Instruction: What was the result of a large prospectivestudy?

Output: Risk factors related to infections of implantedpacemakers and cardioverter-defibrillators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the result of a large prospectivestudy?. ### Response: Risk factors related to infections of implantedpacemakers and cardioverter-defibrillators.


Instruction: What is the name of the meta-analysis of antibiotic prophylaxis for permanent pacemakerimplantation?

Output: PEOPLE Study Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the meta-analysis of antibiotic prophylaxis for permanent pacemakerimplantation?. ### Response: PEOPLE Study Group.


Instruction: What year did Circulation issue 97:1796–1801.23?

Output: 1998

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Circulation issue 97:1796–1801.23?. ### Response: 1998.


Instruction: How long did it take to observe infection aftercardioverter-defibrillator implant?

Output: over10 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take to observe infection aftercardioverter-defibrillator implant?. ### Response: over10 years.


Instruction: How many patients were observed over 10 years?

Output: 335

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were observed over 10 years?. ### Response: 335.


Instruction: What was the duration of observation in 335 patients?

Output: over10 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the duration of observation in 335 patients?. ### Response: over10 years.


Instruction: Where were infections associated with implantable cardio-verter defibrillators placed?

Output: transvenously and via thoracotomies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where were infections associated with implantable cardio-verter defibrillators placed?. ### Response: transvenously and via thoracotomies.


Instruction: How long did observation last?

Output: over10 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did observation last?. ### Response: over10 years.


Instruction: What is therelation between patients’ outcomes and the volume of cardioverter-defibrillator implantation procedures performed by physicians treatingMedicare beneficiaries?

Output: Risk factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is therelation between patients’ outcomes and the volume of cardioverter-defibrillator implantation procedures performed by physicians treatingMedicare beneficiaries?. ### Response: Risk factors.


Instruction: What is Staphylococcusaureus bacteremia in patients with permanent pacemakers orimplantable cardioverter-defibrillators?

Output: Staphylococcusaureus bacteremia in patients with permanent pacemakers orimplantable cardioverter-defibrillators. Circulation . 2001;104:1029–1033.27

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is Staphylococcusaureus bacteremia in patients with permanent pacemakers orimplantable cardioverter-defibrillators?. ### Response: Staphylococcusaureus bacteremia in patients with permanent pacemakers orimplantable cardioverter-defibrillators. Circulation . 2001;104:1029–1033.27.


Instruction: When did Circulation. 2001;104:1029–1033.27.

Output: 2001

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Circulation. 2001;104:1029–1033.27.. ### Response: 2001.


Instruction: What is the frequency of permanent pacemaker orimplantsable cardiovdrillator infection in patients?

Output: 335

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the frequency of permanent pacemaker orimplantsable cardiovdrillator infection in patients?. ### Response: 335.


Instruction: What is the frequency of permanent pacemaker infection in patients with gram-negative bacteremia?

Output: Frequency

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the frequency of permanent pacemaker infection in patients with gram-negative bacteremia?. ### Response: Frequency.


Instruction: How many consecutive patients have experienced higher incidence of pacemaker infections after replacement than after first implantation?

Output: 36,076

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many consecutive patients have experienced higher incidence of pacemaker infections after replacement than after first implantation?. ### Response: 36,076.


Instruction: How many consecutive patients were enrolled in Heart Rhythm in 2006?

Output: 36,076

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many consecutive patients were enrolled in Heart Rhythm in 2006?. ### Response: 36,076.


Instruction: What are the implications when reacting to a pulsegenerator change?

Output: Complication risk

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the implications when reacting to a pulsegenerator change?. ### Response: Complication risk.


Instruction: Who is responsible for Complications associated with implantablecardioverter-defibrillator replacement?

Output: device advisories

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is responsible for Complications associated with implantablecardioverter-defibrillator replacement?. ### Response: device advisories.


Instruction: What is the risk associated with pulsegenerator change?

Output: implications when reacting to a device advisory orrecall

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk associated with pulsegenerator change?. ### Response: implications when reacting to a device advisory orrecall.


Instruction: What are implications when reacting to a device advisory or recall?

Output: Complication risk with pulsegenerator change

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are implications when reacting to a device advisory or recall?. ### Response: Complication risk with pulsegenerator change.


Instruction: What is the SAMe-TT2R2 score used to predict?

Output: poor anticoagulation control in AF patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the SAMe-TT2R2 score used to predict?. ### Response: poor anticoagulation control in AF patients.


Instruction: What is a symptom of thromboembolism treated with vitamin K antagonists?

Output: nonvalvular atrial ﬁbrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a symptom of thromboembolism treated with vitamin K antagonists?. ### Response: nonvalvular atrial ﬁbrillation.


Instruction: When was Thrombosis Res published?

Output: 2016

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was Thrombosis Res published?. ### Response: 2016.


Instruction: What is the SAMe-TT2R2 score?

Output: predicts poor anticoagulation control in AF patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the SAMe-TT2R2 score?. ### Response: predicts poor anticoagulation control in AF patients.


Instruction: What are the outcomes in anticoagulated patients with atrial fibrillation?

Output: stroke,clinically relevant bleeding, and mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the outcomes in anticoagulated patients with atrial fibrillation?. ### Response: stroke,clinically relevant bleeding, and mortality.


Instruction: What is the SAME-TT2R2score in patients with atrial fibrillation and cognitive impairment?

Output: the mean time in the therapeutic INR range

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the SAME-TT2R2score in patients with atrial fibrillation and cognitive impairment?. ### Response: the mean time in the therapeutic INR range.


Instruction: What does Lip GY, Haguenoer K, Saint-Etienne C, Fauchier L. Relationship of the SAMe-TT(2)R2 score to poor-quality anticoagulation, stroke,clinically relevant bleeding and mortality in patients?

Output: A prospective validation ofthe SAME-TT2R 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does Lip GY, Haguenoer K, Saint-Etienne C, Fauchier L. Relationship of the SAMe-TT(2)R2 score to poor-quality anticoagulation, stroke,clinically relevant bleeding and mortality in patients?. ### Response: A prospective validation ofthe SAME-TT2R 2.


Instruction: What is the name of the nationwide study in Spain that evaluated the effectiveness of anticoagulation therapy in non-valvular atrial fibrillation?

Output: SAMe-TT2R2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the nationwide study in Spain that evaluated the effectiveness of anticoagulation therapy in non-valvular atrial fibrillation?. ### Response: SAMe-TT2R2.


Instruction: What score predicts poor anticoagulation control in AF patients?

Output: e-TT2R2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What score predicts poor anticoagulation control in AF patients?. ### Response: e-TT2R2.


Instruction: What is a prospective validation of the SAME-TT2R score?

Output: how to identify atrial ﬁbrillation patientswho will have good anticoagulation control on warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a prospective validation of the SAME-TT2R score?. ### Response: how to identify atrial ﬁbrillation patientswho will have good anticoagulation control on warfarin.


Instruction: How does the SAMe-TT2R2 score predict anticoagulation control in AF patients?

