qnli question: When was the reign of sultan Mehmed VI? sentence: As such, the last Ottoman sultan Mehmed VI (r. 1918–1922) was a direct patrilineal (male-line) descendant of the first Ottoman sultan Osman I (r. 1299–1326), which was unparallelled in both Europe (e.g. the male line of the House of Habsburg became extinct in 1740) and in the Islamic world.