Instruction: What should be started as soon as possible in comatose patients with STEMI and out-of-hospital cardiac arrest caused by ventricular fibrillation?

Output: Therapeutic hypothermia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be started as soon as possible in comatose patients with STEMI and out-of-hospital cardiac arrest caused by ventricular fibrillation?. ### Response: Therapeutic hypothermia.


Instruction: What is VT?

Output: pulseless ventricular tachycar -dia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is VT?. ### Response: pulseless ventricular tachycar -dia.


Instruction: What do women with hyper tension who are pregnant not expect to do?

Output: change practice significant ly

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do women with hyper tension who are pregnant not expect to do?. ### Response: change practice significant ly.


Instruction: What are t hese r ecommendations not expecting to change?

Output: practice significant ly

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are t hese r ecommendations not expecting to change?. ### Response: practice significant ly.


Instruction: What is t he aim of the evidence and the committee's discussion?

Output: treatment initiation t hresholds f or gestational h yper tension in pr egnancy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is t he aim of the evidence and the committee's discussion?. ### Response: treatment initiation t hresholds f or gestational h yper tension in pr egnancy.


Instruction: What is the aim of interventions for chronic hyper tension?

Output: diagnosis and management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the aim of interventions for chronic hyper tension?. ### Response: diagnosis and management.


Instruction: Why did the c ommi ttee make the r ecommenda tions?

Output: this is applicable t o women wit h gestational h yper tension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why did the c ommi ttee make the r ecommenda tions?. ### Response: this is applicable t o women wit h gestational h yper tension.


Instruction: What was updat ed the table fr om t he management of pregnancy wit h gestational hyper tension?

Output: pr evious guideline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was updat ed the table fr om t he management of pregnancy wit h gestational hyper tension?. ### Response: pr evious guideline.


Instruction: Management of pregnancy wit h gestational h yper tension?

Output: NICE diagnostics guidance on placental growth factor (PlGF) t esting  as this is applicable t o women

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Management of pregnancy wit h gestational h yper tension?. ### Response: NICE diagnostics guidance on placental growth factor (PlGF) t esting  as this is applicable t o women.


Instruction: There was v ery little evidence a vailable on treatment initiation t hresholds f or what?

Output: gestational h yper tension in pr egnancy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There was v ery little evidence a vailable on treatment initiation t hresholds f or what?. ### Response: gestational h yper tension in pr egnancy.


Instruction: What is CHIPS?

Output: Contr ol of Hyper tension in Pregnancy Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CHIPS?. ### Response: Contr ol of Hyper tension in Pregnancy Study.


Instruction: What was evidence f or tar get blood pr ssur e levels fr om t he large CHIPS trial?

Output: Ther e

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was evidence f or tar get blood pr ssur e levels fr om t he large CHIPS trial?. ### Response: Ther e.


Instruction: What did the committ ee make r ecommendations based on?

Output: using t he values specified in t he recent Contr ol of Hyper tension in Pregnancy Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committ ee make r ecommendations based on?. ### Response: using t he values specified in t he recent Contr ol of Hyper tension in Pregnancy Study.


Instruction: What is PlGF?

Output: placental growth factor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PlGF?. ### Response: placental growth factor.


Instruction: What is t o women wit h gestational h yper tension?

Output: placental growth factor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is t o women wit h gestational h yper tension?. ### Response: placental growth factor.


Instruction: What did the committee w ere awar e of?

Output: t he link betw een gestational h yper tension and bot h pre-existing and gestational diabet es

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee w ere awar e of?. ### Response: t he link betw een gestational h yper tension and bot h pre-existing and gestational diabet es.


Instruction: What was a resear ch recommendation made at the beginning of the guideline?

Output: Ther e was no e vidence on f etal monit oring in gestational h yper tension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a resear ch recommendation made at the beginning of the guideline?. ### Response: Ther e was no e vidence on f etal monit oring in gestational h yper tension.


Instruction: What was the NICE guideline on diabet es in pregnancy?

Output: placental growth factor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the NICE guideline on diabet es in pregnancy?. ### Response: placental growth factor.


Instruction: How do the r ecommendations mig ht affect practice in man y unit s?

Output: not expect ed to change practice significant ly

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do the r ecommendations mig ht affect practice in man y unit s?. ### Response: not expect ed to change practice significant ly.


Instruction: How do t he committee make a research recommendation?

Output: using t he values specified in t he recent Contr ol of Hyper tension in Pregnancy Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How do t he committee make a research recommendation?. ### Response: using t he values specified in t he recent Contr ol of Hyper tension in Pregnancy Study.


Instruction: Hyper tension in pregnancy: diagnosis and management (NG133) NICE 2023.

Output: All right s reserved

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hyper tension in pregnancy: diagnosis and management (NG133) NICE 2023.. ### Response: All right s reserved.


Instruction: What is the last updat ed 17 April 2023?

Output: Page 48of 59

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the last updat ed 17 April 2023?. ### Response: Page 48of 59.


Instruction: How many RCTs were included in the included studies?

Output: 290

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs were included in the included studies?. ### Response: 290.


Instruction: How many CKD narrative reviews did the systematic reviews have?

Output: 7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many CKD narrative reviews did the systematic reviews have?. ### Response: 7.


Instruction: What were the general population narrative reviews for?

Output: general population cost-effectiveness reviews

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the general population narrative reviews for?. ### Response: general population cost-effectiveness reviews.


Instruction: How many general population narrative reviews did the Cochrane Kidney and Transplant Registry have?

Output: 20

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many general population narrative reviews did the Cochrane Kidney and Transplant Registry have?. ### Response: 20.


Instruction: How many citations were excluded from the systematic reviews of blood pressuremeasurement techniques?

Output: 524

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many citations were excluded from the systematic reviews of blood pressuremeasurement techniques?. ### Response: 524.


Instruction: What is CKD, chronic kidney disease?

Output: CKD, chronic kidney disease; RCT, randomized controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CKD, chronic kidney disease?. ### Response: CKD, chronic kidney disease; RCT, randomized controlled trial.


Instruction: What is CKD?

Output: chronic kidney disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CKD?. ### Response: chronic kidney disease.


Instruction: What is RCT?

Output: randomized controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is RCT?. ### Response: randomized controlled trial.


Instruction: How close to the estimate of the effect is the true effect likely to be?

Output: B Moderate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How close to the estimate of the effect is the true effect likely to be?. ### Response: B Moderate.


Instruction: What is a possibility that the real effect is substantially different from the estimate?

Output: C Low

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a possibility that the real effect is substantially different from the estimate?. ### Response: C Low.


Instruction: What is the estimate of the effect?

Output: Very low

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the estimate of the effect?. ### Response: Very low.


Instruction: What is very low The estimate of effect is very uncertain and often far from the true effect.

Output: D

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is very low The estimate of effect is very uncertain and often far from the true effect.. ### Response: D.


Instruction: What is NT -proBNP?

Output: N -terminal pro -B-type natriuretic peptide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NT -proBNP?. ### Response: N -terminal pro -B-type natriuretic peptide.


Instruction: What is N -terminal pro -B-type natriuretic peptide?

