Instruction: Large-scale multicenter observational data will be necessary to achieve adequate statistical power and clarify whether DOACs can be used safely?

Output: patients with congenital heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Large-scale multicenter observational data will be necessary to achieve adequate statistical power and clarify whether DOACs can be used safely?. ### Response: patients with congenital heart disease.


Instruction: What are multicenter registries for?

Output: non-VKA anticoagulants for thromboembolic prevention585a

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are multicenter registries for?. ### Response: non-VKA anticoagulants for thromboembolic prevention585a.


Instruction: What will provide important and needed data on the safety and efficacy of DOACs for thromboembolic prevention in patients with congenital heart disease?

Output: Multicenter registries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will provide important and needed data on the safety and efficacy of DOACs for thromboembolic prevention in patients with congenital heart disease?. ### Response: Multicenter registries.


Instruction: When was this data downloaded from http://ahajournals.org?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this data downloaded from http://ahajournals.org?. ### Response: April 28, 2023.


Instruction: What are writing group members required to recuse themselves from voting on sections to which their specific relationships with industry and other entities may apply?

Output: speci ﬁ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are writing group members required to recuse themselves from voting on sections to which their specific relationships with industry and other entities may apply?. ### Response: speci ﬁ.


Instruction: Dr. Deborah D. Ascheim accepted a position at what company in August 2015?

Output: Capricor Therapeutics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Dr. Deborah D. Ascheim accepted a position at what company in August 2015?. ### Response: Capricor Therapeutics.


Instruction: When was Capricor Therapeutics founded?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Capricor Therapeutics founded?. ### Response: 2015.


Instruction: What is the acronym for the American College of Cardiology?

Output: ACC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the American College of Cardiology?. ### Response: ACC.


Instruction: Where is UCSF located?

Output: University of California San Franci sco

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is UCSF located?. ### Response: University of California San Franci sco.


Instruction: Where is the University of California San Francisco?

Output: UCSF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the University of California San Francisco?. ### Response: UCSF.


Instruction: Where is UT?

Output: University of Texas

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is UT?. ### Response: University of Texas.


Instruction: What is the name of the study that was published in 2015?

Output: Levine et al. J A C CV O L .6 7 ,N O .1 0 ,2 0 1 62015 ACC/AHA/SCAI Focused Update on Primary PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that was published in 2015?. ### Response: Levine et al. J A C CV O L .6 7 ,N O .1 0 ,2 0 1 62015 ACC/AHA/SCAI Focused Update on Primary PCI.


Instruction: How many drinks per day is recommended for people who drink alcohol per day?

Output: ≤2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many drinks per day is recommended for people who drink alcohol per day?. ### Response: ≤2.


Instruction: What is the class of the US Preventive Services Task Force update?

Output: Class I

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the class of the US Preventive Services Task Force update?. ### Response: Class I.


Instruction: How many drinks per day for men might be reason-able?

Output: ≤2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many drinks per day for men might be reason-able?. ### Response: ≤2.


Instruction: What is class IIb; Level of Evidence B?

Output: con-sumption of ≤2 drinks per day for men and ≤1 drink per day for nonpregnant women might be reason-able704,705

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is class IIb; Level of Evidence B?. ### Response: con-sumption of ≤2 drinks per day for men and ≤1 drink per day for nonpregnant women might be reason-able704,705.


Instruction: When was this article downloaded?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this article downloaded?. ### Response: April 28, 2023.


Instruction: Who published the 2017 High Blood Pressure Clinical Practice Guideline e111?

Output: Whelton et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who published the 2017 High Blood Pressure Clinical Practice Guideline e111?. ### Response: Whelton et al.


Instruction: Who is the professor of medicine at ASHYale University School of Medicine?

Output: Aldo J. Peixoto

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the professor of medicine at ASHYale University School of Medicine?. ### Response: Aldo J. Peixoto.


Instruction: What is the title of the Associate Chair for Ambulatory Services Operations and Quality?

Output: Professor of Medicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of the Associate Chair for Ambulatory Services Operations and Quality?. ### Response: Professor of Medicine.


Instruction: Who is the Director of Epidemiology and Prevention at ABCWake Forest University?

Output: Carlos Rodriguez

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Director of Epidemiology and Prevention at ABCWake Forest University?. ### Response: Carlos Rodriguez.


Instruction: What is the title of the Vice-Chair of the Department of Clinical Pharmacy at the Skaggs School of Pharmacy?

Output: izational Reviewer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of the Vice-Chair of the Department of Clinical Pharmacy at the Skaggs School of Pharmacy?. ### Response: izational Reviewer.


Instruction: What is the name of the school of pharmacy in Utah?

Output: University of Utah School of Medicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the school of pharmacy in Utah?. ### Response: University of Utah School of Medicine.


Instruction: Who is the Chief of the Division of Geriatrics?

Output: McGraw-Hill Medical

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Chief of the Division of Geriatrics?. ### Response: McGraw-Hill Medical.


Instruction: Who is the Chief, Division of Geriatrics?

Output: McGraw-Hill Medical

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Chief, Division of Geriatrics?. ### Response: McGraw-Hill Medical.


Instruction: What is the name of the University of Utah Center on Aging Executive?

Output: —Director

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the University of Utah Center on Aging Executive?. ### Response: —Director.


Instruction: Who is a Content Reviewer?

Output: Sana M. Al-Khatib

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a Content Reviewer?. ### Response: Sana M. Al-Khatib.


Instruction: Who is Professor of Medicine at the University of Chicago?

Output: George Bakris

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Professor of Medicine at the University of Chicago?. ### Response: George Bakris.


Instruction: Who is Director of Hypertensive Diseases Unit?

Output: George Bakris

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Director of Hypertensive Diseases Unit?. ### Response: George Bakris.


Instruction: Who is Professor of Medicine?

Output: Seinsheimer Cardiovascular Health Program

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Professor of Medicine?. ### Response: Seinsheimer Cardiovascular Health Program.


Instruction: AbbVie, Inc., Janssen, Bayer, Relypsa, None None

Output: pertensive Diseases Unit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: AbbVie, Inc., Janssen, Bayer, Relypsa, None None. ### Response: pertensive Diseases Unit.


Instruction: Who is the Director of Cardiovascular Fellowship Program at Vanderbilt University Medical Center?

Output: Joshua A. Beckman

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Director of Cardiovascular Fellowship Program at Vanderbilt University Medical Center?. ### Response: Joshua A. Beckman.


Instruction: Who was the 2015 Defendant?

Output: Venous thromboembolism*John Bisognano

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the 2015 Defendant?. ### Response: Venous thromboembolism*John Bisognano.


Instruction: What was the name of the ACC/AHA Task Force on Clinical Practice Guidelines?

Output: Biykem BozkurtContent Reviewer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the ACC/AHA Task Force on Clinical Practice Guidelines?. ### Response: Biykem BozkurtContent Reviewer.


Instruction: Which college of medicine was the Medical Care Line Executive?

Output: Baylor College of Medicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which college of medicine was the Medical Care Line Executive?. ### Response: Baylor College of Medicine.


Instruction: What is the name of the professor of medicine at Baylor College of Medicine?

Output: Debakey

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor of medicine at Baylor College of Medicine?. ### Response: Debakey.


Instruction: What company is listed in Appendix 2?

Output: Novartis Corporation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What company is listed in Appendix 2?. ### Response: Novartis Corporation.


Instruction: Who is listed as an Employment Consultant Speakers Bureau?

