***Background.*** Healthcare associated infections negatively impact patient outcomes and increase healthcare costs. Interventions have focused on specific risk factors, the presence or absence of indwelling urinary catheter for example, and interventions that could be applied across broadly have been limited. Following the publication of the experience with Chlorhexidine bathing on central line infections and MDRO acquisition in critically ill and bone marrow populations, we sought to examine the impact of this intervention on CLA-BSI, CA-UTI, and MDRO acquisition when applied to patients in both critical and acute care.

***Methods.*** This qausi-experimental study examined the impact of CHG-bathing to all patients (1) in an adult critical care unit or (2) on an acute care floor if the patient had a central line, indwelling urinary catheter, or colonized with CRE. At the request of the stem cell attending, allogeneic bone marrow transplant patients were excluded. The rate of device related infections where compared pre and post intervention.

***Results.*** For CAUTI, The average monthly rate per 1,000 IUC days fell from 4.3 prior to HG bathing to 2.8 post implementation (p-value \<0.001). For CLA-BSI, the average rate for the whole hospital declined from 3.2/1,000 central line days to 0.88/1,000 central line days (p-value \<0.001). MDRO transmission is still being analyzed.

***Conclusion.*** CHG bathing throughout the hospital setting targeting at patient with specific risk factors was associated with a marked decline in both our CA-UTI and CLA-BSI rate. Analysis of this trend over time and a dose response are pending.

***Disclosures.*** **All authors:** No reported disclosures.

[^1]: **Session:** 111. Device-Associated HAIs

[^2]: Friday, October 10, 2014: 12:30 PM
