Instruction: Manifest pathways occur in 0.1% to 0.3% of the population and may conduct in both the anterograde and ret-rograde directions?

Output: Manifest pathways occur in 0.1% to 0.3% of the population and may conduct in both the anterograde and ret-rograde directions or, less commonly, only in the anterograde direction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Manifest pathways occur in 0.1% to 0.3% of the population and may conduct in both the anterograde and ret-rograde directions?. ### Response: Manifest pathways occur in 0.1% to 0.3% of the population and may conduct in both the anterograde and ret-rograde directions or, less commonly, only in the anterograde direction.


Instruction: Concealed pathways conduct only in what direction?

Output: retro-grade

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Concealed pathways conduct only in what direction?. ### Response: retro-grade.


Instruction: What does not cause pre-excitation on the standard 12-lead ECG?

Output: Concealed pathways

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not cause pre-excitation on the standard 12-lead ECG?. ### Response: Concealed pathways.


Instruction: What is the most common tachycardia associated with an accessory pathway?

Output: orthodromic A VRT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most common tachycardia associated with an accessory pathway?. ### Response: orthodromic A VRT.


Instruction: How does the circuit use the A V node and His Purkinje system in the antero-grade direction?

Output: retrogradely

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does the circuit use the A V node and His Purkinje system in the antero-grade direction?. ### Response: retrogradely.


Instruction: What percentage of A VRT episodes occur in patients with a manifest accessory pathway?

Output: 5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of A VRT episodes occur in patients with a manifest accessory pathway?. ### Response: 5%.


Instruction: What is the name of the pathway that is retrogradely conducted over?

Output: accessory pathway

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the pathway that is retrogradely conducted over?. ### Response: accessory pathway.


Instruction: How much of the A VRT episodes in patients with a manifest accessory pathway are pre-excited?

Output: 5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much of the A VRT episodes in patients with a manifest accessory pathway are pre-excited?. ### Response: 5%.


Instruction: What is involved in conduction from the atrium to the ventricle via the acces-sory pathway?

Output: Pre-excited A VRT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is involved in conduction from the atrium to the ventricle via the acces-sory pathway?. ### Response: Pre-excited A VRT.


Instruction: What is a pre-excited QRS complex called?

Output: antidromic A VRT tachycardia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a pre-excited QRS complex called?. ### Response: antidromic A VRT tachycardia.


Instruction: What does antidromic A VRT tachycardia occur when the return reentrant conduction occurs retrogradely via the A V node?

Output: pre-excited QRS complex

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does antidromic A VRT tachycardia occur when the return reentrant conduction occurs retrogradely via the A V node?. ### Response: pre-excited QRS complex.


Instruction: How does the return conduction occur in rare cases?

Output: via a second accessory A V pathway

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does the return conduction occur in rare cases?. ### Response: via a second accessory A V pathway.


Instruction: What can occur in patients with accessory pathways?

Output: AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can occur in patients with accessory pathways?. ### Response: AF.


Instruction: What increases the risk of inducing ventricular fibrillation and SCD?

Output: anterograde pathways

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What increases the risk of inducing ventricular fibrillation and SCD?. ### Response: anterograde pathways.


Instruction: A VNRT, AT, and atrial flutter can conduct what?

Output: rapidly over a manifest accessory pathway

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A VNRT, AT, and atrial flutter can conduct what?. ### Response: rapidly over a manifest accessory pathway.


Instruction: A VNRT, AT, and atrial flutter can conduct rapidly over what?

Output: a manifest accessory pathway

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: A VNRT, AT, and atrial flutter can conduct rapidly over what?. ### Response: a manifest accessory pathway.


Instruction: What is the pathway con-sidered a "bystander" because it is not part of the tachy-cardia circuit?

Output: manifest accessory pathway

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the pathway con-sidered a "bystander" because it is not part of the tachy-cardia circuit?. ### Response: manifest accessory pathway.


Instruction: What has been shown to result in rapid reperfusion times and excellent clini-cal outcomes?

Output: preferential transport to a PCI-capable hospital

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been shown to result in rapid reperfusion times and excellent clini-cal outcomes?. ### Response: preferential transport to a PCI-capable hospital.


Instruction: What does the AHA and National Institutes of Health "Act in Time to Heart Attack Signs" campaign emphasize?

Output: patients can increase their chance of surviving STEMI by learning the warning symptoms, filling out a survival plan, and discuss-ing risk reduction with their physician

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the AHA and National Institutes of Health "Act in Time to Heart Attack Signs" campaign emphasize?. ### Response: patients can increase their chance of surviving STEMI by learning the warning symptoms, filling out a survival plan, and discuss-ing risk reduction with their physician.


Instruction: What should health-care providers target their educational interventions to?

Output: patients at increased risk for ACS

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should health-care providers target their educational interventions to?. ### Response: patients at increased risk for ACS.


Instruction: What should patients at increased risk of STEMI do?

Output: learning the warning symptoms, filling out a survival plan, and discuss-ing risk reduction with their physician

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients at increased risk of STEMI do?. ### Response: learning the warning symptoms, filling out a survival plan, and discuss-ing risk reduction with their physician.


Instruction: Who should target their educational interventions to patients at increased risk for ACS?

Output: Health-care providers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who should target their educational interventions to patients at increased risk for ACS?. ### Response: Health-care providers.


Instruction: What does ED stand for?

Output: Emergency departments

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does ED stand for?. ### Response: Emergency departments.


Instruction: What is the default safety net for millions of Americans?

Output: EDs)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the default safety net for millions of Americans?. ### Response: EDs).


Instruction: EDs are equipped to evaluate and manage what type of illness?

Output: acute life-threatening

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: EDs are equipped to evaluate and manage what type of illness?. ### Response: acute life-threatening.


Instruction: What type of services are ED's increasingly called on to provide?

Output: primary care and primary prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of services are ED's increasingly called on to provide?. ### Response: primary care and primary prevention.


Instruction: What is an example of a health promotion-tion and disease prevention service offered in the ED?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a health promotion-tion and disease prevention service offered in the ED?. ### Response: stroke.


Instruction: What type of care is often associated with primary care?

Output: EDs are equipped to evaluate and manage acute life-threatening illness yet are increasingly called on to provide services

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of care is often associated with primary care?. ### Response: EDs are equipped to evaluate and manage acute life-threatening illness yet are increasingly called on to provide services.


Instruction: What is the primary reason for a ED visit?

Output: to reinforce healthy living

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary reason for a ED visit?. ### Response: to reinforce healthy living.


Instruction: What can the ED encounter serve to reinforce?

Output: healthy living

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can the ED encounter serve to reinforce?. ### Response: healthy living.


Instruction: What is another term for referring patients to primary care providers for continued management of existing disease?

Output: tertiary prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another term for referring patients to primary care providers for continued management of existing disease?. ### Response: tertiary prevention.


Instruction: How many Americans are using the ED for primary care?

Output: num-bers

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many Americans are using the ED for primary care?. ### Response: num-bers.


Instruction: What may the ED present a unique opportunity to reduce?

Output: cerebrovascular disease and CVD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may the ED present a unique opportunity to reduce?. ### Response: cerebrovascular disease and CVD.


Instruction: What must be tempered by the higher cost of providing care in this setting?