Output: Ownership/Partnership/

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is listed as an Employment Consultant Speakers Bureau?. ### Response: Ownership/Partnership/.


Instruction: What is the AHA's science advisory on resistance exercise in individuals with and without cardiovascular disease?

Output: Life’s Simple 7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the AHA's science advisory on resistance exercise in individuals with and without cardiovascular disease?. ### Response: Life’s Simple 7.


Instruction: What are the benefits, rationale, safety, and prescription?

Output: resistance exercise in individuals with and without cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the benefits, rationale, safety, and prescription?. ### Response: resistance exercise in individuals with and without cardiovascular disease.


Instruction: What is the name of the group that advised the American Heart Association on exercise, rehabilitation, and prevention?

Output: the Committee on Exercise, Rehabilitation, and Prevention, Council on Clinical Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the group that advised the American Heart Association on exercise, rehabilitation, and prevention?. ### Response: the Committee on Exercise, Rehabilitation, and Prevention, Council on Clinical Cardiology.


Instruction: What is a pilot test of an integrated self-care intervention for persons with heart failure and diabetes?

Output: Dunbar SB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a pilot test of an integrated self-care intervention for persons with heart failure and diabetes?. ### Response: Dunbar SB.


Instruction: What is an integrated self-care intervention for persons with heart failure and concomitant diabetes?

Output: A pilot test

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an integrated self-care intervention for persons with heart failure and concomitant diabetes?. ### Response: A pilot test.


Instruction: What is the doi: 10.1016/j.outlook.2013.09.003?

Output: Nurs Outlook. 2014;62:97–111

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the doi: 10.1016/j.outlook.2013.09.003?. ### Response: Nurs Outlook. 2014;62:97–111.


Instruction: Wald NJ, Law MR. A strategy to reduce cardiovascular dis-ease by more than what percentage?

Output: 80%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Wald NJ, Law MR. A strategy to reduce cardiovascular dis-ease by more than what percentage?. ### Response: 80%.


Instruction: What is the age-specific relevance of usual blood pressure to vascular mortality?

Output: a meta-analysis of individual data for one million adults in 61 prospective studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the age-specific relevance of usual blood pressure to vascular mortality?. ### Response: a meta-analysis of individual data for one million adults in 61 prospective studies.


Instruction: How many prospective studies did a meta-analysis of individual data for one million adults in?

Output: 61

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many prospective studies did a meta-analysis of individual data for one million adults in?. ### Response: 61.


Instruction: What is the name of the American Heart Association's Life's Simple 7 Tool Kit?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the American Heart Association's Life's Simple 7 Tool Kit?. ### Response: American Heart Association.


Instruction: When was the life's simple 7 tool kit first published?

Output: April 17, 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the life's simple 7 tool kit first published?. ### Response: April 17, 2013.


Instruction: On behalf of the American Heart Association Strategic Planning Task Force and Statistics Committee, what group did Horn L, Greenlund K, Daniels S, Nichol G, Tomaselli GF, Fonarow GC, Ho PM, Lauer MS, Masoudi FA, Robertson RM, Roger V, Schwamm LH, Sorlie P, and Rosamond WD represent?

Output: Lloyd-Jones DM, Hong Y, Labarthe D, Mozaffarian D, Appel LJ, Van Horn L, Greenlund K, Daniels S, Nichol G, Tomaselli GF, Arnett DK, Fonarow GC, Ho PM, Lauer MS, Masoudi FA, Robertson RM, Roger V, Schwamm LH, Sorlie P, Yancy CW, Rosamond WD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On behalf of the American Heart Association Strategic Planning Task Force and Statistics Committee, what group did Horn L, Greenlund K, Daniels S, Nichol G, Tomaselli GF, Fonarow GC, Ho PM, Lauer MS, Masoudi FA, Robertson RM, Roger V, Schwamm LH, Sorlie P, and Rosamond WD represent?. ### Response: Lloyd-Jones DM, Hong Y, Labarthe D, Mozaffarian D, Appel LJ, Van Horn L, Greenlund K, Daniels S, Nichol G, Tomaselli GF, Arnett DK, Fonarow GC, Ho PM, Lauer MS, Masoudi FA, Robertson RM, Roger V, Schwamm LH, Sorlie P, Yancy CW, Rosamond WD.


Instruction: What is the acronym for the American Heart Association's strategic impact goal through 2020?

Output: CIRCULATIONAHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the American Heart Association's strategic impact goal through 2020?. ### Response: CIRCULATIONAHA.


Instruction: What are the names of the two committees that are responsible for defining and setting national goals for cardiovascular health promotion and disease reduc-tion?

Output: Strategic Planning Task Force and Statistics Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the two committees that are responsible for defining and setting national goals for cardiovascular health promotion and disease reduc-tion?. ### Response: Strategic Planning Task Force and Statistics Committee.


Instruction: When was the Strategic Impact Goal released?

Output: May 3, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Strategic Impact Goal released?. ### Response: May 3, 2023.


Instruction: What are patients who have received protamine sulfate-containing insulin at increased risk of having?

Output: preformed antibodies against protamine sulfate and to suffer from allergic reactions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients who have received protamine sulfate-containing insulin at increased risk of having?. ### Response: preformed antibodies against protamine sulfate and to suffer from allergic reactions.


Instruction: What type of reaction does anaphylaxis include?

Output: allergic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of reaction does anaphylaxis include?. ### Response: allergic.


Instruction: What is a common allergic reaction to protamine sulfate?

Output: anaphylaxis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a common allergic reaction to protamine sulfate?. ### Response: anaphylaxis.


Instruction: What can patients be pretreated with if they have concerns about a potential allergy?

Output: corticoste-roids and antihistamines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can patients be pretreated with if they have concerns about a potential allergy?. ### Response: corticoste-roids and antihistamines.


Instruction: Corticosteroids and antihistamines can be used to treat what?

Output: protamine sulfate allergy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Corticosteroids and antihistamines can be used to treat what?. ### Response: protamine sulfate allergy.


Instruction: What other substance has been shown to neutralize the anticoagulant effects of UFH?

Output: hexadimethrine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What other substance has been shown to neutralize the anticoagulant effects of UFH?. ### Response: hexadimethrine.


Instruction: What is hexadimethrine?

Output: Polybrene

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hexadimethrine?. ### Response: Polybrene.


Instruction: What are 107 and synthetic protamine variants?

Output: extracorporeal heparin removal devices

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are 107 and synthetic protamine variants?. ### Response: extracorporeal heparin removal devices.


Instruction: None of these are approved for what?

Output: clinical use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: None of these are approved for what?. ### Response: clinical use.


Instruction: What are Low-Molecular-Weight Heparins derived from?

Output: UFH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are Low-Molecular-Weight Heparins derived from?. ### Response: UFH.


Instruction: What has a more favorable benefi t-to-risk ratio than heparin in animal models 112,113?

Output: 9,10,109-111

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has a more favorable benefi t-to-risk ratio than heparin in animal models 112,113?. ### Response: 9,10,109-111.


Instruction: When used to treat VTE, what has superior pharmacokinetic properties?

Output: LMWHs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When used to treat VTE, what has superior pharmacokinetic properties?. ### Response: LMWHs.


Instruction: What are LMWHs about one-third the molecular weight of?

Output: UFH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are LMWHs about one-third the molecular weight of?. ### Response: UFH.


Instruction: How many saccharide units does a LMW have?

Output: 15

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many saccharide units does a LMW have?. ### Response: 15.


Instruction: What is a range of 2,000 to 9,000?

