qnli question: In practice, Pre-Columbian refers to the history of the indigenous cultures of America prior to Europeans doing what to them? sentence: "Pre-Columbian" is used especially often in the context of discussing the great indigenous civilizations of the Americas, such as those of Mesoamerica (the Olmec, the Toltec, the Teotihuacano, the Zapotec, the Mixtec, the Aztec, and the Maya civilizations) and those of the Andes (Inca Empire, Moche culture, Muisca Confederation, Cañaris).