Output: Enthusiasm to use the ED as a site for initiating primary and secondary preventative services

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must be tempered by the higher cost of providing care in this setting?. ### Response: Enthusiasm to use the ED as a site for initiating primary and secondary preventative services.


Instruction: What is the list of potentially modifiable stroke risk factors as reviewed in this guideline?

Output: extensive

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the list of potentially modifiable stroke risk factors as reviewed in this guideline?. ### Response: extensive.


Instruction: What is set and per-formance pressures on the ED personnel to decrease?

Output: length of stay, rates of patients who leave without treatment, overall wait times, and resource use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is set and per-formance pressures on the ED personnel to decrease?. ### Response: length of stay, rates of patients who leave without treatment, overall wait times, and resource use.


Instruction: What must ED personnel know in order to effectively initiate primary preventive strategies?

Output: the risk factors for various diseases

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must ED personnel know in order to effectively initiate primary preventive strategies?. ### Response: the risk factors for various diseases.


Instruction: What are the risk factors for various diseases in stroke?

Output: ED personnel must know the risk factors for various diseases, in this case stroke; must understand the appropriate diagnostic evaluations and definitions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the risk factors for various diseases in stroke?. ### Response: ED personnel must know the risk factors for various diseases, in this case stroke; must understand the appropriate diagnostic evaluations and definitions.


Instruction: What must be aware of recommendations for appropriate interventions?

Output: ED personnel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must be aware of recommendations for appropriate interventions?. ### Response: ED personnel.


Instruction: Who must be able to arrange primary care follow-up to assess the effect of initiated preventive interventions.

Output: ED personnel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who must be able to arrange primary care follow-up to assess the effect of initiated preventive interventions.. ### Response: ED personnel.


Instruction: What will require engaging and enabling already largely receptive ED professionals?

Output: Adding delivery of primary care and primary prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What will require engaging and enabling already largely receptive ED professionals?. ### Response: Adding delivery of primary care and primary prevention.


Instruction: 900ED visits serve as opportunities to screen and potentially treat patients with what?

Output: asymptomatic hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: 900ED visits serve as opportunities to screen and potentially treat patients with what?. ### Response: asymptomatic hypertension.


Instruction: What is the prevalence of asymptomatic hypertension in patients presenting to the ED?

Output: 1 in 20.901

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the prevalence of asymptomatic hypertension in patients presenting to the ED?. ### Response: 1 in 20.901.


Instruction: What may be as high as 1 in 20.901?

Output: The prevalence of asymptomatic hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be as high as 1 in 20.901?. ### Response: The prevalence of asymptomatic hypertension.


Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020 Page 48 of 127?

Output: Table 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction June 2020 Page 48 of 127?. ### Response: Table 2.


Instruction: What does Mor e Intense Lipid Lowering do to CVD Outcomes and Diabetes?

Output: Effect

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Mor e Intense Lipid Lowering do to CVD Outcomes and Diabetes?. ### Response: Effect.


Instruction: What is the primary endpoint of a Meta -analysis?

Output: Relative Risk Absolute Risk Meta -regression

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary endpoint of a Meta -analysis?. ### Response: Relative Risk Absolute Risk Meta -regression.


Instruction: What is one mmol/L?

Output: Relative Risk Absolute Risk Meta -regression

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one mmol/L?. ### Response: Relative Risk Absolute Risk Meta -regression.


Instruction: How many RCTs of subjects at risk for stroke were conducted in 2019?

Output: 0.84

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many RCTs of subjects at risk for stroke were conducted in 2019?. ### Response: 0.84.


Instruction: What is the difference between statins and non-statins for stroke LDL lowering?

Output: 2.6% versus 3.1%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between statins and non-statins for stroke LDL lowering?. ### Response: 2.6% versus 3.1%.


Instruction: Stroke 0.84 (95% CI: 0.78, 0.90) 2.6% versus 3.1%  stroke risk by what percentage?

Output: 23.5%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Stroke 0.84 (95% CI: 0.78, 0.90) 2.6% versus 3.1%  stroke risk by what percentage?. ### Response: 23.5%.


Instruction: LDL-C level: 1.3 mmoI/L versus higher levels?

Output: ≤1.3 mmoI/L (50 mg/dL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: LDL-C level: 1.3 mmoI/L versus higher levels?. ### Response: ≤1.3 mmoI/L (50 mg/dL.


Instruction: What is the LDL-C level versus higher levels (control)?

Output: ≤1.3 mmoI/L (50 mg/dL)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the LDL-C level versus higher levels (control)?. ### Response: ≤1.3 mmoI/L (50 mg/dL).


Instruction: What percentage of the population has a 1.3 mmoI/L (50 mg/dL) compared to higher levels?

Output: LDL-C level

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the population has a 1.3 mmoI/L (50 mg/dL) compared to higher levels?. ### Response: LDL-C level.


Instruction: What percentage of LDL-C level is higher than the control?

Output: 0.79

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of LDL-C level is higher than the control?. ### Response: 0.79.


Instruction: What is the CI for LDL lowering?

Output: 0.92 – 1.10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the CI for LDL lowering?. ### Response: 0.92 – 1.10.


Instruction: What is the difference between statin and non-statin therapies for MI, CHD, or CVD death?

Output: 0.77

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between statin and non-statin therapies for MI, CHD, or CVD death?. ### Response: 0.77.


Instruction: Statins RR: 0.77 (95% CI: 0.71 – 0.84, p.001) What is non- statin RR?

Output: 0.75

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Statins RR: 0.77 (95% CI: 0.71 – 0.84, p.001) What is non- statin RR?. ### Response: 0.75.


Instruction: Navarese et al. (2018) [111] LDL lowering trials with what drugs?

Output: statin and non-statin therapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Navarese et al. (2018) [111] LDL lowering trials with what drugs?. ### Response: statin and non-statin therapies.


Instruction: Navarese et al. (2018) [111] LDL lowering trials with initial low LDL More intensive compared with less intensive lowering?

Output: placebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Navarese et al. (2018) [111] LDL lowering trials with initial low LDL More intensive compared with less intensive lowering?. ### Response: placebo.


Instruction: Total and CVD death 0.92 (95% CI: 0.88 – 0.96)

Output: baseline LDL level

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Total and CVD death 0.92 (95% CI: 0.88 – 0.96). ### Response: baseline LDL level.


Instruction: What is the RR of non-statins?

Output: 0.79

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the RR of non-statins?. ### Response: 0.79.


Instruction: What are statins RR: 0.78?

Output: 0.65 – 0.94

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are statins RR: 0.78?. ### Response: 0.65 – 0.94.


Instruction: What is the RR of statins?

Output: 0.77

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the RR of statins?. ### Response: 0.77.


Instruction: What is it about non-statins that makes them RR?

Output: 0.75

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is it about non-statins that makes them RR?. ### Response: 0.75.


Instruction: How does Cai describe the results of his LDL lowering trials?

Output: <1.8 mmol/L (<70 mg/dL)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does Cai describe the results of his LDL lowering trials?. ### Response: <1.8 mmol/L (<70 mg/dL).


Instruction: What type of diabetes is 1.33?

Output: New- onset

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diabetes is 1.33?. ### Response: New- onset.


Instruction: What is the LDL-C level in New-onset diabetes?