Output: poor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does the SAMe-TT2R2 score predict anticoagulation control in AF patients?. ### Response: poor.


Instruction: What is the name of the prospective cohort study?

Output: real-world

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the prospective cohort study?. ### Response: real-world.


Instruction: What are atrial fibrillation patients on?

Output: vitamin K antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are atrial fibrillation patients on?. ### Response: vitamin K antagonists.


Instruction: What does not predict time in therapeutic range of the international normalizedratio in patients attending a high-quality anticoagulation clinic?

Output: SAMeTT(2)R(2)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does not predict time in therapeutic range of the international normalizedratio in patients attending a high-quality anticoagulation clinic?. ### Response: SAMeTT(2)R(2).


Instruction: What does the SAME-TT2R2 score predict in patients with atrial fibrillation and obstructivesleep apnea?

Output: anticoagulationcontrol on VKA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the SAME-TT2R2 score predict in patients with atrial fibrillation and obstructivesleep apnea?. ### Response: anticoagulationcontrol on VKA.


Instruction: What does the SAMe-TT2R2 risk score predict?

Output: poor anticoagulation control in AF patients

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the SAMe-TT2R2 risk score predict?. ### Response: poor anticoagulation control in AF patients.


Instruction: What is a real-world cohort of patients with non-valvular atrial fibrillation on vitamin-K antagonists?

Output: SAMe-TT2R2 risk score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a real-world cohort of patients with non-valvular atrial fibrillation on vitamin-K antagonists?. ### Response: SAMe-TT2R2 risk score.


Instruction: When was the Europace journal published?

Output: 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the Europace journal published?. ### Response: 2015.


Instruction: What are patients with acute venousthromboembolism referred to as?

Output: atrialﬁbrillation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients with acute venousthromboembolism referred to as?. ### Response: atrialﬁbrillation.


Instruction: What is the MAQI2experience?

Output: SAMe-TT 2R2predictsquality of anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the MAQI2experience?. ### Response: SAMe-TT 2R2predictsquality of anticoagulation.


Instruction: When did Vasc Med issue 22(3):197-203?

Output: 2017

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Vasc Med issue 22(3):197-203?. ### Response: 2017.


Instruction: Where can you find instructions for obtaining permission from the American Heart Association?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where can you find instructions for obtaining permission from the American Heart Association?. ### Response: http://www.heart.org/HEARTORG/General/Copyright-Permission-Guidelines_UCM_300404_Article.jsp.


Instruction: What is a link to the “Copyright Permissions Request Form" located on the right side of the page?

Output: American Heart Association

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a link to the “Copyright Permissions Request Form" located on the right side of the page?. ### Response: American Heart Association.


Instruction: What have SRs limited to studies comparing a standard SBP threshold to a more intensive blood pressure threshold in HTN patients arrived at contradicting conclusions based on?

Output: differences in inclusion criteria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What have SRs limited to studies comparing a standard SBP threshold to a more intensive blood pressure threshold in HTN patients arrived at contradicting conclusions based on?. ### Response: differences in inclusion criteria.


Instruction: What did the SR by Saiz et al. (2018) find no benefit of targeting?

Output: an SBP threshold of 130 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the SR by Saiz et al. (2018) find no benefit of targeting?. ### Response: an SBP threshold of 130 mm Hg.


Instruction: What is the SBP threshold of 130 mm Hg?

Output: 150 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the SBP threshold of 130 mm Hg?. ### Response: 150 mm Hg.


Instruction: What does the SR by Weiss et al. look at?

Output: studies targeting a lower threshold

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the SR by Weiss et al. look at?. ### Response: studies targeting a lower threshold.


Instruction: What did Reboussin et al. (2018) find significant reductions in the risk of major cardiovascular events associated with an SBP target of less than 130 mm Hg?

Output: the SR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did Reboussin et al. (2018) find significant reductions in the risk of major cardiovascular events associated with an SBP target of less than 130 mm Hg?. ### Response: the SR.


Instruction: What is the largest individual study to date examining SBP targets?

Output: Systolic Blood Pressure Intervention Trial (SPRINT),

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the largest individual study to date examining SBP targets?. ### Response: Systolic Blood Pressure Intervention Trial (SPRINT),.


Instruction: What is the acronym for the Systolic Blood Pressure Intervention Trial?

Output: SPRINT

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the acronym for the Systolic Blood Pressure Intervention Trial?. ### Response: SPRINT.


Instruction: What age group was included in the SPRINT study?

Output: 50 and over

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What age group was included in the SPRINT study?. ### Response: 50 and over.


Instruction: How much reduction in cardiovascular events did the intensive treatment group show in their cardiovascular events?

Output: 25%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much reduction in cardiovascular events did the intensive treatment group show in their cardiovascular events?. ### Response: 25%.


Instruction: What is the name of the book that discusses the diagnosis of heart failure?

Output: Chronic Heart Failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the book that discusses the diagnosis of heart failure?. ### Response: Chronic Heart Failure.


Instruction: When was the book published?

Output: 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the book published?. ### Response: 2018.


Instruction: What was the purpose of the review?

Output: to establish whether there was any benefit in using an additional diagnostic test

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the purpose of the review?. ### Response: to establish whether there was any benefit in using an additional diagnostic test.


Instruction: How did the committee determine if an additional diagnostic test would be beneficial?

Output: Given the nature of the review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did the committee determine if an additional diagnostic test would be beneficial?. ### Response: Given the nature of the review.


Instruction: What were the process outcomes of the reclassification of specific heart failure aetiology important for?

Output: decision making

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the process outcomes of the reclassification of specific heart failure aetiology important for?. ### Response: decision making.


Instruction: The committee also specified the need for what?

Output: repeat or additional testing

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committee also specified the need for what?. ### Response: repeat or additional testing.


Instruction: What type of evidence was not found?

Output: clinical

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of evidence was not found?. ### Response: clinical.


Instruction: What was the committee concerned about?

Output: Trade -off between clinical benefits and harms  As no randomised controlled studi es were found that addressed the review question, the committee was not able to make a recommendation on the clinical and cost effectiveness of cardiac MRI in heart failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the committee concerned about?. ### Response: Trade -off between clinical benefits and harms  As no randomised controlled studi es were found that addressed the review question, the committee was not able to make a recommendation on the clinical and cost effectiveness of cardiac MRI in heart failure.


Instruction: What was the committee unable to make a recommendation on?

Output: the cost -effectiveness of cardiac MRI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the committee unable to make a recommendation on?. ### Response: the cost -effectiveness of cardiac MRI.


Instruction: What did the committee decide to do?

Output: a research recommendation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee decide to do?. ### Response: a research recommendation.


Instruction: What is added value of cardiac MRI in terms of its clinical and cost effectiveness?

Output: cost and resource implications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is added value of cardiac MRI in terms of its clinical and cost effectiveness?. ### Response: cost and resource implications.


Instruction: What are the reasons discussed below?

Output: clinical and cost effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the reasons discussed below?. ### Response: clinical and cost effectiveness.


Instruction: Trade-off between net clinica l effects and costs?

