Instruction: What is a high-risk combination of acute myocardial infarctionand renal dysfunction?

Output: Wright RS, Reeder GS, Herzog CA, et al. Acute myocardial infarctionand renal dysfunction: a high-risk combination. Ann Intern Med. 2002;137:563–70.163

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a high-risk combination of acute myocardial infarctionand renal dysfunction?. ### Response: Wright RS, Reeder GS, Herzog CA, et al. Acute myocardial infarctionand renal dysfunction: a high-risk combination. Ann Intern Med. 2002;137:563–70.163.


Instruction: What is the name of the TACTICS-TIMI 18 Trial?

Output: Effects of renal insufficiencyon early invasive management in patients with acute coronary syndromes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the TACTICS-TIMI 18 Trial?. ### Response: Effects of renal insufficiencyon early invasive management in patients with acute coronary syndromes.


Instruction: What is a high-risk combination?

Output: Acute myocardial infarctionand renal dysfunction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a high-risk combination?. ### Response: Acute myocardial infarctionand renal dysfunction.


Instruction: What is an association of renalinsufficiency with treatment and outcomes after myocardial infarction inelderly patients?

Output: Shlipak

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an association of renalinsufficiency with treatment and outcomes after myocardial infarction inelderly patients?. ### Response: Shlipak.


Instruction: What is the name of the study that investigated sexual intercourse and risk of ischaemic stroke and coronary heart disease?

Output: Caerphilly study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated sexual intercourse and risk of ischaemic stroke and coronary heart disease?. ### Response: Caerphilly study.


Instruction: What study was conducted in 2002?

Output: Caerphilly study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What study was conducted in 2002?. ### Response: Caerphilly study.


Instruction: When was the Caerphilly study conducted?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Caerphilly study conducted?. ### Response: 2002.


Instruction: What is the association of episodic physical and sexualactivity with triggering of acute cardiac events?

Output: systematic review andmeta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association of episodic physical and sexualactivity with triggering of acute cardiac events?. ### Response: systematic review andmeta-analysis.


Instruction: What is a systematic review andmeta-analysis?

Output: Association of episodic physical and sexualactivity with triggering of acute cardiac events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a systematic review andmeta-analysis?. ### Response: Association of episodic physical and sexualactivity with triggering of acute cardiac events.


Instruction: Who is the author of Sexual activity and cardiac risk?

Output: Cheitlin MD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of Sexual activity and cardiac risk?. ### Response: Cheitlin MD.


Instruction: When was the Am J Cardiol 96:24M–8M?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Am J Cardiol 96:24M–8M?. ### Response: 2005.


Instruction: How many antihypertensive drugs have been shown to have long-term effects on sexual function?

Output: five

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many antihypertensive drugs have been shown to have long-term effects on sexual function?. ### Response: five.


Instruction: What is the TOMHS study called?

Output: Treatment of Mild Hyper-tension Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the TOMHS study called?. ### Response: Treatment of Mild Hyper-tension Study.


Instruction: How many drugs did Dusing use to treat sexual dysfunction in men with hypertension?

Output: five

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many drugs did Dusing use to treat sexual dysfunction in men with hypertension?. ### Response: five.


Instruction: Drugs. 2005;65:773–86.490.

Output: hypertensive drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Drugs. 2005;65:773–86.490.. ### Response: hypertensive drugs.


Instruction: What is the name of the study that investigated the effects of beta-blockers on sexual performance in men with coronary heart disease?

Output: Int J Impot Res.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the effects of beta-blockers on sexual performance in men with coronary heart disease?. ### Response: Int J Impot Res..


Instruction: What is a systematic analysis of cardiovascular risk, drugs, and erectile function?

Output: Int J Clin Pract.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a systematic analysis of cardiovascular risk, drugs, and erectile function?. ### Response: Int J Clin Pract..


Instruction: What is a systematic analysis of cardiovascular risk, drugs and erectile function?

Output: Int J Clin Pract.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a systematic analysis of cardiovascular risk, drugs and erectile function?. ### Response: Int J Clin Pract..


Instruction: What is the name of the drug used to treat depression, fatigue, and sexual dysfunction?

Output: Beta-blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used to treat depression, fatigue, and sexual dysfunction?. ### Response: Beta-blocker.


Instruction: How long did it take to update the safety of sildenafil citrate?

Output: 4-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take to update the safety of sildenafil citrate?. ### Response: 4-year.


Instruction: What is tadalafil used for in the treatment of erectile dysfunction?

Output: Long-term safety andtolerability

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is tadalafil used for in the treatment of erectile dysfunction?. ### Response: Long-term safety andtolerability.


Instruction: What is the phosphodiesterase 5 inhibitor of?

Output: tadalafil

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the phosphodiesterase 5 inhibitor of?. ### Response: tadalafil.


Instruction: How long did it take for sildenafil citrate to be safe?

Output: 4-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for sildenafil citrate to be safe?. ### Response: 4-year.


Instruction: What is the phosphodiesterase 5 inhibitor tadalafil?

Output: Interaction between thephosphodiesterase 5 inhibitor, tadalafil and 2 alpha-blockers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the phosphodiesterase 5 inhibitor tadalafil?. ### Response: Interaction between thephosphodiesterase 5 inhibitor, tadalafil and 2 alpha-blockers.


Instruction: What are the alpha-blockers dox-azosin and tamsulosin?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the alpha-blockers dox-azosin and tamsulosin?. ### Response: 2.


Instruction: When was the J Urol 172:1935–40.496 published?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Urol 172:1935–40.496 published?. ### Response: 2004.


Instruction: How does weight reduction affect bloodlipids and lipoprotein?

Output: Effects of weight reduction on bloodlipids and lipoproteins: a meta-analysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does weight reduction affect bloodlipids and lipoprotein?. ### Response: Effects of weight reduction on bloodlipids and lipoproteins: a meta-analysis.


Instruction: What is the name of the study that examined the effects of reducing saturated fatty acids on plasma lipids and lipoproteins in healthy subjects?

Output: DELTA Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined the effects of reducing saturated fatty acids on plasma lipids and lipoproteins in healthy subjects?. ### Response: DELTA Study.


Instruction: What was the protocol of the DELTA Study?

Output: protocol 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the protocol of the DELTA Study?. ### Response: protocol 1.


Instruction: When was the Arterioscler ThrombVasc Biol. 18:441–9.498?

Output: 1998

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Arterioscler ThrombVasc Biol. 18:441–9.498?. ### Response: 1998.


Instruction: What is the lipoprotein cholesterol response to National Cholesterol Education Program Step 2 diets?

Output: Individual variability

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the lipoprotein cholesterol response to National Cholesterol Education Program Step 2 diets?. ### Response: Individual variability.


Instruction: What was the Am J Clin Nutr. 1997;65:823–30.499.

Output: National Cholesterol EducationProgram Step 2 diets

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the Am J Clin Nutr. 1997;65:823–30.499.. ### Response: National Cholesterol EducationProgram Step 2 diets.


Instruction: What did Schaefer EJ, Lichtenstein AH, Lamon-Fava S, et al. find in normolipidemic middle-aged and elderly men and women?

Output: Efficacy of aNational Cholesterol Education Program Step 2 diet

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Schaefer EJ, Lichtenstein AH, Lamon-Fava S, et al. find in normolipidemic middle-aged and elderly men and women?. ### Response: Efficacy of aNational Cholesterol Education Program Step 2 diet.