Output: 1.33

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the LDL-C level in New-onset diabetes?. ### Response: 1.33.


Instruction: How many mmol/L are there in new-onset diabetics?

Output: 1.33

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many mmol/L are there in new-onset diabetics?. ### Response: 1.33.


Instruction: What percentage of the population had LDL levels between 0.92 and 1.10?

Output: 95%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of the population had LDL levels between 0.92 and 1.10?. ### Response: 95%.


Instruction: What was the ratio of mmol/L to mg/dL?

Output: millimoles per liter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the ratio of mmol/L to mg/dL?. ### Response: millimoles per liter.


Instruction: How was the LDL level converted?

Output: by multiplying by 38.6

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the LDL level converted?. ### Response: by multiplying by 38.6.


Instruction: Which abbreviation does CABG stand for?

Output: coronary artery bypass grafting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Which abbreviation does CABG stand for?. ### Response: coronary artery bypass grafting.


Instruction: What is LDL -C?

Output: low -density lipoprotein cholesterol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is LDL -C?. ### Response: low -density lipoprotein cholesterol.


Instruction: What is MI?

Output: myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is MI?. ### Response: myocardial infarction.


Instruction: How many milligrams per deciliter?

Output: mg/dL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many milligrams per deciliter?. ### Response: mg/dL.


Instruction: Powers et al 2019 Guidelines for Management of AIS e3713.6. Other IV Fibrinolytics and Sonothrombolysis COR LOE New, Revised, or Unchanged What is tenecteplase?

Output: single IV bolus of 0.25-mg/kg, maximum 25 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Powers et al 2019 Guidelines for Management of AIS e3713.6. Other IV Fibrinolytics and Sonothrombolysis COR LOE New, Revised, or Unchanged What is tenecteplase?. ### Response: single IV bolus of 0.25-mg/kg, maximum 25 mg.


Instruction: What is the maximum dose of IV tenecteplase?

Output: 0.4-mg/kg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the maximum dose of IV tenecteplase?. ### Response: 0.4-mg/kg.


Instruction: What was the usual dose of 0.9 mg/kg over 60 minutes in the EXTEND-IA?

Output: IV alteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the usual dose of 0.9 mg/kg over 60 minutes in the EXTEND-IA?. ### Response: IV alteplase.


Instruction: How many patients were randomized in the EXTEND-IA TNK trial?

Output: 202

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were randomized in the EXTEND-IA TNK trial?. ### Response: 202.


Instruction: What is the maximum dose of Tenecteplase before endovascular therapy for Ischemic Stroke?

Output: 90 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the maximum dose of Tenecteplase before endovascular therapy for Ischemic Stroke?. ### Response: 90 mg.


Instruction: What is proximal MCA?

Output: M1 or M2 segments

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is proximal MCA?. ### Response: M1 or M2 segments.


Instruction: How long after symptom onset do basilar arteries present to receive 1 fibrinolytic agent?

Output: 4.5 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after symptom onset do basilar arteries present to receive 1 fibrinolytic agent?. ### Response: 4.5 hours.


Instruction: What is the primary end point of reperfusion?

Output: >50% of the involved ischemic territory

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the primary end point of reperfusion?. ### Response: >50% of the involved ischemic territory.


Instruction: What was the primary end point achieved by 22% of patients treated with NIHSS?

Output: tenecteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary end point achieved by 22% of patients treated with NIHSS?. ### Response: tenecteplase.


Instruction: What did the trial test for noninferiority and, if nonproven, for superiority?

Output: P=0.002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the trial test for noninferiority and, if nonproven, for superiority?. ### Response: P=0.002.


Instruction: How long did the mRS score last?

Output: 90 days

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did the mRS score last?. ### Response: 90 days.


Instruction: What percentage of patients treated with tenecteplase achieved the end point?

Output: 22%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients treated with tenecteplase achieved the end point?. ### Response: 22%.


Instruction: How many patients were treated with alteplasse?

Output: 10%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were treated with alteplasse?. ### Response: 10%.


Instruction: What was the P value for noninferiority and superiority?

Output: 0.002

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the P value for noninferiority and superiority?. ### Response: 0.002.


Instruction: In an analysis of secondary end points, what resulted in better functional outcomes at 90 days?

Output: tenecteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In an analysis of secondary end points, what resulted in better functional outcomes at 90 days?. ### Response: tenecteplase.


Instruction: What was the sICH rate in both studies?

Output: 1%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the sICH rate in both studies?. ### Response: 1%.


Instruction: How long did it take to obtain an mRS score of 0 to 1?

Output: P=0.23

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take to obtain an mRS score of 0 to 1?. ### Response: P=0.23.


Instruction: What was the sICH rate in both groups?

Output: 1%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the sICH rate in both groups?. ### Response: 1%.


Instruction: What is a possible alternative to alteplase?

Output: Tenecteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a possible alternative to alteplase?. ### Response: Tenecteplase.


Instruction: What can be considered as an alternative to alteplase in patients with minor neurological impairment?

Output: Tenecteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be considered as an alternative to alteplase in patients with minor neurological impairment?. ### Response: Tenecteplase.


Instruction: How long after stroke has IV tenectase been compared with IV alteplases?

Output: up to 6 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after stroke has IV tenectase been compared with IV alteplases?. ### Response: up to 6 hours.


Instruction: In 3 phase II and 1 phase III superiority trials, what appears to be similar?

Output: tenecteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In 3 phase II and 1 phase III superiority trials, what appears to be similar?. ### Response: tenecteplase.


Instruction: What appears to be similar to tenecteplase but is unclear whether it is as effective as or more effective than alteplas?

Output: safe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What appears to be similar to tenecteplase but is unclear whether it is as effective as or more effective than alteplas?. ### Response: safe.


Instruction: How many subjects were in the largest trial?

Output: 202

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many subjects were in the largest trial?. ### Response: 202.


Instruction: What dose did the biggest trial fail to demonstrate superiority?

Output: 0.4 mg/kg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What dose did the biggest trial fail to demonstrate superiority?. ### Response: 0.4 mg/kg.


Instruction: What is given as a single IV bolus as opposed to the 1-hour infusion?

Output: Tenecteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is given as a single IV bolus as opposed to the 1-hour infusion?. ### Response: Tenecteplase.


Instruction: What is the median NIHSS score?

Output: 17

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the median NIHSS score?. ### Response: 17.


Instruction: What is the difference between a single IV bolus and a 1-hour infusion of alteplase?

Output: Tenecteplase

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the difference between a single IV bolus and a 1-hour infusion of alteplase?. ### Response: Tenecteplase.


Instruction: What is Gemcitabine-induced acute coro-nary syndrome?

Output: a case report

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Gemcitabine-induced acute coro-nary syndrome?. ### Response: a case report.


Instruction: What are heart and vessels also being targeted for?

Output: Targeted therapies in breast cancer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are heart and vessels also being targeted for?. ### Response: Targeted therapies in breast cancer.


Instruction: What is targeted?

Output: breast cancer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is targeted?. ### Response: breast cancer.


Instruction: What is comprehensive insight into immune regulatory mechanisms and vascular wall determinants of atherogenesis?