Output: LMWHs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a range of 2,000 to 9,000?. ### Response: LMWHs.


Instruction: How many saccharide units are in the range of 2,000 to 9,000?

Output: 15

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many saccharide units are in the range of 2,000 to 9,000?. ### Response: 15.


Instruction: Where are the various LMWHs approved for use?

Output: Europe, Canada, and the United States

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are the various LMWHs approved for use?. ### Response: Europe, Canada, and the United States.


Instruction: What are the different methods of depolymerization used for?

Output: pre-pared

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the different methods of depolymerization used for?. ### Response: pre-pared.


Instruction: What are LMWHs not interchangeable on a unit-for-unit basis?

Output: these drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are LMWHs not interchangeable on a unit-for-unit basis?. ### Response: these drugs.


Instruction: What induces hypotension by promoting the activation of factor XII and the sub-sequent generation of bradykinin?

Output: oversulfated chondroitin sulfate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What induces hypotension by promoting the activation of factor XII and the sub-sequent generation of bradykinin?. ### Response: oversulfated chondroitin sulfate.


Instruction: What type of therapy can cause elevations of serum transaminases?

Output: Heparin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy can cause elevations of serum transaminases?. ### Response: Heparin therapy.


Instruction: What is usually transient and is not associated with an increase in bilirubin?

Output: The increase in transaminases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is usually transient and is not associated with an increase in bilirubin?. ### Response: The increase in transaminases.


Instruction: What are the main nonhemorrhagic side effects of heparin?

Output: HIT and osteoporosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the main nonhemorrhagic side effects of heparin?. ### Response: HIT and osteoporosis.


Instruction: What is caused by IgG subclass?

Output: HIT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is caused by IgG subclass?. ### Response: HIT.


Instruction: What are IgG subclass, heparin-dependent antibodies?

Output: anti-bodies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are IgG subclass, heparin-dependent antibodies?. ### Response: anti-bodies.


Instruction: What do these anti-bodies bind to?

Output: a conformationally modiﬁ  ed epitope

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do these anti-bodies bind to?. ### Response: a conformationally modiﬁ  ed epitope.


Instruction: What is ICD deactivation equivalent to?

Output: suicide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ICD deactivation equivalent to?. ### Response: suicide.


Instruction: What is another term for advanced heart failure?

Output: Chronic Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for advanced heart failure?. ### Response: Chronic Heart Failure.


Instruction: What did some people believe to be equivalent to euthanasia or assisted suicide?

Output: ICD deactivation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did some people believe to be equivalent to euthanasia or assisted suicide?. ### Response: ICD deactivation.


Instruction: When did they want to consider deactivation?

Output: when they were ‘brain dead

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did they want to consider deactivation?. ### Response: when they were ‘brain dead.


Instruction: Did they feel a cardiac arrest was a threat to their lives?

Output: They felt that a cardiac arrest was a threat to their lives

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Did they feel a cardiac arrest was a threat to their lives?. ### Response: They felt that a cardiac arrest was a threat to their lives.


Instruction: What were healthcare professionals obligated to treat?

Output: cardiac arrest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were healthcare professionals obligated to treat?. ### Response: cardiac arrest.


Instruction: Why did some patients say they would never want their ICD to be deactivated?

Output: this was the equ ivalent to suicide and therefore against their faith

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why did some patients say they would never want their ICD to be deactivated?. ### Response: this was the equ ivalent to suicide and therefore against their faith.


Instruction: What was the equ ivalent to suicide and therefore against their faith?

Output: ICD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the equ ivalent to suicide and therefore against their faith?. ### Response: ICD.


Instruction: What type of limitations are there in the studies contributing to this sub-finding?

Output: moderate  methodological

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of limitations are there in the studies contributing to this sub-finding?. ### Response: moderate  methodological.


Instruction: What are some concerns about the coherence of the finding?

Output: conflicting reports regarding patients and family members wanting to deactivate their device

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some concerns about the coherence of the finding?. ### Response: conflicting reports regarding patients and family members wanting to deactivate their device.


Instruction: What country had moderate concerns about inadequacy?

Output: UK

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What country had moderate concerns about inadequacy?. ### Response: UK.


Instruction: What was the overall judgement of low confidence in this sub-finding?

Output: very low confidence in this sub-finding  due to the concerns regarding the methodological limitations, relevance and adequacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the overall judgement of low confidence in this sub-finding?. ### Response: very low confidence in this sub-finding  due to the concerns regarding the methodological limitations, relevance and adequacy.


Instruction: What are concerns regarding the methodological limitations, relevance and adequacy of the study?

Output: very low confidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are concerns regarding the methodological limitations, relevance and adequacy of the study?. ### Response: very low confidence.


Instruction: What would some people not consider living without their ICD because they believed it was keeping them alive?

Output: suicide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would some people not consider living without their ICD because they believed it was keeping them alive?. ### Response: suicide.


Instruction: What should always be replaced when the batteries ran out?

Output: the ICD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should always be replaced when the batteries ran out?. ### Response: the ICD.


Instruction: What would the y choose at all costs and would not want to deactivate their ICD when it could extend life?

Output: life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would the y choose at all costs and would not want to deactivate their ICD when it could extend life?. ### Response: life.


Instruction: What did some ICD recipients call the situation in which they would choose to deactivate their device?

Output: when their quality of life was so low that they were bedridden or unable to engage in dai ly activities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did some ICD recipients call the situation in which they would choose to deactivate their device?. ### Response: when their quality of life was so low that they were bedridden or unable to engage in dai ly activities.


Instruction: What was a moderate methodological limitation in the studies contributing to quality assessment?

Output: minor concerns about the coherence of the finding ; partial relevance due to the contributing studies being conducted outside of the UK ; moderate  concerns about inadequacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a moderate methodological limitation in the studies contributing to quality assessment?. ### Response: minor concerns about the coherence of the finding ; partial relevance due to the contributing studies being conducted outside of the UK ; moderate  concerns about inadequacy.


Instruction: What type of limitations were there in the studies contributing to this sub -finding?

Output: moderate  methodological

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of limitations were there in the studies contributing to this sub -finding?. ### Response: moderate  methodological.


Instruction: What were concerns about the coherence of the findings due to?

Output: conflicting reports regarding patients and family members wanting to deactivate their device

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were concerns about the coherence of the findings due to?. ### Response: conflicting reports regarding patients and family members wanting to deactivate their device.


Instruction: There were moderate concerns about inadequacy as there was a relatively small amount of what?

Output: evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There were moderate concerns about inadequacy as there was a relatively small amount of what?. ### Response: evidence.


Instruction: What was the overall judgement of low confidence in?

Output: sub-finding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the overall judgement of low confidence in?. ### Response: sub-finding.


Instruction: What was the judgement of low confidence in this sub-finding?

Output: very low confidence in this sub-finding  due to the concerns regarding the methodological limitations, relevance and adequacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the judgement of low confidence in this sub-finding?. ### Response: very low confidence in this sub-finding  due to the concerns regarding the methodological limitations, relevance and adequacy.


Instruction: What were concerns regarding the methodological limitations, relevance, and adequacy of the study?

Output: very low confidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were concerns regarding the methodological limitations, relevance, and adequacy of the study?. ### Response: very low confidence.


Instruction: Review sub - finding 4 : Wanting to deactivate Some ICD recipients felt that they would only do what?

Output: deactivate their device

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Review sub - finding 4 : Wanting to deactivate Some ICD recipients felt that they would only do what?. ### Response: deactivate their device.