Output: NT -proBNP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is N -terminal pro -B-type natriuretic peptide?. ### Response: NT -proBNP.


Instruction: What is optimisation protocol only for people under 75 who have heart failure with reduced ejection fraction and an eGFR above 60 ml/min/1.73 m2?

Output: specialist care setting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is optimisation protocol only for people under 75 who have heart failure with reduced ejection fraction and an eGFR above 60 ml/min/1.73 m2?. ### Response: specialist care setting.


Instruction: Monitoring using other biomarkers or repeated cardiac imaging (echocardiography or cardiac MRI)?

Output: absence of evidence on the clinical effectiveness  of monitoring using other troponin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Monitoring using other biomarkers or repeated cardiac imaging (echocardiography or cardiac MRI)?. ### Response: absence of evidence on the clinical effectiveness  of monitoring using other troponin.


Instruction: What is another term for echocardiography or cardiac MRI?

Output: repeated cardiac imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for echocardiography or cardiac MRI?. ### Response: repeated cardiac imaging.


Instruction: What did the committee agree not to do?

Output: make no recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee agree not to do?. ### Response: make no recommendation.


Instruction: What is the added value of cardiac MRI in the diagnosis of heart failure and its aetiology?

Output: £3,304 per QALY gained

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the added value of cardiac MRI in the diagnosis of heart failure and its aetiology?. ### Response: £3,304 per QALY gained.


Instruction: What would be necessary before developing an evidence base for the use of cardiac imaging as a monitoring tool?

Output: further research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would be necessary before developing an evidence base for the use of cardiac imaging as a monitoring tool?. ### Response: further research.


Instruction: What is used as a monitoring tool?

Output: cardiac imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used as a monitoring tool?. ### Response: cardiac imaging.


Instruction: What is the trade-off between net clinical effects and cos ts?

Output: more effective and less costly

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the trade-off between net clinical effects and cos ts?. ### Response: more effective and less costly.


Instruction: How many economic evaluations were identified and included in this review?

Output: Three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many economic evaluations were identified and included in this review?. ### Response: Three.


Instruction: What did the Austrian cost -utility analysis assess patients with heart failure who ha d recently been discharged after a heart failure hospitalisation?

Output: NP monitoring to usual care.  The Austrian cost -utility analysis assessed patients with heart failure who ha d recently been discharged after a heart failure hospitalisation. The study compared usual care by a primary care physician as well as usual care by a nurse -led multidisciplinary team (MDT) to intensive NP monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Austrian cost -utility analysis assess patients with heart failure who ha d recently been discharged after a heart failure hospitalisation?. ### Response: NP monitoring to usual care.  The Austrian cost -utility analysis assessed patients with heart failure who ha d recently been discharged after a heart failure hospitalisation. The study compared usual care by a primary care physician as well as usual care by a nurse -led multidisciplinary team (MDT) to intensive NP monitoring.


Instruction: What type of care was compared to usual care by a primary care physician and a nurse -led multidisciplinary team?

Output: intensive NP monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of care was compared to usual care by a primary care physician and a nurse -led multidisciplinary team?. ### Response: intensive NP monitoring.


Instruction: What is MDT?

Output: nurse -led multidisciplinary team

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is MDT?. ### Response: nurse -led multidisciplinary team.


Instruction: What does MDT stand for?

Output: multidisciplinary team

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does MDT stand for?. ### Response: multidisciplinary team.


Instruction: How are Mortality and Hospitalisation rates determined?

Output: economic evaluation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are Mortality and Hospitalisation rates determined?. ### Response: economic evaluation.


Instruction: What is effective and less costly?

Output: NP monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is effective and less costly?. ### Response: NP monitoring.


Instruction: What does NP monitoring dominate?

Output: usual care in the community and the nurse -led MDT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does NP monitoring dominate?. ### Response: usual care in the community and the nurse -led MDT.


Instruction: How many studies were included in the clinical trial?

Output: 13

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were included in the clinical trial?. ### Response: 13.


Instruction: How many studies were included in the clinical review?

Output: 13

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were included in the clinical review?. ### Response: 13.


Instruction: What is unlikely to reflect the best estimate of the effect of NP monitoring?

Output: the relative effect of NP monitoring was taken from only one of 13 studies included in the clinical review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is unlikely to reflect the best estimate of the effect of NP monitoring?. ### Response: the relative effect of NP monitoring was taken from only one of 13 studies included in the clinical review.


Instruction: What did the UK cost -utility analysis compare usual care in the community and/or usual care through specialist clinical assessment to?

Output: natriuretic peptide monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the UK cost -utility analysis compare usual care in the community and/or usual care through specialist clinical assessment to?. ### Response: natriuretic peptide monitoring.


Instruction: How many population groups did the model assess?

Output: two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many population groups did the model assess?. ### Response: two.


Instruction: Patients with heart failure due to LVSD were assessed by what model?

Output: Austrian cost -utility analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with heart failure due to LVSD were assessed by what model?. ### Response: Austrian cost -utility analysis.


Instruction: What is NP monitoring cost effective for patients with chronic heart failure and LVSD at any age?

Output: £20,000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NP monitoring cost effective for patients with chronic heart failure and LVSD at any age?. ### Response: £20,000.


Instruction: How much does ICER: £3,304 per QALY gained?

Output: cost effective for patients with chronic heart failure and LVSD at any age compared to specialist management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much does ICER: £3,304 per QALY gained?. ### Response: cost effective for patients with chronic heart failure and LVSD at any age compared to specialist management.


Instruction: What was the cost per QALY gained per ICER?

Output: £3,304

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the cost per QALY gained per ICER?. ### Response: £3,304.


Instruction: How much was the probability that NP monitoring is cost effective at the £20,000 threshold?

Output: 99%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much was the probability that NP monitoring is cost effective at the £20,000 threshold?. ### Response: 99%..


Instruction: What was found for patients with CHF?

Output: Similar resul ts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was found for patients with CHF?. ### Response: Similar resul ts.


Instruction: What is the Journal of the American College of Cardiology?

Output: 1959 -66 96

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Journal of the American College of Cardiology?. ### Response: 1959 -66 96.


Instruction: What is a heart failure self-management program for patients of all literacy levels?

Output: a randomized, controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a heart failure self-management program for patients of all literacy levels?. ### Response: a randomized, controlled trial.


Instruction: When did BMC Health Services Research publish?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did BMC Health Services Research publish?. ### Response: 2006.


Instruction: What is the ISRCTN11535170?

Output: A heart failure self-management program for patients of all literacy levels: a randomized, controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ISRCTN11535170?. ### Response: A heart failure self-management program for patients of all literacy levels: a randomized, controlled trial.


Instruction: When was BMC Health Services Research published?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was BMC Health Services Research published?. ### Response: 2006.


Instruction: What was the name of the group that investigated the effect of digoxin on mortality and morbidity in heart failure patients?

Output: Digitalis Investigation Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the group that investigated the effect of digoxin on mortality and morbidity in heart failure patients?. ### Response: Digitalis Investigation Group.


Instruction: What effect did crossover have on mortality in a randomized study of revascularization in patients with systolic heart failure and coronary artery disease?