Output: emerging perspectives of immunomodulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is comprehensive insight into immune regulatory mechanisms and vascular wall determinants of atherogenesis?. ### Response: emerging perspectives of immunomodulation.


Instruction: What year was With the Guidelines released?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was With the Guidelines released?. ### Response: 2009.


Instruction: What is the name of the study that investigated primary versus tenecteplase-facilitated percutaneous coronary intervention in patients with ST-segment elevation acute myocardial infarction?

Output: ASSENT-4 PCI Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study that investigated primary versus tenecteplase-facilitated percutaneous coronary intervention in patients with ST-segment elevation acute myocardial infarction?. ### Response: ASSENT-4 PCI Investigators.


Instruction: What is the name of the Task Force on Performance Measures?

Output: American College of Cardiology/American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Task Force on Performance Measures?. ### Response: American College of Cardiology/American Heart Association.


Instruction: When was the J Am Coll Cardiol.52:2113–7. 820?

Output: 2008

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Coll Cardiol.52:2113–7. 820?. ### Response: 2008.


Instruction: What is a regional system to provide timely care?

Output: percutaneous coronary intervention for ST-elevation myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a regional system to provide timely care?. ### Response: percutaneous coronary intervention for ST-elevation myocardial infarction.


Instruction: What is a regional system to provide timely access to percutaneous coronary intervention for ST-elevation myocardial infarction?

Output: Henry TD, Sharkey SW, Burke MN, et al

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a regional system to provide timely access to percutaneous coronary intervention for ST-elevation myocardial infarction?. ### Response: Henry TD, Sharkey SW, Burke MN, et al.


Instruction: Circulation. 2008;118:2662–6. 821. Curry HM, Anderson JL, Bachelder BL, et al. ACC/AHA 2008 performance measures for adults with what?

Output: ST-elevation and non-ST-elevation myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Circulation. 2008;118:2662–6. 821. Curry HM, Anderson JL, Bachelder BL, et al. ACC/AHA 2008 performance measures for adults with what?. ### Response: ST-elevation and non-ST-elevation myocardial infarction.


Instruction: What is a citywide protocol for primary PCI in?

Output: ST-segment elevation myocardial infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a citywide protocol for primary PCI in?. ### Response: ST-segment elevation myocardial infarction.


Instruction: What is a citywide protocol for primary PCI in ST-segment elevation myocardial infarction?

Output: 822

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a citywide protocol for primary PCI in ST-segment elevation myocardial infarction?. ### Response: 822.


Instruction: What is the name of the national cardiovascular data registry?

Output: Action Registry–GWTG

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the national cardiovascular data registry?. ### Response: Action Registry–GWTG.


Instruction: When was the Action Registry–GWTG released?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Action Registry–GWTG released?. ### Response: 2009.


Instruction: Where was the Measure Comparison (Inpatient Hospital Quality Measures) available?

Output: QualityNet.com

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where was the Measure Comparison (Inpatient Hospital Quality Measures) available?. ### Response: QualityNet.com.


Instruction: What year was the Acute Myocardial Infarction Core Measure Set released?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was the Acute Myocardial Infarction Core Measure Set released?. ### Response: 2009.


Instruction: When was the Joint Commission's Acute Measuring Core Set available?

Output: August

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Joint Commission's Acute Measuring Core Set available?. ### Response: August.


Instruction: What year were the results of the systematic review of ran-domized trials of disease management programs in heart failure published?

Output: 2001

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year were the results of the systematic review of ran-domized trials of disease management programs in heart failure published?. ### Response: 2001.


Instruction: How many ran-domized trials of disease management programs in heart failure were conducted in 2001?

Output: 827

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many ran-domized trials of disease management programs in heart failure were conducted in 2001?. ### Response: 827.


Instruction: What is the name of the journal that published the study on the evidence on the chronic care model in the new millennium?

Output: Health Aff (Millwood).

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the journal that published the study on the evidence on the chronic care model in the new millennium?. ### Response: Health Aff (Millwood)..


Instruction: Who is the Director of Strategic Planning for the Cardiovascular Division at Brigham and Women's Hospital?

Output: Patrick T. O’Gara

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Director of Strategic Planning for the Cardiovascular Division at Brigham and Women's Hospital?. ### Response: Patrick T. O’Gara.


Instruction: What is the ACC/AHA Task Force on Clinical Practice Guidelines?

Output: Content Reviewer

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the ACC/AHA Task Force on Clinical Practice Guidelines?. ### Response: Content Reviewer.


Instruction: Where is the Watkins Family Distinguished Chair in Cardiology located?

Output: Harvard Medical School

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the Watkins Family Distinguished Chair in Cardiology located?. ### Response: Harvard Medical School.


Instruction: What is the name of the professor of medicine at Harvard Medical School?

Output: Watkins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the professor of medicine at Harvard Medical School?. ### Response: Watkins.


Instruction: Who is the author of the Task Force on Clinical Practice Guidelines?

Output: Joshua A. Beckman

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the author of the Task Force on Clinical Practice Guidelines?. ### Response: Joshua A. Beckman.


Instruction: Who is the Director of Vascular Medicine at Vanderbilt University?

Output: Centro Medico Diagnostico

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Director of Vascular Medicine at Vanderbilt University?. ### Response: Centro Medico Diagnostico.


Instruction: Where is Aralez Pharmaceuticals located?

Output: Vanderbilt University

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is Aralez Pharmaceuticals located?. ### Response: Vanderbilt University.


Instruction: Who is ER Squibb & Sons?

Output: Boehringer Ingelheim Pharmaceuticals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is ER Squibb & Sons?. ### Response: Boehringer Ingelheim Pharmaceuticals.


Instruction: What is the name of the data safety monitoring board at Bayer?

Output: Novartis Corporation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the data safety monitoring board at Bayer?. ### Response: Novartis Corporation.


Instruction: Who is the Data Safety Monitoring Board of Novartis Corporation?

Output: PCORI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Data Safety Monitoring Board of Novartis Corporation?. ### Response: PCORI.


Instruction: Who is responsible for Vascular Interventional Advances Officer, Director, Trustee or other Fiduciary Role?

Output: JanaCare

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is responsible for Vascular Interventional Advances Officer, Director, Trustee or other Fiduciary Role?. ### Response: JanaCare.


Instruction: What is Michael E. DeBakey VA Medical Center & Baylor College of Medicine Professor?

Output: Chief, Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Michael E. DeBakey VA Medical Center & Baylor College of Medicine Professor?. ### Response: Chief, Cardiology.


Instruction: Who is the current Chair and Member of the AHA Committee on Heart Failure and Transplantation?

Output: Anita Deswal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the current Chair and Member of the AHA Committee on Heart Failure and Transplantation?. ### Response: Anita Deswal.


Instruction: Who is a Content Reviewer for the ACC/AHA Task Force on Clinical Practice Guidelines?

Output: Joshua A. Beckman

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is a Content Reviewer for the ACC/AHA Task Force on Clinical Practice Guidelines?. ### Response: Joshua A. Beckman.


Instruction: Who is the Content Reviewer for the ACC/AHA Task Force on Clinical Practice Guidelines?

Output: Joshua A. Beckman

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is the Content Reviewer for the ACC/AHA Task Force on Clinical Practice Guidelines?. ### Response: Joshua A. Beckman.


