Instruction: What is the 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation?

Output: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation?. ### Response: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society.


Instruction: What is a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society?

Output: 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society?. ### Response: 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation.


Instruction: What is the 2019 focus of the AHA/ACC/HRS guideline for the management of pa-tients with atrial fibrillation?

Output: up-date of the 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2019 focus of the AHA/ACC/HRS guideline for the management of pa-tients with atrial fibrillation?. ### Response: up-date of the 2014.


Instruction: What was developed in collaboration with the Society of Heart Rhythm Society?

Output: AHA/ACC/HRS guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was developed in collaboration with the Society of Heart Rhythm Society?. ### Response: AHA/ACC/HRS guideline.


Instruction: Who developed Heart Rhythm Society?

Output: Society of Thoracic Surgeons

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who developed Heart Rhythm Society?. ### Response: Society of Thoracic Surgeons.


Instruction: What is the name of the Society of Thoracic Surgeons collaboration?

Output: American College of Cardiol-ogy/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Society of Thoracic Surgeons collaboration?. ### Response: American College of Cardiol-ogy/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society.


Instruction: How is the intervention for women with Native VHD before and During Pregnancy?

Output: Pre-Pregnancy Intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the intervention for women with Native VHD before and During Pregnancy?. ### Response: Pre-Pregnancy Intervention.


Instruction: What are the outcomes of valvular heart disease in pregnant women?

Output: maternal and fetal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the outcomes of valvular heart disease in pregnant women?. ### Response: maternal and fetal.


Instruction: What is the name of the prospective multicenter study of pregnancy outcomes in women with heart disease?

Output: Siu SC, Sermer M, Colman JM, et al.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective multicenter study of pregnancy outcomes in women with heart disease?. ### Response: Siu SC, Sermer M, Colman JM, et al..


Instruction: What is the effect of valvular heart disease on maternal and fetal outcome of pregnancy?

Output: Clinical and echocar -diographic assessment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of valvular heart disease on maternal and fetal outcome of pregnancy?. ### Response: Clinical and echocar -diographic assessment.


Instruction: What are the prognostic factors of rheumatic mitral stenosis during pregnancy and puerperium?

Output: 4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the prognostic factors of rheumatic mitral stenosis during pregnancy and puerperium?. ### Response: 4.


Instruction: What does pregnancy and puerperium mean?

Output: rheumatic mitral stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does pregnancy and puerperium mean?. ### Response: rheumatic mitral stenosis.


Instruction: What is the name of the registry that shows the risk of pregnancy in moderate and severe aortic stenosis?

Output: ROPAC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the registry that shows the risk of pregnancy in moderate and severe aortic stenosis?. ### Response: ROPAC.


Instruction: Who is the author of Cardiac disease in pregnancy?

Output: Bhatla N, Lal S, Behera G

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of Cardiac disease in pregnancy?. ### Response: Bhatla N, Lal S, Behera G.


Instruction: What type of aortic stenosis is from the multinational ROPAC registry?

Output: moderate and severe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of aortic stenosis is from the multinational ROPAC registry?. ### Response: moderate and severe.


Instruction: What is the J Am Coll Cardiol. 2016:68:1727–37?

Output: Risk of pregnancy in moderate and severe aortic stenosis: from the multinational ROPAC registry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the J Am Coll Cardiol. 2016:68:1727–37?. ### Response: Risk of pregnancy in moderate and severe aortic stenosis: from the multinational ROPAC registry.


Instruction: Who is the author of Late cardiac outcomes af-ter pregnancy in women with congenital Aortic Stenosis?

Output: Tzemos N, Silversides CK, Colman JM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of Late cardiac outcomes af-ter pregnancy in women with congenital Aortic Stenosis?. ### Response: Tzemos N, Silversides CK, Colman JM.


Instruction: What is aortic stenosis and pregnancy?

Output: Risk of pregnancy in moderate and severe aortic stenosis: from the multinational ROPAC registry. J Am Coll Cardiol. 2016;68:1727–37. 7. Tzemos N, Silversides CK, Colman JM, et al. Late cardiac outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is aortic stenosis and pregnancy?. ### Response: Risk of pregnancy in moderate and severe aortic stenosis: from the multinational ROPAC registry. J Am Coll Cardiol. 2016;68:1727–37. 7. Tzemos N, Silversides CK, Colman JM, et al. Late cardiac outcomes.


Instruction: What is the J Reprod Med. 1978:229–32?

Output: Aortic stenosis and pregnancy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the J Reprod Med. 1978:229–32?. ### Response: Aortic stenosis and pregnancy.


Instruction: Who is Silversides CK, Colman JM, Sermer M?

Output: Siu SC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Silversides CK, Colman JM, Sermer M?. ### Response: Siu SC.


Instruction: What is the risk of complications dur -ing pregnancy in women with congenital aortic stenosis?

Output: Late cardiac outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of complications dur -ing pregnancy in women with congenital aortic stenosis?. ### Response: Late cardiac outcomes.


Instruction: Int J Cardiol. 2008;126:240–6.

Output: Risk of complications dur -ing pregnancy in women with congenital aortic stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Int J Cardiol. 2008;126:240–6.. ### Response: Risk of complications dur -ing pregnancy in women with congenital aortic stenosis.


Instruction: What is used for prognostic evaluation of patients with known or suspected coronaryartery disease?

Output: exercise echocardiog-raphy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used for prognostic evaluation of patients with known or suspected coronaryartery disease?. ### Response: exercise echocardiog-raphy.


Instruction: When did J Am Coll Cardiol. 1997;30:83–90.361?

Output: 1997

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J Am Coll Cardiol. 1997;30:83–90.361?. ### Response: 1997.


Instruction: What did Morrow K, Morris CK, Froelicher VF, et al. do?

Output: Prediction of cardiovas-cular death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Morrow K, Morris CK, Froelicher VF, et al. do?. ### Response: Prediction of cardiovas-cular death.


Instruction: What is the name of the noninvasive evaluation of men for coronaryartery disease?

Output: Prediction of cardiovas-cular death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the noninvasive evaluation of men for coronaryartery disease?. ### Response: Prediction of cardiovas-cular death.


Instruction: What is exercise technetium-99m sestamibi tomography for?

Output: cardiac risk stratification of patientswith stable chest pain

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is exercise technetium-99m sestamibi tomography for?. ### Response: cardiac risk stratification of patientswith stable chest pain.


Instruction: What is the difference between revascularization and medical therapy?

Output: Impaired left ventricularfunction, one- or two-vessel coronary artery disease, and severe ische-mia: outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between revascularization and medical therapy?. ### Response: Impaired left ventricularfunction, one- or two-vessel coronary artery disease, and severe ische-mia: outcome.


Instruction: What is CASS?

Output: a randomized trial of coronaryartery bypass surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CASS?. ### Response: a randomized trial of coronaryartery bypass surgery.


Instruction: How long does CASS last?

Output: Long-term survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does CASS last?. ### Response: Long-term survival.


Instruction: What is the acronym for the Coronary Artery Surgery Study?

Output: CASS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the Coronary Artery Surgery Study?. ### Response: CASS.


Instruction: When was the Circulation 90:2645-57.365 published?

Output: 1994

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circulation 90:2645-57.365 published?. ### Response: 1994.


Instruction: What was the name of the study that investigated the results of coronary artery surgery in patients with poor left ventricular function?