Output: Influence of crossover on mortality in a randomized study of revascularization in patients with systolic heart failure and coronary artery disease. Circulation: Heart Failure. 2013; 6(3):443 -50

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What effect did crossover have on mortality in a randomized study of revascularization in patients with systolic heart failure and coronary artery disease?. ### Response: Influence of crossover on mortality in a randomized study of revascularization in patients with systolic heart failure and coronary artery disease. Circulation: Heart Failure. 2013; 6(3):443 -50.


Instruction: What is the Circulation: Heart Failure. 2013; 6(3):443 -50?

Output: Influence of crossover on mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Circulation: Heart Failure. 2013; 6(3):443 -50?. ### Response: Influence of crossover on mortality.


Instruction: What concerns were raised about publication bias?

Output: imprecision in theevidence review results

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What concerns were raised about publication bias?. ### Response: imprecision in theevidence review results.


Instruction: Data were benchmarked against what?

Output: optimal informationsize

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Data were benchmarked against what?. ### Response: optimal informationsize.


Instruction: How many studies did there only exist?

Output: 148

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies did there only exist?. ### Response: 148.


Instruction: What is the final grade for the quality of the evidence for an outcome?

Output: high, moderate, low, or verylow

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the final grade for the quality of the evidence for an outcome?. ### Response: high, moderate, low, or verylow.


Instruction: What could be evidence for an outcome high, moderate, low, or verylow?

Output: Theﬁnal grade

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could be evidence for an outcome high, moderate, low, or verylow?. ### Response: Theﬁnal grade.


Instruction: For observational studies and other study types, it is possible for the quality of the evidence to be upgraded from a ratingof low quality according to what criteria?

Output: speci ﬁed criteria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For observational studies and other study types, it is possible for the quality of the evidence to be upgraded from a ratingof low quality according to what criteria?. ### Response: speci ﬁed criteria.


Instruction: What is the GRADE approach for rating quality of the evidence?

Output: SoF table

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the GRADE approach for rating quality of the evidence?. ### Response: SoF table.


Instruction: What are the summaries of findings tables called?

Output: SoF) tables

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the summaries of findings tables called?. ### Response: SoF) tables.


Instruction: How were the SoF tables developed?

Output: to include a description of the population and the intervention andcomparator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How were the SoF tables developed?. ### Response: to include a description of the population and the intervention andcomparator.


Instruction: How were the SoF tables generated?

Output: usingMAGICapp

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How were the SoF tables generated?. ### Response: usingMAGICapp.


Instruction: What was the purpose of theMAGICapp?

Output: to supportguideline development

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the purpose of theMAGICapp?. ### Response: to supportguideline development.


Instruction: How was the grading of the quality of the evidence provided?

Output: high, moderate, low, or verylow

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the grading of the quality of the evidence provided?. ### Response: high, moderate, low, or verylow.


Instruction: What is the online software application designed to support?

Output: guideline development

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the online software application designed to support?. ### Response: guideline development.


Instruction: Where are the recommendations available?

Output: DataSupplement Appendix C and Appendix D

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are the recommendations available?. ### Response: DataSupplement Appendix C and Appendix D.


Instruction: Who drafted the recommendations?

Output: Work Group Co-Chairs and Work Group members

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who drafted the recommendations?. ### Response: Work Group Co-Chairs and Work Group members.


Instruction: When were the recommendations revised?

Output: January 2019

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When were the recommendations revised?. ### Response: January 2019.


Instruction: When was the meeting held in New Orleans, LA, USA?

Output: January 2019

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the meeting held in New Orleans, LA, USA?. ### Response: January 2019.


Instruction: What was the final draft sent for?

Output: externalpublic review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the final draft sent for?. ### Response: externalpublic review.


Instruction: Who provided feedback on initial and final drafts?

Output: All Work Groupmembers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who provided feedback on initial and final drafts?. ### Response: All Work Groupmembers.


Instruction: Who provided feedback on initial and final drafts of therecommendation statement and guideline text?

Output: Work Group Co-Chairs and Work

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who provided feedback on initial and final drafts of therecommendation statement and guideline text?. ### Response: Work Group Co-Chairs and Work.


Instruction: Who approved the final version of the guideline?

Output: All Work Groupmembers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who approved the final version of the guideline?. ### Response: All Work Groupmembers.


Instruction: How many study reports were retrieved from the Cochrane Kidney and Transplant Registry in 2020?

Output: 6156

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many study reports were retrieved from the Cochrane Kidney and Transplant Registry in 2020?. ### Response: 6156.


Instruction: How many RCTs included dietary protein?

Output: 21

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs included dietary protein?. ### Response: 21.


Instruction: What was included in the 21 RCT's?

Output: Dietary protein

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was included in the 21 RCT's?. ### Response: Dietary protein.


Instruction: Which RCT included exercise interventions?

Output: 11 RCTs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which RCT included exercise interventions?. ### Response: 11 RCTs.


Instruction: How many RCTs were conducted in adults with CKD?

Output: 76

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs were conducted in adults with CKD?. ### Response: 76.


Instruction: What type of therapy was used in transplant recipients?

Output: Antihypertensive

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy was used in transplant recipients?. ### Response: Antihypertensive.


Instruction: In addition to blood pressure targets in children, how many studies were done in children?

Output: 1 RCT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In addition to blood pressure targets in children, how many studies were done in children?. ### Response: 1 RCT.


Instruction: How many RCTs were conducted in children?

Output: 1 RCT• Antihypertensive therapy in children – 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs were conducted in children?. ### Response: 1 RCT• Antihypertensive therapy in children – 2.


Instruction: What was the number of recipients of the RCT?

Output: 82

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the number of recipients of the RCT?. ### Response: 82.


Instruction: How many randomized controlled trials were conducted?

Output: 21

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many randomized controlled trials were conducted?. ### Response: 21.


Instruction: What is the name of the ACCF/AHA Task Force onPractice Guidelines?

Output: •AstraZeneca

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the ACCF/AHA Task Force onPractice Guidelines?. ### Response: •AstraZeneca.


Instruction: Who is a content reviewer?

Output: John D.Rutherford

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a content reviewer?. ### Response: John D.Rutherford.


Instruction: What is the name of the 2010 peer review of a malpractice claim?

Output: MathewWilliamsContent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2010 peer review of a malpractice claim?. ### Response: MathewWilliamsContent.


Instruction: What does the table below represent the relationships of reviewers with industry and other entities?

Output: Relationships in this table are modest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the table below represent the relationships of reviewers with industry and other entities?. ### Response: Relationships in this table are modest.


Instruction: What percentage of the voting stock or share of a business is a person deemed to have a significant interest in?

Output: /H113505%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the voting stock or share of a business is a person deemed to have a significant interest in?. ### Response: /H113505%.


Instruction: How much of the fair market value of the business entity does the person deems to be significant?

Output: /H11350$10 000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the fair market value of the business entity does the person deems to be significant?. ### Response: /H11350$10 000.


Instruction: What is the fair market value of the business entity?

Output: $10 000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the fair market value of the business entity?. ### Response: $10 000.


Instruction: How much of the person's gross income for the previous year is received from a business entity by a person?