Output: resource

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Trade-off between net clinica l effects and costs?. ### Response: resource.


Instruction: What was evaluated to evaluate the cost effectiveness of cardiac MRI in patients with heart failure?

Output: No previously published economic evaluations

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was evaluated to evaluate the cost effectiveness of cardiac MRI in patients with heart failure?. ### Response: No previously published economic evaluations.


Instruction: What was presented to the committee?

Output: The cost of a cardiac MRI and echocardiography

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was presented to the committee?. ### Response: The cost of a cardiac MRI and echocardiography.


Instruction: Why was the committee unable to present the cost of MRI and echocardiography?

Output: there was no clinical evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the committee unable to present the cost of MRI and echocardiography?. ### Response: there was no clinical evidence.


Instruction: The committee could not make a judgement on the cost -effectiveness of what?

Output: cardiac MRI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committee could not make a judgement on the cost -effectiveness of what?. ### Response: cardiac MRI.


Instruction: The committee agreed that due to the greater cost of cardiac MRI compared to echocardiography, it was important that an assessment of what was made?

Output: cost -effectiveness of cardiac MRI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The committee agreed that due to the greater cost of cardiac MRI compared to echocardiography, it was important that an assessment of what was made?. ### Response: cost -effectiveness of cardiac MRI.


Instruction: What was included in the research recommendation?

Output: an assessment of the cost -effectiveness

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was included in the research recommendation?. ### Response: an assessment of the cost -effectiveness.


Instruction: What was considered to be an area of high priority for future research?

Output: cardiac MRI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was considered to be an area of high priority for future research?. ### Response: cardiac MRI.


Instruction: What is being increasingly used in heart failure in the UK?

Output: cardiac MRI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is being increasingly used in heart failure in the UK?. ### Response: cardiac MRI.


Instruction: What are significant equality issues around?

Output: access

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are significant equality issues around?. ### Response: access.


Instruction: What is the name of the clinical trial that is currently underway?

Output: OUTSMART255

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the clinical trial that is currently underway?. ### Response: OUTSMART255.


Instruction: What does OUTSMART255 compare outcomes in?

Output: patients randomised to either routine cardiac MRI or selective (clinically driven) cardiac MRI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does OUTSMART255 compare outcomes in?. ### Response: patients randomised to either routine cardiac MRI or selective (clinically driven) cardiac MRI.


Instruction: Who is recruiting patients for the trial?

Output: OUTSMART255

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is recruiting patients for the trial?. ### Response: OUTSMART255.


Instruction: What did the committee consider the results of the trial to be useful in answering?

Output: the question posed in this review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the committee consider the results of the trial to be useful in answering?. ### Response: the question posed in this review.


Instruction: What did the review not answer?

Output: a number of the questions of interest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the review not answer?. ### Response: a number of the questions of interest.


Instruction: What was not answered in the review?

Output: a number of the questions of interest

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not answered in the review?. ### Response: a number of the questions of interest.


Instruction: What is prasugrel used for in an emergency department?

Output: patients withUA/NSTEMI who have not undergone PCI

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is prasugrel used for in an emergency department?. ### Response: patients withUA/NSTEMI who have not undergone PCI.


Instruction: What does the FDA pack-age label suggest?

Output: it is reasonable to consider selectiveuse of prasugrel before catheterization

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the FDA pack-age label suggest?. ### Response: it is reasonable to consider selectiveuse of prasugrel before catheterization.


Instruction: What does the writing group want to warn clinicians about?

Output: potential increased bleeding risks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the writing group want to warn clinicians about?. ### Response: potential increased bleeding risks.


Instruction: What is a potential increase in bleeding?

Output: risks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a potential increase in bleeding?. ### Response: risks.


Instruction: What does the group want to warn clinicians about?

Output: potential increased bleeding risks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does the group want to warn clinicians about?. ### Response: potential increased bleeding risks.


Instruction: Prasugrelor and ticagrelor are compared with which other drug?

Output: clopi-dogrel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Prasugrelor and ticagrelor are compared with which other drug?. ### Response: clopi-dogrel.


Instruction: Why was prasugrel favored over other drugs?

Output: difference in nonfatal MIs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was prasugrel favored over other drugs?. ### Response: difference in nonfatal MIs.


Instruction: What was the main reason for the preference of the P2Y12receptor inhibitors over the other?

Output: efficacy in theprevention of thrombosis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the main reason for the preference of the P2Y12receptor inhibitors over the other?. ### Response: efficacy in theprevention of thrombosis.


Instruction: Why was bleeding increased in the prasumgrel group?

Output: deaths and nonfatal strokes being similar

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was bleeding increased in the prasumgrel group?. ### Response: deaths and nonfatal strokes being similar.


Instruction: The composite efficacy endpoint inTRITON–TIMI 38 favored which drug?

Output: prasugrel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The composite efficacy endpoint inTRITON–TIMI 38 favored which drug?. ### Response: prasugrel.


Instruction: What was the endpoint in PLATO favoring ticagrelor over clopidogrel driven by?

Output: differences in both vasculardeath and nonfatal MIs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the endpoint in PLATO favoring ticagrelor over clopidogrel driven by?. ### Response: differences in both vasculardeath and nonfatal MIs.


Instruction: What was associated with a notable reduction in all-causemortality?

Output: Ticagre-lor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with a notable reduction in all-causemortality?. ### Response: Ticagre-lor.


Instruction: What was associated with a higher rate of non-CABG-related majorbleeding and slightly more frequent discontinuation of the studydrug due to adverse events?

Output: ticagrelor

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was associated with a higher rate of non-CABG-related majorbleeding and slightly more frequent discontinuation of the studydrug due to adverse events?. ### Response: ticagrelor.


Instruction: What did prasugrel have a significant increase in?

Output: the rate of TIMI majorhemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did prasugrel have a significant increase in?. ### Response: the rate of TIMI majorhemorrhage.


Instruction: What is TIMI major and non-CABG bleeding?

Output: hemorrhage

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is TIMI major and non-CABG bleeding?. ### Response: hemorrhage.


Instruction: What was a signifi-cant interaction between the treatment effect in PLATO and thegeographic region?

Output: lack of benefit in the United States forticagrelor versus clopidogrel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a signifi-cant interaction between the treatment effect in PLATO and thegeographic region?. ### Response: lack of benefit in the United States forticagrelor versus clopidogrel.


Instruction: In the United States, forticagrelor versus what drug?

Output: clopidogrel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In the United States, forticagrelor versus what drug?. ### Response: clopidogrel.


Instruction: How many newer P2Y12receptor inhibitors were studied in different patient popula-tions?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many newer P2Y12receptor inhibitors were studied in different patient popula-tions?. ### Response: 2.


Instruction: What is the loading dose of clopidogrel inTRITON–TIMI?

Output: 38

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the loading dose of clopidogrel inTRITON–TIMI?. ### Response: 38.


Instruction: What was the loading dose of clopidogrel inTRITON-TIMI 38 lower than is currently recommended?

