Instruction: What is required during index hospitalization because of ongoing ischemia or HF?

Output: surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is required during index hospitalization because of ongoing ischemia or HF?. ### Response: surgery.


Instruction: A downsized annu-loplasty ring usually is what?

Output: mitral valve repair

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A downsized annu-loplasty ring usually is what?. ### Response: mitral valve repair.


Instruction: What is usually performed with a downsized annu-loplasty ring?

Output: mitral valve repair

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is usually performed with a downsized annu-loplasty ring?. ### Response: mitral valve repair.


Instruction: What may be preferred in many cases?

Output: valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be preferred in many cases?. ### Response: valve replacement.


Instruction: How does management of ischemic mitral regurgitation differ?

Output: importantly

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does management of ischemic mitral regurgitation differ?. ### Response: importantly.


Instruction: What is usually heralded by a loud sys-tolic murmur and HF or shock depending on the size of the defect and the degree of RV and LV dysfunction?

Output: Ventricular Septal RuptureVentricular septal rupture

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is usually heralded by a loud sys-tolic murmur and HF or shock depending on the size of the defect and the degree of RV and LV dysfunction?. ### Response: Ventricular Septal RuptureVentricular septal rupture.


Instruction: What is GUSTO-1?

Output: The Global Use of Strategies to Open Occluded Coronary Arteries

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is GUSTO-1?. ### Response: The Global Use of Strategies to Open Occluded Coronary Arteries.


Instruction: What is the name of the trial?

Output: GUSTO-1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the trial?. ### Response: GUSTO-1.


Instruction: When was the SHOCK registry downloaded?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the SHOCK registry downloaded?. ### Response: April 28, 2023.


Instruction: On what date was the Coronary Arteries trial released?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On what date was the Coronary Arteries trial released?. ### Response: April 28, 2023.


Instruction: What should be used as a r eason not to off er anticoagulation?

Output: bleeding risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be used as a r eason not to off er anticoagulation?. ### Response: bleeding risk.


Instruction: What should typically be used for a pr ompt t?

Output: bleeding risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should typically be used for a pr ompt t?. ### Response: bleeding risk.


Instruction: What should be used to identify and manage modifiable risk f actors f or bleeding rather?

Output: age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be used to identify and manage modifiable risk f actors f or bleeding rather?. ### Response: age.


Instruction: What should typically be used as a pr ompt t o identify and m eason f offering anticoagulation in people at incr eased risk?

Output: Age

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should typically be used as a pr ompt t o identify and m eason f offering anticoagulation in people at incr eased risk?. ### Response: Age.


Instruction: When anticoagulation is not giv en because of bleeding risk, people should ha ve regular r eview and what else?

Output: r econsideration f or treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When anticoagulation is not giv en because of bleeding risk, people should ha ve regular r eview and what else?. ### Response: r econsideration f or treatment.


Instruction: The committ ee w ere concerned t hat what is sometimes not recommended f or people at risk?

Output: anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committ ee w ere concerned t hat what is sometimes not recommended f or people at risk?. ### Response: anticoagulation.


Instruction: What is not r ecommended for people at risk of f alls and f or older people?

Output: anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not r ecommended for people at risk of f alls and f or older people?. ### Response: anticoagulation.


Instruction: Age was t herefore added t o the bleeding risk scor e and what ar e rar ely a cause of major hemorrhage?

Output: f alls

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Age was t herefore added t o the bleeding risk scor e and what ar e rar ely a cause of major hemorrhage?. ### Response: f alls.


Instruction: When should anticoagulation be offered to people at risk of major haemorrhage?

Output: when needed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When should anticoagulation be offered to people at risk of major haemorrhage?. ### Response: when needed.


Instruction: What should be discussed with the person?

Output: The benefit s and harms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be discussed with the person?. ### Response: The benefit s and harms.


Instruction: What should be discussed wit h the person?

Output: The benefit s and harms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be discussed wit h the person?. ### Response: The benefit s and harms.


Instruction: What ar e likely to lead t o a change in current practice?

Output: r ecommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What ar e likely to lead t o a change in current practice?. ### Response: r ecommendations.


Instruction: What is the unit cost of a direct-acting anticoagulant compared to war farin?

Output: gr eater

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the unit cost of a direct-acting anticoagulant compared to war farin?. ### Response: gr eater.


Instruction: What is gr eater than t hat f or war farin?

Output: The unit cost of direct-acting anticoagulant s

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is gr eater than t hat f or war farin?. ### Response: The unit cost of direct-acting anticoagulant s.


Instruction: What is lik ely to be a resour ce impact fr om incr eased use of dir ect-acting anticoagulant?

Output: reduction in warfarin use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is lik ely to be a resour ce impact fr om incr eased use of dir ect-acting anticoagulant?. ### Response: reduction in warfarin use.


Instruction: What did the c ommi ttee make the recommendations based on?

Output: experience and kno wledge

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the c ommi ttee make the recommendations based on?. ### Response: experience and kno wledge.


Instruction: What was the use of beta-blockers or rat e-limiting calcium-channel block ers for?

Output: initial rat e-contr ol treatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the use of beta-blockers or rat e-limiting calcium-channel block ers for?. ### Response: initial rat e-contr ol treatment.


Instruction: What was used for initial rat e-control treatment?

Output: beta-block ers or rat e-limiting calcium-channel block ers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was used for initial rat e-control treatment?. ### Response: beta-block ers or rat e-limiting calcium-channel block ers.


Instruction: What was the title of Atrial fibrillation: diagnosis and management?

Output: NG196

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the title of Atrial fibrillation: diagnosis and management?. ### Response: NG196.


Instruction: What is the subject of Notice of right s?

Output: All right s reserved

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the subject of Notice of right s?. ### Response: All right s reserved.


Instruction: When was the last updat ed?

Output: 30 June 2021

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the last updat ed?. ### Response: 30 June 2021.


Instruction: What did spouses feel they would rather healthcare professionals make about deactivation so they didn't have to?

Output: decis ions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did spouses feel they would rather healthcare professionals make about deactivation so they didn't have to?. ### Response: decis ions.


Instruction: Why did healthcare professionals not have to make decisions about deactivation?

Output: staff or magnets were unavailable in community hospitals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why did healthcare professionals not have to make decisions about deactivation?. ### Response: staff or magnets were unavailable in community hospitals.


Instruction: Why did professionals report reasons they were unable to deactivate ICDs?

Output: deactivation was often not possible out of h ours, when staff or magnets were unavailable in community hospitals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why did professionals report reasons they were unable to deactivate ICDs?. ### Response: deactivation was often not possible out of h ours, when staff or magnets were unavailable in community hospitals.


Instruction: When were magnets or staff unavailable in community hospitals?

Output: unavailability of magnets or insufficient education on how to use magnets

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When were magnets or staff unavailable in community hospitals?. ### Response: unavailability of magnets or insufficient education on how to use magnets.


Instruction: What did some healthcare professionals find that consultants were unavailable to visit dying patients in the community to deactivate?

Output: ICDs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did some healthcare professionals find that consultants were unavailable to visit dying patients in the community to deactivate?. ### Response: ICDs.


Instruction: What was the cause of excessive time delays?

Output: lack of defined process in  the community

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the cause of excessive time delays?. ### Response: lack of defined process in  the community.


