Instruction: What is an increased risk of early after operation?

Output: ischemic stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an increased risk of early after operation?. ### Response: ischemic stroke.


Instruction: In the first 90 to 180 days after either bioprosthetic AVR or mitral valve replacement, what is the risk of ischemic stroke?

Output: increased risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the first 90 to 180 days after either bioprosthetic AVR or mitral valve replacement, what is the risk of ischemic stroke?. ### Response: increased risk.


Instruction: Anticoagulation early after valve implantation is intended to decrease the risk of what?

Output: thromboembolism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Anticoagulation early after valve implantation is intended to decrease the risk of what?. ### Response: thromboembolism.


Instruction: The potential ben-efit of anticoagulation therapy must be weighed against what risk of bleeding?

Output: major or life-threatening bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The potential ben-efit of anticoagulation therapy must be weighed against what risk of bleeding?. ### Response: major or life-threatening bleeding.


Instruction: What is the goal INR for a mechanical On-X AVR with no thromboembolic risk factors?

Output: 1.5–2.0

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the goal INR for a mechanical On-X AVR with no thromboembolic risk factors?. ### Response: 1.5–2.0.


Instruction: How many mg of aspirin is needed to achieve an INR of 1.5-2.0?

Output: 75–100

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mg of aspirin is needed to achieve an INR of 1.5-2.0?. ### Response: 75–100.


Instruction: What is a nonrandomized figure 12?

Output: Antithrombotic therapy for prosthetic valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a nonrandomized figure 12?. ### Response: Antithrombotic therapy for prosthetic valves.


Instruction: What is a goal INR of 1.5-2.0 plus aspirin 75-100 mg daily?

Output: ≥3 months after surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a goal INR of 1.5-2.0 plus aspirin 75-100 mg daily?. ### Response: ≥3 months after surgery.


Instruction: What does ASA mean?

Output: aspirin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ASA mean?. ### Response: aspirin.


Instruction: AVR stands for what?

Output: aortic valve replacement

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: AVR stands for what?. ### Response: aortic valve replacement.


Instruction: What is effective for the rapid detection of acute ICH?

Output: NCCT scanning

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is effective for the rapid detection of acute ICH?. ### Response: NCCT scanning.


Instruction: What was the only neuroimaging modality used in the National Institute of Neurological Disorders and Stroke trials?

Output: NCCT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the only neuroimaging modality used in the National Institute of Neurological Disorders and Stroke trials?. ### Response: NCCT.


Instruction: What is ECASS?

Output: European Cooperative Acute Stroke Study) III

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ECASS?. ### Response: European Cooperative Acute Stroke Study) III.


Instruction: What provides high value for patients with acute stroke?

Output: Immediate CT scanning

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What provides high value for patients with acute stroke?. ### Response: Immediate CT scanning.


Instruction: MRI was as accurate as NCCT in detecting hyperacute intraparenchymal hemorrhage in patients with stroke symptoms?

Output: 84,85 MRI was as accurate as NCCT in detecting hyperacute intraparenchymal hemorrhage in patients presenting with stroke symptoms within 6 hours of onset when gradient echo sequences were used

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: MRI was as accurate as NCCT in detecting hyperacute intraparenchymal hemorrhage in patients with stroke symptoms?. ### Response: 84,85 MRI was as accurate as NCCT in detecting hyperacute intraparenchymal hemorrhage in patients presenting with stroke symptoms within 6 hours of onset when gradient echo sequences were used.


Instruction: What was used to detect hyperacute intraparenchymal hemorrhage in patients with stroke symptoms within 6 hours of onset?

Output: gradient echo sequences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was used to detect hyperacute intraparenchymal hemorrhage in patients with stroke symptoms within 6 hours of onset?. ### Response: gradient echo sequences.


Instruction: What is FLAIR?

Output: diffusion-positive fluid-attenuated inversion recovery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is FLAIR?. ### Response: diffusion-positive fluid-attenuated inversion recovery.


Instruction: What can be useful for selecting those who can benefit from IV alteplase administration within 4.5 hours of stroke symptom recognition?

Output: MRI to identify diffusion-positive fluid-attenuated inversion recovery (FLAIR)–negative lesions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be useful for selecting those who can benefit from IV alteplase administration within 4.5 hours of stroke symptom recognition?. ### Response: MRI to identify diffusion-positive fluid-attenuated inversion recovery (FLAIR)–negative lesions.


Instruction: CTA with CTP or MRA with DW-MRI with or without MR perfusion is helpful for selecting candidates for what?

Output: mechanical thrombectomy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: CTA with CTP or MRA with DW-MRI with or without MR perfusion is helpful for selecting candidates for what?. ### Response: mechanical thrombectomy.


Instruction: What is useful for selecting candidates for mechanical thrombectomy between 6 and 24 hours after last known well?

Output: CTA with CTP or MRA with DW-MRI with or without MR perfusion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is useful for selecting candidates for mechanical thrombectomy between 6 and 24 hours after last known well?. ### Response: CTA with CTP or MRA with DW-MRI with or without MR perfusion.


Instruction: Tables XVII through XX are in what?

Output: online Data Supplement 1.2.2.2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Tables XVII through XX are in what?. ### Response: online Data Supplement 1.2.2.2.


Instruction: What are CMBs?

Output: cerebral microbleeds

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are CMBs?. ### Response: cerebral microbleeds.


Instruction: What is the recommended dose of IV alteplase in eligible patients without first obtaining MRI to exclude?

Output: cerebral microbleeds

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommended dose of IV alteplase in eligible patients without first obtaining MRI to exclude?. ### Response: cerebral microbleeds.


Instruction: In what percentage of patients receiving IV altepase, what is CMB common in?

Output: 15% to 27%.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what percentage of patients receiving IV altepase, what is CMB common in?. ### Response: 15% to 27%..


Instruction: What were the pivotal NINDS and ECASS III trials that established the benefits of IV alteplase treatment?

Output: rt-PA (Recombinant Tissue-Type Plasminogen Activator) trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the pivotal NINDS and ECASS III trials that established the benefits of IV alteplase treatment?. ### Response: rt-PA (Recombinant Tissue-Type Plasminogen Activator) trials.


Instruction: What did two meta-analyses of the association of baseline CMBs and the risk of sICH report?

Output: that sICH is more common in patients with baseline CMBs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did two meta-analyses of the association of baseline CMBs and the risk of sICH report?. ### Response: that sICH is more common in patients with baseline CMBs.


Instruction: How many studies used ECASS II sICH criteria?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies used ECASS II sICH criteria?. ### Response: 2.


Instruction: What were the rates in patients with CMBs?

Output: 5.8% and 6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the rates in patients with CMBs?. ### Response: 5.8% and 6.


Instruction: What is the risk of sICH in patients with CMBs detected after IV alteplase treatment?

Output: 5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk of sICH in patients with CMBs detected after IV alteplase treatment?. ### Response: 5%.


Instruction: What was the risk in the NINDS criteria in the tPA trials?

Output: 6.4%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the risk in the NINDS criteria in the tPA trials?. ### Response: 6.4%.


Instruction: What percentage of patients had no CMBs?

Output: 1%–4.4%).

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients had no CMBs?. ### Response: 1%–4.4%)..


Instruction: How many patients were included in the study?

Output: <50

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were included in the study?. ### Response: <50.


Instruction: What was reported as significantly greater than in those with no CDMs (1%-4.4%)?