Instruction: What is the name of the study that examined the effects of the National Choles-Barrel Association?

Output: DELTA Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that examined the effects of the National Choles-Barrel Association?. ### Response: DELTA Study.


Instruction: When was Arterioscler Thromb Vasc Biol 15:1079–85.500 published?

Output: 1995

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Arterioscler Thromb Vasc Biol 15:1079–85.500 published?. ### Response: 1995.


Instruction: What are the risks of doubling of SCrlevel, kidney failure, or death?

Output: hard’ outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the risks of doubling of SCrlevel, kidney failure, or death?. ### Response: hard’ outcomes.


Instruction: Patients with macroalbuminuria are at very high risk for both progression of CKD and development of what?

Output: CVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with macroalbuminuria are at very high risk for both progression of CKD and development of what?. ### Response: CVD.


Instruction: What do ACE-Is and ARBs reduce the risk of?

Output: macroalbuminuria, doubling of creatinine levels, and devel-opment of kidney failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do ACE-Is and ARBs reduce the risk of?. ### Response: macroalbuminuria, doubling of creatinine levels, and devel-opment of kidney failure.


Instruction: What are the results of RCTs in patients with CKD of various causes?

Output: most of the data are fromsubgroup analyses of CKD patients from general populationstudies. Several analyses have shown a beneﬁt of ACE-Isor ARBs over placebo or another agent, and although most ofthese studies were performed in patients with urine albuminlevels below the macroalbuminuria cutoff, there is noobvious reason why the beneﬁt would not extend toindividuals with macroalbuminuria (Supplementary Tables7– 12 online).In summary, the data in support of the use of ACE-Is orARBs are reasonably strong for preventing progression ofCKD and less so for CVD protection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of RCTs in patients with CKD of various causes?. ### Response: most of the data are fromsubgroup analyses of CKD patients from general populationstudies. Several analyses have shown a beneﬁt of ACE-Isor ARBs over placebo or another agent, and although most ofthese studies were performed in patients with urine albuminlevels below the macroalbuminuria cutoff, there is noobvious reason why the beneﬁt would not extend toindividuals with macroalbuminuria (Supplementary Tables7– 12 online).In summary, the data in support of the use of ACE-Is orARBs are reasonably strong for preventing progression ofCKD and less so for CVD protection.


Instruction: How many African-Americans have hypertension?

Output: 191

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many African-Americans have hypertension?. ### Response: 191.


Instruction: What is the aGFR of patients with advanced CKD?

Output: 20– 70 ml/min/1.73 m2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the aGFR of patients with advanced CKD?. ### Response: 20– 70 ml/min/1.73 m2.


Instruction: How many RCTs did a meta-analysis of in-dividual patient data compare?

Output: 11

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs did a meta-analysis of in-dividual patient data compare?. ### Response: 11.


Instruction: What was the HR of ACE-Is for kidney failure?

Output: 0.69

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the HR of ACE-Is for kidney failure?. ### Response: 0.69.


Instruction: What was the HR of patients with kidney failure?

Output: 0.69

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the HR of patients with kidney failure?. ### Response: 0.69.


Instruction: What is the HR for patients with combined outcome of doubling baseline SCrconcentration?

Output: 0.70

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the HR for patients with combined outcome of doubling baseline SCrconcentration?. ### Response: 0.70.


Instruction: Patients with greater urinary protein excretion at baseline benefited more from what?

Output: ACE-I therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with greater urinary protein excretion at baseline benefited more from what?. ### Response: ACE-I therapy.


Instruction: What did the Work Group not find with regard to the benefit of ACE-Is according to CKD stage?

Output: heterogeneity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the Work Group not find with regard to the benefit of ACE-Is according to CKD stage?. ### Response: heterogeneity.


Instruction: What did few RCTs with hard CVD or kidney-disease outcomesrandomized patients to?

Output: a diuretic or another agent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did few RCTs with hard CVD or kidney-disease outcomesrandomized patients to?. ### Response: a diuretic or another agent.


Instruction: What did one RCT in individuals predominantly without CKD show?

Output: the risk of doubling of the creatinine level washigher with an ACE-I–hydrochlorothiazide combination thanwith ACE-I–amlodipine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did one RCT in individuals predominantly without CKD show?. ### Response: the risk of doubling of the creatinine level washigher with an ACE-I–hydrochlorothiazide combination thanwith ACE-I–amlodipine.


Instruction: What was higher with an ACE-I-hydrochlorothiazide combination thanwith ace-I–amlodipine?

Output: creatinine level

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was higher with an ACE-I-hydrochlorothiazide combination thanwith ace-I–amlodipine?. ### Response: creatinine level.


Instruction: What was higher with an ACE-I-hydrochlorothiazide combination than with ACE I-amlodipine?

Output: creatinine level

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was higher with an ACE-I-hydrochlorothiazide combination than with ACE I-amlodipine?. ### Response: creatinine level.


Instruction: What remains to be determined as it may reflect areversible hemodynamic effect?

Output: The clinical importance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What remains to be determined as it may reflect areversible hemodynamic effect?. ### Response: The clinical importance.


Instruction: There is only limited evidence evaluating differences in what?

Output: ACE-I versusARB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is only limited evidence evaluating differences in what?. ### Response: ACE-I versusARB.


Instruction: How many RCTs of BP agents have focused on CVD outcomes in subjects with CKD?

Output: Only a few

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs of BP agents have focused on CVD outcomes in subjects with CKD?. ### Response: Only a few.


Instruction: What are most of the data from?

Output: ACE-I therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are most of the data from?. ### Response: ACE-I therapy.


Instruction: What have several analyses shown a benefit of ACE-Isor ARBs over placebo or another agent?

Output: reducing the risk ofmacroalbuminuria, doubling of creatinine levels, and devel-opment of kidney failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have several analyses shown a benefit of ACE-Isor ARBs over placebo or another agent?. ### Response: reducing the risk ofmacroalbuminuria, doubling of creatinine levels, and devel-opment of kidney failure.


Instruction: Most studies were performed in patients with urine albumin levels below what?

Output: macroalbuminuria cutoff

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Most studies were performed in patients with urine albumin levels below what?. ### Response: macroalbuminuria cutoff.


Instruction: What do the data in support of the use of ACE-Is orARBs show?

Output: reasonably strong for preventing progression ofCKD and less so for CVD protection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do the data in support of the use of ACE-Is orARBs show?. ### Response: reasonably strong for preventing progression ofCKD and less so for CVD protection.


Instruction: What are reasonably strong for preventing progression ofCKD and less so for CVD protection?

Output: ACE-Is orARBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are reasonably strong for preventing progression ofCKD and less so for CVD protection?. ### Response: ACE-Is orARBs.


Instruction: Preventing and manag ing postoper ative atrial fi brillation 1.10.1 In people ha ving car diothoracic surgery: • reduce t he risk of post operativ e atrial fibrillation b y off ering 1 of the following: - amiodar one - what?

Output: 1.10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Preventing and manag ing postoper ative atrial fi brillation 1.10.1 In people ha ving car diothoracic surgery: • reduce t he risk of post operativ e atrial fibrillation b y off ering 1 of the following: - amiodar one - what?. ### Response: 1.10.


Instruction: What is a beta-blocker ot her t han sotalol?

Output: standar d beta-block er

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a beta-blocker ot her t han sotalol?. ### Response: standar d beta-block er.


