mnli premise: On one grand boulevard, the Paseo del Prado, are three of Europe's finest  the world-class Prado museum, the Thyssen-Bornemisza collection, and the Centro de Arte Reina Sof?­a (Queen Sof?­a Art Ceter), whose claim to fame is the 20th century's most famous painting, Pablo Picasso's Guernica. hypothesis: One of the most famous 20th century's painting is held in the Centro de Arte Reina Sofia.