Output: The risk of sICH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was reported as significantly greater than in those with no CDMs (1%-4.4%)?. ### Response: The risk of sICH.


Instruction: What is the name of the multicenter prospective clinical trial of the Cardica C-PortSystem?

Output: PREVENT IV

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multicenter prospective clinical trial of the Cardica C-PortSystem?. ### Response: PREVENT IV.


Instruction: When was the J ThoracCardiovasc Surg published?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J ThoracCardiovasc Surg published?. ### Response: 2005.


Instruction: How many patients were evaluated for intraoperative grafts assessment?

Output: 1258

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were evaluated for intraoperative grafts assessment?. ### Response: 1258.


Instruction: What is edifoligide an E2F transcription factor decoy for?

Output: prevention ofvein graft failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is edifoligide an E2F transcription factor decoy for?. ### Response: prevention ofvein graft failure.


Instruction: What is the name of the randomized controlled trial?

Output: PREVENT IV

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized controlled trial?. ### Response: PREVENT IV.


Instruction: What is Taggart DP?

Output: Intraoperative imaging techniques toassess coronary artery bypass graft patency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Taggart DP?. ### Response: Intraoperative imaging techniques toassess coronary artery bypass graft patency.


Instruction: Intraoperative imaging techniques toassess coronary artery bypass graft patency.

Output: Balacumaraswami L, Taggart DP. Intraoperative imaging techniques toassess coronary artery bypass graft patency. Ann Thorac Surg. 2007;83:2251–7.1262

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Intraoperative imaging techniques toassess coronary artery bypass graft patency.. ### Response: Balacumaraswami L, Taggart DP. Intraoperative imaging techniques toassess coronary artery bypass graft patency. Ann Thorac Surg. 2007;83:2251–7.1262.


Instruction: What is the name of the study that evaluated local perivascular delivery of basic fibroblast growth factor in patients undergoing coronary bypass surgery?

Output: phase I randomized, double-blind, placebo-controlled trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated local perivascular delivery of basic fibroblast growth factor in patients undergoing coronary bypass surgery?. ### Response: phase I randomized, double-blind, placebo-controlled trial.


Instruction: What is a high fidelity tissue-based cardiac surgical procedure?

Output: simulator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a high fidelity tissue-based cardiac surgical procedure?. ### Response: simulator.


Instruction: What is a high fidelity tissue-based cardiac surgical simulator?

Output: Cardica C-PortSystem

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a high fidelity tissue-based cardiac surgical simulator?. ### Response: Cardica C-PortSystem.


Instruction: When was the Eur J Cardiothorac Surg.27:910–6 published?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Eur J Cardiothorac Surg.27:910–6 published?. ### Response: 2005.


Instruction: What is one of the AHA Scientific Statements?

Output: yacute coronary syndromes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the AHA Scientific Statements?. ### Response: yacute coronary syndromes.


Instruction: When did yultrasounde730 circulate?

Output: December 6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did yultrasounde730 circulate?. ### Response: December 6.


Instruction: When was the download completed?

Output: December 6, 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the download completed?. ### Response: December 6, 2011.


Instruction: What are antagonist oral anticoagulants used for in the cardioversion of patients with atrial fibrillation?

Output: prevention of thromboembolic complications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are antagonist oral anticoagulants used for in the cardioversion of patients with atrial fibrillation?. ### Response: prevention of thromboembolic complications.


Instruction: What is the name of the systematic review and meta-analysis of antagonist oralanticoagulants?

Output: Clin ResCardiol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta-analysis of antagonist oralanticoagulants?. ### Response: Clin ResCardiol.


Instruction: How is enoxaparin compared to unfractionated heparin?

Output: Safety and ef ﬁcacy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is enoxaparin compared to unfractionated heparin?. ### Response: Safety and ef ﬁcacy.


Instruction: What is the name of the randomized multicentre study that compares enoxaparin and unfractionated heparin for short-term antithrombotic therapy?

Output: ACUTE) II

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomized multicentre study that compares enoxaparin and unfractionated heparin for short-term antithrombotic therapy?. ### Response: ACUTE) II.


Instruction: What is ACUTE?

Output: Assessment of Cardioversion Using TransoesophagealEchocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ACUTE?. ### Response: Assessment of Cardioversion Using TransoesophagealEchocardiography.


Instruction: What is the name of the multicentre study?

Output: ACUTE) II

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multicentre study?. ### Response: ACUTE) II.


Instruction: What does EurHeart J 27(23):2858-2865 mean?

Output: .253

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does EurHeart J 27(23):2858-2865 mean?. ### Response: .253.


Instruction: How long does it take to follow up pre- and post-cardioversion transesophagealechocardiography?

Output: 1-year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take to follow up pre- and post-cardioversion transesophagealechocardiography?. ### Response: 1-year.


Instruction: What is the name of the study that evaluated the safety of expeditedanticoagulation in patients undergoing transesophagealechocardiographic-guided cardioversion?

Output: Anticoagulationin Cardioversion using Enoxaparin (ACE) trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that evaluated the safety of expeditedanticoagulation in patients undergoing transesophagealechocardiographic-guided cardioversion?. ### Response: Anticoagulationin Cardioversion using Enoxaparin (ACE) trial.


Instruction: What are the names of the studies that examined the safety and efficacy ofenoxaparin compared with unfractionated heparin and oralanticoagulants for prevention of cardiovascular disease?

Output: Stellbrink C, Nixdorff U, Hofmann T, et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the studies that examined the safety and efficacy ofenoxaparin compared with unfractionated heparin and oralanticoagulants for prevention of cardiovascular disease?. ### Response: Stellbrink C, Nixdorff U, Hofmann T, et al.


Instruction: What is the name of the ACE trial?

Output: Anticoagulationin Cardioversion using Enoxaparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the ACE trial?. ### Response: Anticoagulationin Cardioversion using Enoxaparin.


Instruction: What does ACE stand for?

Output: Anticoagulationin Cardioversion using Enoxaparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ACE stand for?. ### Response: Anticoagulationin Cardioversion using Enoxaparin.


Instruction: What is the prevalence of left atrial thrombus in patients with non-valvular atrial fibrillation?

Output: Prevalence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the prevalence of left atrial thrombus in patients with non-valvular atrial fibrillation?. ### Response: Prevalence.


Instruction: What is mandatory in patients undergoing ablation ofatrialfibrillation with uninterrupted novel oral anticoagulants?

Output: transesophagealechocardiogram

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is mandatory in patients undergoing ablation ofatrialfibrillation with uninterrupted novel oral anticoagulants?. ### Response: transesophagealechocardiogram.


Instruction: What is the clinical value of left atrialappendage flow for prediction of long-term sinus rhythmmaintenance in patients with nonvalvular atrial fibrillation?

Output: Prevalence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the clinical value of left atrialappendage flow for prediction of long-term sinus rhythmmaintenance in patients with nonvalvular atrial fibrillation?. ### Response: Prevalence.


Instruction: When did JA mColl Cardiol. 2002;39(9):1443-1449?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did JA mColl Cardiol. 2002;39(9):1443-1449?. ### Response: 2002.


Instruction: What type of cardioversion is used for atrial fibrillation?

Output: Electrical

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of cardioversion is used for atrial fibrillation?. ### Response: Electrical.


Instruction: What is the name of the reanalysis of factors predicting maintenance of sinusrhythm after direct current cardioversion?