Output: Coronary Artery Surgery Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the study that investigated the results of coronary artery surgery in patients with poor left ventricular function?. ### Response: Coronary Artery Surgery Study.


Instruction: What is the name of the randomized trial of coronary artery bypass surgery?

Output: CASS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized trial of coronary artery bypass surgery?. ### Response: CASS.


Instruction: How many patients were randomly assigned totreatment groups in the CASS study?

Output: Eleven-year survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were randomly assigned totreatment groups in the CASS study?. ### Response: Eleven-year survival.


Instruction: What is another name for CASS?

Output: Coronary ArterySurgery Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for CASS?. ### Response: Coronary ArterySurgery Study.


Instruction: In what year did Circulation issue 68?

Output: 1983

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did Circulation issue 68?. ### Response: 1983.


Instruction: What does BARI stand for?

Output: Bypass Angioplasty RevascularizationInvestigation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does BARI stand for?. ### Response: Bypass Angioplasty RevascularizationInvestigation.


Instruction: What is the name of the BARI Investigators?

Output: Bypass Angioplasty RevascularizationInvestigation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the BARI Investigators?. ### Response: Bypass Angioplasty RevascularizationInvestigation.


Instruction: When did BARI begin?

Output: 1996

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did BARI begin?. ### Response: 1996.


Instruction: What is angiographicprogression of coronary artery disease and the development of myo-cardial infarction?

Output: revascularization procedures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is angiographicprogression of coronary artery disease and the development of myo-cardial infarction?. ### Response: revascularization procedures.


Instruction: What is the J Am Coll Cardiol. 1988:12:56–62.371.

Output: Angiographicprogression of coronary artery disease and the development of myo-cardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the J Am Coll Cardiol. 1988:12:56–62.371.. ### Response: Angiographicprogression of coronary artery disease and the development of myo-cardial infarction.


Instruction: What can coronaryangiography predict the site of?

Output: a subsequent myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can coronaryangiography predict the site of?. ### Response: a subsequent myocardial infarction.


Instruction: How long did the Veterans Administration randomized trial of coronary bypass surgery for stable angina last?

Output: Eleven-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the Veterans Administration randomized trial of coronary bypass surgery for stable angina last?. ### Response: Eleven-year.


Instruction: What is the name of the randomized study that randomized patients to undergo coronary artery bypass surgery?

Output: CASS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized study that randomized patients to undergo coronary artery bypass surgery?. ### Response: CASS.


Instruction: How long was the survival rate in the vs. Adminis-tration trial?

Output: Eleven-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the survival rate in the vs. Adminis-tration trial?. ### Response: Eleven-year.


Instruction: What is the Veterans Adminis-tration Coronary Artery Bypass Surgery Cooperative Study Group?

Output: Eleven-year survival in the Veterans Administration randomized trialof coronary bypass surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Veterans Adminis-tration Coronary Artery Bypass Surgery Cooperative Study Group?. ### Response: Eleven-year survival in the Veterans Administration randomized trialof coronary bypass surgery.


Instruction: When was the N Engl J Med 311:1333–9.374?

Output: 1984

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the N Engl J Med 311:1333–9.374?. ### Response: 1984.


Instruction: What study did Ringqvist I, Fisher LD, Mock M, et al. conduct?

Output: Coronary ArterySurgery Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What study did Ringqvist I, Fisher LD, Mock M, et al. conduct?. ### Response: Coronary ArterySurgery Study.


Instruction: What year did Invest.71:1854–66.375?

Output: 1983

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Invest.71:1854–66.375?. ### Response: 1983.


Instruction: What is the name of the study that followed Invest?

Output: Bypass Angioplasty RevascularizationInvestigation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that followed Invest?. ### Response: Bypass Angioplasty RevascularizationInvestigation.


Instruction: What is the BP at 180/105mm Hg during and for 24 hours after a mechanical thrombectomy?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the BP at 180/105mm Hg during and for 24 hours after a mechanical thrombectomy?. ### Response: ≤.


Instruction: How long after the procedure is it reasonable to maintain BP?

Output: 24 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after the procedure is it reasonable to maintain BP?. ### Response: 24 hours.


Instruction: What is a B-NRNew recommendation?

Output: II

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a B-NRNew recommendation?. ### Response: II.


Instruction: What should BP be maintained at in patients who undergo mechanical thrombectomy with successful reperfusion?

Output: SBP <140 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should BP be maintained at in patients who undergo mechanical thrombectomy with successful reperfusion?. ### Response: SBP <140 mm Hg.


Instruction: What is very limited data to guide BP management during and after the procedure?

Output: RCT data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is very limited data to guide BP management during and after the procedure?. ### Response: RCT data.


Instruction: What is not available in RCTs in mechanical thrombectomy?

Output: RCT data on optimal BP management approaches

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not available in RCTs in mechanical thrombectomy?. ### Response: RCT data on optimal BP management approaches.


Instruction: What did the vast majority of patients enrolled in 6-hour RCT receive?

Output: IV alteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the vast majority of patients enrolled in 6-hour RCT receive?. ### Response: IV alteplase.


Instruction: How long did the trial protocols stipulate BP?

Output: 24 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the trial protocols stipulate BP?. ### Response: 24 hours.


Instruction: What was the local guidelines for BP 180/105 during and for 24 hours after the procedure for these participants?

Output: ≤180/105

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the local guidelines for BP 180/105 during and for 24 hours after the procedure for these participants?. ### Response: ≤180/105.


Instruction: How many trial protocols provided additional recommendations?

Output: Two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many trial protocols provided additional recommendations?. ### Response: Two.


Instruction: What is probably useful in promoting and keeping collateral flow adequate while the artery remains occluded?

Output: SBP ≥150 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is probably useful in promoting and keeping collateral flow adequate while the artery remains occluded?. ### Response: SBP ≥150 mm Hg.


Instruction: What is an IV -blocker such as metoprolol in low doses?

Output: Labetalol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an IV -blocker such as metoprolol in low doses?. ### Response: Labetalol.


Instruction: What protocol recommends maintaining SBP 140 mm Hg in the DAWN protocol?

Output: DAWN

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What protocol recommends maintaining SBP 140 mm Hg in the DAWN protocol?. ### Response: DAWN.


Instruction: DAWN protocol recommends maintaining SBP 140 mm Hg in the first 24 hours in subjects who are reperfused after what?

Output: mechanical thrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: DAWN protocol recommends maintaining SBP 140 mm Hg in the first 24 hours in subjects who are reperfused after what?. ### Response: mechanical thrombectomy.


Instruction: What is defined as achieving more than two-thirds MCA territory reperfusion?

Output: mechanical thrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is defined as achieving more than two-thirds MCA territory reperfusion?. ### Response: mechanical thrombectomy.


Instruction: What type of thrombectomy is recommended over intra-arterial fibrinolysis?

Output: Mechanical

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of thrombectomy is recommended over intra-arterial fibrinolysis?. ### Response: Mechanical.


Instruction: What year was the C-EORecommendation reworded for clarity?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the C-EORecommendation reworded for clarity?. ### Response: 2015.


Instruction: How long after stroke is intra-arterial fibrinolysis initiated in carefully selected patients?

Output: 6 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after stroke is intra-arterial fibrinolysis initiated in carefully selected patients?. ### Response: 6 hours.