Instruction: What did they do when their quality of life was so low that they were bedridden or unable to engage in dai ly activities?

Output: deactivate their device

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did they do when their quality of life was so low that they were bedridden or unable to engage in dai ly activities?. ### Response: deactivate their device.


Instruction: What would they want to do if they had no hope of a meaningful recovery?

Output: deactivate their ICD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would they want to do if they had no hope of a meaningful recovery?. ### Response: deactivate their ICD.


Instruction: What year is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction?

Output: 2020

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction?. ### Response: 2020.


Instruction: How old is the P age 111 of 127 Question Set # Concept Strategy Question 5 – Pharmacologic treatment to reach specific LDL -C or non-HDL-C goals #1

Output: 2020

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old is the P age 111 of 127 Question Set # Concept Strategy Question 5 – Pharmacologic treatment to reach specific LDL -C or non-HDL-C goals #1. ### Response: 2020.


Instruction: What type of goals do you need to reach to reach specific LDL -C or non -HDL-C goals?

Output: exp Cholesterol, HDL/bl OR exp Cholesterol, LDL/bl OR exp lipids

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of goals do you need to reach to reach specific LDL -C or non -HDL-C goals?. ### Response: exp Cholesterol, HDL/bl OR exp Cholesterol, LDL/bl OR exp lipids.


Instruction: Dyslipidemia exp dyslipidemias/ OR exp cholesterol/ OR what else?

Output: lipids

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Dyslipidemia exp dyslipidemias/ OR exp cholesterol/ OR what else?. ### Response: lipids.


Instruction: Hyperlipemia OR hyperlipaemia OR (high OR elevated OR low) ADJ5 (cholesteryl* OR cholesterol* OR lipid* OR lipoprotein* OR tryglycer* OR triaclyglycer* OR "HDL -C" OR "LDL C"))?

Output: hyperlipemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hyperlipemia OR hyperlipaemia OR (high OR elevated OR low) ADJ5 (cholesteryl* OR cholesterol* OR lipid* OR lipoprotein* OR tryglycer* OR triaclyglycer* OR "HDL -C" OR "LDL C"))?. ### Response: hyperlipemia.


Instruction: ti,ab. #2 CVD exp *Cardiovascular Diseases/pc OR what?

Output: cardiovascular diseases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ti,ab. #2 CVD exp *Cardiovascular Diseases/pc OR what?. ### Response: cardiovascular diseases.


Instruction: What type of diseases are exp *Cardiovascular Diseases/pc OR heart diseases/ or vascular diseases/or cerebrovascular disorders/or brain ischemia/or stroke/or myocardial infarction/or exp heart arrest/OR exp hypertension/OR ((heart*))) exp peripheral vascular disease/ OR exp cerebral occlusive diseases/ OR what type of disease is exp stroke?

Output: cardiovascular

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diseases are exp *Cardiovascular Diseases/pc OR heart diseases/ or vascular diseases/or cerebrovascular disorders/or brain ischemia/or stroke/or myocardial infarction/or exp heart arrest/OR exp hypertension/OR ((heart*))) exp peripheral vascular disease/ OR exp cerebral occlusive diseases/ OR what type of disease is exp stroke?. ### Response: cardiovascular.


Instruction: What type of disease is exp hypertension?

Output: peripheral vascular diseases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of disease is exp hypertension?. ### Response: peripheral vascular diseases.


Instruction: What is exp peripheral vascular diseases?

Output: OR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is exp peripheral vascular diseases?. ### Response: OR.


Instruction: What is an example of a heart ADJ attack?

Output: hyperten* OR atherosclero* OR arteriosclero* OR angina

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a heart ADJ attack?. ### Response: hyperten* OR atherosclero* OR arteriosclero* OR angina.


Instruction: What is a possible cause of an ischebrovascular ADJ accident?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a possible cause of an ischebrovascular ADJ accident?. ### Response: stroke.


Instruction: What is another word for goal OR goals OR target* OR level OR levels?

Output: ADJ5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another word for goal OR goals OR target* OR level OR levels?. ### Response: ADJ5.


Instruction: What is the other word for "exp Cholesterol, HDL, LDL, or exp lipids/ OR exp cholesterol/) AND exp goals?

Output: dyslipidemias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the other word for "exp Cholesterol, HDL, LDL, or exp lipids/ OR exp cholesterol/) AND exp goals?. ### Response: dyslipidemias.


Instruction: What does ADJ5 stand for?

Output: reductase ADJ inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ADJ5 stand for?. ### Response: reductase ADJ inhibitor.


Instruction: What is another word for "goal OR goals OR target* OR level OR levels?"

Output: ADJ5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another word for "goal OR goals OR target* OR level OR levels?". ### Response: ADJ5.


Instruction: What drug combination does Ezetimibe, Simvastatin, or exp Anticholesteremic Agents/ or exp Hydroxymethylglutaryl -CoA Reductase Inhibitors?

Output: ipidemic Agents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug combination does Ezetimibe, Simvastatin, or exp Anticholesteremic Agents/ or exp Hydroxymethylglutaryl -CoA Reductase Inhibitors?. ### Response: ipidemic Agents.


Instruction: What is the name of the non-statin drug combination?

Output: Simvastatin Drug Combination

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the non-statin drug combination?. ### Response: Simvastatin Drug Combination.


Instruction: Non-statins Gemfibrozil or fenofibrate or niacin or exp Fatty Acids, Omega -3/ or exp Ezetimibe/ or exp Proprotein Convertase 9/tu or exp "Bile Acids and Salts" or tu OR (fibre* or gemfibrozil or bezafibric acid or (nicotinic ADJ acid* or (bile AdJ acid ADJ sequestrant*) or

Output: ipidemic Agents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Non-statins Gemfibrozil or fenofibrate or niacin or exp Fatty Acids, Omega -3/ or exp Ezetimibe/ or exp Proprotein Convertase 9/tu or exp "Bile Acids and Salts" or tu OR (fibre* or gemfibrozil or bezafibric acid or (nicotinic ADJ acid* or (bile AdJ acid ADJ sequestrant*) or. ### Response: ipidemic Agents.


Instruction: What is another name for niacin?

Output: fenofibrate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for niacin?. ### Response: fenofibrate.


Instruction: What does ezetimibe stand for?

Output: ipidemic Agents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ezetimibe stand for?. ### Response: ipidemic Agents.


Instruction: What did Secondary Mitral Regurgitation (SMR) enroll patients with greater degrees of?

Output: reduction in MR sever -ity with TEER is associated with greater  LV and LA reverse remodeling

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Secondary Mitral Regurgitation (SMR) enroll patients with greater degrees of?. ### Response: reduction in MR sever -ity with TEER is associated with greater  LV and LA reverse remodeling.


Instruction: What was the mean ERO area of patients with LV enlargement?

Output: 0.31 cm2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean ERO area of patients with LV enlargement?. ### Response: 0.31 cm2.


Instruction: How many patients reported no benefit of TEER in reducing the composite endpoint of death or hospitalization as compared with medical therapy?

Output: patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients reported no benefit of TEER in reducing the composite endpoint of death or hospitalization as compared with medical therapy?. ### Response: patients.


Instruction: What is the inclusion criterion in MITRA-FR?

Output: extreme dilation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the inclusion criterion in MITRA-FR?. ### Response: extreme dilation.


Instruction: What was the mean LVESD in the COAPT trial?

Output: ≤70 mm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean LVESD in the COAPT trial?. ### Response: ≤70 mm.


Instruction: What is the mean mm in mm?