Output: ﬂutter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the reanalysis of factors predicting maintenance of sinusrhythm after direct current cardioversion?. ### Response: ﬂutter.


Instruction: What is the name of the reanalysis of atrial fibrillation and flutter?

Output: a reanalysis with recently acquired data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the reanalysis of atrial fibrillation and flutter?. ### Response: a reanalysis with recently acquired data.


Instruction: What was the result of the study?

Output: 1-year follow-up

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the result of the study?. ### Response: 1-year follow-up.


Instruction: When did cardiology issue 87(3):181-188?

Output: 1996

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did cardiology issue 87(3):181-188?. ### Response: 1996.


Instruction: What is Ranolazine an antianginal medication with minimal effects on heart rate and BP?

Output: Ranolazine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Ranolazine an antianginal medication with minimal effects on heart rate and BP?. ### Response: Ranolazine.


Instruction: What is the name of the guideline for AHA/ACC NSTE-ACS e3634.1.2.5?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the guideline for AHA/ACC NSTE-ACS e3634.1.2.5?. ### Response: 2014.


Instruction: What is ranolazine currently indicated for?

Output: treatment of chronic angina

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ranolazine currently indicated for?. ### Response: treatment of chronic angina.


Instruction: What is the MERLIN-TIMI?

Output: 36 trial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the MERLIN-TIMI?. ### Response: 36 trial.


Instruction: How many patients with NSTE-ACS were in the merin-timi trial?

Output: 6560

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with NSTE-ACS were in the merin-timi trial?. ### Response: 6560.


Instruction: How many patients with NSTE-ACS were treated with ranolazine?

Output: 6560

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with NSTE-ACS were treated with ranolazine?. ### Response: 6560.


Instruction: How long after ischemic symptoms did the patient receive the drug?

Output: 48 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after ischemic symptoms did the patient receive the drug?. ### Response: 48 hours.


Instruction: What was the primary endpoint of the post hoc analysis in women?

Output: cardiovascular death, MI, or recurrent ischemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary endpoint of the post hoc analysis in women?. ### Response: cardiovascular death, MI, or recurrent ischemia.


Instruction: Why was ranola-zine associated with a lower primary composite endpoint?

Output: a significant reduction of worsening angina, and increased exercise duration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was ranola-zine associated with a lower primary composite endpoint?. ### Response: a significant reduction of worsening angina, and increased exercise duration.


Instruction: What was the primary endpoint of the original MERLIN-TIMI 36 trial?

Output: cardiovascular death, MI, or recurrent ischemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary endpoint of the original MERLIN-TIMI 36 trial?. ### Response: cardiovascular death, MI, or recurrent ischemia.


Instruction: What was not met in the original MERLIN-TIMI 36 trial?

Output: the primary endpoint

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not met in the original MERLIN-TIMI 36 trial?. ### Response: the primary endpoint.


Instruction: What is the recommended initial dose of Ranolazine?

Output: 500 mg orally twice daily

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the recommended initial dose of Ranolazine?. ### Response: 500 mg orally twice daily.


Instruction: How many mg is recommended orally twice daily?

Output: 1000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mg is recommended orally twice daily?. ### Response: 1000.


Instruction: What are some of the major adverse effects of ranolazine?

Output: constipation, nausea, dizziness, and headache

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some of the major adverse effects of ranolazine?. ### Response: constipation, nausea, dizziness, and headache.


Instruction: What is the main adverse effect of running azine on the body?

Output: constipation, nausea, dizziness, and headache

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the main adverse effect of running azine on the body?. ### Response: constipation, nausea, dizziness, and headache.


Instruction: In what trial was the QTc prolongation requiring dose reduction comparable?

Output: MERLIN-TIMI 36

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what trial was the QTc prolongation requiring dose reduction comparable?. ### Response: MERLIN-TIMI 36.


Instruction: What is IABP counterpulsation used for?

Output: refractory ischemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is IABP counterpulsation used for?. ### Response: refractory ischemia.


Instruction: What is used to treat severe persistent or recurrent ischemia?

Output: Intra-Aortic Balloon Pump

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used to treat severe persistent or recurrent ischemia?. ### Response: Intra-Aortic Balloon Pump.


Instruction: In experimental studies, what increases diastolic BP?

Output: IABP counterpulsation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In experimental studies, what increases diastolic BP?. ### Response: IABP counterpulsation.


Instruction: What increases diastolic BP and coronary blood flow?

Output: IABP counterpulsation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What increases diastolic BP and coronary blood flow?. ### Response: IABP counterpulsation.


Instruction: What does IABP counterpulsation do?

Output: increases diastolic BP and coronary blood flow and potentially augments cardiac output while diminishing LV end-diastolic pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does IABP counterpulsation do?. ### Response: increases diastolic BP and coronary blood flow and potentially augments cardiac output while diminishing LV end-diastolic pressure.


Instruction: How long has the use of IAB for refractory ischemia been around?

Output: several decades

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long has the use of IAB for refractory ischemia been around?. ### Response: several decades.


Instruction: What type of studies are primarily driven by clinical experi-ence and nonrandomized observational studies?

Output: experimental studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of studies are primarily driven by clinical experi-ence and nonrandomized observational studies?. ### Response: experimental studies.


Instruction: What failed to reduce MACE in high-risk elective PCI?

Output: IABP counterpulsation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What failed to reduce MACE in high-risk elective PCI?. ### Response: IABP counterpulsation.


Instruction: How did IABP counterpulsation decrease infarct size after primary PCI for acute STEMI??

Output: failed to reduce MACE in high-risk elective PCI,266

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did IABP counterpulsation decrease infarct size after primary PCI for acute STEMI??. ### Response: failed to reduce MACE in high-risk elective PCI,266.


Instruction: What is Cholesterol ManagementClass I1?

Output: High-intensity statin therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Cholesterol ManagementClass I1?. ### Response: High-intensity statin therapy.


Instruction: What type of shock complicates AMI?

Output: cardiogenic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of shock complicates AMI?. ### Response: cardiogenic.


Instruction: Cholesterol ManagementClass I1. High-intensity statin therapy should be initiated or continued in all patients with what?

Output: NSTE-ACS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Cholesterol ManagementClass I1. High-intensity statin therapy should be initiated or continued in all patients with what?. ### Response: NSTE-ACS.


Instruction: What do these trials use?

Output: fixed doses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do these trials use?. ### Response: fixed doses.


Instruction: What could potentially be used to inform management decisions and optimise treatment?

Output: measurement of biomarkers and imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could potentially be used to inform management decisions and optimise treatment?. ### Response: measurement of biomarkers and imaging.


Instruction: What was the aim of this review?

Output: to examine the clinical and cost -effectiveness of biomarker measurement or imaging in the management of patients with HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the aim of this review?. ### Response: to examine the clinical and cost -effectiveness of biomarker measurement or imaging in the management of patients with HF.


Instruction: What did this review examine in the management of patients with HF?

Output: the clinical and cost -effectiveness of biomarker measurement or imaging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did this review examine in the management of patients with HF?. ### Response: the clinical and cost -effectiveness of biomarker measurement or imaging.


Instruction: What is an important component of management in patients with long QT syndrome type 2?

Output: GUIDELINESthat promote depletion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an important component of management in patients with long QT syndrome type 2?. ### Response: GUIDELINESthat promote depletion.


Instruction: What should be reduced with antipyretics?