Instruction: What is the original wording of Table XCV?

Output: New, Revised, or Unchanged

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the original wording of Table XCV?. ### Response: New, Revised, or Unchanged.


Instruction: What might patients who have contraindications to the use of IV alteplase might be considered?

Output: Intra-arterial fibrinolysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What might patients who have contraindications to the use of IV alteplase might be considered?. ### Response: Intra-arterial fibrinolysis.


Instruction: What was reworded for clarity from 2015 Endovascular?

Output: C-EORecommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was reworded for clarity from 2015 Endovascular?. ### Response: C-EORecommendation.


Instruction: LOE amended to conform with what system?

Output: ACC/AHA 2015 Recommendation Classification System

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: LOE amended to conform with what system?. ### Response: ACC/AHA 2015 Recommendation Classification System.


Instruction: Online Data Supplement 1 for original wording?

Output: Table XCV

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Online Data Supplement 1 for original wording?. ### Response: Table XCV.


Instruction: Antiplatelet Treatment What is another name for antiplatelet treatment?

Output: COR LOE New, Revised, or Unchanged

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Antiplatelet Treatment What is another name for antiplatelet treatment?. ### Response: COR LOE New, Revised, or Unchanged.


Instruction: What is the name of the online data supplement?

Output: 1.3.8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the online data supplement?. ### Response: 1.3.8.


Instruction: What has been shown to be superior to lidocaine for terminating the arrhythmia in patients with recurrent, stable VT not in the setting of an AMI?

Output: procainamide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been shown to be superior to lidocaine for terminating the arrhythmia in patients with recurrent, stable VT not in the setting of an AMI?. ### Response: procainamide.


Instruction: What is lidocaine used for?

Output: terminating the arrhythmia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is lidocaine used for?. ### Response: terminating the arrhythmia.


Instruction: How many patients found procainamide superior to amiodarone for termination of stable VT?

Output: 62

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients found procainamide superior to amiodarone for termination of stable VT?. ### Response: 62.


Instruction: Adverse events, including hypotension, were more common with what drug?

Output: amiodarone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Adverse events, including hypotension, were more common with what drug?. ### Response: amiodarone.


Instruction: What is n-acetylprocainamide's metabolite called?

Output: Procainamide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is n-acetylprocainamide's metabolite called?. ### Response: Procainamide.


Instruction: What is the QT interval blocked by?

Output: potassium channel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the QT interval blocked by?. ### Response: potassium channel.


Instruction: How many patients were compared in a single RCT with sotalol?

Output: 33

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were compared in a single RCT with sotalol?. ### Response: 33.


Instruction: How many patients were compared with sotalol for treating hemodynami-cally stable VT?

Output: 69%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were compared with sotalol for treating hemodynami-cally stable VT?. ### Response: 69%.


Instruction: What percentage of patients were treated with lidocaine?

Output: 18%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients were treated with lidocaine?. ### Response: 18%.


Instruction: How much of the patients who treated VT had VT terminated using sotalal?

Output: 69%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the patients who treated VT had VT terminated using sotalal?. ### Response: 69%.


Instruction: Which drug has been approved for use in the United States?

Output: S6-25 Intravenous sotalol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which drug has been approved for use in the United States?. ### Response: S6-25 Intravenous sotalol.


Instruction: Sotalol has potassium channel blocking properties that may prolong what?

Output: QT interval

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Sotalol has potassium channel blocking properties that may prolong what?. ### Response: QT interval.


Instruction: What may further prolong the QT interval and lead to torsades de pointes?

Output: administration of sotalol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may further prolong the QT interval and lead to torsades de pointes?. ### Response: administration of sotalol.


Instruction: What color corresponds to Class of Recommendation in Table 1?

Output: S6-25Figure 2. Management of sustained monomorphic VT. Colors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What color corresponds to Class of Recommendation in Table 1?. ### Response: S6-25Figure 2. Management of sustained monomorphic VT. Colors.


Instruction: What indicates advanced cardiovascular life support?

Output: ACLS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates advanced cardiovascular life support?. ### Response: ACLS.


Instruction: What is a TRITON-TIMI 38 study?

Output: Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel-Thrombolysis In Myocardial Infarction 38

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a TRITON-TIMI 38 study?. ### Response: Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel-Thrombolysis In Myocardial Infarction 38.


Instruction: What is the name of the study that evaluated the safety of prasugrel with and without an inhibi-tor?

Output: TRITON-TIMI 38

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated the safety of prasugrel with and without an inhibi-tor?. ### Response: TRITON-TIMI 38.


Instruction: What is the difference between bivalirudin and unfractionated heparin among patients undergoing coronary angioplasty?

Output: Bivalirudin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between bivalirudin and unfractionated heparin among patients undergoing coronary angioplasty?. ### Response: Bivalirudin.


Instruction: What is a meta-analyis of randomised trials?

Output: Bivalirudin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a meta-analyis of randomised trials?. ### Response: Bivalirudin.


Instruction: What did Lincoff AM, Bittl JA, Harrington RA, et al. compare with heparin and bivalirudin during percutaneous coronary intervention?

Output: Biva lirudin and provisional glycoprotein IIb/IIIa blockade

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Lincoff AM, Bittl JA, Harrington RA, et al. compare with heparin and bivalirudin during percutaneous coronary intervention?. ### Response: Biva lirudin and provisional glycoprotein IIb/IIIa blockade.


Instruction: What was the name of the Randomized Evaluation of PCI Linking Angiomax to Reduced Clinical Events?

Output: REPLACE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the Randomized Evaluation of PCI Linking Angiomax to Reduced Clinical Events?. ### Response: REPLACE.


Instruction: What is lirudin and provisional glycoprotein IIb/IIIa blockade compared with?

Output: heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is lirudin and provisional glycoprotein IIb/IIIa blockade compared with?. ### Response: heparin.


Instruction: What was the REPLACE-2 randomized trial?

Output: Biva lirudin and provisional glycoprotein IIb/IIIa blockade compared with heparin and planned gly-coprotein IIb/IIIa blockade during percutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the REPLACE-2 randomized trial?. ### Response: Biva lirudin and provisional glycoprotein IIb/IIIa blockade compared with heparin and planned gly-coprotein IIb/IIIa blockade during percutaneous coronary intervention.


Instruction: When did JAMA issue 289:853-63?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did JAMA issue 289:853-63?. ### Response: 2003.


Instruction: How did Kastrati A compare to heparin?

Output: Bivalirudin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Kastrati A compare to heparin?. ### Response: Bivalirudin.


Instruction: What is enoxaparin 0.3 mg/kg IV sup-plement for patients transitioning to PCI after?

Output: subcutaneous enoxaparin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is enoxaparin 0.3 mg/kg IV sup-plement for patients transitioning to PCI after?. ### Response: subcutaneous enoxaparin therapy.


Instruction: What is bivalirudin dur ing primary PCI in acute myocardial infarction?

Output: intravenous unfractionated heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is bivalirudin dur ing primary PCI in acute myocardial infarction?. ### Response: intravenous unfractionated heparin.


Instruction: What is a subgroup analysis from the SYNERGY trial?

Output: Enoxaparin 0.3 mg/kg IV sup-plement for patients transitioning to PCI after subcutaneous enoxaparin therapy for NSTE ACS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a subgroup analysis from the SYNERGY trial?. ### Response: Enoxaparin 0.3 mg/kg IV sup-plement for patients transitioning to PCI after subcutaneous enoxaparin therapy for NSTE ACS.


