symptom status, degree ofischemia, anatomy and current m e d i c be considered?

Output: elective revascularization, severalimportant features should be considered in determiningappropriateness of cases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How should symptom status, degree ofischemia, anatomy and current m e d i c be considered?. ### Response: elective revascularization, severalimportant features should be considered in determiningappropriateness of cases.


Instruction: What are central to the data that should be captured as theindication for most revascularization procedures?

Output: T h e s ee l e -ments

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are central to the data that should be captured as theindication for most revascularization procedures?. ### Response: T h e s ee l e -ments.


Instruction: What is the initial goal of measure 1?

Output: comprehensive documentation ofindications for PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the initial goal of measure 1?. ### Response: comprehensive documentation ofindications for PCI.


Instruction: What is the goal of measure 1?

Output: comprehensive documentation ofindications for PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the goal of measure 1?. ### Response: comprehensive documentation ofindications for PCI.


Instruction: What is measure 2?

Output: appropriate indication forelective PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is measure 2?. ### Response: appropriate indication forelective PCI.


Instruction: How is the indication for reva scularization procedures assessed?

Output: appropriateness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the indication for reva scularization procedures assessed?. ### Response: appropriateness.


Instruction: What can be used to improve both the AUC ratings and clinical care?

Output: continued evaluation and feed-back

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be used to improve both the AUC ratings and clinical care?. ### Response: continued evaluation and feed-back.


Instruction: What does the aforementioned factors highlight the dif-ficulty of determining when PCI is clinically indicated?

Output: appropriateness of cases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the aforementioned factors highlight the dif-ficulty of determining when PCI is clinically indicated?. ### Response: appropriateness of cases.


Instruction: What should ideally also address how the decision was made?

Output: performance measurement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should ideally also address how the decision was made?. ### Response: performance measurement.


Instruction: What can play an important role in many cases?

Output: patient preferences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can play an important role in many cases?. ### Response: patient preferences.


Instruction: What is the ideal approach to decision making?

Output: performance measurement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ideal approach to decision making?. ### Response: performance measurement.


Instruction: What does the patient express a strong preference for?

Output: undergo PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the patient express a strong preference for?. ### Response: undergo PCI.


Instruction: What should be reflected as much as possible?

Output: Performance measurement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be reflected as much as possible?. ### Response: Performance measurement.


Instruction: What should physicians' performance measurement ideally be assessed in part by?

Output: surveying patients about whether their input was solicitedand their preferences drove or at least in ﬂuenced thedecision

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should physicians' performance measurement ideally be assessed in part by?. ### Response: surveying patients about whether their input was solicitedand their preferences drove or at least in ﬂuenced thedecision.


Instruction: What should be regarded as givingpatient-centered care?

Output: physicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be regarded as givingpatient-centered care?. ### Response: physicians.


Instruction: What should all patients be?

Output: educated about theiroptions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should all patients be?. ### Response: educated about theiroptions.