Output: fever

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be reduced with antipyretics?. ### Response: fever.


Instruction: Where are references that support the recommendations summarized?

Output: Online Data Supplement 41.COR LOE RecommendationsI B-NR1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are references that support the recommendations summarized?. ### Response: Online Data Supplement 41.COR LOE RecommendationsI B-NR1.


Instruction: What is recommended in patients with catecholaminergic polymorphic ventricular tachycardia?

Output: a beta blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended in patients with catecholaminergic polymorphic ventricular tachycardia?. ### Response: a beta blocker.


Instruction: What type of ventricular tachycardia is a beta blocker recommended for?

Output: catecholaminergic polymorphic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of ventricular tachycardia is a beta blocker recommended for?. ### Response: catecholaminergic polymorphic.


Instruction: What is recommended in patients with catecholaminergic polymorphic ventricular Tachycardie?

Output: a beta blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended in patients with catecholaminergic polymorphic ventricular Tachycardie?. ### Response: a beta blocker.


Instruction: In patients with recurrent sustained sustained VT or syncope, what type of treatment is recommended?

Output: combination medication therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with recurrent sustained sustained VT or syncope, what type of treatment is recommended?. ### Response: combination medication therapy.


Instruction: What is recommended in patients with catecholaminergic polymorphic ventricular tachycardia and with clinical VT or exertional syncope?

Output: genetic counseling and genetic testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is recommended in patients with catecholaminergic polymorphic ventricular tachycardia and with clinical VT or exertional syncope?. ### Response: genetic counseling and genetic testing.


Instruction: What is characterized by exertion-related poly-morphic or bidirectional VT?

Output: Catecholaminergic polymorphic ventricular tachy-cardia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is characterized by exertion-related poly-morphic or bidirectional VT?. ### Response: Catecholaminergic polymorphic ventricular tachy-cardia.


Instruction: What is associated with syncope and SCA?

Output: exertion-related poly-morphic or bidirectional VT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with syncope and SCA?. ### Response: exertion-related poly-morphic or bidirectional VT.


Instruction: SCA/SCD is reported in what percentage of patients?

Output: 3% to 13%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: SCA/SCD is reported in what percentage of patients?. ### Response: 3% to 13%.


Instruction: What is the main benefit of using nadolol over other types of beta blockers?

Output: reduction in adverse cardiac events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the main benefit of using nadolol over other types of beta blockers?. ### Response: reduction in adverse cardiac events.


Instruction: What is important to use a maximally tolerated dose of a beta blocker?

Output: treatment intensification with either combination medication therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is important to use a maximally tolerated dose of a beta blocker?. ### Response: treatment intensification with either combination medication therapy.


Instruction: Small observational studies sug-gest possible benefit of nondihydropyridine calcium channel blockers in the treatment of catecholaminergic polymorphic ventricular tachycardia?

Output: S7.9.1.2-9,S7.9.1.2-102

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Small observational studies sug-gest possible benefit of nondihydropyridine calcium channel blockers in the treatment of catecholaminergic polymorphic ventricular tachycardia?. ### Response: S7.9.1.2-9,S7.9.1.2-102.


Instruction: What is a treatment for catecholaminergic polymorphic ventricular tachycardia?

Output: beta blocker

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a treatment for catecholaminergic polymorphic ventricular tachycardia?. ### Response: beta blocker.


Instruction: Flecainide in combination with a beta blocker can suppress what by as much as 76%?

Output: ventricular ectopy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Flecainide in combination with a beta blocker can suppress what by as much as 76%?. ### Response: ventricular ectopy.


Instruction: What is an effective treatment for refractory VA?

Output: verapamil or propafenone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an effective treatment for refractory VA?. ### Response: verapamil or propafenone.


Instruction: Verapamil or propafenone may be effective for what?

Output: refractory VA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Verapamil or propafenone may be effective for what?. ### Response: refractory VA.


Instruction: Verapamil or propafenone may be what?

Output: refractory VA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Verapamil or propafenone may be what?. ### Response: refractory VA.


Instruction: ICD implantation in patients with catecholaminergic polymorphic ventricular tachycardia should be reserved for patients with prior SCA or patients with refractory VAs on combination medical therapy?

Output: ICD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: ICD implantation in patients with catecholaminergic polymorphic ventricular tachycardia should be reserved for patients with prior SCA or patients with refractory VAs on combination medical therapy?. ### Response: ICD.


Instruction: In 20% to 30% of patients with ICDs with what are inappropriate shocks reported?

Output: S7.9.1.2-2,S7.9.1.2-13–S7.9.1.2-16 ICD programming

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In 20% to 30% of patients with ICDs with what are inappropriate shocks reported?. ### Response: S7.9.1.2-2,S7.9.1.2-13–S7.9.1.2-16 ICD programming.


Instruction: What percentage of catecholaminergic poly-morphic ventricular tachycardia patients have ICDs?

Output: 20% to 30%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of catecholaminergic poly-morphic ventricular tachycardia patients have ICDs?. ### Response: 20% to 30%.


Instruction: What is the name of the 2011 ACCF/AHA guideline for coronary artery bypass graft surgery?

Output: SCAI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2011 ACCF/AHA guideline for coronary artery bypass graft surgery?. ### Response: SCAI.


Instruction: What was developed in collaboration with American Association for Thoracic Surgery?

Output: Practice Guidelines. Circulation. 2012;126:1784–800. S1.4-25.  Hillis LD, Smith PK, Anderson JL, et al. 2011 ACCF/AHA guideline for coronary artery bypass graft surgery. a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was developed in collaboration with American Association for Thoracic Surgery?. ### Response: Practice Guidelines. Circulation. 2012;126:1784–800. S1.4-25.  Hillis LD, Smith PK, Anderson JL, et al. 2011 ACCF/AHA guideline for coronary artery bypass graft surgery. a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.


Instruction: Who collaborated with the American Association for Thoracic Surgery, Society of Cardiovascular Anesthesiologists, and Society of Thracic Surgeons?

Output: American College of Cardiology Foundation/American Heart Association Task Force

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who collaborated with the American Association for Thoracic Surgery, Society of Cardiovascular Anesthesiologists, and Society of Thracic Surgeons?. ### Response: American College of Cardiology Foundation/American Heart Association Task Force.


Instruction: What is the 2011 ACCF/AHA/SCAI guide-line for percutaneous coronary intervention?

Output: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2011 ACCF/AHA/SCAI guide-line for percutaneous coronary intervention?. ### Response: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions.


Instruction: The American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions.

Output: Bates ER, Blankenship JC, et al. 2011 ACCF/AHA/SCAI guide-line for percutaneous coronary intervention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions.. ### Response: Bates ER, Blankenship JC, et al. 2011 ACCF/AHA/SCAI guide-line for percutaneous coronary intervention.


Instruction: What is the name of the AHA/ACCF secondary prevention and risk reduction therapy?

Output: Smith SC Jr, Benjamin EJ, Bonow RO, et al. AHA/ACCF secondary prevention and risk reduction therapy for patients with coronary and other atherosclerotic vascular disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the AHA/ACCF secondary prevention and risk reduction therapy?. ### Response: Smith SC Jr, Benjamin EJ, Bonow RO, et al. AHA/ACCF secondary prevention and risk reduction therapy for patients with coronary and other atherosclerotic vascular disease.