Instruction: What is the name of the study that evaluated IV sup-plement for patients transitioning to PCI after subcutaneous enoxaparin therapy?

Output: SYNERGY trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated IV sup-plement for patients transitioning to PCI after subcutaneous enoxaparin therapy?. ### Response: SYNERGY trial.


Instruction: What is enoxaparin used for in patients with acute coronary syndromes?

Output: early invasive strategy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is enoxaparin used for in patients with acute coronary syndromes?. ### Response: early invasive strategy.


Instruction: What is the name of the drug used to treat unstable angina pectoris?

Output: enoxaparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used to treat unstable angina pectoris?. ### Response: enoxaparin.


Instruction: In what year did Circulation issue 103:658-63?

Output: 2001

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did Circulation issue 103:658-63?. ### Response: 2001.


Instruction: What is the name of the pharmacokinetics of enoxaparin in PCI study?

Output: SYNERGY trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the pharmacokinetics of enoxaparin in PCI study?. ### Response: SYNERGY trial.


Instruction: When was the Catheter Cardiovasc Interv. 61:163-70?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Catheter Cardiovasc Interv. 61:163-70?. ### Response: 2004.


Instruction: What was the degree of anticoagulation after one subcutaneous and one subsequent intravenous booster dose?

Output: 403

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the degree of anticoagulation after one subcutaneous and one subsequent intravenous booster dose?. ### Response: 403.


Instruction: What does enoxaparin have for patients with acute coronary syndromes undergoing early percutaneous coronary intervention?

Output: early invasive strategy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does enoxaparin have for patients with acute coronary syndromes undergoing early percutaneous coronary intervention?. ### Response: early invasive strategy.


Instruction: When was the J Thromb Thrombolysis 17:167–71 published?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Thromb Thrombolysis 17:167–71 published?. ### Response: 2004.


Instruction: What is the name of the randomized trial of Fondaparainux with UnfracTionated hep-arin dUring Revascularization in Acute coronary Syndromes?

Output: FUTURA/OASIS 8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized trial of Fondaparainux with UnfracTionated hep-arin dUring Revascularization in Acute coronary Syndromes?. ### Response: FUTURA/OASIS 8.


Instruction: What is a randomized trial of intravenous unfractionated heparin dur -ing percutaneous coronary intervention in patients with non-ST-segment elevation acute coronary syndromes?

Output: Fondaparinux with UnfracTionated hep-arin dUring Revascularization in Acute coronary syndromes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a randomized trial of intravenous unfractionated heparin dur -ing percutaneous coronary intervention in patients with non-ST-segment elevation acute coronary syndromes?. ### Response: Fondaparinux with UnfracTionated hep-arin dUring Revascularization in Acute coronary syndromes.


Instruction: What was initially treated with fondaparinux?

Output: patients with non-ST-segment elevation acute coronary syndromes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was initially treated with fondaparinux?. ### Response: patients with non-ST-segment elevation acute coronary syndromes.


Instruction: What is the name of the ERACI group?

Output: ERACI Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the ERACI group?. ### Response: ERACI Group.


Instruction: How long did the follow-up of the Argentina randomized trial of percutaneous transluminal coronaryangioplasty versus coronary artery bypass surgery last?

Output: 1-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the follow-up of the Argentina randomized trial of percutaneous transluminal coronaryangioplasty versus coronary artery bypass surgery last?. ### Response: 1-year.


Instruction: What is ERACI?

Output: lasty Versus Coronary Artery Bypass Surgery in Multi-vesselDisease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ERACI?. ### Response: lasty Versus Coronary Artery Bypass Surgery in Multi-vesselDisease.


Instruction: What is CABRI?

Output: Coronary Angioplasty versus BypassRevascularization investigation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CABRI?. ### Response: Coronary Angioplasty versus BypassRevascularization investigation.


Instruction: What is the name of the CABRI trial?

Output: Coronary Angioplasty versus BypassRevascularization investigation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the CABRI trial?. ### Response: Coronary Angioplasty versus BypassRevascularization investigation.


Instruction: When did the Eur Heart J issue 20:653–8.143?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the Eur Heart J issue 20:653–8.143?. ### Response: 1999.


Instruction: What is a ran-domised controlled trial of the Stent or Surgery trial in patients with multivessel coronary artery disease?

Output: theSIMA trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a ran-domised controlled trial of the Stent or Surgery trial in patients with multivessel coronary artery disease?. ### Response: theSIMA trial.


Instruction: What is the difference between primary directstenting and MIDCAB?

Output: preliminary report-comparision of twomethods of revascularization in single left anterior descending coronaryartery stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between primary directstenting and MIDCAB?. ### Response: preliminary report-comparision of twomethods of revascularization in single left anterior descending coronaryartery stenosis.


Instruction: What are the two methods of revascularization in single left anterior descending coronaryartery stenosis?

Output: Primarystenting versus MIDCAB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the two methods of revascularization in single left anterior descending coronaryartery stenosis?. ### Response: Primarystenting versus MIDCAB.


Instruction: What type of surgery is used in patients with proximal stenosis of the left anterior descending coronaryartery?

Output: off-pump coronary surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of surgery is used in patients with proximal stenosis of the left anterior descending coronaryartery?. ### Response: off-pump coronary surgery.


Instruction: What is the purpose of endoscopic atraumatic coronary artery bypass surgery?

Output: high-grade ste-nosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of endoscopic atraumatic coronary artery bypass surgery?. ### Response: high-grade ste-nosis.


Instruction: What is the name of the proximal left anterior descending coronary artery?

Output: MIDCAB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the proximal left anterior descending coronary artery?. ### Response: MIDCAB.


Instruction: What type of surgery is used to treat high-grade ste-nosis?

Output: off-pump coronary surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of surgery is used to treat high-grade ste-nosis?. ### Response: off-pump coronary surgery.


Instruction: When was the follow-up period of stenting and off-pump coronary surgery?

Output: three-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the follow-up period of stenting and off-pump coronary surgery?. ### Response: three-year.


Instruction: How long did it take for a patient to recover from a percutaneous transluminal angioplasty procedure?

Output: four years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for a patient to recover from a percutaneous transluminal angioplasty procedure?. ### Response: four years.


Instruction: What is the difference between off-pump left internal mammary artery bypass grafting and percutaneous surgery?

Output: functional health status

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between off-pump left internal mammary artery bypass grafting and percutaneous surgery?. ### Response: functional health status.


Instruction: When was the last year of the Am Coll Cardiol?

Output: 1955

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last year of the Am Coll Cardiol?. ### Response: 1955.


Instruction: What is the name of the prospective trial that compares stenting to internal mammary artery grafting for proximal, isolated de novo?

Output: theSIMA trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective trial that compares stenting to internal mammary artery grafting for proximal, isolated de novo?. ### Response: theSIMA trial.


Instruction: What is stenting to internal mammary artery grafting for?

Output: proximal, isolated de novo left anterior coronary artery stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is stenting to internal mammary artery grafting for?. ### Response: proximal, isolated de novo left anterior coronary artery stenosis.


Instruction: What is theSIMA trial?