Output: 7

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the loading dose of clopidogrel inTRITON-TIMI 38 lower than is currently recommended?. ### Response: 7.


Instruction: Some emerging studies sug-gest there may be some patients who are resistant to what?

Output: clopi-dogrel

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Some emerging studies sug-gest there may be some patients who are resistant to what?. ### Response: clopi-dogrel.


Instruction: What can be used to select patients who might do better with newerP2Y12receptor inhibitors?

Output: strategies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be used to select patients who might do better with newerP2Y12receptor inhibitors?. ### Response: strategies.


Instruction: What are considerations of efficacy in the prevention ofthrombosis?

Output: risk of an adverse effect relatedto bleeding and experience with a given medication

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are considerations of efficacy in the prevention ofthrombosis?. ### Response: risk of an adverse effect relatedto bleeding and experience with a given medication.


Instruction: What was the main outcome of the study?

Output: anticoagulation control

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the main outcome of the study?. ### Response: anticoagulation control.


Instruction: What were the secondary outcomes?

Output: mortality,bleeding, and thromboembolic events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the secondary outcomes?. ### Response: mortality,bleeding, and thromboembolic events.


Instruction: The EtD framework is shown at https://dbep.gradepro.org/profile?

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The EtD framework is shown at https://dbep.gradepro.org/profile?. ### Response: 92492887-D3C0-CAC2-BEEE-D88978A91C30.


Instruction: What is the name of the previous section?

Output: 162

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the previous section?. ### Response: 162.


Instruction: On what date was this section first available?

Output: 21 April 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: On what date was this section first available?. ### Response: 21 April 2023.


Instruction: What was the last section of this section available on?

Output: 3274 WITT et al 27 NOVEMBER 2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the last section of this section available on?. ### Response: 3274 WITT et al 27 NOVEMBER 2018.


Instruction: What is NICE 2018?

Output: Chronic Heart Failure  Monitoring  © NICE 2018. All rights reserved

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NICE 2018?. ### Response: Chronic Heart Failure  Monitoring  © NICE 2018. All rights reserved.


Instruction: What was the ISBN number of the study?

Output: 978 -1-4731 -3093 -7 267

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the ISBN number of the study?. ### Response: 978 -1-4731 -3093 -7 267.


Instruction: How was the economic evidence identified?

Output: No previously published economic evidence was identified for this question in the review.  See also the health economic study  selection flow chart in Appendix  D.   8.3.5 Evidence statements  Clinical  No relevant clinical evidence was identified for inclusion within this review.  Economic  No economic evaluations were identified

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How was the economic evidence identified?. ### Response: No previously published economic evidence was identified for this question in the review.  See also the health economic study  selection flow chart in Appendix  D.   8.3.5 Evidence statements  Clinical  No relevant clinical evidence was identified for inclusion within this review.  Economic  No economic evaluations were identified.


Instruction: What type of evidence was identified for inclusion in the review?

Output: analyses provided a higher quality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of evidence was identified for inclusion in the review?. ### Response: analyses provided a higher quality.


Instruction: What is the health economic study selection flow chart in Appendix D?

Output: 8.3.4

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the health economic study selection flow chart in Appendix D?. ### Response: 8.3.4.


Instruction: What were no economic evaluations identified?

Output: Economic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were no economic evaluations identified?. ### Response: Economic.


Instruction: What is NT -proBNP?

Output: N -terminal pro -B-type natriuretic peptide

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is NT -proBNP?. ### Response: N -terminal pro -B-type natriuretic peptide.


Instruction: Where should you measure NT proBNP as part of a treatment optimisation protocol?

Output: a specialist care setting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where should you measure NT proBNP as part of a treatment optimisation protocol?. ### Response: a specialist care setting.


Instruction: What is the eGFR of people with heart failure above 60 ml/min/1.73 m2?

Output: reduced ejection fraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the eGFR of people with heart failure above 60 ml/min/1.73 m2?. ### Response: reduced ejection fraction.


Instruction: What were the critical outc omes identified as?

Output: mortality, all -cause hospitalisations and quality of life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the critical outc omes identified as?. ### Response: mortality, all -cause hospitalisations and quality of life.


Instruction: How were the relative values of different outcomes identified?

Output: mortality, all -cause hospitalisations and quality of life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How were the relative values of different outcomes identified?. ### Response: mortality, all -cause hospitalisations and quality of life.


Instruction: What were outc omes identified as?

Output: mortality, all -cause hospitalisations and quality of life

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were outc omes identified as?. ### Response: mortality, all -cause hospitalisations and quality of life.


Instruction: What were all-cause hospitalisations and quality of life?

Output: mortality

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were all-cause hospitalisations and quality of life?. ### Response: mortality.


Instruction: What was expected that older people may not respond as well to more intensive treatment regimes?

Output: on average

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was expected that older people may not respond as well to more intensive treatment regimes?. ### Response: on average.


Instruction: What did the review identify multiple existing meta - analyses that pooled data from?

Output: a number of heterogeneous trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the review identify multiple existing meta - analyses that pooled data from?. ### Response: a number of heterogeneous trials.


Instruction: How many meta -analyses did there exist?

Output: multiple

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many meta -analyses did there exist?. ### Response: multiple.


Instruction: What was used in two of the existing me ta analyses?

Output: individual patient data (IPD)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was used in two of the existing me ta analyses?. ### Response: individual patient data (IPD).


Instruction: How did the use of IPD compare to the data reported by other studies?

Output: higher quality source of evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did the use of IPD compare to the data reported by other studies?. ### Response: higher quality source of evidence.


Instruction: How did this review use data from the existing IPD meta -analyses?

Output: where possible

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did this review use data from the existing IPD meta -analyses?. ### Response: where possible.


Instruction: What were the differences in the trials included in the existing meta analyses?

Output: patient population, baseline medication, NP guided protocol and control arm protocol

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the differences in the trials included in the existing meta analyses?. ### Response: patient population, baseline medication, NP guided protocol and control arm protocol.


Instruction: How did the trials differ in patient population, baseline medication, NP guided protocol and control arm protocol?

Output: differed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How did the trials differ in patient population, baseline medication, NP guided protocol and control arm protocol?. ### Response: differed.


Instruction: What was unable to formally assess the heterogeneity of the results split by age due to reliance on aggregate data from one of the existing meta -analyses?

Output: The review

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was unable to formally assess the heterogeneity of the results split by age due to reliance on aggregate data from one of the existing meta -analyses?. ### Response: The review.


Instruction: What gave the committee some confidence that considering the trials together was a valid approach?

Output: the l ow levels of heterogeneity in the overall (not age -stratified) results

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What gave the committee some confidence that considering the trials together was a valid approach?. ### Response: the l ow levels of heterogeneity in the overall (not age -stratified) results.


Instruction: What did levels of heterogeneity in the results give the committee?

Output: some confidence that considering the trials together was a valid approach

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did levels of heterogeneity in the results give the committee?. ### Response: some confidence that considering the trials together was a valid approach.


Instruction: Meschia et al Guidelines for the Primary Prevention of Stroke 3823 576 What is associated with stroke in sickle cell disease?

