Instruction: What is longer in strokepatients?

Output: lengths of stay

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is longer in strokepatients?. ### Response: lengths of stay.


Instruction: Off-pump CABG was introduced in large part to reduce what?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Off-pump CABG was introduced in large part to reduce what?. ### Response: stroke.


Instruction: What has shown no difference in strokerates?

Output: several RCTs comparing on-pump andoff-pump CABG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has shown no difference in strokerates?. ### Response: several RCTs comparing on-pump andoff-pump CABG.


Instruction: What is the use of Epiaortic Ultrasound Imaging to Reduce?

Output: Stroke Rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the use of Epiaortic Ultrasound Imaging to Reduce?. ### Response: Stroke Rates.


Instruction: What is an important step in reducing the risk of stroke afterCABG?

Output: Identification of an atherosclerotic aorta

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an important step in reducing the risk of stroke afterCABG?. ### Response: Identification of an atherosclerotic aorta.


Instruction: What is superior to direct palpation and TEE?

Output: Intraoperative assessment of the ascending aortafor detection of plaque by epiaortic ultrasound imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is superior to direct palpation and TEE?. ### Response: Intraoperative assessment of the ascending aortafor detection of plaque by epiaortic ultrasound imaging.


Instruction: How is intraoperative assessment of the ascending aorta assessed?

Output: epiaortic ultrasound imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is intraoperative assessment of the ascending aorta assessed?. ### Response: epiaortic ultrasound imaging.


Instruction: What are some predictors ofascending aortic atherosclerosis?

Output: increasing age,hypertension, extracardiac atherosclerosis (peripheral ar-tery and cerebrovascular disease), and elevated serumcreatinine concentrations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some predictors ofascending aortic atherosclerosis?. ### Response: increasing age,hypertension, extracardiac atherosclerosis (peripheral ar-tery and cerebrovascular disease), and elevated serumcreatinine concentrations.


Instruction: What was the stroke rate reported by several observational studies?

Output: 0 to 1.4%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the stroke rate reported by several observational studies?. ### Response: 0 to 1.4%.


Instruction: What was guided by the results of epiaortic scanning?

Output: surgical decision making

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was guided by the results of epiaortic scanning?. ### Response: surgical decision making.


Instruction: When were separate guidelines for the use ofintraoperative epiachortic ultrasound in cardiacsurgery published?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When were separate guidelines for the use ofintraoperative epiachortic ultrasound in cardiacsurgery published?. ### Response: 2008.


Instruction: What is a multidisciplinary team approach for patients with clinically significant carotid artery disease?

Output: consisting of acardiologist, cardiac surgeon, vascular surgeon, andneurologist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a multidisciplinary team approach for patients with clinically significant carotid artery disease?. ### Response: consisting of acardiologist, cardiac surgeon, vascular surgeon, andneurologist.


Instruction: What is STS.1475.2.1.1.2?

Output: Separate guidelines for the use ofintraoperative epiaortic ultrasound imaging in cardiacsurgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is STS.1475.2.1.1.2?. ### Response: Separate guidelines for the use ofintraoperative epiaortic ultrasound imaging in cardiacsurgery.


Instruction: What type of scan is reasonable for patients with clinically significant carotid artery disease?

Output: Carotid artery duplex scanning

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of scan is reasonable for patients with clinically significant carotid artery disease?. ### Response: Carotid artery duplex scanning.


Instruction: What is the level of evidence for CABG?

Output: 858,859

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the level of evidence for CABG?. ### Response: 858,859.


Instruction: What is the acronym for cerebrovascular disease?

Output: extracardiac atherosclerosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for cerebrovascular disease?. ### Response: extracardiac atherosclerosis.


Instruction: What is TIA?

Output: transient ischemic attack

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is TIA?. ### Response: transient ischemic attack.


Instruction: Where can you find the 2011 ACCF/AHA CABG Guideline?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find the 2011 ACCF/AHA CABG Guideline?. ### Response: http://ahajournals.org.


Instruction: What is the MIC of patients with enterococci?

Output: >0.5 μg of penicillin per milliliter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the MIC of patients with enterococci?. ### Response: >0.5 μg of penicillin per milliliter.


Instruction: What should be used for children who are unable to take antibiotics?

Output: vancomycin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be used for children who are unable to take antibiotics?. ### Response: vancomycin.


Instruction: When was the Circulation of 1502?

Output: October 13, 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circulation of 1502?. ### Response: October 13, 2015.


Instruction: What is an effective substitute for -lactam antibiotic drugs for children?

Output: vancomycin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an effective substitute for -lactam antibiotic drugs for children?. ### Response: vancomycin.


Instruction: What is the current practice of adding gentamicin for a 4-week course?

Output: vancomycin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the current practice of adding gentamicin for a 4-week course?. ### Response: vancomycin.


Instruction: Why do you need to obtain blood concentrations of vancomycin and gentamicin weekly?

Output: because of the possibility of nephrotoxicity with multiple nephrotoxic antibiotic drugs may be con-sidered

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why do you need to obtain blood concentrations of vancomycin and gentamicin weekly?. ### Response: because of the possibility of nephrotoxicity with multiple nephrotoxic antibiotic drugs may be con-sidered.


Instruction: What may be con-sidered as weekly renal function tests?

Output: blood concentrations of vancomycin and gentamicin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be con-sidered as weekly renal function tests?. ### Response: blood concentrations of vancomycin and gentamicin.


Instruction: What is the class IIb; Level of Evidence C?

Output: renal function tests, weekly because of the possibility of nephrotoxicity with multiple nephrotoxic antibiotic drugs may be con-sidered

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the class IIb; Level of Evidence C?. ### Response: renal function tests, weekly because of the possibility of nephrotoxicity with multiple nephrotoxic antibiotic drugs may be con-sidered.


Instruction: Endocarditis is caused by what?

Output: penicillin-susceptible streptococcal strain

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Endocarditis is caused by what?. ### Response: penicillin-susceptible streptococcal strain.


Instruction: What type of material is used for prosthetic material?

Output: endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of material is used for prosthetic material?. ### Response: endocarditis.


Instruction: How long is the antibiotic therapy?

Output: 6 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the antibiotic therapy?. ### Response: 6 weeks.


Instruction: What is the MIC of a penicillin-susceptible streptococcal strain?

Output: >0.1 μg of penicillin per milliliter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the MIC of a penicillin-susceptible streptococcal strain?. ### Response: >0.1 μg of penicillin per milliliter.


Instruction: How long does it take to combine penicillin, ampicillin, or ceftriaxone with gentamicin?

Output: 6 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take to combine penicillin, ampicillin, or ceftriaxone with gentamicin?. ### Response: 6 weeks.


Instruction: What is used for patients unable to tolerate -lactam therapy?

Output: vancomycin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used for patients unable to tolerate -lactam therapy?. ### Response: vancomycin.


Instruction: How long is it necessary to combine vancomycin and gentamizin for a patient with a MIC >0.1 g of penicillin per milliliter?

Output: 4-week

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is it necessary to combine vancomycin and gentamizin for a patient with a MIC >0.1 g of penicillin per milliliter?. ### Response: 4-week.


Instruction: How long is vancomycin combined with gentamicin for?