Output: A prospective ran-domized trial comparing stenting to internal mammary artery grafting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is theSIMA trial?. ### Response: A prospective ran-domized trial comparing stenting to internal mammary artery grafting.


Instruction: Stenting vs Internal Mammary Artery. Mayo Clin Proc.2000;75:1116–23.151.

Output: theSIMA trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Stenting vs Internal Mammary Artery. Mayo Clin Proc.2000;75:1116–23.151.. ### Response: theSIMA trial.


Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?

Output: Otto et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2020 ACC/AHA Guideline for the Management of Valvular Heart Disease?. ### Response: Otto et al.


Instruction: What is the name of the guideline that will be published in 2021?

Output: ACC/AHA Guideline for the Management of Valvular Heart Disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the guideline that will be published in 2021?. ### Response: ACC/AHA Guideline for the Management of Valvular Heart Disease.


Instruction: What is the Loire Valley Atrial Fibrillation Project?

Output: Oral anticoagulation, stroke and thromboembolism in patients with atrial fibrillation and valve bioprosthesis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Loire Valley Atrial Fibrillation Project?. ### Response: Oral anticoagulation, stroke and thromboembolism in patients with atrial fibrillation and valve bioprosthesis.


Instruction: When was the DAWA Pilot Study conducted?

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the DAWA Pilot Study conducted?. ### Response: 2016.


Instruction: How many patients were treated with Dabigatran and Warfarin?

Output: 20

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with Dabigatran and Warfarin?. ### Response: 20.


Instruction: Atrial Fibrillation Postoperatively: DAWA Pilot Study. Drugs R D. 2016;16:149–54.

Output: 20

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atrial Fibrillation Postoperatively: DAWA Pilot Study. Drugs R D. 2016;16:149–54.. ### Response: 20.


Instruction: Non-vitamin K antagonist oral anticoagulants versus warfarin in patients with atrial fibrillation and valvular heart disease.

Output: Comparative effectiveness and safety

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Non-vitamin K antagonist oral anticoagulants versus warfarin in patients with atrial fibrillation and valvular heart disease.. ### Response: Comparative effectiveness and safety.


Instruction: Int J Cardiol 2016;209:181–3.

Output: atrial fibrillation and valvular heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Int J Cardiol 2016;209:181–3.. ### Response: atrial fibrillation and valvular heart disease.


Instruction: Int J Cardiol. 2016;209:181–3. 22. Kim JY, Kim S-H, Myong J-P, et al. Outcomes of direct oral anticoagulants in patients with mitral stenosis.

Output: atrial fibrillation and valvular heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Int J Cardiol. 2016;209:181–3. 22. Kim JY, Kim S-H, Myong J-P, et al. Outcomes of direct oral anticoagulants in patients with mitral stenosis.. ### Response: atrial fibrillation and valvular heart disease.


Instruction: What is rivaroxaban af-ter transcatheter aortic-valve replacement?

Output: Dabigatran Versus Warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is rivaroxaban af-ter transcatheter aortic-valve replacement?. ### Response: Dabigatran Versus Warfarin.


Instruction: What is Edwards FH, Cohen DJ, O’Brien SM, et al. developing and validation of a risk prediction model for in-hospital mortality?

Output: transcatheter aortic valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Edwards FH, Cohen DJ, O’Brien SM, et al. developing and validation of a risk prediction model for in-hospital mortality?. ### Response: transcatheter aortic valve replacement.


Instruction: What is the name of the registry model used to predict mortality after a transcatheter aortic valve replacement?

Output: Transcatheter Valve Therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the registry model used to predict mortality after a transcatheter aortic valve replacement?. ### Response: Transcatheter Valve Therapy.


Instruction: What year was the JAMA Cardiol. 1:46–52?

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the JAMA Cardiol. 1:46–52?. ### Response: 2016.


Instruction: How long does it take for a patient to die after a transcatheter aortic valve replacement?

Output: 1-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take for a patient to die after a transcatheter aortic valve replacement?. ### Response: 1-year.


Instruction: What is the name of the new scoring system used in the TAVI risk scoring system?

Output: STS/ACC model

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the new scoring system used in the TAVI risk scoring system?. ### Response: STS/ACC model.


Instruction: Who is the author of the study?

Output: Edwards FH, Cohen DJ, O’Brien SM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of the study?. ### Response: Edwards FH, Cohen DJ, O’Brien SM.


Instruction: What is a risk score to predict after transcatheter aortic valve replacement?

Output: new pacemaker implantation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk score to predict after transcatheter aortic valve replacement?. ### Response: new pacemaker implantation.


Instruction: What is the JACC Cardiovasc Interv 2019;12:2133-42?

Output: Development of a risk score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the JACC Cardiovasc Interv 2019;12:2133-42?. ### Response: Development of a risk score.


Instruction: What is a risk prediction model for in-hospital stroke after transcatheter aortic valve replacement?

Output: Development and application of a risk prediction model for in-hospital stroke after transcatheter aortic valve replacement: a report from the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk prediction model for in-hospital stroke after transcatheter aortic valve replacement?. ### Response: Development and application of a risk prediction model for in-hospital stroke after transcatheter aortic valve replacement: a report from the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.


Instruction: What is the Society of Thoracic Surgeons/American College of Cardiology report on?

Output: Transcatheter Valve Therapy Registry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Society of Thoracic Surgeons/American College of Cardiology report on?. ### Response: Transcatheter Valve Therapy Registry.


Instruction: What is the impact of frailty on functional survival in patients 1 year after cardiac surgery?

Output: func-tional survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the impact of frailty on functional survival in patients 1 year after cardiac surgery?. ### Response: func-tional survival.


Instruction: What was the J Thorac Cardiovasc Surg. 2017;154:1990–9?

Output: The impact of frailty on func-tional survival in patients 1 year after cardiac surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the J Thorac Cardiovasc Surg. 2017;154:1990–9?. ### Response: The impact of frailty on func-tional survival in patients 1 year after cardiac surgery.


Instruction: Afilalo J, Alexander KP, MackMJ, et al. Frailtiness assessment in the cardiovascular care of older adults.

Output: 8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Afilalo J, Alexander KP, MackMJ, et al. Frailtiness assessment in the cardiovascular care of older adults.. ### Response: 8.


Instruction: J Am Coll Cardiol. 2014;63:747–62

Output: 8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: J Am Coll Cardiol. 2014;63:747–62. ### Response: 8.


Instruction: What does J Am Coll Cardiol. 2014;63:747–62?

Output: Frailty assessment in the cardiovas-cular care of older adults

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does J Am Coll Cardiol. 2014;63:747–62?. ### Response: Frailty assessment in the cardiovas-cular care of older adults.


Instruction: What does Schoenenberger AW, Moser A, Bertschi D, et al. do?

Output: Improvement of risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Schoenenberger AW, Moser A, Bertschi D, et al. do?. ### Response: Improvement of risk.


Instruction: What should history and physical examination find-ings be correlated with?

Output: the results of noninvasive testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should history and physical examination find-ings be correlated with?. ### Response: the results of noninvasive testing.


Instruction: ECG, chest x-ray, trans-thoracic echocardiogram are examples of what?

Output: noninvasive testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ECG, chest x-ray, trans-thoracic echocardiogram are examples of what?. ### Response: noninvasive testing.


Instruction: What should be considered if there is discordance between physical examination and noninvasive testing?