Instruction: What did some people complain about?

Output: excessive time delays

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did some people complain about?. ### Response: excessive time delays.


Instruction: How many phone calls did people have to make?

Output: lots

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many phone calls did people have to make?. ### Response: lots.


Instruction: How many phone calls did technicians have to make in order to access support for deactivation?

Output: lots

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many phone calls did technicians have to make in order to access support for deactivation?. ### Response: lots.


Instruction: What made the process of deactivating ICD long and difficult?

Output: there was no local or national policy or procedures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What made the process of deactivating ICD long and difficult?. ### Response: there was no local or national policy or procedures.


Instruction: What are some concerns about the coherence of the contributing studies with nothing to lower confidence?

Output: minor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some concerns about the coherence of the contributing studies with nothing to lower confidence?. ### Response: minor.


Instruction: What is a minor concern about the inadequacy of the evidence?

Output: the evidence provided reasonable depth

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a minor concern about the inadequacy of the evidence?. ### Response: the evidence provided reasonable depth.


Instruction: What was the overall judgement of the sub-finding?

Output: moderate  confidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the overall judgement of the sub-finding?. ### Response: moderate  confidence.


Instruction: What concerns were there about the evidence?

Output: there was no local or national policy or procedures related to ICD deactivation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What concerns were there about the evidence?. ### Response: there was no local or national policy or procedures related to ICD deactivation.


Instruction: Patients decide Healthcare professionals felt what?

Output: 'competent' ICD recipients  should decide whether to deactivate  their device

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients decide Healthcare professionals felt what?. ### Response: 'competent' ICD recipients  should decide whether to deactivate  their device.


Instruction: Who felt competent ICD recipients should decide whether to deactivate their device?

Output: Healthcare professionals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who felt competent ICD recipients should decide whether to deactivate their device?. ### Response: Healthcare professionals.


Instruction: What did Healthcare professionals highlight the importance of?

Output: discussions with the person  and family

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Healthcare professionals highlight the importance of?. ### Response: discussions with the person  and family.


Instruction: What should have an end of life discussion?

Output: iologists considering  implanting a device

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should have an end of life discussion?. ### Response: iologists considering  implanting a device.


Instruction: Patients reported that the frequency and pain of shocks, overall quality of life and recommendations of the physician could impact their decision?

Output: deactivation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients reported that the frequency and pain of shocks, overall quality of life and recommendations of the physician could impact their decision?. ### Response: deactivation.


Instruction: Nurses felt that families sometimes put pressure on patients to get a device or to what?

Output: keep a device active

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Nurses felt that families sometimes put pressure on patients to get a device or to what?. ### Response: keep a device active.


Instruction: What type of patients are put pressure on to get a device?

Output: families

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of patients are put pressure on to get a device?. ### Response: families.


Instruction: What are some concerns about the coherence of the studies contributing to this sub-finding?

Output: minor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some concerns about the coherence of the studies contributing to this sub-finding?. ### Response: minor.


Instruction: Why was there a lack of depth in the evidence?

Output: moderate  concerns about inadequacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was there a lack of depth in the evidence?. ### Response: moderate  concerns about inadequacy.


Instruction: What was the overall judgement of the study?

Output: moderate  confidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the overall judgement of the study?. ### Response: moderate  confidence.


Instruction: What is the overall judgement of low confidence in this sub-finding?

Output: very low  confidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the overall judgement of low confidence in this sub-finding?. ### Response: very low  confidence.


Instruction: What are concerns regarding methodological limitations, relevance and adequacy?

Output: very low  confidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are concerns regarding methodological limitations, relevance and adequacy?. ### Response: very low  confidence.


Instruction: What are the risk loci 9p21, 4q25, and 16q22?

Output: Although tests are commercially available

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the risk loci 9p21, 4q25, and 16q22?. ### Response: Although tests are commercially available.


Instruction: What have genome-wide association studies identified?

Output: novel genetic variants influencing risk of stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have genome-wide association studies identified?. ### Response: novel genetic variants influencing risk of stroke.


Instruction: What is influencing risk of stroke?

Output: novel genetic variants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is influencing risk of stroke?. ### Response: novel genetic variants.


Instruction: What is the locus on 12p13 near the NINJ2 gene associated with?

Output: incident ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the locus on 12p13 near the NINJ2 gene associated with?. ### Response: incident ischemic stroke.


Instruction: What is a possible effect of this locus on stroke mortality?

Output: false-positive asso-ciation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a possible effect of this locus on stroke mortality?. ### Response: false-positive asso-ciation.


Instruction: What is an association from rare variants not well represented in the subsequent replication studies?

Output: synthetic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an association from rare variants not well represented in the subsequent replication studies?. ### Response: synthetic.


Instruction: Recent meta-analyses of large case-control studies have identified novel genetic associations with specific stroke subtypes?

Output: risk factor profiles and pathologi-cal mechanisms may differ across subtypes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Recent meta-analyses of large case-control studies have identified novel genetic associations with specific stroke subtypes?. ### Response: risk factor profiles and pathologi-cal mechanisms may differ across subtypes.


Instruction: How many loci have been associated with large-vessel stroke in individuals of European ancestry?

Output: Two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many loci have been associated with large-vessel stroke in individuals of European ancestry?. ### Response: Two.


Instruction: What does MESA stand for?

Output: Multi-Ethnic Study of Atherosclerosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does MESA stand for?. ### Response: Multi-Ethnic Study of Atherosclerosis.


Instruction: What is the name of the cholesterol management guideline for statin candidates?

Output: MESA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the cholesterol management guideline for statin candidates?. ### Response: MESA.


Instruction: How old are adults with incident coronary heart disease and death?

Output: 32 to 46 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old are adults with incident coronary heart disease and death?. ### Response: 32 to 46 years.


Instruction: What is the age range of adults with coronary artery calcium in adults?

Output: 32 to 46 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the age range of adults with coronary artery calcium in adults?. ### Response: 32 to 46 years.


Instruction: When did the JAMA Cardiol. 2017 issue 2:391–9?

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the JAMA Cardiol. 2017 issue 2:391–9?. ### Response: 2017.


Instruction: What is the cost-effectiveness of coro-nary artery calcium testing among statin candidates according to the American College of Cardiology and American Heart Association cholesterol guidelines?

Output: S4.4.1.4-5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cost-effectiveness of coro-nary artery calcium testing among statin candidates according to the American College of Cardiology and American Heart Association cholesterol guidelines?. ### Response: S4.4.1.4-5.


Instruction: What improves coronary and CV risk assessment above statin indication by ESC and AHA/ACC primary prevention guidelines?

Output: CAC score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What improves coronary and CV risk assessment above statin indication by ESC and AHA/ACC primary prevention guidelines?. ### Response: CAC score.


Instruction: What does CAC score improve?

Output: coronary and CV risk assessment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CAC score improve?. ### Response: coronary and CV risk assessment.


Instruction: What is a simple disease-guided approach to personalize ACC/AHA-recommended statin allocation in elderly people?

Output: BioImage Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a simple disease-guided approach to personalize ACC/AHA-recommended statin allocation in elderly people?. ### Response: BioImage Study.


Instruction: What is the BioImage Study?

Output: A simple disease-guided approach to personalize ACC/AHA-recommended statin allocation in elderly people

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the BioImage Study?. ### Response: A simple disease-guided approach to personalize ACC/AHA-recommended statin allocation in elderly people.