Output: 4-week

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is vancomycin combined with gentamicin for?. ### Response: 4-week.


Instruction: What is the first 2 weeks of therapy for -lactam-intolerant patients with Abiotrophia infections?

Output: vancomycin for 6 weeks is combined with gentamicin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the first 2 weeks of therapy for -lactam-intolerant patients with Abiotrophia infections?. ### Response: vancomycin for 6 weeks is combined with gentamicin.


Instruction: In cases where endocarditis occurs in the setting of prosthetic material, what is recommended?

Output: therapy is continued for 6 weeks with penicillin, ampi-cillin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In cases where endocarditis occurs in the setting of prosthetic material, what is recommended?. ### Response: therapy is continued for 6 weeks with penicillin, ampi-cillin.


Instruction: What is used for the first 2 weeks of therapy for infections caused by a penicil-lin-susceptible streptococcal strain?

Output: penicillin, ampicillin, or ceftriaxone combined with gentamicin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used for the first 2 weeks of therapy for infections caused by a penicil-lin-susceptible streptococcal strain?. ### Response: penicillin, ampicillin, or ceftriaxone combined with gentamicin.


Instruction: What is the MIC of a strain with >0.1 g of penicillin per week?

Output: milliliter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the MIC of a strain with >0.1 g of penicillin per week?. ### Response: milliliter.


Instruction: What type of endocarditis is relatively rare?

Output: Enterococcal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of endocarditis is relatively rare?. ### Response: Enterococcal.


Instruction: How long is it recommended to combine penicillin, ampicillin, or ceftriaxone with gentamicin?

Output: 6 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is it recommended to combine penicillin, ampicillin, or ceftriaxone with gentamicin?. ### Response: 6 weeks.


Instruction: What is relatively rare in children?

Output: Enterococcal IE on Native Cardiac Valves or Prosthetic MaterialEnterococcal endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is relatively rare in children?. ### Response: Enterococcal IE on Native Cardiac Valves or Prosthetic MaterialEnterococcal endocarditis.


Instruction: What is difficult to treat because of the relative resistance of enterococci to penicillin and ampicillin?

Output: Enterococcal IE on Native Cardiac Valves or Prosthetic MaterialEnterococcal endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is difficult to treat because of the relative resistance of enterococci to penicillin and ampicillin?. ### Response: Enterococcal IE on Native Cardiac Valves or Prosthetic MaterialEnterococcal endocarditis.


Instruction: How is the treatment regimen for native valve IE caused?

Output: susceptible strains

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the treatment regimen for native valve IE caused?. ### Response: susceptible strains.


Instruction: What should be the treatment regimen for native valve IE caused by susceptible strains?

Output: a combination therapy of penicillin G or ampicillin together with gentamicin for 4 to 6 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be the treatment regimen for native valve IE caused by susceptible strains?. ### Response: a combination therapy of penicillin G or ampicillin together with gentamicin for 4 to 6 weeks.


Instruction: How long should the combination therapy of penicillin G or ampicillin together with gentamicin be?

Output: 4 to 6 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long should the combination therapy of penicillin G or ampicillin together with gentamicin be?. ### Response: 4 to 6 weeks.


Instruction: What should the longer duration of therapy be in cases involving prosthetic material?

Output: 6 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should the longer duration of therapy be in cases involving prosthetic material?. ### Response: 6 weeks.


Instruction: What do experts recommend for patients with enterococci infections who are unable to tolerate  -lactam therapy?

Output: vancomycin combined with gentamicin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do experts recommend for patients with enterococci infections who are unable to tolerate  -lactam therapy?. ### Response: vancomycin combined with gentamicin.


Instruction: What does vancomycin combine with gentamicin for?

Output: a 4-week course

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does vancomycin combine with gentamicin for?. ### Response: a 4-week course.


Instruction: What is the name of the reference list for Chronic Heart Failure?

Output: NICE 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the reference list for Chronic Heart Failure?. ### Response: NICE 2018.


Instruction: What are the rights reserved?

Output: All rights reserved

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the rights reserved?. ### Response: All rights reserved.


Instruction: How is the cost-effectiveness analyse measured?

Output: serial measurement of circulating natriuretic peptide concentration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the cost-effectiveness analyse measured?. ### Response: serial measurement of circulating natriuretic peptide concentration.


Instruction: What is of serial measurement of circulating natriuretic peptide concentration in chronic heart failure?

Output: Cost -effectiveness analys

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is of serial measurement of circulating natriuretic peptide concentration in chronic heart failure?. ### Response: Cost -effectiveness analys.


Instruction: What year did Heart. 2013; 99(4):267 -271 192?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Heart. 2013; 99(4):267 -271 192?. ### Response: 2013.


Instruction: What is ips with bisoprolol benefit in chronic heart failure in CIBIS II Trial?

Output: Heart rate and cardiac rhythm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ips with bisoprolol benefit in chronic heart failure in CIBIS II Trial?. ### Response: Heart rate and cardiac rhythm.


Instruction: What is multidisciplinary care of heart failure when combined with op timal medical care?

Output: cost -beneficial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is multidisciplinary care of heart failure when combined with op timal medical care?. ### Response: cost -beneficial.


Instruction: What is eplerenone used for in patients with systolic heart failure and mild symptoms?

Output: Cost -effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is eplerenone used for in patients with systolic heart failure and mild symptoms?. ### Response: Cost -effectiveness.


Instruction: When was the European Journal of Heart Failure published?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the European Journal of Heart Failure published?. ### Response: 2003.


Instruction: What is the name of the journal that studies the relationship between heart failure and mild symptoms?

Output: Heart

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies the relationship between heart failure and mild symptoms?. ### Response: Heart.


Instruction: What are the names of the authors of Heart. 2014; 100(21):168 1-7 195?

Output: Lee DS, Austin PC, Rouleau JL, Liu PP, Naimark D, Tu JV

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the authors of Heart. 2014; 100(21):168 1-7 195?. ### Response: Lee DS, Austin PC, Rouleau JL, Liu PP, Naimark D, Tu JV.


Instruction: How is mortality predicted among patients hospitalized for heart failure?

Output: derivation and validation of a clinical model

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is mortality predicted among patients hospitalized for heart failure?. ### Response: derivation and validation of a clinical model.


Instruction: When was the JAMA 290(19):2581 -7 196?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the JAMA 290(19):2581 -7 196?. ### Response: 2003.


Instruction: What type of defibrillators are implanted in patients at the end of life?

Output: cardioverter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of defibrillators are implanted in patients at the end of life?. ### Response: cardioverter.


Instruction: What is the name of the journal that studies the decision-making of patients with implantable cardioverter-defibrilliantators?

Output: American Journal of Hospice & Palliative Medicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies the decision-making of patients with implantable cardioverter-defibrilliantators?. ### Response: American Journal of Hospice & Palliative Medicine.


Instruction: Whose experiences have helped families make decisions about implantable cardiac arrest devices?

Output: Family members

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Whose experiences have helped families make decisions about implantable cardiac arrest devices?. ### Response: Family members.


Instruction: When was the American Journal of Hospice & Paliative Medicine published?

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the American Journal of Hospice & Paliative Medicine published?. ### Response: 2017.