Output: 62±7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the mean mm in mm?. ### Response: 62±7.


Instruction: What are the current standard selection criteria for TEER for secondary MR?

Output: enrollment criteria in COAPT trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the current standard selection criteria for TEER for secondary MR?. ### Response: enrollment criteria in COAPT trial.


Instruction: What is the current standard selection criteria for TEER for secondary MR?

Output: enrollment criteria in COAPT trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the current standard selection criteria for TEER for secondary MR?. ### Response: enrollment criteria in COAPT trial.


Instruction: What is associated with a greater reduction in MR sever -ity with TIER?

Output: LV and LA reverse remodeling

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with a greater reduction in MR sever -ity with TIER?. ### Response: LV and LA reverse remodeling.


Instruction: The exact anatomy and mechanism of MR also needs to be taken into consideration when determining what?

Output: candidacy for transcatheter repair

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The exact anatomy and mechanism of MR also needs to be taken into consideration when determining what?. ### Response: candidacy for transcatheter repair.


Instruction: What should be taken into consideration when determining candidacy for transcatheter repair?

Output: The exact anatomy and mechanism of MR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be taken into consideration when determining candidacy for transcatheter repair?. ### Response: The exact anatomy and mechanism of MR.


Instruction: There is no proof that surgical correction of chronic secondary MR is effective in prolonging what?

Output: life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is no proof that surgical correction of chronic secondary MR is effective in prolonging what?. ### Response: life.


Instruction: What valve should be addressed during CABG for severe CAD when secondary MR is severe?

Output: mitral valve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What valve should be addressed during CABG for severe CAD when secondary MR is severe?. ### Response: mitral valve.


Instruction: What may be hoped that the revascularization will recruit hibernating myocardium and reduce?

Output: chronic secondary MR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be hoped that the revascularization will recruit hibernating myocardium and reduce?. ### Response: chronic secondary MR.


Instruction: What may leave a patient with severe residual MR?

Output: failing to correct chronic severe secondary MR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may leave a patient with severe residual MR?. ### Response: failing to correct chronic severe secondary MR.


Instruction: What should be weighed in patients with LV systolic dysfunc-tion?

Output: The risks and benefits of additional surgical interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be weighed in patients with LV systolic dysfunc-tion?. ### Response: The risks and benefits of additional surgical interventions.


Instruction: What may develop in patients with preserved LV systolic function who have progressive LA dila-tion?

Output: MR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may develop in patients with preserved LV systolic function who have progressive LA dila-tion?. ### Response: MR.


Instruction: What can lead to enlargement of the mitral annu-lus and malcoaptation of the leaflets?

Output: progressive LA dila-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can lead to enlargement of the mitral annu-lus and malcoaptation of the leaflets?. ### Response: progressive LA dila-tion.


Instruction: What may occur in conditions such as HF with preserved LVEF and restrictive cardiomyopathy?

Output: MR may develop in patients with preserved LV systolic function who have progressive LA dila-tion, leading to enlargement of the mitral annu-lus and malcoaptation of the leaflets

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may occur in conditions such as HF with preserved LVEF and restrictive cardiomyopathy?. ### Response: MR may develop in patients with preserved LV systolic function who have progressive LA dila-tion, leading to enlargement of the mitral annu-lus and malcoaptation of the leaflets.


Instruction: What may contribute to the progression of LA and annular dilation?

Output: AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may contribute to the progression of LA and annular dilation?. ### Response: AF.


Instruction: What may reduce or eliminate MR?

Output: suc-cessful ablation of AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may reduce or eliminate MR?. ### Response: suc-cessful ablation of AF.


Instruction: What accounts for 20% of patients referred for surgery of severe MR in the STS database?

Output: LVEF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What accounts for 20% of patients referred for surgery of severe MR in the STS database?. ### Response: LVEF.


Instruction: What is a systematic review and meta-analysis of mechanical heart valves?

Output: Anticoagulation for pregnant women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a systematic review and meta-analysis of mechanical heart valves?. ### Response: Anticoagulation for pregnant women.


Instruction: What is Steinberg ZL, Dominguez-Islas CP, Otto CM, et al. Maternal and fetal outcomes of anticoagulation in pregnant women?

Output: mechanical heart valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Steinberg ZL, Dominguez-Islas CP, Otto CM, et al. Maternal and fetal outcomes of anticoagulation in pregnant women?. ### Response: mechanical heart valves.


Instruction: What improves risk assessment of prosthetic heart valves?

Output: Transesophageal echocardiogra-phy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What improves risk assessment of prosthetic heart valves?. ### Response: Transesophageal echocardiogra-phy.


Instruction: What is a report from the European Association of Cardiovascular Imaging?

Output: Recommendations for the im-aging assessment of prosthetic heart valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a report from the European Association of Cardiovascular Imaging?. ### Response: Recommendations for the im-aging assessment of prosthetic heart valves.


Instruction: When was the Eur Heart J Cardiovasc Imaging published?

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Eur Heart J Cardiovasc Imaging published?. ### Response: 2016.


Instruction: What improves risk assessment of thrombolysis of prosthetic valve throm-bosis?

Output: Transesophageal echocardiogra-phy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What improves risk assessment of thrombolysis of prosthetic valve throm-bosis?. ### Response: Transesophageal echocardiogra-phy.


Instruction: What does transesophageal echocardiogra-phy improve?

Output: risk assessment of thrombolysis of prosthetic valve throm-bosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does transesophageal echocardiogra-phy improve?. ### Response: risk assessment of thrombolysis of prosthetic valve throm-bosis.


Instruction: When did J Am Coll Cardiol 200443:77–84?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J Am Coll Cardiol 200443:77–84?. ### Response: 2004.


Instruction: What is used to treat prosthetic heart valve thrombosis in pregnancy?

Output: Thrombolytic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used to treat prosthetic heart valve thrombosis in pregnancy?. ### Response: Thrombolytic therapy.


Instruction: What is the name of the tissue-type plasminogen activator that is used in the treatment of prosthetic hearts?

Output: low-dose, slow infusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the tissue-type plasminogen activator that is used in the treatment of prosthetic hearts?. ### Response: low-dose, slow infusion.


Instruction: When did Circulation. 2013 issue 128:532–40?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circulation. 2013 issue 128:532–40?. ### Response: 2013.


Instruction: In what year did the J Am Coll Cardiol issue 68:1804–13?

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did the J Am Coll Cardiol issue 68:1804–13?. ### Response: 2016.


Instruction: When did J Am Coll Cardiol. 2004;43:77–84?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did J Am Coll Cardiol. 2004;43:77–84?. ### Response: 2004.


Instruction: What is thrombolytic therapy used for?

Output: the treatment of prosthetic heart valve thrombosis in pregnancy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is thrombolytic therapy used for?. ### Response: the treatment of prosthetic heart valve thrombosis in pregnancy.


Instruction: What is low-dose, slow-infusion of tissue-type plasminogen activator?

Output: Thrombolytic therapy for the treatment of prosthetic heart valve thrombosis in pregnancy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is low-dose, slow-infusion of tissue-type plasminogen activator?. ### Response: Thrombolytic therapy for the treatment of prosthetic heart valve thrombosis in pregnancy.


Instruction: How is anticoagulation for pregnant women with mechanical heart valves?

Output: Maternal and fetal outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is anticoagulation for pregnant women with mechanical heart valves?. ### Response: Maternal and fetal outcomes.


Instruction: What is a focus of this study?

Output: mechanical valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a focus of this study?. ### Response: mechanical valves.