Instruction: What is a guideline from the American Heart Association and American College of Cardiology Foundation for patients with coronary and other atherosclerotic vascular disease?

Output: AHA/ACCF secondary prevention and risk reduction therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a guideline from the American Heart Association and American College of Cardiology Foundation for patients with coronary and other atherosclerotic vascular disease?. ### Response: AHA/ACCF secondary prevention and risk reduction therapy.


Instruction: What is the current status and future directions of strategies to improve cardiac arrest survival?

Output: a time to act

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the current status and future directions of strategies to improve cardiac arrest survival?. ### Response: a time to act.


Instruction: What is the title of Future Directions: Strategies to improve cardiac arrest survival: a time to act?

Output: Committee on the Treatment of Cardiac Arrest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the title of Future Directions: Strategies to improve cardiac arrest survival: a time to act?. ### Response: Committee on the Treatment of Cardiac Arrest.


Instruction: Where is the publication published?

Output: National Academic Press

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the publication published?. ### Response: National Academic Press.


Instruction: What are the recommendations for competitive athletes with cardiovascular abnormalities?

Output: Eligibility and disqualifica-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the recommendations for competitive athletes with cardiovascular abnormalities?. ### Response: Eligibility and disqualifica-tion.


Instruction: What is a scientific statement from the American Heart Association and American College of Cardiology?

Output: automated external defibrilla-tors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a scientific statement from the American Heart Association and American College of Cardiology?. ### Response: automated external defibrilla-tors.


Instruction: What does EHRA/HRS/APHRS expert con-sensus on ventricular arrhythmias?

Output: Heart Rhythm

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does EHRA/HRS/APHRS expert con-sensus on ventricular arrhythmias?. ### Response: Heart Rhythm.


Instruction: What is the name of the partnership between the Pediatric and Congenital Electrophysiology Society (PACES) and the Heart Rhythm Society (HRS)?

Output: PACES/HRS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the partnership between the Pediatric and Congenital Electrophysiology Society (PACES) and the Heart Rhythm Society (HRS)?. ### Response: PACES/HRS.


Instruction: What is the acronym for the Heart Rhythm Society?

Output: HRS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the Heart Rhythm Society?. ### Response: HRS.


Instruction: What does HRS stand for?

Output: Heart Rhythm Society

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does HRS stand for?. ### Response: Heart Rhythm Society.


Instruction: How is implantable cardioverter-defibril-lator therapy used?

Output: patients who are not included or not well repre-sented in clinical trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is implantable cardioverter-defibril-lator therapy used?. ### Response: patients who are not included or not well repre-sented in clinical trials.


Instruction: Who is the HRS expert consensus statement?

Output: Priori SG, Wilde AA, Horie M, et al. HRS/EHRA/APHRS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the HRS expert consensus statement?. ### Response: Priori SG, Wilde AA, Horie M, et al. HRS/EHRA/APHRS.


Instruction: In what year did Circulation issue 130:94–125?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did Circulation issue 130:94–125?. ### Response: 2014.


Instruction: What year did Heart Rhythm issue 11:1305–23?

Output: 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Heart Rhythm issue 11:1305–23?. ### Response: 2014.


Instruction: Who wrote the HRS/EHRA/APHRS expert consensus state-ment on the diagnosis and management of arrhythmias associated with cardiac sarcoidosis?

Output: Birnie DH

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote the HRS/EHRA/APHRS expert consensus state-ment on the diagnosis and management of arrhythmias associated with cardiac sarcoidosis?. ### Response: Birnie DH.


Instruction: What does HRS/EHRA/APHRS expert con-sensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes address?

Output: the diagnosis and management of arrhythmias associated with cardiac sarcoidosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does HRS/EHRA/APHRS expert con-sensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes address?. ### Response: the diagnosis and management of arrhythmias associated with cardiac sarcoidosis.


Instruction: What does EPIDEMIOLOGY do?

Output: recognition and management of arrhyth-mias in adult congenital heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does EPIDEMIOLOGY do?. ### Response: recognition and management of arrhyth-mias in adult congenital heart disease.


Instruction: When did MHRA add a footnot e to the recommendations 1.4.11 and 1.4.12?

Output: August 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did MHRA add a footnot e to the recommendations 1.4.11 and 1.4.12?. ### Response: August 2016.


Instruction: When was ivabradine added?

Output: June 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was ivabradine added?. ### Response: June 2014.


Instruction: When was ivabradine published?

Output: June 2014

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was ivabradine published?. ### Response: June 2014.


Instruction: When did nicorandil come out?

Output: Januar y 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did nicorandil come out?. ### Response: Januar y 2016.


Instruction: What was updat ed since publication in December 2012?

Output: The licensing inf ormation f or nicorandil

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was updat ed since publication in December 2012?. ### Response: The licensing inf ormation f or nicorandil.


Instruction: Accreditation Stable angina: management (CG126) NICE 2022. Subject t o Notice of right s (http://www.nice.org.uk/t erms-and-conditions#notice-of-right s)

Output: All right s reserved

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Accreditation Stable angina: management (CG126) NICE 2022. Subject t o Notice of right s (http://www.nice.org.uk/t erms-and-conditions#notice-of-right s). ### Response: All right s reserved.


Instruction: What does the Action to Control Cardiovascular Risk in Diabetes Study Group do?

Output: Effects of intensive glu-cose lowering in type 2 diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the Action to Control Cardiovascular Risk in Diabetes Study Group do?. ### Response: Effects of intensive glu-cose lowering in type 2 diabetes.


Instruction: What is the effect of intensive glu-cose lowering in type 2 diabetes?

Output: Effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of intensive glu-cose lowering in type 2 diabetes?. ### Response: Effects.


Instruction: When was N Engl J Med 358:2545-2559?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was N Engl J Med 358:2545-2559?. ### Response: 2008.


Instruction: What is type 2 diabetes?

Output: mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is type 2 diabetes?. ### Response: mellitus.


Instruction: When did N Engl J Med issue 358:2545–2559?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did N Engl J Med issue 358:2545–2559?. ### Response: 2008.


Instruction: What is the name of the study that investigated intensive diabetes treatment and cardiovascular disease in patients?

Output: Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated intensive diabetes treatment and cardiovascular disease in patients?. ### Response: Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group.


Instruction: What is the name of the research group that studies Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes?

Output: Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the research group that studies Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes?. ### Response: Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group.


Instruction: When did the N Engl J Med issue 353:2643–2653?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the N Engl J Med issue 353:2643–2653?. ### Response: 2005.


Instruction: What is a systematic review of?

Output: glucose control and cardiovascular disease in type 2 diabetes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a systematic review of?. ### Response: glucose control and cardiovascular disease in type 2 diabetes.


Instruction: What is the name of the disease that affects type 2 diabetes?

Output: mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease that affects type 2 diabetes?. ### Response: mellitus.


Instruction: How many people died from diabetes mellitus in 2009?

Output: 244

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people died from diabetes mellitus in 2009?. ### Response: 244.


Instruction: What did intensive control of glucose do for diabetes patients?

Output: lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did intensive control of glucose do for diabetes patients?. ### Response: lowering.


Instruction: What is a meta-anal-ysis of randomised controlled trials in patients with diabetes mellitus?

Output: Effect of intensive control of glucose on cardiovas-cular outcomes and death

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a meta-anal-ysis of randomised controlled trials in patients with diabetes mellitus?. ### Response: Effect of intensive control of glucose on cardiovas-cular outcomes and death.