Instruction: How does the Val -HeFT study compare with baseline and early worsening of renal function?

Output: Interaction between baseline and early worsening of renal function and efficacy of renin -angiotensin -aldosterone system blockade

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does the Val -HeFT study compare with baseline and early worsening of renal function?. ### Response: Interaction between baseline and early worsening of renal function and efficacy of renin -angiotensin -aldosterone system blockade.


Instruction: What is the effect of renin-angiotensin -aldosterone system blockade in heart failure patients?

Output: worsening of renal function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of renin-angiotensin -aldosterone system blockade in heart failure patients?. ### Response: worsening of renal function.


Instruction: What did the Val -HeFT study provide insights from?

Output: Interaction between baseline and early worsening of renal function and efficacy of renin -angiotensin -aldosterone system blockade in patients with heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Val -HeFT study provide insights from?. ### Response: Interaction between baseline and early worsening of renal function and efficacy of renin -angiotensin -aldosterone system blockade in patients with heart failure.


Instruction: What did Levy WC, Mozaffarian D, Linker DT, Sutradhar SC, Anker SD, Cropp AB et al. predict in heart failure?

Output: survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Levy WC, Mozaffarian D, Linker DT, Sutradhar SC, Anker SD, Cropp AB et al. predict in heart failure?. ### Response: survival.


Instruction: What is spironolactone used for in the treatment of preserved cardiac function heart failure with an aldosterone antagonist trial?

Output: longitudinal changes in health -related quality of life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is spironolactone used for in the treatment of preserved cardiac function heart failure with an aldosterone antagonist trial?. ### Response: longitudinal changes in health -related quality of life.


Instruction: What is the effect of oral iron repletion on exercise capacity in patients with heart failure with reduced ejection fraction and iron?

Output: The IRONOUT HF randomized clinical trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of oral iron repletion on exercise capacity in patients with heart failure with reduced ejection fraction and iron?. ### Response: The IRONOUT HF randomized clinical trial.


Instruction: What does aldosterone antagonist do?

Output: Impact of spironolactone on longitudinal changes in health -related quality of life in the treatment of preserved cardiac function heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does aldosterone antagonist do?. ### Response: Impact of spironolactone on longitudinal changes in health -related quality of life in the treatment of preserved cardiac function heart failure.


Instruction: What is the name of the randomized clinical trial for patients with heart failure with reduced ejection fraction and iron deficiency?

Output: IRONOUT HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized clinical trial for patients with heart failure with reduced ejection fraction and iron deficiency?. ### Response: IRONOUT HF.


Instruction: When was the JAMA 317(19):1958 -1966 201 published?

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the JAMA 317(19):1958 -1966 201 published?. ### Response: 2017.


Instruction: What is ferric carboxymaltose called in South Korea?

Output: Ferinject

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ferric carboxymaltose called in South Korea?. ### Response: Ferinject.


Instruction: What type of anemia are patients with heart failure in South Korea?

Output: iron -deficiency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of anemia are patients with heart failure in South Korea?. ### Response: iron -deficiency.


Instruction: What year did Cost Effectiveness & Resource Allocation issue 12:19202?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Cost Effectiveness & Resource Allocation issue 12:19202?. ### Response: 2014.


Instruction: Fondaparinux can be administered subcutaneously once daily in fi xed doses without coagulation monitoring.

Output: almost complete bioavailability after subcutaneous injection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Fondaparinux can be administered subcutaneously once daily in fi xed doses without coagulation monitoring.. ### Response: almost complete bioavailability after subcutaneous injection.


Instruction: Fondaparainux is nearly completely dependent on what?

Output: renal clearance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Fondaparainux is nearly completely dependent on what?. ### Response: renal clearance.


Instruction: What is Fondaparinux completely dependent on?

Output: renal clearance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Fondaparinux completely dependent on?. ### Response: renal clearance.


Instruction: What is CrCl, 30 mL/min?

Output: renal insuf-ﬁ ciency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CrCl, 30 mL/min?. ### Response: renal insuf-ﬁ ciency.


Instruction: What is the daily dose of thrombopro-phylaxis used for?

Output: 2.5 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the daily dose of thrombopro-phylaxis used for?. ### Response: 2.5 mg.


Instruction: What is given at 7.5 mg for patients with a body weight of 50 to 100 kg?

Output: Fondaparinux

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is given at 7.5 mg for patients with a body weight of 50 to 100 kg?. ### Response: Fondaparinux.


Instruction: How is the dose decreased for patients weighing between 50 and 100 kilograms?

Output: increased to 10 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the dose decreased for patients weighing between 50 and 100 kilograms?. ### Response: increased to 10 mg.


Instruction: What is the dose of Fondaparinux decreased to for patients weighing 50 kg?

Output: 5 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the dose of Fondaparinux decreased to for patients weighing 50 kg?. ### Response: 5 mg.


Instruction: The dose is increased to 10 mg for those weighing 100 kg.

Output: Fondaparinux

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The dose is increased to 10 mg for those weighing 100 kg.. ### Response: Fondaparinux.


Instruction: What has not been monitored in clinical studies?

Output: Fondaparinux

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has not been monitored in clinical studies?. ### Response: Fondaparinux.


Instruction: Routine coagulation monitoring is not recommended in patients with what?

Output: Fondaparinux

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Routine coagulation monitoring is not recommended in patients with what?. ### Response: Fondaparinux.


Instruction: What is not recommended in patients with renal insufficiency?

Output: routine coagulation monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended in patients with renal insufficiency?. ### Response: routine coagulation monitoring.


Instruction: How much should fondaparinux be reduced by?

Output: 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much should fondaparinux be reduced by?. ### Response: 50%.


Instruction: What should low-dose heparin be used in place of?

Output: fondaparinux

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should low-dose heparin be used in place of?. ### Response: fondaparinux.


Instruction: What is not recom-mended on a routine basis?

Output: coagulation monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recom-mended on a routine basis?. ### Response: coagulation monitoring.


Instruction: What can be measured using fondaparinux-specifi c anti-Xa assays?

Output: anticoagulant activity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be measured using fondaparinux-specifi c anti-Xa assays?. ### Response: anticoagulant activity.


Instruction: The therapeutic anti-xa range has not been established for what drug?

Output: fondaparinux

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The therapeutic anti-xa range has not been established for what drug?. ### Response: fondaparinux.


Instruction: What is the daily dose of fondaparinux?

Output: 2.5 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the daily dose of fondaparinux?. ### Response: 2.5 mg.


Instruction: At what dose is the peak steady-state plasma con-centration?

Output: 2.5 mg daily dose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: At what dose is the peak steady-state plasma con-centration?. ### Response: 2.5 mg daily dose.


Instruction: How long after a dose is a peak steady state plasma concentration reached?

Output: 3 h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after a dose is a peak steady state plasma concentration reached?. ### Response: 3 h.


Instruction: What is an example of a therapeutic dose?

Output: 7.5 mg daily for an individual of average body weight

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a therapeutic dose?. ### Response: 7.5 mg daily for an individual of average body weight.


Instruction: What is the antidote for heparin?

Output: protamine sulfate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the antidote for heparin?. ### Response: protamine sulfate.


Instruction: Fondaparinux does not bind to what?