Output: further noninva-sive (computed tomography, cardiac magnetic resonance imaging, stress testing) or invasive (transesophageal echocardiography, cardiac catheterization) testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered if there is discordance between physical examination and noninvasive testing?. ### Response: further noninva-sive (computed tomography, cardiac magnetic resonance imaging, stress testing) or invasive (transesophageal echocardiography, cardiac catheterization) testing.


Instruction: What type of testing is considered to determine optimal treatment strategy?

Output: exercise testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of testing is considered to determine optimal treatment strategy?. ### Response: exercise testing.


Instruction: What types of testing are considered invasive or noninvasive?

Output: noninva-sive (computed tomography, cardiac magnetic resonance imaging, stress testing) or invasive (transesophageal echocardiography, cardiac catheterization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What types of testing are considered invasive or noninvasive?. ### Response: noninva-sive (computed tomography, cardiac magnetic resonance imaging, stress testing) or invasive (transesophageal echocardiography, cardiac catheterization.


Instruction: What should patients with rheumatic mitral stenosis or a mechanical prosthesis use to prevent thromboembolic events?

Output: oral anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients with rheumatic mitral stenosis or a mechanical prosthesis use to prevent thromboembolic events?. ### Response: oral anticoagulation.


Instruction: What should be made in a shared decision-making process based on?

Output: CHA2DS2-VASc score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be made in a shared decision-making process based on?. ### Response: CHA2DS2-VASc score.


Instruction: What should patients with rheumatic mitral stenosis or a mechanical prosthesis and atrial fibrillation receive?

Output: oral anticoagulation with a vitamin K antagonist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients with rheumatic mitral stenosis or a mechanical prosthesis and atrial fibrillation receive?. ### Response: oral anticoagulation with a vitamin K antagonist.


Instruction: What should all patients with severe valvular heart disease be evaluated by?

Output: a multidisciplinary team

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should all patients with severe valvular heart disease be evaluated by?. ### Response: a multidisciplinary team.


Instruction: What type of team evaluates severe aortic stenosis?

Output: shared decision-making process

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of team evaluates severe aortic stenosis?. ### Response: shared decision-making process.


Instruction: What should be based primarily on symptoms or reduced ventricular systolic function?

Output: Treatment of severe aortic stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be based primarily on symptoms or reduced ventricular systolic function?. ### Response: Treatment of severe aortic stenosis.


Instruction: What function is indicated by results of exercise testing, biomarkers, rapid progression, or the presence of very severe stenosis?

Output: Earlier intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What function is indicated by results of exercise testing, biomarkers, rapid progression, or the presence of very severe stenosis?. ### Response: Earlier intervention.


Instruction: Indications for transcatheter aortic valve implan-tation are expanding as a result of multiple randomized trials of what?

Output: transcatheter aortic valve implantation versus surgical aortic valve replace-ment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Indications for transcatheter aortic valve implan-tation are expanding as a result of multiple randomized trials of what?. ### Response: transcatheter aortic valve implantation versus surgical aortic valve replace-ment.


Instruction: What is the difference between transcatheter versus surgical aortic valve replace-ment?

Output: reduced ven-tricular systolic function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between transcatheter versus surgical aortic valve replace-ment?. ### Response: reduced ven-tricular systolic function.


Instruction: What should be a shared decision-making process that considers the lifetime risks and benefits associated with type of valve?

Output: The choice of type of intervention for a patient with severe aortic stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be a shared decision-making process that considers the lifetime risks and benefits associated with type of valve?. ### Response: The choice of type of intervention for a patient with severe aortic stenosis.


Instruction: What are the two types of approach for valvular regurgitation?

Output: transcatheter versus surgical

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the two types of approach for valvular regurgitation?. ### Response: transcatheter versus surgical.


Instruction: What are two reasons for lower thresholds for intervention?

Output: more durable treatment options and lower procedural risks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are two reasons for lower thresholds for intervention?. ### Response: more durable treatment options and lower procedural risks.


Instruction: Why are thresholds for inter vention lower than they were previously?

Output: more durable treatment options and lower procedural risks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why are thresholds for inter vention lower than they were previously?. ### Response: more durable treatment options and lower procedural risks.


Instruction: What is a benefit of a mitral transcatheter edge-to-edge repair to patients with primary mitral regurgitation who are at high or prohibitive risk for surgery?

Output: severely symptomatic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a benefit of a mitral transcatheter edge-to-edge repair to patients with primary mitral regurgitation who are at high or prohibitive risk for surgery?. ### Response: severely symptomatic.


Instruction: What subset of patients with secondary mitral regurgitation remain severely symptomatic despite guideline-directed management and therapy for heart failure?

Output: select subset

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What subset of patients with secondary mitral regurgitation remain severely symptomatic despite guideline-directed management and therapy for heart failure?. ### Response: select subset.


Instruction: Patients presenting with severesymptomatic iso-lated tricuspid regurgition are commonly associ-ated with what?

Output: ventricle and pulmonary circulation.2. In the evaluation of a patient with valvular heart disease, history and physical examination find-ings should be correlated with the results of noninvasive testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients presenting with severesymptomatic iso-lated tricuspid regurgition are commonly associ-ated with what?. ### Response: ventricle and pulmonary circulation.2. In the evaluation of a patient with valvular heart disease, history and physical examination find-ings should be correlated with the results of noninvasive testing.


Instruction: What is the name of the study that addresses rehabilitation in chronic heart failure?

Output: NICE 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that addresses rehabilitation in chronic heart failure?. ### Response: NICE 2018.


Instruction: What is GRADE?

Output: Quality of the evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is GRADE?. ### Response: Quality of the evidence.


Instruction: The evidence (GRADE) Anticipated absolute effects Risk with centre based exercise training Risk difference with home -based exercise?

Output: bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The evidence (GRADE) Anticipated absolute effects Risk with centre based exercise training Risk difference with home -based exercise?. ### Response: bias.


Instruction: How many studies did MODERATEa due to risk of bias the home?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies did MODERATEa due to risk of bias the home?. ### Response: 2.


Instruction: What was the risk of bias in the home -based exercise training groups?

Output: 0 82 higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk of bias in the home -based exercise training groups?. ### Response: 0 82 higher.


Instruction: Exercise Capacity VO2max 221 (3 studies) 2 to 3 months?

Output: LOWa due to risk of bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Exercise Capacity VO2max 221 (3 studies) 2 to 3 months?. ### Response: LOWa due to risk of bias.


Instruction: What was the mean exercise capacity VO 2max in the centre -based exercise training groups?

Output: 61.73

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean exercise capacity VO 2max in the centre -based exercise training groups?. ### Response: 61.73.


Instruction: What is the risk of bias in the exercise training group?

Output: LOWa

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of bias in the exercise training group?. ### Response: LOWa.


Instruction: How much higher was the VO2max in home exercise training?

Output: 0.09

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much higher was the VO2max in home exercise training?. ### Response: 0.09.


Instruction: How much higher was the exercise capacity – 10 metre walk test (fast) in the intervention group?

Output: 0.9 to 1.1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much higher was the exercise capacity – 10 metre walk test (fast) in the intervention group?. ### Response: 0.9 to 1.1.


Instruction: What was the difference between exercise training groups and intervention groups?

Output: 0 82 higher

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the difference between exercise training groups and intervention groups?. ### Response: 0 82 higher.