Instruction: What is the name of the study that focuses on mechanical valves during pregnancy?

Output: Anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that focuses on mechanical valves during pregnancy?. ### Response: Anticoagulation.


Instruction: When was this study published?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this study published?. ### Response: 2013.


Instruction: Where did this study focus on?

Output: mechanical valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where did this study focus on?. ### Response: mechanical valves.


Instruction: What is the name of the systematic review and meta-analysis of anticoagulation for pregnant women with mechanical heart valves?

Output: meta-anal-ysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta-analysis of anticoagulation for pregnant women with mechanical heart valves?. ### Response: meta-anal-ysis.


Instruction: What is Chan WS, Anand S, Ginsberg JS?

Output: Anticoagulation of pregnant women with mechanical heart valves: a systematic review of the literature

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Chan WS, Anand S, Ginsberg JS?. ### Response: Anticoagulation of pregnant women with mechanical heart valves: a systematic review of the literature.


Instruction: What is the name of the systematic review of the literature on women with mechanical heart valves?

Output: Anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review of the literature on women with mechanical heart valves?. ### Response: Anticoagulation.


Instruction: What are the outcomes for women and their babies?

Output: Maternal and fetal outcomes of anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the outcomes for women and their babies?. ### Response: Maternal and fetal outcomes of anticoagulation.


Instruction: Who is the author of a systematic review and meta-analysis?

Output: D’Souza R, Ostro J, Shah PS, et al. Anticoagulation for pregnant women with mechanical heart valves: a systematic review and meta-analysis. Eur Heart J. 2017;38:1509–16. 4. Chan WS, Anand S, Ginsberg JS. Anticoagulation of pregnant women with mechanical heart valves: a systematic review of the literature. Arch Intern Med. 2000;160:191–6. 5. Lawley CM, Lain SJ, Algert CS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of a systematic review and meta-analysis?. ### Response: D’Souza R, Ostro J, Shah PS, et al. Anticoagulation for pregnant women with mechanical heart valves: a systematic review and meta-analysis. Eur Heart J. 2017;38:1509–16. 4. Chan WS, Anand S, Ginsberg JS. Anticoagulation of pregnant women with mechanical heart valves: a systematic review of the literature. Arch Intern Med. 2000;160:191–6. 5. Lawley CM, Lain SJ, Algert CS.


Instruction: What is the name of the systematic review of anticoagulation regimens during pregnancy in patients with mechanical heart valves?

Output: meta-anal-ysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review of anticoagulation regimens during pregnancy in patients with mechanical heart valves?. ### Response: meta-anal-ysis.


Instruction: What are the results and long-term effects of pregnancy in women with biologic and non-biologic heart valve patients?

Output: Maternal and fetal outcomes of anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results and long-term effects of pregnancy in women with biologic and non-biologic heart valve patients?. ### Response: Maternal and fetal outcomes of anticoagulation.


Instruction: What type of valve prostheses do women with biologic and mechanical valve prosthesis have?

Output: Prosthetic heart valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of valve prostheses do women with biologic and mechanical valve prosthesis have?. ### Response: Prosthetic heart valves.


Instruction: What is the name of the journal that studies the long-term effects of pregnancy?

Output: iovasc Imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies the long-term effects of pregnancy?. ### Response: iovasc Imaging.


Instruction: What is the risk of atherothrombosis?

Output: Meta-analysis of randomised trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of atherothrombosis?. ### Response: Meta-analysis of randomised trials.


Instruction: When did BMJ publish a meta-analysis of randomised trials?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did BMJ publish a meta-analysis of randomised trials?. ### Response: 2006.


Instruction: What did Peacock WF, Hollander JE, Diercks DB, et al. say about Morphine and outcomes in acute decompensated heart failure?

Output: an ADHERE analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Peacock WF, Hollander JE, Diercks DB, et al. say about Morphine and outcomes in acute decompensated heart failure?. ### Response: an ADHERE analysis.


Instruction: What is an update for clinicians?

Output: Use of nonsteroidal antiin-flammatory drugs: an update for clinicians: a scientific statement from the American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an update for clinicians?. ### Response: Use of nonsteroidal antiin-flammatory drugs: an update for clinicians: a scientific statement from the American Heart Association.


Instruction: What is a scientific statement from the American Heart Association?

Output: Use of nonsteroidal antiin-flammatory drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a scientific statement from the American Heart Association?. ### Response: Use of nonsteroidal antiin-flammatory drugs.


Instruction: When did Circulation. 2007;115:1634–42.

Output: 238

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circulation. 2007;115:1634–42.. ### Response: 238.


Instruction: What did Gibson CM, Pride YB, Aylward PE, et al. study?

Output: Association of non-steroidal anti-inflammatory drugs with outcomes in patients with ST-segment elevation myocardial infarction treated with fibrinolytic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Gibson CM, Pride YB, Aylward PE, et al. study?. ### Response: Association of non-steroidal anti-inflammatory drugs with outcomes in patients with ST-segment elevation myocardial infarction treated with fibrinolytic therapy.


Instruction: What type of therapy is used to treat ST-segment elevation myocardial infarction?

Output: fibrinolytic therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is used to treat ST-segment elevation myocardial infarction?. ### Response: fibrinolytic therapy.


Instruction: What is the name of the prospective randomized trial of Celecoxib Integrated Safety versus Ibuprofen Or Naproxen?

Output: PRECISION

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective randomized trial of Celecoxib Integrated Safety versus Ibuprofen Or Naproxen?. ### Response: PRECISION.


Instruction: What is the name of the cardiovascular end point trial of nonsteroidal antiinflammatory agents in patients with arthritis?

Output: Prospective Randomized Evaluation of Celecoxib Integrated Safety versus Ibuprofen Or Naproxen (PRECISION),

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the cardiovascular end point trial of nonsteroidal antiinflammatory agents in patients with arthritis?. ### Response: Prospective Randomized Evaluation of Celecoxib Integrated Safety versus Ibuprofen Or Naproxen (PRECISION),.


Instruction: What is CT?

Output: computed tomography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CT?. ### Response: computed tomography.


Instruction: What is DW-MRI?

Output: diffusion-weighted magnetic resonance imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is DW-MRI?. ### Response: diffusion-weighted magnetic resonance imaging.


Instruction: FLAIR is fluid-attenuated inversion recovery.

Output: Table 8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: FLAIR is fluid-attenuated inversion recovery.. ### Response: Table 8.


Instruction: What is the modified Rankin Scale?

Output: mRS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the modified Rankin Scale?. ### Response: mRS.


Instruction: What is NCCT?

Output: noncontrast computed tomography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NCCT?. ### Response: noncontrast computed tomography.


Instruction: WHAT is the National Institutes of Health Stroke Scale called?

Output: NIHSS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: WHAT is the National Institutes of Health Stroke Scale called?. ### Response: NIHSS.


Instruction: What was considered the time when the patient was last known to be normal or at baseline neurological condition?

Output: the time of onset time

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was considered the time when the patient was last known to be normal or at baseline neurological condition?. ### Response: the time of onset time.


Instruction: What was the recommendation unchanged or reworded for clarity from 2015 IV Alteplase?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the recommendation unchanged or reworded for clarity from 2015 IV Alteplase?. ### Response: †.


Instruction: What is the maximum dose of AlteplaseInfuse?

Output: 90 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the maximum dose of AlteplaseInfuse?. ### Response: 90 mg.


Instruction: What is the maximum dose of Alteplase?