Output: 5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the person's gross income for the previous year is received from a business entity by a person?. ### Response: 5%.


Instruction: What is a relationship considered to be if it is less than significant?

Output: mo dest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a relationship considered to be if it is less than significant?. ### Response: mo dest.


Instruction: What are relationships that exist with no financial benefit included for the purpose of tr ansparency?

Output: Significant relationship

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are relationships that exist with no financial benefit included for the purpose of tr ansparency?. ### Response: Significant relationship.


Instruction: Relationships in this table are modest unless what is noted?

Output: otherwise noted

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Relationships in this table are modest unless what is noted?. ### Response: otherwise noted.


Instruction: Names are listed in alphabetical order within each category of what?

Output: review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Names are listed in alphabetical order within each category of what?. ### Response: review.


Instruction: What does ACCF/AHA say a person has a relevant relationship with?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ACCF/AHA say a person has a relevant relationship with?. ### Response: American Heart Association.


Instruction: What does the relationship or interest relate to?

Output: the same or similar subject matter, intellectual propertyor asset, topic, or issue addressed in the document

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the relationship or interest relate to?. ### Response: the same or similar subject matter, intellectual propertyor asset, topic, or issue addressed in the document.


Instruction: What does the person or a member of the person’s household have a reasonable potential for as a result of the relationship exist?

Output: financial, professional or other personal gain or loss

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the person or a member of the person’s household have a reasonable potential for as a result of the relationship exist?. ### Response: financial, professional or other personal gain or loss.


Instruction: What is the acronym for American Association for Thoracic Surgery?

Output: AATS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for American Association for Thoracic Surgery?. ### Response: AATS.


Instruction: What does ACCF stand for?

Output: American College of Cardiology Foundation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ACCF stand for?. ### Response: American College of Cardiology Foundation.


Instruction: AHA stands for what?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: AHA stands for what?. ### Response: American Heart Association.


Instruction: What is PCI?

Output: percutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PCI?. ### Response: percutaneous coronary intervention.


Instruction: What is ST-elevation my ocardial infarction?

Output: STEMI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ST-elevation my ocardial infarction?. ### Response: STEMI.


Instruction: Which abbreviation does STS stand for?

Output: Society of Thoracic Surgeons

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which abbreviation does STS stand for?. ### Response: Society of Thoracic Surgeons.


Instruction: The quality of the evidence for thromboendarterectomy in patients with CTEPH has not improved what?

Output: central disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The quality of the evidence for thromboendarterectomy in patients with CTEPH has not improved what?. ### Response: central disease.


Instruction: What did the AT10 panel decide was too restrictive?

Output: forthromboendarterectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the AT10 panel decide was too restrictive?. ### Response: forthromboendarterectomy.


Instruction: Why is it now often possible to removeorganized thrombi from peripheral pulmonary arteries?

Output: improvements insurgical technique

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is it now often possible to removeorganized thrombi from peripheral pulmonary arteries?. ### Response: improvements insurgical technique.


Instruction: In patients with inoperable CTEPH or persistentpulmonary hypertension, there is new evidence from a randomized trial that pulmonary vasodilator therapymay be of bene fit?

Output: 163

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with inoperable CTEPH or persistentpulmonary hypertension, there is new evidence from a randomized trial that pulmonary vasodilator therapymay be of bene fit?. ### Response: 163.


Instruction: Why do we no longer identify central disease as a selection factor forthromboendarterectomy in patients with CTEPH?

Output: For these reasons

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why do we no longer identify central disease as a selection factor forthromboendarterectomy in patients with CTEPH?. ### Response: For these reasons.


Instruction: Who should beassessed by a team with expertise in the evaluation andmanagement ofpulmonary hypertension?

Output: patients with CTEPH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should beassessed by a team with expertise in the evaluation andmanagement ofpulmonary hypertension?. ### Response: patients with CTEPH.


Instruction: What is the term for chronic thromboem-bolic pulmonary hypertension?

Output: CTEPH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for chronic thromboem-bolic pulmonary hypertension?. ### Response: CTEPH.


Instruction: What is a grade 2C pulmonarythromboendarterectomy?

Output: no

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a grade 2C pulmonarythromboendarterectomy?. ### Response: no.


Instruction: Patients with CTEPH should be evaluated by whom?

Output: ateam

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with CTEPH should be evaluated by whom?. ### Response: ateam.


Instruction: What is the VA/DoD Clinical Practice Guideline for the Diagnosis and Management of Hypertension in the Primary Care Setting?

Output: Page 32 of 134

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for the Diagnosis and Management of Hypertension in the Primary Care Setting?. ### Response: Page 32 of 134.


Instruction: What is more readily available than ABPM and requires fewer resources?

Output: HBPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is more readily available than ABPM and requires fewer resources?. ### Response: HBPM.


Instruction: What type of education is recommended?

Output: careful patient education

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of education is recommended?. ### Response: careful patient education.


Instruction: What is needed to evaluate the effectiveness of using out-of-office bloo d pressure to manage HTN?

Output: More research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed to evaluate the effectiveness of using out-of-office bloo d pressure to manage HTN?. ### Response: More research.


Instruction: What would improve cardiovascular morbidity and mortality in hypertensive individuals?

Output: treating to ABPM or HBPM guided blood pressure goals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would improve cardiovascular morbidity and mortality in hypertensive individuals?. ### Response: treating to ABPM or HBPM guided blood pressure goals.


Instruction: What is Monitoring Recommendation 5 among patients treated for hypertension?

Output: home blood pressure self -monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Monitoring Recommendation 5 among patients treated for hypertension?. ### Response: home blood pressure self -monitoring.


Instruction: Home blood pressure self monitoring has been shown to improve SB P and DBP control when paired with what?

Output: a co -intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Home blood pressure self monitoring has been shown to improve SB P and DBP control when paired with what?. ### Response: a co -intervention.


Instruction: How many SRs were found in our evidence review?

Output: two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many SRs were found in our evidence review?. ### Response: two.


Instruction: How many SRs of RCTs showed improved blood pressure control compared to usual care?

Output: Three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many SRs of RCTs showed improved blood pressure control compared to usual care?. ### Response: Three.


Instruction: What was the adjusted MD in SBP?

Output: 2.7 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the adjusted MD in SBP?. ### Response: 2.7 mm Hg.


Instruction: What is the SBP of 2.7 mm Hg?

Output: adjusted MD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the SBP of 2.7 mm Hg?. ### Response: adjusted MD.


Instruction: What was not associated with lower blood pressure when paired with co-interventions?

Output: self-monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not associated with lower blood pressure when paired with co-interventions?. ### Response: self-monitoring.


Instruction: What was associated with a lower blood pressure?

Output: blood pressure self-monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with a lower blood pressure?. ### Response: blood pressure self-monitoring.


Instruction: What was the MD in SBP - 6.1 mm Hg?

Output: lower blood pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the MD in SBP - 6.1 mm Hg?. ### Response: lower blood pressure.


Instruction: How many additional RCTs had results consistent with the SRs?

Output: Three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many additional RCTs had results consistent with the SRs?. ### Response: Three.