Instruction: What is another name for a rat e-limiting calcium-channel block er?

Output: diltiaz em or v erapamil

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for a rat e-limiting calcium-channel block er?. ### Response: diltiaz em or v erapamil.


Instruction: When was digo xin amended?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was digo xin amended?. ### Response: 2014.


Instruction: What was the off -label use of diltiaz em in April 2021?

Output: rat e-limiting calcium-channel block er

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the off -label use of diltiaz em in April 2021?. ### Response: rat e-limiting calcium-channel block er.


Instruction: What is NICE's inf ormation on prescribing medicines?

Output: 1.10.2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE's inf ormation on prescribing medicines?. ### Response: 1.10.2.


Instruction: What should a person who is already on beta-block er therapy do?

Output: continue t his tr eatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should a person who is already on beta-block er therapy do?. ### Response: continue t his tr eatment.


Instruction: What is a contraindication to continue his treatment unless he has what?

Output: de velop

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a contraindication to continue his treatment unless he has what?. ### Response: de velop.


Instruction: Do not star t statins in people who have car diothoracic surgery solely t o prevent post operative bradycardia or h ypotension?

Output: do not off er digo xin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Do not star t statins in people who have car diothoracic surgery solely t o prevent post operative bradycardia or h ypotension?. ### Response: do not off er digo xin.


Instruction: What is the sole purpose of ving car diothoracic surgery?

Output: reduce t he risk of post operativ e atrial fibrillation b y off ering 1  of the following: － amiodar one － a standar d beta-block er (that is, a beta-block er ot her t han sotalol) － a rat e-limiting calcium-channel block er (diltiaz em or v erapamil) • do not off er digo xin. [2006 , amended 2014] In April 2021 , this was an off -label use of diltiaz em. See NICE's inf ormation on prescribing medicines . 1.10.2 In people ha ving car diothoracic sur gery who ar e already on beta-block er therap y, continue t his tr eatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the sole purpose of ving car diothoracic surgery?. ### Response: reduce t he risk of post operativ e atrial fibrillation b y off ering 1  of the following: － amiodar one － a standar d beta-block er (that is, a beta-block er ot her t han sotalol) － a rat e-limiting calcium-channel block er (diltiaz em or v erapamil) • do not off er digo xin. [2006 , amended 2014] In April 2021 , this was an off -label use of diltiaz em. See NICE's inf ormation on prescribing medicines . 1.10.2 In people ha ving car diothoracic sur gery who ar e already on beta-block er therap y, continue t his tr eatment.


Instruction: What should people who are already on statins continue to his treatment?

Output: continue t his tr eatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should people who are already on statins continue to his treatment?. ### Response: continue t his tr eatment.


Instruction: What is NICE's guideline on car diovascular disease: risk assessment and r eduction?

Output: prescribing medicines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE's guideline on car diovascular disease: risk assessment and r eduction?. ### Response: prescribing medicines.


Instruction: Atrial fibrillation: diagnosis and management (NG196) NICE 2022.

Output: All right s reserved

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Atrial fibrillation: diagnosis and management (NG196) NICE 2022.. ### Response: All right s reserved.


Instruction: What is the last updat ed 30 June 2021Page 23of 47?

Output: Notice of right s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the last updat ed 30 June 2021Page 23of 47?. ### Response: Notice of right s.


Instruction: What did Rigotti NA, Munafo MR, Stead LF say about smoking cessation interventions for hospitalized smokers?

Output: a systematic review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Rigotti NA, Munafo MR, Stead LF say about smoking cessation interventions for hospitalized smokers?. ### Response: a systematic review.


Instruction: What did Smith PM, Burgess E think about smoking Cessation initiated during hospital stay for patients with coronary artery disease?

Output: randomized controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Smith PM, Burgess E think about smoking Cessation initiated during hospital stay for patients with coronary artery disease?. ### Response: randomized controlled trial.


Instruction: How long did the CASS follow-up last?

Output: 10–year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the CASS follow-up last?. ### Response: 10–year.


Instruction: What is the name of the study that investigated the effects of smoking on survival and morbidity?

Output: Coronary Artery Surgery Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the effects of smoking on survival and morbidity?. ### Response: Coronary Artery Surgery Study.


Instruction: What is the effect of smoking on survival of patients with angiographically documented coronary artery disease?

Output: reduces mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of smoking on survival of patients with angiographically documented coronary artery disease?. ### Response: reduces mortality.


Instruction: When was the JAMA 255:1023–7.647?

Output: 1986

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the JAMA 255:1023–7.647?. ### Response: 1986.


Instruction: What is MRFIT?

Output: Multiple Risk Factor Intervention Trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is MRFIT?. ### Response: Multiple Risk Factor Intervention Trial.


Instruction: What is the name of the study that investigated cancer in the Multiple Risk Factor Intervention Trial?

Output: MRFIT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated cancer in the Multiple Risk Factor Intervention Trial?. ### Response: MRFIT.


Instruction: How long did the study last?

Output: 15–year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the study last?. ### Response: 15–year.


Instruction: How many life-years gained from smoking cessation after coronary artery bypass surgery?

Output: Three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many life-years gained from smoking cessation after coronary artery bypass surgery?. ### Response: Three.


Instruction: How long was the follow-up study on smoking and cardiacevents after venous coronary bypass surgery conducted?

Output: 15–year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the follow-up study on smoking and cardiacevents after venous coronary bypass surgery conducted?. ### Response: 15–year.


Instruction: What year did Circulation. 1996:93:42-7.651?

Output: 1996

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Circulation. 1996:93:42-7.651?. ### Response: 1996.


Instruction: How long was the follow-up study of bypass surgery?

Output: 15–year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long was the follow-up study of bypass surgery?. ### Response: 15–year.


Instruction: What is the effect of smoking after coronary artery bypass surgery on endothelium-dependentvasodilation?

Output: reduces

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of smoking after coronary artery bypass surgery on endothelium-dependentvasodilation?. ### Response: reduces.


Instruction: What is a risk factor for sudden cardiac death in patients with coronaryartery disease?

Output: Current smoking

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk factor for sudden cardiac death in patients with coronaryartery disease?. ### Response: Current smoking.


Instruction: What is the name of the journal that published a study on smoking and coronary artery bypass grafts?

Output: Jpn Heart J.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that published a study on smoking and coronary artery bypass grafts?. ### Response: Jpn Heart J..


Instruction: When was the CMAJ 136:45–7.653?

Output: 1987

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the CMAJ 136:45–7.653?. ### Response: 1987.


Instruction: What is the effect of smoking on short-term outcome of patients undergoing coronary artery bypasssurgery?

Output: mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of smoking on short-term outcome of patients undergoing coronary artery bypasssurgery?. ### Response: mortality.


Instruction: What was the 2008 issue of Ann Thorac Surg.86:517–23.655?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the 2008 issue of Ann Thorac Surg.86:517–23.655?. ### Response: 2008.


Instruction: What are the risk factors for deep and Superficial chest surgical-site infections after coronary arterybypass graft surgery?

Output: different

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the risk factors for deep and Superficial chest surgical-site infections after coronary arterybypass graft surgery?. ### Response: different.


Instruction: What is the risk factor for deepand Superficial Chest surgical site infections?

Output: different

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk factor for deepand Superficial Chest surgical site infections?. ### Response: different.