Instruction: What is the name of the program director for the Clinical Cardiac Electrophysiology Fellowship Program?

Output: José A. Joglar

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the program director for the Clinical Cardiac Electrophysiology Fellowship Program?. ### Response: José A. Joglar.


Instruction: What is PCORI?

Output: Data Safety Monitoring Board

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is PCORI?. ### Response: Data Safety Monitoring Board.


Instruction: What does PCORI stand for?

Output: Data Safety Monitoring Board

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does PCORI stand for?. ### Response: Data Safety Monitoring Board.


Instruction: Where is the PCORI located?

Output: Ottawa, Ontario, Canada

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is the PCORI located?. ### Response: Ottawa, Ontario, Canada.


Instruction: Who is an Employment Consultant Speakers BureauOwnership/Partnership / Principal Personal ResearchInstitutional, Organizational, or Other Financial Benefit Expert Witness Salary(Continued )Downloaded from http://ahajournals.org by on May 1, 2023?

Output: ContinuedReviewer Representation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is an Employment Consultant Speakers BureauOwnership/Partnership / Principal Personal ResearchInstitutional, Organizational, or Other Financial Benefit Expert Witness Salary(Continued )Downloaded from http://ahajournals.org by on May 1, 2023?. ### Response: ContinuedReviewer Representation.


Instruction: What is an asterisk in this guideline?

Output: recommendations that are newly added or have beenchanged

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an asterisk in this guideline?. ### Response: recommendations that are newly added or have beenchanged.


Instruction: What indicates new recommendations that have been added or have been changed since the publication of Antithrombotic Therapyfor VTE Disease: Antithrombin Therapy and PreventionofThrombosis?

Output: shaded text

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What indicates new recommendations that have been added or have been changed since the publication of Antithrombotic Therapyfor VTE Disease: Antithrombin Therapy and PreventionofThrombosis?. ### Response: shaded text.


Instruction: What are the recommendations that remain unchanged since thatdition are not shaded?

Output: dabigatran,rivaroxaban, apixaban, edoxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the recommendations that remain unchanged since thatdition are not shaded?. ### Response: dabigatran,rivaroxaban, apixaban, edoxaban.


Instruction: The order of our presentation of thenon-vitamin K oral anticoagulants is based on thechronology of publication of what?

Output: phase 3 trials in VTEtreatment

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The order of our presentation of thenon-vitamin K oral anticoagulants is based on thechronology of publication of what?. ### Response: phase 3 trials in VTEtreatment.


Instruction: What should not be interpreted as the guidelinepanel’s order of preference for the use of these agents?

Output: edoxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not be interpreted as the guidelinepanel’s order of preference for the use of these agents?. ### Response: edoxaban.


Instruction: What should patients with proximal DVT or pulmonaryembolism (PE) receive?

Output: extended therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients with proximal DVT or pulmonaryembolism (PE) receive?. ### Response: extended therapy.


Instruction: How long does anticoagulant therapy last?

Output: 3 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long does anticoagulant therapy last?. ### Response: 3 months.


Instruction: What is the grade 1B of anticoagulants?

Output: shorter period

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the grade 1B of anticoagulants?. ### Response: shorter period.


Instruction: How long is anticoagulation therapy recommended for PE?

Output: 3 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is anticoagulation therapy recommended for PE?. ### Response: 3 months.


Instruction: What is VKA?

Output: vitamin K antagonist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is VKA?. ### Response: vitamin K antagonist.


Instruction: What is LMWH?

Output: low-molecular weight heparin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is LMWH?. ### Response: low-molecular weight heparin.


Instruction: When is initial parenteral anticoagulation given?

Output: before dabigatran and edoxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is initial parenteral anticoagulation given?. ### Response: before dabigatran and edoxaban.


Instruction: What is not given before dabigatran and edoxaban?

Output: Initial parenteral anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not given before dabigatran and edoxaban?. ### Response: Initial parenteral anticoagulation.


Instruction: What is overlapped with VKAtherapy?

Output: Initial parenteral anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is overlapped with VKAtherapy?. ### Response: Initial parenteral anticoagulation.


Instruction: In patients with DVT of the leg or PE and cancer, what is LMWHover VKA therapy?

Output: Grade 2B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with DVT of the leg or PE and cancer, what is LMWHover VKA therapy?. ### Response: Grade 2B.


Instruction: What is LMWHover VKA therapy?

Output: Grade 2B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is LMWHover VKA therapy?. ### Response: Grade 2B.


Instruction: What is dabigatran?

Output: vitamin K oral anticoagulants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is dabigatran?. ### Response: vitamin K oral anticoagulants.


Instruction: Is initial parenteral anticoagulation given?

Output: before dabigatran and edoxaban

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Is initial parenteral anticoagulation given?. ### Response: before dabigatran and edoxaban.


Instruction: What type of therapy is overlapped with VKAtherapy?

Output: Initial parenteral anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is overlapped with VKAtherapy?. ### Response: Initial parenteral anticoagulation.


Instruction: What are the factors that in fluence choice of therapy?

Output: changes in thepatient ’s circumstances or preferences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the factors that in fluence choice of therapy?. ### Response: changes in thepatient ’s circumstances or preferences.


Instruction: In patients with DVT of the leg or PE who receive extended therapy, we suggest there is no need to change the choice of what?

Output: anticoagulant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with DVT of the leg or PE who receive extended therapy, we suggest there is no need to change the choice of what?. ### Response: anticoagulant.


Instruction: What is the grade of anticoagulant?

Output: 1B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the grade of anticoagulant?. ### Response: 1B.


Instruction: What may be appropriate for the choice ofanticoagulant to change in response to changes in thepatient’s circumstances or preferences during long-term or extended phases of treatment?

Output: Long-Term (First 3 Months) and Extended

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be appropriate for the choice ofanticoagulant to change in response to changes in thepatient’s circumstances or preferences during long-term or extended phases of treatment?. ### Response: Long-Term (First 3 Months) and Extended.


Instruction: How long is anticoagulation recommended for in patients with a proximal leg?

Output: 3 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is anticoagulation recommended for in patients with a proximal leg?. ### Response: 3 months.


Instruction: What is the term for a shorter time-limited period of treatment?

Output: Grade 1B

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the term for a shorter time-limited period of treatment?. ### Response: Grade 1B.


Instruction: What is grade 1B?

Output: treatmentof a shorter period

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is grade 1B?. ### Response: treatmentof a shorter period.


Instruction: In patients with a proximal DVT of the leg or arm, what is a scheduledstop date?

Output: 3 months

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with a proximal DVT of the leg or arm, what is a scheduledstop date?. ### Response: 3 months.


Instruction: What is particularly pernicious in the heart?

Output: increased oxygen demand

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is particularly pernicious in the heart?. ### Response: increased oxygen demand.


Instruction: The heart is an aerobic organ that can develop only a small what?

Output: oxygen debt

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The heart is an aerobic organ that can develop only a small what?. ### Response: oxygen debt.


Instruction: What is almost maximal even at rest?

Output: oxygen extraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is almost maximal even at rest?. ### Response: oxygen extraction.


Instruction: What can increase little with increased demand?

Output: oxygen extraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can increase little with increased demand?. ### Response: oxygen extraction.


Instruction: What does lower BP improve in hypertensive patients?