Instruction: What is a guideline-based statin eligibility?

Output: coronary artery calcification, and cardiovascular events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a guideline-based statin eligibility?. ### Response: coronary artery calcification, and cardiovascular events.


Instruction: What are the 2013 American College of Cardiology/American Heart Association cholesterol guidelines?

Output: Utility of nontraditional risk markers in individuals ineligible for statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the 2013 American College of Cardiology/American Heart Association cholesterol guidelines?. ### Response: Utility of nontraditional risk markers in individuals ineligible for statin therapy.


Instruction: What is the acronym for the Multi-Ethnic Study of Atherosclerosis?

Output: MESA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the Multi-Ethnic Study of Atherosclerosis?. ### Response: MESA.


Instruction: What are the guidelines for cholesterol?

Output: American College of Cardiology and American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the guidelines for cholesterol?. ### Response: American College of Cardiology and American Heart Association.


Instruction: What are the Mortality rates in smokers and nonsmokers in the presence or absence of coronary artery calcification?

Output: S4.4.1.4-11

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Mortality rates in smokers and nonsmokers in the presence or absence of coronary artery calcification?. ### Response: S4.4.1.4-11.


Instruction: What is the J Am Coll Cardiol Img. 2012;5:1037-45?

Output: Mortality rates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the J Am Coll Cardiol Img. 2012;5:1037-45?. ### Response: Mortality rates.


Instruction: Cohen R, Budoff M, McClelland RL, et al. Significance of a positive family history for coronary heart disease in patients with a zero family history?

Output: CAC score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cohen R, Budoff M, McClelland RL, et al. Significance of a positive family history for coronary heart disease in patients with a zero family history?. ### Response: CAC score.


Instruction: What is the history for coronary heart disease in patients with zero coronary artery calcium score?

Output: posi-tive family history

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the history for coronary heart disease in patients with zero coronary artery calcium score?. ### Response: posi-tive family history.


Instruction: What is associated with an increased prevalence of coronary noncalcified plaque?

Output: HIV infection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with an increased prevalence of coronary noncalcified plaque?. ### Response: HIV infection.


Instruction: What is the association of coro-nary artery calcium with atherosclerotic cardiovascular disease (ASCVD) events?

Output: Ten-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the association of coro-nary artery calcium with atherosclerotic cardiovascular disease (ASCVD) events?. ### Response: Ten-year.


Instruction: What does MCS stand for?

Output: Multicenter AIDS Cohort Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does MCS stand for?. ### Response: Multicenter AIDS Cohort Study.


Instruction: What is the rationale for Ischemia-Guided Strategy?

Output: Risk Stratification Before Discharge

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the rationale for Ischemia-Guided Strategy?. ### Response: Risk Stratification Before Discharge.


Instruction: What is a comparison of Early Versus Delayed Angiography?

Output: e370 4.4.5

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a comparison of Early Versus Delayed Angiography?. ### Response: e370 4.4.5.


Instruction: What is the difference between Early Invasive Strategy and Ischemia-Guided Strategy?

Output: Delayed Angiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between Early Invasive Strategy and Ischemia-Guided Strategy?. ### Response: Delayed Angiography.


Instruction: What are the Care Objectives for Patients with an ischemia-guidanced strategy of NSTE-ACS?

Output: Risk Stratification Before Discharge

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the Care Objectives for Patients with an ischemia-guidanced strategy of NSTE-ACS?. ### Response: Risk Stratification Before Discharge.


Instruction: How is Risk Stratification Before Discharge for Patients With an ischemic-guided strategy?

Output: Recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is Risk Stratification Before Discharge for Patients With an ischemic-guided strategy?. ### Response: Recommendations.


Instruction: What type of angiography is recommended?

Output: Coronary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of angiography is recommended?. ### Response: Coronary.


Instruction: What is another name for Percutaneous Coronary Intervention?

Output: e372

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for Percutaneous Coronary Intervention?. ### Response: e372.


Instruction: Which type of antiplatelet agent is recommended by PCI?

Output: Oral and Intravenous

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which type of antiplatelet agent is recommended by PCI?. ### Response: Oral and Intravenous.


Instruction: What are the recommendations for GP IIb/IIIa Inhibitors?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the recommendations for GP IIb/IIIa Inhibitors?. ### Response: ............


Instruction: What is the recommendation for Anticoagulant Therapy in Patients Undergoing PCI?

Output: e374 5.2.  Timing of Urgent CABG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommendation for Anticoagulant Therapy in Patients Undergoing PCI?. ### Response: e374 5.2.  Timing of Urgent CABG.


Instruction: When is Urgent CABG recommended in Patients With NSTE-ACS?

Output: Timing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is Urgent CABG recommended in Patients With NSTE-ACS?. ### Response: Timing.


Instruction: Antiplatelet Agents: Recommendations....... e3756. Late Hospital Care, Hospital Discharge, and Posthospital Discharge Care................. e376 6.1. General Principles (Cardioprotective Therapy and Symptom Management).........

Output: 374

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Antiplatelet Agents: Recommendations....... e3756. Late Hospital Care, Hospital Discharge, and Posthospital Discharge Care................. e376 6.1. General Principles (Cardioprotective Therapy and Symptom Management).......... ### Response: 374.


Instruction: What is the term for Late Hospital and Posthospital Oral Antiplatelet Therapy?

Output: Combined Oral Anticoagulant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for Late Hospital and Posthospital Oral Antiplatelet Therapy?. ### Response: Combined Oral Anticoagulant.


Instruction: What is a term for Combined Oral anticoagulant therapy and Antiplatelets Therapy in Patients With NSTE-ACS?

Output: Oral Antiplatelet Therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a term for Combined Oral anticoagulant therapy and Antiplatelets Therapy in Patients With NSTE-ACS?. ### Response: Oral Antiplatelet Therapy.


Instruction: What is Genetic Phenotype Testing?

Output: Platelet Function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Genetic Phenotype Testing?. ### Response: Platelet Function.


Instruction: What is Risk Reduction Strategies for Secondary Prevention?

Output: Platelet Function and Genetic  Phenotype Testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Risk Reduction Strategies for Secondary Prevention?. ### Response: Platelet Function and Genetic  Phenotype Testing.


Instruction: Cardiac Rehabilitation and Physical Activity: Recommendation.................. e379 6.3.2 What is Patient Education?

Output: Recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cardiac Rehabilitation and Physical Activity: Recommendation.................. e379 6.3.2 What is Patient Education?. ### Response: Recommendations.


Instruction: How is Pneumococcal Pneumonia treated?

Output: Recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is Pneumococcal Pneumonia treated?. ### Response: Recommendation.


Instruction: What are NSAIDs?

Output: Recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are NSAIDs?. ### Response: Recommendations.


Instruction: Hormone Therapy: Recommendation.......... e380 6.3.6. What are Antioxidant Vitamins and Folic Acid?

Output: NSAIDs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Hormone Therapy: Recommendation.......... e380 6.3.6. What are Antioxidant Vitamins and Folic Acid?. ### Response: NSAIDs.


Instruction: What are Plans of Care for Patients With NSTE-ACS?

Output: Recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are Plans of Care for Patients With NSTE-ACS?. ### Response: Recommendations.