Instruction: When did the J Thorac Cardiovasc Surg. 2002 issue 124?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the J Thorac Cardiovasc Surg. 2002 issue 124?. ### Response: 2002.


Instruction: What is smoking cessation in patients admitted for acute coronary heart disease?

Output: Predictors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is smoking cessation in patients admitted for acute coronary heart disease?. ### Response: Predictors.


Instruction: What is the name of the journal that deals with smoking ces-sation?

Output: Jpn Heart J.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that deals with smoking ces-sation?. ### Response: Jpn Heart J..


Instruction: When did Eur J Car-diovasc Prev Rehabil. 2005;12:472-7.658?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Eur J Car-diovasc Prev Rehabil. 2005;12:472-7.658?. ### Response: 2005.


Instruction: What can cause urticarial skin reac-tions?

Output: Heparin and LMWH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can cause urticarial skin reac-tions?. ### Response: Heparin and LMWH.


Instruction: What should be suspected in cases of skin necrosis at sites of injec-tion?

Output: HIT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be suspected in cases of skin necrosis at sites of injec-tion?. ### Response: HIT.


Instruction: How many different LMWH preparations did a patient develop skin reactions to?

Output: three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many different LMWH preparations did a patient develop skin reactions to?. ### Response: three.


Instruction: How many different LMWH preparations did people develop skin reactions to?

Output: three

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many different LMWH preparations did people develop skin reactions to?. ### Response: three.


Instruction: What has been limited to to date studies on the effects of fondaparinux on bone metabolism?

Output: in vitro exper-iments using cultured osteoblasts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been limited to to date studies on the effects of fondaparinux on bone metabolism?. ### Response: in vitro exper-iments using cultured osteoblasts.


Instruction: In one study, fondaparainux was compared with heparin, dalteparin or what?

Output: enoxaparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In one study, fondaparainux was compared with heparin, dalteparin or what?. ### Response: enoxaparin.


Instruction: What did fondaparinux show higher mitochondrial activity and protein synthesis than?

Output: unexposed osteoblasts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did fondaparinux show higher mitochondrial activity and protein synthesis than?. ### Response: unexposed osteoblasts.


Instruction: What did therapeutically relevant concentrations of heparin, dalteparin or enoxaparain decrease?

Output: matrix collagen type 2 content and calcification

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did therapeutically relevant concentrations of heparin, dalteparin or enoxaparain decrease?. ### Response: matrix collagen type 2 content and calcification.


Instruction: What did fonda-parinux have no effect on?

Output: osteo-blastic activity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did fonda-parinux have no effect on?. ### Response: osteo-blastic activity.


Instruction: What did a second study compare the effects of fondaparinx and dalteparin on human osteoblasts in culture?

Output: inhibited osteoblast prolifera-tion, protein synthesis, and the decreased levels of osteocalcin and alkaline phosphatase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did a second study compare the effects of fondaparinx and dalteparin on human osteoblasts in culture?. ### Response: inhibited osteoblast prolifera-tion, protein synthesis, and the decreased levels of osteocalcin and alkaline phosphatase.


Instruction: Dalteparain inhibited osteoblast prolifera-tion, protein synthesis, and the decreased levels of what?

Output: osteocalcin and alkaline phosphatase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Dalteparain inhibited osteoblast prolifera-tion, protein synthesis, and the decreased levels of what?. ### Response: osteocalcin and alkaline phosphatase.


Instruction: What did fondaparinux have no effect on?

Output: osteo-blastic activity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did fondaparinux have no effect on?. ### Response: osteo-blastic activity.


Instruction: What is not widely used in pregnancy because of insuffi cient safety data?

Output: fondaparinux

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not widely used in pregnancy because of insuffi cient safety data?. ### Response: fondaparinux.


Instruction: How many low levels of anti-Xa activity were detected in the umbilical cord blood in newborns of mothers treated with fondaparinux?

Output: 212

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many low levels of anti-Xa activity were detected in the umbilical cord blood in newborns of mothers treated with fondaparinux?. ### Response: 212.


Instruction: What is danaparoid Sodium a mixture of?

Output: glycosaminoglycans

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is danaparoid Sodium a mixture of?. ### Response: glycosaminoglycans.


Instruction: What does danaparoid act as?

Output: anticoagulant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does danaparoid act as?. ### Response: anticoagulant.


Instruction: What is the role of heparan sulfate in anticoagulation?

Output: decreased matrix collagen type 2 content and calcification

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of heparan sulfate in anticoagulation?. ### Response: decreased matrix collagen type 2 content and calcification.


Instruction: How long does half-life of danapraroid last?

Output: 25 h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does half-life of danapraroid last?. ### Response: 25 h.


Instruction: What is the half-life of danaparoid?

Output: 25

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the half-life of danaparoid?. ### Response: 25.


Instruction: What was shown to be effective for the prevention of venous thrombosis in high-risk patients?

Output: fondaparinux

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was shown to be effective for the prevention of venous thrombosis in high-risk patients?. ### Response: fondaparinux.


Instruction: What is the only agent that has been evaluated for HIT in a randomized clinical trial?

Output: Danaparoid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the only agent that has been evaluated for HIT in a randomized clinical trial?. ### Response: Danaparoid.


Instruction: What was reported to be signifi cantly better than dextran?

Output: Danaparoid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was reported to be signifi cantly better than dextran?. ### Response: Danaparoid.


Instruction: High success rates in the treatment of HIT have also been observed in what studies?

Output: retrospective studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: High success rates in the treatment of HIT have also been observed in what studies?. ### Response: retrospective studies.


Instruction: Danaparoid is approved for what in some countries?

Output: the treatment of HIT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Danaparoid is approved for what in some countries?. ### Response: the treatment of HIT.


Instruction: What country does Danaparoid not prolong the INR?

Output: United States

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What country does Danaparoid not prolong the INR?. ### Response: United States.


Instruction: What is the compound most bound to?

Output: AT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the compound most bound to?. ### Response: AT.


Instruction: How long does the compound last after it is almost complete bioavailability?

Output: 25 h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does the compound last after it is almost complete bioavailability?. ### Response: 25 h.


Instruction: What is a risk-enhancing factor for ASCVD?

Output: CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk-enhancing factor for ASCVD?. ### Response: CKD.


Instruction: What favors initiation of statin therapy in intermediate-risk patients?

Output: CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What favors initiation of statin therapy in intermediate-risk patients?. ### Response: CKD.


Instruction: In adults with CKD that requires dialysis treatment, initiation of a statin is not recommended on the basis of how many large-scale RCTs?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In adults with CKD that requires dialysis treatment, initiation of a statin is not recommended on the basis of how many large-scale RCTs?. ### Response: 2.


Instruction: Reduced eGFR (60 mL/min/1.73 m2 not on dialy-sis) and presence of albuminuria are what?

Output: independently associated with elevated risk of ASCVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Reduced eGFR (60 mL/min/1.73 m2 not on dialy-sis) and presence of albuminuria are what?. ### Response: independently associated with elevated risk of ASCVD.


Instruction: What is the ratio of albumin-to-creatinine ratio 30 mcg/mg?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ratio of albumin-to-creatinine ratio 30 mcg/mg?. ### Response: ≥.


Instruction: What does CKD count as in intermediate-risk patients?

Output: a risk-enhancing factor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CKD count as in intermediate-risk patients?. ### Response: a risk-enhancing factor.