Instruction: What is the Lancet. 2009;373:1765–1772.

Output: a meta-anal-ysis of randomised controlled trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Lancet. 2009;373:1765–1772.. ### Response: a meta-anal-ysis of randomised controlled trials.


Instruction: What does Pioglitazone for diabetes prevention in impaired glucose tolerance?

Output: ACT NOW Study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Pioglitazone for diabetes prevention in impaired glucose tolerance?. ### Response: ACT NOW Study.


Instruction: What drug is used for diabetes prevention in impaired glucose tolerance?

Output: Pioglitazone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug is used for diabetes prevention in impaired glucose tolerance?. ### Response: Pioglitazone.


Instruction: What is the name of the randomised trial of acarbose?

Output: STOP-NIDDM

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised trial of acarbose?. ### Response: STOP-NIDDM.


Instruction: When was the STOP-NIDDM trial conducted?

Output: 2002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the STOP-NIDDM trial conducted?. ### Response: 2002.


Instruction: What is the STOP-NIDDM randomised trial?

Output: Acarbose for prevention of type 2 diabetes mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the STOP-NIDDM randomised trial?. ### Response: Acarbose for prevention of type 2 diabetes mellitus.


Instruction: What is liraglutide versus placebo for?

Output: type 2 diabetes risk reduction and weight management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is liraglutide versus placebo for?. ### Response: type 2 diabetes risk reduction and weight management.


Instruction: What is liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes?

Output: 3 Y ears

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes?. ### Response: 3 Y ears.


Instruction: What is the name of the randomised, double-blind trial?

Output: NN8022-1839 Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the randomised, double-blind trial?. ### Response: NN8022-1839 Study Group.


Instruction: What is the name of the IRIS Trial Investigators?

Output: Kernan WN

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the IRIS Trial Investigators?. ### Response: Kernan WN.


Instruction: What is Pioglitazone after after ischemic stroke or transient ischemia?

Output: impaired glucose tolerance

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Pioglitazone after after ischemic stroke or transient ischemia?. ### Response: impaired glucose tolerance.


Instruction: When was the N Engl J Med.374:1321-1331?

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the N Engl J Med.374:1321-1331?. ### Response: 2016.


Instruction: What is the ef-fect of type 2 diabetes mellitus on ischemic heart disease?

Output: independent

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ef-fect of type 2 diabetes mellitus on ischemic heart disease?. ### Response: independent.


Instruction: What is type 2 diabetes mellitus' effect on ischemic heart disease, stroke, and death?

Output: independent ef-fect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is type 2 diabetes mellitus' effect on ischemic heart disease, stroke, and death?. ### Response: independent ef-fect.


Instruction: How many people were enrolled in a population-based study?

Output: 13,000

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people were enrolled in a population-based study?. ### Response: 13,000.


Instruction: What are incredibly benefi-cial to patients?

Output: financial support and financial services

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are incredibly benefi-cial to patients?. ### Response: financial support and financial services.


Instruction: Why may some patients skip a doctor's appointment?

Output: to pay a residential utility bill

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why may some patients skip a doctor's appointment?. ### Response: to pay a residential utility bill.


Instruction: What are some different BP Thresholds and Goals for Pharmacological Therapy?

Output: 120/80 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are some different BP Thresholds and Goals for Pharmacological Therapy?. ### Response: 120/80 mm Hg.


Instruction: What are BP thresholds and goals for the long-term treatment of hypertension with pharmacological therapy recommended in this guideline?

Output: <120/80 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are BP thresholds and goals for the long-term treatment of hypertension with pharmacological therapy recommended in this guideline?. ### Response: <120/80 mm Hg.


Instruction: What are the patients in general and for those with specific comorbidi-ties in Table 23.15?

Output: hyperten-sive

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the patients in general and for those with specific comorbidi-ties in Table 23.15?. ### Response: hyperten-sive.


Instruction: What did the writing committee call on to make strong recommendations across a broad range of medical conditions?

Output: the large body of literature on BP and hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the writing committee call on to make strong recommendations across a broad range of medical conditions?. ### Response: the large body of literature on BP and hypertension.


Instruction: What are recommendations across a broad range of medical con-ditions?

Output: strong

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are recommendations across a broad range of medical con-ditions?. ### Response: strong.


Instruction: Where are significant gaps in knowledge?

Output: there are areas where epidemiological and natural history studies suggest that hypertension prevention or earlier treatment of hypertension might substantially improve outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where are significant gaps in knowledge?. ### Response: there are areas where epidemiological and natural history studies suggest that hypertension prevention or earlier treatment of hypertension might substantially improve outcomes.


Instruction: What are lacking to provide guidance?

Output: clinical trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are lacking to provide guidance?. ### Response: clinical trials.


Instruction: What is lacking to provide guidance?

Output: clinical trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is lacking to provide guidance?. ### Response: clinical trials.


Instruction: What shows a graded relationship between BP and outcomes?

Output: epidemiological data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What shows a graded relationship between BP and outcomes?. ### Response: epidemiological data.


Instruction: The results of the SPRINT trial show benefit of more comprehensive treatment to a target BP of 120/80 mm Hg.

Output: significant gaps in knowledge exist.Importantly, there are areas where epidemiological and natural history studies suggest that hypertension prevention or earlier treatment of hypertension might substantially improve outcomes, but clinical trials are lacking to provide guidance. The combination of epidemiological data showing a graded relationship between BP and outcomes, particularly above a BP of 120/80 mm Hg, and the results of the SPRINT trial showing benefit of more comprehensive treatment to a target BP of <120/80 mm Hg, suggests that a lifelong BP below that level will substantially lower CVD and CKD incidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The results of the SPRINT trial show benefit of more comprehensive treatment to a target BP of 120/80 mm Hg.. ### Response: significant gaps in knowledge exist.Importantly, there are areas where epidemiological and natural history studies suggest that hypertension prevention or earlier treatment of hypertension might substantially improve outcomes, but clinical trials are lacking to provide guidance. The combination of epidemiological data showing a graded relationship between BP and outcomes, particularly above a BP of 120/80 mm Hg, and the results of the SPRINT trial showing benefit of more comprehensive treatment to a target BP of <120/80 mm Hg, suggests that a lifelong BP below that level will substantially lower CVD and CKD incidence.


Instruction: What is the target BP for CVD and CKD?

Output: <120/80 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the target BP for CVD and CKD?. ### Response: <120/80 mm Hg.


Instruction: What does a lifelong BP below 120/80 mm Hg suggest?

Output: substantially lower CVD and CKD incidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does a lifelong BP below 120/80 mm Hg suggest?. ### Response: substantially lower CVD and CKD incidence.


Instruction: Younger individuals, those with DM, and those with high lifetime CVD risk are particularly at risk for what?

Output: mortality or CVD events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Younger individuals, those with DM, and those with high lifetime CVD risk are particularly at risk for what?. ### Response: mortality or CVD events.


Instruction: On the presence of multiple risk factors, including high BP, what is one risk factor?

Output: high lifetime CVD risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On the presence of multiple risk factors, including high BP, what is one risk factor?. ### Response: high lifetime CVD risk.


Instruction: If hard, cardiovascular outcome clinical trials remain the sole driver of evidence-based guidelines, what may not be possible?

Output: determining the full benefit of earlier interven-tion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: If hard, cardiovascular outcome clinical trials remain the sole driver of evidence-based guidelines, what may not be possible?. ### Response: determining the full benefit of earlier interven-tion.