Instruction: What was the highe r of the 10 metre walk test in the intervention group?

Output: 1.0

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the highe r of the 10 metre walk test in the intervention group?. ### Response: 1.0.


Instruction: How many studies did the completers complete?

Output: 295

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies did the completers complete?. ### Response: 295.


Instruction: Why was the completion rate VERY LOWa,b due to the risk of bias?

Output: imprecision

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the completion rate VERY LOWa,b due to the risk of bias?. ### Response: imprecision.


Instruction: What is imprecision RR?

Output: 1.19

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is imprecision RR?. ### Response: 1.19.


Instruction: How many more per 1000?

Output: 149

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many more per 1000?. ### Response: 149.


Instruction: What is Adherence to Intervention (Cowie 2012)?

Output: VERY LOW

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Adherence to Intervention (Cowie 2012)?. ### Response: VERY LOW.


Instruction: Why is VERY LOWa,b due to risk of bias, imprecision RR 0.92 (0.62 to 1.36) 800 per 1000 64 fewer per 1000 (from 304 fewer to 288 more) Adherence to intervention (Daskapan 2005)d 29 (1 study) 3 months?

Output: risk of bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is VERY LOWa,b due to risk of bias, imprecision RR 0.92 (0.62 to 1.36) 800 per 1000 64 fewer per 1000 (from 304 fewer to 288 more) Adherence to intervention (Daskapan 2005)d 29 (1 study) 3 months?. ### Response: risk of bias.


Instruction: Why was the study VERY LOWa,b due to risk of bias, imprecision RR 1.19 (0.88 to 1.61) 786 per 1000 149 more per 1000 (from 94 fewer to 479 more) Adherence to intervention (Karapolat 2009)d 74 (1 study)

Output: Exercise Capacity VO2max  221 (3 studies)  2 to 3  months  ⊕⊕⊕⊝  LOWa due to risk of bias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the study VERY LOWa,b due to risk of bias, imprecision RR 1.19 (0.88 to 1.61) 786 per 1000 149 more per 1000 (from 94 fewer to 479 more) Adherence to intervention (Karapolat 2009)d 74 (1 study). ### Response: Exercise Capacity VO2max  221 (3 studies)  2 to 3  months  ⊕⊕⊕⊝  LOWa due to risk of bias.


Instruction: How long did it take to adhere to intervention?

Output: 2 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take to adhere to intervention?. ### Response: 2 months.


Instruction: Why was there a risk of bias?

Output: imprecision

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was there a risk of bias?. ### Response: imprecision.


Instruction: How many fewer studies were there?

Output: 94

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many fewer studies were there?. ### Response: 94.


Instruction: What percentage of hospitals performed/H11350450 procedures?

Output: 1.7%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of hospitals performed/H11350450 procedures?. ### Response: 1.7%.


Instruction: What was the largest OR found for the lowest-volume group?

Output: 1.49

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the largest OR found for the lowest-volume group?. ### Response: 1.49.


Instruction: Desirable processes of care and morbidity rates were not associated with what?

Output: volume

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Desirable processes of care and morbidity rates were not associated with what?. ### Response: volume.


Instruction: What was the averageSTS-CABG composite score for the lowest-volume group significantly lower than?

Output: that of the2 highest-volume groups

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the averageSTS-CABG composite score for the lowest-volume group significantly lower than?. ### Response: that of the2 highest-volume groups.


Instruction: What explained only 1% ofvariation in the composite score?

Output: volume

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What explained only 1% ofvariation in the composite score?. ### Response: volume.


Instruction: The best results are achieved most consistently by high-volume surgeons in what?

Output: high-volume hospitals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The best results are achieved most consistently by high-volume surgeons in what?. ### Response: high-volume hospitals.


Instruction: High-volume surgeons in high-volume hospitals get what?

Output: best results

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: High-volume surgeons in high-volume hospitals get what?. ### Response: best results.


Instruction: Low-volume programs achieve what kind of results?

Output: excellent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Low-volume programs achieve what kind of results?. ### Response: excellent.


Instruction: What is a quality assessment strategy?

Output: participation in a state,regional, or national clinical data registry that providesregular performance feedback reports

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a quality assessment strategy?. ### Response: participation in a state,regional, or national clinical data registry that providesregular performance feedback reports.


Instruction: What are practices derived from larger programs?

Output: best practices

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are practices derived from larger programs?. ### Response: best practices.


Instruction: Participation in a state,regional, or national clinical data registry that provides regular performance feedback reports is highly recommended for all cardiac programs.

Output: quality assessment strategy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Participation in a state,regional, or national clinical data registry that provides regular performance feedback reports is highly recommended for all cardiac programs.. ### Response: quality assessment strategy.


Instruction: Random sampling variation isgreater at what?

Output: low volumes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Random sampling variation isgreater at what?. ### Response: low volumes.


Instruction: What is an example of a statistical methodology that effectively increases the number of endpoints?

Output: hierarchical (random-effects) models

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a statistical methodology that effectively increases the number of endpoints?. ### Response: hierarchical (random-effects) models.


Instruction: What type of measures are used to effectively increase the numbers of endspoints in a program?

Output: composite measures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of measures are used to effectively increase the numbers of endspoints in a program?. ### Response: composite measures.


Instruction: How can small programs benefit from direct supervision by a large tertiary center?

Output: Random sampling variation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can small programs benefit from direct supervision by a large tertiary center?. ### Response: Random sampling variation.


Instruction: What must state ornational regulatory authorities decide?

Output: whether the loweraverage performance of very small programs and the addeddifficulty in accurately measuring their performance areoutweighed by other considerations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must state ornational regulatory authorities decide?. ### Response: whether the loweraverage performance of very small programs and the addeddifficulty in accurately measuring their performance areoutweighed by other considerations.


Instruction: What is an imperfectproxy for direct measurement of outcomes?

Output: Volume

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an imperfectproxy for direct measurement of outcomes?. ### Response: Volume.


Instruction: What is the preferredmethod of assessing CABG quality?

Output: Risk-adjusted outcomes based on clinical data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the preferredmethod of assessing CABG quality?. ### Response: Risk-adjusted outcomes based on clinical data.


Instruction: What makes accurate assessment of performance difficult?

Output: small sample size

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What makes accurate assessment of performance difficult?. ### Response: small sample size.


Instruction: What is the incidence of stroke after CABG?

Output: 1.4% to3.8%,

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the incidence of stroke after CABG?. ### Response: 1.4% to3.8%,.


Instruction: What is one of the risk factors for stroke?

Output: age, history of stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the risk factors for stroke?. ### Response: age, history of stroke.


Instruction: What is another risk factor?

Output: female sex

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another risk factor?. ### Response: female sex.


Instruction: What is the name of the book published by NICE 2018?

Output: Chronic Heart Failure  Methods

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the book published by NICE 2018?. ### Response: Chronic Heart Failure  Methods.


Instruction: What are the names of the books authors?

Output: 978 -1-4731 -3093 -7 58

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the books authors?. ### Response: 978 -1-4731 -3093 -7 58.


Instruction: Where should the practical notes be absorbed?

Output: into the treatment and monitoring recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where should the practical notes be absorbed?. ### Response: into the treatment and monitoring recommendations.


Instruction: What should guideline recommendations be based on?