Output: Plasma interleukin-1beta concentration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Meschia et al Guidelines for the Primary Prevention of Stroke 3823 576 What is associated with stroke in sickle cell disease?. ### Response: Plasma interleukin-1beta concentration.


Instruction: What is the plasma interleukin-1beta concentration?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the plasma interleukin-1beta concentration?. ### Response: stroke.


Instruction: What is the name of the disease that causes sickle cell disease?

Output: anaemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease that causes sickle cell disease?. ### Response: anaemia.


Instruction: What are the results of genetic dissection and prognostic modeling of overt stroke?

Output: silent cerebral infarcts and glucose-6-phos-phate dehydrogenase mutation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the results of genetic dissection and prognostic modeling of overt stroke?. ### Response: silent cerebral infarcts and glucose-6-phos-phate dehydrogenase mutation.


Instruction: What is STOP?

Output: Stroke Prevention Trial in Sickle Cell Anemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is STOP?. ### Response: Stroke Prevention Trial in Sickle Cell Anemia.


Instruction: What promoter polymorphism is associated with stroke risk in children with sickle cell anemia?

Output: TNF(-308)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What promoter polymorphism is associated with stroke risk in children with sickle cell anemia?. ### Response: TNF(-308).


Instruction: Stroke. 2007;38:2241–2246. 579

Output: Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Stroke. 2007;38:2241–2246. 579. ### Response: Stroke.


Instruction: What are genetic predictors for stroke in children with sickle cell anemia?

Output: TNF(-308) promoter polymorphism

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are genetic predictors for stroke in children with sickle cell anemia?. ### Response: TNF(-308) promoter polymorphism.


Instruction: When did Blood. 2011;117:6681-6684.

Output: 580

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Blood. 2011;117:6681-6684.. ### Response: 580.


Instruction: What is the name of the disease that causes stroke in sickle cells?

Output: anemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the disease that causes stroke in sickle cells?. ### Response: anemia.


Instruction: What is associated with silent cerebral infarcts and glucose-6-phos-phate dehydrogenase?

Output: Magnetic resonance angiography-defined intracranial vas-culopathy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with silent cerebral infarcts and glucose-6-phos-phate dehydrogenase?. ### Response: Magnetic resonance angiography-defined intracranial vas-culopathy.


Instruction: What is vas-culopathy associated with in children with sickle cell anaemia?

Output: silent cerebral infarcts and glucose-6-phos-phate dehydrogenase mutation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is vas-culopathy associated with in children with sickle cell anaemia?. ### Response: silent cerebral infarcts and glucose-6-phos-phate dehydrogenase mutation.


Instruction: What is a mutation in glucose-6-phos-phate dehydrogenase?

Output: Magnetic resonance angiography-defined intracranial vas-culopathy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a mutation in glucose-6-phos-phate dehydrogenase?. ### Response: Magnetic resonance angiography-defined intracranial vas-culopathy.


Instruction: In what year did Br J Haematol publish 159:352–359.

Output: 2012

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what year did Br J Haematol publish 159:352–359.. ### Response: 2012.


Instruction: In which year did Blood publish 81:1109-1123?

Output: 1993

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In which year did Blood publish 81:1109-1123?. ### Response: 1993.


Instruction: What is the name of the multi-center transfusion trial?

Output: STOP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the multi-center transfusion trial?. ### Response: STOP.


Instruction: When was the 23rd Annual Meeting of the National Sickle Cell Disease Program held?

Output: March 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was the 23rd Annual Meeting of the National Sickle Cell Disease Program held?. ### Response: March 1999.


Instruction: What city is home to the National Heart, Lung, and Blood Institute?

Output: San Francisco

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What city is home to the National Heart, Lung, and Blood Institute?. ### Response: San Francisco.


Instruction: When did the NHLBI stop testing how long children with sickle cell anemia should have blood transfusions to prevent stroke?

Output: December 5, 2004

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did the NHLBI stop testing how long children with sickle cell anemia should have blood transfusions to prevent stroke?. ### Response: December 5, 2004.


Instruction: What year was San Francisco, CA?

Output: 1999

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was San Francisco, CA?. ### Response: 1999.


Instruction: Where is San Francisco located?

Output: CA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where is San Francisco located?. ### Response: CA.


Instruction: What is the name of the STOP 2 Trial Investigators?

Output: Optimizing Primary Stroke Prevention in Sickle Cell Anemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the STOP 2 Trial Investigators?. ### Response: Optimizing Primary Stroke Prevention in Sickle Cell Anemia.


Instruction: What is used to prevent stroke in sickle cell disease?

Output: Blood Transfusions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used to prevent stroke in sickle cell disease?. ### Response: Blood Transfusions.


Instruction: How does stopping prophylactic transfusions increase the risk of stroke?

Output: risk of silent brain infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How does stopping prophylactic transfusions increase the risk of stroke?. ### Response: risk of silent brain infarction.


Instruction: What increases the risk of silent brain infarction in children with sickle cell disease?

Output: Discontinuing prophylactic transfusions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What increases the risk of silent brain infarction in children with sickle cell disease?. ### Response: Discontinuing prophylactic transfusions.


Instruction: What does discontinuing prophylactic transfusions increase?

Output: the risk of silent brain infarction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does discontinuing prophylactic transfusions increase?. ### Response: the risk of silent brain infarction.


Instruction: Blood. 2011;118:894-898. 586.

Output: Gulbis

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Blood. 2011;118:894-898. 586.. ### Response: Gulbis.


Instruction: What is the name of the person who was a part of the team that worked on the project?

Output: Adams RJ

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the person who was a part of the team that worked on the project?. ### Response: Adams RJ.


Instruction: What was the title of the project that was involved in the development of the program?

Output: STOP II Study Investigators

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the title of the project that was involved in the development of the program?. ### Response: STOP II Study Investigators.


Instruction: Who was the author of the report?

Output: Meschia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who was the author of the report?. ### Response: Meschia.


Instruction: What is an underlyingprinciple of procedural sedation?

Output: the physician shouldbe prepared to manage one level of sedation deeper than thelevel intended

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an underlyingprinciple of procedural sedation?. ### Response: the physician shouldbe prepared to manage one level of sedation deeper than thelevel intended.


Instruction: What should cardiologists be cognizant of?

Output: theprinciples of managing deep sedation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should cardiologists be cognizant of?. ### Response: theprinciples of managing deep sedation.


Instruction: What is the VA/DoD Clinical Practice Guideline for the Diagnosis and Management of Hypertension in the Primary Care Setting?

Output: Page 83 of 134 Appendix B: Patient Focus Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the VA/DoD Clinical Practice Guideline for the Diagnosis and Management of Hypertension in the Primary Care Setting?. ### Response: Page 83 of 134 Appendix B: Patient Focus Group.


Instruction: How many pages are in the Appendix B: Patient Focus Group Methods and Findings?

Output: 134

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many pages are in the Appendix B: Patient Focus Group Methods and Findings?. ### Response: 134.


Instruction: What was the purpose of the patient focus group?