Instruction: HF: Recommendations.................... e383 7.2.1. Special Patient Groups.............................. what?

Output: Arrhythmias

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: HF: Recommendations.................... e383 7.2.1. Special Patient Groups.............................. what?. ### Response: Arrhythmias.


Instruction: NSTE-ACS in Older Patients: recommendations...................... what?!

Output: e382 7.2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: NSTE-ACS in Older Patients: recommendations...................... what?!. ### Response: e382 7.2.


Instruction: e383 7.2.2. Cardiogenic Shock: Recommendation...e386 7.3. Diabetes Mellitus: Recommandation......... e364.

Output: ...e386

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: e383 7.2.2. Cardiogenic Shock: Recommendation...e386 7.3. Diabetes Mellitus: Recommandation......... e364.. ### Response: ...e386.


Instruction: What is the name of the test that should be performed after an episode of unsta-ble angina or non-Q-wave myocardial infarction?

Output: exercise test

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the test that should be performed after an episode of unsta-ble angina or non-Q-wave myocardial infarction?. ### Response: exercise test.


Instruction: When should the exercise test (ET) be performed?

Output: at discharge

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When should the exercise test (ET) be performed?. ### Response: at discharge.


Instruction: What is the predictive value of silent isch-emia at an exercise test before discharge after an episode of unstable cor -onary artery disease?

Output: 351

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the predictive value of silent isch-emia at an exercise test before discharge after an episode of unstable cor -onary artery disease?. ### Response: 351.


Instruction: When did Heart J.123:324–31?

Output: 1992

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Heart J.123:324–31?. ### Response: 1992.


Instruction: When did a multinational study establish the value of early adenosine technetium-99m sestamibi myo-cardial perfusion imaging in identifying a low-risk group for early hos-pital discharge?

Output: after acute myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did a multinational study establish the value of early adenosine technetium-99m sestamibi myo-cardial perfusion imaging in identifying a low-risk group for early hos-pital discharge?. ### Response: after acute myocardial infarction.


Instruction: What score is used to identify diagnostic coronary disease subgroups?

Output: prognostic treadmill score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What score is used to identify diagnostic coronary disease subgroups?. ### Response: prognostic treadmill score.


Instruction: What year did Circulation issue 98:1622-30?

Output: 1998

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Circulation issue 98:1622-30?. ### Response: 1998.


Instruction: How did Morice MC, Serruys PW, Kappetein AP, et al. evaluate outcomes in patients with de novo left main disease treated with percutaneous coronary intervention?

Output: Effect of completeness of revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Morice MC, Serruys PW, Kappetein AP, et al. evaluate outcomes in patients with de novo left main disease treated with percutaneous coronary intervention?. ### Response: Effect of completeness of revascularization.


Instruction: What is the name of the trial that used paclitaxel-eluting stents to treat de novo left main disease?

Output: SYNTAX trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the trial that used paclitaxel-eluting stents to treat de novo left main disease?. ### Response: SYNTAX trial.


Instruction: What is another name for Synergy Between Percutaneous Coronary Intervention with TAXUS and Cardiac Surgery?

Output: SYNTAX

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for Synergy Between Percutaneous Coronary Intervention with TAXUS and Cardiac Surgery?. ### Response: SYNTAX.


Instruction: When was the Circulation. 2011;121:2645-53?

Output: 2010

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Circulation. 2011;121:2645-53?. ### Response: 2010.


Instruction: How long did the SYNTAX trial last?

Output: 3-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the SYNTAX trial last?. ### Response: 3-year.


Instruction: What is the name of the study that compared drug-eluting stenting with coronary bypass surgery?

Output: SYNTAX trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that compared drug-eluting stenting with coronary bypass surgery?. ### Response: SYNTAX trial.


Instruction: What is the name of the study that compares the efficacy of revascularization strategies?

Output: N Engl J Med

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that compares the efficacy of revascularization strategies?. ### Response: N Engl J Med.


Instruction: What are the names of the studies that compare coronary artery bypass in patients with left ventricular dysfunction?

Output: Synergy Between Percutaneous Coronary Intervention with TAXUS and Cardiac Surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the studies that compare coronary artery bypass in patients with left ventricular dysfunction?. ### Response: Synergy Between Percutaneous Coronary Intervention with TAXUS and Cardiac Surgery.


Instruction: In what year was the N Engl J Med published?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was the N Engl J Med published?. ### Response: 2011.


Instruction: What type of intervention in patients with acute coronary syndrome does every culprit lesion require?

Output: revascularization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of intervention in patients with acute coronary syndrome does every culprit lesion require?. ### Response: revascularization.


Instruction: What is the name of the American College of Cardiology National Cardiovascular Database Registry report?

Output: Culprit-only or multives-sel revascularization in patients with acute coronary syndromes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the American College of Cardiology National Cardiovascular Database Registry report?. ### Response: Culprit-only or multives-sel revascularization in patients with acute coronary syndromes.


Instruction: What did the American College of Cardiology publish in 2008?

Output: National Cardiovascular Database Registry report

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the American College of Cardiology publish in 2008?. ### Response: National Cardiovascular Database Registry report.


Instruction: What is the name of the registry that was used to study the use of tirofiban in patients with coronary syndromes?

Output: National Cardiovascular Database Registry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the registry that was used to study the use of tirofiban in patients with coronary syndromes?. ### Response: National Cardiovascular Database Registry.


Instruction: What is the effect of completeness of revascularization on clinical outcome in patients with multivessel disease presenting with unstable angina who undergo percutaneous coronary intervention?

Output: Comparative effec-tiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of completeness of revascularization on clinical outcome in patients with multivessel disease presenting with unstable angina who undergo percutaneous coronary intervention?. ### Response: Comparative effec-tiveness.


Instruction: When was the J Invasive Cardiol. 16:185–8 published?

Output: 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Invasive Cardiol. 16:185–8 published?. ### Response: 2004.


Instruction: What should patients with multivessel coronary syndrome have in unstable angina or non-ST-segment?

Output: exercise test

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients with multivessel coronary syndrome have in unstable angina or non-ST-segment?. ### Response: exercise test.


Instruction: What are the 2018 Cholesterol Clinical Practice GuidelinesS4.3-1 adapted from?

Output: recommendations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the 2018 Cholesterol Clinical Practice GuidelinesS4.3-1 adapted from?. ### Response: recommendations.


Instruction: Where are references to studies that support recommendations summarized?

Output: Online Data Supplements 11 and 12

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are references to studies that support recommendations summarized?. ### Response: Online Data Supplements 11 and 12.


Instruction: What are adults at intermediate risk?

Output: ≥7.5% to <20% 10-year ASCVD risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are adults at intermediate risk?. ### Response: ≥7.5% to <20% 10-year ASCVD risk.


Instruction: What reduces the risk of ASCVD in adults at intermediate risk?

Output: statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What reduces the risk of ASCVD in adults at intermediate risk?. ### Response: statin therapy.


Instruction: What should be recommended in the context of a risk discussion if a decision is made for statin therapy?

Output: a moderate-intensity statin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be recommended in the context of a risk discussion if a decision is made for statin therapy?. ### Response: a moderate-intensity statin.


Instruction: What should LDL-C levels be reduced by 30% or more in intermediate risk patients?