Instruction: What is accompanied by a co -intervention involving medi cation titration in response to self-monitoring data?

Output: self- monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is accompanied by a co -intervention involving medi cation titration in response to self-monitoring data?. ### Response: self- monitoring.


Instruction: Studies in which medication adherence was examined revealed no difference in what?

Output: medication adherence between self -monitoring of blood pressure and usual care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Studies in which medication adherence was examined revealed no difference in what?. ### Response: medication adherence between self -monitoring of blood pressure and usual care.


Instruction: What did the Work Group members ask about a 2 -4 mm Hg reduction in blood pressure?

Output: whether a 2 -4 mm Hg reduction in blood pressure was clinically significant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Work Group members ask about a 2 -4 mm Hg reduction in blood pressure?. ### Response: whether a 2 -4 mm Hg reduction in blood pressure was clinically significant.


Instruction: How much blood pressure reduction was clinically significant?

Output: 2 -4 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much blood pressure reduction was clinically significant?. ### Response: 2 -4 mm Hg.


Instruction: Who expressed a desire for additional education on the use of home blood pressure management?

Output: patient focus gro up participants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who expressed a desire for additional education on the use of home blood pressure management?. ### Response: patient focus gro up participants.


Instruction: What might some patients not want the extra burden of monitoring their own blood pressure at home?

Output: variability in provider and patient preferences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What might some patients not want the extra burden of monitoring their own blood pressure at home?. ### Response: variability in provider and patient preferences.


Instruction: What is the added cost of a home blood pressure monitor if not provided by the institution?

Output: patients in whom HBPM is not feasible

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the added cost of a home blood pressure monitor if not provided by the institution?. ### Response: patients in whom HBPM is not feasible.


Instruction: What are the studies that support the recommendation summarized in Online Data Supplement 38.COR LOE Recommendation1 B-NR1?

Output: ThrombosisReferenced studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the studies that support the recommendation summarized in Online Data Supplement 38.COR LOE Recommendation1 B-NR1?. ### Response: ThrombosisReferenced studies.


Instruction: In patients with suspected mechanical prosthetic valve thrombosis, urgent evaluation with TTE, TEE, fluoroscopy, and/or multidetector CT imaging is indicated?

Output: to assess valve function, leaflet motion, and the presence and extent of thrombus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with suspected mechanical prosthetic valve thrombosis, urgent evaluation with TTE, TEE, fluoroscopy, and/or multidetector CT imaging is indicated?. ### Response: to assess valve function, leaflet motion, and the presence and extent of thrombus.


Instruction: What is a subacute to acute event resulting in rapid valve dysfunction?

Output: Mechanical valve thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a subacute to acute event resulting in rapid valve dysfunction?. ### Response: Mechanical valve thrombosis.


Instruction: What can be associated with inadequate VKA anticoagulation?

Output: Mechanical valve thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be associated with inadequate VKA anticoagulation?. ### Response: Mechanical valve thrombosis.


Instruction: What can be associated with recurrent valve thrombosis in the chronic setting?

Output: pannus ingrowth

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be associated with recurrent valve thrombosis in the chronic setting?. ### Response: pannus ingrowth.


Instruction: What can present with rapid onset of symp-toms or acute pulmonary edema?

Output: Mechanical valve thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can present with rapid onset of symp-toms or acute pulmonary edema?. ### Response: Mechanical valve thrombosis.


Instruction: What is the annual rate of prosthetic valve thrombosis with mechanical valves?

Output: 0.1% to 5.7%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the annual rate of prosthetic valve thrombosis with mechanical valves?. ### Response: 0.1% to 5.7%..


Instruction: What is seen for some specific valve types within the first 3 months after valve implanta-tion?

Output: Higher rates of mechanical valve thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is seen for some specific valve types within the first 3 months after valve implanta-tion?. ### Response: Higher rates of mechanical valve thrombosis.


Instruction: How long after valve implantation are mechanical valves implanted in the mitral or tricuspid position compared with the aortic position?

Output: 3 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after valve implantation are mechanical valves implanted in the mitral or tricuspid position compared with the aortic position?. ### Response: 3 months.


Instruction: What is diag-nosed by an abnormally elevated velocity or gra-dient across the prosthesis?

Output: Mechanical prosthetic valve thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is diag-nosed by an abnormally elevated velocity or gra-dient across the prosthesis?. ### Response: Mechanical prosthetic valve thrombosis.


Instruction: What is the most common cause of prosthetic valve obstruction?

Output: trans-valvular gradient increase >50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common cause of prosthetic valve obstruction?. ### Response: trans-valvular gradient increase >50%.


Instruction: What is a mean trans-valvular gradient increase >50%?

Output: Prosthetic valve obstruction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a mean trans-valvular gradient increase >50%?. ### Response: Prosthetic valve obstruction.


Instruction: How many mm Hg increase across an aortic prosthesis?

Output: >10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mm Hg increase across an aortic prosthesis?. ### Response: >10.


Instruction: What should be visualized with CT or TEE for a mitral prosthesis?

Output: Leaflet motion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be visualized with CT or TEE for a mitral prosthesis?. ### Response: Leaflet motion.


Instruction: What can imaging and Doppler data provide?

Output: information on valve function, estimated pulmonary pressures, and LV size and systolic function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can imaging and Doppler data provide?. ### Response: information on valve function, estimated pulmonary pressures, and LV size and systolic function.


Instruction: What is CT for?

Output: to assess valve function, leaflet motion, and the presence and extent of thrombus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CT for?. ### Response: to assess valve function, leaflet motion, and the presence and extent of thrombus.


Instruction: What is fluoroscopy for for an aor -tic prosthesis?

Output: Leaflet motion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is fluoroscopy for for an aor -tic prosthesis?. ### Response: Leaflet motion.


Instruction: How should thrombus be evaluated?

Output: by either TEE or CT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How should thrombus be evaluated?. ### Response: by either TEE or CT.


Instruction: When will the ahajournals.org be released?

Output: April 27, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When will the ahajournals.org be released?. ### Response: April 27, 2023.


Instruction: What type of exercise is supervised in a cardiac rehabilitation center?

Output: cardiovascular diseases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of exercise is supervised in a cardiac rehabilitation center?. ### Response: cardiovascular diseases.


Instruction: What is the focus of rehabilitation after cardiovascular diseases?

Output: developing countries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the focus of rehabilitation after cardiovascular diseases?. ### Response: developing countries.


Instruction: Where can you find the full text of Stable Ischemic Heart Disease?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find the full text of Stable Ischemic Heart Disease?. ### Response: http://ahajournals.org.


Instruction: What is the focus of the Focused Update on Atrial Fibrillation?

Output: against the risk of anticoagulant-related bleeding for the individual patient

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the focus of the Focused Update on Atrial Fibrillation?. ### Response: against the risk of anticoagulant-related bleeding for the individual patient.


Instruction: What is a risk of anticoagulant-related bleeding for the individual patient?

Output: against

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk of anticoagulant-related bleeding for the individual patient?. ### Response: against.


Instruction: AF Catheter Ablation to Maintain Sinus Rhythm6.3.4.