Output: protamine sulfate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Fondaparinux does not bind to what?. ### Response: protamine sulfate.


Instruction: What can cause uncontrollable bleeding?

Output: fondaparinux

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can cause uncontrollable bleeding?. ### Response: fondaparinux.


Instruction: What may be effective if uncontrollable bleeding occurs with fondaparinux?

Output: recombinant factor VIIa

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be effective if uncontrollable bleeding occurs with fondaparinux?. ### Response: recombinant factor VIIa.


Instruction: What is the low affi nity for PF4 and does not cross-react with HIT antibodies?

Output: Fondaparinux

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the low affi nity for PF4 and does not cross-react with HIT antibodies?. ### Response: Fondaparinux.


Instruction: HIT antibodies without thrombocytopenia have been reported in patients given prophylaxis with fondaparinux?

Output: HIT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: HIT antibodies without thrombocytopenia have been reported in patients given prophylaxis with fondaparinux?. ### Response: HIT.


Instruction: How many case reports and case series suggest that this agent can be used to treat patients with HIT?

Output: isolated

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many case reports and case series suggest that this agent can be used to treat patients with HIT?. ### Response: isolated.


Instruction: What article discusses this issue in detail?

Output: article on HIT by Linkins et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What article discusses this issue in detail?. ### Response: article on HIT by Linkins et al.


Instruction: Who summarized this supple-ment?

Output: Blackmer et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who summarized this supple-ment?. ### Response: Blackmer et al.


Instruction: When was the American College of Chest Physicians founded?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the American College of Chest Physicians founded?. ### Response: 2012.


Instruction: What is the name of Kimberly Henricks?

Output: American College of Chest Physicians

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of Kimberly Henricks?. ### Response: American College of Chest Physicians.


Instruction: What is the 50th - 90th percentile of MAP targets?

Output: arange

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 50th - 90th percentile of MAP targets?. ### Response: arange.


Instruction: What would be of high value to nearly all well-informed patients or caregivers?

Output: prevention of kidney failure and progressive kidney functionloss

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would be of high value to nearly all well-informed patients or caregivers?. ### Response: prevention of kidney failure and progressive kidney functionloss.


Instruction: What did children with kidneydisease and caregivers rate as important?

Output: kidney function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did children with kidneydisease and caregivers rate as important?. ### Response: kidney function.


Instruction: What was also rated as important by caregivers?

Output: BP control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was also rated as important by caregivers?. ### Response: BP control.


Instruction: Most patients would value clinical bene fits despite the inconvenience and potential risk of what?

Output: aggressive BP management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Most patients would value clinical bene fits despite the inconvenience and potential risk of what?. ### Response: aggressive BP management.


Instruction: What is a potential risk of harms associated with aggressive BP management?

Output: inconvenience

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a potential risk of harms associated with aggressive BP management?. ### Response: inconvenience.


Instruction: What is the burden of monitoring with 24-hourABPM?

Output: expensive

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the burden of monitoring with 24-hourABPM?. ### Response: expensive.


Instruction: Patients for whom medication burden is particularly important may be more inclined not to follow what?

Output: ABPM monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients for whom medication burden is particularly important may be more inclined not to follow what?. ### Response: ABPM monitoring.


Instruction: What may be more inclined not to follow thisrecommendation?

Output: Patients for whom medication burden or theburden of ABPM monitoring are particularly importantconcerns

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be more inclined not to follow thisrecommendation?. ### Response: Patients for whom medication burden or theburden of ABPM monitoring are particularly importantconcerns.


Instruction: What outweighs the costs and inconvenience associated with ABPM?

Output: potential bene ﬁts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What outweighs the costs and inconvenience associated with ABPM?. ### Response: potential bene ﬁts.


Instruction: Where ABPM is unavailable or less affordable will be less inclined to follow this recom-mendation?

Output: Patients and families

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where ABPM is unavailable or less affordable will be less inclined to follow this recom-mendation?. ### Response: Patients and families.


Instruction: What may choose to use clinic-based auscultatoryBP monitoring instead?

Output: Patients and families

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may choose to use clinic-based auscultatoryBP monitoring instead?. ### Response: Patients and families.


Instruction: There are no data that suggest differences inbeneficial effects of BP lowering be-tween males and females or children of different what?

Output: ethnicbackgrounds or races

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There are no data that suggest differences inbeneficial effects of BP lowering be-tween males and females or children of different what?. ### Response: ethnicbackgrounds or races.


Instruction: What are children with proteinuria able to benefit from?

Output: intensive BP lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are children with proteinuria able to benefit from?. ### Response: intensive BP lowering.


Instruction: What is a challenge in implementing ABPM for monitoring treatment of?

Output: hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a challenge in implementing ABPM for monitoring treatment of?. ### Response: hypertension.


Instruction: How long does it take to complete the full 24 hours ofmeasurements?

Output: 366

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take to complete the full 24 hours ofmeasurements?. ### Response: 366.


Instruction: Why are monitors not always available when needed?

Output: they require time from a parent or other adult toreturn the monitor to the clinic and are expensive

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why are monitors not always available when needed?. ### Response: they require time from a parent or other adult toreturn the monitor to the clinic and are expensive.


Instruction: What is a low probability of finding elevated BP by ABPM?

Output: individuals with clinic BP at #25th percentile

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a low probability of finding elevated BP by ABPM?. ### Response: individuals with clinic BP at #25th percentile.


Instruction: What is a lowprobability of finding elevated BP by ABPM?

Output: individuals with clinic BP at #25th percentile

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a lowprobability of finding elevated BP by ABPM?. ### Response: individuals with clinic BP at #25th percentile.


Instruction: Individuals with clinic BP at #25th percentile are unlikely to have elevated what?

Output: ABPM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Individuals with clinic BP at #25th percentile are unlikely to have elevated what?. ### Response: ABPM.


Instruction: How old are children who are too young to undergo ABPM?

Output: <120 centimeters in height

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old are children who are too young to undergo ABPM?. ### Response: <120 centimeters in height.


Instruction: What is important for families to understand how to monitor theirchildren to prevent complications?

Output: for those on ACEi or ARB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is important for families to understand how to monitor theirchildren to prevent complications?. ### Response: for those on ACEi or ARB.


Instruction: What do parents monitor their children to prevent?

Output: complications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do parents monitor their children to prevent?. ### Response: complications.


Instruction: What did the Work Group consider between bene fits and AKI?

Output: balance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Work Group consider between bene fits and AKI?. ### Response: balance.


Instruction: What is part 9 of the 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care?

Output: post-cardiac arrest care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is part 9 of the 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care?. ### Response: post-cardiac arrest care.


Instruction: What is the name of the seventh report of the Joint National Committee on Prevention, Detection, and Treatment of Cardiovascular Disease?

Output: JNC 7 report

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the seventh report of the Joint National Committee on Prevention, Detection, and Treatment of Cardiovascular Disease?. ### Response: JNC 7 report.


Instruction: What was the 7th report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure called?

Output: the JNC 7 report

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 7th report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure called?. ### Response: the JNC 7 report.


Instruction: When did the JNC 7 report come out?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the JNC 7 report come out?. ### Response: 2003.


Instruction: What is the name of the report?