Output: In intermediate risk (≥7.5% to <20% 10-year ASCVD risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should LDL-C levels be reduced by 30% or more in intermediate risk patients?. ### Response: In intermediate risk (≥7.5% to <20% 10-year ASCVD risk.


Instruction: What should be reduced for optimal ASCVD risk reduction in patients at high risk?

Output: LDL-C levels should be reduced by 30% or more, and for optimal ASCVD risk reduction, especially in patients at high risk (≥20% 10-year ASCVD risk), levels should be reduced by 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be reduced for optimal ASCVD risk reduction in patients at high risk?. ### Response: LDL-C levels should be reduced by 30% or more, and for optimal ASCVD risk reduction, especially in patients at high risk (≥20% 10-year ASCVD risk), levels should be reduced by 50%.


Instruction: What should be reduced by 50% or more?

Output: LDL-C levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be reduced by 50% or more?. ### Response: LDL-C levels.


Instruction: In adults 40 to 75 years of age with diabetes, moderate-intensity statin therapy is indicated?

Output: S4.3-1I A3.  In adults 40 to 75 years of age with diabetes, regardless of estimated 10-year ASCVD risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In adults 40 to 75 years of age with diabetes, moderate-intensity statin therapy is indicated?. ### Response: S4.3-1I A3.  In adults 40 to 75 years of age with diabetes, regardless of estimated 10-year ASCVD risk.


Instruction: What is indicated in patients 20 to 75 years of age with an LDL-C level of 190 mg/dL or higher?

Output: maximally tolerated statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is indicated in patients 20 to 75 years of age with an LDL-C level of 190 mg/dL or higher?. ### Response: maximally tolerated statin therapy.


Instruction: What is included from recommendations in the 2018 Cholesterol Clinical Practice Guidelines?

Output: S4.3-28,S4.3-34

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is included from recommendations in the 2018 Cholesterol Clinical Practice Guidelines?. ### Response: S4.3-28,S4.3-34.


Instruction: In adults with diabetes mellitus who have multiple ASCVD risk factors, it is reasonable to prescribe high-intensity statin therapy with the aim to reduce LDL-C levels by what percentage or more?

Output: 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In adults with diabetes mellitus who have multiple ASCVD risk factors, it is reasonable to prescribe high-intensity statin therapy with the aim to reduce LDL-C levels by what percentage or more?. ### Response: 50%.


Instruction: What percentage of the population is at risk for ASCVD?

Output: .5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the population is at risk for ASCVD?. ### Response: .5%.


Instruction: What type of factors favor initiation or intensification of statin therapy?

Output: risk-enhancing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of factors favor initiation or intensification of statin therapy?. ### Response: risk-enhancing.


Instruction: What percentage of ASCVD risk are intermediate-risk adults?

Output: ≥7.5% to <20%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of ASCVD risk are intermediate-risk adults?. ### Response: ≥7.5% to <20%.


Instruction: What percentage is selected borderline-risk?

Output: 5% to <7.5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage is selected borderline-risk?. ### Response: 5% to <7.5%.


Instruction: Why is a coronary artery calcium score measured?

Output: for the purpose of making a treatment decision

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why is a coronary artery calcium score measured?. ### Response: for the purpose of making a treatment decision.


Instruction: If the coronary artery calcium score is zero, it is reasonable to withhold statin therapy and reassess in how many years?

Output: 5 to 10 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: If the coronary artery calcium score is zero, it is reasonable to withhold statin therapy and reassess in how many years?. ### Response: 5 to 10 years.


Instruction: Diabetes, family history of premature CHD, cigarette smoking are examples of what?

Output: higher-risk conditions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Diabetes, family history of premature CHD, cigarette smoking are examples of what?. ### Response: higher-risk conditions.


Instruction: What is the range of a coronary artery calcium score?

Output: 100

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the range of a coronary artery calcium score?. ### Response: 100.


Instruction: What is it reasonable to initiate statin therapy for patients 55 years of age?

Output: coronary artery calcium score is 1 to 99

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is it reasonable to initiate statin therapy for patients 55 years of age?. ### Response: coronary artery calcium score is 1 to 99.


Instruction: If coronary arterial calcium score is 100 or higher or in the 75th percentile or higher, it is reasonable to start what?

Output: statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: If coronary arterial calcium score is 100 or higher or in the 75th percentile or higher, it is reasonable to start what?. ### Response: statin therapy.


Instruction: What is the name of the book that describes the individualization of bacteraemia in patients with a permanent endocardial pacemaker?

Output: ClinMicrobiol Infect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the book that describes the individualization of bacteraemia in patients with a permanent endocardial pacemaker?. ### Response: ClinMicrobiol Infect.


Instruction: When was the book published online before print?

Output: May 16, 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the book published online before print?. ### Response: May 16, 2009.


Instruction: Where is the book available?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the book available?. ### Response: http://www3.interscience.wiley.com.


Instruction: What year was this study conducted?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was this study conducted?. ### Response: 1999.


Instruction: What is the name of the study that was conducted in 2009?

Output: Circ Arrhythm Elec-trophysiol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that was conducted in 2009?. ### Response: Circ Arrhythm Elec-trophysiol.


Instruction: What is one stage side-to-side replacement of infected pulse generators and leads?

Output: Percutaneous lead implantation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one stage side-to-side replacement of infected pulse generators and leads?. ### Response: Percutaneous lead implantation.


Instruction: Pacing Clin Electrophysiol. 2006;29:875–879.78.

Output: Percutaneous lead implantation connected to an externaldevice in stimulation-dependent patients with systemic infection

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Pacing Clin Electrophysiol. 2006;29:875–879.78.. ### Response: Percutaneous lead implantation connected to an externaldevice in stimulation-dependent patients with systemic infection.


Instruction: What year did Clin Electrophysiol publish a report on the use of pacemakers?

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Clin Electrophysiol publish a report on the use of pacemakers?. ### Response: 2006.


Instruction: What is the name of the organization that is responsible for the EmergingInfections Network?

Output: Infectious Diseases Society of America

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the organization that is responsible for the EmergingInfections Network?. ### Response: Infectious Diseases Society of America.


Instruction: In what year was the Indian Heart J published?

Output: 1996

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year was the Indian Heart J published?. ### Response: 1996.


Instruction: What is suppressive antimicrobial therapy for?

Output: intravascular device-related infections

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is suppressive antimicrobial therapy for?. ### Response: intravascular device-related infections.


Instruction: What are the risks ofpontaneous injury and extraction of an active fixation pacemaker?

Output: Risks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the risks ofpontaneous injury and extraction of an active fixation pacemaker?. ### Response: Risks.


Instruction: What is the name of the multicenter clinical study that reported the Accufix Multicenter Clinical Study and WorldwideRegistry?

Output: fixation pacemaker lead

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multicenter clinical study that reported the Accufix Multicenter Clinical Study and WorldwideRegistry?. ### Response: fixation pacemaker lead.


Instruction: When did Circulation. 1999.100:2344–2352.83?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circulation. 1999.100:2344–2352.83?. ### Response: 1999.


Instruction: What did Bracke F, Meijer A, Van Gelder B do?

Output: Extraction of pacemaker andimplantable cardioverter defibrillator leads

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Bracke F, Meijer A, Van Gelder B do?. ### Response: Extraction of pacemaker andimplantable cardioverter defibrillator leads.