Output: Catheter Ablation in HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: AF Catheter Ablation to Maintain Sinus Rhythm6.3.4.. ### Response: Catheter Ablation in HF.


Instruction: Where are references to studies that support the new recommendation summarized?

Output: Online Data Supplement 7.COR LOE RecommendationIIb B-R1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are references to studies that support the new recommendation summarized?. ### Response: Online Data Supplement 7.COR LOE RecommendationIIb B-R1.


Instruction: What may be reasonable in selected patients?

Output: AF catheter ablation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be reasonable in selected patients?. ### Response: AF catheter ablation.


Instruction: What does HFrEF stand for?

Output: reduced left ventricular (LV) ejection fraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does HFrEF stand for?. ### Response: reduced left ventricular (LV) ejection fraction.


Instruction: What has been published for AF catheter ablation compared with medical therapy in patients with HF?

Output: New evidence, including data on improved mortality rate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been published for AF catheter ablation compared with medical therapy in patients with HF?. ### Response: New evidence, including data on improved mortality rate.


Instruction: What is CASTLE-AF?

Output: Catheter Ablation vs. Standard Conventional Treatment in Patients With LV Dysfunction and AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CASTLE-AF?. ### Response: Catheter Ablation vs. Standard Conventional Treatment in Patients With LV Dysfunction and AF.


Instruction: What type of device was implanted in patients with HFrEF with paroxysmal or persistent AF and could not take antiarrhyth-mic drugs?

Output: cardioverter-defibrillator or cardiac resynchronization therapy defibrillator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of device was implanted in patients with HFrEF with paroxysmal or persistent AF and could not take antiarrhyth-mic drugs?. ### Response: cardioverter-defibrillator or cardiac resynchronization therapy defibrillator.


Instruction: Who was randomized to receive AF catheter ablation versus medical therapy?

Output: selected patients with HFrEF with paroxysmal or persistent AF and an implanted cardioverter-defibrillator or cardiac resynchronization therapy defibrillator device who did not respond to or could not take antiarrhyth-mic drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was randomized to receive AF catheter ablation versus medical therapy?. ### Response: selected patients with HFrEF with paroxysmal or persistent AF and an implanted cardioverter-defibrillator or cardiac resynchronization therapy defibrillator device who did not respond to or could not take antiarrhyth-mic drugs.


Instruction: What was the difference between the two groups?

Output: reduced overall mortality rate, reduced rate of hospitaliza-tion for worsening HF, and improved LV ejection fraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the difference between the two groups?. ### Response: reduced overall mortality rate, reduced rate of hospitaliza-tion for worsening HF, and improved LV ejection fraction.


Instruction: Who had a significantly reduced overall mortality rate?

Output: Patients in the AF catheter ablation group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who had a significantly reduced overall mortality rate?. ### Response: Patients in the AF catheter ablation group.


Instruction: What was the overall mortality rate of the AF catheter ablation group compared to the medical therapy group?

Output: reduced

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the overall mortality rate of the AF catheter ablation group compared to the medical therapy group?. ### Response: reduced.


Instruction: What is the overall rate of hospitaliza-tion for worsening HF?

Output: reduced

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the overall rate of hospitaliza-tion for worsening HF?. ### Response: reduced.


Instruction: According to device interrogation, more patients in which group were in sinus rhythm?

Output: AF catheter ablation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: According to device interrogation, more patients in which group were in sinus rhythm?. ### Response: AF catheter ablation.


Instruction: What was superior to amiodarone for maintaining sinus rhythm?

Output: AF catheter ablation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was superior to amiodarone for maintaining sinus rhythm?. ### Response: AF catheter ablation.


Instruction: What was the lower rate of unplanned hospitalization and death?

Output: S6.3.4-2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the lower rate of unplanned hospitalization and death?. ### Response: S6.3.4-2.


Instruction: What is the lower rate of unplanned hospitalization and death?

Output: S6.3.4-2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the lower rate of unplanned hospitalization and death?. ### Response: S6.3.4-2.


Instruction: What are the limitations of both studies?

Output: relatively small and highly selected patient populations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the limitations of both studies?. ### Response: relatively small and highly selected patient populations.


Instruction: Are larger studies needed to validate these findings?

Output: second-ary endpoint analyses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Are larger studies needed to validate these findings?. ### Response: second-ary endpoint analyses.


Instruction: Have other studies shown the superiority of AF ablation over antiarrhythmic drugs?

Output: small studies conducted in patients with AF and HFrEF have shown the superiority of AF ablation over antiarrhythmic drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Have other studies shown the superiority of AF ablation over antiarrhythmic drugs?. ### Response: small studies conducted in patients with AF and HFrEF have shown the superiority of AF ablation over antiarrhythmic drugs.


Instruction: What is the superiority of AF ablation over antiarrhythmic drugs in the mainte-nance of sinus rhythm and in outcomes such as improved LV ejection fraction, performance in a 6-minute walk test, and quality of life?

Output: Other small studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the superiority of AF ablation over antiarrhythmic drugs in the mainte-nance of sinus rhythm and in outcomes such as improved LV ejection fraction, performance in a 6-minute walk test, and quality of life?. ### Response: Other small studies.


Instruction: The recent CABANA trial (n=2 204 patients) showed what?

Output: AF ablation was not superior to drug therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The recent CABANA trial (n=2 204 patients) showed what?. ### Response: AF ablation was not superior to drug therapy.


Instruction: How many patients were in the Anti-arrhythmic Drug Therapy for Atrial Fi-brillation) trial?

Output: 204

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were in the Anti-arrhythmic Drug Therapy for Atrial Fi-brillation) trial?. ### Response: 204.


Instruction: How many people were randomized to either catheter ablation or drug therapy?

Output: 204

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were randomized to either catheter ablation or drug therapy?. ### Response: 204.


Instruction: What chapter addresses the management of BP in adult CKDpatients without diabetes mellitus?

Output: Chapter 3: Blood pressure management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What chapter addresses the management of BP in adult CKDpatients without diabetes mellitus?. ### Response: Chapter 3: Blood pressure management.


Instruction: What is the definition of elderly?

Output: persons 465 years ofage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the definition of elderly?. ### Response: persons 465 years ofage.


Instruction: What are the two primary adverse outcomes of high BP?

Output: progression of kidney disease anddevelopment of CVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the two primary adverse outcomes of high BP?. ### Response: progression of kidney disease anddevelopment of CVD.


Instruction: What is sufficient to provide recommendations on BP targets?

Output: The data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is sufficient to provide recommendations on BP targets?. ### Response: The data.


Instruction: What did we divide the target populations on the basis of?

Output: urinealbumin level

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did we divide the target populations on the basis of?. ### Response: urinealbumin level.


Instruction: We did not find sufficient data to suggest any differences according to what stage?

Output: CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: We did not find sufficient data to suggest any differences according to what stage?. ### Response: CKD.


Instruction: What are the targets for all the various causes of CKD?

Output: BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the targets for all the various causes of CKD?. ### Response: BP.


Instruction: There is no evidence from RCTs to indicate that the treatment approachshould differ substantially for the patient with glomerulardisease and high urine albumin levels compared to thepatient with severerenovascular disease?

