In the case of new combinations of known substances which have been investigated in accordance with the provisions of this Directive, the repeat-dose tests may, except where toxicity tests have demonstrated potentiation or novel toxic effects, be suitably modified by the investigator, who shall submit his reasons for such modifications.
I gcás teaglaim nua de shubstaintí aitheanta a ndearnadh imscrúdú orthu i gcomhréir le forálacha na Treorach seo, féadfaidh an t-imscrúdaitheoir na tástálacha ildáileoige a athrú go hoiriúnach, ach amháin i gcás inar léirigh tástálacha tocsaineolaíocha neartaitheacht nó éifeachtaí tocsaineacha nua, agus soláthróidh an t-imscrúdaitheoir na cúiseanna leis an athrú sin.