Output: 90 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the maximum dose of Alteplase?. ### Response: 90 mg.


Instruction: How much of the dose is given as a bolus over 1 min?

Output: 10%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the dose is given as a bolus over 1 min?. ### Response: 10%.


Instruction: What type of unit is used for monitoring if the patient develops severe headache, hypertension, nausea or vomiting?

Output: intensive care or stroke unit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of unit is used for monitoring if the patient develops severe headache, hypertension, nausea or vomiting?. ### Response: intensive care or stroke unit.


Instruction: What should you do if you have severe headache, acute hypertension, nausea, or vomiting?

Output: discontinue the infusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should you do if you have severe headache, acute hypertension, nausea, or vomiting?. ### Response: discontinue the infusion.


Instruction: If you have a worsening neurological examination, discontinue the IV alteplase infusion and obtain an emergency head CT scan?

Output: infusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: If you have a worsening neurological examination, discontinue the IV alteplase infusion and obtain an emergency head CT scan?. ### Response: infusion.


Instruction: How long is alteplase infusion?

Output: 2 h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is alteplase infusion?. ### Response: 2 h.


Instruction: How many h is altplasa infusion every 30 min for 6 h?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many h is altplasa infusion every 30 min for 6 h?. ### Response: 2.


Instruction: What is the frequency of BP measurements if SBP is >180 mm Hg?

Output: Increase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the frequency of BP measurements if SBP is >180 mm Hg?. ### Response: Increase.


Instruction: Antihypertensive medications to maintain BP at or below what levels?

Output: SBP is >180 mm Hg or if DBP is >105 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Antihypertensive medications to maintain BP at or below what levels?. ### Response: SBP is >180 mm Hg or if DBP is >105 mm Hg.


Instruction: Delay placement of nasogastric tubes, indwelling bladder catheters or intra-arterial pressure catheters if the patient can be safely managed without them.

Output: bladder catheters

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Delay placement of nasogastric tubes, indwelling bladder catheters or intra-arterial pressure catheters if the patient can be safely managed without them.. ### Response: bladder catheters.


Instruction: How long after IV alteplase before starting anticoagulants or antiplatelet agents?

Output: 24 h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after IV alteplase before starting anticoagulants or antiplatelet agents?. ### Response: 24 h.


Instruction: AIS indicates acute ischemic stroke.

Output: bladder catheters

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: AIS indicates acute ischemic stroke.. ### Response: bladder catheters.


Instruction: CT, computed tomography, DBP, diastolic blood pressure.

Output: bladder catheters

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: CT, computed tomography, DBP, diastolic blood pressure.. ### Response: bladder catheters.


Instruction: IV, intravenous, magnetic resonance imaging, and what else?

Output: MRI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: IV, intravenous, magnetic resonance imaging, and what else?. ### Response: MRI.


Instruction: What year was the 2013 American Heart Association, Inc.Downloaded from http://ahajournals.org by on April 28, 2023?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the 2013 American Heart Association, Inc.Downloaded from http://ahajournals.org by on April 28, 2023?. ### Response: 2013.


Instruction: What is NICE 2018?

Output: Chronic Heart Failure  Monitoring  © NICE 2018. All rights reserved

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE 2018?. ### Response: Chronic Heart Failure  Monitoring  © NICE 2018. All rights reserved.


Instruction: What is the name of the study?

Output: Al-Sutari

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study?. ### Response: Al-Sutari.


Instruction: How old is the participant?

Output: 72 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old is the participant?. ### Response: 72 years.


Instruction: What is the mean age of people with systolic HF?

Output: 58 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the mean age of people with systolic HF?. ### Response: 58 years.


Instruction: How old is the average age of the population with a HF diagnosis?

Output: 68 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old is the average age of the population with a HF diagnosis?. ### Response: 68 years.


Instruction: What type of mortality is the most common cause of death in Finland?

Output: All-cause

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of mortality is the most common cause of death in Finland?. ### Response: All-cause.


Instruction: How many people with symptomatic HF (NYHA Class II or greater) were telemonitored in 2008372?

Output: 121

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people with symptomatic HF (NYHA Class II or greater) were telemonitored in 2008372?. ### Response: 121.


Instruction: How old was the average age of the people in the United States?

Output: 72 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old was the average age of the people in the United States?. ### Response: 72 years.


Instruction: What is the percentage of all-cause mortality?

Output: 60/40

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the percentage of all-cause mortality?. ### Response: 60/40.


Instruction: How many deaths in Canada are associated with all-cause mortality?

Output: 74/26

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many deaths in Canada are associated with all-cause mortality?. ### Response: 74/26.


Instruction: How many cases of hospitalisation are related to all causes of mortality in Canada?

Output: 74/26

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many cases of hospitalisation are related to all causes of mortality in Canada?. ### Response: 74/26.


Instruction: What is the name of the summary of studies included in the update of the Cochrane review?

Output: Table 92

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the summary of studies included in the update of the Cochrane review?. ### Response: Table 92.


Instruction: How many people with heart failure attended a cardiac clinic?

Output: n=144

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people with heart failure attended a cardiac clinic?. ### Response: n=144.


Instruction: What was the mean age of the people attending the cardiac clinic of an educational hospita l?

Output: 64.78

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean age of the people attending the cardiac clinic of an educational hospita l?. ### Response: 64.78.


Instruction: What is the mean age?

Output: 72 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the mean age?. ### Response: 72 years.


Instruction: What percentage of the population is affected by all causes of mortality?

Output: 60/40

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the population is affected by all causes of mortality?. ### Response: 60/40.


Instruction: ANGIOTENSIN -RECEPTOR BLOCKERSCLASS I1.ARBs are recommended in patients with HF rEF withcurrent or prior symptoms who are ACE inhibitor intolerant to reduce what?

Output: morbidity and mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ANGIOTENSIN -RECEPTOR BLOCKERSCLASS I1.ARBs are recommended in patients with HF rEF withcurrent or prior symptoms who are ACE inhibitor intolerant to reduce what?. ### Response: morbidity and mortality.


Instruction: What is a first-line therapy for patients withHFrEF?

Output: ARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a first-line therapy for patients withHFrEF?. ### Response: ARBs.


Instruction: When were ARBs unless contraindicated?

Output: 190– 195

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When were ARBs unless contraindicated?. ### Response: 190– 195.


Instruction: What may be considered in persistentlysymptomatic patients with HF rEF who are already being treated with an ACE inhibitor?

Output: Addition of an ARB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered in persistentlysymptomatic patients with HF rEF who are already being treated with an ACE inhibitor?. ### Response: Addition of an ARB.


Instruction: What is not indicated or tolerated?

Output: an aldosterone antagonist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not indicated or tolerated?. ### Response: an aldosterone antagonist.


Instruction: What is potentially harmful for patients withHFrEF?

Output: Routine combined use of an ACE inhibitor, ARB, and aldo-sterone antagonist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is potentially harmful for patients withHFrEF?. ### Response: Routine combined use of an ACE inhibitor, ARB, and aldo-sterone antagonist.


Instruction: What is the level of evidence for patients withHFrEF?

Output: A

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the level of evidence for patients withHFrEF?. ### Response: A.


Instruction: What is recommended for all patients with current or priorsymptoms of HFr EF, unless contraindicated?

Output: Use of 1 of the 3 beta blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for all patients with current or priorsymptoms of HFr EF, unless contraindicated?. ### Response: Use of 1 of the 3 beta blockers.


Instruction: How many beta blockers have been proven to reduce mortality?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many beta blockers have been proven to reduce mortality?. ### Response: 3.