Output: cardiovascular outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does lower BP improve in hypertensive patients?. ### Response: cardiovascular outcomes.


Instruction: How long is coronary perfusion maintained above the lower autoregulatory limit for coronary blood flow?

Output: as long

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is coronary perfusion maintained above the lower autoregulatory limit for coronary blood flow?. ### Response: as long.


Instruction: What could reduce coronary blood flow?

Output: any further reduction of DBP to levels below the lower autoregu-latory limit

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could reduce coronary blood flow?. ### Response: any further reduction of DBP to levels below the lower autoregu-latory limit.


Instruction: What could the reduction of DBP to levels below the lower autoregu-latory limit result in?

Output: reduce coronary blood flow

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could the reduction of DBP to levels below the lower autoregu-latory limit result in?. ### Response: reduce coronary blood flow.


Instruction: When DBP is lowered beyond this limit, what could happen?

Output: an upturn in the incidence of coronary events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When DBP is lowered beyond this limit, what could happen?. ### Response: an upturn in the incidence of coronary events.


Instruction: When is consumption increased such as during exercise?

Output: myocar -dial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When is consumption increased such as during exercise?. ### Response: myocar -dial.


Instruction: What would the relationship between DBP and coronary events show if this were true?

Output: a J-shaped curve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would the relationship between DBP and coronary events show if this were true?. ### Response: a J-shaped curve.


Instruction: What is the lower limit of autoregulation in the human coronary circu-lation, in healthy individuals, or in patients with hypertension and CAD?

Output: DBP level

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the lower limit of autoregulation in the human coronary circu-lation, in healthy individuals, or in patients with hypertension and CAD?. ### Response: DBP level.


Instruction: What is reasonable to assume that a rapid reduction in DBP to very low levels may be more hazardous?

Output: patients with combined hypertension and CAD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is reasonable to assume that a rapid reduction in DBP to very low levels may be more hazardous?. ### Response: patients with combined hypertension and CAD.


Instruction: What is hazardous in patients with combined hypertension and CAD?

Output: a rapid reduction in DBP to very low levels

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is hazardous in patients with combined hypertension and CAD?. ### Response: a rapid reduction in DBP to very low levels.


Instruction: What must we rely on to try to resolve this issue?

Output: clinical studies with surrogate end points and the few relevant clinical trials with outcomes data

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What must we rely on to try to resolve this issue?. ### Response: clinical studies with surrogate end points and the few relevant clinical trials with outcomes data.


Instruction: How many patients with CAD completed the intravascular ultrasound substudy of the CAMELOT trial?

Output: 274

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with CAD completed the intravascular ultrasound substudy of the CAMELOT trial?. ### Response: 274.


Instruction: How many subjects with a normal BP were found to have a lower BP?

Output: 274

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many subjects with a normal BP were found to have a lower BP?. ### Response: 274.


Instruction: What did the CAMELOT trial132 show?

Output: those subjects with a normal BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the CAMELOT trial132 show?. ### Response: those subjects with a normal BP.


Instruction: What was the mean decrease in coronary atheroma volume?

Output: 4.6 mm3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean decrease in coronary atheroma volume?. ### Response: 4.6 mm3.


Instruction: How many subjects had a normal BP according to the seventh report?

Output: 274

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many subjects had a normal BP according to the seventh report?. ### Response: 274.


Instruction: Pre-hypertensive subjects had no signifi-cant change in what?

Output: coronary atheroma volume

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Pre-hypertensive subjects had no signifi-cant change in what?. ### Response: coronary atheroma volume.


Instruction: What did the authors conclude about the optimal BP goal in patients with CAD?

Output: substantially lower than the <140/90 mm Hg level

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the authors conclude about the optimal BP goal in patients with CAD?. ### Response: substantially lower than the <140/90 mm Hg level.


Instruction: What may be substantially lower than the 140/90 mm Hg level in patients with CAD?

Output: the optimal BP goal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be substantially lower than the 140/90 mm Hg level in patients with CAD?. ### Response: the optimal BP goal.


Instruction: Why can the results of CAMELOT be taken only as hypothesis generating?

Output: because the effect of achieved BP on ath-eroma volume was not a prespecified outcome

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why can the results of CAMELOT be taken only as hypothesis generating?. ### Response: because the effect of achieved BP on ath-eroma volume was not a prespecified outcome.


Instruction: What was not a prespecified outcome?

Output: the effect of achieved BP on ath-eroma volume

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not a prespecified outcome?. ### Response: the effect of achieved BP on ath-eroma volume.


Instruction: What is a potential confounding effect of the post-hoc analysis?

Output: residual confound-ing effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a potential confounding effect of the post-hoc analysis?. ### Response: residual confound-ing effects.


Instruction: Why are the individuals in the higher BP cohort more likely to have been assigned to the placebo arm of the study?

Output: older

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why are the individuals in the higher BP cohort more likely to have been assigned to the placebo arm of the study?. ### Response: older.


Instruction: What is the name of the arm of the study that was not treated with amlodipine or enalapril?

Output: placebo

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the arm of the study that was not treated with amlodipine or enalapril?. ### Response: placebo.


Instruction: What would be clinically important if coronary autoregulation were?

Output: show a J-shaped curve

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would be clinically important if coronary autoregulation were?. ### Response: show a J-shaped curve.


Instruction: What is the date of the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction?

Output: June 2020

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the date of the VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction?. ### Response: June 2020.


Instruction: What is ezetimibe used for in higher risk patients who are willing to intensify treatment?

Output: secondary prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ezetimibe used for in higher risk patients who are willing to intensify treatment?. ### Response: secondary prevention.


Instruction: What should be added to moderate or high dose statins for reducing non -fatal cardiovascular events?

Output: ezetimibe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be added to moderate or high dose statins for reducing non -fatal cardiovascular events?. ### Response: ezetimibe.


Instruction: What do we suggest for secondary prevention in higher risk patients who are willing to intensify treatment?

Output: offering a PCSK9 inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do we suggest for secondary prevention in higher risk patients who are willing to intensify treatment?. ### Response: offering a PCSK9 inhibitor.


Instruction: What is a PCSK9 inhibitor in addition to?

Output: a maximally tolerated statin dose

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a PCSK9 inhibitor in addition to?. ### Response: a maximally tolerated statin dose.


Instruction: What is a PCSK9 inhibitor in addition to statin?

Output: ezetimibe

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a PCSK9 inhibitor in addition to statin?. ### Response: ezetimibe.


Instruction: What is another name for ezetimibe?

Output: PCSK9 inhibitor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for ezetimibe?. ### Response: PCSK9 inhibitor.


Instruction: What do patients value and preferences?

Output: additional benefits

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do patients value and preferences?. ### Response: additional benefits.


Instruction: What is weak for Reviewed, New-replaced c. Other Medications, Supplements, and Nutraceuticals 15. For primary or secondary prevention, we recommend against using what?

Output: routine  monitoring of lipid levels in patients taking statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is weak for Reviewed, New-replaced c. Other Medications, Supplements, and Nutraceuticals 15. For primary or secondary prevention, we recommend against using what?. ### Response: routine  monitoring of lipid levels in patients taking statins.


Instruction: What do we suggest against adding to statins for primary or secondary prevention?

