Introduction {#sec1_1}
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Pseudolymphomatous folliculitis (PLF) was first described as a variant of pseudolymphoma. It is characterized by a dense lymphoid infiltrate accompanied by hyperplastic hair follicles \[[@B1], [@B2]\]. Clinically, PLF is sometimes difficult to differentiate from primary malignant cutaneous lymphomas that may present as solitary nodules. A diagnosis of PLF is made based on hypertrophic hair follicles, perifollicular S100+ and CD1a+ dendritic cells, and negative clonal gene rearrangement study findings \[[@B2], [@B3]\]. However, sometimes it takes a long time to achieve the final diagnosis. In this report, we present the characteristic dermoscopic features of PLF based on the typical histological features.

Case Report {#sec1_2}
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A 45-year-old Japanese woman visited our outpatient clinic with a two-month history of a developing, asymptomatic nodule on her nose. On her initial visit, physical examination revealed a red, dome-shaped nodule, 15 × 14 mm in size on the right side of her nose (**fig. [1a](#F1){ref-type="fig"}**). Dermoscopy revealed prominent multiple perifollicular and follicular yellowish spots, follicular red dots, and arborizing vessels (fig. [1b](#F1){ref-type="fig"}). A biopsy specimen showed a dense lymphocytic infiltrate containing numerous histiocytes that surrounded and infiltrated hypertrophic hair follicles (**fig. [2a](#F2){ref-type="fig"}**). The infiltrate was separated from the epidermis by a grenz zone (fig. [2b](#F2){ref-type="fig"}). There was no reactive pattern in follicular centers. Infiltrated cells were medium-sized with a high nuclear/cytoplasmic ratio and prominant nucleoli (fig. [2b](#F2){ref-type="fig"}). Immunohistochemical staining revealed that the infiltrate consisted of a mixed population of B (CD79a+) and T (CD2+, CD3+, CD4+, CD5+, and CD7+) lymphocytes. The Ki67 score was approximately 20%. CD1a+ cells were densely infiltrated around the hair follicles (fig. [2c](#F2){ref-type="fig"}). Based on the above data, we diagnosed PLF. One month after the skin biopsy, the nodule spontaneously decreased. Six months after the remission of the nodule, there was no sign of local recurrence.

Discussion {#sec1_3}
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PLF is a rare manifestation of cutaneous pseudolymphoma and cutaneous lymphoid hyperplasia. As atypical lymphocytes can be observed in PLF, they must be differentiated from primary malignant cutaneous lymphomas that may present as solitary nodules \[[@B4], [@B5], [@B6], [@B7]\]. However, in contrast to lymphomas, lymphocytes in PLF show no bias in their κ-/γ-chain positive B cell or CD4+/CD8+ T cell ratio \[[@B2], [@B3]\]. Moreover, the distribution of CD1a+ dendritic cells around hair follicles is a typical histological feature of PLF and not a diagnostic feature of cutaneous lymphomas \[[@B2], [@B3]\]. Though these histological findings are indispensable for the diagnosis of PLF, sometimes it takes a long time to achieve the final diagnosis. For the above reasons, another diagnostic tool for the rapid diagnosis for PLF is necessary.

Dermoscopy is a valuable, noninvasive, widely used technique which improved the diagnostic accuracy for skin cancer \[[@B8]\]. It allows in vivo observation of the skin with visualization of morphological structures in the epidermis and papillary dermis, which otherwise would not be discernible to the naked eye. For skin cancers, dermoscopy has had a significant impact on the early diagnosis of solid skin cancers including melanoma, basal cell carcinoma, Bowen\'s disease, actinic keratosis, and squamous cell carcinoma \[[@B8]\]. With regard to lymphoproliferative disorders, recently, Moura et al. \[[@B9]\] reported the dermoscopy findings of lymphomatoid papulosis to define dermoscopic criteria associated with the different stages of the disease. Interestingly, in the present case there were typical dermoscopy features, which suggest the dense infiltrate of CD1a cells around the hair follicles and prominent arborizing vessels. Torres et al. \[[@B10]\] also reported, in conjunction with scalp sarcoidosis, that dermoscopy findings of perifollicular and follicular yellowish spots are connected with dense infiltration of cellular components. Prominent follicular red dots, as previously described by Tosti et al. \[[@B11]\], were similar to those of scalp discoid lupus erythematosus. In summary, the present dermoscopy findings add another diagnostic feature for follicular disorders on the scalp and lymphoproliferative disorders. Though the present findings are limited because they came from a single case only, they might be supportive for the early diagnosis of PLF.

![A red, dome-shaped nodule, 15 × 14 mm in size on the right side of the nose (**a**). Prominent multiple perifollicular and follicular yellowish spots, follicular red dots, and arborizing vessels (**b**).](cde-0004-0154-g01){#F1}

![A dense lymphocytic infiltrate containing numerous histiocytes that surrounded and infiltrated hypertrophic hair follicles. The infiltrate is separated from the epidermis by a grenz zone. There was no reactive pattern to the follicular centers (**a**). Infiltrated cells were medium-sized with a high nuclear/cytoplasmic ratio and prominant nucleoli (**b**). CD1a+ cells were densely infiltrated around the hair follicle (**c**). Original magnification, ×100 (**a**), ×400 (**b**), ×200 (**c**).](cde-0004-0154-g02){#F2}