Output: Although there are strong observational data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is no evidence from RCTs to indicate that the treatment approachshould differ substantially for the patient with glomerulardisease and high urine albumin levels compared to thepatient with severerenovascular disease?. ### Response: Although there are strong observational data.


Instruction: What is the target range for severe renovascular disease?

Output: lowest to highest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the target range for severe renovascular disease?. ### Response: lowest to highest.


Instruction: Why would we have preferred to give a target range rather than a single target for highest acceptable BP?

Output: thereare insufﬁcient data based on RCTs to recommend a targetfor lowest BP level

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why would we have preferred to give a target range rather than a single target for highest acceptable BP?. ### Response: thereare insufﬁcient data based on RCTs to recommend a targetfor lowest BP level.


Instruction: There is insufficient data based on what?

Output: RCTs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is insufficient data based on what?. ### Response: RCTs.


Instruction: What do recommendations and suggestions in this chapter emphasize?

Output: an approach based onhighest acceptable BP and severity of albuminuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do recommendations and suggestions in this chapter emphasize?. ### Response: an approach based onhighest acceptable BP and severity of albuminuria.


Instruction: What should be implemented cautiously and with subsequent surveillance for adverse effects?

Output: interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be implemented cautiously and with subsequent surveillance for adverse effects?. ### Response: interventions.


Instruction: What might be necessary for BP control?

Output: BP agents other than thoserecommended or suggested below, such as diuretics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What might be necessary for BP control?. ### Response: BP agents other than thoserecommended or suggested below, such as diuretics.


Instruction: As CKD progresses, what becomes more of an issue?

Output: volume retention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: As CKD progresses, what becomes more of an issue?. ### Response: volume retention.


Instruction: How many RCTs addressing hard cardiovascular or kidney outcomes have randomized patients to a diuretic versus another agent?

Output: few

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs addressing hard cardiovascular or kidney outcomes have randomized patients to a diuretic versus another agent?. ### Response: few.


Instruction: What do we do not provide as a preferred second-lineagent?

Output: a guidelinestatement regarding diuretic use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do we do not provide as a preferred second-lineagent?. ### Response: a guidelinestatement regarding diuretic use.


Instruction: What is discussed in more detail below?

Output: The use of diuretics and other BP agents

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is discussed in more detail below?. ### Response: The use of diuretics and other BP agents.


Instruction: What is the office BP of non-diabetic adults with CKDND and urine albumin excretion o30 mg per 24 hours(or equivalent*)?

Output: 4140 mm Hg systolic or 490 mm Hg diastolic betreated with BP-lowering drugs to maintain a BP thatis consistently r140 mm Hg systolic and r90 mm Hgdiastolic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the office BP of non-diabetic adults with CKDND and urine albumin excretion o30 mg per 24 hours(or equivalent*)?. ### Response: 4140 mm Hg systolic or 490 mm Hg diastolic betreated with BP-lowering drugs to maintain a BP thatis consistently r140 mm Hg systolic and r90 mm Hgdiastolic.


Instruction: How many mm Hgdiastolic are there?

Output: r90

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mm Hgdiastolic are there?. ### Response: r90.


Instruction: What are the approximate equivalents for albumin excretion per 24 hours?

Output: 1B)*

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the approximate equivalents for albumin excretion per 24 hours?. ### Response: 1B)*.


Instruction: What is the purpose of guidelines?

Output: to make them shorter and enhance “user-friendliness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of guidelines?. ### Response: to make them shorter and enhance “user-friendliness.


Instruction: How are guidelines written and presented?

Output: in a modular “knowledge chunk” format

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are guidelines written and presented?. ### Response: in a modular “knowledge chunk” format.


Instruction: What type of references are provided for each modular knowledge chunk?

Output: Hyperlinked

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of references are provided for each modular knowledge chunk?. ### Response: Hyperlinked.


Instruction: What is provided for each modular knowledge chunk to facilitate quick access and review?

Output: Hyperlinked references

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is provided for each modular knowledge chunk to facilitate quick access and review?. ### Response: Hyperlinked references.


Instruction: Word limit targets and a web supplement are what?

Output: 2 recent modifications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Word limit targets and a web supplement are what?. ### Response: 2 recent modifications.


Instruction: What may be performed in accordance with the ACC/AHA methodology?

Output: value for a drug, device, or in-tervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be performed in accordance with the ACC/AHA methodology?. ### Response: value for a drug, device, or in-tervention.


Instruction: To ensure that guideline recommendations remain current, new data will be reviewed on an ongoing basis by the writing committee and staff?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: To ensure that guideline recommendations remain current, new data will be reviewed on an ongoing basis by the writing committee and staff?. ### Response: 3.


Instruction: What will be revised dynamically after publication and timely peer review of potentially practice-changing science?

Output: targeted sections or knowledge chunks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will be revised dynamically after publication and timely peer review of potentially practice-changing science?. ### Response: targeted sections or knowledge chunks.


Instruction: The previous designations of what will be phased out?

Output: “full revision” and “focused update”

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The previous designations of what will be phased out?. ### Response: “full revision” and “focused update”.


Instruction: What does the Joint Committee strive to ensure the guideline writing committee members have requisite content expertise and are representative of?

Output: the broader cardio-vascular community

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Joint Committee strive to ensure the guideline writing committee members have requisite content expertise and are representative of?. ### Response: the broader cardio-vascular community.


Instruction: What are experts selected across a spec-trum of backgrounds?

Output: different geographic regions, sexes, races, ethnicities, intellectual perspectives or biases, and clinical practice settings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are experts selected across a spec-trum of backgrounds?. ### Response: different geographic regions, sexes, races, ethnicities, intellectual perspectives or biases, and clinical practice settings.


Instruction: What are organizations and professional societies invited to participate as partners or collaborators?

Output: related interests and expertise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are organizations and professional societies invited to participate as partners or collaborators?. ### Response: related interests and expertise.


Instruction: Who are invited to participate as partners or collaborators?

Output: Organizations and professional societies with related interests and expertise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who are invited to participate as partners or collaborators?. ### Response: Organizations and professional societies with related interests and expertise.


Instruction: Who have rigorous policies and meth-ods to ensure that documents are developed without bias or improper influence?

Output: The ACC and AHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who have rigorous policies and meth-ods to ensure that documents are developed without bias or improper influence?. ### Response: The ACC and AHA.


Instruction: What is the complete policy on re-lationships with industry and other entities?

Output: RWI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the complete policy on re-lationships with industry and other entities?. ### Response: RWI.


Instruction: What can be found at https://www.acc.org/guidelines/about-guidelines-and-clinical-documents/relationships-with-industry-policy?

Output: re-lationships with industry and other entities (RWI)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be found at https://www.acc.org/guidelines/about-guidelines-and-clinical-documents/relationships-with-industry-policy?. ### Response: re-lationships with industry and other entities (RWI).


Instruction: What does Appendix 1 of the guideline list?

Output: writing committee members’ relevant RWI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Appendix 1 of the guideline list?. ### Response: writing committee members’ relevant RWI.


Instruction: What has been recom-ended by experts for patients with infections caused by susceptible organisms?