Output: fibrates

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do we suggest against adding to statins for primary or secondary prevention?. ### Response: fibrates.


Instruction: What is insufficient evidence to recommend for or against using bempedoic acid?

Output: statins

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is insufficient evidence to recommend for or against using bempedoic acid?. ### Response: statins.


Instruction: Statins for either primary or secondary prevention?

Output: secondary

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Statins for either primary or secondary prevention?. ### Response: secondary.


Instruction: For primary prevention, there is insufficient evidence to recommend for or against icosapent ethyl in patients on statin therapy with persistently elevated fasting what?

Output: triglycerides

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For primary prevention, there is insufficient evidence to recommend for or against icosapent ethyl in patients on statin therapy with persistently elevated fasting what?. ### Response: triglycerides.


Instruction: Fasting triglycerides is neither for nor against what?

Output: Reviewed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Fasting triglycerides is neither for nor against what?. ### Response: Reviewed.


Instruction: For secondary prevention, what do we suggest for patients on statin therapy?

Output: icosapent ethyl

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For secondary prevention, what do we suggest for patients on statin therapy?. ### Response: icosapent ethyl.


Instruction: What does icosapent ethyl reduce?

Output: cardiovascular morbidity and mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does icosapent ethyl reduce?. ### Response: cardiovascular morbidity and mortality.


Instruction: What do we suggest against the use of omega -3 fatty acids as a dietary supplement to reduce cardiovascular disease risk?

Output: primary or secondary prevention

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do we suggest against the use of omega -3 fatty acids as a dietary supplement to reduce cardiovascular disease risk?. ### Response: primary or secondary prevention.


Instruction: What is not enough evidence to recommend for or against the use of fiber, garlic, ginger, green tea, and red yeast rice supplements to reduce cardiovascular risks?

Output: There is insufficient evidence to recommend for or against the use of fiber, garlic, ginger, green tea, and red yeast rice supplements to reduce cardiovascular risks.  Neither for nor against  Reviewed, New -added  d. Monitoring and Adherence  22

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not enough evidence to recommend for or against the use of fiber, garlic, ginger, green tea, and red yeast rice supplements to reduce cardiovascular risks?. ### Response: There is insufficient evidence to recommend for or against the use of fiber, garlic, ginger, green tea, and red yeast rice supplements to reduce cardiovascular risks.  Neither for nor against  Reviewed, New -added  d. Monitoring and Adherence  22.


Instruction: What do we suggest against the routine monitoring of lipid levels in patients taking statins?

Output: a washout period

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do we suggest against the routine monitoring of lipid levels in patients taking statins?. ### Response: a washout period.


Instruction: What do patients who cannot tolerate a statin need to do?

Output: a washout period

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do patients who cannot tolerate a statin need to do?. ### Response: a washout period.


Instruction: What is a washout period followed by a re-challenge with the same or a different statin or lower dose?

Output: For patients who cannot tolerate a statin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a washout period followed by a re-challenge with the same or a different statin or lower dose?. ### Response: For patients who cannot tolerate a statin.


Instruction: If that fails, a trial of what?

Output: intermittent (nondaily) dosing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: If that fails, a trial of what?. ### Response: intermittent (nondaily) dosing.


Instruction: What is the VA/DoD Clinical Practice Guideline for the Diagnosis and Management of Hypertension in the Primary Care Setting?

Output: March 2020

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for the Diagnosis and Management of Hypertension in the Primary Care Setting?. ### Response: March 2020.


Instruction: What is another name for mobile applications?

Output: mobile health application

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for mobile applications?. ### Response: mobile health application.


Instruction: What is the other name for electronic communication?

Output: exp

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the other name for electronic communication?. ### Response: exp.


Instruction: What is a personal digital assistant?

Output: smart phone OR cell* phone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a personal digital assistant?. ### Response: smart phone OR cell* phone.


Instruction: What is an adj2 phone?

Output: cellular OR mobile

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an adj2 phone?. ### Response: cellular OR mobile.


Instruction: What is an example of a personal digital assistant?

Output: smart phone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an example of a personal digital assistant?. ### Response: smart phone.


Instruction: What is a mobile health application?

Output: email

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a mobile health application?. ### Response: email.


Instruction: What is another name for "technology supported management" or "technology based intervention" OR internet based or computer based?

Output: texts

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for "technology supported management" or "technology based intervention" OR internet based or computer based?. ### Response: texts.


Instruction: What is ti,ab. #13?

Output: telemedicine

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is ti,ab. #13?. ### Response: telemedicine.


Instruction: What are telemedicine OR teleconsult?

Output: telehealth

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are telemedicine OR teleconsult?. ### Response: telehealth.


Instruction: What is another name for wireless adj2 consult*?

Output: telephone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is another name for wireless adj2 consult*?. ### Response: telephone.


Instruction: What is the other name for telephone adj2 consultation*

Output: remote

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the other name for telephone adj2 consultation*. ### Response: remote.


Instruction: What technology is used to combine HTN AND Technology #4 AND 14?

Output: BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What technology is used to combine HTN AND Technology #4 AND 14?. ### Response: BP.


Instruction: With Technology #7 AND #14 #17 Combine final technology sets #15 OR #16 #18 Allied health/delivery of care (nurse* OR nutritionist OR dietitian OR dietician OR pharmacist* OR health care personnel)

Output: BP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: With Technology #7 AND #14 #17 Combine final technology sets #15 OR #16 #18 Allied health/delivery of care (nurse* OR nutritionist OR dietitian OR dietician OR pharmacist* OR health care personnel). ### Response: BP.


Instruction: What does adj1 run stand for?

Output: pharmacist

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does adj1 run stand for?. ### Response: pharmacist.


Instruction: What is the acronym for pharmacist adj1 led?

Output: ti,ab. OR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for pharmacist adj1 led?. ### Response: ti,ab. OR.


Instruction: How many exp health personnel are there?

Output: #19

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many exp health personnel are there?. ### Response: #19.


Instruction: #19 #21 Combine delivery of care with HTN OR BP (#4 OR #7) AND #20 #22 Combine final sets #17 OR #21 Apply limits and what?

Output: hedges

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: #19 #21 Combine delivery of care with HTN OR BP (#4 OR #7) AND #20 #22 Combine final sets #17 OR #21 Apply limits and what?. ### Response: hedges.


Instruction: What is the maximum SBP of a study with established HF?

Output: 158 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the maximum SBP of a study with established HF?. ### Response: 158 mm Hg.


Instruction: How many studies were included in the meta-analysis?

Output: 10

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many studies were included in the meta-analysis?. ### Response: 10.


Instruction: What was the maximum SBP of the HF analysis?

Output: 158 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the maximum SBP of the HF analysis?. ### Response: 158 mm Hg.


Instruction: What percentage decrease in mortality rates was associated with a 10–mm Hg higher SBP?

Output: 13.0%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage decrease in mortality rates was associated with a 10–mm Hg higher SBP?. ### Response: 13.0%.


Instruction: In a recent study by Ather et al92, what did Ather and al92 incorporate data from?

Output: 2 large cohorts of ambulatory patients with chronic HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In a recent study by Ather et al92, what did Ather and al92 incorporate data from?. ### Response: 2 large cohorts of ambulatory patients with chronic HF.