Instruction: What increases the risk of CVD in patients with diabetes mellitus and no CKD?

Output: Presence of albuminuria with reduced eGFR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What increases the risk of CVD in patients with diabetes mellitus and no CKD?. ### Response: Presence of albuminuria with reduced eGFR.


Instruction: What is the risk graded and increases with severity of eGFR impairment?

Output: observed threshold of risk beginning around 75 mL/min/1.73 m2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk graded and increases with severity of eGFR impairment?. ### Response: observed threshold of risk beginning around 75 mL/min/1.73 m2.


Instruction: The observed threshold of risk begins around what?

Output: 75 mL/min/1.73 m2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The observed threshold of risk begins around what?. ### Response: 75 mL/min/1.73 m2.


Instruction: What is the risk associated with albuminuria linear?

Output: 75 mL/min/1.73 m2, whereas the risk associated with albuminuria is linear

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk associated with albuminuria linear?. ### Response: 75 mL/min/1.73 m2, whereas the risk associated with albuminuria is linear.


Instruction: What does statin use show?

Output: abso-lute benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does statin use show?. ### Response: abso-lute benefit.


Instruction: The benefit of statin is consistent across what stages of CKD?

Output: eGFR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The benefit of statin is consistent across what stages of CKD?. ### Response: eGFR.


Instruction: What is independently associated with CVD risk?

Output: Albuminuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is independently associated with CVD risk?. ### Response: Albuminuria.


Instruction: What was the one trial done for primary prevention in persons with albu-minuria and preserved eGFR?

Output: S4.5.4-72

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the one trial done for primary prevention in persons with albu-minuria and preserved eGFR?. ### Response: S4.5.4-72.


Instruction: What is the name of the SHARP trial?

Output: Study of Heart and Renal Protection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the SHARP trial?. ### Response: Study of Heart and Renal Protection.


Instruction: What percentage of people transitioned to dialysis?

Output: >30%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of people transitioned to dialysis?. ### Response: >30%.


Instruction: What was performed to reduce LDL-C?

Output: weighting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was performed to reduce LDL-C?. ### Response: weighting.


Instruction: What was similar in patients on dialysis and those who were not?

Output: the pro-portional effects on major atherosclerotic events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was similar in patients on dialysis and those who were not?. ### Response: the pro-portional effects on major atherosclerotic events.


Instruction: Who has the highest absolute risk of events?

Output: persons on dialysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who has the highest absolute risk of events?. ### Response: persons on dialysis.


Instruction: How many deaths are thought to be due to atherosclerotic events?

Output: lower

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many deaths are thought to be due to atherosclerotic events?. ### Response: lower.


Instruction: The lack of benefit in RCTs with statin initiation among persons on dialysis raises the question of what?

Output: competing risks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The lack of benefit in RCTs with statin initiation among persons on dialysis raises the question of what?. ### Response: competing risks.


Instruction: What is the acronym for Society of Hypertension?

Output: ESH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for Society of Hypertension?. ### Response: ESH.


Instruction: What does ESC stand for?

Output: European Society of Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ESC stand for?. ### Response: European Society of Cardiology.


Instruction: When did Eur Heart J.34:2159–219.5.4.2.

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Eur Heart J.34:2159–219.5.4.2.. ### Response: 2013.


Instruction: What is used as a screening test for primary aldosteronism?

Output: plasma aldosterone concentra-tion-to-plasma renin activity ratio

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used as a screening test for primary aldosteronism?. ### Response: plasma aldosterone concentra-tion-to-plasma renin activity ratio.


Instruction: What did Funder JW, Carey RM, Fardella C, et al. Do patients with primary aldosteronism have a clinical practice guideline?

Output: Case detection, diagnosis, and treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Funder JW, Carey RM, Fardella C, et al. Do patients with primary aldosteronism have a clinical practice guideline?. ### Response: Case detection, diagnosis, and treatment.


Instruction: What was the name of the systematic review of the literature?

Output: population-based studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the systematic review of the literature?. ### Response: population-based studies.


Instruction: What is the management of pri-mary aldosteronism: case detection, diagnosis, and treatment: an Endocrine Society clinical practice guideline?

Output: Effectiveness of eplere-none or spironolactone treatment in preserving renal function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the management of pri-mary aldosteronism: case detection, diagnosis, and treatment: an Endocrine Society clinical practice guideline?. ### Response: Effectiveness of eplere-none or spironolactone treatment in preserving renal function.


Instruction: When did the J Clin Endocrinol Metab. 2016:101:1889–916?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the J Clin Endocrinol Metab. 2016:101:1889–916?. ### Response: 2004.


Instruction: How many continents are there in the study of primary aldosteronism?

Output: five

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many continents are there in the study of primary aldosteronism?. ### Response: five.


Instruction: What is the J Clin Endocrinol Metab. 2004:89:1045-50?

Output: Increased diagno-sis of primary aldosteronism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the J Clin Endocrinol Metab. 2004:89:1045-50?. ### Response: Increased diagno-sis of primary aldosteronism.


Instruction: How is the prevalence of primary alopethyroidism compared to population-based studies?

Output: Prevalence of primary aldosteron-ism in patient's cohorts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the prevalence of primary alopethyroidism compared to population-based studies?. ### Response: Prevalence of primary aldosteron-ism in patient's cohorts.


Instruction: What study did Rossi GP, Bernini G and Desideri G conduct?

Output: PAPY Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What study did Rossi GP, Bernini G and Desideri G conduct?. ### Response: PAPY Study.


Instruction: What was the result of the PAPY Study?

Output: Renal damage in pri-mary aldosteronism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the result of the PAPY Study?. ### Response: Renal damage in pri-mary aldosteronism.


Instruction: What type of aldosteronism is associated with long-term cardio- and cerebrovascular events in patients?

Output: primary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of aldosteronism is associated with long-term cardio- and cerebrovascular events in patients?. ### Response: primary.


Instruction: What is the J Clin Endocrinol Metab 2013;98:4826-33?

Output: Long-term cardio- and cerebrovascular events in patients with primary aldosteronism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the J Clin Endocrinol Metab 2013;98:4826-33?. ### Response: Long-term cardio- and cerebrovascular events in patients with primary aldosteronism.


Instruction: What is eplere-none or spironolactone effective in preserving in primary aldosteronism?

Output: renal function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is eplere-none or spironolactone effective in preserving in primary aldosteronism?. ### Response: renal function.


Instruction: What is Rossi GP, Cesari M, Cuspidi C?

Output: Long-term control of arterial hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Rossi GP, Cesari M, Cuspidi C?. ### Response: Long-term control of arterial hypertension.


Instruction: What is spironolactone used for in primary aldosteronism?

Output: preserving renal function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is spironolactone used for in primary aldosteronism?. ### Response: preserving renal function.


Instruction: What is Renal Artery Stenosis S5.4.3-1?

Output: Stenting and medical therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Renal Artery Stenosis S5.4.3-1?. ### Response: Stenting and medical therapy.


Instruction: How does Stenting and medical therapy treat atherosclerotic renal-artery stenosis?

Output: revasculariza-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does Stenting and medical therapy treat atherosclerotic renal-artery stenosis?. ### Response: revasculariza-tion.


Instruction: What is the name of the meta-analysis of revasculariza-tion versus medical therapy for atherosclerotic renal artery stenosis?