Instruction: What is contraindicated to reduce morbidity and mortality?

Output: ARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is contraindicated to reduce morbidity and mortality?. ### Response: ARBs.


Instruction: What is the level of evidence for aldosterone receptor antagonists?

Output: B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the level of evidence for aldosterone receptor antagonists?. ### Response: B.


Instruction: What percentage of LVEF is required to reduce morbidity and mortality?

Output: 35%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of LVEF is required to reduce morbidity and mortality?. ### Response: 35%.


Instruction: Patients with NYHA class II HF should have a history of what?

Output: prior cardiovascular hospitalization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with NYHA class II HF should have a history of what?. ### Response: prior cardiovascular hospitalization.


Instruction: What should be 2.5 mg/dL or less in men?

Output: Creatinines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be 2.5 mg/dL or less in men?. ### Response: Creatinines.


Instruction: What should be less than5.0 mEq/L?

Output: potassium

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be less than5.0 mEq/L?. ### Response: potassium.


Instruction: What is the risk of hyperkalemia and renal ficiency?

Output: life-threatening

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of hyperkalemia and renal ficiency?. ### Response: life-threatening.


Instruction: To minimize risk of hyperkalemia and renal insuf ficiency (181,182,197)?

Output: Careful monitoring of potassium, renalfunction, and diuretic dosing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: To minimize risk of hyperkalemia and renal insuf ficiency (181,182,197)?. ### Response: Careful monitoring of potassium, renalfunction, and diuretic dosing.


Instruction: What is recommended to reduce morbidity and mortality following an acute MI?

Output: Aldosterone receptor antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended to reduce morbidity and mortality following an acute MI?. ### Response: Aldosterone receptor antagonists.


Instruction: What is the name of the class of aldosterone receptor antagonists?

Output: CLASS I1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the class of aldosterone receptor antagonists?. ### Response: CLASS I1.


Instruction: What is a life-threatening hyperkalemia or renal insuf ficiency?

Output: serum creatinine is greater than

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a life-threatening hyperkalemia or renal insuf ficiency?. ### Response: serum creatinine is greater than.


Instruction: What type of patients had creatinine >30 mL/min and K+ 5.0 mEq/dL?

Output: NYHA class II-IV

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of patients had creatinine >30 mL/min and K+ 5.0 mEq/dL?. ### Response: NYHA class II-IV.


Instruction: For persistent symptomaticAfrican Americans,NYHA class III-IVClass I, LOE AACEI or ARB ANDBeta BlockerClass I or LOE CLoop DiureticsClass I?

Output: LOE A

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For persistent symptomaticAfrican Americans,NYHA class III-IVClass I, LOE AACEI or ARB ANDBeta BlockerClass I or LOE CLoop DiureticsClass I?. ### Response: LOE A.


Instruction: How many Hypertension events occurred in high-risk patients in June 2015?

Output: 1400

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many Hypertension events occurred in high-risk patients in June 2015?. ### Response: 1400.


Instruction: What is the name of the study that investigated hypertension in high risk patients?

Output: Heart Outcomes Prevention Evaluation Study Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated hypertension in high risk patients?. ### Response: Heart Outcomes Prevention Evaluation Study Investigators.


Instruction: In what year was the N Engl J Med published?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was the N Engl J Med published?. ### Response: 2010.


Instruction: What did the SA VE Investigators study?

Output: Effect of captopril on mortality and morbid-ity in patients with left ventricular dysfunction after myocardial infarc-tion: results of the Survival and Ventricular Enlargement trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the SA VE Investigators study?. ### Response: Effect of captopril on mortality and morbid-ity in patients with left ventricular dysfunction after myocardial infarc-tion: results of the Survival and Ventricular Enlargement trial.


Instruction: What was the effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction?

Output: Effect of captopril on mortality and morbid-ity in patients with left ventricular dysfunction after myocardial infarc-tion: results of the Survival and Ventricular Enlargement trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction?. ### Response: Effect of captopril on mortality and morbid-ity in patients with left ventricular dysfunction after myocardial infarc-tion: results of the Survival and Ventricular Enlargement trial.


Instruction: What is the SA VE Investigators trial?

Output: Survival and Ventricular Enlargement trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the SA VE Investigators trial?. ### Response: Survival and Ventricular Enlargement trial.


Instruction: What was the N Engl J Med. 1992;327:669–677?

Output: Survival and Ventricular Enlargement trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the N Engl J Med. 1992;327:669–677?. ### Response: Survival and Ventricular Enlargement trial.


Instruction: What is the EUROPA study?

Output: randomised, double-blind, placebo-controlled, multicentre trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the EUROPA study?. ### Response: randomised, double-blind, placebo-controlled, multicentre trial.


Instruction: What is TROPHY?

Output: Trial of Preventing Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is TROPHY?. ### Response: Trial of Preventing Hypertension.


Instruction: What does TROPHY stand for?

Output: Trial of Preventing Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does TROPHY stand for?. ### Response: Trial of Preventing Hypertension.


Instruction: What is the name of the study that investigated the feasibility of treating prehypertension with an angiotensin-receptor blocker?

Output: Trial of Preventing Hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the feasibility of treating prehypertension with an angiotensin-receptor blocker?. ### Response: Trial of Preventing Hypertension.


Instruction: Who is the ACCORD Study Group?

Output: Cushman WC

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the ACCORD Study Group?. ### Response: Cushman WC.


Instruction: What does intensive blood pressure control have on type 2 diabetes mellitus?

Output: Effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does intensive blood pressure control have on type 2 diabetes mellitus?. ### Response: Effects.


Instruction: What is the N Engl J Med. 2010:362:1575–1585?

Output: Effects of intensive blood-pressure control in type 2 diabetes mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the N Engl J Med. 2010:362:1575–1585?. ### Response: Effects of intensive blood-pressure control in type 2 diabetes mellitus.


Instruction: Kannel WB. Some lessons in cardiovascular epidemiology from where?

Output: Framingham

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Kannel WB. Some lessons in cardiovascular epidemiology from where?. ### Response: Framingham.


Instruction: What did Framingham learn from?

Output: cardiovascular epidemiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Framingham learn from?. ### Response: cardiovascular epidemiology.


Instruction: What is the acronym for Kidney Disease: Improving Global Outcomes?

Output: KDIGO

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Kidney Disease: Improving Global Outcomes?. ### Response: KDIGO.


Instruction: What is the name of the NCEP Expert Panel on the Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults?

Output: National Cholesterol Education Program

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the NCEP Expert Panel on the Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults?. ### Response: National Cholesterol Education Program.


Instruction: What is NCEP's final report on the detection, evaluation, and treatment of high blood cholesterol in adults called?

Output: Adult Treatment Panel III

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NCEP's final report on the detection, evaluation, and treatment of high blood cholesterol in adults called?. ### Response: Adult Treatment Panel III.


Instruction: What does MESA stand for?

Output: Multi-Ethnic Study of Atherosclerosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does MESA stand for?. ### Response: Multi-Ethnic Study of Atherosclerosis.


Instruction: What is the name of the multi-ethnic study of atherosclerosis?

Output: MESA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multi-ethnic study of atherosclerosis?. ### Response: MESA.


Instruction: When was the J Am Coll Cardiol.56:1506-1512?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol.56:1506-1512?. ### Response: 2010.


Instruction: What is the multi-ethnic study of atherosclerosis?

Output: MESA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the multi-ethnic study of atherosclerosis?. ### Response: MESA.