Output: Provide comprehensive information and education

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the purpose of the patient focus group?. ### Response: Provide comprehensive information and education.


Instruction: Where was the focus group held?

Output: Naval Medical Center in San Diego, CA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Where was the focus group held?. ### Response: Naval Medical Center in San Diego, CA.


Instruction: What was held on January 23rd, 2019?

Output: patient focus group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was held on January 23rd, 2019?. ### Response: patient focus group.


Instruction: What was the goal of the focus group?

Output: eliciting a range of perspectives likely to be relevant and informative in the guideline development process

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the goal of the focus group?. ### Response: eliciting a range of perspectives likely to be relevant and informative in the guideline development process.


Instruction: Who were the most affected by the recommendations put forth in the CPG?

Output: DoD healthcare systems

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who were the most affected by the recommendations put forth in the CPG?. ### Response: DoD healthcare systems.


Instruction: What were the patients’ perspectives?

Output: their priorities, challenges they have experienced, the information they received regarding their care, as well as the impacts of their care on their lives

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the patients’ perspectives?. ### Response: their priorities, challenges they have experienced, the information they received regarding their care, as well as the impacts of their care on their lives.


Instruction: What did the CPG focus on?

Output: HTN management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the CPG focus on?. ### Response: HTN management.


Instruction: What was the focus group able to dive into the patients' perspectives?

Output: a set of topics related to their HTN management

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the focus group able to dive into the patients' perspectives?. ### Response: a set of topics related to their HTN management.


Instruction: Who recruited the focus group participants?

Output: VA and DoD Leadership

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who recruited the focus group participants?. ### Response: VA and DoD Leadership.


Instruction: What was not intended to be a representative sample of VA and DoD patients?

Output: Patient focus group participants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not intended to be a representative sample of VA and DoD patients?. ### Response: Patient focus group participants.


Instruction: What did recruitment focus on?

Output: eliciting a range of perspectives likely to be relevant and informative in the guideline development process

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did recruitment focus on?. ### Response: eliciting a range of perspectives likely to be relevant and informative in the guideline development process.


Instruction: What was not incentivized for their participation or reimbursed for?

Output: travel expenses

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not incentivized for their participation or reimbursed for?. ### Response: travel expenses.


Instruction: What did CPG Champions and Work Group develop to help guide the focus group?

Output: a set of questions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did CPG Champions and Work Group develop to help guide the focus group?. ### Response: a set of questions.


Instruction: What did the facilitator use as a general guide to elicit the most important information from the patients?

Output: previously prepared questions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the facilitator use as a general guide to elicit the most important information from the patients?. ### Response: previously prepared questions.


Instruction: What did not all of the listed questions be addressed?

Output: Given the limited time and the range of inter ests of the focus group participants

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did not all of the listed questions be addressed?. ### Response: Given the limited time and the range of inter ests of the focus group participants.


Instruction: What did the focus group participants provide?

Output: comprehensive information and education

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the focus group participants provide?. ### Response: comprehensive information and education.


Instruction: What is one way to provide comprehensive information and education to patients regarding their condition, management strategies, and self-management?

Output: expanding available information on complementary and alternative therapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one way to provide comprehensive information and education to patients regarding their condition, management strategies, and self-management?. ### Response: expanding available information on complementary and alternative therapies.


Instruction: What would patients like to be offered educational materials?

Output: pamphlets

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What would patients like to be offered educational materials?. ### Response: pamphlets.


Instruction: What did some patients feel that their providers did not offer the full range of management options?

Output: seemed to prioritize pharmacologic interventions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did some patients feel that their providers did not offer the full range of management options?. ### Response: seemed to prioritize pharmacologic interventions.


Instruction: What did patients note that there were many non pharmacological management strategies?

Output: Tai Chi, yoga, meditation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did patients note that there were many non pharmacological management strategies?. ### Response: Tai Chi, yoga, meditation.


Instruction: What non-pharmacological management strategies were not offered to the patients?

Output: Tai Chi, yoga, meditation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What non-pharmacological management strategies were not offered to the patients?. ### Response: Tai Chi, yoga, meditation.


Instruction: What did some of the patients feel their providers did not consider?

Output: all of their individual, unique characteristics that could impact their high blood pressure and management strategies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did some of the patients feel their providers did not consider?. ### Response: all of their individual, unique characteristics that could impact their high blood pressure and management strategies.


Instruction: What did some patien ts say they didn't receive information on?

Output: the harms of having high

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did some patien ts say they didn't receive information on?. ### Response: the harms of having high.


Instruction: What could impact their high blood pressure?

Output: unique characteristics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What could impact their high blood pressure?. ### Response: unique characteristics.


Instruction: What is a Key Question Specif ic Criteria?

Output: Literature Search Strategy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a Key Question Specif ic Criteria?. ### Response: Literature Search Strategy.


Instruction: What is the Literature Search Strategy?

Output: Key Question Specif ic Criteria  .................................................................................................... 74 c. Literature Search Strategy  ......................................................................................................... 75 C. Convening the Face -to-face Meeting

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the Literature Search Strategy?. ### Response: Key Question Specif ic Criteria  .................................................................................................... 74 c. Literature Search Strategy  ......................................................................................................... 75 C. Convening the Face -to-face Meeting.


Instruction: How are Recommendations categorized?

Output: Categories and Definitions  .......................................................................... 79 b. Categorizing Recommendations with an Updated Review of the Evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How are Recommendations categorized?. ### Response: Categories and Definitions  .......................................................................... 79 b. Categorizing Recommendations with an Updated Review of the Evidence.


Instruction: What is an Appendix B: Patient Focus Group Methods and Procedures?

Output: 81 Appendix B:  Patient Focus Group Methods and Findings

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an Appendix B: Patient Focus Group Methods and Procedures?. ### Response: 81 Appendix B:  Patient Focus Group Methods and Findings.


Instruction: What is a Definition?

Output: Recommendation Categories and Definitions

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a Definition?. ### Response: Recommendation Categories and Definitions.


Instruction: What is the name of the Appendix B: Patient Focus Group Methods and Findings?

Output: 83

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the Appendix B: Patient Focus Group Methods and Findings?. ### Response: 83.


Instruction: What is one of the ways to provide comprehensive info rmation and education to patients regarding their condition?

Output: expanding available information on complementary and alternative therapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the ways to provide comprehensive info rmation and education to patients regarding their condition?. ### Response: expanding available information on complementary and alternative therapies.


Instruction: Self-management, including expanding available information on what?

Output: complementary and alternative therapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Self-management, including expanding available information on what?. ### Response: complementary and alternative therapies.


Instruction: Improve the method of measuring what in the office?

Output: blood pressure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Improve the method of measuring what in the office?. ### Response: blood pressure.


Instruction: How many hospital admissions for stroke were for stroke patients 80 years of age?

Output: one third

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many hospital admissions for stroke were for stroke patients 80 years of age?. ### Response: one third.


Instruction: What percentage of men with AF were identified as having AF?

Output: 47.2%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of men with AF were identified as having AF?. ### Response: 47.2%).