Output: Riaz IB

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis of revasculariza-tion versus medical therapy for atherosclerotic renal artery stenosis?. ### Response: Riaz IB.


Instruction: What are the names of the first 447 patients in the United States Registry for Fibromuscular Dysplasia?

Output: Olin JW, Froehlich J, Gu X

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the first 447 patients in the United States Registry for Fibromuscular Dysplasia?. ### Response: Olin JW, Froehlich J, Gu X.


Instruction: How many patients were treated with renovascular reconstruction in the first 447 patients?

Output: 916

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with renovascular reconstruction in the first 447 patients?. ### Response: 916.


Instruction: What is the name of the study that evaluated the revascularization of the heart?

Output: PAPY Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated the revascularization of the heart?. ### Response: PAPY Study.


Instruction: Who is the author of a study that examined the long-term and short-term outcomes of renoplasty?

Output: Lamawansa MD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of a study that examined the long-term and short-term outcomes of renoplasty?. ### Response: Lamawansa MD.


Instruction: What is the effect of home testing ofinternational normalized ratio on clinical events?

Output: 89

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of home testing ofinternational normalized ratio on clinical events?. ### Response: 89.


Instruction: What is a systematic review and metaregression of study setting on anticoagulation control?

Output: Effect of study setting on anticoagulation control: a systematicreview and metaregression. Chest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a systematic review and metaregression of study setting on anticoagulation control?. ### Response: Effect of study setting on anticoagulation control: a systematicreview and metaregression. Chest.


Instruction: What is the name of the systematic review and metaregression?

Output: Chest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and metaregression?. ### Response: Chest.


Instruction: What are the names of the authors of the metareview?

Output: van Walraven C, Jennings A, Oake N, Fergusson D, Forster AJ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the authors of the metareview?. ### Response: van Walraven C, Jennings A, Oake N, Fergusson D, Forster AJ.


Instruction: How is self-monitoring done?

Output: self-management of oral anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is self-monitoring done?. ### Response: self-management of oral anticoagulation.


Instruction: What is the European Society of Cardiology Working Group onThrombosis known as?

Output: European Heart Rhythm Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the European Society of Cardiology Working Group onThrombosis known as?. ### Response: European Heart Rhythm Association.


Instruction: What is EAPCI?

Output: European Association of Percutaneous CardiovascularInterventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is EAPCI?. ### Response: European Association of Percutaneous CardiovascularInterventions.


Instruction: Who endorsed the joint consensus document?

Output: Heart Rhythm Society(HRS) and Asia-Paci ﬁc Heart Rhythm Society (APHRS).

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who endorsed the joint consensus document?. ### Response: Heart Rhythm Society(HRS) and Asia-Paci ﬁc Heart Rhythm Society (APHRS)..


Instruction: The Heart Rhythm Society and Asia-Paci fic endorsed a joint document on what?

Output: AcuteCardiac Care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The Heart Rhythm Society and Asia-Paci fic endorsed a joint document on what?. ### Response: AcuteCardiac Care.


Instruction: What is the acronym for the Association of Cardiovascular Associations?

Output: AcuteCardiac Care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the Association of Cardiovascular Associations?. ### Response: AcuteCardiac Care.


Instruction: Who endorses the ACCA?

Output: Heart Rhythm Society(HRS) and Asia-Paci ﬁc Heart Rhythm Society

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who endorses the ACCA?. ### Response: Heart Rhythm Society(HRS) and Asia-Paci ﬁc Heart Rhythm Society.


Instruction: What does APHRS stand for?

Output: Asia-Paci ﬁc Heart Rhythm Society

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does APHRS stand for?. ### Response: Asia-Paci ﬁc Heart Rhythm Society.


Instruction: When was the EurHeart J 2014 published?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the EurHeart J 2014 published?. ### Response: 2014.


Instruction: Who is Spyropoulos AC, Kaatz S, et al. Perioperative bridginganticoagulation in patients with atrial fibrillation?

Output: Douketis JD, Hasselblad V, Ortel TL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is Spyropoulos AC, Kaatz S, et al. Perioperative bridginganticoagulation in patients with atrial fibrillation?. ### Response: Douketis JD, Hasselblad V, Ortel TL.


Instruction: Man-Son-Hing M, Nichol G, Lau A, Laupacis A. Choosingantithrombotic therapy for elderly patients who are at risk for falls?

Output: Arch Intern Med . 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Man-Son-Hing M, Nichol G, Lau A, Laupacis A. Choosingantithrombotic therapy for elderly patients who are at risk for falls?. ### Response: Arch Intern Med . 1999.


Instruction: What is the name of the study that investigated bleeding in patients with atrial fibrillation and liver fibrosis ontreatment with vitamin K or non-vitamin K antagonist oralanticoagulants?

Output: Euro HeartSurvey

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated bleeding in patients with atrial fibrillation and liver fibrosis ontreatment with vitamin K or non-vitamin K antagonist oralanticoagulants?. ### Response: Euro HeartSurvey.


Instruction: What year did Intern Med publish a 159(7):677-685?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Intern Med publish a 159(7):677-685?. ### Response: 1999.


Instruction: What does HAS-BLED stand for?

Output: user-friendly score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does HAS-BLED stand for?. ### Response: user-friendly score.


Instruction: What is the name of a novel user-friendly score to assess 1-year risk of?

Output: HAS-BLED

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of a novel user-friendly score to assess 1-year risk of?. ### Response: HAS-BLED.


Instruction: What is the GY.A novel user-friendly score?

Output: HAS-BLED

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the GY.A novel user-friendly score?. ### Response: HAS-BLED.


Instruction: What does the Euro HeartSurvey assess in patients with atrial fibrillation?

Output: 1-year risk ofmajor bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Euro HeartSurvey assess in patients with atrial fibrillation?. ### Response: 1-year risk ofmajor bleeding.


Instruction: What is the acronym for atrial fibrillation?

Output: National Registry ofAtrial Fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for atrial fibrillation?. ### Response: National Registry ofAtrial Fibrillation.


Instruction: What does NRAF stand for?

Output: National Registry ofAtrial Fibrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does NRAF stand for?. ### Response: National Registry ofAtrial Fibrillation.


Instruction: When was the Am Heart J 151(3):713-719.100?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Am Heart J 151(3):713-719.100?. ### Response: 2006.


Instruction: How is the ORBIT bleedingscore calculated?

Output: simple bedside score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the ORBIT bleedingscore calculated?. ### Response: simple bedside score.


Instruction: What is a simple bedside score to assess bleeding risk in atrialfibrillation?

Output: ORBIT bleedingscore

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a simple bedside score to assess bleeding risk in atrialfibrillation?. ### Response: ORBIT bleedingscore.


Instruction: What is the ORBIT bleedingscore?

Output: a simple bedside score to assess bleeding risk in atrialﬁbrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ORBIT bleedingscore?. ### Response: a simple bedside score to assess bleeding risk in atrialﬁbrillation.


Instruction: What was the mortality rate of patients with PCI at 3 years of follow-up?

Output: 6.2%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mortality rate of patients with PCI at 3 years of follow-up?. ### Response: 6.2%.


Instruction: How was mortality rate in patients treated with CABG?

Output: 2.9%).

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was mortality rate in patients treated with CABG?. ### Response: 2.9%)..


Instruction: When was the data on mortality from PCI published?

Output: April 26, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the data on mortality from PCI published?. ### Response: April 26, 2023.