Output: American College of Cardiology Foundation/American Heart Association Task Force on Clinical Data Standards

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the report?. ### Response: American College of Cardiology Foundation/American Heart Association Task Force on Clinical Data Standards.


Instruction: What is the name of the Task Force on Clinical Data Standards?

Output: American College of Cardiology Foundation/American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Clinical Data Standards?. ### Response: American College of Cardiology Foundation/American Heart Association.


Instruction: What is a report of the American College of Cardiology Foundation/American Heart Association?

Output: Task Force on Clinical Data Standards

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a report of the American College of Cardiology Foundation/American Heart Association?. ### Response: Task Force on Clinical Data Standards.


Instruction: What is the acronym for Syndromes and Coronary Artery Disease Clinical Data Standards?

Output: Acute Coronary Syndromes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Syndromes and Coronary Artery Disease Clinical Data Standards?. ### Response: Acute Coronary Syndromes.


Instruction: Circulation. 2013;127:1052–89.

Output: 34

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation. 2013;127:1052–89.. ### Response: 34.


Instruction: What was the name of the Task Force on Clinical Expert Consensus Documents in 2012?

Output: American College of Cardiology Foundation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the Task Force on Clinical Expert Consensus Documents in 2012?. ### Response: American College of Cardiology Foundation.


Instruction: What is the name of the Task Force on Clinical Expert Consensus Documents?

Output: American College of Cardiology Foundation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Clinical Expert Consensus Documents?. ### Response: American College of Cardiology Foundation.


Instruction: When was the J Am Coll Cardiol 60:2427-63?

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol 60:2427-63?. ### Response: 2012.


Instruction: What is a scientific statement from the American Heart Association?

Output: Testing of low-risk patients presenting to the emergency department with chest pain

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a scientific statement from the American Heart Association?. ### Response: Testing of low-risk patients presenting to the emergency department with chest pain.


Instruction: What is the name of the scientific statement from the American Heart Association and the American Diabetes Association?

Output: mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the scientific statement from the American Heart Association and the American Diabetes Association?. ### Response: mellitus.


Instruction: When did Diabetes Care. 2007:30:162–72?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Diabetes Care. 2007:30:162–72?. ### Response: 2007.


Instruction: Who is Harper SA, Fukuda K, Uyeki TM, et al?

Output: 37

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Harper SA, Fukuda K, Uyeki TM, et al?. ### Response: 37.


Instruction: What is the acronym for the Advisory Committee on Immunization Practices?

Output: ACIP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the Advisory Committee on Immunization Practices?. ### Response: ACIP.


Instruction: When was MMWR Recomm Rep.54:1–40?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was MMWR Recomm Rep.54:1–40?. ### Response: 2005.


Instruction: What are the current concepts of the pathogenesis of the acute coronary syn-dromes called?

Output: Libby P

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the current concepts of the pathogenesis of the acute coronary syn-dromes called?. ### Response: Libby P.


Instruction: What type of angina is it time for a requiem?

Output: Unstable

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of angina is it time for a requiem?. ### Response: Unstable.


Instruction: What is the name of the journal that studies the association between hospital process performance and outcomes among acute coronary syndrome patients?

Output: JAMA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies the association between hospital process performance and outcomes among acute coronary syndrome patients?. ### Response: JAMA.


Instruction: What is the TIMI risk score for chest pain?

Output: low

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the TIMI risk score for chest pain?. ### Response: low.


Instruction: Who is the author of Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine?

Output: Benow RO, Braunwalk E

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine?. ### Response: Benow RO, Braunwalk E.


Instruction: What is the TIMI risk score for unstable angina/non-ST elevation MI?

Output: 42

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the TIMI risk score for unstable angina/non-ST elevation MI?. ### Response: 42.


Instruction: What is a method for prognostication and therapeutic decision making?

Output: The TIMI risk score for unstable angina/non-ST elevation MI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a method for prognostication and therapeutic decision making?. ### Response: The TIMI risk score for unstable angina/non-ST elevation MI.


Instruction: When was the JAMA 284:835-42 published?

Output: 2000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the JAMA 284:835-42 published?. ### Response: 2000.


Instruction: How many patients were enrolled in an international trial of ST-segment elevation?

Output: 9461

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were enrolled in an international trial of ST-segment elevation?. ### Response: 9461.


Instruction: Who reported no relevant financial relationships?

Output: Dr Upadhyay

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who reported no relevant financial relationships?. ### Response: Dr Upadhyay.


Instruction: Where is the Tufts Center for Kidney Disease GuidelineDevelopment and Implementation located?

Output: Boston, MA, USA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the Tufts Center for Kidney Disease GuidelineDevelopment and Implementation located?. ### Response: Boston, MA, USA.


Instruction: Who is an Associate Professor of Medicine at Tufts University Schoolof Medicine?

Output: Ethan M Balk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is an Associate Professor of Medicine at Tufts University Schoolof Medicine?. ### Response: Ethan M Balk.


Instruction: Where did Dr. Balk graduate from?

Output: Tufts University Schoolof Medicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where did Dr. Balk graduate from?. ### Response: Tufts University Schoolof Medicine.


Instruction: What did Dr Balk do as Program Director for this guideline?

Output: providing methodological expertise

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Dr Balk do as Program Director for this guideline?. ### Response: providing methodological expertise.


Instruction: What was Dr Balk's primary research interest?

Output: evidence-basedmedicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was Dr Balk's primary research interest?. ### Response: evidence-basedmedicine.


Instruction: What did Balk assist with in the guidelinedevelopment process?

Output: collection, evaluation,grading, and synthesis of evidence and the revisions of theﬁnal evidence report

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Balk assist with in the guidelinedevelopment process?. ### Response: collection, evaluation,grading, and synthesis of evidence and the revisions of theﬁnal evidence report.


Instruction: How did he provide training to Work Group members?

Output: methodologicalguidance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did he provide training to Work Group members?. ### Response: methodologicalguidance.


Instruction: What is Dr Balk's primary research interest?

Output: evidence-basedmedicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Dr Balk's primary research interest?. ### Response: evidence-basedmedicine.


Instruction: Where is Dr Earley a project coordinator?

Output: TuftsCenter for Kidney Disease Guideline Development andImplementation in Boston, MA, USA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Dr Earley a project coordinator?. ### Response: TuftsCenter for Kidney Disease Guideline Development andImplementation in Boston, MA, USA.


Instruction: What is her role at TuftsCenter for Kidney Disease?

Output: project coordinator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is her role at TuftsCenter for Kidney Disease?. ### Response: project coordinator.


Instruction: What city is Earley located in?

Output: Boston

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What city is Earley located in?. ### Response: Boston.


Instruction: What type of review does she head?

Output: actualevidence review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of review does she head?. ### Response: actualevidence review.


Instruction: How does she coordinate guideline development?

Output: withinthe ERT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does she coordinate guideline development?. ### Response: withinthe ERT.


Instruction: Who is a research assistant at the Center?

Output: Shana Haynes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a research assistant at the Center?. ### Response: Shana Haynes.


Instruction: Who reports no relevant financial relationships?

Output: Dr Upadhyay

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who reports no relevant financial relationships?. ### Response: Dr Upadhyay.