Instruction: What is the name of the journal that deals with the treatment of patients with infected cardioverter-defibrillator systems?

Output: J Thorac Car-diovasc Surg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that deals with the treatment of patients with infected cardioverter-defibrillator systems?. ### Response: J Thorac Car-diovasc Surg.


Instruction: What are the names of the journals that deal with undertreatment and overtreatment of patients?

Output: 122387704

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the journals that deal with undertreatment and overtreatment of patients?. ### Response: 122387704.


Instruction: How long did it take to treat endocarditis in Goteborg?

Output: 18 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take to treat endocarditis in Goteborg?. ### Response: 18 years.


Instruction: What is the name of the study that investigated the treatment of patients with infectedantiarrhythmic implantable devices?

Output: Molina JE

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated the treatment of patients with infectedantiarrhythmic implantable devices?. ### Response: Molina JE.


Instruction: What type of endocarditis complicates permanent pacemaker and implantable cardioverter-defibrillator infection?

Output: Infective

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of endocarditis complicates permanent pacemaker and implantable cardioverter-defibrillator infection?. ### Response: Infective.


Instruction: When did Mayo Clin Proceed issue 83:46–53.88?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Mayo Clin Proceed issue 83:46–53.88?. ### Response: 2008.


Instruction: What are the risk factors for mortality in patients with cardiac device-related infections?

Output: Baman TS, Gupta SK, Valle JA, Yamada E. Risk factors for mortalityin patients with cardiac device-related infection. Circ Arrhythm Elec-trophysiol . 2009;2:129–134

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the risk factors for mortality in patients with cardiac device-related infections?. ### Response: Baman TS, Gupta SK, Valle JA, Yamada E. Risk factors for mortalityin patients with cardiac device-related infection. Circ Arrhythm Elec-trophysiol . 2009;2:129–134.


Instruction: What is a PFO with high-risk anatomic features?

Output: larger shunt size and atrial sep-tal aneurysm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a PFO with high-risk anatomic features?. ### Response: larger shunt size and atrial sep-tal aneurysm.


Instruction: What is the reason to choose closure with a transcatheter device and long-term antiplatelet therapy?

Output: preventing recurrent stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the reason to choose closure with a transcatheter device and long-term antiplatelet therapy?. ### Response: preventing recurrent stroke.


Instruction: How old are patients 18 to 60 years of age?

Output: 18 to 60 years of age with a nonla-cunar ischemic stroke of undetermined cause despite a thorough evaluation and a PFO without high-risk anatomic features, * the ben-efit of closure with a transcatheter device and long-term antiplatelet therapy over antiplatelet therapy alone for preventing recurrent stroke is not well established,552–5572b C-LD4.  In patients 18 to 60 years of age with a nonlacunar ischemic stroke of undetermined cause despite a thorough evaluation and a PFO, the comparative benefit of closure with a transcatheter device versus warfarin is unknown

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old are patients 18 to 60 years of age?. ### Response: 18 to 60 years of age with a nonla-cunar ischemic stroke of undetermined cause despite a thorough evaluation and a PFO without high-risk anatomic features, * the ben-efit of closure with a transcatheter device and long-term antiplatelet therapy over antiplatelet therapy alone for preventing recurrent stroke is not well established,552–5572b C-LD4.  In patients 18 to 60 years of age with a nonlacunar ischemic stroke of undetermined cause despite a thorough evaluation and a PFO, the comparative benefit of closure with a transcatheter device versus warfarin is unknown.


Instruction: How old is 60 years of age with a nonla-cunar ischemic stroke of undetermined cause?

Output: 18 to 60 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How old is 60 years of age with a nonla-cunar ischemic stroke of undetermined cause?. ### Response: 18 to 60 years.


Instruction: What is not well established for preventing recurrent stroke?

Output: ben-efit of closure with a transcatheter device and long-term antiplatelet therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not well established for preventing recurrent stroke?. ### Response: ben-efit of closure with a transcatheter device and long-term antiplatelet therapy.


Instruction: What is the comparative benefit of closure with a transcatheter device versus warfarin?

Output: unknown

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the comparative benefit of closure with a transcatheter device versus warfarin?. ### Response: unknown.


Instruction: What is the difference between a transcatheter device and warfarin?

Output: comparative benefit of closure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between a transcatheter device and warfarin?. ### Response: comparative benefit of closure.


Instruction: How does each study define high-risk anatomic features?

Output: in a different way

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does each study define high-risk anatomic features?. ### Response: in a different way.


Instruction: What led to randomized trials of PFO device closure?

Output: Substantial epidemiological evidence suggesting a causal role of PFO for stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What led to randomized trials of PFO device closure?. ### Response: Substantial epidemiological evidence suggesting a causal role of PFO for stroke.


Instruction: How many trials compared device closure with antiplatelet or anti-coagulant treatment?

Output: 3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many trials compared device closure with antiplatelet or anti-coagulant treatment?. ### Response: 3.


Instruction: How many of the first 3 trials showed a non-significant trend toward benefit of device closure?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many of the first 3 trials showed a non-significant trend toward benefit of device closure?. ### Response: 2.


Instruction: Antiplatelet treatment alone showed a significant benefit of what?

Output: PFO closure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Antiplatelet treatment alone showed a significant benefit of what?. ### Response: PFO closure.


Instruction: What did an additional positive trial553 limit eligibility to?

Output: patients with high-risk anatomic PFO features

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did an additional positive trial553 limit eligibility to?. ### Response: patients with high-risk anatomic PFO features.


Instruction: A meta-analysis of all trials561 found that patients with high-risk anatomic PFO features were eligible?

Output: An additional positive trial553

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A meta-analysis of all trials561 found that patients with high-risk anatomic PFO features were eligible?. ### Response: An additional positive trial553.


Instruction: What was the number needed to treat with device closure to pre-vent 1 recurrent stroke?

Output: 131

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the number needed to treat with device closure to pre-vent 1 recurrent stroke?. ### Response: 131.


Instruction: How many people-years of follow-up did a meta-analysis of all trials561 find?

Output: 10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people-years of follow-up did a meta-analysis of all trials561 find?. ### Response: 10.


Instruction: What is clinically important in this generally young population?

Output: device closure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is clinically important in this generally young population?. ### Response: device closure.


Instruction: What was the rate of serious periprocedural complica-tion, including AF, in patients  60 years of age?

Output: 4.9%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the rate of serious periprocedural complica-tion, including AF, in patients  60 years of age?. ### Response: 4.9%.


Instruction: How are RCT data of PFO closure in patients > 60 years old limited?

Output: extremely limited

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are RCT data of PFO closure in patients > 60 years old limited?. ### Response: extremely limited.


Instruction: What is the rate of serious periproce-dural complications in the older age group?

Output: 10.9%).

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the rate of serious periproce-dural complications in the older age group?. ### Response: 10.9%)..


Instruction: What should be based on joint input from a neurologist with expertise in vas-cular neurology?

Output: Recommendations for secondary stroke preven-tion in a patient with a PFO

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be based on joint input from a neurologist with expertise in vas-cular neurology?. ### Response: Recommendations for secondary stroke preven-tion in a patient with a PFO.


Instruction: What is the specialty of a cardiologist with expertise in PFO closure?

Output: neurologist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the specialty of a cardiologist with expertise in PFO closure?. ### Response: neurologist.