Instruction: What did the EPILOG Investigators platelet glycoprotein IIb/IIIa receptorblockade and low-dose heparin do during percutaneous coronary revascu-larization?

Output: inhibition

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the EPILOG Investigators platelet glycoprotein IIb/IIIa receptorblockade and low-dose heparin do during percutaneous coronary revascu-larization?. ### Response: inhibition.


Instruction: What did Boersma E, Akkerhuis KM, Theroux P, et al. do during medical treatment?

Output: early benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Boersma E, Akkerhuis KM, Theroux P, et al. do during medical treatment?. ### Response: early benefit.


Instruction: What is the only option for medical treatment?

Output: Platelet glycoproteinIIb/IIIa receptor inhibition

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the only option for medical treatment?. ### Response: Platelet glycoproteinIIb/IIIa receptor inhibition.


Instruction: What is additionalprotection during percutaneous coronary intervention?

Output: oftirofiban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is additionalprotection during percutaneous coronary intervention?. ### Response: oftirofiban.


Instruction: How does abciximab compare to serum troponin Tlevels?

Output: Benefit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does abciximab compare to serum troponin Tlevels?. ### Response: Benefit.


Instruction: What is the name of the study investigators that investigated angina?

Output: EPISTENT Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study investigators that investigated angina?. ### Response: EPISTENT Investigators.


Instruction: When was the N Engl J Med 340:1623–9.616?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the N Engl J Med 340:1623–9.616?. ### Response: 1999.


Instruction: What is Abciximab used for in patients with coronary syndromes?

Output: restenosis reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Abciximab used for in patients with coronary syndromes?. ### Response: restenosis reduction.


Instruction: What reduces mortality in diabetic patients with non-ST-segment-elevation acute coronary syndromes?

Output: Platelet glycoprotein IIb/IIIainhibitors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What reduces mortality in diabetic patients with non-ST-segment-elevation acute coronary syndromes?. ### Response: Platelet glycoprotein IIb/IIIainhibitors.


Instruction: What does platelet glycoprotein IIb/IIIainhibitors reduce?

Output: mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does platelet glycoprotein IIb/IIIainhibitors reduce?. ### Response: mortality.


Instruction: When did Circulation. 2001;104:2767–71.618.

Output: 2001

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circulation. 2001;104:2767–71.618.. ### Response: 2001.


Instruction: What is used in high-risk coronary angio-plasty?

Output: monoclonal antibody

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used in high-risk coronary angio-plasty?. ### Response: monoclonal antibody.


Instruction: What is the additive value of oftirofiban administered with the high-dose bolus in the prevention of ischemic complications during high-risk coronary angioplasty?

Output: theADVANCE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the additive value of oftirofiban administered with the high-dose bolus in the prevention of ischemic complications during high-risk coronary angioplasty?. ### Response: theADVANCE.


Instruction: When was theADVANCE Trial conducted?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was theADVANCE Trial conducted?. ### Response: 2004.


Instruction: What was the name of the randomised placebo-controlled and balloon-Angioplasty-controlled trial?

Output: EPISTENT Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the name of the randomised placebo-controlled and balloon-Angioplasty-controlled trial?. ### Response: EPISTENT Investigators.


Instruction: What is the purpose of the placebo-controlled trial?

Output: restenosis reduction in small coronaryarteries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the purpose of the placebo-controlled trial?. ### Response: restenosis reduction in small coronaryarteries.


Instruction: What is used to assess the safety of coronary stenting with use of platelet glycoprotein-IIb/IIIa blockade?

Output: Randomised placebo-controlled and balloon-angioplasty-controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used to assess the safety of coronary stenting with use of platelet glycoprotein-IIb/IIIa blockade?. ### Response: Randomised placebo-controlled and balloon-angioplasty-controlled trial.


Instruction: When did Lancet issue a correction for ESPRIT?

Output: 2001

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Lancet issue a correction for ESPRIT?. ### Response: 2001.


Instruction: What is abciximab inelective percutaneous coronary intervention after pretreatment with clopidogrel?

Output: clinical trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is abciximab inelective percutaneous coronary intervention after pretreatment with clopidogrel?. ### Response: clinical trial.


Instruction: What is a randomized clinical trial ofabcixib in diabetic patients undergoing electivepercutaneouscoronary interventions after treatment with high loading?

Output: ISAR-REACT 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a randomized clinical trial ofabcixib in diabetic patients undergoing electivepercutaneouscoronary interventions after treatment with high loading?. ### Response: ISAR-REACT 2.


Instruction: What drug was used after a high loading dose of clopidogrel?

Output: abciximab

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug was used after a high loading dose of clopidogrel?. ### Response: abciximab.


Instruction: What is the name of the randomized trial that compared phosphorylcholine-coated stenting with balloon angioplasty andabciximab?

Output: ISAR-REACT 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized trial that compared phosphorylcholine-coated stenting with balloon angioplasty andabciximab?. ### Response: ISAR-REACT 2.


Instruction: What is the name of the drug used to treat coronary arteries?

Output: oftirofiban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used to treat coronary arteries?. ### Response: oftirofiban.


Instruction: When was the J Intern Med 256:388–97.625?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Intern Med 256:388–97.625?. ### Response: 2004.


Instruction: What is a bivalirudin compared to?

Output: additive value

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a bivalirudin compared to?. ### Response: additive value.


Instruction: What can be successfully performed in chil-dren of all ages?

Output: Catheter ablation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be successfully performed in chil-dren of all ages?. ### Response: Catheter ablation.


Instruction: What are influenced by the presence of structural heart disease or ischemic heart dis-ease?

Output: Success rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are influenced by the presence of structural heart disease or ischemic heart dis-ease?. ### Response: Success rates.


Instruction: What are the highest rates of heart disease in left-sided accessory pathways?

Output: Success rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the highest rates of heart disease in left-sided accessory pathways?. ### Response: Success rates.


Instruction: Complications were reported in 4% to 8% of the initial large series, with major complications in 0.9% to 3.2%?

Output: complication rates were higher in patients weighing <15 kg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Complications were reported in 4% to 8% of the initial large series, with major complications in 0.9% to 3.2%?. ### Response: complication rates were higher in patients weighing <15 kg.


Instruction: What was the complication rate higher in patients weighing 15 kg?

Output: <15 kg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the complication rate higher in patients weighing 15 kg?. ### Response: <15 kg.


Instruction: How much weight was reported in children with normal hearts in early series?

Output: 0.12%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much weight was reported in children with normal hearts in early series?. ### Response: 0.12%.


Instruction: What was associated with lower weight and increased number of heartbeats?

Output: death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with lower weight and increased number of heartbeats?. ### Response: death.


Instruction: How much of a child with normal heart was reported to have died?

Output: 0.12%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of a child with normal heart was reported to have died?. ### Response: 0.12%.


Instruction: What was associated with lower weight and increased number of ablation lesions?

Output: death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with lower weight and increased number of ablation lesions?. ### Response: death.


Instruction: What have reduced the incidence of complications and radiation exposure associated with the procedure?

Output: Increased institu-tional experience, advanced mapping techniques, and use of cryoablation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have reduced the incidence of complications and radiation exposure associated with the procedure?. ### Response: Increased institu-tional experience, advanced mapping techniques, and use of cryoablation.


Instruction: Most centers perform elective ablation for children weighing >12 kg?

Output: 15 kg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Most centers perform elective ablation for children weighing >12 kg?. ### Response: 15 kg.