Instruction: Who is a research assistant at the TuftsCenter for Kidney Disease Guideline Development and Implementation?

Output: Shana Haynes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a research assistant at the TuftsCenter for Kidney Disease Guideline Development and Implementation?. ### Response: Shana Haynes.


Instruction: Where is the center located?

Output: Boston, MA, USA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the center located?. ### Response: Boston, MA, USA.


Instruction: What does Dr. Haynes assist with?

Output: development of clinical practice guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Dr. Haynes assist with?. ### Response: development of clinical practice guidelines.


Instruction: Who assists in the development of clinical practice guidelines?

Output: Dr Haynes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who assists in the development of clinical practice guidelines?. ### Response: Dr Haynes.


Instruction: What does Dr Haynes conduct?

Output: systematic reviews and critical literatureappraisals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Dr Haynes conduct?. ### Response: systematic reviews and critical literatureappraisals.


Instruction: Who is a project manager and medical writer at Tufts?

Output: Jenny Lamont

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a project manager and medical writer at Tufts?. ### Response: Jenny Lamont.


Instruction: Where is the Center for Kidney Disease Guideline Development and Implementation located?

Output: Boston, MA, USA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the Center for Kidney Disease Guideline Development and Implementation located?. ### Response: Boston, MA, USA.


Instruction: What does Lamont participate in?

Output: all aspects of evidence review and guideline development

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Lamont participate in?. ### Response: all aspects of evidence review and guideline development.


Instruction: What is the name of the book published by NICE 2018?

Output: Chronic Heart Failure  Treating Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the book published by NICE 2018?. ### Response: Chronic Heart Failure  Treating Heart Failure.


Instruction: What was the ISBN number for the clinical benefit of CABG plus medical managemen t?

Output: 978 -1-4731 -3093-7 216

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the ISBN number for the clinical benefit of CABG plus medical managemen t?. ### Response: 978 -1-4731 -3093-7 216.


Instruction: How was the evidence for outcomes from one study rated?

Output: very low

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the evidence for outcomes from one study rated?. ### Response: very low.


Instruction: What was the risk of bias and imprecision?

Output: wide confidence intervals around the effect estimate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk of bias and imprecision?. ### Response: wide confidence intervals around the effect estimate.


Instruction: What was the risk of bias and imprecision due to wide confidence intervals around the effect estimate?

Output: very low

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk of bias and imprecision due to wide confidence intervals around the effect estimate?. ### Response: very low.


Instruction: Evidence for the outcome all -cause mortality showed a clinically important harm of the invasive strategy?

Output: wide confidence intervals around the effect estimate

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Evidence for the outcome all -cause mortality showed a clinically important harm of the invasive strategy?. ### Response: wide confidence intervals around the effect estimate.


Instruction: What were the wide confidence intervals around the effect estimate?

Output: Evidence for the outcome all -cause mortality showed a clinically important harm of the invasive strategy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the wide confidence intervals around the effect estimate?. ### Response: Evidence for the outcome all -cause mortality showed a clinically important harm of the invasive strategy.


Instruction: Evidence for the outcome QoL as measured by the EQ -5D and MLWHF showed no clinical important effect?

Output: No evidence was found for improvement in ejection fraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Evidence for the outcome QoL as measured by the EQ -5D and MLWHF showed no clinical important effect?. ### Response: No evidence was found for improvement in ejection fraction.


Instruction: No evidence was found for improvement in what?

Output: ejection fraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No evidence was found for improvement in what?. ### Response: ejection fraction.


Instruction: Economic  No relevant economic evaluations were identified.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Economic  No relevant economic evaluations were identified.. ### Response: .


Instruction: What is the risk of future coronary events in kidney transplant recipients markedly elevated?

Output: data from the placebo arm ofthe ALERT trial suggest that the rate of cardiovascular deathor non-fatal MI is approximately 21.5 per 1000 patient-years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of future coronary events in kidney transplant recipients markedly elevated?. ### Response: data from the placebo arm ofthe ALERT trial suggest that the rate of cardiovascular deathor non-fatal MI is approximately 21.5 per 1000 patient-years.


Instruction: Data from the placebo arm of the ALERT trial suggest that the rate of cardiovascular death or non-fatal MI is approximately 21.5 per 1000 patient-years?

Output: 48

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Data from the placebo arm of the ALERT trial suggest that the rate of cardiovascular death or non-fatal MI is approximately 21.5 per 1000 patient-years?. ### Response: 48.


Instruction: What is not available for kidney transplant recipients?

Output: Data on the rate of non-fatal MI by age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not available for kidney transplant recipients?. ### Response: Data on the rate of non-fatal MI by age.


Instruction: What is the rate of cardiovascular death alone?

Output: 5 per1000 patient-years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the rate of cardiovascular death alone?. ### Response: 5 per1000 patient-years.


Instruction: How old were the 2102 patients treated with statins?

Output: 30– 75 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old were the 2102 patients treated with statins?. ### Response: 30– 75 years.


Instruction: How long were the patients followed by ALERT?

Output: 5– 6years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long were the patients followed by ALERT?. ### Response: 5– 6years.


Instruction: What is the daily dose of fluvastatin?

Output: 40– 80 mg/day

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the daily dose of fluvastatin?. ### Response: 40– 80 mg/day.


Instruction: What did fluvastatin therapy reduce the primary outcome of?

Output: coronarydeath or non-fatal MI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did fluvastatin therapy reduce the primary outcome of?. ### Response: coronarydeath or non-fatal MI.


Instruction: What was the RR of placebo?

Output: 0.83

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the RR of placebo?. ### Response: 0.83.


Instruction: How much was the reduction in the risk of cardiac death or definite non-fatal MI?

Output: 35%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much was the reduction in the risk of cardiac death or definite non-fatal MI?. ### Response: 35%.


Instruction: What is the risk of cardiac death or definite non-fatal MI?

Output: 35%relative reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of cardiac death or definite non-fatal MI?. ### Response: 35%relative reduction.


Instruction: What was associated with a significant reduction in the original primary outcome after 6.7 years of follow-up?

Output: randomization to ﬂuvastatin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with a significant reduction in the original primary outcome after 6.7 years of follow-up?. ### Response: randomization to ﬂuvastatin.


Instruction: What do the apparent benefits observed in ALERT are consistent with?

Output: the effects of statins in the general population

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do the apparent benefits observed in ALERT are consistent with?. ### Response: the effects of statins in the general population.


Instruction: What suggest that statins are beneficial in patients with afunctioning kidney transplant?

Output: clinical trial data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What suggest that statins are beneficial in patients with afunctioning kidney transplant?. ### Response: clinical trial data.


Instruction: The nominal lack ofstatistical significance in the primary analysis and the existence of a single randomized trial favor what?

Output: a weak recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The nominal lack ofstatistical significance in the primary analysis and the existence of a single randomized trial favor what?. ### Response: a weak recommendation.


Instruction: What does analysis and the existence of a single randomized trial favor?

Output: a weak recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does analysis and the existence of a single randomized trial favor?. ### Response: a weak recommendation.


Instruction: What is the age at which statin treatment should begin in kidneytransplant recipients?