Output: the expected costs of the different options in relation to their expected health benefits

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should guideline recommendations be based on?. ### Response: the expected costs of the different options in relation to their expected health benefits.


Instruction: What is the committee required to do?

Output: make decisions based on the best available evidence of both clinical effectiveness and cost  effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the committee required to do?. ### Response: make decisions based on the best available evidence of both clinical effectiveness and cost  effectiveness.


Instruction: What is the term for the expected costs of the different options in relation to their expected health benefits?

Output: cost  effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for the expected costs of the different options in relation to their expected health benefits?. ### Response: cost  effectiveness.


Instruction: What does the committee need to be increasingly confident in?

Output: the cost  effectiveness of a recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the committee need to be increasingly confident in?. ### Response: the cost  effectiveness of a recommendation.


Instruction: How can a committee become more confident in the cost effectiveness of a recommendation as the cost of implementation increases?

Output: the committee  may require more robust evidenc e on the effectiveness and cost effectiveness of any recommendations that are expected to have a substantial impact on resources

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can a committee become more confident in the cost effectiveness of a recommendation as the cost of implementation increases?. ### Response: the committee  may require more robust evidenc e on the effectiveness and cost effectiveness of any recommendations that are expected to have a substantial impact on resources.


Instruction: The committee may require more robust evidenc e on the effectiveness and cost effective of recommendations that are expected to have a substantial impact on what?

Output: resources

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committee may require more robust evidenc e on the effectiveness and cost effective of recommendations that are expected to have a substantial impact on what?. ### Response: resources.


Instruction: What must be offset by a compelling argument in favor of the recommendation?

Output: any uncertainties

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must be offset by a compelling argument in favor of the recommendation?. ### Response: any uncertainties.


Instruction: The cost impact or savings potential of a recommendation should not be the sole reason for what?

Output: the committee’ s decision

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The cost impact or savings potential of a recommendation should not be the sole reason for what?. ### Response: the committee’ s decision.


Instruction: What was sought relat ing to the key clinical issues being addressed in the guideline?

Output: Health economic e vidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was sought relat ing to the key clinical issues being addressed in the guideline?. ### Response: Health economic e vidence.


Instruction: What did health economists:  Undertook a systematic review of the published economic literature?

Output: Undertook new cost -effectiveness analysis in priority areas

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did health economists:  Undertook a systematic review of the published economic literature?. ### Response: Undertook new cost -effectiveness analysis in priority areas.


Instruction: Undertood a new cost -effectiveness analysis in priority areas?

Output: Health economist s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Undertood a new cost -effectiveness analysis in priority areas?. ### Response: Health economist s.


Instruction: What criteria were used to identify potentially relevant studies for each review question?

Output: prespecified inclusion and exclusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What criteria were used to identify potentially relevant studies for each review question?. ### Response: prespecified inclusion and exclusion.


Instruction: What were the results of the health economic search?

Output: Identified potentially relevant studies for each review question

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the results of the health economic search?. ### Response: Identified potentially relevant studies for each review question.


Instruction: What criteria were used to identify relevant studies?

Output: inclusion and exclusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What criteria were used to identify relevant studies?. ### Response: inclusion and exclusion.


Instruction: What was used to critically appraise relevant studies using economic evaluation s checklists?

Output: NICE guidelines manual

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was used to critically appraise relevant studies using economic evaluation s checklists?. ### Response: NICE guidelines manual.


Instruction: What is included in appendix G?

Output: health economic evidence tables

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is included in appendix G?. ### Response: health economic evidence tables.


Instruction: Where are summaries of the evidence found?

Output: NICE health economic evidence profile  table s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are summaries of the evidence found?. ### Response: NICE health economic evidence profile  table s.


Instruction: What are included in the relevant chapter for each review question?

Output: Generated summaries of the evidence in NICE health economic evidence profile  table s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are included in the relevant chapter for each review question?. ### Response: Generated summaries of the evidence in NICE health economic evidence profile  table s.


Instruction: 4.4.1.1 Inclusion and exclusion criteria Full economic evaluations (studies compar ing costs and health consequences of alternative courses of action: cost –utility, cost-effectiveness, cost -benefit, and cost-consequence s analyses) and comparative costing studies addressed the review question in the relevant area.

Output: 4.4.1.1  Inclusion and exclusion criteria  Full economic evaluations (studies compar ing costs and health consequences of alternative courses of action: cost –utility, cost -effectiveness, cost –benefit and cost –consequence s analyses) and comparative costing studies that addressed the review question in the relevant population were considered  potentially includable as health economic evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: 4.4.1.1 Inclusion and exclusion criteria Full economic evaluations (studies compar ing costs and health consequences of alternative courses of action: cost –utility, cost-effectiveness, cost -benefit, and cost-consequence s analyses) and comparative costing studies addressed the review question in the relevant area.. ### Response: 4.4.1.1  Inclusion and exclusion criteria  Full economic evaluations (studies compar ing costs and health consequences of alternative courses of action: cost –utility, cost -effectiveness, cost –benefit and cost –consequence s analyses) and comparative costing studies that addressed the review question in the relevant population were considered  potentially includable as health economic evidence.


Instruction: Costing studies that addressed the review question in the relevant population were considered potentially what?

Output: includable as health economic evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Costing studies that addressed the review question in the relevant population were considered potentially what?. ### Response: includable as health economic evidence.


Instruction: Studies that only reported cost per hospital (not per patient) or reported average cost effectiveness without disaggregated costs and effects were excluded from what category?

Output: health economic evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Studies that only reported cost per hospital (not per patient) or reported average cost effectiveness without disaggregated costs and effects were excluded from what category?. ### Response: health economic evidence.


Instruction: What may be used to comple-ment standardized of fice BP readings for the diagnosis andmanagement of high BP in the kidney transplant population?

Output: ABPM or HBPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be used to comple-ment standardized of fice BP readings for the diagnosis andmanagement of high BP in the kidney transplant population?. ### Response: ABPM or HBPM.


Instruction: What is often different from classi ficationusing standardized of fice BP in kidney transplant recipients?

Output: BP statususing out-of-of ﬁce BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is often different from classi ficationusing standardized of fice BP in kidney transplant recipients?. ### Response: BP statususing out-of-of ﬁce BP.


Instruction: What may the complementary use of out-of-fice BP measurements lead to more appropriate therapeutic decisions?

Output: kidney transplant recipients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may the complementary use of out-of-fice BP measurements lead to more appropriate therapeutic decisions?. ### Response: kidney transplant recipients.


Instruction: What is a dihy-dropyridine calcium channel blocker?

Output: CCB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a dihy-dropyridine calcium channel blocker?. ### Response: CCB.


Instruction: What should be used as the first-line antihypertensive agent?

Output: dihy-dropyridine calcium channel blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be used as the first-line antihypertensive agent?. ### Response: dihy-dropyridine calcium channel blocker.


Instruction: What should anARB be used as the first-line antihypertensive agentin adult kidney transplant recipients?

Output: dihy-dropyridine calcium channel blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should anARB be used as the first-line antihypertensive agentin adult kidney transplant recipients?. ### Response: dihy-dropyridine calcium channel blocker.


Instruction: What does the recommendation place a higher value on?

Output: pre-venting kidney allograft loss

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the recommendation place a higher value on?. ### Response: pre-venting kidney allograft loss.