Instruction: How many large cohorts of ambulatory patients with chronic HF were included in the study?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many large cohorts of ambulatory patients with chronic HF were included in the study?. ### Response: 2.


Instruction: What was found to have a nonlinear U-shaped association with mortality in patients with mild to moderate LV systolic dysfunction?

Output: SBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was found to have a nonlinear U-shaped association with mortality in patients with mild to moderate LV systolic dysfunction?. ### Response: SBP.


Instruction: What was found to have a nonlinear U-shaped association with increased all-cause mortality at both the lower and upper ranges of SBP?

Output: SBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was found to have a nonlinear U-shaped association with increased all-cause mortality at both the lower and upper ranges of SBP?. ### Response: SBP.


Instruction: What was not defined to have an association with mortality in a retro-spective analyses?

Output: SBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not defined to have an association with mortality in a retro-spective analyses?. ### Response: SBP.


Instruction: What were not defined or validated targets in a prospective, controlled trial?

Output: SBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were not defined or validated targets in a prospective, controlled trial?. ### Response: SBP.


Instruction: What should not be accepted as a target for BP control in patients with HF?

Output: SBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not be accepted as a target for BP control in patients with HF?. ### Response: SBP.


Instruction: What was found to have a linear association with lower SBP?

Output: SBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was found to have a linear association with lower SBP?. ### Response: SBP.


Instruction: What was associated with worse mortality?

Output: lower SBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with worse mortality?. ### Response: lower SBP.


Instruction: Who noted a differential prognostic effect of SBP on mortality according to LV function?

Output: Nuñez et al93

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who noted a differential prognostic effect of SBP on mortality according to LV function?. ### Response: Nuñez et al93.


Instruction: What is the prognostic effect of SBP on mortality according to LV function in patients with acute decompensated HF?

Output: differen-tial

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the prognostic effect of SBP on mortality according to LV function in patients with acute decompensated HF?. ### Response: differen-tial.


Instruction: The results suggest that the association between SBP and mortality may vary with what?

Output: LV function severity

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The results suggest that the association between SBP and mortality may vary with what?. ### Response: LV function severity.


Instruction: In patients with HF with preserved or mildly depressed what does SBP appear to have?

Output: nonlinear U-shaped relationship

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with HF with preserved or mildly depressed what does SBP appear to have?. ### Response: nonlinear U-shaped relationship.


Instruction: What appears to have a nonlinear U-shaped relationship with depressed LV function?

Output: SBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What appears to have a nonlinear U-shaped relationship with depressed LV function?. ### Response: SBP.


Instruction: What is the effect of baseline systolic blood pressure in all-cause mortality?

Output: increased all-cause mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the effect of baseline systolic blood pressure in all-cause mortality?. ### Response: increased all-cause mortality.


Instruction: What was the SBp in all-cause mortality in the Valsartan Heart Failure Trial?

Output: baseline systolic blood pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the SBp in all-cause mortality in the Valsartan Heart Failure Trial?. ### Response: baseline systolic blood pressure.


Instruction: When was the download from http://ahajournals.org by?

Output: May 3, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the download from http://ahajournals.org by?. ### Response: May 3, 2023.


Instruction: What is defined as the extent to which one can be confident that the desirable effects of an intervention outweigh its undesirable effects?

Output: The strength of a recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is defined as the extent to which one can be confident that the desirable effects of an intervention outweigh its undesirable effects?. ### Response: The strength of a recommendation.


Instruction: Who developed the Task Force on Prosthetic Valves?

Output: American College of Cardiology Cardiovascular Imaging Committee

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who developed the Task Force on Prosthetic Valves?. ### Response: American College of Cardiology Cardiovascular Imaging Committee.


Instruction: What is a registered branch of the European Society of Cardiology?

Output: European Association of Echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a registered branch of the European Society of Cardiology?. ### Response: European Association of Echocardiography.


Instruction: What is the Japanese Society of Echocardiography?

Output: a registered branch of the European Society of Cardiology

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Japanese Society of Echocardiography?. ### Response: a registered branch of the European Society of Cardiology.


Instruction: What are the names of the Society of Cardiology and the Canadian Society?

Output: Japanese Society of Echocardiography and the Canadian Society of Echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the names of the Society of Cardiology and the Canadian Society?. ### Response: Japanese Society of Echocardiography and the Canadian Society of Echocardiography.


Instruction: When was the J Am Soc Echocardiogr. 22:975-1014?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the J Am Soc Echocardiogr. 22:975-1014?. ### Response: 2009.


Instruction: What is throm-bolysis?

Output: first choice therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is throm-bolysis?. ### Response: first choice therapy.


Instruction: What is the first choice therapy in prosthetic heart valve thrombosis?

Output: Throm-bolysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the first choice therapy in prosthetic heart valve thrombosis?. ### Response: Throm-bolysis.


Instruction: How many patients participated in the study?

Output: 68

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients participated in the study?. ### Response: 68.


Instruction: How many patients were enrolled in a study of prosthetic heart valve thrombosis?

Output: 68

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were enrolled in a study of prosthetic heart valve thrombosis?. ### Response: 68.


Instruction: What is the name of the study of 68 patients?

Output: J Thromb Thrombolysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the study of 68 patients?. ### Response: J Thromb Thrombolysis.


Instruction: Urgent surgery compared with fibrinolytic therapy for the treatment of what?

Output: left-sided prosthetic heart valve thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Urgent surgery compared with fibrinolytic therapy for the treatment of what?. ### Response: left-sided prosthetic heart valve thrombosis.


Instruction: What is a first line therapy for prosthetic heart valve thrombosis?

Output: Throm-bolysis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a first line therapy for prosthetic heart valve thrombosis?. ### Response: Throm-bolysis.


Instruction: What is the name of the systematic review and meta-analysis of observational studies?

Output: Urgent surgery

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the systematic review and meta-analysis of observational studies?. ### Response: Urgent surgery.


Instruction: When did Eur Heart J. 2013 issue 34:1557-66?

Output: 2013

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Eur Heart J. 2013 issue 34:1557-66?. ### Response: 2013.


Instruction: How many events did Nagy A, Dénes M, Lengyel M study?

Output: 62

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many events did Nagy A, Dénes M, Lengyel M study?. ### Response: 62.


Instruction: What was the outcome of thrombolytic therapy in prosthetic mitral valve thombosis?

Output: delayed presentation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the outcome of thrombolytic therapy in prosthetic mitral valve thombosis?. ### Response: delayed presentation.


Instruction: When did zkan M, akal B, Karakoyun S, et al. study 62 events?

Output: 2009

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did zkan M, akal B, Karakoyun S, et al. study 62 events?. ### Response: 2009.


Instruction: What is used for the treatment of prosthetic heart valve thrombosis in pregnancy?

Output: low-dose, slow infusion of tissue-type plasminogen activator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used for the treatment of prosthetic heart valve thrombosis in pregnancy?. ### Response: low-dose, slow infusion of tissue-type plasminogen activator.


Instruction: What is low-dose, slow infusion of tissue-type plasminogen activator used for?

Output: treatment of prosthetic heart valve thrombosis in pregnancy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is low-dose, slow infusion of tissue-type plasminogen activator used for?. ### Response: treatment of prosthetic heart valve thrombosis in pregnancy.