Instruction: What may be different if antihy-pertensive treatment is initiated earlier in the natural history of CVD?

Output: Outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be different if antihy-pertensive treatment is initiated earlier in the natural history of CVD?. ### Response: Outcomes.


Instruction: DM may provide a population in whom to test this hypothesis?

Output: younger individuals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: DM may provide a population in whom to test this hypothesis?. ### Response: younger individuals.


Instruction: What type of outcomes include both prevention of events and surrogates?

Output: Composite outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of outcomes include both prevention of events and surrogates?. ### Response: Composite outcomes.


Instruction: What should be considered in order to prevent decline in renal function?

Output: Composite outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be considered in order to prevent decline in renal function?. ### Response: Composite outcomes.


Instruction: What is an example of a surrogate that should be taken into consideration?

Output: prevention of decline in renal function or amelioration of measures of subclinical atheroscle-rosis, vascular stiffness, or LV structure and function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a surrogate that should be taken into consideration?. ### Response: prevention of decline in renal function or amelioration of measures of subclinical atheroscle-rosis, vascular stiffness, or LV structure and function.


Instruction: What is highly desirable in younger patients with DM and in countries where nonischemic stroke is the predominant cause of CVD?

Output: Replication of SPRINT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is highly desirable in younger patients with DM and in countries where nonischemic stroke is the predominant cause of CVD?. ### Response: Replication of SPRINT.


Instruction: What is needed to demonstrate the practicality of SPRINT-like interventions in resource-constrained practice settings?

Output: implementation studies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is needed to demonstrate the practicality of SPRINT-like interventions in resource-constrained practice settings?. ### Response: implementation studies.


Instruction: What is urgently needed relating hypertensive?

Output: More information

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is urgently needed relating hypertensive?. ### Response: More information.


Instruction: What is the effect of ampicillin plus ceftriaxone on experimental endocarditis?

Output: Efficacy of ampicillin plus ceftriaxone in treatment of experimental endocarditis due to Enterococcus faecalis strains highly resistant to aminoglycosides

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of ampicillin plus ceftriaxone on experimental endocarditis?. ### Response: Efficacy of ampicillin plus ceftriaxone in treatment of experimental endocarditis due to Enterococcus faecalis strains highly resistant to aminoglycosides.


Instruction: What are Enterococcus faecalis strains highly resistant to?

Output: aminoglycosides

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are Enterococcus faecalis strains highly resistant to?. ### Response: aminoglycosides.


Instruction: When did Antimicrob Agents Chemother issue 43:639-646?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Antimicrob Agents Chemother issue 43:639-646?. ### Response: 1999.


Instruction: How did Arias CA, Contreras GA, Murray BE manage multidrug-resistant enterococcal infections?

Output: combination tigecycline and high-dose daptomycin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did Arias CA, Contreras GA, Murray BE manage multidrug-resistant enterococcal infections?. ### Response: combination tigecycline and high-dose daptomycin.


Instruction: What year was the outbreak of linezolid-resistant enterococci?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the outbreak of linezolid-resistant enterococci?. ### Response: 2007.


Instruction: What year did Emerg Infect Dis. 2007:13:1024-1030?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Emerg Infect Dis. 2007:13:1024-1030?. ### Response: 2007.


Instruction: What drug is used for the treatment of multidrug-resistant, gram-positive infections?

Output: Linezolid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug is used for the treatment of multidrug-resistant, gram-positive infections?. ### Response: Linezolid.


Instruction: What is the name of the program that provides Linezolid?

Output: compassionate-use program

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the program that provides Linezolid?. ### Response: compassionate-use program.


Instruction: When did Clin Infect Dis 2003 issue 36:159–168?

Output: 2003

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Clin Infect Dis 2003 issue 36:159–168?. ### Response: 2003.


Instruction: What drug is as effective as daptomycin?

Output: linezolid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What drug is as effective as daptomycin?. ### Response: linezolid.


Instruction: What is the effect of linezolid on bacteraemia?

Output: outbreak of linezolid-resistant enterococci

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of linezolid on bacteraemia?. ### Response: outbreak of linezolid-resistant enterococci.


Instruction: When did the J Antimicrob Chemother issue 64:175-181. doi: 10.1093/jac/dkp154?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the J Antimicrob Chemother issue 64:175-181. doi: 10.1093/jac/dkp154?. ### Response: 2009.


Instruction: How was the treatment of vancomycin-resistant enterococcus endo-carditis?

Output: Successful treatment of vancomycin-resistant enterococcus endo-carditis with oral linezolid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the treatment of vancomycin-resistant enterococcus endo-carditis?. ### Response: Successful treatment of vancomycin-resistant enterococcus endo-carditis with oral linezolid.


Instruction: What is the name of the drug used to treat prosthetic valve infective endocarditis due to multi-resistant Gram-positive bacteria?

Output: linezolid

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the drug used to treat prosthetic valve infective endocarditis due to multi-resistant Gram-positive bacteria?. ### Response: linezolid.


Instruction: What year did J Infect. 2006:52:300-304?

Output: 2005

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did J Infect. 2006:52:300-304?. ### Response: 2005.


Instruction: What type of endocarditis is Vancomycin-resistant Enterococcus faecalis?

Output: Infective

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of endocarditis is Vancomycin-resistant Enterococcus faecalis?. ### Response: Infective.


Instruction: What is the name of the journal that describes the characterization of virulence factors?

Output: J Clin Microbiol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that describes the characterization of virulence factors?. ### Response: J Clin Microbiol.


Instruction: How is Daptomycin resistance determined in Enterococcius Faecalis?

Output: linezolid fail-ure and strain characterization of virulence factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is Daptomycin resistance determined in Enterococcius Faecalis?. ### Response: linezolid fail-ure and strain characterization of virulence factors.


Instruction: When was the J Antimicrob Chemother published?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Antimicrob Chemother published?. ### Response: 2008.


Instruction: What is a prosthetic valve endocarditis?

Output: infective endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a prosthetic valve endocarditis?. ### Response: infective endocarditis.


Instruction: What is the name of the journal that studies the use of daptomycin in the treatment of patients with infec-tive endocrine disease?

Output: Ann Pharmacother.

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that studies the use of daptomycin in the treatment of patients with infec-tive endocrine disease?. ### Response: Ann Pharmacother..


Instruction: When did Am J Med issue 120(suppl 1):S28–S33?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Am J Med issue 120(suppl 1):S28–S33?. ### Response: 2007.


Instruction: How many patients were treated with daptomycin for gram-positive bacteremia and infective endocarditis?

Output: 31

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with daptomycin for gram-positive bacteremia and infective endocarditis?. ### Response: 31.


Instruction: What is the name of the retrospective case series of 31 patients?

Output: ocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the retrospective case series of 31 patients?. ### Response: ocarditis.


Instruction: When did Pharmacotherapy. 2006:26:347–352. doi: 10.1592/phco.26.3.347.

Output: 2006

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Pharmacotherapy. 2006:26:347–352. doi: 10.1592/phco.26.3.347.. ### Response: 2006.


Instruction: What was a case report of?

Output: Infective endocarditis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a case report of?. ### Response: Infective endocarditis.


Instruction: What year did Scand J Infect Dis publish?

Output: 2007

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Scand J Infect Dis publish?. ### Response: 2007.