Instruction: How many patients were included in a small trial with 120 patients?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were included in a small trial with 120 patients?. ### Response: 1.


Instruction: When were the Recommendations for PFO downloaded?

Output: April 28, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When were the Recommendations for PFO downloaded?. ### Response: April 28, 2023.


Instruction: What should be addressed in subsequent follow-up visits?

Output: the following

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be addressed in subsequent follow-up visits?. ### Response: the following.


Instruction: What is the level of evidence for GDMT?

Output: B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the level of evidence for GDMT?. ### Response: B.


Instruction: What are multidisciplinary HF disease-management programs recommended for?

Output: patients at high risk for hospital read-mission

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are multidisciplinary HF disease-management programs recommended for?. ### Response: patients at high risk for hospital read-mission.


Instruction: What type of HF therapy should be adjusted as appropriate?

Output: Multidisciplinary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of HF therapy should be adjusted as appropriate?. ### Response: Multidisciplinary.


Instruction: What is recommended for patients at high risk for hospital read-mission?

Output: Multidisciplinary HF disease-management programs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended for patients at high risk for hospital read-mission?. ### Response: Multidisciplinary HF disease-management programs.


Instruction: What are multidisciplinary HF disease-management programs?

Output: recommended for patients at high risk for hospital read-mission

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are multidisciplinary HF disease-management programs?. ### Response: recommended for patients at high risk for hospital read-mission.


Instruction: How long is a follow-up visit?

Output: within 7 to 14days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is a follow-up visit?. ### Response: within 7 to 14days.


Instruction: How many days are reasonable to schedule an early follow-up visit?

Output: 7 to 14days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many days are reasonable to schedule an early follow-up visit?. ### Response: 7 to 14days.


Instruction: How long is the timeframe for an early telephone follow up?

Output: within 3 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is the timeframe for an early telephone follow up?. ### Response: within 3 days.


Instruction: What is the level of evidence for using clinical risk-prediction tools and biomarkers?

Output: B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the level of evidence for using clinical risk-prediction tools and biomarkers?. ### Response: B.


Instruction: What is the level of evidence for HFA?

Output: B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the level of evidence for HFA?. ### Response: B.


Instruction: What are the additional and important comorbidities that occur in patients with HF referenced in?

Output: Table 24

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the additional and important comorbidities that occur in patients with HF referenced in?. ### Response: Table 24.


Instruction: What is CABG?

Output: medical therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is CABG?. ### Response: medical therapy.


Instruction: What type of intervention is indicated for patients with angina and suitable coronary anatomy?

Output: Coronary artery revascularization via coronary artery bypassgraft surgery (CABG) or percutaneous intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of intervention is indicated for patients with angina and suitable coronary anatomy?. ### Response: Coronary artery revascularization via coronary artery bypassgraft surgery (CABG) or percutaneous intervention.


Instruction: What percentage of patients have a left main stenosis?

Output: >50%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients have a left main stenosis?. ### Response: >50%).


Instruction: What is the level of evidence for CABG?

Output: B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the level of evidence for CABG?. ### Response: B.


Instruction: In patients with mild to moderate LV systolic dysfunction, what percentage is CABG reasonable?

Output: EF 35% to 50%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with mild to moderate LV systolic dysfunction, what percentage is CABG reasonable?. ### Response: EF 35% to 50%).


Instruction: What is multivessel CAD?

Output: proximal left anterior descending coronary artery stenosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is multivessel CAD?. ### Response: proximal left anterior descending coronary artery stenosis.


Instruction: When viable myocardium is present in the region of intendedrevascularization what is reasonable to improve morbidity and cardiovascular mortality for patients with severe LVdysfunction?

Output: CABG or medical therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When viable myocardium is present in the region of intendedrevascularization what is reasonable to improve morbidity and cardiovascular mortality for patients with severe LVdysfunction?. ### Response: CABG or medical therapy.


Instruction: What is reasonable for patients with critical aortic stenosis and a predicted surgicalmortality of no greater than 10%?

Output: Surgical aortic valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable for patients with critical aortic stenosis and a predicted surgicalmortality of no greater than 10%?. ### Response: Surgical aortic valve replacement.


Instruction: Who is a Content Reviewer at the University of Pennsylvania?

Output: Howard C. Herrmann

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a Content Reviewer at the University of Pennsylvania?. ### Response: Howard C. Herrmann.


Instruction: Who is the Director ofInterventional CardiologyProgram at the Perelman School ofMedicine?

Output: Professor ofMedicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Director ofInterventional CardiologyProgram at the Perelman School ofMedicine?. ### Response: Professor ofMedicine.


Instruction: Who is a Content Reviewer at Mayo Clinic?

Output: Fred M. Kosumoto

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a Content Reviewer at Mayo Clinic?. ### Response: Fred M. Kosumoto.


Instruction: What is the name of the professor at Stanford University School ofMedicine?

Output: David J. Maron

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor at Stanford University School ofMedicine?. ### Response: David J. Maron.


Instruction: Who is a professor of medicine at the University of Arizona?

Output: Douglass A. Morrison

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a professor of medicine at the University of Arizona?. ### Response: Douglass A. Morrison.


Instruction: What is the name of the content reviewer at Arizona State University?

Output: Douglass A. Morrison

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the content reviewer at Arizona State University?. ### Response: Douglass A. Morrison.


Instruction: Who is an Associate Professor of Medicine at the Duke University MedicalCenter?

Output: Manesh R. Patel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is an Associate Professor of Medicine at the Duke University MedicalCenter?. ### Response: Manesh R. Patel.


Instruction: What is the name of the professor of medicine at the University Hospitals CaseMedical Center?

Output: Associate Professorof Medicine/C15Bayer Healthcare */C15JanssenPharmaceuticals *None None /C15Johnson & Johnson * None NoneM. Eugene Sherman Content Reviewer —ACCBoard of GovernorsAurora Denver Cardiology None None None None /C15Bristol-MyersSquibb */C15Hospira *NoneDaniel I. Simon

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor of medicine at the University Hospitals CaseMedical Center?. ### Response: Associate Professorof Medicine/C15Bayer Healthcare */C15JanssenPharmaceuticals *None None /C15Johnson & Johnson * None NoneM. Eugene Sherman Content Reviewer —ACCBoard of GovernorsAurora Denver Cardiology None None None None /C15Bristol-MyersSquibb */C15Hospira *NoneDaniel I. Simon.


Instruction: What is the name of the Content Reviewer at Summit Medical Group?

Output: William A. Tansey III

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Content Reviewer at Summit Medical Group?. ### Response: William A. Tansey III.


Instruction: Who is the Chief, Division of Cardiology at San Francisco GeneralHospital?

Output: David D. Waters

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Chief, Division of Cardiology at San Francisco GeneralHospital?. ### Response: David D. Waters.


Instruction: What is the title of the Chief of Cardiology Division at the San Francisco GeneralHospital?

Output: Chief

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of the Chief of Cardiology Division at the San Francisco GeneralHospital?. ### Response: Chief.


Instruction: What does ACC/AHA/SCAI focus on in 2015?

Output: Primary PCI1249

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ACC/AHA/SCAI focus on in 2015?. ### Response: Primary PCI1249.


Instruction: Why did the panel favor 4-factor PCC overFFP?