Instruction: What does most centers perform for children weighing >12 kg to 15 kg?

Output: elective ablation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does most centers perform for children weighing >12 kg to 15 kg?. ### Response: elective ablation.


Instruction: What is generally reserved for those with medically refractory Figure 17?

Output: ablation in younger or smaller chil-dren

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is generally reserved for those with medically refractory Figure 17?. ### Response: ablation in younger or smaller chil-dren.


Instruction: What morphologies are shown for common types of atrial flutter?

Output: P-wave

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What morphologies are shown for common types of atrial flutter?. ### Response: P-wave.


Instruction: What is not always a reliable guide to the re-entry circuit location?

Output: P-wave morphology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not always a reliable guide to the re-entry circuit location?. ### Response: P-wave morphology.


Instruction: What does bpm indicate?

Output: beats per minute

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does bpm indicate?. ### Response: beats per minute.


Instruction: What does ECG stand for?

Output: electrocardiogram

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ECG stand for?. ### Response: electrocardiogram.


Instruction: When was this article originally published?

Output: April 23, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this article originally published?. ### Response: April 23, 2023.


Instruction: ACC/AHA Task Force on Performance Measures: Attributes for what measure?

Output: Performance Measures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ACC/AHA Task Force on Performance Measures: Attributes for what measure?. ### Response: Performance Measures.


Instruction: Evidence Based High-impact area that is useful in improving patient outcomesa.

Output: Exceptions and exclusions are supported by evidence. Reliability

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Evidence Based High-impact area that is useful in improving patient outcomesa.. ### Response: Exceptions and exclusions are supported by evidence. Reliability.


Instruction: For structural measures, the structure should be closely linked to what?

Output: a meaningful process of care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For structural measures, the structure should be closely linked to what?. ### Response: a meaningful process of care.


Instruction: What should the scientific basis for a process measure be well established?

Output: the process should be closely linked to a meaningful patient outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should the scientific basis for a process measure be well established?. ### Response: the process should be closely linked to a meaningful patient outcome.


Instruction: What should be closely linked to a meaningful patient outcome?

Output: process measures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be closely linked to a meaningful patient outcome?. ### Response: process measures.


Instruction: The outcome should be what?

Output: clinically meaningful

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The outcome should be what?. ### Response: clinically meaningful.


Instruction: What should be clinically meaningful?

Output: outcome measures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be clinically meaningful?. ### Response: outcome measures.


Instruction: What should performance measures based on outcomes adjust for relevant clinical characteristics through the use of?

Output: appropriate methodology and high-quality data sources

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should performance measures based on outcomes adjust for relevant clinical characteristics through the use of?. ### Response: appropriate methodology and high-quality data sources.


Instruction: What is a denominator?

Output: patient group to whom the measure applies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a denominator?. ### Response: patient group to whom the measure applies.


Instruction: What does a numberator do?

Output: conformance is achieved

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does a numberator do?. ### Response: conformance is achieved.


Instruction: How are exceptions and exclusions supported?

Output: by evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are exceptions and exclusions supported?. ### Response: by evidence.


Instruction: What does the measure appear to assess?

Output: what it is intended to

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the measure appear to assess?. ### Response: what it is intended to.


Instruction: What captures most meaningful aspects of care?

Output: Content validity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What captures most meaningful aspects of care?. ### Response: Content validity.


Instruction: Does the measure correlate well with other measures?

Output: The measure correlates well with other measures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Does the measure correlate well with other measures?. ### Response: The measure correlates well with other measures.


Instruction: What can be obtained with reasonable effort and cost?

Output: The data required for the measure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be obtained with reasonable effort and cost?. ### Response: The data required for the measure.


Instruction: How can the data required for the measure be obtained within the period allowed for data collection?

Output: Reasonable time period b

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How can the data required for the measure be obtained within the period allowed for data collection?. ### Response: Reasonable time period b.


Instruction: Who is held accountable for the actions taken?

Output: American Heart Association, Inc., and American College of Cardiology Foundation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is held accountable for the actions taken?. ### Response: American Heart Association, Inc., and American College of Cardiology Foundation.


Instruction: What is the likelihood of negative unintended consequences with a measure?

Output: low

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the likelihood of negative unintended consequences with a measure?. ### Response: low.


Instruction: Who is responsible for the care process or outcome?

Output: Those held accountable

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is responsible for the care process or outcome?. ### Response: Those held accountable.


Instruction: What is the acronym for American Heart Association, Inc.?

Output: AHA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for American Heart Association, Inc.?. ### Response: AHA.


Instruction: What does AHA stand for?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does AHA stand for?. ### Response: American Heart Association.


Instruction: When did the AHA Journals become available?

Output: May 3, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the AHA Journals become available?. ### Response: May 3, 2023.


Instruction: What is an acceptable alternative to CDT in all patients withcute DVT who do not have impending venousgangrene16?

Output: anticoagulant therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an acceptable alternative to CDT in all patients withcute DVT who do not have impending venousgangrene16?. ### Response: anticoagulant therapy.


Instruction: What do we suggest in patients with acute proximal DVT of the leg?

Output: anticoagulant therapy alone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do we suggest in patients with acute proximal DVT of the leg?. ### Response: anticoagulant therapy alone.


Instruction: What are patients who are most likely to benefit from CDT?

Output: who attach a high value to prevention ofPTS, and a lower value to the initial complexity, cost,and risk of bleeding with CDT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients who are most likely to benefit from CDT?. ### Response: who attach a high value to prevention ofPTS, and a lower value to the initial complexity, cost,and risk of bleeding with CDT.


Instruction: Patients who attach a high value to prevention ofPTS and a lower value to the initial complexity, cost, and risk of bleeding with CDT are likely to choose CDT over what?

Output: anticoagulation alone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients who attach a high value to prevention ofPTS and a lower value to the initial complexity, cost, and risk of bleeding with CDT are likely to choose CDT over what?. ### Response: anticoagulation alone.


Instruction: What is the role of IVC Filter in Addition to Anticoagulation for Acute DVT?

Output: PESummary of the Evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the role of IVC Filter in Addition to Anticoagulation for Acute DVT?. ### Response: PESummary of the Evidence.


Instruction: What did the PREPIC randomizedtrial show?

Output: increased DVT, decreased PE, and did notinﬂuence VTE (DVT and PE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the PREPIC randomizedtrial show?. ### Response: increased DVT, decreased PE, and did notinﬂuence VTE (DVT and PE.


Instruction: What did placement of a permanent IVCfilter increase or decrease?

Output: increased DVT, decreased PE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did placement of a permanent IVCfilter increase or decrease?. ### Response: increased DVT, decreased PE.


Instruction: What did DVT, decreased PE, and did not influence VTE or mortality?

Output: placement of a permanentIVCﬁlter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did DVT, decreased PE, and did not influence VTE or mortality?. ### Response: placement of a permanentIVCﬁlter.


Instruction: What have several registries suggested that IVC filters can reduce in acute VTE?

Output: early mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have several registries suggested that IVC filters can reduce in acute VTE?. ### Response: early mortality.


Instruction: How long did it take for an IVC filter to be removed?

Output: 3 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for an IVC filter to be removed?. ### Response: 3 months.


Instruction: What did the removal of the filter not reduce?

Output: recurrent PE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the removal of the filter not reduce?. ### Response: recurrent PE.