Output: 30– 75 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the age at which statin treatment should begin in kidneytransplant recipients?. ### Response: 30– 75 years.


Instruction: What is ESRD treated by?

Output: kidneytransplantation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ESRD treated by?. ### Response: kidneytransplantation.


Instruction: What is the cardiovascular risk expected to increase over time even in the presence ofoptimal graft function?

Output: ESRD treated by kidneytransplantation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cardiovascular risk expected to increase over time even in the presence ofoptimal graft function?. ### Response: ESRD treated by kidneytransplantation.


Instruction: In the judgment of the WorkGroup, these considerations warrant treatment in all adult kidney transplant recipients?

Output: ESRD treated by kidneytransplantation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the judgment of the WorkGroup, these considerations warrant treatment in all adult kidney transplant recipients?. ### Response: ESRD treated by kidneytransplantation.


Instruction: Who could choose not to receive statintreatment if they placed less value on a smallabsolute reduction in the risk of cardiovascular events and more value onminimizing the risks of poly-pharmacy and drug toxicity?

Output: younger patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who could choose not to receive statintreatment if they placed less value on a smallabsolute reduction in the risk of cardiovascular events and more value onminimizing the risks of poly-pharmacy and drug toxicity?. ### Response: younger patients.


Instruction: What are some Asian countries' doses of statins lower than those used in Western countries?

Output: lower thanthose used in Western countries, due to concern about drugtoxicity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some Asian countries' doses of statins lower than those used in Western countries?. ### Response: lower thanthose used in Western countries, due to concern about drugtoxicity.


Instruction: Why are dosesof statin lower than Western countries'?

Output: concern about drugtoxicity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why are dosesof statin lower than Western countries'?. ### Response: concern about drugtoxicity.


Instruction: What may physicians in Asian countries choose to prescribe lower doses?

Output: statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may physicians in Asian countries choose to prescribe lower doses?. ### Response: statins.


Instruction: What may physicians choose to prescribe lower doses than recommended in Table 4?

Output: statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may physicians choose to prescribe lower doses than recommended in Table 4?. ### Response: statins.


Instruction: What is the short title of the 2017 AHA/ACC STEMI/NSTEMI Measure Set?

Output: QM-3: Therapeutic Hypothermia for STEMI Patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the short title of the 2017 AHA/ACC STEMI/NSTEMI Measure Set?. ### Response: QM-3: Therapeutic Hypothermia for STEMI Patients.


Instruction: What does QM-3: STEMI: Therapeutic Hypothermia for Comatose STEMI Patients With Out-of-Hospital Cardiac Arrest measure?

Output: Percentage of patients, age ≥18 y, with STEMI who become comatose after resuscitated out-of-hospital cardiac arrest (secondary to VF or pulseless VT) and who receive therapeutic hypothermia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does QM-3: STEMI: Therapeutic Hypothermia for Comatose STEMI Patients With Out-of-Hospital Cardiac Arrest measure?. ### Response: Percentage of patients, age ≥18 y, with STEMI who become comatose after resuscitated out-of-hospital cardiac arrest (secondary to VF or pulseless VT) and who receive therapeutic hypothermia.


Instruction: Who is comatose after resuscitated out-of-hospital cardiac arrest?

Output: All patients with STEMI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is comatose after resuscitated out-of-hospital cardiac arrest?. ### Response: All patients with STEMI.


Instruction: Who receives therapeutic hypothermia?

Output: comatose patients with STEMI and out-of-hospital cardiac arrest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who receives therapeutic hypothermia?. ### Response: comatose patients with STEMI and out-of-hospital cardiac arrest.


Instruction: What is defined by characteristic symptoms of myocardial ischemia?

Output: VF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is defined by characteristic symptoms of myocardial ischemia?. ### Response: VF.


Instruction: What type of hypothermia is used after resuscitated out-of-hospital cardiac arrest?

Output: VF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of hypothermia is used after resuscitated out-of-hospital cardiac arrest?. ### Response: VF.


Instruction: What may patients with STEMI equivalent on ECG have?

Output: hyperacute T-wave changes, true posterior MI, multilead ST depression

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may patients with STEMI equivalent on ECG have?. ### Response: hyperacute T-wave changes, true posterior MI, multilead ST depression.


Instruction: What is the name of the setting of LBBB?

Output: left bundle branch block

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the setting of LBBB?. ### Response: left bundle branch block.


Instruction: All patients with STEMI who are comatose after resuscitated out-of-hospital cardiac arrest (VF or pulseless VT)?

Output: Denominator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: All patients with STEMI who are comatose after resuscitated out-of-hospital cardiac arrest (VF or pulseless VT)?. ### Response: Denominator.


Instruction: Patients who die shortly after arrival (12 h)Patients who become comfort care measures only or what?

Output: hospice

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients who die shortly after arrival (12 h)Patients who become comfort care measures only or what?. ### Response: hospice.


Instruction: What is a medical reason for not receiving therapeutic hypothermia for comatose STEMI patients with out-of-hospital cardiac arrest?

Output: ventricular fibrillation (VF) or pulseless ventricular tachycardia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a medical reason for not receiving therapeutic hypothermia for comatose STEMI patients with out-of-hospital cardiac arrest?. ### Response: ventricular fibrillation (VF) or pulseless ventricular tachycardia.


Instruction: How long after arrival are patients transferred to another hospital for inpatient care?

Output: (<12 h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after arrival are patients transferred to another hospital for inpatient care?. ### Response: (<12 h.


Instruction: What type of STEMI patients have out-of-hospital cardiac arrest?

Output: comatose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of STEMI patients have out-of-hospital cardiac arrest?. ### Response: comatose.


Instruction: What is a measure reportable at the facility or provider level?

Output: Attribution

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a measure reportable at the facility or provider level?. ### Response: Attribution.


Instruction: What type of hypothermia has been shown to improve outcomes in comatose patients with acute MI?

Output: Therapeutic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of hypothermia has been shown to improve outcomes in comatose patients with acute MI?. ### Response: Therapeutic.


Instruction: What should be started as soon as possible in comatose patients with STEMI and out-of-hospital cardiac arrest?

Output: Therapeutic hypothermia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be started as soon as possible in comatose patients with STEMI and out-of-hospital cardiac arrest?. ### Response: Therapeutic hypothermia.


Instruction: What is the 2013 ACCF/AHA Guideline for the Management of Patients With ST-Elevation Myocardial Infarction?

Output: Clinical Recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2013 ACCF/AHA Guideline for the Management of Patients With ST-Elevation Myocardial Infarction?. ### Response: Clinical Recommendation.


Instruction: What does VF stand for?

Output: ventricular fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does VF stand for?. ### Response: ventricular fibrillation.


Instruction: What is VT also known as?

Output: pulseless ventricular tachycardia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is VT also known as?. ### Response: pulseless ventricular tachycardia.


Instruction: Who is the American College of Cardiology Foundation?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the American College of Cardiology Foundation?. ### Response: American Heart Association.


Instruction: What is the acronym for left bundle branch block?

Output: LBBB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for left bundle branch block?. ### Response: LBBB.


Instruction: What is MI?

Output: myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is MI?. ### Response: myocardial infarction.


Instruction: What is the CD003041.651?