Instruction: How many men and women had AF?

Output: 15.6%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many men and women had AF?. ### Response: 15.6%.


Instruction: How many women with AF had it?

Output: 1569

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many women with AF had it?. ### Response: 1569.


Instruction: What is the risk stratification of AF for women?

Output: ≥75 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the risk stratification of AF for women?. ### Response: ≥75 years.


Instruction: Who is less likely to receive anticoagulation therapy?

Output: women with AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who is less likely to receive anticoagulation therapy?. ### Response: women with AF.


Instruction: What is one of the most feared compli-cations in patients with AF?

Output: stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is one of the most feared compli-cations in patients with AF?. ### Response: stroke.


Instruction: What are useful in guiding the decision making for anticoagulation therapy?

Output: Risk stratification tools

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are useful in guiding the decision making for anticoagulation therapy?. ### Response: Risk stratification tools.


Instruction: How many points does the CHADS2 score give for congestive heart failure?

Output: 1 point

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many points does the CHADS2 score give for congestive heart failure?. ### Response: 1 point.


Instruction: What is the chads2 score for diabetes mellitus?

Output: 1 point

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the chads2 score for diabetes mellitus?. ### Response: 1 point.


Instruction: In addition to diabetes, how many points is given for prior stroke/TIA?

Output: 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In addition to diabetes, how many points is given for prior stroke/TIA?. ### Response: 2.


Instruction: What is an independent predictor of stroke in AF patients?

Output: Female sex

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an independent predictor of stroke in AF patients?. ### Response: Female sex.


Instruction: What is a score of 0 points indicating low risk?

Output: 0.5% to 1.7%);

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a score of 0 points indicating low risk?. ### Response: 0.5% to 1.7%);.


Instruction: What is an independent predictor of stroke in patients with AF?

Output: Female sex

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an independent predictor of stroke in patients with AF?. ### Response: Female sex.


Instruction: What can be considered an exten-sion of the CHADS2 with extra points added for female sex?

Output: A2DS2-V ASc score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be considered an exten-sion of the CHADS2 with extra points added for female sex?. ### Response: A2DS2-V ASc score.


Instruction: How many extra points were added to CHADS2 for female sex?

Output: 1 point

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many extra points were added to CHADS2 for female sex?. ### Response: 1 point.


Instruction: How many points added for previous MI, peripheral arterial disease or aortic plaque?

Output: 1 point

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many points added for previous MI, peripheral arterial disease or aortic plaque?. ### Response: 1 point.


Instruction: What did the American College of Cardiology/AHA/European Society of cardiology guidelines include?

Output: similar risk strati-fication strategies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the American College of Cardiology/AHA/European Society of cardiology guidelines include?. ### Response: similar risk strati-fication strategies.


Instruction: What did the European Society of Cardiology recommend for risk classification?

Output: ASc score

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the European Society of Cardiology recommend for risk classification?. ### Response: ASc score.


Instruction: How many large cohort studies have both confirmed an age-sex interaction?

Output: Two

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many large cohort studies have both confirmed an age-sex interaction?. ### Response: Two.


Instruction: What percentage of ejection fraction was included in the high-risk category?

Output: <35%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of ejection fraction was included in the high-risk category?. ### Response: <35%.


Instruction: What has been confirmed in large cohort studies?

Output: an age-sex interaction in patients with AF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has been confirmed in large cohort studies?. ### Response: an age-sex interaction in patients with AF.


Instruction: What suggests a higher risk of stroke in women 75 years with AF compared with men?

Output: age-sex interaction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What suggests a higher risk of stroke in women 75 years with AF compared with men?. ### Response: age-sex interaction.


Instruction: How many patients with nonvalvular AF were included in a large study in Sweden?

Output: 100 802

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with nonvalvular AF were included in a large study in Sweden?. ### Response: 100 802.


Instruction: What was the incident risk of IS greater in women with AF in Sweden than in men?

Output: 6.2% versus 4.2% per year

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the incident risk of IS greater in women with AF in Sweden than in men?. ### Response: 6.2% versus 4.2% per year.


Instruction: What percentage of men had nonvalvular AF and 44 115 women had AF from Canada?

Output: 47.2%)

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of men had nonvalvular AF and 44 115 women had AF from Canada?. ### Response: 47.2%).


Instruction: Who showed a higher crude stroke incidence in women than men?

Output: Canada

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who showed a higher crude stroke incidence in women than men?. ### Response: Canada.


Instruction: What was the stroke incidence per 100 person-year among participants with AF from Canada?

Output: 2.02

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the stroke incidence per 100 person-year among participants with AF from Canada?. ### Response: 2.02.


Instruction: What was the stroke incidence per 100 person-year among participants aged  75 years?

Output: 2.38

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the stroke incidence per 100 person-year among participants aged  75 years?. ### Response: 2.38.


Instruction: How many episodes of AF recurrence are symptomatic?

Output: 1 in every 12 paroxysms

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many episodes of AF recurrence are symptomatic?. ### Response: 1 in every 12 paroxysms.


Instruction: How many series suggest that only 1 in every 12 paroxysms are what?

Output: 1

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many series suggest that only 1 in every 12 paroxysms are what?. ### Response: 1.


Instruction: For patients with AF of greater than 48 h or unknown duration undergoing elective electrical orpharmacologic cardioversion, what is recommended?

Output: therapeutic anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For patients with AF of greater than 48 h or unknown duration undergoing elective electrical orpharmacologic cardioversion, what is recommended?. ### Response: therapeutic anticoagulation.


Instruction: What should be strongly emphasized with NOACs?

Output: adherence and persistences

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be strongly emphasized with NOACs?. ### Response: adherence and persistences.


Instruction: What should patients with AF of greater than 48 h or unknown duration undergo before cardioversion?

Output: elective electrical orpharmacologic cardioversion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients with AF of greater than 48 h or unknown duration undergo before cardioversion?. ### Response: elective electrical orpharmacologic cardioversion.


Instruction: What type of anticoagulation is recommended for patients with AF of greater than 48 h?

Output: therapeutic

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of anticoagulation is recommended for patients with AF of greater than 48 h?. ### Response: therapeutic.


Instruction: What is the baseline risk of stroke?

Output: >48 h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the baseline risk of stroke?. ### Response: >48 h.


Instruction: What should decisions about anticoagulation after 4 weeks be made in accordance with?

Output: our risk-based recommendations for long-term antithrombotictherapy in recommendations 1 and 2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should decisions about anticoagulation after 4 weeks be made in accordance with?. ### Response: our risk-based recommendations for long-term antithrombotictherapy in recommendations 1 and 2.


Instruction: What should not be made on thebasis of successful cardioversion?

Output: Decisions about anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not be made on thebasis of successful cardioversion?. ### Response: Decisions about anticoagulation.


Instruction: What should be individualized?

Output: a decision onwhether a repeat TEE is performed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be individualized?. ### Response: a decision onwhether a repeat TEE is performed.


Instruction: How long is cardioversion of AF necessary for development of thrombus?