Instruction: What is the name of the 2007 study that investigated multidrug-resistant Enterococcus faecium endo-carditis treated with combination tigecycline and high-dose daptomycin?

Output: J Clin Microbiol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2007 study that investigated multidrug-resistant Enterococcus faecium endo-carditis treated with combination tigecycline and high-dose daptomycin?. ### Response: J Clin Microbiol.


Instruction: What percentage of cardiacsurgery patients have nosocomial infections?

Output: 10% to 20%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of cardiacsurgery patients have nosocomial infections?. ### Response: 10% to 20%.


Instruction: To prevent surgical site infections in CABGpatients, a multimodality approach involving several periop-Hillis et al 2011 ACCF/AHA CABG Guideline e689Downloaded from http://ahajournals.org by on what date?

Output: April 26, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: To prevent surgical site infections in CABGpatients, a multimodality approach involving several periop-Hillis et al 2011 ACCF/AHA CABG Guideline e689Downloaded from http://ahajournals.org by on what date?. ### Response: April 26, 2023.


Instruction: What is the name of the 2017 VA/SCD GuidelineCirculation study?

Output: Al-Khatib et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2017 VA/SCD GuidelineCirculation study?. ### Response: Al-Khatib et al.


Instruction: What are the names of the authors of the 2018 VA and SCD guideline?

Output: Antzelevitch C, Yan GX, Ackerman MJ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the authors of the 2018 VA and SCD guideline?. ### Response: Antzelevitch C, Yan GX, Ackerman MJ.


Instruction: When was the J-wave syndromes expert consensus conference report published?

Output: 2011

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J-wave syndromes expert consensus conference report published?. ### Response: 2011.


Instruction: What is a risk stratification in individuals with the Brugada type 1 ECG pattern without previous cardiac arrest?

Output: usefulness of a combined clinical and electrophysiologic approach

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk stratification in individuals with the Brugada type 1 ECG pattern without previous cardiac arrest?. ### Response: usefulness of a combined clinical and electrophysiologic approach.


Instruction: What is the use of a combined clinical and electrophysiologic approach?

Output: Risk stratification in individuals with the Brugada type 1 ECG pattern without previous cardiac arrest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the use of a combined clinical and electrophysiologic approach?. ### Response: Risk stratification in individuals with the Brugada type 1 ECG pattern without previous cardiac arrest.


Instruction: What does CASPER stand for?

Output: Cardiac Arrest Survivors with Preserved Ejection Fraction Registry

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does CASPER stand for?. ### Response: Cardiac Arrest Survivors with Preserved Ejection Fraction Registry.


Instruction: What is the name of the systematic review for the 2017 AHA/ACC/HRS guideline?

Output: S7.9.1.3-15

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review for the 2017 AHA/ACC/HRS guideline?. ### Response: S7.9.1.3-15.


Instruction: What is the 2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death?

Output: Systematic review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the 2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death?. ### Response: Systematic review.


Instruction: What was the report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines?

Output: Systematic review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines?. ### Response: Systematic review.


Instruction: What is asymptomatic Brugada syn-drome?

Output: clinical characterization and long-term prognosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is asymptomatic Brugada syn-drome?. ### Response: clinical characterization and long-term prognosis.


Instruction: What is the prognostic value of pro-grammed electrical stimulation in Brugadas syndrome?

Output: 20 years experience

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the prognostic value of pro-grammed electrical stimulation in Brugadas syndrome?. ### Response: 20 years experience.


Instruction: How long has Sieira J, Ciconte G, and Conte G had experience with Brugades?

Output: 20 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long has Sieira J, Ciconte G, and Conte G had experience with Brugades?. ### Response: 20 years.


Instruction: How many years of experience have patients with Brugada syndrome had?

Output: 20

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many years of experience have patients with Brugada syndrome had?. ### Response: 20.


Instruction: What are the implications for genetic testing in a cohort of unrelated patients?

Output: Spectrum and prevalence of mutations involving BrS1- through BrS12-susceptibility genes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the implications for genetic testing in a cohort of unrelated patients?. ### Response: Spectrum and prevalence of mutations involving BrS1- through BrS12-susceptibility genes.


Instruction: Which gene is involved in the spectrum and prevalence of mutations?

Output: BrS1- through BrS12-susceptibility

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which gene is involved in the spectrum and prevalence of mutations?. ### Response: BrS1- through BrS12-susceptibility.


Instruction: What are implications for genetic testing?

Output: Spectrum and prevalence of mutations involving BrS1- through BrS12-susceptibility genes in a cohort of unrelated patients referred for Brugada syndrome genetic testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are implications for genetic testing?. ### Response: Spectrum and prevalence of mutations involving BrS1- through BrS12-susceptibility genes in a cohort of unrelated patients referred for Brugada syndrome genetic testing.


Instruction: What mutations and the role of genetic background in the pathophysiology of Brugada syn-drome?

Output: SCN5A

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What mutations and the role of genetic background in the pathophysiology of Brugada syn-drome?. ### Response: SCN5A.


Instruction: What is the high prevalence of genetic variants previously associated with Brugada syndrome in new exome data?

Output: S7.9.1.3-21.  Brugada drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the high prevalence of genetic variants previously associated with Brugada syndrome in new exome data?. ### Response: S7.9.1.3-21.  Brugada drugs.


Instruction: What is available at: http://www.brugadadrugs.org?

Output: Brugada drugs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is available at: http://www.brugadadrugs.org?. ### Response: Brugada drugs.


Instruction: What is the name of the website that provides information on drugs and Brugada syn-drome patients?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the website that provides information on drugs and Brugada syn-drome patients?. ### Response: www.brugadadrugs.org.


Instruction: When did Heart Rhythm. 2009:6:1335–41. When did Behr ER, Denjoy I, and Andorin A, Behr E, et al. study the impact of clinical and genetic findings on the management of young patients with Brugadasyndrom?

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Heart Rhythm. 2009:6:1335–41. When did Behr ER, Denjoy I, and Andorin A, Behr E, et al. study the impact of clinical and genetic findings on the management of young patients with Brugadasyndrom?. ### Response: 2016.


Instruction: How is Brugada syn-drome managed?

Output: Asymptomatic Brugada syn-drome: clinical characterization and long-term prognosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is Brugada syn-drome managed?. ### Response: Asymptomatic Brugada syn-drome: clinical characterization and long-term prognosis.


Instruction: What is the name of the 2016 issue of Heart Rhythm?

Output: 13:1274–

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the 2016 issue of Heart Rhythm?. ### Response: 13:1274–.


Instruction: Who wrote the con-sensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes?

Output: Priori SG, Wilde AA, Horie M, et al. HRS/EHRA/APHRS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who wrote the con-sensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes?. ### Response: Priori SG, Wilde AA, Horie M, et al. HRS/EHRA/APHRS.


Instruction: What is the target or maximum tolerated dose of an ARB?

Output: Once the target or maximum tolerated dose  of an ARB  is reached, monitor treatment monthly for 3  months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the target or maximum tolerated dose of an ARB?. ### Response: Once the target or maximum tolerated dose  of an ARB  is reached, monitor treatment monthly for 3  months.


Instruction: How long does it take to monitor treatment?

Output: 3  months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take to monitor treatment?. ### Response: 3  months.


Instruction: How long does it take to monitor a person's treatment?

Output: 3  months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does it take to monitor a person's treatment?. ### Response: 3  months.