Output: suppressive therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been recom-ended by experts for patients with infections caused by susceptible organisms?. ### Response: suppressive therapy.


Instruction: What agent has been added to amphotericin B given by mouth for Candida endocarditis caused by strains of bacteria?

Output: 5-fluorocytosine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What agent has been added to amphotericin B given by mouth for Candida endocarditis caused by strains of bacteria?. ### Response: 5-fluorocytosine.


Instruction: What can be given by mouth for Candida endocarditis?

Output: amphotericin B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be given by mouth for Candida endocarditis?. ### Response: amphotericin B.


Instruction: Monitoring blood levels of 5-FC will minimize what?

Output: toxicity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Monitoring blood levels of 5-FC will minimize what?. ### Response: toxicity.


Instruction: What may act synergistically and potentiate fungal killing?

Output: gentamicin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may act synergistically and potentiate fungal killing?. ### Response: gentamicin.


Instruction: What can potentiate fungal killing?

Output: 2 drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can potentiate fungal killing?. ### Response: 2 drugs.


Instruction: What is an alternative for patients with moderate to severe renal impairment or those with unacceptable infusion-related toxicities?

Output: liposomal forms of amphotericin B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an alternative for patients with moderate to severe renal impairment or those with unacceptable infusion-related toxicities?. ### Response: liposomal forms of amphotericin B.


Instruction: What type of endocarditis can be successfully treated?

Output: fungal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of endocarditis can be successfully treated?. ### Response: fungal.


Instruction: What is required for most patients with fungal IE for surgery in con-junction with antifungal agents?

Output: Early consultation with infectious disease, cardiology, and cardiac surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is required for most patients with fungal IE for surgery in con-junction with antifungal agents?. ### Response: Early consultation with infectious disease, cardiology, and cardiac surgery.


Instruction: How many mg/kg per day is 5-FC divided into?

Output: 100–150

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mg/kg per day is 5-FC divided into?. ### Response: 100–150.


Instruction: What is the dose of 5-FC divided every 6 hours?

Output: 100–150 mg/kg per day

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the dose of 5-FC divided every 6 hours?. ### Response: 100–150 mg/kg per day.


Instruction: What is a class IIb; Level of Evidence C)?

Output: Monitoring of Antibiotic Blood Levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a class IIb; Level of Evidence C)?. ### Response: Monitoring of Antibiotic Blood Levels.


Instruction: What is a reasonable dose of gentamicin in children?

Output: 3 to 6 mg/kg per day

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a reasonable dose of gentamicin in children?. ### Response: 3 to 6 mg/kg per day.


Instruction: What is the target peak blood concentration?

Output: 3 to 4 μg/mL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the target peak blood concentration?. ### Response: 3 to 4 μg/mL.


Instruction: How is the dose adjusted for a trough?

Output: <1 μg/mL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the dose adjusted for a trough?. ### Response: <1 μg/mL.


Instruction: What is the daily dose divided into?

Output: 3 doses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the daily dose divided into?. ### Response: 3 doses.


Instruction: How many doses is needed per day for treatment of Gram-negative rod isolates?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many doses is needed per day for treatment of Gram-negative rod isolates?. ### Response: 3.


Instruction: What are the peak blood levels?

Output: 5 to 10 μg/mL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the peak blood levels?. ### Response: 5 to 10 μg/mL.


Instruction: What is the daily dose of vancomy-cin divided into?

Output: 3 doses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the daily dose of vancomy-cin divided into?. ### Response: 3 doses.


Instruction: How many doses are given every 8 hours?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many doses are given every 8 hours?. ### Response: 3.


Instruction: What is there insufficient clinical experience for treating pediatric IE with single daily dosing?

Output: there is insufficient clinical experience for treat-ment of pediatric IE with single daily dosing. For vancomy-cin, a starting dose for children is 40 to 60 mg/kg per day, and only trough concentrations are used for monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is there insufficient clinical experience for treating pediatric IE with single daily dosing?. ### Response: there is insufficient clinical experience for treat-ment of pediatric IE with single daily dosing. For vancomy-cin, a starting dose for children is 40 to 60 mg/kg per day, and only trough concentrations are used for monitoring.


Instruction: A starting dose for children is 40 to what?

Output: 60 mg/kg per day

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A starting dose for children is 40 to what?. ### Response: 60 mg/kg per day.


Instruction: How many mg/kg of vancomycin per day are used for monitoring?

Output: 40 to 60 mg/kg per day, and only trough concentrations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mg/kg of vancomycin per day are used for monitoring?. ### Response: 40 to 60 mg/kg per day, and only trough concentrations.


Instruction: What is the target trough blood level for methicillin/oxacillin/nafcillin-resistant staphylococci?

Output: 10 to 15 μg/mL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the target trough blood level for methicillin/oxacillin/nafcillin-resistant staphylococci?. ### Response: 10 to 15 μg/mL.


Instruction: A higher blood level of 15 to 20 g/mL may be required to treat what?

Output: methicillin/oxacillin/nafcillin-resistant staphylococci

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A higher blood level of 15 to 20 g/mL may be required to treat what?. ### Response: methicillin/oxacillin/nafcillin-resistant staphylococci.


Instruction: What is a vancomycin MIC of >1 g/mL?

Output: 15 to 20 μg/mL, may be required to treat methicillin/oxacillin/nafcillin-resistant staphylococci

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a vancomycin MIC of >1 g/mL?. ### Response: 15 to 20 μg/mL, may be required to treat methicillin/oxacillin/nafcillin-resistant staphylococci.


Instruction: Children with renal failure require dosage adjustments?

Output: guidance from phar -macists, infectious diseases, or renal diseases consultants is recommended

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Children with renal failure require dosage adjustments?. ### Response: guidance from phar -macists, infectious diseases, or renal diseases consultants is recommended.


Instruction: What is recommended when gentamicin is used for synergy?

Output: 3 to 6 mg/kg per day

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended when gentamicin is used for synergy?. ### Response: 3 to 6 mg/kg per day.


Instruction: What is a reason-able dose of 3 to 6 mg/kg per day divided as an every 8-hour regimen in children?

Output: gentamicin is used for synergy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a reason-able dose of 3 to 6 mg/kg per day divided as an every 8-hour regimen in children?. ### Response: gentamicin is used for synergy.


Instruction: What is the trough of 1 g/mL (Class IIa; Level of Evidence B)?

Output: <1 to 1.5 μg/mL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the trough of 1 g/mL (Class IIa; Level of Evidence B)?. ### Response: <1 to 1.5 μg/mL.


Instruction: Which aspirin dose and preparation is best for the long-term prevention of cardiovascular disease and cancer?

Output: Lotrionte M, Biasucci LM, Peruzzi M, et al. Which aspirin dose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which aspirin dose and preparation is best for the long-term prevention of cardiovascular disease and cancer?. ### Response: Lotrionte M, Biasucci LM, Peruzzi M, et al. Which aspirin dose.


Instruction: Preventive Services Task Force. 2016;164:826–35.

Output: S4.6-3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Preventive Services Task Force. 2016;164:826–35.. ### Response: S4.6-3.