Output: 4-12 weeks

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long is cardioversion of AF necessary for development of thrombus?. ### Response: 4-12 weeks.


Instruction: Theduration of AF necessary for development of thrombusis not clear.

Output: >48 h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Theduration of AF necessary for development of thrombusis not clear.. ### Response: >48 h.


Instruction: What is not known?

Output: the threshold of AF duration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not known?. ### Response: the threshold of AF duration.


Instruction: What can be avoided if AF is of short duration?

Output: pre-cardioversion anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can be avoided if AF is of short duration?. ### Response: pre-cardioversion anticoagulation.


Instruction: What is the duration of AF?

Output: <48 h

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the duration of AF?. ### Response: <48 h.


Instruction: What percentage of patients with AF of short duration have left atrialthrombus on TEE in observational studies?

Output: 14%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients with AF of short duration have left atrialthrombus on TEE in observational studies?. ### Response: 14%.


Instruction: What should patients be managed as if AF >48 h?

Output: If there is uncertainty about precise time of AF onset

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should patients be managed as if AF >48 h?. ### Response: If there is uncertainty about precise time of AF onset.


Instruction: How many successfulcardioversions were performed in 2,481 patients with acute AF?

Output: 5,116

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many successfulcardioversions were performed in 2,481 patients with acute AF?. ### Response: 5,116.


Instruction: What was the low incidence of stroke/thromboembolism during 30 days following cardioversion?

Output: 0.7%).

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the low incidence of stroke/thromboembolism during 30 days following cardioversion?. ### Response: 0.7%)..


Instruction: How many days after cardioversion is there a lower incidence of stroke/thromboembolism?

Output: 30

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many days after cardioversion is there a lower incidence of stroke/thromboembolism?. ### Response: 30.


Instruction: What percentage of patients with a CHA2DS2-VASc score have perioperative anticoagulation?

Output: 0.7%).

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients with a CHA2DS2-VASc score have perioperative anticoagulation?. ### Response: 0.7%)..


Instruction: What is an alternative to ICD?

Output: wearable  cardioverter-defibrillator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an alternative to ICD?. ### Response: wearable  cardioverter-defibrillator.


Instruction: What do patients with an ICD receive?

Output: heart trans-plant suggest improved survival

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What do patients with an ICD receive?. ### Response: heart trans-plant suggest improved survival.


Instruction: What is an alternative to ICD in this population?

Output: the wearable  cardioverter-defibrillator

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an alternative to ICD in this population?. ### Response: the wearable  cardioverter-defibrillator.


Instruction: What is a wearable cardioverter-defibrillator?

Output: S7.7.1-2,S7.7.1-3

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a wearable cardioverter-defibrillator?. ### Response: S7.7.1-2,S7.7.1-3.


Instruction: What are patients who remain hospitalized with no intention to discharge home until transplant occurs?

Output: HFr EF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are patients who remain hospitalized with no intention to discharge home until transplant occurs?. ### Response: HFr EF.


Instruction: What is the decision to place an ICD independent of?

Output: whether they are awaiting heart transplant

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the decision to place an ICD independent of?. ### Response: whether they are awaiting heart transplant.


Instruction: What percentage of patients with HF have a preserved LVEF?

Output: Nearly half

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of patients with HF have a preserved LVEF?. ### Response: Nearly half.


Instruction: What type of patients tend to be older and have more comorbidities than patients with heart transplant?

Output: HF With Preserved Ejection Fraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of patients tend to be older and have more comorbidities than patients with heart transplant?. ### Response: HF With Preserved Ejection Fraction.


Instruction: Patients with HFr EF tend to be older and have more comorbidities than patients with what?

Output: HF With Preserved Ejection Fraction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Patients with HFr EF tend to be older and have more comorbidities than patients with what?. ### Response: HF With Preserved Ejection Fraction.


Instruction: SCD is lower in patients with which type of ejection fraction?

Output: HF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: SCD is lower in patients with which type of ejection fraction?. ### Response: HF.


Instruction: About a quarter of all deaths among patients with who are sudden?

Output: HFp EF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: About a quarter of all deaths among patients with who are sudden?. ### Response: HFp EF.


Instruction: What percentage of deaths among patients with HFp EF are sudden?

Output: nearly a quarter

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of deaths among patients with HFp EF are sudden?. ### Response: nearly a quarter.


Instruction: What is the challenge in preventing SCD in HF-pEF patients?

Output: identifying which patients are at a high enough risk to benefit from preventive therapies

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the challenge in preventing SCD in HF-pEF patients?. ### Response: identifying which patients are at a high enough risk to benefit from preventive therapies.


Instruction: SCD in patients with HFp EF do not identify what?

Output: consistent factors

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: SCD in patients with HFp EF do not identify what?. ### Response: consistent factors.


Instruction: There is no accepted noninvasive test to identify high-risk patients with what type of EF?

Output: HFp

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is no accepted noninvasive test to identify high-risk patients with what type of EF?. ### Response: HFp.


Instruction: Invasive risk stratification with an electrophysiological study shows promise in what population?

Output: HFp EF

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Invasive risk stratification with an electrophysiological study shows promise in what population?. ### Response: HFp EF.


Instruction: In what trial is risk strati-fication in patients with preserved ejection fraction being studied?

Output: NCT02124018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In what trial is risk strati-fication in patients with preserved ejection fraction being studied?. ### Response: NCT02124018.


Instruction: What was carefully considered by the writing committee?

Output: Whether to include a recommendation related to an electrophysiological study in patients with HFpEF and ischemic heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was carefully considered by the writing committee?. ### Response: Whether to include a recommendation related to an electrophysiological study in patients with HFpEF and ischemic heart disease.


Instruction: What was considered insufficient to support a formal recommendation?

Output: evidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was considered insufficient to support a formal recommendation?. ### Response: evidence.


Instruction: What can reasonably be considered in select patients with HFpEF and ischemic heart disease?

Output: the pros and cons of an electrophysiological study

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What can reasonably be considered in select patients with HFpEF and ischemic heart disease?. ### Response: the pros and cons of an electrophysiological study.


Instruction: Who are experiencing symp-toms suggestive of a VA?

Output: patients with HFpEF and ischemic heart disease

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Who are experiencing symp-toms suggestive of a VA?. ### Response: patients with HFpEF and ischemic heart disease.


Instruction: When was this downloaded from http://ahajournals.org?

Output: April 23, 2023

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When was this downloaded from http://ahajournals.org?. ### Response: April 23, 2023.


Instruction: Dabigatran, rivaroxaban, andedoxaban may be associated with more GI bleeding than what?

Output: VKA

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Dabigatran, rivaroxaban, andedoxaban may be associated with more GI bleeding than what?. ### Response: VKA.


Instruction: Poor compliance VKA INR monitoring can help to detect problems.

Output: bleeding

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Poor compliance VKA INR monitoring can help to detect problems.. ### Response: bleeding.


Instruction: What does UFH infusion have more experience with in patients treated withthrombolytic therapy?

Output: its use

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does UFH infusion have more experience with in patients treated withthrombolytic therapy?. ### Response: its use.