Output: ease of administration, the increased probability ofachieving a near-normalized INR, and the lower risk of volumeoverload

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why did the panel favor 4-factor PCC overFFP?. ### Response: ease of administration, the increased probability ofachieving a near-normalized INR, and the lower risk of volumeoverload.


Instruction: What is a particularly important consideration for intracranial bleeding?

Output: speed of reversal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a particularly important consideration for intracranial bleeding?. ### Response: speed of reversal.


Instruction: What is a particularly important consideration?

Output: speed of reversal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a particularly important consideration?. ### Response: speed of reversal.


Instruction: What is the cost-effectiveness of 4-factor PCC vs. FFP?

Output: payer perspective in various health care systems

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the cost-effectiveness of 4-factor PCC vs. FFP?. ### Response: payer perspective in various health care systems.


Instruction: What is the thromboembolic risk associated with4-factor PCC administration compared with the same risk forpatients treated with FFP?

Output: true magnitude of increased thromboembolic risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the thromboembolic risk associated with4-factor PCC administration compared with the same risk forpatients treated with FFP?. ### Response: true magnitude of increased thromboembolic risk.


Instruction: What should be used for patients with life-threatening bleeding during oraldirect Xa inhibitor treatment of VTE?

Output: cessation of direct Xainhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be used for patients with life-threatening bleeding during oraldirect Xa inhibitor treatment of VTE?. ### Response: cessation of direct Xainhibitor.


Instruction: How many approaches have emerged for life-threatening bleeding related to direct Xainhibitor?

Output: Two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many approaches have emerged for life-threatening bleeding related to direct Xainhibitor?. ### Response: Two.


Instruction: What was formerly known as andexanet alpha?

Output: inactivated-zhzo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was formerly known as andexanet alpha?. ### Response: inactivated-zhzo.


Instruction: What is a coagulation factor Xa?

Output: recombinant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a coagulation factor Xa?. ### Response: recombinant.


Instruction: What is an inactivated-zhzo?

Output: recombinant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an inactivated-zhzo?. ### Response: recombinant.


Instruction: What does the ASH guideline panel suggest using as an addition to cessation of oral direct Xa inhibitor?

Output: 4-factor PCC administration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the ASH guideline panel suggest using as an addition to cessation of oral direct Xa inhibitor?. ### Response: 4-factor PCC administration.


Instruction: What is the conditional recommendation based on very low certainty in theevidence about effects?

Output: Å◯◯◯

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the conditional recommendation based on very low certainty in theevidence about effects?. ### Response: Å◯◯◯.


Instruction: What does this recommendation not apply to?

Output: non –life-threatening bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does this recommendation not apply to?. ### Response: non –life-threatening bleeding.


Instruction: What is available to compare the efficacy of 4-factor PCC and coagulationfactor Xa?

Output: No data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is available to compare the efficacy of 4-factor PCC and coagulationfactor Xa?. ### Response: No data.


Instruction: The guideline panel of-fers no recommendation for which approach?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The guideline panel of-fers no recommendation for which approach?. ### Response: 1.


Instruction: How many systematic reviews did we find that addressed this question?

Output: no

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many systematic reviews did we find that addressed this question?. ### Response: no.


Instruction: How many individualstudies did we identify?

Output: 8

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many individualstudies did we identify?. ### Response: 8.


Instruction: What were the patients receiving direct Xa inhibitors experiencing?

Output: major bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the patients receiving direct Xa inhibitors experiencing?. ### Response: major bleeding.


Instruction: What is shown online at https://dbep.gradepro.org/profile/2ec6099d-9b00-4bac-bc31-34653ee10737?

Output: The EtD framework

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is shown online at https://dbep.gradepro.org/profile/2ec6099d-9b00-4bac-bc31-34653ee10737?. ### Response: The EtD framework.


Instruction: What is the evidence profile in the EtDframework referenced at the end of the previous section?

Output: Benefits

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the evidence profile in the EtDframework referenced at the end of the previous section?. ### Response: Benefits.


Instruction: What is fenoldopam infusion forrenal protection in high-risk cardiac surgery patients?

Output: a randomizedclinical study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is fenoldopam infusion forrenal protection in high-risk cardiac surgery patients?. ### Response: a randomizedclinical study.


Instruction: When was the J Cardiothorac Vasc Anesth.21:847–50.986 published?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Cardiothorac Vasc Anesth.21:847–50.986 published?. ### Response: 2007.


Instruction: Who is the author of the 2011 ACCF/AHA CABG Guideline?

Output: CardiopulmonaryHillis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of the 2011 ACCF/AHA CABG Guideline?. ### Response: CardiopulmonaryHillis.


Instruction: Who edited the 2011 ACCF/AHA CABG Guideline e723?

Output: CardiopulmonaryHillis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who edited the 2011 ACCF/AHA CABG Guideline e723?. ### Response: CardiopulmonaryHillis.


Instruction: When did Utley JR's guideline become available?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Utley JR's guideline become available?. ### Response: 2011.


Instruction: What may patients with IST have particularly refractory symptoms?

Output: single-drug efficacy may be limited

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may patients with IST have particularly refractory symptoms?. ### Response: single-drug efficacy may be limited.


Instruction: What may be limited by single-drug efficacy?

Output: Some patients with IST may have particularly refractory symptoms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be limited by single-drug efficacy?. ### Response: Some patients with IST may have particularly refractory symptoms.


Instruction: In a small observational study, what reduced the heart rate from baseline to a greater extent?

Output: ivabradine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In a small observational study, what reduced the heart rate from baseline to a greater extent?. ### Response: ivabradine.


Instruction: What did ivabradine and metoprolol reduce the heart rate from?

Output: baseline

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did ivabradine and metoprolol reduce the heart rate from?. ### Response: baseline.


Instruction: What was well tolerated on combination therapy?

Output: combined therapy was well tolerated. In the SHIFT and BEAUTIFUL studies, the majority of patients were taking the combination of ivabradine and a beta blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was well tolerated on combination therapy?. ### Response: combined therapy was well tolerated. In the SHIFT and BEAUTIFUL studies, the majority of patients were taking the combination of ivabradine and a beta blocker.


Instruction: In SHIFT and BEAUTIFUL studies, what did the majority of patients take?

Output: ivabradine and a beta blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In SHIFT and BEAUTIFUL studies, what did the majority of patients take?. ### Response: ivabradine and a beta blocker.


Instruction: What is phosphenes?

Output: an enhanced brightness in a portion of the visual field

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is phosphenes?. ### Response: an enhanced brightness in a portion of the visual field.


Instruction: What can ivabradine cause?

Output: phosphenes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can ivabradine cause?. ### Response: phosphenes.


Instruction: What side effect was reported in 3% of patients taking the drug in the SHIFT trial?

Output: phosphenes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What side effect was reported in 3% of patients taking the drug in the SHIFT trial?. ### Response: phosphenes.


Instruction: How many patients were reported to have increased brightness in a portion of the visual field?

Output: 3%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were reported to have increased brightness in a portion of the visual field?. ### Response: 3%.


Instruction: What may lead to underestimation of lesion severity by angiography in diffusely diseased coronary arteries?

Output: lack of a normal reference segment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may lead to underestimation of lesion severity by angiography in diffusely diseased coronary arteries?. ### Response: lack of a normal reference segment.