Output: Helping smokers with cardiac disease to abstain fromtobacco after a stay in hospital

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the CD003041.651?. ### Response: Helping smokers with cardiac disease to abstain fromtobacco after a stay in hospital.


Instruction: Who helped smokers with cardiac disease to abstain from smoking after a stay in hospital?

Output: Hughes JR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who helped smokers with cardiac disease to abstain from smoking after a stay in hospital?. ### Response: Hughes JR.


Instruction: What is a randomized controlled trial for patients with coronary artery disease?

Output: Smoking cessation initiated during hospital stay

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a randomized controlled trial for patients with coronary artery disease?. ### Response: Smoking cessation initiated during hospital stay.


Instruction: How old was Peto?

Output: 20 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old was Peto?. ### Response: 20 years.


Instruction: How old were male British doctors in relation to smoking?

Output: 20 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old were male British doctors in relation to smoking?. ### Response: 20 years.


Instruction: What year did Peto retire?

Output: 1974

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Peto retire?. ### Response: 1974.


Instruction: When was the last year of Peto's retirement?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last year of Peto's retirement?. ### Response: 2005.


Instruction: What is the name of the study that analyzed smoking and risk of cardiovascular disease?

Output: Fra-mingham Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that analyzed smoking and risk of cardiovascular disease?. ### Response: Fra-mingham Study.


Instruction: What did the Fra-mingham Study reveal about smoking and cardiovascular disease in 1987?

Output: Fibrinogen, cig arettesmoking, and risk of cardiovascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Fra-mingham Study reveal about smoking and cardiovascular disease in 1987?. ### Response: Fibrinogen, cig arettesmoking, and risk of cardiovascular disease.


Instruction: How did cigarettes increase platelet function?

Output: —induced enhancement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did cigarettes increase platelet function?. ### Response: —induced enhancement.


Instruction: What did aspirinin men with coronary artery disease lack of?

Output: prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did aspirinin men with coronary artery disease lack of?. ### Response: prevention.


Instruction: What did cigarette smoking do to endothelium-dependent coronary arterial vasodilator function?

Output: impairs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did cigarette smoking do to endothelium-dependent coronary arterial vasodilator function?. ### Response: impairs.


Instruction: What is the name of the position paper from the Council on Cardio-pulmonary and Critical Care, American Heart Association?

Output: 86:699–702.659

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the position paper from the Council on Cardio-pulmonary and Critical Care, American Heart Association?. ### Response: 86:699–702.659.


Instruction: When was the Circulation.86:699–702.659 published?

Output: 1992

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circulation.86:699–702.659 published?. ### Response: 1992.


Instruction: What is nitroglycerin and calcium antagonists used for?

Output: prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is nitroglycerin and calcium antagonists used for?. ### Response: prevention.


Instruction: How soon after quitting smoking does risk of heart attack decline?

Output: 44:1247–53.661

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How soon after quitting smoking does risk of heart attack decline?. ### Response: 44:1247–53.661.


Instruction: What study did Gordon T, Kannel WB, McGee D, et al. report on?

Output: Framinghamstudy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What study did Gordon T, Kannel WB, McGee D, et al. report on?. ### Response: Framinghamstudy.


Instruction: What is a report from the Framinghamstudy?

Output: Death and coronary attacks inmen after giving up cigarette smoking

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a report from the Framinghamstudy?. ### Response: Death and coronary attacks inmen after giving up cigarette smoking.


Instruction: What is the name of the study that investigated cigarette smoking?

Output: Fra-mingham Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated cigarette smoking?. ### Response: Fra-mingham Study.


Instruction: How did the researchers evaluate the efficacy of tobacco counseling by health care providers?

Output: Meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did the researchers evaluate the efficacy of tobacco counseling by health care providers?. ### Response: Meta-analysis.


Instruction: What is the Cochrane Database Syst Rev. 2005;CD001292.665?

Output: Individual behavioural counselling for smokingcessation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Cochrane Database Syst Rev. 2005;CD001292.665?. ### Response: Individual behavioural counselling for smokingcessation.


Instruction: What does Stead LF, Lancaster T, Perera R do for smokingcessation?

Output: Telephone counselling

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Stead LF, Lancaster T, Perera R do for smokingcessation?. ### Response: Telephone counselling.


Instruction: What year did Cochrane Database Syst Rev. 2003 have a CD002850.667?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Cochrane Database Syst Rev. 2003 have a CD002850.667?. ### Response: 2005.


Instruction: What did Ussher M say about exercise interventions for smoking cessation?

Output: Exercise interventions for smoking cessation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Ussher M say about exercise interventions for smoking cessation?. ### Response: Exercise interventions for smoking cessation.


Instruction: How did Silagy C, Lancaster T, Stead L, et al. feel about nicotine replacement therapy?

Output: smoking cessation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Silagy C, Lancaster T, Stead L, et al. feel about nicotine replacement therapy?. ### Response: smoking cessation.


Instruction: What should pregnant women with mechanical prostheses receive during pregnancy?

Output: therapeutic anticoagulation with frequent monitoring

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should pregnant women with mechanical prostheses receive during pregnancy?. ### Response: therapeutic anticoagulation with frequent monitoring.


Instruction: What should women who have mechanical heart valves receive?

Output: therapeutic anticoagulation with frequent monitoring during pregnancy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should women who have mechanical heart valves receive?. ### Response: therapeutic anticoagulation with frequent monitoring during pregnancy.


Instruction: Who should receive therapeutic anticoagulation?

Output: Pregnant women with mechanical prostheses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should receive therapeutic anticoagulation?. ### Response: Pregnant women with mechanical prostheses.


Instruction: What should women with mechanical heart valves not maintain with frequent monitoring be counseled against?

Output: therapeutic anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should women with mechanical heart valves not maintain with frequent monitoring be counseled against?. ### Response: therapeutic anticoagulation.


Instruction: What should be used to choose an anticoagulation strategy for pregnancy?

Output: shared decision-making

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be used to choose an anticoagulation strategy for pregnancy?. ### Response: shared decision-making.


Instruction: What should women be informed about during pregnancy?

Output: VKA during pregnancy is associated with the lowest likelihood of maternal complications but the highest likelihood of miscarriage, fetal death, and congenital abnormalities

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should women be informed about during pregnancy?. ### Response: VKA during pregnancy is associated with the lowest likelihood of maternal complications but the highest likelihood of miscarriage, fetal death, and congenital abnormalities.


Instruction: What is associated with the lowest likelihood of maternal complications but the highest likelihood of miscarriage, fetal death and congenital abnormalities?

Output: VKA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with the lowest likelihood of maternal complications but the highest likelihood of miscarriage, fetal death and congenital abnormalities?. ### Response: VKA.


Instruction: What is the target anti-Xa level of LMWH?

Output: 0.8 to 1.2 U/mL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the target anti-Xa level of LMWH?. ### Response: 0.8 to 1.2 U/mL.


Instruction: What should women with mechanical valve prostheses switch to?

Output: UFH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should women with mechanical valve prostheses switch to?. ### Response: UFH.


Instruction: How often should women who are on warfarin switch to intravenous UFH?

Output: 1 week

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How often should women who are on warfarin switch to intravenous UFH?. ### Response: 1 week.